[ { "uniprot_canonical_ac": "Q3ZBA8-1", "uniprot_ac": "Q3ZBA8", "uniprot_id": "NDRG2_BOVIN", "mass": { "chemical_mass": 39208.0, "monoisotopic_mass": 39208.0 }, "refseq": { "ac": "NP_001030381", "name": "protein NDRG2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030381" }, "gene_names": [ { "name": "NDRG2", "type": "recommended", "evidence": [ { "id": "Q3ZBA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ] }, { "name": "NDRG2", "type": "synonym", "evidence": [ { "id": "NP_001030381", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030381" } ] } ], "protein_names": [ { "name": "Protein NDRG2", "type": "recommended", "evidence": [ { "id": "Q3ZBA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8/entry#names_and_taxonomy" } ] }, { "name": "N-myc downstream-regulated gene 2 protein", "type": "synonym", "evidence": [ { "id": "NP_001030381", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030381" }, { "id": "Q3ZBA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8/entry#names_and_taxonomy" } ] }, { "name": "protein NDRG2", "type": "synonym", "evidence": [ { "id": "NP_001030381", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030381" } ] } ], "function": [ { "annotation": "Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TD16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD16#function" }, { "database": "UniProtKB", "id": "RU367129", "url": "https://www.uniprot.org/uniprotkb/RU367129#function" }, { "database": "UniProtKB", "id": "ARBA00046250", "url": "https://www.uniprot.org/uniprotkb/ARBA00046250#function" }, { "database": "UniProtKB", "id": "F1MTZ1", "url": "https://www.uniprot.org/uniprotkb/F1MTZ1#function" }, { "database": "UniProtKB", "id": "A0AAA9SGM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM5#function" }, { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NDRG2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8", "locus": { "chromosome": "10", "start_pos": 26087333, "end_pos": 26078548, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000843", "url": "https://www.ensembl.org/id/ENSBTAG00000000843" } ] } } ], "crossref": [ { "id": "Q3ZBA8", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBA8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000843", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000843", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515063", "url": "https://www.ncbi.nlm.nih.gov/gene/515063", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004142", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004142", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515063", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515063", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KTCFQPL", "url": "https://omabrowser.org/oma/group/KTCFQPL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBA8", "url": "https://www.orthodb.org/?gene=Q3ZBA8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11034", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11034", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030381", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SGM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCR1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCR1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCR1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD16-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTZ1", "url": "https://www.uniprot.org/uniprotkb/F1MTZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTZ1-1", "url": "https://www.uniprot.org/uniprotkb/F1MTZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBA8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAELREVQITEEKPLLPGQTPEVAKTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFADMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCILQYLNFSTIIGIGVGAGAYVLSRYALTHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSISEMILGHLFSQEELSGNSELIQKYRNIIAHAPNLDNIELYWNSYNNRRDLNFVRGGDTTLKCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASIDGNRSRSRTLSQSSESGTLSSGPPGHTMEVSC", "length": 357, "header": "sp|Q3ZBA8-1|NDRG2_BOVIN Isoform 1 of Protein NDRG2 OS=Bos taurus OX=9913 GN=NDRG2 PE=2 SV=1 CANONICAL=Q3ZBA8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGM5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8/entry#A0AAA9SGM5-1", "sequence": { "sequence": "MAELREVQITEEKPLLPGQTPEVAKTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFADMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCILQYLNFSTIIGIGVGAGAYVLSRYALTHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSISEMILGHLFSQEELSGNSELIQKYRNIIAHAPNLDNIELYWNSYNNRRDLNFVRGGDTTLKCPVMLVVGDQAPHEDAVMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASIDGNRSRSRTLSQSSESGTLSSGPPGHTMEVSC", "length": 341, "header": "tr|A0AAA9SGM5-1|NDRG2_BOVIN Computationally mapped isoform of Protein NDRG2 OS=Bos taurus OX=9913 GN=NDRG2 PE=2 SV=1 CANONICAL=Q3ZBA8-1" }, "locus": { "chromosome": "10", "start_pos": 26086501, "end_pos": 26081024, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126371.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126371.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083023.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083023.1" } ] } }, { "isoform_ac": "A0AAA9TCR1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8/entry#A0AAA9TCR1-1", "sequence": { "sequence": "MAELREVQITEEKPLLPGQTPEVAKTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFADMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCILQYLNFSTIIGIGVGAGAYVLSRYALTGLTSSISEMILGHLFSQEELSGNSELIQKYRNIIAHAPNLDNIELYWNSYNNRRDLNFVRGGDTTLKCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASIDGNRSRSRTLSQSSESGTLSSGPPGHTMEVSC", "length": 328, "header": "tr|A0AAA9TCR1-1|NDRG2_BOVIN Computationally mapped isoform of Protein NDRG2 OS=Bos taurus OX=9913 GN=NDRG2 PE=2 SV=1 CANONICAL=Q3ZBA8-1" }, "locus": { "chromosome": "10", "start_pos": 26086501, "end_pos": 26081024, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116536.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116536.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096453.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096453.1" } ] } }, { "isoform_ac": "A0AAA9TD16-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8/entry#A0AAA9TD16-1", "sequence": { "sequence": "MAELREVQITEEKPLLPGQTPEVAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFADMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCILQYLNFSTIIGIGVGAGAYVLSRYALTHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSISEMILGHLFSQEELSGNSELIQKYRNIIAHAPNLDNIELYWNSYNNRRDLNFVRGGDTTLKCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASIDGNRSRSRTLSQSSESGTLSSGPPGHTMEVSC", "length": 371, "header": "tr|A0AAA9TD16-1|NDRG2_BOVIN Computationally mapped isoform of Protein NDRG2 OS=Bos taurus OX=9913 GN=NDRG2 PE=2 SV=1 CANONICAL=Q3ZBA8-1" }, "locus": { "chromosome": "10", "start_pos": 26086501, "end_pos": 26081024, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089992.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089992.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094640.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094640.1" } ] } }, { "isoform_ac": "F1MTZ1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8/entry#F1MTZ1-1", "sequence": { "sequence": "MAELREVQITEEKPLLPGQTPEVAKTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFADMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCILQYLNFSTIIGIGVGAGAYVLSRYALTHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSISEMILGHLFSQEELSGNSELIQKYRNIIAHAPNLDNIELYWNSYNNRRDLNFVRGGDTTLKCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKVSNPIPHSPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASIDGNRSRSRTLSQSSESGTLSSGPPGHTMEVSC", "length": 353, "header": "tr|F1MTZ1-1|NDRG2_BOVIN Computationally mapped isoform of Protein NDRG2 OS=Bos taurus OX=9913 GN=NDRG2 PE=2 SV=3 CANONICAL=Q3ZBA8-1" }, "locus": { "chromosome": "10", "start_pos": 26086501, "end_pos": 26081024, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001121.8", "url": "https://www.ensembl.org/id/ENSBTAT00000001121.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001121.6", "url": "https://www.ensembl.org/id/ENSBTAP00000001121.6" } ] } }, { "isoform_ac": "Q3ZBA8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8/entry#Q3ZBA8-1", "sequence": { "sequence": "MAELREVQITEEKPLLPGQTPEVAKTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFADMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCILQYLNFSTIIGIGVGAGAYVLSRYALTHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSISEMILGHLFSQEELSGNSELIQKYRNIIAHAPNLDNIELYWNSYNNRRDLNFVRGGDTTLKCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASIDGNRSRSRTLSQSSESGTLSSGPPGHTMEVSC", "length": 357, "header": "sp|Q3ZBA8-1|NDRG2_BOVIN Isoform 1 of Protein NDRG2 OS=Bos taurus OX=9913 GN=NDRG2 PE=2 SV=1 CANONICAL=Q3ZBA8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 20, "end_pos": 20, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "site_lbl": "Thr20" }, { "start_pos": 312, "end_pos": 312, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "site_lbl": "Ser312" }, { "start_pos": 314, "end_pos": 314, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "site_lbl": "Ser314" }, { "start_pos": 316, "end_pos": 316, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "site_lbl": "Thr316" }, { "start_pos": 318, "end_pos": 318, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "site_lbl": "Ser318" }, { "start_pos": 320, "end_pos": 320, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "site_lbl": "Thr320" }, { "start_pos": 321, "end_pos": 321, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "site_lbl": "Ser321" }, { "start_pos": 324, "end_pos": 324, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "site_lbl": "Ser324" }, { "start_pos": 330, "end_pos": 330, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "site_lbl": "Ser330" }, { "start_pos": 334, "end_pos": 334, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "site_lbl": "Thr334" }, { "start_pos": 336, "end_pos": 336, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "site_lbl": "Ser336" }, { "start_pos": 338, "end_pos": 338, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "site_lbl": "Ser338" }, { "start_pos": 339, "end_pos": 339, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "site_lbl": "Ser339" }, { "start_pos": 341, "end_pos": 341, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "site_lbl": "Ser341" }, { "start_pos": 343, "end_pos": 343, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "site_lbl": "Thr343" }, { "start_pos": 356, "end_pos": 356, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "site_lbl": "Ser356" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515063", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515063", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061IQG8-1", "protein_name": "Protein NDRG2", "gene_name": "Ndrg2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAELQEVQITEEKPLLPGQTPETAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAIFTYHDVGLNYKSCFQPLFQFGDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCILQYLNFSTIIGVGVGAGAYILSRYALTHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLENIELYWNSYNNRRDLNFERGGEMTLKCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASIDGSRSRSRTLSQSSESGTLPSGPPGHTMEVSC", "length": 371 }, "evidence": [ { "id": "Q3ZBA8", "url": "https://omabrowser.org/oma/group/Q3ZBA8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5PR98-1", "protein_name": "Protein NDRG2", "gene_name": "ndrg2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTTEMQEIAITEEKPLLPGQSDAVKDAEIAARILLDQGQEHTVETPHGVLHVTVHGSGNARRPAILTIHDVGMDSKSCFSTLFRFEEMQEIVKNFTVVHIDAPGQEEGAAVYPAGYQYASMDQVSEMLPAVLQFFNFRTIIGVGVGAGAYILSRFTLNNPEAVEGLVLVNVDPNARGWMDWAAHKLSNLTSSLSDQIISHLFSQQELSANTELIQTHRERITKAPNLLNIELFWKSYLGRRDLSLDRNNTFKCPVMLVVGDQAPYEEAAVECNSKLDPTTTSFLKMADAGGMPQLTQPSKLTEAFKYFIQGMGYMASSCMTRLSRSRTTSLSSSYSMEGSRSRSRTLSQGSQGGQLPPSPSNTMEVSC", "length": 368 }, "evidence": [ { "id": "Q3ZBA8", "url": "https://omabrowser.org/oma/group/Q3ZBA8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9QYG0-1", "protein_name": "Protein NDRG2", "gene_name": "Ndrg2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAELQEVQITEEKPLLPGQTPETAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAIFTYHDVGLNYKSCFQPLFRFGDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCILQYLNFSTIIGVGVGAGAYILSRYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPDMILGHLFSQEELSGNSELIQKYRGIIQHAPNLENIELYWNSYNNRRDLNFERGGETTLKCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASIDGSRSRSRTLSQSSESGTLPSGPPGHTMEVSC", "length": 371 }, "evidence": [ { "id": "Q3ZBA8", "url": "https://omabrowser.org/oma/group/Q3ZBA8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UN36-1", "protein_name": "Protein NDRG2", "gene_name": "NDRG2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLRCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASVDGNRSRSRTLSQSSESGTLSSGPPGHTMEVSC", "length": 371 }, "evidence": [ { "id": "Q3ZBA8", "url": "https://omabrowser.org/oma/group/Q3ZBA8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "pmid": "" }, { "name": "growth cone", "id": "GO:0030426", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 328, "end_pos": 330, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBA8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 357, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBA8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBA8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 20, 312, 314, 316, 318, 320, 321, 324, 330, 334, 336, 338, 339, 341, 343, 356 ], "sequon_annotation_sites": [ { "start_pos": 122, "end_pos": 124 }, { "start_pos": 328, "end_pos": 330 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 16 }, { "field": "total_sites", "count": 16 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ60-1", "uniprot_ac": "Q3SZ60", "uniprot_id": "THOC7_BOVIN", "mass": { "chemical_mass": 23743.0, "monoisotopic_mass": 23743.0 }, "refseq": { "ac": "NP_001035604", "name": "THO complex subunit 7 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035604" }, "gene_names": [ { "name": "LOC101907835", "type": "recommended", "evidence": [ { "id": "Q3SZ60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60" } ] }, { "name": "THOC7", "type": "recommended", "evidence": [ { "id": "Q3SZ60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60" } ] }, { "name": "THOC7", "type": "synonym", "evidence": [ { "id": "NP_001035604", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035604" } ] } ], "protein_names": [ { "name": "THO complex subunit 7 homolog", "type": "recommended", "evidence": [ { "id": "Q3SZ60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60/entry#names_and_taxonomy" } ] }, { "name": "THO complex 7 homolog", "type": "synonym", "evidence": [ { "id": "NP_001035604", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035604" } ] }, { "name": "THO complex subunit 7 homolog", "type": "synonym", "evidence": [ { "id": "NP_001035604", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035604" } ] } ], "function": [ { "annotation": "Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Required for efficient export of polyadenylated RNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ60", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60#function" }, { "database": "UniProtKB", "id": "Q6I9Y2", "url": "https://www.uniprot.org/uniprotkb/Q6I9Y2#function" }, { "database": "UniProtKB", "id": "A0AAA9SHK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHK1#function" }, { "database": "UniProtKB", "id": "ARBA00046174", "url": "https://www.uniprot.org/uniprotkb/ARBA00046174#function" }, { "database": "UniProtKB", "id": "A0AAF7AES6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AES6#function" }, { "database": "UniProtKB", "id": "F1MSQ1", "url": "https://www.uniprot.org/uniprotkb/F1MSQ1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ60", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "THOC7", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60", "locus": { "chromosome": "22", "start_pos": 37620599, "end_pos": 37599652, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032872", "url": "https://www.ensembl.org/id/ENSBTAG00000032872" } ] } } ], "crossref": [ { "id": "Q3SZ60", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ60", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032872", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032872", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510250", "url": "https://www.ncbi.nlm.nih.gov/gene/510250", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008501", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008501", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510250", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510250", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WANSKND", "url": "https://omabrowser.org/oma/group/WANSKND/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MSQ1", "url": "https://www.orthodb.org/?gene=F1MSQ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ60", "url": "https://www.orthodb.org/?gene=Q3SZ60", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23405", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23405", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23405:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23405:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05615", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05615", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-159236", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159236", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001035604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035604", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SHK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHK1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AES6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AES6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AES6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AES6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSQ1", "url": "https://www.uniprot.org/uniprotkb/F1MSQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSQ1-1", "url": "https://www.uniprot.org/uniprotkb/F1MSQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ60", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ60-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAVTDDEVIRKRLLIDGDGAGDDRRINLLVKSFIKWCNSGSQEEGYSQYQRMLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKEIECSIAGAHEKIAECKKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKELEALGKELEHLSHIKESVEDKLELRRKQFHVLLSTIHELQQTLENDEKLSEVEEAQEASMETDPKP", "length": 204, "header": "sp|Q3SZ60-1|THOC7_BOVIN Isoform 1 of THO complex subunit 7 homolog OS=Bos taurus OX=9913 GN=THOC7 PE=2 SV=1 CANONICAL=Q3SZ60-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHK1-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60/entry#A0AAA9SHK1-1", "sequence": { "sequence": "MTNEVIRKRLLIDGDGAGDDRRINLLVKSFIKWCNSGSQEEGYSQYQRMLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKEIECSIAGAHEKIAECKKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKELEALGKELEHLSHIKESVEDKLELRRKQFHVLLSTIHELQQTLENDEKLSEVEEAQEASMETDPKP", "length": 200, "header": "tr|A0AAA9SHK1-1|THOC7_BOVIN Computationally mapped isoform of THO complex subunit 7 homolog OS=Bos taurus OX=9913 GN=THOC7 PE=2 SV=1 CANONICAL=Q3SZ60-1" }, "locus": { "chromosome": "22", "start_pos": 37619595, "end_pos": 37601162, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115283.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115283.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085679.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085679.1" } ] } }, { "isoform_ac": "A0AAF7AES6-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60/entry#A0AAF7AES6-1", "sequence": { "sequence": "FGRLSDYEVIRKRLLIDGDGAGDDRRINLLVKSFIKWCNSGSQEEGYSQYQRMLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKEIECSIAGAHEKIAECKKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKELEALGKELEHLSHIKESVEDKLELRRKQFHVLLSTIHELQQTLENDEKLSEVEEAQEASMETDPKP", "length": 204, "header": "tr|A0AAF7AES6-1|THOC7_BOVIN Computationally mapped isoform of THO complex subunit 7 homolog OS=Bos taurus OX=9913 GN=THOC7 PE=2 SV=1 CANONICAL=Q3SZ60-1" }, "locus": { "chromosome": "22", "start_pos": 37619595, "end_pos": 37612940, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070159.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070159.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068025.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068025.2" } ] } }, { "isoform_ac": "F1MSQ1-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60/entry#F1MSQ1-1", "sequence": { "sequence": "MGAVTDDLLKNTDENFQYRKNEEKHLKMTNEVIRKRLLIDGDGAGDDRRINLLVKSFIKWCNSGSQEEGYSQYQRMLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKEIECSIAGAHEKIAECKKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKELEALGKELEHLSHIKESVEDKLELRRKQFHVLLSTIHELQQTLENDEKLSEVEEAQEASMETDPKP", "length": 227, "header": "tr|F1MSQ1-1|THOC7_BOVIN Computationally mapped isoform of THO complex subunit 7 homolog OS=Bos taurus OX=9913 GN=THOC7 PE=2 SV=5 CANONICAL=Q3SZ60-1" }, "locus": { "chromosome": "22", "start_pos": 37619595, "end_pos": 37601162, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046670.6", "url": "https://www.ensembl.org/id/ENSBTAT00000046670.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043944.6", "url": "https://www.ensembl.org/id/ENSBTAP00000043944.6" } ] } }, { "isoform_ac": "Q3SZ60-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60/entry#Q3SZ60-1", "sequence": { "sequence": "MGAVTDDEVIRKRLLIDGDGAGDDRRINLLVKSFIKWCNSGSQEEGYSQYQRMLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKEIECSIAGAHEKIAECKKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKELEALGKELEHLSHIKESVEDKLELRRKQFHVLLSTIHELQQTLENDEKLSEVEEAQEASMETDPKP", "length": 204, "header": "sp|Q3SZ60-1|THOC7_BOVIN Isoform 1 of THO complex subunit 7 homolog OS=Bos taurus OX=9913 GN=THOC7 PE=2 SV=1 CANONICAL=Q3SZ60-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 5, "end_pos": 5, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ60", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60" } ], "site_lbl": "Thr5" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510250", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510250", "resource": "KEGG Pathway" }, { "id": "R-BTA-159236", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159236", "resource": "Reactome", "description": "Transport of Mature mRNA derived from an Intron-Containing Transcript" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VF75-1", "protein_name": "THO complex subunit 7", "gene_name": "THOC7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLYEYEVIRKRLLIDGDGAGDDRRINLLVKSFIKWCNSGSQEEGYSQYQRMLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKEIECSIAGAHEKIAECKKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKELEALGKELEHLSHIKESVEDKLELRRKQFHVLLSTIHELQQTLENDEKLSEVEEAQETSMETDPKP", "length": 203 }, "evidence": [ { "id": "Q3SZ60", "url": "https://omabrowser.org/oma/group/Q3SZ60/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6ABD9-1", "protein_name": "THO complex subunit 7", "gene_name": "Thoc7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQCAEGAAWGASPALLSRAHRQRGGPLGALELGGRWSEDTEVGTASKRNRGVWRAGREVYLGGLQDEVIRKRLLIDGDGAGDDRRINLLVKSFIKWCNSGSQEEGYSQYQRMLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKEIECSIAGAHEKIAECKKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKELEALGKELEHLSHIKESVEDKLELRRKQFHVLLSTIHELQQTLENDDKLSEVEEAQESAMEADPKP", "length": 263 }, "evidence": [ { "id": "Q3SZ60", "url": "https://omabrowser.org/oma/group/Q3SZ60/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1N915-1", "protein_name": "THO complex 7", "gene_name": "THOC7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGAVTDDEVIRKRLLIDGDGAGDDRRINLLVKSFIKWCNSGSQEEGYSQYQRMLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKDIENSIAAAHEKISECKKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKQLEALGKELQHLSHIKENVEDKLELRRKQFHVLLSTIHELQQTLENDEKLSEAEESQETQMEAETKQ", "length": 204 }, "evidence": [ { "id": "Q3SZ60", "url": "https://omabrowser.org/oma/group/Q3SZ60/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HIR7-1", "protein_name": "THO complex subunit 7 homolog isoform X2", "gene_name": "Thoc7", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKEIECSIAGAHEKIAECKKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKELEALGKELEHLSHIKESVEDKLELRRKQFHVLLSTIHELQQTLENDDKLSEVDEAQESAMEADPKP", "length": 152 }, "evidence": [ { "id": "Q3SZ60", "url": "https://omabrowser.org/oma/group/Q3SZ60/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q552L5-1", "protein_name": "THO complex subunit 7 homolog", "gene_name": "thoc7", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKLIKKLLEDEEDSFFKNKIVFKNFVIKKVFKKYLQFINVTTGNNENSSVDLQSLCTQLINEFGHLELSVQKAQTISETCTDETLYYQQLSKQREIEIENEKKEIAILKETLDYEKKQRQYKEQYLALYKAINEKPSTEQTEKEIEKAQKELNEITDQTNKTTSKLELRTKQFQLLLHTLNELEKNLDESIPFIENSNNNNNNSNSDQSNTPMES", "length": 215 }, "evidence": [ { "id": "Q3SZ60", "url": "https://omabrowser.org/oma/group/Q3SZ60/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6DGZ3-1", "protein_name": "THO complex subunit 7 homolog", "gene_name": "thoc7", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGSITDDEVIRKRLLIDGDGAGDDRRINVLMKSFTKWCHSSFSPEEGMSQYQRMMMSLAQCEFSMGKTLLVYNMNLKEMENYEGIYTDIEKSIASAHEKIAECKKEIQRAKRIRKNRQEYDALARVIKQHPDRHETLKQLEALDKDLQQLSHIKENVEDKLELRKKQFHVLLTTIQELQQTLENDEKMESDDTQDSPMENGD", "length": 202 }, "evidence": [ { "id": "Q3SZ60", "url": "https://omabrowser.org/oma/group/Q3SZ60/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6I9Y2-1", "protein_name": "THO complex subunit 7", "gene_name": "THOC7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGAVTDDEVIRKRLLIDGDGAGDDRRINLLVKSFIKWCNSGSQEEGYSQYQRMLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKEIECSIAGAHEKIAECKKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKELEALGKELEHLSHIKESVEDKLELRRKQFHVLLSTIHELQQTLENDEKLSEVEEAQEASMETDPKP", "length": 204 }, "evidence": [ { "id": "Q3SZ60", "url": "https://omabrowser.org/oma/group/Q3SZ60/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7TMY4-1", "protein_name": "THO complex subunit 7 homolog", "gene_name": "Thoc7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGAVTDDEVIRKRLLIDGDGAGDDRRINLLVKSFIKWCNSGSQEEGYSQYQRMLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKEIECSIAGAHEKIAECKKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKELEALGKELEHLSHIKESVEDKLELRRKQFHVLLSTIHELQQTLENDDKLSEVDEAQESTMEADPKP", "length": 204 }, "evidence": [ { "id": "Q3SZ60", "url": "https://omabrowser.org/oma/group/Q3SZ60/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IRJ8-2", "protein_name": "THO complex protein 7", "gene_name": "thoc7", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSEQCQLRPHSDTLVRKLVEMNDEEIIKQRLLIDGDGTGEDRRIVVLLKQFLKWASDSLDSNPIMYDRLMAQFAQCKLTALKNVQTLQMIAGERDNYTQLVEHHEESIVLAKAEIESSKKELITAKQIRKNKMEYDLLASLIQDQPDRSETQRHIETIRREIDDLVQKKLKMERKFQKRRNDFTLLMYTIHELEQQLDQDSSSSASSSSSDCDARSEPDLDDNGIMEVSDEDDDLNNSTPTKFDGARGEPKYHSVSTEDSKAMSVEEDTVLELSIDKDEHDVDVAVAN", "length": 288 }, "evidence": [ { "id": "Q3SZ60", "url": "https://omabrowser.org/oma/group/Q3SZ60/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q8LDS5-1", "protein_name": "THO complex subunit 7A", "gene_name": "THO7A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSVRARRIVSGRSETVAANYAFDPLHDDKIIRNRLLTRTTTTRGEPPLKKLQKKFTSFVIELDKEEDNYSECGRLAKAFLQELSAFEIPLLKSQVVVAANLREKENFNELKDETNRQIMQAQADIEDLKKQLEESKIERQQKEECEAIRKLISAQPPRSETQKVIHELKKEIAELEAENTASWRLLELRKKQFALLLHVVDELQETMEDEQKSMVEEMQRNITADGAEAMSID", "length": 233 }, "evidence": [ { "id": "Q3SZ60", "url": "https://omabrowser.org/oma/group/Q3SZ60/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ60", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ60", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ60", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ60", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60" } ], "pmid": "" }, { "name": "THO complex part of transcription export complex", "id": "GO:0000445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000445", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ60", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ60", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60" } ], "pmid": "" }, { "name": "mRNA export from nucleus", "id": "GO:0006406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006406", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ60", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ60", "url": "https://www.uniprot.org/uniprotkb/Q3SZ60" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ60-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 204, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ60-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ60" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 5 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SYS9-1", "uniprot_ac": "Q3SYS9", "uniprot_id": "KBP_BOVIN", "mass": { "chemical_mass": 72040.0, "monoisotopic_mass": 72040.0 }, "refseq": { "ac": "NP_001029731", "name": "KIF-binding protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029731" }, "gene_names": [ { "name": "KIFBP", "type": "recommended", "evidence": [ { "id": "Q3SYS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9" } ] }, { "name": "KBP", "type": "synonym", "evidence": [ { "id": "NP_001029731", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029731" }, { "id": "Q3SYS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9" } ] }, { "name": "KIF1BP", "type": "synonym", "evidence": [ { "id": "NP_001029731", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029731" } ] }, { "name": "KIFBP", "type": "synonym", "evidence": [ { "id": "NP_001029731", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029731" } ] } ], "protein_names": [ { "name": "KIF-binding protein", "type": "recommended", "evidence": [ { "id": "Q3SYS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9/entry#names_and_taxonomy" } ] }, { "name": "KIF-binding protein", "type": "synonym", "evidence": [ { "id": "NP_001029731", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029731" } ] }, { "name": "KIF1 binding protein", "type": "synonym", "evidence": [ { "id": "NP_001029731", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029731" } ] }, { "name": "KIF1-binding protein", "type": "synonym", "evidence": [ { "id": "Q3SYS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Activator of KIF1B plus-end-directed microtubule motor activity. Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS9", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9#function" }, { "database": "UniProtKB", "id": "Q96EK5", "url": "https://www.uniprot.org/uniprotkb/Q96EK5#function" }, { "database": "UniProtKB", "id": "A0AAA9T812", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T812#function" }, { "database": "UniProtKB", "id": "ARBA00045179", "url": "https://www.uniprot.org/uniprotkb/ARBA00045179#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SYS9", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KIFBP", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9", "locus": { "chromosome": "28", "start_pos": 25302696, "end_pos": 25248020, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014561", "url": "https://www.ensembl.org/id/ENSBTAG00000014561" } ] } } ], "crossref": [ { "id": "Q3SYS9", "url": "https://alphafold.ebi.ac.uk/entry/Q3SYS9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014561", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014561", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "527433", "url": "https://www.ncbi.nlm.nih.gov/gene/527433", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527433", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527433", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ICRECWY", "url": "https://omabrowser.org/oma/group/ICRECWY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SYS9", "url": "https://www.orthodb.org/?gene=Q3SYS9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46321", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46321", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46321:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46321:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12309", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12309", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029731", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SHU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHU9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHU9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T812", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T812", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T812-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T812-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYS9", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYS9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADSPWDEIREKFQTALALSRVELHKNPEKEPYKSKYSARALLEEVKALLGPAPEDEDERPQADDSLGAGEHALGLPAELVEAEGPVAQGAVRRAVIEFHLGVNHIDTEELSAGEEHLVKCLRLLRKYRLSHDCVSLYIQAQNNLGILWSEREEIETAQAYLESSEALYNQYMKEIGSPPLDPTEHFLPEEEKLPEQERSKRFEKVYTHNLYYLAQVYQHMEMFEKAAHYCHSTLKRQLEHNAYHPMEWAINAATLSQFYINKQCFMEARHCLSAANVIFGQIGKIRTTEDTTEAEGDVPELYHQRKGEIARCWIKYCLTLMQNAQLSMQDNIGELDLDKQSELRALRKKELDEEESVRKKAVQFGTGELCDAISAVEEKVSYLRPLDFEEARELFLTGQHYVFEAKEFFQIDGYVTDHIEVVQDHSALFKVLAFFETDMERRCKMHKRRIAMLEPLIVDLNPQYYLLVNRQIQFEIAHAYYDMMDLKVAIADKLRDPDSHIVKKINNLNKSALKYYQLFLDSLRDPNKVFPEHIGEDVLRPAMLAKFRVARLYGKIITADPKKELENLATSLEHYKFIVDYCEKHPEAAQEIEVELELSKEMVSLLPTKMERFRTKMALT", "length": 621, "header": "sp|Q3SYS9-1|KBP_BOVIN Isoform 1 of KIF-binding protein OS=Bos taurus OX=9913 GN=KIFBP PE=2 SV=1 CANONICAL=Q3SYS9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHU9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9/entry#A0AAA9SHU9-1", "sequence": { "sequence": "MADSPWDEIREKFQTALALSRVELHKNPEKEPYKSKYSARALLEEVKALLGPAPEDEDERPQADDSLGAGEHALGLPAELVEAEGPVAQGAVRRAVIEFHLGVNHIDTEELSAGEEHLVKCLRLLRKYRLSHDCVSLYIQAQNNLGILWSEREEIETAQAYLESSEALYNQYMKEIGSPPLDPTEHFLPEEEKLPEQERSKRTT", "length": 204, "header": "tr|A0AAA9SHU9-1|KBP_BOVIN Computationally mapped isoform of KIF-binding protein OS=Bos taurus OX=9913 GN=KIFBP PE=2 SV=1 CANONICAL=Q3SYS9-1" }, "locus": { "chromosome": "28", "start_pos": 25301268, "end_pos": 25248061, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116667.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116667.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084918.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084918.1" } ] } }, { "isoform_ac": "A0AAA9T812-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9/entry#A0AAA9T812-1", "sequence": { "sequence": "MADSPWDEIREKFQTALALSRVELHKNPEKEPYKSKYSARALLEEVKALLGPAPEDEDERPQADDSLGAGEHALGLPAELVEAEGPVAQGAVRRAVIEFHLGVNHIDTEELSAGEEHLVKCLRLLRKYRLSHDCVSLYIQAQNNLGILWSEREEIETAQAYLESSEALYNQYMKEIGSPPLDPTEHFLPEEEKLPEQERSKRFEKVYTHNLYYLAQVYQHMEMFEKAAHYCHSTLKRQLEHNAYHPMEWAINAATLSQFYINKQCFMEARHCLSAANVIFGQIGKIRTTEDRQHRRA", "length": 297, "header": "tr|A0AAA9T812-1|KBP_BOVIN Computationally mapped isoform of KIF-binding protein OS=Bos taurus OX=9913 GN=KIFBP PE=2 SV=1 CANONICAL=Q3SYS9-1" }, "locus": { "chromosome": "28", "start_pos": 25301278, "end_pos": 25248061, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104487.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104487.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094879.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094879.1" } ] } }, { "isoform_ac": "Q3SYS9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9/entry#Q3SYS9-1", "sequence": { "sequence": "MADSPWDEIREKFQTALALSRVELHKNPEKEPYKSKYSARALLEEVKALLGPAPEDEDERPQADDSLGAGEHALGLPAELVEAEGPVAQGAVRRAVIEFHLGVNHIDTEELSAGEEHLVKCLRLLRKYRLSHDCVSLYIQAQNNLGILWSEREEIETAQAYLESSEALYNQYMKEIGSPPLDPTEHFLPEEEKLPEQERSKRFEKVYTHNLYYLAQVYQHMEMFEKAAHYCHSTLKRQLEHNAYHPMEWAINAATLSQFYINKQCFMEARHCLSAANVIFGQIGKIRTTEDTTEAEGDVPELYHQRKGEIARCWIKYCLTLMQNAQLSMQDNIGELDLDKQSELRALRKKELDEEESVRKKAVQFGTGELCDAISAVEEKVSYLRPLDFEEARELFLTGQHYVFEAKEFFQIDGYVTDHIEVVQDHSALFKVLAFFETDMERRCKMHKRRIAMLEPLIVDLNPQYYLLVNRQIQFEIAHAYYDMMDLKVAIADKLRDPDSHIVKKINNLNKSALKYYQLFLDSLRDPNKVFPEHIGEDVLRPAMLAKFRVARLYGKIITADPKKELENLATSLEHYKFIVDYCEKHPEAAQEIEVELELSKEMVSLLPTKMERFRTKMALT", "length": 621, "header": "sp|Q3SYS9-1|KBP_BOVIN Isoform 1 of KIF-binding protein OS=Bos taurus OX=9913 GN=KIFBP PE=2 SV=1 CANONICAL=Q3SYS9-1" }, "locus": { "chromosome": "28", "start_pos": 25302134, "end_pos": 25248061, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019353.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019353.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019353.2", "url": "https://www.ensembl.org/id/ENSBTAP00000019353.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 178, "end_pos": 178, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS9", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9" } ], "site_lbl": "Ser178" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:527433", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527433", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1TLJ5-1", "protein_name": "KIF-binding protein", "gene_name": "KIFBP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MADAPWVELREKFQAALALSRVELHKNPEKEPYKSKYHARALLEEVKALLGPAPEDEDDRPQAEDSLGTGDHTLGLPAELVEAEGPIALGAVRRAVIEFHLGVNHIDTEELSAGEEHLVKCLRLLRKYRMSQDCVSLYIQAQNNLGILWSEREEIESAQAYLESSEALYNQYMKEIGSPPLDPTEHFLSEEEKLAEQERSKRFEKVYTHNLYYLAQVYQHMEMFEKAAHYCHSTLKRQLEHNAYHPMEWAINAATLSQFYINKQCFMEARHCLSAANVIFGQTGKISTMEDTTEAEGDVPELYHQRKGEIARCWIKYCLTLMQNAQLSMQDNIGELDLDKQSELRALRKKELDEEESVRKKAVQFGTGELCDAISAVEEKVSYLRPLDFEEARELFLTGQHYVFEAKEFFQIDGYVTDHIEVVQDHSALFKVLAFFETDMERRCKMHKRRIAMLEPLIVDLNPQYYLLVNRQIQFEIAHAYYDMMDLKVAIADKLRDPDSHIVKKINNLNKSALKYYQLFLDSLRDPNKVFPEHIGEDVLRPAMLAKFRVARLYGKIITADPKKELENLATSLEHYKFIVDYCERHPEAAQEIEVELELSKEMVSLLPTKMERFRTKMALT", "length": 621 }, "evidence": [ { "id": "Q3SYS9", "url": "https://omabrowser.org/oma/group/Q3SYS9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q4G074-1", "protein_name": "KIF-binding protein", "gene_name": "Kifbp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGAPGPEIREKFQAALALSRVELHKNPEKEPYKSKYGARALLEEVRALLGPAPEDDDERAADDGPVDQALGAGEPRDAEGPGAQRALRLAVVEFHLGVNHIDTEELSAGEEHLVRCLSLLRPYRLSLGCVSLFIQAQNNLGILWSEREEIETARTYLESSEALYNQYMKEIGSPPLDPTEHFLPEEEKLTEQERSKRFEKVYTHNLYYLAQVYQHMEMFEKAAHYCHSTLKRQLEHNAYHPMEWAINAATLSQFYINKLCFMEARHCLSAANVIFGQTGKITATEDTPEVEGDMPELYHQRKGEIARCWIKYCLTLMQNAQLSMQDNIGELDLDKQSELRALRRKELDEEESVRKRAVQFGTGELRDAISAVEEKVRYLRPLDFEEARELFLLGQHYVYEAKEFFQIDGYVTDHIEVVQDHSALFKVLAFFEADMERRCKMHKRRIAMLEPLIVDLNPQYYQLVNRQIQFEIAHAYYDMMDLKVAIADKLREPDSHTVKKINSLNQSALKYYQLFLDSLRDPNKVFPEHIGEDVLRPAMLAKFRVARLYGKIITADPKKELENLATSLEHYKFIVDYCETHPEAAQEIEVELELSKEMVSLLPTKMERFRAKMALT", "length": 617 }, "evidence": [ { "id": "Q3SYS9", "url": "https://omabrowser.org/oma/group/Q3SYS9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5ZIL9-1", "protein_name": "KIF-binding protein", "gene_name": "Kifbp", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAAGGGWAAACEKFRSARTLSAVESRKDPETEPYRSKYSARALLQEVKQQLSAAEDCGEARLLAVRRAVLEYELGVNHTDTEELSAGEEHLQRCTQLLEPHRLSRDCVSLYIQAQNNLGILWSERDEIKTAQTYLESAEALYNQYMKEDGNPPLDPSEHFMAEEEKLTDQERSKRFEKAYTHTLYYLAQVYQHLEMIEKAAQYCHTTLKRQLEYCGYYPVEWALNAATLSQYYLSKQCFMESRHCLAAASVIFSQAGQVPSTEDNETEQDQQDLRQRKAEIARCWIKYCLNLLQSARKLLEDNIGELDPDRQLELKAQRKKEEDEKENGRKKAVLFGTSDICDSVLAMEEKVSSVYPLDFQEAREIFLVGQNYVQEAKEFFQVDGYVTDHIEIVQDHSALFKVLAFFEEDYERRCKMHKRRIDMLEPIYADLNPQYYLLISRQLQFELADTYYEMMDLKVAIGNRLEELDSHTIKKINSLAQLAIKYYELFLDSLRNPDKVFPEELEEDVLRPAMVAKFHIARLYGKLITSDSKKQLENMQTSLEYYTFLVDYCEKHPDAVRAVETELELSKEMVGLLPTRMERLRAKLCPFI", "length": 594 }, "evidence": [ { "id": "Q3SYS9", "url": "https://omabrowser.org/oma/group/Q3SYS9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6ZPU9-1", "protein_name": "KIF-binding protein", "gene_name": "Kifbp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MANAPGPEIREKFQAALALSRVELHKNPEKEPYKSKYGARALLEEVRALLGPAPEDEDEPAADDGPGDQALGAGEPREAEGPGAQRALRLAVVEFHLGVNHIDTEELSAGEEHLVRCLSLLRPYRLSLGCVSLYIQAQNNLGILWSEREEIETARTYLESSEALYSQYMKEIGSPPLDPTEHFLPEEEKLTEQERSKRFEKVYTHNLYYLAQVYQHMEMFEKAAHYCHSTLKRQLEHNAYHPMEWAINAATLSQFYINKLCFMEARHCLSAANVIFGQTGKIPATEDTPEVEGDVPELYHQRKGEIARCWIKYCLTLMQNAQLSMQDNIGELDLDKQSELRALRKKELDEEESVRKRAVQFGTGELCDAISAVEEKVRYLRPLDFEEARELFLLGQHYVCEAKEFFQIDGYVTDHIEVVQDHSALFKVLSFFEADMERRCKMHKRRIAMLEPLTVDLNPQYYLLVSRQIQFEIAHAYYDMMDLKVAIADKLRDPDSHIVKKINSLNKSALKYYQLFLDSLRDPNKVFPEHIGEDVLRPAMLAKFRVARLYGKIITADPKKELENLATSLEHYKFIVDYCETHPEAAQEIEVELELSKEMVSLLPTKMERFRAKMALT", "length": 617 }, "evidence": [ { "id": "Q3SYS9", "url": "https://omabrowser.org/oma/group/Q3SYS9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96EK5-1", "protein_name": "KIF-binding protein", "gene_name": "KIFBP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MANVPWAEVCEKFQAALALSRVELHKNPEKEPYKSKYSARALLEEVKALLGPAPEDEDERPEAEDGPGAGDHALGLPAEVVEPEGPVAQRAVRLAVIEFHLGVNHIDTEELSAGEEHLVKCLRLLRRYRLSHDCISLCIQAQNNLGILWSEREEIETAQAYLESSEALYNQYMKEVGSPPLDPTERFLPEEEKLTEQERSKRFEKVYTHNLYYLAQVYQHLEMFEKAAHYCHSTLKRQLEHNAYHPIEWAINAATLSQFYINKLCFMEARHCLSAANVIFGQTGKISATEDTPEAEGEVPELYHQRKGEIARCWIKYCLTLMQNAQLSMQDNIGELDLDKQSELRALRKKELDEEESIRKKAVQFGTGELCDAISAVEEKVSYLRPLDFEEARELFLLGQHYVFEAKEFFQIDGYVTDHIEVVQDHSALFKVLAFFETDMERRCKMHKRRIAMLEPLTVDLNPQYYLLVNRQIQFEIAHAYYDMMDLKVAIADRLRDPDSHIVKKINNLNKSALKYYQLFLDSLRDPNKVFPEHIGEDVLRPAMLAKFRVARLYGKIITADPKKELENLATSLEHYKFIVDYCEKHPEAAQEIEVELELSKEMVSLLPTKMERFRTKMALT", "length": 621 }, "evidence": [ { "id": "Q3SYS9", "url": "https://omabrowser.org/oma/group/Q3SYS9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VMX1-1", "protein_name": "KIF-binding protein", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVIPKEILSDFKELYEKANRLVEEESRNDPPTDPFRSHYKARDVLIVLKKQLDDQLVSVQASEEDGGQDDRCYHSLLAFVCRDLGRIYIYTEEQAEGEKMLNRCLELVTPFKECPEGIIPFIGAINELSIVLASKEEYNKGLEILLEAEKIYEDFKASGLKPLAIQDVFNPPEEGQQSHEAGPKELESLYTLVSFYMAQMYGHLGEPEKSAKCCHRTLHRQLESKTYDPIDFALNTATLSQFYIGEKRFEEARHHLAAATLIMAEYEVHMLEPEMSEKQRQDVSETFKHRYADVARCWAKYGLYLMNTSKLRLMRDEDDEDAKNLEIVLRNMRLVEAEQSRFPGLDLTACENRISCEYCLTFDDAKLVFHFVNEWLDIAKDYYKAENEATEYSKIMQDYAEAYEHIAFFEENPENQAKMQKRRAKYLEDLLDLLDPIFYMKICRECWYGAGTAHAAVMDVRLDIIRATSTPAPEDIKKVNQSCMKAIKHFESYVKSYLVKPPSEEWRPNMDVEEQRHMLYAHFHIGRIYYKLISGHPLQQLEHLTSCHTYYQRFDAGCQLHKEAAETLQGEIGVVREMLQLLPLKINTIKARLNKAGLTA", "length": 600 }, "evidence": [ { "id": "Q3SYS9", "url": "https://omabrowser.org/oma/group/Q3SYS9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "mitochondrion transport along microtubule", "id": "GO:0047497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047497", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS9", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9" } ], "pmid": "" }, { "name": "neuron projection maintenance", "id": "GO:1990535", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990535", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS9", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9" } ], "pmid": "" }, { "name": "central nervous system projection neuron axonogenesis", "id": "GO:0021952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021952", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS9", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9" } ], "pmid": "" }, { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS9", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS9", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS9", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "kinesin binding", "id": "GO:0019894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019894", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS9", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9" } ], "pmid": "" }, { "name": "protein sequestering activity", "id": "GO:0140311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140311", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS9", "url": "https://www.uniprot.org/uniprotkb/Q3SYS9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 510, "end_pos": 512, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SYS9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 621, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SYS9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SYS9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 178 ], "sequon_annotation_sites": [ { "start_pos": 510, "end_pos": 512 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3B7M5-1", "uniprot_ac": "Q3B7M5", "uniprot_id": "LASP1_BOVIN", "mass": { "chemical_mass": 29677.0, "monoisotopic_mass": 29677.0 }, "refseq": { "ac": "NP_001030471", "name": "LIM and SH3 domain protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030471" }, "gene_names": [ { "name": "LASP1", "type": "recommended", "evidence": [ { "id": "Q3B7M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7M5" } ] }, { "name": "LASP1", "type": "synonym", "evidence": [ { "id": "NP_001030471", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030471" } ] } ], "protein_names": [ { "name": "LIM and SH3 domain protein 1", "type": "recommended", "evidence": [ { "id": "Q3B7M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7M5/entry#names_and_taxonomy" } ] }, { "name": "LASP-1", "type": "synonym", "evidence": [ { "id": "NP_001030471", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030471" }, { "id": "Q3B7M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7M5/entry#names_and_taxonomy" } ] }, { "name": "LIM and SH3 domain protein 1", "type": "synonym", "evidence": [ { "id": "NP_001030471", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030471" } ] } ], "function": [ { "annotation": "Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. 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"https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051759", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051759", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532851", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532851", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TPVYHHQ", "url": "https://omabrowser.org/oma/group/TPVYHHQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3B7M5", "url": "https://www.orthodb.org/?gene=Q3B7M5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46218", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46218", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46218:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46218:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00880", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00880", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14604", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14604", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030471", "url": 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domain protein 1 OS=Bos taurus OX=9913 GN=LASP1 PE=2 SV=1 CANONICAL=Q3B7M5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SII4-1", "url": "https://www.uniprot.org/uniprotkb/Q3B7M5/entry#A0AAA9SII4-1", "sequence": { "sequence": "MLPLRDLQDDPQHEELQGLREEALLQRVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGLECERRDPQESSYRRPQEQQQPHHIPASTPVYQQPQQQPAAQSYGGYKEPAAPASIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYGTVERTGDTGMLPANYVEAI", "length": 204, "header": "tr|A0AAA9SII4-1|LASP1_BOVIN Computationally mapped isoform of LIM and SH3 domain protein 1 OS=Bos taurus OX=9913 GN=LASP1 PE=2 SV=1 CANONICAL=Q3B7M5-1" }, "locus": { "chromosome": "19", "start_pos": 39492085, "end_pos": 39461680, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088217.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088217.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082358.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082358.1" } ] } }, { "isoform_ac": "Q3B7M5-1", "url": "https://www.uniprot.org/uniprotkb/Q3B7M5/entry#Q3B7M5-1", "sequence": { "sequence": "MNPNCARCCKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGLECERRDPQESSYRRPQEQQQPHHIPASTPVYQQPQQQPAAQSYGGYKEPAAPASIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYGTVERTGDTGMLPANYVEAI", "length": 260, "header": "sp|Q3B7M5-1|LASP1_BOVIN Isoform 1 of LIM and SH3 domain protein 1 OS=Bos taurus OX=9913 GN=LASP1 PE=2 SV=1 CANONICAL=Q3B7M5-1" }, "locus": { "chromosome": "19", "start_pos": 39492085, "end_pos": 39454757, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043205.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043205.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040793.2", "url": "https://www.ensembl.org/id/ENSBTAP00000040793.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 104, "end_pos": 104, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M5", "url": "https://www.uniprot.org/uniprotkb/Q3B7M5" } ], "site_lbl": "Thr104" }, { "start_pos": 118, "end_pos": 118, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M5", "url": "https://www.uniprot.org/uniprotkb/Q3B7M5" } ], "site_lbl": "Ser118" }, { "start_pos": 134, "end_pos": 134, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M5", "url": "https://www.uniprot.org/uniprotkb/Q3B7M5" } ], "site_lbl": "Ser134" }, { "start_pos": 68, "end_pos": 68, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M5", "url": "https://www.uniprot.org/uniprotkb/Q3B7M5" } ], "site_lbl": "Thr68" }, { "start_pos": 99, "end_pos": 99, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M5", "url": "https://www.uniprot.org/uniprotkb/Q3B7M5" } ], "site_lbl": "Ser99" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:532851", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532851", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q14847-1", "protein_name": "LIM and SH3 domain protein 1", "gene_name": "LASP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYGTVERTGDTGMLPANYVEAI", "length": 261 }, "evidence": [ { "id": "Q3B7M5", "url": "https://omabrowser.org/oma/group/Q3B7M5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M5", "url": "https://www.uniprot.org/uniprotkb/Q3B7M5" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M5", "url": "https://www.uniprot.org/uniprotkb/Q3B7M5" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M5", "url": "https://www.uniprot.org/uniprotkb/Q3B7M5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M5", "url": "https://www.uniprot.org/uniprotkb/Q3B7M5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "monoatomic ion transport", "id": "GO:0006811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006811", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M5", "url": "https://www.uniprot.org/uniprotkb/Q3B7M5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M5", "url": "https://www.uniprot.org/uniprotkb/Q3B7M5" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M5", "url": "https://www.uniprot.org/uniprotkb/Q3B7M5" } ], "pmid": "" }, { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M5", "url": "https://www.uniprot.org/uniprotkb/Q3B7M5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3B7M5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 260, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3B7M5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3B7M5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3B7M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7M5" }, { "id": "PRU00125", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00125" } ], 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SX11-1", "uniprot_ac": "Q3SX11", "uniprot_id": "NSA2_BOVIN", "mass": { "chemical_mass": 30035.0, "monoisotopic_mass": 30035.0 }, "refseq": { "ac": "NP_001029718", "name": "ribosome biogenesis protein NSA2 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029718" }, "gene_names": [ { "name": "NSA2", "type": "recommended", "evidence": [ { "id": "Q3SX11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX11" } ] }, { "name": "NSA2", "type": "synonym", "evidence": [ { "id": "NP_001029718", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029718" } ] }, { "name": "TINP1", "type": "synonym", "evidence": [ { "id": "NP_001029718", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029718" }, { "id": "Q3SX11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX11" } ] } ], "protein_names": [ { "name": "Ribosome biogenesis protein NSA2 homolog", "type": "recommended", "evidence": [ { "id": "Q3SX11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX11/entry#names_and_taxonomy" } ] }, { "name": "TGF beta-inducible nuclear protein 1 (L-name related LNR42)", "type": "synonym", "evidence": [ { "id": "NP_001029718", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029718" } ] }, { "name": "TGF-beta-inducible nuclear protein 1", "type": "synonym", "evidence": [ { "id": "NP_001029718", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029718" }, { "id": "Q3SX11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX11/entry#names_and_taxonomy" } ] }, { "name": "ribosome biogenesis protein NSA2 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029718", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029718" } ] } ], "function": [ { "annotation": "Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJM0#function" }, { "database": "UniProtKB", "id": "RU367114", "url": "https://www.uniprot.org/uniprotkb/RU367114#function" }, { "database": "UniProtKB", "id": "Q3SX11", "url": "https://www.uniprot.org/uniprotkb/Q3SX11#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SX11", "url": "https://www.uniprot.org/uniprotkb/Q3SX11" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NSA2", "url": "https://www.uniprot.org/uniprotkb/Q3SX11", "locus": { "chromosome": "20", "start_pos": 6742915, "end_pos": 6751738, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003066", "url": "https://www.ensembl.org/id/ENSBTAG00000003066" } ] } } ], "crossref": [ { "id": "Q3SX11", "url": "https://alphafold.ebi.ac.uk/entry/Q3SX11", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003066", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003066", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11381", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11381", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "522309", "url": "https://www.ncbi.nlm.nih.gov/gene/522309", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR022309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039411", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039411", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522309", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522309", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TNTPEND", "url": "https://omabrowser.org/oma/group/TNTPEND/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SX11", "url": "https://www.orthodb.org/?gene=Q3SX11", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12642", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12642", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01201", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01201", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029718", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SJM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJM0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SX11", "url": "https://www.uniprot.org/uniprotkb/Q3SX11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SX11-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX11-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPQNEYIELHRKRYGYRLDYHEKKRKKEGREAHERSKKAKKMIGLKAKLYHKQRHAEKIQMKKTIKMHEKRNTKQKNDEKTPQGAVPAYLLDREGQSRAKVLSNMIKQKRKEKAGKWEVPLPKVRAQGETEVLKVIRTGKRKKKAWKRMVTKVCFVGDGFTRKPPKYERFIRPMGLRFKKAHVTHPELKATFCLPILGVKKNPSSPLYTTLGVITKGTVIEVNVSELGLVTQGGKVIWGKYAQVTNNPENDGCINAVLLV", "length": 260, "header": "sp|Q3SX11-1|NSA2_BOVIN Isoform 1 of Ribosome biogenesis protein NSA2 homolog OS=Bos taurus OX=9913 GN=NSA2 PE=2 SV=1 CANONICAL=Q3SX11-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJM0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX11/entry#A0AAA9SJM0-1", "sequence": { "sequence": "MGILQPQNEYIELHRKRYGYRLDYHEKKRKKEGREAHERSKKAKKMIGLKAKLYHKQRHAEKIQMKKTIKMHEKRNTKQKNDEKTPQGAVPAYLLDREGQSRAKVLSNMIKQKRKEKAGKWEVPLPKVRAQGETEVLKVIRTGKRKKKAWKRMVTKVCFVGDGFTRKPPKYERFIRPMGLRFKKAHVTHPELKATFCLPILGVKKNPSSPLYTTLGVITKGTVIEVNVSELGLVTQGGKVIWGKYAQVTNNPENDGCINAVLLV", "length": 264, "header": "tr|A0AAA9SJM0-1|NSA2_BOVIN Computationally mapped isoform of Ribosome biogenesis protein NSA2 homolog OS=Bos taurus OX=9913 GN=NSA2 PE=2 SV=1 CANONICAL=Q3SX11-1" }, "locus": { "chromosome": "20", "start_pos": 6751539, "end_pos": 6743098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101815.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101815.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086486.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086486.1" } ] } }, { "isoform_ac": "A0AAA9TCM3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX11/entry#A0AAA9TCM3-1", "sequence": { "sequence": "MPQNEYIELHRKRYGYRLDYHEKKRKKEGREAHERSKKAKKMIGLKAKLYHKQRHAEKIQMKKTIKMHEKRNTKQKNDEKTPQGAVPAYLLDREGQSRAKVLSNMIKQKRKEKAGKWEVPLPKVRAQGETEVLKVIRTGKRKKKAWKRMVTKVCFVGDGFTRKPPKYERFIRPMENMPRLPIILKMMDA", "length": 189, "header": "tr|A0AAA9TCM3-1|NSA2_BOVIN Computationally mapped isoform of Ribosome biogenesis protein NSA2 homolog OS=Bos taurus OX=9913 GN=NSA2 PE=2 SV=1 CANONICAL=Q3SX11-1" }, "locus": { "chromosome": "20", "start_pos": 6749934, "end_pos": 6743118, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130417.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130417.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095803.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095803.1" } ] } }, { "isoform_ac": "Q3SX11-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX11/entry#Q3SX11-1", "sequence": { "sequence": "MPQNEYIELHRKRYGYRLDYHEKKRKKEGREAHERSKKAKKMIGLKAKLYHKQRHAEKIQMKKTIKMHEKRNTKQKNDEKTPQGAVPAYLLDREGQSRAKVLSNMIKQKRKEKAGKWEVPLPKVRAQGETEVLKVIRTGKRKKKAWKRMVTKVCFVGDGFTRKPPKYERFIRPMGLRFKKAHVTHPELKATFCLPILGVKKNPSSPLYTTLGVITKGTVIEVNVSELGLVTQGGKVIWGKYAQVTNNPENDGCINAVLLV", "length": 260, "header": "sp|Q3SX11-1|NSA2_BOVIN Isoform 1 of Ribosome biogenesis protein NSA2 homolog OS=Bos taurus OX=9913 GN=NSA2 PE=2 SV=1 CANONICAL=Q3SX11-1" }, "locus": { "chromosome": "20", "start_pos": 6749934, "end_pos": 6743098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003989.3", "url": "https://www.ensembl.org/id/ENSBTAT00000003989.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003989.2", "url": "https://www.ensembl.org/id/ENSBTAP00000003989.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 81, "end_pos": 81, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3SX11", "url": "https://www.uniprot.org/uniprotkb/Q3SX11" } ], "site_lbl": "Thr81" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:522309", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522309", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7I5Q8-1", "protein_name": "Ribosome biogenesis protein NSA2 homolog", "gene_name": "Nsa2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPQNEYIELHRKRYGYRLDYHEKKRKKESREAHERSKKAKKMIGLKAKLYHKQRHAEKIQMKKTIKMHEKRNTKQKNDDKTPQGAVPAYLLDREGQSRAKVLSNMIKQKRKEKAGKWEVPLPKVRAQGETEVLKVIRTGKRKKKAWKRMVTKVCFVGDGFTRKPPKYERFIRPMGLRFKKAHVTHPELKATFCLPILGVKKNPSSPLYTTLGVITKGTVIEVNVSELGLVTQGGKVIWGKYAQVTNNPENDGCINAVLLV", "length": 260 }, "evidence": [ { "id": "Q3SX11", "url": "https://omabrowser.org/oma/group/Q3SX11/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A4X1SRK5-1", "protein_name": "Ribosome biogenesis protein NSA2 homolog", "gene_name": "NSA2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPQNEYIELHRKRYGYRLDYHEKKRKKEGREAHERSKKAKKMIGLKAKLYHKQRHAEKIQMKKTIKMHEKRNTKQKNDEKTPQGAVPAYLLDREGQSRAKVLSNMIKQKRKEKAGKWEVPLPKVRAQGETEVLKVIRTGKRKKKAWKRMVTKVCFVGDGFTRKPPKYERFIRPMGLRFKKAHVTHPELKATFCLPILGVKKNPSSPLYTTLGVITKGTVIEVNVSELGLVTQGGKVIWGKYAQVTNNPENDGCINAVLLV", "length": 260 }, "evidence": [ { "id": "Q3SX11", "url": "https://omabrowser.org/oma/group/Q3SX11/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1QDL2-1", "protein_name": "Ribosome biogenesis protein NSA2 homolog", "gene_name": "nsa2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPQNEHIELHRKRHGYRLDHHEKKRKKESREAHERSHKARKMIGLKAKLYHKQRHAEKIQMKKTIKMHEQRKSKQKDDDKTPEGAVPAYLLDREGQSRAKVLSNMIKQKRKEKAGKWEVPLPKVRAQGETEVLKVIRTGKRQKKAWKRMVTKVCFVGDGFTRKPPKYERFIRPMGLRFNKAHVTHPELKATFCLPILGVKKNPSSSLYTTLGVITKGTVIEVNVSELGLVTQGGKVIWGKYAQVTNNPENDGCINAVLLV", "length": 260 }, "evidence": [ { "id": "Q3SX11", "url": "https://omabrowser.org/oma/group/Q3SX11/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O76994-1", "protein_name": "Ribosome biogenesis protein NSA2 homolog", "gene_name": "Ip259", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPQNEYMERHRKLYGRRLDYEERKRKKEARLPKDRARKARKLRGIKAKLFNKERRNEKIQIKKKIQAHEEKKVKKQEEKVEDGALPHYLLDRGIQSSAKVLSNMIKQKRKEKAGKWDVPIPKVRAQSDAEVFKVLKTGKTKRKAWKRMVTKVTFVGENFTRKPPKFERFIRPMGLRMKKAHVTHPELKATFNLPIIGVKKNPSSPMFTSLGVITKGTVIEVNISELGLVTQTGKVVWGKYAQVTNNPENDGVINAVLLV", "length": 259 }, "evidence": [ { "id": "Q3SX11", "url": "https://omabrowser.org/oma/group/Q3SX11/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "O95478-1", "protein_name": "Ribosome biogenesis protein NSA2 homolog", "gene_name": "NSA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPQNEYIELHRKRYGYRLDYHEKKRKKESREAHERSKKAKKMIGLKAKLYHKQRHAEKIQMKKTIKMHEKRNTKQKNDEKTPQGAVPAYLLDREGQSRAKVLSNMIKQKRKEKAGKWEVPLPKVRAQGETEVLKVIRTGKRKKKAWKRMVTKVCFVGDGFTRKPPKYERFIRPMGLRFKKAHVTHPELKATFCLPILGVKKNPSSPLYTTLGVITKGTVIEVNVSELGLVTQGGKVIWGKYAQVTNNPENDGCINAVLLV", "length": 260 }, "evidence": [ { "id": "Q3SX11", "url": "https://omabrowser.org/oma/group/Q3SX11/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P40078-1", "protein_name": "Ribosome biogenesis protein NSA2", "gene_name": "NSA2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MPQNDYIERHIKQHGKRLDHEERKRKREARESHKISERAQKLTGWKGKQFAKKRYAEKVSMRKKIKAHEQSKVKGSSKPLDTDGDALPTYLLDREQNNTAKAISSSIKQKRLEKADKFSVPLPKVRGISEEEMFKVIKTGKSRSKSWKRMITKHTFVGEGFTRRPVKMERIIRPSALRQKKANVTHPELGVTVFLPILAVKKNPQSPMYTQLGVLTKGTIIEVNVSELGMVTAGGKVVWGKYAQVTNEPDRDGCVNAVLLV", "length": 261 }, "evidence": [ { "id": "Q3SX11", "url": "https://omabrowser.org/oma/group/Q3SX11/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54GN8-1", "protein_name": "Ribosome biogenesis protein NSA2 homolog", "gene_name": "nsa2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MPQGDHIELHQKRFGRRLDHYEKVRKKTARAAHKRSAIAQKVTGLKAKLYNKKRYSEKAEMKKTIAMHQERTNKKASDDKVKEGAVPAYLLDREGVSRAKVLSNMVKQKRKEKAGKWDVPLPKVRAISEDEMFKVVKSGKRQKKAWKRFVTKVTFVGEGFTRKPPKYERFIRPTGLRFKKAHVTHPELKSTFYLDILSVKKNPQSPTYTQLGVITKGTILEVNVSDLGLVTQTGKVVWGKMAQVTNNPENDGCINAVLLV", "length": 260 }, "evidence": [ { "id": "Q3SX11", "url": "https://omabrowser.org/oma/group/Q3SX11/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9CR47-1", "protein_name": "Ribosome biogenesis protein NSA2 homolog", "gene_name": "Nsa2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPQNEYIELHRKRYGYRLDYHEKKRKKEGREAHERSKKAKKMIGLKAKLYHKQRHAEKIQMKKTIKMHEKRNTKQKDDEKTPQGAVPAYLLDREGQSRAKVLSNMIKQKRKEKAGKWEVPLPKVRAQGETEVLKVIRTGKRKKKAWKRMVTKVCFVGDGFTRKPPKYERFIRPMGLRFKKAHVTHPELKATFCLPILGVKKNPSSPLYTTLGVITKGTVIEVNVSELGLVTQGGKVIWGKYAQVTNNPENDGCINAVLLV", "length": 260 }, "evidence": [ { "id": "Q3SX11", "url": "https://omabrowser.org/oma/group/Q3SX11/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9FNH2-1", "protein_name": "Ribosome biogenesis protein NSA2 homolog", "gene_name": "MHF15.12", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MPQGDYIDLHRKRNGYRLDHFERKRKKEAREVHKHSTMAQKSLGIKGKMIAKKNYAEKALMKKTLKMHEESSSRRKADENVQEGAVPAYLLDREDTTRAKVLSNTIKQKRKEKAGKWEVPLPKVRPVAEDEMFRVIRSGKRKTKQWKRMVTKATFVGPAFTRKPPKYERFIRPSGLRFTKAHVTHPELKCTFCLEIIGIKKNPNGPMYTSLGVMTRGTIIEVNVSELGLVTPAGKVVWGKYAQVTNNPENDGCINAVLLV", "length": 260 }, "evidence": [ { "id": "Q3SX11", "url": "https://omabrowser.org/oma/group/Q3SX11/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q3SX11", "url": "https://www.uniprot.org/uniprotkb/Q3SX11" } ], "pmid": "" }, { "name": "preribosome, large subunit precursor", "id": "GO:0030687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030687", "evidence": [ { "database": "UniProtKB", "id": "Q3SX11", "url": "https://www.uniprot.org/uniprotkb/Q3SX11" } ], "pmid": "" }, { "name": "preribosome", "id": "GO:0030684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030684", "evidence": [ { "database": "UniProtKB", "id": "Q3SX11", "url": "https://www.uniprot.org/uniprotkb/Q3SX11" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "maturation of 5.8S rRNA", "id": "GO:0000460", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000460", "evidence": [ { "database": "UniProtKB", "id": "Q3SX11", "url": "https://www.uniprot.org/uniprotkb/Q3SX11" } ], "pmid": "" }, { "name": "maturation of LSU-rRNA", "id": "GO:0000470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000470", "evidence": [ { "database": "UniProtKB", "id": "Q3SX11", "url": "https://www.uniprot.org/uniprotkb/Q3SX11" } ], "pmid": "" }, { "name": "ribosomal large subunit biogenesis", "id": "GO:0042273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042273", "evidence": [ { "database": "UniProtKB", "id": 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"database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "2FTC", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=2FTC&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "3IY9", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=3IY9&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "Q2TA12", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q2TA12*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002171", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002171", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008991", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008991", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014722", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014722", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022669", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022669", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514403", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514403", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EHNKEHV", "url": "https://omabrowser.org/oma/group/EHNKEHV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TA12", "url": "https://www.orthodb.org/?gene=Q2TA12", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13691", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13691", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13691:SF73", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13691:SF73", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00002ftc", "url": "https://www.rcsb.org/structure/pdb_00002ftc", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00003iy9", "url": "https://www.rcsb.org/structure/pdb_00003iy9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2FTC", "url": "https://www.rcsb.org/structure/2FTC", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3IY9", "url": "https://www.rcsb.org/structure/3IY9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00181", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00181", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03947", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03947", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9937383", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001035617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035617", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SK15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK15-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG73-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TA12", "url": "https://www.uniprot.org/uniprotkb/Q2TA12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TA12-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA12-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALRVVTRALGSLSLTPRIAAVPGPSLLPAAQVTNNVLLQLPSASMLLPSRPLLTSVALSAKFVSWKSRTKYTTMPVKMRKSGGRNHTGRIQVHGIGGGHKQRYRMIDFLRFRPEQESKPGPFEEKVIVVRYDPCRSADIALVAGGNRKRWIIATENMKAGDTILNSDHIGRMAVAAREGDAHPLGALPVGTLINNVESEPGRGAQYIRAAGTCGVLLRKVNGTAIIQLPSKRQMQVLETCTATVGRVSNVDHNKRVIGKAGRNRWLGKRPNSGRWHRKGGWAGRKIRPLPPMKSYVKLPSAAAQN", "length": 306, "header": "sp|Q2TA12-1|RM02_BOVIN Isoform 1 of Large ribosomal subunit protein uL2m OS=Bos taurus OX=9913 GN=MRPL2 PE=1 SV=2 CANONICAL=Q2TA12-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SK15-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA12/entry#A0AAA9SK15-1", "sequence": { "sequence": "MALRVVTRALGSLSLTPRIAAVPGPSLLPAAQVTNNVLLQLPSASMLLPSRPLLTSVALSAKFVSWKSRTKYTTMPVKMRKSGGRNHTGAGDVHSHSGPSLQR", "length": 103, "header": "tr|A0AAA9SK15-1|RM02_BOVIN Computationally mapped isoform of Large ribosomal subunit protein uL2m OS=Bos taurus OX=9913 GN=MRPL2 PE=1 SV=1 CANONICAL=Q2TA12-1" }, "locus": { "chromosome": "23", "start_pos": 16688007, "end_pos": 16684092, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129052.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129052.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082930.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082930.1" } ] } }, { "isoform_ac": "A0AAA9TG73-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA12/entry#A0AAA9TG73-1", "sequence": { "sequence": "MALRVVTRALGSLSLTPRIAAVPGPSLLPAAQVTNNVLLQLPSASMLLPSRPLLTSVALSAKFVSWKSRTKYTTMPVKMRKSGGRNHTGRIQVHGIGGGHKQRYRMIDFLRFRPEQESKPGPFEEKVIVVRYDPCRSADIALVAGGNRKRWIIATENMKAGDTILNSDHIGRMAVAAREGDAHPLGALPVGTLINNVESEPGRGAQYIRAAGAGDVHSHSGPSLQR", "length": 226, "header": "tr|A0AAA9TG73-1|RM02_BOVIN Computationally mapped isoform of Large ribosomal subunit protein uL2m OS=Bos taurus OX=9913 GN=MRPL2 PE=1 SV=1 CANONICAL=Q2TA12-1" }, "locus": { "chromosome": "23", "start_pos": 16688007, "end_pos": 16684092, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119704.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119704.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097562.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097562.1" } ] } }, { "isoform_ac": "Q2TA12-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA12/entry#Q2TA12-1", "sequence": { "sequence": "MALRVVTRALGSLSLTPRIAAVPGPSLLPAAQVTNNVLLQLPSASMLLPSRPLLTSVALSAKFVSWKSRTKYTTMPVKMRKSGGRNHTGRIQVHGIGGGHKQRYRMIDFLRFRPEQESKPGPFEEKVIVVRYDPCRSADIALVAGGNRKRWIIATENMKAGDTILNSDHIGRMAVAAREGDAHPLGALPVGTLINNVESEPGRGAQYIRAAGTCGVLLRKVNGTAIIQLPSKRQMQVLETCTATVGRVSNVDHNKRVIGKAGRNRWLGKRPNSGRWHRKGGWAGRKIRPLPPMKSYVKLPSAAAQN", "length": 306, "header": "sp|Q2TA12-1|RM02_BOVIN Isoform 1 of Large ribosomal subunit protein uL2m OS=Bos taurus OX=9913 GN=MRPL2 PE=1 SV=2 CANONICAL=Q2TA12-1" }, "locus": { "chromosome": "23", "start_pos": 16688007, "end_pos": 16683926, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016951.5", "url": "https://www.ensembl.org/id/ENSBTAT00000016951.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016951.4", "url": "https://www.ensembl.org/id/ENSBTAP00000016951.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Suzuki T, Terasaki M, Takemoto-Hori C, Hanada T, Ueda T, Wada A, Watanabe K", "evidence": [ { "database": "UniProtKB", "id": "Q2TA12", "url": "https://www.uniprot.org/uniprotkb/Q2TA12" } ], "reference": [ { "type": "PubMed", "id": "11279069", "url": "https://glygen.org/publication/PubMed/11279069" } ] }, { "title": "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Koc E C, Burkhart W, Blackburn K, Moyer M B, Schlatzer D M, Moseley A, Spremulli L L", "evidence": [ { "database": "UniProtKB", "id": "Q2TA12", "url": "https://www.uniprot.org/uniprotkb/Q2TA12" } ], "reference": [ { "type": "PubMed", "id": "11551941", "url": "https://glygen.org/publication/PubMed/11551941" } ] }, { "title": "A structural model for the large subunit of the mammalian mitochondrial ribosome.", "journal": "J. Mol. Biol.", "date": "2006", "authors": "Mears Jason A, Sharma Manjuli R, Gutell Robin R, McCook Amanda S, Richardson Paul E, Caulfield Thomas R, Agrawal Rajendra K, Harvey Stephen C", "evidence": [ { "database": "UniProtKB", "id": "Q2TA12", "url": "https://www.uniprot.org/uniprotkb/Q2TA12" } ], "reference": [ { "type": "PubMed", "id": "16510155", "url": "https://glygen.org/publication/PubMed/16510155" } ] } ], "pathway": [ { "id": "bta:514403", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514403", "resource": "KEGG Pathway" }, { "id": "R-BTA-5389840", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-9937383", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "resource": "Reactome", "description": "Mitochondrial ribosome-associated quality control" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A143-1", "protein_name": "Large ribosomal subunit protein uL2m", "gene_name": "MRPL2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALRVLTRALSSLSLTPRIAVAPGLNLLPAVQVTNNVLLTLPSGLMSLPCRPILTSVALSATSVSWKSRTKYTVMPVKMRKSGGRNHTGQIQVHGIGGGHKQRYRMIDFLRFRPEHESKPGPFEEKVIAVRYDPCRSADIALVAGGNRKRWIIATENMKAGDTVLNSDHIGRMAVAAREGDAHPLGALPVGTLINNVESEPGRGAQYIRAAGTCGVLLRKVNGTAIIQLPSKRQMQVLETCIATVGRVSNVDHNKRVIGKAGRNRWLGKRPNSGLWQRKGGWAGRKIRPLPPMKSYVKLPSAAAQS", "length": 306 }, "evidence": [ { "id": "Q2TA12", "url": "https://omabrowser.org/oma/group/Q2TA12/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M1P304-1", "protein_name": "Large ribosomal subunit protein uL2m", "gene_name": "mrpl2", "tax_id": 7955, "organism": "Danio rerio", 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"length": 293 }, "evidence": [ { "id": "Q2TA12", "url": "https://omabrowser.org/oma/group/Q2TA12/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q498T4-1", "protein_name": "Large ribosomal subunit protein uL2m", "gene_name": "Mrpl2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALCALASALRSLSLASPAITARVPTLLPVGQSNVLLQLPSALALPAHRPVHMSADRSAKFVSWKSRIKYTVKPVKMRKSGGRDHTGRIRVHGIGGGHKQNYRMIDFLRFRPEKGTEPEPFEEKVVVVRYDPCRSADIALVAGGSRKRWIIATENMKAGDTILNSNHIGRMAVAAQEGDAHPLGALPVGTLINNVESEPGRGAQYIRAAGTCGVLLRKVNGTAIIQLPSKRQMQVLESCTATVGRVSNVNHNQRVIGKAGRNRWLGKRPNSGLWQRKGGWAGRKIRPLPPMKSYVKLPSAAAQS", "length": 304 }, "evidence": [ { "id": "Q2TA12", "url": "https://omabrowser.org/oma/group/Q2TA12/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5T653-1", "protein_name": "Large ribosomal subunit protein uL2m", "gene_name": "MRPL2", "tax_id": 9606, "organism": "Homo 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"MALCALTSALRSLSLASAAITARVPTLLPAAQIQSNVLLQLPPALVSPSYRPVHMSADRSAKFVSWKSRTKYTVKPVKMRKSGGRDHTGRIRVHGIGGGHKQNYRMIDFLRFRPEKEKAPEPFEEKVVVVRYDPCRSADIALVAGGSRKRWIIATENMKAGDTILNSNHIGRMAVAAQEGDAHPLGALPVGTLINNVESEPGRGAQYIRAAGTCGVLLRKVNGTAIIQLPSKRQMQVLESCTATVGRVSNVNHNQRVIGKAGRNRWLGKRPNSGLWQRKGGWAGRKIRPLPPMKSYVKLPSAAAQN", "length": 306 }, "evidence": [ { "id": "Q2TA12", "url": "https://omabrowser.org/oma/group/Q2TA12/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VTF8-1", "protein_name": "Mitochondrial ribosomal protein L2", "gene_name": "mRpL2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MQSVTRLLSTTLTIQTPFRTAPAFLQQLRGKTKVVEKPKPGAGQQFRRTVHFPEKYTVEPLKITHLAGRDPVSGRLVAKGIGGGIKQQYRWVKWVRDGPTEGAQEELVLEVLRDGCRTAKVALVAVGDELKYILATENMKAGDILKTSRFIPRIPVRPNEGDAYPLGALPVGTRIHCLEKNPGQMCHLIHAAGTFGTILRKFDEKVVVQLPSKREFAFQRTCMATVGRLSNPEHNKEHVGSAQRMREMGNRPRSGLWKRKEGKHGRKIRRLPPMTTISPPAPPKEEAIKLTLPL", "length": 294 }, "evidence": [ { "id": "Q2TA12", "url": "https://omabrowser.org/oma/group/Q2TA12/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "Q2TA12", "url": "https://www.uniprot.org/uniprotkb/Q2TA12" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q2TA12", "url": "https://www.uniprot.org/uniprotkb/Q2TA12" } ], "pmid": "" }, { "name": "organelle membrane", "id": "GO:0031090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031090", "evidence": [ { "database": "UniProtKB", "id": "Q2TA12", "url": "https://www.uniprot.org/uniprotkb/Q2TA12" } ], "pmid": "" }, { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "Q2TA12", "url": "https://www.uniprot.org/uniprotkb/Q2TA12" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q2TA12", "url": "https://www.uniprot.org/uniprotkb/Q2TA12" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q2TA12", "url": "https://www.uniprot.org/uniprotkb/Q2TA12" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q2TA12", "url": "https://www.uniprot.org/uniprotkb/Q2TA12" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitochondrial translation", "id": "GO:0032543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032543", "evidence": [ { "database": "UniProtKB", "id": "Q2TA12", "url": "https://www.uniprot.org/uniprotkb/Q2TA12" } ], "pmid": "" }, { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q2TA12", "url": "https://www.uniprot.org/uniprotkb/Q2TA12" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" }, { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TA12-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 306, "overlap": "1.0", "method": "AlphaFold", 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"sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3T196-1", "uniprot_ac": "Q3T196", "uniprot_id": "YIF1A_BOVIN", "mass": { "chemical_mass": 32102.0, "monoisotopic_mass": 32102.0 }, "refseq": { "ac": "NP_001029441", "name": "protein YIF1A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029441" }, "gene_names": [ { "name": "YIF1A", "type": "recommended", "evidence": [ { "id": "Q3T196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T196" } ] }, { "name": "YIF1A", "type": "synonym", "evidence": [ { "id": "NP_001029441", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029441" } ] } ], "protein_names": [ { "name": "Protein YIF1A", "type": "recommended", "evidence": [ { "id": "Q3T196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T196/entry#names_and_taxonomy" } ] }, { "name": "YIP1-interacting factor homolog A", "type": "synonym", "evidence": [ { "id": "NP_001029441", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029441" }, { "id": "Q3T196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T196/entry#names_and_taxonomy" } ] }, { "name": "protein YIF1A", "type": "synonym", "evidence": [ { "id": "NP_001029441", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029441" } ] } ], "function": [ { "annotation": "Has a role in transport between endoplasmic reticulum and Golgi.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK96#function" }, { "database": "UniProtKB", "id": "RU368073", "url": "https://www.uniprot.org/uniprotkb/RU368073#function" }, { "database": "UniProtKB", "id": "A0AAF6YMS1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMS1#function" } ] }, { "annotation": "Possible role in transport between endoplasmic reticulum and Golgi.", "evidence": [ { "database": "UniProtKB", "id": "Q3T196", "url": "https://www.uniprot.org/uniprotkb/Q3T196#function" }, { "database": "UniProtKB", "id": "O95070", "url": "https://www.uniprot.org/uniprotkb/O95070#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T196", "url": "https://www.uniprot.org/uniprotkb/Q3T196" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "YIF1A", "url": "https://www.uniprot.org/uniprotkb/Q3T196", "locus": { "chromosome": "29", "start_pos": 44338707, "end_pos": 44342756, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004829", "url": "https://www.ensembl.org/id/ENSBTAG00000004829" } ] } } ], "crossref": [ { "id": "Q3T196", "url": "https://alphafold.ebi.ac.uk/entry/Q3T196", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004829", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004829", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506336", "url": "https://www.ncbi.nlm.nih.gov/gene/506336", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506336", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506336", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NWEVRYS", "url": "https://omabrowser.org/oma/group/NWEVRYS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T196", "url": "https://www.orthodb.org/?gene=Q3T196", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14083", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14083", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14083:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14083:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03878", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03878", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029441", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029441", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SK96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YMS1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YMS1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMS1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T196", "url": "https://www.uniprot.org/uniprotkb/Q3T196", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T196-1", "url": "https://www.uniprot.org/uniprotkb/Q3T196-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAYHSGYGAHGSKHRARAAPDPPPLFDDTSGGYSSQPGGYPAPGADVAFNVNHLLGDPMANMAMAYGSSIASHGKDMMNKELHRFVSVNKLKYFFAVDTAYVAKKLGLLVFPYTHQNWEVQYSRDVPLPPRQDLNAPDLYIPTMAFITYVLLAGMALGIQKRFSPEVLGLCASTALVWVVMEVLALLLGIYLATVRSDLSTFHLLAYSGYKYVGMILSVLTGLLFGSDGYYVALAWTSSALMYFIVRSLRTAALGPDSMGGPAPRQRLQLYLTLGAAAFQPLIIYWLTFHLVR", "length": 293, "header": "sp|Q3T196-1|YIF1A_BOVIN Isoform 1 of Protein YIF1A OS=Bos taurus OX=9913 GN=YIF1A PE=2 SV=1 CANONICAL=Q3T196-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SK96-1", "url": "https://www.uniprot.org/uniprotkb/Q3T196/entry#A0AAA9SK96-1", "sequence": { "sequence": "MAYHSGYGAHGSKHRARAAPDPPPLFDDTSGGYSSQPGGYPAPGADVAFNVNHLLGDPMANMAMAYGSSIASHGKDMMNKELHRFVSVNKLKYFFAVDTAYVAKKLGLLVFPYTHQNWEVQYSRDVPLPPRQDLNAPDLYIPTMAFITYVLLAGMALGIQKRMILSVLTGLLFGSDGYYVALAWTSSALMYFIVRSLRTAALGPDSMGGPAPRQRLQLYLTLGAAAFQPLIIYWLTFHLVR", "length": 241, "header": "tr|A0AAA9SK96-1|YIF1A_BOVIN Computationally mapped isoform of Protein YIF1A OS=Bos taurus OX=9913 GN=YIF1A PE=2 SV=1 CANONICAL=Q3T196-1" }, "locus": { "chromosome": "29", "start_pos": 44342589, "end_pos": 44338764, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096846.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096846.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084348.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084348.1" } ] } }, { "isoform_ac": "A0AAF6YMS1-1", "url": "https://www.uniprot.org/uniprotkb/Q3T196/entry#A0AAF6YMS1-1", "sequence": { "sequence": "MAYHSGYGAHGSKHRARAAPDPPPLFDDTSGGYSSQPGGYPAPGADVAFNVNHLLGDPMANMAMAYGSSIASHGKDMMNKELHRFVSVNKLKYFFAVDTAYVAKKLGLLVFPYTHQNWEVQYSRDVPLPPRQDLNAPDLYIPTMAFITYVLLAGMALGIQKRFSPEVLGLCASTALVWVVMEVLALLLGIYLATVRSDLSTFHLLAYSGYKYVGMILSVLTGLLFGSDGYYVALAWTSSALMYFIVSPGLAPLCLGSAADRPPPPGPASALLSSRCALCEQQPWDLTAWGARPPDNVSSST", "length": 301, "header": "tr|A0AAF6YMS1-1|YIF1A_BOVIN Computationally mapped isoform of Protein YIF1A OS=Bos taurus OX=9913 GN=YIF1A PE=2 SV=1 CANONICAL=Q3T196-1" }, "locus": { "chromosome": "29", "start_pos": 44342589, "end_pos": 44338829, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006343.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006343.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006343.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006343.5" } ] } }, { "isoform_ac": "Q3T196-1", "url": "https://www.uniprot.org/uniprotkb/Q3T196/entry#Q3T196-1", "sequence": { "sequence": "MAYHSGYGAHGSKHRARAAPDPPPLFDDTSGGYSSQPGGYPAPGADVAFNVNHLLGDPMANMAMAYGSSIASHGKDMMNKELHRFVSVNKLKYFFAVDTAYVAKKLGLLVFPYTHQNWEVQYSRDVPLPPRQDLNAPDLYIPTMAFITYVLLAGMALGIQKRFSPEVLGLCASTALVWVVMEVLALLLGIYLATVRSDLSTFHLLAYSGYKYVGMILSVLTGLLFGSDGYYVALAWTSSALMYFIVRSLRTAALGPDSMGGPAPRQRLQLYLTLGAAAFQPLIIYWLTFHLVR", "length": 293, "header": "sp|Q3T196-1|YIF1A_BOVIN Isoform 1 of Protein YIF1A OS=Bos taurus OX=9913 GN=YIF1A PE=2 SV=1 CANONICAL=Q3T196-1" }, "locus": { "chromosome": "29", "start_pos": 44342589, "end_pos": 44338764, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104810.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104810.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099978.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099978.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 12, "end_pos": 12, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T196", "url": "https://www.uniprot.org/uniprotkb/Q3T196" } ], "site_lbl": "Ser12" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506336", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506336", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1TTW2-1", "protein_name": "Protein YIF1", "gene_name": "YIF1A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAYHSGYGAHGSKHRARAAPDPPSLFDDTSGGYSSQPGGYPAPGADVAFNVNHLLGDPMANVAMAYGSSIASHGKDMVHKELHRFVSVNKLKYFFAVDTAYVAKKLGLLVFPYTHQNWEVQYSRDVPLPPRQDLNAPDLYIPTMAFITYVLLAGMALGIQKRFSPEVLGLCASTALVWVVMEVLALLLGIYLATVRSDLSTFHLLAYSGYKYVGMILSVLTGLLFGSDGYYVALAWTSSALMYFIVRSLRTAALGSDSMGGPAPRQRLQLYLTLGAAAFQPLIIYWLTFHLVR", "length": 293 }, "evidence": [ { "id": "Q3T196", "url": "https://omabrowser.org/oma/group/Q3T196/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "B0BMV4-1", "protein_name": "Protein YIF1", "gene_name": "Yif1a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAYHSGYGVHGSKHRTRAAPNPPPLFDDTSGGYSSQLGGYPAPGADVAFNVNNLLGDPVANMAMAYGSSIASQGKDIVHKELHRFVSINKLKYFFAVDTAYVAKKLGLLVFPYTHQNWKVQYSHDVPLPPRKDLNAPDLYIPTMAFITYVLLAGMALGIQQRFSPEVLGLCASTALVWVLMEVLALLLGLYLATVRSELGTFHLLAYSGYKYVGMILSVLTGLLFGSDGYYVALAWTSSALMYFTVRSLRTAASGPDSMGGPTPRQHLQLYLTLGAAAFQPLIIYWLTFHLVR", "length": 293 }, "evidence": [ { "id": "Q3T196", "url": "https://omabrowser.org/oma/group/Q3T196/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F4J8C0-1", "protein_name": "Integral membrane HRF1 family protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MYNNMGPRPGMAMPQANPQPSPFGNPFSGPGSGLIRSGLGAYGEKIFGSSSEYVQSNISRYFSDPQYYFQVNDQYVRNKLKIVLLPFLHRGHWTRISEPVGGRLSYKPPIYDINAPDLYIPLMAFGTYVVLAGLSLGLYGKFTPEALNWLFVKGMVGWFLQVMLLKITLLSLGSGEAPLLDIVAYAGYTFTGLCLAVLGKIIWGYSYYVLIPWTCLCTGVFLVKTMKRVLFAESRSYDSSRHHYLLIFVALAQFPLLIWLGNISVNWLF", "length": 269 }, "evidence": [ { "id": "Q3T196", "url": "https://omabrowser.org/oma/group/Q3T196/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "G3I2E7-1", "protein_name": "Protein YIF1", "gene_name": "Yif1a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAYHSGYGAHGSKHRTRAAPDSPPLFDDTSGGYSSHPGGYPAPGADVAFSVNHLLGDPVANMAMAYGSSIASQGKDIVHKELHRFVSVNKLKYFFAVDTAYVAKKLGLLVFPYTHQNWKMQYSHDVPLPPRKDLNAPDLYIPTMAFITYVLLAGTALGIQKRFSPEVLGLCASTALVWVFMEVLALLLGLYLATVRSELSTFHLLAYSGYKYVGMILSVITGLLFGSDGYYVALAWTSSALMYFIVRSLRTAALGPDSMGGPAPGQRLQLYLTLGAAAFQPLIIYWLTFHLVR", "length": 293 }, "evidence": [ { "id": "Q3T196", "url": "https://omabrowser.org/oma/group/Q3T196/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O95070-1", "protein_name": "Protein YIF1A", "gene_name": "YIF1A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAYHSGYGAHGSKHRARAAPDPPPLFDDTSGGYSSQPGGYPATGADVAFSVNHLLGDPMANVAMAYGSSIASHGKDMVHKELHRFVSVSKLKYFFAVDTAYVAKKLGLLVFPYTHQNWEVQYSRDAPLPPRQDLNAPDLYIPTMAFITYVLLAGMALGIQKRFSPEVLGLCASTALVWVVMEVLALLLGLYLATVRSDLSTFHLLAYSGYKYVGMILSVLTGLLFGSDGYYVALAWTSSALMYFIVRSLRTAALGPDSMGGPVPRQRLQLYLTLGAAAFQPLIIYWLTFHLVR", "length": 293 }, "evidence": [ { "id": "Q3T196", "url": "https://omabrowser.org/oma/group/Q3T196/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54XV4-1", "protein_name": "Protein YIF1", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSHNLGYMEYNKGNTGYNSGENYPSMDQYNYGQGNMGNMGNMGQQYQPPQQQQQPPQQQQQHNSGFGFPSPTLYNMNAQQQQQQQQQHQQQQHHNQQTSPMYGNNGGFNQFNNNDNSHYSPPQQGDMSRQFISQISDNPLTQAGLTYGLNYGQTLFSGGKQYVDSNFGKYFSFSTLKSYFNVNNSYVFNKIKLLIFPYTQKTWKRRIGRTSDVDSYLPPRDDINAPDLYIPLMAFITYFLLYGFQMGMEKKFSPDYLGACITKGIVFWAIELLIFKCGFFFSNSNSIPFYDMISYSGYKYVLMVIFQIATILLGSYVSYIIKCVLSVSIAFFMLKTLRLVFSSVSGAHDHISPDYHESGKIKNYFVFGFSVAQALLCFLV", "length": 380 }, "evidence": [ { "id": "Q3T196", "url": "https://omabrowser.org/oma/group/Q3T196/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6PC24-1", "protein_name": "Protein YIF1A", "gene_name": "yif1a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNFQQQGYRATKPRARASPPTGGPMLFDDTSSGPPPMNNQNYYSSGYNMAEMPAGGQEPGVGNIFADPMANAAMMYGSTLANQGKDIVNKEINRFMSVNKLKYFFAVDTKYVMKKLLLLMFPYTHQDWEVRYHRDTPLTPRHDVNAPDLYIPTMAFITYILLAGMALGIQKRFSPEVLGLCASTALVWMIIEVLVMLLSLYLLTVHTDLSTFDLVAYSGYKYVGMILTVFCGLLFGSDGYYVALAWSSCALMFFIVRSLKMKILSSISADSMGAGASAKPRFRLYITVASAAFQPFIIYWLTAHLVR", "length": 307 }, "evidence": [ { "id": "Q3T196", "url": "https://omabrowser.org/oma/group/Q3T196/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q91XB7-1", "protein_name": "Protein YIF1A", "gene_name": "Yif1a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAYHSAYGVHGSKHRTRAAPDPPPLFDDTSGGYSSQLGGYPAPGADVAFSVNNLLGDPVANMAMAYGTSIASQGKDIVHKELHRFVSVNKLKYFFAVDTAYVAKKLGLLVFPYTHQNWKMQYSHDVPLPPRKDLNAPDLYIPTMAFITYVLLAGMALGIQQRFSPEVLGLCASTALVWVFMEVLALLLGLYLATVRSELSTFHLLAYSGYKYVGMILSVLTGLLFGSDGYYVALAWTSSALMYFIVRSLRTAASGPDSMGGPAPRQRLQLYLTLGAAAFQPLIIYWLTFHLVR", "length": 293 }, "evidence": [ { "id": "Q3T196", "url": "https://omabrowser.org/oma/group/Q3T196/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q3T196", "url": "https://www.uniprot.org/uniprotkb/Q3T196" } ], "pmid": "" }, { "name": "COPII-coated ER to Golgi transport vesicle", "id": "GO:0030134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030134", "evidence": [ { "database": "UniProtKB", "id": "Q3T196", "url": "https://www.uniprot.org/uniprotkb/Q3T196" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3T196", "url": "https://www.uniprot.org/uniprotkb/Q3T196" } ], "pmid": "" }, { "name": "endoplasmic reticulum-Golgi intermediate compartment membrane", "id": "GO:0033116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033116", "evidence": [ { "database": "UniProtKB", "id": "Q3T196", "url": "https://www.uniprot.org/uniprotkb/Q3T196" } ], "pmid": "" }, { "name": "endoplasmic reticulum-Golgi intermediate compartment", "id": "GO:0005793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005793", "evidence": [ { "database": "UniProtKB", "id": "Q3T196", "url": "https://www.uniprot.org/uniprotkb/Q3T196" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q3T196", "url": "https://www.uniprot.org/uniprotkb/Q3T196" } ], "pmid": "" }, { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "Q3T196", "url": "https://www.uniprot.org/uniprotkb/Q3T196" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T196-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 293, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T196-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T196" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 12 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ13-1", "uniprot_ac": "Q3SZ13", "uniprot_id": "UQCC2_BOVIN", "mass": { "chemical_mass": 15975.0, "monoisotopic_mass": 15975.0 }, "refseq": { "ac": "NP_001193543", "name": "ubiquinol-cytochrome c reductase complex assembly factor 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193543" }, "gene_names": [ { "name": "UQCC2", "type": "recommended", "evidence": [ { "id": "Q3SZ13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13" } ] }, { "name": "C23H6orf125", "type": "synonym", "evidence": [ { "id": "NP_001193543", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193543" } ] }, { "name": "MNF1", "type": "synonym", "evidence": [ { "id": "NP_001193543", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193543" }, { "id": "Q3SZ13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13" } ] }, { "name": "UQCC2", "type": "synonym", "evidence": [ { "id": "NP_001193543", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193543" } ] } ], "protein_names": [ { "name": "Ubiquinol-cytochrome c reductase complex assembly factor 2", "type": "recommended", "evidence": [ { "id": "Q3SZ13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13/entry#names_and_taxonomy" } ] }, { "name": "Mitochondrial nucleoid factor 1", "type": "synonym", "evidence": [ { "id": "Q3SZ13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13/entry#names_and_taxonomy" } ] }, { "name": "Mitochondrial protein M19", "type": "synonym", "evidence": [ { "id": "Q3SZ13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial nucleoid factor 1", "type": "synonym", "evidence": [ { "id": "NP_001193543", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193543" } ] }, { "name": "ubiquinol-cytochrome c reductase complex assembly factor 2", "type": "synonym", "evidence": [ { "id": "NP_001193543", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193543" } ] } ], "function": [ { "annotation": "Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ13", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13#function" }, { "database": "UniProtKB", "id": "Q9BRT2", "url": "https://www.uniprot.org/uniprotkb/Q9BRT2#function" }, { "database": "UniProtKB", "id": "Q9CQY6", "url": "https://www.uniprot.org/uniprotkb/Q9CQY6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ13", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UQCC2", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13", "locus": { "chromosome": "23", "start_pos": 7814520, "end_pos": 7840352, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000054726", "url": "https://www.ensembl.org/id/ENSBTAG00000054726" } ] } } ], "crossref": [ { "id": "Q3SZ13", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ13", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000054726", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054726", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100607974", "url": "https://www.ncbi.nlm.nih.gov/gene/100607974", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR037698", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037698", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100607974", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100607974", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CEEWPKD", "url": "https://omabrowser.org/oma/group/CEEWPKD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ13", "url": "https://www.orthodb.org/?gene=Q3SZ13", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34260", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34260", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34260:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34260:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF20180", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20180", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193543", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SKR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKR4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ13", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ13-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ13-2", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASRYRRFLKLCEEWPVDETKRGRDLGAYLRQRVAQAFREGENTQVAEPEACDEMYESLARLHSNYYKHKYPRPRETSFSGLSLEEYKLILSTDTLDEFKEMNKGTWKKLQEKFAPGSPEGKHTAWARALPRPRT", "length": 136, "header": "sp|Q3SZ13-1|UQCC2_BOVIN Isoform 1 of Ubiquinol-cytochrome c reductase complex assembly factor 2 OS=Bos taurus OX=9913 GN=UQCC2 PE=2 SV=1 CANONICAL=Q3SZ13-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKR4-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13/entry#A0AAA9SKR4-1", "sequence": { "sequence": "MAASRYRRFLKLCEEWPVDETKRGRDLGAYLRQRVAQAFREGENTQYPRPRETSFSGLSLEEYKLILSTDTLDEFKEMNKGTWKKLQEKFAPGSPEGKHTAWARALPRPRT", "length": 111, "header": "tr|A0AAA9SKR4-1|UQCC2_BOVIN Computationally mapped isoform of Ubiquinol-cytochrome c reductase complex assembly factor 2 OS=Bos taurus OX=9913 GN=UQCC2 PE=2 SV=1 CANONICAL=Q3SZ13-1" }, "locus": { "chromosome": "23", "start_pos": 7840307, "end_pos": 7814578, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091008.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091008.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085879.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085879.1" } ] } }, { "isoform_ac": "Q3SZ13-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13/entry#Q3SZ13-1", "sequence": { "sequence": "MAASRYRRFLKLCEEWPVDETKRGRDLGAYLRQRVAQAFREGENTQVAEPEACDEMYESLARLHSNYYKHKYPRPRETSFSGLSLEEYKLILSTDTLDEFKEMNKGTWKKLQEKFAPGSPEGKHTAWARALPRPRT", "length": 136, "header": "sp|Q3SZ13-1|UQCC2_BOVIN Isoform 1 of Ubiquinol-cytochrome c reductase complex assembly factor 2 OS=Bos taurus OX=9913 GN=UQCC2 PE=2 SV=1 CANONICAL=Q3SZ13-1" }, "locus": { "chromosome": "23", "start_pos": 7840307, "end_pos": 7814578, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047742.3", "url": "https://www.ensembl.org/id/ENSBTAT00000047742.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044920.1", "url": "https://www.ensembl.org/id/ENSBTAP00000044920.1" } ] } }, { "isoform_ac": "Q3SZ13-2", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13/entry#Q3SZ13-2", "sequence": { "sequence": "MVVQDNVDAPGVPLEPFLHQVGGHLSVMRYDEHTVCKPLISREQRFYESLPLAMKRFTPQYKGTITVHLQKDSRGRLSLVANPLTENRGPFTVSTESAAVAIWQTLQQTTGGSALPLAQWQHPQRAHSLKESPATALLRSELHLKAQVPSLVEDANGNLTEKGSFNPWGLHCHQAHLSRLCAEYPENKRHRFLLLENVVSQYKHPCILDLKMGTRQHGDDASEEKKARHMRKCAQSTSAHLGMRICGMQVAEPEACDEMYESLARLHSNYYKHKYPRPRETSFSGLSLEEYKLILSTDTLDEFKEMNKGTWKKLQEKFAPGSPEGKHTAWARALPRPRT", "length": 339, "header": "sp|Q3SZ13-2|UQCC2_BOVIN Isoform 2 of Ubiquinol-cytochrome c reductase complex assembly factor 2 OS=Bos taurus OX=9913 GN=UQCC2 PE=2 SV=1 CANONICAL=Q3SZ13-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ13", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "A whole-genome assembly of the domestic cow, Bos taurus.", "journal": "Genome Biol.", "date": "2009", "authors": "Zimin Aleksey V, Delcher Arthur L, Florea Liliana, Kelley David R, Schatz Michael C, Puiu Daniela, Hanrahan Finnian, Pertea Geo, Van Tassell Curtis P, Sonstegard Tad S, Mar\u00e7ais Guillaume, Roberts Michael, Subramanian Poorani, Yorke James A, Salzberg Steven L", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ13", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13" } ], "reference": [ { "type": "PubMed", "id": "19393038", "url": "https://glygen.org/publication/PubMed/19393038" } ] } ], "pathway": [ { "id": "bta:100607974", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100607974", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B747-1", "protein_name": "Mitochondrial nucleoid factor 1", "gene_name": "UQCC2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAASRYRRFLRLCEEWPLDETKRGRDLGAYLRQRVAQAFREGENTQIAEPEACDQMYESLARLHSNYYKHKYPRPRDTSFSGLSLEEYKLILSTDTLDEFKEMDKGVWKKLQERFAPRNPEEKHKAWARALSRPRT", "length": 136 }, "evidence": [ { "id": "Q3SZ13", "url": "https://omabrowser.org/oma/group/Q3SZ13/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A6H2EGA2-1", "protein_name": "Mitochondrial nucleoid factor 1", "gene_name": "Dmel\\CG46459", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSAQYQRFLKVLEKWPAEKSKVGRDLGEQIRKQVTKLTSLEGGATDKELDRQINSLERLSNNVYAKKYPRTFESTATGLTAAQCSQVLSSEFLQYLNEDSKKKK", "length": 104 }, "evidence": [ { "id": "Q3SZ13", "url": "https://omabrowser.org/oma/group/Q3SZ13/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "B5DFN3-1", "protein_name": "Ubiquinol-cytochrome-c reductase complex assembly factor 2", "gene_name": "Uqcc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAALRYRRFLKLCEEWPVDETKRGRDLGAYLRQRVAQAFREGENTQVAEPEACDQMYESLARLHSNYYKHKYPRPRDTSFSGLSVEEYKLILSTDTLEEFQEMNKSVWRKLQEKFAPTRPEEKHRAWTRVLSRPRT", "length": 136 }, "evidence": [ { "id": "Q3SZ13", "url": "https://omabrowser.org/oma/group/Q3SZ13/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3I6V1-1", "protein_name": "Mitochondrial nucleoid factor 1", "gene_name": "LOC100773172", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAALRYRRFLKLCEEWPVDETKRGRDLGAYLRKRVAQAFREGENTQVAEPEACDQMYESLARLHSNYYKHKYPRPRDTSFSGLSVEEYKVILSTDTMEEFQELDKSVWKKLQEKFAPRPEEKHKAWARVLSRPRT", "length": 135 }, "evidence": [ { "id": "Q3SZ13", "url": "https://omabrowser.org/oma/group/Q3SZ13/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6PBU7-1", "protein_name": "Ubiquinol-cytochrome-c reductase complex assembly factor 2", "gene_name": "uqcc2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSATRYRRFLKLCEEWPKDESKKGRDLGTFLRQRVASAFREGENTQISDPEKCDQMYESLARINSNVYKEKFPRAKDTSFTGVTVEECRLLLATGSMQQTDEEKKGLWKTLMERFSSKPEDVPPEKAEK", "length": 129 }, "evidence": [ { "id": "Q3SZ13", "url": "https://omabrowser.org/oma/group/Q3SZ13/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9BRT2-1", "protein_name": "Ubiquinol-cytochrome c reductase complex assembly factor 2", "gene_name": "UQCC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAASRYRRFLKLCEEWPVDETKRGRDLGAYLRQRVAQAFREGENTQVAEPEACDQMYESLARLHSNYYKHKYPRPRDTSFSGLSLEEYKLILSTDTLEELKEIDKGMWKKLQEKFAPKGPEEDHKA", "length": 126 }, "evidence": [ { "id": "Q3SZ13", "url": "https://omabrowser.org/oma/group/Q3SZ13/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CQY6-1", "protein_name": "Ubiquinol-cytochrome c reductase complex assembly factor 2", "gene_name": "Uqcc2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAALRYRRFLKLCEEWPVDETKRGRDLGAYLRQRVAQAFREGENTQIAEPEACDQMYESLARLHSNYYKHKYPRPRDTSFSGLSVEEYKLILSTDTLEEFQEMNKSMWKKLQEKFAPTRPEEKHKAWTRVLSRPRT", "length": 136 }, "evidence": [ { "id": "Q3SZ13", "url": "https://omabrowser.org/oma/group/Q3SZ13/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ13", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ13", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13" } ], "pmid": "" }, { "name": "mitochondrial intermembrane space", "id": "GO:0005758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005758", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ13", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ13", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13" } ], "pmid": "" }, { "name": "mitochondrial nucleoid", "id": "GO:0042645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042645", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ13", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "regulation of insulin secretion", "id": "GO:0050796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050796", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ13", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13" } ], "pmid": "" }, { "name": "regulation of oxidative phosphorylation", "id": "GO:0002082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002082", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ13", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13" } ], "pmid": "" }, { "name": "mitochondrial respiratory chain complex III assembly", "id": "GO:0034551", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034551", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ13", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13" } ], "pmid": "" }, { "name": "positive regulation of mitochondrial translation", "id": "GO:0070131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070131", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ13", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13" } ], "pmid": "" }, { "name": "regulation of skeletal muscle cell differentiation", "id": "GO:2001014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001014", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ13", "url": "https://www.uniprot.org/uniprotkb/Q3SZ13" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ13-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 136, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ13-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ13" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBE7-1", "uniprot_ac": "Q3ZBE7", "uniprot_id": "YPEL5_BOVIN", "mass": { "chemical_mass": 13842.0, "monoisotopic_mass": 13842.0 }, "refseq": { "ac": "NP_001073261", "name": "protein yippee-like 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073261" }, "gene_names": [ { "name": "YPEL5", "type": "recommended", "evidence": [ { "id": "Q3ZBE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7" } ] }, { "name": "YPEL5", "type": "synonym", "evidence": [ { "id": "NP_001073261", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073261" } ] } ], "protein_names": [ { "name": "Protein yippee-like 5", "type": "recommended", "evidence": [ { "id": "Q3ZBE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7/entry#names_and_taxonomy" } ] }, { "name": "protein yippee-like 5", "type": "synonym", "evidence": [ { "id": "NP_001073261", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073261" } ] } ], "function": [ { "annotation": "Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for normal cell proliferation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7#function" }, { "database": "UniProtKB", "id": "P62699", "url": "https://www.uniprot.org/uniprotkb/P62699#function" }, { "database": "UniProtKB", "id": "Q65Z55", "url": "https://www.uniprot.org/uniprotkb/Q65Z55#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "YPEL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7", "locus": { "chromosome": "11", "start_pos": 69713717, "end_pos": 69727353, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023744", "url": "https://www.ensembl.org/id/ENSBTAG00000023744" } ] } } ], "crossref": [ { "id": "Q3ZBE7", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBE7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023744", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023744", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "780856", "url": "https://www.ncbi.nlm.nih.gov/gene/780856", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:780856", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:780856", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YNCAACE", "url": "https://omabrowser.org/oma/group/YNCAACE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBE7", "url": "https://www.orthodb.org/?gene=Q3ZBE7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13848", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13848", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001073261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073261", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SLG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBE7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBE7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRIFLDHIGGTRLFSCANCDTILTNRSELISTRFTGATGRAFLFNKVVNLQYSEVQDRVMLTGRHMVRDVSCKNCNSKLGWIYEFATEDSQRYKEGRVILERALVRESEGFEEHVPSDNS", "length": 121, "header": "sp|Q3ZBE7-1|YPEL5_BOVIN Isoform 1 of Protein yippee-like 5 OS=Bos taurus OX=9913 GN=YPEL5 PE=2 SV=1 CANONICAL=Q3ZBE7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLG7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7/entry#A0AAA9SLG7-1", "sequence": { "sequence": "RHGVAVLQKGHILSRLALATGGVAVVAFVCCPAKAGCPPPCPPAPQETPDRGRGPRPLDWRAWRDCWAAVGRPGPRGGPLSCFRPLFVVREEAGPGRAALGPRLLPIGPRRHVPAISWGQPGLRGLGGCGCSHPAPGSPAVPTASCILPLLVGRAVFRASAIKMGRIFLDHIGGTRLFSCANCDTILTNRSELISTRFTGATGRAFLFNKVVNLQYSEVQDRVMLTGRHMVRDVSCKNCNSKLGWIYEFATEDSQRYKEGRVILERALVRESEGFEEHVPSDNS", "length": 284, "header": "tr|A0AAA9SLG7-1|YPEL5_BOVIN Computationally mapped isoform of Protein yippee-like 5 OS=Bos taurus OX=9913 GN=YPEL5 PE=2 SV=1 CANONICAL=Q3ZBE7-1" }, "locus": { "chromosome": "11", "start_pos": 69726709, "end_pos": 69714436, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113028.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113028.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084760.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084760.1" } ] } }, { "isoform_ac": "Q3ZBE7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7/entry#Q3ZBE7-1", "sequence": { "sequence": "MGRIFLDHIGGTRLFSCANCDTILTNRSELISTRFTGATGRAFLFNKVVNLQYSEVQDRVMLTGRHMVRDVSCKNCNSKLGWIYEFATEDSQRYKEGRVILERALVRESEGFEEHVPSDNS", "length": 121, "header": "sp|Q3ZBE7-1|YPEL5_BOVIN Isoform 1 of Protein yippee-like 5 OS=Bos taurus OX=9913 GN=YPEL5 PE=2 SV=1 CANONICAL=Q3ZBE7-1" }, "locus": { "chromosome": "11", "start_pos": 69716274, "end_pos": 69714436, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032525.2", "url": "https://www.ensembl.org/id/ENSBTAT00000032525.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032456.1", "url": "https://www.ensembl.org/id/ENSBTAP00000032456.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 118, "end_pos": 118, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7" } ], "site_lbl": "Ser118" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:780856", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:780856", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1TCI2-1", "protein_name": "Protein yippee-like", "gene_name": "YPEL5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGRIFLDHIGGTRLFSCANCDTILTNRSELISTRFTGATGRAFLFNKVVNLQYSEVQDRVMLTGRHMVRDVSCKNCNSKLGWIYEFATEDSQRYKEGRVILERALVRESEGFEEHVPSDNS", "length": 121 }, "evidence": [ { "id": "Q3ZBE7", "url": "https://omabrowser.org/oma/group/Q3ZBE7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7JVK3-1", "protein_name": "Protein yippee-like", "gene_name": "Ypel5", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGRIFLDHIGGTRLFSCANCDTILTNRSELISTRFTGATGRAFLFNKVVNLQYSEVQDRVMLTGRHMVRDVSCKNCNSKLGWIYEFATEDSQRYKEGRVILERALVRESEGFEEHVPSDNS", "length": 121 }, "evidence": [ { "id": "Q3ZBE7", "url": "https://omabrowser.org/oma/group/Q3ZBE7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D4A4Q3-1", "protein_name": "Protein yippee-like", "gene_name": "Ypel5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGRIFLDHIGGTRLFSCANCDTILTNRSELISTRFTGATGRAFLFNKVVNLQYSEVQDRVMLTGRHMVRDVSCKNCNSKLGWIYEFATEDSQRYKEGRVILERALVRESEGFEEHVPSDNS", "length": 121 }, "evidence": [ { "id": "Q3ZBE7", "url": "https://omabrowser.org/oma/group/Q3ZBE7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F8W4R5-1", "protein_name": "Protein yippee-like", "gene_name": "ypel5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGRIFLDHIGGTRLFSCANCDTILTNRSELISTRFTGATGRAFLFNKVVNLQYSEVQDRVMLTGRHMVRDVSCKNCNSKLGWIYEFATEDSQRYKEGRVILERALVRESEGFEEHVPSDAS", "length": 121 }, "evidence": [ { "id": "Q3ZBE7", "url": "https://omabrowser.org/oma/group/Q3ZBE7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P62699-1", "protein_name": "Protein yippee-like 5", "gene_name": "YPEL5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGRIFLDHIGGTRLFSCANCDTILTNRSELISTRFTGATGRAFLFNKVVNLQYSEVQDRVMLTGRHMVRDVSCKNCNSKLGWIYEFATEDSQRYKEGRVILERALVRESEGFEEHVPSDNS", "length": 121 }, "evidence": [ { "id": "Q3ZBE7", "url": "https://omabrowser.org/oma/group/Q3ZBE7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P62700-1", "protein_name": "Protein yippee-like 5", "gene_name": "Ypel5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGRIFLDHIGGTRLFSCANCDTILTNRSELISTRFTGATGRAFLFNKVVNLQYSEVQDRVMLTGRHMVRDVSCKNCNSKLGWIYEFATEDSQRYKEGRVILERALVRESEGFEEHVPSDNS", "length": 121 }, "evidence": [ { "id": "Q3ZBE7", "url": "https://omabrowser.org/oma/group/Q3ZBE7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9XZF0-1", "protein_name": "Protein yippee", "gene_name": "Ype", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGRIFLEHLGGLKLFNCAQCHTNLTNRSQLISTRFTGATGRAYLFKRVVNLTFSNIQERVMLTGRHMVRDVMCKNCGAKLGWMYEFATEESQKYKEGRVILEYALITEAEGFPSEAATTSH", "length": 121 }, "evidence": [ { "id": "Q3ZBE7", "url": "https://omabrowser.org/oma/group/Q3ZBE7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7" } ], "pmid": "" }, { "name": "ubiquitin ligase complex", "id": "GO:0000151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000151", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7" } ], "pmid": "" }, { "name": "mitotic spindle pole", "id": "GO:0097431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097431", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell population proliferation", "id": "GO:0008283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008283", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 26, "end_pos": 28, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBE7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 121, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBE7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBE7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZBE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7" }, { "id": "PRU01128", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01128" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Yippee", "eco_id": "ECO_0000255", "start_pos": 13, "end_pos": 110, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "Q3ZBE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7#function" }, { "id": "Q3ZBE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7" }, { "id": "PRU01128", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01128" } ], "binding_site_uniprot": 17, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 17, "end_pos": 17, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3ZBE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7#function" }, { "id": "Q3ZBE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7" }, { "id": "PRU01128", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01128" } ], "binding_site_uniprot": 20, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 20, "end_pos": 20, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3ZBE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7#function" }, { "id": "Q3ZBE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7" }, { "id": "PRU01128", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01128" } ], "binding_site_uniprot": 73, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 73, "end_pos": 73, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3ZBE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7#function" }, { "id": "Q3ZBE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE7" }, { "id": "PRU01128", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01128" } ], "binding_site_uniprot": 76, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 76, "end_pos": 76, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 118 ], "sequon_annotation_sites": [ { "start_pos": 26, "end_pos": 28 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0A9-1", "uniprot_ac": "Q3T0A9", "uniprot_id": "SHSA5_BOVIN", "mass": { "chemical_mass": 23224.0, "monoisotopic_mass": 23224.0 }, "refseq": { "ac": "NP_001030563", "name": "protein shisa-5 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030563" }, "gene_names": [ 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"categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8957275", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030563", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SMZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMV1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRV4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U2Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2Q1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U2Q1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2Q1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZT45", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZT45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZT45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZT45-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFP6", "url": "https://www.uniprot.org/uniprotkb/F1MFP6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFP6-1", "url": "https://www.uniprot.org/uniprotkb/F1MFP6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0A9", "url": "https://www.uniprot.org/uniprotkb/Q3T0A9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0A9-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0A9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPAPAPRILVLLLLLLPAPEGAQSELCMISHGRKVDPWVCPDFCCGNCNDQYCCSDVLKQVMWIEEDCHAPEASILTDDFDSGFDSDPVARFGTVIAIGVTLFVIAVVTVIVCCTCSCCCLYKMCRRPQPVVTTTMATTVTHTPYLQPPSYPGPTYQGYHSVVPQPGMPTAPYPTQPTGPPAYHETMAGGAALPYPASQPPYNPAYMEPPKAVP", "length": 216, "header": "sp|Q3T0A9-1|SHSA5_BOVIN Isoform 1 of Protein shisa-5 OS=Bos taurus OX=9913 GN=SHISA5 PE=2 SV=1 CANONICAL=Q3T0A9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMZ8-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0A9/entry#A0AAA9SMZ8-1", "sequence": { "sequence": "MPQPGECWGSEGGVSANHREDCGCCQPIPWAQSELCMISHGRKVDPWVCPDFCCGNCNDQYCCSDVLKQVMWIEEDCHAPEASILTDDFDSGFDSDPVARFGTVIAIGVTLFVIAVVTVIVCCTCSCCCLYKMCRRPQPVVTTTMATTVTHTPYLQPPSYPGPTYQGYHSVVPQPGMPTAPYPTQPTGPPAYHETMAGGAALPYPASQPPYNPAYMEPPKAVP", "length": 223, "header": "tr|A0AAA9SMZ8-1|SHSA5_BOVIN Computationally mapped isoform of Protein shisa-5 OS=Bos taurus OX=9913 GN=SHISA5 PE=2 SV=1 CANONICAL=Q3T0A9-1" }, "locus": { "chromosome": "22", "start_pos": 51398148, "end_pos": 51369521, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102809.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102809.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086688.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086688.1" } ] } }, { "isoform_ac": "A0AAA9TMV1-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0A9/entry#A0AAA9TMV1-1", "sequence": { "sequence": "MNPRRWRPGWGTFKAQSELCMISHGRKVDPWVCPDFCCGNCNDQYCCSDVLKQVMWIEEDCHAPEASILTDDFDSGFDSDPVARFGTVIAIGVTLFVIAVVTVIVCCTCSCCCLYKMCRRPQPVVTTTMATTVTHTPYLQPPSYPGPTYQGYHSVVPQPGMPTAPYPTQPTGPPAYHETMAGGAALPYPASQPPYNPAYMEPPKAVP", "length": 207, "header": "tr|A0AAA9TMV1-1|SHSA5_BOVIN Computationally mapped isoform of Protein shisa-5 OS=Bos taurus OX=9913 GN=SHISA5 PE=2 SV=1 CANONICAL=Q3T0A9-1" }, "locus": { "chromosome": "22", "start_pos": 51398148, "end_pos": 51372397, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123036.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123036.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098570.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098570.1" } ] } }, { "isoform_ac": "A0AAA9TRV4-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0A9/entry#A0AAA9TRV4-1", "sequence": { "sequence": "MQRARRHMEPQSLQELKSGLCLKSCGLPTWLSAQSELCMISHGRKVDPWVCPDFCCGNCNDQYCCSDVLKQVMWIEEDCHAPEASILTDDFDSGFDSDPVARFGTVIAIGVTLFVIAVVTVIVCCTCSCCCLYKMCRRPQPVVTTTMATTVTHTPYLQPPSYPGPTYQGYHSVVPQPGMPTAPYPTQPTGPPAYHETMAGGAALPYPASQPPYNPAYMEPPKAVP", "length": 225, "header": "tr|A0AAA9TRV4-1|SHSA5_BOVIN Computationally mapped isoform of Protein shisa-5 OS=Bos taurus OX=9913 GN=SHISA5 PE=2 SV=1 CANONICAL=Q3T0A9-1" }, "locus": { "chromosome": "22", "start_pos": 51398148, "end_pos": 51369934, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131626.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131626.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101319.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101319.1" } ] } }, { "isoform_ac": "A0AAA9U2Q1-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0A9/entry#A0AAA9U2Q1-1", "sequence": { "sequence": "MGFGTVIAIGVTLFVIAVVTVIVCCTCSCCCLYKMCRRPQPVVTTTMATTVTHTPYLQPPSYPGPTYQGYHSVVPQPGMPTAPYPTQPTGPPAYHETMAGGAALPYPASQPPYNPAYMEPPKAVP", "length": 125, "header": "tr|A0AAA9U2Q1-1|SHSA5_BOVIN Computationally mapped isoform of Protein shisa-5 OS=Bos taurus OX=9913 GN=SHISA5 PE=2 SV=1 CANONICAL=Q3T0A9-1" }, "locus": { "chromosome": "22", "start_pos": 51398148, "end_pos": 51396103, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113743.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113743.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103905.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103905.1" } ] } }, { "isoform_ac": "A0AAF6ZT45-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0A9/entry#A0AAF6ZT45-1", "sequence": { "sequence": "MVLRLHMVPAQSELCMISHGRKVDPWVCPDFCCGNCNDQYCCSDVLKQVMWIEEDCHAPEASILTDDFDSGFDSDPVARFGTVIAIGVTLFVIAVVTVIVCCTCSCCCLYKMCRRPQPVVTTTMATTVTHTPYLQPPSYPGPTYQGYHSVVPQPGMPTAPYPTQPTGPPAYHETMAGGAALPYPASQPPYNPAYMEPPKAVP", "length": 202, "header": "tr|A0AAF6ZT45-1|SHSA5_BOVIN Computationally mapped isoform of Protein shisa-5 OS=Bos taurus OX=9913 GN=SHISA5 PE=2 SV=1 CANONICAL=Q3T0A9-1" }, "locus": { "chromosome": "22", "start_pos": 51398148, "end_pos": 51374501, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078796.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078796.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057127.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057127.2" } ] } }, { "isoform_ac": "F1MFP6-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0A9/entry#F1MFP6-1", "sequence": { "sequence": "MAAPAPAPRILVLLLLLLPAPEGAQSELCMISHGRKVDPWVCPDFCCGNCNDQYCCSDVLKQVMWIEEDCHAPEARFGTVIAIGVTLFVIAVVTVIVCCTCSCCCLYKMCRRPQPVVTTTMATTVTHTPYLQPPSYPGPTYQGYHSVVPQPGMPTAPYPTQPTGPPAYHETMAGGAALPYPASQPPYNPAYMEPPKAVP", "length": 199, "header": "tr|F1MFP6-1|SHSA5_BOVIN Computationally mapped isoform of Protein shisa-5 OS=Bos taurus OX=9913 GN=SHISA5 PE=2 SV=3 CANONICAL=Q3T0A9-1" }, "locus": { "chromosome": "22", "start_pos": 51398148, "end_pos": 51371820, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012101.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012101.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012101.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012101.6" } ] } }, { "isoform_ac": "Q3T0A9-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0A9/entry#Q3T0A9-1", "sequence": { "sequence": "MAAPAPAPRILVLLLLLLPAPEGAQSELCMISHGRKVDPWVCPDFCCGNCNDQYCCSDVLKQVMWIEEDCHAPEASILTDDFDSGFDSDPVARFGTVIAIGVTLFVIAVVTVIVCCTCSCCCLYKMCRRPQPVVTTTMATTVTHTPYLQPPSYPGPTYQGYHSVVPQPGMPTAPYPTQPTGPPAYHETMAGGAALPYPASQPPYNPAYMEPPKAVP", "length": 216, "header": "sp|Q3T0A9-1|SHSA5_BOVIN Isoform 1 of Protein shisa-5 OS=Bos taurus OX=9913 GN=SHISA5 PE=2 SV=1 CANONICAL=Q3T0A9-1" }, "locus": { "chromosome": "22", "start_pos": 51398148, "end_pos": 51371820, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098388.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098388.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102046.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102046.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 177, "start_aa": "Thr", "end_pos": 177, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr177", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616861", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616861", "resource": "KEGG Pathway" }, { "id": "R-BTA-381426", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "resource": "Reactome", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" }, { "id": "R-BTA-8957275", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "resource": "Reactome", "description": "Post-translational protein phosphorylation" } ], "orthologs": [ { "uniprot_canonical_ac": "Q1LXB2-1", "protein_name": "Protein shisa-5", "gene_name": "shisa10.1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MASTVPVLLLLFAGLFTATLADDDCKPYITSSGKMRTSIDCGFLQFCCGNCDNRYCCSNPLSKLTEDQQDDCFFSNDFNKPIVVGVTITGIVLLIIVFIVCCVCPCCCIYKMCRKPRPVMGATTTTVVSTQCIQQPVVQGGQYPPYQPIPPQSGYSGAPGYGATPMPKAPYQGHPYAAGPPPPYQEAGGPGYPVPYSQAAFDGGQASYPMQPPAQPGYGQPGYGQPAYGQPGYPQQHPPTDYSATQPAYNPAYVEPPKPGY", "length": 261 }, "evidence": [ { "id": "Q3T0A9", "url": "https://omabrowser.org/oma/group/Q3T0A9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5XIH2-1", "protein_name": "Protein shisa-5", "gene_name": "Shisa5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGFGATVAIGLTVFVVFIATIIVCFTCSCCCLYKMCCRPRPVVSNTTTTTVVHTAYPQPQPVAPSYPGPTYQGYHPMPPQPGMPAAPYPTQYPPPYLAQSTGPPAYHETLAGASQPPYNPAYMDPPKAVP", "length": 130 }, "evidence": [ { "id": "Q3T0A9", "url": "https://omabrowser.org/oma/group/Q3T0A9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8N114-1", "protein_name": "Protein shisa-5", "gene_name": "SHISA5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTAPVPAPRILLPLLLLLLLTPPPGARGEVCMASRGLSLFPESCPDFCCGTCDDQYCCSDVLKKFVWSEERCAVPEASVPASVEPVEQLGSALRFRPGYNDPMSGFGATLAVGLTIFVLSVVTIIICFTCSCCCLYKTCRRPRPVVTTTTSTTVVHAPYPQPPSVPPSYPGPSYQGYHTMPPQPGMPAAPYPMQYPPPYPAQPMGPPAYHETLAGGAAAPYPASQPPYNPAYMDAPKAAL", "length": 240 }, "evidence": [ { "id": "Q3T0A9", "url": "https://omabrowser.org/oma/group/Q3T0A9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A9", "url": "https://www.uniprot.org/uniprotkb/Q3T0A9" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A9", "url": "https://www.uniprot.org/uniprotkb/Q3T0A9" } ], "pmid": "" }, { "name": 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"id": "Q3T0A9", "url": "https://www.uniprot.org/uniprotkb/Q3T0A9" } ], "pmid": "" }, { "name": "regulation of COPII vesicle uncoating", "id": "GO:0090111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090111", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A9", "url": "https://www.uniprot.org/uniprotkb/Q3T0A9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "molecular condensate scaffold activity", "id": "GO:0140693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140693", "evidence": [ { "database": "UniProtKB", "id": "Q3T0A9", "url": "https://www.uniprot.org/uniprotkb/Q3T0A9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0A9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 216, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0A9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0A9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 177 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBH5-1", "uniprot_ac": "Q2TBH5", "uniprot_id": "UBXN8_BOVIN", "mass": { "chemical_mass": 31335.0, "monoisotopic_mass": 31335.0 }, "refseq": { "ac": "NP_001033761", "name": "UBX domain-containing protein 8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033761" }, "gene_names": [ { "name": "UBXN8", "type": "recommended", "evidence": [ { "id": "Q2TBH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH5" } ] }, { "name": "UBXD6", "type": "synonym", "evidence": [ { "id": "NP_001033761", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033761" }, { "id": "Q2TBH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH5" } ] }, { "name": "UBXN8", "type": "synonym", "evidence": [ { "id": "NP_001033761", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033761" } ] } ], "protein_names": [ { "name": "UBX domain-containing protein 8", "type": "recommended", "evidence": [ { "id": "Q2TBH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH5/entry#names_and_taxonomy" } ] }, { "name": "UBX domain containing 6", "type": "synonym", "evidence": [ { "id": "NP_001033761", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033761" } ] }, { "name": "UBX domain-containing protein 6", "type": "synonym", "evidence": [ { "id": "NP_001033761", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033761" }, { "id": "Q2TBH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH5/entry#names_and_taxonomy" } ] }, { "name": "UBX domain-containing protein 8", "type": "synonym", "evidence": [ { "id": "NP_001033761", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033761" } ] } ], "function": [ { "annotation": "Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AES4", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AES4#function" }, { "database": "UniProtKB", "id": "ARBA00056107", "url": "https://www.uniprot.org/uniprotkb/ARBA00056107#function" }, { "database": "UniProtKB", "id": "Q2TBH5", "url": "https://www.uniprot.org/uniprotkb/Q2TBH5#function" }, { "database": "UniProtKB", "id": "A0AAA9SPX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPX7#function" } ] }, { "annotation": "May play a role in reproduction.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH5", "url": "https://www.uniprot.org/uniprotkb/Q2TBH5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBH5", "url": "https://www.uniprot.org/uniprotkb/Q2TBH5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBXN8", "url": "https://www.uniprot.org/uniprotkb/Q2TBH5", "locus": { "chromosome": "27", "start_pos": 26885073, "end_pos": 26867669, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004173", "url": "https://www.ensembl.org/id/ENSBTAG00000004173" } ] } } ], "crossref": [ { "id": "Q2TBH5", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBH5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004173", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004173", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01774", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01774", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509646", "url": "https://www.ncbi.nlm.nih.gov/gene/509646", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050730", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050730", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509646", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509646", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MMKTGYH", "url": "https://omabrowser.org/oma/group/MMKTGYH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBH5", "url": "https://www.orthodb.org/?gene=Q2TBH5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23322", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23322", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23322:SF93", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23322:SF93", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00789", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00789", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033761", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SPX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPX7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AES4", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AES4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AES4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AES4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBH5", "url": "https://www.uniprot.org/uniprotkb/Q2TBH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBH5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASRGVVGIFLLSALPLLCLELRRGKPDLGIKDLILLCGRIFLLLALLTLIISVTTSWVNSFKPSQVYLKEEEEKNEKRQKLVRKKQQEAQGEKVSRYIENVLKPSQEMKLKKLEERFYQMTGETWKLSNGHKLGGDEDLELDSESQTSFETSNREAAKRRNLPNSVTNISPPAEQPTKKEVLDLPEEPPETAEEVVTVALRCPSGRVLRRRFFKSCSSQVLFDWMMKLGYRTSLYSLSTSFPRRPLEVEAGWSLQDIGITVDTVLNVEEKEQSS", "length": 275, "header": "sp|Q2TBH5-1|UBXN8_BOVIN Isoform 1 of UBX domain-containing protein 8 OS=Bos taurus OX=9913 GN=UBXN8 PE=2 SV=1 CANONICAL=Q2TBH5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPX7-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH5/entry#A0AAA9SPX7-1", "sequence": { "sequence": "MASRGVVGIFLLSALPLLCLELRRGKPDLGIKDLILLCGRIFLLLALLTLIISVTTSWVNSFKPSQVYLKEEEEKNEKRQKLVRKKQQEAQGEKGDEDLELDSESQTSFETSNREAAKRRNLPNSVTNISPPAEQPTKKEVLDLPEEPPETAEEVVTVALRCPSGRVLRRRFFKSCSSQVLFDWMMKLGYRTSLYSLSTSFPRRPLEVEAGWSLQDIGITVDTVLNVEEKEQSS", "length": 234, "header": "tr|A0AAA9SPX7-1|UBXN8_BOVIN Computationally mapped isoform of UBX domain-containing protein 8 OS=Bos taurus OX=9913 GN=UBXN8 PE=2 SV=1 CANONICAL=Q2TBH5-1" }, "locus": { "chromosome": "27", "start_pos": 26884651, "end_pos": 26867694, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109339.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109339.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088354.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088354.1" } ] } }, { "isoform_ac": "A0AAF7AES4-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH5/entry#A0AAF7AES4-1", "sequence": { "sequence": "NVLNCNYLILLCGRIFLLLALLTLIISVTTSWVNSFKPSQVYLKEEEEKNEKRQKLVRKKQQEAQGEKVSRYIENVLKPSQEMKLKKLEERFYQMTGETWKLSNGHKLGGDEDLELDSESQTSFETSNREAAKRRNLPNSVTNISPPAEQPTKKEVLDLPEEPPETAEEVVTVALRCPSGRVLRRRFFKSCSSQVLFDWMMKLGYRTSLYSLSTSFPRRPLEVEAGWSLQDIGITVDTVLNVEEKEQSS", "length": 249, "header": "tr|A0AAF7AES4-1|UBXN8_BOVIN Computationally mapped isoform of UBX domain-containing protein 8 OS=Bos taurus OX=9913 GN=UBXN8 PE=2 SV=1 CANONICAL=Q2TBH5-1" }, "locus": { "chromosome": "27", "start_pos": 26884651, "end_pos": 26872117, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076763.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076763.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067731.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067731.2" } ] } }, { "isoform_ac": "Q2TBH5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBH5/entry#Q2TBH5-1", "sequence": { "sequence": "MASRGVVGIFLLSALPLLCLELRRGKPDLGIKDLILLCGRIFLLLALLTLIISVTTSWVNSFKPSQVYLKEEEEKNEKRQKLVRKKQQEAQGEKVSRYIENVLKPSQEMKLKKLEERFYQMTGETWKLSNGHKLGGDEDLELDSESQTSFETSNREAAKRRNLPNSVTNISPPAEQPTKKEVLDLPEEPPETAEEVVTVALRCPSGRVLRRRFFKSCSSQVLFDWMMKLGYRTSLYSLSTSFPRRPLEVEAGWSLQDIGITVDTVLNVEEKEQSS", "length": 275, "header": "sp|Q2TBH5-1|UBXN8_BOVIN Isoform 1 of UBX domain-containing protein 8 OS=Bos taurus OX=9913 GN=UBXN8 PE=2 SV=1 CANONICAL=Q2TBH5-1" }, "locus": { "chromosome": "27", "start_pos": 26884651, "end_pos": 26867694, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005462.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005462.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005462.3", "url": "https://www.ensembl.org/id/ENSBTAP00000005462.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509646", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509646", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RX67-1", "protein_name": "UBX domain protein 8", "gene_name": "UBXN8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVSLGVVGIFLLSALPLLCLELRRGVPDLGIKDLILLCGRIFLLLALLTLIISVATSWINSFKSTQVYLKEEEEEKNEKKQKLVRKKQQEAQGEKASRYIENVLKPYQEMKLKRLEERFYQMTGETWKLSNGHKLGGDEDLVLESESHTSSETSNREAAKRRNLPKLLTRVSPPAAQPTQKKVLDLPEEPPETAEEVVTVALRCPSGRVLRRRFFKSCSSQVLFDWMMKIGYHPSLYSLATSFPRRLLEVEEGWSLQDLGITVDTILNVEEKEQSS", "length": 276 }, "evidence": [ { "id": "Q2TBH5", "url": "https://omabrowser.org/oma/group/Q2TBH5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H608-1", "protein_name": "UBX domain-containing protein 8 isoform X1", "gene_name": "Ubxn8", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASRGVVGLFLLSALPLLCLELRRGIPSLGIKDLILLSGRIFLLLALLTLVISVATSWFNSCKPSRVHLTEGEEENEKRQRLVRKKQQEAQGEQASRYIQNVLKPQQEMKLKKLEERFYQMTGETWKLTTGHKLEGDEDLVLDSSSQVSLETANREAARRRNLPKLLTEISPPAPQPTKKEVPNLPEEPPETAEEVVTVALRCPSGSVLRRRFFKSWNSQVLLDWMMKIGYHKSIYSLSTSFPRRPLETEGGLSLEDIGITVDTVLNVEEKEQSGQ", "length": 276 }, "evidence": [ { "id": "Q2TBH5", "url": "https://omabrowser.org/oma/group/Q2TBH5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O00124-1", "protein_name": "UBX domain-containing protein 8", "gene_name": "UBXN8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASRGVVGIFFLSAVPLVCLELRRGIPDIGIKDFLLLCGRILLLLALLTLIISVTTSWLNSFKSPQVYLKEEEEKNEKRQKLVRKKQQEAQGEKASRYIENVLKPHQEMKLRKLEERFYQMTGEAWKLSSGHKLGGDEGTSQTSFETSNREAAKSQNLPKPLTEFPSPAEQPTCKEIPDLPEEPSQTAEEVVTVALRCPSGNVLRRRFLKSYSSQVLFDWMTRIGYHISLYSLSTSFPRRPLAVEGGQSLEDIGITVDTVLILEEKEQTN", "length": 270 }, "evidence": [ { "id": "Q2TBH5", "url": "https://omabrowser.org/oma/group/Q2TBH5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH5", "url": "https://www.uniprot.org/uniprotkb/Q2TBH5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ERAD pathway", "id": "GO:0036503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH5", "url": "https://www.uniprot.org/uniprotkb/Q2TBH5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin binding", "id": "GO:0043130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130", "evidence": [ { "database": "UniProtKB", "id": "Q2TBH5", "url": "https://www.uniprot.org/uniprotkb/Q2TBH5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 169, "end_pos": 171, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBH5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 275, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBH5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBH5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2TBH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH5" }, { "id": "PRU00215", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00215" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBX", "eco_id": "ECO_0000255", "start_pos": 192, "end_pos": 268, "start_aa": "Thr", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 169, "end_pos": 171 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T181-1", "uniprot_ac": "Q3T181", "uniprot_id": "LT4R1_BOVIN", "mass": { "chemical_mass": 37689.0, "monoisotopic_mass": 37689.0 }, "refseq": { "ac": "NP_001029910", "name": "leukotriene B4 receptor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029910" }, "gene_names": [ { "name": "LTB4R", "type": "recommended", "evidence": [ { "id": "Q3T181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T181" } ] }, { "name": "LTB4R", "type": "synonym", "evidence": [ { "id": "NP_001029910", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029910" } ] } ], "protein_names": [ { "name": "Leukotriene B4 receptor 1", "type": "recommended", "evidence": [ { "id": "Q3T181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T181/entry#names_and_taxonomy" } ] }, { "name": "LTB4-R 1", "type": "synonym", "evidence": [ { "id": "NP_001029910", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029910" }, { "id": "Q3T181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T181/entry#names_and_taxonomy" } ] }, { "name": "LTB4-R1", "type": "synonym", "evidence": [ { "id": "NP_001029910", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029910" }, { "id": "Q3T181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T181/entry#names_and_taxonomy" } ] }, { "name": "leukotriene B4 receptor 1", "type": "synonym", "evidence": [ { "id": "NP_001029910", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029910" } ] } ], "function": [ { "annotation": "In luteal-phase endometrium, expression of 5-LO (5-lipoxygenase) and LTB4R (leukotriene B4 receptor) is highest on Days 2-4; expression of LTCS (leukotriene-C4 synthase) and CysLTR2 (cysteinyl leukotriene receptor 2) is highest on Days 16-18. In luteal-phase endometrium, LTB4 level is highest on Days 2-4; LTC4 level is highest on Days 16-18. Studies were conducted in Poland on Holstein Polish Black and White dairy cows.", "evidence": [ { "database": "RefSeq", "id": "NP_001029910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029910" }, { "database": "PubMed", "id": "25483008", "url": "https://glygen.org/publication/PubMed/25483008" } ] }, { "annotation": "Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T181", "url": "https://www.uniprot.org/uniprotkb/Q3T181#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T181", "url": "https://www.uniprot.org/uniprotkb/Q3T181" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LTB4R", "url": "https://www.uniprot.org/uniprotkb/Q3T181", "locus": { "chromosome": "10", "start_pos": 20853775, "end_pos": 20856625, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010238", "url": "https://www.ensembl.org/id/ENSBTAG00000010238" } ] } } ], "crossref": [ { "id": "Q3T181", "url": "https://alphafold.ebi.ac.uk/entry/Q3T181", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010238", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010238", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613482", "url": "https://www.ncbi.nlm.nih.gov/gene/613482", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000826", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000826", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003981", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003981", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613482", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613482", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LCHYICG", "url": "https://omabrowser.org/oma/group/LCHYICG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T181", "url": "https://www.orthodb.org/?gene=Q3T181", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24225", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24225", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24225:SF72", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24225:SF72", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-391906", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-391906", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029910", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SR24", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR24-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T181", "url": "https://www.uniprot.org/uniprotkb/Q3T181", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T181-1", "url": "https://www.uniprot.org/uniprotkb/Q3T181-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNTTSPAAPSSSGVSFISLLVIIVLSVALAVGLPGNSFVVWSILAKLRKRSVTALMVLHLALADLAVLLTAPFFLYSVAQGTWTFGLSSCRLFHYVCGVSMYASVLLIMTMSLDRSLAVALPFVSQKLRTKAVAWRVLAGIWVMSVLLATPVLLYRTVHLGLNNRSLTCFLKYPSERHRAFHLFFEVITGFLLPFLVVVASYCDIGRRLRARRFRRSRRTGRLVALIILAFAAFWLPYHVVNLAEGFRAAAGKALGSGPVGRRLLLARHVLITLAFLSSSVNPLLYACAGGGLLRSAGVGFIAKLLEGTGSETSSSRRKGTLAQTLRGTPASPEPDPAESLTASTNPLE", "length": 349, "header": "sp|Q3T181-1|LT4R1_BOVIN Isoform 1 of Leukotriene B4 receptor 1 OS=Bos taurus OX=9913 GN=LTB4R PE=2 SV=1 CANONICAL=Q3T181-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SR24-1", "url": "https://www.uniprot.org/uniprotkb/Q3T181/entry#A0AAA9SR24-1", "sequence": { "sequence": "MIRVVYPGEQHLMVLTLKTDESTQTRCIGSVRKPFLHVRVTLTLQVLAIAMNTTSPAAPSSSGVSFISLLVIIVLSVALAVGLPGNSFVVWSILAKLRKRSVTALMVLHLALADLAVLLTAPFFLYSVAQGTWTFGLSSCRLFHYVCGVSMYASVLLIMTMSLDRSLAVALPFVSQKLRTKAVAWRVLAGIWVMSVLLATPVLLYRTVHLGLNNRSLTCFLKYPSERHRAFHLFFEVITGFLLPFLVVVASYCDIGRRLRARRFRRSRRTGRLVALIILAFAAFWLPYHVVNLAEGFRAAAGKALGSGPVGRRLLLARHVLITLAFLSSSVNPLLYACAGGGLLRSAGVGFIAKLLEGTGSETSSSRRKGTLAQTLRGTPASPEPDPAESLTASTNPLE", "length": 399, "header": "tr|A0AAA9SR24-1|LT4R1_BOVIN Computationally mapped isoform of Leukotriene B4 receptor 1 OS=Bos taurus OX=9913 GN=LTB4R PE=2 SV=1 CANONICAL=Q3T181-1" }, "locus": { "chromosome": "10", "start_pos": 20855204, "end_pos": 20854008, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091442.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091442.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085415.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085415.1" } ] } }, { "isoform_ac": "Q3T181-1", "url": "https://www.uniprot.org/uniprotkb/Q3T181/entry#Q3T181-1", "sequence": { "sequence": "MNTTSPAAPSSSGVSFISLLVIIVLSVALAVGLPGNSFVVWSILAKLRKRSVTALMVLHLALADLAVLLTAPFFLYSVAQGTWTFGLSSCRLFHYVCGVSMYASVLLIMTMSLDRSLAVALPFVSQKLRTKAVAWRVLAGIWVMSVLLATPVLLYRTVHLGLNNRSLTCFLKYPSERHRAFHLFFEVITGFLLPFLVVVASYCDIGRRLRARRFRRSRRTGRLVALIILAFAAFWLPYHVVNLAEGFRAAAGKALGSGPVGRRLLLARHVLITLAFLSSSVNPLLYACAGGGLLRSAGVGFIAKLLEGTGSETSSSRRKGTLAQTLRGTPASPEPDPAESLTASTNPLE", "length": 349, "header": "sp|Q3T181-1|LT4R1_BOVIN Isoform 1 of Leukotriene B4 receptor 1 OS=Bos taurus OX=9913 GN=LTB4R PE=2 SV=1 CANONICAL=Q3T181-1" }, "locus": { "chromosome": "10", "start_pos": 20855054, "end_pos": 20854008, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090518.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090518.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080141.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080141.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 164, "start_aa": "Asn", "end_pos": 164, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn164", "evidence": [ { "id": "Q3T181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T181#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 2, "start_aa": "Asn", "end_pos": 2, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn2", "evidence": [ { "id": "Q3T181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T181#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Leukotriene production profiles and actions in the bovine endometrium during the oestrous cycle.", "journal": "Reproduction, fertility, and development", "date": "2016-04", "authors": "Korzekwa Anna J, Milewski Robert, \u0141upicka Martyna, Skarzynski Dariusz J", "evidence": [ { "database": "RefSeq", "id": "NP_001029910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029910" } ], "reference": [ { "type": "PubMed", "id": "25483008", "url": "https://glygen.org/publication/PubMed/25483008" } ] } ], "pathway": [ { "id": "bta:613482", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613482", "resource": "KEGG Pathway" }, { "id": "R-BTA-391906", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-391906", "resource": "Reactome", "description": "Leukotriene receptors" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4FAM3-1", "protein_name": "Leukotriene B4 receptor", "gene_name": "LTB4R", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNTTSPAASSSPPVMFISLLAIIPLSVALAVGLPGNSFVVWSILAKMRKRSVTALLVLHLALADLAVLLTAPFFLHSVAQGNWTFGLAGCRLFHYICGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAVAWRVLAGIWVASVLLATPVIVYRKVILKQNNRSLVCLPMYPSEGHRAFHLFFEVITGFLLPFLAVVASYSDIGRRLRTRRFRRSRRMGRLVVLIILAFAAFWLPYHVVNLAEAVRALTGKASGAGAVGKGLWLARQVFITLAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGTLGQTVRGDVASPEPGPTESLTVSTNPLE", "length": 349 }, "evidence": [ { "id": "Q3T181", "url": "https://omabrowser.org/oma/group/Q3T181/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HDI4-1", "protein_name": "Leukotriene B4 receptor 1", "gene_name": "Ltb4r", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAPNITSPAAASSPGGMSLSLPIVLLSVALAVGLPGNSFVVWSILRRMQKRSVTALLVLNLALADLAVLLTAPFFLHFLAQGTWSFKVTGCRLCHYVCGVSMYASVLLITIMSLDRSLAVARPFVSQKVRTKRVALWVLASIWLVSFLLATPVIAYRTVKRNNRTLTLVCQPDYPSDGHRAFHLLFETITGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHLVNLVEAGRALAGWDQDDSAGKRLKLARYVLIALAFLSSSVNPVLYACAGGGLLRSAGFGFVVKLLEATASEVSSTRRGGTLCQTQKSIPACPEPGPTDSFMTSSNPS", "length": 348 }, "evidence": [ { "id": "Q3T181", "url": "https://omabrowser.org/oma/group/Q3T181/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O88855-1", "protein_name": "Leukotriene B4 receptor 1", "gene_name": "Ltb4r", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAANTTSPAAPSSPGGMSLSLLPIVLLSVALAVGLPGNSFVVWSILKRMQKRTVTALLVLNLALADLAVLLTAPFFLHFLARGTWSFREMGCRLCHYVCGISMYASVLLITIMSLDRSLAVARPFMSQKVRTKAFARWVLAGIWVVSFLLAIPVLVYRTVKWNNRTLICAPNYPNKEHKVFHLLFEAITGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHLVNLVEAGRTVAGWDKNSPAGQRLRLARYVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVVKLLEGTGSEVSSTRRGGTLVQTPKDTPACPEPGPTDSFMTSSTIPESSK", "length": 351 }, "evidence": [ { "id": "Q3T181", "url": "https://omabrowser.org/oma/group/Q3T181/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q15722-1", "protein_name": "Leukotriene B4 receptor 1", "gene_name": "LTB4R", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN", "length": 352 }, "evidence": [ { "id": "Q3T181", "url": "https://omabrowser.org/oma/group/Q3T181/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3T181", "url": "https://www.uniprot.org/uniprotkb/Q3T181" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "neuropeptide signaling pathway", "id": "GO:0007218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007218", "evidence": [ { "database": "UniProtKB", "id": "Q3T181", "url": "https://www.uniprot.org/uniprotkb/Q3T181" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "G protein-coupled peptide receptor activity", "id": "GO:0008528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008528", "evidence": [ { "database": "UniProtKB", "id": "Q3T181", "url": "https://www.uniprot.org/uniprotkb/Q3T181" } ], "pmid": "" }, { "name": "leukotriene B4 receptor activity", "id": "GO:0001632", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001632", "evidence": [ { "database": "UniProtKB", "id": "Q3T181", "url": "https://www.uniprot.org/uniprotkb/Q3T181" } ], "pmid": "" }, { "name": "leukotriene receptor activity", "id": "GO:0004974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004974", "evidence": [ { "database": "UniProtKB", "id": "Q3T181", "url": "https://www.uniprot.org/uniprotkb/Q3T181" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T181-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 349, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T181-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T181" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 2, 164 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 164, "end_pos": 166 }, { "start_pos": 2, "end_pos": 4 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q32PI9-1", "uniprot_ac": "Q32PI9", "uniprot_id": "MPZL1_BOVIN", "mass": { "chemical_mass": 29314.0, "monoisotopic_mass": 29314.0 }, "refseq": { "ac": "NP_001069626", "name": "myelin protein zero-like protein 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069626" }, "gene_names": [ { "name": "MPZL1", "type": "recommended", "evidence": [ { "id": "Q32PI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI9" } ] }, { "name": "MPZL1", "type": "synonym", "evidence": [ { "id": "NP_001069626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069626" } ] }, { "name": "PZR", "type": "synonym", "evidence": [ { "id": "NP_001069626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069626" } ] } ], "protein_names": [ { "name": "Myelin protein zero-like protein 1", "type": "recommended", "evidence": [ { "id": "Q32PI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI9/entry#names_and_taxonomy" } ] }, { "name": "myelin protein zero-like protein 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001069626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069626" } ] }, { "name": "myelin protein zero-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001069626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069626" } ] }, { "name": "zero-related protein", "type": "synonym", "evidence": [ { "id": "NP_001069626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069626" } ] } ], "function": [ { "annotation": "Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. May be involved in regulation of integrin-mediated cell motility (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32PI9", "url": "https://www.uniprot.org/uniprotkb/Q32PI9#function" } ] }, { "annotation": "Phosphorylation and localization of PZR in cultured endothelial cells is reported.", "evidence": [ { "database": "RefSeq", "id": "NP_001069626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069626" }, { "database": "PubMed", "id": "18568953", "url": "https://glygen.org/publication/PubMed/18568953" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PI9", "url": "https://www.uniprot.org/uniprotkb/Q32PI9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MPZL1", "url": "https://www.uniprot.org/uniprotkb/Q32PI9", "locus": { "chromosome": "3", "start_pos": 915375, "end_pos": 997233, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002823", "url": "https://www.ensembl.org/id/ENSBTAG00000002823" } ] } } ], "crossref": [ { "id": "Q32PI9", "url": "https://alphafold.ebi.ac.uk/entry/Q32PI9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002823", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002823", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05715", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05715", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539387", "url": "https://www.ncbi.nlm.nih.gov/gene/539387", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000920", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000920", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539387", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539387", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RDYTGCN", "url": "https://omabrowser.org/oma/group/RDYTGCN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32PI9", "url": "https://www.orthodb.org/?gene=Q32PI9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13869", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13869", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13869:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13869:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069626", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SSB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUV6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUV6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5W3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5W3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5W3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5W3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PI9", "url": "https://www.uniprot.org/uniprotkb/Q32PI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PI9-1", "url": "https://www.uniprot.org/uniprotkb/Q32PI9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPAGAGALIASPDRRRCLWSVLAAALGLLTYGVSALEVYTPKEIFVANGTQGKLTCKFKSTNTTGTLTSVSWSFQPEGTDTTVSFFHYSQGQVYAGNYPPFKDRVSWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKEILPAFPVWVVVGIVTAVVLGLTLLITMILAVIYRRRNSKRDYAGCNTSENVSPVKQVSRKSPSDTEGLVKSLPSGSHQGPVIYAQLDHSGGHHSDRINKSESVVYADIRKN", "length": 269, "header": "sp|Q32PI9-1|MPZL1_BOVIN Isoform 1 of Myelin protein zero-like protein 1 OS=Bos taurus OX=9913 GN=MPZL1 PE=2 SV=1 CANONICAL=Q32PI9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSB7-1", "url": "https://www.uniprot.org/uniprotkb/Q32PI9/entry#A0AAA9SSB7-1", "sequence": { "sequence": "MAAPAGAGALIASPDRRRCLWSVLAAALGLLTYGVSALEVYTPKEIFVANGTQGKLTCKFKSTNTTGTLTSVSWSFQPEGTDTTVSGPVIYAQLDHSGGHHSDRINKSESVVYADIRKN", "length": 119, "header": "tr|A0AAA9SSB7-1|MPZL1_BOVIN Computationally mapped isoform of Myelin protein zero-like protein 1 OS=Bos taurus OX=9913 GN=MPZL1 PE=2 SV=1 CANONICAL=Q32PI9-1" }, "locus": { "chromosome": "3", "start_pos": 997121, "end_pos": 917821, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114154.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114154.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087006.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087006.1" } ] } }, { "isoform_ac": "A0AAA9SUV6-1", "url": "https://www.uniprot.org/uniprotkb/Q32PI9/entry#A0AAA9SUV6-1", "sequence": { "sequence": "MAAPAGAGALIASPDRRRCLWSVLAAALGLLTYGVSALEVYTPKEIFVANGTQGKLTCKFKSTNTTGTLTSVSWSFQPEGTDTTVSFFHYSQGQVYAGNYPPFKDRVSWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKEILPAFPVWVVVGIVTAVVLGLTLLITMILAVIYRRRNSKRDYAGAQSYMRS", "length": 209, "header": "tr|A0AAA9SUV6-1|MPZL1_BOVIN Computationally mapped isoform of Myelin protein zero-like protein 1 OS=Bos taurus OX=9913 GN=MPZL1 PE=2 SV=1 CANONICAL=Q32PI9-1" }, "locus": { "chromosome": "3", "start_pos": 997121, "end_pos": 917898, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120648.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120648.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089126.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089126.1" } ] } }, { "isoform_ac": "A0AAA9T5W3-1", "url": "https://www.uniprot.org/uniprotkb/Q32PI9/entry#A0AAA9T5W3-1", "sequence": { "sequence": "MAAPAGAGALIASPDRRRCLWSVLAAALGLLTYGVSALEVYTPKEIFVANGTQGKLTCKFKSTNTTGTLTSVSWSFQPEGTDTTVSFFHYSQGQVYAGNYPPFKDRVSWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKEILPAFPVWVVVGIVTAVVLGLTLLITMILAVIYRRRNSKRDYAGCNTSENVSPVKQVSRKSPSDTEGLVKSLPSGSHQGTQVQSLVREDPTYHRVTKPLCHDY", "length": 261, "header": "tr|A0AAA9T5W3-1|MPZL1_BOVIN Computationally mapped isoform of Myelin protein zero-like protein 1 OS=Bos taurus OX=9913 GN=MPZL1 PE=2 SV=1 CANONICAL=Q32PI9-1" }, "locus": { "chromosome": "3", "start_pos": 997121, "end_pos": 921835, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110444.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110444.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094151.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094151.1" } ] } }, { "isoform_ac": "Q32PI9-1", "url": "https://www.uniprot.org/uniprotkb/Q32PI9/entry#Q32PI9-1", "sequence": { "sequence": "MAAPAGAGALIASPDRRRCLWSVLAAALGLLTYGVSALEVYTPKEIFVANGTQGKLTCKFKSTNTTGTLTSVSWSFQPEGTDTTVSFFHYSQGQVYAGNYPPFKDRVSWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKEILPAFPVWVVVGIVTAVVLGLTLLITMILAVIYRRRNSKRDYAGCNTSENVSPVKQVSRKSPSDTEGLVKSLPSGSHQGPVIYAQLDHSGGHHSDRINKSESVVYADIRKN", "length": 269, "header": "sp|Q32PI9-1|MPZL1_BOVIN Isoform 1 of Myelin protein zero-like protein 1 OS=Bos taurus OX=9913 GN=MPZL1 PE=2 SV=1 CANONICAL=Q32PI9-1" }, "locus": { "chromosome": "3", "start_pos": 997121, "end_pos": 917821, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003653.5", "url": "https://www.ensembl.org/id/ENSBTAT00000003653.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003653.4", "url": "https://www.ensembl.org/id/ENSBTAP00000003653.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 130, "start_aa": "Asn", "end_pos": 130, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn130", "evidence": [ { "id": "Q32PI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI9#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 50, "start_aa": "Asn", "end_pos": 50, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn50", "evidence": [ { "id": "Q32PI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI9#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 64, "start_aa": "Asn", "end_pos": 64, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn64", "evidence": [ { "id": "Q32PI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI9#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 206, "end_pos": 206, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PI9", "url": "https://www.uniprot.org/uniprotkb/Q32PI9" } ], "site_lbl": "Ser206" }, { "start_pos": 210, "end_pos": 210, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PI9", "url": "https://www.uniprot.org/uniprotkb/Q32PI9" } ], "site_lbl": "Ser210" }, { "start_pos": 219, "end_pos": 219, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PI9", "url": "https://www.uniprot.org/uniprotkb/Q32PI9" } ], "site_lbl": "Ser219" }, { "start_pos": 221, "end_pos": 221, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PI9", "url": "https://www.uniprot.org/uniprotkb/Q32PI9" } ], "site_lbl": "Ser221" }, { "start_pos": 241, "end_pos": 241, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q32PI9", "url": "https://www.uniprot.org/uniprotkb/Q32PI9" } ], "site_lbl": "Tyr241" }, { "start_pos": 260, "end_pos": 260, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PI9", "url": "https://www.uniprot.org/uniprotkb/Q32PI9" } ], "site_lbl": "Ser260" }, { "start_pos": 263, "end_pos": 263, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q32PI9", "url": "https://www.uniprot.org/uniprotkb/Q32PI9" } ], "site_lbl": "Tyr263" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Phosphorylation and localization of protein-zero related (PZR) in cultured endothelial cells.", "journal": "Endothelium : journal of endothelial cell research", "date": "2008", "authors": "Kusano K, Thomas TN, Fujiwara K", "evidence": [ { "database": "RefSeq", "id": "NP_001069626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069626" } ], "reference": [ { "type": "PubMed", "id": "18568953", "url": "https://glygen.org/publication/PubMed/18568953" } ] } ], "pathway": [ { "id": "bta:539387", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539387", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XW56-1", "protein_name": "Myelin protein zero like 1", "gene_name": "MPZL1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGARGGGSRKMAAAGGTAGRSAAVVAARLPLSACLLAAAASLAAVKVSAVEVTTPEEMFVENETDVKLPCTFTSAEVISSAASVSWSFQPEGAATRISFFYYSNGKPYTGKDIPFKDRVTWAGDLNKKDASISISNMQFQDNGTYICDVKNPPDIVVKPGEIRLRVVEKDSLPAFPIAMVAGIVIGTVTGLTLLISIVVCLVMRKNNSKKRYSGCGTSESLMSPVKQAPQKSPSDTEGLVNSVPARSHQGPVIYAQLDHSGGQHSDKINKSESVVYADIRKN", "length": 282 }, "evidence": [ { "id": "Q32PI9", "url": "https://omabrowser.org/oma/group/Q32PI9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E7F7T2-1", "protein_name": "Myelin protein zero-like 1 like", "gene_name": "mpzl1l", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEIRLPISSHSYVSLCVSAVFIIAGVSDVSAIDVFTTAEVFVENGTTATLSCSFRSKEVVSRLTTVTWSFLAEGESGASTTILYHSDGKSFPGALPQFKARVEWAGDMNKKDASIRVLQMQFKDNGTYSCDVKNPPDITGQSSPTKVRVVMKEALPQTSAAVIVGGVIGAVIGIILISVVTYLIIRRQKPSHDYEGCTSIESVSTQNTRVGKKAESSNDNSRCSSPSAPVQGPVIYAQLDHSGSKNSSSFHKMEPVVYADIRKN", "length": 264 }, "evidence": [ { "id": "Q32PI9", "url": "https://omabrowser.org/oma/group/Q32PI9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O95297-1", "protein_name": "Myelin protein zero-like protein 1", "gene_name": "MPZL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAASAGAGAVIAAPDSRRWLWSVLAAALGLLTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYTGCSTSESLSPVKQAPRKSPSDTEGLVKSLPSGSHQGPVIYAQLDHSGGHHSDKINKSESVVYADIRKN", "length": 269 }, "evidence": [ { "id": "Q32PI9", "url": "https://omabrowser.org/oma/group/Q32PI9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q3TEW6-1", "protein_name": "Myelin protein zero-like protein 1", "gene_name": "Mpzl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEAVGAVALIAAPARRRWLWSVLAAMLGLLTARISALEVHTPKEIFVVNGTQGKLTCTFDSPNTTGWLTTVSWSFQPDGTDSAVSFFHYSQGQVYIGDYPPFKDRVTWAGDLDKKDASINIENIQAVHNGTYICDVKNPPDIVVRPGHIRLHVVEIDNLLVFLVWVVVGTVTAVVLGLTLLISLVLVVLYRRKHSKRDYTGCSTSERLSPVKQAPRKCPSDTEGLVKSPPSAGSHQGPVIYAQLDHSGGHHSGKINKSESVVYADIRKD", "length": 270 }, "evidence": [ { "id": "Q32PI9", "url": "https://omabrowser.org/oma/group/Q32PI9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6AYT8-1", "protein_name": "Myelin protein zero-like protein 1", "gene_name": "Mpzl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEAVGAVTLIAAPARRRWLWSALAAMLGLLTARISALEVHTPKEIFVVNGTQGKLTCTFDSPNTTGWLTTVSWSFQPEGTDSAVSFFHYSQGQVYIGDYPPFKDRVTWAGDLDKKDASINIENIQAVHNGTYICDVKNPPDIVVRPGQIRLHVVEIDNLLVFLVWVVVGTVTAVVLGLTLLISLVLVVLYRRKHSKRDYTGCSTSERLSPVKQAPRKCPSDTEGLVKSPPSAGSHQGPVIYAQLDHSGGHHSGKINKSESVVYADIRKD", "length": 270 }, "evidence": [ { "id": "Q32PI9", "url": "https://omabrowser.org/oma/group/Q32PI9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q32PI9", "url": "https://www.uniprot.org/uniprotkb/Q32PI9" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q32PI9", "url": "https://www.uniprot.org/uniprotkb/Q32PI9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q32PI9", "url": "https://www.uniprot.org/uniprotkb/Q32PI9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" }, { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" }, { "start_pos": 64, "end_pos": 66, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PI9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 269, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PI9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PI9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 50, 64, 130 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 206, 210, 219, 221, 241, 260, 263 ], "sequon_annotation_sites": [ { "start_pos": 130, "end_pos": 132 }, { "start_pos": 204, "end_pos": 206 }, { "start_pos": 208, "end_pos": 210 }, { "start_pos": 256, "end_pos": 258 }, { "start_pos": 50, "end_pos": 52 }, { "start_pos": 64, "end_pos": 66 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3T168-1", "uniprot_ac": "Q3T168", "uniprot_id": "CYBP_BOVIN", "mass": { "chemical_mass": 26332.0, "monoisotopic_mass": 26332.0 }, "refseq": { "ac": "NP_001029981", "name": "calcyclin-binding protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029981" }, "gene_names": [ { "name": "CACYBP", "type": "recommended", "evidence": [ { "id": "Q3T168", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T168" } ] }, { "name": "CACYBP", "type": "synonym", "evidence": [ { "id": "NP_001029981", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029981" } ] } ], "protein_names": [ { "name": "Calcyclin-binding protein", "type": "recommended", "evidence": [ { "id": "Q3T168", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T168/entry#names_and_taxonomy" } ] }, { "name": "CacyBP", "type": "synonym", "evidence": [ { "id": "Q3T168", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T168/entry#names_and_taxonomy" } ] }, { "name": "calcyclin-binding protein", "type": "synonym", "evidence": [ { "id": "NP_001029981", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029981" } ] } ], "function": [ { "annotation": "May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYH6#function" }, { "database": "UniProtKB", "id": "ARBA00025145", "url": "https://www.uniprot.org/uniprotkb/ARBA00025145#function" }, { "database": "UniProtKB", "id": "A0AAA9SSW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSW9#function" }, { "database": "UniProtKB", "id": "A0AAA9TFR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFR3#function" }, { "database": "UniProtKB", "id": "Q3T168", "url": "https://www.uniprot.org/uniprotkb/Q3T168#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T168", "url": "https://www.uniprot.org/uniprotkb/Q3T168" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CACYBP", "url": "https://www.uniprot.org/uniprotkb/Q3T168", "locus": { "chromosome": "16", "start_pos": 56242610, "end_pos": 56229137, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001107", "url": "https://www.ensembl.org/id/ENSBTAG00000001107" } ] } } ], "crossref": [ { "id": "Q3T168", "url": "https://alphafold.ebi.ac.uk/entry/Q3T168", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001107", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001107", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06468", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06468", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "618428", "url": "https://www.ncbi.nlm.nih.gov/gene/618428", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007052", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007052", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007699", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007699", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008978", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008978", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015120", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015120", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037893", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037893", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052289", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052289", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618428", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618428", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YGWDQSA", "url": "https://omabrowser.org/oma/group/YGWDQSA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T168", "url": "https://www.orthodb.org/?gene=Q3T168", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13164", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13164", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13164:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13164:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04969", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04969", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05002", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05002", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09032", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09032", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029981", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SSW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSW9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T168", "url": "https://www.uniprot.org/uniprotkb/Q3T168", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T168-1", "url": "https://www.uniprot.org/uniprotkb/Q3T168-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSALEELQKDLEEVKVLLEKATRKRVRDALTAEKSKIETEMKNKMQQKSQRKAELTENEKPAAVVAPITTGYTVKISNYGWDQSDKFVKIYITLPGVHQVPAESVQVNFTERSFDLLVKNLNGKSYSMIVNNLLKPISVEGSSKKVKTDTVLILCRKKAENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAKGDTDF", "length": 230, "header": "sp|Q3T168-1|CYBP_BOVIN Isoform 1 of Calcyclin-binding protein OS=Bos taurus OX=9913 GN=CACYBP PE=2 SV=1 CANONICAL=Q3T168-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSW9-1", "url": "https://www.uniprot.org/uniprotkb/Q3T168/entry#A0AAA9SSW9-1", "sequence": { "sequence": "MRNPELQKDLEEVKVLLEKATRKRVRDALTAEKSKIETEMKNKMQQKSQRKAELTENEKPAAVVAPITTGYTVKISNYGWDQSDKFVKIYITLPGVHQVPAESVQVNFTERSFDLLVKNLNGKSYSMIVNNLLKPISVEGSSKKVKTDTVLILCRKKAENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAKGDTDF", "length": 228, "header": "tr|A0AAA9SSW9-1|CYBP_BOVIN Computationally mapped isoform of Calcyclin-binding protein OS=Bos taurus OX=9913 GN=CACYBP PE=2 SV=1 CANONICAL=Q3T168-1" }, "locus": { "chromosome": "16", "start_pos": 56242201, "end_pos": 56229336, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102891.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102891.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088444.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088444.1" } ] } }, { "isoform_ac": "A0AAA9SYH6-1", "url": "https://www.uniprot.org/uniprotkb/Q3T168/entry#A0AAA9SYH6-1", "sequence": { "sequence": "MDSSALVIFKLQKDLEEVKVLLEKATRKRVRDALTAEKSKIETEMKNKMQQKSQRKAELTENEKPAAVVAPITTGYTVKISNYGWDQSDKFVKIYITLPGVHQVPAESVQVNFTERSFDLLVKNLNGKSYSMIVNNLLKPISVEGSSKKVKTDTVLILCRKKAENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAKGDTDF", "length": 233, "header": "tr|A0AAA9SYH6-1|CYBP_BOVIN Computationally mapped isoform of Calcyclin-binding protein OS=Bos taurus OX=9913 GN=CACYBP PE=2 SV=1 CANONICAL=Q3T168-1" }, "locus": { "chromosome": "16", "start_pos": 56242201, "end_pos": 56233418, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108149.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108149.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090422.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090422.1" } ] } }, { "isoform_ac": "A0AAA9TFR3-1", "url": "https://www.uniprot.org/uniprotkb/Q3T168/entry#A0AAA9TFR3-1", "sequence": { "sequence": "MLQKDLEEVKVLLEKATRKRVRDALTAEKSKIETEMKNKMQQKSQRKAELTENEKPAAVVAPITTGYTVKISNYGWDQSDKFVKIYITLPGVHQVPAESVQVNFTERSFDLLVKNLNGKSYSMIVNNLLKPISVEGSSKKVKTDTVLILCRKKAENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAKGDTDF", "length": 224, "header": "tr|A0AAA9TFR3-1|CYBP_BOVIN Computationally mapped isoform of Calcyclin-binding protein OS=Bos taurus OX=9913 GN=CACYBP PE=2 SV=1 CANONICAL=Q3T168-1" }, "locus": { "chromosome": "16", "start_pos": 56242201, "end_pos": 56235416, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105089.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105089.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095850.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095850.1" } ] } }, { "isoform_ac": "Q3T168-1", "url": "https://www.uniprot.org/uniprotkb/Q3T168/entry#Q3T168-1", "sequence": { "sequence": "MSSALEELQKDLEEVKVLLEKATRKRVRDALTAEKSKIETEMKNKMQQKSQRKAELTENEKPAAVVAPITTGYTVKISNYGWDQSDKFVKIYITLPGVHQVPAESVQVNFTERSFDLLVKNLNGKSYSMIVNNLLKPISVEGSSKKVKTDTVLILCRKKAENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAKGDTDF", "length": 230, "header": "sp|Q3T168-1|CYBP_BOVIN Isoform 1 of Calcyclin-binding protein OS=Bos taurus OX=9913 GN=CACYBP PE=2 SV=1 CANONICAL=Q3T168-1" }, "locus": { "chromosome": "16", "start_pos": 56242201, "end_pos": 56231961, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001464.5", "url": "https://www.ensembl.org/id/ENSBTAT00000001464.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001464.3", "url": "https://www.ensembl.org/id/ENSBTAP00000001464.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 36, "end_pos": 36, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T168", "url": "https://www.uniprot.org/uniprotkb/Q3T168" } ], "site_lbl": "Ser36" }, { "start_pos": 3, "end_pos": 3, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T168", "url": "https://www.uniprot.org/uniprotkb/Q3T168" } ], "site_lbl": "Ser3" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618428", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618428", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YGN9-1", "protein_name": "Calcyclin-binding protein", "gene_name": "CACYBP", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRPRRRRRYTSVPLRGGGAGGRKVPEGLWSCRLCSGSAAQHCAACDMAAAREELQKDLEEVKELLAKATRKRLRDVLMMEKHKLELEIKNQPLPKPKDVIEEEKSSLGGYTVKINNYGWDQSDKFIKIYVSLNGVQKLPAENVQVNFTERSFDLLVKNLNGKNYTMTFNNLLKPISVEGSSRKIKTDTVLVMCKKKREEKWECLTQVEKESKEKEKAAYDTSDPSEGLMNLLKKMYAEGDDEMKRTINKAWVESREKQSKGDIPMDI", "length": 267 }, "evidence": [ { "id": "Q3T168", "url": "https://omabrowser.org/oma/group/Q3T168/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S710-1", "protein_name": "Calcyclin-binding protein", "gene_name": "CACYBP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASALEELQKDLEEVKVLLEKATRKRVRDTLTTEKSKIETEIKNKMQQKSQRKAELLENEKPAAVVAPITTGYTVKISNYGWDQSDKFVKIYITLTGVHQVPTENVQVHFTERSFDLLVKNLNGKNYSMIVNNLLKPISVEGSSKKVKTDTVLILCRKKAENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAKGDTEF", "length": 230 }, "evidence": [ { "id": "Q3T168", "url": "https://omabrowser.org/oma/group/Q3T168/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F4I4Q9-1", "protein_name": "Calcyclin-binding protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAEEVGLDLEELRQLQNIAKRPRVLNLINSEISNLEKLRDSAVSSNAKPKVPVTVPAPVSSSGKPVSSSALNYVTLGTFSWDQDNDKVKMYISLEGVDEDKVQAEFKPMSLDIKIHDVQGKNYRCAIPKLCKEIMPEKCKVLVKPKRIVITMVKSSRGNWLDIHHKEDKYCLLFVQIKPSLEKEKDPMAGIMGMMKNLYEDGDEEMKKTIAKAWTDARSGKAADPLKGL", "length": 229 }, "evidence": [ { "id": "Q3T168", "url": "https://omabrowser.org/oma/group/Q3T168/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9CXW3-1", "protein_name": "Calcyclin-binding protein", "gene_name": "Cacybp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASVLEELQKDLEEVKVLLEKSTRKRLRDTLTSEKSKIETELKNKMQQKSQKKPELDNEKPAAVVAPLTTGYTVKISNYGWDQSDKFVKIYITLTGVHQVPTENVQVHFTERSFDLLVKNLNGKNYSMIVNNLLKPISVESSSKKVKTDTVIILCRKKAENTRWDYLTQVEKECKEKEKPSYDTEADPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAREDTEF", "length": 229 }, "evidence": [ { "id": "Q3T168", "url": "https://omabrowser.org/oma/group/Q3T168/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HB71-1", "protein_name": "Calcyclin-binding protein", "gene_name": "CACYBP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASEELQKDLEEVKVLLEKATRKRVRDALTAEKSKIETEIKNKMQQKSQKKAELLDNEKPAAVVAPITTGYTVKISNYGWDQSDKFVKIYITLTGVHQVPTENVQVHFTERSFDLLVKNLNGKSYSMIVNNLLKPISVEGSSKKVKTDTVLILCRKKVENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAKGDTEF", "length": 228 }, "evidence": [ { "id": "Q3T168", "url": "https://omabrowser.org/oma/group/Q3T168/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9W3Y3-1", "protein_name": "Calcyclin-binding protein", "gene_name": "Dmel\\CG3226", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSLEQLKSDVAELAAFLQQAKGARVKDVLTTAKAEAEREIVNLELKAKIAAERQATGSSEAKRYLHELTDYGWDQSAKFVKLFITLNGVQGCTEENVTVTYTPNSLQLHVRDLQGKDFGLTVNNLLHSIDVEKSYRKIKTDMVAIYLQKVEDKHWDVLTAIQKRLKQKKDSELSKDGDNPESALVNIMKKMYNDGDSKTKQMIAKAWTESQDKAKLGKETGGGLDSFDDL", "length": 230 }, "evidence": [ { "id": "Q3T168", "url": "https://omabrowser.org/oma/group/Q3T168/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "Q3T168", "url": "https://www.uniprot.org/uniprotkb/Q3T168" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "Q3T168", "url": "https://www.uniprot.org/uniprotkb/Q3T168" } ], "pmid": "" }, { "name": "S100 protein binding", "id": "GO:0044548", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044548", "evidence": [ { "database": "UniProtKB", "id": "Q3T168", "url": "https://www.uniprot.org/uniprotkb/Q3T168" } ], "pmid": "" }, { "name": "tubulin binding", "id": "GO:0015631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015631", "evidence": [ { "database": "UniProtKB", "id": "Q3T168", "url": "https://www.uniprot.org/uniprotkb/Q3T168" } ], "pmid": "" }, { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "Q3T168", "url": "https://www.uniprot.org/uniprotkb/Q3T168" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q3T168", "url": "https://www.uniprot.org/uniprotkb/Q3T168" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3T168", "url": "https://www.uniprot.org/uniprotkb/Q3T168" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3T168", "url": "https://www.uniprot.org/uniprotkb/Q3T168" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "Q3T168", "url": "https://www.uniprot.org/uniprotkb/Q3T168" } ], "pmid": "" }, { "name": "beta-catenin destruction complex", "id": "GO:0030877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030877", "evidence": [ { "database": "UniProtKB", "id": "Q3T168", "url": "https://www.uniprot.org/uniprotkb/Q3T168" } ], "pmid": "" }, { "name": "nuclear envelope lumen", "id": "GO:0005641", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005641", "evidence": [ { "database": "UniProtKB", "id": "Q3T168", "url": "https://www.uniprot.org/uniprotkb/Q3T168" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3T168", "url": "https://www.uniprot.org/uniprotkb/Q3T168" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3T168", "url": "https://www.uniprot.org/uniprotkb/Q3T168" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "Q3T168", "url": "https://www.uniprot.org/uniprotkb/Q3T168" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T168-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 230, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T168-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T168" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3T168", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T168" }, { "id": "PRU00547", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00547" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CS", "eco_id": "ECO_0000255", "start_pos": 75, "end_pos": 169, "start_aa": "Val", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T168", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T168" }, { "id": "PRU00386", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00386" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SGS", "eco_id": "ECO_0000255", "start_pos": 170, "end_pos": 230, "start_aa": "Gln", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 3, 36 ], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 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"synonym", "evidence": [ { "id": "NP_001029963", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029963" } ] }, { "name": "ragulator complex protein LAMTOR2", "type": "synonym", "evidence": [ { "id": "NP_001029963", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029963" } ] }, { "name": "roadblock domain containing 3", "type": "synonym", "evidence": [ { "id": "NP_001029963", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029963" } ] }, { "name": "roadblock domain-containing protein 3", "type": "synonym", "evidence": [ { "id": "NP_001029963", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029963" } ] } ], "function": [ { "annotation": "As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity). Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T132", "url": "https://www.uniprot.org/uniprotkb/Q3T132#function" }, { "database": "UniProtKB", "id": "Q9Y2Q5", "url": "https://www.uniprot.org/uniprotkb/Q9Y2Q5#function" }, { "database": "UniProtKB", "id": "Q9JHS3", "url": "https://www.uniprot.org/uniprotkb/Q9JHS3#function" }, { "database": "UniProtKB", "id": "A0AAA9SUB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUB1#function" }, { "database": "UniProtKB", "id": "ARBA00045176", "url": "https://www.uniprot.org/uniprotkb/ARBA00045176#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T132", "url": "https://www.uniprot.org/uniprotkb/Q3T132" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LAMTOR2", "url": "https://www.uniprot.org/uniprotkb/Q3T132", "locus": { "chromosome": "3", "start_pos": 14708877, "end_pos": 14712267, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011754", "url": "https://www.ensembl.org/id/ENSBTAG00000011754" } ] } } ], "crossref": [ { "id": "Q3T132", "url": "https://alphafold.ebi.ac.uk/entry/Q3T132", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011754", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011754", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616375", "url": "https://www.ncbi.nlm.nih.gov/gene/616375", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037587", "url": 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"Enzyme and Pathway" ] }, { "id": "R-BTA-165159", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-165159", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-166208", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-166208", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380972", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380972", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5628897", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5674135", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8943724", "url": 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"MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDNLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS", "length": 125, "header": "sp|Q3T132-1|LTOR2_BOVIN Isoform 1 of Ragulator complex protein LAMTOR2 OS=Bos taurus OX=9913 GN=LAMTOR2 PE=2 SV=1 CANONICAL=Q3T132-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUB1-1", "url": "https://www.uniprot.org/uniprotkb/Q3T132/entry#A0AAA9SUB1-1", "sequence": { "sequence": "MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDNLKFILMDCMAQALVQYLEEPLTQVAAS", "length": 95, "header": "tr|A0AAA9SUB1-1|LTOR2_BOVIN Computationally mapped isoform of Ragulator complex protein LAMTOR2 OS=Bos taurus OX=9913 GN=LAMTOR2 PE=2 SV=1 CANONICAL=Q3T132-1" }, "locus": { "chromosome": "3", "start_pos": 14712216, "end_pos": 14709341, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115149.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115149.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087736.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087736.1" } ] } }, { "isoform_ac": "Q3T132-1", "url": "https://www.uniprot.org/uniprotkb/Q3T132/entry#Q3T132-1", "sequence": { "sequence": "MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDNLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS", "length": 125, "header": "sp|Q3T132-1|LTOR2_BOVIN Isoform 1 of Ragulator complex protein LAMTOR2 OS=Bos taurus OX=9913 GN=LAMTOR2 PE=2 SV=1 CANONICAL=Q3T132-1" }, "locus": { "chromosome": "3", "start_pos": 14712216, "end_pos": 14709341, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048084.3", "url": "https://www.ensembl.org/id/ENSBTAT00000048084.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045185.1", "url": "https://www.ensembl.org/id/ENSBTAP00000045185.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616375", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616375", "resource": "KEGG Pathway" }, { "id": "R-BTA-1632852", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "resource": "Reactome", "description": "Macroautophagy" }, { "id": "R-BTA-165159", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-165159", "resource": "Reactome", "description": "MTOR signalling" }, { "id": "R-BTA-166208", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-166208", "resource": "Reactome", "description": "mTORC1-mediated signalling" }, { "id": "R-BTA-380972", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380972", "resource": "Reactome", "description": "Energy dependent regulation of mTOR by LKB1-AMPK" }, { "id": "R-BTA-5628897", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5628897", "resource": "Reactome", "description": "TP53 Regulates Metabolic Genes" }, { "id": "R-BTA-5674135", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5674135", "resource": "Reactome", "description": "MAP2K and MAPK activation" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-BTA-8943724", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8943724", "resource": "Reactome", "description": "Regulation of PTEN gene transcription" }, { "id": "R-BTA-9639288", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9639288", "resource": "Reactome", "description": "Amino acids regulate mTORC1" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1B0GWT7-1", "protein_name": "Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2", "gene_name": "Lamtor2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "PESGASSQPHSAPPCRRPAARQPAQLLLLLLLLARPARLGSGASNSPSRPSPRLRRPLRTAAATAPRAAWGGTAVGAARARAGCAAGPGRIVRPAQRAGDSGPPAVPSRLDKGLSVSPSHLRSPRLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDSLKFILMDCMDQRNPGEGRNQGCQAECPSVLCHSHQEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS", "length": 253 }, "evidence": [ { "id": "Q3T132", "url": "https://omabrowser.org/oma/group/Q3T132/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V1AEX1-1", "protein_name": "Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2", "gene_name": "LAMTOR2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWVAYDKNGHHAFNEDNLRFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS", "length": 125 }, "evidence": [ { "id": "Q3T132", "url": "https://omabrowser.org/oma/group/Q3T132/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F2Z518-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDNLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS", "length": 125 }, "evidence": [ { "id": "Q3T132", "url": "https://omabrowser.org/oma/group/Q3T132/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HG98-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "Lamtor2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDNLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS", "length": 125 }, "evidence": [ { "id": "Q3T132", "url": "https://omabrowser.org/oma/group/Q3T132/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q54F59-1", "protein_name": "Roadblock/LAMTOR2 domain-containing protein", "gene_name": "mapbpip", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLRSKILPQILNQAINNTDTKGVLLMKDDGSLIACSDATTSSHNTSKIVAAITSNIWTAYNRNSDLQYQLIDCEEGRFVITRVASLLLCVYSDINTEFGLLKLKTQKLREYLEEPLSKVEHVQ", "length": 123 }, "evidence": [ { "id": "Q3T132", "url": "https://omabrowser.org/oma/group/Q3T132/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6DEG4-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "lamtor2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLRPKALTQVLSQANTSGVQSTLLLNNEGSLLTYSGYGDTDARVTAAIASNIWAAYDKNGHQAFNEDKLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAEALVQYLEEPLTQVAAS", "length": 125 }, "evidence": [ { "id": "Q3T132", "url": "https://omabrowser.org/oma/group/Q3T132/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9JHS3-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "Lamtor2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDSLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS", "length": 125 }, "evidence": [ { "id": "Q3T132", "url": "https://omabrowser.org/oma/group/Q3T132/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9V8I2-1", "protein_name": "Ragulator complex protein LAMTOR2 homolog", "gene_name": "Lamtor2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLKPKALTQVLSQANTGGVENTLLLSQEGALLAYSGYGDKDARITAAIASNIWAAYEKHGRNAFREGRLTFVLIDCENGHVAITQVASVLLCLYAKQTVGLGLLKQKAMSLASYLERPLKQISAS", "length": 125 }, "evidence": [ { "id": "Q3T132", "url": "https://omabrowser.org/oma/group/Q3T132/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDNLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS", "length": 125 }, "evidence": [ { "id": "Q3T132", "url": "https://omabrowser.org/oma/group/Q3T132/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "positive regulation of TORC1 signaling", "id": "GO:1904263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904263", "evidence": [ { "database": "UniProtKB", "id": "Q3T132", "url": "https://www.uniprot.org/uniprotkb/Q3T132" } ], "pmid": "" }, { "name": "regulation of cell growth", "id": "GO:0001558", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001558", "evidence": [ { "database": "UniProtKB", "id": "Q3T132", "url": "https://www.uniprot.org/uniprotkb/Q3T132" } ], "pmid": "" }, { "name": "positive regulation of TOR signaling", "id": "GO:0032008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032008", "evidence": [ { "database": "UniProtKB", "id": "Q3T132", "url": "https://www.uniprot.org/uniprotkb/Q3T132" } ], "pmid": "" }, { "name": "intracellular protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "Q3T132", "url": "https://www.uniprot.org/uniprotkb/Q3T132" } ], "pmid": "" }, { "name": "cellular response to amino acid stimulus", "id": "GO:0071230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071230", "evidence": [ { "database": "UniProtKB", "id": "Q3T132", "url": "https://www.uniprot.org/uniprotkb/Q3T132" } ], "pmid": "" }, { "name": "regulation of cell-substrate junction organization", "id": "GO:0150116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150116", "evidence": [ { "database": "UniProtKB", "id": "Q3T132", "url": "https://www.uniprot.org/uniprotkb/Q3T132" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "Q3T132", "url": "https://www.uniprot.org/uniprotkb/Q3T132" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "Q3T132", "url": "https://www.uniprot.org/uniprotkb/Q3T132" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "Q3T132", "url": "https://www.uniprot.org/uniprotkb/Q3T132" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "Q3T132", "url": "https://www.uniprot.org/uniprotkb/Q3T132" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "Q3T132", "url": "https://www.uniprot.org/uniprotkb/Q3T132" } ], "pmid": "" }, { "name": "Ragulator complex", "id": "GO:0071986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071986", "evidence": [ { "database": "UniProtKB", "id": "Q3T132", "url": "https://www.uniprot.org/uniprotkb/Q3T132" } ], "pmid": "" }, { "name": "FNIP-folliculin RagC/D GAP", "id": "GO:1990877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990877", "evidence": [ { "database": "UniProtKB", "id": "Q3T132", "url": "https://www.uniprot.org/uniprotkb/Q3T132" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T132-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 125, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T132-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T132" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0J1-1", "uniprot_ac": "Q3T0J1", "uniprot_id": "FBX4_BOVIN", "mass": { "chemical_mass": 43965.0, "monoisotopic_mass": 43965.0 }, "refseq": { "ac": "NP_001029789", "name": "F-box only protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029789" }, "gene_names": [ { "name": "FBXO4", "type": "recommended", "evidence": [ { "id": "Q3T0J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" } ] }, { "name": "FBXO4", "type": "synonym", "evidence": [ { "id": "NP_001029789", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029789" } ] } ], "protein_names": [ { "name": "F-box only protein 4", "type": "recommended", "evidence": [ { "id": "Q3T0J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1/entry#names_and_taxonomy" } ] }, { "name": "F-box only protein 4", "type": "synonym", "evidence": [ { "id": "NP_001029789", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029789" } ] } ], "function": [ { "annotation": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of cyclin-D1 (CCND1) and its subsequent proteasomal degradation. However, it does not act as a major regulator of CCND1 stability during the G1/S transition. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1. Promotes ubiquitination of FXR1 following phosphorylation of FXR1 by GSK3B, leading to FXR1 degradation by the proteasome.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1#function" }, { "database": "UniProtKB", "id": "Q9UKT5", "url": "https://www.uniprot.org/uniprotkb/Q9UKT5#function" }, { "database": "UniProtKB", "id": "A0AAA9SXU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXU4#function" }, { "database": "UniProtKB", "id": "ARBA00093321", "url": "https://www.uniprot.org/uniprotkb/ARBA00093321#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO4", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1", "locus": { "chromosome": "20", "start_pos": 32589653, "end_pos": 32603041, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016981", "url": "https://www.ensembl.org/id/ENSBTAG00000016981" } ] } } ], "crossref": [ { "id": "Q3T0J1", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0J1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016981", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016981", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11656", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11656", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22085", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22085", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534852", "url": "https://www.ncbi.nlm.nih.gov/gene/534852", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039588", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039588", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534852", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534852", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HYSVIAQ", "url": "https://omabrowser.org/oma/group/HYSVIAQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0J1", "url": "https://www.orthodb.org/?gene=Q3T0J1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16008", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16008", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16008:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16008:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029789", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SXU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXU4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXU4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0J1-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGSDPGSRGSSPQPPHSDWGRLEAAFLSGWRNFWQSVGKERAAPRASAEEVDEEASSLTRLPIDVQLYILSFLSPHDLCQLGSTSRYWNETVRDPILWRYFLLRDLPSWSSVDWKSLPDLEILKKPISEVTNGAFFDYMAVYKMCCPHTRRSSKSSRPMYGAVTSFLHSLIIQNEPRFAMFGPGLEELNTSLVLSLMSSEELCPTAGLPQRQIDGIGSGVSFQLNNQHKFNILILYSTTRKERDRAREEHTSAVNKMFSVQNEGDDQQGSRYSVIPQIQKVCEVVDGFIYVANAEAHKRHEWQDEFSRIMAMTDPAFGSSGRPMLVLSCISQANVKRMPCFYLAHELRLNHLNHPWMVQDTEAETLTGFLNGIQWILEEVESKHAR", "length": 387, "header": "sp|Q3T0J1-1|FBX4_BOVIN Isoform 1 of F-box only protein 4 OS=Bos taurus OX=9913 GN=FBXO4 PE=2 SV=1 CANONICAL=Q3T0J1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SXU4-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1/entry#A0AAA9SXU4-1", "sequence": { "sequence": "MSSTQRGTALGEVTQLQRSKGRELLNQWVRSARLRLRPLSEGRSDFWWELQAPLRTTLNWAISLPGSEGFFVCGGTGIDVQLYILSFLSPHDLCQLGSTSRYWNETVRDPILWRYFLLRDLPSWSSVDWKSLPDLEILKKPISEVTNGAFFDYMAVYKMCCPHTRRSSKSSRPMYGAVTSFLHSLIIQNEPRFAMFGPGLEELNTSLVLSLMSSEELCPTAGLPQRQIDGIGSGVSFQLNNQHKFNILILYSTTRKERDRAREEHTSAVNKMFSVQNEGDDQQGSRYSVIPQIQKVCEVVDGFIYVANAEAHKRHEWQDEFSRIMAMTDPAFGSSGRPMLVLSCISQANVKRMPCFYLAHELRLNHLNHPWMVQDTEAETLTGFLNGIQWILEEVESKHAR", "length": 401, "header": "tr|A0AAA9SXU4-1|FBX4_BOVIN Computationally mapped isoform of F-box only protein 4 OS=Bos taurus OX=9913 GN=FBXO4 PE=2 SV=1 CANONICAL=Q3T0J1-1" }, "locus": { "chromosome": "20", "start_pos": 32602842, "end_pos": 32589930, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128339.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128339.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089055.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089055.1" } ] } }, { "isoform_ac": "Q3T0J1-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1/entry#Q3T0J1-1", "sequence": { "sequence": "MAGSDPGSRGSSPQPPHSDWGRLEAAFLSGWRNFWQSVGKERAAPRASAEEVDEEASSLTRLPIDVQLYILSFLSPHDLCQLGSTSRYWNETVRDPILWRYFLLRDLPSWSSVDWKSLPDLEILKKPISEVTNGAFFDYMAVYKMCCPHTRRSSKSSRPMYGAVTSFLHSLIIQNEPRFAMFGPGLEELNTSLVLSLMSSEELCPTAGLPQRQIDGIGSGVSFQLNNQHKFNILILYSTTRKERDRAREEHTSAVNKMFSVQNEGDDQQGSRYSVIPQIQKVCEVVDGFIYVANAEAHKRHEWQDEFSRIMAMTDPAFGSSGRPMLVLSCISQANVKRMPCFYLAHELRLNHLNHPWMVQDTEAETLTGFLNGIQWILEEVESKHAR", "length": 387, "header": "sp|Q3T0J1-1|FBX4_BOVIN Isoform 1 of F-box only protein 4 OS=Bos taurus OX=9913 GN=FBXO4 PE=2 SV=1 CANONICAL=Q3T0J1-1" }, "locus": { "chromosome": "20", "start_pos": 32602481, "end_pos": 32589930, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022583.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022583.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022583.5", "url": "https://www.ensembl.org/id/ENSBTAP00000022583.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 11, "end_pos": 11, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" } ], "site_lbl": "Ser11" }, { "start_pos": 12, "end_pos": 12, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" } ], "site_lbl": "Ser12" }, { "start_pos": 48, "end_pos": 48, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" } ], "site_lbl": "Ser48" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534852", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534852", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480JTG0-1", "protein_name": "F-box only protein 4", "gene_name": "FBXO4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGSEAGSRGSSPQPHHSDWGRLEAAILSGWRSFWQSVGKERAAPRASPEEADEEGNPLSRLPIDVQLYILSFLSPHDLCQLGSTSHYWNETVRDPILWRYFLLRDLPSWSSVDWKSLPDLEILKKPIFEVTAGSFFDYMAVYKMCCPYTRRASKSSRPMYGAVTSFLHSLIIQNEPRFAMFGPGLEELNTSLVLSLMSSEELCPTAGLPQRQIDGIGSGVSFQLHNQHKFNILILYSTTRKERDRAREEHTSAVNKMFSLQNEGDDQQGSRYSVIPQIQKVCEVVDGFIYVANAEAHKRHEWQDEFSRIMAMTDPAFGSSGRPMLVLSCISQANVKRMPCFYLAHELHLNHLNHPWMVQDTEAETLTGFSNGIQWILEEVESKHAR", "length": 387 }, "evidence": [ { "id": "Q3T0J1", "url": "https://omabrowser.org/oma/group/Q3T0J1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZIH4-1", "protein_name": "F-box only protein 4", "gene_name": "Fbxo4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSHSGPPRPGAAPSRPAWLVPAGRAETEAERLGNRCARPCLAEPAAMAGSEPRGAGSPPPASDWGRLEAAILSGWRTFWNSVGKERATRTASRKEEAEETSALTRLPIDVQLYILSFLSPHDLCQLGSTDHYWNETVRDPILWRYFLFRDLPSWSSVDWKSLPDLEILKKPISEVTDSTCFDYMEVYKMCCPYTRRALKASRPMYGAVTSFLHSLIIQNEPRFAMFGPGLEELNTSLVLSLMSSEDLCPTAGLPHRQIDGIGSGVSFQLSNQHKFNILILYSTTRKERDRAREEHTSTVNKMFSLQSEGDEQQGSRYSVIPQIQKVCEVVDGFIYVANAEAHRRHEWQDEFSRIMAMTDPAFGSSGRPMLVLSCISQADVKRMPCFYLAHELRLSLLNHPWMVQDTEAETLTGFLNGIEWILEEVESKHAK", "length": 431 }, "evidence": [ { "id": "Q3T0J1", "url": "https://omabrowser.org/oma/group/Q3T0J1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8CHQ0-1", "protein_name": "F-box only protein 4", "gene_name": "Fbxo4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGSEPRGAGSPPPASDWGRLEAAILSGWRTFWYSVAKERATPTASRKEAAEETSALTRLPVDVQLYILSFLSPHDLCQLGSTDHYWNKTIRDPILWRYFLLRDLPSWSSVDWKSLPDLEILKKPISEVTDSTCLDYMEVYKMCCPYTRRALKASRPMYGVVTSFLHSLIIQNEPRFAMFGPGLEELNTSLVLSLMSSEDLCPTAGLPHRQIDGIGSGVNFQLNNQQKFNILILYSTTRKERDRAREEHTSTVNKMFSLQSEGDEQQGSRYSVIPQIQKVCEVVDGFIYVANAEAHRRHEWQDEFSRIMAMTDPAFGSSGRPMLVLSCISQADVKRMPCFYLAHELHLSLLNHPWMVQDTEAETLTGFLNGIEWILEEVESKRAK", "length": 385 }, "evidence": [ { "id": "Q3T0J1", "url": "https://omabrowser.org/oma/group/Q3T0J1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UKT5-1", "protein_name": "F-box only protein 4", "gene_name": "FBXO4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGSEPRSGTNSPPPPFSDWGRLEAAILSGWKTFWQSVSKERVARTTSREEVDEAASTLTRLPIDVQLYILSFLSPHDLCQLGSTNHYWNETVRDPILWRYFLLRDLPSWSSVDWKSLPDLEILKKPISEVTDGAFFDYMAVYRMCCPYTRRASKSSRPMYGAVTSFLHSLIIQNEPRFAMFGPGLEELNTSLVLSLMSSEELCPTAGLPQRQIDGIGSGVNFQLNNQHKFNILILYSTTRKERDRAREEHTSAVNKMFSRHNEGDDQQGSRYSVIPQIQKVCEVVDGFIYVANAEAHKRHEWQDEFSHIMAMTDPAFGSSGRPLLVLSCISQGDVKRMPCFYLAHELHLNLLNHPWLVQDTEAETLTGFLNGIEWILEEVESKRAR", "length": 387 }, "evidence": [ { "id": "Q3T0J1", "url": "https://omabrowser.org/oma/group/Q3T0J1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "telomere maintenance", "id": "GO:0000723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000723", "evidence": [ { "database": "UniProtKB", "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" } ], "pmid": "" }, { "name": "regulation of protein stability", "id": "GO:0031647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647", "evidence": [ { "database": "UniProtKB", "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" } ], "pmid": "" }, { "name": "positive regulation of protein ubiquitination", "id": "GO:0031398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031398", "evidence": [ { "database": "UniProtKB", "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" } ], "pmid": "" }, { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" } ], "pmid": "" }, { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" } ], "pmid": "" }, { "name": "regulation of macromolecule biosynthetic process", "id": "GO:0010556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010556", "evidence": [ { "database": "UniProtKB", "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" } ], "pmid": "" }, { "name": "positive regulation of telomere maintenance via telomerase", "id": "GO:0032212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032212", "evidence": [ { "database": "UniProtKB", "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" } ], "pmid": "" }, { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "Q3T0J1", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0J1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 387, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0J1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0J1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3T0J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0J1" }, { "id": "PRU00080", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00080" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000255", "start_pos": 56, "end_pos": 102, "start_aa": "Ala", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 11, 12, 48 ], "sequon_annotation_sites": [ { "start_pos": 190, "end_pos": 192 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHF7-1", "uniprot_ac": "Q3MHF7", "uniprot_id": "MTAP_BOVIN", "mass": { "chemical_mass": 31256.0, "monoisotopic_mass": 31256.0 }, "refseq": { "ac": "XP_002689552", "name": "S-methyl-5'-thioadenosine phosphorylase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689552" }, "gene_names": [ { "name": "MTAP", "type": "recommended", "evidence": [ { "id": "Q3MHF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7" } ] }, { "name": "MTAP", "type": "synonym", "evidence": [ { "id": "XP_002689552", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689552" } ] } ], "protein_names": [ { "name": "S-methyl-5'-thioadenosine phosphorylase", "type": "recommended", "evidence": [ { "id": "Q3MHF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7/entry#names_and_taxonomy" } ] }, { "name": "2.4.2.28", "type": "synonym", "evidence": [ { "id": "Q3MHF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7/entry#names_and_taxonomy" } ] }, { "name": "5'-methylthioadenosine phosphorylase", "type": "synonym", "evidence": [ { "id": "Q3MHF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7/entry#names_and_taxonomy" } ] }, { "name": "MTA phosphorylase", "type": "synonym", "evidence": [ { "id": "Q3MHF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7/entry#names_and_taxonomy" } ] }, { "name": "MTAPase", "type": "synonym", "evidence": [ { "id": "Q3MHF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7/entry#names_and_taxonomy" } ] }, { "name": "MTAP", "type": "synonym", "evidence": [ { "id": "Q3MHF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7/entry#names_and_taxonomy" } ] }, { "name": "S-methyl-5'-thioadenosine phosphorylase", "type": "synonym", "evidence": [ { "id": "XP_002689552", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689552" } ] } ], "function": [ { "annotation": "Catalyzes the phosphorolytic cleavage of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.", "evidence": [ { "database": "UniProtKB", "id": "Q3MHF7", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7#function" }, { "database": "HAMAP", "id": "MF_03155", "url": "https://hamap.expasy.org/signature/MF_03155" }, { "database": "PubMed", "id": "2108157", "url": "https://glygen.org/publication/PubMed/2108157" } ] }, { "annotation": "Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHL8#function" }, { "database": "HAMAP", "id": "MF_03155", "url": "https://hamap.expasy.org/signature/MF_03155" }, { "database": "UniProtKB", "id": "ARBA00057208", "url": "https://www.uniprot.org/uniprotkb/ARBA00057208#function" }, { "database": "UniProtKB", "id": "A0AAA9SY33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY33#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHF7", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MTAP", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7", "locus": {} } ], "crossref": [ { "id": "Q3MHF7", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHF7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025929", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025929", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09010", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09010", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "782907", "url": "https://www.ncbi.nlm.nih.gov/gene/782907", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000845", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000845", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018099", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782907", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782907", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ADPFCPE", "url": "https://omabrowser.org/oma/group/ADPFCPE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3MHF7", "url": "https://www.orthodb.org/?gene=Q3MHF7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42679", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42679", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42679:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42679:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01048", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01048", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1237112", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1237112", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002689552", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689552", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11852", "url": "https://www.rhea-db.org/rhea/11852", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SY33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY33-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZHL8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZHL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHL8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHF7", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHF7-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSGATPAAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALVLGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLKEEIQPGDIIIIDQFIDRTTRRLQTFYDGNHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMITIEGPRFSSRAESIMFQTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSMEWSETLHNMKKMAQFSVLLPRH", "length": 283, "header": "sp|Q3MHF7-1|MTAP_BOVIN Isoform 1 of S-methyl-5'-thioadenosine phosphorylase OS=Bos taurus OX=9913 GN=MTAP PE=1 SV=1 CANONICAL=Q3MHF7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SY33-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7/entry#A0AAA9SY33-1", "sequence": { "sequence": "MDKEMIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALVLGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLKEEIQPGDIIIIDQFIDRTTRRLQTFYDGNHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMITIEGPRFSSRAESIMFQTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSMEWSETLHNMKKMAQFSVLLPRH", "length": 277, "header": "tr|A0AAA9SY33-1|MTAP_BOVIN Computationally mapped isoform of S-methyl-5'-thioadenosine phosphorylase OS=Bos taurus OX=9913 GN=MTAP PE=1 SV=1 CANONICAL=Q3MHF7-1" }, "locus": { "chromosome": "8", "start_pos": 22232704, "end_pos": 22191381, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097674.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097674.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088227.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088227.1" } ] } }, { "isoform_ac": "A0AAF6ZHL8-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7/entry#A0AAF6ZHL8-1", "sequence": { "sequence": "MSSGATPAAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALVLGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLKEEIQPGDIIIIDQFIDRTTRRLQTFYDGNHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMITIEGPRFSSRAESIMFQTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSMEWSETLHNMKIGSFSTLVLIPRI", "length": 284, "header": "tr|A0AAF6ZHL8-1|MTAP_BOVIN Computationally mapped isoform of S-methyl-5'-thioadenosine phosphorylase OS=Bos taurus OX=9913 GN=MTAP PE=1 SV=1 CANONICAL=Q3MHF7-1" }, "locus": { "chromosome": "8", "start_pos": 22236705, "end_pos": 22193501, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048509.5", "url": "https://www.ensembl.org/id/ENSBTAT00000048509.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045533.5", "url": "https://www.ensembl.org/id/ENSBTAP00000045533.5" } ] } }, { "isoform_ac": "Q3MHF7-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7/entry#Q3MHF7-1", "sequence": { "sequence": "MSSGATPAAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALVLGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLKEEIQPGDIIIIDQFIDRTTRRLQTFYDGNHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMITIEGPRFSSRAESIMFQTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSMEWSETLHNMKKMAQFSVLLPRH", "length": 283, "header": "sp|Q3MHF7-1|MTAP_BOVIN Isoform 1 of S-methyl-5'-thioadenosine phosphorylase OS=Bos taurus OX=9913 GN=MTAP PE=1 SV=1 CANONICAL=Q3MHF7-1" }, "locus": { "chromosome": "8", "start_pos": 22236705, "end_pos": 22191381, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110113.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110113.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075535.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075535.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 6, "start_aa": "Thr", "end_pos": 6, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr6", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycosyltransferase-activity", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "A whole-genome assembly of the domestic cow, Bos taurus.", "journal": "Genome Biol.", "date": "2009", "authors": "Zimin Aleksey V, Delcher Arthur L, Florea Liliana, Kelley David R, Schatz Michael C, Puiu Daniela, Hanrahan Finnian, Pertea Geo, Van Tassell Curtis P, Sonstegard Tad S, Mar\u00e7ais Guillaume, Roberts Michael, Subramanian Poorani, Yorke James A, Salzberg Steven L", "evidence": [ { "database": "UniProtKB", "id": "Q3MHF7", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7" } ], "reference": [ { "type": "PubMed", "id": "19393038", "url": "https://glygen.org/publication/PubMed/19393038" } ] }, { "title": "Physicochemical and immunological studies on mammalian 5'-deoxy-5'-methylthioadenosine phosphorylase.", "journal": "The Journal of biological chemistry", "date": "1990-04-15", "authors": "Della Ragione F, Oliva A, Gragnaniello V, Russo G L, Palumbo R, Zappia V", "evidence": [ { "database": "UniProtKB", "id": "Q3MHF7", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7" } ], "reference": [ { "type": "PubMed", "id": "2108157", "url": "https://glygen.org/publication/PubMed/2108157" } ] } ], "pathway": [ { "id": "bta:782907", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782907", "resource": "KEGG Pathway" }, { "id": "R-BTA-1237112", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1237112", "resource": "Reactome", "description": "Methionine salvage pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K583-1", "protein_name": "S-methyl-5'-thioadenosine phosphorylase", "gene_name": "Mtap", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASGSACTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRHHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDMVIIDQFIDRTSLRPQTFYDGSHCSARGVCHIPMAEPFCPKTREVLIEMAKKLGLRCHSKGTIVTIEGPRFSSRAESFIFRTWGADVINMTTVPEVVLAKEAGLCYASIAMATDYDCWKEHEEAVSVDGVLKTMKENANKAKSLLLTTIPQIGSMEWSETLRNLKNMAQSSVLPPRH", "length": 283 }, "evidence": [ { "id": "Q3MHF7", "url": "https://omabrowser.org/oma/group/Q3MHF7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8C2MQT0-1", "protein_name": "S-methyl-5'-thioadenosine phosphorylase", "gene_name": "Mtap", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASGAACTPVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVLVTTACGSLREEIQPGDMVIIDQFIDRTSLRPQTFYDGSHCSARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTIVTIEGPRFSSRAESFVFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDGVLKTMKENANKAKSLLLTTIPQIGSMEWSETLRNLKNMAQCSVLPPRH", "length": 283 }, "evidence": [ { "id": "Q3MHF7", "url": "https://omabrowser.org/oma/group/Q3MHF7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1NCV7-1", "protein_name": "S-methyl-5'-thioadenosine phosphorylase", "gene_name": "MTAP", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAATAAVKIGIIGGTGLDDPDILEERTEKYVDTPYGKPSDALILGKIKNVDCVLLARHGRHHTIMPSNVNYRANIWALKEENCSHVLVTTACGSLREEIQPGDLVIIDQFIDRTTKRHCTLYDGQSCSLSGVCHIPMSEPFCTKTREVLIEIAKKLGLQCHSKGTMITIEGPRFSSRAESLMFRSWGADVINMTTVPEVILAKEAGMSYASIAMATDYDCWKEHEEAVSVDKVLKTLKENANKATSILLTAIPQIGSMEWTDTLHTLKTTVQCSVILPKQ", "length": 280 }, "evidence": [ { "id": "Q3MHF7", "url": "https://omabrowser.org/oma/group/Q3MHF7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q07938-1", "protein_name": "S-methyl-5'-thioadenosine phosphorylase", "gene_name": "MEU1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MNRIKNTFSVAKRLKLSKVMTNSELPSIFEGTVDLGIIGGTGLYNLDCLEPIALLPPMVTPWGTTSSPVTISQFVGTNSHFHVAFIARHGINHEYPPTKVPFRANMAALKNLNCKAVLSFSAVGSLQPHIKPRDFVLPQQIIDRTKGIRHSSYFNDEGLVGHVGFGQPFSQKFAEYIYQFKNEITNPESEEPCHLHYDKDMTVVCMEGPQFSTRAESKMYRMFGGHVINMSVIPEAKLARECELPYQMICMSTDYDAWRDEAEPVTVETVIGNLTNNGRNANILASKIIVSMAKEIPEFMHTGDGLRGSIKKSISTKPEAMSKETLERLRYLFPNYW", "length": 337 }, "evidence": [ { "id": "Q3MHF7", "url": "https://omabrowser.org/oma/group/Q3MHF7/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q13126-1", "protein_name": "S-methyl-5'-thioadenosine phosphorylase", "gene_name": "MTAP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH", "length": 283 }, "evidence": [ { "id": "Q3MHF7", "url": "https://omabrowser.org/oma/group/Q3MHF7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7ZV22-1", "protein_name": "S-methyl-5'-thioadenosine phosphorylase", "gene_name": "mtap", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTSNSHVKIGIIGGSGLDDPDILEGRTERYVVTPYGKPSDALILGKIKNVDCVLLARHGRQHTIMPTNVNYQANIWALKEEGCTHLLVTTACGSLREDIQPGDIVLIDQFIDRTTKRVQTFYDGQPTSPPGVCHIPMAEPFCSKTREVLLEVAQGLGVKCHTRGTMVTIEGPRFSSRAESLMFRQWGADVINMTTVPEVVLAKEAGLCYASIAMATDYDCWKEHEEAVCVDNVLKTMKENANKASSILLTAIPQICQMDWDSTINAHKSMSQSSVMLPKH", "length": 280 }, "evidence": [ { "id": "Q3MHF7", "url": "https://omabrowser.org/oma/group/Q3MHF7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9CQ65-1", "protein_name": "S-methyl-5'-thioadenosine phosphorylase", "gene_name": "Mtap", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASGSACTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDMVIIDQFIDRTSLRPQTFYDGSHCSARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTIVTIEGPRFSSRAESLIFRTWGADVVNMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDGVLKTMKENANKAKSLLLTTIPQIGSMEWSETLRNLKNMAQFSVLPPRH", "length": 283 }, "evidence": [ { "id": "Q3MHF7", "url": "https://omabrowser.org/oma/group/Q3MHF7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9V813-1", "protein_name": "S-methyl-5'-thioadenosine phosphorylase", "gene_name": "Mtap", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MITIKCKDTNLDPLPVKIGIIGGSGLDDPDILEQRQERVVETPYGEPSDALIEGEINGVQCVLLARHGRKHDIMPSNVNYRANIWALRDVGCTHLIVSTACGSLREEIKPGNLVVPHDFIDRTTKRLQTFYDGKAQSPRGVCHLPMFPAFSERTRNILLQAAKELEIPAHDKATIVTIEGPRFSSRSESHMFRQWGGDLINMTTCPEVVLAKEAGLLYGSVAIATDYDCWRMGCEGVNVQDVLRTFAENVIKVKKILVNAVGRIAKEDWSEDILNAKQCVCNNTMSGAM", "length": 289 }, "evidence": [ { "id": "Q3MHF7", "url": "https://omabrowser.org/oma/group/Q3MHF7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3MHF7", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3MHF7", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3MHF7", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "purine ribonucleoside salvage", "id": "GO:0006166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006166", "evidence": [ { "database": "UniProtKB", "id": "Q3MHF7", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7" } ], "pmid": "" }, { "name": "L-methionine salvage from methylthioadenosine", "id": "GO:0019509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019509", "evidence": [ { "database": "UniProtKB", "id": "Q3MHF7", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "S-methyl-5-thioadenosine phosphorylase activity", "id": "GO:0017061", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017061", "evidence": [ { "database": "UniProtKB", "id": "Q3MHF7", "url": "https://www.uniprot.org/uniprotkb/Q3MHF7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11852", "name": "", "equation": "S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHF7-1", "E1BM13-1", "A0A3Q1LUB3-1" ], "evidence": [ { "id": "11852", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11852" } ] }, { "id": "R-BTA-1237160", "name": "MTA is cleaved and phosphorylated", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-353106" ], "output_participant_list": [], "enzyme_list": [ "Q3MHF7-1" ], "evidence": [ { "id": "R-BTA-1237160", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1237160" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-353106", "participant_name": "MTAD [cytosol]", "crossref": [ { "id": "17509", "database": "ChEBI", "url": "" }, { "id": "C00170", "database": "COMPOUND", "url": "" }, { "id": "ZINC000004228245", "database": "ZINC", "url": "" }, { "id": "HMDB0001173", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LUB3", "gene_name": "MTAP", "activity": [ { "ec_number": "2.4.2.28", "activity": "S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine.", "evidence": [ { "id": "A0A3Q1LUB3", "database": "UniProtKB", "url": 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"MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPILKAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAARRTGRLRGTKTVQEKEN", "length": 257, "header": "sp|Q3T0S6-1|RL8_BOVIN Isoform 1 of Large ribosomal subunit protein uL2 OS=Bos taurus OX=9913 GN=RPL8 PE=1 SV=3 CANONICAL=Q3T0S6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZK2-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0S6/entry#A0AAA9SZK2-1", "sequence": { "sequence": "MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISSANRAVVGVVAGGGRIDKPILKAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAARRTGRLRGTKTVQEKEN", "length": 236, "header": "tr|A0AAA9SZK2-1|RL8_BOVIN Computationally mapped isoform of Large ribosomal subunit protein uL2 OS=Bos taurus OX=9913 GN=RPL8 PE=1 SV=1 CANONICAL=Q3T0S6-1" }, "locus": { 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"Ensembl Transcript", "id": "ENSBTAT00000037367.5", "url": "https://www.ensembl.org/id/ENSBTAT00000037367.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037200.3", "url": "https://www.ensembl.org/id/ENSBTAP00000037200.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Regulation of DNA methylation on EEF1D and RPL8 expression in cattle.", "journal": "Genetica", "date": "2017-10", "authors": "Liu Xuan, Yang Jie, Zhang Qin, Jiang Li", "evidence": [ { "database": "RefSeq", "id": "NP_001029797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029797" } ], "reference": [ { "type": "PubMed", "id": "28667419", "url": "https://glygen.org/publication/PubMed/28667419" } ] }, { "title": "A novel mutation in the promoter region of RPL8 regulates milk fat traits in dairy cattle by binding transcription factor Pax6.", "journal": "Biochimica et biophysica acta. 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As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2#function" }, { "database": "UniProtKB", "id": "P49368", "url": "https://www.uniprot.org/uniprotkb/P49368#function" }, { "database": "UniProtKB", "id": "A0AAA9T2H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2H6#function" }, { "database": "UniProtKB", "id": "ARBA00093360", "url": "https://www.uniprot.org/uniprotkb/ARBA00093360#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCT3", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2", "locus": { "chromosome": "3", "start_pos": 14501164, "end_pos": 14486292, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006370", "url": "https://www.ensembl.org/id/ENSBTAG00000006370" } ] } } ], "crossref": [ { "id": "Q3T0K2", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0K2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006370", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006370", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "3.6.4.B10", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.4.B10&UniProtAcc=Q3T0K2", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd03337", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03337", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504735", "url": "https://www.ncbi.nlm.nih.gov/gene/504735", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "3IYG", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=3IYG&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "4B2T", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=4B2T&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "Q3T0K2", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q3T0K2*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002194", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002194", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002423", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002423", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017998", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017998", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027410", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027410", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053374", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053374", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504735", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504735", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CGGSTIR", "url": "https://omabrowser.org/oma/group/CGGSTIR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0K2", "url": "https://www.orthodb.org/?gene=Q3T0K2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11353", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11353", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00003iyg", "url": "https://www.rcsb.org/structure/pdb_00003iyg", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00004b2t", "url": "https://www.rcsb.org/structure/pdb_00004b2t", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3IYG", "url": "https://www.rcsb.org/structure/3IYG", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4B2T", "url": "https://www.rcsb.org/structure/4B2T", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00118", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00118", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-390471", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390471", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5620922", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620922", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6814122", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814122", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001017934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017934", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T2H6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2H6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2H6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2H6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0K2-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKALDDMISTLKKISIPVDTSNRDTMLNIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREEDVGTGAGLLEIKKIGDEYFTFITECKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQSRQGGAPDAGQE", "length": 545, "header": "sp|Q3T0K2-1|TCPG_BOVIN Isoform 1 of T-complex protein 1 subunit gamma OS=Bos taurus OX=9913 GN=CCT3 PE=1 SV=1 CANONICAL=Q3T0K2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T2H6-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2/entry#A0AAA9T2H6-1", "sequence": { "sequence": "MMGHRPVLVLSQNTKRESGRKVQSGNINAAKIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKALDDMISTLKKISIPVDTSNRDTMLNIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREEDVGTGAGLLEIKKIGDEYFTFITECKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQSRQGGAPDAGQE", "length": 507, "header": "tr|A0AAA9T2H6-1|TCPG_BOVIN Computationally mapped isoform of T-complex protein 1 subunit gamma OS=Bos taurus OX=9913 GN=CCT3 PE=1 SV=1 CANONICAL=Q3T0K2-1" }, "locus": { "chromosome": "3", "start_pos": 14500933, "end_pos": 14486680, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133819.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133819.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089864.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089864.1" } ] } }, { "isoform_ac": "Q3T0K2-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2/entry#Q3T0K2-1", "sequence": { "sequence": "MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKALDDMISTLKKISIPVDTSNRDTMLNIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREEDVGTGAGLLEIKKIGDEYFTFITECKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQSRQGGAPDAGQE", "length": 545, "header": "sp|Q3T0K2-1|TCPG_BOVIN Isoform 1 of T-complex protein 1 subunit gamma OS=Bos taurus OX=9913 GN=CCT3 PE=1 SV=1 CANONICAL=Q3T0K2-1" }, "locus": { "chromosome": "3", "start_pos": 14500933, "end_pos": 14486680, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008358.8", "url": "https://www.ensembl.org/id/ENSBTAT00000008358.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008358.5", "url": "https://www.ensembl.org/id/ENSBTAP00000008358.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 11, "end_pos": 11, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "site_lbl": "Ser11" }, { "start_pos": 170, "end_pos": 170, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "site_lbl": "Ser170" }, { "start_pos": 243, "end_pos": 243, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "site_lbl": "Ser243" }, { "start_pos": 244, "end_pos": 244, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "site_lbl": "Ser244" }, { "start_pos": 247, "end_pos": 247, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "site_lbl": "Tyr247" }, { "start_pos": 252, "end_pos": 252, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "site_lbl": "Ser252" }, { "start_pos": 430, "end_pos": 430, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "site_lbl": "Thr430" }, { "start_pos": 459, "end_pos": 459, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "site_lbl": "Thr459" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:504735", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504735", "resource": "KEGG Pathway" }, { "id": "R-BTA-390471", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390471", "resource": "Reactome", "description": "Association of TriC/CCT with target proteins during biosynthesis" }, { "id": "R-BTA-5620922", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620922", "resource": "Reactome", "description": "BBSome-mediated cargo-targeting to cilium" }, { "id": "R-BTA-6814122", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814122", "resource": "Reactome", "description": "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2Q9C7-1", "protein_name": "T-complex protein 1 subunit gamma", "gene_name": "CCT3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMGHRPVLVLSQNTKRESGRKVQSGNINAAKIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKALDDMISTLKKISTPVDTNNRDMMLNIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIHLKPDVVITEKGISDLAQHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREEDIGTGAGLLEIKKIGDEYFTFITECKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQSRQGGAPDAGQE", "length": 507 }, "evidence": [ { "id": "Q3T0K2", "url": "https://omabrowser.org/oma/group/Q3T0K2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V1AJS6-1", "protein_name": "T-complex protein 1 subunit gamma", "gene_name": "CCT3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MMGPRPVLVLSQNVKRESGRKVQAGNITAAKTIADIIRTCLGPRAMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVIIGAYRKALDDMIHVLKKISTPVDVNNREMMLKIIKSAINTKAINRWSELACSIALDAVRTVELEENGRKEIDIKKYAKVEKIPGGFSEDSCVLRGIMVNKDVTHPRMRRLIKNPRIVLLDCSLEYKKGESQTDIEITREEDFARILQMEEEYIQQICEDLLRVKPDLVITEKGISDLAQHYLMRANISAVRRVRKTDNNRIARACGARIVSRTDELREEDVGTGAGLFEVKKIGDEYFAFITDCKEPKACTIVLRGASKEILAEVERNLQDAMQVCRNVLVDPQLVPGGGAAEMAVSHALTEKSKGMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRVLTSLRAKHTQEGSQTWGVNGESGALADMKELGVWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGEEHSKAPAPTEAAQE", "length": 545 }, "evidence": [ { "id": "Q3T0K2", "url": "https://omabrowser.org/oma/group/Q3T0K2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HG83-1", "protein_name": "T-complex protein 1 subunit gamma", "gene_name": "Cct3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVIGAYRMALDDMISTLKKISTPVDVNNRDMMLNIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITECKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQSRQSSAPDGGQE", "length": 545 }, "evidence": [ { "id": "Q3T0K2", "url": "https://omabrowser.org/oma/group/Q3T0K2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P39077-1", "protein_name": "T-complex protein 1 subunit gamma", "gene_name": "CCT3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE", "length": 534 }, "evidence": [ { "id": "Q3T0K2", "url": "https://omabrowser.org/oma/group/Q3T0K2/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P48605-1", "protein_name": "T-complex protein 1 subunit gamma", "gene_name": "CCT3", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFGGQQPILVLSQNTKRESGRKVQLENIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGNAILREITVQHPAAKSMIEIARTQDEEVGDGTTSVIVLAGEMLAAAEPFLQQQIHPTVIIRAYREALEDIVGHLQSQLSIQLDVKDKAKMADVVKACVGTKFIGKWSDLAVKIALDAVETVTLSENGRLEVDIKRYAKVEKIPGGAIEESCVLKGVMINKDVTHPKMRRLIENPRIVLLDCSLEYKKGESQTNVEIIGEQDFTRMLQIEEEFVQRICADIIAVKPDLVFTEKGVSDLAQHYLLKAGITAIRRLRKTDNLRIARACGATIVNRTEELTEKDVGTGAGLFEVKKIGDEYFTFVTECKEPKACTILLRGASKDILNETERNLQDALHVARNLVLEPRLVAGGGAVEMAASQLLTRKQVKGPYTAVAHALEIIPRTLAQNCGANTIRALTALRAKHASHTGDGVCAWGIDGESGEIVDMNVKNIWEPLAVKLQTYKTAVETAILLLRIDDIVSGSKKRGGNEPTNPAAMAQGQE", "length": 544 }, "evidence": [ { "id": "Q3T0K2", "url": "https://omabrowser.org/oma/group/Q3T0K2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P49368-1", "protein_name": "T-complex protein 1 subunit gamma", "gene_name": "CCT3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKALDDMISTLKKISIPVDISDSDMMLNIINSSITTKAISRWSSLACNIALDAVKMVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQSRQGGAPDAGQE", "length": 545 }, "evidence": [ { "id": "Q3T0K2", "url": "https://omabrowser.org/oma/group/Q3T0K2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P80318-1", "protein_name": "T-complex protein 1 subunit gamma", "gene_name": "Cct3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRMALDDMISTLKKISTPVDVNNREMMLSIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIHQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQESCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQNRQTGAPDAGQE", "length": 545 }, "evidence": [ { "id": "Q3T0K2", "url": "https://omabrowser.org/oma/group/Q3T0K2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54TH8-1", "protein_name": "T-complex protein 1 subunit gamma", "gene_name": "cct3", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNQPVFVLNTNAKRENQKEAQQGIFLAVKSVASIIKTCLGPKAMLKMILDPMGTTVVTNDGNAILREIDVTHPAAKSMIELSRAQDENVGDGTTSVVILAAEVLASSELFIEKKIHPHYIIKAFRMALDDSLSIVDQYSVAIDLKNRPEVLKVVQSCIGTKFIGKWGSLMCNLALDAVMTVHIQEEDGRSEIDIKRYAKVEKIPGGDISDCRVIRGVMLNKDVTHPKMKRMIKNPRIVLLDCSLEYKKGESDTMVDITNEDDFSALLKIEEEYVQRICEDIIKLKPDLVFTEKGVSDLAQHFFVKKGITCLRRLKKSENNRIARISGATIVSRTDELQESDIGTGCGLFEIRKIGDEYFTFLEDCKEPKACTILLRGASKDILNEVERNLTDALNVARNIVLDPRLVPGGGAIEMALSQALSEKSKSIEGLHQLPYKALAQSLECIPKILAQNCGANTVKLLTELRAKHATNPTENYTYGVDGDNGTIVDMKQLGIWDTHSVKVQTLKTAIESACTMLRVDHIASAASKQ", "length": 530 }, "evidence": [ { "id": "Q3T0K2", "url": "https://omabrowser.org/oma/group/Q3T0K2/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6P502-1", "protein_name": "T-complex protein 1 subunit gamma", "gene_name": "Cct3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRMALDDMVSTLKKISTPVDVNNRDMMLNIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQNRQTGAPDAGQE", "length": 545 }, "evidence": [ { "id": "Q3T0K2", "url": "https://omabrowser.org/oma/group/Q3T0K2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q84WV1-1", "protein_name": "T-complex protein 1 subunit gamma", "gene_name": "CCT3", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MHAPVLVLSDSLKRESGSKVHHGNIQASKAVADIIRTTLGPRSMLKMLLDAGGGIVVTNDGNAILRELDVAHPAAKSMIELSRTQDEEVGDGTTSVIVLAGEMLHVAEAFLEKNYHPTVICRAYIKALEDSIAVLDKIAMSIDINDRSQVLGLVKSCIGTKFTSQFGDLIADLAIDATTTVGVDLGQGLREVDIKKYIKVEKVPGGQFEDSEVLKGVMFNKDVVAPGKMKRKIVNPRIILLDCPLEYKKGENQTNAELVREEDWEVLLKLEEEYIENICVQILKFKPDLVITEKGLSDLACHYFSKAGVSAIRRLRKTDNNRIAKACGAVIVNRPDELQESDIGTGAGLFEVKKIGDDFFSFIVDCKEPKACTVLLRGPSKDFINEVERNLQDAMSVARNIIKNPKLVPGGGATELTVSATLKQKSATIEGIEKWPYEAAAIAFEAIPRTLAQNCGVNVIRTMTALQGKHANGENAWTGIDGNTGAIADMKESKIWDSYNVKAQTFKTAIEAACMLLRIDDIVSGIKKKQAPGSGPSKPTIETEGDADNEQILPD", "length": 555 }, "evidence": [ { "id": "Q3T0K2", "url": "https://omabrowser.org/oma/group/Q3T0K2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "pmid": "" }, { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "pmid": "" }, { "name": "ATP-dependent protein folding chaperone", "id": "GO:0140662", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140662", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "pmid": "" }, { "name": "cell body", "id": "GO:0044297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044297", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "pmid": "" }, { "name": "chaperonin-containing T-complex", "id": "GO:0005832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005832", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "pmid": "" }, { "name": "zona pellucida receptor complex", "id": "GO:0002199", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002199", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "pmid": "" }, { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K2", "url": "https://www.uniprot.org/uniprotkb/Q3T0K2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] }, { "id": "R-BTA-391266", "name": "Association of CCT/TriC with sphingosine kinase 1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-391266", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-391266" } ] }, { "id": "R-BTA-5624125", "name": "Formation of the BBSome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBH0-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-5624125", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5624125" } ] }, { "id": "R-BTA-6814119", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6814119", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814119" } ] }, { "id": "R-BTA-6814120", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6814120", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814120" } ] }, { "id": "R-BTA-6814121", "name": "PDCL binds G-protein beta and TRiC/CCT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6814121", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814121" } ] }, { "id": "R-BTA-6814124", "name": "ATP binds G-protein beta associated TRiC/CCT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6814124", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814124" } ] }, { "id": "R-BTA-8850527", "name": "PDCL releases folded G-beta from TRiC/CCT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-8850527", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8850527" } ] }, { "id": "R-BTA-8850529", "name": "RGS proteins bind GNB5 and CCT/TRiC", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-8850529", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8850529" } ] }, { "id": "R-BTA-8850534", "name": "PDCL promotes G-protein beta 5 folding", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-8850534", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8850534" } ] }, { "id": "R-BTA-8850539", "name": "Release of GNB5:RGS dimers from CCT/TRiC", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-8850539", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8850539" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": 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"ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": 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"https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] } ] }, { "uniprot_ac": "A0AAA9TT27", 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"5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { 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ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": 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RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", 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"evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TBP1", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] } ] }, { 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Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. 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"chromosome": "13", "start_pos": 55059789, "end_pos": 55054324, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097355.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097355.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093123.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093123.1" } ] } }, { "isoform_ac": "A0ABI0NL42-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG0/entry#A0ABI0NL42-1", "sequence": { "sequence": "MVAWGAHGSWDWGAAARKERRGRRSRGPAGRLSGSRLPRTGERGFWCLDKGSAGCGLRFPAPCPEPSARLPPTPSWRGPRAGLGGLGRCEGAELKRQSSALASFRALLEGVGGWGGRSLDSSQVGVRGKDIVVLGVEKKSVAKLQDERTVRKICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQPLKILNPEEIEKYVAEIEKEKEENEKKKQKKAS", "length": 339, "header": "tr|A0ABI0NL42-1|A0ABI0NL42_BOVIN Computationally mapped isoform of Proteasome 20S subunit alpha 7 OS=Bos taurus OX=9913 GN=PSMA7 PE=1 SV=1 CANONICAL=Q3ZBG0-1" }, "locus": { "chromosome": "13", "start_pos": 55059789, "end_pos": 55054669, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151736.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151736.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105657.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105657.1" } ] } }, { "isoform_ac": "Q3ZBG0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG0/entry#Q3ZBG0-1", "sequence": { "sequence": "MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGKDIVVLGVEKKSVAKLQDERTVRKICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQPLKILNPEEIEKYVAEIEKEKEENEKKKQKKAS", "length": 248, "header": "sp|Q3ZBG0-1|PSA7_BOVIN Isoform 1 of Proteasome subunit alpha type-7 OS=Bos taurus OX=9913 GN=PSMA7 PE=1 SV=1 CANONICAL=Q3ZBG0-1" }, "locus": { "chromosome": "13", "start_pos": 55059789, "end_pos": 55054442, "strand": 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[ { "database": "UniProtKB", "id": "Q3ZBG0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG0" } ], "site_lbl": "Tyr153" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The structure of the mammalian 20S proteasome at 2.75 A resolution.", "journal": "Structure", "date": "2002", "authors": "Unno Masaki, Mizushima Tsunehiro, Morimoto Yukio, Tomisugi Yoshikazu, Tanaka Keiji, Yasuoka Noritake, Tsukihara Tomitake", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG0" } ], "reference": [ { "type": "PubMed", "id": "12015144", "url": "https://glygen.org/publication/PubMed/12015144" } ] } ], "pathway": [ { "id": "bta:505050", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505050", "resource": "KEGG Pathway" }, { "id": "R-BTA-1169091", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1169091", "resource": "Reactome", "description": "Activation of 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"glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A287AT18-1", "protein_name": "Proteasome subunit alpha type", "gene_name": "PSMA7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVARLQDERTVRKICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEAIETDGLTIKLVIKALLEVVQSGGKNIELAVMRRDQPLKILNPEEIEKYVAEIEKEKEENEKKKQKKAS", "length": 248 }, "evidence": [ { "id": "Q3ZBG0", "url": "https://omabrowser.org/oma/group/Q3ZBG0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O14818-1", "protein_name": "Proteasome subunit alpha type-7", "gene_name": "PSMA7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVRKICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEENEKKKQKKAS", "length": 248 }, "evidence": [ { "id": "Q3ZBG0", "url": "https://omabrowser.org/oma/group/Q3ZBG0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O24616-1", "protein_name": "Proteasome subunit alpha type-7-B", "gene_name": "PAD2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MARYDRAITVFSPDGHLFQVEYALEAVRKGNAAVGVRGTDTVVLAVEKKSTPKLQDSRSARKIVSLDNHIALACAGLKADARVLINKARIECQSHRLTLEDPVTVEYITRYIAGLQQKYTQSGGVRPFGLSTLIVGFDPYSRLPSLYQTDPSGTFSAWKANATGRNSNSIREFLEKNYKESSGQETIKLAIRALLEVVESGGKNIEVAVMTREETGLRQLEEAEIDAIVAKIEAEKAAAEAAKKGPPKET", "length": 250 }, "evidence": [ { "id": "Q3ZBG0", "url": "https://omabrowser.org/oma/group/Q3ZBG0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P22769-1", "protein_name": "Proteasome subunit alpha type-7-1", "gene_name": "Prosalpha4", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSSRYDRAVTIFSPDGHLLQVEYAQEAVRKGSTAVGVRGANCVVLGVEKKSVAQLQEDRKVRKICMLDNHVVMAFAGLTADARIMINRAQVECQSHRLNVEDPVTLEYITRFIAQLKQKYTQSNGRRPFGISCLIGGFDADGSAHLFQTEPSGIFYEYKANATGRSAKVVREFFEKSYREEEVANEHGAVKLAIRALLEVAQSGQNNLEVAIMENGKPLKMLDTDVITDYVKIIEKEKEEELEKKKQKK", "length": 249 }, "evidence": [ { "id": "Q3ZBG0", "url": "https://omabrowser.org/oma/group/Q3ZBG0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P34120-1", "protein_name": "Proteasome subunit alpha type-7", "gene_name": "psmA7", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSSARYDRAITVFSPDGHLFQVEYAMEAVRKGTVAVGVRGKDVIVLGVEKKATAKLQDARSIRKIVKLDDHICLTFAGLTADSRVLISKALMECQSYRLTVEDSPSVEYISKFIAGIQQRYTQSGGVRPFGISTLIVGFDTDGTPNLYQTDPSGSYSSWKAAAIGRSSKSVGEFLEKNYTDVSEEESIKLAVRALLEIVESGNKNIEIAVIRNKQPIVLLDEQEIDKLVAVVEAEKEIQKEQEKSEKQQK", "length": 250 }, "evidence": [ { "id": "Q3ZBG0", "url": "https://omabrowser.org/oma/group/Q3ZBG0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "P40303-1", "protein_name": "Proteasome subunit alpha type-4", "gene_name": "PRE6", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSGYDRALSIFSPDGHIFQVEYALEAVKRGTCAVGVKGKNCVVLGCERRSTLKLQDTRITPSKVSKIDSHVVLSFSGLNADSRILIEKARVEAQSHRLTLEDPVTVEYLTRYVAGVQQRYTQSGGVRPFGVSTLIAGFDPRDDEPKLYQTEPSGIYSSWSAQTIGRNSKTVREFLEKNYDRKEPPATVEECVKLTVRSLLEVVQTGAKNIEITVVKPDSDIVALSSEEINQYVTQIEQEKQEQQEQDKKKKSNH", "length": 254 }, "evidence": [ { "id": "Q3ZBG0", "url": 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"kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3T094-1", "uniprot_ac": "Q3T094", "uniprot_id": "ETHE1_BOVIN", "mass": { "chemical_mass": 27900.0, "monoisotopic_mass": 27900.0 }, "refseq": { "ac": "NP_001029516", "name": "persulfide dioxygenase ETHE1, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029516" }, 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"type": "synonym", "evidence": [ { "id": "NP_001029516", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029516" } ] }, { "name": "persulfide dioxygenase ETHE1, mitochondrial precursor", "type": "synonym", "evidence": [ { "id": "NP_001029516", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029516" } ] }, { "name": "persulfide dioxygenase ETHE1, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001029516", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029516" } ] }, { "name": "protein ETHE1, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001029516", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029516" } ] }, { "name": "sulfur dioxygenase ETHE1", "type": "synonym", "evidence": [ { "id": "NP_001029516", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029516" } ] } ], "function": [ { "annotation": "Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus.", "evidence": [ { "database": "UniProtKB", "id": "Q3T094", "url": "https://www.uniprot.org/uniprotkb/Q3T094#function" }, { "database": "UniProtKB", "id": "O95571", "url": "https://www.uniprot.org/uniprotkb/O95571#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T094", "url": "https://www.uniprot.org/uniprotkb/Q3T094" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ETHE1", "url": "https://www.uniprot.org/uniprotkb/Q3T094", "locus": { "chromosome": "18", "start_pos": 51712255, "end_pos": 51736995, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004379", "url": "https://www.ensembl.org/id/ENSBTAG00000004379" } ] } } ], "crossref": [ { "id": "Q3T094", "url": "https://alphafold.ebi.ac.uk/entry/Q3T094", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004379", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004379", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07724", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07724", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509150", "url": "https://www.ncbi.nlm.nih.gov/gene/509150", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001279", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001279", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036866", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036866", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044528", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044528", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051682", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051682", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509150", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509150", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VMDIDYA", "url": "https://omabrowser.org/oma/group/VMDIDYA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T094", "url": "https://www.orthodb.org/?gene=Q3T094", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43084", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43084", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43084:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43084:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00753", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00753", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1614517", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1614517", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029516", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "12981", "url": "https://www.rhea-db.org/rhea/12981", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T7B2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7B2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7B2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7B2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYW1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYW1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T094", "url": "https://www.uniprot.org/uniprotkb/Q3T094", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T094-1", "url": "https://www.uniprot.org/uniprotkb/Q3T094-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGSVLKIAGRRLSQHTGSGAPVLLRQMFEPKSCTYTYLLGDRESREAVLIDPVLETAQRDAQLVKELGLRLLYAVNTHCHADHITGSGLLRSLLPGCQSVISRLSGAQADWHIEDGDSIQFGRFALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAETLYHSVHEKIFTLPGNCLIYPAHDYHGLTVSTVEEERTLNPRLTLSCEEFVKVMDKLNLPKPQQIDFAVPANMRCGIQTPPS", "length": 254, "header": "sp|Q3T094-1|ETHE1_BOVIN Isoform 1 of Persulfide dioxygenase ETHE1, mitochondrial OS=Bos taurus OX=9913 GN=ETHE1 PE=2 SV=1 CANONICAL=Q3T094-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T7B2-1", "url": "https://www.uniprot.org/uniprotkb/Q3T094/entry#A0AAA9T7B2-1", "sequence": { "sequence": "MQPLRNLCIRTPMGPSPGTVACRPHSTSRDPGAWVRTPAPSPEDGPSLGAGLRAPPSAAVATAELPSDAGELHHPARAQRREGKGGSARELLGPASFPSPPPTPRRWGRQFACAVAARGGCCGGDGKEGVGGFSRPASWRAGAQLQAEGPEESVLRLAGPTVAGWGQALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAETLYHSVHEKIFTLPGNCLIYPAHDYHGLTVSTVEEERTLNPRLTLSCEEFVKVMDKLNLPKPQQIDFAVPANMRCGIQTPPS", "length": 296, "header": "tr|A0AAA9T7B2-1|ETHE1_BOVIN Computationally mapped isoform of Persulfide dioxygenase ETHE1, mitochondrial OS=Bos taurus OX=9913 GN=ETHE1 PE=2 SV=1 CANONICAL=Q3T094-1" }, "locus": { "chromosome": "18", "start_pos": 51736796, "end_pos": 51712416, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100542.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100542.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092635.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092635.1" } ] } }, { "isoform_ac": "A0AAA9TYW1-1", "url": "https://www.uniprot.org/uniprotkb/Q3T094/entry#A0AAA9TYW1-1", "sequence": { "sequence": "MAGSVLKIAGRRLSQHTGSGAPVLLRQMFEPKSCTYTYLLGDRESREAVLIDPVLETAQRDAQLVKELGLRLLYAVNTHCHADHITGSGLLRSLLPGCQSVISRLSGAQADWHIEDGDSIQFGRFALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAETLYHSVHEKIFTLPGNCLIYPAHDYHGLTVSTVEEERTLNPRLTLSCEEFVKVMDKLNLPKPQQIGEWLRIWTPGSEGGAGGLDTWV", "length": 259, "header": "tr|A0AAA9TYW1-1|ETHE1_BOVIN Computationally mapped isoform of Persulfide dioxygenase ETHE1, mitochondrial OS=Bos taurus OX=9913 GN=ETHE1 PE=2 SV=1 CANONICAL=Q3T094-1" }, "locus": { "chromosome": "18", "start_pos": 51729501, "end_pos": 51712610, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119158.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119158.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101899.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101899.1" } ] } }, { "isoform_ac": "Q3T094-1", "url": "https://www.uniprot.org/uniprotkb/Q3T094/entry#Q3T094-1", "sequence": { "sequence": "MAGSVLKIAGRRLSQHTGSGAPVLLRQMFEPKSCTYTYLLGDRESREAVLIDPVLETAQRDAQLVKELGLRLLYAVNTHCHADHITGSGLLRSLLPGCQSVISRLSGAQADWHIEDGDSIQFGRFALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAETLYHSVHEKIFTLPGNCLIYPAHDYHGLTVSTVEEERTLNPRLTLSCEEFVKVMDKLNLPKPQQIDFAVPANMRCGIQTPPS", "length": 254, "header": "sp|Q3T094-1|ETHE1_BOVIN Isoform 1 of Persulfide dioxygenase ETHE1, mitochondrial OS=Bos taurus OX=9913 GN=ETHE1 PE=2 SV=1 CANONICAL=Q3T094-1" }, "locus": { "chromosome": "18", "start_pos": 51729501, "end_pos": 51712416, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005747.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005747.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005747.4", "url": "https://www.ensembl.org/id/ENSBTAP00000005747.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 14, "end_pos": 14, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T094", "url": "https://www.uniprot.org/uniprotkb/Q3T094" } ], "site_lbl": "Ser14" }, { "start_pos": 19, "end_pos": 19, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T094", "url": "https://www.uniprot.org/uniprotkb/Q3T094" } ], "site_lbl": "Ser19" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:509150", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509150", "resource": "KEGG Pathway" }, { "id": "R-BTA-1614517", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1614517", "resource": "Reactome", "description": "Sulfide oxidation to sulfate" } ], "orthologs": [ { "uniprot_canonical_ac": "O95571-1", "protein_name": "Persulfide dioxygenase ETHE1, mitochondrial", "gene_name": "ETHE1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAVNTHCHADHITGSGLLRSLLPGCQSVISRLSGAQADLHIEDGDSIRFGRFALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTLPGDCLIYPAHDYHGFTVSTVEEERTLNPRLTLSCEEFVKIMGNLNLPKPQQIDFAVPANMRCGVQTPTA", "length": 254 }, "evidence": [ { "id": "Q3T094", "url": "https://omabrowser.org/oma/group/Q3T094/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9C8L4-1", "protein_name": "Persulfide dioxygenase ETHE1 homolog, mitochondrial", "gene_name": "GLY3", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVMTHFSRLRQLLLLQPKFLSSQPRPLRSPPPTFLRSVMGSSSSFSSSSSKLLFRQLFENESSTFTYLLADVSHPDKPALLIDPVDKTVDRDLKLIDELGLKLIYAMNTHVHADHVTGTGLLKTKLPGVKSVISKASGSKADLFLEPGDKVSIGDIYLEVRATPGHTAGCVTYVTGEGADQPQPRMAFTGDAVLIRGCGRTDFQEGSSDQLYESVHSQIFTLPKDTLIYPAHDYKGFEVSTVGEEMQHNPRLTKDKETFKTIMSNLNLSYPKMIDVAVPANMVCGLQDVPSQAN", "length": 294 }, "evidence": [ { "id": "Q3T094", "url": "https://omabrowser.org/oma/group/Q3T094/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9DCM0-1", "protein_name": "Persulfide dioxygenase ETHE1, mitochondrial", "gene_name": "Ethe1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASAVVRVAGRRLSQQSASGAPVLLRQMFEPKSCTYTYLLGDRESREAVLIDPVLETAHRDAQLIKELGLKLLYAVNTHCHADHITGTGVLRSLLPGCQSVISRLSGAQADLHIGEGDSIRFGRFALETRASPGHTPGCVTFVLNDQSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTLPGNCLIYPAHDYHGLTVSTVEEERTLNPRLTLSCEEFIKVMDNLNLPKPQQIDIAVPANMRCGVQTPPS", "length": 254 }, "evidence": [ { "id": "Q3T094", "url": "https://omabrowser.org/oma/group/Q3T094/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "Q3T094", "url": "https://www.uniprot.org/uniprotkb/Q3T094" } ], "pmid": "" }, { "name": "sulfur dioxygenase activity", "id": "GO:0050313", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050313", "evidence": [ { "database": "UniProtKB", "id": "Q3T094", "url": "https://www.uniprot.org/uniprotkb/Q3T094" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3T094", "url": "https://www.uniprot.org/uniprotkb/Q3T094" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3T094", "url": "https://www.uniprot.org/uniprotkb/Q3T094" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3T094", "url": "https://www.uniprot.org/uniprotkb/Q3T094" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q3T094", "url": "https://www.uniprot.org/uniprotkb/Q3T094" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "hydrogen sulfide metabolic process", "id": "GO:0070813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070813", "evidence": [ { "database": "UniProtKB", "id": "Q3T094", "url": "https://www.uniprot.org/uniprotkb/Q3T094" } ], "pmid": "" }, { "name": "glutathione metabolic process", "id": "GO:0006749", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006749", "evidence": [ { "database": "UniProtKB", "id": "Q3T094", "url": "https://www.uniprot.org/uniprotkb/Q3T094" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12981", "name": "", "equation": "S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3T094-1" ], "evidence": [ { "id": "12981", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12981" } ] }, { "id": "R-BTA-1614605", "name": "Persulfide sulfur is dioxygenated", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane, mitochondrial matrix", "input_participant_list": [ "R-BTA-1614576" ], "output_participant_list": [ "R-BTA-1614646" ], "enzyme_list": [ "F1MKF8-1", "Q3T094-1" ], "evidence": [ { "id": "R-BTA-1614605", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1614605" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-1614576", "participant_name": "SQOR [mitochondrial inner membrane]", "crossref": [ { "id": "F1MKF8", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000010365", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000013690", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000013690", "database": "ENSEMBL", "url": "" }, { "id": "XP_015328667.1", "database": "RefSeq", "url": "" }, { "id": "XP_015328668.1", "database": "RefSeq", "url": "" }, { "id": "XP_024853137.1", "database": "RefSeq", "url": "" }, { "id": "101453", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-1614646", "participant_name": "SQOR [mitochondrial inner membrane]", "crossref": [ { "id": "XP_024853137.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAP00000013690", "database": "ENSEMBL", "url": "" }, { "id": "XP_015328667.1", "database": "RefSeq", "url": "" }, { "id": "F1MKF8", "database": "UniProt", "url": "" }, { "id": "XP_015328668.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAG00000010365", "database": "ENSEMBL", "url": "" }, { "id": "101453", "database": "VGNC", "url": "" }, { "id": "ENSBTAT00000013690", "database": "ENSEMBL", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "F1MKF8", "gene_name": "SQOR", "activity": [ { "ec_number": "1.8.5.8", "activity": "a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol.", "evidence": [ { "id": "F1MKF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKF8" } ] }, { "ec_number": "1.8.5.8", "activity": "", "evidence": [ { "id": "F1MKF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKF8" } ] } ] }, { "uniprot_ac": "Q3T094", "gene_name": "ETHE1", "activity": [ { "ec_number": "1.13.11.18", "activity": "S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+).", "evidence": [ { "id": "Q3T094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T094" } ] }, { "ec_number": "1.13.11.18", "activity": "", "evidence": [ { "id": "Q3T094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T094" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T094-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 254, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T094-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T094" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q3T094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T094#function" }, { "id": "Q3T094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T094" } ], "binding_site_uniprot": 135, "amino_acid": "His", "chebi_lig_id": "CHEBI_24875", "ligand": "Fe cation", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000250", "start_pos": 135, "end_pos": 135, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T094#function" }, { "id": "Q3T094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T094" } ], "binding_site_uniprot": 154, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_24875", "ligand": "Fe cation", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000250", "start_pos": 154, "end_pos": 154, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T094#function" }, { "id": "Q3T094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T094" } ], "binding_site_uniprot": 79, "amino_acid": "His", "chebi_lig_id": "CHEBI_24875", "ligand": "Fe cation", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000250", "start_pos": 79, "end_pos": 79, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.13.11.18", "ec_name": "S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+).", "evidence": [ { "id": "1.13.11.18", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.18" }, { "id": "1.13.11.18", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.13.11.18" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 14, 19 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0V3-1", "uniprot_ac": "Q3T0V3", "uniprot_id": "EIF3K_BOVIN", "mass": { "chemical_mass": 25074.0, "monoisotopic_mass": 25074.0 }, "refseq": { "ac": "NP_001029661", "name": "eukaryotic translation initiation factor 3 subunit K", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029661" }, "gene_names": [ { "name": "EIF3K", "type": "recommended", "evidence": [ { "id": "Q3T0V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3" } ] }, { "name": "EIF3K", "type": "synonym", "evidence": [ { "id": "NP_001029661", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029661" } ] }, { "name": "EIF3S12", "type": "synonym", "evidence": [ { "id": "Q3T0V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3" } ] } ], "protein_names": [ { "name": "Eukaryotic translation initiation factor 3 subunit K", "type": "recommended", "evidence": [ { "id": "Q3T0V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3/entry#names_and_taxonomy" } ] }, { "name": "Eukaryotic translation initiation factor 3 subunit 12", "type": "synonym", "evidence": [ { "id": "Q3T0V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3/entry#names_and_taxonomy" } ] }, { "name": "eIF-3 p25", "type": "synonym", "evidence": [ { "id": "NP_001029661", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029661" }, { "id": "Q3T0V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3/entry#names_and_taxonomy" } ] }, { "name": "eIF3k", "type": "synonym", "evidence": [ { "id": "Q3T0V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3/entry#names_and_taxonomy" } ] }, { "name": "eukaryotic translation initiation factor 3 subunit 12", "type": "synonym", "evidence": [ { "id": "NP_001029661", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029661" } ] }, { "name": "eukaryotic translation initiation factor 3 subunit K", "type": "synonym", "evidence": [ { "id": "NP_001029661", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029661" } ] } ], "function": [ { "annotation": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. 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{ "id": "A0AAA9T7E8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9V4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9V4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9V4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9V4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0V3", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0V3-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDLEANLAVLKLYQFNPAFFQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQALDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLAEMLGDLTDSQLKVWMSKYGWSADESGQIFICSQEESIKPKNIVEKIDFDSVSSIMASSQ", "length": 218, "header": "sp|Q3T0V3-1|EIF3K_BOVIN Isoform 1 of Eukaryotic translation initiation factor 3 subunit K OS=Bos taurus OX=9913 GN=EIF3K PE=2 SV=1 CANONICAL=Q3T0V3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T7E8-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3/entry#A0AAA9T7E8-1", "sequence": { "sequence": "MAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDLEANLAVLKLYQFNPAFFQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQALDENMDLLEGITGFEDSVRKYSQLKVWMSKYGWSADESGQIFICSQEESIKPKNIVEKIDFDSVSSIMASSQ", "length": 192, "header": "tr|A0AAA9T7E8-1|EIF3K_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 3 subunit K OS=Bos taurus OX=9913 GN=EIF3K PE=2 SV=1 CANONICAL=Q3T0V3-1" }, "locus": { "chromosome": "18", "start_pos": 48396099, "end_pos": 48383321, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105003.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105003.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092682.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092682.1" } ] } }, { "isoform_ac": "A0AAA9T9V4-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3/entry#A0AAA9T9V4-1", "sequence": { "sequence": "MAMFEQMRANVGKLLKGIDRYQFNPAFFQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQALDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLAEMLGDLTDSQLKVWMSKYGWSADESGQIFICSQEESIKPKNIVEKIDFDSVSSIMASSQ", "length": 185, "header": "tr|A0AAA9T9V4-1|EIF3K_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 3 subunit K OS=Bos taurus OX=9913 GN=EIF3K PE=2 SV=1 CANONICAL=Q3T0V3-1" }, "locus": { "chromosome": "18", "start_pos": 48396099, "end_pos": 48383321, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114645.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114645.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092700.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092700.1" } ] } }, { "isoform_ac": "Q3T0V3-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3/entry#Q3T0V3-1", "sequence": { "sequence": "MAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDLEANLAVLKLYQFNPAFFQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQALDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLAEMLGDLTDSQLKVWMSKYGWSADESGQIFICSQEESIKPKNIVEKIDFDSVSSIMASSQ", "length": 218, "header": "sp|Q3T0V3-1|EIF3K_BOVIN Isoform 1 of Eukaryotic translation initiation factor 3 subunit K OS=Bos taurus OX=9913 GN=EIF3K PE=2 SV=1 CANONICAL=Q3T0V3-1" }, "locus": { "chromosome": "18", "start_pos": 48396099, "end_pos": 48383321, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014888.5", "url": "https://www.ensembl.org/id/ENSBTAT00000014888.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014888.3", "url": "https://www.ensembl.org/id/ENSBTAP00000014888.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 217, "end_pos": 217, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0V3", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3" } ], "site_lbl": "Ser217" }, { "start_pos": 28, "end_pos": 28, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0V3", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3" } ], "site_lbl": "Thr28" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515326", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515326", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-72649", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "resource": "Reactome", "description": "Translation initiation complex formation" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "resource": "Reactome", "description": "Formation of the ternary complex, and subsequently, the 43S complex" }, { "id": "R-BTA-72702", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "resource": "Reactome", "description": "Ribosomal scanning and start codon recognition" } ], "orthologs": [ { "uniprot_canonical_ac": "Q54EQ1-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit K", "gene_name": "eif3K", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MENDQDQQQQQQQSQQQQPQQEEQEQVDVDLSSLQGQERIEYINTLIADSYNIAIAKKLEEFLDIQINENTYLFQANSTLLKLYQFNPTHLNKDSIAKMLAKALMNFPCNDFLFLSYMIPSIIQKEEPLLKLFILNNFLETCKFKEAWTHINSHSFFSEIPSFIDNIRNFISGVLSITYQNISITMLGELLNLSDRTQLVDYIQSKQPTWKISDSTVSLQSDNSKQKKADTFTFDQLSRILPTFIK", "length": 246 }, "evidence": [ { "id": "Q3T0V3", "url": "https://omabrowser.org/oma/group/Q3T0V3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9DBZ5-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit K", "gene_name": "Eif3k", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDLEANLAVLKLYQFNPAFFQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQALDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLAEMLGDLTDNQLKVWMSKYGWSADESGQVFICSQEESIKPKNIVEKIDFDSVSSIMASSQ", "length": 218 }, "evidence": [ { "id": "Q3T0V3", "url": "https://omabrowser.org/oma/group/Q3T0V3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9SZA3-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit K", "gene_name": "TIF3K1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGVEIQSPQEQSSYTVEQLVALNPFNPEILPDLENYVNVTSQTYSLEVNLCLLRLYQFEPERMNTHIVARILVKALMAMPTPDFSLCLFLIPERVQMEEQFKSLIVLSHYLETGRFQQFWDEAAKNRHILEAVPGFEQAIQAYASHLLSLSYQKVPRSVLAEAVNMDGASLDKFIEQQVTNSGWIVEKEGGSIVLPQNEFNHPELKKNTGENVPLEHIARIFPILG", "length": 226 }, "evidence": [ { "id": "Q3T0V3", "url": "https://omabrowser.org/oma/group/Q3T0V3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9UBQ5-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit K", "gene_name": "EIF3K", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDLEANLAVLKLYQFNPAFFQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQALDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLAEMLGDLSDSQLKVWMSKYGWSADESGQIFICSQEESIKPKNIVEKIDFDSVSSIMASSQ", "length": 218 }, "evidence": [ { "id": "Q3T0V3", "url": "https://omabrowser.org/oma/group/Q3T0V3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q3T0V3", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3" } ], "pmid": "" }, { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "Q3T0V3", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3" } ], "pmid": "" }, { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "Q3T0V3", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3T0V3", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3T0V3", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3" } ], "pmid": "" }, { "name": "eukaryotic 43S preinitiation complex", "id": "GO:0016282", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016282", "evidence": [ { "database": "UniProtKB", "id": "Q3T0V3", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3" } ], "pmid": "" }, { "name": "eukaryotic 48S preinitiation complex", "id": "GO:0033290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033290", "evidence": [ { "database": "UniProtKB", "id": "Q3T0V3", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3" } ], "pmid": "" }, { "name": "eukaryotic translation initiation factor 3 complex", "id": "GO:0005852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005852", "evidence": [ { "database": "UniProtKB", "id": "Q3T0V3", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "translational initiation", "id": "GO:0006413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006413", "evidence": [ { "database": "UniProtKB", "id": "Q3T0V3", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3" } ], "pmid": "" }, { "name": "regulation of translational initiation", "id": "GO:0006446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006446", "evidence": [ { "database": "UniProtKB", "id": "Q3T0V3", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3" } ], "pmid": "" }, { "name": "formation of cytoplasmic translation initiation complex", "id": "GO:0001732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001732", "evidence": [ { "database": "UniProtKB", "id": "Q3T0V3", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0V3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 218, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0V3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0V3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3T0V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0V3" }, { "id": "PRU01185", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01185" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PCI", "eco_id": "ECO_0000255", "start_pos": 42, "end_pos": 204, "start_aa": "Tyr", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 28, 217 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHW9-1", "uniprot_ac": "Q3MHW9", "uniprot_id": "NB5R1_BOVIN", "mass": { "chemical_mass": 33861.0, "monoisotopic_mass": 33861.0 }, "refseq": { "ac": "NP_001029690", "name": "NADH-cytochrome b5 reductase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029690" }, "gene_names": [ { "name": "CYB5R1", "type": "recommended", "evidence": [ { "id": "Q3MHW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9" } ] }, { "name": "CYB5R1", "type": "synonym", "evidence": [ { "id": "NP_001029690", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029690" } ] } ], "protein_names": [ { "name": "NADH-cytochrome b5 reductase 1", "type": "recommended", "evidence": [ { "id": "Q3MHW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9/entry#names_and_taxonomy" } ] }, { "name": "1.6.2.2", "type": "synonym", "evidence": [ { "id": "Q3MHW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9/entry#names_and_taxonomy" } ] }, { "name": "NADH-cytochrome b5 reductase 1", "type": "synonym", "evidence": [ { "id": "NP_001029690", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029690" } ] }, { "name": "b5R.1", "type": "synonym", "evidence": [ { "id": "NP_001029690", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029690" }, { "id": "Q3MHW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor.", "evidence": [ { "database": "UniProtKB", "id": "Q3MHW9", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9#function" }, { "database": "UniProtKB", "id": "P00387", "url": "https://www.uniprot.org/uniprotkb/P00387#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHW9", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CYB5R1", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9", "locus": { "chromosome": "16", "start_pos": 79870576, "end_pos": 79860466, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019927", "url": "https://www.ensembl.org/id/ENSBTAG00000019927" } ] } } ], "crossref": [ { "id": "Q3MHW9", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHW9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019927", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019927", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06183", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06183", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "516287", "url": "https://www.ncbi.nlm.nih.gov/gene/516287", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001709", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001834", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001834", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017927", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017927", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039261", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039261", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516287", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516287", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CLDPENW", "url": "https://omabrowser.org/oma/group/CLDPENW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3MHW9", "url": "https://www.orthodb.org/?gene=Q3MHW9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19370", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19370", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19370:SF74", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19370:SF74", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00175", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00175", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00970", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00970", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-114608", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1237044", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1237044", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029690", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "46680", "url": "https://www.rhea-db.org/rhea/46680", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T7Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Y9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7Y9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Y9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHW9", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHW9-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLQPSPVLLASLGVGLLTLLGVALGAYLVRRSRRPPVTLLDPNEKYQLRLLDKTTVNHNTKRFRFALPTAHHVLGLPVGKHVYLSARIDGSLVIRPYTPVTSDEDQGYVDLVIKVYLKGVHPKFPEGGKMSQYLDSLKIGDVVEFRGPSGLLTYAGKGKFNIQPNKKAPPEARVARNLGMIAGGTGITPMLQLIRAILKDPEDPTQCFLLFANQTEKDIILREDLEELQARHPGRFKLWFTLDHPPEGWAYSKGFVSVDMIREHLPAPGEDVLLLLCGPPPMVQLACHPSLDKLGYSPKMRFTY", "length": 305, "header": "sp|Q3MHW9-1|NB5R1_BOVIN Isoform 1 of NADH-cytochrome b5 reductase 1 OS=Bos taurus OX=9913 GN=CYB5R1 PE=2 SV=1 CANONICAL=Q3MHW9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T7Y9-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9/entry#A0AAA9T7Y9-1", "sequence": { "sequence": "MGLQPSPVLLASLGVGLLTLLGVALGAYLVRRSRRPPVTLLDPNEKYQLRLLDKTTVNHNTKRFRFALPTAHHVLGLPVGKHVYLSARIDGSLVIRPYTPVTSDEDQGYVDLVIKVYLKGVHPKFPEGGKMSQYLDSLKIGDVVEFRGPSGLLTYAGKGKFNIQPNKKAPPEARVARNLGMIAGGTGITPMLQLIRAILKDPEDPTQCFLLFANQTEKDIILREDLEELQARHPGRFKLWFTLDHPPEDEVLIMEGSKMCSRSKASDGSLGLCDSRAYSFNQHLENYSHCPEASVQFSHSVVSNSLLSHGLKHARLPCPSPTPTACSNSRPWSRLFSLEKTLKDQDYNKPPCLCIFNRLITYQPCDK", "length": 367, "header": "tr|A0AAA9T7Y9-1|NB5R1_BOVIN Computationally mapped isoform of NADH-cytochrome b5 reductase 1 OS=Bos taurus OX=9913 GN=CYB5R1 PE=2 SV=1 CANONICAL=Q3MHW9-1" }, "locus": { "chromosome": "16", "start_pos": 79869664, "end_pos": 79860504, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136051.2", "url": "https://www.ensembl.org/id/ENSBTAT00000136051.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091966.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091966.1" } ] } }, { "isoform_ac": "Q3MHW9-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9/entry#Q3MHW9-1", "sequence": { "sequence": "MGLQPSPVLLASLGVGLLTLLGVALGAYLVRRSRRPPVTLLDPNEKYQLRLLDKTTVNHNTKRFRFALPTAHHVLGLPVGKHVYLSARIDGSLVIRPYTPVTSDEDQGYVDLVIKVYLKGVHPKFPEGGKMSQYLDSLKIGDVVEFRGPSGLLTYAGKGKFNIQPNKKAPPEARVARNLGMIAGGTGITPMLQLIRAILKDPEDPTQCFLLFANQTEKDIILREDLEELQARHPGRFKLWFTLDHPPEGWAYSKGFVSVDMIREHLPAPGEDVLLLLCGPPPMVQLACHPSLDKLGYSPKMRFTY", "length": 305, "header": "sp|Q3MHW9-1|NB5R1_BOVIN Isoform 1 of NADH-cytochrome b5 reductase 1 OS=Bos taurus OX=9913 GN=CYB5R1 PE=2 SV=1 CANONICAL=Q3MHW9-1" }, "locus": { "chromosome": "16", "start_pos": 79865001, "end_pos": 79860504, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026548.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026548.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026548.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026548.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:516287", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516287", "resource": "KEGG Pathway" }, { "id": "R-BTA-114608", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "resource": "Reactome", "description": "Platelet degranulation" }, { "id": "R-BTA-1237044", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1237044", "resource": "Reactome", "description": "Erythrocytes take up carbon dioxide and release oxygen" } ], "orthologs": [ { "uniprot_canonical_ac": "G3H3L4-1", "protein_name": "NADH-cytochrome b5 reductase", "gene_name": "LOC100752211", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGIQPSPVLLASLGVGLLTLLGLAVATYLVRRSRRSQVTLRDPDEKYLLRLLDKTTVSQNTKRFRFALPTANHILGLPVGKHVYLSARIDGNLVIRPYTPVTSDEDRGYVDLVIKVYLKGVHPKFPEGGKMSQYLDSLKIGDVVEFRGPSGLLNYAGKGNFYIQTNKNSPSELRVAKKLGMIAGGTGITPMLQLIRAILKVPEDPTQCFLLFANQTEKDIILREDLEELQAQYPNRFKLWFTLDHPPEGWTYSRGFVTADMIQQHLPPPADDVLVLLCGPPPMVQLACHPNLDKLCYSQKMRFTY", "length": 305 }, "evidence": [ { "id": "Q3MHW9", "url": "https://omabrowser.org/oma/group/Q3MHW9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q12746-1", "protein_name": "Plasma membrane-associated coenzyme Q6 reductase PGA3", "gene_name": "PGA3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSKEDIEGTNILDEPVHGIYIPAALFVVGVAITTYMSGELKILWSLPILFMIIFVRAYSAYKRRRSLYPDRWTSLELEDQTIISKNTALYRFKLKTRLESLDIPAGHHVAVRVPIDGKQEVRYYNPISSKLESGYLDLVVKAYVDGKVSKYFAGLNSGDTVDFKGPIGTLNYEPNSSKHLGIVAGGSGITPVLQILNEIITVPEDLTKVSLLYANETENDILLKDELDEMAEKYPHFQVHYVVHYPSDRWTGDVGYITKDQMNRYLPEYSEDNRLLICGPDGMNNLALQYAKELGWKVNSTRSSGDDQVFVF", "length": 312 }, "evidence": [ { "id": "Q3MHW9", "url": "https://omabrowser.org/oma/group/Q3MHW9/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q5EB81-1", "protein_name": "NADH-cytochrome b5 reductase 1", "gene_name": "Cyb5r1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGIQPSPVLLASLGVGLFTLFGLALGTYLVRRSRRPQVTLQDPDEKYLLRLLDKTTVSHNTRRFRFALPTAHHILGLPVGKHVYLSARIDGSQVIRPYTPVTSDEDQGYVDLVIKVYLKGVHPKFSEGGKMSQYLDSLKIGDVVEFRGPSGLLSYAGKGNFNIQPNKKSPPELRVAKKLGMIAGGTGITPMLQLIRAILKVPEDPTQCFLLFANQTEKDIILREDLEELQAQYPIRFKLWFTLDYPPEDWTYSKGFVTADMIQEHLPAPAEDVLLLLCGPPPMVQLACHPNLDKLGYSQKMRFTY", "length": 305 }, "evidence": [ { "id": "Q3MHW9", "url": "https://omabrowser.org/oma/group/Q3MHW9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9DB73-1", "protein_name": "NADH-cytochrome b5 reductase 1", "gene_name": "Cyb5r1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGIQPSPVLLASLGVGLLTLLGLALGTYLVRRSRRPQVTLQDPDEKYLLRLLDKTTVSHNTRRFRFALPTAHHILGLPVGKHVYLSARIDGSLVIRPYTPVTSDEDQGYVDLVIKVYLKGVHPKFPEGGKMSQYLDSLKIGDMVEFRGPSGLLSYAGKGNFNIQPNKKSPPELRVAKKLGMIAGGTGITPMLQLIRAILKVPEDPTQCFLLFANQTERDIILREDLEELQAQYPNRFKLWFTLDSPPEDWTYSKGFVTADMIQEHLPAPAEDVLLLLCGPPPMVQLACHPNLDKLGYSQKMRFTY", "length": 305 }, "evidence": [ { "id": "Q3MHW9", "url": "https://omabrowser.org/oma/group/Q3MHW9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UHQ9-1", "protein_name": "NADH-cytochrome b5 reductase 1", "gene_name": "CYB5R1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGIQTSPVLLASLGVGLVTLLGLAVGSYLVRRSRRPQVTLLDPNEKYLLRLLDKTTVSHNTKRFRFALPTAHHTLGLPVGKHIYLSTRIDGSLVIRPYTPVTSDEDQGYVDLVIKVYLKGVHPKFPEGGKMSQYLDSLKVGDVVEFRGPSGLLTYTGKGHFNIQPNKKSPPEPRVAKKLGMIAGGTGITPMLQLIRAILKVPEDPTQCFLLFANQTEKDIILREDLEELQARYPNRFKLWFTLDHPPKDWAYSKGFVTADMIREHLPAPGDDVLVLLCGPPPMVQLACHPNLDKLGYSQKMRFTY", "length": 305 }, "evidence": [ { "id": "Q3MHW9", "url": "https://omabrowser.org/oma/group/Q3MHW9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3MHW9", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3MHW9", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "FAD binding", "id": "GO:0071949", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071949", "evidence": [ { "database": "UniProtKB", "id": "Q3MHW9", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9" } ], "pmid": "" }, { "name": "cytochrome-b5 reductase activity, acting on NAD(P)H", "id": "GO:0004128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004128", "evidence": [ { "database": "UniProtKB", "id": "Q3MHW9", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9" } ], "pmid": "" }, { "name": "cytochrome-b5 reductase activity, acting on NADH", "id": "GO:0090524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090524", "evidence": [ { "database": "UniProtKB", "id": "Q3MHW9", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "sterol biosynthetic process", "id": "GO:0016126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016126", "evidence": [ { "database": "UniProtKB", "id": "Q3MHW9", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "46680", "name": "", "equation": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q32LH7-1", "Q3MHW9-1", "A0AAA9SH94-1", "P07514-1", "A0A3Q1MXD6-1" ], "evidence": [ { "id": "46680", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46680" } ] }, { "id": "R-BTA-481044", "name": "Surface deployment of platelet alpha granule membrane components", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHW9-1" ], "evidence": [ { "id": "R-BTA-481044", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-481044" } ] }, { "id": "R-BTA-6806831", "name": "CYB5Rs reduce MetHb to HbA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SH94-1", "Q32LH7-1", "Q3MHW9-1" ], "evidence": [ { "id": "R-BTA-6806831", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6806831" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MXD6", "gene_name": "CYB5R2", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+).", "evidence": [ { "id": "A0A3Q1MXD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXD6" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1MXD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXD6" } ] } ] }, { "uniprot_ac": "A0AAA9SH94", "gene_name": "CYB5RL", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+).", "evidence": [ { "id": "A0AAA9SH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH94" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9SH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH94" } ] } ] }, { "uniprot_ac": "P07514", "gene_name": "CYB5R3", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+).", "evidence": [ { "id": "P07514", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07514" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "P07514", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07514" } ] } ] }, { "uniprot_ac": "Q32LH7", "gene_name": "CYB5R4", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+).", "evidence": [ { "id": "Q32LH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LH7" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "Q32LH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LH7" } ] } ] }, { "uniprot_ac": "Q3MHW9", "gene_name": "CYB5R1", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+).", "evidence": [ { "id": "Q3MHW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "Q3MHW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHW9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 305, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHW9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHW9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3MHW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHW9" }, { "id": "PRU00716", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00716" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAD-binding FR-type", "eco_id": "ECO_0000255", "start_pos": 44, "end_pos": 156, "start_aa": "Asn", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.6.2.2", "ec_name": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+).", "evidence": [ { "id": "1.6.2.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2" }, { "id": "1.6.2.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.6.2.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 214, "end_pos": 216 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LB3-1", "uniprot_ac": "Q32LB3", "uniprot_id": "CXXC5_BOVIN", "mass": { "chemical_mass": 32650.0, "monoisotopic_mass": 32650.0 }, "refseq": { "ac": "NP_001033265", "name": "CXXC-type zinc finger protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033265" }, "gene_names": [ { "name": "CXXC5", "type": "recommended", "evidence": [ { "id": "Q32LB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB3" } ] }, { "name": "CXXC5", "type": "synonym", "evidence": [ { "id": "NP_001033265", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033265" } ] } ], "protein_names": [ { "name": "CXXC-type zinc finger protein 5", "type": "recommended", "evidence": [ { "id": "Q32LB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB3/entry#names_and_taxonomy" } ] }, { "name": "CXXC finger 5", "type": "synonym", "evidence": [ { "id": "NP_001033265", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033265" } ] }, { "name": "CXXC-type zinc finger protein 5", "type": "synonym", "evidence": [ { "id": "NP_001033265", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033265" } ] } ], "function": [ { "annotation": "May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32LB3", "url": "https://www.uniprot.org/uniprotkb/Q32LB3#function" }, { "database": "UniProtKB", "id": "Q7LFL8", "url": "https://www.uniprot.org/uniprotkb/Q7LFL8#function" }, { "database": "UniProtKB", "id": "Q5XIQ3", "url": "https://www.uniprot.org/uniprotkb/Q5XIQ3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LB3", "url": "https://www.uniprot.org/uniprotkb/Q32LB3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CXXC5", "url": "https://www.uniprot.org/uniprotkb/Q32LB3", "locus": { "chromosome": "7", "start_pos": 50886369, "end_pos": 50851737, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003986", "url": "https://www.ensembl.org/id/ENSBTAG00000003986" } ] } } ], "crossref": [ { "id": "Q32LB3", "url": "https://alphafold.ebi.ac.uk/entry/Q32LB3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003986", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003986", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538485", "url": "https://www.ncbi.nlm.nih.gov/gene/538485", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538485", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538485", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ANGHDPP", "url": "https://omabrowser.org/oma/group/ANGHDPP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32LB3", "url": "https://www.orthodb.org/?gene=Q32LB3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13419", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13419", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13419:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13419:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02008", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02008", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033265", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033265", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T8H7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8H7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8H7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8H7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LB3", "url": "https://www.uniprot.org/uniprotkb/Q32LB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LB3-1", "url": "https://www.uniprot.org/uniprotkb/Q32LB3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSLSSGPQDTGGSSSSSSNGSSGSGPKAGVADKSAAVAAAAPASVADDAPPPERRNKSGIISEPLNKSLRRSRPLSHYSSFGGSGGSGGGSMMGGESAEKAAAAAASLLANGHDLAAAMAVDKSNSTSKHKSSAVASLLSKAERATELGAEGQLTLQQFAQSTEMLKRVVQEHLPLMSEAGAGLPDMEAVAGAEALNGQSDFPYLGAFPINPGLFIMTPAGVFLAESALHMAGLAEYPMQGELASAISSGKKKRKRCGMCAPCRRRINCEQCSSCRNRKTGHQICKFRKCEELKKKPSAALEKVMLPTGAAFRWFQ", "length": 317, "header": "sp|Q32LB3-1|CXXC5_BOVIN Isoform 1 of CXXC-type zinc finger protein 5 OS=Bos taurus OX=9913 GN=CXXC5 PE=2 SV=2 CANONICAL=Q32LB3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T8H7-1", "url": "https://www.uniprot.org/uniprotkb/Q32LB3/entry#A0AAA9T8H7-1", "sequence": { "sequence": "MSSLSSGPQDTGGSSSSSSNGSSGSGPKAGVADKSAAVAAAAPASVADDAPPPERRNKSGIISEPLNKSLRRSRPLSHYSSFGGSGGSGGGSMMGGESAEKAAAAAASLLANGHDLAAAMAVDKSNSTSKHKSSAVASLLSKAERATELGAEGQLTLQQFAQSTEMLKRVVQEHLPLMSEAGAGLPDMEAVAGAEALNGQSDFPYLGAFPINPGLFIMTPAGVFLAESALHMAGLAEYPMQGELASAISSGKKKRKRCGMCAPCRRRINCEQCSSCRNRKTGHQICKFRKCEELKKKPSAALEVTAP", "length": 307, "header": "tr|A0AAA9T8H7-1|CXXC5_BOVIN Computationally mapped isoform of CXXC-type zinc finger protein 5 OS=Bos taurus OX=9913 GN=CXXC5 PE=2 SV=1 CANONICAL=Q32LB3-1" }, "locus": { "chromosome": "7", "start_pos": 50883822, "end_pos": 50882902, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127085.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127085.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075974.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075974.1" } ] } }, { "isoform_ac": "Q32LB3-1", "url": "https://www.uniprot.org/uniprotkb/Q32LB3/entry#Q32LB3-1", "sequence": { "sequence": "MSSLSSGPQDTGGSSSSSSNGSSGSGPKAGVADKSAAVAAAAPASVADDAPPPERRNKSGIISEPLNKSLRRSRPLSHYSSFGGSGGSGGGSMMGGESAEKAAAAAASLLANGHDLAAAMAVDKSNSTSKHKSSAVASLLSKAERATELGAEGQLTLQQFAQSTEMLKRVVQEHLPLMSEAGAGLPDMEAVAGAEALNGQSDFPYLGAFPINPGLFIMTPAGVFLAESALHMAGLAEYPMQGELASAISSGKKKRKRCGMCAPCRRRINCEQCSSCRNRKTGHQICKFRKCEELKKKPSAALEKVMLPTGAAFRWFQ", "length": 317, "header": "sp|Q32LB3-1|CXXC5_BOVIN Isoform 1 of CXXC-type zinc finger protein 5 OS=Bos taurus OX=9913 GN=CXXC5 PE=2 SV=2 CANONICAL=Q32LB3-1" }, "locus": { "chromosome": "7", "start_pos": 50885378, "end_pos": 50882902, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005204.5", "url": "https://www.ensembl.org/id/ENSBTAT00000005204.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005204.3", "url": "https://www.ensembl.org/id/ENSBTAP00000005204.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538485", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538485", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M3AX14-1", "protein_name": "CXXC-type zinc finger protein 5", "gene_name": "cxxc5a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSGGQPEGSRTPKAQDQDTDQDCGEDSPVIERRNRSGIISEPLSKSLKRSRTLSQYTAACPQTANGLKHNGQAKSHTAKPAQPAQQQPQQPSASALVPSKLDRTLEQVLEGQNGLLHFAQAAALLKRAGMEHMLLPGGMGVGVGGGEVGSVDLEGATVADTVGGHTDFPYGVGGGFPFNPGLFIMTPAGVFLADSALHMAGLTEYPVQSELASAISSGKKKRKRCGMCPPCRRRINCEQCSSCRNRKTGHQICKFRKCEELKKKPSAALEKVMLPTGAAFRWFQ", "length": 284 }, "evidence": [ { "id": "Q32LB3", "url": "https://omabrowser.org/oma/group/Q32LB3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1NCW6-1", "protein_name": "CXXC-type zinc finger protein 5", "gene_name": "CXXC5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSNSGSHQDTGNKPETEKNNQDDSHPPVSSERRNKSGIISEPLNKSLKKSRPLSHYSTFGSSSSVSEHSEKGNPLTNGNEATVDKSNSTSKHKNISSMLSKLDRVAEISSEGQNALQQFAQSTEMLKRVVQEHIPLASDHGTGISDMEAVSAAETMNSPSDFPYLGAFPINPGLFIMTPAGVFLAESALHMAGLAEYPMQNELASAINSGKKKRKRCGMCPPCRRRINCEQCSSCRNRKTGHQICKFRKCEELKKKPSAALEKVMLPTGAAFRWFQ", "length": 276 }, "evidence": [ { "id": "Q32LB3", "url": "https://omabrowser.org/oma/group/Q32LB3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q5XIQ3-1", "protein_name": "CXXC-type zinc finger protein 5", "gene_name": "Cxxc5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSLGGGSQDAGGSSSSSNTSSSSGSGQKAGGTDKSATVAATAPASVADDAPPPERRNKSGIISEPLNKSLRRSRPLSHYSSFGSSGGAGSMMGGESADKAAAAAASLLANGHDLAAAMAVDKSNPTSKHKSGAVASLLSKAERATELAAEGQLTLQQFAQSTEMLKRVVQEHLPLMSEAGAGLPDMEAVAGAEALNGQSDFPYLGAFPINPGLFIMTPAGVFLAESALHMAGLAEYPMQGELASAISSGKKKRKRCGMCAPCRRRINCEQCSSCRNRKTGHQICKFRKCEELKKKPSAALEKVMLPSGAAFRWFQ", "length": 316 }, "evidence": [ { "id": "Q32LB3", "url": "https://omabrowser.org/oma/group/Q32LB3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7LFL8-1", "protein_name": "CXXC-type zinc finger protein 5", "gene_name": "CXXC5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSLGGGSQDAGGSSSSSTNGSGGSGSSGPKAGAADKSAVVAAAAPASVADDTPPPERRNKSGIISEPLNKSLRRSRPLSHYSSFGSSGGSGGGSMMGGESADKATAAAAAASLLANGHDLAAAMAVDKSNPTSKHKSGAVASLLSKAERATELAAEGQLTLQQFAQSTEMLKRVVQEHLPLMSEAGAGLPDMEAVAGAEALNGQSDFPYLGAFPINPGLFIMTPAGVFLAESALHMAGLAEYPMQGELASAISSGKKKRKRCGMCAPCRRRINCEQCSSCRNRKTGHQICKFRKCEELKKKPSAALEKVMLPTGAAFRWFQ", "length": 322 }, "evidence": [ { "id": "Q32LB3", "url": "https://omabrowser.org/oma/group/Q32LB3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91WA4-1", "protein_name": "CXXC-type zinc finger protein 5", "gene_name": "Cxxc5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSLGGGSQDAGGSSSSSNTNSSSGSGQKAGGTDKSTAVAATTAPTSVADDAPPPERRNKSGIISEPLNKSLRRSRPLSHYSSFGSSGGGGSMMGVESADKAAAAAASLLANGHDLAAAMAVDKSNPTSKHKSGAVASLLSKAERATELAAEGQLTLQQFAQSTEMLKRVVQEHLPLMSEAGAGLPDMEAVAGAEALNGQSDFPYLGAFPINPGLFIMTPAGVFLAESALHMAGLAEYPMQGELASAISSGKKKRKRCGMCAPCRRRINCEQCSSCRNRKTGHQICKFRKCEELKKKPSAALEKVMLPSGAAFRWFQ", "length": 317 }, "evidence": [ { "id": "Q32LB3", "url": "https://omabrowser.org/oma/group/Q32LB3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q32LB3", "url": "https://www.uniprot.org/uniprotkb/Q32LB3" } ], "pmid": "" }, { "name": "regulation of generation of precursor metabolites and energy", "id": "GO:0043467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043467", "evidence": [ { "database": "UniProtKB", "id": "Q32LB3", "url": "https://www.uniprot.org/uniprotkb/Q32LB3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32LB3", "url": "https://www.uniprot.org/uniprotkb/Q32LB3" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q32LB3", "url": "https://www.uniprot.org/uniprotkb/Q32LB3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32LB3", "url": "https://www.uniprot.org/uniprotkb/Q32LB3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q32LB3", "url": "https://www.uniprot.org/uniprotkb/Q32LB3" } ], "pmid": "" }, { "name": "methyl-CpG binding", "id": "GO:0008327", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008327", "evidence": [ { "database": "UniProtKB", "id": "Q32LB3", "url": "https://www.uniprot.org/uniprotkb/Q32LB3" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "Q32LB3", "url": "https://www.uniprot.org/uniprotkb/Q32LB3" } ], "pmid": "" }, { "name": "DNA-binding transcription factor binding", "id": "GO:0140297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140297", "evidence": [ { "database": "UniProtKB", "id": "Q32LB3", "url": "https://www.uniprot.org/uniprotkb/Q32LB3" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q32LB3", "url": "https://www.uniprot.org/uniprotkb/Q32LB3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 20, "end_pos": 22, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" }, { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LB3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 317, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LB3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LB3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32LB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB3" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Nuclear localization signal", "eco_id": "ECO_0000255", "start_pos": 252, "end_pos": 257, "start_aa": "Lys", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "Q32LB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB3#function" }, { "id": "Q32LB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB3" }, { "id": "PRU00509", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00509" } ], "binding_site_uniprot": 258, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 258, "end_pos": 258, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32LB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB3#function" }, { "id": "Q32LB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB3" }, { "id": "PRU00509", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00509" } ], "binding_site_uniprot": 261, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 261, "end_pos": 261, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32LB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB3#function" }, { "id": "Q32LB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB3" }, { "id": "PRU00509", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00509" } ], "binding_site_uniprot": 264, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 264, "end_pos": 264, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32LB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB3#function" }, { "id": "Q32LB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB3" }, { "id": "PRU00509", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00509" } ], "binding_site_uniprot": 270, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 270, "end_pos": 270, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32LB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB3#function" }, { "id": "Q32LB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB3" }, { "id": "PRU00509", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00509" } ], "binding_site_uniprot": 273, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 273, "end_pos": 273, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32LB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB3#function" }, { "id": "Q32LB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB3" }, { "id": "PRU00509", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00509" } ], "binding_site_uniprot": 276, "amino_acid": "Cys", "chebi_lig_id": 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{ "uniprot_canonical_ac": "Q3SZN5-1", "uniprot_ac": "Q3SZN5", "uniprot_id": "DPOE3_BOVIN", "mass": { "chemical_mass": 16860.0, "monoisotopic_mass": 16860.0 }, "refseq": { "ac": "NP_001029562", "name": "DNA polymerase epsilon subunit 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029562" }, "gene_names": [ { "name": "POLE3", "type": "recommended", "evidence": [ { "id": "Q3SZN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5" } ] }, { "name": "POLE3", "type": "synonym", "evidence": [ { "id": "NP_001029562", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029562" } ] } ], "protein_names": [ { "name": "DNA polymerase epsilon subunit 3", "type": "recommended", "evidence": [ { "id": "Q3SZN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5/entry#names_and_taxonomy" } ] }, { "name": "DNA polymerase II subunit 3", "type": "synonym", "evidence": [ { "id": "NP_001029562", "database": "RefSeq", 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Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (By similarity). Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZN5", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5#function" }, { "database": "UniProtKB", "id": "Q9NRF9", "url": "https://www.uniprot.org/uniprotkb/Q9NRF9#function" }, { "database": "UniProtKB", "id": "Q04603", "url": "https://www.uniprot.org/uniprotkb/Q04603#function" } ] }, { "annotation": "Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T987", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T987#function" }, { "database": "UniProtKB", "id": "ARBA00045219", "url": "https://www.uniprot.org/uniprotkb/ARBA00045219#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZN5", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "POLE3", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5", "locus": { "chromosome": "8", "start_pos": 102655928, "end_pos": 102659985, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000252", "url": "https://www.ensembl.org/id/ENSBTAG00000000252" } 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"header": "tr|A0AAA9T987-1|DPOE3_BOVIN Computationally mapped isoform of DNA polymerase epsilon subunit 3 OS=Bos taurus OX=9913 GN=POLE3 PE=2 SV=1 CANONICAL=Q3SZN5-1" }, "locus": { "chromosome": "8", "start_pos": 102659971, "end_pos": 102657331, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116995.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116995.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093420.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093420.1" } ] } }, { "isoform_ac": "Q3SZN5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5/entry#Q3SZN5-1", "sequence": { "sequence": "MAERPEDLNLPNAVITRIIKEALPDGVNISKEARSAISRAASVFVLYATSCANNFAMKGKRKTLNASDVLSAMEEMEFQRFVTPLKEALEAYRREQKGKKEASEQKKKDKDKKTDSEEQDKSRDEDNDEDEERLEEEEQNEEEEVDN", "length": 147, "header": "sp|Q3SZN5-1|DPOE3_BOVIN Isoform 1 of DNA polymerase epsilon subunit 3 OS=Bos taurus OX=9913 GN=POLE3 PE=2 SV=1 CANONICAL=Q3SZN5-1" }, "locus": { "chromosome": "8", "start_pos": 102658492, "end_pos": 102657331, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000316.5", "url": "https://www.ensembl.org/id/ENSBTAT00000000316.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000316.4", "url": "https://www.ensembl.org/id/ENSBTAP00000000316.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 122, "end_pos": 122, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZN5", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5" } ], "site_lbl": "Ser122" }, { "start_pos": 83, "end_pos": 83, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZN5", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5" } ], "site_lbl": "Thr83" } ], "glycation": [], "keywords": [], "publication": [ { "title": 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"MAERPEDLNLPNAVITRIIKEALPEGVNISKEARSAISRAASVFVLYATSCANNFAMKGKRKTLNASDVLSAMEEMEFQRFVTPLKEALEAYRREQKGKKEASEQKKKDKDKKTDSEEQDKSRDEDNDEDEERLEEEEQNEEEDVDN", "length": 147 }, "evidence": [ { "id": "Q3SZN5", "url": "https://omabrowser.org/oma/group/Q3SZN5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1P2L0-1", "protein_name": "DNA polymerase epsilon subunit 3", "gene_name": "POLE3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAERPEDLNLPNAVITRIIKEALPDGVNISKEARSAISRAASVFVLYATSCANNFAMKGKRKTLNAGDVLSAMEEMEFQRFIAPLKESLEVYRREQKGKKEARKDKDKKADSEEQDKSREDDNDDDDERMEEEEQNDEEEVDN", "length": 143 }, "evidence": [ { "id": "Q3SZN5", "url": "https://omabrowser.org/oma/group/Q3SZN5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q642A5-1", "protein_name": "DNA polymerase epsilon subunit 3", "gene_name": "Pole3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAERPEDLNLPNAVITRIIKEALPDGVNISKEARSAISRAASVFVLYATSCANNFAMKGKRKTLNASDVLSAMEEMEFQRFVTPLKEALEAYRREQKGKKEASEQKKKDKDKKDCEEQDKSREEEDEDEERLDEEEQNEEEEVDN", "length": 145 }, "evidence": [ { "id": "Q3SZN5", "url": "https://omabrowser.org/oma/group/Q3SZN5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q75JQ9-1", "protein_name": "DNA polymerase epsilon subunit 3", "gene_name": "pole3", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSESQDLPGAIVNRIIKASLPEGVLCAKESRLAIAKAAKVWIHYLTAASIDFSSHSGRSTISPKDVFQAIEEIDFENFKPQLEEYLAALKSEKEKEKEKEKEKEKEKEKEKDSNKDDTKSKDENKSSKKSSSSSKDEK", "length": 138 }, "evidence": [ { "id": "Q3SZN5", "url": "https://omabrowser.org/oma/group/Q3SZN5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9JKP7-1", "protein_name": "DNA polymerase epsilon subunit 3", "gene_name": "Pole3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAERPEDLNLPNAVITRIIKEALPDGVNISKEARSAISRAASVFVLYATSCANNFAMKGKRKTLNASDVLSAMEEMEFQRFITPLKEALEAYRRDEKGKKEASEQKKKDKDKKDSEEQDKSREVEEEDEERLDEDDQNEEEEIDN", "length": 145 }, "evidence": [ { "id": "Q3SZN5", "url": "https://omabrowser.org/oma/group/Q3SZN5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NRF9-1", "protein_name": "DNA polymerase epsilon subunit 3", "gene_name": "POLE3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAERPEDLNLPNAVITRIIKEALPDGVNISKEARSAISRAASVFVLYATSCANNFAMKGKRKTLNASDVLSAMEEMEFQRFVTPLKEALEAYRREQKGKKEASEQKKKDKDKKTDSEEQDKSRDEDNDEDEERLEEEEQNEEEEVDN", "length": 147 }, "evidence": [ { "id": "Q3SZN5", "url": "https://omabrowser.org/oma/group/Q3SZN5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9V444-1", "protein_name": "DNA polymerase epsilon subunit 3", "gene_name": "Chrac-14", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVERIEDLNLPNAVIGRLIKEALPESASVSKEARAAIARAASVFAIFVTSSSTALAHKQNHKTITAKDILQTLTELDFESFVPSLTQDLEVYRKVVKEKKESKASKKDSNTAENANASATATAEEAPE", "length": 128 }, "evidence": [ { "id": "Q3SZN5", "url": "https://omabrowser.org/oma/group/Q3SZN5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "epsilon DNA polymerase complex", "id": "GO:0008622", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008622", "evidence": [ { "database": "UniProtKB", "id": "Q3SZN5", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5" } ], "pmid": "" }, { "name": "CHRAC", "id": "GO:0008623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008623", "evidence": [ { "database": "UniProtKB", "id": "Q3SZN5", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5" } ], "pmid": "" }, { "name": "ATAC complex", "id": "GO:0140672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140672", "evidence": [ { "database": "UniProtKB", "id": "Q3SZN5", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3SZN5", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "Q3SZN5", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "leading strand elongation", "id": "GO:0006272", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006272", "evidence": [ { "database": "UniProtKB", "id": "Q3SZN5", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q3SZN5", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "Q3SZN5", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5" } ], "pmid": "" }, { "name": "regulation of DNA replication", "id": "GO:0006275", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006275", "evidence": [ { "database": "UniProtKB", "id": "Q3SZN5", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5" } ], "pmid": "" }, { "name": "nucleosome assembly", "id": "GO:0006334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006334", "evidence": [ { "database": "UniProtKB", "id": "Q3SZN5", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5" } ], "pmid": "" }, { "name": "heterochromatin formation", "id": "GO:0031507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031507", "evidence": [ { "database": "UniProtKB", "id": "Q3SZN5", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "Q3SZN5", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5" } ], "pmid": "" }, { "name": "chromatin DNA binding", "id": "GO:0031490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031490", "evidence": [ { "database": "UniProtKB", "id": "Q3SZN5", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q3SZN5", "url": "https://www.uniprot.org/uniprotkb/Q3SZN5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZN5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 147, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZN5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZN5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 83, 122 ], "sequon_annotation_sites": [ { "start_pos": 28, "end_pos": 30 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3SX30-1", "uniprot_ac": "Q3SX30", "uniprot_id": "PSMF1_BOVIN", "mass": { "chemical_mass": 29705.0, "monoisotopic_mass": 29705.0 }, "refseq": { "ac": "NP_001069946", "name": "proteasome inhibitor PI31 subunit", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069946" }, "gene_names": [ { "name": "PSMF1", "type": "recommended", "evidence": [ { "id": "Q3SX30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX30" } ] }, { "name": "PSMF1", "type": "synonym", "evidence": [ { "id": "NP_001069946", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069946" } ] } ], "protein_names": [ { "name": "Proteasome inhibitor PI31 subunit", "type": "recommended", "evidence": [ { "id": "Q3SX30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX30/entry#names_and_taxonomy" } ] }, { "name": "proteasome (prosome, macropain) inhibitor subunit 1 (PI31)", "type": "synonym", "evidence": [ { "id": "NP_001069946", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069946" } ] }, { "name": "proteasome inhibitor PI31 subunit", "type": "synonym", "evidence": [ { "id": "NP_001069946", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069946" } ] } ], "function": [ { "annotation": "Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBB0#function" }, { "database": "UniProtKB", "id": "ARBA00024805", "url": "https://www.uniprot.org/uniprotkb/ARBA00024805#function" }, { "database": "UniProtKB", "id": "Q3SX30", "url": "https://www.uniprot.org/uniprotkb/Q3SX30#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SX30", "url": "https://www.uniprot.org/uniprotkb/Q3SX30" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSMF1", "url": "https://www.uniprot.org/uniprotkb/Q3SX30", "locus": { "chromosome": "13", "start_pos": 59967133, "end_pos": 60007443, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018417", "url": "https://www.ensembl.org/id/ENSBTAG00000018417" } ] } } ], "crossref": [ { "id": "Q3SX30", "url": "https://alphafold.ebi.ac.uk/entry/Q3SX30", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018417", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018417", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617807", "url": "https://www.ncbi.nlm.nih.gov/gene/617807", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "8FZ6", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8FZ6&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR013886", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013886", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021625", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021625", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617807", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617807", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PFGFPDI", "url": "https://omabrowser.org/oma/group/PFGFPDI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SX30", "url": "https://www.orthodb.org/?gene=Q3SX30", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13266", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13266", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13266:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13266:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00008fz6", "url": "https://www.rcsb.org/structure/pdb_00008fz6", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8FZ6", "url": "https://www.rcsb.org/structure/8FZ6", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF08577", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08577", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11566", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11566", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069946", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TBB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBB0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SX30", "url": "https://www.uniprot.org/uniprotkb/Q3SX30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SX30-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX30-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGLEVLFASAAPAITCAQDALVCFLHWEVVTHGYYGLGAGDQPGPNDKKSELLPVEWNSNKDLYVLRYESKDGSRKLLVKAVTVENSMIINVLEHGSQQVSDLTLNLNDYIDSEHLVDFHRVYKNSEELRSRIVSGIITPIHEQWEKANLSPHREFPPATAREVDPLRIHPQHPHTSRQPTWCDPLGPFAVGGEDLDPFGCRRGGMIVDPLRSGFPRALIDPSSGLPNRLPPGAVPPGARFDPFGPIGTSPSGPNPDHLPPPGYDDMYL", "length": 270, "header": "sp|Q3SX30-1|PSMF1_BOVIN Isoform 1 of Proteasome inhibitor PI31 subunit OS=Bos taurus OX=9913 GN=PSMF1 PE=1 SV=2 CANONICAL=Q3SX30-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TBB0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX30/entry#A0AAA9TBB0-1", "sequence": { "sequence": "MAGLEVLFASAAPAITCAQDALVCFLHWEVVTHGYYGLGAGDQPGPNDKKSELLPVEWNSNKDLYVLRYESKDGSRKLLVKAVTVENSMIINVLEHGSQQVSDLTLNLNDYIDSEHLVDFHRVYKNSEELRSRIVSGIITPIHEQWEKANLSPHREFPPATAREVDPLRIHPQHPHTSRQPTWCDPLGPFAVGGEDLDPFGCRRGGMIVDPLRSGFPRALIDPSSGLPNRLPPGAVPPGARFDPFGPIGTSPSGPRPDRRVQ", "length": 262, "header": "tr|A0AAA9TBB0-1|PSMF1_BOVIN Computationally mapped isoform of Proteasome inhibitor PI31 subunit OS=Bos taurus OX=9913 GN=PSMF1 PE=1 SV=1 CANONICAL=Q3SX30-1" }, "locus": { "chromosome": "13", "start_pos": 60007321, "end_pos": 59967136, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095848.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095848.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094132.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094132.1" } ] } }, { "isoform_ac": "Q3SX30-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX30/entry#Q3SX30-1", "sequence": { "sequence": "MAGLEVLFASAAPAITCAQDALVCFLHWEVVTHGYYGLGAGDQPGPNDKKSELLPVEWNSNKDLYVLRYESKDGSRKLLVKAVTVENSMIINVLEHGSQQVSDLTLNLNDYIDSEHLVDFHRVYKNSEELRSRIVSGIITPIHEQWEKANLSPHREFPPATAREVDPLRIHPQHPHTSRQPTWCDPLGPFAVGGEDLDPFGCRRGGMIVDPLRSGFPRALIDPSSGLPNRLPPGAVPPGARFDPFGPIGTSPSGPNPDHLPPPGYDDMYL", "length": 270, "header": "sp|Q3SX30-1|PSMF1_BOVIN Isoform 1 of Proteasome inhibitor PI31 subunit OS=Bos taurus OX=9913 GN=PSMF1 PE=1 SV=2 CANONICAL=Q3SX30-1" }, "locus": { "chromosome": "13", "start_pos": 60007321, "end_pos": 59968334, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024505.5", "url": "https://www.ensembl.org/id/ENSBTAT00000024505.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024505.4", "url": "https://www.ensembl.org/id/ENSBTAP00000024505.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 152, "end_pos": 152, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SX30", "url": "https://www.uniprot.org/uniprotkb/Q3SX30" } ], "site_lbl": "Ser152" }, { "start_pos": 251, "end_pos": 251, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SX30", "url": "https://www.uniprot.org/uniprotkb/Q3SX30" } ], "site_lbl": "Ser251" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q3SX30", "url": "https://www.uniprot.org/uniprotkb/Q3SX30" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:617807", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617807", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4II16-1", "protein_name": "Proteasome inhibitor PI31 subunit", "gene_name": "psmf1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAGLELLFNCVSNSLTCSQDALICFVHWEIVKSGYKCMGIGDEPKDGEKKTELLPSGWNESKELYALRYRSNDDKSNLLLKAFTVDSSLIFNLMDSTTEKVTDLTVNLSEYVDEANLHTFESVFKNTDELTAKLKSSLLPSKKEERQGKTEKKTERERASNLRDPDSDPLLIPTRGPPARHPANWPDPMAPFAAGGADLDPFGGRAGGMIVDPLRAGFPRSGFDPSSGIPGVLPPGAVPPGARFDPFGPVGRHRPGPDPDHMPPPGYDDMFM", "length": 272 }, "evidence": [ { "id": "Q3SX30", "url": "https://omabrowser.org/oma/group/Q3SX30/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8W4FHK5-1", "protein_name": "Proteasome inhibitor PI31 subunit", "gene_name": "PSMF1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVSRELGISTLLSLGNPELGAAASCHVLSIILGPRLWHGLCAAQAAGAQPERHLPSALLLSHSQASQGQLRPLLMARPGARMAGLEVLFASAAPTITCAQDALVCFLHWEVVTHGYYGLGAGDQPGPSDKKSELLPAEWNSNKDLYVLRYESKDGSRKLLVKAVTVENSMIINVLECGSQQVSDLTLNLNDYIDSEHLVDFHRAYKNSEELRSRIVSGIITPIHEHWDKASVSPHREFPPATAREVDPLRIHPHHPHTTHASPAIPLLEPSRVGVAVVLVHLTTFTSSPTAACHTCLPIIPSCLRCRRGGMIVDPLRSGFPRALIDPSSGLPNRLPPGAVPPGARFDPFGPIGTSPSGPNPDHLPPPGYDDMYL", "length": 374 }, "evidence": [ { "id": "Q3SX30", "url": "https://omabrowser.org/oma/group/Q3SX30/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H6Y0-1", "protein_name": "Proteasome inhibitor PI31 subunit", "gene_name": "Psmf1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAGLEVLFASAAPAISCPQDALVCFLHWEVVTNGYYVLGTGDQPDSSDKKSELLPPKWSSNKELYVLRYESKDGTKKLLLKAVSVESAMIINVLEHGTQQVADLTLNLDDYIDAEDLSDFHRTYKNGEELRSRIRSGIITPIHEQWEKARVSSPHREFPPATAREVDPLRIPSHHPHPSRQPPWRDPLSPFAVGGEDLDPFGCQRGGMIVDPLRSGFPRALIDPSSGLPNRLPPGAVPPGARFDPFGPIGTSPSGPNPDHLPPPGYDDMYL", "length": 271 }, "evidence": [ { "id": "Q3SX30", "url": "https://omabrowser.org/oma/group/Q3SX30/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q54S82-1", "protein_name": "Proteasome inhibitor PI31 subunit", "gene_name": "psmF1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MENFIKERLKSLIGNDNSIGIRDKYDVAVLVIALILNKHEFKLEGGEETNDKVVPTNWNSNADSYTLDLINHLAPGKTFHFKCLRMGNLLLVNAMIKDKNDKIHTLDVDTDKLVKNTEYKDVENLLLNLKEFISIFEYSIINPLVPGLVRIPTNMQEQQPQQQQQQQQQQQQERRPPNNQRDFEDDDPLRVGDPQRGSNRYRGGFNGGGDQDPDLYPPGFPVFGHNPPFYPGQTRGPGVFPGQGGQVGRDHPGFGNIHNPYGGGNNPYGTGLPGYEQRLPRGAVPPGARFDPFGPPTGGIPPSGRGRGMPDRDDFTPPGFDNDHYM", "length": 326 }, "evidence": [ { "id": "Q3SX30", "url": "https://omabrowser.org/oma/group/Q3SX30/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5XIU5-1", "protein_name": "Proteasome inhibitor PI31 subunit", "gene_name": "Psmf1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGLEVLFASAAPAMTCPQDALVCFLHWEVVTNGYYGLGTGDQPDPNDKKSELLPAEWNSNKELYALRYESKDGARKLLLKAVSVENGMIINVLEHGTQQVADLTLNLDDYIDAEDLSDFHRTYKNSEELRSRIRSGIITPIHEQWEKVRLSSPPREFPPATAREVDPLRISSHHPHTSRQPTWRDPLSPFAVGGEDLDPFGCQRGGMIVDPLRSGFPRALIDPSSGLPNRLPPGAVPPGARFDPFGPIGTSPSGPNPDHLPPPGYDDMYL", "length": 271 }, "evidence": [ { "id": "Q3SX30", "url": "https://omabrowser.org/oma/group/Q3SX30/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BHL8-1", "protein_name": "Proteasome inhibitor PI31 subunit", "gene_name": "Psmf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGLEVLFASAAPSMSCPQDALVCFLHWEVVTNGYYALGTGDQPGPSDKKSELLPAKWNSNKELYALRYESKDGARKLLLKAVSVENGMIINVLELGTQQVADLTLNLDDYIDAEDLSDFHRTYKNSEELRSQIRSGIITPIHEQWEKARANSPPREFPPATAREVDPLQISSHRPHTSRQPAWRDPLSPFAVGGDDLDPFGCQRGGMIVDPLRSGFPRVLIDPSSGLPNRLPPGAVPPGARFDPFGPIGTSPSGPNPDHLPPPGYDDMYL", "length": 271 }, "evidence": [ { "id": "Q3SX30", "url": "https://omabrowser.org/oma/group/Q3SX30/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92530-1", "protein_name": "Proteasome inhibitor PI31 subunit", "gene_name": "PSMF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGLEVLFASAAPAITCRQDALVCFLHWEVVTHGYFGLGVGDQPGPNDKKSELLPAGWNNNKDLYVLRYEYKDGSRKLLVKAITVESSMILNVLEYGSQQVADLTLNLDDYIDAEHLGDFHRTYKNSEELRSRIVSGIITPIHEQWEKANVSSPHREFPPATAREVDPLRIPPHHPHTSRQPPWCDPLGPFVVGGEDLDPFGPRRGGMIVDPLRSGFPRALIDPSSGLPNRLPPGAVPPGARFDPFGPIGTSPPGPNPDHLPPPGYDDMYL", "length": 271 }, "evidence": [ { "id": "Q3SX30", "url": "https://omabrowser.org/oma/group/Q3SX30/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9M330-1", "protein_name": "Probable proteasome inhibitor", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MANSQTVMAMIRLARPPFRNNHDKVAFAIHSSFVASGYILTATGRPAFADEALSSSSQNDVGIEGWNEFEGEYAFVYANPKKGSKKILVKCLAMDDKLLVDAIADGGAEPAHLEIKVGDYAEESNEGDYSAQFKNLDKLVTDLQSEIIDKLDGKPKPVASRAQSSSETNEEPRYYDDTPNPLGPQIHPSGVVVPPIPGNGGYSDLFPGPGAGMYPGRGGFGDGSMLVGPTDPRFFPFGDGSDRPGFMGPPHPGMPPPGARFDPYGPPGVPGFEPGRFTRQPPRGPGGGHPDLEHFPGGSDFI", "length": 302 }, "evidence": [ { "id": "Q3SX30", "url": "https://omabrowser.org/oma/group/Q3SX30/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9V637-1", "protein_name": "Proteasome inhibitor PI31 subunit", "gene_name": "PI31", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MESGSTAKTGDFFYGWDLLYKTVKADVSKKSDLLIALVHFLLTKHYNFRCVGVGDDKTLPEEEGSELLPDSWNDDDTKYSLRYVHDKMLYLLLGHITEGSLLINLLDINTKKVSNICVEPETLVPEVKGGITTIMPSASEIVERYRRELLDPVFTGNSREVTTQTTNSPRPIGSDPDPLRIGEPRRGGSFIPSAFEPRPFGFPDVGRGDLDPLGRGGHGNLFSFPSRPNMGPGPVPRFDPFNPLNPNRPGQGGINPDHMRPPDWNPDYYM", "length": 270 }, "evidence": [ { "id": "Q3SX30", "url": "https://omabrowser.org/oma/group/Q3SX30/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q3SX30", "url": "https://www.uniprot.org/uniprotkb/Q3SX30" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3SX30", "url": "https://www.uniprot.org/uniprotkb/Q3SX30" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "Q3SX30", "url": "https://www.uniprot.org/uniprotkb/Q3SX30" } ], "pmid": "" }, { "name": "proteasome complex", "id": "GO:0000502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000502", "evidence": [ { "database": "UniProtKB", "id": "Q3SX30", "url": "https://www.uniprot.org/uniprotkb/Q3SX30" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q3SX30", "url": "https://www.uniprot.org/uniprotkb/Q3SX30" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "Q3SX30", "url": "https://www.uniprot.org/uniprotkb/Q3SX30" } ], "pmid": "" }, { "name": "endopeptidase inhibitor activity", "id": "GO:0004866", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004866", "evidence": [ { "database": "UniProtKB", "id": "Q3SX30", "url": "https://www.uniprot.org/uniprotkb/Q3SX30" } ], "pmid": "" }, { "name": "proteasome binding", "id": "GO:0070628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070628", "evidence": [ { "database": "UniProtKB", "id": "Q3SX30", "url": "https://www.uniprot.org/uniprotkb/Q3SX30" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q3SX30", "url": "https://www.uniprot.org/uniprotkb/Q3SX30" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "Q3SX30", "url": "https://www.uniprot.org/uniprotkb/Q3SX30" } ], "pmid": "" }, { "name": "negative regulation of proteasomal protein catabolic process", "id": "GO:1901799", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901799", "evidence": [ { "database": "UniProtKB", "id": "Q3SX30", "url": "https://www.uniprot.org/uniprotkb/Q3SX30" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 150, "end_pos": 152, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SX30-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 270, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SX30-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SX30" }, { "pdb_id": "8fz6", "pdb_chain": "c/d", "start_pos": 1, "end_pos": 150, "overlap": "1.0", "method": "Electron_Microscopy", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/8fz6.pdb", "url_external": "https://www.rcsb.org/structure/8fz6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 152, 251 ], "sequon_annotation_sites": [ { "start_pos": 150, "end_pos": 152 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3T0K8-1", "uniprot_ac": "Q3T0K8", "uniprot_id": "EMC4_BOVIN", "mass": { "chemical_mass": 20087.0, "monoisotopic_mass": 20087.0 }, "refseq": { "ac": "NP_001029719", "name": "ER membrane protein complex subunit 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029719" }, "gene_names": [ { "name": "EMC4", "type": "recommended", "evidence": [ { "id": "Q3T0K8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K8" } ] }, { "name": "EMC4", "type": "synonym", "evidence": [ { "id": "NP_001029719", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029719" } ] }, { "name": "TMEM85", "type": "synonym", "evidence": [ { "id": "NP_001029719", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029719" }, { "id": "Q3T0K8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K8" } ] } ], "protein_names": [ { "name": "ER membrane protein complex subunit 4", "type": "recommended", "evidence": [ { "id": "Q3T0K8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K8/entry#names_and_taxonomy" } ] }, { "name": "ER membrane protein complex subunit 4", "type": "synonym", "evidence": [ { "id": "NP_001029719", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029719" } ] }, { "name": "Transmembrane protein 85", "type": "synonym", "evidence": [ { "id": "Q3T0K8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K8/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 85", "type": "synonym", "evidence": [ { "id": "NP_001029719", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029719" } ] } ], "function": [ { "annotation": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K8", "url": "https://www.uniprot.org/uniprotkb/Q3T0K8#function" }, { "database": "UniProtKB", "id": "Q5J8M3", "url": "https://www.uniprot.org/uniprotkb/Q5J8M3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0K8", "url": "https://www.uniprot.org/uniprotkb/Q3T0K8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EMC4", "url": "https://www.uniprot.org/uniprotkb/Q3T0K8", "locus": { "chromosome": "10", "start_pos": 28388336, "end_pos": 28391846, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006416", "url": "https://www.ensembl.org/id/ENSBTAG00000006416" } ] } } ], "crossref": [ { "id": "Q3T0K8", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0K8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006416", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006416", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "523162", "url": "https://www.ncbi.nlm.nih.gov/gene/523162", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523162", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523162", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FMMWMVG", "url": "https://omabrowser.org/oma/group/FMMWMVG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0K8", "url": "https://www.orthodb.org/?gene=Q3T0K8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19315", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19315", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06417", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06417", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029719", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TCZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDN9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0K8", "url": "https://www.uniprot.org/uniprotkb/Q3T0K8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0K8-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0K8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTAQGSLVANRGRRFKWAIELSGPGGGSRGRSDRGGGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISATFKMLESSSQKFLQGLVYLIGNLMGLALAVYKCQSMGLLPTHASDWLAFIEPPERMEFSGGGLLL", "length": 183, "header": "sp|Q3T0K8-1|EMC4_BOVIN Isoform 1 of ER membrane protein complex subunit 4 OS=Bos taurus OX=9913 GN=EMC4 PE=2 SV=1 CANONICAL=Q3T0K8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TCZ7-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0K8/entry#A0AAA9TCZ7-1", "sequence": { "sequence": "MTAQGSLVANRGRRFKWAIELSGPGGGSRGRSDRGGGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRMEFSGGGLLL", "length": 78, "header": "tr|A0AAA9TCZ7-1|EMC4_BOVIN Computationally mapped isoform of ER membrane protein complex subunit 4 OS=Bos taurus OX=9913 GN=EMC4 PE=2 SV=1 CANONICAL=Q3T0K8-1" }, "locus": { "chromosome": "10", "start_pos": 28391754, "end_pos": 28388671, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131656.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131656.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094619.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094619.1" } ] } }, { "isoform_ac": "A0AAA9TDN9-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0K8/entry#A0AAA9TDN9-1", "sequence": { "sequence": "MTAQGSLVANRGRRFKWAIELSGPGGGSRGRSDRGGGQGDSLYPVGYLDKQVPDTSVQETDRILVEKVQSL", "length": 71, "header": "tr|A0AAA9TDN9-1|EMC4_BOVIN Computationally mapped isoform of ER membrane protein complex subunit 4 OS=Bos taurus OX=9913 GN=EMC4 PE=2 SV=1 CANONICAL=Q3T0K8-1" }, "locus": { "chromosome": "10", "start_pos": 28391754, "end_pos": 28389313, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089002.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089002.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094887.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094887.1" } ] } }, { "isoform_ac": "Q3T0K8-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0K8/entry#Q3T0K8-1", "sequence": { "sequence": "MTAQGSLVANRGRRFKWAIELSGPGGGSRGRSDRGGGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISATFKMLESSSQKFLQGLVYLIGNLMGLALAVYKCQSMGLLPTHASDWLAFIEPPERMEFSGGGLLL", "length": 183, "header": "sp|Q3T0K8-1|EMC4_BOVIN Isoform 1 of ER membrane protein complex subunit 4 OS=Bos taurus OX=9913 GN=EMC4 PE=2 SV=1 CANONICAL=Q3T0K8-1" }, "locus": { "chromosome": "10", "start_pos": 28391754, "end_pos": 28388671, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008411.4", "url": "https://www.ensembl.org/id/ENSBTAT00000008411.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008411.3", "url": "https://www.ensembl.org/id/ENSBTAP00000008411.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:523162", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523162", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZIA2-1", "protein_name": "ER membrane protein complex subunit 4", "gene_name": "EMC4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTAQGSLVANRGRRFKWAIELSGPGGGSRGRSDRGGGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISATFKMLESSSQKFLQGLVYLIGNLMGLALAVYKCQSMGLLPTHASDWLAFIEPPERMEFSGGGLLL", "length": 183 }, "evidence": [ { "id": "Q3T0K8", "url": "https://omabrowser.org/oma/group/Q3T0K8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4A0W1-1", "protein_name": "ER membrane protein complex subunit 4", "gene_name": "Emc4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTTQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISATFKMLESSSQKFLQGLVYLIGNLMGLALAVYKCQSMGLLPTHASDWLAFIEPPERMEFSGGGLLL", "length": 183 }, "evidence": [ { "id": "Q3T0K8", "url": "https://omabrowser.org/oma/group/Q3T0K8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HIG8-1", "protein_name": "ER membrane protein complex subunit 4", "gene_name": "Emc4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTTQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISATFKMLESSSQKFLQGLVYLIGNLMGLALAVYKCQSMGLLPTHASDWLAFIEPPERMEFSGGGLLL", "length": 183 }, "evidence": [ { "id": "Q3T0K8", "url": "https://omabrowser.org/oma/group/Q3T0K8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5J8M3-1", "protein_name": "ER membrane protein complex subunit 4", "gene_name": "EMC4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTAQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISATFKMLESSSQKFLQGLVYLIGNLMGLALAVYKCQSMGLLPTHASDWLAFIEPPERMEFSGGGLLL", "length": 183 }, "evidence": [ { "id": "Q3T0K8", "url": "https://omabrowser.org/oma/group/Q3T0K8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CZX9-1", "protein_name": "ER membrane protein complex subunit 4", "gene_name": "Emc4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTTQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISATFKMLESSSQKFLQGLVYLIGNLMGLALAVYKCQSMGLLPTHASDWLAFIEPPERMEFSGGGLLL", "length": 183 }, "evidence": [ { "id": "Q3T0K8", "url": "https://omabrowser.org/oma/group/Q3T0K8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "EMC complex", "id": "GO:0072546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072546", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K8", "url": "https://www.uniprot.org/uniprotkb/Q3T0K8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K8", "url": "https://www.uniprot.org/uniprotkb/Q3T0K8" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K8", "url": "https://www.uniprot.org/uniprotkb/Q3T0K8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K8", "url": "https://www.uniprot.org/uniprotkb/Q3T0K8" } ], "pmid": "" }, { "name": "tail-anchored membrane protein insertion into ER membrane", "id": "GO:0071816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071816", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K8", "url": "https://www.uniprot.org/uniprotkb/Q3T0K8" } ], "pmid": "" }, { "name": "protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "id": "GO:0045050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045050", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K8", "url": "https://www.uniprot.org/uniprotkb/Q3T0K8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "membrane insertase activity", "id": "GO:0032977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032977", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K8", "url": "https://www.uniprot.org/uniprotkb/Q3T0K8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0K8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 183, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0K8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0K8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3Y598-1", "uniprot_ac": "Q3Y598", "uniprot_id": "FOXA3_BOVIN", "mass": { "chemical_mass": 37138.0, "monoisotopic_mass": 37138.0 }, "refseq": { "ac": "NP_001028291", "name": "hepatocyte nuclear factor 3-gamma", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028291" }, "gene_names": [ { "name": "FOXA3", "type": "recommended", "evidence": [ { "id": "Q3Y598", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3Y598" } ] }, { "name": "FOXA3", "type": "synonym", "evidence": [ { "id": "NP_001028291", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028291" } ] }, { "name": "HNF3-G", "type": "synonym", "evidence": [ { "id": "NP_001028291", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028291" } ] }, { "name": "HNF3G", "type": "synonym", "evidence": [ { "id": "Q3Y598", "database": 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"https://www.uniprot.org/uniprotkb/Q3Y598/entry#names_and_taxonomy" } ] }, { "name": "forkhead box protein A3", "type": "synonym", "evidence": [ { "id": "NP_001028291", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028291" } ] }, { "name": "foxhead box A3", "type": "synonym", "evidence": [ { "id": "NP_001028291", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028291" } ] }, { "name": "hepatocyte nuclear factor 3-gamma", "type": "synonym", "evidence": [ { "id": "NP_001028291", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028291" } ] } ], "function": [ { "annotation": "Transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3Y598", "url": "https://www.uniprot.org/uniprotkb/Q3Y598#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3Y598", "url": "https://www.uniprot.org/uniprotkb/Q3Y598" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FOXA3", "url": "https://www.uniprot.org/uniprotkb/Q3Y598", "locus": { "chromosome": "18", "start_pos": 53391815, "end_pos": 53384926, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012104", "url": "https://www.ensembl.org/id/ENSBTAG00000012104" } ] } } ], "crossref": [ { "id": "Q3Y598", "url": "https://alphafold.ebi.ac.uk/entry/Q3Y598", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012104", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012104", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20040", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20040", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "503622", "url": "https://www.ncbi.nlm.nih.gov/gene/503622", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030456", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030456", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047366", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047366", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050211", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050211", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:503622", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:503622", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SHDISEW", "url": "https://omabrowser.org/oma/group/SHDISEW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3Y598", "url": "https://www.orthodb.org/?gene=Q3Y598", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11829", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11829", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11829:SF201", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11829:SF201", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00250", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00250", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08430", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08430", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001028291", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028291", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TD46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD46-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YWX6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YWX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YWX6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3Y598", "url": "https://www.uniprot.org/uniprotkb/Q3Y598", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3Y598-1", "url": "https://www.uniprot.org/uniprotkb/Q3Y598-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGSVKMEAHDLAEWSYYPEAGEVYSPVTPVPTMAPLNSYMTLNPLSSPYPPGGLPASPLPTGPLAPPAPTAPLGPTFPGLGASTGGGSSSGYGGPGPGLVHGKEMPKGYRRPLAHAKPPYSYISLITMAIQQAPGKMLTLSEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPSSGNMFENGCYLRRQKRFKLEEKVKKGGGGSSASRNSAGSASTATAPAATVASTPQPQPPPPEPEAQGGDEVGALDCGSPAAPSTPYFTGLELPGELKLDAPYNFNHPFSINNLMSEQSPAPPKLDVGFGGYGAEGGEPGVYYQGLYSRSLLNAS", "length": 351, "header": "sp|Q3Y598-1|FOXA3_BOVIN Isoform 1 of Hepatocyte nuclear factor 3-gamma OS=Bos taurus OX=9913 GN=FOXA3 PE=2 SV=1 CANONICAL=Q3Y598-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TD46-1", "url": "https://www.uniprot.org/uniprotkb/Q3Y598/entry#A0AAA9TD46-1", "sequence": { "sequence": "MAPLNSYMTLNPLSSPYPPGGLPASPLPTGPLAPPAPTAPLGPTFPGLGASTGGGSSSGYGGPGPGLVHGKEMPKGYRRPLAHAKPPYSYISLITMAIQQAPGKMLTLSEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPSSGNMFENGCYLRRQKRFKLEEKVKKGGGGSSASRNSAGSASTATAPAATVASTPQPQPPPPEPEAQGGDEVGALDCGSPAAPSTPYFTGLELPGELKLDAPYNFNHPFSINNLMSEQSPAPPKLDVGFGGYGAEGGEPGVYYQGLYSRSLLNAS", "length": 318, "header": "tr|A0AAA9TD46-1|FOXA3_BOVIN Computationally mapped isoform of Hepatocyte nuclear factor 3-gamma OS=Bos taurus OX=9913 GN=FOXA3 PE=2 SV=1 CANONICAL=Q3Y598-1" }, "locus": { "chromosome": "18", "start_pos": 53390811, "end_pos": 53389858, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095262.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095262.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096568.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096568.1" } ] } }, { "isoform_ac": "A0AAF6YWX6-1", "url": "https://www.uniprot.org/uniprotkb/Q3Y598/entry#A0AAF6YWX6-1", "sequence": { "sequence": "MSCGRWKTPLYARESNQVKKVYSPVTPVPTMAPLNSYMTLNPLSSPYPPGGLPASPLPTGPLAPPAPTAPLGPTFPGLGASTGGGSSSGYGGPGPGLVHGKEMPKGYRRPLAHAKPPYSYISLITMAIQQAPGKMLTLSEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPSSGNMFENGCYLRRQKRFKLEEKVKKGGGGSSASRNSAGSASTATAPAATVASTPQPQPPPPEPEAQGGDEVGALDCGSPAAPSTPYFTGLELPGELKLDAPYNFNHPFSINNLMSEQSPAPPKLDVGFGGYGAEGGEPGVYYQGLYSRSLLNAS", "length": 348, "header": "tr|A0AAF6YWX6-1|FOXA3_BOVIN Computationally mapped isoform of Hepatocyte nuclear factor 3-gamma OS=Bos taurus OX=9913 GN=FOXA3 PE=2 SV=1 CANONICAL=Q3Y598-1" }, "locus": { "chromosome": "18", "start_pos": 53390811, "end_pos": 53389441, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016056.5", "url": "https://www.ensembl.org/id/ENSBTAT00000016056.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016056.4", "url": "https://www.ensembl.org/id/ENSBTAP00000016056.4" } ] } }, { "isoform_ac": "Q3Y598-1", "url": "https://www.uniprot.org/uniprotkb/Q3Y598/entry#Q3Y598-1", "sequence": { "sequence": "MLGSVKMEAHDLAEWSYYPEAGEVYSPVTPVPTMAPLNSYMTLNPLSSPYPPGGLPASPLPTGPLAPPAPTAPLGPTFPGLGASTGGGSSSGYGGPGPGLVHGKEMPKGYRRPLAHAKPPYSYISLITMAIQQAPGKMLTLSEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPSSGNMFENGCYLRRQKRFKLEEKVKKGGGGSSASRNSAGSASTATAPAATVASTPQPQPPPPEPEAQGGDEVGALDCGSPAAPSTPYFTGLELPGELKLDAPYNFNHPFSINNLMSEQSPAPPKLDVGFGGYGAEGGEPGVYYQGLYSRSLLNAS", "length": 351, "header": "sp|Q3Y598-1|FOXA3_BOVIN Isoform 1 of Hepatocyte nuclear factor 3-gamma OS=Bos taurus OX=9913 GN=FOXA3 PE=2 SV=1 CANONICAL=Q3Y598-1" }, "locus": { "chromosome": "18", "start_pos": 53390811, "end_pos": 53384988, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131953.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131953.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103894.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103894.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 29, "start_aa": "Thr", "end_pos": 29, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr29", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 71, "start_aa": "Thr", "end_pos": 71, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr71", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:503622", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:503622", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RM41-1", "protein_name": "Forkhead box A3", "gene_name": "FOXA3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLGSVKMEAHDLAEWSYYPEAGEVYSPVTPVPTMAPLNSYMTLNPLSSPYPPGGLPASPLPTGPLAPPAPTAPLGPTFPGLGASSGGGSSSGYGGPGSGLVHGNEMPKGYRRPLAHAKPPYSYISLITMAIQQAPGKMLTLSEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPSSGNMFENGCYLRRQKRFKLEEKVKKGGGGTSASRNSAGSASSTSTPAAPVTSPPKPQPPPAEPEAQSAEDVGALDCGSPPSSTPYFSGLDLPGELKLDAPYNFNHPFSINNLMSEQTPAPPKLDVGFGGYGAEGGEPGVYYQGLYSRSLLNAS", "length": 350 }, "evidence": [ { "id": "Q3Y598", "url": "https://omabrowser.org/oma/group/Q3Y598/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P32183-1", "protein_name": "Hepatocyte nuclear factor 3-gamma", "gene_name": "Foxa3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLGSVKMEAHDLAEWSYYPEAGEVYSPVNPVPTMAPLNSYMSLNPLSSPYPPGGLQASPLPTGPLAPPAPTAPLGPTFPGLGAGSGTGGSASGYGAPGPGLVHGKEMAKGYRRPLTHAKPPYSYISLITMAIQQAPGKMLTLSEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPSSGNMFENGCYLRRQKRFKLEEKAKKGNSATSATRNGTVGSATSATTTAATAVTSPAQPQPTPPSEPEAQSGEDVGGLDCASPPSSAPYFTGLELPGELKLDAPYNFNHPFSINNLMSEQTSTPSKLDVGFGGYGAESGEPGVYYQSLYSRSLLNAS", "length": 354 }, "evidence": [ { "id": "Q3Y598", "url": "https://omabrowser.org/oma/group/Q3Y598/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P35584-1", "protein_name": "Hepatocyte nuclear factor 3-gamma", "gene_name": "Foxa3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLGSVKMEAHDLAEWSYYPEAGEVYSPVNPVPTMAPLNSYMTLNPLSSPYPPGGLQASPLPTGPLAPPAPTAPLGPTFPSLGTGGSTGGSASGYVAPGPGLVHGKEMAKGYRRPLAHAKPPYSYISLITMAIQQAPGKMLTLSEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPSSGNMFENGCYLRRQKRFKLEEKAKKGNSATSASRNGTAGSATSATTTAATAVTSPAQPQPTPSEPEAQSGDDVGGLDCASPPSSTPYFSGLELPGELKLDAPYNFNHPFSINNLMSEQTSTPSKLDVGFGGYGAESGEPGVYYQSLYSRSLLNAS", "length": 353 }, "evidence": [ { "id": "Q3Y598", "url": "https://omabrowser.org/oma/group/Q3Y598/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P55318-1", "protein_name": "Hepatocyte nuclear factor 3-gamma", "gene_name": "FOXA3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLGSVKMEAHDLAEWSYYPEAGEVYSPVTPVPTMAPLNSYMTLNPLSSPYPPGGLPASPLPSGPLAPPAPAAPLGPTFPGLGVSGGSSSSGYGAPGPGLVHGKEMPKGYRRPLAHAKPPYSYISLITMAIQQAPGKMLTLSEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPSSGNMFENGCYLRRQKRFKLEEKVKKGGSGAATTTRNGTGSAASTTTPAATVTSPPQPPPPAPEPEAQGGEDVGALDCGSPASSTPYFTGLELPGELKLDAPYNFNHPFSINNLMSEQTPAPPKLDVGFGGYGAEGGEPGVYYQGLYSRSLLNAS", "length": 350 }, "evidence": [ { "id": "Q3Y598", "url": "https://omabrowser.org/oma/group/Q3Y598/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3Y598", "url": "https://www.uniprot.org/uniprotkb/Q3Y598" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3Y598", "url": "https://www.uniprot.org/uniprotkb/Q3Y598" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3Y598", "url": "https://www.uniprot.org/uniprotkb/Q3Y598" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q3Y598", "url": "https://www.uniprot.org/uniprotkb/Q3Y598" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q3Y598", "url": "https://www.uniprot.org/uniprotkb/Q3Y598" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q3Y598", "url": "https://www.uniprot.org/uniprotkb/Q3Y598" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "Q3Y598", "url": "https://www.uniprot.org/uniprotkb/Q3Y598" } ], "pmid": "" }, { "name": "anatomical structure morphogenesis", "id": "GO:0009653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009653", "evidence": [ { "database": "UniProtKB", "id": "Q3Y598", "url": "https://www.uniprot.org/uniprotkb/Q3Y598" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "Q3Y598", "url": "https://www.uniprot.org/uniprotkb/Q3Y598" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q3Y598", "url": "https://www.uniprot.org/uniprotkb/Q3Y598" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q3Y598", "url": "https://www.uniprot.org/uniprotkb/Q3Y598" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "Q3Y598", "url": "https://www.uniprot.org/uniprotkb/Q3Y598" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "Q3Y598", "url": "https://www.uniprot.org/uniprotkb/Q3Y598" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 349, "end_pos": 351, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3Y598-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 351, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3Y598-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3Y598" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3Y598", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3Y598" }, { "id": "PRU00089", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00089" } ], "ann_type": "Nucleotide_Binding_Annotation", "uniprotkb_annotation": "Fork-head", "eco_id": "ECO_0000255", "start_pos": 118, "end_pos": 212, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 29, 71 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 349, "end_pos": 351 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", 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[ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LJ6-1", "uniprot_ac": "Q32LJ6", "uniprot_id": "RABL3_BOVIN", "mass": { "chemical_mass": 26383.0, "monoisotopic_mass": 26383.0 }, "refseq": { "ac": "NP_001070274", "name": "rab-like protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070274" }, "gene_names": [ { "name": "RABL3", "type": "recommended", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ] }, { "name": "RABL3", "type": "synonym", "evidence": [ { "id": "NP_001070274", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070274" } ] } ], "protein_names": [ { "name": "Rab-like protein 3", "type": "recommended", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6/entry#names_and_taxonomy" } ] }, { "name": "3.6.5.2", "type": "synonym", "evidence": [ { "id": "Q32LJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6/entry#names_and_taxonomy" } ] }, { "name": "rab-like protein 3", "type": "synonym", "evidence": [ { "id": "NP_001070274", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070274" } ] } ], "function": [ { "annotation": "Small GTPase required for KRAS signaling regulation and modulation of cell proliferation. Regulator of KRAS prenylation, and probably prenylation of other small GTPases. Required for lymphocyte development and function. Not required for myeloid cell development. Interacts with Rab11 to promote ciliary vesicle formation at the mother centriole, thereby regulating early ciliogenesis. The GTP-binding capacity of RABL3 is essential for ciliogenesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH97#function" }, { "database": "UniProtKB", "id": "ARBA00094278", "url": "https://www.uniprot.org/uniprotkb/ARBA00094278#function" }, { "database": "UniProtKB", "id": "Q32LJ6", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6#function" }, { "database": "UniProtKB", "id": "Q9D4V7", "url": "https://www.uniprot.org/uniprotkb/Q9D4V7#function" }, { "database": "UniProtKB", "id": "Q5HYI8", "url": "https://www.uniprot.org/uniprotkb/Q5HYI8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LJ6", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RABL3", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6", "locus": { "chromosome": "1", "start_pos": 65387679, "end_pos": 65434455, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015898", "url": "https://www.ensembl.org/id/ENSBTAG00000015898" } ] } } ], "crossref": [ { "id": "Q32LJ6", "url": "https://alphafold.ebi.ac.uk/entry/Q32LJ6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015898", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015898", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04102", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04102", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505510", "url": "https://www.ncbi.nlm.nih.gov/gene/505510", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505510", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505510", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "THLICQQ", "url": "https://omabrowser.org/oma/group/THLICQQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32LJ6", "url": "https://www.orthodb.org/?gene=Q32LJ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24073", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24073", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08477", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08477", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070274", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TH97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH97-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH97-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LJ6", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LJ6-1", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LJ6-2", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASLDRVKVLVLGDSGVGKSSLVHLLCQNQVLGNPSWTVGCSVDVRVHDYKEGTPEEKTYYIELWDVGGSVGSASSVKSTRAVFYNSVNGIILVHDLTNKKSSQNLYRWSLEALNRDLVPTGVLVTNGDYDREQFADNQIPLLVIGTKLDQIHENKRHEVLTRTAFLAEDFNAEEINLDCTNPRYLAAGSSNAVKLSRFFDKVIEKRYFLRDGNQIPGFPDRKRFGGGTLKSLHYD", "length": 236, "header": "sp|Q32LJ6-1|RABL3_BOVIN Isoform 1 of Rab-like protein 3 OS=Bos taurus OX=9913 GN=RABL3 PE=2 SV=2 CANONICAL=Q32LJ6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TH97-1", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6/entry#A0AAA9TH97-1", "sequence": { "sequence": "MASLDRVKVLVLGDSGVGKSSLVHLLCQNQVLGNPSWTVGCSVDVRVHDYKEGTPEEKTYYIELWDVGGSVGSASSVKSTRAVFYNSVNGIILVHDLTNKKSSQNLYRWSLEALNRDLVPTGVLVTNGDYDREQFADNQIPLLVIGTKLDQIHENKRHEVLTRTAFLAEDFNAEEINLVIEKRYFLRDGNQIPGFPDRKRFGGGTLKSLHYD", "length": 212, "header": "tr|A0AAA9TH97-1|RABL3_BOVIN Computationally mapped isoform of Rab-like protein 3 OS=Bos taurus OX=9913 GN=RABL3 PE=2 SV=1 CANONICAL=Q32LJ6-1" }, "locus": { "chromosome": "1", "start_pos": 65433966, "end_pos": 65388908, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122097.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122097.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097616.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097616.1" } ] } }, { "isoform_ac": "Q32LJ6-1", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6/entry#Q32LJ6-1", "sequence": { "sequence": "MASLDRVKVLVLGDSGVGKSSLVHLLCQNQVLGNPSWTVGCSVDVRVHDYKEGTPEEKTYYIELWDVGGSVGSASSVKSTRAVFYNSVNGIILVHDLTNKKSSQNLYRWSLEALNRDLVPTGVLVTNGDYDREQFADNQIPLLVIGTKLDQIHENKRHEVLTRTAFLAEDFNAEEINLDCTNPRYLAAGSSNAVKLSRFFDKVIEKRYFLRDGNQIPGFPDRKRFGGGTLKSLHYD", "length": 236, "header": "sp|Q32LJ6-1|RABL3_BOVIN Isoform 1 of Rab-like protein 3 OS=Bos taurus OX=9913 GN=RABL3 PE=2 SV=2 CANONICAL=Q32LJ6-1" }, "locus": { "chromosome": "1", "start_pos": 65433966, "end_pos": 65388908, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021130.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021130.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021130.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021130.6" } ] } }, { "isoform_ac": "Q32LJ6-2", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6/entry#Q32LJ6-2", "sequence": { "sequence": "MASLDRVKVLVLGDSGVGKSSLVHLLCQNQVLGNPSWTVGCSVDVRVHDYKEGTPEEKTYYIELWDVGGSVGSASSVKSTRAVFYNSVNGIILVHDLTNKKSSQNLYRWSLEALNRDLVPTGVLVTNGD", "length": 129, "header": "sp|Q32LJ6-2|RABL3_BOVIN Isoform 2 of Rab-like protein 3 OS=Bos taurus OX=9913 GN=RABL3 PE=2 SV=2 CANONICAL=Q32LJ6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:505510", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505510", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061I233-1", "protein_name": "Rab-like protein 3", "gene_name": "Rabl3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASLDRVKVLVLGDSGVGKSSLVHLLCHNQVLGNPSWTVGCSVDIRVHDYKEGTPEEKTYYIELWDVGGSVGSASSVKSTRAVFYNSVNGIILVHDLTNKKSSQNLYRWSLEVLNRDLVPTGVLVTNGDYDREQFADNQIPLLVIGTKLDQIHETKRHEVSIRTAFLAEDFNAEEINLDCTNPRSSAAGSSNAVKLSRFFDKVIEKRYFCREGNQIPGFPDRKRFGGGTLKNFHYD", "length": 236 }, "evidence": [ { "id": "Q32LJ6", "url": "https://omabrowser.org/oma/group/Q32LJ6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A4X1T6W7-1", "protein_name": "Rab-like protein 3", "gene_name": "RABL3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASLDRVKVLVLGDSGVGKSSLVHLLCQNQVLGNPSWTVGCSVDVRVHDYKEGTPEEKTYYIELWDVGGSVGSASSVKSTRAVFYNSVNGIILVHDLTNKKSSQNLYRWSLEALNRDLVPTGVLVTNGDYDREQFADNQIPLLVIGTKLDQIHETKRHEVLTRTAFLAEDFNAEEINLDCTNPRYLAAGSSNAVKLSRFFDKVIEKRYFLRDGNQIPGFPDRKRFGGGTLKSLHYD", "length": 236 }, "evidence": [ { "id": "Q32LJ6", "url": "https://omabrowser.org/oma/group/Q32LJ6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6A072-1", "protein_name": "Rab-like protein 3", "gene_name": "Rabl3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "NPGQKLVSPNLKISIKGVGKSSLVHLLCHNQVLGNPSWTVGCSVDIRVHDYKEGTPEEKTYYIELWDVGGSVGSASSVKSTRAVFYNSVNGIILVHDLTNKKSSQNLYRWSLEVLNRDAVPTGVLVTNGDYDREQFADNQIPLLVIGTKLDQIHETKRHEVLIRTAFLAEDFNAEEINLDCTNPRSSAAGSSNAVKLSRFFDKVIEKRYLFREGNQIPGFSDRKRFGGGTLKNFHCD", "length": 237 }, "evidence": [ { "id": "Q32LJ6", "url": "https://omabrowser.org/oma/group/Q32LJ6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6TNS7-1", "protein_name": "Rab-like protein 3", "gene_name": "rabl3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MASLDRVKVLVLGDSGVGKSSLVHLLCQNQVLGNPSWTVGCSVDVRVHDYREGTPEEKAFYIELWDVGGSVGSASSVKSTRAVFYNSVNGIILVHDLTNKKSSQNLYRWSLEALSKDSSPTGIIVSNGDYDREQFAENAVPLLLIGTKFDQIPENKRNDVLTRTAFLSEDFNAEEINLDCTNPRYLAAGSSNAVKLSRFFDKVIEKRYFTRDPSQMQSFTDRRRFNFKSLHSD", "length": 233 }, "evidence": [ { "id": "Q32LJ6", "url": "https://omabrowser.org/oma/group/Q32LJ6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9D4V7-1", "protein_name": "Rab-like protein 3", "gene_name": "Rabl3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASLDRVKVLVLGDSGVGKSSLVHLLCHNQVLGNPSWTVGCSVDIRVHDYKEGTPEEKTYYIELWDVGGSVGSASSVKSTRAVFYNSVNGIILVHDLTNKKSSQNLYRWSLEVLNRDAVPTGVLVTNGDYDREQFADNQIPLLVIGTKLDQIHETKRHEVLIRTAFLAEDFNAEEINLDCTNPRSSAAGSSNAVKLSRFFDKVIEKRYFFREGNQIPGFSDRKRFGGGALKNFHCD", "length": 236 }, "evidence": [ { "id": "Q32LJ6", "url": "https://omabrowser.org/oma/group/Q32LJ6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "natural killer cell differentiation", "id": "GO:0001779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001779", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ6", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ], "pmid": "" }, { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ6", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ6", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ], "pmid": "" }, { "name": "B cell differentiation", "id": "GO:0030183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030183", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ6", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ], "pmid": "" }, { "name": "T cell differentiation in thymus", "id": "GO:0033077", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033077", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ6", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ], "pmid": "" }, { "name": "regulation of Ras protein signal transduction", "id": "GO:0046578", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046578", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ6", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ], "pmid": "" }, { "name": "positive regulation of cilium assembly", "id": "GO:0045724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045724", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ6", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ], "pmid": "" }, { "name": "regulation of protein lipidation", "id": "GO:1903059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903059", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ6", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ6", "url": "https://www.uniprot.org/uniprotkb/Q32LJ6" } ], "pmid": "" }, { "name": "GTP binding", "id": 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} ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2NKU3-1", "uniprot_ac": "Q2NKU3", "uniprot_id": "BUD31_BOVIN", "mass": { "chemical_mass": 17000.0, "monoisotopic_mass": 17000.0 }, "refseq": { "ac": "NP_001039829", "name": "protein BUD31 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039829" }, "gene_names": [ { "name": "BUD31", "type": "recommended", "evidence": [ { "id": "Q2NKU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKU3" } ] }, { "name": "BUD31", "type": "synonym", "evidence": [ { "id": "NP_001039829", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039829" } ] } ], "protein_names": [ { "name": "Protein BUD31 homolog", "type": "recommended", "evidence": [ { "id": "Q2NKU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKU3/entry#names_and_taxonomy" } ] }, { "name": "Protein G10 homolog", "type": "synonym", "evidence": [ { "id": "Q2NKU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKU3/entry#names_and_taxonomy" } ] }, { "name": "protein BUD31 homolog", "type": "synonym", "evidence": [ { "id": "NP_001039829", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039829" } ] }, { "name": "protein G10 homolog", "type": "synonym", "evidence": [ { "id": "NP_001039829", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039829" } ] } ], "function": [ { "annotation": "Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity.", "evidence": [ { "database": "UniProtKB", "id": "Q2NKU3", "url": "https://www.uniprot.org/uniprotkb/Q2NKU3#function" }, { "database": "UniProtKB", "id": "P41223", "url": "https://www.uniprot.org/uniprotkb/P41223#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NKU3", "url": "https://www.uniprot.org/uniprotkb/Q2NKU3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BUD31", "url": "https://www.uniprot.org/uniprotkb/Q2NKU3", "locus": { "chromosome": "25", "start_pos": 36983069, "end_pos": 36991608, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020439", "url": "https://www.ensembl.org/id/ENSBTAG00000020439" } ] } } ], "crossref": [ { "id": "Q2NKU3", "url": "https://alphafold.ebi.ac.uk/entry/Q2NKU3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020439", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020439", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533977", "url": "https://www.ncbi.nlm.nih.gov/gene/533977", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001748", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001748", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018230", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018230", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533977", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533977", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FGTSCIC", "url": "https://omabrowser.org/oma/group/FGTSCIC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NKU3", "url": "https://www.orthodb.org/?gene=Q2NKU3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19411", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19411", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19411:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19411:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01125", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01125", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039829", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TIV3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIV3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIV3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIV3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZD28", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZD28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZD28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZD28-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NKU3", "url": "https://www.uniprot.org/uniprotkb/Q2NKU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NKU3-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKU3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPKVKRSRKAPPDGWELIEPTLDELDQKMREAETEPHEGKRKVESLWPIFRIHHQKTRYIFDLFYKRKAISRELYEYCIKEGYADKNLIAKWKKQGYENLCCLRCIQTRDTNFGTNCICRVPKSKLEVGRIIECTHCGCRGCSG", "length": 144, "header": "sp|Q2NKU3-1|BUD31_BOVIN Isoform 1 of Protein BUD31 homolog OS=Bos taurus OX=9913 GN=BUD31 PE=2 SV=1 CANONICAL=Q2NKU3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TIV3-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKU3/entry#A0AAA9TIV3-1", "sequence": { "sequence": "ASRLRRLRRRRLELTPEPEIPRARLLPPGQFPAPPPRHPGPSQRAAPPREPRPSGRPGGPTHRLSPGSPRAAGQQSPSQPPPREAREPANPPRRAVRTKGDSGAGILHRQGCGHLRTLVTAGGQGSDVCVGPEGDLNSPTGTGSGLWTRRSKFLQTIFWEKMPKVKRSRKAPPDGWELIEPTLDELDQKMREAETEPHEGKRKVESLWPIFRIHHQKTRYIFDLFYKRKAISRELYEYCIKEGYADKNLIAKWKKQGYENLCCLRCIQTRDTNFGTNCICRVPKSKLEVGRIIECTHCGCRGCSG", "length": 305, "header": "tr|A0AAA9TIV3-1|BUD31_BOVIN Computationally mapped isoform of Protein BUD31 homolog OS=Bos taurus OX=9913 GN=BUD31 PE=2 SV=1 CANONICAL=Q2NKU3-1" }, "locus": { "chromosome": "25", "start_pos": 36991409, "end_pos": 36983261, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109672.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109672.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097080.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097080.1" } ] } }, { "isoform_ac": "A0AAF6ZD28-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKU3/entry#A0AAF6ZD28-1", "sequence": { "sequence": "MPKVKRSRKAPPDGWELIEPTLDELDQKMREELYEYCIKEGYADKNLIAKWKKQGYENLCCLRCIQTRDTNFGTNCICRVPKSKLEVGRIIECTHCGCRGCSG", "length": 103, "header": "tr|A0AAF6ZD28-1|BUD31_BOVIN Computationally mapped isoform of Protein BUD31 homolog OS=Bos taurus OX=9913 GN=BUD31 PE=2 SV=1 CANONICAL=Q2NKU3-1" }, "locus": { "chromosome": "25", "start_pos": 36989213, "end_pos": 36983261, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037140.4", "url": "https://www.ensembl.org/id/ENSBTAT00000037140.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036979.3", "url": "https://www.ensembl.org/id/ENSBTAP00000036979.3" } ] } }, { "isoform_ac": "Q2NKU3-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKU3/entry#Q2NKU3-1", "sequence": { "sequence": "MPKVKRSRKAPPDGWELIEPTLDELDQKMREAETEPHEGKRKVESLWPIFRIHHQKTRYIFDLFYKRKAISRELYEYCIKEGYADKNLIAKWKKQGYENLCCLRCIQTRDTNFGTNCICRVPKSKLEVGRIIECTHCGCRGCSG", "length": 144, "header": "sp|Q2NKU3-1|BUD31_BOVIN Isoform 1 of Protein BUD31 homolog OS=Bos taurus OX=9913 GN=BUD31 PE=2 SV=1 CANONICAL=Q2NKU3-1" }, "locus": { "chromosome": "25", "start_pos": 36989213, "end_pos": 36983261, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080736.1", "url": "https://www.ensembl.org/id/ENSBTAT00000080736.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061709.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061709.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:533977", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533977", "resource": "KEGG Pathway" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1U3I4-1", "protein_name": "Protein BUD31 homolog", "gene_name": "BUD31", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPKVKRSRKAPPDGWELIEPTLDELDQKMREELYEYCIKEGYADKNLIAKWKKQGYENLCCLRCIQTRDTNFGTNCICRVPKSKLEVGRIIECTHCGCRGCSG", "length": 103 }, "evidence": [ { "id": "Q2NKU3", "url": "https://omabrowser.org/oma/group/Q2NKU3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "E1BV47-1", "protein_name": "Protein BUD31 homolog", "gene_name": "BUD31", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPKVKRSRKPPPDGWELIEPTLDELDQKMREAETEPHEGKRKVESLWPIFRIHHQKTRYIFDLFYKRKAISRELYEYCIKEGYADKNLIAKWKKQGYENLCCLRCIQTRDTNFGTNCICRVPKSKLEVGRIIECTHCGCRGCSG", "length": 144 }, "evidence": [ { "id": "Q2NKU3", "url": "https://omabrowser.org/oma/group/Q2NKU3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3I387-1", "protein_name": "Protein BUD31 homolog", "gene_name": "Bud31", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPKVKRSRKAPPDGWELIEPTLDELDQKMREAETEPHEGKRKVESLWPIFRIHHQKTRYIFDLFYKRKAISRELYEYCIKEGYADKNLIAKWKKQGYENLCCLRCIQTRDTNFGTNCICRVPKSKLEVGRIIECTHCGCRGCSG", "length": 144 }, "evidence": [ { "id": "Q2NKU3", "url": "https://omabrowser.org/oma/group/Q2NKU3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O49553-1", "protein_name": "G10 family protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MPKVKTNRVKYPEGWELIEPTLRELDAKMREAETDSHDGKRKCETLWPIFKVSHQRSRYVYDLYYRREEISKELYEFCLDQGYADRSLIAKWKKSGYERLCCLRCIQPRDHNYGTTCVCRVPKHLREEKVVECVHCGCQGCASGD", "length": 145 }, "evidence": [ { "id": "Q2NKU3", "url": "https://omabrowser.org/oma/group/Q2NKU3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "O70454-1", "protein_name": "Protein BUD31 homolog", "gene_name": "Bud31", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKVKRSRKAPPDGWELIEPTLDELDQKMREAETEPHEGKRKVESLWPIFRIHHQKTRYIFDLFYKRKAISRELYEYCIKEGYADKNLIAKWKKQGYENLCCLRCIQTRDTNFGTNCICRVPKSKLEVGRIIECTHCGCRGCSG", "length": 144 }, "evidence": [ { "id": "Q2NKU3", "url": "https://omabrowser.org/oma/group/Q2NKU3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O97454-1", "protein_name": "Protein BUD31 homolog", "gene_name": "l(1)10Bb", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPKVRRSRKPPPDGWELIEPTLEELEQKMREAETEPHEGKRITESLWPIFKIHHQKTRYIYDLFYRRKAISRELYDYCLKEKIADGNLIAKWKKSGYENLCCLRCIQTRDTNFGTNCICRVPKCKLEEGRIVECVHCGCRGCSG", "length": 144 }, "evidence": [ { "id": "Q2NKU3", "url": "https://omabrowser.org/oma/group/Q2NKU3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P25337-1", "protein_name": "Pre-mRNA-splicing factor BUD31", "gene_name": "BUD31", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MPRIKTRRSKPAPDGFEKIKPTLTDFEIQLRDAQKDKSSKLAAKSNEQLWEIMQLHHQRSRYIYTLYYKRKAISKDLYDWLIKEKYADKLLIAKWRKTGYEKLCCLRCIQKNETNNGSTCICRVPRAQLEEEARKKGTQVSFHQCVHCGCRGCASTD", "length": 157 }, "evidence": [ { "id": "Q2NKU3", "url": "https://omabrowser.org/oma/group/Q2NKU3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P41223-1", "protein_name": "Protein BUD31 homolog", "gene_name": "BUD31", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPKVKRSRKAPPDGWELIEPTLDELDQKMREAETEPHEGKRKVESLWPIFRIHHQKTRYIFDLFYKRKAISRELYEYCIKEGYADKNLIAKWKKQGYENLCCLRCIQTRDTNFGTNCICRVPKSKLEVGRIIECTHCGCRGCSG", "length": 144 }, "evidence": [ { "id": "Q2NKU3", "url": "https://omabrowser.org/oma/group/Q2NKU3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6PGH1-1", "protein_name": "Protein BUD31 homolog", "gene_name": "Bud31", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKVKRSRKAPPDGWELIEPTLDELDQKMREAETEPHEGKRKVESLWPIFRIHHQKTRYIFDLFYKRKAISRELYEYCIKEGYADKNLIAKWKKQGYENLCCLRCIQTRDTNFGTNCICRVPKSKLEVGRIIECTHCGCRGCSG", "length": 144 }, "evidence": [ { "id": "Q2NKU3", "url": "https://omabrowser.org/oma/group/Q2NKU3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "Q2NKU3", "url": "https://www.uniprot.org/uniprotkb/Q2NKU3" } ], "pmid": "" }, { "name": "nuclear receptor binding", "id": "GO:0016922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016922", "evidence": [ { "database": "UniProtKB", "id": "Q2NKU3", "url": "https://www.uniprot.org/uniprotkb/Q2NKU3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "Q2NKU3", "url": "https://www.uniprot.org/uniprotkb/Q2NKU3" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "Q2NKU3", "url": "https://www.uniprot.org/uniprotkb/Q2NKU3" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2NKU3", "url": "https://www.uniprot.org/uniprotkb/Q2NKU3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "Q2NKU3", "url": "https://www.uniprot.org/uniprotkb/Q2NKU3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NKU3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 144, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NKU3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NKU3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2NKU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKU3" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Nuclear localization signal", "eco_id": "ECO_0000255", "start_pos": 2, "end_pos": 10, "start_aa": "Pro", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBV6-1", "uniprot_ac": "Q2TBV6", "uniprot_id": "CC124_BOVIN", "mass": { "chemical_mass": 26005.0, "monoisotopic_mass": 26005.0 }, "refseq": { "ac": "NP_001033612", "name": "coiled-coil domain-containing protein 124", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033612" }, "gene_names": [ { "name": "CCDC124", "type": "recommended", "evidence": [ { "id": "Q2TBV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBV6" } ] }, { "name": "CCDC124", "type": "synonym", "evidence": [ { "id": "NP_001033612", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033612" } ] } ], "protein_names": [ { "name": "Coiled-coil domain-containing protein 124", "type": "recommended", "evidence": [ { "id": "Q2TBV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBV6/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain-containing protein 124", "type": "synonym", "evidence": [ { "id": "NP_001033612", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033612" } ] } ], "function": [ { "annotation": "Ribosome-binding protein involved in ribosome hibernation: associates with translationally inactive ribosomes and stabilizes the nonrotated conformation of the 80S ribosome, thereby promoting ribosome preservation and storage. Also required for proper progression of late cytokinetic stages.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV6", "url": "https://www.uniprot.org/uniprotkb/Q2TBV6#function" }, { "database": "UniProtKB", "id": "Q96CT7", "url": "https://www.uniprot.org/uniprotkb/Q96CT7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBV6", "url": "https://www.uniprot.org/uniprotkb/Q2TBV6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC124", "url": "https://www.uniprot.org/uniprotkb/Q2TBV6", "locus": { "chromosome": "7", "start_pos": 5230983, "end_pos": 5241721, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004604", "url": "https://www.ensembl.org/id/ENSBTAG00000004604" } ] } } ], "crossref": [ { "id": "Q2TBV6", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBV6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004604", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004604", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510778", "url": "https://www.ncbi.nlm.nih.gov/gene/510778", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054414", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054414", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510778", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510778", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FEERMMP", "url": "https://omabrowser.org/oma/group/FEERMMP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBV6", "url": "https://www.orthodb.org/?gene=Q2TBV6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21680", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21680", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21680:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21680:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06244", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06244", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033612", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ36-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AIH6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AIH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AIH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AIH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBV6", "url": "https://www.uniprot.org/uniprotkb/Q2TBV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBV6-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPKKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWRDEDKHVMRKEQRKEEKEKRRLEQLERKKETQRLLEEEDSKLKGGKAPRVAASSKVTRAQIEETLRRDHQHKESPDPAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVTEEAVDRHPERRMRAAYTAFEEAQLPRLKQENPNMRLSQLKQMLKKEWLRSPDNPMNQRAVPFNTPK", "length": 223, "header": "sp|Q2TBV6-1|CC124_BOVIN Isoform 1 of Coiled-coil domain-containing protein 124 OS=Bos taurus OX=9913 GN=CCDC124 PE=2 SV=1 CANONICAL=Q2TBV6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TJ36-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV6/entry#A0AAA9TJ36-1", "sequence": { "sequence": "MWEPSSCVQTAFLLSYPSGRLEVRGPVRVLRNPSSGALSPVTGALPAHRPSPRHRGWMAELQAVGGQAGMPVAQGSVGVRGGPQQNISSLKPHRTTNEPEPRAVPGAVEGQQPRTSTLGYTSPRPAGIRAFLGSQRGISPSLCDTQLGTLQQCLPKEEKEKRRLEQLERKKETQRLLEEEDSKLKGGKAPRVAASSKVTRAQIEETLRRDHQHKESPDPAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVTEEAVDRHPERRMRAAYTAFEEAQLPRLKQENPNMRLSQLKQMLKKEWLRSPDNPMNQRAVPFNTPK", "length": 326, "header": "tr|A0AAA9TJ36-1|CC124_BOVIN Computationally mapped isoform of Coiled-coil domain-containing protein 124 OS=Bos taurus OX=9913 GN=CCDC124 PE=2 SV=1 CANONICAL=Q2TBV6-1" }, "locus": { "chromosome": "7", "start_pos": 5233348, "end_pos": 5231231, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101226.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101226.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097177.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097177.1" } ] } }, { "isoform_ac": "A0AAF7AIH6-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV6/entry#A0AAF7AIH6-1", "sequence": { "sequence": "GQGGGGCQEAEGAGRCVLEGRGQTRHEEGAAQEPRAVPGAVEGQQPRTSTLGYTSPRPAGIRAFLGSQRGISPSLCDTQLGTLQQCLPKVCWPIKEPLPQLADGFRPSSGSCRLWNPEEKEKRRLEQLERKKETQRLLEEEDSKLKGGKAPRVAASSKVTRAQIEETLRRDHQHKESPDPAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVTEEAVDRHPERRMRAAYTAFEEAQLPRLKQENPNMRLSQLKQMLKKEWLRSPDNPMNQRAVPFNTPK", "length": 287, "header": "tr|A0AAF7AIH6-1|CC124_BOVIN Computationally mapped isoform of Coiled-coil domain-containing protein 124 OS=Bos taurus OX=9913 GN=CCDC124 PE=2 SV=1 CANONICAL=Q2TBV6-1" }, "locus": { "chromosome": "7", "start_pos": 5236114, "end_pos": 5231231, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069646.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069646.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069472.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069472.2" } ] } }, { "isoform_ac": "Q2TBV6-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV6/entry#Q2TBV6-1", "sequence": { "sequence": "MPKKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWRDEDKHVMRKEQRKEEKEKRRLEQLERKKETQRLLEEEDSKLKGGKAPRVAASSKVTRAQIEETLRRDHQHKESPDPAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVTEEAVDRHPERRMRAAYTAFEEAQLPRLKQENPNMRLSQLKQMLKKEWLRSPDNPMNQRAVPFNTPK", "length": 223, "header": "sp|Q2TBV6-1|CC124_BOVIN Isoform 1 of Coiled-coil domain-containing protein 124 OS=Bos taurus OX=9913 GN=CCDC124 PE=2 SV=1 CANONICAL=Q2TBV6-1" }, "locus": { "chromosome": "7", "start_pos": 5236176, "end_pos": 5231231, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006040.5", "url": "https://www.ensembl.org/id/ENSBTAT00000006040.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006040.3", "url": "https://www.ensembl.org/id/ENSBTAP00000006040.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 141, "end_pos": 141, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV6", "url": "https://www.uniprot.org/uniprotkb/Q2TBV6" } ], "site_lbl": "Ser141" }, { "start_pos": 194, "end_pos": 194, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV6", "url": "https://www.uniprot.org/uniprotkb/Q2TBV6" } ], "site_lbl": "Ser194" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510778", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510778", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AF79-1", "protein_name": "Coiled-coil domain containing 124", "gene_name": "CCDC124", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPKKFQGENTKSAAARARKAEAKAAADAKRQQELEDAYWKDDDKHVMRKEQRKEEREKRRLEQLERKKELQRLLEEEDSKLKGKSPKQATPGKVTRAQIEETIRKDQQQKENADTAEKEKTHLEVPLEENINRRVLEEGTVEARTIEDAIAVLRYVANDVDRHPERRMKAAFTAFEEVNLPRLKQENPNMRLSQLKQLLKKEWMKSPENPMNQRHKAYNSQK", "length": 222 }, "evidence": [ { "id": "Q2TBV6", "url": "https://omabrowser.org/oma/group/Q2TBV6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZUL1-1", "protein_name": "Coiled-coil domain containing 124", "gene_name": "Ccdc124", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKKFQGENSKSAAARARRAEAKAAADAKKQKELEDAYWKDEDKHVMRKEQRKEEKEKRRLEQLERKKETQRLLEEEDSRLKGGKAPRVAPAKVTRAQIEDSLRKEQRAEPVEKAKSHLELPLEENLNRRLQEEGSVEARTVEDAIAVLSVAEEADRHPERRMRAAFTAFEEVQLPRLKQENPNMRLSQLKQLLKKEWLRSPDNPMNQRALPFNAPK", "length": 217 }, "evidence": [ { "id": "Q2TBV6", "url": "https://omabrowser.org/oma/group/Q2TBV6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S924-1", "protein_name": "Coiled-coil domain containing 124", "gene_name": "CCDC124", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPKKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDEDKHVMRKEQRKEEKEKRRLEQLERKKETQRLLEEEDSKLKGGKAPRVAAPSKVTRAQIEETLRRDHQHKEASDAAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSLAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQLLKKEWLRSPDNPMNQRVMPFNAPK", "length": 223 }, "evidence": [ { "id": "Q2TBV6", "url": "https://omabrowser.org/oma/group/Q2TBV6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H4B6-1", "protein_name": "Coiled-coil domain-containing protein 124", "gene_name": "Ccdc124", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPKKFQGENSKSAAARARRAEAKAAADAKKQKELEDAYWKDEDKHVMRKEQRKEEKEKRRLEQLERKKETQRLLEEEDSRLKGGKAPRVAPAKVTRAQIEDSLRREQRVESVEKAKSHLELPLEENLNRRLQEEGSLEARTVEDAIAVLSVAEDADRHPERRMRAAFTAFEEVQLPRLKQENPNMRLSQLKQLLKKEWLRSPDNPMNQRVLPFNTPK", "length": 217 }, "evidence": [ { "id": "Q2TBV6", "url": "https://omabrowser.org/oma/group/Q2TBV6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q54GW3-1", "protein_name": "Coiled-coil domain-containing protein 124 homolog", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGGKKFGTNSKAEEARSKKAEVKKNENEKKQRDKEDKMWEETDTKILDKQKKQKEKEEKAREDAKKKQEAKELLQQEDKEIKERYGKPSDTKVTRFEIQQKRDKEQKQREKELASRPSDPRVVVVPTTTTTTTTTTTTTTGSDDHEEEDFNLEENMNHILREQRLKDGKDVIDARDINEAIGALSGNDGKEQHPERRMKAAFNAYEEENLPVLRKENPSLRLTQVKQLLWKNWLKAPENPFNQVGSQ", "length": 247 }, "evidence": [ { "id": "Q2TBV6", "url": "https://omabrowser.org/oma/group/Q2TBV6/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6PHE8-1", "protein_name": "Coiled-coil domain-containing protein 124", "gene_name": "ccdc124", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPKKFQGENSKSATARARKAEAKAVADARKQKELEDALWEDNDKRVVKKEQRKDDKERKRLEALERKRENQRLLEEEDSKIKGKQTKEGPSKVTRAQIEETLQSKQNVKEIKEKEKSHLDVPLEENVNRIVPEEGTVEARTIEDAIAVLSTKEDLDRHPERRMKAAYTAFEEANMPRVKMENPNMRLSQLKQQLKKEWTKSPENPLNQRAASYNTK", "length": 216 }, "evidence": [ { "id": "Q2TBV6", "url": "https://omabrowser.org/oma/group/Q2TBV6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q96CT7-1", "protein_name": "Coiled-coil domain-containing protein 124", "gene_name": "CCDC124", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPKKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQLLKKEWLRSPDNPMNQRAVPFNAPK", "length": 223 }, "evidence": [ { "id": "Q2TBV6", "url": "https://omabrowser.org/oma/group/Q2TBV6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D8X2-1", "protein_name": "Coiled-coil domain-containing protein 124", "gene_name": "Ccdc124", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKKFQGENSKSAAARARRAEAKAAADAKKQKELEDAYWKDEDKHVMRKEQRKEEKEKRRLEQLERKKETQRLLEEEDSRLKGGKAPRVAPAKVTRAQIEDSLRREQRAEPVEKAKSHLELPLEENLNRRLQEEGSVEARTVEDAIAVLSVAEEADRHPERRMRAAFTAFEEVQLPRLKQENPNMRLSQLKQLLKKEWLRSPDNPMNQRALPFNAPK", "length": 217 }, "evidence": [ { "id": "Q2TBV6", "url": "https://omabrowser.org/oma/group/Q2TBV6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VE08-1", "protein_name": "Coiled-coil domain-containing protein", "gene_name": "Dmel\\CG6013", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPKKMGINSKAVEARERKEATKKATQEKKSKEAEDRLWRDDDKNLAKKQQRKDEEERKRAEAAKRKAEAKALLDQEMSSINTQRKQPLAKINRQMILEEMEKKQRVIEAINEANKPMAARVVVQNHIEENLNRSMADTDVASNIDEAIVVLSVNDSEEDKHPEKRMRAAYKTFEANNLPRIKAENPSLRMSQWKQLLMKEWNKSPDNPFNQAR", "length": 213 }, "evidence": [ { "id": "Q2TBV6", "url": "https://omabrowser.org/oma/group/Q2TBV6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV6", "url": "https://www.uniprot.org/uniprotkb/Q2TBV6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV6", "url": "https://www.uniprot.org/uniprotkb/Q2TBV6" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV6", "url": "https://www.uniprot.org/uniprotkb/Q2TBV6" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV6", "url": "https://www.uniprot.org/uniprotkb/Q2TBV6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV6", "url": "https://www.uniprot.org/uniprotkb/Q2TBV6" } ], "pmid": "" }, { "name": "transcription by RNA polymerase II", "id": "GO:0006366", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV6", "url": "https://www.uniprot.org/uniprotkb/Q2TBV6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBV6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 223, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBV6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBV6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 141, 194 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KU2-1", "uniprot_ac": "Q32KU2", "uniprot_id": "PRS37_BOVIN", "mass": { "chemical_mass": 26316.0, "monoisotopic_mass": 26316.0 }, "refseq": { "ac": "NP_001035659", "name": "probable inactive serine protease 37 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035659" }, "gene_names": [ { "name": "PRSS37", "type": "recommended", "evidence": [ { "id": "Q32KU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KU2" } ] }, { "name": "PRSS37", "type": "synonym", "evidence": [ { "id": "NP_001035659", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035659" } ] }, { "name": "TRYX2", "type": "synonym", "evidence": [ { "id": "NP_001035659", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035659" }, { "id": "Q32KU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KU2" } ] } ], "protein_names": [ { "name": "Probable inactive serine protease 37", "type": "recommended", "evidence": [ { "id": "Q32KU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KU2/entry#names_and_taxonomy" } ] }, { "name": "Probable inactive trypsin-X2", "type": "synonym", "evidence": [ { "id": "Q32KU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KU2/entry#names_and_taxonomy" } ] }, { "name": "probable inactive serine protease 37 precursor", "type": "synonym", "evidence": [ { "id": "NP_001035659", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035659" } ] }, { "name": "probable inactive serine protease 37", "type": "synonym", "evidence": [ { "id": "NP_001035659", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035659" } ] }, { "name": "probable inactive trypsin-X2", "type": "synonym", "evidence": [ { "id": "NP_001035659", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035659" } ] }, { "name": "protease, serine 37", "type": "synonym", "evidence": [ { "id": "NP_001035659", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035659" } ] } ], "function": [ { "annotation": "Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system.", "evidence": [ { "database": "UniProtKB", "id": "Q32KU2", "url": "https://www.uniprot.org/uniprotkb/Q32KU2#function" }, { "database": "UniProtKB", "id": "A4D1T9", "url": "https://www.uniprot.org/uniprotkb/A4D1T9#function" }, { "database": "UniProtKB", "id": "Q9DAA4", "url": "https://www.uniprot.org/uniprotkb/Q9DAA4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KU2", "url": "https://www.uniprot.org/uniprotkb/Q32KU2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRSS37", "url": "https://www.uniprot.org/uniprotkb/Q32KU2", "locus": { "chromosome": "4", "start_pos": 105071256, "end_pos": 105077184, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018442", "url": "https://www.ensembl.org/id/ENSBTAG00000018442" } ] } } ], "crossref": [ { "id": "Q32KU2", "url": "https://alphafold.ebi.ac.uk/entry/Q32KU2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018442", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018442", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540062", "url": "https://www.ncbi.nlm.nih.gov/gene/540062", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540062", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540062", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DKDCQKT", "url": "https://omabrowser.org/oma/group/DKDCQKT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32KU2", "url": "https://www.orthodb.org/?gene=Q32KU2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24271", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24271:SF61", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271:SF61", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035659", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TLB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLB1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KU2", "url": "https://www.uniprot.org/uniprotkb/Q32KU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KU2-1", "url": "https://www.uniprot.org/uniprotkb/Q32KU2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKFTFCLTVLAGTFFSAHSSVQKDDPSPYLVYLKSHFNPCVGVLIKSNWVLAPAHCYLPNLKVMLGNLRIRIRDGTEQTINPIQIIRYWNHSHTAPQDDLMLIRLAKPAILNEKVQPIALATSTVKPGTICMLSGLDWSQNNNGRHPDLRQNLEAPVMSDTACQETEQGKSHRNSICVKFLKVFSRIFGELAVATVICKNKLQGIEVGHFMGGDVGIYTNVQKYVSWIESTTKDK", "length": 235, "header": "sp|Q32KU2-1|PRS37_BOVIN Isoform 1 of Probable inactive serine protease 37 OS=Bos taurus OX=9913 GN=PRSS37 PE=2 SV=1 CANONICAL=Q32KU2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TLB1-1", "url": "https://www.uniprot.org/uniprotkb/Q32KU2/entry#A0AAA9TLB1-1", "sequence": { "sequence": "IKWTFFSAHSSVQKDDPSPYLVYLKSHFNPCVGVLIKSNWVLAPAHCYLPNLKVMLGNLRIRIRDGTEQTINPIQIIRYWNHSHTAPQDDLMLIRLAKPAILNEKVQPIALATSTVKPGTICMLSGLDWSQNNNGRHPDLRQNLEAPVMSDTACQETEQGKSHRNSICVKFLKVFSRIFGELAVATVICKNKLQGIEVGHFMGGDVGIYTNVQKYVSWIESTTKDK", "length": 226, "header": "tr|A0AAA9TLB1-1|PRS37_BOVIN Computationally mapped isoform of Probable inactive serine protease 37 OS=Bos taurus OX=9913 GN=PRSS37 PE=2 SV=1 CANONICAL=Q32KU2-1" }, "locus": { "chromosome": "4", "start_pos": 105075505, "end_pos": 105071375, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133820.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133820.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099223.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099223.1" } ] } }, { "isoform_ac": "Q32KU2-1", "url": "https://www.uniprot.org/uniprotkb/Q32KU2/entry#Q32KU2-1", "sequence": { "sequence": "MKFTFCLTVLAGTFFSAHSSVQKDDPSPYLVYLKSHFNPCVGVLIKSNWVLAPAHCYLPNLKVMLGNLRIRIRDGTEQTINPIQIIRYWNHSHTAPQDDLMLIRLAKPAILNEKVQPIALATSTVKPGTICMLSGLDWSQNNNGRHPDLRQNLEAPVMSDTACQETEQGKSHRNSICVKFLKVFSRIFGELAVATVICKNKLQGIEVGHFMGGDVGIYTNVQKYVSWIESTTKDK", "length": 235, "header": "sp|Q32KU2-1|PRS37_BOVIN Isoform 1 of Probable inactive serine protease 37 OS=Bos taurus OX=9913 GN=PRSS37 PE=2 SV=1 CANONICAL=Q32KU2-1" }, "locus": { "chromosome": "4", "start_pos": 105076768, "end_pos": 105071375, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024541.3", "url": "https://www.ensembl.org/id/ENSBTAT00000024541.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024541.2", "url": "https://www.ensembl.org/id/ENSBTAP00000024541.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540062", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540062", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MG83-1", "protein_name": "Probable inactive serine protease 37", "gene_name": "Prss37", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKLYFYLVILAGTALFTHSSVQKEDYAPYIVYLKSNFNPCVGVLIKAQWVLAPSHCYLPNLRVMLGNLKSRVRDGTEQTIHPIQIIRYWNFSHTAPQDDLMLIKLATPAVFNHKVQVIPLATANVRPGTVCSLSGLDWSQENTGRHPDLRQTLEAPVMTDKDCQKTEQGSSHRNSLCIKFVKVFSRIFGEVAVATAICKGKLQGIEVGHFMGGDVGIYTNVYTYIPWIERTTKEKMH", "length": 237 }, "evidence": [ { "id": "Q32KU2", "url": "https://omabrowser.org/oma/group/Q32KU2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0ABK0M2Y3-1", "protein_name": "Serine protease 37", "gene_name": "Prss37", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGGAKRSIKCPLGGSEQTIKGMLSLSQGKESCSSQLCPQKFFKKGTALFTHSSVQKEDHAPYLAYLKSNFNPCVGVLIKASWVLAPSHCYLPNLRVMLGNFKSRVRDGTEQTIYPIQIIRYWNYSHTAPQDDLMLIKLAKPATFNNKVQVLPIATTNVRPGTICTLSGLDWSQENNGRHPDLRQNLEAPVMTDKDCQKTQQGSNHRNSLCVKFGKVFSRIFGEVAVATVICKNKLQGIEVGHFMGGDVGIYTNIYSYVPWIEKTTKEKMK", "length": 270 }, "evidence": [ { "id": "Q32KU2", "url": "https://omabrowser.org/oma/group/Q32KU2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A4D1T9-1", "protein_name": "Probable inactive serine protease 37", "gene_name": "PRSS37", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKYVFYLGVLAGTFFFADSSVQKEDPAPYLVYLKSHFNPCVGVLIKPSWVLAPAHCYLPNLKVMLGNFKSRVRDGTEQTINPIQIVRYWNYSHSAPQDDLMLIKLAKPAMLNPKVQPLTLATTNVRPGTVCLLSGLDWSQENSGRHPDLRQNLEAPVMSDRECQKTEQGKSHRNSLCVKFVKVFSRIFGEVAVATVICKDKLQGIEVGHFMGGDVGIYTNVYKYVSWIENTAKDK", "length": 235 }, "evidence": [ { "id": "Q32KU2", "url": "https://omabrowser.org/oma/group/Q32KU2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "I3LE93-1", "protein_name": "Serine protease 37", "gene_name": "PRSS37", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAFILYLSVLAGTFFSAHSSVQKDDHAPYLVYLKSHFNPCVGVLIKSNWVLAPAHCYLPNLKVMLGNFRIRVRDGTEQTINPIQIIRYWNHSHSAPQDDLMLIKLAKPATLNHKVQTLPLATSTVRPGTNCLLSGLDWSQDNNSRHPDLRQNLEAPVMADKDCQKTKQGKSHRNSLCVKFVKVFSRIFGEVAVATVICQNKLQGIEVGQFMGGDVGIYTNVQKYVTWIENITKNK", "length": 235 }, "evidence": [ { "id": "Q32KU2", "url": "https://omabrowser.org/oma/group/Q32KU2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9DAA4-1", "protein_name": "Probable inactive serine protease 37", "gene_name": "Prss37", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKLIIYLTILAGTALVTHSSVQKEDHAPYLAYLKSNFNPCVGVLIKASWVLAPSHCYLPNLRVMLGNFKSRVRDGTEQTIYPIQIIRYWNYSHTAPQDDLMLIKLAKPATFNHKVQVLPIATTNVRPGTVCTLSGLDWSQENNGRHPDLRQNLEAPVMTDKDCQKTQQGSSHRNSLCVRFVKVFSRIFGEVAVATVICKNKLQGIEVGHFMGGDVGIYTNIYSYVPWIEKTTKEKMT", "length": 237 }, "evidence": [ { "id": "Q32KU2", "url": "https://omabrowser.org/oma/group/Q32KU2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "positive regulation of acrosome reaction", "id": "GO:2000344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000344", "evidence": [ { "database": "UniProtKB", "id": "Q32KU2", "url": "https://www.uniprot.org/uniprotkb/Q32KU2" } ], "pmid": "" }, { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "Q32KU2", "url": "https://www.uniprot.org/uniprotkb/Q32KU2" } ], "pmid": "" }, { "name": "binding of sperm to zona pellucida", "id": "GO:0007339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007339", "evidence": [ { "database": "UniProtKB", "id": "Q32KU2", "url": "https://www.uniprot.org/uniprotkb/Q32KU2" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "Q32KU2", "url": "https://www.uniprot.org/uniprotkb/Q32KU2" } ], "pmid": "" }, { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "Q32KU2", "url": "https://www.uniprot.org/uniprotkb/Q32KU2" } ], "pmid": "" }, { "name": "positive regulation of fertilization", "id": "GO:1905516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905516", "evidence": [ { "database": "UniProtKB", "id": "Q32KU2", "url": "https://www.uniprot.org/uniprotkb/Q32KU2" } ], "pmid": "" }, { "name": "regulation of protein processing", "id": "GO:0070613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070613", "evidence": [ { "database": "UniProtKB", "id": "Q32KU2", "url": "https://www.uniprot.org/uniprotkb/Q32KU2" } ], "pmid": "" }, { "name": "positive regulation of reproductive process", "id": "GO:2000243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000243", "evidence": [ { "database": "UniProtKB", "id": "Q32KU2", "url": "https://www.uniprot.org/uniprotkb/Q32KU2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q32KU2", "url": "https://www.uniprot.org/uniprotkb/Q32KU2" } ], "pmid": "" }, { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "Q32KU2", "url": "https://www.uniprot.org/uniprotkb/Q32KU2" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q32KU2", "url": "https://www.uniprot.org/uniprotkb/Q32KU2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "Q32KU2", "url": "https://www.uniprot.org/uniprotkb/Q32KU2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KU2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 235, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KU2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KU2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32KU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KU2" }, { "id": "PRU00274", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00274" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000255", "start_pos": 20, "end_pos": 233, "start_aa": "Ser", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0C8-1", "uniprot_ac": "Q3T0C8", "uniprot_id": "PDLI2_BOVIN", "mass": { "chemical_mass": 37671.0, "monoisotopic_mass": 37671.0 }, "refseq": { "ac": "NP_001029602", "name": "PDZ and LIM domain protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029602" }, "gene_names": [ { "name": "PDLIM2", "type": "recommended", "evidence": [ { "id": "Q3T0C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ] }, { "name": "PDLIM2", "type": "synonym", "evidence": [ { "id": "NP_001029602", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029602" } ] } ], "protein_names": [ { "name": "PDZ and LIM domain protein 2", "type": "recommended", "evidence": [ { "id": "Q3T0C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8/entry#names_and_taxonomy" } ] }, { "name": "PDZ and LIM domain 2 (mystique)", "type": "synonym", "evidence": [ { "id": "NP_001029602", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029602" } ] }, { "name": "PDZ and LIM domain protein 2", "type": "synonym", "evidence": [ { "id": "NP_001029602", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029602" } ] } ], "function": [ { "annotation": "Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PDLIM2", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8", "locus": { "chromosome": "8", "start_pos": 69895316, "end_pos": 69882096, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007369", "url": "https://www.ensembl.org/id/ENSBTAG00000007369" } ] } } ], "crossref": [ { "id": "Q3T0C8", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0C8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007369", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007369", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06753", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06753", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09449", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09449", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512907", "url": "https://www.ncbi.nlm.nih.gov/gene/512907", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031847", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031847", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050604", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050604", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512907", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512907", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MRGHFWF", "url": "https://omabrowser.org/oma/group/MRGHFWF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0C8", "url": "https://www.orthodb.org/?gene=Q3T0C8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24214", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24214", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24214:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24214:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15936", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15936", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029602", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TLV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AAD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AAD1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0C8-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALTVDVVGPAPWGFRISGGRDFHTPIMVTKVTERGKAEAADLRPGDIIVSINGESAKDMLHAEAQSKIRQSPSPLRLQLDRPQAASPGQANGESSLEVLATRFQSSRRTHTDSQASLSPRPCSPFFTLPPTSPQAPTGEVVTSHSFQSLAYSLEPASADHLYYGGRRGSRQASLSPAGDSAVLVLPPPPSPGARSSSSRLSVVSEGESHLLREDSEVFKMLQENREARMAPRQSSSFRLLQEALEAEERGGTPAYLPSSLSPQSSLPTSRALASPPKLHTCEKCNTSIANQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQRYSAPPTLNSQA", "length": 348, "header": "sp|Q3T0C8-1|PDLI2_BOVIN Isoform 1 of PDZ and LIM domain protein 2 OS=Bos taurus OX=9913 GN=PDLIM2 PE=2 SV=1 CANONICAL=Q3T0C8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TLV5-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8/entry#A0AAA9TLV5-1", "sequence": { "sequence": "VRQTAAAAAGAAASPCLPPSLPFALGPCRPARQVSGSQVSAPTCARGAWLASSPAPAPWPFCAPAAPWVPEPLCARPLPAASPAVGSPPGAGLSPPGRSYSSPQAPTGEVVTSHSFQSLAYSLEPASADHLYYGGRRGSRQASLSPAGDSAVLVLPPPPSPGARSSSSRLSVVSEGESHLLREDSEVFKMLQENREARMAPRQSSSFRLLQEALEAEERGGTPAYLPSSLSPQSSLPTSRALASPPKLHTCEKCNTSIANQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQRYSAPPTLNSQA", "length": 317, "header": "tr|A0AAA9TLV5-1|PDLI2_BOVIN Computationally mapped isoform of PDZ and LIM domain protein 2 OS=Bos taurus OX=9913 GN=PDLIM2 PE=2 SV=1 CANONICAL=Q3T0C8-1" }, "locus": { "chromosome": "8", "start_pos": 69894952, "end_pos": 69882164, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134294.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134294.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099436.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099436.1" } ] } }, { "isoform_ac": "A0AAF7AAD1-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8/entry#A0AAF7AAD1-1", "sequence": { "sequence": "MALTVDVVGPAPWGFRISGGRDFHTPIMVTKVTERGKAEAADLRPGDIIVSINGESAKDMLHAEAQSKIRQSPSPLRLQLDRPQAASPGQANGESSLEVLATRFQSSRRTHTDSQASLSPRPCSPFFTLPPTSPQAPTGEVVTSHSFQSLAYSLEPASADHLYYGGRRGSRQASLSPAGDSAVLVLPPPPSPGARSSSSRLSVVSEGESHLLREDSEVFKMLQENREARMAPRQSSSFRLLQEALEAEERGTRPSVSRRGGTAILAATPVLTAG", "length": 274, "header": "tr|A0AAF7AAD1-1|PDLI2_BOVIN Computationally mapped isoform of PDZ and LIM domain protein 2 OS=Bos taurus OX=9913 GN=PDLIM2 PE=2 SV=1 CANONICAL=Q3T0C8-1" }, "locus": { "chromosome": "8", "start_pos": 69894848, "end_pos": 69883693, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066358.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066358.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065726.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065726.2" } ] } }, { "isoform_ac": "Q3T0C8-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8/entry#Q3T0C8-1", "sequence": { "sequence": "MALTVDVVGPAPWGFRISGGRDFHTPIMVTKVTERGKAEAADLRPGDIIVSINGESAKDMLHAEAQSKIRQSPSPLRLQLDRPQAASPGQANGESSLEVLATRFQSSRRTHTDSQASLSPRPCSPFFTLPPTSPQAPTGEVVTSHSFQSLAYSLEPASADHLYYGGRRGSRQASLSPAGDSAVLVLPPPPSPGARSSSSRLSVVSEGESHLLREDSEVFKMLQENREARMAPRQSSSFRLLQEALEAEERGGTPAYLPSSLSPQSSLPTSRALASPPKLHTCEKCNTSIANQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQRYSAPPTLNSQA", "length": 348, "header": "sp|Q3T0C8-1|PDLI2_BOVIN Isoform 1 of PDZ and LIM domain protein 2 OS=Bos taurus OX=9913 GN=PDLIM2 PE=2 SV=1 CANONICAL=Q3T0C8-1" }, "locus": { "chromosome": "8", "start_pos": 69894952, "end_pos": 69883693, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009697.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009697.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009697.5", "url": "https://www.ensembl.org/id/ENSBTAP00000009697.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 117, "end_pos": 117, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "site_lbl": "Ser117" }, { "start_pos": 119, "end_pos": 119, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "site_lbl": "Ser119" }, { "start_pos": 124, "end_pos": 124, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "site_lbl": "Ser124" }, { "start_pos": 128, "end_pos": 128, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "site_lbl": "Thr128" }, { "start_pos": 132, "end_pos": 132, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "site_lbl": "Thr132" }, { "start_pos": 133, "end_pos": 133, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "site_lbl": "Ser133" }, { "start_pos": 153, "end_pos": 153, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "site_lbl": "Ser153" }, { "start_pos": 191, "end_pos": 191, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "site_lbl": "Ser191" }, { "start_pos": 197, "end_pos": 197, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "site_lbl": "Ser197" }, { "start_pos": 198, "end_pos": 198, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "site_lbl": "Ser198" }, { "start_pos": 202, "end_pos": 202, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "site_lbl": "Ser202" }, { "start_pos": 209, "end_pos": 209, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "site_lbl": "Ser209" }, { "start_pos": 262, "end_pos": 262, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "site_lbl": "Ser262" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512907", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512907", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7GS67-1", "protein_name": "PDZ and LIM domain protein 2", "gene_name": "Pdlim2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPLTVDVVGPAPWGFRISGGRDFHTPIIVTKVTERGKAEAADLRPGDIIVAINGERAESMLHAEAQSKIRQSASPLRLQLDRSQPASPGQTNGDGSLEVLAARFQGSLRTHHDSQFSKRPAYFSQASLSPRPGSPFSTPPPTSPLAVSGEDVIGCSFQSLTHSPGPAATHHLSYPGHPTSQQASHSSTSNFTVRVPLHSPGPRSSSPRFSGLDLEEDSEVFKMLQENRQGRAAPRQSSSFRLLQEALEAEERGGTPAFVPSSLSSQASLPTSKALATPPKLHTCEKCSANISNQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGNELYCEKHARQRYSMPGTLSSRA", "length": 350 }, "evidence": [ { "id": "Q3T0C8", "url": "https://omabrowser.org/oma/group/Q3T0C8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8D1S2M8-1", "protein_name": "PDZ and LIM domain protein 2", "gene_name": "PDLIM2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALTVDVVGPAPWGFRISGGRDFHMPITVTKVTERGKAEAADLRPGDIIVAINGESAKGMLHAEAQSKIRQSPSPLRLQLDRSRAASPGQTNGESSMEVLATRFQGSRRGHTDSQSSLRSSCSSQASLSPRPSSPFSTLPPTSPHTPAGEVVTSHSLQSLAHSPGPATADHLSYGGRPGSRQAGDWAVLVLPPQPSPGPRSSSPRLSVASEGESHLLREDSEVFKMLQENREARVAPRQSSSFRLLQEALEAEERGGTPAFLPSPLSPQSSLPTSRVLATPPKLHTCEKCSTSIANQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQRYSAPSTLNSQA", "length": 353 }, "evidence": [ { "id": "Q3T0C8", "url": "https://omabrowser.org/oma/group/Q3T0C8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M3AVD9-1", "protein_name": "PDZ and LIM domain protein 2", "gene_name": "pdlim2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMPFTVNLIGPSPWGFRISGGRDFKKAITVSKVNAGSKAETACLQPGDIIMEINGLSAGEMLNVEAQNKIKCCTTQLQLLVERPAPPTPGQTNGITEQLVGRFQEAVQVSRDENQNYKEYTISSPASLSPGPYTPEPPSSPDRRGGRITPTNKSLQFHSWSSEEKNVQSHRLSRPLSQEFSSLDFRSNCVSSRTPTPPGQYSPHSPIERELSVSPRRSSDFAMQKFDRDSEVYKMIQENKESRAAPRQSNTFKMLQEVLEADEKEAALRFPSKLSPNPPKTSSVAGVQKHHTCEKCGTSIVTQAVKITDNCYRHPECYTCTECGLNLKMRGHFWAEDKMFCEKHARERYQGPGSSPHSVVSPHH", "length": 364 }, "evidence": [ { "id": "Q3T0C8", "url": "https://omabrowser.org/oma/group/Q3T0C8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6AYD6-1", "protein_name": "PDZ and LIM domain protein 2", "gene_name": "Pdlim2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALTVNVVGPAPWGFRISGGRDFHTPIIVTKVTERGKAEAADLRPGDIIVAINGESAESMLHAEAQSKIRQSASPLRLQLDRSQTASPGQINGEGSLDMLATRFQGSLRTHHNSQSSQRSACFSPASLSPRPDSPFSTPPPTSPIALSGENVIGCSFQSLTHSPGLAATHHLTYPGQPTSQQAGHSSPSDSTVRVLLHSPGRPSSPRLSSLDLEEDSEVFKMLQENRQGRAAPRQSSSFRLLQEALEAEERGGTPAFVPSSLSPKASLPTSRALATPPKLHTCEKCSVNISNQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGNELYCEKHARQRYSMPGTLSSQA", "length": 349 }, "evidence": [ { "id": "Q3T0C8", "url": "https://omabrowser.org/oma/group/Q3T0C8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R1G6-1", "protein_name": "PDZ and LIM domain protein 2", "gene_name": "Pdlim2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALTVDVAGPAPWGFRISGGRDFHTPIIVTKVTERGKAEAADLRPGDIIVAINGQSAENMLHAEAQSKIRQSASPLRLQLDRSQTASPGQTNGEGSLEVLATRFQGSLRTHRDSQSSQRSACFSPVSLSPRPCSPFSTPPPTSPVALSKEDMIGCSFQSLTHSPGLAAAHHLTYPGHPTSQQAGHSSPSDSAVRVLLHSPGRPSSPRFSSLDLEEDSEVFKMLQENRQGRAAPRQSSSFRLLQEALEAEERGGTPAFVPSSLSSQASLPTSRALATPPKLHTCEKCSVNISNQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGNELYCEKHARQRYSMPGTLNSRA", "length": 349 }, "evidence": [ { "id": "Q3T0C8", "url": "https://omabrowser.org/oma/group/Q3T0C8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96JY6-1", "protein_name": "PDZ and LIM domain protein 2", "gene_name": "PDLIM2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALTVDVAGPAPWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHAEAQSKIRQSPSPLRLQLDRSQATSPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRSSYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRPGSRQAGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQSSSFRLLQEALEAEERGGTPAFLPSSLSPQSSLPASRALATPPKLHTCEKCSTSIANQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQRYSAPATLSSRA", "length": 352 }, "evidence": [ { "id": "Q3T0C8", "url": "https://omabrowser.org/oma/group/Q3T0C8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "muscle alpha-actinin binding", "id": "GO:0051371", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051371", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "pmid": "" }, { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "pmid": "" }, { "name": "stress fiber", "id": "GO:0001725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001725", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "pmid": "" }, { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "pmid": "" }, { "name": "filamentous actin", "id": "GO:0031941", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031941", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "pmid": "" }, { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "pmid": "" }, { "name": "protein catabolic process", "id": "GO:0030163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030163", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "pmid": "" }, { "name": "muscle structure development", "id": "GO:0061061", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061061", "evidence": [ { "database": "UniProtKB", "id": "Q3T0C8", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 286, "end_pos": 288, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0C8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 348, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0C8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0C8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3T0C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" }, { "id": "PRU00125", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00125" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LIM zinc-binding", "eco_id": "ECO_0000255", "start_pos": 280, "end_pos": 340, "start_aa": "His", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3T0C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0C8" }, { "id": "PRU00143", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00143" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000255", "start_pos": 1, "end_pos": 84, "start_aa": "Met", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 117, 119, 124, 128, 132, 133, 153, 191, 197, 198, 202, 209, 262 ], "sequon_annotation_sites": [ { "start_pos": 286, "end_pos": 288 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDE7-1", "uniprot_ac": "Q2YDE7", "uniprot_id": "ARCH_BOVIN", "mass": { "chemical_mass": 19432.0, "monoisotopic_mass": 19432.0 }, "refseq": { "ac": "NP_001069756", "name": "tRNA-splicing ligase-activating factor archease", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069756" }, "gene_names": [ { "name": "ZBTB8OS", "type": "recommended", "evidence": [ { "id": "Q2YDE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDE7" } ] }, { "name": "ZBTB8OS", "type": "synonym", "evidence": [ { "id": "NP_001069756", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069756" } ] } ], "protein_names": [ { "name": "tRNA-splicing ligase-activating factor archease", "type": "recommended", "evidence": [ { "id": "Q2YDE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDE7/entry#names_and_taxonomy" } ] }, { "name": "2.7.7.-", "type": "synonym", "evidence": [ { "id": "Q2YDE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDE7/entry#names_and_taxonomy" } ] }, { "name": "protein archease", "type": "synonym", "evidence": [ { "id": "NP_001069756", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069756" } ] }, { "name": "tRNA-splicing ligase-activating factor archease", "type": "synonym", "evidence": [ { "id": "NP_001069756", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069756" } ] } ], "function": [ { "annotation": "Activation factor of RTCB, the catalytic subunit of the tRNA-splicing ligase complex (tRNA-LC), which is involved in the enzyme-dependent maturation of intron-containing pre-tRNAs. Functions downstream of the tRNA-splicing endonuclease that removes introns, ligating the two generated halves via phosphodiester bond formation. Catalyzes the GTP-dependent activation of RTCB, both proteins forming a composite active site coordinating GTP and metal ions to enable the guanylylation of RTCB a prerequisite to undergo multiple catalytic cycles. Also required for the activation of RTCB in non-canonical, spliceosome-independent, cytoplasmic splicing of XBP1 mRNAs during the unfolded protein response (UPR). Upon endoplasmic reticulum (ER) stress, the endoribonuclease IRE1/ERN1 excises a short intron, generating free exon ends that are aligned by RNA-intrinsic, zipper-like stem-loop structures. These exon ends are then recognized and ligated by RTCB. This splicing event yields the active XBP1s transcription factor, which induces genes required to resolve protein folding defects in the endoplasmic reticulum.", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE7", "url": "https://www.uniprot.org/uniprotkb/Q2YDE7#function" }, { "database": "UniProtKB", "id": "Q8IWT0", "url": "https://www.uniprot.org/uniprotkb/Q8IWT0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDE7", "url": "https://www.uniprot.org/uniprotkb/Q2YDE7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZBTB8OS", "url": "https://www.uniprot.org/uniprotkb/Q2YDE7", "locus": { "chromosome": "2", "start_pos": 120999938, "end_pos": 120986576, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027159", "url": "https://www.ensembl.org/id/ENSBTAG00000027159" } ] } } ], "crossref": [ { "id": "Q2YDE7", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDE7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027159", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027159", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613795", "url": "https://www.ncbi.nlm.nih.gov/gene/613795", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002804", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002804", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023572", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023572", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036820", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036820", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613795", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613795", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AITYHKM", "url": "https://omabrowser.org/oma/group/AITYHKM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2YDE7", "url": "https://www.orthodb.org/?gene=Q2YDE7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12682", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12682", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12682:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12682:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01951", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01951", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069756", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "68084", "url": "https://www.rhea-db.org/rhea/68084", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TM33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TM33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM33-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZD96", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZD96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZD96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZD96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P063", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P063", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P063-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P063-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDE7", "url": 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"tr|A0AAA9TM33-1|ARCH_BOVIN Computationally mapped isoform of tRNA-splicing ligase-activating factor archease OS=Bos taurus OX=9913 GN=ZBTB8OS PE=2 SV=1 CANONICAL=Q2YDE7-1" }, "locus": { "chromosome": "2", "start_pos": 120998934, "end_pos": 120987011, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130120.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130120.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099445.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099445.1" } ] } }, { "isoform_ac": "A0AAF6ZD96-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDE7/entry#A0AAF6ZD96-1", "sequence": { "sequence": "MFSGLVGHARGKLARKAFITPRDLDHTADVQLHAWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTIEVETQGDDLQSLLFHFLDEWLYKFSADEFFIPREVKVLNIDQRNFKIRSIGWGEEFSLSKHPQGTEVKAITYSAMQVYNEEKPEVFVIIDI", "length": 157, "header": "tr|A0AAF6ZD96-1|ARCH_BOVIN Computationally mapped isoform of tRNA-splicing ligase-activating factor archease OS=Bos taurus OX=9913 GN=ZBTB8OS PE=2 SV=2 CANONICAL=Q2YDE7-1" }, "locus": { "chromosome": "2", "start_pos": 120998934, "end_pos": 120986640, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038930.7", "url": "https://www.ensembl.org/id/ENSBTAT00000038930.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038736.6", "url": "https://www.ensembl.org/id/ENSBTAP00000038736.6" } ] } }, { "isoform_ac": "A0ABI0P063-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDE7/entry#A0ABI0P063-1", "sequence": { "sequence": "MALEGEDVRDYNLTEEQKAIKAKYPPVSRKYECELHAWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTIEVETQGDDLQSLLFHFLDEWLYKFSADEFFIPREVKVLNIDQRNFKIRSIGWGEEFSLSKHPQGTEVKAITYSAMQVYNEEKPEVFVIIDI", "length": 160, "header": "tr|A0ABI0P063-1|A0ABI0P063_BOVIN Computationally mapped isoform of tRNA-splicing ligase-activating factor archease OS=Bos taurus OX=9913 GN=ZBTB8OS PE=3 SV=1 CANONICAL=Q2YDE7-1" }, "locus": { "chromosome": "2", "start_pos": 120998934, "end_pos": 120987011, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000139855.1", "url": "https://www.ensembl.org/id/ENSBTAT00000139855.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107468.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107468.1" } ] } }, { "isoform_ac": "Q2YDE7-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDE7/entry#Q2YDE7-1", "sequence": { "sequence": "MALEGEDVRDYNLTEEQKAIKAKYPPVSRKYEYLDHTADVQLHAWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTIEVETQGDDLQSLLFHFLDEWLYKFSADEFFIPREVKVLNIDQRNFKIRSIGWGEEFSLSKHPQGTEVKAITYSAMQVYNEEKPEVFVIIDI", "length": 167, "header": "sp|Q2YDE7-1|ARCH_BOVIN Isoform 1 of tRNA-splicing ligase-activating factor archease OS=Bos taurus OX=9913 GN=ZBTB8OS PE=2 SV=2 CANONICAL=Q2YDE7-1" }, "locus": { "chromosome": "2", "start_pos": 120998934, "end_pos": 120987011, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133992.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133992.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092829.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092829.1" } ] } }, { "isoform_ac": "Q2YDE7-2", "url": "https://www.uniprot.org/uniprotkb/Q2YDE7/entry#Q2YDE7-2", "sequence": { "sequence": "MALEGEDVRDYNLTEEQKAIKAKYPPVSRKYEYLDHTADVQLHAWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTIEVETQGDDLQSLLFHFLDEWLYKFSADEFFIPREVKVLNIDQRNFKIRSIGWGEEFSLSKHPQMPAAAAAASRFSRVRLCVTPYTAAHQAPPSLGFSRELKSKQ", "length": 180, "header": "sp|Q2YDE7-2|ARCH_BOVIN Isoform 2 of tRNA-splicing ligase-activating factor archease OS=Bos taurus OX=9913 GN=ZBTB8OS PE=2 SV=2 CANONICAL=Q2YDE7-1" }, "locus": { "chromosome": "2", "start_pos": 120998869, "end_pos": 120987011, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038929.6", "url": "https://www.ensembl.org/id/ENSBTAT00000038929.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038735.3", "url": "https://www.ensembl.org/id/ENSBTAP00000038735.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], 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"database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9VD92-1", "protein_name": "Protein archease-like", "gene_name": "Archease", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEVEFSRENFLLPEMKYEYLDHTADVQIHGWGSSLKEAFEQCGVAMFGYMTELDYVSVEQCFEIEAHGDDLESLLFHFLDELLFLFSAEPYLVCKKLEITKFDVENFEISCHCYGEPFELGKHPQGTEVKAITYSAMQIIQDVEASNYEVFVIIDI", "length": 156 }, "evidence": [ { "id": "Q2YDE7", "url": "https://omabrowser.org/oma/group/Q2YDE7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "mRNA splicing, via endonucleolytic cleavage and ligation", "id": "GO:0070054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070054", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE7", "url": "https://www.uniprot.org/uniprotkb/Q2YDE7" } ], "pmid": "" }, { "name": "IRE1-mediated 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Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE7", "url": "https://www.uniprot.org/uniprotkb/Q2YDE7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE7", "url": "https://www.uniprot.org/uniprotkb/Q2YDE7" } ], "pmid": "" }, { "name": "tRNA-splicing ligase complex", "id": "GO:0072669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072669", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE7", "url": "https://www.uniprot.org/uniprotkb/Q2YDE7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE7", "url": 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"https://www.ensembl.org/id/ENSBTAG00000010787" } ] } } ], "crossref": [ { "id": "Q2TBV1", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBV1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010787", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010787", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00009", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00009", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515602", "url": "https://www.ncbi.nlm.nih.gov/gene/515602", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008921", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008921", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050238", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050238", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515602", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515602", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LKADIMH", "url": "https://omabrowser.org/oma/group/LKADIMH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBV1", "url": "https://www.orthodb.org/?gene=Q2TBV1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11669", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11669", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11669:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11669:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13177", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13177", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21960", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21960", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22534", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22534", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-110312", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110312", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-110314", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110314", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-110320", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110320", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174411", "url": 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}, { "id": "R-BTA-6782210", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6782210", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804756", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-69091", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69091", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-69473", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69473", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001033636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033636", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TML2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TML2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TML2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TML2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBV1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBV1-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLWVDKYRPCSLGQLDYHKEQAAQLRNLVQCGDFPHLLVYGPSGAGKKTRIMCILRELYGVGVEKLRIEHQTITTPSKKKIEISTIASNYHLEVNPSDAGNSDRVVIQEMLKTVAQSQQLETSSQKDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNLPPQLAHRLAEKSCRNLRKALLMCEACRVQQYPFTADQEIPETDWEVYLRETANAIVSQQTPQRLLEVRGRLYELLTHCIPPEIIMKGLLSELLHNCDGQLKGEVAQMAAYYEHRLQLGSKAIYHLEAFVAKFMALYKKFMEDGLEGMIF", "length": 356, "header": "sp|Q2TBV1-1|RFC3_BOVIN Isoform 1 of Replication factor C subunit 3 OS=Bos taurus OX=9913 GN=RFC3 PE=2 SV=1 CANONICAL=Q2TBV1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TML2-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV1/entry#A0AAA9TML2-1", "sequence": { "sequence": 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"https://www.uniprot.org/uniprotkb/Q2TBV1/entry#Q2TBV1-1", "sequence": { "sequence": "MSLWVDKYRPCSLGQLDYHKEQAAQLRNLVQCGDFPHLLVYGPSGAGKKTRIMCILRELYGVGVEKLRIEHQTITTPSKKKIEISTIASNYHLEVNPSDAGNSDRVVIQEMLKTVAQSQQLETSSQKDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNLPPQLAHRLAEKSCRNLRKALLMCEACRVQQYPFTADQEIPETDWEVYLRETANAIVSQQTPQRLLEVRGRLYELLTHCIPPEIIMKGLLSELLHNCDGQLKGEVAQMAAYYEHRLQLGSKAIYHLEAFVAKFMALYKKFMEDGLEGMIF", "length": 356, "header": "sp|Q2TBV1-1|RFC3_BOVIN Isoform 1 of Replication factor C subunit 3 OS=Bos taurus OX=9913 GN=RFC3 PE=2 SV=1 CANONICAL=Q2TBV1-1" }, "locus": { "chromosome": "12", "start_pos": 27396106, "end_pos": 27379016, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014278.5", "url": "https://www.ensembl.org/id/ENSBTAT00000014278.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014278.3", "url": "https://www.ensembl.org/id/ENSBTAP00000014278.3" } ] } } ], "glycosylation": [], 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"R-BTA-5656169", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5656169", "resource": "Reactome", "description": "Termination of translesion DNA synthesis" }, { "id": "R-BTA-5685938", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5685938", "resource": "Reactome", "description": "HDR through Single Strand Annealing (SSA)" }, { "id": "R-BTA-5685942", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5685942", "resource": "Reactome", "description": "HDR through Homologous Recombination (HRR)" }, { "id": "R-BTA-5693537", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693537", "resource": "Reactome", "description": "Resolution of D-Loop Structures" }, { "id": "R-BTA-5693607", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693607", "resource": "Reactome", "description": "Processing of DNA double-strand break ends" }, { "id": "R-BTA-5696397", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696397", "resource": "Reactome", "description": "Gap-filling DNA repair synthesis and ligation in GG-NER" }, { "id": "R-BTA-5696400", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696400", "resource": "Reactome", "description": "Dual Incision in GG-NER" }, { "id": "R-BTA-6782135", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6782135", "resource": "Reactome", "description": "Dual incision in TC-NER" }, { "id": "R-BTA-6782210", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6782210", "resource": "Reactome", "description": "Gap-filling DNA repair synthesis and ligation in TC-NER" }, { "id": "R-BTA-6804756", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804756", "resource": "Reactome", "description": "Regulation of TP53 Activity through Phosphorylation" }, { "id": "R-BTA-69091", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69091", "resource": "Reactome", "description": "Polymerase switching" }, { "id": "R-BTA-69473", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69473", "resource": "Reactome", "description": "G2/M DNA damage checkpoint" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480UUW0-1", "protein_name": "Replication factor C subunit 3", "gene_name": "RFC3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLWVDKYRPCSLGQLDYHKEQAAQLRNLVQCGDFPHLLVYGPSGAGKKTRIMCILRELYGVGVEKLRIEHQTITTPSKKKIEISTIASNYHLEVNPSDAGNSDRVVIQEMLKTVAQSQQLETNSQKDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLSLPSQLARKLAEKSCRNLRKALLMCEACRVQQYPFTVDQEIPETDWEVYLRETANAIVSQQTPQRLLEVRGRLYELLTHCIPPEIIMKGLLSELLHNCDGQLKGEVAQMAAYYEHRLQLGSKAIYHLEAFVAKFMALYKKFMEDGLEGMIF", "length": 356 }, "evidence": [ { "id": "Q2TBV1", "url": "https://omabrowser.org/oma/group/Q2TBV1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1P3C0-1", "protein_name": "Replication factor C subunit 3", "gene_name": "RFC3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSLWVDKYRPSALSRLDFHREQAAQLRSLVQCGDFPHLLVYGPSGAGKKTRIMCLLRELYGAGVEKLRIEHQSITAPSKKKIEISTIASNYHLEVNPSDAGNNDRVVIQELLKTVAQSQQLETSTQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMATCRLILCCNSISKIIGPIQSRCLSVRVPAPSIEDICHVLSSVCKKEGLNLPPELAQRLAEKSGRNLRKALLMCESCRVQQYPFSADQDIPEMDWEIYLRETANAIVSQQSPQRLLEVRGRLYELLTHCIPPEIIMKGLLTELLNNCDGQLKGEVAQMAAFYEHRLQLGSKAIYHLEAFVAKFMAIYKKFMEDGLDDMMF", "length": 356 }, "evidence": [ { "id": "Q2TBV1", "url": "https://omabrowser.org/oma/group/Q2TBV1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P38251-1", "protein_name": "Replication factor C subunit 5", "gene_name": "RFC5", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSLWVDKYRPKSLNALSHNEELTNFLKSLSDQPRDLPHLLLYGPNGTGKKTRCMALLESIFGPGVYRLKIDVRQFVTASNRKLELNVVSSPYHLEITPSDMGNNDRIVIQELLKEVAQMEQVDFQDSKDGLAHRYKCVIINEANSLTKDAQAALRRTMEKYSKNIRLIMVCDSMSPIIAPIKSRCLLIRCPAPSDSEISTILSDVVTNERIQLETKDILKRIAQASNGNLRVSLLMLESMALNNELALKSSSPIIKPDWIIVIHKLTRKIVKERSVNSLIECRAVLYDLLAHCIPANIILKELTFSLLDVETLNTTNKSSIIEYSSVFDERLSLGNKAIFHLEGFIAKVMCCLD", "length": 354 }, "evidence": [ { "id": "Q2TBV1", "url": "https://omabrowser.org/oma/group/Q2TBV1/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P40938-1", "protein_name": "Replication factor C subunit 3", "gene_name": "RFC3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLWVDKYRPCSLGRLDYHKEQAAQLRNLVQCGDFPHLLVYGPSGAGKKTRIMCILRELYGVGVEKLRIEHQTITTPSKKKIEISTIASNYHLEVNPSDAGNSDRVVIQEMLKTVAQSQQLETNSQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNLPSQLAHRLAEKSCRNLRKALLMCEACRVQQYPFTADQEIPETDWEVYLRETANAIVSQQTPQRLLEVRGRLYELLTHCIPPEIIMKGLLSELLHNCDGQLKGEVAQMAAYYEHRLQLGSKAIYHLEAFVAKFMALYKKFMEDGLEGMMF", "length": 356 }, "evidence": [ { "id": "Q2TBV1", "url": "https://omabrowser.org/oma/group/Q2TBV1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54BN3-1", "protein_name": "Probable replication factor C subunit 3", "gene_name": "rfc3", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLWIDKYKPTSLDKMDYHNDISINLKNMIKSGDFPHLLVYGPSGAGKKTRILAVLQEIYGPNALKLKIDHRTFKHPTSSKNIQITTISSHYHIEINPGEAGSYDRVVIQTIIKEIAQSPPIDSGSLGAFKIVILNEVDKLSKDAQHALRRTMEKYATFCRLILCCDSTAKVIDPIKSRCLGIRVPAPSQEEIEKVLAKVATAEKFDLPSKLAVNVAKQSGGNLRYALMLLESQKAKQYPFQSTELPLLDWENYISQIVKDCFEEQSPARLSIVRGKLYELLGHCIPPELIFKTLLLEIFKKLDHNMKFEIIHWASYYEHRSQIGSKPIFHLEAFIAKFMSVYKKYNQ", "length": 347 }, "evidence": [ { "id": "Q2TBV1", "url": "https://omabrowser.org/oma/group/Q2TBV1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5M830-1", "protein_name": "Replication factor C subunit 3", "gene_name": "Rfc3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLWVDKYRPSSLARLDYHKEQAAQLRNLVQCGDFPHLLVYGPSGAGKKTRIMCILRELYGVGVEKLRIEHQTITTPSKKKIEISTIASNYHLEVNPSDAGNSDRVVIQEMLKTVAQSQQLETSSQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVIPPIRSRCLAIRVPAPSIEDICSVLSTVCKKEGLALPSKLARRLAEKSCRNLRKALLMCEACRVQQYPFTEDQEIPETDWEVYLRETANAIVSQQTPQRLLEVRGRLYELLTHCIPPEVIMKGLLSELLHNCDGQLKGEVAQMAAYYEHRLQLGSKAIYHLEAFVAKFMALYKKFMEDGLEGMVF", "length": 356 }, "evidence": [ { "id": "Q2TBV1", "url": "https://omabrowser.org/oma/group/Q2TBV1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R323-1", "protein_name": "Replication factor C subunit 3", "gene_name": "Rfc3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLWVDKYRPSSLARLDYHKEQAAQLRNLVQCGDFPHLLVYGPSGAGKKTRIMCILRELYGIGVEKLRIEHQTITTPSKKKIEISTIASNYHLEVNPSDAGNSDRVVIQEMLKTVAQSQQLETSSQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVIPPIRSRCLAVRVPAPSIEDICSVLSTVCRKEGLALPSTLARRLAEKSCRNLRKALLMCEACRVQQYPFTEDQEIPETDWEVYLRETANAIVSQQTPQRLLEVRGRLYELLTHCIPPEIIMKGLLSELLHNCDGQLKGEVAQMAAYYEHRLQLGSKAIYHLEAFVAKFMALYKKFMEDGLEGMMF", "length": 356 }, "evidence": [ { "id": "Q2TBV1", "url": "https://omabrowser.org/oma/group/Q2TBV1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8VXX4-1", "protein_name": "Replication factor C subunit 3", "gene_name": "RFC3", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MLWVDKYRPKSLDKVIVHEDIAQKLKKLVSEQDCPHLLFYGPSGSGKKTLIMALLKQIYGASAEKVKVENRAWKVDAGSRTIDLELTTLSSTNHVELTPSDAGFQDRYIVQEIIKEMAKNRPIDTKGKKGYKVLVLNEVDKLSREAQHSLRRTMEKYSSSCRLILCCNSSSKVTEAIKSRCLNVRINAPSQEEIVKVLEFVAKKESLQLPQGFAARIAEKSNRSLRRAILSLETCRVQNYPFTGNQVISPMDWEEYVAEIATDMMKEQSPKKLFQVRGKVYELLVNCIPPEVILKRLLHELLKKLDSELKLEVCHWAAYYEHRMRLGQKAIFHIEAFVAKFMSIYKNFLISTFG", "length": 354 }, "evidence": [ { "id": "Q2TBV1", "url": "https://omabrowser.org/oma/group/Q2TBV1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9U9Q1-1", "protein_name": "Replication factor C subunit 3", "gene_name": "RfC38", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MALWVDKYRPRELSKLDFHKDQAENLRNLCKQSDFPHLMFYGPSGAGKKTRIMCLLREMYGSGVERLRSETMTFTTPSNRKVEVMTVSSNYHLEVNPSDAGMYDRTVVIDLIKQVAQTHQIEISGQREFKVIVISEGDELTKDAQHALRRTMEKYVATCRIIISVNSTSRIIPAIRSRCLGIRVAAPNETEIVSILQNTCKREGLALPVELAKRVVDKSERNLRRALLMLEAAKVAKAPFTANQEIPDLDWQVFLRETASQIISEQTPAKLEKIRERLYELLTQGVPPNLIFRGLVEQLVNNCDMSIKAKTLEFATEYEHRMQSGAKHIFHLEAFVAQFMNIYKKFLSELDMTDDF", "length": 356 }, "evidence": [ { "id": "Q2TBV1", "url": "https://omabrowser.org/oma/group/Q2TBV1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA strand elongation involved in DNA replication", "id": "GO:0006271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006271", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV1" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV1" } ], "pmid": "" }, { "name": "positive regulation of DNA-directed DNA polymerase activity", "id": "GO:1900264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900264", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV1" } ], "pmid": "" }, { "name": "DNA-templated DNA replication", "id": "GO:0006261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006261", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV1" } ], "pmid": "" }, { "name": "ATP-dependent activity, acting on DNA", "id": "GO:0008094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008094", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV1" } ], "pmid": "" }, { "name": "DNA clamp loader activity", "id": "GO:0003689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003689", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV1" } ], "pmid": "" }, { "name": "single-stranded DNA helicase activity", "id": "GO:0017116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017116", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV1" } ], "pmid": "" }, { "name": "Ctf18 RFC-like complex", "id": "GO:0031390", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031390", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV1" } ], "pmid": "" }, { "name": "DNA replication factor C complex", "id": "GO:0005663", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005663", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBV1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 356, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBV1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBV1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 125 ], "sequon_annotation_sites": [ { "start_pos": 166, "end_pos": 168 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L92-1", "uniprot_ac": "Q32L92", "uniprot_id": "CNN3_BOVIN", "mass": { "chemical_mass": 36358.0, "monoisotopic_mass": 36358.0 }, "refseq": { "ac": "NP_001033268", "name": "calponin-3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033268" }, "gene_names": [ { "name": "CNN3", "type": "recommended", "evidence": [ { "id": "Q32L92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L92" } ] }, { "name": "CNN3", "type": "synonym", "evidence": [ { "id": "NP_001033268", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033268" } ] } ], "protein_names": [ { "name": "Calponin-3", "type": "recommended", "evidence": [ { "id": "Q32L92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L92/entry#names_and_taxonomy" } ] }, { "name": "Calponin, acidic isoform", "type": "synonym", "evidence": [ { "id": "Q32L92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L92/entry#names_and_taxonomy" } ] }, { "name": "calponin 3, acidic", "type": "synonym", "evidence": [ { "id": "NP_001033268", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033268" } ] }, { "name": "calponin-3", "type": "synonym", "evidence": [ { "id": "NP_001033268", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033268" } ] } ], "function": [ { "annotation": "Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TNI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNI3#function" }, { "database": "UniProtKB", "id": "RU361224", "url": "https://www.uniprot.org/uniprotkb/RU361224#function" }, { "database": "UniProtKB", "id": "ARBA00025109", "url": "https://www.uniprot.org/uniprotkb/ARBA00025109#function" }, { "database": "UniProtKB", "id": "Q32L92", "url": "https://www.uniprot.org/uniprotkb/Q32L92#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L92", "url": "https://www.uniprot.org/uniprotkb/Q32L92" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CNN3", "url": "https://www.uniprot.org/uniprotkb/Q32L92", "locus": { "chromosome": "3", "start_pos": 48599126, "end_pos": 48568965, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020345", "url": "https://www.ensembl.org/id/ENSBTAG00000020345" } ] } } ], "crossref": [ { "id": "Q32L92", "url": "https://alphafold.ebi.ac.uk/entry/Q32L92", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020345", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020345", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21284", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21284", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538975", "url": "https://www.ncbi.nlm.nih.gov/gene/538975", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000557", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000557", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001997", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001997", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050606", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050606", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538975", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538975", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YHSEYQD", "url": "https://omabrowser.org/oma/group/YHSEYQD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32L92", "url": "https://www.orthodb.org/?gene=Q32L92", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47385", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47385", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47385:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47385:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00402", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00402", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033268", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TNI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNI3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L92", "url": "https://www.uniprot.org/uniprotkb/Q32L92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L92-1", "url": "https://www.uniprot.org/uniprotkb/Q32L92-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTHFNKGPSYGLSAEVKNKIASKYDHQAEEDLRNWIEEVTGMSIGANFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGLAKTKGFHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAGMLAPGTRRDIYDQKLTLQPVDNSTISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAPTEPVIHNGSQGTGTNGSEISDSDYQAEYPDEYHGEYQDDYPRDYQYGDQGIDY", "length": 329, "header": "sp|Q32L92-1|CNN3_BOVIN Isoform 1 of Calponin-3 OS=Bos taurus OX=9913 GN=CNN3 PE=2 SV=1 CANONICAL=Q32L92-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TNI3-1", "url": "https://www.uniprot.org/uniprotkb/Q32L92/entry#A0AAA9TNI3-1", "sequence": { "sequence": "MTHFNKGPSYGLSAEVKNKIASKYDHQAEEDLRNWIEEVTGMSIGANFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQAKTKGFHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAGMLAPGTRRDIYDQKLTLQPVDNSTISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAPTEPVIHNGSQGTGTNGSEISDSDYQAEYPDEYHGEYQDDYPRDYQYGDQGIDY", "length": 283, "header": "tr|A0AAA9TNI3-1|CNN3_BOVIN Computationally mapped isoform of Calponin-3 OS=Bos taurus OX=9913 GN=CNN3 PE=2 SV=1 CANONICAL=Q32L92-1" }, "locus": { "chromosome": "3", "start_pos": 48598606, "end_pos": 48569197, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091895.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091895.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097902.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097902.1" } ] } }, { "isoform_ac": "Q32L92-1", "url": "https://www.uniprot.org/uniprotkb/Q32L92/entry#Q32L92-1", "sequence": { "sequence": "MTHFNKGPSYGLSAEVKNKIASKYDHQAEEDLRNWIEEVTGMSIGANFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGLAKTKGFHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAGMLAPGTRRDIYDQKLTLQPVDNSTISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAPTEPVIHNGSQGTGTNGSEISDSDYQAEYPDEYHGEYQDDYPRDYQYGDQGIDY", "length": 329, "header": "sp|Q32L92-1|CNN3_BOVIN Isoform 1 of Calponin-3 OS=Bos taurus OX=9913 GN=CNN3 PE=2 SV=1 CANONICAL=Q32L92-1" }, "locus": { "chromosome": "3", "start_pos": 48598606, "end_pos": 48569197, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027115.5", "url": "https://www.ensembl.org/id/ENSBTAT00000027115.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027115.3", "url": "https://www.ensembl.org/id/ENSBTAP00000027115.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538975", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538975", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1L1RWF6-1", "protein_name": "Calponin", "gene_name": "CNN3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTHFNKGPSYGLSAEVKNKIALKYDPQIEEDLRNWIEEVTGLSIGANFQLGLKDGIILCELINKLQPGSVKKINQSKLNWHQLENIGNFIKAIQVYGMKPHDIFEANDLFENGNMTQVQTTLVALAGLAKTKGFHTTIDIGVKYAEKQARSFDAGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAGMLAPGTRRDIYDQKHILQPVDNSTISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAPTEPVIHNGSQGTGTNGSEISDSDYQAEYPDDYHGEYQDDYQRDYHGQYSDQGIDY", "length": 331 }, "evidence": [ { "id": "Q32L92", "url": "https://omabrowser.org/oma/group/Q32L92/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P37397-1", "protein_name": "Calponin-3", "gene_name": "Cnn3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTHFNKGPSYGLSAEVKNKIASKYDQQAEEDLRNWIEEVTGMGIGTNFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGLAKTKGFHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAGMSAPGTRRDIYDQKLTLQPVDNSTISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAPTEPVIHNGSQGTGTNGSEISDSDYQAEYPDEYHGEYPDEYPREYQYGDDQGIDY", "length": 330 }, "evidence": [ { "id": "Q32L92", "url": "https://omabrowser.org/oma/group/Q32L92/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q15417-1", "protein_name": "Calponin-3", "gene_name": "CNN3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTHFNKGPSYGLSAEVKNKIASKYDHQAEEDLRNWIEEVTGMSIGPNFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGLAKTKGFHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAGMLAPGTRRDIYDQKLTLQPVDNSTISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAPTEPVIHNGSQGTGTNGSEISDSDYQAEYPDEYHGEYQDDYPRDYQYSDQGIDY", "length": 329 }, "evidence": [ { "id": "Q32L92", "url": "https://omabrowser.org/oma/group/Q32L92/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DAW9-1", "protein_name": "Calponin-3", "gene_name": "Cnn3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTHFNKGPSYGLSAEVKNKIASKYDQQAEEDLRNWIEEVTGLGIGTNFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGLAKTKGFHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAGMLAPGTRRDIYDQKLTLQPVDNSTISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAPTEPVIHNGSQGTGTNGSEISDSDYQAEYPDEYHGEYPDDYPREYQYGDDQGIDY", "length": 330 }, "evidence": [ { "id": "Q32L92", "url": "https://omabrowser.org/oma/group/Q32L92/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "Q32L92", "url": "https://www.uniprot.org/uniprotkb/Q32L92" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "Q32L92", "url": "https://www.uniprot.org/uniprotkb/Q32L92" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "Q32L92", "url": "https://www.uniprot.org/uniprotkb/Q32L92" } ], "pmid": "" }, { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "Q32L92", "url": "https://www.uniprot.org/uniprotkb/Q32L92" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "Q32L92", "url": "https://www.uniprot.org/uniprotkb/Q32L92" } ], "pmid": "" }, { "name": "actomyosin structure organization", "id": "GO:0031032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031032", "evidence": [ { "database": "UniProtKB", "id": "Q32L92", "url": "https://www.uniprot.org/uniprotkb/Q32L92" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "Q32L92", "url": "https://www.uniprot.org/uniprotkb/Q32L92" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" }, { "start_pos": 240, "end_pos": 242, "annotation": "n_glycosylation_sequon" }, { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" }, { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L92-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 329, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L92-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L92" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32L92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L92" }, { "id": "PRU00044", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00044" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000255", "start_pos": 26, "end_pos": 130, "start_aa": "His", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 114, "end_pos": 116 }, { "start_pos": 240, "end_pos": 242 }, { "start_pos": 283, "end_pos": 285 }, { "start_pos": 291, "end_pos": 293 }, { "start_pos": 74, "end_pos": 76 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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"total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TA17-1", "uniprot_ac": "Q2TA17", "uniprot_id": "ZN668_BOVIN", "mass": { "chemical_mass": 68095.0, "monoisotopic_mass": 68095.0 }, "refseq": { "ac": "NP_001070421", "name": "zinc finger protein 668", "summary": "", "url": 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May play a role in DNA repair process.", "evidence": [ { "database": "UniProtKB", "id": "Q2TA17", "url": "https://www.uniprot.org/uniprotkb/Q2TA17#function" }, { "database": "UniProtKB", "id": "Q96K58", "url": "https://www.uniprot.org/uniprotkb/Q96K58#function" }, { "database": "UniProtKB", "id": "A0AAA9TRN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRN0#function" }, { "database": "UniProtKB", "id": "ARBA00059778", "url": "https://www.uniprot.org/uniprotkb/ARBA00059778#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TA17", "url": "https://www.uniprot.org/uniprotkb/Q2TA17" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF668", "url": "https://www.uniprot.org/uniprotkb/Q2TA17", "locus": { "chromosome": "25", "start_pos": 27175346, "end_pos": 27184961, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006650", "url": "https://www.ensembl.org/id/ENSBTAG00000006650" } ] } } ], "crossref": [ { "id": "Q2TA17", "url": "https://alphafold.ebi.ac.uk/entry/Q2TA17", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006650", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006650", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767831", "url": "https://www.ncbi.nlm.nih.gov/gene/767831", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767831", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767831", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WDEVQAH", "url": "https://omabrowser.org/oma/group/WDEVQAH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TA17", "url": "https://www.orthodb.org/?gene=Q2TA17", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF152", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF152", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001070421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070421", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TRN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRN0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TA17", "url": "https://www.uniprot.org/uniprotkb/Q2TA17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TA17-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA17-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVESPEERSPAPGYKRSGRRYKCLSCTKTFPNAPRAARHAATHGLADCTEEMAEAKLKPETDPKAEDASGDKVSGAAAKPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCAHCPKAYGALSKLKIHQRGHTGERPYTCADCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSHTGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADLAMHRRVHTGDRPFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTKHSRVHSGERPFHCNACGKSFVVSSSLRKHERTHRSSEATGAPPQQELVVGLALPVSMAGEGPAAPASGAALGDPPAGLLGLPSESGGVMATQWQVVGMTVEHVECQDAGVGEAPGPLGAAGEVGGEEVDEKPPQFVCRECKETFSTLTLLRRHERSHPELRPFHCTQCGKSFSDRAGLRKHSRTHSSVRPYTCPHCPKAFLSASDLRKHERTHPVPIGTPTPLEPLVALLGMPEEGPA", "length": 619, "header": "sp|Q2TA17-1|ZN668_BOVIN Isoform 1 of Zinc finger protein 668 OS=Bos taurus OX=9913 GN=ZNF668 PE=2 SV=2 CANONICAL=Q2TA17-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TRN0-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA17/entry#A0AAA9TRN0-1", "sequence": { "sequence": "MLWNISGFREDPPIEAMEVESPEERSPAPGYKRSGRRYKCLSCTKTFPNAPRAARHAATHGLADCTEEMAEAKLKPETDPKAEDASGDKVSGAAAKPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCAHCPKAYGALSKLKIHQRGHTGERPYTCADCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSHTGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADLAMHRRVHTGDRPFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTKHSRVHSGERPFHCNACGKSFVVSSSLRKHERTHRSSEATGAPPQQELVVGLALPVSMAGEGPAAPASGAALGDPPAGLLGLPSESGGVMATQWQVVGMTVEHVECQDAGVGEAPGPLGAAGEVGGEEVDEKPPQFVCRECKETFSTLTLLRRHERSHPELRPFHCTQCGKSFSDRAGLRKHSRTHSSVRPYTCPHCPKAFLSASDLRKHERTHPVPIGTPTPLEPLVALLGMPEEGPA", "length": 635, "header": "tr|A0AAA9TRN0-1|ZN668_BOVIN Computationally mapped isoform of Zinc finger protein 668 OS=Bos taurus OX=9913 GN=ZNF668 PE=2 SV=1 CANONICAL=Q2TA17-1" }, "locus": { "chromosome": "25", "start_pos": 27184701, "end_pos": 27175818, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112441.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112441.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099975.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099975.1" } ] } }, { "isoform_ac": "Q2TA17-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA17/entry#Q2TA17-1", "sequence": { "sequence": "MEVESPEERSPAPGYKRSGRRYKCLSCTKTFPNAPRAARHAATHGLADCTEEMAEAKLKPETDPKAEDASGDKVSGAAAKPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCAHCPKAYGALSKLKIHQRGHTGERPYTCADCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSHTGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADLAMHRRVHTGDRPFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTKHSRVHSGERPFHCNACGKSFVVSSSLRKHERTHRSSEATGAPPQQELVVGLALPVSMAGEGPAAPASGAALGDPPAGLLGLPSESGGVMATQWQVVGMTVEHVECQDAGVGEAPGPLGAAGEVGGEEVDEKPPQFVCRECKETFSTLTLLRRHERSHPELRPFHCTQCGKSFSDRAGLRKHSRTHSSVRPYTCPHCPKAFLSASDLRKHERTHPVPIGTPTPLEPLVALLGMPEEGPA", "length": 619, "header": "sp|Q2TA17-1|ZN668_BOVIN Isoform 1 of Zinc finger protein 668 OS=Bos taurus OX=9913 GN=ZNF668 PE=2 SV=2 CANONICAL=Q2TA17-1" }, "locus": { "chromosome": "25", "start_pos": 27178115, "end_pos": 27175818, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008736.4", "url": "https://www.ensembl.org/id/ENSBTAT00000008736.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008736.3", "url": "https://www.ensembl.org/id/ENSBTAP00000008736.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 10, "end_pos": 10, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TA17", "url": "https://www.uniprot.org/uniprotkb/Q2TA17" } ], "site_lbl": "Ser10" }, { "start_pos": 387, "end_pos": 387, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TA17", "url": "https://www.uniprot.org/uniprotkb/Q2TA17" } ], "site_lbl": "Ser387" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q2TA17", "url": "https://www.uniprot.org/uniprotkb/Q2TA17" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:767831", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767831", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZPP0-1", "protein_name": "Zinc finger protein 668", "gene_name": "Zfp668", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEVEAAEAKSPGPCYKRSGRRYKCLFCTKTFPNAPRAARHAATHTTTDCTEEVNEVQPKVDAEPKAEEASGDKVSGSVAKPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCTHCPKAYGTLSKLKIHQRGHTGERPYACTDCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSHTGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADLAMHRRVHTGDRPFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTKHSRMHSGERPFHCNACGKSFVVLSSLRKHERTHRSNETTGAAPQQELVLGLALPVGVVGEGSAAPVAGAGIGDAPAGLLGLPPESGSVVATQWQVVGMTVEHVECQDAGVGEAPSTLGDAGEVGGEETDEKPPQFVCRECKETFSTLTLLRRHERSHPELRPFPCTQCGKSFSDRAGLRKHSRTHSSVRPYSCSQCPKAFLSASDLRKHERTHPVPIGTPIPLEPLVALLGMPEEGSA", "length": 619 }, "evidence": [ { "id": "Q2TA17", "url": "https://omabrowser.org/oma/group/Q2TA17/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RIR3-1", "protein_name": "Zinc finger protein 668", "gene_name": "ZNF668", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEVESLEDRSPAPGYKRSGRRYKCLSCTKTFPNAPRAARHAATHGPADCTEEAAEVKLKPETDPKAEDASGDKVSGAAAKPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCAHCPKAYGALSKLKIHQRGHTGERPYTCADCGKSFADPSVFRKHRRTHAGLRPYGCERCGKAYAELKDLRNHERSHTGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADLAMHRRVHTGDRPFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTKHSRVHSGERPFHCNACGKSFVVSSSLRKHERTHRSSEAAGAPPQQELVVGLALPVSVAGEGSAAPAAGAGLGDPPAGLLGLPPESGGVMATQWQVVGMTVEHVECQDAGVGEAPGPLGGAGEVGGEEVDEKPPQFVCRECKETFSTLTLLRRHERSHPELRPFPCTQCGKSFSDRAGLRKHSRTHSSVRPYTCPHCPKAFLSASDLRKHERTHPVPIGTPTPLEPLVALLGMPEEGPA", "length": 619 }, "evidence": [ { "id": "Q2TA17", "url": "https://omabrowser.org/oma/group/Q2TA17/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8K2R5-1", "protein_name": "Zinc finger protein 668", "gene_name": "Znf668", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEVEATEARSPGPCYKRSGRRYKCLFCTKTFPNAPRAARHAATHTPTDCTEEVREAQPKVDTEPKAEEASGDKVSASVAKPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCTHCPKAYGTLSKLKIHQRGHTGERPYACPDCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSHTGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYRCEKCGKDFRQPADLAMHRRVHTGDRPFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTKHSRMHSGERPFHCNACGKSFVVLSSLRKHERTHRSNETTGAAPQQELVLGLALPVGVVGEGSAAPVAGAGVGDAPAGLLGLPPESGGVVATQWQVVGMTVEHVECQDAGVGEAPSTLGDAGEVGGEETDEKPPQFVCRECKETFSTLTLLRRHERSHPELRPFPCTQCGKSFSDRAGLRKHSRTHSSVRPYSCSQCPKAFLSASDLRKHERTHPVPIGTPIPLEPLVALLGMPEEGSA", "length": 619 }, "evidence": [ { "id": "Q2TA17", "url": "https://omabrowser.org/oma/group/Q2TA17/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96K58-1", "protein_name": "Zinc finger protein 668", "gene_name": "ZNF668", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEVEAAEARSPAPGYKRSGRRYKCLSCTKTFPNAPRAARHAATHGPADCSEEVAEVKPKPETEAKAEEASGEKVSGSAAKPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCAHCPKAYGALSKLKIHQRGHTGERPYACADCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSHTGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYHCEKCGKDFRQPADLAMHRRVHTGDRPFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTKHSRVHSGERPFHCNACGKSFVVSSSLRKHERTHRSSEAAGVPPAQELVVGLALPVGVAGESSAAPAAGAGLGDPPAGLLGLPPESGGVMATQWQVVGMTVEHVECQDAGVREAPGPLEGAGEAGGEEADEKPPQFVCRECKETFSTMTLLRRHERSHPELRPFPCTQCGKSFSDRAGLRKHSRTHSSVRPYTCPHCPKAFLSASDLRKHERTHPVPMGTPTPLEPLVALLGMPEEGPA", "length": 619 }, "evidence": [ { "id": "Q2TA17", "url": "https://omabrowser.org/oma/group/Q2TA17/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TA17", "url": "https://www.uniprot.org/uniprotkb/Q2TA17" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "Q2TA17", "url": "https://www.uniprot.org/uniprotkb/Q2TA17" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q2TA17", "url": "https://www.uniprot.org/uniprotkb/Q2TA17" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q2TA17", "url": "https://www.uniprot.org/uniprotkb/Q2TA17" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q2TA17", "url": "https://www.uniprot.org/uniprotkb/Q2TA17" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "Q2TA17", "url": "https://www.uniprot.org/uniprotkb/Q2TA17" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "Q2TA17", "url": "https://www.uniprot.org/uniprotkb/Q2TA17" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q2TA17", "url": "https://www.uniprot.org/uniprotkb/Q2TA17" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TA17-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 619, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TA17-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TA17" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 10, 387 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3MHE8-1", "uniprot_ac": "Q3MHE8", "uniprot_id": "SRPRA_BOVIN", "mass": { "chemical_mass": 69896.0, "monoisotopic_mass": 69896.0 }, "refseq": { "ac": "NP_001068590", "name": "signal recognition particle receptor subunit alpha", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068590" }, "gene_names": [ { "name": "SRPRA", "type": "recommended", "evidence": [ { "id": "Q3MHE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8" } ] }, { "name": "SRPRA", "type": "synonym", "evidence": [ { "id": "NP_001068590", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068590" } ] }, { "name": "SRPR", "type": "synonym", "evidence": [ { "id": "NP_001068590", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068590" }, { "id": "Q3MHE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8" } ] } ], "protein_names": [ { "name": "Signal recognition particle receptor subunit alpha", "type": "recommended", "evidence": [ { "id": "Q3MHE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8/entry#names_and_taxonomy" } ] }, { "name": "DP-alpha", "type": "synonym", "evidence": [ { "id": "NP_001068590", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068590" }, { "id": "Q3MHE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8/entry#names_and_taxonomy" } ] }, { "name": "Docking protein alpha", "type": "synonym", "evidence": [ { "id": "Q3MHE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8/entry#names_and_taxonomy" } ] }, { "name": "SR-alpha", "type": "synonym", "evidence": [ { "id": "NP_001068590", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068590" }, { "id": "Q3MHE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8/entry#names_and_taxonomy" } ] }, { "name": "SRP receptor alpha subunit", "type": "synonym", "evidence": [ { "id": "NP_001068590", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068590" } ] }, { "name": "docking protein alpha", "type": "synonym", "evidence": [ { "id": "NP_001068590", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068590" } ] }, { "name": "signal recognition particle receptor ('docking protein')", "type": "synonym", "evidence": [ { "id": "NP_001068590", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068590" } ] }, { "name": "signal recognition particle receptor (docking protein)", "type": "synonym", "evidence": [ { "id": "NP_001068590", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068590" } ] }, { "name": "signal recognition particle receptor subunit alpha", "type": "synonym", "evidence": [ { "id": "NP_001068590", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068590" } ] } ], "function": [ { "annotation": "Component of the SRP (signal recognition particle) receptor (By similarity). Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (By similarity). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE8", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8#function" }, { "database": "UniProtKB", "id": "P08240", "url": "https://www.uniprot.org/uniprotkb/P08240#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHE8", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SRPRA", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8", "locus": { "chromosome": "29", "start_pos": 29610847, "end_pos": 29617171, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014105", "url": "https://www.ensembl.org/id/ENSBTAG00000014105" } ] } } ], "crossref": [ { "id": "Q3MHE8", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHE8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014105", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014105", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14826", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14826", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17876", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17876", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "281504", "url": "https://www.ncbi.nlm.nih.gov/gene/281504", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000897", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000897", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013822", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013822", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042101", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042101", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281504", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281504", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HLGWIDK", "url": "https://omabrowser.org/oma/group/HLGWIDK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3MHE8", "url": "https://www.orthodb.org/?gene=Q3MHE8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43134", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43134", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43134:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43134:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00448", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00448", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02881", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02881", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04086", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04086", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001068590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068590", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TS97", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS97-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS97-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHE8", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHE8-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLDFFTIFSKGGLVLWCFQGVSDSCTGPVNALIRSVLLQERGGNNSFTHEALTLKYKLDNQFELVFVVGFQKILTLTYVDKLIDDVHRLFRDKYRTEIQQQSALSLLNGTFDFQNDFLRLLREAEESSKIRAPTTMKKFEDSEKAKKPVRSMIETRGEKPKEKAKNNKKNKGAKKEGSDGPLATSKAAPAEKSGLPVGPENGEELSKEEQIRRKREEFIQKHGRGMEKSSKSSKSDAPKEKGKKAPRVWALGGSANKEVLDYSTPTTNGAPEAAPPEDINLIRGTGPGRQLQDLDCSSSDDEGAAQNSTKPSATKGTLGGMFGMLKGLVGSKSLTREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKVMGTFSTVTSTVKQALQESLVQILQPQRRVDMLRDIMDAQRHQRPYVVTFCGVNGVGKSTNLAKISFWLLENGFSVLIAACDTFRAGAVEQLRTHTRRLSALHPPEKHGGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGFDVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQTPRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAVVAALMKA", "length": 639, "header": "sp|Q3MHE8-1|SRPRA_BOVIN Isoform 1 of Signal recognition particle receptor subunit alpha OS=Bos taurus OX=9913 GN=SRPRA PE=2 SV=1 CANONICAL=Q3MHE8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TS97-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8/entry#A0AAA9TS97-1", "sequence": { "sequence": "MLDFFTIFSKGGLVLWCFQGVSDSCTGPVNALIRSVLLQVGFQKILTLTYVDKLIDDVHRLFRDKYRTEIQQQSALSLLNGTFDFQNDFLRLLREAEESSKIRAPTTMKKFEDSEKAKKPVRSMIETRGEKPKEKAKNNKKNKGAKKEGSDGPLATSKAAPAEKSGLPVGPENGEELSKEEQIRRKREEFIQKHGRGMEKSSKSSKSDAPKEKGKKAPRVWALGGSANKEVLDYSTPTTNGAPEAAPPEDINLIRGTGPGRQLQDLDCSSSDDEGAAQNSTKPSATKGTLGGMFGMLKGLVGSKSLTREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKVMGTFSTVTSTVKQALQESLVQILQPQRRVDMLRDIMDAQRHQRPYVVTFCGVNGVGKSTNLAKISFWLLENGFSVLIAACDTFRAGAVEQLRTHTRRLSALHPPEKHGGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGFDVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQTPRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAVVAALMKA", "length": 611, "header": "tr|A0AAA9TS97-1|SRPRA_BOVIN Computationally mapped isoform of Signal recognition particle receptor subunit alpha OS=Bos taurus OX=9913 GN=SRPRA PE=2 SV=1 CANONICAL=Q3MHE8-1" }, "locus": { "chromosome": "29", "start_pos": 29617115, "end_pos": 29611778, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121234.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121234.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099909.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099909.1" } ] } }, { "isoform_ac": "Q3MHE8-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8/entry#Q3MHE8-1", "sequence": { "sequence": "MLDFFTIFSKGGLVLWCFQGVSDSCTGPVNALIRSVLLQERGGNNSFTHEALTLKYKLDNQFELVFVVGFQKILTLTYVDKLIDDVHRLFRDKYRTEIQQQSALSLLNGTFDFQNDFLRLLREAEESSKIRAPTTMKKFEDSEKAKKPVRSMIETRGEKPKEKAKNNKKNKGAKKEGSDGPLATSKAAPAEKSGLPVGPENGEELSKEEQIRRKREEFIQKHGRGMEKSSKSSKSDAPKEKGKKAPRVWALGGSANKEVLDYSTPTTNGAPEAAPPEDINLIRGTGPGRQLQDLDCSSSDDEGAAQNSTKPSATKGTLGGMFGMLKGLVGSKSLTREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKVMGTFSTVTSTVKQALQESLVQILQPQRRVDMLRDIMDAQRHQRPYVVTFCGVNGVGKSTNLAKISFWLLENGFSVLIAACDTFRAGAVEQLRTHTRRLSALHPPEKHGGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGFDVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQTPRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAVVAALMKA", "length": 639, "header": "sp|Q3MHE8-1|SRPRA_BOVIN Isoform 1 of Signal recognition particle receptor subunit alpha OS=Bos taurus OX=9913 GN=SRPRA PE=2 SV=1 CANONICAL=Q3MHE8-1" }, "locus": { "chromosome": "29", "start_pos": 29617115, "end_pos": 29611778, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018762.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018762.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018762.6", "url": "https://www.ensembl.org/id/ENSBTAP00000018762.6" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 178, "end_pos": 178, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE8", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8" } ], "site_lbl": "Ser178" }, { "start_pos": 285, "end_pos": 285, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE8", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8" } ], "site_lbl": "Thr285" }, { "start_pos": 297, "end_pos": 297, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE8", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8" } ], "site_lbl": "Ser297" }, { "start_pos": 298, "end_pos": 298, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE8", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8" } ], "site_lbl": "Ser298" }, { "start_pos": 299, "end_pos": 299, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE8", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8" } ], "site_lbl": "Ser299" }, { "start_pos": 474, "end_pos": 474, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE8", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8" } ], "site_lbl": "Ser474" }, { "start_pos": 579, "end_pos": 579, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE8", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8" } ], "site_lbl": "Thr579" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:281504", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281504", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZUZ6-1", "protein_name": "SRP receptor alpha subunit", "gene_name": "SRPRA", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLDFFTIFSKGGLVLWCFQGVRGPASAATAPVNALIRSVLLQERGGNNSFTHEALTLKYKLDNQFELVFVVGFQKILTLTYVDKLIDDVHKEFRDKYRNEFQQKGALGILNGTFDFKDDFLRLLREAEESSKVRAPTVMKTFEQSVKSQKTVKCMIETRGEKPKEKVKNKKNKGSKKEGNEAVTASNKTAPGEKQSSAAGDKEELTKDEILQKNREEFFKRHMKAGEKSSKSPKPDAQKEKGKKPRVWDLGNSNAKVLDYSNSTTNGNSEASPMEDFDPDMALRDRNREPGRLYDLEYESDEEAEEEKIIQNASKPSTKKGGLGGMFGMLKGLVGSKSLTRQDMDPVLEKMKDHLIAKNVAAEIAVQLCESVAKKLEGKVMGTFTTVTSTVKQALQEALVQILQPQRRVDVLRDVMDAQRHRRPYVVTFCGVNGVGKSTNLAKISFWLIENGFSVLIAACDTFRAGAVEQLRTHTRRLNALHPPESHGGRTMVQLYEKGYGKDAAGIAMEAISYARNQGFDVVLVDTAGRMQDNAPLMTALAKLIAVNAPDLVLFVGEALVGNEAVDQLVKFNKALADHSMAQTPRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAVVAALMKA", "length": 644 }, "evidence": [ { "id": "Q3MHE8", "url": "https://omabrowser.org/oma/group/Q3MHE8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HFJ5-1", "protein_name": "Signal recognition particle receptor subunit alpha", "gene_name": "Srpra", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLDFFTIFSKGGLVLWCFQGVSDSCTGPVNALIRSVLLQERGGNNSFTHEALTLKYKLDNQFELVFVVGFQKILTLTYVDKLIDDVHRLFRDKYRTEIQQQSALSLLNGTFDFQNDFLRLLREAEESSKIRAPTTMKKFEDSEKSKKPVRSMIETRGEKTKEKTKNNKKKGAKKEGSDGPLATSKTAPAEKSGLPVGPENGELSKEELIRRKREEFIQKHGKGLDKSSKSTKSDTPKEKGKKAPRVWELGGCANKEVLDYSAPTTNGTPEAALSEDINLIRGTGPGGQLQDLDCSSSDDEGATQNTKPSATKGALGGMFGMLKGLVGSKSLSREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKVMGTFSTVTSTVKQALQESLVQILQPQRRVDMLRDIMDAQRRQRPYVVTFCGVNGVGKSTNLAKISFWLLENGFSVLIAACDTFRAGAVEQLRTHTRRLTALHPPEKHGGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGFDVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQTPRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAVVAALMKA", "length": 636 }, "evidence": [ { "id": "Q3MHE8", "url": "https://omabrowser.org/oma/group/Q3MHE8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P08240-1", "protein_name": "Signal recognition particle receptor subunit alpha", "gene_name": "SRPRA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLDFFTIFSKGGLVLWCFQGVSDSCTGPVNALIRSVLLQERGGNNSFTHEALTLKYKLDNQFELVFVVGFQKILTLTYVDKLIDDVHRLFRDKYRTEIQQQSALSLLNGTFDFQNDFLRLLREAEESSKIRAPTTMKKFEDSEKAKKPVRSMIETRGEKPKEKAKNSKKKGAKKEGSDGPLATSKPVPAEKSGLPVGPENGVELSKEELIRRKREEFIQKHGRGMEKSNKSTKSDAPKEKGKKAPRVWELGGCANKEVLDYSTPTTNGTPEAALSEDINLIRGTGSGGQLQDLDCSSSDDEGAAQNSTKPSATKGTLGGMFGMLKGLVGSKSLSREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKVMGTFSTVTSTVKQALQESLVQILQPQRRVDMLRDIMDAQRRQRPYVVTFCGVNGVGKSTNLAKISFWLLENGFSVLIAACDTFRAGAVEQLRTHTRRLSALHPPEKHGGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGFDVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQTPRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAVVAALMKA", "length": 638 }, "evidence": [ { "id": "Q3MHE8", "url": "https://omabrowser.org/oma/group/Q3MHE8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54ZR7-1", "protein_name": "Signal recognition particle receptor subunit alpha", "gene_name": "srpra", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLDSFTILTKGGIVLWSKEFAKIKGSPINSLIKKVLLEERSAETSFQIDSYSLKWTFSNEFDLIFVVVYQKIFTLLYIEELLTTVKKRFIKMYKDLLLKLKESSDFIIVDKFQEFNFEVILEDVENRSKLQQTSNSAPKKYEDTDKGKLVKDQKNERAIKEGRVEKVKRKEQEKKEKAERRKQNKANNINDISSDDDSDDSDSSSGSDSEENSNGATKNQQTDVARIENSGYKKKVKDTPDKQASSSTGKKARTWEDGKLSKKELEALNRSDNSNGTEIVREKIQKFNIDMDVSSSDDDDEEEAKPVSGFMKYFNVLTGNRVIDKQDLEPILADFKLHLTKKNVAPDVADKIVQSIGTGLEGKKLATFQGVTSVVKQQMEDTITRILTPKRNIDILREVQAVKGKRPYSIVFSGVNGVGKSTNLAKVCYWLTANGYKCMLAACDTFRSGAIEQLKTHADRLNVHLFERGYSKDAASVAQDAIAFAKDTGYDVVLIDTTGRMQNNEPLMKALSKLVNQNNVDLVLFVGEALVGNDGVDQLTKFDKSLSLLANTTQTHIRTIDGIILTKFDTIDDKVGAAISMVYSTGHPILFLGTGQNYTDLKRMNIKSVVKSLLH", "length": 615 }, "evidence": [ { "id": "Q3MHE8", "url": "https://omabrowser.org/oma/group/Q3MHE8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9DBG7-1", "protein_name": "Signal recognition particle receptor subunit alpha", "gene_name": "Srpra", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLDFFTIFSKGGLVLWCFQGVSDSCTGPVNALIRSVLLQERGGNNSFTHEALTLKYKLDNQFELVFVVGFQKILTLTYVDKLIDDVHRLFRDKYRTEIQQQSALSLLNGTFDFQNDFLRLLREAEESSKIRAPTTMKKFEDSEKAKKPVRSMIETRGEKTKEKAKNNKKRGAKKEGSDGTLATSKTAPAEKSGLSAGPENGELSKEELIRRKREEFIQKHGKGLDKSSKSTKSDTPKEKGKKAPRVWELGGCANKEVLDYSTPTTNGTPEAALSEDINLIRGTGPGGQLQDLDCSSSDDEGATQNTKPSATKGTLGGMFGMLKGLVGSKSLSREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKVMGTFSTVTSTVKQALQESLVQILQPQRRVDMLRDIMDAQRRQRPYVVTFCGVNGVGKSTNLAKISFWLLENGFSVLIAACDTFRAGAVEQLRTHTRRLTALHPPEKHGGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGFDVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQTPRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAVVAALMKA", "length": 636 }, "evidence": [ { "id": "Q3MHE8", "url": "https://omabrowser.org/oma/group/Q3MHE8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9M0A0-1", "protein_name": "Signal recognition particle receptor alpha subunit family protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MLEQLLIFTRGGLILWTCKEIGNALKGSPIDTLIRSCLLEERSGAVSFNYDAPGAAYTLKWTFHNDLGLVFVAVYQRILHLLYVDDLLSMVKQSFSEVYDPKRMAYDDFDETFRQLRIEAEARAEELRKTKQVGKPVTSVKKQGQVSKPGLEGGNKRVSSEGGSKKDDGDGGNKAKVSTLTNGHSNGNHQMEDDSQETNDLANGKENTSSNVAVDLSKLQKLRSKGVRGRGGVRKTDSIGNKSSKVAEPAKKATKKNRVWDDAAPKQSKLDFTDSIDENGNNDHVDIVAADQGESMMDKEEVFSSDSESEDDDEPGSDEKPAQAKKKGWFSSVFQSITGKANLERTDLGPALKALKERLMTKNVAEEIAEKLCESVEASLEGKKLSSFTRISSTVQAAMEDALVRILTPRRSIDILRDVHAAKEQRKPYVVVFVGVNGVGKSTNLAKVAYWLQQHKVSVMMAACDTFRSGAVEQLRTHARRLQIPIFEKGYEKDPAVVAKEAIQEATRNGSDVVLVDTAGRMQDNEPLMRALSKLINLNQPDLVLFVGEALVGNDAVDQLSKFNQKLSDLSTSGNPRLIDGILLTKFDTIDDKVGAALSMVYISGSPVMFVGCGQSYTDLKKLNVKAIVKTLLK", "length": 634 }, "evidence": [ { "id": "Q3MHE8", "url": "https://omabrowser.org/oma/group/Q3MHE8/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9U5L1-1", "protein_name": "Signal recognition particle receptor subunit alpha homolog", "gene_name": "SrpRalpha", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLDFVVIFTKGGVVLWHSNASGNSFASCINSLIRGVILEERNTEAKYYEEDHLAVQFKLDNELDLVYAAIFQKVIKLNYLDGFLADMQAAFKEKYGDIRLGDDYDFDREYRRVLSAAEEASAKQVKAPKTMRSYNESQKSKKTVASMIQDDKKPVEKRVNIQEAPPPSKSQPSSPPTGSPMDKIIMEKRRKLREKLTPTKKTSPSDSKSSKPEKAGKKPRVWDLGGNSKDAALLDRSRDSPDDVQYQNINSELVGTMQGVIRDLDVESEDEADNEDASSEGEAEEQVQSKKGKRGGLLSYFKGIVGAKTMSLADLQPALEKMRDHLISKNVASEIAAKLCDSVAASLDGKQMGTFDSIASQVKEALTESLVRILSPKRRIDIIRDALESKRNGRPYTIIFCGVNGVGKSTNLAKICFWLIENDFNVLIAACDTFRAGAVEQLRTHTRHLNALHPAAKHDGRNMVQLYEKGYGKDAAGIAMEAIKFAHDTRVDVVLVDTAGRMQDNEPLMRSLSKLIKVNNPDLVLFVGEALVGNEAVDQLVKFNQSLADYSSNENPHIIDGIVLTKFDTIDDKVGAAISMTYITGQPIVFVGTGQTYADLKAINVNAVVNSLMK", "length": 614 }, "evidence": [ { "id": "Q3MHE8", "url": "https://omabrowser.org/oma/group/Q3MHE8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "signal recognition particle receptor complex", "id": "GO:0005785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005785", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE8", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE8", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "signal recognition particle binding", "id": "GO:0005047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005047", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE8", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8" } ], "pmid": "" }, { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE8", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE8", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE8", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8" } ], "pmid": "" }, { "name": "SRP-dependent cotranslational protein targeting to membrane", "id": "GO:0006614", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006614", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE8", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8" } ], "pmid": "" }, { "name": "protein targeting to ER", "id": "GO:0045047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045047", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE8", "url": "https://www.uniprot.org/uniprotkb/Q3MHE8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHE8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 639, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHE8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHE8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 178, 285, 297, 298, 299, 474, 579 ], "sequon_annotation_sites": [ { "start_pos": 108, "end_pos": 110 }, { "start_pos": 307, "end_pos": 309 }, { "start_pos": 44, "end_pos": 46 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZJ5-1", "uniprot_ac": "Q3SZJ5", "uniprot_id": "GATA5_BOVIN", "mass": { "chemical_mass": 41603.0, "monoisotopic_mass": 41603.0 }, "refseq": { "ac": "NP_001029393", "name": "transcription factor GATA-5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029393" }, "gene_names": [ { "name": "GATA5", "type": "recommended", "evidence": [ { "id": "Q3SZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ] }, { "name": "GATA5", "type": "synonym", "evidence": [ { "id": "NP_001029393", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029393" } ] } ], "protein_names": [ { "name": "Transcription factor GATA-5", "type": "recommended", "evidence": [ { "id": "Q3SZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5/entry#names_and_taxonomy" } ] }, { "name": "GATA-binding factor 5", "type": "synonym", "evidence": [ { "id": "NP_001029393", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029393" }, { "id": "Q3SZJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5/entry#names_and_taxonomy" } ] }, { "name": "transcription factor GATA-5", "type": "synonym", "evidence": [ { "id": "NP_001029393", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029393" } ] } ], "function": [ { "annotation": "Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5#function" }, { "database": "UniProtKB", "id": "Q9BWX5", "url": "https://www.uniprot.org/uniprotkb/Q9BWX5#function" }, { "database": "UniProtKB", "id": "P97489", "url": "https://www.uniprot.org/uniprotkb/P97489#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GATA5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5", "locus": { "chromosome": "13", "start_pos": 54809121, "end_pos": 54799159, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047944", "url": "https://www.ensembl.org/id/ENSBTAG00000047944" } ] } } ], "crossref": [ { "id": "Q3SZJ5", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZJ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047944", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047944", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00202", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00202", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504784", "url": "https://www.ncbi.nlm.nih.gov/gene/504784", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000679", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000679", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008013", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008013", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016375", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016375", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039355", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039355", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504784", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504784", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FEPEDYA", "url": "https://omabrowser.org/oma/group/FEPEDYA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZJ5", "url": "https://www.orthodb.org/?gene=Q3SZJ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10071", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10071", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10071:SF289", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10071:SF289", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00320", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00320", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05349", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05349", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983231", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029393", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TTU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTU4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTU4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZJ5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYQSLALAPSPGQTAYADSGAFLHTPGAGSPVFVPPARVPSMLPYLPACEPGPQAPAITAHPGWAQAAAADSSAFGSGSPHAPAAPPPGTTAFPFAHSSPGPGGGTGTRDNGAFQGAMLAREQYPAALGRPVSSSYPTAYPAYMSAEVAPSWTSGPLDGSVLHSLQGLPAGLPGRRAPFAAELLEEFPGEGRECVNCGALSTPLWRRDGTGHYLCNACGLYHKMNGVNRPLVRPQKRLSSSRRAGLCCTNCHTTTTTLWRRNVDGEPVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKNIAKTKGSSGSSGHTTASPQASVPDPEVSAATLKPEPSLASPSCPGPSVTSQGSAQVDDPLAPSHLEFKFEPEDFALPSAALGQQAGLGGALRQEAWCALALA", "length": 403, "header": "sp|Q3SZJ5-1|GATA5_BOVIN Isoform 1 of Transcription factor GATA-5 OS=Bos taurus OX=9913 GN=GATA5 PE=2 SV=1 CANONICAL=Q3SZJ5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TTU4-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5/entry#A0AAA9TTU4-1", "sequence": { "sequence": "MYQSLALAPSPGQTAYADSGAFLHTPGAGSPVFVPPARVPSMLPYLPACEPGPQAPAITAHPGWAQAAAADSSAFGSGSPHAPAAPPPGTTAFPFAHSSPGPGGGTGTRDNGAFQGAMLAREQYPAALGRPVSSSYPTAYPAYMSAEVAPSWTSGPLDGSVLHSLQGLPAGLPGRRAPFAAELLEEFPGEGRECVNCGALSTPLWRRDGTGHYLCNACGLYHKMNGVNRPLVRPQKRLSSSRRAGLCCTNCHTTTTTLWRRNVDGEPVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKNIAKTKGSSGAGSRAGGGLPWGPRFPVESLWVPHIPPVEIHMFGASIIFLKYKSLPLPWLGKGLGWPEFMAWGRGSGGGGHPHPHSMLPNLQCL", "length": 394, "header": "tr|A0AAA9TTU4-1|GATA5_BOVIN Computationally mapped isoform of Transcription factor GATA-5 OS=Bos taurus OX=9913 GN=GATA5 PE=2 SV=1 CANONICAL=Q3SZJ5-1" }, "locus": { "chromosome": "13", "start_pos": 54807866, "end_pos": 54799621, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093309.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093309.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100795.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100795.1" } ] } }, { "isoform_ac": "Q3SZJ5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5/entry#Q3SZJ5-1", "sequence": { "sequence": "MYQSLALAPSPGQTAYADSGAFLHTPGAGSPVFVPPARVPSMLPYLPACEPGPQAPAITAHPGWAQAAAADSSAFGSGSPHAPAAPPPGTTAFPFAHSSPGPGGGTGTRDNGAFQGAMLAREQYPAALGRPVSSSYPTAYPAYMSAEVAPSWTSGPLDGSVLHSLQGLPAGLPGRRAPFAAELLEEFPGEGRECVNCGALSTPLWRRDGTGHYLCNACGLYHKMNGVNRPLVRPQKRLSSSRRAGLCCTNCHTTTTTLWRRNVDGEPVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKNIAKTKGSSGSSGHTTASPQASVPDPEVSAATLKPEPSLASPSCPGPSVTSQGSAQVDDPLAPSHLEFKFEPEDFALPSAALGQQAGLGGALRQEAWCALALA", "length": 403, "header": "sp|Q3SZJ5-1|GATA5_BOVIN Isoform 1 of Transcription factor GATA-5 OS=Bos taurus OX=9913 GN=GATA5 PE=2 SV=1 CANONICAL=Q3SZJ5-1" }, "locus": { "chromosome": "13", "start_pos": 54808499, "end_pos": 54799621, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027184.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027184.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027184.3", "url": "https://www.ensembl.org/id/ENSBTAP00000027184.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504784", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504784", "resource": "KEGG Pathway" }, { "id": "R-BTA-983231", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983231", "resource": "Reactome", "description": "Factors involved in megakaryocyte development and platelet production" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZPS1-1", "protein_name": "GATA binding protein 5", "gene_name": "GATA5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MYQGLALAPNHGQSAYSHDSGNFLHSSAGSPVYVPTTRVPSVLQTLPYLQSCEPHQSHLGNPPGWAQSSGETTAFNAGSPHPPSGFSYPHSPPGSSPPGRDGAYQGPLLLGGGGREQYGNALVRSVNGSYSSPYPAYVTPELPPSWTAGHFESSVLHSLQTRQAALPGRRSTFEYLEEFPGDGRECVNCGAMSTPLWRKDGTGHYLCNACGLYHKMNGINRPLKPQKRLSSSRRAGLCCTNCHTTNTTLWRRNAEGEPVCNACGLYMKLHGGTKTSGHEKGKHPDKEKEAEKHYQRQNLNRVHHFGHELPFFHYELRQHGHFKVRAQHNLTVPRTRHCVGVPGTEPVRRGAGRRRVQIRAGGLPLFSQQHGPAARAERATAAGLVVCPGARLEPLVPAAWLTMGRASLGGCGRKTPARWGAQRASPHPRRPRVASLRLPVFPQKAVLL", "length": 448 }, "evidence": [ { "id": "Q3SZJ5", "url": "https://omabrowser.org/oma/group/Q3SZJ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HGW9-1", "protein_name": "Transcription factor GATA-5", "gene_name": "Gata5", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MYQSLALAQSPGQATYADSGAFLHASGAGSPVFMAPTRVPSMLPYLPACEPGSQPPALAAHSSWTQATAADSSAFGSGSPHPPAAHPPGASTFPFAHSPPGPGSGGSAGARDSGSFQGALLAREQYATPLGRPMSASYPTTYPAYVSPDVAPSWTSGPFDGSSILHGLQGRPSGLPGRRATFVPDFLEEFPGEGRECVNCGALSTPLWRRDGTGHYLCNACGLYHKMNGVNRPLVRPQKRLSSTRRSGLCCSNCHTATTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKNPAKTKGSSGSTANTAASSSTLHNTEGSAATLKAEPSLASPVCTGPTISSQASSSPANESLAPNHLEFKFEPEDFAFTSSSLSPQAGLSGVLRQEAWCALALA", "length": 406 }, "evidence": [ { "id": "Q3SZJ5", "url": "https://omabrowser.org/oma/group/Q3SZJ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P97489-1", "protein_name": "Transcription factor GATA-5", "gene_name": "Gata5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYQSLALAQSPGQGTYADSGAFLHSSGTGSPVFVAPTRMPSMLPYLPSCEPGSQAPALAAHSSWTQAVAADSSAFGSGSPHPPAAHPPGATTFPFAHSPPGSGSGGSAGVRDGGAFQGALLAREQYPTPLGRPMGASYPTTYPAYMSSDVAPSWTSGAFDSSILHGLQARPGGLPGRRTSFVPDFLEEFPGEGRECVNCGALSTPLWRRDGTGHYLCNACGLYHKMNGVNRPLVRPQKRLSSSRRSGLCCSNCHTATTTLWRRNSEGEPVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKNPAKIKGSSGSTANTTASSPTLLNSESSATTLKAESSLASPVCAGPTITSQASSPADESLASSHLEFKFEPEDFAFTSSSMSPQAGLSGVLRQETWCALALA", "length": 404 }, "evidence": [ { "id": "Q3SZJ5", "url": "https://omabrowser.org/oma/group/Q3SZJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BWX5-1", "protein_name": "Transcription factor GATA-5", "gene_name": "GATA5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYQSLALAASPRQAAYADSGSFLHAPGAGSPMFVPPARVPSMLSYLSGCEPSPQPPELAARPGWAQTATADSSAFGPGSPHPPAAHPPGATAFPFAHSPSGPGSGGSAGGRDGSAYQGALLPREQFAAPLGRPVGTSYSATYPAYVSPDVAQSWTAGPFDGSVLHGLPGRRPTFVSDFLEEFPGEGRECVNCGALSTPLWRRDGTGHYLCNACGLYHKMNGVNRPLVRPQKRLSSSRRAGLCCTNCHTTNTTLWRRNSEGEPVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKTIAKARGSSGSTRNASASPSAVASTDSSAATSKAKPSLASPVCPGPSMAPQASGQEDDSLAPGHLEFKFEPEDFAFPSTAPSPQAGLRGALRQEAWCALALA", "length": 397 }, "evidence": [ { "id": "Q3SZJ5", "url": "https://omabrowser.org/oma/group/Q3SZJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 16, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "positive regulation of Notch signaling pathway", "id": "GO:0045747", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045747", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "cardiac muscle tissue development", "id": "GO:0048738", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048738", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "endocardial cushion fusion", "id": "GO:0003274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003274", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "aortic valve morphogenesis", "id": "GO:0003180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003180", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "cell fate commitment", "id": "GO:0045165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045165", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "negative regulation of cardiac muscle hypertrophy", "id": "GO:0010614", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010614", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "positive regulation of cardiac endothelial to mesenchymal transition", "id": "GO:0062000", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062000", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "heart induction", "id": "GO:0003129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003129", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "animal organ development", "id": "GO:0048513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048513", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ5", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZJ5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 403, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZJ5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZJ5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LL5-1", "uniprot_ac": "Q32LL5", "uniprot_id": "INT12_BOVIN", "mass": { "chemical_mass": 48557.0, "monoisotopic_mass": 48557.0 }, "refseq": { "ac": "NP_001069221", "name": "integrator complex subunit 12", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069221" }, "gene_names": [ { "name": "INTS12", "type": "recommended", "evidence": [ { "id": "Q32LL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LL5" } ] }, { "name": "INTS12", "type": "synonym", "evidence": [ { "id": "NP_001069221", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069221" } ] }, { "name": "PHF22", "type": "synonym", "evidence": [ { "id": "Q32LL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LL5" } ] } ], "protein_names": [ { "name": "Integrator complex subunit 12", "type": "recommended", "evidence": [ { "id": "Q32LL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LL5/entry#names_and_taxonomy" } ] }, { "name": "Int12", "type": "synonym", "evidence": [ { "id": "Q32LL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LL5/entry#names_and_taxonomy" } ] }, { "name": "PHD finger protein 22", "type": "synonym", "evidence": [ { "id": "NP_001069221", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069221" }, { "id": "Q32LL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LL5/entry#names_and_taxonomy" } ] }, { "name": "int12", "type": "synonym", "evidence": [ { "id": "NP_001069221", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069221" } ] }, { "name": "integrator complex subunit 12", "type": "synonym", "evidence": [ { "id": "NP_001069221", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069221" } ] } ], "function": [ { "annotation": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex.", "evidence": [ { "database": "UniProtKB", "id": "Q32LL5", "url": "https://www.uniprot.org/uniprotkb/Q32LL5#function" }, { "database": "UniProtKB", "id": "Q96CB8", "url": "https://www.uniprot.org/uniprotkb/Q96CB8#function" }, { "database": "UniProtKB", "id": "A0AAA9TX02", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX02#function" }, { "database": "UniProtKB", "id": "ARBA00057156", "url": "https://www.uniprot.org/uniprotkb/ARBA00057156#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LL5", "url": "https://www.uniprot.org/uniprotkb/Q32LL5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "INTS12", "url": "https://www.uniprot.org/uniprotkb/Q32LL5", "locus": { "chromosome": "6", "start_pos": 19477589, "end_pos": 19452815, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033648", "url": "https://www.ensembl.org/id/ENSBTAG00000033648" } ] } } ], "crossref": [ { "id": "Q32LL5", "url": "https://alphafold.ebi.ac.uk/entry/Q32LL5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033648", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033648", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15501", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15501", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517489", "url": "https://www.ncbi.nlm.nih.gov/gene/517489", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051776", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051776", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517489", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517489", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QECHCLY", "url": "https://omabrowser.org/oma/group/QECHCLY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32LL5", "url": "https://www.orthodb.org/?gene=Q32LL5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13415", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13415", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13415:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13415:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6807505", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807505", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001069221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069221", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TX02", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TX02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LL5", "url": "https://www.uniprot.org/uniprotkb/Q32LL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LL5-1", "url": "https://www.uniprot.org/uniprotkb/Q32LL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAVNLELDPIFLKALGFLHSKSKDSAEKLKTLLDESLARGIDSSYRPSQKDVEPPKISSTKTVSVKQEPKTSSSLPSGNNNGKVLTTEKVKKEGEKRPADKMKSDITEGADVPKKPRLEKPETRSSPITVQTSKDLAMADLSSFEETSADDFAMEMGLACVVCRQMTVASGNQLVECQECHNLYHQDCHKPQVTDKEVTDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPTVVSVAPAVKDPLVKKPETKLKPETTFLAFKRSEVKASTVVSGNSSSTNVSSSATSGLIGWAAFAAKTTSAGPSTAKLSSAAQNNSGKPATSSANQKPVGLTGLATTSKGGIGSKIGSSNSTSPTVPLKPPPPLTLGKTGLSRSVSCDNVSKVGLPSPSSLVPGSSSQLSGNGNSGTSGPSGSTTNKTASEPSTSPSASLKGPTSQESQLNAMKRLQMVKKKAAQKKLKK", "length": 462, "header": "sp|Q32LL5-1|INT12_BOVIN Isoform 1 of Integrator complex subunit 12 OS=Bos taurus OX=9913 GN=INTS12 PE=2 SV=1 CANONICAL=Q32LL5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TX02-1", "url": "https://www.uniprot.org/uniprotkb/Q32LL5/entry#A0AAA9TX02-1", "sequence": { "sequence": "MSKKVFGMAAAVNLELDPIFLKALGFLHSKSKDSAEKLKTLLDESLARGIDSSYRPSQKDVEPPKISSTKTVSVKQEPKTSSSLPSGNNNGKVLTTEKVKKEGEKRPADKMKSDITEGADVPKKPRLEKPETRSSPITVQTSKDLAMADLSSFEETSADDFAMEMGLACVVCRQMTVASGNQLVECQECHNLYHQDCHKPQVTDKEVTDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPTVVSVAPAVKDPLVKKPETKLKPETTFLAFKRSEVKASTVVSGNSSSTNVSSSATSGLIGWAAFAAKTTSAGPSTAKLSSAAQNNSGKPATSSANQKPVGLTGLATTSKGGIGSKIGSSNSTSPTVPLKPPPPLTLGKTGLSRSVSCDNVSKVGLPSPSSLVPGSSSQLSGNGNSGTSGPSGSTTNKTASEPSTSPSASLKGPTSQESQLNAMKRLQMVKKKAAQKKLKK", "length": 469, "header": "tr|A0AAA9TX02-1|INT12_BOVIN Computationally mapped isoform of Integrator complex subunit 12 OS=Bos taurus OX=9913 GN=INTS12 PE=2 SV=1 CANONICAL=Q32LL5-1" }, "locus": { "chromosome": "6", "start_pos": 19477486, "end_pos": 19458285, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102069.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102069.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101721.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101721.1" } ] } }, { "isoform_ac": "Q32LL5-1", "url": "https://www.uniprot.org/uniprotkb/Q32LL5/entry#Q32LL5-1", "sequence": { "sequence": "MAAAVNLELDPIFLKALGFLHSKSKDSAEKLKTLLDESLARGIDSSYRPSQKDVEPPKISSTKTVSVKQEPKTSSSLPSGNNNGKVLTTEKVKKEGEKRPADKMKSDITEGADVPKKPRLEKPETRSSPITVQTSKDLAMADLSSFEETSADDFAMEMGLACVVCRQMTVASGNQLVECQECHNLYHQDCHKPQVTDKEVTDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPTVVSVAPAVKDPLVKKPETKLKPETTFLAFKRSEVKASTVVSGNSSSTNVSSSATSGLIGWAAFAAKTTSAGPSTAKLSSAAQNNSGKPATSSANQKPVGLTGLATTSKGGIGSKIGSSNSTSPTVPLKPPPPLTLGKTGLSRSVSCDNVSKVGLPSPSSLVPGSSSQLSGNGNSGTSGPSGSTTNKTASEPSTSPSASLKGPTSQESQLNAMKRLQMVKKKAAQKKLKK", "length": 462, "header": "sp|Q32LL5-1|INT12_BOVIN Isoform 1 of Integrator complex subunit 12 OS=Bos taurus OX=9913 GN=INTS12 PE=2 SV=1 CANONICAL=Q32LL5-1" }, "locus": { "chromosome": "6", "start_pos": 19477486, "end_pos": 19460106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047799.6", "url": "https://www.ensembl.org/id/ENSBTAT00000047799.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044968.3", "url": "https://www.ensembl.org/id/ENSBTAP00000044968.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 128, "end_pos": 128, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LL5", "url": "https://www.uniprot.org/uniprotkb/Q32LL5" } ], "site_lbl": "Ser128" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517489", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517489", "resource": "KEGG Pathway" }, { "id": "R-BTA-6807505", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807505", "resource": "Reactome", "description": "RNA polymerase II transcribes snRNA genes" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7F5G4-1", "protein_name": "Integrator complex subunit 12", "gene_name": "Ints12", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPVFAMAATVNLELDPIFLKALGFLHSKSKDSAEKLKALLDESLARGIDSSYRPAQKDVEPPKISSTKSISIKQEPKASSSLPSGSSNGKALATEKIKKEAEKRPADKMKDVTEGVDIPKKPRLEKPETRSSPITVQTSKDLAMADLSSFEETSADDFAMEMGLACVVCRQMTVASGNQLVECQECHNLYHQDCHKPQVTDKEVNDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPTVVSVAPAVKDPLVKKPETKLKQETAFLAFKRAEVKPPTVISGNSSGNNVSSSVTSGLTGWAAFAAKTSSAGPSTAKLNSTAQNNSGKPAASSANQKPVGLTSLATSSKGGLGSKLGSGNSSSPSVPLKPLPPLTLGKTGLSRSVSCDNVSKAGLPSPSSLVPGGSGQVSGNGSSAASGPSGSATSKTTPEPSSGPSASLKGPTSQESQLNAMKRLQMVKKKAAQKKLKK", "length": 466 }, "evidence": [ { "id": "Q32LL5", "url": "https://omabrowser.org/oma/group/Q32LL5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E1C843-1", "protein_name": "Integrator complex subunit 12", "gene_name": "INTS12", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAAVNMELDPIFLKALGFLRSKSKDSAEKLKALLDESLARGADSSYRPSQKEVEQPKVCVTKPVSSKQDPKASSSLPSGNNNGKPTASEKVKKETEKRSSDKMKGDTAEGADVPKKPRLEKQEARSSPITVQTSKDLSMPDLSSFEETSADDFAMEMGLACVVCRQMTVISGNQLVECQECHNLYHQDCHKPQVTDKEVNDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPAVVSVEPAVKDPLVKKSEIKLKPETQTTFLAFKRTEVKPSAAVSGNSASTSVSSSATTSGLTGWAAFAARNSSANPSTAKLGSTAQSAGGKPAAASNNQKPVGLSGLAASKTGLGSKIASANNSTSPVQLKPPPPLTLGKTTLSRSVSSDNVSKVGLPSPSSTVPSTSSQVSSGNGNSGTASNSGGNASKTTADAGNQSASLKGPTSQESQLNAMKRLQMVKKKAAQKKLKK", "length": 464 }, "evidence": [ { "id": "Q32LL5", "url": "https://omabrowser.org/oma/group/Q32LL5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3LT26-1", "protein_name": "Integrator complex subunit 12", "gene_name": "INTS12", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAAVNLELDPIFLKALGFLHSKSKDSAEKLKALLDESLARGIDSSYRPSPKDMEPPKISSTKTVSVKQEPKTTSSLPSGNNNGKVLTTEKVKKEGEKRPADKMKSDVTEGADIPKKPRLEKPETRSSPITVQTSKDLAIADLSSFEETSADDFAMEMGLACVVCRQMTVASGNQLVECQECHNLYHQDCHKPQVTDKEVNDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPTVVSVAPAVKDPLVKKPETKLKQETAFLAFKRAEVKTSTLLSGNSSGTNVSSSATSGLIGWAAFAAKTTSGGPSTAKLNSTTQNNSGKPATSSANQKPVGLTGLATSSKGGIGSKIGSSNSTSPTVPLKPPPPLTLGKTGLSRSVSCDNVSKVGLPSPSSLVPGSSSQLSGNGNSGTSGPSGSTTNKTTSESSSSPLASLKGPTSQESQLNAMKRLQMVKKKAAQKKLKK", "length": 462 }, "evidence": [ { "id": "Q32LL5", "url": "https://omabrowser.org/oma/group/Q32LL5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q68FR3-1", "protein_name": "Integrator complex subunit 12", "gene_name": "Ints12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAATVNLELDPIFLKALGFLHSKSKDSAEKLKTLLDESLARGIDASYRPAQKDVEPPKISSTKSLSIKQEPKTSSSLPSGSSNGKVLAAEKLKKEAEKRPADKMKDATEGVDVPKKPRLEKPETRSSPITVQTSKDLAMADLSSFEETSADDFAMEMGLACVVCRQMTVASGNQLVECQECHNLYHQDCHKPQVTDKEVNDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPTVVSVAPTVKDPLVKKPETKLKQETTFLAFKRTEVKPSTVISGNSSSNNVSSSVTSGLTGWAAFAAKTSSAGPSTAKLNSTAQNSSGKPAASSASQKPVGLTGLATSSKGGIGSKIGSSNSTSPSVPLKPLPPLTLGKTGLSRSVSCDNVSKVGLPSPSSLVPGGSSQLSGNGNSATAGPTGSITSKTTSETSSSTSASLKGPTSQESQLNAMKRLQMVKKKAAQKKLKK", "length": 461 }, "evidence": [ { "id": "Q32LL5", "url": "https://omabrowser.org/oma/group/Q32LL5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6IQU7-1", "protein_name": "Integrator complex subunit 12", "gene_name": "ints12", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAGTVSLELDPIFLKGLGYLHSKSKDSAEKLKALLDESLARGSDSIYRNSIKEAEVSKVSLPKMTKQDSKSSSSSSASSSITTTSSSKSSTSEKSKKESEKRTLEKIRVDPGEGVEPPKKPRLEKQDSHSSPIAFQTKDIPIPDFTDIDETNADDFAMEMGLACVVCRQMTVTSGNQLVECQECHNLYHQECHKPQVTDKDVNDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPALATTVPLLKDPLVKKAELKPKPETTGSFQAFKRTEVKATAASGNSSSSSSSSSSLPPGLTGWAAFTKATSNVGPSSTKLSTSQSGNSKTSPAASGSKPVGLSALANVKPALATKPSGGSSAGSGNGNNGSGTVPLKAPPPLTLGKQVLSRSASGDSLGKMTVTGSLSPGAAPSSSLGGNGGSGGNGAGNGGNSAGSSSSSGNNNNNGAKASADGKAPTSQESQLNAMKRLQMVKKKAAQKKLKK", "length": 479 }, "evidence": [ { "id": "Q32LL5", "url": "https://omabrowser.org/oma/group/Q32LL5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q96CB8-1", "protein_name": "Integrator complex subunit 12", "gene_name": "INTS12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAATVNLELDPIFLKALGFLHSKSKDSAEKLKALLDESLARGIDSSYRPSQKDVEPPKISSTKNISIKQEPKISSSLPSGNNNGKVLTTEKVKKEAEKRPADKMKSDITEGVDIPKKPRLEKPETQSSPITVQSSKDLPMADLSSFEETSADDFAMEMGLACVVCRQMMVASGNQLVECQECHNLYHRDCHKPQVTDKEANDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPAVVSVTPAVKDPLVKKPETKLKQETTFLAFKRTEVKTSTVISGNSSSASVSSSVTSGLTGWAAFAAKTSSAGPSTAKLSSTTQNNTGKPATSSANQKPVGLTGLATSSKGGIGSKIGSNNSTTPTVPLKPPPPLTLGKTGLSRSVSCDNVSKVGLPSPSSLVPGSSSQLSGNGNSGTSGPSGSTTSKTTSESSSSPSASLKGPTSQESQLNAMKRLQMVKKKAAQKKLKK", "length": 462 }, "evidence": [ { "id": "Q32LL5", "url": "https://omabrowser.org/oma/group/Q32LL5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D168-1", "protein_name": "Integrator complex subunit 12", "gene_name": "Ints12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAATVNLELDPIFLKALGFLHSKSKDSAEKLKALLDESLARGIDSSYRPTQKDVEPPKISSTKSLSIKQEPKTSSSLPSGSSNGKVLTAEKIKKEAEKRPADKMKDVTEGIDVPKKPRLEKPETRSSPITVQTSKDLSMADLSSFEETSADDFAMEMGLACVVCRQMTVASGNQLVECQECHNLYHQDCHKPQVTDKEVNDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPTVVSVTPTVKDPLVKKPETKLKQETTFLAFKRTEVKPSTVISGNSSSNNVSSSVTSGLTGWAAFAAKTSSAGPSTAKLNSAAQNSSGKPAASSSNQKPVGLTGLATSSKGGIGSKIGSGNSTSPSVPLKPLPPLTLGKTGLSRSVSCDNVSKVGLPSPSSLVPGGSSQLSGNGNSATTGPSGSTTSKATSETSSSTSASLKGPTSQESQLNAMKRLQMVKKKAAQKKLKK", "length": 461 }, "evidence": [ { "id": "Q32LL5", "url": "https://omabrowser.org/oma/group/Q32LL5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32LL5", "url": "https://www.uniprot.org/uniprotkb/Q32LL5" } ], "pmid": "" }, { "name": "integrator complex", "id": "GO:0032039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032039", "evidence": [ { "database": "UniProtKB", "id": "Q32LL5", "url": "https://www.uniprot.org/uniprotkb/Q32LL5" } ], "pmid": "" }, { "name": "INTAC complex", "id": "GO:0160232", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160232", "evidence": [ { "database": "UniProtKB", "id": "Q32LL5", "url": "https://www.uniprot.org/uniprotkb/Q32LL5" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "Q32LL5", "url": "https://www.uniprot.org/uniprotkb/Q32LL5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q32LL5", "url": "https://www.uniprot.org/uniprotkb/Q32LL5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "snRNA 3'-end processing", "id": "GO:0034472", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034472", "evidence": [ { "database": "UniProtKB", "id": "Q32LL5", "url": "https://www.uniprot.org/uniprotkb/Q32LL5" } ], "pmid": "" }, { "name": "RNA polymerase II transcription initiation surveillance", "id": "GO:0160240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160240", "evidence": [ { "database": "UniProtKB", "id": "Q32LL5", "url": "https://www.uniprot.org/uniprotkb/Q32LL5" } ], "pmid": "" }, { "name": "regulation of transcription elongation by RNA polymerase II", "id": "GO:0034243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034243", "evidence": [ { "database": "UniProtKB", "id": "Q32LL5", "url": "https://www.uniprot.org/uniprotkb/Q32LL5" } ], "pmid": "" }, { "name": "snRNA processing", "id": "GO:0016180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016180", "evidence": [ { "database": "UniProtKB", "id": "Q32LL5", "url": "https://www.uniprot.org/uniprotkb/Q32LL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 281, "end_pos": 283, "annotation": "n_glycosylation_sequon" }, { "start_pos": 316, "end_pos": 318, "annotation": "n_glycosylation_sequon" }, { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 381, "end_pos": 383, "annotation": "n_glycosylation_sequon" }, { "start_pos": 418, "end_pos": 420, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LL5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 462, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LL5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LL5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 128 ], "sequon_annotation_sites": [ { "start_pos": 276, "end_pos": 278 }, { "start_pos": 281, "end_pos": 283 }, { "start_pos": 316, "end_pos": 318 }, { "start_pos": 352, "end_pos": 354 }, { "start_pos": 381, "end_pos": 383 }, { "start_pos": 418, "end_pos": 420 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBK8-1", "uniprot_ac": "Q2TBK8", "uniprot_id": "SPN1_BOVIN", "mass": { "chemical_mass": 41492.0, "monoisotopic_mass": 41492.0 }, "refseq": { "ac": "NP_001033635", "name": "snurportin-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033635" }, "gene_names": [ { "name": "SNUPN", "type": "recommended", "evidence": [ { "id": "Q2TBK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8" } ] }, { "name": "RNUT1", "type": "synonym", "evidence": [ { "id": "NP_001033635", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033635" }, { "id": "Q2TBK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8" } ] }, { "name": "SNUPN", "type": "synonym", "evidence": [ { "id": "NP_001033635", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033635" } ] } ], "protein_names": [ { "name": "Snurportin-1", "type": "recommended", "evidence": [ { "id": "Q2TBK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8/entry#names_and_taxonomy" } ] }, { "name": "RNA U transporter 1", "type": "synonym", "evidence": [ { "id": "Q2TBK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8/entry#names_and_taxonomy" } ] }, { "name": "RNA, U transporter 1", "type": "synonym", "evidence": [ { "id": "NP_001033635", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033635" } ] }, { "name": "snurportin-1", "type": "synonym", "evidence": [ { "id": "NP_001033635", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033635" } ] } ], "function": [ { "annotation": "Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TXL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXL0#function" }, { "database": "UniProtKB", "id": "ARBA00003975", "url": "https://www.uniprot.org/uniprotkb/ARBA00003975#function" }, { "database": "UniProtKB", "id": "A0AAF7AEI7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEI7#function" }, { "database": "UniProtKB", "id": "Q2TBK8", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8#function" }, { "database": "UniProtKB", "id": "O95149", "url": "https://www.uniprot.org/uniprotkb/O95149#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBK8", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNUPN", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8", "locus": { "chromosome": "21", "start_pos": 33291567, "end_pos": 33274068, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021293", "url": "https://www.ensembl.org/id/ENSBTAG00000021293" } ] } } ], "crossref": [ { "id": "Q2TBK8", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBK8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021293", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021293", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09232", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09232", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515588", "url": "https://www.ncbi.nlm.nih.gov/gene/515588", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017336", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017336", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024721", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024721", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515588", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515588", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ENWIMVP", "url": "https://omabrowser.org/oma/group/ENWIMVP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBK8", "url": "https://www.orthodb.org/?gene=Q2TBK8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13403", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13403", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13403:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13403:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11538", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11538", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21974", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21974", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-191859", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-191859", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001033635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033635", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TXL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXL0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AEI7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AEI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AEI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBK8", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBK8-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEELSQALAGSFSVSQDLNSTAAPHPRLSQYKSKYSSLEQSERRRQLLELQKLKRLDYVNHARRLAEDDWTGMESEEEEEKKDDEEMDVDTGKELPKRYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRSLIVASQGLTSAYTKSGYCVNTFPSLLPGGNRRNSTTEKDYTILDCIYSEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWLHSKLPEEEGLGEKTKRNPFKFVGLKNFPCTPESLCKVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDVLGVAVPACPLTTKPEYAGYQLQQIIEHKKSKKEGIMGKLTPRASENGHYELEHLSTPKLKSPPQRPNHPESLMEN", "length": 362, "header": "sp|Q2TBK8-1|SPN1_BOVIN Isoform 1 of Snurportin-1 OS=Bos taurus OX=9913 GN=SNUPN PE=2 SV=1 CANONICAL=Q2TBK8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TXL0-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8/entry#A0AAA9TXL0-1", "sequence": { "sequence": "MEELSQALAGSFSVSQDLNSTAAPHPRLSQYKSKYSSLEQSERRRQLLELQKLKRLDYVNHARRLAEDDWTGMESEEEEEKKDDEEMDVDTGKELPKRYANQGLTSAYTKSGYCVNTFPSLLPGGNRRNSTTEKDYTILDCIYSEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWLHSKLPEEEGLGEKTKRNPFKFVGLKNFPCTPESLCKVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDVLGVAVPACPLTTKPEYAGYQLQQIIEHKKSKKEGIMGKLTPRASENGHYELEHLSTPKLKSPPQRPNHPESLMEN", "length": 327, "header": "tr|A0AAA9TXL0-1|SPN1_BOVIN Computationally mapped isoform of Snurportin-1 OS=Bos taurus OX=9913 GN=SNUPN PE=2 SV=1 CANONICAL=Q2TBK8-1" }, "locus": { "chromosome": "21", "start_pos": 33291305, "end_pos": 33276893, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122083.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122083.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101386.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101386.1" } ] } }, { "isoform_ac": "A0AAF7AEI7-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8/entry#A0AAF7AEI7-1", "sequence": { "sequence": "MVWVGSPSETGASPWAGFNSQVPGCLARTPRGTFVGEGRVMHSSIEKNSAGMWRGGLSSGAGKMEELSQALAGSFSVSQDLNSTAAPHPRLSQYKSKYSSLEQSERRRQLLELQKLKRLDYVNHARRLAEDDWTGMESEEEEEKKDDEEMDVDTGKELPKRYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRSLIVASQGLTSAYTKSGYCVNTFPSLLPGGNRRNSTTEKDYTILDCIYSEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWLHSKLPEEEGLGEKTKRNPFKFVGLKNFPCTPESLCKVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDVLGVAVPACPLTTKPEYAGYQLQQIIEHKKSKKEGIMGKLTPRASENGHYELEHLSTPKLKSPPQRPNHPESLMEN", "length": 425, "header": "tr|A0AAF7AEI7-1|SPN1_BOVIN Computationally mapped isoform of Snurportin-1 OS=Bos taurus OX=9913 GN=SNUPN PE=2 SV=1 CANONICAL=Q2TBK8-1" }, "locus": { "chromosome": "21", "start_pos": 33291305, "end_pos": 33276893, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076267.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076267.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067932.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067932.2" } ] } }, { "isoform_ac": "Q2TBK8-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8/entry#Q2TBK8-1", "sequence": { "sequence": "MEELSQALAGSFSVSQDLNSTAAPHPRLSQYKSKYSSLEQSERRRQLLELQKLKRLDYVNHARRLAEDDWTGMESEEEEEKKDDEEMDVDTGKELPKRYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRSLIVASQGLTSAYTKSGYCVNTFPSLLPGGNRRNSTTEKDYTILDCIYSEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWLHSKLPEEEGLGEKTKRNPFKFVGLKNFPCTPESLCKVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDVLGVAVPACPLTTKPEYAGYQLQQIIEHKKSKKEGIMGKLTPRASENGHYELEHLSTPKLKSPPQRPNHPESLMEN", "length": 362, "header": "sp|Q2TBK8-1|SPN1_BOVIN Isoform 1 of Snurportin-1 OS=Bos taurus OX=9913 GN=SNUPN PE=2 SV=1 CANONICAL=Q2TBK8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 75, "end_pos": 75, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK8", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8" } ], "site_lbl": "Ser75" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515588", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515588", "resource": "KEGG Pathway" }, { "id": "R-BTA-191859", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-191859", "resource": "Reactome", "description": "snRNP Assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1TQ71-1", "protein_name": "Snurportin-1", "gene_name": "SNUPN", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEELSQALASSFSVSQDLNSTAAPHPRLSQYKSKYSSLEQSERRRRLLELQKSKRQDYVNHARRLAENDWTGMESEEEEEKKDDEEMDIDIGKKLPKHYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRALIVASRGSTSAYTKSGYCVNRFSSLLPGGNRRNSTTAKDYTILDCIYSEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWMHSKLPEEEGLGEKTKLNPFKFVGLKNFPCTPESLCEVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDVLGVAVPAGPLTTKPEYAGHQLQQIIEHKRSQREGLKEKLTHKASENGCYELEHLSTPKLKSPPQSLDPPGSLMEN", "length": 362 }, "evidence": [ { "id": "Q2TBK8", "url": "https://omabrowser.org/oma/group/Q2TBK8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2LGB4-1", "protein_name": "Snurportin-1", "gene_name": "Snupn", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEELSQALAGSFSVSQELNSTAAPHPRLSQYKSKYCSLEQSERRRQLLELQKSKRLDYVNHARRLAEDDWTGMESGEEDKKEEEEMDIDPGKKLPKRYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRALIVASRGSTSAYTKSGYCVNRFSSLLPGGNRRNSTTAKDYTILDCIYSEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWMHSKLPEEEGLGEKTKINPFKFVGLKNYPCTPESLCKVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDILGVAVPAGPLTTKPEYAGHQLQQIIEHKRSQEDMKDKFSHKASENGHYELEHLSTPKLKSPPHSPGNLMDN", "length": 357 }, "evidence": [ { "id": "Q2TBK8", "url": "https://omabrowser.org/oma/group/Q2TBK8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "B7Z0I7-1", "protein_name": "Snurportin-1", "gene_name": "Snup", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MESSFQELYKKGLDIGEQQKQRQKELLKQQKLRRQQEQDDYRPLQNQEKPVPRKKSGKRSGHQKGIPYRPQLSEWLRHKPDDLNEWLLVPCPVGKRCLVVASKGITKAYSKGGWMFVNFRSSLPGDWQLQKGETILDCVYVEDADTFYVLDAISFGLQEVQECEASFRFYWLRARFEEHDYDKISENNEKKFKLLDHFDFEDPSAVEQALHKYPFFPENKPDLDGFLFYHKEASYVCRETPLVCWLFPFMMEDVLGLPVNKCYKAPEDYQPSHVLQYMDAFEQKLAEHRRTLKEQKKKVNEQKEDPHTMEAEEDVESDEYDSLKRVLDQQRRLELGEFDMDCAEPPSADGC", "length": 351 }, "evidence": [ { "id": "Q2TBK8", "url": "https://omabrowser.org/oma/group/Q2TBK8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "O95149-1", "protein_name": "Snurportin-1", "gene_name": "SNUPN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEELSQALASSFSVSQDLNSTAAPHPRLSQYKSKYSSLEQSERRRRLLELQKSKRLDYVNHARRLAEDDWTGMESEEENKKDDEEMDIDTVKKLPKHYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRALIVASRGSTSAYTKSGYCVNRFSSLLPGGNRRNSTAKDYTILDCIYNEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWMHSKLPEEEGLGEKTKLNPFKFVGLKNFPCTPESLCDVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDVLGVAVPAGPLTTKPDYAGHQLQQIMEHKKSQKEGMKEKLTHKASENGHYELEHLSTPKLKGSSHSPDHPGCLMEN", "length": 360 }, "evidence": [ { "id": "Q2TBK8", "url": "https://omabrowser.org/oma/group/Q2TBK8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5ZI43-1", "protein_name": "Snurportin-1", "gene_name": "SNUPN", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEELCAALAGGVALAAPNSPAAPHPRLSAYKGRGDRLGQAERRRRLLCLQRERRLDYVNHARRLAEGDWAGVESDEDGGEDGDGEEEMEVDAGRRLPKRYANQLMLSEWLVDVPVDLEQEWIVVVCPVGKRALVVASRGSTAAYTKSGFCVNRFPSLLPGGNRHNTMNEKVYCILDCIYNEAEQTYYILDVMCWRGHPVYDCQTDFRFFWLSSKIQEEEGLGEKSRINPYKFVGLQNFPCTSESLCEVLTTNFPFEVDGLLFYHKQTHYTPGSTPLVGWLRPYMVPDILGLTVPATPLTAKPDYAGRQLQQIIESKRSKKLAAGKAQPSAEAAARNGHYELEHLSTPQPANSAQGQEEAGSQMEN", "length": 365 }, "evidence": [ { "id": "Q2TBK8", "url": "https://omabrowser.org/oma/group/Q2TBK8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q68FP5-1", "protein_name": "Snurportin-1", "gene_name": "Snupn", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEELSQALASSFSVSQELNSTAAPHPRLSQYKSKYSSLEQSERRRQLLELQKSKRLDYVNHARRLAEDDWTGMESGEEEKKKDEEEMDLDPVKKLPKRYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRALIVASRGSTSAYTKSGYCVNRFSSLLPGGNRRNSTTAKDYTILDCIYSEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWMNSKLPEEEGLGEKTKINPFKFVGLKNFPCTPESLCKVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDILGVAVPAGPLTTKPEYAGHQLQQIIEHKRSQEDTKEKLTHKASENGHYELEHLSTPKLRSPPHSSESLMDS", "length": 358 }, "evidence": [ { "id": "Q2TBK8", "url": "https://omabrowser.org/oma/group/Q2TBK8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80W37-1", "protein_name": "Snurportin-1", "gene_name": "Snupn", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEELSQALASSFSVSQELNSTAAPHPRLCQYKSKYSSLEQSERRRQLLELQKSKRLDYVNHARRLAEDDWTGMESGEEENKKDEEEMDIDPSKKLPKRYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRALIVASRGSTSAYTKSGYCVNRFSSLLPGGNRRNSTTAKDYTILDCIYSEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWMHSKLPEEEGLGEKTKINPFKFVGLKNFPCTPESLCEVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDILGVAVPAGPLTTKPEYAGHQLQQIIEHKRSQEDTKEKLTHKASENGHYELEHLSTPKLRNPPHSSESLMDN", "length": 358 }, "evidence": [ { "id": "Q2TBK8", "url": "https://omabrowser.org/oma/group/Q2TBK8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "snRNA import into nucleus", "id": "GO:0061015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061015", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK8", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8" } ], "pmid": "" }, { "name": "protein complex oligomerization", "id": "GO:0051259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051259", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK8", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8" } ], "pmid": "" }, { "name": "protein tetramerization", "id": "GO:0051262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051262", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK8", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8" } ], "pmid": "" }, { "name": "cytoskeleton organization", "id": "GO:0007010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK8", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8" } ], "pmid": "" }, { "name": "RNA import into nucleus", "id": "GO:0006404", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006404", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK8", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8" } ], "pmid": "" }, { "name": "protein import into nucleus", "id": "GO:0006606", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006606", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK8", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK8", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8" } ], "pmid": "" }, { "name": "nuclear pore", "id": "GO:0005643", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005643", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK8", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK8", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK8", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK8", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA cap binding", "id": "GO:0000339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000339", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK8", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8" } ], "pmid": "" }, { "name": "nuclear import signal receptor activity", "id": "GO:0061608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061608", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK8", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK8", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 182, "end_pos": 184, "annotation": "n_glycosylation_sequon" }, { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBK8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 362, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBK8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBK8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2TBK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBK8" }, { "id": "PRU00561", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00561" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IBB", "eco_id": "ECO_0000255", "start_pos": 11, "end_pos": 73, "start_aa": "Ser", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 75 ], "sequon_annotation_sites": [ { "start_pos": 164, "end_pos": 166 }, { "start_pos": 182, "end_pos": 184 }, { "start_pos": 19, "end_pos": 21 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2NKY9-1", "uniprot_ac": "Q2NKY9", "uniprot_id": "JAGN1_BOVIN", "mass": { "chemical_mass": 21102.0, "monoisotopic_mass": 21102.0 }, "refseq": { "ac": "NP_001039915", "name": "protein jagunal homolog 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039915" }, "gene_names": [ { "name": "JAGN1", "type": "recommended", "evidence": [ { "id": "Q2NKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9" } ] }, { "name": "JAGN1", "type": "synonym", "evidence": [ { "id": "NP_001039915", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039915" } ] } ], "protein_names": [ { "name": "Protein jagunal homolog 1", "type": "recommended", "evidence": [ { "id": "Q2NKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9/entry#names_and_taxonomy" } ] }, { "name": "protein jagunal homolog 1", "type": "synonym", "evidence": [ { "id": "NP_001039915", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039915" } ] } ], "function": [ { "annotation": "Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils.", "evidence": [ { "database": "UniProtKB", "id": "Q2NKY9", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9#function" }, { "database": "UniProtKB", "id": "Q8N5M9", "url": "https://www.uniprot.org/uniprotkb/Q8N5M9#function" }, { "database": "UniProtKB", "id": "Q5XKN4", "url": "https://www.uniprot.org/uniprotkb/Q5XKN4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NKY9", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "JAGN1", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9", "locus": { "chromosome": "22", "start_pos": 16857182, "end_pos": 16859982, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010832", "url": "https://www.ensembl.org/id/ENSBTAG00000010832" } ] } } ], "crossref": [ { "id": "Q2NKY9", "url": "https://alphafold.ebi.ac.uk/entry/Q2NKY9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010832", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010832", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539101", "url": "https://www.ncbi.nlm.nih.gov/gene/539101", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539101", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539101", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PYGVLWY", "url": "https://omabrowser.org/oma/group/PYGVLWY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NKY9", "url": "https://www.orthodb.org/?gene=Q2NKY9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20955", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20955", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20955:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20955:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07086", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07086", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039915", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TY42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY42-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NKY9", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NKY9-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASRAGPRAAGTDGSDFQHRERVAMHYQMSVTLKYEIKKLIYVHLVIWLLLVAKMSVGHLRLLSHDQVAMPYQWEYPYLLSVVPSLLGLLSFPRNNISYLVLSMISMGLFSIAPLIYGSMEMFPAAQQLYRHGKAYRFLFGFSAVSVMYLVLVLAVQVHAWQLYYSKKLLDSWFTSTQEKKRK", "length": 183, "header": "sp|Q2NKY9-1|JAGN1_BOVIN Isoform 1 of Protein jagunal homolog 1 OS=Bos taurus OX=9913 GN=JAGN1 PE=2 SV=1 CANONICAL=Q2NKY9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TY42-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9/entry#A0AAA9TY42-1", "sequence": { "sequence": "MASRAGPRAAGTDGSDFQHRERVAMHYQMRLPYLYLYPCVQYNCLTYSWS", "length": 50, "header": "tr|A0AAA9TY42-1|JAGN1_BOVIN Computationally mapped isoform of Protein jagunal homolog 1 OS=Bos taurus OX=9913 GN=JAGN1 PE=2 SV=1 CANONICAL=Q2NKY9-1" }, "locus": { "chromosome": "22", "start_pos": 16859940, "end_pos": 16858182, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088334.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088334.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102111.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102111.1" } ] } }, { "isoform_ac": "Q2NKY9-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9/entry#Q2NKY9-1", "sequence": { "sequence": "MASRAGPRAAGTDGSDFQHRERVAMHYQMSVTLKYEIKKLIYVHLVIWLLLVAKMSVGHLRLLSHDQVAMPYQWEYPYLLSVVPSLLGLLSFPRNNISYLVLSMISMGLFSIAPLIYGSMEMFPAAQQLYRHGKAYRFLFGFSAVSVMYLVLVLAVQVHAWQLYYSKKLLDSWFTSTQEKKRK", "length": 183, "header": "sp|Q2NKY9-1|JAGN1_BOVIN Isoform 1 of Protein jagunal homolog 1 OS=Bos taurus OX=9913 GN=JAGN1 PE=2 SV=1 CANONICAL=Q2NKY9-1" }, "locus": { "chromosome": "22", "start_pos": 16859940, "end_pos": 16857671, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030816.4", "url": "https://www.ensembl.org/id/ENSBTAT00000030816.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030786.2", "url": "https://www.ensembl.org/id/ENSBTAP00000030786.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 3, "end_pos": 3, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2NKY9", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9" } ], "site_lbl": "Ser3" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539101", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539101", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5P4Q8-1", "protein_name": "Protein jagunal homolog 1", "gene_name": "JAGN1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASRGGPRAAGTDGSDYRHRERVASHYQMSVALKSEIKKLTYVHVGLWLLLLAQMCVGHLKLLPHDRVAMPYQWEYPYLLSILPSLLGLLSFPRNNISYLVLSMISAGLFSVAPLIYGAMEMFPMAQQLYRHGKAYRFIFGFSAVSVMYLVVVVAAQVHGWQLYYSKKLLDSWFTSTQEKKKK", "length": 183 }, "evidence": [ { "id": "Q2NKY9", "url": "https://omabrowser.org/oma/group/Q2NKY9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3GXA5-1", "protein_name": "Protein jagunal homolog 1", "gene_name": "Jagn1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASRAGPRAAGTDGSDFQHRERVAMHYQMSVTLKSEIKKLIYVHLVIWLLLVAKMCVGHLRLLSHDQVAMPYQWEYPYLLSIVPSLLGLLSFPRNNISYLVLSMISMGLFSIAPLIYGSMEMFPAAQQLYRHGKAYRFLFGFSAVSVMYLVLILAVQVHAWQLYYSKKLLDSWFTSTQEKKRK", "length": 183 }, "evidence": [ { "id": "Q2NKY9", "url": "https://omabrowser.org/oma/group/Q2NKY9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q4KM64-1", "protein_name": "Protein jagunal homolog 1", "gene_name": "Jagn1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASRAGPRAAGTDGSDFQHRERVAMHYQMSVTLKYEIKKLIYVHLVIWLLLVAKMSVGHLRLLSHDQVAMPYQWEYPYLLSIVPSVLGLLSFPRNNISYLVLSMISMGLFSIAPLIYGSMEMFPAAQQLYRHGKAYRFLFGFSAVSVMYLVLVLAVQVHAWQLYYSKKLLDSWFTSTQEKKRK", "length": 183 }, "evidence": [ { "id": "Q2NKY9", "url": "https://omabrowser.org/oma/group/Q2NKY9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5XKN4-1", "protein_name": "Protein jagunal homolog 1", "gene_name": "Jagn1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASRAGPRAAGTDGSDFQHRERVAMHYQMSVTLKYEIKKLIYVHLVIWLLLVAKMSVGHLRLLSHDQVAMPYQWEYPYLLSIVPSVLGLLSFPRNNISYLVLSMISMGLFSIAPLIYGSMEMFPAAQQLYRHGKAYRFLFGFSAVSVMYLVLVLAVQVHAWQLYYSKKLLDSWFTSTQEKKRK", "length": 183 }, "evidence": [ { "id": "Q2NKY9", "url": "https://omabrowser.org/oma/group/Q2NKY9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7K1V5-1", "protein_name": "Protein jagunal", "gene_name": "jagn", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MATRGGPMVAGTDGNDFEFRQRVAGTYQISLLNKSRLKYCIFFHALLFFVMLAKLTSDILDHLDIFVLEIEELEVPPPLWWEYVWAASLLTSFLGLSAARGNKVREMQKYMVAILLFAILPLFYCFAYYFSDVWEFATLDKSVELDETDIFVWRGYPYGVFWYAFCFVGFQVHGFTLYFAYNLVKAWKARTATRKFQ", "length": 197 }, "evidence": [ { "id": "Q2NKY9", "url": "https://omabrowser.org/oma/group/Q2NKY9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q8N5M9-1", "protein_name": "Protein jagunal homolog 1", "gene_name": "JAGN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASRAGPRAAGTDGSDFQHRERVAMHYQMSVTLKYEIKKLIYVHLVIWLLLVAKMSVGHLRLLSHDQVAMPYQWEYPYLLSILPSLLGLLSFPRNNISYLVLSMISMGLFSIAPLIYGSMEMFPAAQQLYRHGKAYRFLFGFSAVSIMYLVLVLAVQVHAWQLYYSKKLLDSWFTSTQEKKHK", "length": 183 }, "evidence": [ { "id": "Q2NKY9", "url": "https://omabrowser.org/oma/group/Q2NKY9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "neutrophil differentiation", "id": "GO:0030223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030223", "evidence": [ { "database": "UniProtKB", "id": "Q2NKY9", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q2NKY9", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9" } ], "pmid": "" }, { "name": "neutrophil mediated immunity", "id": "GO:0002446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002446", "evidence": [ { "database": "UniProtKB", "id": "Q2NKY9", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "Q2NKY9", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9" } ], "pmid": "" }, { "name": "defense response to fungus", "id": "GO:0050832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050832", "evidence": [ { "database": "UniProtKB", "id": "Q2NKY9", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9" } ], "pmid": "" }, { "name": "granulocyte colony-stimulating factor signaling pathway", "id": "GO:0038158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038158", "evidence": [ { "database": "UniProtKB", "id": "Q2NKY9", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9" } ], "pmid": "" }, { "name": "endoplasmic reticulum organization", "id": "GO:0007029", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007029", "evidence": [ { "database": "UniProtKB", "id": "Q2NKY9", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9" } ], "pmid": "" }, { "name": "neutrophil migration", "id": "GO:1990266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990266", "evidence": [ { "database": "UniProtKB", "id": "Q2NKY9", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q2NKY9", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q2NKY9", "url": "https://www.uniprot.org/uniprotkb/Q2NKY9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NKY9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 183, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NKY9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NKY9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 3 ], "sequon_annotation_sites": [ { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0M0-1", "uniprot_ac": "Q3T0M0", "uniprot_id": "VPS29_BOVIN", "mass": { "chemical_mass": 20917.0, "monoisotopic_mass": 20917.0 }, "refseq": { "ac": "NP_001029627", "name": "vacuolar protein sorting-associated protein 29", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029627" }, "gene_names": [ { "name": "VPS29", "type": "recommended", "evidence": [ { "id": "Q3T0M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0" } ] }, { "name": "VPS29", "type": "synonym", "evidence": [ { "id": "NP_001029627", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029627" } ] } ], "protein_names": [ { "name": "Vacuolar protein sorting-associated protein 29", "type": "recommended", "evidence": [ { "id": "Q3T0M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0/entry#names_and_taxonomy" } ] }, { "name": "Vesicle protein sorting 29", "type": "synonym", "evidence": [ { "id": "Q3T0M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0/entry#names_and_taxonomy" } ] }, { "name": "vacuolar protein sorting 29 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029627", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029627" } ] }, { "name": "vacuolar protein sorting-associated protein 29", "type": "synonym", "evidence": [ { "id": "NP_001029627", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029627" } ] }, { "name": "vesicle protein sorting 29", "type": "synonym", "evidence": [ { "id": "NP_001029627", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029627" } ] } ], "function": [ { "annotation": "Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (By similarity). Component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (By similarity). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (By similarity). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M0", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0#function" }, { "database": "UniProtKB", "id": "Q9QZ88", "url": "https://www.uniprot.org/uniprotkb/Q9QZ88#function" }, { "database": "UniProtKB", "id": "Q9UBQ0", "url": "https://www.uniprot.org/uniprotkb/Q9UBQ0#function" }, { "database": "UniProtKB", "id": "A0ABI0P460", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P460#function" }, { "database": "UniProtKB", "id": "RU362040", "url": "https://www.uniprot.org/uniprotkb/RU362040#function" }, { "database": "UniProtKB", "id": "A0AAA9TY47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY47#function" }, { "database": "UniProtKB", "id": "G3X6P5", "url": "https://www.uniprot.org/uniprotkb/G3X6P5#function" }, { "database": "UniProtKB", "id": "A0AAF7ADH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ADH5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0M0", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VPS29", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0", "locus": { "chromosome": "17", "start_pos": 54370245, "end_pos": 54377741, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008417", "url": "https://www.ensembl.org/id/ENSBTAG00000008417" } ] } } ], "crossref": [ { "id": "Q3T0M0", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0M0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008417", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008417", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07394", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07394", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513840", "url": "https://www.ncbi.nlm.nih.gov/gene/513840", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024654", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024654", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028661", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028661", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029052", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029052", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513840", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513840", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VRGNMDY", "url": "https://omabrowser.org/oma/group/VRGNMDY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3X6P5", "url": "https://www.orthodb.org/?gene=G3X6P5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3T0M0", "url": "https://www.orthodb.org/?gene=Q3T0M0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11124", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11124", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12850", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12850", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3238698", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3238698", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029627", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TY47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY47-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ADH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ADH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ADH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ADH5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P460", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P460", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P460-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P460-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6P5", "url": "https://www.uniprot.org/uniprotkb/G3X6P5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6P5-1", "url": "https://www.uniprot.org/uniprotkb/G3X6P5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0M0", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0M0-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGHRLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKS", "length": 186, "header": "sp|Q3T0M0-1|VPS29_BOVIN Isoform 1 of Vacuolar protein sorting-associated protein 29 OS=Bos taurus OX=9913 GN=VPS29 PE=2 SV=1 CANONICAL=Q3T0M0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TY47-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0/entry#A0AAA9TY47-1", "sequence": { "sequence": "RLFYLQLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKS", "length": 187, "header": "tr|A0AAA9TY47-1|VPS29_BOVIN Computationally mapped isoform of Vacuolar protein sorting-associated protein 29 OS=Bos taurus OX=9913 GN=VPS29 PE=2 SV=1 CANONICAL=Q3T0M0-1" }, "locus": { "chromosome": "17", "start_pos": 54374692, "end_pos": 54370633, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092928.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092928.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101581.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101581.1" } ] } }, { "isoform_ac": "A0AAF7ADH5-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0/entry#A0AAF7ADH5-1", "sequence": { "sequence": "MWRCTLKGLDLAFRIAVTTCFFRRLRPFRAGHRLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKS", "length": 214, "header": "tr|A0AAF7ADH5-1|VPS29_BOVIN Computationally mapped isoform of Vacuolar protein sorting-associated protein 29 OS=Bos taurus OX=9913 GN=VPS29 PE=2 SV=1 CANONICAL=Q3T0M0-1" }, "locus": { "chromosome": "17", "start_pos": 54376824, "end_pos": 54370633, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077865.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077865.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067372.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067372.2" } ] } }, { "isoform_ac": "A0ABI0P460-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0/entry#A0ABI0P460-1", "sequence": { "sequence": "MVSTALVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKS", "length": 186, "header": "tr|A0ABI0P460-1|A0ABI0P460_BOVIN Computationally mapped isoform of Vacuolar protein sorting-associated protein 29 OS=Bos taurus OX=9913 GN=VPS29 PE=3 SV=1 CANONICAL=Q3T0M0-1" }, "locus": { "chromosome": "17", "start_pos": 54377394, "end_pos": 54370633, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000140747.1", "url": "https://www.ensembl.org/id/ENSBTAT00000140747.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106164.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106164.1" } ] } }, { "isoform_ac": "G3X6P5-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0/entry#G3X6P5-1", "sequence": { "sequence": "MGGEYLILKSYLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKS", "length": 185, "header": "tr|G3X6P5-1|VPS29_BOVIN Computationally mapped isoform of Vacuolar protein sorting-associated protein 29 OS=Bos taurus OX=9913 GN=VPS29 PE=2 SV=3 CANONICAL=Q3T0M0-1" }, "locus": { "chromosome": "17", "start_pos": 54373208, "end_pos": 54370633, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011076.6", "url": "https://www.ensembl.org/id/ENSBTAT00000011076.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011076.6", "url": "https://www.ensembl.org/id/ENSBTAP00000011076.6" } ] } }, { "isoform_ac": "Q3T0M0-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0/entry#Q3T0M0-1", "sequence": { "sequence": "MAGHRLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKS", "length": 186, "header": "sp|Q3T0M0-1|VPS29_BOVIN Isoform 1 of Vacuolar protein sorting-associated protein 29 OS=Bos taurus OX=9913 GN=VPS29 PE=2 SV=1 CANONICAL=Q3T0M0-1" }, "locus": { "chromosome": "17", "start_pos": 54377394, "end_pos": 54370633, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102320.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102320.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081267.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081267.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513840", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513840", "resource": "KEGG Pathway" }, { "id": "R-BTA-3238698", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3238698", "resource": "Reactome", "description": "WNT ligand biogenesis and trafficking" } ], "orthologs": [ { "uniprot_canonical_ac": "B2RZ78-1", "protein_name": "Vacuolar protein sorting-associated protein 29", "gene_name": "Vps29", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDESLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKS", "length": 182 }, "evidence": [ { "id": "Q3T0M0", "url": "https://omabrowser.org/oma/group/Q3T0M0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q54IF7-1", "protein_name": "Vacuolar protein sorting-associated protein 29", "gene_name": "vps29", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFIIAIGDVHVPHRSYGIPPEFKKLLVPEKIQHILCTGNLVSKEIHDYFKVLTSDVHIVRGDLDENTSYPDTKIVSIGQFKFGLCHGHQIVPWGDRASLAALQRQLDVDVLISGHTHVLEVFESNGKLFVNPGSATGAFSNISNDVIPSFVLMDVQSNNITVYIYKLIDGQVKVEKIDHVKQQ", "length": 183 }, "evidence": [ { "id": "Q3T0M0", "url": "https://omabrowser.org/oma/group/Q3T0M0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q7ZV68-1", "protein_name": "Vacuolar protein sorting-associated protein 29", "gene_name": "vps29", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLVLVLGDLHIPHRCNTLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQLDVDILISGHTHKFEAFENENKFYINPGSATGAYSALESNITPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKS", "length": 182 }, "evidence": [ { "id": "Q3T0M0", "url": "https://omabrowser.org/oma/group/Q3T0M0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9QZ88-1", "protein_name": "Vacuolar protein sorting-associated protein 29", "gene_name": "Vps29", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKS", "length": 182 }, "evidence": [ { "id": "Q3T0M0", "url": "https://omabrowser.org/oma/group/Q3T0M0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9STT2-1", "protein_name": "Vacuolar protein sorting-associated protein 29", "gene_name": "VPS29", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVLVLALGDLHVPHRAADLPPKFKSMLVPGKIQHIICTGNLCIKEIHDYLKTICPDLHIVRGEFDEDARYPENKTLTIGQFKLGLCHGHQVIPWGDLDSLAMLQRQLGVDILVTGHTHQFTAYKHEGGVVINPGSATGAYSSINQDVNPSFVLMDIDGFRAVVYVYELIDGEVKVDKIEFKKPPTTSSGP", "length": 190 }, "evidence": [ { "id": "Q3T0M0", "url": "https://omabrowser.org/oma/group/Q3T0M0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9UBQ0-1", "protein_name": "Vacuolar protein sorting-associated protein 29", "gene_name": "VPS29", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKP", "length": 182 }, "evidence": [ { "id": "Q3T0M0", "url": "https://omabrowser.org/oma/group/Q3T0M0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VPX5-1", "protein_name": "Vacuolar protein sorting-associated protein 29", "gene_name": "Vps29", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLVLVLGDLHIPHRCSSLPAKFKKLLVPGRIHHILATGNICTKESYDYLKSLANDVHIVRGDFDENLTYPEQKVVTVGQFRIGLCHGHQVVPRGDPEALALIQRQLDVDILITGHTYKFEAYEHGNKFYINPGSATGAFNPLDTNVVPSFVLMDIQSTTVVTYVYQLIGDEVKVERIEYKKI", "length": 182 }, "evidence": [ { "id": "Q3T0M0", "url": "https://omabrowser.org/oma/group/Q3T0M0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M0", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M0", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M0", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M0", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M0", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0" } ], "pmid": "" }, { "name": "retromer complex", "id": "GO:0030904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030904", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M0", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0" } ], "pmid": "" }, { "name": "retromer, cargo-selective complex", "id": "GO:0030906", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030906", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M0", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M0", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0" } ], "pmid": "" }, { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M0", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0" } ], "pmid": "" }, { "name": "endocytic recycling", "id": "GO:0032456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032456", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M0", "url": "https://www.uniprot.org/uniprotkb/Q3T0M0" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": 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"domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L97-1", "uniprot_ac": "Q32L97", "uniprot_id": "VAMP4_BOVIN", "mass": { "chemical_mass": 16393.0, "monoisotopic_mass": 16393.0 }, "refseq": { "ac": "NP_001069906", "name": "vesicle-associated membrane protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069906" }, "gene_names": [ { "name": "VAMP4", "type": "recommended", "evidence": [ { "id": "Q32L97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ] }, { "name": "VAMP4", "type": "synonym", "evidence": [ { "id": "NP_001069906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069906" } ] } ], "protein_names": [ { "name": "Vesicle-associated membrane protein 4", "type": "recommended", "evidence": [ { "id": "Q32L97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L97/entry#names_and_taxonomy" } ] }, { "name": "VAMP-4", "type": "synonym", "evidence": [ { "id": "NP_001069906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069906" }, { "id": "Q32L97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L97/entry#names_and_taxonomy" } ] }, { "name": "vesicle-associated membrane protein 4", "type": "synonym", "evidence": [ { "id": "NP_001069906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069906" } ] } ], "function": [ { "annotation": "Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z805", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z805#function" }, { "database": "UniProtKB", "id": "ARBA00057522", "url": "https://www.uniprot.org/uniprotkb/ARBA00057522#function" }, { "database": "UniProtKB", "id": "A0AAF7AHD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHD7#function" } ] }, { "annotation": "SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE) (By similarity). VAMP4 is a v-SNARE that functions in vesicle fusion with the plasma membrane. In skeletal muscle satellite cells, VAMP4 cooperates with its cognate SNAREs STX11 and SNAP23 to facilitate CD36 vesicular transport from endosomes to the plasma membrane, an essential step in muscle regeneration (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97#function" }, { "database": "UniProtKB", "id": "O75379", "url": "https://www.uniprot.org/uniprotkb/O75379#function" }, { "database": "UniProtKB", "id": "O70480", "url": "https://www.uniprot.org/uniprotkb/O70480#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VAMP4", "url": "https://www.uniprot.org/uniprotkb/Q32L97", "locus": { "chromosome": "16", "start_pos": 39145026, "end_pos": 39171438, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020591", "url": "https://www.ensembl.org/id/ENSBTAG00000020591" } ] } } ], "crossref": [ { "id": "Q32L97", "url": "https://alphafold.ebi.ac.uk/entry/Q32L97", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020591", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020591", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15869", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15869", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616923", "url": "https://www.ncbi.nlm.nih.gov/gene/616923", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042887", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042887", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616923", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616923", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NHDKASN", "url": "https://omabrowser.org/oma/group/NHDKASN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32L97", "url": "https://www.orthodb.org/?gene=Q32L97", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46897", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46897", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46897:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46897:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00957", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00957", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8856825", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8856828", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001069906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069906", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9U0V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0V8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0V8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0V8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z805", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z805", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z805-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z805-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AHD7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AHD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AHD7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L97-1", "url": "https://www.uniprot.org/uniprotkb/Q32L97-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGPRNDKIKHVQNQVDEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIMALVAVILLLVIIILIVVKYRT", "length": 141, "header": "sp|Q32L97-1|VAMP4_BOVIN Isoform 1 of Vesicle-associated membrane protein 4 OS=Bos taurus OX=9913 GN=VAMP4 PE=2 SV=1 CANONICAL=Q32L97-1" }, "isoforms": [ { "isoform_ac": "A0AAA9U0V8-1", "url": "https://www.uniprot.org/uniprotkb/Q32L97/entry#A0AAA9U0V8-1", "sequence": { "sequence": "MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGPRNDKIKHVQNQVDEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKRVFCHTTLNPSA", "length": 127, "header": "tr|A0AAA9U0V8-1|VAMP4_BOVIN Computationally mapped isoform of Vesicle-associated membrane protein 4 OS=Bos taurus OX=9913 GN=VAMP4 PE=2 SV=1 CANONICAL=Q32L97-1" }, "locus": { "chromosome": "16", "start_pos": 39168486, "end_pos": 39151099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111147.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111147.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103616.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103616.1" } ] } }, { "isoform_ac": "A0AAF6Z805-1", "url": "https://www.uniprot.org/uniprotkb/Q32L97/entry#A0AAF6Z805-1", "sequence": { "sequence": "MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGPRNDKIKHVQNQVDEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIMALVAVILLLVIISVPVLCAV", "length": 140, "header": "tr|A0AAF6Z805-1|VAMP4_BOVIN Computationally mapped isoform of Vesicle-associated membrane protein 4 OS=Bos taurus OX=9913 GN=VAMP4 PE=2 SV=1 CANONICAL=Q32L97-1" }, "locus": { "chromosome": "16", "start_pos": 39168486, "end_pos": 39147110, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027435.5", "url": "https://www.ensembl.org/id/ENSBTAT00000027435.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027435.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027435.4" } ] } }, { "isoform_ac": "A0AAF7AHD7-1", "url": "https://www.uniprot.org/uniprotkb/Q32L97/entry#A0AAF7AHD7-1", "sequence": { "sequence": "MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGPRNDKIKHVQNQVDEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIMALVAVILLLVIIRIL", "length": 135, "header": "tr|A0AAF7AHD7-1|VAMP4_BOVIN Computationally mapped isoform of Vesicle-associated membrane protein 4 OS=Bos taurus OX=9913 GN=VAMP4 PE=2 SV=1 CANONICAL=Q32L97-1" }, "locus": { "chromosome": "16", "start_pos": 39168486, "end_pos": 39147501, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071023.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071023.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069106.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069106.2" } ] } }, { "isoform_ac": "Q32L97-1", "url": "https://www.uniprot.org/uniprotkb/Q32L97/entry#Q32L97-1", "sequence": { "sequence": "MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGPRNDKIKHVQNQVDEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIMALVAVILLLVIIILIVVKYRT", "length": 141, "header": "sp|Q32L97-1|VAMP4_BOVIN Isoform 1 of Vesicle-associated membrane protein 4 OS=Bos taurus OX=9913 GN=VAMP4 PE=2 SV=1 CANONICAL=Q32L97-1" }, "locus": { "chromosome": "16", "start_pos": 39168486, "end_pos": 39146321, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094060.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094060.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102910.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102910.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 17, "end_pos": 17, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "site_lbl": "Ser17" }, { "start_pos": 30, "end_pos": 30, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "site_lbl": "Ser30" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616923", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616923", "resource": "KEGG Pathway" }, { "id": "R-BTA-6811440", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "resource": "Reactome", "description": "Retrograde transport at the Trans-Golgi-Network" }, { "id": "R-BTA-8856825", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "resource": "Reactome", "description": "Cargo recognition for clathrin-mediated endocytosis" }, { "id": "R-BTA-8856828", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "resource": "Reactome", "description": "Clathrin-mediated endocytosis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0KYT3-1", "protein_name": "Vesicle-associated membrane protein 4", "gene_name": "Vamp4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGPRNDKIKHVQNQVDEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIMALAAAILLLMIIILIVVKYRT", "length": 141 }, "evidence": [ { "id": "Q32L97", "url": "https://omabrowser.org/oma/group/Q32L97/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3GZJ6-1", "protein_name": "Vesicle-associated membrane protein 4", "gene_name": "Vamp4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGPRNDKIKHVQNQVDEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIMALAAAILLLMIIILIVVKNRT", "length": 141 }, "evidence": [ { "id": "Q32L97", "url": "https://omabrowser.org/oma/group/Q32L97/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O70480-1", "protein_name": "Vesicle-associated membrane protein 4", "gene_name": "Vamp4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGPRNDKIKHVQNQVDEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIMALAAAILLLMIIILIVVKFRT", "length": 141 }, "evidence": [ { "id": "Q32L97", "url": "https://omabrowser.org/oma/group/Q32L97/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O75379-1", "protein_name": "Vesicle-associated membrane protein 4", "gene_name": "VAMP4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGPRNDKIKHVQNQVDEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIMALVAAILLLVIIILIVMKYRT", "length": 141 }, "evidence": [ { "id": "Q32L97", "url": "https://omabrowser.org/oma/group/Q32L97/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54GB3-1", "protein_name": "Synaptobrevin-B", "gene_name": "sybB", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSNNPNNSGQPNKTQSILQEVDKVKDVMHNNIGLMLNNHDKASNLQDKTASMSNNARLFKKQTVTIRRQMWCRNMKLQLIIIAVVILVLAVILIPIIMKFV", "length": 101 }, "evidence": [ { "id": "Q32L97", "url": "https://omabrowser.org/oma/group/Q32L97/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "regulation of Golgi to plasma membrane protein transport", "id": "GO:0042996", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042996", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "pmid": "" }, { "name": "Golgi ribbon formation", "id": "GO:0090161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090161", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "pmid": "" }, { "name": "endocytic recycling", "id": "GO:0032456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032456", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "pmid": "" }, { "name": "SNARE complex assembly", "id": "GO:0035493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035493", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "pmid": "" }, { "name": "vesicle-mediated transport to the plasma membrane", "id": "GO:0098876", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098876", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 11, "go_terms": [ { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "pmid": "" }, { "name": "phagocytic vesicle", "id": "GO:0045335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045335", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "pmid": "" }, { "name": "SNARE complex", "id": "GO:0031201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031201", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "pmid": "" }, { "name": "presynaptic endosome membrane", "id": "GO:0098954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098954", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "pmid": "" }, { "name": "endocytic vesicle", "id": "GO:0030139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030139", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "pmid": "" }, { "name": "bounding membrane of organelle", "id": "GO:0098588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098588", "evidence": [ { "database": "UniProtKB", "id": "Q32L97", "url": "https://www.uniprot.org/uniprotkb/Q32L97" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" }, { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L97-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 141, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L97-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L97" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32L97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L97" }, { "id": "PRU00290", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00290" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "v-SNARE coiled-coil homology", "eco_id": "ECO_0000255", "start_pos": 52, "end_pos": 112, "start_aa": "Lys", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 17, 30 ], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 }, { "start_pos": 70, "end_pos": 72 }, { "start_pos": 94, "end_pos": 96 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ19-1", "uniprot_ac": "Q3SZ19", "uniprot_id": "PSMD9_BOVIN", "mass": { "chemical_mass": 24266.0, "monoisotopic_mass": 24266.0 }, "refseq": { "ac": "NP_001029613", "name": "26S proteasome non-ATPase regulatory subunit 9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029613" }, "gene_names": [ { "name": "PSMD9", "type": "recommended", "evidence": [ { "id": "Q3SZ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ19" } ] }, { "name": "PSMD9", "type": "synonym", "evidence": [ { "id": "NP_001029613", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029613" } ] } ], "protein_names": [ { "name": "26S proteasome non-ATPase regulatory subunit 9", "type": "recommended", "evidence": [ { "id": "Q3SZ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ19/entry#names_and_taxonomy" } ] }, { "name": "26S proteasome non-ATPase regulatory subunit 9", "type": "synonym", "evidence": [ { "id": "NP_001029613", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029613" } ] }, { "name": "26S proteasome regulatory subunit p27", "type": "synonym", "evidence": [ { "id": "NP_001029613", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029613" }, { "id": "Q3SZ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ19/entry#names_and_taxonomy" } ] }, { "name": "proteasome (prosome, macropain) 26S subunit, non-ATPase, 9", "type": "synonym", "evidence": [ { "id": "NP_001029613", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029613" } ] }, { "name": "proteasome 26S non-ATPase subunit 9", "type": "synonym", "evidence": [ { "id": "NP_001029613", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029613" } ] } ], "function": [ { "annotation": "Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ19", "url": "https://www.uniprot.org/uniprotkb/Q3SZ19#function" }, { "database": "UniProtKB", "id": "A0AAA9U2P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2P8#function" }, { "database": "UniProtKB", "id": "ARBA00054581", "url": "https://www.uniprot.org/uniprotkb/ARBA00054581#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ19", "url": "https://www.uniprot.org/uniprotkb/Q3SZ19" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSMD9", "url": "https://www.uniprot.org/uniprotkb/Q3SZ19", "locus": { "chromosome": "17", "start_pos": 53423948, "end_pos": 53438693, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004179", "url": "https://www.ensembl.org/id/ENSBTAG00000004179" } ] } } ], "crossref": [ { "id": "Q3SZ19", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ19", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004179", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004179", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513315", "url": "https://www.ncbi.nlm.nih.gov/gene/513315", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040815", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040815", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041489", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041489", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513315", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513315", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DWGGRGM", "url": "https://omabrowser.org/oma/group/DWGGRGM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ19", "url": "https://www.orthodb.org/?gene=Q3SZ19", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12651", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12651", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12651:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12651:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17820", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17820", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18265", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18265", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9907900", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9907900", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029613", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9U2P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2P8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U2P8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2P8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ19", "url": "https://www.uniprot.org/uniprotkb/Q3SZ19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ19-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ19-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEKAGSQSGGSPEASGVTVSDVQELIRRKEEIEAQIKANYEVLESQKGIGMNEPLVDCEGYPRADVDLYQVRTARHNIVCLQNDHKAVMKQVEDALHQLHARDKEKQARDLAEAHREALSRDQSQGLSPAQAFAKVNSISPGSPASIAGLQVDDEILEFGSVNTQNFQSLQNIGSVVQHSEGKPLNVTVMRRGEKHQLRLVPTRWAGKGLLGCNIIPLQR", "length": 221, "header": "sp|Q3SZ19-1|PSMD9_BOVIN Isoform 1 of 26S proteasome non-ATPase regulatory subunit 9 OS=Bos taurus OX=9913 GN=PSMD9 PE=1 SV=1 CANONICAL=Q3SZ19-1" }, "isoforms": [ { "isoform_ac": "A0AAA9U2P8-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ19/entry#A0AAA9U2P8-1", "sequence": { "sequence": "MSEKAGSQSGGSPEASGVTVSDVQELIRRKEEIEAQIKANYEVLESGLQVDDEILEFGSVNTQNFQSLQNIGSVVQHSEGKPLNVTVMRRGEKHQLRLVPTRWAGKGLLGCNIIPLQR", "length": 118, "header": "tr|A0AAA9U2P8-1|PSMD9_BOVIN Computationally mapped isoform of 26S proteasome non-ATPase regulatory subunit 9 OS=Bos taurus OX=9913 GN=PSMD9 PE=1 SV=1 CANONICAL=Q3SZ19-1" }, "locus": { "chromosome": "17", "start_pos": 53438678, "end_pos": 53424300, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101014.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101014.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103899.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103899.1" } ] } }, { "isoform_ac": "Q3SZ19-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ19/entry#Q3SZ19-1", "sequence": { "sequence": "MSEKAGSQSGGSPEASGVTVSDVQELIRRKEEIEAQIKANYEVLESQKGIGMNEPLVDCEGYPRADVDLYQVRTARHNIVCLQNDHKAVMKQVEDALHQLHARDKEKQARDLAEAHREALSRDQSQGLSPAQAFAKVNSISPGSPASIAGLQVDDEILEFGSVNTQNFQSLQNIGSVVQHSEGKPLNVTVMRRGEKHQLRLVPTRWAGKGLLGCNIIPLQR", "length": 221, "header": "sp|Q3SZ19-1|PSMD9_BOVIN Isoform 1 of 26S proteasome non-ATPase regulatory subunit 9 OS=Bos taurus OX=9913 GN=PSMD9 PE=1 SV=1 CANONICAL=Q3SZ19-1" }, "locus": { "chromosome": "17", "start_pos": 53438678, "end_pos": 53424300, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029638.4", "url": "https://www.ensembl.org/id/ENSBTAT00000029638.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029636.2", "url": "https://www.ensembl.org/id/ENSBTAP00000029636.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Identification, purification, and characterization of a PA700-dependent activator of the proteasome.", "journal": "J. Biol. Chem.", "date": "1996", "authors": "DeMartino G N, Proske R J, Moomaw C R, Strong A A, Song X, Hisamatsu H, Tanaka K, Slaughter C A", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ19", "url": "https://www.uniprot.org/uniprotkb/Q3SZ19" } ], "reference": [ { "type": "PubMed", "id": "8621709", "url": "https://glygen.org/publication/PubMed/8621709" } ] } ], "pathway": [ { "id": "bta:513315", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513315", "resource": "KEGG Pathway" }, { "id": "R-BTA-9907900", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9907900", "resource": "Reactome", "description": "Proteasome assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZLP7-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 9", "gene_name": "PSMD9", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSEQEARQSGGSPEASGVTVSDIQALIRRKEEIEAQIKANYDVLESQKGVGMNEPLVDCEGYPRSDVDLYQVRTARHNIVCLQNDHKAVMKQVEEALHQLHARDKEKQAQDLAEAHREALSLGLGQSQGLSLPQAFAKVNSISPGSPASIAGLQVDDEIVEFGSVNTQNFQSLQNIGSVVQHSEGKPLNVTVIRRGEKHQLRLVPTRWAGKGLLGCNIIPLQR", "length": 223 }, "evidence": [ { "id": "Q3SZ19", "url": "https://omabrowser.org/oma/group/Q3SZ19/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1R7L1-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 9", "gene_name": "psmd9", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKMSEENRAVVSRMTEEDVRQLIKRKDDIEEQIKAYYDMLESQAGVGMDGPLVDVEGFPRADVDLYKVRTARHSISCLQNDHKAIMVEIEEALHKLHATAKVTHEQDDTQMESSGQTVETPPPFALVDAVTHGSPAAQAGLHVGDQIMEFGSVNTQNFRNLRDIASVVQHSEGKSLRVGVFRNGQEVHLNLTPQQWSGRGLLGCNIVPLHR", "length": 211 }, "evidence": [ { "id": "Q3SZ19", "url": "https://omabrowser.org/oma/group/Q3SZ19/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3H256-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 9", "gene_name": "Psmd9", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSSEEARHRAESSEARAAAVSDIQELMRRKEEIEAQIKANYDVLESQKGIGMSEPLVDCEGYPRADVDLYQVRTARHNIICLQNDHKAVMKQVEEALHQLHARDKEKQARDMAEAQEEAMSRRLGSNSPVLPQAFAKVNSISPGSPASIAGLQVDDEIVEFGSVNTQNFQSLQNVGSVVQHSEGKPLNVTVIRRGEKHQLRLTPTRWAGKGLLGCNIIPLQR", "length": 222 }, "evidence": [ { "id": "Q3SZ19", "url": "https://omabrowser.org/oma/group/Q3SZ19/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O00233-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 9", "gene_name": "PSMD9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSDEEARQSGGSSQAGVVTVSDVQELMRRKEEIEAQIKANYDVLESQKGIGMNEPLVDCEGYPRSDVDLYQVRTARHNIICLQNDHKAVMKQVEEALHQLHARDKEKQARDMAEAHKEAMSRKLGQSESQGPPRAFAKVNSISPGSPASIAGLQVDDEIVEFGSVNTQNFQSLHNIGSVVQHSEGKPLNVTVIRRGEKHQLRLVPTRWAGKGLLGCNIIPLQR", "length": 223 }, "evidence": [ { "id": "Q3SZ19", "url": "https://omabrowser.org/oma/group/Q3SZ19/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P40555-1", "protein_name": "Probable 26S proteasome regulatory subunit p27", "gene_name": "NAS2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MEEEELSKLLANVKIDPSLTSRISQIDSFKLSELMVLKTDIETQLEAYFSVLEQQGIGMDSALVTPDGYPRSDVDVLQVTMIRKNVNMLKNDLNHLLQRSHVLLNQHFDNMNVKSNQDARRNNDDQAIQYTIPFAFISEVVPGSPSDKADIKVDDKLISIGNVHAANHSKLQNIQMVVMKNEDRPLPVLLLREGQILKTSLTPSRNWNGRGLLGCRIQEL", "length": 220 }, "evidence": [ { "id": "Q3SZ19", "url": "https://omabrowser.org/oma/group/Q3SZ19/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q552Y8-1", "protein_name": "Probable 26S proteasome non-ATPase regulatory subunit 9", "gene_name": "psmD9", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTDINNKNNNSDHSITVIEDEASIIKTLMVTRGDLEKELESLMNFLKSGDGKTFGLKGSFTDSEGYPSPHLELIIEVKKARSRIAHIQNDYKQVMKDIEFHLEKLHKSPTNKNQSSSTFSINNTTSTSNNNNNNNEDEMKIDKPLTVETETKPKPIEVEVEKVGIPFVYIDLVSEGSPSDKANLKKGDLIFQFGTVGPFFEERQVGDNLNSNHLQSIATIVRNSENKAIQIKLSRGTSIISTSLIPRKWSGQGLIGCLIKPI", "length": 262 }, "evidence": [ { "id": "Q3SZ19", "url": "https://omabrowser.org/oma/group/Q3SZ19/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9CR00-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 9", "gene_name": "Psmd9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGEDVPHRAESSEARAAAVSDIQDLMRRKEEIEAEIKANYDVLESQKGIGMNEPLVDCEGYPRADVDLYQVRTARHNIICLQNDHKALMKQVEEALHQLHARDKEKQARDMAEAREEAMNRRLASNSPVLPQAFARVNSISPGSPASIAGLQVDDEIVEFGSVNTQNFQSVQNVGTVVQHSEGKPLNVTVIRRGEKHQLRLIPTRWAGKGLLGCNIIPLQR", "length": 222 }, "evidence": [ { "id": "Q3SZ19", "url": "https://omabrowser.org/oma/group/Q3SZ19/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VFS8-1", "protein_name": "26S proteasome non-ATPase regulatory subunit 9", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAAGTTTKERLERLINAKKQLEAQINRNGQILAANDNVGMSGPLVDAEGFPRNDIDVYQVRLARQTIICLQNDHKELMNQIQTLLNQYHSEIATTDPELVNRASALDLDSDRSPGGANITDLAPARAIVVVNLVSPDSPAERAGLCAGDAILRFGSINSGNFKGDLAQIGELVRNMQSQNVQLKVKRGEQQLDLILVPKTWSGRGLLGCNIVLPPEAMDH", "length": 220 }, "evidence": [ { "id": "Q3SZ19", "url": "https://omabrowser.org/oma/group/Q3SZ19/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "proteasome regulatory particle, base subcomplex", "id": "GO:0008540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008540", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ19", "url": "https://www.uniprot.org/uniprotkb/Q3SZ19" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ19", "url": "https://www.uniprot.org/uniprotkb/Q3SZ19" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ19", "url": "https://www.uniprot.org/uniprotkb/Q3SZ19" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ19", "url": "https://www.uniprot.org/uniprotkb/Q3SZ19" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteasome regulatory particle assembly", "id": "GO:0070682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070682", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ19", "url": "https://www.uniprot.org/uniprotkb/Q3SZ19" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ19-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 221, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ19-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ19" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SZ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ19" }, { "id": "PRU00143", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00143" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000255", "start_pos": 108, "end_pos": 193, "start_aa": "Gln", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 187, "end_pos": 189 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3SX17-1", "uniprot_ac": "Q3SX17", "uniprot_id": "P2Y14_BOVIN", "mass": { "chemical_mass": 38697.0, "monoisotopic_mass": 38697.0 }, "refseq": { "ac": "NP_001070477", "name": "P2Y purinoceptor 14", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070477" }, "gene_names": [ { "name": "P2RY14", "type": "recommended", "evidence": [ { "id": "Q3SX17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX17" } ] }, { "name": "P2RY14", "type": "synonym", "evidence": [ { "id": "NP_001070477", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070477" } ] } ], "protein_names": [ { "name": "P2Y purinoceptor 14", "type": "recommended", "evidence": [ { "id": "Q3SX17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX17/entry#names_and_taxonomy" } ] }, { "name": "P2Y purinoceptor 14", "type": "synonym", "evidence": [ { "id": "NP_001070477", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070477" } ] }, { "name": "P2Y14", "type": "synonym", "evidence": [ { "id": "NP_001070477", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070477" }, { "id": "Q3SX17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX17/entry#names_and_taxonomy" } ] }, { "name": "UDP-glucose receptor", "type": "synonym", "evidence": [ { "id": "NP_001070477", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070477" }, { "id": "Q3SX17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX17/entry#names_and_taxonomy" } ] }, { "name": "purinergic receptor P2Y, G-protein coupled, 14", "type": "synonym", "evidence": [ { "id": "NP_001070477", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070477" } ] } ], "function": [ { "annotation": "Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SX17", "url": "https://www.uniprot.org/uniprotkb/Q3SX17#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SX17", "url": "https://www.uniprot.org/uniprotkb/Q3SX17" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "P2RY14", "url": "https://www.uniprot.org/uniprotkb/Q3SX17", "locus": { "chromosome": "1", "start_pos": 116880422, "end_pos": 116813704, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020990", "url": "https://www.ensembl.org/id/ENSBTAG00000020990" } ] } } ], "crossref": [ { "id": "Q3SX17", "url": "https://alphafold.ebi.ac.uk/entry/Q3SX17", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020990", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020990", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15149", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15149", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "767936", "url": "https://www.ncbi.nlm.nih.gov/gene/767936", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767936", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767936", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FVHTVNY", "url": "https://omabrowser.org/oma/group/FVHTVNY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SX17", "url": "https://www.orthodb.org/?gene=Q3SX17", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24233", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24233", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24233:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24233:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-417957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-417957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001070477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070477", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6Z8E4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8E4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z8E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8E4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SX17", "url": "https://www.uniprot.org/uniprotkb/Q3SX17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SX17-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX17-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNATSVPPAEGSCPSNALITKQIIPMLYFVVFVAGILLNGMSGWVFFYVPSSKSFIVYLKNIVIADFLMSLTFPFKILGDLGLGLWQVKVFVCRVSAVLFYINMYVSIVFFGLIGFDRYYKIVKPLLTSFIQSISYSKLLSVLVWSLTLLIALPNMILTNRNVTEATRVKCMDLKSDLGLKWHKASSYIFVGIFWIVFLSLIIFYTAITKKIFKSHFKSRKNSVSVKKKSSRNIFSIMFVFFICFVPYHIARIPYTQSQTEAHYSCQSKQILFYVKEFSLLLSAANVCLDPIIYFFLCQPFREVLCKKLHIQLKTQHDSETSKIKRENIIQESTDTL", "length": 337, "header": "sp|Q3SX17-1|P2Y14_BOVIN Isoform 1 of P2Y purinoceptor 14 OS=Bos taurus OX=9913 GN=P2RY14 PE=2 SV=1 CANONICAL=Q3SX17-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z8E4-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX17/entry#A0AAF6Z8E4-1", "sequence": { "sequence": "MGNKQHKIQDRVLSQWRKAQPRGNEKGKVGIPGHTFRSYQTMNATSVPPAEGSCPSNALITKQIIPMLYFVVFVAGILLNGMSGWVFFYVPSSKSFIVYLKNIVIADFLMSLTFPFKILGDLGLGLWQVKVFVCRVSAVLFYINMYVSIVFFGLIGFDRYYKIVKPLLTSFIQSISYSKLLSVLVWSLTLLIALPNMILTNRNVTEATRVKCMDLKSDLGLKWHKASSYIFVGIFWIVFLSLIIFYTAITKKIFKSHFKSRKNSVSVKKKSSRNIFSIMFVFFICFVPYHIARIPYTQSQTEAHYSCQSKQILFYVKEFSLLLSAANVCLDPIIYFFLCQPFREVLCKKLHIQLKTQHDSETSKIKRENIIQESTDTL", "length": 378, "header": "tr|A0AAF6Z8E4-1|P2Y14_BOVIN Computationally mapped isoform of P2Y purinoceptor 14 OS=Bos taurus OX=9913 GN=P2RY14 PE=2 SV=1 CANONICAL=Q3SX17-1" }, "locus": { "chromosome": "1", "start_pos": 116879085, "end_pos": 116861309, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027950.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027950.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027950.5", "url": "https://www.ensembl.org/id/ENSBTAP00000027950.5" } ] } }, { "isoform_ac": "Q3SX17-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX17/entry#Q3SX17-1", "sequence": { "sequence": "MNATSVPPAEGSCPSNALITKQIIPMLYFVVFVAGILLNGMSGWVFFYVPSSKSFIVYLKNIVIADFLMSLTFPFKILGDLGLGLWQVKVFVCRVSAVLFYINMYVSIVFFGLIGFDRYYKIVKPLLTSFIQSISYSKLLSVLVWSLTLLIALPNMILTNRNVTEATRVKCMDLKSDLGLKWHKASSYIFVGIFWIVFLSLIIFYTAITKKIFKSHFKSRKNSVSVKKKSSRNIFSIMFVFFICFVPYHIARIPYTQSQTEAHYSCQSKQILFYVKEFSLLLSAANVCLDPIIYFFLCQPFREVLCKKLHIQLKTQHDSETSKIKRENIIQESTDTL", "length": 337, "header": "sp|Q3SX17-1|P2Y14_BOVIN Isoform 1 of P2Y purinoceptor 14 OS=Bos taurus OX=9913 GN=P2RY14 PE=2 SV=1 CANONICAL=Q3SX17-1" }, "locus": { "chromosome": "1", "start_pos": 116879085, "end_pos": 116878075, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115613.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115613.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087097.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087097.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 162, "start_aa": "Asn", "end_pos": 162, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn162", "evidence": [ { "id": "Q3SX17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX17#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 2, "start_aa": "Asn", "end_pos": 2, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn2", "evidence": [ { "id": "Q3SX17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX17#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q3SX17", "url": "https://www.uniprot.org/uniprotkb/Q3SX17" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:767936", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767936", "resource": "KEGG Pathway" }, { "id": "R-BTA-417957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-417957", "resource": "Reactome", "description": "P2Y receptors" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2KD19-1", "protein_name": "P2Y purinoceptor 14", "gene_name": "LOC793750", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDNSTQPANVTKVSSVFTNEVLPVLYTIICVCALILNGLAAWIFFRLPSSSALVVYLKNMVVADVLMLFSYPWRVVGDLGYGGFQLKLIVCRYTAVLFYLSMYTGIAFMSLISLERYFKIVCSSSRVSSFLQRVWVAKALALLAWGIMIFFSLPNTILSNQPMPKVFSCMALKSELGRNWHVVSAHFNVGIFWVAFLLMVFCYTSIACHVYRSYKRVQRDSSAAGRRSNQSIFSLLAVFIICFVPYHVCRVPYTMSQRSNSGYQPQDRYVLFQIKEATLFLSALNVCLDPVIYFFMCRIFRESLL", "length": 305 }, "evidence": [ { "id": "Q3SX17", "url": "https://omabrowser.org/oma/group/Q3SX17/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0X6Q7-1", "protein_name": "Purinergic receptor P2Y, G-protein coupled, 14", "gene_name": "P2RY14", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MFNSSTNSSGSSCSNSTVITRAVIPLIYCLIFVVGLLLNGVAAWIFLCISSKKSFIVYLKNIVVADLLMSLTFPFKILADSEIAPPQLNTFVCRYSAVVFYANMYIGISFFGLIGFDRYYKIVKPLFTSFVHTVHYSKVISAIIWLLITFITLPNMILTNEISKANDSRTCIGLKSELGKQWHEVSSYICTGIFWIVFLLLIIFYTSISKKIYSSYKKFRRNSDSAKRKTSRNIFTIMFVFVLCFVPYHFCRIPYTLSQTSPQFNCRSQRALFLAKEFTLLLSAANVCLDPIIYFFLCQPFRERLYQKLHLQPKTSGEAEITKSRRSNTLQESVNIL", "length": 337 }, "evidence": [ { "id": "Q3SX17", "url": "https://omabrowser.org/oma/group/Q3SX17/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SJN3-1", "protein_name": "Purinergic receptor P2Y14", "gene_name": "P2RY14", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMNATTTQAPEESCPQNTLITQKIIPALYFVVFVAGILLNGVSGWIFFYVPSSKSFIVYLKNIVVADFLMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYINMYVSIVFFGFIGFDRYYKIVKPLLTSFVQSVTSSKLLSVLVWSLTLLLAVPNMILTNQSVREGTRIKCVELKNELGRNWHKASNYIFVGIFWIVFLSLIIFYTAITRKIFKSHLKARKNSSSVKKKSSRNIFSIMFVFFVCFVPYHIARIPYTRSQTEAHYSCQSKEILLYVKEFALLLSAANVCLDPIIYFFLCQPFREILCKKLHIPVKARHDLETSKTKRGNIMQESTDTL", "length": 338 }, "evidence": [ { "id": "Q3SX17", "url": "https://omabrowser.org/oma/group/Q3SX17/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HG48-1", "protein_name": "P2Y purinoceptor 14", "gene_name": "P2ry14", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVNSTTTEPPNQPCSRNTLITQQIIPVLYCVVFITGILLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLGDSGLGPWQVNVFVCRVSAVIFYVNMYVSIVFFGLISFDRYYKIVKPLLTSVVQSVNYSKLLSVVVWMLMLLLAVPNIILTNQSVKEITKIQCMELKNELGRKWHKASNYAFVSIFWIVFLLLIIFYTAITRKIFKSHLKSRRNSISVKRKSSRNIFSIVLVFFVCFVPYHIARIPYTKSQMESHYSCQSKETLLYVKEFTLLLSAANVCLDPIIYFFLCQPFREVLNKKLHISLKGQNDLDTSKSKRGNTVHESTDTL", "length": 338 }, "evidence": [ { "id": "Q3SX17", "url": "https://omabrowser.org/oma/group/Q3SX17/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O35881-1", "protein_name": "P2Y purinoceptor 14", "gene_name": "P2ry14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDNTTTTEPPKQPCTRNTLITQQIIPMLYCVVFITGVLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLSDSGLGPWQLNVFVFRVSAVIFYVNMYVSIAFFGLISFDRYYKIVKPLLVSIVQSVNYSKVLSVLVWVLMLLLAVPNIILTNQSVKDVTNIQCMELKNELGRKWHKASNYVFVSIFWIVFLLLTVFYMAITRKIFKSHLKSRKNSISVKRKSSRNIFSIVLAFVACFAPYHVARIPYTKSQTEGHYSCQAKETLLYTKEFTLLLSAANVCLDPISISSYASRLEKS", "length": 305 }, "evidence": [ { "id": "Q3SX17", "url": "https://omabrowser.org/oma/group/Q3SX17/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q15391-1", "protein_name": "P2Y purinoceptor 14", "gene_name": "P2RY14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL", "length": 338 }, "evidence": [ { "id": "Q3SX17", "url": "https://omabrowser.org/oma/group/Q3SX17/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3SX17", "url": "https://www.uniprot.org/uniprotkb/Q3SX17" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "Q3SX17", "url": "https://www.uniprot.org/uniprotkb/Q3SX17" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "G protein-coupled purinergic nucleotide receptor activity", "id": "GO:0045028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045028", "evidence": [ { "database": "UniProtKB", "id": "Q3SX17", "url": "https://www.uniprot.org/uniprotkb/Q3SX17" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SX17-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 337, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SX17-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SX17" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 2, 162 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 162, "end_pos": 164 }, { "start_pos": 2, "end_pos": 4 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3MHV9-1", "uniprot_ac": "Q3MHV9", "uniprot_id": "SERC1_BOVIN", "mass": { "chemical_mass": 50628.0, "monoisotopic_mass": 50628.0 }, "refseq": { "ac": "NP_001030504", "name": "serine incorporator 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030504" }, "gene_names": [ { "name": "SERINC1", "type": "recommended", "evidence": [ { "id": "Q3MHV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHV9" } ] }, { "name": "SERINC1", "type": "synonym", "evidence": [ { "id": "NP_001030504", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030504" } ] }, { "name": "SERINC2", "type": "synonym", "evidence": [ { "id": "NP_001030504", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030504" } ] }, { "name": "TDE2", "type": "synonym", "evidence": [ { "id": "Q3MHV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHV9" } ] } ], "protein_names": [ { "name": "Serine incorporator 1", "type": "recommended", "evidence": [ { "id": "Q3MHV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHV9/entry#names_and_taxonomy" } ] }, { "name": "Tumor differentially expressed protein 2", "type": "synonym", "evidence": [ { "id": "Q3MHV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHV9/entry#names_and_taxonomy" } ] }, { "name": "serine incorporator 1", "type": "synonym", "evidence": [ { "id": "NP_001030504", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030504" } ] }, { "name": "serine incorporator 2", "type": "synonym", "evidence": [ { "id": "NP_001030504", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030504" } ] }, { "name": "tumor differentially expressed 2", "type": "synonym", "evidence": [ { "id": "NP_001030504", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030504" } ] }, { "name": "tumor differentially expressed protein 2", "type": "synonym", "evidence": [ { "id": "NP_001030504", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030504" } ] } ], "function": [ { "annotation": "Enhances the incorporation of serine into phosphatidylserine and sphingolipids.", "evidence": [ { "database": "UniProtKB", "id": "F1MBF9", "url": "https://www.uniprot.org/uniprotkb/F1MBF9#function" }, { "database": "UniProtKB", "id": "ARBA00037552", "url": "https://www.uniprot.org/uniprotkb/ARBA00037552#function" }, { "database": "UniProtKB", "id": "Q3MHV9", "url": "https://www.uniprot.org/uniprotkb/Q3MHV9#function" }, { "database": "UniProtKB", "id": "Q7TNK0", "url": "https://www.uniprot.org/uniprotkb/Q7TNK0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHV9", "url": "https://www.uniprot.org/uniprotkb/Q3MHV9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SERINC1", "url": "https://www.uniprot.org/uniprotkb/Q3MHV9", "locus": { "chromosome": "9", "start_pos": 28756270, "end_pos": 28722620, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000019", "url": "https://www.ensembl.org/id/ENSBTAG00000000019" } ] } } ], "crossref": [ { "id": "Q3MHV9", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHV9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000019", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000019", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539993", "url": "https://www.ncbi.nlm.nih.gov/gene/539993", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005016", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005016", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539993", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539993", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MBF9", "url": "https://www.orthodb.org/?gene=F1MBF9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3MHV9", "url": "https://www.orthodb.org/?gene=Q3MHV9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10383", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10383", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10383:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10383:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03348", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03348", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-977347", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977347", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030504", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MBF9", "url": "https://www.uniprot.org/uniprotkb/F1MBF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBF9-1", "url": "https://www.uniprot.org/uniprotkb/F1MBF9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHV9", "url": "https://www.uniprot.org/uniprotkb/Q3MHV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHV9-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHV9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSVLGLCSMASWIPCLCGSAPCLLCRCCPSGNNSTVTRLIYALFLLVGVCVACVMLIPGMEEQLNKIPGFCENEKGMVPCNILVGYKAVYRLCFGLAMFYLLLSLLMIKVKSSSDPRAAIHNGFWFFKFAAAIAIIIGAFFIPEGTFTTVWFYVGMAGAFCFILIQLVLLIDFAHSWNESWVEKMEEGNSRCWYAALLSATALNYLLSLVAVVLFFVYYTHPASCAENKAFISVNMLLCLGASIMSILPKIQESQPRSGLLQSSVITVYTMYLTWSAMTNEPETECNPSLLNIIGYNTTSTVSKEGQSVQWWHTQGIIGLILFLLCVFYSSIRTSNNSQVNKLTLTSDESTLIEDGGARNDGSLEDGDDVHRAVDNERDGVTYSYSFFHFMLFLASLYIMMTLTNWYRYEPSREMKSQWTAVWVKISSSWIGIVLYVWTLVAPLVLTNRDFD", "length": 453, "header": "sp|Q3MHV9-1|SERC1_BOVIN Isoform 1 of Serine incorporator 1 OS=Bos taurus OX=9913 GN=SERINC1 PE=2 SV=1 CANONICAL=Q3MHV9-1" }, "isoforms": [ { "isoform_ac": "F1MBF9-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHV9/entry#F1MBF9-1", "sequence": { "sequence": "LNSTTGIPCLCGSAPCLLCRCCPSGNNSTVTRLIYALFLLVGVCVACVMLIPGMEEQLNKIPGFCENEKGMVPCNILVGYKAVYRLCFGLAMFYLLLSLLMIKVKSSSDPRAAIHNGFWFFKFAAAIAIIIGAFFIPEGTFTTVWFYVGMAGAFCFILIQLVLLIDFAHSWNESWVEKMEEGNSRCWYAALLSATALNYLLSLVAVVLFFVYYTHPASCAENKAFISVNMLLCLGASIMSILPKIQESQPRSGLLQSSVITVYTMYLTWSAMTNEPETECNPSLLNIIGYNTTSTVSKEGQSVQWWHTQGIIGLILFLLCVFYSSIRTSNNSQVNKLTLTSDESTLIEDGGARNDGSLEDGDDVHRAVDNERDGVTYSYSFFHFMLFLASLYIMMTLTNWYRYEPSREMKSQWTAVWVKISSSWIGIVLYVWTLVAPLVLTNRDFD", "length": 446, "header": "tr|F1MBF9-1|SERC1_BOVIN Computationally mapped isoform of Serine incorporator 1 OS=Bos taurus OX=9913 GN=SERINC1 PE=2 SV=4 CANONICAL=Q3MHV9-1" }, "locus": { "chromosome": "9", "start_pos": 28754851, "end_pos": 28739624, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000021.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000021.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000021.7", "url": "https://www.ensembl.org/id/ENSBTAP00000000021.7" } ] } }, { "isoform_ac": "Q3MHV9-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHV9/entry#Q3MHV9-1", "sequence": { "sequence": "MGSVLGLCSMASWIPCLCGSAPCLLCRCCPSGNNSTVTRLIYALFLLVGVCVACVMLIPGMEEQLNKIPGFCENEKGMVPCNILVGYKAVYRLCFGLAMFYLLLSLLMIKVKSSSDPRAAIHNGFWFFKFAAAIAIIIGAFFIPEGTFTTVWFYVGMAGAFCFILIQLVLLIDFAHSWNESWVEKMEEGNSRCWYAALLSATALNYLLSLVAVVLFFVYYTHPASCAENKAFISVNMLLCLGASIMSILPKIQESQPRSGLLQSSVITVYTMYLTWSAMTNEPETECNPSLLNIIGYNTTSTVSKEGQSVQWWHTQGIIGLILFLLCVFYSSIRTSNNSQVNKLTLTSDESTLIEDGGARNDGSLEDGDDVHRAVDNERDGVTYSYSFFHFMLFLASLYIMMTLTNWYRYEPSREMKSQWTAVWVKISSSWIGIVLYVWTLVAPLVLTNRDFD", "length": 453, "header": "sp|Q3MHV9-1|SERC1_BOVIN Isoform 1 of Serine incorporator 1 OS=Bos taurus OX=9913 GN=SERINC1 PE=2 SV=1 CANONICAL=Q3MHV9-1" }, "locus": { "chromosome": "9", "start_pos": 28754851, "end_pos": 28722653, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087235.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087235.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065597.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065597.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 351, "end_pos": 351, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV9", "url": "https://www.uniprot.org/uniprotkb/Q3MHV9" } ], "site_lbl": "Ser351" }, { "start_pos": 352, "end_pos": 352, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV9", "url": "https://www.uniprot.org/uniprotkb/Q3MHV9" } ], "site_lbl": "Thr352" }, { "start_pos": 364, "end_pos": 364, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV9", "url": "https://www.uniprot.org/uniprotkb/Q3MHV9" } ], "site_lbl": "Ser364" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539993", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539993", "resource": "KEGG Pathway" }, { "id": "R-BTA-977347", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977347", "resource": "Reactome", "description": "Serine metabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV9", "url": "https://www.uniprot.org/uniprotkb/Q3MHV9" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV9", "url": "https://www.uniprot.org/uniprotkb/Q3MHV9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "phospholipid biosynthetic process", "id": "GO:0008654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008654", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV9", "url": "https://www.uniprot.org/uniprotkb/Q3MHV9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" }, { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" }, { "start_pos": 337, "end_pos": 339, "annotation": "n_glycosylation_sequon" }, { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHV9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 453, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHV9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHV9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 351, 352, 364 ], "sequon_annotation_sites": [ { "start_pos": 179, "end_pos": 181 }, { "start_pos": 298, "end_pos": 300 }, { "start_pos": 337, "end_pos": 339 }, { "start_pos": 33, "end_pos": 35 }, { "start_pos": 34, "end_pos": 36 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZA5-1", "uniprot_ac": "Q3SZA5", "uniprot_id": "SPSY_BOVIN", "mass": { "chemical_mass": 41224.0, "monoisotopic_mass": 41224.0 }, "refseq": { "ac": "NP_001030548", "name": "spermine synthase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030548" }, "gene_names": [ { "name": "SMS", "type": "recommended", "evidence": [ { "id": "Q3SZA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5" } ] }, { "name": "SMS", "type": "synonym", "evidence": [ { "id": "NP_001030548", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030548" } ] } ], "protein_names": [ { "name": "Spermine synthase", "type": "recommended", "evidence": [ { "id": "Q3SZA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5/entry#names_and_taxonomy" } ] }, { "name": "2.5.1.22", "type": "synonym", "evidence": [ { "id": "Q3SZA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5/entry#names_and_taxonomy" } ] }, { "name": "SPMSY", "type": "synonym", "evidence": [ { "id": "NP_001030548", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030548" }, { "id": "Q3SZA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5/entry#names_and_taxonomy" } ] }, { "name": "Spermidine aminopropyltransferase", "type": "synonym", "evidence": [ { "id": "Q3SZA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5/entry#names_and_taxonomy" } ] }, { "name": "spermidine aminopropyltransferase", "type": "synonym", "evidence": [ { "id": "NP_001030548", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030548" } ] }, { "name": "spermine synthase", "type": "synonym", "evidence": [ { "id": "NP_001030548", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030548" } ] } ], "function": [ { "annotation": "Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA5", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5#function" }, { "database": "UniProtKB", "id": "P52788", "url": "https://www.uniprot.org/uniprotkb/P52788#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZA5", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMS", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5", "locus": { "chromosome": "X", "start_pos": 121317046, "end_pos": 121367225, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018382", "url": "https://www.ensembl.org/id/ENSBTAG00000018382" } ] } } ], "crossref": [ { "id": "Q3SZA5", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZA5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018382", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018382", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615950", "url": "https://www.ncbi.nlm.nih.gov/gene/615950", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR015576", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015576", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030373", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030373", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030374", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030374", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035246", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035246", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037163", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040900", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040900", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615950", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615950", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PDGKEPI", "url": "https://omabrowser.org/oma/group/PDGKEPI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1ME02", "url": "https://www.orthodb.org/?gene=F1ME02", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3SZA5", "url": "https://www.orthodb.org/?gene=Q3SZA5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46315", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46315", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46315:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46315:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01564", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01564", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17284", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17284", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17950", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17950", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-351202", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-351202", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030548", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19973", "url": "https://www.rhea-db.org/rhea/19973", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1ME02", "url": "https://www.uniprot.org/uniprotkb/F1ME02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ME02-1", "url": "https://www.uniprot.org/uniprotkb/F1ME02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZA5", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZA5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAARHSTLDFMLGAKADGETILKGLQSIFQEQGMTESVHTWQDHGYLATYINKNGSFANLRIYPHGLVLLDLQSYDGDAQGKEVDSLLNKVEERMKELSQDSTERVKRLPPIVRGGAIDRYWPTADGRLVEYDIDKVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRAIMGSGKEDYSGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRKTCGDVLDNLKGDCYQVLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTVWKKAKP", "length": 365, "header": "sp|Q3SZA5-1|SPSY_BOVIN Isoform 1 of Spermine synthase OS=Bos taurus OX=9913 GN=SMS PE=2 SV=1 CANONICAL=Q3SZA5-1" }, "isoforms": [ { "isoform_ac": "F1ME02-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5/entry#F1ME02-1", "sequence": { "sequence": "MPIALFRVSQKFIHQTVLSDGETILKGLQSIFQEQGMTESVHTWQDHGYLATYINKNGSFANLRIYPHGLVLLDLQSYDGDAQGKEVDSLLNKVEERMKELSQDSTERVKRLPPIVRGGAIDRYWPTADGRLVEYDIDKVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRAIMGSGKEDYSGKDVLILGGGDGGILCEIVKLKPKMVTMVEISFAKYMRKTCGDVLDNLKGDCYQVLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELYPLTTSSCCPIRTPM", "length": 364, "header": "tr|F1ME02-1|SPSY_BOVIN Computationally mapped isoform of Spermine synthase OS=Bos taurus OX=9913 GN=SMS PE=2 SV=4 CANONICAL=Q3SZA5-1" }, "locus": { "chromosome": "X", "start_pos": 121347510, "end_pos": 121318771, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024458.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024458.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024458.7", "url": "https://www.ensembl.org/id/ENSBTAP00000024458.7" } ] } }, { "isoform_ac": "Q3SZA5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5/entry#Q3SZA5-1", "sequence": { "sequence": "MAAARHSTLDFMLGAKADGETILKGLQSIFQEQGMTESVHTWQDHGYLATYINKNGSFANLRIYPHGLVLLDLQSYDGDAQGKEVDSLLNKVEERMKELSQDSTERVKRLPPIVRGGAIDRYWPTADGRLVEYDIDKVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRAIMGSGKEDYSGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRKTCGDVLDNLKGDCYQVLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTVWKKAKP", "length": 365, "header": "sp|Q3SZA5-1|SPSY_BOVIN Isoform 1 of Spermine synthase OS=Bos taurus OX=9913 GN=SMS PE=2 SV=1 CANONICAL=Q3SZA5-1" }, "locus": { "chromosome": "X", "start_pos": 121367115, "end_pos": 121317514, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081528.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081528.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071420.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071420.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 57, "end_pos": 57, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA5", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5" } ], "site_lbl": "Ser57" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA5", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:615950", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615950", "resource": "KEGG Pathway" }, { "id": "R-BTA-351202", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-351202", "resource": "Reactome", "description": "Metabolism of polyamines" } ], "orthologs": [ { "uniprot_canonical_ac": "F1NBG8-1", "protein_name": "Spermine synthase", "gene_name": "SMS", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAARHSTLDFMLGATADCNAVLKALQPVFQEQGMTETVHNWEDHGYLATYIKKNGSFANLRIHPHGLVLVDLQSYNDHTKGREETDQLLNKVEERMKELFHGNLKRIKRLPAILRGGVIDRYWPTADGRLVEYDIDEVVYDEDSPFQNIKILHSKQFGNILILSGDVNLAESDLAYTRAIMGSGKEDYTGKEVLILGGGDGGILYEIVKLKPKMVTMVEIDQMVIDGCKKYMRKTCGDVLDNLKGECYQVLIEDCIPVLKRYAKEGRMFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFTQGNCINLTDALTLYEEQLSRLYCPVEFSKEIVCVPSYMELWVFYTIWKKQTEV", "length": 367 }, "evidence": [ { "id": "Q3SZA5", "url": "https://omabrowser.org/oma/group/Q3SZA5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P52788-1", "protein_name": "Spermine synthase", "gene_name": "SMS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAARHSTLDFMLGAKADGETILKGLQSIFQEQGMAESVHTWQDHGYLATYTNKNGSFANLRIYPHGLVLLDLQSYDGDAQGKEEIDSILNKVEERMKELSQDSTGRVKRLPPIVRGGAIDRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRAIMGSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRKTCGDVLDNLKGDCYQVLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTVWKKAKP", "length": 366 }, "evidence": [ { "id": "Q3SZA5", "url": "https://omabrowser.org/oma/group/Q3SZA5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P97355-1", "protein_name": "Spermine synthase", "gene_name": "Sms", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAARHSTLDFKLGAKADGEAILKGLQSIFQEQGMTESVHTWQDHGYLATYTNKNGSFANLRIYPHGLVLLDLQSYDSDVQGKQETDSLLNKIEEKMKELSQDSTGRVKRLPPIVRGGAIDRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRAIMGSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRRTCGDVLDNLRGDCYQVLIEDCIPVLKMYAKEGREFDYVINDLTAVPISTSPEEDSTWDFLRLILDLSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTVWKKAKP", "length": 366 }, "evidence": [ { "id": "Q3SZA5", "url": "https://omabrowser.org/oma/group/Q3SZA5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA5", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "spermine biosynthetic process", "id": "GO:0006597", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006597", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA5", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "spermine synthase activity", "id": "GO:0016768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016768", "evidence": [ { "database": "UniProtKB", "id": "Q3SZA5", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 319, "end_pos": 321, "annotation": "n_glycosylation_sequon" }, { "start_pos": 55, "end_pos": 57, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19973", "name": "", "equation": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = spermine + S-methyl-5'-thioadenosine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3SZA5-1" ], "evidence": [ { "id": "19973", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19973" } ] }, { "id": "R-BTA-351210", "name": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-353113" ], "output_participant_list": [ "R-ALL-353560" ], "enzyme_list": [ "Q3SZA5-1" ], "evidence": [ { "id": "R-BTA-351210", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-351210" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-353113", "participant_name": "dc-AdoMet [cytosol]", "crossref": [ { "id": "57443", "database": "ChEBI", "url": "" }, { "id": "5121", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "ZINC000004095557", "database": "ZINC", "url": "" }, { "id": "ZINC000004095558", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-353560", "participant_name": "SPN [cytosol]", "crossref": [ { "id": "45725", "database": "ChEBI", "url": "" }, { "id": "C00750", "database": "COMPOUND", "url": "" }, { "id": "ZINC000001532734", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q3SZA5", "gene_name": "SMS", "activity": [ { "ec_number": "2.5.1.22", "activity": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = spermine + S-methyl-5'-thioadenosine + H(+).", "evidence": [ { "id": "Q3SZA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5" } ] }, { "ec_number": "2.5.1.22", "activity": "", "evidence": [ { "id": "Q3SZA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZA5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 365, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZA5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZA5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SZA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZA5" }, { "id": "PRU00354", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00354" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PABS", "eco_id": "ECO_0000255", "start_pos": 121, "end_pos": 361, "start_aa": "Arg", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.5.1.22", "ec_name": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = spermine + S-methyl-5'-thioadenosine + H(+).", "evidence": [ { "id": "2.5.1.22", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.22" }, { "id": "2.5.1.22", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.5.1.22" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 57 ], "sequon_annotation_sites": [ { "start_pos": 319, "end_pos": 321 }, { "start_pos": 55, "end_pos": 57 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3MHV6-1", "uniprot_ac": "Q3MHV6", "uniprot_id": "SLAI2_BOVIN", "mass": { "chemical_mass": 62770.0, "monoisotopic_mass": 62770.0 }, "refseq": { "ac": "NP_001030482", "name": "SLAIN motif-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030482" }, "gene_names": [ { "name": "SLAIN2", "type": "recommended", "evidence": [ { "id": "Q3MHV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ] }, { "name": "SLAIN2", "type": "synonym", "evidence": [ { "id": "NP_001030482", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030482" } ] } ], "protein_names": [ { "name": "SLAIN motif-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q3MHV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6/entry#names_and_taxonomy" } ] }, { "name": "SLAIN motif-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001030482", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030482" } ] } ], "function": [ { "annotation": "Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLAIN2", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6", "locus": { "chromosome": "6", "start_pos": 67117951, "end_pos": 67048701, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021963", "url": "https://www.ensembl.org/id/ENSBTAG00000021963" } ] } } ], "crossref": [ { "id": "Q3MHV6", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHV6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021963", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021963", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534203", "url": "https://www.ncbi.nlm.nih.gov/gene/534203", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534203", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534203", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "XSLPAPK", "url": "https://omabrowser.org/oma/group/XSLPAPK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MF02", "url": "https://www.orthodb.org/?gene=F1MF02", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3MHV6", "url": "https://www.orthodb.org/?gene=Q3MHV6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22406", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22406", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22406:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22406:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15301", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15301", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030482", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MF02", "url": "https://www.uniprot.org/uniprotkb/F1MF02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF02-1", "url": "https://www.uniprot.org/uniprotkb/F1MF02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHV6-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDVNSDVNADQEVRKLQELVKMLEKQNEQLRSRSGAVQGAGSFGPGSPVRAGASTPSSGTASPRGFPLGLSAKSGSGAGSGPRRTSSEELRDATSLLAAGEGGLLDEVEPLRPEELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPSPDVECAKKSLIHKLDQTMSALKRQNLYNNPFNSVSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAATASRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRVSPQPMISRLQQPRLSLQGHPTDLQTTNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASAIPSPGKFRSPAAPSPLALRQPVKAFSNHGSGSPGSQETTQLMQTTSSPGPPMVQNTVPANPPSNINSTTLTRPAGTTVMRSGLPRPSAPSAGGIPVPRSKLAQPVRRSLPAPKTYGSMKDDSWKDGCY", "length": 582, "header": "sp|Q3MHV6-1|SLAI2_BOVIN Isoform 1 of SLAIN motif-containing protein 2 OS=Bos taurus OX=9913 GN=SLAIN2 PE=2 SV=1 CANONICAL=Q3MHV6-1" }, "isoforms": [ { "isoform_ac": "F1MF02-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6/entry#F1MF02-1", "sequence": { "sequence": "MEDVNSDVNADQEVRKLQELVKMLEKQNEQLRSRSGAVQGAGSFGPGSPVRAGASTPSSGTASPRGFPLGLSAKSGSGAGSGPRRTSSEELRDATSLLAAGEGGLLDEVEPLRPEELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPSPDVECAKKSLIHKLDQTMSALKRQNLYNNPFNSVSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAATASRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRVSPQPMISRLQQPRLSLQGHPTDLQTTNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASATSQRLKNLPRTSLKAKQLLQTSSTKRVPSPGKFRSPAAPSPLALRQPVKAFSNHGSGSPGSQETTQLMQTTSSPGPPMVQNTVPANPPSNINSTTLTRPAGTTVMRSGLPRPSAPSAGGIPVPRSKLAQPVRRSLPAPKTYGSMKDDSWKDGCY", "length": 608, "header": "tr|F1MF02-1|SLAI2_BOVIN Computationally mapped isoform of SLAIN motif-containing protein 2 OS=Bos taurus OX=9913 GN=SLAIN2 PE=2 SV=2 CANONICAL=Q3MHV6-1" }, "locus": { "chromosome": "6", "start_pos": 67117506, "end_pos": 67048897, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029282.7", "url": "https://www.ensembl.org/id/ENSBTAT00000029282.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029282.5", "url": "https://www.ensembl.org/id/ENSBTAP00000029282.5" } ] } }, { "isoform_ac": "Q3MHV6-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6/entry#Q3MHV6-1", "sequence": { "sequence": "MEDVNSDVNADQEVRKLQELVKMLEKQNEQLRSRSGAVQGAGSFGPGSPVRAGASTPSSGTASPRGFPLGLSAKSGSGAGSGPRRTSSEELRDATSLLAAGEGGLLDEVEPLRPEELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPSPDVECAKKSLIHKLDQTMSALKRQNLYNNPFNSVSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAATASRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRVSPQPMISRLQQPRLSLQGHPTDLQTTNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASAIPSPGKFRSPAAPSPLALRQPVKAFSNHGSGSPGSQETTQLMQTTSSPGPPMVQNTVPANPPSNINSTTLTRPAGTTVMRSGLPRPSAPSAGGIPVPRSKLAQPVRRSLPAPKTYGSMKDDSWKDGCY", "length": 582, "header": "sp|Q3MHV6-1|SLAI2_BOVIN Isoform 1 of SLAIN motif-containing protein 2 OS=Bos taurus OX=9913 GN=SLAIN2 PE=2 SV=1 CANONICAL=Q3MHV6-1" }, "locus": { "chromosome": "6", "start_pos": 67117506, "end_pos": 67048897, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079432.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079432.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067474.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067474.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 134, "end_pos": 134, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser134" }, { "start_pos": 147, "end_pos": 147, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser147" }, { "start_pos": 160, "end_pos": 160, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser160" }, { "start_pos": 179, "end_pos": 179, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser179" }, { "start_pos": 248, "end_pos": 248, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser248" }, { "start_pos": 251, "end_pos": 251, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser251" }, { "start_pos": 252, "end_pos": 252, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser252" }, { "start_pos": 255, "end_pos": 255, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser255" }, { "start_pos": 316, "end_pos": 316, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser316" }, { "start_pos": 324, "end_pos": 324, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser324" }, { "start_pos": 378, "end_pos": 378, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser378" }, { "start_pos": 392, "end_pos": 392, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser392" }, { "start_pos": 414, "end_pos": 414, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser414" }, { "start_pos": 434, "end_pos": 434, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser434" }, { "start_pos": 43, "end_pos": 43, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser43" }, { "start_pos": 457, "end_pos": 457, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser457" }, { "start_pos": 463, "end_pos": 463, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser463" }, { "start_pos": 468, "end_pos": 468, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser468" }, { "start_pos": 48, "end_pos": 48, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser48" }, { "start_pos": 63, "end_pos": 63, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser63" }, { "start_pos": 88, "end_pos": 88, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "site_lbl": "Ser88" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534203", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534203", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AIE0-1", "protein_name": "SLAIN motif family, member 2", "gene_name": "Slain2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEDVNSNVNADQEVRKLQELVKKLEKQNEQLRSRSGAVQSAGLLGPGSPARAGVSTPSSGAASPRGFPLGLGAKASGGAGSGPRRTSSEDLRDATSLLAAGEGGLLDEVEPLRPDELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPSPDVECAKKSLIHKLDQTMSALKRQNLYNNPFNSMSYSSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNFKSSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDSMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRASPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASAIPSPGKFRSPAAPSPLALRQPVKAFSNHGSGSGSQETTQFTQTTSSPGPPVVQNTAPANPSSNINSATLTRPAGTAAMRSGLPRPSAPSAGGIPVPRSKLVQPVRRSLPAPKTYGSMKDDSWKDGCY", "length": 581 }, "evidence": [ { "id": "Q3MHV6", "url": "https://omabrowser.org/oma/group/Q3MHV6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8M3AW67-1", "protein_name": "SLAIN motif-containing protein 2 isoform X1", "gene_name": "slain2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEDINSNINADLEVRKLQDLVKKLEQQNEQLRSRSSLLSSSSPGGNTRPVSAGFDSPGAAAALAGFTGVGFGGSRGFDEALKNSRLSPRRSYHGSNYGDYDSDSGSFTTSNTSFASYYNDSLDYIEDGETSVLDEVEVLDLEDMDCLYEEEDSWLYEAKLNSPLQKTLSPIVWCRQALDNPSPDMESAKRSLLHRLDLTMSGNKRRSLYNSSYSPQVGYGSPYSTNTANSPYSSGFNSPSSTPSRVPIVKQLVLPGSTGHQRGSNDRNAQAVSPQSSVDSELSTSEMDEDSVGSSTTYKLNDVTDVQILARMQEESLRQEYAATASRRSSGSSCQSLRRGTLSDQELDAQSLEDDEEAVHHSYHTPVNRFSPSPRHSPRVSPRNSPRSRSPARSLEYSRGSPQNIISRLQQPRHSLQGHDTQTNAIKNEEKLRRSLPNLTRSSSGSTAEQVKNSRSCESNLQVPNGGSPRHQSQSAKSDHRLSAPVRLSPKPKERLQSPTSLRVPLSCCFGEEADFMPSSSKLRTPAAPSPLALRQPMKVVSNHGSGTTTPTRSMAPTRSGLPRPSTNAGGGLPVPRSKLVQPVRRSLPAPRTYSGIRDESWREGCY", "length": 607 }, "evidence": [ { "id": "Q3MHV6", "url": "https://omabrowser.org/oma/group/Q3MHV6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1SEA2-1", "protein_name": "SLAIN motif family member 2", "gene_name": "SLAIN2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEDVNSNVNADQEVRKLQELVKKLEKQNEQLRSRSGAVQGAGSLGPGSPVRTGGSTPSSGTASPRGFPLGLSAKSGSGAGTGPRRTSSEELRDATSLLAAGEGGLLDEVEPLRPEELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPSPDVECAKKSLIHKLDQTMSALKRQNLYNNPFNSMSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRVSPQPMISRLQQPRLSLQGHPTDLQTTNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASAIPSPGKFRSPAAPSPLALRQPVKAFSNHGSGSPSSQETVQLMQTTSSPGPPMVQNTVPANPSSNINSTTLTRPAGTTMMRSGLPRPSAPSAGGIPVPRSKLAQPVRRSLPAPKTYGSMKDDSWKDGCY", "length": 582 }, "evidence": [ { "id": "Q3MHV6", "url": "https://omabrowser.org/oma/group/Q3MHV6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8CI08-1", "protein_name": "SLAIN motif-containing protein 2", "gene_name": "Slain2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEDVNSNVNADQEVRKLQELVKKLEKQNEQLRSRSGAVQGAGLLGPGSPARVGVSTPSSGAASPRGFPLGLGAKASGGAGSGPRRTSSEDLRDATSLLAAGEGGLLDEVEPLRPDELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPSPDVECAKKSLIHKLDQTMSALKRQNLYNNPFNSVSYSNSYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNFKSSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAASTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDSLQHAVHPALNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRASPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSSTQVDSVKSSRSDSNFQVPNGGIPRMQPQASAIPSPGKFRSPAAPSPLALRQPVKAFSNHGSGSGSQETTQFTQTTSSPGPPVVQNSAPANPSSNINSATLTRPAGTTAMRSGLPRPSAPSAGGIPVPRSKLVQPVRRSLPAPKSYGSMKDDSWKDGCY", "length": 581 }, "evidence": [ { "id": "Q3MHV6", "url": "https://omabrowser.org/oma/group/Q3MHV6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P270-1", "protein_name": "SLAIN motif-containing protein 2", "gene_name": "SLAIN2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEDVNSNVNADQEVRKLQELVKKLEKQNEQLRSRSGAVQGAGSLGPGSPVRAGASIPSSGAASPRGFPLGLSAKSGGGPGSGPRRTSSEELRDATSLLAAGEGGLLDEVEPLRPDELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPSPDVECAKKSLIHKLDQTMSALKRQNLYNNPFNSMSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASAIPSPGKFRSPAAPSPLALRQPVKAFSNHGSGSPGSQEITQLTQTTSSPGPPMVQSTVSANPPSNINSATLTRPAGTTAMRSGLPRPSAPSAGGIPVPRSKLAQPVRRSLPAPKTYGSMKDDSWKDGCY", "length": 581 }, "evidence": [ { "id": "Q3MHV6", "url": "https://omabrowser.org/oma/group/Q3MHV6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "microtubule cytoskeleton", "id": "GO:0015630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "pmid": "" }, { "name": "microtubule plus-end", "id": "GO:0035371", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035371", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "pmid": "" }, { "name": "ciliary tip", "id": "GO:0097542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097542", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "microtubule nucleation", "id": "GO:0007020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007020", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "pmid": "" }, { "name": "positive regulation of microtubule polymerization", "id": "GO:0031116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031116", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "pmid": "" }, { "name": "cytoplasmic microtubule organization", "id": "GO:0031122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031122", "evidence": [ { "database": "UniProtKB", "id": "Q3MHV6", "url": "https://www.uniprot.org/uniprotkb/Q3MHV6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 203, "end_pos": 205, "annotation": "n_glycosylation_sequon" }, { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" }, { "start_pos": 417, "end_pos": 419, "annotation": "n_glycosylation_sequon" }, { "start_pos": 520, "end_pos": 522, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHV6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 582, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHV6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHV6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 43, 48, 63, 88, 134, 147, 160, 179, 248, 251, 252, 255, 316, 324, 378, 392, 414, 434, 457, 463, 468 ], "sequon_annotation_sites": [ { "start_pos": 203, "end_pos": 205 }, { "start_pos": 308, "end_pos": 310 }, { "start_pos": 417, "end_pos": 419 }, { "start_pos": 520, "end_pos": 522 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": 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"total", "count": 21 }, { "field": "total_sites", "count": 21 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHL7-1", "uniprot_ac": "Q3MHL7", "uniprot_id": "TCPZ_BOVIN", "mass": { "chemical_mass": 57956.0, "monoisotopic_mass": 57956.0 }, "refseq": { "ac": "NP_001029714", "name": "T-complex protein 1 subunit zeta", "summary": "", "url": 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The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance.", "evidence": [ { "database": "UniProtKB", "id": "Q3MHL7", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7#function" }, { "database": "UniProtKB", "id": "P40227", "url": "https://www.uniprot.org/uniprotkb/P40227#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHL7", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCT6A", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7", "locus": { "chromosome": "25", "start_pos": 27738084, "end_pos": 27727918, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008184", "url": "https://www.ensembl.org/id/ENSBTAG00000008184" } ] } } ], 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"database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027410", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027410", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053374", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053374", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521540", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521540", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LHPRIMT", "url": "https://omabrowser.org/oma/group/LHPRIMT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MGX0", "url": "https://www.orthodb.org/?gene=F1MGX0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3MHL7", "url": "https://www.orthodb.org/?gene=Q3MHL7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11353", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11353", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00003iyg", "url": "https://www.rcsb.org/structure/pdb_00003iyg", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00004b2t", "url": "https://www.rcsb.org/structure/pdb_00004b2t", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3IYG", "url": "https://www.rcsb.org/structure/3IYG", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4B2T", "url": "https://www.rcsb.org/structure/4B2T", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00118", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00118", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-390471", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390471", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6814122", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814122", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013418", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013418", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029714", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MGX0", "url": "https://www.uniprot.org/uniprotkb/F1MGX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGX0-1", "url": "https://www.uniprot.org/uniprotkb/F1MGX0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHL7", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHL7-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEQVKVSKEMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKKQDEPIDLFMVEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKKKVCGDSDKGFVVINQKGIDPFSLDALAKEGIIALRRAKRRNMERLTLACGGIALNSLDDLNPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRSVTLLIKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALVKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEHSESGQLVGVDLNTGEPMVAAEAGIWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG", "length": 531, "header": "sp|Q3MHL7-1|TCPZ_BOVIN Isoform 1 of T-complex protein 1 subunit zeta OS=Bos taurus OX=9913 GN=CCT6A PE=1 SV=3 CANONICAL=Q3MHL7-1" }, "isoforms": [ { "isoform_ac": "F1MGX0-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7/entry#F1MGX0-1", "sequence": { "sequence": "MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEQVKVSKEMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKKQDEPIDLFMVEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKKKVCGDSDKGFVVINQKGEEKFTFIEKCNNPRSVTLLIKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALVKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEHSESGQLVGVDLNTGKEDAAV", "length": 430, "header": "tr|F1MGX0-1|TCPZ_BOVIN Computationally mapped isoform of T-complex protein 1 subunit zeta OS=Bos taurus OX=9913 GN=CCT6A PE=1 SV=3 CANONICAL=Q3MHL7-1" }, "locus": { "chromosome": "25", "start_pos": 27735854, "end_pos": 27727997, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010765.8", "url": "https://www.ensembl.org/id/ENSBTAT00000010765.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010765.6", "url": "https://www.ensembl.org/id/ENSBTAP00000010765.6" } ] } }, { "isoform_ac": "Q3MHL7-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7/entry#Q3MHL7-1", "sequence": { "sequence": "MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEQVKVSKEMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKKQDEPIDLFMVEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKKKVCGDSDKGFVVINQKGIDPFSLDALAKEGIIALRRAKRRNMERLTLACGGIALNSLDDLNPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRSVTLLIKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALVKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEHSESGQLVGVDLNTGEPMVAAEAGIWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG", "length": 531, "header": "sp|Q3MHL7-1|TCPZ_BOVIN Isoform 1 of T-complex protein 1 subunit zeta OS=Bos taurus OX=9913 GN=CCT6A PE=1 SV=3 CANONICAL=Q3MHL7-1" }, "locus": { "chromosome": "25", "start_pos": 27737222, "end_pos": 27727997, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071259.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071259.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069251.1", "url": "https://www.ensembl.org/id/ENSBTAP00000069251.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 205, "end_pos": 205, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHL7", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ], "site_lbl": "Ser205" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q3MHL7", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:521540", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521540", "resource": "KEGG Pathway" }, { "id": "R-BTA-390471", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390471", "resource": "Reactome", "description": "Association of TriC/CCT with target proteins during biosynthesis" }, { "id": "R-BTA-6814122", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814122", "resource": "Reactome", "description": "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" }, { "id": "R-BTA-9013418", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013418", "resource": "Reactome", "description": "RHOBTB2 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZY35-1", "protein_name": "T-complex protein 1 subunit zeta", "gene_name": "Cct6a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEQVKVSKEMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIRKKDEPIDLFMVEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVENAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIVELKKKVCGDSDKGFVVINQKGIDPFSLDALAKEGIVALRRAKRRNMERLTLACGGIALNSFDDLNPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRSVTLLVKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVALAEALIKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEHSESGQLVGVDLNTGEPMVAAEMGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG", "length": 531 }, "evidence": [ { "id": "Q3MHL7", "url": "https://omabrowser.org/oma/group/Q3MHL7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3I2M1-1", "protein_name": "T-complex protein 1 subunit zeta", "gene_name": "Cct6a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAVKSLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEQVKVSREMDRETLIDVARTSLRTKVHAELADVLTEAVVDSVLSIKKTNEPIDLFMVEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVENAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKKNVCGDSDKGFVVINQKGIDPFSLDALAKEGIVALRRAKRRNMERLTLACGGIALNSLDDLNPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRSVTLLVKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAIEVAMAEALIKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEHSESGQLVGVDLNTGEPMVAAEMGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG", "length": 531 }, "evidence": [ { "id": "Q3MHL7", "url": "https://omabrowser.org/oma/group/Q3MHL7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3L9J4-1", "protein_name": "Chaperonin containing TCP1 subunit 6A", "gene_name": "CCT6A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEQVKVSKEMDRETLIDVARTSLRTKVHAELADVLTEAVVDSVLAIKKQDEPIDLFMVEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVRAERKFIEDRVKKIVELKKKVCGDSDKGFVVINQKGIDPFSLDALAKEGIVALRRAKRRNMERLTLACGGVALNSLDDLNPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRSVTLLIKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALIKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEHSESGQLVGVDLNTGEPMVAAEVGIWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG", "length": 531 }, "evidence": [ { "id": "Q3MHL7", "url": "https://omabrowser.org/oma/group/Q3MHL7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P39079-1", "protein_name": "T-complex protein 1 subunit zeta", "gene_name": "CCT6", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSLQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRSTLKETPQ", "length": 546 }, "evidence": [ { "id": "Q3MHL7", "url": "https://omabrowser.org/oma/group/Q3MHL7/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P40227-1", "protein_name": "T-complex protein 1 subunit zeta", "gene_name": "CCT6A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEEVKVSREMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKKQDEPIDLFMIEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKRKVCGDSDKGFVVINQKGIDPFSLDALSKEGIVALRRAKRRNMERLTLACGGVALNSFDDLSPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRSVTLLIKGPNKHTLTQIKDAVRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALIKHKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKIQAEHSESGQLVGVDLNTGEPMVAAEVGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG", "length": 531 }, "evidence": [ { "id": "Q3MHL7", "url": "https://omabrowser.org/oma/group/Q3MHL7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5ZJ54-1", "protein_name": "T-complex protein 1 subunit zeta", "gene_name": "CCT6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAVKALNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLQEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIVAEGFEIAKEKALEVLEQVKVTKEMDRETLIDVAKTSLRTKVHTELADILTEAVVDSVLAVRKPGEPIDLHMVEIMEMKHKSETDTTLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVSAGFFYKSAEEREKLVKAERKFIEDRVSKIIDLKRRVCGDSDKGFIVINQKGIDPFSLDALAKEGIVALRRAKRRNMERLTLACGGTAMNSVEDLTPDCLGHAGLVYEYTLGEEKYTFIEKCDNPRSVTLLIRGPNKHTLTQIKDAVRDGLRAVKNAIEDGCVIPGAGALEVAVANALVKHKPNVKGRAQLGVQAFADALLIIPKVLAQNSGYDPQETLVKVQAEHAESGQLTGVDLNTGEPMVAAAAGIWDNYNVKKQLLHSCTVIASNILLVDEIMRAGMSSLKG", "length": 530 }, "evidence": [ { "id": "Q3MHL7", "url": "https://omabrowser.org/oma/group/Q3MHL7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q76NU3-1", "protein_name": "T-complex protein 1 subunit zeta", "gene_name": "cct6", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLSMIKQQGAAADSRRGQALLLNISAGKGLQNVLKTNLGPRGTLKMLVGGGGDIKLTKDGKVLLHEMQIQHPTAALIARTATAQDDITGDGTTTNVITIGELLKQSERYLQENIHPRIIAEGFELAKDRCLAFLEEFKQTSQDTLDRELLISIAKTSLRTKLPADLADQLTEQVVDALLLIHKPEQPLDLFMVEIMTMQHRTDGHCSLIKGLVLDHGTRHPDMPKKLTNCFILTCNVSLEYEKTEVNANFLYKDHETRSRMIDGEHKLVAAKCRQIIELKNHVCDTPDKNFVVINQKGIDPICLDMLAKAGIMGLRRAKRRNMERLTLACGGTAMNSLEDLTPDCLGHADLVYEQTLGEEKYTFVEGVKNPFSCTVLIKGPTKHQIEQIKDALRDGLRAVKNTIEDKCVVPGGGAFQIAAYADLMKFKETITGRTKLGIQAFADALLVVPKTLAQNSGFDPMDTIIKLQEEYAKGHIVGLDVESGEPMDPVSEGIFDQYSVLKQVYRSSPVIASQLLLIDEIIKAGKGMRGSSVPEGQE", "length": 539 }, "evidence": [ { "id": "Q3MHL7", "url": "https://omabrowser.org/oma/group/Q3MHL7/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9M888-1", "protein_name": "T-complex protein 1 subunit zeta 1", "gene_name": "CCT6A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSVRVLNPNAEVLNKSAALHMTINAAKGLQDVLKSNLGPKGTIKMLVGGSGDIKLTKDGNTLLKEMQIQNPTAIMIARTAVAQDDISGDGTTSTVIFIGELMKQSERCIDEGMHPRVLVDGFEIAKRATLQFLDTFKTPVVMGDEPDKEILKMVARTTLRTKLYEGLADQLTDIVVNSVLCIRKPQEPIDLFMVEIMHMRHKFDVDTRLVEGLVLDHGSRHPDMKRRAENCHILTCNVSLEYEKSEINAGFFYSNAEQREAMVTAERRSVDERVQKIIELKNKVCAGNDNSFVILNQKGIDPPSLDLLAREGIIALRRAKRRNMERLVLACGGEAVNSVDDLTPDCLGWAGLVYEHVLGEEKYTFVEQVKNPHSCTILIKGPNDHTIAQIKDAVRDGLRSVKNTLEDECVVLGAGAFEVAARQHLINEVKKTVQGRAQLGVEAFANALLVVPKTLAENAGLDTQDVIISLTSEHDKGNIVGLDLQDGEPVDPQLAGIFDNYSVKRQLINSGPVIASQLLLVDEVIRAGRNMRKPT", "length": 535 }, "evidence": [ { "id": "Q3MHL7", "url": "https://omabrowser.org/oma/group/Q3MHL7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VXQ5-1", "protein_name": "Chaperonin containing TCP1 subunit 6", "gene_name": "CCT6", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MASISLLNPKAEFARAAQALAINISAAKGLQDVMRTNLGPKGTVKMLVSGAGDIKITKDGNVLLHEMQIQHPTASMIARASTAQDDSTGDGTTTTVMLIGELLKQADIYLSEGLHPRIMTDGFEKARDKALEVLDQVKVPVEINKKNLVEVANTSLKTKVHPALADLLTDVCVNAVLTIASADKTKPVDLHMVELMEMQHKSDTDTQLVRGLVMDHGARHPDMPKRLENAYILTANVSLEYEKAEVNSGFFYKTAEEREAFVRAEREFIDQRVKKVIELKRSVCDGTDKTFVLINQKGIDPISLDALAKEGILALRRAKRRNMERLSLACGGTAMNSFDDLQEEHLGYAGVVYEHVLGENKYTFVEDCKNPLSVTILIKGPNKHTITQIKDAIRDGLRAINNTIADKALVPGAGAFEVRAYNELVAFKDTIKGKSRLAVQAFADALLVIPKTLAVNSGYDAQDTIVKLTVEDRLSPELVGLDLATGEPMKPVDLGVYDNYIVKKQILNSCSIIASNLLLVDEVMRAGMTSLKG", "length": 533 }, "evidence": [ { "id": "Q3MHL7", "url": "https://omabrowser.org/oma/group/Q3MHL7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q3MHL7", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3MHL7", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ], "pmid": "" }, { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "Q3MHL7", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q3MHL7", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ], "pmid": "" }, { "name": "WD40-repeat domain binding", "id": "GO:0071987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071987", "evidence": [ { "database": "UniProtKB", "id": "Q3MHL7", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ], "pmid": "" }, { "name": "ATP-dependent protein folding chaperone", "id": "GO:0140662", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140662", "evidence": [ { "database": "UniProtKB", "id": "Q3MHL7", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "Q3MHL7", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ], "pmid": "" }, { "name": "chaperonin-containing T-complex", "id": "GO:0005832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005832", "evidence": [ { "database": "UniProtKB", "id": "Q3MHL7", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "Q3MHL7", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ], "pmid": "" }, { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "Q3MHL7", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" }, { "start_pos": 23, "end_pos": 25, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] }, { "id": "R-BTA-391266", "name": "Association of CCT/TriC with sphingosine kinase 1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-391266", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-391266" } ] }, { "id": "R-BTA-6814119", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6814119", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814119" } ] }, { "id": "R-BTA-6814120", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6814120", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814120" } ] }, { "id": "R-BTA-6814121", "name": "PDCL binds G-protein beta and TRiC/CCT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6814121", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814121" } ] }, { "id": "R-BTA-6814124", "name": "ATP binds G-protein beta associated TRiC/CCT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6814124", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814124" } ] }, { "id": "R-BTA-8850527", "name": "PDCL releases folded G-beta from TRiC/CCT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-8850527", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8850527" } ] }, { "id": "R-BTA-8850529", "name": "RGS proteins bind GNB5 and CCT/TRiC", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-8850529", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8850529" } ] }, { "id": "R-BTA-8850534", "name": "PDCL promotes G-protein beta 5 folding", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-8850534", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8850534" } ] }, { "id": "R-BTA-8850539", "name": "Release of GNB5:RGS dimers from CCT/TRiC", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-8850539", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8850539" } ] }, { "id": "R-BTA-9018787", "name": "RHOBTB2 binds interacting proteins at the endosome membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endosome membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "P60712-1", "A2VDV2-1", "Q3T147-1", "Q3MHL7-1" ], "evidence": [ { "id": "R-BTA-9018787", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9018787" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + 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"id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLQ5", "database": 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"evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { 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The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2NKT2", "url": "https://www.uniprot.org/uniprotkb/Q2NKT2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NKT2", "url": "https://www.uniprot.org/uniprotkb/Q2NKT2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "INIP", "url": "https://www.uniprot.org/uniprotkb/Q2NKT2", "locus": { "chromosome": "8", "start_pos": 101928505, "end_pos": 101990100, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019275", "url": "https://www.ensembl.org/id/ENSBTAG00000019275" } ] } } ], "crossref": [ { "id": "Q2NKT2", "url": 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"https://www.uniprot.org/uniprotkb/Q2NKW0" } ] }, { "name": "BLOC1S1", "type": "synonym", "evidence": [ { "id": "NP_001069830", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069830" } ] } ], "protein_names": [ { "name": "Biogenesis of lysosome-related organelles complex 1 subunit 1", "type": "recommended", "evidence": [ { "id": "Q2NKW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0/entry#names_and_taxonomy" } ] }, { "name": "2.3.1.-", "type": "synonym", "evidence": [ { "id": "Q2NKW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0/entry#names_and_taxonomy" } ] }, { "name": "BLOC-1 subunit 1", "type": "synonym", "evidence": [ { "id": "NP_001069830", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069830" }, { "id": "Q2NKW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0/entry#names_and_taxonomy" } ] }, { "name": "Protein acetyltransferase BLOC1S1", "type": "synonym", "evidence": [ { "id": "Q2NKW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0/entry#names_and_taxonomy" } ] }, { "name": "biogenesis of lysosome-related organelles complex 1 subunit 1", "type": "synonym", "evidence": [ { "id": "NP_001069830", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069830" } ] }, { "name": "biogenesis of lysosome-related organelles complex-1, subunit 1", "type": "synonym", "evidence": [ { "id": "NP_001069830", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069830" } ] }, { "name": "protein acetyltransferase BLOC1S1", "type": "synonym", "evidence": [ { "id": "NP_001069830", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069830" } ] } ], "function": [ { "annotation": "Acts as a protein acetyltransferase. Negatively regulates aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9. Acts as a regulator of mTORC2 signaling in response to hypotoxic stress by mediating acetylation of RICTOR, thereby protecting RICTOR against ubiquitination and subsequent degradation by the proteasome.", "evidence": [ { "database": "UniProtKB", "id": "Q2NKW0", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0#function" }, { "database": "UniProtKB", "id": "P78537", "url": "https://www.uniprot.org/uniprotkb/P78537#function" } ] }, { "annotation": "Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. The BORC complex is most probably associated with the cytosolic face of lysosomes, may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.", "evidence": [ { "database": "UniProtKB", "id": "Q2NKW0", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0#function" }, { "database": "UniProtKB", "id": "P78537", "url": "https://www.uniprot.org/uniprotkb/P78537#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NKW0", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BLOC1S1", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0", "locus": { "chromosome": "5", "start_pos": 57536797, "end_pos": 57541904, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011918", "url": "https://www.ensembl.org/id/ENSBTAG00000011918" } ] } } ], "crossref": [ { "id": "Q2NKW0", "url": "https://alphafold.ebi.ac.uk/entry/Q2NKW0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011918", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011918", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615149", "url": "https://www.ncbi.nlm.nih.gov/gene/615149", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615149", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615149", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WMKIMEY", "url": "https://omabrowser.org/oma/group/WMKIMEY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NKW0", "url": "https://www.orthodb.org/?gene=Q2NKW0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13073", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13073", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13073:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13073:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06320", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06320", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-432720", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432720", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-432722", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432722", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001069830", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069830", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "45948", "url": "https://www.rhea-db.org/rhea/45948", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2NKW0", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NKW0-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSRLLKEHQAKQNERKELQEKRRREAITAATCLTEALVDHLNVGVAQAYMNQRKLDHEVKTLQVQAAQFAKQTGQWIGMVENFNQALKEIGDVENWARSIELDMRTIATALEYVYKGQLQSAPS", "length": 125, "header": "sp|Q2NKW0-1|BL1S1_BOVIN Isoform 1 of Biogenesis of lysosome-related organelles complex 1 subunit 1 OS=Bos taurus OX=9913 GN=BLOC1S1 PE=2 SV=1 CANONICAL=Q2NKW0-1" }, "isoforms": [ { "isoform_ac": "Q2NKW0-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0/entry#Q2NKW0-1", "sequence": { "sequence": "MLSRLLKEHQAKQNERKELQEKRRREAITAATCLTEALVDHLNVGVAQAYMNQRKLDHEVKTLQVQAAQFAKQTGQWIGMVENFNQALKEIGDVENWARSIELDMRTIATALEYVYKGQLQSAPS", "length": 125, "header": "sp|Q2NKW0-1|BL1S1_BOVIN Isoform 1 of Biogenesis of lysosome-related organelles complex 1 subunit 1 OS=Bos taurus OX=9913 GN=BLOC1S1 PE=2 SV=1 CANONICAL=Q2NKW0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:615149", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615149", "resource": "KEGG Pathway" }, { "id": "R-BTA-432720", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432720", "resource": "Reactome", "description": "Lysosome Vesicle Biogenesis" }, { "id": "R-BTA-432722", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432722", "resource": "Reactome", "description": "Golgi Associated Vesicle Biogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q3B116-1", "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 1", "gene_name": "BLOC1S1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLSRLLREHQARQSERRELQERRRREAIAAATRLTEALVDHLNVGVAQAYVNQRKLDQEVKTLQAQAAQFAKQTGQWITMVENFNQALKEIGDVENWARSIELDMRTIATALEYIYKGQLQPACS", "length": 125 }, "evidence": [ { "id": "Q2NKW0", "url": "https://omabrowser.org/oma/group/Q2NKW0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A4X1W434-1", "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 1", "gene_name": "BLOC1S1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLSRLLKEHQAKQNERKELQEKRRREAITAATCLTEALVDHLNVGVAQAYMNQRKLDHEVKTLQVQAAQFAKQTGQWIGMVENFNQALKEIGDVENWARSIELDMRTIATALEYVYKGQLQSAPS", "length": 125 }, "evidence": [ { "id": "Q2NKW0", "url": "https://omabrowser.org/oma/group/Q2NKW0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A1Z9S1-1", "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 1", "gene_name": "Blos1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLTSMVKEHHKEQAKRKQEQEVRRKEAIEASNELTQSLVDTLNVGVAQAYLNQKRLDAEAKQLHLGATNFAKQTHQWLQLIDQFSTALKDLGDVENWARSIEGDMHTINQTLELAYKASRATQTSSGAGTSLEASTSASASANPSAT", "length": 147 }, "evidence": [ { "id": "Q2NKW0", "url": "https://omabrowser.org/oma/group/Q2NKW0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "O22929-1", "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 1", "gene_name": "BLOS1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MNTPMSLSAARGRMLPFLEKEKSEEESETLESSLLQLIDDNRRSSLQLREKTERSRKEAIRHAARTADLLVKAVNGGVEECFVNEKRIESEIRNLAITVAKFGKQTDQWLAVTHAVNSAVKEIGDFENWMKTMEFDCKKITAAIRNIHEDQQ", "length": 152 }, "evidence": [ { "id": "Q2NKW0", "url": "https://omabrowser.org/oma/group/Q2NKW0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "O55102-1", "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 1", "gene_name": "Bloc1s1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSRLLKEHQAKQNERKELQEKRRREAIAAATCLTEALVDHLNVGVAQAYMNQRKLDHEVKTLQVQAAQFAKQTGQWIGMVENFNQALKEIGDVENWARSIELDMRTIATALEYVYKGQLQSAPS", "length": 125 }, "evidence": [ { "id": "Q2NKW0", "url": "https://omabrowser.org/oma/group/Q2NKW0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54VX7-1", "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 1", "gene_name": "bloc1s1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLSKLVKDHQTHQNKLKEENEVLKKEAIASMGVVTNGLIDSVNTGVACIFANQKKLETEARLLQANTAKFSKQTNQWIHLIENFNNSLKEIGDVENWSKKIESDMHNISDIIEFLYINSNPIQQQPQQQPQQQQQ", "length": 135 }, "evidence": [ { "id": "Q2NKW0", "url": "https://omabrowser.org/oma/group/Q2NKW0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-lysine-acetyltransferase activity", "id": "GO:0061733", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061733", "evidence": [ { "database": "UniProtKB", "id": "Q2NKW0", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "mitochondrial intermembrane space", "id": "GO:0005758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005758", "evidence": [ { "database": "UniProtKB", "id": "Q2NKW0", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q2NKW0", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2NKW0", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "Q2NKW0", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0" } ], "pmid": "" }, { "name": "axon cytoplasm", "id": "GO:1904115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904115", "evidence": [ { "database": "UniProtKB", "id": "Q2NKW0", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0" } ], "pmid": "" }, { "name": "BORC complex", "id": "GO:0099078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099078", "evidence": [ { "database": "UniProtKB", "id": "Q2NKW0", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0" } ], "pmid": "" }, { "name": "BLOC-1 complex", "id": "GO:0031083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031083", "evidence": [ { "database": "UniProtKB", "id": "Q2NKW0", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "neuron projection development", "id": "GO:0031175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031175", "evidence": [ { "database": "UniProtKB", "id": "Q2NKW0", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0" } ], "pmid": "" }, { "name": "endosomal transport", "id": "GO:0016197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016197", "evidence": [ { "database": "UniProtKB", "id": "Q2NKW0", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0" } ], "pmid": "" }, { "name": "anterograde axonal transport", "id": "GO:0008089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008089", "evidence": [ { "database": "UniProtKB", "id": "Q2NKW0", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0" } ], "pmid": "" }, { "name": "anterograde synaptic vesicle transport", "id": "GO:0048490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048490", "evidence": [ { "database": "UniProtKB", "id": "Q2NKW0", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0" } ], "pmid": "" }, { "name": "lysosome localization", "id": "GO:0032418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032418", "evidence": [ { "database": "UniProtKB", "id": "Q2NKW0", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0" } ], "pmid": "" }, { "name": "aerobic respiration", "id": "GO:0009060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009060", "evidence": [ { "database": "UniProtKB", "id": "Q2NKW0", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0" } ], "pmid": "" }, { "name": "peptidyl-lysine acetylation", "id": "GO:0018394", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018394", "evidence": [ { "database": "UniProtKB", "id": "Q2NKW0", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "45948", "name": "", "equation": "L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1MAE0-1", "A0A3Q1MLT2-1", "F2Z4J6-1", "F1MP98-1", "E1BEB3-1", "Q17QK9-1", "Q2KIN8-1", "A0A3Q1LU60-1", "A7YY28-1", "A0A3S5ZPM2-1", "A0ABZ3NNH7-1", "Q2NKW0-1", "F1MVD0-1" ], "evidence": [ { "id": "45948", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45948" } ] }, { "id": "R-BTA-429815", "name": "Formation Of Bloc-1 Complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LUG9-1", "Q2NKW0-1" ], "evidence": [ { "id": "R-BTA-429815", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-429815" } ] }, { "id": "R-BTA-432706", "name": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi membrane, cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P84080-1", "A0ABI0NJH4-1", "F1MZ33-1", "P05689-1", "A0A3Q1LUG9-1", "Q2NKW0-1" ], "evidence": [ { "id": "R-BTA-432706", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432706" } ] }, { "id": "R-BTA-432707", "name": "trans-Golgi Network Lysosomal Vesicle Scission", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0ABI0NJH4-1", "F1MZ33-1", "P05689-1", "A0A3Q1LUG9-1", "Q2NKW0-1" ], "evidence": [ { "id": "R-BTA-432707", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432707" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LU60", "gene_name": "KAT6B", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "A0A3Q1LU60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU60" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A3Q1LU60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU60" } ] } ] }, { "uniprot_ac": "A0A3Q1LUG9", "gene_name": "TXNDC5", "activity": [ { "ec_number": 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N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "A0A3Q1MLT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLT2" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A3Q1MLT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLT2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPM2", "gene_name": "HAT1", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "A0A3S5ZPM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPM2" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A3S5ZPM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPM2" } ] } ] }, { "uniprot_ac": "A0ABI0NJH4", "gene_name": "GNS", "activity": [ { "ec_number": "3.1.6.14", "activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of 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"https://www.uniprot.org/uniprotkb/A7YY28" } ] } ] }, { "uniprot_ac": "E1BEB3", "gene_name": "KAT6A", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "E1BEB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEB3" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "E1BEB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEB3" } ] } ] }, { "uniprot_ac": "F1MP98", "gene_name": "KAT8", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "F1MP98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP98" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "F1MP98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP98" } ] } ] }, { "uniprot_ac": "F1MVD0", "gene_name": "NCOA3", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "F1MVD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVD0" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "F1MVD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVD0" } ] } ] }, { "uniprot_ac": "F1MZ33", "gene_name": "DNASE2", "activity": [ { "ec_number": "3.1.22.1", "activity": "Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products.", "evidence": [ { "id": "F1MZ33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZ33" } ] }, { "ec_number": "3.1.22.1", "activity": "", "evidence": [ { "id": "F1MZ33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZ33" } ] } ] }, { "uniprot_ac": "F2Z4J6", "gene_name": "GTF2B", "activity": [ { "ec_number": "2.3.1.48", 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"gene_name": "BLOC1S1", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q2NKW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NKW0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 125, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NKW0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NKW0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", 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"https://www.uniprot.org/uniprotkb/Q2NKZ4/entry#names_and_taxonomy" } ] }, { "name": "transketolase-like protein 2", "type": "synonym", "evidence": [ { "id": "NP_001039490", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039490" } ] } ], "function": [ { "annotation": "Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2NKZ4", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4#function" }, { "database": "UniProtKB", "id": "Q9H0I9", "url": "https://www.uniprot.org/uniprotkb/Q9H0I9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NKZ4", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TKTL2", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4", "locus": { "chromosome": "6", "start_pos": 2171074, "end_pos": 2142353, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008947", "url": "https://www.ensembl.org/id/ENSBTAG00000008947" } ] } } ], "crossref": [ { "id": "Q2NKZ4", "url": "https://alphafold.ebi.ac.uk/entry/Q2NKZ4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008947", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008947", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02012", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02012", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07033", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07033", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509186", "url": "https://www.ncbi.nlm.nih.gov/gene/509186", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005474", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005474", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005475", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005475", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020826", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020826", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029061", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029061", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033248", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033248", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509186", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509186", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VRVIHVM", "url": "https://omabrowser.org/oma/group/VRVIHVM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NKZ4", "url": "https://www.orthodb.org/?gene=Q2NKZ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43195", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43195", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43195:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43195:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00456", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00456", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02779", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02779", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02780", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02780", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039490", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10508", "url": "https://www.rhea-db.org/rhea/10508", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2NKZ4", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NKZ4-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADSATLDATTVQVLQDLANRLRVHSIRATCASGSGHPTSCCSAAEIVSVLFFHTMRYRQTEPAHPDNDRFVLSKGHAAPLLYAAWVEAGSISEPDLLNLRTIHCDLEGHPTPRLSFVDVATGSLGQGLGAACGMAYTGKYLDKASYRVFCLLGDGESSEGSVWEALAFASHYGLDNLVAVFDVNRLGQSGVAPLKHCTDIYRNRCEAFGWNTYLVDGHDVEALCQAFSQAAQGKNKPTAIIAKTYKGRGIPNVEDAENWHGKPLPKERADEIIRLIKSQIKTNRNLLPKPPVEGSPPVSITNIKMTCLPDYKVGDKVATQKAYGLALAKLGLANERVVVLDGDPKNSTFFEIFKKEHPERFIECFAAEQNMVSVALGCATRGRTITFVTTLGAFLTRAFDQIRMGAISQSNINLIGSHCGVSVGEDGPSQMALEDLAMFRSIPNCTVFLPSDAVSTEHAVYLAANSEGMCFIRTNRSETAVIYTPQEHFEIGRAKVIRHSNNDKVTVIGAGVTLHEALAAADALSQQDISICVIDPFTIKPLDAATIISCAKATDGRVVTVEDHYQEGGIGEAVCAAVSGEPAIHVHQLSVSGVSERNRKPSELLSIFGVSARHIIAAVKYTLMN", "length": 626, "header": "sp|Q2NKZ4-1|TKTL2_BOVIN Isoform 1 of Transketolase-like protein 2 OS=Bos taurus OX=9913 GN=TKTL2 PE=2 SV=1 CANONICAL=Q2NKZ4-1" }, "isoforms": [ { "isoform_ac": "Q2NKZ4-1", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4/entry#Q2NKZ4-1", "sequence": { "sequence": "MADSATLDATTVQVLQDLANRLRVHSIRATCASGSGHPTSCCSAAEIVSVLFFHTMRYRQTEPAHPDNDRFVLSKGHAAPLLYAAWVEAGSISEPDLLNLRTIHCDLEGHPTPRLSFVDVATGSLGQGLGAACGMAYTGKYLDKASYRVFCLLGDGESSEGSVWEALAFASHYGLDNLVAVFDVNRLGQSGVAPLKHCTDIYRNRCEAFGWNTYLVDGHDVEALCQAFSQAAQGKNKPTAIIAKTYKGRGIPNVEDAENWHGKPLPKERADEIIRLIKSQIKTNRNLLPKPPVEGSPPVSITNIKMTCLPDYKVGDKVATQKAYGLALAKLGLANERVVVLDGDPKNSTFFEIFKKEHPERFIECFAAEQNMVSVALGCATRGRTITFVTTLGAFLTRAFDQIRMGAISQSNINLIGSHCGVSVGEDGPSQMALEDLAMFRSIPNCTVFLPSDAVSTEHAVYLAANSEGMCFIRTNRSETAVIYTPQEHFEIGRAKVIRHSNNDKVTVIGAGVTLHEALAAADALSQQDISICVIDPFTIKPLDAATIISCAKATDGRVVTVEDHYQEGGIGEAVCAAVSGEPAIHVHQLSVSGVSERNRKPSELLSIFGVSARHIIAAVKYTLMN", "length": 626, "header": "sp|Q2NKZ4-1|TKTL2_BOVIN Isoform 1 of Transketolase-like protein 2 OS=Bos taurus OX=9913 GN=TKTL2 PE=2 SV=1 CANONICAL=Q2NKZ4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:509186", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509186", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9H0I9-1", "protein_name": "Transketolase-like protein 2", "gene_name": "TKTL2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMANDAKPDVKTVQVLRDTANRLRIHSIRATCASGSGQLTSCCSAAEVVSVLFFHTMKYKQTDPEHPDNDRFILSRGHAAPILYAAWVEVGDISESDLLNLRKLHSDLERHPTPRLPFVDVATGSLGQGLGTACGMAYTGKYLDKASYRVFCLMGDGESSEGSVWEAFAFASHYNLDNLVAVFDVNRLGQSGPAPLEHGADIYQNCCEAFGWNTYLVDGHDVEALCQAFWQASQVKNKPTAIVAKTFKGRGIPNIEDAENWHGKPVPKERADAIVKLIESQIQTNENLIPKSPVEDSPQISITDIKMTSPPAYKVGDKIATQKTYGLALAKLGRANERVIVLSGDTMNSTFSEIFRKEHPERFIECIIAEQNMVSVALGCATRGRTIAFAGAFAAFFTRAFDQLRMGAISQANINLIGSHCGVSTGEDGVSQMALEDLAMFRSIPNCTVFYPSDAISTEHAIYLAANTKGMCFIRTSQPETAVIYTPQENFEIGQAKVVRHGVNDKVTVIGAGVTLHEALEAADHLSQQGISVRVIDPFTIKPLDAATIISSAKATGGRVITVEDHYREGGIGEAVCAAVSREPDILVHQLAVSGVPQRGKTSELLDMFGISTRHIIAAVTLTLMK", "length": 626 }, "evidence": [ { "id": "Q2NKZ4", "url": "https://omabrowser.org/oma/group/Q2NKZ4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2NKZ4", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q2NKZ4", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4" } ], "pmid": "" }, { "name": "thiamine pyrophosphate binding", "id": "GO:0030976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030976", "evidence": [ { "database": "UniProtKB", "id": "Q2NKZ4", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4" } ], "pmid": "" }, { "name": "transketolase activity", "id": "GO:0004802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004802", "evidence": [ { "database": "UniProtKB", "id": "Q2NKZ4", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 445, "end_pos": 447, "annotation": "n_glycosylation_sequon" }, { "start_pos": 476, "end_pos": 478, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10508", "name": "", "equation": "D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NL26-1", "Q2NKZ4-1", "Q6B855-1" ], "evidence": [ { "id": "10508", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10508" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q2NKZ4", "gene_name": "TKTL2", "activity": [ { "ec_number": "2.2.1.1", "activity": "D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate.", "evidence": [ { "id": "Q2NKZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4" } ] }, { "ec_number": "2.2.1.1", "activity": "", "evidence": [ { "id": "Q2NKZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4" } ] } ] }, { "uniprot_ac": "Q2NL26", "gene_name": "TKTL1", "activity": [ { "ec_number": "2.2.1.1", "activity": "D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate.", "evidence": [ { "id": "Q2NL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL26" } ] }, { "ec_number": "2.2.1.1", "activity": "", "evidence": [ { "id": "Q2NL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL26" } ] } ] }, { "uniprot_ac": "Q6B855", "gene_name": "TKT", "activity": [ { "ec_number": "2.2.1.1", "activity": "D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate.", "evidence": [ { "id": "Q6B855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6B855" } ] }, { "ec_number": "2.2.1.1", "activity": "", "evidence": [ { "id": "Q6B855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6B855" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NKZ4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 626, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NKZ4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NKZ4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q2NKZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4#function" }, { "id": "Q2NKZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4" } ], "binding_site_uniprot": 155, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 155, "end_pos": 155, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2NKZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4#function" }, { "id": "Q2NKZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4" } ], "binding_site_uniprot": 185, "amino_acid": "Asn", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 185, "end_pos": 185, "start_aa": "Asn", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2NKZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4#function" }, { "id": "Q2NKZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4" } ], "binding_site_uniprot": 187, "amino_acid": "Leu", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 187, "end_pos": 187, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.2.1.1", "ec_name": "D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate.", "evidence": [ { "id": "2.2.1.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.2.1.1" }, { "id": "2.2.1.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.2.1.1" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 347, "end_pos": 349 }, { "start_pos": 445, "end_pos": 447 }, { "start_pos": 476, "end_pos": 478 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2NL00-1", "uniprot_ac": "Q2NL00", "uniprot_id": "GSTT1_BOVIN", "mass": { "chemical_mass": 27149.0, "monoisotopic_mass": 27149.0 }, "refseq": { "ac": "NP_001039697", "name": "glutathione S-transferase theta-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039697" }, "gene_names": [ { "name": "GSTT1", "type": "recommended", "evidence": [ { "id": "Q2NL00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL00" } ] }, { "name": "GSTT1", "type": "synonym", "evidence": [ { "id": "NP_001039697", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039697" } ] } ], "protein_names": [ { "name": "Glutathione S-transferase theta-1", "type": "recommended", "evidence": [ { "id": "Q2NL00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL00/entry#names_and_taxonomy" } ] }, { "name": "2.5.1.18", "type": "synonym", "evidence": [ { "id": "Q2NL00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL00/entry#names_and_taxonomy" } ] }, { "name": "GST class-theta-1", "type": "synonym", "evidence": [ { "id": "NP_001039697", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039697" }, { "id": "Q2NL00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL00/entry#names_and_taxonomy" } ] }, { "name": "glutathione S-transferase theta-1", "type": "synonym", "evidence": [ { "id": "NP_001039697", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039697" } ] } ], "function": [ { "annotation": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q2NL00", "url": "https://www.uniprot.org/uniprotkb/Q2NL00#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NL00", "url": "https://www.uniprot.org/uniprotkb/Q2NL00" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GSTT1", "url": "https://www.uniprot.org/uniprotkb/Q2NL00", "locus": { "chromosome": "17", "start_pos": 71326529, "end_pos": 71318878, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040298", "url": "https://www.ensembl.org/id/ENSBTAG00000040298" } ] } } ], "crossref": [ { "id": "Q2NL00", "url": "https://alphafold.ebi.ac.uk/entry/Q2NL00", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040298", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040298", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03050", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03050", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03183", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03183", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517724", "url": "https://www.ncbi.nlm.nih.gov/gene/517724", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004045", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004045", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004046", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004046", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010987", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010987", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040075", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040075", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040077", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040077", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051369", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051369", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517724", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517724", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CQYRVDE", "url": "https://omabrowser.org/oma/group/CQYRVDE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NL00", "url": "https://www.orthodb.org/?gene=Q2NL00", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43917", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43917", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43917:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43917:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00043", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00043", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02798", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02798", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156590", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156590", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9753281", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9753281", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039697", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16437", "url": "https://www.rhea-db.org/rhea/16437", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2NL00", "url": "https://www.uniprot.org/uniprotkb/Q2NL00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NL00-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL00-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLELYLDLLSQPCRAIYIFAKKNRIPFELRTVDLRKGQHLSDAFAQVNPLQKVPILKDGDFILTESVAILLYLARKYKVPDHWYPQDLQACARVDEYLAWQHTALRRNCLRALWHKVMLPVFLGEPVSPEMLATTLAELDMALQVLEGKFLQDKAFLTGSHISLADLVAITELMHPVGAGCQVFKGRPKLAAWRQRVEAAVGEVLFQEAHEVILKAKDSQPADPTLKQKMLPKVLAMIQ", "length": 240, "header": "sp|Q2NL00-1|GSTT1_BOVIN Isoform 1 of Glutathione S-transferase theta-1 OS=Bos taurus OX=9913 GN=GSTT1 PE=2 SV=3 CANONICAL=Q2NL00-1" }, "isoforms": [ { "isoform_ac": "Q2NL00-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL00/entry#Q2NL00-1", "sequence": { "sequence": "MGLELYLDLLSQPCRAIYIFAKKNRIPFELRTVDLRKGQHLSDAFAQVNPLQKVPILKDGDFILTESVAILLYLARKYKVPDHWYPQDLQACARVDEYLAWQHTALRRNCLRALWHKVMLPVFLGEPVSPEMLATTLAELDMALQVLEGKFLQDKAFLTGSHISLADLVAITELMHPVGAGCQVFKGRPKLAAWRQRVEAAVGEVLFQEAHEVILKAKDSQPADPTLKQKMLPKVLAMIQ", "length": 240, "header": "sp|Q2NL00-1|GSTT1_BOVIN Isoform 1 of Glutathione S-transferase theta-1 OS=Bos taurus OX=9913 GN=GSTT1 PE=2 SV=3 CANONICAL=Q2NL00-1" }, "locus": { "chromosome": "17", "start_pos": 71326263, "end_pos": 71318921, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007403.5", "url": "https://www.ensembl.org/id/ENSBTAT00000007403.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007403.3", "url": "https://www.ensembl.org/id/ENSBTAP00000007403.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:517724", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517724", "resource": "KEGG Pathway" }, { "id": "R-BTA-156590", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156590", "resource": "Reactome", "description": "Glutathione conjugation" }, { "id": "R-BTA-9753281", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9753281", "resource": "Reactome", "description": "Paracetamol ADME" } ], "orthologs": [ { "uniprot_canonical_ac": "A1Z7X7-1", "protein_name": "1.11.1.9", "gene_name": "GstT2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSKPIRFYYDLLSPIARGLWIGLKFSNSPVEYCPIALRKFEQLTDEYKKINRFQKVPAIVGGDFHLSETIAIIRYLADKGQFDEKLYPKTLENRARVDEFLEWQHLNIRLACSMYFRDAWLFPMNGIAPKPKPEQIQALIEGVENNLGLLERLWLENDFLVGKNLTMADILGSSEINQLRLCQYRVDEKKFPKVVKWLERVRVSANPYHDEGLTFIDRKSKQSTAAKL", "length": 228 }, "evidence": [ { "id": "Q2NL00", "url": "https://omabrowser.org/oma/group/Q2NL00/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "F1RL37-1", "protein_name": "glutathione transferase", "gene_name": "LOC100153094", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGLELYLDLLSQPCRAIYIFAKKNGIPFELRTVDLRKGQHLSGAFAQVNPLQKVPVLKDGDFILTESVAILLYLTRKYKVPDHWYPQDLQACAQVDEYLAWQHTTLRRNCLRALWHKVMLPVFMGELVSPETLGTTLAELDVTLQVLEDKFLQSKAFLAGPHISLADLVAITELMHPVGAGCQVFEGRPKLAAWRQRVEVAIGEVLFQEAHEVILKAKDSQPVDPTLKQKLLPKVLAMIQ", "length": 240 }, "evidence": [ { "id": "Q2NL00", "url": "https://omabrowser.org/oma/group/Q2NL00/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HY05-1", "protein_name": "glutathione transferase", "gene_name": "LOC100768553", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVLELYLDLLSQPCRAIYIFAKKNGIPFQMHTVELRKGEHLSDAFAQVNPMKKVPAMKDNDFTLSESVAILLYLTHKYKVPDHWYPQELQARARVDEYLAWQHTALRRSCLRALWHKVMFPVFLGEQVPSETLAATLAELDVNLQVLEDKFLQDKAFLIGSHISLADLVAITELMHPVGGGCPVFEGRPKLAAWYHRVEAAVGKDLFREAHEVILKAKDSPPANLIMKQKLMPRVLAMIQ", "length": 240 }, "evidence": [ { "id": "Q2NL00", "url": "https://omabrowser.org/oma/group/Q2NL00/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q01579-1", "protein_name": "Glutathione S-transferase theta-1", "gene_name": "Gstt1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVLELYLDLLSQPCRAIYIFAKKNNIPFQMHTVELRKGEHLSDAFAQVNPMKKVPAMKDGGFTLCESVAILLYLAHKYKVPDHWYPQDLQARARVDEYLAWQHTTLRRSCLRTLWHKVMFPVFLGEQIRPEMLAATLADLDVNVQVLEDQFLQDKDFLVGPHISLADVVAITELMHPVGGGCPVFEGRPRLAAWYRRVEAAVGKDLFLEAHEVILKVRDCPPADPVIKQKLMPRVLTMIQ", "length": 240 }, "evidence": [ { "id": "Q2NL00", "url": "https://omabrowser.org/oma/group/Q2NL00/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q64471-1", "protein_name": "Glutathione S-transferase theta-1", "gene_name": "Gstt1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVLELYLDLLSQPCRAIYIFAKKNNIPFQMHTVELRKGEHLSDAFARVNPMKRVPAMMDGGFTLCESVAILLYLAHKYKVPDHWYPQDLQARARVDEYLAWQHTGLRRSCLRALWHKVMFPVFLGEQIPPETLAATLAELDVNLQVLEDKFLQDKDFLVGPHISLADLVAITELMHPVGGGCPVFEGHPRLAAWYQRVEAAVGKDLFREAHEVILKVKDCPPADLIIKQKLMPRVLAMIQ", "length": 240 }, "evidence": [ { "id": "Q2NL00", "url": "https://omabrowser.org/oma/group/Q2NL00/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9ZRT5-1", "protein_name": "Glutathione S-transferase T1", "gene_name": "GSTT1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MMKLKVYADRMSQPSRAVIIFCKVNGIQFDEVLISLAKRQQLSPEFKDINPLGKVPAIVDGRLKLFESHAILIYLSSAFPSVADHWYPNDLSKRAKIHSVLDWHHTNLRRGAAGYVLNSVLGPALGLPLNPKAAAEAEQLLTKSLSTLETFWLKGNAKFLLGSNQPSIADLSLVCELMQLQVLDDKDRLRLLSTHKKVEQWIENTKKATMPHFDETHEILFKVKEGFQKRREMGTLSKPGLQSKI", "length": 245 }, "evidence": [ { "id": "Q2NL00", "url": "https://omabrowser.org/oma/group/Q2NL00/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "glutathione transferase activity", "id": "GO:0004364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004364", "evidence": [ { "database": "UniProtKB", "id": "Q2NL00", "url": "https://www.uniprot.org/uniprotkb/Q2NL00" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2NL00", "url": "https://www.uniprot.org/uniprotkb/Q2NL00" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2NL00", "url": "https://www.uniprot.org/uniprotkb/Q2NL00" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "glutathione metabolic process", "id": "GO:0006749", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006749", "evidence": [ { "database": "UniProtKB", "id": "Q2NL00", "url": "https://www.uniprot.org/uniprotkb/Q2NL00" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16437", "name": "", "equation": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O18879-1", "F1MUX5-1", "F1MX44-1", "A0ABI0P5M0-1", "A0AAA9TW47-1", "F6QEM8-1", "A0ABI0P3R2-1", "A0AAF6Z0W3-1", "P28801-1", "Q2KJG4-1", "A0A3Q1LMV5-1", "F1MVX2-1", "Q28035-1", "Q9N0V4-1", "Q2NL00-1", "F1MXY2-1", "E1BED9-1", "A0ABI0P006-1", "Q5E9G0-1", "Q64L89-1", "A0A452DIU1-1", "F1MGZ9-1", "A0AAA9TXU3-1", "E1BJX2-1" ], "evidence": [ { "id": "16437", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16437" } ] }, { "id": "R-BTA-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O18879-1", "E1BED9-1", "A0ABI0P006-1", "A0ABI0P5M0-1", "A0A3Q1LMV5-1", "F1MGZ9-1", "F1MUX5-1", "F1MX44-1", "Q2NL00-1", "Q5E9G0-1", "A0A452DIU1-1" ], "evidence": [ { "id": "R-BTA-176054", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176054" } ] }, { "id": "R-BTA-9753280", "name": "GSTs transfer GSH to NAPQI to form APAP-SG", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-9753466" ], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LMV5-1", "Q2NL00-1" ], "evidence": [ { "id": "R-BTA-9753280", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9753280" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-9753466", "participant_name": "NAPQI [cytosol]", "crossref": [ { "id": "173517", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LMV5", "gene_name": "LOC281806", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] } ] }, { "uniprot_ac": "A0A452DIU1", "gene_name": "LOC327709", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0A452DIU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DIU1" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0A452DIU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DIU1" } ] } ] }, { "uniprot_ac": "A0AAA9TW47", "gene_name": "GSTK1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0AAA9TW47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW47" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0AAA9TW47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW47" } ] } ] }, { "uniprot_ac": "A0AAA9TXU3", "gene_name": "GSTZ1", "activity": [ { "ec_number": "5.2.1.2", "activity": "4-maleylacetoacetate = 4-fumarylacetoacetate.", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] }, { "ec_number": "5.2.1.2", "activity": "", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] } ] }, { "uniprot_ac": "A0AAF6Z0W3", "gene_name": "LANCL1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0AAF6Z0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0AAF6Z0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ] } ] }, { "uniprot_ac": "A0ABI0P006", "gene_name": "LOC785216", "activity": [ { "ec_number": "1.20.4.2", "activity": "methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O.", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "1.8.5.1", "activity": "L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate.", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "1.8.5.1", "activity": "", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "1.20.4.2", "activity": "", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] } ] }, { "uniprot_ac": "A0ABI0P3R2", "gene_name": "GSTT2", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0ABI0P3R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3R2" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0ABI0P3R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3R2" } ] }, { "ec_number": "4.1.1.84", "activity": "D-dopachrome + H(+) = 5,6-dihydroxyindole + CO2.", "evidence": [ { "id": "A0ABI0P3R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3R2" } ] }, { "ec_number": "4.1.1.84", "activity": "", "evidence": [ { "id": "A0ABI0P3R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3R2" } ] } ] }, { "uniprot_ac": "A0ABI0P5M0", "gene_name": "GSTA1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0ABI0P5M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5M0" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0ABI0P5M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5M0" } ] } ] }, { "uniprot_ac": "E1BED9", "gene_name": "GSTO2", "activity": [ { "ec_number": "1.20.4.2", "activity": "methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O.", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] }, { "ec_number": "1.8.5.1", "activity": "L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate.", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] }, { "ec_number": "1.20.4.2", "activity": "", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] }, { "ec_number": "1.8.5.1", "activity": "", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] } ] }, { "uniprot_ac": "E1BJX2", "gene_name": "GSTT4", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "E1BJX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJX2" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "E1BJX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJX2" } ] } ] }, { "uniprot_ac": "F1MGZ9", "gene_name": "HPGDS", "activity": [ { "ec_number": "5.3.99.2", "activity": "prostaglandin H2 = prostaglandin D2.", "evidence": [ { "id": "F1MGZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted 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"crossref": [ { "id": "Q2NL08", "url": "https://alphafold.ebi.ac.uk/entry/Q2NL08", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd17960", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17960", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18787", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18787", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508581", "url": "https://www.ncbi.nlm.nih.gov/gene/508581", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000629", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000629", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011545", "database": "InterPro", "categories": [ 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"http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24031", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00270", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00270", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13959", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13959", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039472", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2NL08", "url": "https://www.uniprot.org/uniprotkb/Q2NL08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NL08-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL08-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEHVTEGSWESLPVPLHPKVLSVLRELGFPYMTPVQSATIPLFMKNKDVAAEAVTGSGKTLAFVIPIEEILLRREEKFKKSQVGAIIITPTRELAVQIEEVLSHFTKPFPQFSQILWIGGRNPGEDVARFKELGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLEVLVLDEADRLLDMGFETSINTILEFLPKQRRTGLFSATQTQEVENLVRAGLRNPVRISVKEKGVAASSTQKTPSRLENHYMVCKADEKFNQLVHFLRNHKQEKHLVFFSTCACVEYYGKALETLVKGVKIMCIHGKMKYKRNKIFMEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVFLLPMEESYISFLAINQKCPLQEMKLQKNTADLLPKLKAMALGDRAVFEKGMKAFVSYVQAYAKHECNLIFRLKDLDFASLARGFALLRMPKMPELRGKQFPDFVPVDVNTDTIPFKDKIREKQRQKQLLEQQRKEKTENDGRRKFIKNKAWSKQKAKKEKKKKLTEKRKREEGSDVEDEDMEELLNDTRLLKKFKKGKITEEEFEKGLLTSGKRSTNKADLEISDLEDDC", "length": 601, "header": "sp|Q2NL08-1|DDX55_BOVIN Isoform 1 of ATP-dependent RNA helicase DDX55 OS=Bos taurus OX=9913 GN=DDX55 PE=2 SV=1 CANONICAL=Q2NL08-1" }, "isoforms": [ { "isoform_ac": "Q2NL08-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL08/entry#Q2NL08-1", "sequence": { "sequence": "MEHVTEGSWESLPVPLHPKVLSVLRELGFPYMTPVQSATIPLFMKNKDVAAEAVTGSGKTLAFVIPIEEILLRREEKFKKSQVGAIIITPTRELAVQIEEVLSHFTKPFPQFSQILWIGGRNPGEDVARFKELGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLEVLVLDEADRLLDMGFETSINTILEFLPKQRRTGLFSATQTQEVENLVRAGLRNPVRISVKEKGVAASSTQKTPSRLENHYMVCKADEKFNQLVHFLRNHKQEKHLVFFSTCACVEYYGKALETLVKGVKIMCIHGKMKYKRNKIFMEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVFLLPMEESYISFLAINQKCPLQEMKLQKNTADLLPKLKAMALGDRAVFEKGMKAFVSYVQAYAKHECNLIFRLKDLDFASLARGFALLRMPKMPELRGKQFPDFVPVDVNTDTIPFKDKIREKQRQKQLLEQQRKEKTENDGRRKFIKNKAWSKQKAKKEKKKKLTEKRKREEGSDVEDEDMEELLNDTRLLKKFKKGKITEEEFEKGLLTSGKRSTNKADLEISDLEDDC", "length": 601, "header": "sp|Q2NL08-1|DDX55_BOVIN Isoform 1 of ATP-dependent RNA helicase DDX55 OS=Bos taurus OX=9913 GN=DDX55 PE=2 SV=1 CANONICAL=Q2NL08-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 545, "end_pos": 545, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2NL08", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ], "site_lbl": "Ser545" }, { "start_pos": 595, "end_pos": 595, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2NL08", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ], "site_lbl": "Ser595" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:508581", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508581", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q2NL08", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q2NL08", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "database": "UniProtKB", "id": "Q2NL08", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ], "pmid": "" }, { "name": "large ribosomal subunit rRNA binding", "id": "GO:0070180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070180", "evidence": [ { "database": "UniProtKB", "id": "Q2NL08", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q2NL08", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q2NL08", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "maturation of LSU-rRNA", "id": "GO:0000470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000470", "evidence": [ { "database": "UniProtKB", "id": "Q2NL08", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 348, "end_pos": 350, "annotation": "n_glycosylation_sequon" }, { "start_pos": 557, "end_pos": 559, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] } ] }, { "uniprot_ac": "A0AAA9RXI8", "gene_name": "SPATA5", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] } ] }, { "uniprot_ac": "A0AAA9RXM7", "gene_name": "HLTF", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] } ] }, { "uniprot_ac": "A0AAA9S5G9", "gene_name": "RECQL", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] } ] }, { "uniprot_ac": "A0AAA9TT27", "gene_name": "ATRX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] } ] }, { "uniprot_ac": "A0AAA9TT64", "gene_name": "DNA2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] } ] }, { "uniprot_ac": "A0AAF6DLT1", "gene_name": "SUPV3L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YVB0", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] } ] }, { "uniprot_ac": "A0AAF6Z0E4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] } ] }, { "uniprot_ac": "A0AAF6Z0U5", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] } ] }, { "uniprot_ac": "A0AAF6Z733", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] } ] }, { "uniprot_ac": "A0ABI0NSA6", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] } ] }, { "uniprot_ac": "A0ABI0NX25", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": 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"activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": 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{ "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", 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{ "start_pos": 10, "end_pos": 10, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2NL13", "url": "https://www.uniprot.org/uniprotkb/Q2NL13" } ], "site_lbl": "Ser10" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504874", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504874", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q2NL13", "url": "https://www.uniprot.org/uniprotkb/Q2NL13" } ], "pmid": "" }, { "name": "TRAPPIII protein complex", "id": "GO:1990072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990072", "evidence": [ { "database": "UniProtKB", "id": "Q2NL13", "url": 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Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.", "evidence": [ { "database": "UniProtKB", "id": "Q2NL18", "url": "https://www.uniprot.org/uniprotkb/Q2NL18#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NL18", "url": "https://www.uniprot.org/uniprotkb/Q2NL18" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HEYL", "url": "https://www.uniprot.org/uniprotkb/Q2NL18", "locus": { "chromosome": "3", "start_pos": 106458224, "end_pos": 106442706, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008688", "url": "https://www.ensembl.org/id/ENSBTAG00000008688" } ] } } ], "crossref": [ { "id": "Q2NL18", "url": "https://alphafold.ebi.ac.uk/entry/Q2NL18", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008688", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008688", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11447", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11447", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538609", "url": "https://www.ncbi.nlm.nih.gov/gene/538609", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "AFPVWPW", "url": "https://omabrowser.org/oma/group/AFPVWPW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NL18", "url": "https://www.orthodb.org/?gene=Q2NL18", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10985", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10985", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07527", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07527", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005204852", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204852", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2NL18", "url": "https://www.uniprot.org/uniprotkb/Q2NL18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NL18-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL18-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NL18-2", "url": "https://www.uniprot.org/uniprotkb/Q2NL18-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRPREPSGSDSESDGPIDVGREGELSQMARPLSTPSPSQMQARKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPPGPLAFPAWPWSFFHSCPGLSAPSNQLAILGRVPGPMLPNASSLAYPIPGLRAAPLRRAAGTILPARRNLLPSRGASSTRRARPLERPAAPLPAAPSGRATRGSHMAPLLRSPSPVSPGMVGSPAYMAVPAPRPSSPGLAGRPAGAMLCRSWVSEITEVGAF", "length": 328, "header": "sp|Q2NL18-1|HEYL_BOVIN Isoform 1 of Hairy/enhancer-of-split related with YRPW motif-like protein OS=Bos taurus OX=9913 GN=HEYL PE=2 SV=3 CANONICAL=Q2NL18-1" }, "isoforms": [ { "isoform_ac": "Q2NL18-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL18/entry#Q2NL18-1", "sequence": { "sequence": "MKRPREPSGSDSESDGPIDVGREGELSQMARPLSTPSPSQMQARKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPPGPLAFPAWPWSFFHSCPGLSAPSNQLAILGRVPGPMLPNASSLAYPIPGLRAAPLRRAAGTILPARRNLLPSRGASSTRRARPLERPAAPLPAAPSGRATRGSHMAPLLRSPSPVSPGMVGSPAYMAVPAPRPSSPGLAGRPAGAMLCRSWVSEITEVGAF", "length": 328, "header": "sp|Q2NL18-1|HEYL_BOVIN Isoform 1 of Hairy/enhancer-of-split related with YRPW motif-like protein OS=Bos taurus OX=9913 GN=HEYL PE=2 SV=3 CANONICAL=Q2NL18-1" }, "locus": {} }, { "isoform_ac": "Q2NL18-2", "url": "https://www.uniprot.org/uniprotkb/Q2NL18/entry#Q2NL18-2", "sequence": { "sequence": "MARPLSTPSPSQMQARKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPPGPLAFPAWPWSFFHSCPGLSAPSNQLAILGRVPGPMLPNASSLAYPIPGLRAAPLRRAAGTILPARRNLLPSRGASSTRRARPLERPAAPLPAAPSGRATRGSHMAPLLRSPSPVSPGMVGSPAYMAVPAPRPSSPGLAGRPAGAMLCRSWVSEITEVGAF", "length": 300, "header": "sp|Q2NL18-2|HEYL_BOVIN Isoform 2 of Hairy/enhancer-of-split related with YRPW motif-like protein OS=Bos taurus OX=9913 GN=HEYL PE=2 SV=3 CANONICAL=Q2NL18-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 165, "start_aa": "Thr", "end_pos": 165, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr165", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 35, "start_aa": "Thr", "end_pos": 35, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr35", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q2NL18", "url": "https://www.uniprot.org/uniprotkb/Q2NL18" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2UGT4-1", "protein_name": "Hes related family bHLH transcription factor with YRPW motif like", "gene_name": "HEYL", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKRLCEESSSDTESDGTIDVGKEEEYSHIPRSVSPTTTSQIQARKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEILQMTVDHLKMLHATGGAGFLDARALAVDYRSIGFRECLTEVVRYLGVLEGQSTADPIRLRLLSHLNNYVAEMEPSPAAASLLPVQTWPWSFLHSPVPVPRREAAPAPLLVTASYPRLAARPAPVRRVPADMLPSHRGPLPGRMASSARRARGAPSASTAAAAPRMPSPSGAPRGGSAKGSPISALLFSPAGVPLPAAYAAPTVLGAAAQGPALRVGAARLCRSWATEIGAF", "length": 318 }, "evidence": [ { "id": "Q2NL18", "url": "https://omabrowser.org/oma/group/Q2NL18/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZIH3-1", "protein_name": "Hes-related family bHLH transcription factor with YRPW motif-like", "gene_name": "Heyl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKRPRAPSGSDGESDGPIDVGQENDLSQMARPLTTPSPSQMQARKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHASGGAGFFDARALAVDFRSIGFRECLTEVVRYLGVLEGPSSHADPVRIRLLSHLNSYAAEMEPSPTTTGALAFPVWPWSFLHSCPGLPSLSSQLAILGRVPGPVLPNVSSPPYPISALRSAPVHRVPGTIPPAQRNLLPSRGVTSSQRAHPPERPAAPPPTALGVRAARSIVPILPCSSPAAPGAGKSDDSASGSISSPSPLGPTGRPAGAVFYHSWVSEITEIGAF", "length": 326 }, "evidence": [ { "id": "Q2NL18", "url": "https://omabrowser.org/oma/group/Q2NL18/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9DBX7-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif-like protein", "gene_name": "Heyl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKRPRAPSGSDGESDGPIDVGQENDLSQMARPLTTPSPSQMQARKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHASGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSHADPVRIRLLSHLKSYAAEMEPSPTTTSALAFPVWPWSFLHSCPGLPSLNSQLAILGRVPGPVLPSISSPPYPISALRSAPVHRPAGTIPPTRRNLLPSRGVTSTQRAHLPERPAAPPPTALDARAARSIVPIPPCSPTTAPGAGKSDDNVSGSISSPCPSGPTGRPAGAVFYHSWVSEITEIGAF", "length": 326 }, "evidence": [ { "id": "Q2NL18", "url": "https://omabrowser.org/oma/group/Q2NL18/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NQ87-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif-like protein", "gene_name": "HEYL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKRPKEPSGSDGESDGPIDVGQEGQLSQMARPLSTPSSSQMQARKKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFFHSCPGLPALSNQLAILGRVPSPVLPGVSSPAYPIPALRTAPLRRATGIILPARRNVLPSRGASSTRRARPLERPATPVPVAPSSRAARSSHIAPLLQSSSPTPPGPTGSAAYVAVPTPNSSSPGPAGRPAGAMLYHSWVSEITEIGAF", "length": 328 }, "evidence": [ { "id": "Q2NL18", "url": "https://omabrowser.org/oma/group/Q2NL18/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "circulatory system development", "id": "GO:0072359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072359", "evidence": [ { "database": "UniProtKB", "id": "Q2NL18", "url": "https://www.uniprot.org/uniprotkb/Q2NL18" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q2NL18", "url": "https://www.uniprot.org/uniprotkb/Q2NL18" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q2NL18", "url": "https://www.uniprot.org/uniprotkb/Q2NL18" } ], "pmid": "" }, { "name": "Notch signaling pathway", "id": "GO:0007219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", "evidence": [ { "database": "UniProtKB", "id": "Q2NL18", "url": "https://www.uniprot.org/uniprotkb/Q2NL18" } ], "pmid": "" }, { "name": "anterior/posterior pattern specification", "id": "GO:0009952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009952", "evidence": [ { "database": "UniProtKB", "id": "Q2NL18", "url": "https://www.uniprot.org/uniprotkb/Q2NL18" } ], "pmid": "" }, { "name": "regulation of neurogenesis", "id": "GO:0050767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050767", "evidence": [ { "database": "UniProtKB", "id": "Q2NL18", "url": "https://www.uniprot.org/uniprotkb/Q2NL18" } ], "pmid": "" }, { "name": "anatomical structure morphogenesis", "id": "GO:0009653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009653", "evidence": [ { "database": "UniProtKB", "id": "Q2NL18", "url": "https://www.uniprot.org/uniprotkb/Q2NL18" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2NL18", "url": "https://www.uniprot.org/uniprotkb/Q2NL18" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "Q2NL18", "url": "https://www.uniprot.org/uniprotkb/Q2NL18" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q2NL18", "url": "https://www.uniprot.org/uniprotkb/Q2NL18" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q2NL18", "url": "https://www.uniprot.org/uniprotkb/Q2NL18" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" }, { "start_pos": 60, "end_pos": 62, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NL18-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 328, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NL18-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NL18" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2NL18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL18" }, { "id": "PRU00380", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00380" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Orange", "eco_id": "ECO_0000255", "start_pos": 116, "end_pos": 153, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2NL18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL18" }, { "id": "PRU00981", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00981" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "bHLH", "eco_id": "ECO_0000255", "start_pos": 43, "end_pos": 98, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 35, 165 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 206, "end_pos": 208 }, { "start_pos": 60, "end_pos": 62 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2NL26-1", "uniprot_ac": "Q2NL26", "uniprot_id": "TKTL1_BOVIN", "mass": { "chemical_mass": 64966.0, "monoisotopic_mass": 64966.0 }, "refseq": { "ac": "NP_001039437", "name": "transketolase-like protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039437" }, "gene_names": [ { "name": "TKTL1", "type": "recommended", "evidence": [ { "id": "Q2NL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL26" } ] }, { "name": "TKTL1", "type": "synonym", "evidence": [ { "id": "NP_001039437", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039437" } ] } ], "protein_names": [ { "name": "Transketolase-like protein 1", "type": "recommended", "evidence": [ { "id": "Q2NL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL26/entry#names_and_taxonomy" } ] }, { "name": "2.2.1.1", "type": "synonym", "evidence": [ { "id": "Q2NL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL26/entry#names_and_taxonomy" } ] }, { "name": "TK 2", "type": "synonym", "evidence": [ { "id": "NP_001039437", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039437" }, { "id": "Q2NL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL26/entry#names_and_taxonomy" } ] }, { "name": "Transketolase 2", "type": "synonym", "evidence": [ { "id": "Q2NL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL26/entry#names_and_taxonomy" } ] }, { "name": "transketolase 2", "type": "synonym", "evidence": [ { "id": "NP_001039437", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039437" } ] }, { "name": "transketolase-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001039437", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039437" } ] } ], "function": [ { "annotation": "Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (By similarity). Thus, catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate (By similarity). The phosphate group of the substrate plays a role in stabilizing the substrate-thiamine intermediate while preventing the formation of the reactive enamine intermediate (By similarity). Can also use fructose-6-phosphate as a ketose donor (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2NL26", "url": "https://www.uniprot.org/uniprotkb/Q2NL26#function" }, { "database": "UniProtKB", "id": "P51854", "url": "https://www.uniprot.org/uniprotkb/P51854#function" }, { "database": "UniProtKB", "id": "P29401", "url": "https://www.uniprot.org/uniprotkb/P29401#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NL26", "url": "https://www.uniprot.org/uniprotkb/Q2NL26" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TKTL1", "url": "https://www.uniprot.org/uniprotkb/Q2NL26", "locus": { "chromosome": "X", "start_pos": 37378203, "end_pos": 37349741, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020127", "url": "https://www.ensembl.org/id/ENSBTAG00000020127" } ] } } ], "crossref": [ { "id": "Q2NL26", "url": "https://alphafold.ebi.ac.uk/entry/Q2NL26", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020127", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020127", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02012", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02012", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07033", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07033", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507517", "url": "https://www.ncbi.nlm.nih.gov/gene/507517", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005474", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005474", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005475", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005475", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020826", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020826", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029061", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029061", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033248", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033248", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507517", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507517", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EWTTGNL", "url": "https://omabrowser.org/oma/group/EWTTGNL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NL26", "url": "https://www.orthodb.org/?gene=Q2NL26", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43195", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43195", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43195:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43195:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00456", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00456", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02779", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02779", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02780", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02780", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039437", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10508", "url": "https://www.rhea-db.org/rhea/10508", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2NL26", "url": "https://www.uniprot.org/uniprotkb/Q2NL26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NL26-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL26-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADAEASATMADEAKPDSKTLQILRDMANRLRIHSIRATCASSSGHPISCSSAAEIMSVLFFHVMRYKQADPKNPDNDRFILSKRLSFVDVATGWLGQGLGAACGMAYTGKYFDKASYRVFCLVGDVESWEGSVWEALAFASHYSLDNLVAIFDVNRLTHSTTLPLEHSIDVYQKRCEAFGWNTLVVDGRDVEALCQVFWQAAQMKNKPTAVVAKTFKGRGIPSVEDAENWHGKPMPKERADAIIKLIESQIETNKSLEPKAPIEDSPQINISVIEMTSPPDYEISDVIATRKACGLALAKLGHANDRVIVLDGDTKNSTFSDIFKREHPERFIECFIAEQNMVSVALGCVTRGRTVAFACTFAAFLTRAFDQIRMGGISQTNINLIGSHCGVSIGEDGPSQMALEDLAMFRAIPNCTIFYPSDAISTEHAVFLAANIKGMCYIRTSRPETAIIYTPQESFEIGQAKVIRQSVNDKITVVGAGITLHEALAAADDLSKQGISLRVIDLFTVKPLDAATIISNAKATGGQIITVEDHYPEGGIGEAVSAAVSMEPDIVVHHLAVSGIPRSGKPSDLLDMFGISSKHIIWAVERILMK", "length": 596, "header": "sp|Q2NL26-1|TKTL1_BOVIN Isoform 1 of Transketolase-like protein 1 OS=Bos taurus OX=9913 GN=TKTL1 PE=2 SV=1 CANONICAL=Q2NL26-1" }, "isoforms": [ { "isoform_ac": "Q2NL26-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL26/entry#Q2NL26-1", "sequence": { "sequence": "MADAEASATMADEAKPDSKTLQILRDMANRLRIHSIRATCASSSGHPISCSSAAEIMSVLFFHVMRYKQADPKNPDNDRFILSKRLSFVDVATGWLGQGLGAACGMAYTGKYFDKASYRVFCLVGDVESWEGSVWEALAFASHYSLDNLVAIFDVNRLTHSTTLPLEHSIDVYQKRCEAFGWNTLVVDGRDVEALCQVFWQAAQMKNKPTAVVAKTFKGRGIPSVEDAENWHGKPMPKERADAIIKLIESQIETNKSLEPKAPIEDSPQINISVIEMTSPPDYEISDVIATRKACGLALAKLGHANDRVIVLDGDTKNSTFSDIFKREHPERFIECFIAEQNMVSVALGCVTRGRTVAFACTFAAFLTRAFDQIRMGGISQTNINLIGSHCGVSIGEDGPSQMALEDLAMFRAIPNCTIFYPSDAISTEHAVFLAANIKGMCYIRTSRPETAIIYTPQESFEIGQAKVIRQSVNDKITVVGAGITLHEALAAADDLSKQGISLRVIDLFTVKPLDAATIISNAKATGGQIITVEDHYPEGGIGEAVSAAVSMEPDIVVHHLAVSGIPRSGKPSDLLDMFGISSKHIIWAVERILMK", "length": 596, "header": "sp|Q2NL26-1|TKTL1_BOVIN Isoform 1 of Transketolase-like protein 1 OS=Bos taurus OX=9913 GN=TKTL1 PE=2 SV=1 CANONICAL=Q2NL26-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:507517", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507517", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "I3L954-1", "protein_name": "transketolase", "gene_name": "TKTL1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MADAEASTAVAEEAKPDAKTLQVLRDLANRLRIQSIRATCASSSGHPTSCSSAAEIMSVLCFHVMKYKQTDPENPDNDRLVLSKRLSFVDVAIGWLGQGLGAACGMAYTGKYFDKASYRVFCLMGDGESSEGSVWEALAFASHYSLDNLVAVFDVNRLSHSGTLPLEHCIDVYQKRCEAFGWNTFVVDGRDVEALCQVFWQASQMKSKPTAVVAKTFKGRGVPSVEDAENWHGKPMPKERADAIIKLIESQIQTNRNLEPKPPVEDSPQINITDIEMTSPPAYKIGDVVATRKACGLALAKLGHANDRVIVLDGDTKNSTFSEIFKKEYPERFIECFIAEQNMVNVALGCATRDRTVAFVCTFAAFLTRAFDQIRVGAIAQTNINLVGSHCGVSVGEDGPSQMALEDLAMFRAIPNCTVFYPSDAVSTEHAVFLAANTKGICYIRTSRPESAVVYTPQESFQIGQAKVIRQSVNDKITVVGAGVTLHEALAAADELSKQDISVRVIDLFTVKPLDAATIISNAKATGGRIITVEDHYPEGGIGEAICAAVSMEPDILVHQLAVPGVPRSGKPSELLDVFGISARHIIVAVKCVLMN", "length": 596 }, "evidence": [ { "id": "Q2NL26", "url": "https://omabrowser.org/oma/group/Q2NL26/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P51854-3", "protein_name": "Transketolase-like protein 1", "gene_name": "TKTL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADAEARAEFPEEARPDRGTLQVLQDMASRLRIHSIRATCSTSSGHPTSCSSSSEIMSVLFFYIMRYKQSDPENPDNDRFVLAKRLSFVDVATGWLGQGLGVACGMAYTGKYFDRASYRVFCLMSDGESSEGSVWEAMAFASYYSLDNLVAIFDVNRLGHSGALPAEHCINIYQRRCEAFGWNTYVVDGRDVEALCQVFWQASQVKHKPTAVVAKTFKGRGTPSIEDAESWHAKPMPRERADAIIKLIESQIQTSRNLDPQPPIEDSPEVNITDVRMTSPPDYRVGDKIATRKACGLALAKLGYANNRVVVLDGDTRYSTFSEIFNKEYPERFIECFMAEQNMVSVALGCASRGRTIAFASTFAAFLTRAFDHIRIGGLAESNINIIGSHCGVSVGDDGASQMALEDIAMFRTIPKCTIFYPTDAVSTEHAVALAANAKGMCFIRTTRPETMVIYTPQERFEIGQAKVLRHCVSDKVTVIGAGITVYEALAAADELSKQDIFIRVIDLFTIKPLDVATIVSSAKATEGRIITVEDHYPQGGIGEAVCAAVSMDPDIQVHSLAVSGVPQSGKSEELLDMYGISARHIIVAVKCMLLN", "length": 596 }, "evidence": [ { "id": "Q2NL26", "url": "https://omabrowser.org/oma/group/Q2NL26/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q556J0-1", "protein_name": "Transketolase", "gene_name": "tkt-1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSNIDFKALERAANETRGLSMDAVAKAASGHLGLPLGSAEIGAALFGNSLIYNPKDTRWLNRDYFVLSAGHGSMFLYSWLHLSGYDVSIEDIKNFRQLNSKTPGHPKFHDTPGVEATTGPLGQGIANAVGIASACKMAAGKFNTEQHQIFNQKVVVLVGDGCLQEGISQEAISFAGHHRLDNLIVFYDSNDVTLDAMAIETQSEDAVKRFESVGFEVQLVLEGNNIGSLINAYQNAKHSKSGKPQIIICKTTIAKGIPEVAGTNKGHGEAGVKFIDSARKNLGLPEEKFFVSGETRQYFEQHEKQLEKLYQEWQATFAEWKSANPKLAQLLESAHEKHEAIDIMKQIPEFPTTPIIATRKAGSDVLQPISQYLPLSVSGSADLHGSTLNYIKEGRDFTPACPTGRNIKFGIREHAMGAMMNGIAYHGLFKVSGATFLVFSDYLRPAIRLAALSHLPVVYIFTHDSVGVGEDGPTHQPVETVSGLRMIPNLDVIRPADPEETAAAFSLAYARADGPTLLSLTRQNLPFLPGTAQKKREGTLRGGYIVVSETAPLRMILIATGSEVQHCVEAAKLLGDDIRVVSMPCTELFDRQSNEYKQSVLPSGCRNRIAMEAGVTSFWYKYVGLDGKVIGIDRFGMSAPGNAVMKQLGMTSENLVNISKQ", "length": 661 }, "evidence": [ { "id": "Q2NL26", "url": "https://omabrowser.org/oma/group/Q2NL26/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2NL26", "url": "https://www.uniprot.org/uniprotkb/Q2NL26" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q2NL26", "url": "https://www.uniprot.org/uniprotkb/Q2NL26" } ], "pmid": "" }, { "name": "thiamine pyrophosphate binding", "id": "GO:0030976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030976", "evidence": [ { "database": "UniProtKB", "id": "Q2NL26", "url": "https://www.uniprot.org/uniprotkb/Q2NL26" } ], "pmid": "" }, { "name": "transketolase activity", "id": "GO:0004802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004802", "evidence": [ { "database": "UniProtKB", "id": "Q2NL26", "url": "https://www.uniprot.org/uniprotkb/Q2NL26" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" }, { "start_pos": 271, "end_pos": 273, "annotation": "n_glycosylation_sequon" }, { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" }, { "start_pos": 416, "end_pos": 418, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10508", "name": "", "equation": "D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NL26-1", "Q2NKZ4-1", "Q6B855-1" ], "evidence": [ { "id": "10508", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10508" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q2NKZ4", "gene_name": "TKTL2", "activity": [ { "ec_number": "2.2.1.1", "activity": "D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate.", "evidence": [ { "id": "Q2NKZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4" } ] }, { "ec_number": "2.2.1.1", "activity": "", "evidence": [ { "id": "Q2NKZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ4" } ] } ] }, { "uniprot_ac": "Q2NL26", "gene_name": "TKTL1", "activity": [ { "ec_number": "2.2.1.1", "activity": "D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate.", "evidence": [ { "id": "Q2NL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL26" } ] }, { "ec_number": "2.2.1.1", "activity": "", "evidence": [ { "id": "Q2NL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL26" } ] } ] }, { "uniprot_ac": "Q6B855", "gene_name": "TKT", "activity": [ { "ec_number": "2.2.1.1", "activity": "D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate.", "evidence": [ { "id": "Q6B855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6B855" } ] }, { "ec_number": "2.2.1.1", "activity": "", "evidence": [ { "id": "Q6B855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6B855" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NL26-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 596, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NL26-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NL26" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q2NL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL26#function" }, { "id": "Q2NL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL26" } ], "binding_site_uniprot": 126, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 126, "end_pos": 126, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2NL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL26#function" }, { "id": "Q2NL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL26" } ], "binding_site_uniprot": 156, "amino_acid": "Asn", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 156, "end_pos": 156, "start_aa": "Asn", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2NL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL26#function" }, { "id": "Q2NL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL26" } ], "binding_site_uniprot": 158, "amino_acid": "Leu", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 158, "end_pos": 158, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.2.1.1", "ec_name": "D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate.", "evidence": [ { "id": "2.2.1.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.2.1.1" }, { "id": "2.2.1.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.2.1.1" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], 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] } } ], "crossref": [ { "id": "Q2NL33", "url": "https://alphafold.ebi.ac.uk/entry/Q2NL33", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03593", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03593", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616085", "url": "https://www.ncbi.nlm.nih.gov/gene/616085", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013600", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013600", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ 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"header": "sp|Q2NL33-1|CL12B_BOVIN Isoform 1 of C-type lectin domain family 12 member B OS=Bos taurus OX=9913 GN=CLEC12B PE=2 SV=1 CANONICAL=Q2NL33-1" }, "isoforms": [ { "isoform_ac": "Q2NL33-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL33/entry#Q2NL33-1", "sequence": { "sequence": "MSEDMTYATLTFQDSVAAGNNQDRNNLRKRGYPAPSSIWRQAALGLLTLCVMLLIGLVTLGIMFLQMSSEINSDSDKLTQLQKIIHQQQDNISQQLSKYRNFPVEEEFLKSQISSLLKRQGQMAIKLCQELIIHTSDHKCNPCPKTWKWYQTSCYYFAVNEEKTWPNSRKNCMDKNSTLVKIDSLEEKDFLRSQPLPKFPFFWLGLSWDPSGRSWLWEDSSRPSPSLFSAYEYAQINESKGCAYFQNGNIYISRCSAEISWICEKTAALVKIEDLD", "length": 276, "header": "sp|Q2NL33-1|CL12B_BOVIN Isoform 1 of C-type lectin domain family 12 member B OS=Bos taurus OX=9913 GN=CLEC12B PE=2 SV=1 CANONICAL=Q2NL33-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 176, "start_aa": "Asn", "end_pos": 176, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn176", "evidence": [ { "id": "Q2NL33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL33#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 237, "start_aa": "Asn", "end_pos": 237, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn237", "evidence": [ { "id": "Q2NL33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL33#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": 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"GO:0002769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002769", "evidence": [ { "database": "UniProtKB", "id": "Q2NL33", "url": "https://www.uniprot.org/uniprotkb/Q2NL33" } ], "pmid": "" }, { "name": "melanocyte proliferation", "id": "GO:0097325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097325", "evidence": [ { "database": "UniProtKB", "id": "Q2NL33", "url": "https://www.uniprot.org/uniprotkb/Q2NL33" } ], "pmid": "" }, { "name": "negative regulation of receptor signaling pathway via STAT", "id": "GO:1904893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904893", "evidence": [ { "database": "UniProtKB", "id": "Q2NL33", "url": "https://www.uniprot.org/uniprotkb/Q2NL33" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "Q2NL33", "url": "https://www.uniprot.org/uniprotkb/Q2NL33" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "Q2NL33", "url": "https://www.uniprot.org/uniprotkb/Q2NL33" } ], "pmid": "" }, { "name": "protein phosphatase binding", "id": "GO:0019903", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019903", "evidence": [ { "database": "UniProtKB", "id": "Q2NL33", "url": "https://www.uniprot.org/uniprotkb/Q2NL33" } ], "pmid": "" }, { "name": "signaling receptor regulator activity", "id": "GO:0030545", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030545", "evidence": [ { "database": "UniProtKB", "id": "Q2NL33", "url": "https://www.uniprot.org/uniprotkb/Q2NL33" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 237, "end_pos": 239, "annotation": 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"table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2NL34-1", "uniprot_ac": "Q2NL34", "uniprot_id": "COQ9_BOVIN", "mass": { "chemical_mass": 35778.0, "monoisotopic_mass": 35778.0 }, "refseq": { "ac": "NP_001039767", "name": "ubiquinone biosynthesis protein COQ9, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039767" }, "gene_names": [ { "name": "COQ9", "type": "recommended", "evidence": [ { "id": "Q2NL34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL34" } ] }, { "name": "COQ9", "type": "synonym", "evidence": [ { "id": "NP_001039767", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039767" } ] } ], "protein_names": [ { "name": "Ubiquinone biosynthesis protein COQ9, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q2NL34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL34/entry#names_and_taxonomy" } ] }, { "name": "coenzyme Q9 homolog", "type": "synonym", "evidence": [ { "id": "NP_001039767", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039767" } ] }, { "name": "ubiquinone biosynthesis protein COQ9, mitochondrial precursor", "type": "synonym", "evidence": [ { "id": "NP_001039767", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039767" } ] }, { "name": "ubiquinone biosynthesis protein COQ9, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001039767", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039767" } ] } ], "function": [ { "annotation": "Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to COQ7, therefore facilitating the COQ7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.", "evidence": [ { "database": "UniProtKB", "id": "Q2NL34", "url": "https://www.uniprot.org/uniprotkb/Q2NL34#function" }, { "database": "UniProtKB", "id": "O75208", "url": "https://www.uniprot.org/uniprotkb/O75208#function" } ] }, { "annotation": "Missense mutation at position 159 (G-->A; rs109301586) associated with altered mitochondrial function and modulates reproductive function", "evidence": [ { "database": "RefSeq", "id": "NP_001039767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039767" }, { "database": "PubMed", "id": "28339599", "url": "https://glygen.org/publication/PubMed/28339599" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2NL34", "url": "https://www.uniprot.org/uniprotkb/Q2NL34" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COQ9", "url": "https://www.uniprot.org/uniprotkb/Q2NL34", "locus": { "chromosome": "18", "start_pos": 25456211, "end_pos": 25444079, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001855", "url": "https://www.ensembl.org/id/ENSBTAG00000001855" } ] } } ], "crossref": [ { "id": "Q2NL34", "url": "https://alphafold.ebi.ac.uk/entry/Q2NL34", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001855", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001855", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "529282", "url": "https://www.ncbi.nlm.nih.gov/gene/529282", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012762", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012762", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013718", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013718", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529282", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529282", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CAGFGWN", "url": "https://omabrowser.org/oma/group/CAGFGWN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2NL34", "url": "https://www.orthodb.org/?gene=Q2NL34", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21427", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21427", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21427:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21427:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08511", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08511", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21392", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21392", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2142789", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2142789", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039767", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2NL34", "url": "https://www.uniprot.org/uniprotkb/Q2NL34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2NL34-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL34-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAATVAFSGVLRRAGWRLLQLRCLPVPRCRPALAPRAFRASAMQLRSLDQQKDQPPPSSSQQQSEAQGAEEPNPEALRSPPRYTDQGGEEEEDYESEEQLQHRILTAALEFVPTHGWTAEAIAEGAQSLGLSSAAASMFGDDGSELILHFVTQCNARLTHVLEEEQKLVQLGQAEKKKTDKFLRDAVETRLRMLIPYIQHWPRAFSILMLPHNIPPSLNLLTSMVDDMWHYAGDQSTDFNWYTRRAVLAGIYNTTELVMMQDSSPDFEDTWRFLENRISDAMNMGHTAKQVKSTGEALVQGLMGAAVTLKNLTGLNQRR", "length": 319, "header": "sp|Q2NL34-1|COQ9_BOVIN Isoform 1 of Ubiquinone biosynthesis protein COQ9, mitochondrial OS=Bos taurus OX=9913 GN=COQ9 PE=2 SV=1 CANONICAL=Q2NL34-1" }, "isoforms": [ { "isoform_ac": "Q2NL34-1", "url": "https://www.uniprot.org/uniprotkb/Q2NL34/entry#Q2NL34-1", "sequence": { "sequence": "MAATVAFSGVLRRAGWRLLQLRCLPVPRCRPALAPRAFRASAMQLRSLDQQKDQPPPSSSQQQSEAQGAEEPNPEALRSPPRYTDQGGEEEEDYESEEQLQHRILTAALEFVPTHGWTAEAIAEGAQSLGLSSAAASMFGDDGSELILHFVTQCNARLTHVLEEEQKLVQLGQAEKKKTDKFLRDAVETRLRMLIPYIQHWPRAFSILMLPHNIPPSLNLLTSMVDDMWHYAGDQSTDFNWYTRRAVLAGIYNTTELVMMQDSSPDFEDTWRFLENRISDAMNMGHTAKQVKSTGEALVQGLMGAAVTLKNLTGLNQRR", "length": 319, "header": "sp|Q2NL34-1|COQ9_BOVIN Isoform 1 of Ubiquinone biosynthesis protein COQ9, mitochondrial OS=Bos taurus OX=9913 GN=COQ9 PE=2 SV=1 CANONICAL=Q2NL34-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "evidence": [ { "id": "28100784", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28100784" }, { "id": "Q2NL34", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q2NL34" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Mitochondrial O-GlcNAc Transferase (mOGT) Regulates Mitochondrial Structure, Function, and Survival in HeLa Cells.", "journal": "The Journal of biological chemistry", "date": "2017", "authors": "Sacoman JL, Dagda RY, Burnham-Marusich AR, Dagda RK, Berninsone PM", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q2NL34", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q2NL34" } ], "reference": [ { "type": "PubMed", "id": "28100784", "url": "https://glygen.org/publication/PubMed/28100784" } ] }, { "title": "A single nucleotide polymorphism in COQ9 affects mitochondrial and ovarian function and fertility in Holstein cows.", "journal": "Biology of reproduction", "date": "2017-03-01", "authors": "Ortega M Sofia, Wohlgemuth Stephanie, Tribulo Paula, Siqueira Luiz G B, Cole John B, Hansen Peter J", "evidence": [ { "database": "RefSeq", "id": "NP_001039767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039767" } ], "reference": [ { "type": "PubMed", "id": "28339599", "url": "https://glygen.org/publication/PubMed/28339599" } ] } ], "pathway": [ { "id": "bta:529282", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529282", "resource": "KEGG Pathway" }, { "id": "R-BTA-2142789", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2142789", "resource": "Reactome", "description": "Ubiquinol biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "F4IE14-1", "protein_name": "Ubiquinone biosynthesis protein", "gene_name": "COQ9", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MYRTAAKRLLAGGGITTTRLLRLPKLRSTIIPSSYTSGLCTSSIGGNTESPMGKQSVNPNQSGPTASSSTGTGEGQRRHESRKPRAEFQEEQARVLSASLRHVPRLGWTEEAMMAGSRDVGVSPSIVGSFSRKEAALVEFFMDECLQLLMDRIDSGLDLQNLIPSERISKLIRIRLEMQVPYMSKWPQALSIQAHPLNVPTSFKQRAMLVDEIWHAVGDGASDLDWYVKRTILGGVYSTTEIYMLTDDSLAEHRDTWAFLDDRVKDAFDLKKSIQEAKYFAEDIGAGVGKSVQGLMNGVMQTMSRRSGGSAF", "length": 312 }, "evidence": [ { "id": "Q2NL34", "url": "https://omabrowser.org/oma/group/Q2NL34/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "O75208-1", "protein_name": "Ubiquinone biosynthesis protein COQ9, mitochondrial", "gene_name": "COQ9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAAVSGALGRAGWRLLQLRCLPVARCRQALVPRAFHASAVGLRSSDEQKQQPPNSFSQQHSETQGAEKPDPESSHSPPRYTDQGGEEEEDYESEEQLQHRILTAALEFVPAHGWTAEAIAEGAQSLGLSSAAASMFGKDGSELILHFVTQCNTRLTRVLEEEQKLVQLGQAEKRKTDQFLRDAVETRLRMLIPYIEHWPRALSILMLPHNIPSSLSLLTSMVDDMWHYAGDQSTDFNWYTRRAMLAAIYNTTELVMMQDSSPDFEDTWRFLENRVNDAMNMGHTAKQVKSTGEALVQGLMGAAVTLKNLTGLNQRR", "length": 318 }, "evidence": [ { "id": "Q2NL34", "url": "https://omabrowser.org/oma/group/Q2NL34/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q68FT1-1", "protein_name": "Ubiquinone biosynthesis protein COQ9, mitochondrial", "gene_name": "Coq9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAATAAVSGVLRRLGWRLLQLRCLPVARCQSPLMPRAFHTAVGFRSSEEQRQQPPHSSQQHSETQGPEFSRPPPRYTDQSGEEEEDYESEEQIQHRILTAALEFVPDHGWTAEAIAEGAQSLGLSSAAASMFGSDGSELILHFVTQCNARLNHVLEEEQKLVQLGQAEKRKTDQFLRDAVETRLRMLIPYIEHWPRALSILLLPQNIPPSLSLLTSMVDDMWHYAGDQSTDFNWYTRRAVLAGIYNTTELVMMQDSSPDFEDTWRFLDNRINDAMNMGHTAKQVKSTGEALVQGLMGAAVTLKNLTGLNQRR", "length": 312 }, "evidence": [ { "id": "Q2NL34", "url": "https://omabrowser.org/oma/group/Q2NL34/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8K1Z0-1", "protein_name": "Ubiquinone biosynthesis protein COQ9, mitochondrial", "gene_name": "Coq9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAATAAVSGVLGRLGWRLLQLRCLPVARCRPALVPRAFHTAVGFRSSEEQKQQPPHSSSQQHSETQGPEFSRPPPRYTDQSGEEEEDYESEEQLQHRILTAALEFVPAHGWTAEAIAEGAQSLGLSSAAASMFGSDGSELILHFVTQCNARLNQVLEEEQKLVQLGQAEKRKTDQFLRDAVETRLRMLIPYIEHWPRALSILLLPHNIPPSLNLLTSMVDDMWHYAGDQSTDFNWYTRRAVLAGIYNTTELVMMQDSSPDFEDTWRFLENRINDAMNMGHTAKQVKSTGEALVQGLMGAAVTLKNLTGLNQRR", "length": 313 }, "evidence": [ { "id": "Q2NL34", "url": "https://omabrowser.org/oma/group/Q2NL34/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q2NL34", "url": "https://www.uniprot.org/uniprotkb/Q2NL34" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q2NL34", "url": "https://www.uniprot.org/uniprotkb/Q2NL34" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "Q2NL34", "url": "https://www.uniprot.org/uniprotkb/Q2NL34" } ], "pmid": "" }, { "name": "isoprenoid binding", "id": "GO:0019840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019840", "evidence": [ { "database": "UniProtKB", "id": "Q2NL34", "url": "https://www.uniprot.org/uniprotkb/Q2NL34" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ubiquinone biosynthetic process", "id": "GO:0006744", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006744", "evidence": [ { "database": "UniProtKB", "id": "Q2NL34", "url": "https://www.uniprot.org/uniprotkb/Q2NL34" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2NL34-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 319, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2NL34-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2NL34" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2NL34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL34" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "SIFI-degron", "eco_id": "ECO_0000250", "start_pos": 17, "end_pos": 32, "start_aa": "Arg", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 253, "end_pos": 255 }, { "start_pos": 311, "end_pos": 313 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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[ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2QDE9-1", "uniprot_ac": "Q2QDE9", "uniprot_id": "DNSL1_BOVIN", "mass": { "chemical_mass": 35168.0, "monoisotopic_mass": 35168.0 }, "refseq": { "ac": "NP_001033723", "name": "deoxyribonuclease-1-like 1 precursor", "summary": "This gene encodes a member of the deoxyribonuclease family and the protein shows high sequence similarity to lysosomal DNase I. In contrast to the human and mouse orthologs, porcine and bovine mRNAs for this gene use a conserved CUG triplet for translation initiation. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033723" }, "gene_names": [ { "name": "DNASE1L1", "type": "recommended", "evidence": [ { "id": "Q2QDE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2QDE9" } ] }, { "name": "DNASE1L1", "type": "synonym", "evidence": [ { "id": "NP_001033723", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033723" } ] } ], "protein_names": [ { "name": "Deoxyribonuclease-1-like 1", "type": "recommended", "evidence": [ { "id": "Q2QDE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2QDE9/entry#names_and_taxonomy" } ] }, { "name": "3.1.21.-", "type": "synonym", "evidence": [ { "id": "Q2QDE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2QDE9/entry#names_and_taxonomy" } ] }, { "name": "DNase I-like 1", "type": "synonym", "evidence": [ { "id": "NP_001033723", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033723" }, { "id": "Q2QDE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2QDE9/entry#names_and_taxonomy" } ] }, { "name": "DNase X", "type": "synonym", "evidence": [ { "id": "NP_001033723", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033723" }, { "id": "Q2QDE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2QDE9/entry#names_and_taxonomy" } ] }, { "name": "Deoxyribonuclease I-like 1", "type": "synonym", "evidence": [ { "id": "Q2QDE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2QDE9/entry#names_and_taxonomy" } ] }, { "name": "deoxyribonuclease I-like 1", "type": "synonym", "evidence": [ { "id": "NP_001033723", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033723" } ] }, { "name": "deoxyribonuclease-1-like 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001033723", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033723" } ] } ], "function": [ { "annotation": "Interestingly, the translation of porcine and bovine DNase X proteins occurs in the absence of an in-frame AUG initiation codon GeneRIF: replacement of proposed downstream alternate translation initiation triplet CTG with TTT, which has no potential for translation initiation, resulted in no protein synthesis", "evidence": [ { "database": "RefSeq", "id": "NP_001033723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033723" }, { "database": "PubMed", "id": "16107205", "url": "https://glygen.org/publication/PubMed/16107205" } ] }, { "annotation": "Results suggested that His44 may play a critical role in substrate DNA binding in this putative secondary active site.", "evidence": [ { "database": "RefSeq", "id": "NP_001033723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033723" }, { "database": "PubMed", "id": "18680463", "url": "https://glygen.org/publication/PubMed/18680463" } ] }, { "annotation": "This gene encodes a member of the deoxyribonuclease family and the protein shows high sequence similarity to lysosomal DNase I. In contrast to the human and mouse orthologs, porcine and bovine mRNAs for this gene use a conserved CUG triplet for translation initiation. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001033723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033723" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2QDE9", "url": "https://www.uniprot.org/uniprotkb/Q2QDE9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNASE1L1", "url": "https://www.uniprot.org/uniprotkb/Q2QDE9", "locus": { "chromosome": "X", "start_pos": 37454318, "end_pos": 37462057, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007455", "url": "https://www.ensembl.org/id/ENSBTAG00000007455" } ] } } ], "crossref": [ { "id": "Q2QDE9", "url": "https://alphafold.ebi.ac.uk/entry/Q2QDE9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd10282", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10282", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515176", "url": "https://www.ncbi.nlm.nih.gov/gene/515176", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036691", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515176", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515176", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2QDE9", "url": "https://www.orthodb.org/?gene=Q2QDE9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11371", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11371", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11371:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11371:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03372", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03372", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033723", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2QDE9", "url": "https://www.uniprot.org/uniprotkb/Q2QDE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2QDE9-1", "url": "https://www.uniprot.org/uniprotkb/Q2QDE9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHSSGGFQKAIHGHALLLLLLLASGAETFRICAFNAQRLTLAKVAREPVLDTLVKILARCDIMVLQEVVDSSDTAIPLLLRELNRFGDSGPYASHSSLLLGRSTYKEKYVYLYRSHEAEVRDSYMYDDQDDLFTREPFVCWFSLRSKVLPSLVLVPLHTTPKAVETELNALYDVFLDASGRWQTKDVILLGDFNADCTSLTKKRLDDLVLRTQAGFHWAIADGVDTTVRASTHCTYDRIVLHGELLQSLLRGAAAFDFPQSFGLTEQEALNISDHYPVEVDLALSWAVHGVQPPCLATLWLSLLLPLLAPQLGLVA", "length": 316, "header": "sp|Q2QDE9-1|DNSL1_BOVIN Isoform 1 of Deoxyribonuclease-1-like 1 OS=Bos taurus OX=9913 GN=DNASE1L1 PE=2 SV=1 CANONICAL=Q2QDE9-1" }, "isoforms": [ { "isoform_ac": "Q2QDE9-1", "url": "https://www.uniprot.org/uniprotkb/Q2QDE9/entry#Q2QDE9-1", "sequence": { "sequence": "MHSSGGFQKAIHGHALLLLLLLASGAETFRICAFNAQRLTLAKVAREPVLDTLVKILARCDIMVLQEVVDSSDTAIPLLLRELNRFGDSGPYASHSSLLLGRSTYKEKYVYLYRSHEAEVRDSYMYDDQDDLFTREPFVCWFSLRSKVLPSLVLVPLHTTPKAVETELNALYDVFLDASGRWQTKDVILLGDFNADCTSLTKKRLDDLVLRTQAGFHWAIADGVDTTVRASTHCTYDRIVLHGELLQSLLRGAAAFDFPQSFGLTEQEALNISDHYPVEVDLALSWAVHGVQPPCLATLWLSLLLPLLAPQLGLVA", "length": 316, "header": "sp|Q2QDE9-1|DNSL1_BOVIN Isoform 1 of Deoxyribonuclease-1-like 1 OS=Bos taurus OX=9913 GN=DNASE1L1 PE=2 SV=1 CANONICAL=Q2QDE9-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 271, "start_aa": "Asn", "end_pos": 271, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn271", "evidence": [ { "id": "Q2QDE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2QDE9#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Physical and biochemical properties of mammalian DNase X proteins: non-AUG translation initiation of porcine and bovine mRNAs for DNase X.", "journal": "Biochem. J.", "date": "2005", "authors": "Shiokawa D, Shika Y, Saito K, Yamazaki K, Tanuma S", "evidence": [ { "database": "UniProtKB", "id": "Q2QDE9", "url": "https://www.uniprot.org/uniprotkb/Q2QDE9" }, { "database": "RefSeq", "id": "NP_001033723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033723" } ], "reference": [ { "type": "PubMed", "id": "16107205", "url": "https://glygen.org/publication/PubMed/16107205" } ] }, { "title": "Putative secondary active site of bovine pancreatic deoxyribonuclease I.", "journal": "Protein and peptide letters", "date": "2008", "authors": "Chen Wei-Jung, Huang Po-Tsang, Cheng Yu-Che, Liao Ta-Hsiu", "evidence": [ { "database": "RefSeq", "id": "NP_001033723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033723" } ], "reference": [ { "type": "PubMed", "id": "18680463", "url": "https://glygen.org/publication/PubMed/18680463" } ] } ], "pathway": [ { "id": "bta:515176", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515176", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q2QDE9", "url": "https://www.uniprot.org/uniprotkb/Q2QDE9" } ], "pmid": "" }, { "name": "deoxyribonuclease I activity", "id": "GO:0004530", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004530", "evidence": [ { "database": "UniProtKB", "id": "Q2QDE9", "url": "https://www.uniprot.org/uniprotkb/Q2QDE9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2QDE9", "url": "https://www.uniprot.org/uniprotkb/Q2QDE9" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q2QDE9", "url": "https://www.uniprot.org/uniprotkb/Q2QDE9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA catabolic process", "id": "GO:0006308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006308", "evidence": [ { "database": "UniProtKB", "id": "Q2QDE9", "url": "https://www.uniprot.org/uniprotkb/Q2QDE9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 271, "end_pos": 273, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2QDE9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 316, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2QDE9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2QDE9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 271 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 271, "end_pos": 273 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2T9L8-1", "uniprot_ac": "Q2T9L8", "uniprot_id": "SYMC_BOVIN", "mass": { "chemical_mass": 100634.0, "monoisotopic_mass": 100634.0 }, "refseq": { "ac": "NP_001033180", "name": "methionine--tRNA ligase, cytoplasmic", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033180" }, "gene_names": [ { "name": "MARS1", "type": "recommended", "evidence": [ { "id": "Q2T9L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8" } ] }, { "name": "MARS1", "type": "synonym", "evidence": [ { "id": "NP_001033180", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033180" } ] }, { "name": "MARS", "type": "synonym", "evidence": [ { "id": "NP_001033180", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033180" }, { "id": "Q2T9L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8" } ] } ], "protein_names": [ { "name": "Methionine--tRNA ligase, cytoplasmic", "type": "recommended", "evidence": [ { "id": "Q2T9L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8/entry#names_and_taxonomy" } ] }, { "name": "6.1.1.10", "type": "synonym", "evidence": [ { "id": "Q2T9L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8/entry#names_and_taxonomy" } ] }, { "name": "MetRS", "type": "synonym", "evidence": [ { "id": "Q2T9L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8/entry#names_and_taxonomy" } ] }, { "name": "Methionyl-tRNA synthetase", "type": "synonym", "evidence": [ { "id": "Q2T9L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8/entry#names_and_taxonomy" } ] }, { "name": "metRS", "type": "synonym", "evidence": [ { "id": "NP_001033180", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033180" } ] }, { "name": "methionine--tRNA ligase, cytoplasmic", "type": "synonym", "evidence": [ { "id": "NP_001033180", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033180" } ] }, { "name": "methionine-tRNA synthetase", "type": "synonym", "evidence": [ { "id": "NP_001033180", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033180" } ] }, { "name": "methionyl-tRNA synthetase, cytoplasmic", "type": "synonym", "evidence": [ { "id": "NP_001033180", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033180" } ] } ], "function": [ { "annotation": "Catalyzes the specific attachment of L-methionine to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus (By similarity). In addition, can prevent the misincorporation of homocysteine into tRNA and protein by catalyzing a tRNA-independent hydrolysis of the misactivated homocysteinyl-AMP intermediate. The homocysteinyl-AMP intermediate undergoes an intramolecular cyclization reaction in which the thiolate side chain of homocysteine displaces the AMP group, forming homocysteine-thiolactone and AMP (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2T9L8", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8#function" }, { "database": "UniProtKB", "id": "P56192", "url": "https://www.uniprot.org/uniprotkb/P56192#function" }, { "database": "UniProtKB", "id": "A0A9J7F5X6", "url": "https://www.uniprot.org/uniprotkb/A0A9J7F5X6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9L8", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MARS1", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8", "locus": { "chromosome": "5", "start_pos": 55960458, "end_pos": 55988248, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018405", "url": "https://www.ensembl.org/id/ENSBTAG00000018405" } ] } } ], "crossref": [ { "id": "Q2T9L8", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9L8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00814", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00814", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00939", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00939", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07957", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07957", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd10307", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10307", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512531", "url": "https://www.ncbi.nlm.nih.gov/gene/512531", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000738", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000738", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004046", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004046", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009068", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009068", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009080", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009080", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010987", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010987", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014758", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014758", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023458", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023458", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033911", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033911", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512531", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512531", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9L8", "url": "https://www.orthodb.org/?gene=Q2T9L8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45765", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45765", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45765:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45765:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00043", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00043", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00458", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00458", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09334", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09334", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18485", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18485", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19303", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19303", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033180", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13481", "url": "https://www.rhea-db.org/rhea/13481", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "83875", "url": "https://www.rhea-db.org/rhea/83875", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "83879", "url": "https://www.rhea-db.org/rhea/83879", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "83883", "url": "https://www.rhea-db.org/rhea/83883", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9L8", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9L8-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLFVSEGAPGSLPVLAAAGRAQGRAELLISTVGPEECVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGPVRRALTHIDHSLSRRSCPFLAGETESLADIVLWGALYPLLQDPSYLPEELGALHSWFQTLSSQEPCQRAAETVLKQQGVLALRPYLQKQPQPSSLEGRLVSNEPEEEELATLSEEEIAVAVAAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKAMEEGLTPQEICDKYHVIHADIYRWFNISFDFFGRTTTPQQTKITQDIFQRLLARGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAIELKKPQCKVCRSCPVVKSSQHLFLDLPKLAARVEEWLEKTLPGSDWTANARFIIRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWEKWWKNPEQVNLYQFMAKDNVPFHGIVFPSSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYNRPEGQDSAFSWTDMLFKNNSELLNNLGNFINRAGMFVSKFFGGFVPEMVLTSDDQRLLTHITLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGGEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILPTNFLCTLPAGHQIGTVSPLFQKLENDQIESLKQRFSGGQAKASPKTAAGLTTAGPQQIQALTEEVTKQGNIVRELKAQKADKNQIAAEVAKLLDLKKQLALAEGKPLETSKGKKKK", "length": 898, "header": "sp|Q2T9L8-1|SYMC_BOVIN Isoform 1 of Methionine--tRNA ligase, cytoplasmic OS=Bos taurus OX=9913 GN=MARS1 PE=2 SV=1 CANONICAL=Q2T9L8-1" }, "isoforms": [ { "isoform_ac": "Q2T9L8-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8/entry#Q2T9L8-1", "sequence": { "sequence": "MRLFVSEGAPGSLPVLAAAGRAQGRAELLISTVGPEECVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGPVRRALTHIDHSLSRRSCPFLAGETESLADIVLWGALYPLLQDPSYLPEELGALHSWFQTLSSQEPCQRAAETVLKQQGVLALRPYLQKQPQPSSLEGRLVSNEPEEEELATLSEEEIAVAVAAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKAMEEGLTPQEICDKYHVIHADIYRWFNISFDFFGRTTTPQQTKITQDIFQRLLARGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAIELKKPQCKVCRSCPVVKSSQHLFLDLPKLAARVEEWLEKTLPGSDWTANARFIIRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWEKWWKNPEQVNLYQFMAKDNVPFHGIVFPSSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYNRPEGQDSAFSWTDMLFKNNSELLNNLGNFINRAGMFVSKFFGGFVPEMVLTSDDQRLLTHITLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGGEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILPTNFLCTLPAGHQIGTVSPLFQKLENDQIESLKQRFSGGQAKASPKTAAGLTTAGPQQIQALTEEVTKQGNIVRELKAQKADKNQIAAEVAKLLDLKKQLALAEGKPLETSKGKKKK", "length": 898, "header": "sp|Q2T9L8-1|SYMC_BOVIN Isoform 1 of Methionine--tRNA ligase, cytoplasmic OS=Bos taurus OX=9913 GN=MARS1 PE=2 SV=1 CANONICAL=Q2T9L8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 825, "end_pos": 825, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9L8", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8" } ], "site_lbl": "Ser825" }, { "start_pos": 833, "end_pos": 833, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9L8", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8" } ], "site_lbl": "Thr833" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:512531", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512531", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q2T9L8", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8" } ], "pmid": "" }, { "name": "tRNA binding", "id": "GO:0000049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", "evidence": [ { "database": "UniProtKB", "id": "Q2T9L8", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8" } ], "pmid": "" }, { "name": "methionine-tRNA ligase activity", "id": "GO:0004825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004825", "evidence": [ { "database": "UniProtKB", "id": "Q2T9L8", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q2T9L8", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2T9L8", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8" } ], "pmid": "" }, { "name": "aminoacyl-tRNA synthetase multienzyme complex", "id": "GO:0017101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017101", "evidence": [ { "database": "UniProtKB", "id": "Q2T9L8", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "methionyl-tRNA aminoacylation", "id": "GO:0006431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006431", "evidence": [ { "database": "UniProtKB", "id": "Q2T9L8", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 348, "end_pos": 350, "annotation": "n_glycosylation_sequon" }, { "start_pos": 531, "end_pos": 533, "annotation": "n_glycosylation_sequon" }, { "start_pos": 574, "end_pos": 576, "annotation": "n_glycosylation_sequon" }, { "start_pos": 642, "end_pos": 644, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13481", "name": "", "equation": "tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A6H7E1-1", "F1MDW1-1", "Q2T9L8-1" ], "evidence": [ { "id": "13481", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13481" } ] }, { "id": "83875", "name": "", "equation": "L-homocysteine + ATP = L-homocysteine thiolactone + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2T9L8-1" ], "evidence": [ { "id": "83875", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/83875" } ] }, { "id": "83879", "name": "", "equation": "L-homocysteine + ATP + H(+) = L-homocysteinyl-AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2T9L8-1" ], "evidence": [ { "id": "83879", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/83879" } ] }, { "id": "83883", "name": "", "equation": "L-homocysteinyl-AMP = L-homocysteine thiolactone + AMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2T9L8-1" ], "evidence": [ { "id": "83883", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/83883" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A6H7E1", "gene_name": "MARS2", "activity": [ { "ec_number": "6.1.1.10", "activity": "tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate.", "evidence": [ { "id": "A6H7E1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7E1" } ] }, { "ec_number": "6.1.1.10", "activity": "", "evidence": [ { "id": "A6H7E1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7E1" } ] } ] }, { "uniprot_ac": "F1MDW1", "gene_name": "MARS1", "activity": [ { "ec_number": "6.1.1.10", "activity": "tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate.", "evidence": [ { "id": "F1MDW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDW1" } ] }, { "ec_number": "6.1.1.10", "activity": "", "evidence": [ { "id": "F1MDW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDW1" } ] } ] }, { "uniprot_ac": "Q2T9L8", "gene_name": "MARS1", "activity": [ { "ec_number": "6.1.1.10", "activity": "tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate.", "evidence": [ { "id": "Q2T9L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8" } ] }, { "ec_number": "6.1.1.10", "activity": "", "evidence": [ { "id": "Q2T9L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9L8" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9L8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 898, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9L8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9L8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.1.1.10", "ec_name": "tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate.", "evidence": [ { "id": "6.1.1.10", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.10" }, { "id": "6.1.1.10", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.1.1.10" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 825, 833 ], "sequon_annotation_sites": [ { "start_pos": 348, "end_pos": 350 }, { "start_pos": 531, "end_pos": 533 }, { "start_pos": 574, "end_pos": 576 }, { "start_pos": 642, "end_pos": 644 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9M4-1", "uniprot_ac": "Q2T9M4", "uniprot_id": "DRC7_BOVIN", "mass": { "chemical_mass": 103168.0, "monoisotopic_mass": 103168.0 }, "refseq": { "ac": "NP_001033120", "name": "dynein regulatory complex subunit 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033120" }, "gene_names": [ { "name": "DRC7", "type": "recommended", "evidence": [ { "id": "Q2T9M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9M4" } ] }, { "name": "CCDC135", "type": "synonym", "evidence": [ { "id": "NP_001033120", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033120" }, { "id": "Q2T9M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9M4" } ] }, { "name": "DRC7", "type": "synonym", "evidence": [ { "id": "NP_001033120", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033120" } ] } ], "protein_names": [ { "name": "Dynein regulatory complex subunit 7", "type": "recommended", "evidence": [ { "id": "Q2T9M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9M4/entry#names_and_taxonomy" } ] }, { "name": "Coiled-coil domain-containing protein 135", "type": "synonym", "evidence": [ { "id": "Q2T9M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9M4/entry#names_and_taxonomy" } ] }, { "name": "Coiled-coil domain-containing protein lobo homolog", "type": "synonym", "evidence": [ { "id": "Q2T9M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9M4/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain containing 135", "type": "synonym", "evidence": [ { "id": "NP_001033120", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033120" } ] }, { "name": "coiled-coil domain-containing protein 135", "type": "synonym", "evidence": [ { "id": "NP_001033120", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033120" } ] }, { "name": "coiled-coil domain-containing protein lobo homolog", "type": "synonym", "evidence": [ { "id": "NP_001033120", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033120" } ] }, { "name": "dynein regulatory complex subunit 7", "type": "synonym", "evidence": [ { "id": "NP_001033120", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033120" } ] } ], "function": [ { "annotation": "Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Involved in the regulation of flagellar motility (By similarity). Essential for male fertility, sperm head morphogenesis and sperm flagellum formation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2T9M4", "url": "https://www.uniprot.org/uniprotkb/Q2T9M4#function" }, { "database": "UniProtKB", "id": "A8JAM0", "url": "https://www.uniprot.org/uniprotkb/A8JAM0#function" }, { "database": "UniProtKB", "id": "Q6V3W6", "url": "https://www.uniprot.org/uniprotkb/Q6V3W6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9M4", "url": "https://www.uniprot.org/uniprotkb/Q2T9M4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DRC7", "url": "https://www.uniprot.org/uniprotkb/Q2T9M4", "locus": { "chromosome": "18", "start_pos": 25700260, "end_pos": 25679294, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008005", "url": "https://www.ensembl.org/id/ENSBTAG00000008005" } ] } } ], "crossref": [ { "id": "Q2T9M4", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9M4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008005", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008005", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504736", "url": "https://www.ncbi.nlm.nih.gov/gene/504736", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR033551", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033551", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056290", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056290", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056292", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056292", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504736", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504736", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CRDDYIT", "url": "https://omabrowser.org/oma/group/CRDDYIT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2T9M4", "url": "https://www.orthodb.org/?gene=Q2T9M4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35249", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35249", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35249:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35249:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF24656", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24656", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24667", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24667", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24671", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24671", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033120", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9M4", "url": "https://www.uniprot.org/uniprotkb/Q2T9M4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9M4-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9M4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVLKEKVEEEEAAEREEAAERAERGEKTKRPMEVRREETTMTQEMLRDLERKLSEIEVSVPEKLLAFTKDTIDTSKLPLSYQSNTLKEEHLLQVADNFSRQYSHLCPDRVPLFLHPLNECEVPKFVSTTIRPTLMPYPELYNWDTCAQFISDFLSMVPLPDPLKPPLYLYSSTTVLKYQKGNCFDFSTLLCSMLIGAGYDAYCVNGYGSQDLCHMDLTREVCPLTMKPKESVKEEEKAPPKKYAIKPPRDLTSRFEQEQEMKRQEAIKAEEENRRKQEEARLLEQENAKTDPLHGLRVHSWVLVLSGKREVPESFFIDPFTARSYSTQDDHFLGIESLWNHKNYWVNMQDCWNCCKDLVFDLGDPVRWEYLLLGTDKPFLSLTEEEDEGMNDDDDVENLGKEDEDKSFDMPPSWVEQIEISPEAFETRCPNGKKVIQYKRAKLEKWAPYLNNNGLVCRLTTYEDLECTKTLEMKEWYQNREDMLELKHINKITGLNVDYFKPGHPQALRVHSYKSMQPEMDRVMEFYETARVDGLIKREETPKTMTEHYQGRPDFLSYRHVNFGPRMKKLALNSAESNPRPMVKITERFFRNPAKPADEDVAERVFLIAEERIQLRYHCRSDHITANKREFLRRTEVDSKGNKIIMTPDMCISFEVEPMEHTKKLLYQYEAMMKLKNEEKLSRHQAWESELEVLEILKLREEEEEAHTLTISIYDTKRNEKCKEYREAMERVLHEEHLRQVEAQLDYLAPFLAQLPPGEKLTRWQAVRLKDECLNDFKQRLIDKANLIQARFEKETQELQKKQQWYQENQVTLTPEDEDLYLSYCSQAMFRIRILEQRLSRHKELAPLKYLALEEKLYKDPRLVELLKVFV", "length": 872, "header": "sp|Q2T9M4-1|DRC7_BOVIN Isoform 1 of Dynein regulatory complex subunit 7 OS=Bos taurus OX=9913 GN=DRC7 PE=1 SV=1 CANONICAL=Q2T9M4-1" }, "isoforms": [ { "isoform_ac": "Q2T9M4-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9M4/entry#Q2T9M4-1", "sequence": { "sequence": "MEVLKEKVEEEEAAEREEAAERAERGEKTKRPMEVRREETTMTQEMLRDLERKLSEIEVSVPEKLLAFTKDTIDTSKLPLSYQSNTLKEEHLLQVADNFSRQYSHLCPDRVPLFLHPLNECEVPKFVSTTIRPTLMPYPELYNWDTCAQFISDFLSMVPLPDPLKPPLYLYSSTTVLKYQKGNCFDFSTLLCSMLIGAGYDAYCVNGYGSQDLCHMDLTREVCPLTMKPKESVKEEEKAPPKKYAIKPPRDLTSRFEQEQEMKRQEAIKAEEENRRKQEEARLLEQENAKTDPLHGLRVHSWVLVLSGKREVPESFFIDPFTARSYSTQDDHFLGIESLWNHKNYWVNMQDCWNCCKDLVFDLGDPVRWEYLLLGTDKPFLSLTEEEDEGMNDDDDVENLGKEDEDKSFDMPPSWVEQIEISPEAFETRCPNGKKVIQYKRAKLEKWAPYLNNNGLVCRLTTYEDLECTKTLEMKEWYQNREDMLELKHINKITGLNVDYFKPGHPQALRVHSYKSMQPEMDRVMEFYETARVDGLIKREETPKTMTEHYQGRPDFLSYRHVNFGPRMKKLALNSAESNPRPMVKITERFFRNPAKPADEDVAERVFLIAEERIQLRYHCRSDHITANKREFLRRTEVDSKGNKIIMTPDMCISFEVEPMEHTKKLLYQYEAMMKLKNEEKLSRHQAWESELEVLEILKLREEEEEAHTLTISIYDTKRNEKCKEYREAMERVLHEEHLRQVEAQLDYLAPFLAQLPPGEKLTRWQAVRLKDECLNDFKQRLIDKANLIQARFEKETQELQKKQQWYQENQVTLTPEDEDLYLSYCSQAMFRIRILEQRLSRHKELAPLKYLALEEKLYKDPRLVELLKVFV", "length": 872, "header": "sp|Q2T9M4-1|DRC7_BOVIN Isoform 1 of Dynein regulatory complex subunit 7 OS=Bos taurus OX=9913 GN=DRC7 PE=1 SV=1 CANONICAL=Q2T9M4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504736", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504736", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M9PYW2-1", "protein_name": "Dynein regulatory complex subunit 7 isoform X1", "gene_name": "ccdc135", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEVLPEMESEEDATLTDDEEKKGFRELESSLNNNIRLTPDLPHIMKPRTPVDLSRYPSSYKQNSSQETLMLAMAENFRQQFVLLYPDRKALLLSPVNECGVQKFVSTTLRSSLLPYPELYDWEGCASFVSDYLSLELLDPPFELPKQLSSPTRVLQTQRGTCFEFSMVLCSLLLGAGFNAYCVSGYATKEMCLLDQSRQECPLLKPPKQDNTEEPKKTVNKYSVKPPRDLYSTFEKHQEEKQQAKVKADAVKKQQEEERLRKEQERPPHDPLLGLRIHSWVLVLSGSREIPENFFIDPLTGKGYSTTNENFVGIESIWNHQNYWVNKQDCSFGCGSMTFDLGDLSKWEYMLCGLTSQSISMISEQKSPREPEDEEEEEIDELKAFEMPTSWVTKIDIPPPDMEMRYPGGSKILQYRKAKLEKFAPYLLKDGLVTKLTTYKDLECTQPNTIKEWFKHRSDHLEERELHTDSNVTTEHFRPGRSDALKYHRYVTLVPETERQMDFYGHTCTDGLARRIEKQSEMTETFEDRTDFLYYRHIVYGKQIKVIRAGEALNQRPIKSVEERFHRDPSKPASKDVAERNFKMSDGKIQVTYHLEDDRIIPAWMNFIKPKAAANSQKGQDFSPEMVSGFQVDPFAKPYNDLQLYKILLELMRDEENVELQIRNSEKEVKSILSSREKEDSNTDLLISIYNTTRNETARRHMEEKERKAKEKQKRQKEKELDLLAPFQARLEQTESLTLKDALQLKRDCLTEFKQQLANKANLIQGRFEKETEELQKKQLWYQKNQLTMSTEDEEDYFKYCSEAMFRIHVLKLRLSRQKERAPQRYLALEETLKRHPKLATDS", "length": 843 }, "evidence": [ { "id": "Q2T9M4", "url": "https://omabrowser.org/oma/group/Q2T9M4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZZ82-1", "protein_name": "Dynein regulatory complex subunit 7", "gene_name": "Drc7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEVLREKVEEEEEAEREEAAERAERAEKAERVLKATEVSKEGIILSQDDLRDLEEKLMAIEIPTPADHSVICQVPVDVTKLPPSYTTNSLKEEHLLLVADNFSRQYSHLCPDRVPLFLHPLNECNVPKFVSTTLRPTLMPYPELYNWDSCAQFVSDFLTMVPLVDPLKPPTHLYSSTTVLQCQKGNCFDFSTLLCSMLIGSGYDAYCVNGYGSLDLCLMDLTREVCPLTVKAKEIVAKKEKVAPKKYAVKPPRDLTSRFEQEQEEKRLQAIKDQELKRLKEEEERLLEAEKAKPDPLHGLRVHSWVLVLSGKREVPESFFIDPFTGRSYGTKDDHFLGIESLWNHKNYWINMQDCWNCCKDLIFDLGDPVRWEYMLLGTDKPHLSLTDDDDEGLDDDEDEDQGKEEEDKSFDMPPSWVAQIEITPEEFETRCPSGKKVIQYKKAQLEKWSPYLNNNGLVCRLTTYEDLQCTKVLEIKEWYQNREDMLELKHINKTTGLHVDYFKPGHPQALCVHSYKSMLPEMDRVMEFYKMIRVDGLVKREETPMTMTEYYQGRSDFLSYRHINFGPRVKKLTQNSADSNPRPVVKITEQFFRNPEKPADEDVAERVFLIAEERIQLRYHCRDDYITANKREFLRRTEVDSKGNKIIMTPEMCISYEVEPMEHTKKLLYQYETMIHLKNEEKLSRHQAWESELEVLEILKLREEEEEAHTLTISIYDTKRNEKSKEYREAMERVLHEEHLRQVEAQLDYLAPFLAQLPPGEKLTRWQAVRLKDECLSDFKQRLIDKANLIQARFEKETQELQKKQQWYQENQVTLTPEDEDLYLSYCSQAMFRIRILEQRLNRHKELAPLKYLALEEKLYKDPRLIDFVKGFV", "length": 874 }, "evidence": [ { "id": "Q2T9M4", "url": "https://omabrowser.org/oma/group/Q2T9M4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RF34-1", "protein_name": "Dynein regulatory complex subunit 7", "gene_name": "DRC7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEVLKEKVEEEEAAEREEAAERAERREKAMWPMEVQKEESTVTQEMLRDLERKLSEIEVSIPEKPSTFTNDPIDVSKLPLSYQSNTLKEEHLLQVADNFSRQYSHLCPDRVPLFLHPLNECKVPKFVSTTIRPTLMPYPELYNWDTCAQFVSDFLSMVPLPDPLKPPPYLYSSATVLKLQKGNCFDFSTLLCSMLIGAGYDAYCVNGYGSQELCLMDLTREVCPLTMKPKEAVQEEEKAPPKKYAIRPPRDLSSRFEQEQEMKRQKAIQAEEEQRLRQEEERLMEEESAKTDPLHGLRVHSWVLVLAGKREVPESFFIDPFTARSYGKDDDHFLGIESLWNHKNYWVNMQDCWNCCKDLVFDLGDPVKWEYMLLDTSKPLLSLTEGDDSEMSEMNDEDDVENLGKEDEDESFDMPPAWVERIEISPEAFETRCPNGKKVIQYKRAKLEKWAPYVNTNGLVSRLTSYEDLECTKILEVKEWFQNREDMLELRHVNKITGLIIDSFKPGHSQALRVHSYTSMQPERDRVMEFYETARVDGLIKREETAKTMTEYYQGRPDFLSYRHVDFGPRVKKTALNSAESNPRPVVKITERFLRNPEKPADEDVAERVFMILDERIQLRYHCREDHITASKREFLRRTEVDSKGNKIIMTPDMCISFEVEPTEHTKKLLYQYEAMMKLKDEEKLSRHQAWESELEVLEILKLREEEEAAHALTISIYDTKRNEKSKEYREAMERVMHEEHLRQMEAQLDYLAPFLAQLPPGEKLTRWQAVRLKDECLSDFKQRLIDKANLIQARFEKETQELQKKQQWYQENQVTLTPEDEDLYLSYCSQAMFRIRILEQRLNRHKELAPLKYLALEEKLYKDPRLVEILKVFV", "length": 875 }, "evidence": [ { "id": "Q2T9M4", "url": "https://omabrowser.org/oma/group/Q2T9M4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q4V516-1", "protein_name": "Coiled-coil domain-containing protein lobo", "gene_name": "lobo", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPKVLFQKYKKVVSNIDPSRYSAKFKEIDEQRRSQGSESDFADEMEGEFEAEMEEMGSSEFSLSEGEPSLNIGKIDLSFPETVEEFENSPQCYPPSYYTLSPKERLLLLYAENFRKQLVLSYPKRRAMVLALPNECKVQKFVCTTIRPTAFIYTQLISSVEEIAKFVADFIQYEPLQDPINLPNRLISPETLLRKRKGNSYEMATLLVSMLIGAGHPALVVSGVAREETILNDQLAVPYPYPIVEVEVEEVKPKVEKPGQKYKLRGLPDLKSHLEEDMAEVHRQKEAEEKRIQDEIIRKQMEDLELLAVDRYHYRRSHAWVVIINNAPWSVKPKTTYTDVNGDVVEAPPTAIFIEPSTGFICETGCKQYILVDSIWNEYNYYVCKQKHQRVSELRWDLRDTKDWEHMLPGEPPEMRIYKMASDENVADEERDISEEKHLDCIGSWVERLHIGLADFEQRFPSSEKKIQYKGAIHERFSPYSQRDGKVMQLTIFNNDECTIPKVRYEYYENRSDLMRHVKYTYATDQFEEIFNKGRNDSLKSIEYFSDPSQQRKVHFFSASRIDSLELMVVEPGSLILHYKDRSDKCWYKEFEFTPAGNVLKKVTEKFLKASANDVCSNDIATRTFLFQQNKIVLKFHYTFGALTATVVEFTKPPRPDYGKELIYDEKLTKIYKANPLDPTRTNLELYRLLCEQLQYEDHLRKNFEKIFEDINNVFDLRKSEKAEPKLKFSIFDPLRNGAARAIRMRQFEEEEELKKEIASKPADFLAPYLVPYKHQEELTPEQSQNAYNACLNDLKSRFVSLLNNLQRHYEDLTSESKSLNRFLNKFENQFNNYDYKRLVQQSKDLELNKRMVQQRLTLTHEESQKKYEVVKNSLLKDPRLNFKKDDLARRASETSK", "length": 897 }, "evidence": [ { "id": "Q2T9M4", "url": "https://omabrowser.org/oma/group/Q2T9M4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q6V3W6-1", "protein_name": "Dynein regulatory complex subunit 7", "gene_name": "Drc7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEVLREKVEEEEEAEREEAAERAERTEKLERVTKSAEVSREGTILSQDELRDLEGKLMAIEIPTQADHSVISQAPVDVTKLPPSYTTNSLKEEHLLLVADNFSRQYSHLCPDRVPLFLHPLNECNVPKFVSTTLRPTLMPYPELYNWDSCAQFVSDFLTMVPLVDPLKPPTHLYSSTTVLKCQKGNCFDFSTLLCSMLIGSGYDAYCVNGYGSLDLCLMDLTREVCPLTVKAKEIVKKKEKTVPKKYSIKPPRDLTSKFEQEQEEKRIQEIKDLEQRRLKEEEDRILEAEKAKPDPLHGLRVHSWVLVLAGKREVPESFFIDPLTARSYSTKDEHFLGIESLWNHKNYWINMQDCWNCCKDLIFDLGDPVRWEYMLLGTDKPHLSLTEEDEEGLDDDDDDVEDLGKEEEDKSFDMPSSWVSQIEITPEEFETRCPSGKKVIQYKKAQLEKWSPYLNNNGLVCRLTTYEDQQCTKVLEIKEWYQNREDMLELKHINKTTGLHVDYFKPGHPQALCVHSYKSMLPEMDRVMEFYKKIRVDGLVKREETPMTMTEYYEGRSDFLAYRHVNFGPRVKKLSQSSVESNPRPMVKITERFSRNPEKPADEDVAERLFLIVEERIQLRYHCRDDYITASKREFLRRMEVDSKGNKIIMTPEMCISYEVEPMEHTKKLLYQYETMNQLKNEEKLSRHQAWESELEVLEILKLREEEEEAHTLTISIYDTKRNEKSKEYREAMERVLHEEHLRQVEAQLDYLAPFLAQLPPGEKLTRWQAVRLKDECLSDFKQRLIDKANLIQARFEKETQELQKKQQWYQENQVTLTPEDENLYLSYCSQAMFRIRILEQRLNRHKELAPLKYLALEEKLYKDPRLIDFVKVFV", "length": 876 }, "evidence": [ { "id": "Q2T9M4", "url": "https://omabrowser.org/oma/group/Q2T9M4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IY82-1", "protein_name": "Dynein regulatory complex subunit 7", "gene_name": "DRC7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q2T9M4", "url": "https://www.uniprot.org/uniprotkb/Q2T9M4" } ], "pmid": "" }, { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "Q2T9M4", "url": "https://www.uniprot.org/uniprotkb/Q2T9M4" } ], "pmid": "" }, { "name": "sperm axoneme assembly", "id": "GO:0007288", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007288", "evidence": [ { "database": "UniProtKB", "id": "Q2T9M4", "url": "https://www.uniprot.org/uniprotkb/Q2T9M4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "Q2T9M4", "url": "https://www.uniprot.org/uniprotkb/Q2T9M4" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "Q2T9M4", "url": "https://www.uniprot.org/uniprotkb/Q2T9M4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 98, "end_pos": 100, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9M4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 872, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9M4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9M4" } ], "lectin_list": [], 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9P3-1", "uniprot_ac": "Q2T9P3", "uniprot_id": "RGP1_BOVIN", "mass": { "chemical_mass": 43098.0, "monoisotopic_mass": 43098.0 }, "refseq": {}, "gene_names": [ { "name": "RGP1", "type": "recommended", "evidence": [ { "id": "Q2T9P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P3" } ] } ], "protein_names": [ { "name": "RAB6A-GEF complex partner protein 2", "type": "recommended", "evidence": [ { "id": "Q2T9P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P3/entry#names_and_taxonomy" } ] }, { "name": "Retrograde Golgi transport protein RGP1 homolog", "type": "synonym", "evidence": [ { "id": "Q2T9P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9P3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors.", "evidence": [ { "database": "UniProtKB", "id": "Q2T9P3", "url": "https://www.uniprot.org/uniprotkb/Q2T9P3#function" }, { "database": "UniProtKB", "id": "Q92546", "url": "https://www.uniprot.org/uniprotkb/Q92546#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9P3", "url": "https://www.uniprot.org/uniprotkb/Q2T9P3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RGP1", "url": "https://www.uniprot.org/uniprotkb/Q2T9P3", "locus": { "chromosome": "8", "start_pos": 59922869, "end_pos": 59917005, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011433", "url": "https://www.ensembl.org/id/ENSBTAG00000011433" } ] } } ], "crossref": [ { "id": "Q2T9P3", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9P3", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR014848", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014848", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539393", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539393", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9P3", "url": "https://www.orthodb.org/?gene=Q2T9P3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12507", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12507", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08737", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08737", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q2T9P3", "url": "https://www.uniprot.org/uniprotkb/Q2T9P3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9P3-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9P3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIEVVAELSRGPVFLAGEALECVVTVTNPLPPTATSASSEALAWASAQIHCQFHASESRVALPPPDSSQPDVQPESQTVLLPHRGERGQCILSTPPKILFCDLRLDPGESKSYSYSEVLPVEGPPSFRGQSVKYVYKLTIGCQRVNSPITLLRVPLRVLVLTGLQDVRFPQDEAVAPSSPFLEEDEGGKKDSWLTELAGERLMAATSCRSLHLYNISDGRGKVGTFGIFKSVYRLGEDVVGTLNLGEGTVACLQYSVSLQTEERVQPEYQRRRGAGGAPSVSHITHARHQESCLHTTRTSFSLPIPLSSTPGFCTAIVSLKWRLHFEFVTSREPGLVLLPPVEQPEPATWTGPEQVPVDTFSWDLPIKPEASHTFLSVQPASYCYSVRSHIRAI", "length": 394, "header": "sp|Q2T9P3-1|RGP1_BOVIN Isoform 1 of RAB6A-GEF complex partner protein 2 OS=Bos taurus OX=9913 GN=RGP1 PE=2 SV=1 CANONICAL=Q2T9P3-1" }, "isoforms": [ { "isoform_ac": "Q2T9P3-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9P3/entry#Q2T9P3-1", "sequence": { "sequence": "MIEVVAELSRGPVFLAGEALECVVTVTNPLPPTATSASSEALAWASAQIHCQFHASESRVALPPPDSSQPDVQPESQTVLLPHRGERGQCILSTPPKILFCDLRLDPGESKSYSYSEVLPVEGPPSFRGQSVKYVYKLTIGCQRVNSPITLLRVPLRVLVLTGLQDVRFPQDEAVAPSSPFLEEDEGGKKDSWLTELAGERLMAATSCRSLHLYNISDGRGKVGTFGIFKSVYRLGEDVVGTLNLGEGTVACLQYSVSLQTEERVQPEYQRRRGAGGAPSVSHITHARHQESCLHTTRTSFSLPIPLSSTPGFCTAIVSLKWRLHFEFVTSREPGLVLLPPVEQPEPATWTGPEQVPVDTFSWDLPIKPEASHTFLSVQPASYCYSVRSHIRAI", "length": 394, "header": "sp|Q2T9P3-1|RGP1_BOVIN Isoform 1 of RAB6A-GEF complex partner protein 2 OS=Bos taurus OX=9913 GN=RGP1 PE=2 SV=1 CANONICAL=Q2T9P3-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 310, "start_aa": "Thr", "end_pos": 310, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr310", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539393", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539393", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "Ric1-Rgp1 guanyl-nucleotide exchange factor complex", "id": "GO:0034066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034066", "evidence": [ { "database": "UniProtKB", "id": "Q2T9P3", "url": "https://www.uniprot.org/uniprotkb/Q2T9P3" } ], "pmid": "" }, { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q2T9P3", "url": "https://www.uniprot.org/uniprotkb/Q2T9P3" } ], "pmid": "" }, { "name": "cytosol", "id": 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transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "Q2T9P3", "url": "https://www.uniprot.org/uniprotkb/Q2T9P3" } ], "pmid": "" }, { "name": "negative regulation of protein catabolic process", "id": "GO:0042177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042177", "evidence": [ { "database": "UniProtKB", "id": "Q2T9P3", "url": "https://www.uniprot.org/uniprotkb/Q2T9P3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "Q2T9P3", "url": "https://www.uniprot.org/uniprotkb/Q2T9P3" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "Q2T9P3", "url": "https://www.uniprot.org/uniprotkb/Q2T9P3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9P3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 394, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9P3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9P3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 310 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 215, "end_pos": 217 } ] }, 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Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. 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"616841", "url": "https://www.ncbi.nlm.nih.gov/gene/616841", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616841", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616841", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9Q7", "url": "https://www.orthodb.org/?gene=Q2T9Q7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23349", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23349", "database": "PANTHER", "categories": [ "Protein 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214, "header": "sp|Q2T9Q7-1|TCF23_BOVIN Isoform 1 of Transcription factor 23 OS=Bos taurus OX=9913 GN=TCF23 PE=2 SV=1 CANONICAL=Q2T9Q7-1" }, "isoforms": [ { "isoform_ac": "Q2T9Q7-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q7/entry#Q2T9Q7-1", "sequence": { "sequence": "MSQREARGARAMPGLGQSPAKATPRLLAGTERKRSRLSRRGQDLWEESSWSNQRWSRTAPNPRGARARSLARGRSEASPENAARERSRVRTLRQAFLALQATLPAVPPDTKLSKLDVLVLATSYIAHLTRTLGQEMPGPSWPPFLRGLRYLHPLKKWPMRSRLYAGGLGCSGLDSTTASNSGQRTKEAEAGPHVSGEPDALLSTRQLSPAPSDK", "length": 214, "header": "sp|Q2T9Q7-1|TCF23_BOVIN Isoform 1 of Transcription factor 23 OS=Bos taurus OX=9913 GN=TCF23 PE=2 SV=1 CANONICAL=Q2T9Q7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616841", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616841", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, 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"GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Q7", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9Q7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 214, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9Q7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9Q7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2T9Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Q7" }, { "id": "PRU00981", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00981" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "bHLH", "eco_id": "ECO_0000255", "start_pos": 76, "end_pos": 128, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, 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"total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9R6-1", "uniprot_ac": "Q2T9R6", "uniprot_id": "NIT2_BOVIN", "mass": { "chemical_mass": 30518.0, "monoisotopic_mass": 30518.0 }, "refseq": { "ac": "NP_001033222", "name": "omega-amidase NIT2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033222" }, "gene_names": [ { "name": "NIT2", "type": "recommended", "evidence": [ { "id": "Q2T9R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9R6" } ] }, { "name": "NIT2", "type": "synonym", "evidence": [ { "id": "NP_001033222", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033222" } ] } ], "protein_names": [ { "name": "Omega-amidase NIT2", "type": "recommended", "evidence": [ { "id": "Q2T9R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9R6/entry#names_and_taxonomy" } ] }, { "name": "3.5.1.3", "type": "synonym", "evidence": [ { "id": "Q2T9R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9R6/entry#names_and_taxonomy" } ] }, { "name": "Nitrilase homolog 2", "type": "synonym", "evidence": [ { "id": "Q2T9R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9R6/entry#names_and_taxonomy" } ] }, { "name": "nitrilase homolog 2", "type": "synonym", "evidence": [ { "id": "NP_001033222", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033222" } ] }, { "name": "omega-amidase NIT2", "type": "synonym", "evidence": [ { "id": "NP_001033222", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033222" } ] } ], "function": [ { "annotation": "Has omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively.", "evidence": [ { "database": "UniProtKB", "id": "Q2T9R6", "url": "https://www.uniprot.org/uniprotkb/Q2T9R6#function" }, { "database": "UniProtKB", "id": "Q9NQR4", "url": "https://www.uniprot.org/uniprotkb/Q9NQR4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9R6", "url": "https://www.uniprot.org/uniprotkb/Q2T9R6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NIT2", "url": "https://www.uniprot.org/uniprotkb/Q2T9R6", "locus": { "chromosome": "1", "start_pos": 44637448, "end_pos": 44617616, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004833", "url": "https://www.ensembl.org/id/ENSBTAG00000004833" } ] } } ], "crossref": [ { "id": "Q2T9R6", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9R6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07572", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07572", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "520620", "url": "https://www.ncbi.nlm.nih.gov/gene/520620", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036526", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036526", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520620", "url": 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and Pathway" ] }, { "id": "59412", "url": "https://www.rhea-db.org/rhea/59412", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9R6", "url": "https://www.uniprot.org/uniprotkb/Q2T9R6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9R6-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9R6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATFRLALIQLQVSSIKSENLTRACGLIREASKQGAQIVSLPECFNSPYGTKYFPDYAEKIPGDSTQKLSEVAKECSMYVIGGSIPEKDAGKLYNTCAVFGPDGTLLVKHRKLHLFDIDVPGKITFQESETLSPGDSFSLFDTPYCRVGLGICYDIRFAELAQIYAQRGCQLLVYPGAFNLTTGPAHWELLQRGRAVDNQVYVATASPARDEKASYVAWGHSTVVNPWGEVLAKAGTEETIVYADIDLKKLAEIRQQIPIFSQKRSDLYEVEAKKS", "length": 276, "header": "sp|Q2T9R6-1|NIT2_BOVIN Isoform 1 of Omega-amidase NIT2 OS=Bos taurus OX=9913 GN=NIT2 PE=2 SV=1 CANONICAL=Q2T9R6-1" }, "isoforms": [ { "isoform_ac": "Q2T9R6-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9R6/entry#Q2T9R6-1", "sequence": { "sequence": "MATFRLALIQLQVSSIKSENLTRACGLIREASKQGAQIVSLPECFNSPYGTKYFPDYAEKIPGDSTQKLSEVAKECSMYVIGGSIPEKDAGKLYNTCAVFGPDGTLLVKHRKLHLFDIDVPGKITFQESETLSPGDSFSLFDTPYCRVGLGICYDIRFAELAQIYAQRGCQLLVYPGAFNLTTGPAHWELLQRGRAVDNQVYVATASPARDEKASYVAWGHSTVVNPWGEVLAKAGTEETIVYADIDLKKLAEIRQQIPIFSQKRSDLYEVEAKKS", "length": 276, "header": "sp|Q2T9R6-1|NIT2_BOVIN Isoform 1 of Omega-amidase NIT2 OS=Bos taurus OX=9913 GN=NIT2 PE=2 SV=1 CANONICAL=Q2T9R6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:520620", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520620", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "asparagine metabolic process", "id": "GO:0006528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006528", "evidence": [ { "database": "UniProtKB", "id": "Q2T9R6", "url": 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"database": "UniProtKB", "id": "Q2T9R6", "url": "https://www.uniprot.org/uniprotkb/Q2T9R6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2T9R6", "url": "https://www.uniprot.org/uniprotkb/Q2T9R6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" }, { "start_pos": 20, "end_pos": 22, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "32963", "name": "", "equation": "2-oxoglutaramate + H2O = 2-oxoglutarate + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MJ59-1", "Q2T9R6-1" ], "evidence": [ { "id": "32963", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/32963" } ] }, { "id": "59412", "name": "", "equation": "2-oxosuccinamate + H2O = oxaloacetate + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MJ59-1", "Q2T9R6-1" ], "evidence": [ { "id": "59412", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/59412" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MJ59", "gene_name": "NIT2", "activity": [ { "ec_number": "3.5.1.3", "activity": "2-oxosuccinamate + H2O = oxaloacetate + NH4(+).", "evidence": [ { "id": "F1MJ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ59" } ] }, { "ec_number": "3.5.1.3", "activity": "", "evidence": [ { "id": "F1MJ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ59" } ] } ] }, { "uniprot_ac": "Q2T9R6", "gene_name": "NIT2", "activity": [ { "ec_number": "3.5.1.3", "activity": "2-oxosuccinamate + H2O = oxaloacetate + NH4(+).", "evidence": [ { "id": "Q2T9R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9R6" } ] }, { "ec_number": "3.5.1.3", "activity": "", "evidence": [ { "id": "Q2T9R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9R6" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9R6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 276, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9R6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9R6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2T9R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9R6" }, { "id": "PRU00054", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00054" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CN hydrolase", "eco_id": "ECO_0000255", "start_pos": 4, "end_pos": 248, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.5.1.3", "ec_name": "2-oxosuccinamate + H2O = oxaloacetate + NH4(+).", "evidence": [ { "id": "3.5.1.3", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3" }, { "id": "3.5.1.3", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.5.1.3" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 180, "end_pos": 182 }, { "start_pos": 20, "end_pos": 22 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9S3-1", "uniprot_ac": "Q2T9S3", "uniprot_id": "RPC6_BOVIN", "mass": { "chemical_mass": 35684.0, "monoisotopic_mass": 35684.0 }, "refseq": { "ac": "NP_001033237", "name": "DNA-directed RNA polymerase III subunit RPC6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033237" }, "gene_names": [ { "name": "POLR3F", "type": "recommended", "evidence": [ { "id": "Q2T9S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S3" } ] }, { "name": "POLR3F", "type": "synonym", "evidence": [ { "id": "NP_001033237", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033237" } ] } ], "protein_names": [ { "name": "DNA-directed RNA polymerase III subunit RPC6", "type": "recommended", "evidence": [ { "id": "Q2T9S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S3/entry#names_and_taxonomy" } ] }, { "name": "DNA-directed RNA polymerase III subunit F", "type": "synonym", "evidence": [ { "id": "NP_001033237", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033237" }, { "id": "Q2T9S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S3/entry#names_and_taxonomy" } ] }, { "name": "DNA-directed RNA polymerase III subunit RPC6", "type": "synonym", "evidence": [ { "id": "NP_001033237", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033237" } ] }, { "name": "RNA polymerase III subunit C6", "type": "synonym", "evidence": [ { "id": "NP_001033237", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033237" }, { "id": "Q2T9S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S3/entry#names_and_taxonomy" } ] }, { "name": "polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa", "type": "synonym", "evidence": [ { "id": "NP_001033237", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033237" } ] } ], "function": [ { "annotation": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Part of POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer that coordinates the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, including varicella zoster virus. Acts as a nuclear and cytosolic DNA sensor detecting AT-rich DNA, involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. Preferentially binds double-stranded DNA (dsDNA) (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S3", "url": "https://www.uniprot.org/uniprotkb/Q2T9S3#function" }, { "database": "UniProtKB", "id": "Q9H1D9", "url": "https://www.uniprot.org/uniprotkb/Q9H1D9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9S3", "url": "https://www.uniprot.org/uniprotkb/Q2T9S3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "POLR3F", "url": "https://www.uniprot.org/uniprotkb/Q2T9S3", "locus": { "chromosome": "13", "start_pos": 38546652, "end_pos": 38533471, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008825", "url": "https://www.ensembl.org/id/ENSBTAG00000008825" } ] } } ], "crossref": [ { "id": "Q2T9S3", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9S3", "database": "AlphaFoldDB", "categories": [] }, { "id": "529410", "url": "https://www.ncbi.nlm.nih.gov/gene/529410", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016049", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016049", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529410", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529410", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9S3", "url": 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"MAEVKVKVQPPDADPVEIENRIIELCHQFPHGITDQVIQNEMPHIEAQQRAVAINRLLSMGQLDLLRSNTGLLYRIKDSQNAGKMKGSDNQEKLVYQIIEDAGNKGIWSRDIRYKSNLPLTEINKILKNLESKKLIKAVKSVAASKKKVYMLYNLQPDRSVTGGAWYSDQDFESEFVEVLNQQCFKFLQNKAETARESKQNPMIQRNSSFASSHEVWKYICELGISKVELSMEDIETILNTLIYDGKVEMTIIAAKEGTVGSVDGHMKLYRAVSPIIPPTGLVRAPCGLCPVFDDCHEGGEISPSNCIYMTEWLEF", "length": 316, "header": "sp|Q2T9S3-1|RPC6_BOVIN Isoform 1 of DNA-directed RNA polymerase III subunit RPC6 OS=Bos taurus OX=9913 GN=POLR3F PE=2 SV=1 CANONICAL=Q2T9S3-1" }, "isoforms": [ { "isoform_ac": "Q2T9S3-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9S3/entry#Q2T9S3-1", "sequence": { "sequence": "MAEVKVKVQPPDADPVEIENRIIELCHQFPHGITDQVIQNEMPHIEAQQRAVAINRLLSMGQLDLLRSNTGLLYRIKDSQNAGKMKGSDNQEKLVYQIIEDAGNKGIWSRDIRYKSNLPLTEINKILKNLESKKLIKAVKSVAASKKKVYMLYNLQPDRSVTGGAWYSDQDFESEFVEVLNQQCFKFLQNKAETARESKQNPMIQRNSSFASSHEVWKYICELGISKVELSMEDIETILNTLIYDGKVEMTIIAAKEGTVGSVDGHMKLYRAVSPIIPPTGLVRAPCGLCPVFDDCHEGGEISPSNCIYMTEWLEF", "length": 316, "header": "sp|Q2T9S3-1|RPC6_BOVIN Isoform 1 of DNA-directed RNA polymerase III subunit RPC6 OS=Bos taurus OX=9913 GN=POLR3F PE=2 SV=1 CANONICAL=Q2T9S3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:529410", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529410", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S3", "url": "https://www.uniprot.org/uniprotkb/Q2T9S3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S3", "url": "https://www.uniprot.org/uniprotkb/Q2T9S3" } ], "pmid": "" }, { "name": "RNA polymerase III complex", "id": "GO:0005666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005666", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S3", "url": "https://www.uniprot.org/uniprotkb/Q2T9S3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S3", "url": "https://www.uniprot.org/uniprotkb/Q2T9S3" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S3", "url": "https://www.uniprot.org/uniprotkb/Q2T9S3" } ], "pmid": "" }, { "name": "transcription by RNA polymerase III", "id": "GO:0006383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006383", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S3", "url": "https://www.uniprot.org/uniprotkb/Q2T9S3" } ], "pmid": "" }, { "name": "positive regulation of innate immune response", "id": "GO:0045089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045089", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S3", "url": "https://www.uniprot.org/uniprotkb/Q2T9S3" } ], "pmid": "" }, { "name": "positive regulation of interferon-beta production", "id": "GO:0032728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032728", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S3", "url": "https://www.uniprot.org/uniprotkb/Q2T9S3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S3", "url": "https://www.uniprot.org/uniprotkb/Q2T9S3" } ], "pmid": "" }, { "name": "double-stranded DNA binding", "id": "GO:0003690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S3", "url": "https://www.uniprot.org/uniprotkb/Q2T9S3" } ], "pmid": "" }, { "name": "iron-sulfur cluster binding", "id": "GO:0051536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051536", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S3", "url": "https://www.uniprot.org/uniprotkb/Q2T9S3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9S3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 316, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9S3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9S3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], 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Recognizes and ubiquitinates BIRC2 and the cell cycle regulator DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. Mediates the ubiquitination and proteasomal degradation of UXT isoform 2, thereby impairing the NF-kappa-B signaling pathway. Inhibits NF-kappa-B pathway also by promoting the ubiquitinatioin of TRAF2 (By similarity). Affects the assembly state and activity of the proteasome in the cells including neurons by ubiquitinating the proteasomal subunit PSMA2 via 'Lys-63'-linked polyubiquitin chains (By similarity). Promotes 'Lys-48'-linked polyubiquitination SIRT7, leading to the hydrogen peroxide-induced cell death (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S7", "url": "https://www.uniprot.org/uniprotkb/Q2T9S7#function" }, { "database": "UniProtKB", "id": "Q9Y3I1", "url": "https://www.uniprot.org/uniprotkb/Q9Y3I1#function" }, { "database": "UniProtKB", "id": "Q3U7U3", "url": "https://www.uniprot.org/uniprotkb/Q3U7U3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9S7", "url": "https://www.uniprot.org/uniprotkb/Q2T9S7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO7", "url": "https://www.uniprot.org/uniprotkb/Q2T9S7", "locus": { "chromosome": "5", "start_pos": 71120096, "end_pos": 71099853, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020634", "url": "https://www.ensembl.org/id/ENSBTAG00000020634" } ] } } ], "crossref": [ { "id": "Q2T9S7", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9S7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22087", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22087", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508235", "url": "https://www.ncbi.nlm.nih.gov/gene/508235", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021625", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021625", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047118", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047118", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508235", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508235", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9S7", "url": "https://www.orthodb.org/?gene=Q2T9S7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15537", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15537", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15537:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15537:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11566", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11566", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033148", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9S7", "url": "https://www.uniprot.org/uniprotkb/Q2T9S7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9S7-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9S7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLRVRLQKRTWPLDMPEVEPTLGQLRAYLSQALPTWGYSSDARFAITLNNKDALTGDEETLASYGIVSGDLLCLILEDAIAAPNLPSSTVSEHSSVQNNDQPSLATSSSQSNIQDAQLHDSLQGQATQSEVWNDDSVSGPGQHFEAEAVPDVVDVEEGTGYYLAEPMLCSESVEGQVPHSLEILYQSADCLNPCDALIVSIHLLMLESGYIPQGTEAKAVSMPQNWRLGGVYKLQYTHPLCEGGSAALTCVPLGNLIVINATLKINSEVRSVKRLQLLPESFICKEESGENVAMIYKDLQKLSRLFKDQLVYPLLAFTRQALNLPDVFGLVVLPLELKLRIFRLLDVRSVLSLSAVCRDLCITSNDQLLWRCLYLRDFRDGSIRGRDTDWKELYKKRYKQRKEAQRGRHVMFLPSSPHPIPFYPSPLHPRPFPPSSLHPPGIIGGEYDQRLTLPYVGDPINSLIPGPGETPSQFPPLRPRFDPVGPLPGPNPILPGRGGPSDRFPLRPSRGWPTDSRLPFM", "length": 522, "header": "sp|Q2T9S7-1|FBX7_BOVIN Isoform 1 of F-box only protein 7 OS=Bos taurus OX=9913 GN=FBXO7 PE=2 SV=1 CANONICAL=Q2T9S7-1" }, "isoforms": [ { "isoform_ac": "Q2T9S7-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9S7/entry#Q2T9S7-1", "sequence": { "sequence": "MKLRVRLQKRTWPLDMPEVEPTLGQLRAYLSQALPTWGYSSDARFAITLNNKDALTGDEETLASYGIVSGDLLCLILEDAIAAPNLPSSTVSEHSSVQNNDQPSLATSSSQSNIQDAQLHDSLQGQATQSEVWNDDSVSGPGQHFEAEAVPDVVDVEEGTGYYLAEPMLCSESVEGQVPHSLEILYQSADCLNPCDALIVSIHLLMLESGYIPQGTEAKAVSMPQNWRLGGVYKLQYTHPLCEGGSAALTCVPLGNLIVINATLKINSEVRSVKRLQLLPESFICKEESGENVAMIYKDLQKLSRLFKDQLVYPLLAFTRQALNLPDVFGLVVLPLELKLRIFRLLDVRSVLSLSAVCRDLCITSNDQLLWRCLYLRDFRDGSIRGRDTDWKELYKKRYKQRKEAQRGRHVMFLPSSPHPIPFYPSPLHPRPFPPSSLHPPGIIGGEYDQRLTLPYVGDPINSLIPGPGETPSQFPPLRPRFDPVGPLPGPNPILPGRGGPSDRFPLRPSRGWPTDSRLPFM", "length": 522, "header": "sp|Q2T9S7-1|FBX7_BOVIN Isoform 1 of F-box only protein 7 OS=Bos taurus OX=9913 GN=FBXO7 PE=2 SV=1 CANONICAL=Q2T9S7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508235", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508235", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S7", "url": "https://www.uniprot.org/uniprotkb/Q2T9S7" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S7", "url": "https://www.uniprot.org/uniprotkb/Q2T9S7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S7", "url": "https://www.uniprot.org/uniprotkb/Q2T9S7" } ], "pmid": "" }, { "name": "ubiquitin ligase complex", "id": "GO:0000151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000151", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S7", "url": "https://www.uniprot.org/uniprotkb/Q2T9S7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S7", "url": "https://www.uniprot.org/uniprotkb/Q2T9S7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein targeting to mitochondrion", "id": "GO:0006626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006626", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S7", "url": "https://www.uniprot.org/uniprotkb/Q2T9S7" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S7", "url": "https://www.uniprot.org/uniprotkb/Q2T9S7" } ], "pmid": "" }, { "name": "autophagy of mitochondrion", "id": "GO:0000422", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000422", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S7", "url": "https://www.uniprot.org/uniprotkb/Q2T9S7" } ], "pmid": "" }, { "name": "positive regulation of autophagy of mitochondrion", "id": "GO:1903599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903599", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S7", "url": "https://www.uniprot.org/uniprotkb/Q2T9S7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9S7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 522, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9S7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9S7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S7" }, { "id": "PRU00080", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00080" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000255", "start_pos": 328, "end_pos": 374, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 261, "end_pos": 263 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9S8-1", "uniprot_ac": "Q2T9S8", "uniprot_id": "AATC2_BOVIN", "mass": { "chemical_mass": 45918.0, "monoisotopic_mass": 45918.0 }, "refseq": { "ac": "NP_001033147", "name": "putative aspartate aminotransferase, cytoplasmic 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033147" }, "gene_names": [ { "name": "GOT1L1", "type": "recommended", "evidence": [ { "id": "Q2T9S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S8" } ] }, { "name": "GOT1L1", "type": "synonym", "evidence": [ { "id": "NP_001033147", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033147" } ] } ], "protein_names": [ { "name": "Putative aspartate aminotransferase, cytoplasmic 2", "type": "recommended", "evidence": [ { "id": "Q2T9S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S8/entry#names_and_taxonomy" } ] }, { "name": "2.6.1.1", "type": "synonym", "evidence": [ { "id": "Q2T9S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S8/entry#names_and_taxonomy" } ] }, { "name": "Glutamate oxaloacetate transaminase 1-like protein 1", "type": "synonym", "evidence": [ { "id": "Q2T9S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S8/entry#names_and_taxonomy" } ] }, { "name": "Transaminase A-like protein 1", "type": "synonym", "evidence": [ { "id": "Q2T9S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S8/entry#names_and_taxonomy" } ] }, { "name": "glutamate oxaloacetate transaminase 1-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001033147", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033147" } ] }, { "name": "putative aspartate aminotransferase, cytoplasmic 2", "type": "synonym", "evidence": [ { "id": "NP_001033147", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033147" } ] }, { "name": "transaminase A-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001033147", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033147" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9S8", "url": "https://www.uniprot.org/uniprotkb/Q2T9S8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GOT1L1", "url": "https://www.uniprot.org/uniprotkb/Q2T9S8", "locus": { "chromosome": "27", "start_pos": 33181305, "end_pos": 33186909, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016446", "url": "https://www.ensembl.org/id/ENSBTAG00000016446" } ] } } ], "crossref": [ { "id": "Q2T9S8", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9S8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016446", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016446", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00609", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00609", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507913", "url": "https://www.ncbi.nlm.nih.gov/gene/507913", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000796", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000796", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004839", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004839", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507913", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507913", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MSMIKSK", "url": "https://omabrowser.org/oma/group/MSMIKSK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2T9S8", "url": "https://www.orthodb.org/?gene=Q2T9S8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11879", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11879", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11879:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11879:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00155", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00155", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033147", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "21824", "url": "https://www.rhea-db.org/rhea/21824", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9S8", "url": "https://www.uniprot.org/uniprotkb/Q2T9S8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9S8-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9S8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPTLSVFTDVPMAQKLEGSLLKTYKQDDNPNKMFLAYKVCMTSKGRPWVSSVVRKTRMQIAQDPSLNYEYTPVMGMKSFVQASLNLLFGKNSQVIVENRAGGVQTVGDSGAFQLGAQFLKSWCQSSQIVYIVSSQKEPHGLIFQDMGFTVYEHTFWDSAHLCLDPNMLLDVVKHAPHGCVFVIGSMGNCQLTPSQWTQLMTLMKSKEIFPFFDIPYQGLSTGDLEEDARFLHYFVSQGFEFFCSQSLSKNFGIYDEGVGTLVVVTLDNQLLLRVLSQLMNFARALWLNPPTTGARIITSVLCNPAMQGEWRQSLEGVVENVMMTKEKVKEKLRLLGTPGSWDHITEQKGSHSYLGLNSQQVEYLISEKHIYIPKNGRINFTCINSYNIDYITSSINEAVCFTKDSER", "length": 407, "header": "sp|Q2T9S8-1|AATC2_BOVIN Isoform 1 of Putative aspartate aminotransferase, cytoplasmic 2 OS=Bos taurus OX=9913 GN=GOT1L1 PE=2 SV=1 CANONICAL=Q2T9S8-1" }, "isoforms": [ { "isoform_ac": "Q2T9S8-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9S8/entry#Q2T9S8-1", "sequence": { "sequence": "MPTLSVFTDVPMAQKLEGSLLKTYKQDDNPNKMFLAYKVCMTSKGRPWVSSVVRKTRMQIAQDPSLNYEYTPVMGMKSFVQASLNLLFGKNSQVIVENRAGGVQTVGDSGAFQLGAQFLKSWCQSSQIVYIVSSQKEPHGLIFQDMGFTVYEHTFWDSAHLCLDPNMLLDVVKHAPHGCVFVIGSMGNCQLTPSQWTQLMTLMKSKEIFPFFDIPYQGLSTGDLEEDARFLHYFVSQGFEFFCSQSLSKNFGIYDEGVGTLVVVTLDNQLLLRVLSQLMNFARALWLNPPTTGARIITSVLCNPAMQGEWRQSLEGVVENVMMTKEKVKEKLRLLGTPGSWDHITEQKGSHSYLGLNSQQVEYLISEKHIYIPKNGRINFTCINSYNIDYITSSINEAVCFTKDSER", "length": 407, "header": "sp|Q2T9S8-1|AATC2_BOVIN Isoform 1 of Putative aspartate aminotransferase, cytoplasmic 2 OS=Bos taurus OX=9913 GN=GOT1L1 PE=2 SV=1 CANONICAL=Q2T9S8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:507913", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507913", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VQC4-1", "protein_name": "Putative aspartate aminotransferase, cytoplasmic 2", "gene_name": "GOT1L1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPSLSVFVDVPLAQKLEGSLLKTYKQDNYPNKMFLAYKVCMTSEGQPWVSSVVSKIRLQIAQDPSLDYEYTPVMGMESFIQASLKLLFGKHSQVIVENRAGGVHTVGDSGAFQLGAQFLKTWHRDSQIVYIISSQKEPHGLIFQDMGFTVSEYIFWDAEQLCLDPSVLLNVVEQAPHGCVFVIGNISNCKLTQSQWTKLTALMKSKQIFPFFDISYQGLSTSDLEEDTRFLDYFVSQDLEFFCSQSLSKNFGIYDEGVGILVVVALNNQLLLRVLSQLMNFARALWLNPPTTGARIITSILCNPALQEEWKQSLEGIIENIMLIKEKVKEKLRLLGTPGSWDHITEQKGSHSYLGLNSKQVEYLVKKKHVYIPKNGRINFTCINPCNIDYITQSINEAVCFTKP", "length": 404 }, "evidence": [ { "id": "Q2T9S8", "url": "https://omabrowser.org/oma/group/Q2T9S8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7F4Y9-1", "protein_name": "Putative aspartate aminotransferase, cytoplasmic 2", "gene_name": "Got1l1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTSLSVFRDIVPAQKLEGSLLKIYKQDDYPNKMFLAYRVCMTDEGHPWVSLVVRKTRLQISQDPSLNYEYLPQMGMKSFVQAALELLFGKHSQAIAEKRVGGVHTVGDSGAFQLGAQFLRTWRKNLKTVCIVSCQKEQYGLIFQEMGFTVYEYLIWNPKELCSDPKMFFEVMEHIPADSILVIGNIIDCRFSQNQWAKLMSIIKKKQIFPFFDIPCQGLSTGNLEEDTRLLQYFVSLGLEFFCNQSLSKNFGIYDEGVGILAVAALSNQNLLCVLSQLMNYVEALWGSPPATGARIITSILCNPALFGEWKQSLKGVVENIMLIKEKVKEKLRLLGTPGTWNHITEQSGFHGYLGLNYQQVEYLTKKKHIYIPKTSRINFTCINIRNIDYITQSIHEAVKLTEECP", "length": 406 }, "evidence": [ { "id": "Q2T9S8", "url": "https://omabrowser.org/oma/group/Q2T9S8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0ABK0LWJ8-1", "protein_name": "Putative aspartate aminotransferase, cytoplasmic 2", "gene_name": "Got1l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTSLSVFRDVPIAQKLEGSLLKIYRQDDSSVKMFLAYKVCMTEGGHPWVSLVVRKTRLQIAEDPSLNYEYLPLAGLKSFIQASLELLFGKHSQAIVEKRVGGVHIVGESGAFQLGAQFLKIWRKNLKTVCIISCQNEQCGLIFRDMGFTVYEYSVWNSTDLCSDPSIFVEVLQHIPAGSILVIGNISDCRFTQNQWTKLMSIIKSKQIFPFFDIPCQGLSTGDLEEDSKFLQHFVSLGFEFFCSQSLSKNFGIYDEGVGILVVAALSNQHLLCVISQLMDYVQALWGNPPATGARIITSILCNPALFGEWKQSLKGVVENIMLIKEKVKEKLRLLGTPGSWNHITRQSGTHGYLGLNCILRGLFPK", "length": 366 }, "evidence": [ { "id": "Q2T9S8", "url": "https://omabrowser.org/oma/group/Q2T9S8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TSV6-1", "protein_name": "Aspartate aminotransferase, cytoplasmic 2", "gene_name": "Got1l1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTSLSVFRDVPTAQKLEGSLLKIYRQDGYPSKLFLAYKVCMTEEGHPWVSLVVHKTRLQIAEDPSLDYEYLPLVGLKSFIQSSLELLFGKHSEAIAEKRVGGVHIVGESGAFQLGAQFLKTWRKNVKIVCIVSCQKEQCGLIFQDMGFIVYEYSIWNASDLCSDPSMFVEVLQHIPVGSILVIGNITDCKFTQNQWTKLMSIIKSKQIFPFFDIPCQGLSTGDLEEDTKILQYFVSLGLEFFCSQSLSKNFGIYDEGVGILVVAALSNQHLLCVLSQLMDYVQALWGNPPATGARIITSILCNPALFGEWKQSLKGVVENMMLIKEKVKEKLRLLGTPGSWDHITRQSGTHGYLGLTYQQVEFLVKKKHIYLPKTSRINFTCINARNIDYITQSIHEAVMLTEG", "length": 404 }, "evidence": [ { "id": "Q2T9S8", "url": "https://omabrowser.org/oma/group/Q2T9S8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NHS2-1", "protein_name": "Aspartate aminotransferase, cytoplasmic 2", "gene_name": "GOT1L1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPTLSVFMDVPLAHKLEGSLLKTYKQDDYPNKIFLAYRVCMTNEGHPWVSLVVQKTRLQISQDPSLNYEYLPTMGLKSFIQASLALLFGKHSQAIVENRVGGVHTVGDSGAFQLGVQFLRAWHKDARIVYIISSQKELHGLVFQDMGFTVYEYSVWDPKKLCMDPDILLNVVEQIPHGCVLVMGNIIDCKLTPSGWAKLMSMIKSKQIFPFFDIPCQGLYTSDLEEDTRILQYFVSQGFEFFCSQSLSKNFGIYDEGVGMLVVVAVNNQQLLCVLSQLEGLAQALWLNPPNTGARVITSILCNPALLGEWKQSLKEVVENIMLTKEKVKEKLQLLGTPGSWGHITEQSGTHGYLGLNSQQVEYLVRKKHIYIPKNGQINFSCINANNINYITEGINEAVLLTESSEMCLPKEKKTLIGIKL", "length": 421 }, "evidence": [ { "id": "Q2T9S8", "url": "https://omabrowser.org/oma/group/Q2T9S8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S8", "url": "https://www.uniprot.org/uniprotkb/Q2T9S8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S8", "url": "https://www.uniprot.org/uniprotkb/Q2T9S8" } ], "pmid": "" }, { "name": "L-aspartate:2-oxoglutarate aminotransferase activity", "id": "GO:0004069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004069", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S8", "url": "https://www.uniprot.org/uniprotkb/Q2T9S8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "aspartate biosynthetic process", "id": "GO:0006532", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006532", "evidence": [ { "database": "UniProtKB", "id": "Q2T9S8", "url": "https://www.uniprot.org/uniprotkb/Q2T9S8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 379, "end_pos": 381, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21824", "name": "", "equation": "L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P12344-1", "P33097-1", "Q2T9S8-1" ], "evidence": [ { "id": "21824", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21824" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P12344", "gene_name": "GOT2", "activity": [ { "ec_number": "2.6.1.1", "activity": "L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.", "evidence": [ { "id": "P12344", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P12344" } ] }, { "ec_number": "2.6.1.1", "activity": "", "evidence": [ { "id": "P12344", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P12344" } ] } ] }, { "uniprot_ac": "P33097", "gene_name": "GOT1", "activity": [ { "ec_number": "2.6.1.1", "activity": "L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.", "evidence": [ { "id": "P33097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P33097" } ] }, { "ec_number": "2.6.1.3", "activity": "L-cysteine + 2-oxoglutarate = 2-oxo-3-sulfanylpropanoate + L-glutamate.", "evidence": [ { "id": "P33097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P33097" } ] }, { "ec_number": "2.6.1.3", "activity": "", "evidence": [ { "id": "P33097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P33097" } ] }, { "ec_number": "2.6.1.1", "activity": "", "evidence": [ { "id": "P33097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P33097" } ] } ] }, { "uniprot_ac": "Q2T9S8", "gene_name": "GOT1L1", "activity": [ { "ec_number": "2.6.1.1", "activity": "L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.", "evidence": [ { "id": "Q2T9S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S8" } ] }, { "ec_number": "2.6.1.1", "activity": "", "evidence": [ { "id": "Q2T9S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S8" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9S8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 407, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9S8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9S8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.6.1.1", "ec_name": "L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.", "evidence": [ { "id": "2.6.1.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.1" }, { "id": "2.6.1.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.6.1.1" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], 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Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (By similarity). 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"id": "Q2T9U8", "url": "https://www.uniprot.org/uniprotkb/Q2T9U8" } ], "pmid": "" }, { "name": "neuropeptide signaling pathway", "id": "GO:0007218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007218", "evidence": [ { "database": "UniProtKB", "id": "Q2T9U8", "url": "https://www.uniprot.org/uniprotkb/Q2T9U8" } ], "pmid": "" }, { "name": "negative regulation of interleukin-6 production", "id": "GO:0032715", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032715", "evidence": [ { "database": "UniProtKB", "id": "Q2T9U8", "url": "https://www.uniprot.org/uniprotkb/Q2T9U8" } ], "pmid": "" }, { "name": "positive regulation of hormone secretion", "id": "GO:0046887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046887", "evidence": [ { "database": "UniProtKB", "id": "Q2T9U8", "url": "https://www.uniprot.org/uniprotkb/Q2T9U8" } ], "pmid": "" }, { "name": "positive regulation of osteoclast proliferation", "id": "GO:0090290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090290", "evidence": [ { "database": "UniProtKB", "id": "Q2T9U8", "url": "https://www.uniprot.org/uniprotkb/Q2T9U8" } ], "pmid": "" }, { "name": "positive regulation of testosterone secretion", "id": "GO:2000845", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000845", "evidence": [ { "database": "UniProtKB", "id": "Q2T9U8", "url": "https://www.uniprot.org/uniprotkb/Q2T9U8" } ], "pmid": "" }, { "name": "antiviral innate immune response", "id": "GO:0140374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140374", "evidence": [ { "database": "UniProtKB", "id": "Q2T9U8", "url": "https://www.uniprot.org/uniprotkb/Q2T9U8" } ], "pmid": "" }, { "name": "Leydig cell proliferation", "id": "GO:0160024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160024", "evidence": [ { "database": "UniProtKB", "id": "Q2T9U8", "url": "https://www.uniprot.org/uniprotkb/Q2T9U8" } ], "pmid": "" }, { "name": "positive regulation of respiratory gaseous exchange", "id": "GO:1903942", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903942", "evidence": [ { "database": "UniProtKB", "id": "Q2T9U8", "url": "https://www.uniprot.org/uniprotkb/Q2T9U8" } ], "pmid": "" }, { "name": "sneeze reflex", "id": "GO:0160023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160023", "evidence": [ { "database": "UniProtKB", "id": "Q2T9U8", "url": "https://www.uniprot.org/uniprotkb/Q2T9U8" } ], "pmid": "" }, { "name": "sensory perception of itch", "id": "GO:0160025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160025", "evidence": [ { "database": "UniProtKB", "id": "Q2T9U8", "url": "https://www.uniprot.org/uniprotkb/Q2T9U8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q2T9U8", "url": "https://www.uniprot.org/uniprotkb/Q2T9U8" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "Q2T9U8", "url": "https://www.uniprot.org/uniprotkb/Q2T9U8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "neuropeptide hormone activity", "id": "GO:0005184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005184", "evidence": [ { "database": "UniProtKB", "id": "Q2T9U8", "url": "https://www.uniprot.org/uniprotkb/Q2T9U8" } ], "pmid": "" }, { "name": "neuromedin B receptor binding", "id": "GO:0031710", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031710", "evidence": [ { "database": "UniProtKB", "id": "Q2T9U8", "url": "https://www.uniprot.org/uniprotkb/Q2T9U8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9U8-F1", "pdb_chain": "global", "start_pos": 1, 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"url": "https://www.uniprot.org/uniprotkb/Q2T9V2/entry#names_and_taxonomy" } ] }, { "name": "dynein regulatory complex protein 9", "type": "synonym", "evidence": [ { "id": "NP_001033284", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033284" } ] } ], "function": [ { "annotation": "Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility.", "evidence": [ { "database": "UniProtKB", "id": "Q2T9V2", "url": "https://www.uniprot.org/uniprotkb/Q2T9V2#function" }, { "database": "UniProtKB", "id": "Q80W32", "url": "https://www.uniprot.org/uniprotkb/Q80W32#function" }, { "database": "UniProtKB", "id": "A8HQ54", "url": "https://www.uniprot.org/uniprotkb/A8HQ54#function" }, { "database": "UniProtKB", "id": "A3KQH2", "url": "https://www.uniprot.org/uniprotkb/A3KQH2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9V2", "url": "https://www.uniprot.org/uniprotkb/Q2T9V2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DRC9", "url": "https://www.uniprot.org/uniprotkb/Q2T9V2", "locus": {} } ], "crossref": [ { "id": "Q2T9V2", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9V2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd23766", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23766", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613455", "url": "https://www.ncbi.nlm.nih.gov/gene/613455", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042618", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042618", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060661", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060661", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613455", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613455", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9V2", "url": "https://www.orthodb.org/?gene=Q2T9V2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14871", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14871", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14871:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14871:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27661", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27661", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033284", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9V2", "url": "https://www.uniprot.org/uniprotkb/Q2T9V2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9V2-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9V2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEGLEASNLPPEAWPSEVTVSVTGEPPNTSVEEKEETAKEAVIETSPEIMKPLSILDVLRISAVLEDTTDQLSILNYIMPVQYEKRQSISMKDNKEMHLEGRSSEKVPLASNPSKISSPLVHKEEPKLPEIRQGGQFNKVQDLIFKKPTRQTIMNTETLKKIQIDRQFLSDVITETLEELQEEGTFTNLLKALGKERESKMHFYDTIAREENGRKKIKSLQKQLLNVKKERQAEVQNRNEYIAHLKDQLQEMKAKTNMENRYMKRNTELQISQTQKKCSKTEELLLEEIEKLRLKTEEENRIHAEIELFLRKEQQKLEEKLEFWMEKFDKDTEMKQNELNALKSAKASDLAHLQELAKTIREYEQVIIEDRIEKEKTRKKREQDDLEMRSIIKLQAWWRGTVVRREIGGFKMPKDKDDSKDVKGKGKEKDKRRGKK", "length": 437, "header": "sp|Q2T9V2-1|DRC9_BOVIN Isoform 1 of Dynein regulatory complex protein 9 OS=Bos taurus OX=9913 GN=DRC9 PE=2 SV=1 CANONICAL=Q2T9V2-1" }, "isoforms": [ { "isoform_ac": "Q2T9V2-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9V2/entry#Q2T9V2-1", "sequence": { "sequence": "MEEGLEASNLPPEAWPSEVTVSVTGEPPNTSVEEKEETAKEAVIETSPEIMKPLSILDVLRISAVLEDTTDQLSILNYIMPVQYEKRQSISMKDNKEMHLEGRSSEKVPLASNPSKISSPLVHKEEPKLPEIRQGGQFNKVQDLIFKKPTRQTIMNTETLKKIQIDRQFLSDVITETLEELQEEGTFTNLLKALGKERESKMHFYDTIAREENGRKKIKSLQKQLLNVKKERQAEVQNRNEYIAHLKDQLQEMKAKTNMENRYMKRNTELQISQTQKKCSKTEELLLEEIEKLRLKTEEENRIHAEIELFLRKEQQKLEEKLEFWMEKFDKDTEMKQNELNALKSAKASDLAHLQELAKTIREYEQVIIEDRIEKEKTRKKREQDDLEMRSIIKLQAWWRGTVVRREIGGFKMPKDKDDSKDVKGKGKEKDKRRGKK", "length": 437, "header": "sp|Q2T9V2-1|DRC9_BOVIN Isoform 1 of Dynein regulatory complex protein 9 OS=Bos taurus OX=9913 GN=DRC9 PE=2 SV=1 CANONICAL=Q2T9V2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613455", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613455", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "Q2T9V2", "url": "https://www.uniprot.org/uniprotkb/Q2T9V2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2T9V2", "url": "https://www.uniprot.org/uniprotkb/Q2T9V2" } ], "pmid": "" }, { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "Q2T9V2", "url": "https://www.uniprot.org/uniprotkb/Q2T9V2" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "Q2T9V2", "url": "https://www.uniprot.org/uniprotkb/Q2T9V2" } ], "pmid": "" }, { "name": "manchette", "id": "GO:0002177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002177", "evidence": [ { "database": "UniProtKB", "id": "Q2T9V2", "url": "https://www.uniprot.org/uniprotkb/Q2T9V2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "spermatid development", "id": "GO:0007286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "evidence": [ { "database": "UniProtKB", "id": "Q2T9V2", "url": "https://www.uniprot.org/uniprotkb/Q2T9V2" } ], "pmid": "" }, { "name": "cilium organization", "id": "GO:0044782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044782", "evidence": [ { "database": "UniProtKB", "id": "Q2T9V2", "url": "https://www.uniprot.org/uniprotkb/Q2T9V2" } ], "pmid": "" }, { "name": "sperm axoneme assembly", "id": "GO:0007288", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007288", "evidence": [ { "database": "UniProtKB", "id": "Q2T9V2", "url": "https://www.uniprot.org/uniprotkb/Q2T9V2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9V2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 437, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9V2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9V2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2T9V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9V2" }, { "id": "PRU00116", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00116" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IQ", "eco_id": "ECO_0000255", "start_pos": 388, "end_pos": 417, "start_aa": "Glu", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 29, "end_pos": 31 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9V5-1", "uniprot_ac": "Q2T9V5", "uniprot_id": "TRM6_BOVIN", "mass": { "chemical_mass": 55979.0, "monoisotopic_mass": 55979.0 }, "refseq": { "ac": "NP_001033129", "name": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033129" }, "gene_names": [ { "name": "TRMT6", "type": "recommended", "evidence": [ { "id": "Q2T9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9V5" } ] }, { "name": "TRM6", "type": "synonym", "evidence": [ { "id": "Q2T9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9V5" } ] }, { "name": "TRMT6", "type": "synonym", "evidence": [ { "id": "NP_001033129", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033129" } ] } ], "protein_names": [ { "name": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "type": "recommended", "evidence": [ { "id": "Q2T9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9V5/entry#names_and_taxonomy" } ] }, { "name": "mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6", "type": "synonym", "evidence": [ { "id": "NP_001033129", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033129" }, { "id": "Q2T9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9V5/entry#names_and_taxonomy" } ] }, { "name": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "type": "synonym", "evidence": [ { "id": "NP_001033129", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033129" } ] }, { "name": "tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6", "type": "synonym", "evidence": [ { "id": "NP_001033129", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033129" } ] }, { "name": "tRNA methyltransferase 6 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033129", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033129" } ] }, { "name": "tRNA(m1A58)-methyltransferase subunit TRM6", "type": "synonym", "evidence": [ { "id": "NP_001033129", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033129" }, { "id": "Q2T9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9V5/entry#names_and_taxonomy" } ] }, { "name": "tRNA(m1A58)MTase subunit TRM6", "type": "synonym", "evidence": [ { "id": "NP_001033129", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033129" }, { "id": "Q2T9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9V5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries.", "evidence": [ { "database": "UniProtKB", "id": "Q2T9V5", "url": "https://www.uniprot.org/uniprotkb/Q2T9V5#function" }, { "database": "UniProtKB", "id": "Q9UJA5", "url": "https://www.uniprot.org/uniprotkb/Q9UJA5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9V5", "url": "https://www.uniprot.org/uniprotkb/Q2T9V5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRMT6", "url": "https://www.uniprot.org/uniprotkb/Q2T9V5", "locus": { "chromosome": "13", "start_pos": 48110221, "end_pos": 48120755, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001314", "url": "https://www.ensembl.org/id/ENSBTAG00000001314" } ] } } ], "crossref": [ { "id": "Q2T9V5", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9V5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001314", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001314", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505816", "url": "https://www.ncbi.nlm.nih.gov/gene/505816", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR017423", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017423", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505816", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505816", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TRCRPYQ", "url": "https://omabrowser.org/oma/group/TRCRPYQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2T9V5", "url": "https://www.orthodb.org/?gene=Q2T9V5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12945", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12945", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12945:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12945:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04189", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04189", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033129", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033129", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9V5", "url": "https://www.uniprot.org/uniprotkb/Q2T9V5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9V5-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9V5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESSEDQPGPQPQYPGNHCIRDGDFVVLKREDVFKAVQVQRRKKVTFEKQWFYLDNIIGHSYGTTFEVTNGGSLQPKKKKEEPTSETKEAGTDNRNIIDDGKSQKLTQDDIKALKDKGIKGEEIVQQLIENSTTFRDKTEFAQDKYIKKKKKKYEAMITVVKPSTRILSVMYYAREPGKINHMRYDTLAQMLTLGNIRAGNKMIVMETCAGLVLGAMMERMGGFGSIIQLYPGGGPVRAATACFGFPKSFLSGLYEFPLNKVDSLLNGTFSAEMLSSEPKDIASVEESNGTLEEKQTSEQENEDSIAEAPESNHPEEQERMEIVSQDPDYKEPKESGSKKDYIQEKQRRQEEQKKRHLEAAALLSERNADGLIVASRFHPTPLLLSLLDFVAPSRPFVVYCQYKEPLLECYTKLRERGGVINLRLSETWLRNYQVLPDRSHPKLLMSGGGGYLLSGFTVAMDNLKADPSLKSSTSTLESHKTEEPAAKKRKCPESDS", "length": 497, "header": "sp|Q2T9V5-1|TRM6_BOVIN Isoform 1 of tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 OS=Bos taurus OX=9913 GN=TRMT6 PE=2 SV=1 CANONICAL=Q2T9V5-1" }, "isoforms": [ { "isoform_ac": "Q2T9V5-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9V5/entry#Q2T9V5-1", "sequence": { "sequence": "MESSEDQPGPQPQYPGNHCIRDGDFVVLKREDVFKAVQVQRRKKVTFEKQWFYLDNIIGHSYGTTFEVTNGGSLQPKKKKEEPTSETKEAGTDNRNIIDDGKSQKLTQDDIKALKDKGIKGEEIVQQLIENSTTFRDKTEFAQDKYIKKKKKKYEAMITVVKPSTRILSVMYYAREPGKINHMRYDTLAQMLTLGNIRAGNKMIVMETCAGLVLGAMMERMGGFGSIIQLYPGGGPVRAATACFGFPKSFLSGLYEFPLNKVDSLLNGTFSAEMLSSEPKDIASVEESNGTLEEKQTSEQENEDSIAEAPESNHPEEQERMEIVSQDPDYKEPKESGSKKDYIQEKQRRQEEQKKRHLEAAALLSERNADGLIVASRFHPTPLLLSLLDFVAPSRPFVVYCQYKEPLLECYTKLRERGGVINLRLSETWLRNYQVLPDRSHPKLLMSGGGGYLLSGFTVAMDNLKADPSLKSSTSTLESHKTEEPAAKKRKCPESDS", "length": 497, "header": "sp|Q2T9V5-1|TRM6_BOVIN Isoform 1 of tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 OS=Bos taurus OX=9913 GN=TRMT6 PE=2 SV=1 CANONICAL=Q2T9V5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 107, "end_pos": 107, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9V5", "url": "https://www.uniprot.org/uniprotkb/Q2T9V5" } ], "site_lbl": "Thr107" }, { "start_pos": 298, "end_pos": 298, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9V5", "url": "https://www.uniprot.org/uniprotkb/Q2T9V5" } ], "site_lbl": "Ser298" }, { "start_pos": 305, "end_pos": 305, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9V5", "url": "https://www.uniprot.org/uniprotkb/Q2T9V5" } ], "site_lbl": "Ser305" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505816", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505816", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z2L3-1", "protein_name": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "gene_name": "TRMT6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAVEWGLSPRICEGDCAVLKRGDVFKAVAVLRQRKIIFEKQGFYLDNAIGHVYGTTFEVTSDGNLQPKRQVEETTTETKEAGTDNRNIVDDGKSQKLTHDDIKALKDKGIKGQEIVQQLIENSTTFRDKTEFAQDKYIKKKKKKYEAVITIVKPSTRILSTMYYAREPGKIIHLRYDTLAQMLTLGNVRAGNKMIVMETCAGLVLGAVMERMGGYGSIIQMYPGGGPIRAATSCFGFPKPFFNNLHEFPLSKVDSLLCGTLSLETLPSEPEDTALTEEETNGLVDEKQTSVQGTEEESSAETAMEINQTEEQETMDINAEDAEFKENKERENKENVREKQRKQWERTKKLTEAAALLREKNADGLLVASKFHPTPLLLSLLEFVAPSRPFVVYCQYKEPLLECYTKLRERGGVVNLKLSETWLRSYQVLPDRSHPKLTMSGGGGYILSGITVVLDKGKSDSSNLEALKMEEPSSKRCKVQDLCC", "length": 484 }, "evidence": [ { "id": "Q2T9V5", "url": "https://omabrowser.org/oma/group/Q2T9V5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZVK3-1", "protein_name": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "gene_name": "Trmt6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELSAAEQPSPQPPHLGDHCIHDGDFVVLKREDVFKAVQVQRRKKVTFEKQWFYLDNAIGHSYGSTFEVSSGGSLQLRKKLEEPTSETKEAGTDNRNIVDDGKSQKLTQDDIKALKDKGIKGEEIVQQLIENSTTFRDKTEFAQDKYIKKKKKKYEAIITILKPSTRILSIMYYAREPGKINHMRYDTLAQMLTLGNIRAGNKMIVMETCSGLVLGAMMERMGGFGSIIQLYPGDGPVRAATACFGFPKSFLSGLHEFPLNKVKSLLNGTFSAEMLSSEPKDSTPVKESNGELEKEIAEQADKDSIADGPESNAEQNPVDIVPGDPESKEPKEKGSKRDYIQEKQRRQEEQRKRHMEAAALLGERNADGLIVASRFHPTPLLLSLLDFVAPSRPFVVYCQYKEPLLECYTKLRERGGVINLRLSETWLRNYQVLPDRSHPKLLMSGGGGYLLSGFTVVSDSHRVDPSLKSCASALDSPKTEEPAAKKQKCMESAS", "length": 495 }, "evidence": [ { "id": "Q2T9V5", "url": "https://omabrowser.org/oma/group/Q2T9V5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O80846-1", "protein_name": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "gene_name": "TRM6", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MELNKDQTVMSEDKKPQDPNPRFACEGCSVLLDINDGDRLVFARLSSGAILKIGNKNYSLKPLIGAPFGSLFQVETGEDGSFLSRILPIKQESNSNNVMDDSRDNREIVDNNEAQNLTGEEIEAMRREGAKGDEIIEALIANSKTFDKKFQLSQEKYKLKKQKKYAPKLLLRRPFARSICEAYFKKYPARIGFLRVDALSLLLTMANVTAYSDVLVVDMVGGLVTGAVAERLGGTGYVCNTYKGSSPYPVEMVRMFNFSDKVLKRIVQSSINELSSAKTASTEGNNQQEGVCKAENNINETATSDVMVEEISVTTEAGVVDIVVPESKIIKAAKAGAKASKETIEMWQENGFSSLIMAAQDQDPWIVAKDVLPLLSYSAPFAIYHQYLQPLATCMHKLQQGKMAINLQITEPWLREYQVLPSRSHPHMQMSSFGGYVLSGIRISTT", "length": 446 }, "evidence": [ { "id": "Q2T9V5", "url": "https://omabrowser.org/oma/group/Q2T9V5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P41814-1", "protein_name": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "gene_name": "GCD10", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MNALTTIDFNQHVIVRLPSKNYKIVELKPNTSVSLGKFGAFEVNDIIGYPFGLTFEIYYDGEEVSSDENRDSKPKNKIPIGKVRLLSQEIKDVNNDKDDGQSEPPLSIKEKSVSLELSSIDSSATNQNLVNMGSKAQELTVEEIEKMKQESLSSKEIIDKIIKSHKSFHNKTVYSQEKYVNRKKQKFAKYFTVEYLSSSNLLQFLIDKGDIQRVLDMSQESMGMLLNLANIQSEGNYLCMDETGGLLVYFLLERMFGGDNESKSKGKVIVIHENEHANLDLLKFANYSEKFIKEHVHTISLLDFFEPPTLQEIQSRFTPLPKEEARALKGGKKNSYYRKLRWYNTQWQILELTGEFLYDGLVMATTLHLPTLVPKLAEKIHGSRPIVCYGQFKETLLELAHTLYSDLRFLAPSILETRCRPYQSIRGKLHPLMTMKGGGGYLMWCHRVIPAPEPVSENATAADSSEKLAEHGAKKQKI", "length": 478 }, "evidence": [ { "id": "Q2T9V5", "url": "https://omabrowser.org/oma/group/Q2T9V5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54UB1-1", "protein_name": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit trm6", "gene_name": "trmt6", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "METETPMDVETKSTTSNTNDNNNNTTIVKTTSNIIKEGDHVILDINNGEKFSVIKVKLGSKVKIGKKQILINSIIGESYYSSFQVSNEKNTLERITQKEIDDRLNNLVELNQNDADNRNLDQNNTAQKLTQEDINEMKQKGTDSNTIIKTIVENSESFKTKTSFSQIKYLKKKIKKYSTIVKIIKPTLKSLTEAYYKKDSRKICGLRFDSFGQLLTLGNIRANSQVLVVETCMGLVTGSIAERMNGQGTILSAYIGKGPSLSIVNNFGFNTDVLNTIYPFNLNITSVLNKGEDISKLPPTASSGIYDKQVKEKEKEKEKDENVKDEKESGEEAKTIINQRNDTSNENIVKLLKDGGVWSLVIVTKYSPLNILLSCWPYLNSSGSFVIYSQFPQPLMEVHQFLHKNQMAVNQQISEIWMREHQVLPKRTHPMMGMDGASGFILYGTKVTKPIQKSTTTTTTTTTTTTNNSINPTKTTASLDIENKVIDATTSSSSSSTAAATTTEEDKEDSESALKKRKIDE", "length": 521 }, "evidence": [ { "id": "Q2T9V5", "url": "https://omabrowser.org/oma/group/Q2T9V5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8CE96-1", "protein_name": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "gene_name": "Trmt6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEASAAEQPSSPPPPLGDHCIHDGDFVVLKREDVFKAVQVQRRKKVTFEKQWFYLDNAIGHSYGSAFDVSSGGSLQLRKKLEEPASETKEAGTDNRNIVDDGKSQKLTQDDIKALKDKGIKGEEIVQQLIENSTTFRDKTEFAQDKYIKKKKKKYEAIVTILKPSTRILSIMYYAREPGKINHMRYDTLAQMLTLGNIRAGNKMIVMETCSGLVLGAMMERMGGFGSIIQLYPGDGPVRAATACFGFPKSFLSGLYEFPLNKVNSLLNGTFSAEMLSSEPKDSTPVEESNGELEEKEIAEQADEDNIVDAAENNSGEQRPMEIVPGDPENKEPKEKRSKRDYIQEKQRRQEEQRKRHLEAAALLGERNADGLIVASRFHPTPLLLSLLDFVAPSRPFVVYCQYKEPLLECYTKLRERGGVINLRLSETWLRNYQVLPDRSHPKLLMSGGGGYLLSGFTVVSDSLRADPSLKSCTGALDPHKAEEPAAKKQKCMESAS", "length": 497 }, "evidence": [ { "id": "Q2T9V5", "url": "https://omabrowser.org/oma/group/Q2T9V5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UJA5-1", "protein_name": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "gene_name": "TRMT6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGSGEQPGPQPQHPGDHRIRDGDFVVLKREDVFKAVQVQRRKKVTFEKQWFYLDNVIGHSYGTAFEVTSGGSLQPKKKREEPTAETKEAGTDNRNIVDDGKSQKLTQDDIKALKDKGIKGEEIVQQLIENSTTFRDKTEFAQDKYIKKKKKKYEAIITVVKPSTRILSIMYYAREPGKINHMRYDTLAQMLTLGNIRAGNKMIVMETCAGLVLGAMMERMGGFGSIIQLYPGGGPVRAATACFGFPKSFLSGLYEFPLNKVDSLLHGTFSAKMLSSEPKDSALVEESNGTLEEKQASEQENEDSMAEAPESNHPEDQETMETISQDPEHKGPKERGSKKDYIQEKQRRQEEQRKRHLEAAALLSERNADGLIVASRFHPTPLLLSLLDFVAPSRPFVVYCQYKEPLLECYTKLRERGGVINLRLSETWLRNYQVLPDRSHPKLLMSGGGGYLLSGFTVAMDNLKADTSLKSNASTLESHETEEPAAKKRKCPESDS", "length": 497 }, "evidence": [ { "id": "Q2T9V5", "url": "https://omabrowser.org/oma/group/Q2T9V5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2T9V5", "url": "https://www.uniprot.org/uniprotkb/Q2T9V5" } ], "pmid": "" }, { "name": "tRNA (m1A) methyltransferase complex", "id": "GO:0031515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031515", "evidence": [ { "database": "UniProtKB", "id": "Q2T9V5", "url": "https://www.uniprot.org/uniprotkb/Q2T9V5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "Q2T9V5", "url": "https://www.uniprot.org/uniprotkb/Q2T9V5" } ], "pmid": "" }, { "name": "tRNA methylation", "id": "GO:0030488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030488", "evidence": [ { "database": "UniProtKB", "id": "Q2T9V5", "url": "https://www.uniprot.org/uniprotkb/Q2T9V5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 131, "end_pos": 133, "annotation": "n_glycosylation_sequon" }, { "start_pos": 267, "end_pos": 269, "annotation": "n_glycosylation_sequon" }, { "start_pos": 289, "end_pos": 291, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9V5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 497, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9V5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9V5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 107, 298, 305 ], "sequon_annotation_sites": [ { "start_pos": 131, "end_pos": 133 }, { "start_pos": 267, "end_pos": 269 }, { "start_pos": 289, "end_pos": 291 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9W0-1", "uniprot_ac": "Q2T9W0", "uniprot_id": "BACD1_BOVIN", "mass": { "chemical_mass": 36425.0, "monoisotopic_mass": 36425.0 }, "refseq": { "ac": "NP_001033146", "name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033146" }, "gene_names": [ { "name": "KCTD13", "type": "recommended", "evidence": [ { "id": "Q2T9W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W0" } ] }, { "name": "KCTD13", "type": "synonym", "evidence": [ { "id": "NP_001033146", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033146" } ] } ], "protein_names": [ { "name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1", "type": "recommended", "evidence": [ { "id": "Q2T9W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W0/entry#names_and_taxonomy" } ] }, { "name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1", "type": "synonym", "evidence": [ { "id": "NP_001033146", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033146" } ] }, { "name": "BTB/POZ domain-containing protein KCTD13", "type": "synonym", "evidence": [ { "id": "NP_001033146", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033146" }, { "id": "Q2T9W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W0/entry#names_and_taxonomy" } ] }, { "name": "potassium channel tetramerisation domain containing 13", "type": "synonym", "evidence": [ { "id": "NP_001033146", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033146" } ] } ], "function": [ { "annotation": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission.", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W0", "url": "https://www.uniprot.org/uniprotkb/Q2T9W0#function" }, { "database": "UniProtKB", "id": "Q8BGV7", "url": "https://www.uniprot.org/uniprotkb/Q8BGV7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9W0", "url": "https://www.uniprot.org/uniprotkb/Q2T9W0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCTD13", "url": "https://www.uniprot.org/uniprotkb/Q2T9W0", "locus": { "chromosome": "25", "start_pos": 26356561, "end_pos": 26343322, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015982", "url": "https://www.ensembl.org/id/ENSBTAG00000015982" } ] } } ], "crossref": [ { "id": "Q2T9W0", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9W0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd18400", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18400", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507911", "url": "https://www.ncbi.nlm.nih.gov/gene/507911", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045068", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045068", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507911", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507911", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9W0", "url": "https://www.orthodb.org/?gene=Q2T9W0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11145", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11145", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11145:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11145:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033146", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9W0", "url": "https://www.uniprot.org/uniprotkb/Q2T9W0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9W0-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9W0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAEASGPAAAEAPSLEVAKPSELEPGSAAYGLKPLTTNSKYVKLNVGGSLHYTTLRTLTGQDTRLKAMFSGRAEVLTDAGGWVLIDRSGRHFGTILNYLRDGSVPLPESTRELGELLGEARHYLVQGLIEDCQLALQQKRENVSPLCLIPTVTSPREEQQLLASTSKPVVKLLHNRSNNKYSYTSTSDDNLLKNIELFDKLALRFHGRLLFLKDVLGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIFEETLNILIYETPRGPDPALLEATGGAAGGGGASRGEDEDNREHRVRRIHVRRHITHDERPHGQQIVFKD", "length": 329, "header": "sp|Q2T9W0-1|BACD1_BOVIN Isoform 1 of BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 OS=Bos taurus OX=9913 GN=KCTD13 PE=2 SV=1 CANONICAL=Q2T9W0-1" }, "isoforms": [ { "isoform_ac": "Q2T9W0-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9W0/entry#Q2T9W0-1", "sequence": { "sequence": "MSAEASGPAAAEAPSLEVAKPSELEPGSAAYGLKPLTTNSKYVKLNVGGSLHYTTLRTLTGQDTRLKAMFSGRAEVLTDAGGWVLIDRSGRHFGTILNYLRDGSVPLPESTRELGELLGEARHYLVQGLIEDCQLALQQKRENVSPLCLIPTVTSPREEQQLLASTSKPVVKLLHNRSNNKYSYTSTSDDNLLKNIELFDKLALRFHGRLLFLKDVLGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIFEETLNILIYETPRGPDPALLEATGGAAGGGGASRGEDEDNREHRVRRIHVRRHITHDERPHGQQIVFKD", "length": 329, "header": "sp|Q2T9W0-1|BACD1_BOVIN Isoform 1 of BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 OS=Bos taurus OX=9913 GN=KCTD13 PE=2 SV=1 CANONICAL=Q2T9W0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507911", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507911", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W0", "url": "https://www.uniprot.org/uniprotkb/Q2T9W0" } ], "pmid": "" }, { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W0", "url": "https://www.uniprot.org/uniprotkb/Q2T9W0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W0", "url": "https://www.uniprot.org/uniprotkb/Q2T9W0" } ], "pmid": "" }, { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W0", "url": "https://www.uniprot.org/uniprotkb/Q2T9W0" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W0", "url": "https://www.uniprot.org/uniprotkb/Q2T9W0" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W0", "url": "https://www.uniprot.org/uniprotkb/Q2T9W0" } ], "pmid": "" }, { "name": "negative regulation of Rho protein signal transduction", "id": "GO:0035024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035024", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W0", "url": "https://www.uniprot.org/uniprotkb/Q2T9W0" } ], "pmid": "" }, { "name": "stress fiber assembly", "id": "GO:0043149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043149", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W0", "url": "https://www.uniprot.org/uniprotkb/Q2T9W0" } ], "pmid": "" }, { "name": "positive regulation of synaptic transmission", "id": "GO:0050806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050806", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W0", "url": "https://www.uniprot.org/uniprotkb/Q2T9W0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 143, "end_pos": 145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9W0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 329, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9W0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9W0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 143, "end_pos": 145 }, { "start_pos": 176, "end_pos": 178 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9W2-1", "uniprot_ac": "Q2T9W2", "uniprot_id": "THUM3_BOVIN", "mass": { "chemical_mass": 56674.0, "monoisotopic_mass": 56674.0 }, "refseq": { "ac": "NP_001033151", "name": "tRNA (guanine(6)-N(2))-methyltransferase THUMP3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033151" }, "gene_names": [ { "name": "THUMPD3", "type": "recommended", "evidence": [ { "id": "Q2T9W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2" } ] }, { "name": "THUMPD3", "type": "synonym", "evidence": [ { "id": "NP_001033151", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033151" } ] } ], "protein_names": [ { "name": "tRNA (guanine(6)-N(2))-methyltransferase THUMP3", "type": "recommended", "evidence": [ { "id": "Q2T9W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.-", "type": "synonym", "evidence": [ { "id": "Q2T9W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.256", "type": "synonym", "evidence": [ { "id": "Q2T9W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2/entry#names_and_taxonomy" } ] }, { "name": "THUMP domain-containing protein 3", "type": "synonym", "evidence": [ { "id": "NP_001033151", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033151" }, { "id": "Q2T9W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2/entry#names_and_taxonomy" } ] }, { "name": "tRNA (guanine(6)-N(2))-methyltransferase THUMP3", "type": "synonym", "evidence": [ { "id": "NP_001033151", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033151" } ] }, { "name": "tRNA (guanine(6)-N2)-methyltransferase THUMP3", "type": "synonym", "evidence": [ { "id": "NP_001033151", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033151" } ] }, { "name": "tRNA(Trp) (guanine(7)-N(2))-methyltransferase THUMP3", "type": "synonym", "evidence": [ { "id": "NP_001033151", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033151" }, { "id": "Q2T9W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalytic subunit of the THUMPD3-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 6 (m2G6) in tRNAs. This is one of the major tRNA (guanine-N(2))-methyltransferases. Also catalyzes the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 7 of tRNA(Trp).", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W2", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2#function" }, { "database": "UniProtKB", "id": "Q9BV44", "url": "https://www.uniprot.org/uniprotkb/Q9BV44#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9W2", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "THUMPD3", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2", "locus": { "chromosome": "22", "start_pos": 17218557, "end_pos": 17239214, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003112", "url": "https://www.ensembl.org/id/ENSBTAG00000003112" } ] } } ], "crossref": [ { "id": "Q2T9W2", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9W2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd11715", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11715", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508940", "url": "https://www.ncbi.nlm.nih.gov/gene/508940", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000241", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000241", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508940", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508940", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9W2", "url": "https://www.orthodb.org/?gene=Q2T9W2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14911", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14911", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14911:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14911:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01170", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01170", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02926", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02926", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033151", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "51116", "url": "https://www.rhea-db.org/rhea/51116", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "83419", "url": "https://www.rhea-db.org/rhea/83419", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9W2", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9W2-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDVQEATNQLLDVNLCENQMSIQVTESGPRSESEHLQVTIGATVPTGFEQTAADEVREKLGSSCKISKDRGKIYFDITVDSLAQVHCLRSVDNLFVVVQEFKDYQFKETKEEVLKDFEELAGKLPWSDPLKIWKINTCFKKKKTKRRKLNPNSSKQKIDNGRGDTTVEKDVKKELTNSVSDSQISDYYENPAIKEQVSTLIGDGLTSCKDETEENSKEEADPEVLKFRVTCNRAGEKHCFSSNEAARDFGGAVQDYFKWKADMTNFDVEVLLNIHDNEVVVGIALTEESLHRRNITHFGPTTLRSTLAYGMLRLCAPQPTDIIVDPMCGTGAIPIEGATEWSNCYHIAGDNNPLAVNRAANNISSLLTKIQVKEGKLPLGLPIDTIQWDICNLPLRTGSVDIIVTDMPFGKRMGSKKRNWNLYPACLREMSRVCRPGTGRAVLLTQDKKCFAKALSGMGHLWRKVHTVWVNIGGLHAAVYLLKRTPQSFVHPSEEDGERCPCTQR", "length": 506, "header": "sp|Q2T9W2-1|THUM3_BOVIN Isoform 1 of tRNA (guanine(6)-N(2))-methyltransferase THUMP3 OS=Bos taurus OX=9913 GN=THUMPD3 PE=2 SV=1 CANONICAL=Q2T9W2-1" }, "isoforms": [ { "isoform_ac": "Q2T9W2-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2/entry#Q2T9W2-1", "sequence": { "sequence": "MSDVQEATNQLLDVNLCENQMSIQVTESGPRSESEHLQVTIGATVPTGFEQTAADEVREKLGSSCKISKDRGKIYFDITVDSLAQVHCLRSVDNLFVVVQEFKDYQFKETKEEVLKDFEELAGKLPWSDPLKIWKINTCFKKKKTKRRKLNPNSSKQKIDNGRGDTTVEKDVKKELTNSVSDSQISDYYENPAIKEQVSTLIGDGLTSCKDETEENSKEEADPEVLKFRVTCNRAGEKHCFSSNEAARDFGGAVQDYFKWKADMTNFDVEVLLNIHDNEVVVGIALTEESLHRRNITHFGPTTLRSTLAYGMLRLCAPQPTDIIVDPMCGTGAIPIEGATEWSNCYHIAGDNNPLAVNRAANNISSLLTKIQVKEGKLPLGLPIDTIQWDICNLPLRTGSVDIIVTDMPFGKRMGSKKRNWNLYPACLREMSRVCRPGTGRAVLLTQDKKCFAKALSGMGHLWRKVHTVWVNIGGLHAAVYLLKRTPQSFVHPSEEDGERCPCTQR", "length": 506, "header": "sp|Q2T9W2-1|THUM3_BOVIN Isoform 1 of tRNA (guanine(6)-N(2))-methyltransferase THUMP3 OS=Bos taurus OX=9913 GN=THUMPD3 PE=2 SV=1 CANONICAL=Q2T9W2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W2", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:508940", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508940", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "tRNA (guanine) methyltransferase activity", "id": "GO:0016423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016423", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W2", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2" } ], "pmid": "" }, { "name": "tRNA binding", "id": "GO:0000049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W2", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2" } ], "pmid": "" }, { "name": "tRNA (guanine(6)-N2)-methyltransferase activity", "id": "GO:0160117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160117", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W2", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W2", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2" } ], "pmid": "" }, { "name": "tRNA methyltransferase complex", "id": "GO:0043527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043527", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W2", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "tRNA methylation", "id": "GO:0030488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030488", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W2", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 153, "end_pos": 155, "annotation": "n_glycosylation_sequon" }, { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" }, { "start_pos": 363, "end_pos": 365, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "51116", "name": "", "equation": "guanosine(6) in tRNA + S-adenosyl-L-methionine = N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2T9W2-1" ], "evidence": [ { "id": "51116", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/51116" } ] }, { "id": "83419", "name": "", "equation": "guanosine(7) in tRNA + S-adenosyl-L-methionine = N(2)-methylguanosine(7) in tRNA + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2T9W2-1", "F1N027-1" ], "evidence": [ { "id": "83419", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/83419" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1N027", "gene_name": "THUMPD3", "activity": [ { "ec_number": "2.1.1.256", "activity": "guanosine(6) in tRNA + S-adenosyl-L-methionine = N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "F1N027", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N027" } ] }, { "ec_number": "2.1.1.256", "activity": "", "evidence": [ { "id": "F1N027", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N027" } ] } ] }, { "uniprot_ac": "Q2T9W2", "gene_name": "THUMPD3", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q2T9W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2" } ] }, { "ec_number": "2.1.1.256", "activity": "guanosine(6) in tRNA + S-adenosyl-L-methionine = N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "Q2T9W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2" } ] }, { "ec_number": "2.1.1.256", "activity": "", "evidence": [ { "id": "Q2T9W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9W2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 506, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9W2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9W2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2T9W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W2" }, { "id": "PRU00529", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00529" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "THUMP", "eco_id": "ECO_0000255", "start_pos": 170, "end_pos": 286, "start_aa": "Lys", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.1.1.256", "ec_name": "guanosine(6) in tRNA + S-adenosyl-L-methionine = N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "2.1.1.256", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.256" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 153, "end_pos": 155 }, { "start_pos": 295, "end_pos": 297 }, { "start_pos": 363, "end_pos": 365 } ] }, 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"publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2T9W4-1", "uniprot_ac": "Q2T9W4", "uniprot_id": "ACTL9_BOVIN", "mass": { "chemical_mass": 45566.0, "monoisotopic_mass": 45566.0 }, "refseq": { "ac": "NP_001033658", "name": "actin-like protein 9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033658" }, "gene_names": [ { "name": "ACTL9", "type": "recommended", "evidence": [ { "id": "Q2T9W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W4" } ] }, { "name": "ACTL7C", "type": "synonym", "evidence": [ { "id": "Q2T9W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W4" } ] }, { "name": "ACTL9", "type": "synonym", "evidence": [ { "id": "NP_001033658", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033658" } ] } ], "protein_names": [ { "name": "Actin-like protein 9", "type": "recommended", "evidence": [ { "id": "Q2T9W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9W4/entry#names_and_taxonomy" } ] }, { "name": "actin-like protein 9", "type": "synonym", "evidence": [ { "id": "NP_001033658", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033658" } ] } ], "function": [ { "annotation": "Testis-specic protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation.", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W4", "url": "https://www.uniprot.org/uniprotkb/Q2T9W4#function" }, { "database": "UniProtKB", "id": "Q8TC94", "url": "https://www.uniprot.org/uniprotkb/Q8TC94#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9W4", "url": "https://www.uniprot.org/uniprotkb/Q2T9W4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACTL9", "url": "https://www.uniprot.org/uniprotkb/Q2T9W4", "locus": { "chromosome": "7", "start_pos": 17250902, "end_pos": 17252340, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011255", "url": "https://www.ensembl.org/id/ENSBTAG00000011255" } ] } } ], "crossref": [ { "id": "Q2T9W4", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9W4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011255", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011255", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540051", "url": "https://www.ncbi.nlm.nih.gov/gene/540051", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540051", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540051", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HATERMD", "url": "https://omabrowser.org/oma/group/HATERMD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2T9W4", "url": "https://www.orthodb.org/?gene=Q2T9W4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11937", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11937", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00022", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00022", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033658", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9W4", "url": "https://www.uniprot.org/uniprotkb/Q2T9W4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9W4-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9W4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPNQGNPLEPQDSPEIPKPSLNLSSILAKSTLPQEPPSMVGDRLPPKTGAVVIDMGTGTCKVGFAGQARPTYTVATIVGCQPQKPATSGQPVMETFIGEAARKRPELTLVQPVHSGIVVDWDAAELIWRHMLEHDLRVATRDHPLLFSDPPFSPSTNREKLVEVAFESLSSPAMYVASQSVLSVYAHGRVSGLVVDTGHGVTYTVPVFQGYNLPHATQRLDLAGTHLTAFLAEMLLGSGLPLGQQDLDTVENIKHRYCYVAPDFLKEQARPELECRQTLKLPDGRTVTLGKELFQCPELLFSPPEIPGLSPVGVPTMAQQSLSKVAAELRTDLAQNVLLCGGSSLFTGFQARFQTELLRNLPPEAHVVVMAQPTRNFSVWIGGSILASLRTFQSCWVLREQYEEQGPYIVYRKCY", "length": 416, "header": "sp|Q2T9W4-1|ACTL9_BOVIN Isoform 1 of Actin-like protein 9 OS=Bos taurus OX=9913 GN=ACTL9 PE=2 SV=1 CANONICAL=Q2T9W4-1" }, "isoforms": [ { "isoform_ac": "Q2T9W4-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9W4/entry#Q2T9W4-1", "sequence": { "sequence": "MDPNQGNPLEPQDSPEIPKPSLNLSSILAKSTLPQEPPSMVGDRLPPKTGAVVIDMGTGTCKVGFAGQARPTYTVATIVGCQPQKPATSGQPVMETFIGEAARKRPELTLVQPVHSGIVVDWDAAELIWRHMLEHDLRVATRDHPLLFSDPPFSPSTNREKLVEVAFESLSSPAMYVASQSVLSVYAHGRVSGLVVDTGHGVTYTVPVFQGYNLPHATQRLDLAGTHLTAFLAEMLLGSGLPLGQQDLDTVENIKHRYCYVAPDFLKEQARPELECRQTLKLPDGRTVTLGKELFQCPELLFSPPEIPGLSPVGVPTMAQQSLSKVAAELRTDLAQNVLLCGGSSLFTGFQARFQTELLRNLPPEAHVVVMAQPTRNFSVWIGGSILASLRTFQSCWVLREQYEEQGPYIVYRKCY", "length": 416, "header": "sp|Q2T9W4-1|ACTL9_BOVIN Isoform 1 of Actin-like protein 9 OS=Bos taurus OX=9913 GN=ACTL9 PE=2 SV=1 CANONICAL=Q2T9W4-1" }, "locus": { "chromosome": "7", "start_pos": 17252226, "end_pos": 17250979, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014947.3", "url": "https://www.ensembl.org/id/ENSBTAT00000014947.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014947.2", "url": "https://www.ensembl.org/id/ENSBTAP00000014947.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540051", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540051", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B3DMA6-1", "protein_name": "Actin-like 9", "gene_name": "Actl9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDVNGYPKPQPSPETHGPPSLTSNTVLVSKNLEQDSFSVVGDRFPLKTGAVVIDMGTGTCKVGFAGQSQPTYSVATILGCQPKKQATKGQSELETFIGEAARSRPELRLVKPIRNGIVVDWEAAELIWRHILEHDLRVATQEHPLLFSDPPFSPATNREKLVEVAFESLHSPALYVASQSVLSVYAHGRVNGLVVDTGHGVSYTVPVVQGYNLPHAIQRLDLAGNHLTAFLAEMILGSGFSLQQEDLDLVENIKHHYCYLASDFQKEQARPDQECKQTLRLPDGRTVTLGKELFQCPELLFHPPEIPGLSPMGLPAMAEQSLLRVPQDLRPHVAQNVILCGGSSLFTGLESRFRAELLRSLSPEDHVVVMAQPNRNLSVWIGGSILASLHAFQSCWVLREQYEEMGPQILLSYILIAVAPPSTRSASPLPLPFGSTPFLYPIRKEEAFQSTVIERLPRAASGSRYKDQRPSFR", "length": 473 }, "evidence": [ { "id": "Q2T9W4", "url": "https://omabrowser.org/oma/group/Q2T9W4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SA46-1", "protein_name": "Actin like 9", "gene_name": "ACTL9", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDPNHSNFLEPQPSPEALKPTLNPSSLVVNKTQPQDAPSLVGDRLPPKTGAVVIDMGTGTCKVGFSGQARPTYTVATIVGCQPKKPASNGQPVLETFIGEAARTRPELTLVQPVRNGIVVDWDAAELIWRHMLEHDLRVATRDHPLLFSDPPFSPTTNREKLVEVVFESLNSPAMYVASQSVLSVYAHGRVSGLVVDTGHGVTYTVPVFQGYNLPHATERLDLAGTHLTAFLAEMLQGSGLPLGQQDLDAVENIKHRYCYVAPDFVKEQARPELECRQTLKLPDGRTVTLGKELFRCPELLFSPPEIPGLSPVGIPTMAAQSLHKVPLEVRTDVAQNVLLCGGSSLFTGFEGRFRTELLRSLSSEPHMVVTAQPTRNFSVWIGGSILASLRAFQSCWVLREQYEEQGPHIVYRKCY", "length": 416 }, "evidence": [ { "id": "Q2T9W4", "url": "https://omabrowser.org/oma/group/Q2T9W4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8CG27-1", "protein_name": "Actin-like protein 9", "gene_name": "Actl9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDVNGHPKFQPSPETDGPLPLTSSTLMVSKSLQQDSLSMVGDRLPPKTGAVVIDMGTGTCKVGFAGQSQPTYTVATILGCQPKKQATKDQSELETFIGEAARSRPELRLVKPIRNGIVVDWEAAELIWRHILEHDLQVATHEHPLLFSDPPFSPATNREKLVEVAFESLHSPALYVASQSVLSVYAHGRVNGLVVDTGHGVSYTVPVVQGYNLPHAIQRLDLAGNHLTAFLAEMLLGSGFSLQQEDLDLVENIKHHYCYLAPDFQKEQARPDEECKQSLKLPDGRTVTLGKELFQCPELLFHPPEIPGLSPIGLPAMAEQSLLKVPQELRPHVARNVILCGGSSLFTGLEGRFRAELLHSLSPEDHVVVMAHPNRNLSVWIGGSILASLHAFQSCWVLREQYEERGPQVVYRKCY", "length": 415 }, "evidence": [ { "id": "Q2T9W4", "url": "https://omabrowser.org/oma/group/Q2T9W4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TC94-1", "protein_name": "Actin-like protein 9", "gene_name": "ACTL9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDASRPKSSESQSSLEAPRPGPNPSPNVVNKPLQRDSPGMVADRLPPKTGAVVIDMGTGTCKVGFAGQASPTYTVATILGCQPKKPATSGQSGLQTFIGEAARVLPELTLVQPLRSGIVVDWDAAELIWRHLLEHDLRVATHDHPLLFSDPPFSPATNREKLVEVAFESLRSPAMYVASQSVLSVYAHGRVSGLVVDTGHGVTYTVPVFQGYNLLHATERLDLAGNNLTAFLAEMLLQAGLPLGQQDLDLVENIKHHYCYVASDFQKEQARPEQEYKRTLKLPDGRTVTLGKELFQCPELLFNPPEVPGLSPVGLSTMAKQSLRKLSLEMRADLAQNVLLCGGSSLFTGFEGRFRAELLRALPAETHVVVAAQPTRNFSVWIGGSILASLRAFQSCWVLREQYEEQGPYIVYRKCY", "length": 416 }, "evidence": [ { "id": "Q2T9W4", "url": "https://omabrowser.org/oma/group/Q2T9W4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "sperm head", "id": "GO:0061827", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061827", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W4", "url": "https://www.uniprot.org/uniprotkb/Q2T9W4" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W4", "url": "https://www.uniprot.org/uniprotkb/Q2T9W4" } ], "pmid": "" }, { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W4", "url": "https://www.uniprot.org/uniprotkb/Q2T9W4" } ], "pmid": "" }, { "name": "perinuclear theca", "id": "GO:0033011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033011", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W4", "url": "https://www.uniprot.org/uniprotkb/Q2T9W4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of cytoskeleton", "id": "GO:0005200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005200", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W4", "url": "https://www.uniprot.org/uniprotkb/Q2T9W4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "fertilization", "id": "GO:0009566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009566", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W4", "url": "https://www.uniprot.org/uniprotkb/Q2T9W4" } ], "pmid": "" }, { "name": "single fertilization", "id": "GO:0007338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007338", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W4", "url": "https://www.uniprot.org/uniprotkb/Q2T9W4" } ], "pmid": "" }, { "name": "acrosome assembly", "id": "GO:0001675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001675", "evidence": [ { "database": "UniProtKB", "id": "Q2T9W4", "url": "https://www.uniprot.org/uniprotkb/Q2T9W4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 23, "end_pos": 25, "annotation": "n_glycosylation_sequon" }, { "start_pos": 377, "end_pos": 379, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9W4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 416, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9W4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9W4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 23, "end_pos": 25 }, { "start_pos": 377, "end_pos": 379 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9X1-1", "uniprot_ac": "Q2T9X1", "uniprot_id": "RPC8_BOVIN", "mass": { "chemical_mass": 23027.0, "monoisotopic_mass": 23027.0 }, "refseq": { "ac": "NP_001070430", "name": "DNA-directed RNA polymerase III subunit RPC8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070430" }, "gene_names": [ { "name": "POLR3H", "type": "recommended", "evidence": [ { "id": "Q2T9X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X1" } ] }, { "name": "POLR3H", "type": "synonym", "evidence": [ { "id": "NP_001070430", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070430" } ] } ], "protein_names": [ { "name": "DNA-directed RNA polymerase III subunit RPC8", "type": "recommended", "evidence": [ { "id": "Q2T9X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X1/entry#names_and_taxonomy" } ] }, { "name": "DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide", "type": "synonym", "evidence": [ { "id": "NP_001070430", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070430" }, { "id": "Q2T9X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X1/entry#names_and_taxonomy" } ] }, { "name": "DNA-directed RNA polymerase III subunit H", "type": "synonym", "evidence": [ { "id": "NP_001070430", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070430" }, { "id": "Q2T9X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X1/entry#names_and_taxonomy" } ] }, { "name": "DNA-directed RNA polymerase III subunit RPC8", "type": "synonym", "evidence": [ { "id": "NP_001070430", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070430" } ] }, { "name": "RNA polymerase III subunit C8", "type": "synonym", "evidence": [ { "id": "NP_001070430", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070430" }, { "id": "Q2T9X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X1/entry#names_and_taxonomy" } ] }, { "name": "polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)", "type": "synonym", "evidence": [ { "id": "NP_001070430", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070430" } ] } ], "function": [ { "annotation": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With CRCP/RPC9 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2T9X1", "url": "https://www.uniprot.org/uniprotkb/Q2T9X1#function" }, { "database": "UniProtKB", "id": "Q9Y535", "url": "https://www.uniprot.org/uniprotkb/Q9Y535#function" }, { "database": "UniProtKB", "id": "O94285", "url": "https://www.uniprot.org/uniprotkb/O94285#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9X1", "url": "https://www.uniprot.org/uniprotkb/Q2T9X1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "POLR3H", "url": "https://www.uniprot.org/uniprotkb/Q2T9X1", "locus": { "chromosome": "5", "start_pos": 112617058, "end_pos": 112635775, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005311", "url": "https://www.ensembl.org/id/ENSBTAG00000005311" } ] } } ], "crossref": [ { "id": "Q2T9X1", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9X1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04330", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04330", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "767843", "url": "https://www.ncbi.nlm.nih.gov/gene/767843", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005576", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005576", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013238", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013238", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045113", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045113", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767843", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767843", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9X1", "url": "https://www.orthodb.org/?gene=Q2T9X1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12709", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12709", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12709:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12709:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03876", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03876", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08292", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08292", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070430", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9X1", "url": "https://www.uniprot.org/uniprotkb/Q2T9X1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9X1-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9X1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFVLVEMVDTVRIPPWQFERKLNDSIDEELNKKLANKVMYNVGLCICLFDITKLEDAYVFPGDGASHTKVHFRYVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLQQPAKFDEAEQVWVWEYETEEGAHDLYMDIGEEVRFRVVDESFVDTSPTGPSSAEAASSSEELPKKEAPYTLMGSISEPGLGLLSWWTSS", "length": 204, "header": "sp|Q2T9X1-1|RPC8_BOVIN Isoform 1 of DNA-directed RNA polymerase III subunit RPC8 OS=Bos taurus OX=9913 GN=POLR3H PE=2 SV=1 CANONICAL=Q2T9X1-1" }, "isoforms": [ { "isoform_ac": "Q2T9X1-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9X1/entry#Q2T9X1-1", "sequence": { "sequence": "MFVLVEMVDTVRIPPWQFERKLNDSIDEELNKKLANKVMYNVGLCICLFDITKLEDAYVFPGDGASHTKVHFRYVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLQQPAKFDEAEQVWVWEYETEEGAHDLYMDIGEEVRFRVVDESFVDTSPTGPSSAEAASSSEELPKKEAPYTLMGSISEPGLGLLSWWTSS", "length": 204, "header": "sp|Q2T9X1-1|RPC8_BOVIN Isoform 1 of DNA-directed RNA polymerase III subunit RPC8 OS=Bos taurus OX=9913 GN=POLR3H PE=2 SV=1 CANONICAL=Q2T9X1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], 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"https://www.uniprot.org/uniprotkb/Q2T9X1" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "Q2T9X1", "url": "https://www.uniprot.org/uniprotkb/Q2T9X1" } ], "pmid": "" }, { "name": "transcription initiation at RNA polymerase III promoter", "id": "GO:0006384", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006384", "evidence": [ { "database": "UniProtKB", "id": "Q2T9X1", "url": "https://www.uniprot.org/uniprotkb/Q2T9X1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "RNA polymerase III complex", "id": "GO:0005666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005666", "evidence": [ { "database": "UniProtKB", "id": "Q2T9X1", "url": "https://www.uniprot.org/uniprotkb/Q2T9X1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 23, "end_pos": 25, "annotation": 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"name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613336", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q2T9X2", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q2T9X2", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ], "pmid": "" }, { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "Q2T9X2", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": 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"https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { 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"Q2T9Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Y6/entry#names_and_taxonomy" } ] }, { "name": "gamma-ECS regulatory subunit", "type": "synonym", "evidence": [ { "id": "NP_001033232", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033232" } ] }, { "name": "gamma-glutamylcysteine synthetase regulatory subunit", "type": "synonym", "evidence": [ { "id": "NP_001033232", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033232" } ] }, { "name": "glutamate--cysteine ligase regulatory subunit", "type": "synonym", "evidence": [ { "id": "NP_001033232", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033232" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2T9Y6", "url": "https://www.uniprot.org/uniprotkb/Q2T9Y6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GCLM", "url": "https://www.uniprot.org/uniprotkb/Q2T9Y6", "locus": { "chromosome": "3", "start_pos": 49599562, "end_pos": 49581839, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007842", "url": "https://www.ensembl.org/id/ENSBTAG00000007842" } ] } } ], "crossref": [ { "id": "Q2T9Y6", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9Y6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007842", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007842", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "525659", "url": "https://www.ncbi.nlm.nih.gov/gene/525659", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR023210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032963", "url": 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[ "Protein Classification" ] }, { "id": "PF00248", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00248", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-174403", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174403", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001033232", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033232", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NQQ8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYJ5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9Y6", "url": "https://www.uniprot.org/uniprotkb/Q2T9Y6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9Y6-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Y6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTDSRAAGALLARASTLHLQTGNLLNWGRLRKKCPSTHSEELRDCIQKTLNEWSSQISPDLIREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVGSNSSSSTRNAVDMACSVLGVAQLDSVIIASPPVEDGVNLSLEHLQPYWEELQNLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIRAHEWVPLWLLRYSVIVKSRGIIKSKGYILQAKRKGS", "length": 274, "header": "sp|Q2T9Y6-1|GSH0_BOVIN Isoform 1 of Glutamate--cysteine ligase regulatory subunit OS=Bos taurus OX=9913 GN=GCLM PE=2 SV=1 CANONICAL=Q2T9Y6-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NQQ8-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Y6/entry#A0ABI0NQQ8-1", "sequence": { "sequence": "MGTDSRAAGALLARASTLHLQTGNLLNWGRLRKKCPSTHSEEEFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVGSNSSSSTRNAVDMACSVLGVAQLDSVIIASPPVEDGVNLSLEHLQPYWEELQNLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIRAHEWVPLWLLRYSVIVKSRGIIKSKGYILQAKRKGS", "length": 252, "header": "tr|A0ABI0NQQ8-1|A0ABI0NQQ8_BOVIN Computationally mapped isoform of Glutamate--cysteine ligase regulatory subunit OS=Bos taurus OX=9913 GN=GCLM PE=3 SV=1 CANONICAL=Q2T9Y6-1" }, "locus": { "chromosome": "3", "start_pos": 49599023, "end_pos": 49582078, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153581.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153581.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105733.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105733.1" } ] } }, { "isoform_ac": "A0ABI0NYJ5-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Y6/entry#A0ABI0NYJ5-1", "sequence": { "sequence": "MIHGATYFFLTRRSQQTIWYILRDCIQKTLNEWSSQISPDLIREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVGSNSSSSTRNAVDMACSVLGVAQLDSVIIASPPVEDGVNLSLEHLQPYWEELQNLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIRAHEWVPLWLLRYSVIVKSRGIIKSKGYILQAKRKGS", "length": 253, "header": "tr|A0ABI0NYJ5-1|A0ABI0NYJ5_BOVIN Computationally mapped isoform of Glutamate--cysteine ligase regulatory subunit OS=Bos taurus OX=9913 GN=GCLM PE=3 SV=1 CANONICAL=Q2T9Y6-1" }, "locus": { "chromosome": "3", "start_pos": 49599023, "end_pos": 49585039, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151311.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151311.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105075.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105075.1" } ] } }, { "isoform_ac": "Q2T9Y6-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Y6/entry#Q2T9Y6-1", "sequence": { "sequence": "MGTDSRAAGALLARASTLHLQTGNLLNWGRLRKKCPSTHSEELRDCIQKTLNEWSSQISPDLIREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVGSNSSSSTRNAVDMACSVLGVAQLDSVIIASPPVEDGVNLSLEHLQPYWEELQNLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIRAHEWVPLWLLRYSVIVKSRGIIKSKGYILQAKRKGS", "length": 274, "header": "sp|Q2T9Y6-1|GSH0_BOVIN Isoform 1 of Glutamate--cysteine ligase regulatory subunit OS=Bos taurus OX=9913 GN=GCLM PE=2 SV=1 CANONICAL=Q2T9Y6-1" }, "locus": { "chromosome": "3", "start_pos": 49599023, "end_pos": 49582078, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026855.5", "url": "https://www.ensembl.org/id/ENSBTAT00000026855.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026855.3", "url": "https://www.ensembl.org/id/ENSBTAP00000026855.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 59, "end_pos": 59, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Y6", "url": "https://www.uniprot.org/uniprotkb/Q2T9Y6" } ], "site_lbl": "Ser59" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:525659", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525659", "resource": "KEGG Pathway" }, { "id": "R-BTA-174403", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174403", "resource": "Reactome", "description": "Glutathione synthesis and recycling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2RBY0-1", "protein_name": "Glutamate--cysteine ligase regulatory subunit", "gene_name": "GCLM", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGTDSRAAGALLARASTLHLQTGNLLNWGRLRKKCPSTHSEEEFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVGSNSSSSTKSAVDMACSVLGVAQLDSVIIASPPVEDGVHLSLEHLQPYWEELQDLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIEAHEWVPLWLLRYSVIVKSRGIIKSKGYILQAKRKSS", "length": 252 }, "evidence": [ { "id": "Q2T9Y6", "url": "https://omabrowser.org/oma/group/Q2T9Y6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O09172-1", "protein_name": "Glutamate--cysteine ligase regulatory subunit", "gene_name": "Gclm", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGTDSRAAGALLARASTLHLQTGNLLNWGRLRKKCPSTHSEELRDCIQKTLNEWSSQISPDLVREFPDVLECTMSHAVEKINPDEREEMKVSAKLFIVGSNSSSSTRSAVDMACSVLGVAQLDSVIMASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIEAQDWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS", "length": 274 }, "evidence": [ { "id": "Q2T9Y6", "url": "https://omabrowser.org/oma/group/Q2T9Y6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P48507-1", "protein_name": "Glutamate--cysteine ligase regulatory subunit", "gene_name": "GCLM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKTLNEWSSQINPDLVREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVAQLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIQAHEWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS", "length": 274 }, "evidence": [ { "id": "Q2T9Y6", "url": "https://omabrowser.org/oma/group/Q2T9Y6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P48508-1", "protein_name": "Glutamate--cysteine ligase regulatory subunit", "gene_name": "Gclm", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGTDSRAAGALLARASTLHLQTGNLLNWGRLRKKCPSTHSEELRDCIQKTLNEWSSQISPDLVREFPDVLECTMSHAVEKINPDEREEMKVSAKLFIVGSNSSSSTRNAVDMACSVLGVAQLDSVIMASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIEAQEWVPLWLLRYSVIVKSRGIIKSKGYILQAKRKGS", "length": 274 }, "evidence": [ { "id": "Q2T9Y6", "url": 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"kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9Z1-1", "uniprot_ac": "Q2T9Z1", "uniprot_id": "DDI1_BOVIN", "mass": { "chemical_mass": 43878.0, "monoisotopic_mass": 43878.0 }, "refseq": { "ac": "NP_001071488", "name": "protein DDI1 homolog 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071488" }, "gene_names": [ { "name": "DDI1", "type": "recommended", "evidence": [ { "id": "Q2T9Z1", "database": 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Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required, with DDI2, for cellular survival following replication stress. 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"end_pos": 4392103, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002887", "url": "https://www.ensembl.org/id/ENSBTAG00000002887" } ] } } ], "crossref": [ { "id": "Q2T9Z1", "url": "https://alphafold.ebi.ac.uk/entry/Q2T9Z1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01796", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01796", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05479", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05479", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539082", "url": "https://www.ncbi.nlm.nih.gov/gene/539082", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033882", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033882", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539082", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539082", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2T9Z1", "url": "https://www.orthodb.org/?gene=Q2T9Z1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15397", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15397", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15397:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15397:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09668", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09668", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24669", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24669", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071488", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2T9Z1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2T9Z1-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLTVYCVRRDLSEATFSLQVRPDFELHNFLVLCELESGIPAEETQIVYMERLLVNDHCSLGSYGLKDGDMVILLQKEAMRPRSPERAAGLCSMEPAGPALPGTSGSRPHQRAQSAQHSSRRGSGEKAGPGQGLDSPALVRSMLLSSPHDLSLLKERNPSLAEALLSGNLESFSQVLMEQQRERALREQERLRLFSADPFDLEAQAKIEEEIRQQNIEENMSIAMEEAPESFGQVAMLYINCRVNGHPLKAFVDSGAQMTIMNQVCAERCNIIRLVDRRWAGVAKGVGTQRILGRVHLAQIQIEGDFLQCSFSILEEQPMDMLLGLDMLRRHQCSIDLKRNVLVIGTTGTQTSFLPEGELPPCAKLVSGMGPEESSDKETANAIKHSVMDSGRKKH", "length": 396, "header": "sp|Q2T9Z1-1|DDI1_BOVIN Isoform 1 of Protein DDI1 homolog 1 OS=Bos taurus OX=9913 GN=DDI1 PE=2 SV=1 CANONICAL=Q2T9Z1-1" }, "isoforms": [ { "isoform_ac": "Q2T9Z1-1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z1/entry#Q2T9Z1-1", "sequence": { "sequence": "MLLTVYCVRRDLSEATFSLQVRPDFELHNFLVLCELESGIPAEETQIVYMERLLVNDHCSLGSYGLKDGDMVILLQKEAMRPRSPERAAGLCSMEPAGPALPGTSGSRPHQRAQSAQHSSRRGSGEKAGPGQGLDSPALVRSMLLSSPHDLSLLKERNPSLAEALLSGNLESFSQVLMEQQRERALREQERLRLFSADPFDLEAQAKIEEEIRQQNIEENMSIAMEEAPESFGQVAMLYINCRVNGHPLKAFVDSGAQMTIMNQVCAERCNIIRLVDRRWAGVAKGVGTQRILGRVHLAQIQIEGDFLQCSFSILEEQPMDMLLGLDMLRRHQCSIDLKRNVLVIGTTGTQTSFLPEGELPPCAKLVSGMGPEESSDKETANAIKHSVMDSGRKKH", "length": 396, "header": "sp|Q2T9Z1-1|DDI1_BOVIN Isoform 1 of Protein DDI1 homolog 1 OS=Bos taurus OX=9913 GN=DDI1 PE=2 SV=1 CANONICAL=Q2T9Z1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:539082", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539082", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Z1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of protein stability", "id": "GO:0031647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Z1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z1" } ], "pmid": "" }, { "name": "proteasomal protein catabolic process", "id": "GO:0010498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010498", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Z1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z1" } ], "pmid": "" }, { "name": "regulation of DNA stability", "id": "GO:0097752", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097752", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Z1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z1" } ], "pmid": "" }, { "name": "cellular response to hydroxyurea", "id": "GO:0072711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072711", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Z1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "aspartic-type endopeptidase activity", "id": "GO:0004190", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004190", "evidence": [ { "database": "UniProtKB", "id": "Q2T9Z1", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 220, "end_pos": 222, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2T9Z1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 396, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2T9Z1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2T9Z1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2T9Z1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z1" }, { "id": "PRU00214", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00214" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubiquitin-like", "eco_id": "ECO_0000255", "start_pos": 1, "end_pos": 81, "start_aa": "Met", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 220, "end_pos": 222 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { 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"o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2T9Z5-1", "uniprot_ac": "Q2T9Z5", "uniprot_id": "TF2H5_BOVIN", "mass": { "chemical_mass": 8053.0, "monoisotopic_mass": 8053.0 }, "refseq": { "ac": "NP_001035627", "name": "general transcription factor IIH subunit 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035627" }, "gene_names": [ { "name": "GTF2H5", "type": "recommended", "evidence": [ { "id": "Q2T9Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z5" } ] }, { "name": "GTF2H5", "type": "synonym", "evidence": [ { "id": "NP_001035627", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035627" } ] } ], "protein_names": [ { "name": "General transcription factor IIH subunit 5", "type": "recommended", "evidence": [ { "id": "Q2T9Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z5/entry#names_and_taxonomy" } ] }, { "name": "General transcription factor IIH polypeptide 5", "type": "synonym", "evidence": [ { "id": "Q2T9Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z5/entry#names_and_taxonomy" } ] }, { "name": "TFB5 ortholog", "type": "synonym", "evidence": [ { "id": "NP_001035627", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035627" }, { "id": "Q2T9Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z5/entry#names_and_taxonomy" } ] }, { "name": "TFIIH basal transcription factor complex TTD-A subunit", "type": "synonym", "evidence": [ { "id": "NP_001035627", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035627" }, { "id": "Q2T9Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z5/entry#names_and_taxonomy" } ] }, { "name": "TFIIH subunit p8", "type": "synonym", "evidence": [ { "id": "NP_001035627", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035627" }, { "id": "Q2T9Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9Z5/entry#names_and_taxonomy" } ] }, { "name": "general transcription factor IIH subunit 5", "type": "synonym", "evidence": [ { "id": "NP_001035627", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035627" } ] }, { "name": "general transcription factor IIH, polypeptide 5", "type": "synonym", "evidence": [ { "id": "NP_001035627", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035627" } ] } ], "function": [ { "annotation": "Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. 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Disrupts the interaction of GLI2 and GLI3 with the negative regulator SUFU. Inhibiting SUFU's interaction with GLI2 promotes the entry of GLI2 into the nucleus, allowing it to activate Hh target gene expression. Disrupting SUFU's interaction with GLI3 prevents its conversion into the repressor form, leading to increased nuclear GLI3 and enhanced Hh signaling. Required for the proper development and structural integrity of photoreceptor outer segment disks, ensuring normal outer segment morphogenesis and survival of photoreceptors.", "evidence": [ { "database": "UniProtKB", "id": "Q2TA01", "url": "https://www.uniprot.org/uniprotkb/Q2TA01#function" }, { "database": "UniProtKB", "id": "Q9CQC4", "url": "https://www.uniprot.org/uniprotkb/Q9CQC4#function" }, { "database": "UniProtKB", "id": "E7EYQ9", "url": "https://www.uniprot.org/uniprotkb/E7EYQ9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TA01", "url": "https://www.uniprot.org/uniprotkb/Q2TA01" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM216", "url": "https://www.uniprot.org/uniprotkb/Q2TA01", "locus": { "chromosome": "29", "start_pos": 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"categories": [ "Protein Classification" ] }, { "id": "Q2TA01", "url": "https://www.orthodb.org/?gene=Q2TA01", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13531", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13531", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13531:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13531:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09799", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09799", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5620912", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001160035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160035", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TA01", "url": 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"sp|Q2TA01-1|TM216_BOVIN Isoform 1 of Transmembrane protein 216 OS=Bos taurus OX=9913 GN=TMEM216 PE=2 SV=2 CANONICAL=Q2TA01-1" }, "locus": {} }, { "isoform_ac": "Q2TA01-2", "url": "https://www.uniprot.org/uniprotkb/Q2TA01/entry#Q2TA01-2", "sequence": { "sequence": "MLFLYLGVEVIRLFFGTKGNLCQRKMPLGISVALTFPSTMMASYYLLLQTYVLRLEAIMNSILLFFCGSELLLEVLTLTAFSSMDRM", "length": 87, "header": "sp|Q2TA01-2|TM216_BOVIN Isoform 2 of Transmembrane protein 216 OS=Bos taurus OX=9913 GN=TMEM216 PE=2 SV=2 CANONICAL=Q2TA01-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "A whole-genome assembly of the domestic cow, Bos taurus.", "journal": "Genome Biol.", "date": "2009", "authors": "Zimin Aleksey V, Delcher Arthur L, Florea Liliana, Kelley David R, Schatz Michael C, Puiu Daniela, Hanrahan Finnian, Pertea Geo, Van Tassell Curtis P, Sonstegard Tad S, Mar\u00e7ais Guillaume, Roberts Michael, Subramanian Poorani, Yorke James A, 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"url": "https://omabrowser.org/oma/group/Q2TA01/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E7EYQ9-1", "protein_name": "Transmembrane protein 216", "gene_name": "tmem216", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MADVCLRLQYACPWQSNMAAHGRQPVLSSTPLQILFHLNGWYFAAFFVAEILMFIYKGVILPYPQDNLILDVVLLLLFSGLETLRLFYGWKGNLCQRSLALFVSVAILVPCAVLSVYYLLLQTFVLRLEFVLNAVLLCFYGFELVLGVMTISIFSRANIY", "length": 160 }, "evidence": [ { "id": "Q2TA01", "url": "https://omabrowser.org/oma/group/Q2TA01/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3IER3-1", "protein_name": "Transmembrane protein 216", "gene_name": "Tmem216", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAPRDKRLSSTPLEVLFFLNGWYYATYFLLELLIFLYKGLLLPYPTANLVLDVVMLLLYLGIEVIRLFFGTKGNLCQRKMPLSISVALTFPSAMMASYYLLLQTYVLRLEAIMNSILLFFCGSELLLEMLTLATFSSMDRI", "length": 141 }, "evidence": [ 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], "protein_names": [ { "name": "BAG family molecular chaperone regulator 5", "type": "recommended", "evidence": [ { "id": "Q2TA08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA08/entry#names_and_taxonomy" } ] }, { "name": "BAG family molecular chaperone regulator 5", "type": "synonym", "evidence": [ { "id": "NP_001035634", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035634" } ] }, { "name": "BAG-5", "type": "synonym", "evidence": [ { "id": "NP_001035634", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035634" }, { "id": "Q2TA08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA08/entry#names_and_taxonomy" } ] }, { "name": "BCL2 associated athanogene 5", "type": "synonym", "evidence": [ { "id": "NP_001035634", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035634" } ] }, { "name": "Bcl-2-associated athanogene 5", "type": "synonym", "evidence": [ { "id": 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"phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TA16-1", "uniprot_ac": "Q2TA16", "uniprot_id": "DRC2_BOVIN", "mass": { "chemical_mass": 58814.0, "monoisotopic_mass": 58814.0 }, "refseq": { "ac": "NP_001033255", "name": "dynein regulatory complex subunit 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033255" }, "gene_names": [ { "name": "DRC2", "type": "recommended", "evidence": [ { "id": "Q2TA16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA16" } ] }, { "name": "CCDC65", "type": "synonym", "evidence": [ { "id": "NP_001033255", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033255" }, { "id": "Q2TA16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA16" } ] }, { "name": "DRC2", "type": "synonym", "evidence": [ { "id": "NP_001033255", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033255" } ] } ], "protein_names": [ { "name": "Dynein regulatory complex subunit 2", "type": "recommended", "evidence": [ { "id": "Q2TA16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA16/entry#names_and_taxonomy" } ] }, { "name": "Coiled-coil domain-containing protein 65", "type": "synonym", "evidence": [ { "id": "Q2TA16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA16/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain-containing protein 65", "type": "synonym", "evidence": [ { "id": "NP_001033255", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033255" } ] }, { "name": "dynein regulatory complex subunit 2", "type": "synonym", "evidence": [ { "id": "NP_001033255", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033255" } ] } ], "function": [ { "annotation": "Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.", "evidence": [ { "database": "UniProtKB", "id": "Q2TA16", "url": "https://www.uniprot.org/uniprotkb/Q2TA16#function" }, { "database": "UniProtKB", "id": "A8JB22", "url": "https://www.uniprot.org/uniprotkb/A8JB22#function" }, { "database": "UniProtKB", "id": "Q8IXS2", "url": "https://www.uniprot.org/uniprotkb/Q8IXS2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TA16", "url": "https://www.uniprot.org/uniprotkb/Q2TA16" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DRC2", "url": "https://www.uniprot.org/uniprotkb/Q2TA16", "locus": {} } ], "crossref": [ { "id": "Q2TA16", "url": "https://alphafold.ebi.ac.uk/entry/Q2TA16", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015825", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015825", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "535207", "url": "https://www.ncbi.nlm.nih.gov/gene/535207", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR039505", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039505", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039750", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039750", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535207", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535207", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WEYLDLF", "url": "https://omabrowser.org/oma/group/WEYLDLF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TA16", "url": "https://www.orthodb.org/?gene=Q2TA16", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21625", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21625", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21625:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21625:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF14772", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14772", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033255", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TA16", "url": "https://www.uniprot.org/uniprotkb/Q2TA16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TA16-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA16-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKKGKKAKVPLSDEEQLLLFQQKLLAEEEMAKKKERLLNQFLKDKLAKEEHNSALNLNKINTQWRTVLREIKTRELHKDIEILSQTFERVVDCKDSVIKSLAKDLSEAEEQHAHALRSHLHSIDQLLALQRCRLNLLEENYNMELEALTKEFETERKTIIDQHEKEIHYLQDVFMAMEQNYIDSEYESKLEFQSMWDDLKNKNLEEKHFLRLQLENIVEDLWRRFQDALKNYTDATEDRKIAFETLKVKDEKSSREIEAQMKKIQKLQDSIIIFKGKILVHSRESEEQNQDIREDKELVLVQLRKLKAQRTQARGIAQENLVKLTLESSATLKALREIVDKGEKILKLAEICRKFETEEEKVLPFYSSVLTPKEQEEIETMDLEEFNEELGKVIMDYKGMENFWKRYNKVKLEQLSLRHRRAQLLEINEKLREMLRQYLDGISVSDEVLSQLNPLFIVNHRSNLPQLLPMPTAQPGDKKPPATYNIIEAAHVVSHTL", "length": 498, "header": "sp|Q2TA16-1|DRC2_BOVIN Isoform 1 of Dynein regulatory complex subunit 2 OS=Bos taurus OX=9913 GN=DRC2 PE=1 SV=1 CANONICAL=Q2TA16-1" }, "isoforms": [ { "isoform_ac": "Q2TA16-1", "url": "https://www.uniprot.org/uniprotkb/Q2TA16/entry#Q2TA16-1", "sequence": { "sequence": "MSKKGKKAKVPLSDEEQLLLFQQKLLAEEEMAKKKERLLNQFLKDKLAKEEHNSALNLNKINTQWRTVLREIKTRELHKDIEILSQTFERVVDCKDSVIKSLAKDLSEAEEQHAHALRSHLHSIDQLLALQRCRLNLLEENYNMELEALTKEFETERKTIIDQHEKEIHYLQDVFMAMEQNYIDSEYESKLEFQSMWDDLKNKNLEEKHFLRLQLENIVEDLWRRFQDALKNYTDATEDRKIAFETLKVKDEKSSREIEAQMKKIQKLQDSIIIFKGKILVHSRESEEQNQDIREDKELVLVQLRKLKAQRTQARGIAQENLVKLTLESSATLKALREIVDKGEKILKLAEICRKFETEEEKVLPFYSSVLTPKEQEEIETMDLEEFNEELGKVIMDYKGMENFWKRYNKVKLEQLSLRHRRAQLLEINEKLREMLRQYLDGISVSDEVLSQLNPLFIVNHRSNLPQLLPMPTAQPGDKKPPATYNIIEAAHVVSHTL", "length": 498, "header": "sp|Q2TA16-1|DRC2_BOVIN Isoform 1 of Dynein regulatory complex subunit 2 OS=Bos taurus OX=9913 GN=DRC2 PE=1 SV=1 CANONICAL=Q2TA16-1" }, "locus": { "chromosome": "5", "start_pos": 30893469, "end_pos": 30885536, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021022.5", "url": "https://www.ensembl.org/id/ENSBTAT00000021022.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021022.3", "url": "https://www.ensembl.org/id/ENSBTAP00000021022.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:535207", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535207", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZIS3-1", "protein_name": "Dynein regulatory complex subunit 2", "gene_name": "CCDC65", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPVKRQQRAAAPTSAEDGLLLLQGQALAEEEAAKRKREMLSRFLKDKLSQEQQSTALNLHKLHSQWRAVLREAKAQELQQDVAILSQTFARVMDSKDSVIESLVTDLEEAEVQHSRALSGHLQNVDRLLQLQRCRLRCMEEGYRAQLEELQEEFETERRSIVERHQRELRYLQDVAVAVEQNHAREEHEATLNFQSTRDEIKNKSLQEKQYTRLQLSGKLEGLWEQFHCAMQSYAEATERRKLSFEALKAKDEKSSREVEVQEKKLQKLQDAVLAAKARLAAHLRAGEEQNGRVREQKEAALGQLQQLKSEMSRARAKAHRSLAELTAQSGAALKALGKIVGKAERVLRLAELCRRMESEEEKVLPFYPSSLAEGERDDAERVLREAPTEPLARAVLDYVGLEGFWRRFNKAKLEEVAAGQQRAALTHSNRRLRALLRRYLDGLAANADALSEANALPDVSNGSRVPKACLQRSRDAPQPHDPPARRGAVGHAVGLRAEPQSREGP", "length": 506 }, "evidence": [ { "id": "Q2TA16", "url": "https://omabrowser.org/oma/group/Q2TA16/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SPN2-1", "protein_name": "Dynein regulatory complex subunit 2", "gene_name": "CCDC65", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSKKGKKAKIPLSDEEQLLLFQQKLLAEEEMAKKKERLLNQFLKDKLAKEEHNSAMNLNKINTQWRTVLREVKTRELHKDIEILSQTFERVVDCKDSVIKSLAKDLSEAEEQYAHALRSHLHNIDQLLALQRCRLSLLEENYNMELESLTKEFETERKTIVDQHEKEIRYLQDVFMAMEQNYIDSEYESKLEFQSMWDDLKNKNLEEKHFLRLQLENAVEDLWRRFQDALKNYTDATEDRKIAFETLKVKDERSSKEIEAQMKKIQRLQDSIIILKGKIMVHSRESEEQNQDIRDDKELVLVQLQKLKAQRTQARGVSQENLVRLTLESNATLKALRRTVDKGEKILKLAEICRKFETEEEKVLPFYSSVLTPEEQEEIEKTDPEEFNEELAKAIVDYTGMENFWKRYNKVKLEQLSLQHRRTQLLKINEKLREMLRQYLDGISVSDEVLSQLNPLFIVNHRSNLPRPLSTPTAEPGDKKPPTTYNIIEAAHVISHIL", "length": 498 }, "evidence": [ { "id": "Q2TA16", "url": "https://omabrowser.org/oma/group/Q2TA16/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5XIJ8-1", "protein_name": "Dynein regulatory complex subunit 2", "gene_name": "Drc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKKGKKPKLPLTDEEQLILFQQKLLADEEAAKKKERLLTQFLKDKLAKEEHNSSLNLNKINTQWRTVLREVKTRELHKDIEILSQIFERVVDCKDSVIKSLARDLTEAEEQYAHALRGHLHNVDQLLTLQRRRLSLLEENYNMELEVLTKEFETERKAILDHHDKEIHYLHDVFMAMEQNYVDSEYESKLEFQSMWDDLKNKNLEEKHFLRLQLENVVEDLWRRFQDALKNYTDATEDRKIAFETLKVKDEKSSKEIEVQMKKIQRLQEAISALKGKIVAHSREGEWQNQCIRNDKELVHVQLRKLKIQRTQARTESQENLVKLTLESNATLKALKKVVEKGEKILKLAEICRKFETEEEKVLPFYSSALTPEEQEEVEIQSQEEITEDLAKIMMDYLGMENFWKRYNKVKLEVLSLQHRRLQLLDISSKLREMLKQYLDGISVSDEVLSRLNPLFIVNHKSNLPQLPPSAAQPGGDRGPGGDRRLTYNVIEAAHIASHIL", "length": 502 }, "evidence": [ { "id": "Q2TA16", "url": "https://omabrowser.org/oma/group/Q2TA16/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6DHI2-1", "protein_name": "Dynein regulatory complex subunit 2", "gene_name": "drc2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPKKAGKKAGGKLAGLTEEERLLYMQQKAQAEEEIAKRKEDMLTHFLKDKLQKEEKNTVLNLHKLRQQWRAVLTQTKIAELRNDMSVLSQTFERVLDYKDNIIRSLQVDLSERELQSELKRSSHLHNVDCLLEIHKSRLAQLEFNFKSSLVELSSEYNTEREQILSQHQQECVDLDNVMFSMEKHYSDLDGEAKRDYQSTRNQIKKRNFDDKQAVKEQMDGVVEKLWQDQQQVLNHYNESTRDKIITTDDLMNKDVQSAKEIDSLKKHIQKLQDSISTFRGQLSSGQTDKTAEQLRSERDELAQEVQHFRVQLNAAQAIRKKHITKLTVQSNDATKKLQEIVARGERLLRQCEMCCKLETEHEKVLPFYKSSLSEEEQKQEKAKAMESSNEKLTQLMHDYSPLAKFWQRYNKVELDCLCVKREKLLLLQENERLRLFLKQYLDEVSVSDESFRQQKLLVVSSPALQDTAATDRHQQKRHVVQEAACIVQKQL", "length": 492 }, "evidence": [ { "id": "Q2TA16", "url": "https://omabrowser.org/oma/group/Q2TA16/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8IXS2-1", "protein_name": "Dynein regulatory complex subunit 2", "gene_name": "DRC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPKKEKMAKTPLSDEKQLLLFQQKLLAEEEMAKKKERLLSQFLKDKLAKEEHNSALNLNKINTQWRTVLREVKTRELHKDIEILSQTFERVVDCKDNVIKSLAKDLSEAEEQYAHALRSHLHNVDQLLALQRHRLSLLEESYNMELEALTKEFETERKTIIDQHEKEIHYLQDIFMAMEQNYIDSEYESKLEFQSMWNDLKNMNLEEKHFLRLHLENRVEDLWRKFQDVLKNYTDATEDRKAAFETLQVKDEKSSKEIEVQMKKIQKLQDAITISKGKIMIHSRESEDENRYIRNDKELVLVQLRKLKAQRTQARAASQKNLVRLTLESNATLKALRKIVDKGEKILKLAEICRKFETEEEKVLPFYSSVLTPKEQEGIQKNNLEELTEELTKVMVDYIGMENFWKRYNKVKLEQLSLQHRRAQLLDINGKLREMLKQYLDGISVSDEVLSQLNPLFIVNYQSNLLQPLSIRIAHPGDKQHPTT", "length": 484 }, "evidence": [ { "id": "Q2TA16", "url": "https://omabrowser.org/oma/group/Q2TA16/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VHI7-1", "protein_name": "Dynein regulatory complex subunit 2", "gene_name": "Drc2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSKKGKKPKLPKAPLSEEDQLLIFQQKMLADEEAAKKKERLLTQFLKDKLAKEEHNSALNLNKINTQWRTILREVKTRELHQDIEILSQTFERVVDCKDSVIKSLAKDLTEAEEQYAHALRSHLHNIDQLLTLQRRRLGLLEENYNMELEVLTKEFETERKLIIDHHEKEMHYLQDVFMAMEQNYIDSEYESKLEFQSMWDDLKNKNLEEKHFLRLQLENIVEDLWRRFQDALKNYTDATEDRKIAFEYLKVKDEKSSKEIETQMKKIQKLQETIGILKGKIVAHSREGEWQNQCIRNNKELVHVQLRKLKVQRTQARTLSQENLVKLTLESNATLKALKKVVEKGEKILKLAEICRKFETEEEKVLPFYSSVLTPEEQEEAKLQNPEDITEDLAKIMMDYAGMENFWKRYNKVKLEVLSLQHRRLQLLDISSKLREMLKQYLDGISVSDEVLSHLNPLFVVNHRSNLPQLPPPSAQPVYNVIEAAHIASHIL", "length": 493 }, "evidence": [ { "id": "Q2TA16", "url": "https://omabrowser.org/oma/group/Q2TA16/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9W212-1", "protein_name": "Dynein regulatory complex subunit 2", "gene_name": "CG13522", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGKKGKGKGNKLANMSEEERARYLQMRADMEEETRRRKMQLISMYMKNKLKREDAFGRLNMAKINQEWRSILRQVKIQELRREIVDVESFFQEALKRKDQVIHRLIAHIESTEDMYANLQQSHMENITRIVDTHRDRIEFFRTIYEDDKQAVLSQWEQDSAAFKEMHAQKQQQLECVFYQLEENTDGGIRDNHERFLDRCEDLKSGMQLQLEQITSRGEARLEKLWQEYQGVLAGYCQHIEGFYSEYVDLKQRDEEAALQISQQTHEIEHLVDQLTNLRLVSEEFYIKQQGQLEQRQAIKQQLTERLRELRTCVEQEVARDHQLFKLMSVESYHALEFLQETVAKGETLAQLSAVCAKMETQRERMFQLPEISKEIIEIRDIEDQGNGSLTDPATDLLKDEVAVVPQMESFWRRVNNVAVDVACLKQQKRRLEAENSQLKTQLQDYLVNLNIANGSNSHVHSYLARRPKSMSVDRVSRLQLQPKLVKSAQPTGRRPAAPTPPTFHLHPGRSRAPAFEANLSNVVLSRTLARGKMNLARME", "length": 540 }, "evidence": [ { "id": "Q2TA16", "url": "https://omabrowser.org/oma/group/Q2TA16/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "Q2TA16", "url": "https://www.uniprot.org/uniprotkb/Q2TA16" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "Q2TA16", "url": "https://www.uniprot.org/uniprotkb/Q2TA16" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "Q2TA16", "url": "https://www.uniprot.org/uniprotkb/Q2TA16" } ], "pmid": "" }, { "name": "axonemal dynein complex", "id": "GO:0005858", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005858", "evidence": [ { "database": "UniProtKB", "id": "Q2TA16", "url": "https://www.uniprot.org/uniprotkb/Q2TA16" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cilium-dependent cell motility", "id": "GO:0060285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060285", "evidence": [ { "database": "UniProtKB", "id": "Q2TA16", "url": "https://www.uniprot.org/uniprotkb/Q2TA16" } ], "pmid": "" }, { "name": "axonemal dynein complex assembly", "id": "GO:0070286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070286", "evidence": [ { "database": "UniProtKB", "id": "Q2TA16", "url": "https://www.uniprot.org/uniprotkb/Q2TA16" } ], "pmid": "" }, { "name": "regulation of cilium movement", "id": "GO:0003352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003352", "evidence": [ { "database": "UniProtKB", "id": "Q2TA16", "url": "https://www.uniprot.org/uniprotkb/Q2TA16" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 232, "end_pos": 234, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TA16-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 498, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": 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"MSLLRITSSAHSSASSRLWRLGIFLLLSLPDSKGKAIWTAHLNITFQVGSRLISELGESGVFGNHSPLERVSGVVVLPEGWNQNACNPMTNFSRPGQTDPWLALIERGGCTFTRKINVAAEKGANGVIIYNYPGTGNKVFPMSHQGTENIVAVMIGNLKGMELLHLIQKGVYVKIIIEVGRMHMPWLSHYIMSLFTFLTATVAYLFLYCAWRPRGPNFSTRRQRQLKADVRKAIGKLQLRVLQEGDKELEPDEDNCVVCFDIYKPQDVVRILTCKHIFHKACIDPWLLAHRTCPMCKCDILQT", "length": 303, "header": "sp|Q2TA44-1|RN148_BOVIN Isoform 1 of RING finger protein 148 OS=Bos taurus OX=9913 GN=RNF148 PE=2 SV=1 CANONICAL=Q2TA44-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 43, "start_aa": "Asn", "end_pos": 43, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn43", "evidence": [ { "id": "Q2TA44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA44#ptm_processing" } ] } ], 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"https://www.uniprot.org/uniprotkb/Q2TA44" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "Q2TA44", "url": "https://www.uniprot.org/uniprotkb/Q2TA44" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" }, { "start_pos": 64, "end_pos": 66, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TA44-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 303, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TA44-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TA44" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 43 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 217, "end_pos": 219 }, { "start_pos": 43, "end_pos": 45 }, { "start_pos": 64, "end_pos": 66 }, { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBI0-1", "uniprot_ac": "Q2TBI0", "uniprot_id": "LBP_BOVIN", "mass": { "chemical_mass": 53698.0, "monoisotopic_mass": 53698.0 }, "refseq": { "ac": "NP_001033763", "name": "lipopolysaccharide-binding protein precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033763" }, "gene_names": [ { "name": "LBP", "type": "recommended", "evidence": [ { "id": "Q2TBI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI0" } ] }, { "name": "LBP", "type": "synonym", "evidence": [ { "id": "NP_001033763", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033763" } ] } ], "protein_names": [ { "name": "Lipopolysaccharide-binding protein", "type": "recommended", "evidence": [ { "id": "Q2TBI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI0/entry#names_and_taxonomy" } ] }, { "name": "LBP", "type": "synonym", "evidence": [ { "id": "Q2TBI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI0/entry#names_and_taxonomy" } ] }, { "name": "lipopolysaccharide-binding protein precursor", "type": "synonym", "evidence": [ { "id": "NP_001033763", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033763" } ] } ], "function": [ { "annotation": "One possible anti-inflammatory mechanism can be attributed to the negative role of BRLBP in suppressing TLR4/NF-kappaB activation mediated by LPS. These findings suggested that BRLBP may be a useful agent to treat LPS-induced mastitis", "evidence": [ { "database": "RefSeq", "id": "NP_001033763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033763" }, { "database": "PubMed", "id": "25700343", "url": "https://glygen.org/publication/PubMed/25700343" } ] }, { "annotation": "Our study provides an overview of the gene expression profile between wild LBP and mutant LBP on the LPS-induced inflammatory response of bovine mammary epithelial cells , which will lead to further understanding of the potential effects of LBP mutations on bovine mammary glands.", "evidence": [ { "database": "RefSeq", "id": "NP_001033763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033763" }, { "database": "PubMed", "id": "26813383", "url": "https://glygen.org/publication/PubMed/26813383" } ] }, { "annotation": "Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI0", "url": "https://www.uniprot.org/uniprotkb/Q2TBI0#function" }, { "database": "UniProtKB", "id": "P18428", "url": "https://www.uniprot.org/uniprotkb/P18428#function" } ] }, { "annotation": "Single nucleotide polymorphisms in the lipopolysaccharide-binding protein may hold the secret of susceptibility to clinical mastitis in Chinese Holstein.", "evidence": [ { "database": "RefSeq", "id": "NP_001033763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033763" }, { "database": "PubMed", "id": "22733492", "url": "https://glygen.org/publication/PubMed/22733492" } ] }, { "annotation": "The presence of lipopolysaccharide binding protein (LBP) and alpha1-acid glycoprotein (AGP) was demonstrated in all seven adipose tissue depots. Expression of AGP and LBP suggests that they may have roles as local and systemic inflammatory adipokines.", "evidence": [ { "database": "RefSeq", "id": "NP_001033763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033763" }, { "database": "PubMed", "id": "25542063", "url": "https://glygen.org/publication/PubMed/25542063" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBI0", "url": "https://www.uniprot.org/uniprotkb/Q2TBI0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LBP", "url": "https://www.uniprot.org/uniprotkb/Q2TBI0", "locus": { "chromosome": "13", "start_pos": 67247271, "end_pos": 67214618, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016864", "url": "https://www.ensembl.org/id/ENSBTAG00000016864" } ] } } ], 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"http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10504:SF66", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01273", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01273", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02886", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02886", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033763", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBI0", "url": "https://www.uniprot.org/uniprotkb/Q2TBI0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBI0-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVTSTGTLPSLLLGTLLTFTSGALGANPGLVVRITDQGLEYVAQEELLALQSKLHKVTLPDFNGDVRIKHFGSVDYRFHSLNIQSCKLLGSALKLLPNQGLHFSISDSFIQVTGDWKVRKRILRLDGSFDVKVKGITISVNLLLDSEPSGRPKVAVSSCSSHIRDVEVHISGDLGWLLNLFHNQIESRFRRVLESKICEIIEDSVTSELQPYLQTLPVTTEIDHLAGLDYSLMGAPQATAQMLDVMFKGEIFSRDDRFPVAFLAPVMNLPEEHSRMVYFAISDYAFNTASLVYHKAGFLNFTITDDVIPPDSSIRQNTKSFRAFVPRIARLYPNTNLELQGAVISAPCLNFSPGNLSTAAQMEIEAFVLLPNSVKEPVFRLSVATNVSAMLTFNTSKITGFLEPGKIQVELKESKVGRFNVELLEALLNYYLLNNFYPKVNDKLAEGFPLPLLRKIQLYDPILQIHKDFLFLGTNVRYLRV", "length": 481, "header": "sp|Q2TBI0-1|LBP_BOVIN Isoform 1 of Lipopolysaccharide-binding protein OS=Bos taurus OX=9913 GN=LBP PE=2 SV=1 CANONICAL=Q2TBI0-1" }, "isoforms": [ { "isoform_ac": "Q2TBI0-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI0/entry#Q2TBI0-1", "sequence": { "sequence": "MVTSTGTLPSLLLGTLLTFTSGALGANPGLVVRITDQGLEYVAQEELLALQSKLHKVTLPDFNGDVRIKHFGSVDYRFHSLNIQSCKLLGSALKLLPNQGLHFSISDSFIQVTGDWKVRKRILRLDGSFDVKVKGITISVNLLLDSEPSGRPKVAVSSCSSHIRDVEVHISGDLGWLLNLFHNQIESRFRRVLESKICEIIEDSVTSELQPYLQTLPVTTEIDHLAGLDYSLMGAPQATAQMLDVMFKGEIFSRDDRFPVAFLAPVMNLPEEHSRMVYFAISDYAFNTASLVYHKAGFLNFTITDDVIPPDSSIRQNTKSFRAFVPRIARLYPNTNLELQGAVISAPCLNFSPGNLSTAAQMEIEAFVLLPNSVKEPVFRLSVATNVSAMLTFNTSKITGFLEPGKIQVELKESKVGRFNVELLEALLNYYLLNNFYPKVNDKLAEGFPLPLLRKIQLYDPILQIHKDFLFLGTNVRYLRV", "length": 481, "header": "sp|Q2TBI0-1|LBP_BOVIN Isoform 1 of Lipopolysaccharide-binding protein OS=Bos taurus OX=9913 GN=LBP PE=2 SV=1 CANONICAL=Q2TBI0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 300, "start_aa": "Asn", "end_pos": 300, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn300", "evidence": [ { "id": "Q2TBI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI0#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 355, "start_aa": "Asn", "end_pos": 355, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn355", "evidence": [ { "id": "Q2TBI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI0#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 386, "start_aa": "Asn", "end_pos": 386, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn386", "evidence": [ { "id": "Q2TBI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI0#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 394, "start_aa": "Asn", "end_pos": 394, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn394", "evidence": [ { "id": "Q2TBI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI0#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Mutations in lipopolysaccharide-binding protein (LBP) gene change the susceptibility to clinical mastitis in Chinese Holstein.", "journal": "Molecular biology reports", "date": "2012-10", "authors": "Cheng Jienan, Li Jun, Zhang Wenxin, Cai Yafei, Wang Genlin", "evidence": [ { "database": "RefSeq", "id": "NP_001033763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033763" } ], "reference": [ { "type": "PubMed", "id": "22733492", "url": "https://glygen.org/publication/PubMed/22733492" } ] }, { "title": "Expression of \u03b11-acid glycoprotein and lipopolysaccharide binding protein in visceral and subcutaneous adipose tissue of dairy cattle.", "journal": "Veterinary journal (London, England : 1997)", "date": "2015-02", "authors": "Rahman Mizanur M, Lecchi Cristina, Sauerwein Helga, Mielenz Manfred, H\u00e4u\u00dfler Susanne, Restelli Laura, Giudice Chiara, Ceciliani Fabrizio", "evidence": [ { "database": "RefSeq", "id": "NP_001033763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033763" } ], "reference": [ { "type": "PubMed", "id": "25542063", "url": "https://glygen.org/publication/PubMed/25542063" } ] }, { "title": "Bovine recombinant lipopolysaccharide binding protein (BRLBP) regulated apoptosis and inflammation response in lipopolysaccharide-challenged bovine mammary epithelial cells (BMEC).", "journal": "Molecular immunology", "date": "2015-06", "authors": "Sun Yu, Li Lian, Wu Jie, Yu Pan, Li Chengmin, Tang Juan, Li Xiaojuan, Huang Shuai, Wang Genlin", "evidence": [ { "database": "RefSeq", "id": "NP_001033763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033763" } ], "reference": [ { "type": "PubMed", "id": "25700343", "url": "https://glygen.org/publication/PubMed/25700343" } ] }, { "title": "Comparison of the effect of recombinant bovine wild and mutant lipopolysaccharide-binding protein in lipopolysaccharide-challenged bovine mammary epithelial cells.", "journal": "Cell stress & chaperones", "date": "2016-05", "authors": "Li Xiaojuan, Li Lian, Sun Yu, Wu Jie, Wang Genlin", "evidence": [ { "database": "RefSeq", "id": "NP_001033763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033763" } ], "reference": [ { "type": "PubMed", "id": "26813383", "url": "https://glygen.org/publication/PubMed/26813383" } ] } ], "pathway": [ { "id": "bta:512242", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512242", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "positive regulation of macrophage activation", "id": "GO:0043032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043032", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI0", "url": "https://www.uniprot.org/uniprotkb/Q2TBI0" } ], "pmid": "" }, { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI0", "url": "https://www.uniprot.org/uniprotkb/Q2TBI0" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { 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"extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI0", "url": "https://www.uniprot.org/uniprotkb/Q2TBI0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lipopolysaccharide binding", "id": "GO:0001530", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001530", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI0", "url": "https://www.uniprot.org/uniprotkb/Q2TBI0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 300, "end_pos": 302, "annotation": "n_glycosylation_sequon" }, { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 355, "end_pos": 357, "annotation": "n_glycosylation_sequon" }, { "start_pos": 386, "end_pos": 388, "annotation": "n_glycosylation_sequon" }, { "start_pos": 394, "end_pos": 396, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], 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"https://omabrowser.org/oma/group/FMGINRT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBI1", "url": "https://www.orthodb.org/?gene=Q2TBI1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16140", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16140", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16140:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16140:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08743", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08743", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3108214", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3108214", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001033767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033767", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBI1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBI1-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGDSSGRRPEGRGRGRDPHRDRTRSRSRSRSPLSPGSRRGAAPERREAPERPGLEDTEPSDSGDEMIDPASLEEETDPSLCRQIRHQYRALINSVQQNREDILNASDKLTEVLEEANTLFNGVSRAREAVLDAHFLVLASDLGKEKAKQLRSDLNSFDMLRYVETLLTHMGVNPLEAEELIRDEDSSDLEFIVYDSWKISGKTAENTFNKTHTFHFLLGSIQGECPVPKPRIERPRKVRMIEEQQAMPAQLKRMEESHQEATEKEVERILGLLQTYFQEDPDTPMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDRDRLPVIEPVNINEESGGNTQIRNQAIIALSYRDWEEIVRTFEISEPVITSSQSQQRLSA", "length": 382, "header": "sp|Q2TBI1-1|NSE4A_BOVIN Isoform 1 of Non-structural maintenance of chromosomes element 4 homolog A OS=Bos taurus OX=9913 GN=NSMCE4A PE=2 SV=1 CANONICAL=Q2TBI1-1" }, "isoforms": [ { "isoform_ac": "Q2TBI1-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI1/entry#Q2TBI1-1", "sequence": { "sequence": "MSGDSSGRRPEGRGRGRDPHRDRTRSRSRSRSPLSPGSRRGAAPERREAPERPGLEDTEPSDSGDEMIDPASLEEETDPSLCRQIRHQYRALINSVQQNREDILNASDKLTEVLEEANTLFNGVSRAREAVLDAHFLVLASDLGKEKAKQLRSDLNSFDMLRYVETLLTHMGVNPLEAEELIRDEDSSDLEFIVYDSWKISGKTAENTFNKTHTFHFLLGSIQGECPVPKPRIERPRKVRMIEEQQAMPAQLKRMEESHQEATEKEVERILGLLQTYFQEDPDTPMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDRDRLPVIEPVNINEESGGNTQIRNQAIIALSYRDWEEIVRTFEISEPVITSSQSQQRLSA", "length": 382, "header": "sp|Q2TBI1-1|NSE4A_BOVIN Isoform 1 of Non-structural maintenance of chromosomes element 4 homolog A OS=Bos taurus OX=9913 GN=NSMCE4A PE=2 SV=1 CANONICAL=Q2TBI1-1" }, "locus": { "chromosome": "26", "start_pos": 41855397, "end_pos": 41842708, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025508.4", "url": "https://www.ensembl.org/id/ENSBTAT00000025508.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025508.2", "url": "https://www.ensembl.org/id/ENSBTAP00000025508.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 342, "end_pos": 342, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI1" } ], "site_lbl": "Thr342" }, { "start_pos": 374, "end_pos": 374, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI1" } ], "site_lbl": "Ser374" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:527312", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527312", "resource": "KEGG Pathway" }, { "id": "R-BTA-3108214", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3108214", "resource": "Reactome", "description": "SUMOylation of DNA damage response and repair proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2N369-1", "protein_name": "Non-structural maintenance of chromosomes element 4", "gene_name": "Nsmce4a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSGDSSGRRPEGRGRGHDPHRDRTRSRSRSRSPLARRGAAPERREAAERPSLEDSEPSDSGDELMDPACLEAEYDQGLCRQIRHQYRALINSVQQNREDILNAGDKLTEVLEEANTLFNEVSRAREAVLDAQFLVLASDLGKEKAKQLRSDLSSFDMLRYVETLLTHMGVNPLEAEEFIRDEDRNDIELIVYDSWKISGKTAENTFNKTHTFHFLLGSIHGEFPVPKPRTDRPRQPRMIEEQRAMPAQLKCMEESHQEATEKEVERILGLLQTYFREDPDTPMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPVIEPVINEESDGIEQNTQIRSQGIIALSYRDWEEIVKTFEISEPVISMSQSQQRLSA", "length": 381 }, "evidence": [ { "id": "Q2TBI1", "url": "https://omabrowser.org/oma/group/Q2TBI1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3Z9K8-1", "protein_name": "Non-structural maintenance of chromosomes element 4", "gene_name": "Nsmce4a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGDSSGRRSEGRGRGRDPHRDRTRSRSRSRSPLARRGAAPERREAAERPSLEDTEPSDSGDELMDPACLEAEYDQGLCRQIRHQYRALINSVQQNREDILNAGDKLTEVLEEANTLFNEVSRAREAVLDAQFLVLASDLGKEKAKQLRSDLSSFDMLRYVETLLTHMGVNPLEAEEFIRDEDRTDIELIVYDSWKISGKTAENTFNKTHTFHFLLGSIHGEFPVPKPRTDRPRQPRMIEEQRAMPAQLKCMEESHQEATEKEVERILGLLQTYFREDPDTPMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPIIEPVINEESEGIDQNIQFRSQGIIALSYHDWEEIVKTFEISEPVISLSQSQQRLSA", "length": 381 }, "evidence": [ { "id": "Q2TBI1", "url": "https://omabrowser.org/oma/group/Q2TBI1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3XA30-1", "protein_name": "Non-structural maintenance of chromosomes element 4", "gene_name": "Nsmce4a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGDSSGRRSEGRGRGRDPHRDRTRSRSRSRSPLARRGAAPERREAAERPSLEDSDLSDSGDELMDPACLEAEYDQGLCRQIRHQYRALINSVQQNREDILNAGDKLTEVLEEANTLFNEVSRAREAVLDAQFLVLASDLGKEKAKQLRSDLSSFDMLRYVETLLTHMGVNPLEAQEVIRDEDRADIELIVYDSWKISGKTAENTFNKTHTFHFLLGSIHGEFPVPKPRSDRPRQPRMIEEQRAMPAQLKCMEESHQEATEKEVERILGLLQTYFREDPDTPMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPIIEPVINEESEGIDHNIQIRSQGIIALSYHDWEEIVKTFEISEPVIPLSQSQQRLSA", "length": 381 }, "evidence": [ { "id": "Q2TBI1", "url": "https://omabrowser.org/oma/group/Q2TBI1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54T56-1", "protein_name": "Non-structural maintenance of chromosomes element 4", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNRNNSNGVGSSTGAGSSQSGIDNNNNNNNNSNNNNNRQQDESPNSKKVVKKQQQTIGERRELRKKYRTLIQDVSGNKSELILPSSDGLLRSLKKADNLYNNVLQAREAVLDSELLALASQFGVEQAQKFKVSLNGFDSFGLVNRYKERLTFYTDENNNNNSTINKTGWEKLSQLYHTHFHTVPDFDFMYGPINFEPEEKKVRAPRKLTQKDQPVGAAKHAEKITDTSNQVESETTSSRVQVMKQYIEKNPGKSFIDLVVDETSFAQTVENIFYFSFLLKDGHVKIAKDNEEMIIQTTLPPEEKDYQSKNAQLTHSVVKLDFNTWNDLKDISDLSFHMEEELQQFKNRRGGGGGGGSSTQTHTSTRK", "length": 367 }, "evidence": [ { "id": "Q2TBI1", "url": "https://omabrowser.org/oma/group/Q2TBI1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9NXX6-1", "protein_name": "Non-structural maintenance of chromosomes element 4 homolog A", "gene_name": "NSMCE4A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGDSSGRGPEGRGRGRDPHRDRTRSRSRSRSPLSPRSRRGSARERREAPERPSLEDTEPSDSGDEMMDPASLEAEADQGLCRQIRHQYRALINSVQQNREDILNAGDKLTEVLEEANTLFNEVSRAREAVLDAHFLVLASDLGKEKAKQLRSDLSSFDMLRYVETLLTHMGVNPLEAEELIRDEDSPDFEFIVYDSWKITGRTAENTFNKTHTFHFLLGSIYGECPVPKPRVDRPRKVPVIQEERAMPAQLRRMEESHQEATEKEVERILGLLQTYFREDPDTPMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPVIEPVSINEENEGFEHNTQVRNQGIIALSYRDWEEIVKTFEISEPVITPSQRQQKPSA", "length": 385 }, "evidence": [ { "id": "Q2TBI1", "url": "https://omabrowser.org/oma/group/Q2TBI1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI1" } ], "pmid": "" }, { "name": "chromosome, telomeric region", "id": "GO:0000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI1" } ], "pmid": "" }, { "name": "Smc5-Smc6 complex", "id": "GO:0030915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030915", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI1" } ], "pmid": "" }, { "name": "DNA recombination", "id": "GO:0006310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006310", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI1" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "Q2TBI1", "url": "https://www.uniprot.org/uniprotkb/Q2TBI1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 105, "end_pos": 107, "annotation": "n_glycosylation_sequon" }, { "start_pos": 210, "end_pos": 212, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBI1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 382, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBI1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBI1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 342, 374 ], "sequon_annotation_sites": [ { "start_pos": 105, "end_pos": 107 }, { "start_pos": 210, "end_pos": 212 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBI5-1", "uniprot_ac": "Q2TBI5", "uniprot_id": "CANB2_BOVIN", "mass": { "chemical_mass": 19548.0, "monoisotopic_mass": 19548.0 }, "refseq": { "ac": "NP_001073099", "name": "calcineurin subunit B type 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073099" }, "gene_names": [ { "name": "PPP3R2", "type": "recommended", "evidence": [ { "id": "Q2TBI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI5" } ] }, { "name": "PPP3R2", "type": "synonym", "evidence": [ { "id": "NP_001073099", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073099" } ] } ], "protein_names": [ { "name": "Calcineurin subunit B type 2", "type": "recommended", "evidence": [ { "id": "Q2TBI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI5/entry#names_and_taxonomy" } ] }, { "name": "Protein phosphatase 2B regulatory subunit 2", "type": "synonym", "evidence": [ { "id": "Q2TBI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI5/entry#names_and_taxonomy" } ] }, { "name": "Protein phosphatase 3 regulatory subunit B beta isoform", "type": "synonym", "evidence": [ { "id": "Q2TBI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBI5/entry#names_and_taxonomy" } ] }, { "name": "calcineurin B, type II", "type": "synonym", "evidence": [ { "id": "NP_001073099", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073099" } ] }, { "name": "calcineurin subunit B type 2", "type": "synonym", "evidence": [ { "id": "NP_001073099", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073099" } ] }, { "name": "protein phosphatase 2B regulatory subunit 2", "type": "synonym", "evidence": [ { "id": "NP_001073099", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073099" } ] } ], "function": [ { "annotation": "Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. 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"o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBK7-1", "uniprot_ac": "Q2TBK7", "uniprot_id": "RUSD3_BOVIN", "mass": { "chemical_mass": 37008.0, "monoisotopic_mass": 37008.0 }, "refseq": { "ac": "NP_001033650", "name": "mitochondrial mRNA pseudouridine synthase RPUSD3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033650" }, "gene_names": [ { "name": "RPUSD3", "type": "recommended", "evidence": [ { "id": "Q2TBK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBK7" } ] }, { "name": "RPUSD3", "type": "synonym", "evidence": [ { "id": "NP_001033650", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033650" } ] } ], "protein_names": [ { "name": "Mitochondrial mRNA pseudouridine synthase RPUSD3", "type": "recommended", "evidence": [ { "id": "Q2TBK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBK7/entry#names_and_taxonomy" } ] }, { "name": "5.4.99.-", "type": "synonym", "evidence": [ { "id": "Q2TBK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBK7/entry#names_and_taxonomy" } ] }, { "name": "RNA pseudouridylate synthase domain containing 3", "type": "synonym", "evidence": [ { "id": "NP_001033650", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033650" } ] }, { "name": "RNA pseudouridylate synthase domain-containing protein 3", "type": "synonym", "evidence": [ { "id": "NP_001033650", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033650" }, { "id": "Q2TBK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBK7/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial mRNA pseudouridine synthase RPUSD3", "type": "synonym", "evidence": [ { "id": "NP_001033650", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033650" } ] } ], "function": [ { "annotation": "Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post-transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK7", "url": "https://www.uniprot.org/uniprotkb/Q2TBK7#function" }, { "database": "UniProtKB", "id": "Q6P087", "url": "https://www.uniprot.org/uniprotkb/Q6P087#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBK7", "url": "https://www.uniprot.org/uniprotkb/Q2TBK7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPUSD3", "url": "https://www.uniprot.org/uniprotkb/Q2TBK7", "locus": { "chromosome": "22", "start_pos": 16886849, "end_pos": 16878548, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007968", "url": "https://www.ensembl.org/id/ENSBTAG00000007968" } ] } } ], "crossref": [ { "id": "Q2TBK7", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBK7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02869", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02869", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534606", "url": "https://www.ncbi.nlm.nih.gov/gene/534606", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534606", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534606", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBK7", "url": "https://www.orthodb.org/?gene=Q2TBK7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21600", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21600", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21600:SF49", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21600:SF49", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00849", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00849", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033650", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "56644", "url": "https://www.rhea-db.org/rhea/56644", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBK7", "url": "https://www.uniprot.org/uniprotkb/Q2TBK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBK7-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBK7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGWRVLGQASGGWRRGLGIRATSTAAGFGTKARHQLQRRGASKPSDPPGDQPFPGLLRPGTFSREELVDVLRAAVVDSKGPLVTLNKPQGLPVTGKPGELTLLSVLPELSRSLGLGEQEVQVVRASGKEASGLVLLSSCSQTASRLQKFFTHSRRARKPTATYCAVTDGIPVTSEGKIQAALKLEHIDGVNLVVPVQSPSRKDIMEGVKRTLSHFRVVATGSGCALVQLQPLTVFPSQLQAHMALQLCPVLGDHTYSARVGTVLGQRFLLPVESTKPQRQVLDEALLGRLCLTASQAARLPLHLHLHCLRLPGARPRDPPIELLAPLPSYFSRTLQCLGLHYQ", "length": 344, "header": "sp|Q2TBK7-1|RUSD3_BOVIN Isoform 1 of Mitochondrial mRNA pseudouridine synthase RPUSD3 OS=Bos taurus OX=9913 GN=RPUSD3 PE=2 SV=1 CANONICAL=Q2TBK7-1" }, "isoforms": [ { "isoform_ac": "Q2TBK7-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBK7/entry#Q2TBK7-1", "sequence": { "sequence": "MGGWRVLGQASGGWRRGLGIRATSTAAGFGTKARHQLQRRGASKPSDPPGDQPFPGLLRPGTFSREELVDVLRAAVVDSKGPLVTLNKPQGLPVTGKPGELTLLSVLPELSRSLGLGEQEVQVVRASGKEASGLVLLSSCSQTASRLQKFFTHSRRARKPTATYCAVTDGIPVTSEGKIQAALKLEHIDGVNLVVPVQSPSRKDIMEGVKRTLSHFRVVATGSGCALVQLQPLTVFPSQLQAHMALQLCPVLGDHTYSARVGTVLGQRFLLPVESTKPQRQVLDEALLGRLCLTASQAARLPLHLHLHCLRLPGARPRDPPIELLAPLPSYFSRTLQCLGLHYQ", "length": 344, "header": "sp|Q2TBK7-1|RUSD3_BOVIN Isoform 1 of Mitochondrial mRNA pseudouridine synthase RPUSD3 OS=Bos taurus OX=9913 GN=RPUSD3 PE=2 SV=1 CANONICAL=Q2TBK7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 64, "end_pos": 64, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK7", "url": "https://www.uniprot.org/uniprotkb/Q2TBK7" } ], "site_lbl": "Ser64" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:534606", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534606", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "enzyme-directed rRNA pseudouridine synthesis", "id": "GO:0000455", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000455", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK7", "url": "https://www.uniprot.org/uniprotkb/Q2TBK7" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK7", "url": "https://www.uniprot.org/uniprotkb/Q2TBK7" } ], "pmid": "" }, { "name": "positive regulation of mitochondrial translation", "id": "GO:0070131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070131", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK7", "url": "https://www.uniprot.org/uniprotkb/Q2TBK7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK7", "url": "https://www.uniprot.org/uniprotkb/Q2TBK7" } ], "pmid": "" }, { "name": "pseudouridine synthase activity", "id": "GO:0009982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009982", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK7", "url": "https://www.uniprot.org/uniprotkb/Q2TBK7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q2TBK7", "url": "https://www.uniprot.org/uniprotkb/Q2TBK7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "56644", "name": "", "equation": "a uridine in mRNA = a pseudouridine in mRNA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08DI8-1", "Q5E9Z1-1", "Q2TBK7-1", "E1BDL3-1", "A0AAA9T9C6-1" ], "evidence": [ { "id": "56644", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/56644" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9T9C6", "gene_name": "TRUB1", "activity": [ { "ec_number": "5.4.99.25", "activity": "uridine(55) in tRNA = pseudouridine(55) in tRNA.", "evidence": [ { "id": "A0AAA9T9C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6" } ] }, { "ec_number": "5.4.99.25", "activity": "", "evidence": [ { "id": "A0AAA9T9C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6" } ] } ] }, { "uniprot_ac": "E1BDL3", "gene_name": "PUS1", "activity": [ { "ec_number": "5.4.99.12", "activity": "uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA.", "evidence": [ { "id": "E1BDL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ] }, { "ec_number": "5.4.99.12", "activity": "", "evidence": [ { "id": "E1BDL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ] } ] }, { "uniprot_ac": "Q08DI8", "gene_name": "PUS7", "activity": [ { "ec_number": "5.4.99.-", "activity": "", "evidence": [ { "id": "Q08DI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI8" } ] } ] }, { "uniprot_ac": "Q2TBK7", "gene_name": "RPUSD3", "activity": [ { "ec_number": "5.4.99.-", "activity": "", "evidence": [ { "id": "Q2TBK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBK7" } ] } ] }, { "uniprot_ac": "Q5E9Z1", "gene_name": "RPUSD4", "activity": [ { "ec_number": "5.4.99.-", "activity": "", "evidence": [ { "id": "Q5E9Z1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z1" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBK7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 344, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBK7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBK7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 64 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBL6-1", "uniprot_ac": "Q2TBL6", "uniprot_id": "TALDO_BOVIN", "mass": { "chemical_mass": 37685.0, "monoisotopic_mass": 37685.0 }, "refseq": { "ac": "NP_001030360", "name": "transaldolase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030360" }, "gene_names": [ { "name": "TALDO1", "type": "recommended", "evidence": [ { "id": "Q2TBL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL6" } ] }, { "name": "TALDO1", "type": "synonym", "evidence": [ { "id": "NP_001030360", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030360" } ] } ], "protein_names": [ { "name": "Transaldolase", "type": "recommended", "evidence": [ { "id": "Q2TBL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL6/entry#names_and_taxonomy" } ] }, { "name": "2.2.1.2", "type": "synonym", "evidence": [ { "id": "Q2TBL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL6/entry#names_and_taxonomy" } ] }, { "name": "transaldolase", "type": "synonym", "evidence": [ { "id": "NP_001030360", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030360" } ] } ], "function": [ { "annotation": "Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedoheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL6", "url": "https://www.uniprot.org/uniprotkb/Q2TBL6#function" }, { "database": "UniProtKB", "id": "P37837", "url": "https://www.uniprot.org/uniprotkb/P37837#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBL6", "url": "https://www.uniprot.org/uniprotkb/Q2TBL6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TALDO1", "url": "https://www.uniprot.org/uniprotkb/Q2TBL6", "locus": { "chromosome": "29", "start_pos": 50591286, "end_pos": 50598649, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010336", "url": "https://www.ensembl.org/id/ENSBTAG00000010336" } ] } } ], "crossref": [ { "id": "Q2TBL6", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBL6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00957", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00957", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513453", "url": "https://www.ncbi.nlm.nih.gov/gene/513453", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001585", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001585", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004730", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004730", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513453", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513453", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBL6", "url": "https://www.orthodb.org/?gene=Q2TBL6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10683", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10683", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10683:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10683:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00923", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00923", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030360", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17053", "url": "https://www.rhea-db.org/rhea/17053", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBL6", "url": "https://www.uniprot.org/uniprotkb/Q2TBL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBL6-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBL6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGSPVKRQRMENALDQLKQFTTVVADTGDFHAIDEYKPQDATTNPSLILAAAQMPTYQELVEEAIAYGRKLGGSQEEQITNAIDKLFVLFGAEILKKIPGRVSTEVDARLSFDKDAMVARARRLIELYKEAGISKERILIKLSSTWEGIQAGKELEEHHGIRCNMTLLFSFAQAVACAEAGVTLISPFVGRILDWHVANTDKKSYETQEDPGVKSVTKIYNYYKKFGYKTIVMGASFRNTGEIKALAGCDFLTISPQLLGELLKDHSKLTPVLSAKAAQASDLEKIQLDEKAFRWLHNEDRMAVEKLSDGIRRFAADAVKLERMLRERMFSAENGK", "length": 337, "header": "sp|Q2TBL6-1|TALDO_BOVIN Isoform 1 of Transaldolase OS=Bos taurus OX=9913 GN=TALDO1 PE=2 SV=1 CANONICAL=Q2TBL6-1" }, "isoforms": [ { "isoform_ac": "Q2TBL6-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBL6/entry#Q2TBL6-1", "sequence": { "sequence": "MSGSPVKRQRMENALDQLKQFTTVVADTGDFHAIDEYKPQDATTNPSLILAAAQMPTYQELVEEAIAYGRKLGGSQEEQITNAIDKLFVLFGAEILKKIPGRVSTEVDARLSFDKDAMVARARRLIELYKEAGISKERILIKLSSTWEGIQAGKELEEHHGIRCNMTLLFSFAQAVACAEAGVTLISPFVGRILDWHVANTDKKSYETQEDPGVKSVTKIYNYYKKFGYKTIVMGASFRNTGEIKALAGCDFLTISPQLLGELLKDHSKLTPVLSAKAAQASDLEKIQLDEKAFRWLHNEDRMAVEKLSDGIRRFAADAVKLERMLRERMFSAENGK", "length": 337, "header": "sp|Q2TBL6-1|TALDO_BOVIN Isoform 1 of Transaldolase OS=Bos taurus OX=9913 GN=TALDO1 PE=2 SV=1 CANONICAL=Q2TBL6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 237, "end_pos": 237, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL6", "url": "https://www.uniprot.org/uniprotkb/Q2TBL6" } ], "site_lbl": "Ser237" }, { "start_pos": 256, "end_pos": 256, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL6", "url": "https://www.uniprot.org/uniprotkb/Q2TBL6" } ], "site_lbl": "Ser256" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:513453", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513453", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "pentose-phosphate shunt, non-oxidative branch", "id": "GO:0009052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009052", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL6", "url": "https://www.uniprot.org/uniprotkb/Q2TBL6" } ], "pmid": "" }, { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL6", "url": "https://www.uniprot.org/uniprotkb/Q2TBL6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL6", "url": "https://www.uniprot.org/uniprotkb/Q2TBL6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL6", "url": "https://www.uniprot.org/uniprotkb/Q2TBL6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transaldolase activity", "id": "GO:0004801", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004801", "evidence": [ { "database": "UniProtKB", "id": "Q2TBL6", "url": "https://www.uniprot.org/uniprotkb/Q2TBL6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17053", "name": "", "equation": "D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5C8-1", "Q2TBL6-1" ], "evidence": [ { "id": "17053", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17053" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "G5E5C8", "gene_name": "TALDO1", "activity": [ { "ec_number": "2.2.1.2", "activity": "D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate.", "evidence": [ { "id": "G5E5C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5C8" } ] }, { "ec_number": "2.2.1.2", "activity": "", "evidence": [ { "id": "G5E5C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5C8" } ] } ] }, { "uniprot_ac": "Q2TBL6", "gene_name": "TALDO1", "activity": [ { "ec_number": "2.2.1.2", "activity": "D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate.", "evidence": [ { "id": "Q2TBL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL6" } ] }, { "ec_number": "2.2.1.2", "activity": "", "evidence": [ { "id": "Q2TBL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL6" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBL6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 337, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBL6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBL6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.2.1.2", "ec_name": "D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate.", "evidence": [ { "id": "2.2.1.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.2.1.2" }, { "id": "2.2.1.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.2.1.2" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 237, 256 ], "sequon_annotation_sites": [ { "start_pos": 165, "end_pos": 167 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBN9-1", "uniprot_ac": "Q2TBN9", "uniprot_id": "IFT43_BOVIN", "mass": { "chemical_mass": 23440.0, "monoisotopic_mass": 23440.0 }, "refseq": { "ac": "NP_001035611", "name": "intraflagellar transport protein 43 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035611" }, "gene_names": [ { "name": "IFT43", "type": "recommended", "evidence": [ { "id": "Q2TBN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBN9" } ] }, { "name": "C10H14orf179", "type": "synonym", "evidence": [ { "id": "NP_001035611", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035611" } ] }, { "name": "C14orf179", "type": "synonym", "evidence": [ { "id": "NP_001035611", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035611" } ] }, { "name": "IFT43", "type": "synonym", "evidence": [ { "id": "NP_001035611", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035611" } ] } ], "protein_names": [ { "name": "Intraflagellar transport protein 43 homolog", "type": "recommended", "evidence": [ { "id": "Q2TBN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBN9/entry#names_and_taxonomy" } ] }, { "name": "intraflagellar transport 43 homolog", "type": "synonym", "evidence": [ { "id": "NP_001035611", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035611" } ] }, { "name": "intraflagellar transport protein 43 homolog", "type": "synonym", "evidence": [ { "id": "NP_001035611", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035611" } ] } ], "function": [ { "annotation": "As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN9", "url": "https://www.uniprot.org/uniprotkb/Q2TBN9#function" }, { "database": "UniProtKB", "id": "Q96FT9", "url": "https://www.uniprot.org/uniprotkb/Q96FT9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBN9", "url": "https://www.uniprot.org/uniprotkb/Q2TBN9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IFT43", "url": "https://www.uniprot.org/uniprotkb/Q2TBN9", "locus": { "chromosome": "10", "start_pos": 87371777, "end_pos": 87263882, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012005", "url": "https://www.ensembl.org/id/ENSBTAG00000012005" } ] } } ], "crossref": [ { "id": "Q2TBN9", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBN9", "database": "AlphaFoldDB", "categories": [] }, { "id": "513228", "url": "https://www.ncbi.nlm.nih.gov/gene/513228", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029302", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029302", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513228", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513228", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBN9", "url": "https://www.orthodb.org/?gene=Q2TBN9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR33724", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33724", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33724:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33724:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15305", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15305", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035611", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBN9", "url": "https://www.uniprot.org/uniprotkb/Q2TBN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBN9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBN9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDLLDLGEERRRCPATSGAKMGRRAQQESTQAENHLSGKNSSLTLTAEVPPPKPPRRQGRWAEASVKVSKSQRRASEEIQDHRLRQQSLDRSDDGGDIPVIPDLEEVQEEDFVLQVAAPPSIQVNRVMTYRDLDNDLMKYSAFQTLDGEIDLKLLTKVLAPEHEVREDDVSWDWDHLYTEVSSELLSEWDALQTEKEGPVGQPAHT", "length": 207, "header": "sp|Q2TBN9-1|IFT43_BOVIN Isoform 1 of Intraflagellar transport protein 43 homolog OS=Bos taurus OX=9913 GN=IFT43 PE=2 SV=1 CANONICAL=Q2TBN9-1" }, "isoforms": [ { "isoform_ac": "Q2TBN9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBN9/entry#Q2TBN9-1", "sequence": { "sequence": "MEDLLDLGEERRRCPATSGAKMGRRAQQESTQAENHLSGKNSSLTLTAEVPPPKPPRRQGRWAEASVKVSKSQRRASEEIQDHRLRQQSLDRSDDGGDIPVIPDLEEVQEEDFVLQVAAPPSIQVNRVMTYRDLDNDLMKYSAFQTLDGEIDLKLLTKVLAPEHEVREDDVSWDWDHLYTEVSSELLSEWDALQTEKEGPVGQPAHT", "length": 207, "header": "sp|Q2TBN9-1|IFT43_BOVIN Isoform 1 of Intraflagellar transport protein 43 homolog OS=Bos taurus OX=9913 GN=IFT43 PE=2 SV=1 CANONICAL=Q2TBN9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 77, "end_pos": 77, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN9", "url": "https://www.uniprot.org/uniprotkb/Q2TBN9" } ], "site_lbl": "Ser77" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513228", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513228", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN9", "url": "https://www.uniprot.org/uniprotkb/Q2TBN9" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN9", "url": "https://www.uniprot.org/uniprotkb/Q2TBN9" } ], "pmid": "" }, { "name": "intraciliary transport particle A", "id": "GO:0030991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030991", "evidence": [ { "database": "UniProtKB", "id": "Q2TBN9", "url": "https://www.uniprot.org/uniprotkb/Q2TBN9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cilium assembly", "id": 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"https://alphafold.ebi.ac.uk/entry/Q2TBN9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 77 ], "sequon_annotation_sites": [ { "start_pos": 41, "end_pos": 43 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBP0-1", "uniprot_ac": "Q2TBP0", "uniprot_id": "PSB7_BOVIN", "mass": { "chemical_mass": 30009.0, "monoisotopic_mass": 30009.0 }, "refseq": { "ac": "NP_001033616", "name": "proteasome subunit beta type-7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033616" }, "gene_names": [ { "name": "PSMB7", "type": "recommended", "evidence": [ { "id": "Q2TBP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0" } ] }, { "name": "PSMB7", "type": "synonym", "evidence": [ { "id": "NP_001033616", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033616" } ] } ], "protein_names": [ { "name": "Proteasome subunit beta type-7", "type": "recommended", "evidence": [ { "id": "Q2TBP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0/entry#names_and_taxonomy" } ] }, { "name": "3.4.25.1", "type": "synonym", "evidence": [ { "id": "Q2TBP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0/entry#names_and_taxonomy" } ] }, { "name": "proteasome (prosome, macropain) subunit, beta type, 7", "type": "synonym", "evidence": [ { "id": "NP_001033616", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033616" } ] }, { "name": "proteasome beta 7 subunit", "type": "synonym", "evidence": [ { "id": "NP_001033616", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033616" } ] }, { "name": "proteasome subunit beta 7", "type": "synonym", "evidence": [ { "id": "NP_001033616", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033616" } ] }, { "name": "proteasome subunit beta type-7", "type": "synonym", "evidence": [ { "id": "NP_001033616", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033616" } ] } ], "function": [ { "annotation": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP0", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0#function" }, { "database": "UniProtKB", "id": "Q99436", "url": "https://www.uniprot.org/uniprotkb/Q99436#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBP0", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSMB7", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0", "locus": { "chromosome": "11", "start_pos": 95402014, "end_pos": 95459424, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003067", "url": "https://www.ensembl.org/id/ENSBTAG00000003067" } ] } } ], "crossref": [ { "id": "Q2TBP0", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBP0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03763", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03763", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511207", "url": "https://www.ncbi.nlm.nih.gov/gene/511207", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "1IRU", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=1IRU&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "8AZK", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8AZK&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "8FZ5", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8FZ5&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "8FZ6", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8FZ6&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR000243", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000243", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001353", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001353", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024689", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024689", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511207", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511207", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBP0", "url": "https://www.orthodb.org/?gene=Q2TBP0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32194", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32194", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32194:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32194:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00001iru", "url": "https://www.rcsb.org/structure/pdb_00001iru", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00008azk", "url": "https://www.rcsb.org/structure/pdb_00008azk", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00008fz5", "url": "https://www.rcsb.org/structure/pdb_00008fz5", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00008fz6", "url": "https://www.rcsb.org/structure/pdb_00008fz6", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1IRU", "url": "https://www.rcsb.org/structure/1IRU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8AZK", "url": "https://www.rcsb.org/structure/8AZK", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8FZ5", "url": "https://www.rcsb.org/structure/8FZ5", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8FZ6", "url": "https://www.rcsb.org/structure/8FZ6", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00227", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00227", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12465", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12465", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033616", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBP0", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBP0-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAVSVYERPVGGFSFDNCRRNAVLEADFAKKGYKLPTARKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKKLVSEAIAAGIFNDLGSGSNIDLCVISKSKLDFLRPYSVPNKKGTRFGRYRCEKGTNAVLTEKVTTLEIEVLEETVQTMDTS", "length": 277, "header": "sp|Q2TBP0-1|PSB7_BOVIN Isoform 1 of Proteasome subunit beta type-7 OS=Bos taurus OX=9913 GN=PSMB7 PE=1 SV=1 CANONICAL=Q2TBP0-1" }, "isoforms": [ { "isoform_ac": "Q2TBP0-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0/entry#Q2TBP0-1", "sequence": { "sequence": "MAAVSVYERPVGGFSFDNCRRNAVLEADFAKKGYKLPTARKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKKLVSEAIAAGIFNDLGSGSNIDLCVISKSKLDFLRPYSVPNKKGTRFGRYRCEKGTNAVLTEKVTTLEIEVLEETVQTMDTS", "length": 277, "header": "sp|Q2TBP0-1|PSB7_BOVIN Isoform 1 of Proteasome subunit beta type-7 OS=Bos taurus OX=9913 GN=PSMB7 PE=1 SV=1 CANONICAL=Q2TBP0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The structure of the mammalian 20S proteasome at 2.75 A resolution.", "journal": "Structure", "date": "2002", "authors": "Unno Masaki, Mizushima Tsunehiro, Morimoto Yukio, Tomisugi Yoshikazu, Tanaka Keiji, Yasuoka Noritake, Tsukihara Tomitake", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP0", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0" } ], "reference": [ { "type": "PubMed", "id": "12015144", "url": "https://glygen.org/publication/PubMed/12015144" } ] } ], "pathway": [ { "id": "bta:511207", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511207", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "proteasome core complex, beta-subunit complex", "id": "GO:0019774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019774", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP0", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP0", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP0", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP0", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0" } ], "pmid": "" }, { "name": "proteasome core complex", "id": "GO:0005839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005839", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP0", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis involved in protein catabolic process", "id": "GO:0051603", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051603", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP0", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "threonine-type endopeptidase activity", "id": "GO:0004298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004298", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP0", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-9908786", "name": "Formation of bovine preholospermatoproteasome", "equation": "", "summary": "The 20S core particle of spermatoproteasome (20S sCP) can be purified from bovine testes, implying that two half-spermatoproteasomes join to form the preholospermatoproteasome that contains two inner and two outer rings (Zivkovic et al. 2022).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q2TBP0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-9908786", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9908786" } ] }, { "id": "R-BTA-9908803", "name": "Formation of bovine spermatoproteasome", "equation": "", "summary": "Based on a bovine study (Zivkovic et al. 2022), 19S is the predominant regulatory particle that is present in spermatoproteasomes (Zivkovic et al. 2022). A spermatoproteasome-specific proteasome activator PSME4 (PA200) is also a component of bovine spermatoproteasome (Zivkovic et al. 2022).", "cellular_location": "cytosol", "input_participant_list": [ "R-BTA-9909078" ], "output_participant_list": [ "R-BTA-9909073", "R-BTA-9909075", "R-BTA-9909082" ], "enzyme_list": [ "Q3MHN0-1", "Q2TBP0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-9908803", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9908803" } ] }, { "id": "R-NUL-9908837", "name": "hPSMF1 binds bovine 20S core particle", "equation": "", "summary": "Human PSMF1 (PI31) binds to the bovine 20S core particle (20S CP) (McCutchen-Maloney et al. 2000: human PSMF1 and bovine 20S CP were used; Hsu et al. 2023: human PSMF1 and bovine 20S CP were used; Wang et al. 2024: human PSMF1 and bovine 20S CP were used).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q2TBP0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-NUL-9908837", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-NUL-9908837" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-9909073", "participant_name": "bPSMD5 [cytosol]", "crossref": [ { "id": "Q0P5A6", "database": "UniProt", "url": "" }, { "id": "NP_001069161.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-BTA-9909075", "participant_name": "bPSMD10 [cytosol]", "crossref": [ { "id": "ENSBTAG00000013721", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000018226", "database": "ENSEMBL", "url": "" }, { "id": "A0A3S5ZP61", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000018226", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-9909078", "participant_name": "bPSME4 [cytosol]", "crossref": [ { "id": "F1MKX4", "database": "UniProt", "url": "" }, { "id": "33476", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-9909082", "participant_name": "bPAAF1 [cytosol]", "crossref": [ { "id": "ENSBTAP00000105697", "database": "ENSEMBL", "url": "" }, { "id": "NP_001069458.1", "database": "RefSeq", "url": "" }, { "id": "Q148I1", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000003679", "database": "ENSEMBL", "url": "" }, { "id": "54890", "database": "VGNC", "url": "" }, { "id": "ENSBTAT00000147648", "database": "ENSEMBL", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q2TBP0", "gene_name": "PSMB7", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "Q2TBP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "Q2TBP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0" } ] } ] }, { "uniprot_ac": "Q32KL2", "gene_name": "PSMB5", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "Q32KL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL2" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "Q32KL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL2" } ] } ] }, { "uniprot_ac": "Q3MHN0", "gene_name": "PSMB6", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "Q3MHN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHN0" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "Q3MHN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHN0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBP0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 277, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBP0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBP0" }, { "pdb_id": "1iru", "pdb_chain": "i/w", "start_pos": 44, "end_pos": 277, "overlap": "0.84", "method": "X-Ray_Crystallography", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/1iru.pdb", "url_external": "https://www.rcsb.org/structure/1iru" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.25.1", "ec_name": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "3.4.25.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.25.1" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 73, "end_pos": 75 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { 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"title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2TBP1-1", "uniprot_ac": "Q2TBP1", "uniprot_id": "DDX25_BOVIN", "mass": { "chemical_mass": 54619.0, "monoisotopic_mass": 54619.0 }, "refseq": { "ac": "NP_001033606", "name": "ATP-dependent RNA helicase DDX25", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033606" }, "gene_names": [ { "name": "DDX25", "type": "recommended", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] }, { "name": "DDX25", "type": "synonym", "evidence": [ { "id": "NP_001033606", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033606" } ] } ], "protein_names": [ { "name": "ATP-dependent RNA helicase DDX25", "type": "recommended", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1/entry#names_and_taxonomy" } ] }, { "name": "3.6.4.13", "type": "synonym", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1/entry#names_and_taxonomy" } ] }, { "name": "ATP-dependent RNA helicase DDX25", "type": "synonym", "evidence": [ { "id": "NP_001033606", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033606" } ] }, { "name": "DEAD (Asp-Glu-Ala-Asp) box helicase 25", "type": "synonym", "evidence": [ { "id": "NP_001033606", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033606" } ] }, { "name": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 25", "type": "synonym", "evidence": [ { "id": "NP_001033606", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033606" } ] }, { "name": "DEAD box protein 25", "type": "synonym", "evidence": [ { "id": "NP_001033606", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033606" }, { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBP1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DDX25", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1", "locus": { "chromosome": "29", "start_pos": 29279562, "end_pos": 29259552, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004266", "url": "https://www.ensembl.org/id/ENSBTAG00000004266" } ] } } ], "crossref": [ { "id": "Q2TBP1", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBP1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd18787", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18787", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508962", "url": "https://www.ncbi.nlm.nih.gov/gene/508962", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508962", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508962", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBP1", "url": "https://www.orthodb.org/?gene=Q2TBP1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47958", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47958", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00270", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00270", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033606", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBP1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBP1-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASLLWGGDAGAAESERLNGHFSNLIHPQNHLLGIKSATIPNIDGSVNRIEEDDEDDVVDLAANSLLNKLIRQSLVESSHRVEVLQKDPSSPLYSVKTFEELRLKEELLKGIYAMGFNRPSKIQEMALPMMLAHPPQNLIAQSQSGTGKTAAFVLAMLSRVNALKLFPQCLCLAPTYELALQTGRVVERMGKFCVDVQVMYAIRGNRIPRGTDVTKQIVIGTPGTVLDWCFKRKLIDLTKIRVFVLDEADVMIDTQGFEDQSIRIQRALPSECQMLLFSATFEDSVWQFAERIIPDPNVIKLRKEELTLNNIRQYYVLCGNRKDKYQALCNIYGGITIGQAIIFCQTRRNAKWLTVEMMQDGHQVSLLSGELTVDQRASIIQRFRDGKEKVLITTNVCARGIDVKQVTIVVNFDLPVNQAEEPDYETYLHRIGRTGRFGKKGLAFNMIEVDKLPLLMKIQDHFNSSIKQLDPEDMDEIEKIEY", "length": 483, "header": "sp|Q2TBP1-1|DDX25_BOVIN Isoform 1 of ATP-dependent RNA helicase DDX25 OS=Bos taurus OX=9913 GN=DDX25 PE=2 SV=1 CANONICAL=Q2TBP1-1" }, "isoforms": [ { "isoform_ac": "Q2TBP1-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1/entry#Q2TBP1-1", "sequence": { "sequence": "MASLLWGGDAGAAESERLNGHFSNLIHPQNHLLGIKSATIPNIDGSVNRIEEDDEDDVVDLAANSLLNKLIRQSLVESSHRVEVLQKDPSSPLYSVKTFEELRLKEELLKGIYAMGFNRPSKIQEMALPMMLAHPPQNLIAQSQSGTGKTAAFVLAMLSRVNALKLFPQCLCLAPTYELALQTGRVVERMGKFCVDVQVMYAIRGNRIPRGTDVTKQIVIGTPGTVLDWCFKRKLIDLTKIRVFVLDEADVMIDTQGFEDQSIRIQRALPSECQMLLFSATFEDSVWQFAERIIPDPNVIKLRKEELTLNNIRQYYVLCGNRKDKYQALCNIYGGITIGQAIIFCQTRRNAKWLTVEMMQDGHQVSLLSGELTVDQRASIIQRFRDGKEKVLITTNVCARGIDVKQVTIVVNFDLPVNQAEEPDYETYLHRIGRTGRFGKKGLAFNMIEVDKLPLLMKIQDHFNSSIKQLDPEDMDEIEKIEY", "length": 483, "header": "sp|Q2TBP1-1|DDX25_BOVIN Isoform 1 of ATP-dependent RNA helicase DDX25 OS=Bos taurus OX=9913 GN=DDX25 PE=2 SV=1 CANONICAL=Q2TBP1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:508962", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508962", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "poly(A)+ mRNA export from nucleus", "id": "GO:0016973", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016973", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ], "pmid": "" }, { "name": "mRNA export from nucleus", "id": "GO:0006406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006406", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ], "pmid": "" }, { "name": "regulation of translation", "id": "GO:0006417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006417", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ], "pmid": "" }, { "name": "spermatid development", "id": "GO:0007286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": 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"evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": 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"evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": 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{ "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": 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"activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": 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{ "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] } ] }, { "uniprot_ac": "Q29S22", "gene_name": "DDX47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { 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"NP_001033620", "name": "histone H4 transcription factor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033620" }, "gene_names": [ { "name": "HINFP", "type": "recommended", "evidence": [ { "id": "Q2TBP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2" } ] }, { "name": "HINFP", "type": "synonym", "evidence": [ { "id": "NP_001033620", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033620" } ] }, { "name": "MIZF", "type": "synonym", "evidence": [ { "id": "NP_001033620", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033620" }, { "id": "Q2TBP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2" } ] } ], "protein_names": [ { "name": "Histone H4 transcription factor", "type": "recommended", "evidence": [ { "id": "Q2TBP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2/entry#names_and_taxonomy" } ] }, { "name": "HiNF-P", "type": "synonym", "evidence": [ { "id": "Q2TBP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2/entry#names_and_taxonomy" } ] }, { "name": "Histone nuclear factor P", "type": "synonym", "evidence": [ { "id": "Q2TBP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2/entry#names_and_taxonomy" } ] }, { "name": "MBD2-interacting zinc finger protein", "type": "synonym", "evidence": [ { "id": "NP_001033620", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033620" }, { "id": "Q2TBP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2/entry#names_and_taxonomy" } ] }, { "name": "Methyl-CpG-binding protein 2-interacting zinc finger protein", "type": "synonym", "evidence": [ { "id": "Q2TBP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2/entry#names_and_taxonomy" } ] }, { "name": "hiNF-P", "type": "synonym", "evidence": [ { "id": "NP_001033620", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033620" } ] }, { "name": "histone H4 transcription factor", "type": "synonym", "evidence": [ { "id": "NP_001033620", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033620" } ] }, { "name": "histone nuclear factor P", "type": "synonym", "evidence": [ { "id": "NP_001033620", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033620" } ] }, { "name": "methyl-CpG-binding protein 2-interacting zinc finger protein", "type": "synonym", "evidence": [ { "id": "NP_001033620", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033620" } ] } ], "function": [ { "annotation": "Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP2", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBP2", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HINFP", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2", "locus": { "chromosome": "15", "start_pos": 29709232, "end_pos": 29699175, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015015", "url": "https://www.ensembl.org/id/ENSBTAG00000015015" } ] } } ], "crossref": [ { "id": "Q2TBP2", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBP2", "database": "AlphaFoldDB", "categories": [] }, { "id": "511965", "url": "https://www.ncbi.nlm.nih.gov/gene/511965", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051574", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051574", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511965", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511965", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBP2", "url": "https://www.orthodb.org/?gene=Q2TBP2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24391", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24391", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24391:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24391:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13894", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13894", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033620", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBP2", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBP2-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPPPGKVPRKENLGLQCEWGSCSFVCSAMEEFCEHVTQHLQQHLQGSGEEEEEEEDLLEEEFSCLWRECGFCSPDNSADLIRHVYFHCYHTKLKQWGLQALQSQADLSPCILDFQSRNLIPDIPDHFLCLWEHCENSFDNPEWFYRHVEAHSQCCEYQVVGKDNNVVLCGWKGCTCTFKDRFKLREHLRSHTQEKVVACPTCGGMFANNTKFLDHIRRQSSLDQQHFQCSHCSKRFATERLLRDHMRNHVNHYKCPLCDMTCPLPSSLRNHMRFRHSEARPFKCDCCDYSCKNLIDLRKHLDTHSKEPAYSCDFENCTFSARSLYSIKSHYRKVHEGDSEPRYRCHVCDKCFTRGNNLTVHLRKKHQFKWPSGHPRFRYKEHEDGYMRLQLVRYESVELTQQLLRQPQEGSGLGASLNESSLQDIILETVPGEPGPQEEAEEEGGGGEGIALPASQGTSSPIIHVVNQTNAQGEREVVYYVLFEAPGEPPPASEPPSGGVMGELQGAAEEPEVQMV", "length": 516, "header": "sp|Q2TBP2-1|HINFP_BOVIN Isoform 1 of Histone H4 transcription factor OS=Bos taurus OX=9913 GN=HINFP PE=2 SV=1 CANONICAL=Q2TBP2-1" }, "isoforms": [ { "isoform_ac": "Q2TBP2-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2/entry#Q2TBP2-1", "sequence": { "sequence": "MPPPGKVPRKENLGLQCEWGSCSFVCSAMEEFCEHVTQHLQQHLQGSGEEEEEEEDLLEEEFSCLWRECGFCSPDNSADLIRHVYFHCYHTKLKQWGLQALQSQADLSPCILDFQSRNLIPDIPDHFLCLWEHCENSFDNPEWFYRHVEAHSQCCEYQVVGKDNNVVLCGWKGCTCTFKDRFKLREHLRSHTQEKVVACPTCGGMFANNTKFLDHIRRQSSLDQQHFQCSHCSKRFATERLLRDHMRNHVNHYKCPLCDMTCPLPSSLRNHMRFRHSEARPFKCDCCDYSCKNLIDLRKHLDTHSKEPAYSCDFENCTFSARSLYSIKSHYRKVHEGDSEPRYRCHVCDKCFTRGNNLTVHLRKKHQFKWPSGHPRFRYKEHEDGYMRLQLVRYESVELTQQLLRQPQEGSGLGASLNESSLQDIILETVPGEPGPQEEAEEEGGGGEGIALPASQGTSSPIIHVVNQTNAQGEREVVYYVLFEAPGEPPPASEPPSGGVMGELQGAAEEPEVQMV", "length": 516, "header": "sp|Q2TBP2-1|HINFP_BOVIN Isoform 1 of Histone H4 transcription factor OS=Bos taurus OX=9913 GN=HINFP PE=2 SV=1 CANONICAL=Q2TBP2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511965", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511965", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP2", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP2", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP2", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP2", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP2", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP2", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP2", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP2", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP2", "url": "https://www.uniprot.org/uniprotkb/Q2TBP2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" }, { "start_pos": 316, "end_pos": 318, "annotation": "n_glycosylation_sequon" }, { "start_pos": 357, "end_pos": 359, "annotation": "n_glycosylation_sequon" }, { "start_pos": 418, "end_pos": 420, "annotation": "n_glycosylation_sequon" }, { "start_pos": 467, "end_pos": 469, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBP2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 516, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBP2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBP2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 208, "end_pos": 210 }, { "start_pos": 316, "end_pos": 318 }, { "start_pos": 357, "end_pos": 359 }, { "start_pos": 418, "end_pos": 420 }, { "start_pos": 467, "end_pos": 469 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBP8-1", "uniprot_ac": "Q2TBP8", "uniprot_id": "MET17_BOVIN", "mass": { "chemical_mass": 51557.0, "monoisotopic_mass": 51557.0 }, "refseq": { "ac": "NP_001033631", "name": "ribosome assembly protein METTL17, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033631" }, "gene_names": [ { "name": "METTL17", "type": "recommended", "evidence": [ { "id": "Q2TBP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP8" } ] }, { "name": "METT11D1", "type": "synonym", "evidence": [ { "id": "NP_001033631", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033631" } ] }, { "name": "METTL17", "type": "synonym", "evidence": [ { "id": "NP_001033631", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033631" } ] } ], "protein_names": [ { "name": "Ribosome assembly protein METTL17, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q2TBP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP8/entry#names_and_taxonomy" } ] }, { "name": "Methyltransferase-like protein 17", "type": "synonym", "evidence": [ { "id": "Q2TBP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP8/entry#names_and_taxonomy" } ] }, { "name": "methyltransferase 11 domain containing 1", "type": "synonym", "evidence": [ { "id": "NP_001033631", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033631" } ] }, { "name": "methyltransferase 11 domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001033631", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033631" } ] }, { "name": "methyltransferase-like protein 17, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001033631", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033631" } ] }, { "name": "protein RSM22 homolog, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001033631", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033631" } ] }, { "name": "ribosome assembly protein METTL17, mitochondrial precursor", "type": "synonym", "evidence": [ { "id": "NP_001033631", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033631" } ] }, { "name": "ribosome assembly protein METTL17, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001033631", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033631" } ] } ], "function": [ { "annotation": "Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP8", "url": "https://www.uniprot.org/uniprotkb/Q2TBP8#function" }, { "database": "UniProtKB", "id": "Q9H7H0", "url": "https://www.uniprot.org/uniprotkb/Q9H7H0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBP8", "url": "https://www.uniprot.org/uniprotkb/Q2TBP8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "METTL17", "url": "https://www.uniprot.org/uniprotkb/Q2TBP8", "locus": { "chromosome": "10", "start_pos": 26119572, "end_pos": 26125218, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006613", "url": "https://www.ensembl.org/id/ENSBTAG00000006613" } ] } } ], "crossref": [ { "id": "Q2TBP8", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBP8", "database": "AlphaFoldDB", "categories": [] }, { "id": "514880", "url": "https://www.ncbi.nlm.nih.gov/gene/514880", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR015324", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015324", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052571", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052571", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514880", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514880", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBP8", "url": "https://www.orthodb.org/?gene=Q2TBP8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13184", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13184", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13184:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13184:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09243", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09243", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033631", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBP8", "url": "https://www.uniprot.org/uniprotkb/Q2TBP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBP8-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATGRGSRYLLTIGRWRRSFGIAPQFRALAALVPGVSHVDNKSDFLGKRPHRRHPGILQLSCVRLPQALAEAGQLLLLGSAMPNMEKQVQALTNYLWSRHLPVEPEELQRRAVLLEKKILENADSCQTEKHHEEILHALRRTTYHWQELSYSEGLSLVYMAARLDGGFAAVSRAFHEIQARLPEFQPQTLMDFGSGTGSVTWAAHSTWGQSLREYMCVDSSAAMLELAEKLLKGGSGSGMPCVPGVFFRQFLPVSPKVQFDVVVAAFSLSELPSKADRTDVVQTLWRKTGHFLVLIENGTKAGHSLLMDARDLVLNGKEKSPLDPRPGFVFAPCPHELPCPQLTASKPLACSFSQAYYPIPFSWNKKPKEEKFSLVILARGSPEKANRWPRITQPVLKRPRHVHCHLCCPDGHMQHAVITARRHGRDLYRCARVSSWGDLLPVITPLELPPSAQDAQDAPES", "length": 462, "header": "sp|Q2TBP8-1|MET17_BOVIN Isoform 1 of Ribosome assembly protein METTL17, mitochondrial OS=Bos taurus OX=9913 GN=METTL17 PE=2 SV=1 CANONICAL=Q2TBP8-1" }, "isoforms": [ { "isoform_ac": "Q2TBP8-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBP8/entry#Q2TBP8-1", "sequence": { "sequence": "MATGRGSRYLLTIGRWRRSFGIAPQFRALAALVPGVSHVDNKSDFLGKRPHRRHPGILQLSCVRLPQALAEAGQLLLLGSAMPNMEKQVQALTNYLWSRHLPVEPEELQRRAVLLEKKILENADSCQTEKHHEEILHALRRTTYHWQELSYSEGLSLVYMAARLDGGFAAVSRAFHEIQARLPEFQPQTLMDFGSGTGSVTWAAHSTWGQSLREYMCVDSSAAMLELAEKLLKGGSGSGMPCVPGVFFRQFLPVSPKVQFDVVVAAFSLSELPSKADRTDVVQTLWRKTGHFLVLIENGTKAGHSLLMDARDLVLNGKEKSPLDPRPGFVFAPCPHELPCPQLTASKPLACSFSQAYYPIPFSWNKKPKEEKFSLVILARGSPEKANRWPRITQPVLKRPRHVHCHLCCPDGHMQHAVITARRHGRDLYRCARVSSWGDLLPVITPLELPPSAQDAQDAPES", "length": 462, "header": "sp|Q2TBP8-1|MET17_BOVIN Isoform 1 of Ribosome assembly protein METTL17, mitochondrial OS=Bos taurus OX=9913 GN=METTL17 PE=2 SV=1 CANONICAL=Q2TBP8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514880", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514880", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial small ribosomal subunit", "id": "GO:0005763", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005763", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP8", "url": "https://www.uniprot.org/uniprotkb/Q2TBP8" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP8", "url": "https://www.uniprot.org/uniprotkb/Q2TBP8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP8", "url": "https://www.uniprot.org/uniprotkb/Q2TBP8" } ], "pmid": "" }, { "name": "4 iron, 4 sulfur cluster binding", "id": "GO:0051539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051539", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP8", "url": "https://www.uniprot.org/uniprotkb/Q2TBP8" } ], "pmid": "" }, { "name": "methyltransferase activity", "id": "GO:0008168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008168", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP8", "url": "https://www.uniprot.org/uniprotkb/Q2TBP8" } ], "pmid": "" }, { "name": "S-adenosyl-L-methionine binding", "id": "GO:1904047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904047", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP8", "url": "https://www.uniprot.org/uniprotkb/Q2TBP8" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP8", "url": "https://www.uniprot.org/uniprotkb/Q2TBP8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP8", "url": "https://www.uniprot.org/uniprotkb/Q2TBP8" } ], "pmid": "" }, { "name": "ribosomal small subunit biogenesis", "id": "GO:0042274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042274", "evidence": [ { "database": "UniProtKB", "id": "Q2TBP8", "url": "https://www.uniprot.org/uniprotkb/Q2TBP8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" }, { "start_pos": 41, "end_pos": 43, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBP8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 462, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBP8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBP8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 298, "end_pos": 300 }, { "start_pos": 41, "end_pos": 43 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBQ3-1", "uniprot_ac": "Q2TBQ3", "uniprot_id": "GAMT_BOVIN", "mass": { "chemical_mass": 26610.0, "monoisotopic_mass": 26610.0 }, "refseq": { "ac": "NP_001033633", "name": "guanidinoacetate N-methyltransferase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033633" }, "gene_names": [ { "name": "GAMT", "type": "recommended", "evidence": [ { "id": "Q2TBQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ3" } ] }, { "name": "GAMT", "type": "synonym", "evidence": [ { "id": "NP_001033633", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033633" } ] } ], "protein_names": [ { "name": "Guanidinoacetate N-methyltransferase", "type": "recommended", "evidence": [ { "id": "Q2TBQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ3/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.2", "type": "synonym", "evidence": [ { "id": "Q2TBQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ3/entry#names_and_taxonomy" } ] }, { "name": "guanidinoacetate N-methyltransferase", "type": "synonym", "evidence": [ { "id": "NP_001033633", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033633" } ] } ], "function": [ { "annotation": "Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor. Important in nervous system development.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ3", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ3#function" }, { "database": "UniProtKB", "id": "Q14353", "url": "https://www.uniprot.org/uniprotkb/Q14353#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ3", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GAMT", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ3", "locus": { "chromosome": "7", "start_pos": 43814689, "end_pos": 43817695, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004112", "url": "https://www.ensembl.org/id/ENSBTAG00000004112" } ] } } ], "crossref": [ { "id": "Q2TBQ3", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBQ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004112", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004112", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515270", "url": "https://www.ncbi.nlm.nih.gov/gene/515270", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016550", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016550", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026480", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026480", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515270", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515270", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HKMITPT", "url": "https://omabrowser.org/oma/group/HKMITPT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBQ3", "url": "https://www.orthodb.org/?gene=Q2TBQ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32379", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32379", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32379:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32379:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27704", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27704", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-71288", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71288", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001033633", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033633", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10656", "url": "https://www.rhea-db.org/rhea/10656", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBQ3", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBQ3-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAPAATPIFAPGENCSPAWRAAPAAYDASDTHLQILGKPVMERWETPYMHALAAAAASRGGRVLEVGFGMAIAATKVQEAPIEEHWIIECNEGVFQRLQDWALQQPHKVVPLKGLWEEVAPTLPDSHFDGILYDTYPLSEETWHTHQFNFIRDHAFRLLKPGGVLTYCNLTSWGELMKTKYSDITTMFEETQVPALLEAGFRRDNIRTQVMELVPPANCRYYAFPRMITPLVTKH", "length": 236, "header": "sp|Q2TBQ3-1|GAMT_BOVIN Isoform 1 of Guanidinoacetate N-methyltransferase OS=Bos taurus OX=9913 GN=GAMT PE=2 SV=1 CANONICAL=Q2TBQ3-1" }, "isoforms": [ { "isoform_ac": "Q2TBQ3-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ3/entry#Q2TBQ3-1", "sequence": { "sequence": "MSAPAATPIFAPGENCSPAWRAAPAAYDASDTHLQILGKPVMERWETPYMHALAAAAASRGGRVLEVGFGMAIAATKVQEAPIEEHWIIECNEGVFQRLQDWALQQPHKVVPLKGLWEEVAPTLPDSHFDGILYDTYPLSEETWHTHQFNFIRDHAFRLLKPGGVLTYCNLTSWGELMKTKYSDITTMFEETQVPALLEAGFRRDNIRTQVMELVPPANCRYYAFPRMITPLVTKH", "length": 236, "header": "sp|Q2TBQ3-1|GAMT_BOVIN Isoform 1 of Guanidinoacetate N-methyltransferase OS=Bos taurus OX=9913 GN=GAMT PE=2 SV=1 CANONICAL=Q2TBQ3-1" }, "locus": { "chromosome": "7", "start_pos": 43817657, "end_pos": 43814892, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005375.5", "url": "https://www.ensembl.org/id/ENSBTAT00000005375.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005375.3", "url": "https://www.ensembl.org/id/ENSBTAP00000005375.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:515270", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515270", "resource": "KEGG Pathway" }, { "id": "R-BTA-71288", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71288", "resource": "Reactome", "description": "Creatine metabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZU36-1", "protein_name": "Guanidinoacetate N-methyltransferase", "gene_name": "GAMT", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSAPSATPIFAPGENCSPAWRAAPAAYDASDTHLQILGKPVMERWETPYMHALAAVAASKGGRVLEVGFGMAIAATKVQEGAIDEHWIIECNDGVFQRLQDWAQQQPHKVVPLKGLWEEVAPTLPDSHFDGILYDTYPLSEETWHTHQFNFIREHAFRLLKPGGVLTYCNLTSWGELMKSKYSDITTMFQETQVPALLEAGFRQENIRTQVMELVPPADCRYYAFPQMITPLVTKQ", "length": 236 }, "evidence": [ { "id": "Q2TBQ3", "url": "https://omabrowser.org/oma/group/Q2TBQ3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V1AJ01-1", "protein_name": "guanidinoacetate N-methyltransferase", "gene_name": "GAMT", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSTRSDTAPIFTEGEDCKAAWQEATAAYDAPDTHLEILGKPVMERWETPYMHSLATVAASRGGRVLEVGFGMAIAATKVQEFNIEEHWIVECNDGVFQRLEEWARVQPHKVVPLKGLWEDVVPTLPDGHFSGILYDTYPLSAQTWHTHQFAFIKDHAFRLLRPGGVLTYCNLTSWGELLKGKYSDIEKMFEETQVAQLLEAGFRRENISTAVMELVPPRECRYYSFPRMITPRVVKH", "length": 237 }, "evidence": [ { "id": "Q2TBQ3", "url": "https://omabrowser.org/oma/group/Q2TBQ3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O35969-1", "protein_name": "Guanidinoacetate N-methyltransferase", "gene_name": "Gamt", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSSAASPLFAPGEDCGPAWRAAPAAYDASDTHLQILGKPVMERWETPYMHALAAAAASRGGRVLEVGFGMAIAASRVQQAPIEEHWIIECNDGVFQRLQDWALRQPHKVVPLKGLWEEVAPTLPDGHFDGILYDTYPLSEEAWHTHQFNFIKNHAFRLLKTGGVLTYCNLTSWGELMKSKYTDITTMFEETQVPALQEAGFLKENICTEVMALVPPADCRYYAFPQMITPLVTKH", "length": 236 }, "evidence": [ { "id": "Q2TBQ3", "url": "https://omabrowser.org/oma/group/Q2TBQ3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P10868-1", "protein_name": "Guanidinoacetate N-methyltransferase", "gene_name": "Gamt", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSSAASPLFAPGEDCGPAWRAAPAAYDTSDTHLQILGKPVMERWETPYMHSLAAAAASRGGRVLEVGFGMAIAASRVQQAPIKEHWIIECNDGVFQRLQNWALKQPHKVVPLKGLWEEEAPTLPDGHFDGILYDTYPLSEETWHTHQFNFIKTHAFRLLKPGGILTYCNLTSWGELMKSKYTDITAMFEETQVPALLEAGFQRENICTEVMALVPPADCRYYAFPQMITPLVTKH", "length": 236 }, "evidence": [ { "id": "Q2TBQ3", "url": "https://omabrowser.org/oma/group/Q2TBQ3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q14353-1", "protein_name": "Guanidinoacetate N-methyltransferase", "gene_name": "GAMT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSAPSATPIFAPGENCSPAWGAAPAAYDAADTHLRILGKPVMERWETPYMHALAAAASSKGGRVLEVGFGMAIAASKVQEAPIDEHWIIECNDGVFQRLRDWAPRQTHKVIPLKGLWEDVAPTLPDGHFDGILYDTYPLSEETWHTHQFNFIKNHAFRLLKPGGVLTYCNLTSWGELMKSKYSDITIMFEETQVPALLEAGFRRENIRTEVMALVPPADCRYYAFPQMITPLVTKG", "length": 236 }, "evidence": [ { "id": "Q2TBQ3", "url": "https://omabrowser.org/oma/group/Q2TBQ3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q71N41-1", "protein_name": "Guanidinoacetate N-methyltransferase", "gene_name": "gamt", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSAAQPIFSKGENCKQVWHDANADYNAADTHLEIMGKPVMERWETPYMHSLATVAASKGGRVLEIGFGMAIAATKVESFPIEEHWIIECNDGVFQRLQEWAKSQPHKVVPLKGLWEEVAPTLPDNHFDGILYDTYPLSEETWHTHQFNFIKAHAHRMLKPGGVLTYCNLTSWGELLKNKYDNIDKMFQETQVPHLLEAGFKKEKISTTLMDISPPSECKYYSFNKMITPTIIKE", "length": 234 }, "evidence": [ { "id": "Q2TBQ3", "url": "https://omabrowser.org/oma/group/Q2TBQ3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanidinoacetate N-methyltransferase activity", "id": "GO:0030731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030731", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ3", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ3", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ3", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ3", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ3" } ], "pmid": "" }, { "name": "creatine biosynthetic process", "id": "GO:0006601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006601", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ3", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" }, { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10656", "name": "", "equation": "guanidinoacetate + S-adenosyl-L-methionine = creatine + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2TBQ3-1" ], "evidence": [ { "id": "10656", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10656" } ] }, { "id": "R-BTA-71286", "name": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-30401", "R-ALL-71284" ], "output_participant_list": [], "enzyme_list": [ "Q2TBQ3-1" ], "evidence": [ { "id": "R-BTA-71286", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71286" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-30401", "participant_name": "GAA [cytosol]", "crossref": [ { "id": "57742", "database": "ChEBI", "url": "" }, { "id": "ZINC000000895314", "database": "ZINC", "url": "" }, { "id": "C00581", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-71284", "participant_name": "AdoMet [cytosol]", "crossref": [ { "id": "59789", "database": "ChEBI", "url": "" }, { "id": "C00019", "database": "COMPOUND", "url": "" }, { "id": "8145813", "database": "PubChem Substance", "url": "" }, { "id": "ZINC000004228231", "database": "ZINC", "url": "" }, { "id": "ZINC000004214738", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q2TBQ3", "gene_name": "GAMT", "activity": [ { "ec_number": "2.1.1.2", "activity": "guanidinoacetate + S-adenosyl-L-methionine = creatine + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "Q2TBQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ3" } ] }, { "ec_number": "2.1.1.2", "activity": "", "evidence": [ { "id": "Q2TBQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ3" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBQ3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 236, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBQ3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBQ3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2TBQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ3" }, { "id": "PRU00892", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00892" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RMT2", "eco_id": "ECO_0000255", "start_pos": 13, "end_pos": 236, "start_aa": "Gly", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.1.1.2", "ec_name": "guanidinoacetate + S-adenosyl-L-methionine = creatine + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "2.1.1.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.2" }, { "id": "2.1.1.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.2" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 15, "end_pos": 17 }, { "start_pos": 170, "end_pos": 172 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBQ5-1", "uniprot_ac": "Q2TBQ5", "uniprot_id": "RL7A_BOVIN", "mass": { "chemical_mass": 30026.0, "monoisotopic_mass": 30026.0 }, "refseq": { "ac": "NP_001035610", "name": "large ribosomal subunit protein eL8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035610" }, "gene_names": [ { "name": "RPL7A", "type": "recommended", "evidence": [ { "id": "Q2TBQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ5" } ] }, { "name": "RPL7A", "type": "synonym", "evidence": [ { "id": "NP_001035610", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035610" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein eL8", "type": "recommended", "evidence": [ { "id": "Q2TBQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ5/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L7a", "type": "synonym", "evidence": [ { "id": "NP_001035610", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035610" }, { "id": "Q2TBQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ5/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein eL8", "type": "synonym", "evidence": [ { "id": "NP_001035610", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035610" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ5", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ5#function" }, { "database": "UniProtKB", "id": "P62424", "url": "https://www.uniprot.org/uniprotkb/P62424#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ5", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL7A", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ5", "locus": { "chromosome": "11", "start_pos": 104259161, "end_pos": 104255845, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011559", "url": "https://www.ensembl.org/id/ENSBTAG00000011559" } ] } } ], "crossref": [ { "id": "Q2TBQ5", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBQ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011559", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011559", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513128", "url": "https://www.ncbi.nlm.nih.gov/gene/513128", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q2TBQ5", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q2TBQ5*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001921", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001921", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004037", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004037", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018492", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018492", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050257", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050257", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513128", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513128", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RMVKWPA", "url": "https://omabrowser.org/oma/group/RMVKWPA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBQ5", "url": "https://www.orthodb.org/?gene=Q2TBQ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23105", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23105", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01248", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01248", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035610", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBQ5", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBQ5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCIIKGKARLGRLVHRKTCTTVAFTQVNSEDKSALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG", "length": 266, "header": "sp|Q2TBQ5-1|RL7A_BOVIN Isoform 1 of Large ribosomal subunit protein eL8 OS=Bos taurus OX=9913 GN=RPL7A PE=2 SV=3 CANONICAL=Q2TBQ5-1" }, "isoforms": [ { "isoform_ac": "Q2TBQ5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ5/entry#Q2TBQ5-1", "sequence": { "sequence": "MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCIIKGKARLGRLVHRKTCTTVAFTQVNSEDKSALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG", "length": 266, "header": "sp|Q2TBQ5-1|RL7A_BOVIN Isoform 1 of Large ribosomal subunit protein eL8 OS=Bos taurus OX=9913 GN=RPL7A PE=2 SV=3 CANONICAL=Q2TBQ5-1" }, "locus": { "chromosome": "11", "start_pos": 104259104, "end_pos": 104255871, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015358.5", "url": "https://www.ensembl.org/id/ENSBTAT00000015358.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015358.3", "url": "https://www.ensembl.org/id/ENSBTAP00000015358.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ5", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:513128", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513128", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P12970-1", "protein_name": "Large ribosomal subunit protein eL8", "gene_name": "Rpl7a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCIIKGKARLGHLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG", "length": 266 }, "evidence": [ { "id": "Q2TBQ5", "url": "https://omabrowser.org/oma/group/Q2TBQ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P29453-1", "protein_name": "Large ribosomal subunit protein eL8B", "gene_name": "RPL8B", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAPGKKVAPAPFGAKSTKSNKAKNPLTHSTPKNFGIGQAVQPKRNLSRYVKWPEYVRLQRQKKILSIRLKVPPTIAQFQYTLDRNTAAETFKLFNKYRPETAAEKKERLTKEAAAIAEGKSKQDASPKPYAVKYGLNHVVSLIENKKAKLVLIANDVDPIELVVFLPALCKKMGVPYAIIKGKARLGTLVNQKTSAVAALTEVRAEDEAALAKLVSTIDANFADKYDEVKKHWGGGILGNKAQAKMDKRAKTSDSA", "length": 256 }, "evidence": [ { "id": "Q2TBQ5", "url": "https://omabrowser.org/oma/group/Q2TBQ5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P32429-1", "protein_name": "Large ribosomal subunit protein eL8", "gene_name": "RPL7A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRSILYKRLKVPPAINQFSQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEQKAAGKGDTPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCIIKSKARLGRLVHRKTCTCVAFTQVNPEDKGALAKLVEAVKTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG", "length": 266 }, "evidence": [ { "id": "Q2TBQ5", "url": "https://omabrowser.org/oma/group/Q2TBQ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P46223-1", "protein_name": "Large ribosomal subunit protein eL8", "gene_name": "RpL7A", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVVKKPRPKKKPVTKKVAPAPLAVKKPVVKKVVNQLFEKRPKNFGIGQNVQPKRDLSRFVRWPKYIRVQRQKAVLQKRLKVPPPIHQFSQTLDKTTAVKLFKLLEKYRPESPLAKKLRLKKIAEAKAKGKDVEPKKKPSYVSAGTNTVTKLIEQKKAQLVVIAHDVDPLELVLFLPALCRKMGVPYCIVKGKARLGRLVRRKTCTTLALTTVDNNDKANFGKVLEAVKTNFNERHEEIRRHWGGGILGSKSLARISKLERAKARELAQKQG", "length": 271 }, "evidence": [ { "id": "Q2TBQ5", "url": "https://omabrowser.org/oma/group/Q2TBQ5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P49692-1", "protein_name": "Large ribosomal subunit protein eL8z", "gene_name": "RPL7AA", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAPKKGVKVAAKKKTAEKVSNPLFERRPKQFGIGGALPPKKDLSRYIKWPKSIRLQRQKRILKQRLKVPPALNQFTKTLDKNLATSLFKVLLKYRPEDKAAKKERLVKKAQAEAEGKPSESKKPIVVKYGLNHVTYLIEQNKAQLVVIAHDVDPIELVVWLPALCRKMEVPYCIVKGKSRLGAVVHQKTASCLCLTTVKNEDKLEFSKILEAIKANFNDKYEEYRKKWGGGIMGSKSQAKTKAKERVIAKEAAQRMN", "length": 257 }, "evidence": [ { "id": "Q2TBQ5", "url": "https://omabrowser.org/oma/group/Q2TBQ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P62424-1", "protein_name": "Large ribosomal subunit protein eL8", "gene_name": "RPL7A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCIIKGKARLGRLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG", "length": 266 }, "evidence": [ { "id": "Q2TBQ5", "url": "https://omabrowser.org/oma/group/Q2TBQ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P62425-1", "protein_name": "Large ribosomal subunit protein eL8", "gene_name": "Rpl7a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCIIKGKARLGRLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG", "length": 266 }, "evidence": [ { "id": "Q2TBQ5", "url": "https://omabrowser.org/oma/group/Q2TBQ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q54ZD1-1", "protein_name": "Large ribosomal subunit protein eL8", "gene_name": "rpl7a", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSQKQTKPAAATKAAPAKTAVATTKSKKVVKKGEKKIKTRTLFNALYTKNVKNFGTGFGVQPKRDLTHFTHWPRYIKLQRQRRVLLKRLKVPPTINQFTRVFDKNTAVHLFKLLDKYRPEEASVKKARLLKIAEARAATPKGQAAPKAEKPVQHLRFGIDSVTKLIEKKKAKLVVIAHDVDPVELVLYLPTLCRRMDVPYCIVKSKSRLGELVHMRNASCVALTGVNSADSNELALLVESAKQMFNNNSEHRKTWGGNTLSGPARAILAKRQKAEAKESLAKSKI", "length": 285 }, "evidence": [ { "id": "Q2TBQ5", "url": "https://omabrowser.org/oma/group/Q2TBQ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ5", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ5" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ5", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ5", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ5", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ5" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ5", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ5" } ], "pmid": "" }, { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ5", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ5", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ5" } ], "pmid": "" }, { "name": "maturation of LSU-rRNA", "id": "GO:0000470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000470", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ5", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBQ5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 266, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBQ5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBQ5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2TBQ8-1", "uniprot_ac": "Q2TBQ8", "uniprot_id": "6PGL_BOVIN", "mass": { "chemical_mass": 27547.0, "monoisotopic_mass": 27547.0 }, "refseq": { "ac": "NP_001033669", "name": "6-phosphogluconolactonase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033669" }, "gene_names": [ { "name": "PGLS", "type": "recommended", "evidence": [ { "id": "Q2TBQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ8" } ] }, { "name": "PGLS", "type": "synonym", "evidence": [ { "id": "NP_001033669", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033669" } ] } ], "protein_names": [ { "name": "6-phosphogluconolactonase", "type": "recommended", "evidence": [ { "id": "Q2TBQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ8/entry#names_and_taxonomy" } ] }, { "name": "3.1.1.31", "type": "synonym", "evidence": [ { "id": "Q2TBQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ8/entry#names_and_taxonomy" } ] }, { "name": "6-phosphogluconolactonase", "type": "synonym", "evidence": [ { "id": "NP_001033669", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033669" } ] }, { "name": "6PGL", "type": "synonym", "evidence": [ { "id": "NP_001033669", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033669" }, { "id": "Q2TBQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ8", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ8", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PGLS", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ8", "locus": { "chromosome": "7", "start_pos": 5590621, "end_pos": 5599169, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016783", "url": "https://www.ensembl.org/id/ENSBTAG00000016783" } ] } } ], "crossref": [ { "id": "Q2TBQ8", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBQ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01400", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01400", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616120", "url": "https://www.ncbi.nlm.nih.gov/gene/616120", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005900", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005900", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006148", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006148", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037171", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037171", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039104", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039104", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616120", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616120", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBQ8", "url": "https://www.orthodb.org/?gene=Q2TBQ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11054", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11054", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11054:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11054:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01182", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01182", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033669", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "12556", "url": "https://www.rhea-db.org/rhea/12556", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBQ8", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBQ8-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPAPRLISVFSSPQELGASLAQLVVQQAACCLADAGARFTLGLSGGSLVSMLARELPAAAAPAGPASLARWTLGFCDERLVPFEHAESTYGLYRTHLLSKLPIFDSQVITINPALPVEEAAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGHTCSLFPDHPLLQEREKIVAPISDSPKPPPQRVTLTLPVLNAARTVIYVATGEGKAAILKRILEDKEENPLPAALVQPSAGKLCWFLDEAAARLLTVPFEKHSTL", "length": 258, "header": "sp|Q2TBQ8-1|6PGL_BOVIN Isoform 1 of 6-phosphogluconolactonase OS=Bos taurus OX=9913 GN=PGLS PE=2 SV=1 CANONICAL=Q2TBQ8-1" }, "isoforms": [ { "isoform_ac": "Q2TBQ8-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ8/entry#Q2TBQ8-1", "sequence": { "sequence": "MAAPAPRLISVFSSPQELGASLAQLVVQQAACCLADAGARFTLGLSGGSLVSMLARELPAAAAPAGPASLARWTLGFCDERLVPFEHAESTYGLYRTHLLSKLPIFDSQVITINPALPVEEAAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGHTCSLFPDHPLLQEREKIVAPISDSPKPPPQRVTLTLPVLNAARTVIYVATGEGKAAILKRILEDKEENPLPAALVQPSAGKLCWFLDEAAARLLTVPFEKHSTL", "length": 258, "header": "sp|Q2TBQ8-1|6PGL_BOVIN Isoform 1 of 6-phosphogluconolactonase OS=Bos taurus OX=9913 GN=PGLS PE=2 SV=1 CANONICAL=Q2TBQ8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 49, "end_pos": 49, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ8", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ8" } ], "site_lbl": "Ser49" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:616120", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616120", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ8", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ8", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ8" } ], "pmid": "" }, { "name": "pentose-phosphate shunt, oxidative branch", "id": "GO:0009051", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009051", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ8", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "6-phosphogluconolactonase activity", "id": "GO:0017057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017057", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ8", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12556", "name": "", "equation": "6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MM83-1", "Q2TBQ8-1", "A0A3Q1LRN7-1" ], "evidence": [ { "id": "12556", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12556" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LRN7", "gene_name": "SPSB1", "activity": [ { "ec_number": "3.1.1.31", "activity": "6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+).", "evidence": [ { "id": "A0A3Q1LRN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRN7" } ] }, { "ec_number": "1.1.1.47", "activity": "D-glucose + NAD(+) = D-glucono-1,5-lactone + NADH + H(+).", "evidence": [ { "id": "A0A3Q1LRN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRN7" } ] }, { "ec_number": "1.1.1.363", "activity": "D-glucose 6-phosphate + NAD(+) = 6-phospho-D-glucono-1,5-lactone + NADH + H(+).", "evidence": [ { "id": "A0A3Q1LRN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRN7" } ] }, { "ec_number": "1.1.1.47", "activity": "", "evidence": [ { "id": "A0A3Q1LRN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRN7" } ] }, { "ec_number": "1.1.1.363", "activity": "", "evidence": [ { "id": "A0A3Q1LRN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRN7" } ] }, { "ec_number": "3.1.1.31", "activity": "", "evidence": [ { "id": "A0A3Q1LRN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRN7" } ] } ] }, { "uniprot_ac": "F1MM83", "gene_name": "PGLS", "activity": [ { "ec_number": "3.1.1.31", "activity": "6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+).", "evidence": [ { "id": "F1MM83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM83" } ] }, { "ec_number": "3.1.1.31", "activity": "", "evidence": [ { "id": "F1MM83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM83" } ] } ] }, { "uniprot_ac": "Q2TBQ8", "gene_name": "PGLS", "activity": [ { "ec_number": "3.1.1.31", "activity": "6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+).", "evidence": [ { "id": "Q2TBQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ8" } ] }, { "ec_number": "3.1.1.31", "activity": "", "evidence": [ { "id": "Q2TBQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ8" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBQ8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 258, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBQ8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBQ8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.1.31", "ec_name": "6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+).", "evidence": [ { "id": "3.1.1.31", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.31" }, { "id": "3.1.1.31", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.31" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 49 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBQ9-1", "uniprot_ac": "Q2TBQ9", "uniprot_id": "KLC3_BOVIN", "mass": { "chemical_mass": 55583.0, "monoisotopic_mass": 55583.0 }, "refseq": { "ac": "NP_001033638", "name": "kinesin light chain 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033638" }, "gene_names": [ { "name": "KLC3", "type": "recommended", "evidence": [ { "id": "Q2TBQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ9" } ] }, { "name": "KLC3", "type": "synonym", "evidence": [ { "id": "NP_001033638", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033638" } ] } ], "protein_names": [ { "name": "Kinesin light chain 3", "type": "recommended", "evidence": [ { "id": "Q2TBQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ9/entry#names_and_taxonomy" } ] }, { "name": "kinesin light chain 3", "type": "synonym", "evidence": [ { "id": "NP_001033638", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033638" } ] } ], "function": [ { "annotation": "Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa (By similarity). May play a role in the formation of the mitochondrial sheath formation in the developing spermatid midpiece (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ9#function" }, { "database": "UniProtKB", "id": "Q91W40", "url": "https://www.uniprot.org/uniprotkb/Q91W40#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KLC3", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ9", "locus": { "chromosome": "18", "start_pos": 52982797, "end_pos": 52973914, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002070", "url": "https://www.ensembl.org/id/ENSBTAG00000002070" } ] } } ], "crossref": [ { "id": "Q2TBQ9", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBQ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "517633", "url": "https://www.ncbi.nlm.nih.gov/gene/517633", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002151", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002151", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517633", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517633", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBQ9", "url": "https://www.orthodb.org/?gene=Q2TBQ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45783", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45783", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45783:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45783:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13374", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13374", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13424", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13424", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033638", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033638", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBQ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBQ9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVQVAAPGGLGLGLERPSPEELVRQTRQVVKGLEALRAEHRGLAGHLAEALAAQGPAAGLELLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRAQARRLAQENAWLREELEETQRRLRASEEAVAQLEEEKSHLEFLGQLRQYDPPAESQQPESPPRRDSLASLFPSEEEERRGPEAVGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEEVERHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHREALPAPLGAPNTGTTSDTQQQTLSRSSSFSKLRESIRRGSEKLVSRLRGEGAAGAAGMKRAMSLSMLNTDGSRAPENQFPRQHLSEASRTLSTSTQDLGPR", "length": 505, "header": "sp|Q2TBQ9-1|KLC3_BOVIN Isoform 1 of Kinesin light chain 3 OS=Bos taurus OX=9913 GN=KLC3 PE=2 SV=1 CANONICAL=Q2TBQ9-1" }, "isoforms": [ { "isoform_ac": "Q2TBQ9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ9/entry#Q2TBQ9-1", "sequence": { "sequence": "MSVQVAAPGGLGLGLERPSPEELVRQTRQVVKGLEALRAEHRGLAGHLAEALAAQGPAAGLELLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEKQRLRAQARRLAQENAWLREELEETQRRLRASEEAVAQLEEEKSHLEFLGQLRQYDPPAESQQPESPPRRDSLASLFPSEEEERRGPEAVGAAAAQQGGYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEEVERHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHREALPAPLGAPNTGTTSDTQQQTLSRSSSFSKLRESIRRGSEKLVSRLRGEGAAGAAGMKRAMSLSMLNTDGSRAPENQFPRQHLSEASRTLSTSTQDLGPR", "length": 505, "header": "sp|Q2TBQ9-1|KLC3_BOVIN Isoform 1 of Kinesin light chain 3 OS=Bos taurus OX=9913 GN=KLC3 PE=2 SV=1 CANONICAL=Q2TBQ9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 173, "end_pos": 173, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ9" } ], "site_lbl": "Ser173" }, { "start_pos": 467, "end_pos": 467, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ9" } ], "site_lbl": "Ser467" }, { "start_pos": 499, "end_pos": 499, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ9" } ], "site_lbl": "Thr499" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517633", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517633", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ9" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ9" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ9" } ], "pmid": "" }, { "name": "kinesin complex", "id": "GO:0005871", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005871", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ9", "url": "https://www.uniprot.org/uniprotkb/Q2TBQ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q2TBQ9", 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Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2TBS9", "url": "https://www.uniprot.org/uniprotkb/Q2TBS9#function" }, { "database": "UniProtKB", "id": "Q2TAY7", "url": "https://www.uniprot.org/uniprotkb/Q2TAY7#function" }, { "database": "UniProtKB", "id": "Q76B40", "url": "https://www.uniprot.org/uniprotkb/Q76B40#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBS9", "url": "https://www.uniprot.org/uniprotkb/Q2TBS9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMU1", "url": "https://www.uniprot.org/uniprotkb/Q2TBS9", "locus": { "chromosome": "8", "start_pos": 74805225, "end_pos": 74834388, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019564", "url": "https://www.ensembl.org/id/ENSBTAG00000019564" } ] } } ], "crossref": [ { "id": "Q2TBS9", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBS9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019564", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019564", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540842", "url": "https://www.ncbi.nlm.nih.gov/gene/540842", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006594", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006594", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045184", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045184", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054532", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054532", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540842", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540842", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MMKQQEP", "url": "https://omabrowser.org/oma/group/MMKQQEP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBS9", "url": "https://www.orthodb.org/?gene=Q2TBS9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22848", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22848", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17814", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17814", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23381", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23381", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001033662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033662", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBS9", "url": "https://www.uniprot.org/uniprotkb/Q2TBS9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBS9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBS9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP", "length": 513, "header": "sp|Q2TBS9-1|SMU1_BOVIN Isoform 1 of WD40 repeat-containing protein SMU1 OS=Bos taurus OX=9913 GN=SMU1 PE=2 SV=1 CANONICAL=Q2TBS9-1" }, "isoforms": [ { "isoform_ac": "Q2TBS9-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBS9/entry#Q2TBS9-1", "sequence": { "sequence": "MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP", "length": 513, "header": "sp|Q2TBS9-1|SMU1_BOVIN Isoform 1 of WD40 repeat-containing protein SMU1 OS=Bos taurus OX=9913 GN=SMU1 PE=2 SV=1 CANONICAL=Q2TBS9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540842", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540842", "resource": "KEGG Pathway" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q2TAY7-1", "protein_name": "WD40 repeat-containing protein SMU1", "gene_name": "SMU1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP", "length": 513 }, "evidence": [ { "id": "Q2TBS9", "url": "https://omabrowser.org/oma/group/Q2TBS9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q3UKJ7-1", "protein_name": "WD40 repeat-containing protein SMU1", "gene_name": "Smu1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP", "length": 513 }, "evidence": [ { "id": "Q2TBS9", "url": "https://omabrowser.org/oma/group/Q2TBS9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54Y96-1", "protein_name": "WD40 repeat-containing protein smu1", "gene_name": "smu1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSNPTSTTHHNIEIQSQDVIKLILQFLKENSLGNSLTALQEETGINLNAVDSKETFLNDVKNGNWDSVLTVVSTLRLSTTLLMDLYEQIVELLHLKEYELCKYLIRKTEPLNYMKLNQQERYLKLENHLQREYIDLGDFYKYGITTEKRRKQLIEQLNNEIITVPSSRLLSLLSQSLHWQKHQGIIPDDCMEFDLFKGEVPFKKIESEEEQITTVLDKTIKFNNKNKPETIKFSPDSKYLLTGSMDGFIEVWDYNTGKLSKSLAYQSNDDFMMHDDAILCIAFSKDGEFLATGSLDNKIKVWQIKSGKCLRKFEPAHTNGVTCLQFSRNSTQILSGSFDSSLKIHGLKSGKALKIFRGHQSFVNDCCFNHDEDRVISCSSDGKIKIWDAKSSDCLQTITPTSVVTVRDISIRSITILLKNPEFLLVCNSSQISIVSMKSQTISKTFTSENSKTFLVCTLSPLQNYLYAVDEDNILYTFDFNSGSLLNKFKIHDQEVISISHHPTKNLLATTGSDCLLKIWKSNSNDNINN", "length": 530 }, "evidence": [ { "id": "Q2TBS9", "url": "https://omabrowser.org/oma/group/Q2TBS9/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5ZME8-1", "protein_name": "WD40 repeat-containing protein SMU1", "gene_name": "SMU1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKVWNVKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP", "length": 513 }, "evidence": [ { "id": "Q2TBS9", "url": "https://omabrowser.org/oma/group/Q2TBS9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8W117-1", "protein_name": "Suppressor of mec-8 and unc-52 protein homolog 1", "gene_name": "SMU1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MALEIEARDVIKIMLQFCKENSLNQTFQTLQSECQVSLNTVDSVETFISDINSGRWDSVLPQVSQLKLPRNKLEDLYEQIVLEMIELRELDTARAILRQTQVMGVMKQEQAERYLRMEHLLVRSYFDPHEAYGDSTKERKRAQIAQAVAAEVTVVPPSRLMALIGQALKWQQHQGLLPPGTQFDLFRGTAAMKQDVEDTHPNVLTHTIKFGKKSHAECARFSPDGQFLASSSVDGFIEVWDYISGKLKKDLQYQADESFMMHDDPVLCIDFSRDSEMLASGSQDGKIKIWRIRTGVCIRRFDAHSQGVTSLSFSRDGSQLLSTSFDQTARIHGLKSGKLLKEFRGHTSYVNHAIFTSDGSRIITASSDCTVKVWDSKTTDCLQTFKPPPPLRGTDASVNSIHLFPKNTEHIVVCNKTSSIYIMTLQGQVVKSFSSGNREGGDFVAACVSTKGDWIYCIGEDKKLYCFNYQSGGLEHFMMVHEKDVIGITHHPHRNLLATYSEDCTMKLWKP", "length": 511 }, "evidence": [ { "id": "Q2TBS9", "url": "https://omabrowser.org/oma/group/Q2TBS9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q99M63-1", "protein_name": "WD40 repeat-containing protein SMU1", "gene_name": "Smu1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSIEIESSDVIRLIMQYLKENSLHRALATFTEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP", "length": 513 }, "evidence": [ { "id": "Q2TBS9", "url": "https://omabrowser.org/oma/group/Q2TBS9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9VE18-1", "protein_name": "WD40 repeat-containing protein SMU1", "gene_name": "Smu1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSIEIESADVIRLIQQYLKESNLMKTLQTLQEETGVSLNTVDSVDGFVQDISNGHWDTVLKVTQSLKLPDKKLLNLYEQIVLELIELRELGAARSLLRQTDPMTMLKQQEPERYIHLENMLQRAYFDPREAYAEGSSKEKRRTVIAQELSGEVHVVPSSRLLALLGQALKWQQHQGLLPPGTTIDLFRGKAAMKDQEEEMYPTQLFRQIKFGQKSHVECAQFSPDGQYLITGSVDGFLEVWNFTTGKVRKDLKYQAQDQFMMMEQAVLALNFSRDSEMVASGAQDGQIKVWRIITGQCLRKFEKAHTKGITCLQFSRDNSQVLSASFDYTVRLHGLKSGKMLKEFKGHSSFVNEATFTPDGHSVLSASSDGTVKVWSLKTTECVATYKPLGNELAVNTVLILPKNPEHFIVCNRSNTVVIMNMQGQIVRSFSSGKREGGAFISATLSPRGEFIYCAGEDQVLYCFSVSSGKLERTLNVHEKDVIGLTHHPHQNLLASYSEDGLLKLWKP", "length": 509 }, "evidence": [ { "id": "Q2TBS9", "url": "https://omabrowser.org/oma/group/Q2TBS9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TBS9", "url": "https://www.uniprot.org/uniprotkb/Q2TBS9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2TBS9", "url": "https://www.uniprot.org/uniprotkb/Q2TBS9" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "Q2TBS9", "url": "https://www.uniprot.org/uniprotkb/Q2TBS9" } ], "pmid": "" }, { "name": "precatalytic spliceosome", "id": "GO:0071011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071011", "evidence": [ { "database": "UniProtKB", "id": "Q2TBS9", "url": "https://www.uniprot.org/uniprotkb/Q2TBS9" } ], "pmid": "" }, { "name": "U2-type precatalytic spliceosome", "id": "GO:0071005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071005", "evidence": [ { "database": "UniProtKB", "id": "Q2TBS9", "url": "https://www.uniprot.org/uniprotkb/Q2TBS9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "Q2TBS9", "url": "https://www.uniprot.org/uniprotkb/Q2TBS9" } ], "pmid": "" }, { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "Q2TBS9", "url": "https://www.uniprot.org/uniprotkb/Q2TBS9" } ], "pmid": "" }, { "name": "regulation of alternative mRNA splicing, via spliceosome", "id": "GO:0000381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000381", "evidence": [ { "database": "UniProtKB", "id": "Q2TBS9", "url": "https://www.uniprot.org/uniprotkb/Q2TBS9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 242, "end_pos": 244, "annotation": "n_glycosylation_sequon" }, { "start_pos": 417, "end_pos": 419, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBS9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 513, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBS9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBS9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2TBS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBS9" }, { "id": "PRU00058", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00058" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CTLH", "eco_id": "ECO_0000255", "start_pos": 40, "end_pos": 92, "start_aa": "Thr", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2TBS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBS9" }, { "id": "PRU00126", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00126" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LisH", "eco_id": "ECO_0000255", "start_pos": 6, "end_pos": 38, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 242, "end_pos": 244 }, { "start_pos": 417, "end_pos": 419 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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"total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBV0-1", "uniprot_ac": "Q2TBV0", "uniprot_id": "BEX2_BOVIN", "mass": { "chemical_mass": 15236.0, "monoisotopic_mass": 15236.0 }, "refseq": { "ac": "NP_001070502", "name": "protein BEX2", "summary": "", "url": 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"synonym", "evidence": [ { "id": "Q2TBV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBV0/entry#names_and_taxonomy" } ] }, { "name": "brain expressed, X-linked 1", "type": "synonym", "evidence": [ { "id": "NP_001070502", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070502" } ] }, { "name": "brain-expressed X-linked protein 2 homolog", "type": "synonym", "evidence": [ { "id": "NP_001070502", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070502" } ] }, { "name": "protein BEX2", "type": "synonym", "evidence": [ { "id": "NP_001070502", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070502" } ] } ], "function": [ { "annotation": "Regulator of mitochondrial apoptosis and G1 cell cycle. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV0", "url": "https://www.uniprot.org/uniprotkb/Q2TBV0#function" }, { "database": "UniProtKB", "id": "Q9BXY8", "url": "https://www.uniprot.org/uniprotkb/Q9BXY8#function" }, { "database": "UniProtKB", "id": "Q9WTZ8", "url": "https://www.uniprot.org/uniprotkb/Q9WTZ8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBV0", "url": "https://www.uniprot.org/uniprotkb/Q2TBV0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BEX2", "url": "https://www.uniprot.org/uniprotkb/Q2TBV0", "locus": {} } ], "crossref": [ { "id": "Q2TBV0", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBV0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032875", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032875", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767968", "url": "https://www.ncbi.nlm.nih.gov/gene/767968", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767968", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767968", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GKPQARM", "url": "https://omabrowser.org/oma/group/GKPQARM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBV0", "url": "https://www.orthodb.org/?gene=Q2TBV0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19430", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19430", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19430:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19430:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04538", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04538", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070502", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBV0", "url": "https://www.uniprot.org/uniprotkb/Q2TBV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBV0-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMPKEEQVLKNLTMENANEENEKKDEKEQDANKGEPLALSLGAGEYCVPRGNRRRFRVRQPILHYRWDMTQRLGKPQARMREENIERIGEEMRQLMEKLREKQLSHSLRAVSTDPPHHEHNDEFCLMP", "length": 128, "header": "sp|Q2TBV0-1|BEX2_BOVIN Isoform 1 of Protein BEX2 OS=Bos taurus OX=9913 GN=BEX2 PE=2 SV=1 CANONICAL=Q2TBV0-1" }, "isoforms": [ { "isoform_ac": "Q2TBV0-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV0/entry#Q2TBV0-1", "sequence": { "sequence": "MMPKEEQVLKNLTMENANEENEKKDEKEQDANKGEPLALSLGAGEYCVPRGNRRRFRVRQPILHYRWDMTQRLGKPQARMREENIERIGEEMRQLMEKLREKQLSHSLRAVSTDPPHHEHNDEFCLMP", "length": 128, "header": "sp|Q2TBV0-1|BEX2_BOVIN Isoform 1 of Protein BEX2 OS=Bos taurus OX=9913 GN=BEX2 PE=2 SV=1 CANONICAL=Q2TBV0-1" }, "locus": { "chromosome": "X", "start_pos": 49761961, "end_pos": 49761578, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046677.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046677.5" }, { "database": "Ensembl Peptide", "id": 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"MESKEKRAVNSLSMENANQENEEKEQVANKGEPLALPLDAGEYCVPRGNRRRFRVRQPILQYRWDMMHRLGEPQARMREENMERIGEEVRQLMEKLREKQLSHSLRAVSTDPPHHDHHDEFCLMP", "length": 125 }, "evidence": [ { "id": "Q2TBV0", "url": "https://omabrowser.org/oma/group/Q2TBV0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9R224-1", "protein_name": "Protein BEX1", "gene_name": "Bex1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESKDQGVKNLNMENDHQKKEEKEEKPQDTIRREPAVALTSEAGKNCAPRGGRRRFRVRQPIAHYRWDLMQRVGEPQGRMREENVQRFGGDVRQLMEKLRERQLSHSLRAVSTDPPHHDHHDEFCLMP", "length": 128 }, "evidence": [ { "id": "Q2TBV0", "url": "https://omabrowser.org/oma/group/Q2TBV0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV0", "url": "https://www.uniprot.org/uniprotkb/Q2TBV0" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV0", "url": "https://www.uniprot.org/uniprotkb/Q2TBV0" } ], "pmid": "" }, { "name": "molecular function inhibitor activity", "id": "GO:0140678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140678", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV0", "url": "https://www.uniprot.org/uniprotkb/Q2TBV0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV0", "url": "https://www.uniprot.org/uniprotkb/Q2TBV0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV0", "url": "https://www.uniprot.org/uniprotkb/Q2TBV0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV0", "url": "https://www.uniprot.org/uniprotkb/Q2TBV0" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV0", "url": "https://www.uniprot.org/uniprotkb/Q2TBV0" } ], "pmid": "" }, { "name": "negative regulation of protein ubiquitination", "id": "GO:0031397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031397", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV0", "url": "https://www.uniprot.org/uniprotkb/Q2TBV0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 11, "end_pos": 13, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBV0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 128, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBV0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBV0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q2TBV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBV0#function" }, { "id": "Q2TBV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBV0" } ], "binding_site_uniprot": 125, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "ligand shared with FEM1B", "eco_id": "ECO_0000250", "start_pos": 125, "end_pos": 125, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 11, "end_pos": 13 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBV5-1", "uniprot_ac": "Q2TBV5", "uniprot_id": "TF2H2_BOVIN", "mass": { "chemical_mass": 44512.0, "monoisotopic_mass": 44512.0 }, "refseq": { "ac": "NP_001033619", "name": "general transcription factor IIH subunit 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033619" }, "gene_names": [ { "name": "GTF2H2", "type": "recommended", "evidence": [ { "id": "Q2TBV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBV5" } ] }, { "name": "GTF2H2", "type": "synonym", "evidence": [ { "id": "NP_001033619", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033619" } ] } ], "protein_names": [ { "name": "General transcription factor IIH subunit 2", "type": "recommended", "evidence": [ { "id": "Q2TBV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBV5/entry#names_and_taxonomy" } ] }, { "name": "General transcription factor IIH polypeptide 2", "type": "synonym", "evidence": [ { "id": "Q2TBV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBV5/entry#names_and_taxonomy" } ] }, { "name": "general transcription factor IIH polypeptide 2", "type": "synonym", "evidence": [ { "id": "NP_001033619", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033619" } ] }, { "name": "general transcription factor IIH subunit 2", "type": "synonym", "evidence": [ { "id": "NP_001033619", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033619" } ] } ], "function": [ { "annotation": "Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV5", "url": "https://www.uniprot.org/uniprotkb/Q2TBV5#function" }, { "database": "UniProtKB", "id": "Q13888", "url": "https://www.uniprot.org/uniprotkb/Q13888#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBV5", "url": "https://www.uniprot.org/uniprotkb/Q2TBV5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GTF2H2", "url": "https://www.uniprot.org/uniprotkb/Q2TBV5", "locus": {} } ], "crossref": [ { "id": "Q2TBV5", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBV5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027983", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027983", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01453", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01453", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511829", "url": "https://www.ncbi.nlm.nih.gov/gene/511829", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046349", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046349", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511829", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511829", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2TBV5", "url": "https://www.orthodb.org/?gene=Q2TBV5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12695", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12695", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12695:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12695:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04056", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04056", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07975", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07975", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-113418", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-113418", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5696395", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696395", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5696400", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696400", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-674695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-674695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6781823", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6781823", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6782135", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6782135", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6782210", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6782210", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6796648", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6796648", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72086", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72086", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-73762", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73762", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-73772", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73772", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-73776", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73776", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-73779", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73779", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-73863", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73863", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-75953", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75953", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-75955", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75955", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-76042", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76042", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-77075", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77075", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001033619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033619", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBV5", "url": "https://www.uniprot.org/uniprotkb/Q2TBV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBV5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHITSLKKAVDMTCHGEPSLYNSLSMAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYDLIKSLKAAKIRVSIIGLSAEVRVCTALARETGGTYHVILDESHYKELLTHHVSPPPASSNSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDSNTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEHNGERFCYACQGELKDQHVYVCSVCQNVFCVDCDVFVHDSLHCCPGCIHKIPVPSGI", "length": 395, "header": "sp|Q2TBV5-1|TF2H2_BOVIN Isoform 1 of General transcription factor IIH subunit 2 OS=Bos taurus OX=9913 GN=GTF2H2 PE=2 SV=1 CANONICAL=Q2TBV5-1" }, "isoforms": [ { "isoform_ac": "Q2TBV5-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBV5/entry#Q2TBV5-1", "sequence": { "sequence": "MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHITSLKKAVDMTCHGEPSLYNSLSMAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYDLIKSLKAAKIRVSIIGLSAEVRVCTALARETGGTYHVILDESHYKELLTHHVSPPPASSNSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDSNTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEHNGERFCYACQGELKDQHVYVCSVCQNVFCVDCDVFVHDSLHCCPGCIHKIPVPSGI", "length": 395, "header": "sp|Q2TBV5-1|TF2H2_BOVIN Isoform 1 of General transcription factor IIH subunit 2 OS=Bos taurus OX=9913 GN=GTF2H2 PE=2 SV=1 CANONICAL=Q2TBV5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 95, "end_pos": 95, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV5", "url": "https://www.uniprot.org/uniprotkb/Q2TBV5" } ], "site_lbl": "Tyr95" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511829", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511829", "resource": "KEGG Pathway" }, { "id": "R-BTA-113418", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-113418", "resource": "Reactome", "description": "Formation of the Early Elongation Complex" }, { "id": "R-BTA-5696395", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696395", "resource": "Reactome", "description": "Formation of Incision Complex in GG-NER" }, { "id": "R-BTA-5696400", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696400", "resource": "Reactome", "description": "Dual Incision in GG-NER" }, { "id": "R-BTA-674695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-674695", "resource": "Reactome", "description": "RNA Polymerase II Pre-transcription Events" }, { "id": "R-BTA-6781823", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6781823", "resource": "Reactome", "description": "Formation of TC-NER Pre-Incision Complex" }, { "id": "R-BTA-6782135", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6782135", "resource": "Reactome", "description": "Dual incision in TC-NER" }, { "id": "R-BTA-6782210", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6782210", "resource": "Reactome", "description": "Gap-filling DNA repair synthesis and ligation in TC-NER" }, { "id": "R-BTA-6796648", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6796648", "resource": "Reactome", "description": "TP53 Regulates Transcription of DNA Repair Genes" }, { "id": "R-BTA-72086", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72086", "resource": "Reactome", "description": "mRNA Capping" }, { "id": "R-BTA-73762", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73762", "resource": "Reactome", "description": "RNA Polymerase I Transcription Initiation" }, { "id": "R-BTA-73772", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73772", "resource": "Reactome", "description": "RNA Polymerase I Promoter Escape" }, { "id": "R-BTA-73776", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73776", "resource": "Reactome", "description": "RNA Polymerase II Promoter Escape" }, { "id": "R-BTA-73779", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73779", "resource": "Reactome", "description": "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" }, { "id": "R-BTA-73863", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73863", "resource": "Reactome", "description": "RNA Polymerase I Transcription Termination" }, { "id": "R-BTA-75953", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75953", "resource": "Reactome", "description": "RNA Polymerase II Transcription Initiation" }, { "id": "R-BTA-75955", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75955", "resource": "Reactome", "description": "RNA Polymerase II Transcription Elongation" }, { "id": "R-BTA-76042", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76042", "resource": "Reactome", "description": "RNA Polymerase II Transcription Initiation And Promoter Clearance" }, { "id": "R-BTA-77075", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77075", "resource": "Reactome", "description": "RNA Pol II CTD phosphorylation and interaction with CE" } ], "orthologs": [ { "uniprot_canonical_ac": "E1C9E6-1", "protein_name": "General transcription factor IIH subunit", "gene_name": "GTF2H2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDDEPERTKRWEGGYERTWEILKEDESGSLKATIDDILFKAKRKRIYEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQMGLIVTKSKRAEKMTELSGNPKKHIAALKKAVDMNCQGEPSLYNSLNLAMQTLKHMPGHTSREVLIVFSSLTTCDPANIYDLIKCLKAVKIRVSVIGLSAEVRVCTVLTRETGGTYHVILDETHYKELLMHHVSPPPASSTSECSLIRMGFPQHTTASLSDQDAKPSFSMAQLENNSEPCLTLDGYFCPQCRAKYSELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYQGERYCQGCQAEIKDQNVYICKTCKNAFCVECDVFVHDSLHCCPGCIHEQPAPTSV", "length": 395 }, "evidence": [ { "id": "Q2TBV5", "url": "https://omabrowser.org/oma/group/Q2TBV5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q04673-1", "protein_name": "General transcription and DNA repair factor IIH subunit SSL1", "gene_name": "SSL1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAPVVISESEEDEDRVAITRRTKRQVHFDGEGDDRVDQQQQQHSSSHRDRDKHVQRKKKKRLSNRNLQGSNGGYAWEDEIKRSWDLVKVDDEGDMASLVASIVEARKKRTAKKNITPYQRGIIRSLILTLDCSEAMLEKDLRPNRHAMIIQYAIDFVHEFFDQNPISQMGIIIMRNGLAQLVSQVSGNPQDHIDALKSIRKQEPKGNPSLQNALEMARGLLLPVPAHCTREVLIVFGSLSTTDPGDIHQTIDSLVSEKIRVKVLGLSAQVAICKELCKATNYGDESFYKILLDETHLKELFNEAVTPLPVNKINKGFTLVKMGFPTRIFEDTPTFCSCHSKLVYGGYFCPNCHSKVCSLPTVCPCCDLMLILSTHLARSYHHLMPLKTFAEVPTTEKFRSEDCFSCQSRFPILKNHKNGKLLTSSRYRCEDCKQEFCVDCDVFIHEILHNCPGCESKPVIT", "length": 461 }, "evidence": [ { "id": "Q2TBV5", "url": "https://omabrowser.org/oma/group/Q2TBV5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q13888-1", "protein_name": "General transcription factor IIH subunit 2", "gene_name": "GTF2H2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHITSLKKAVDMTCHGEPSLYNSLSIAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDESHYKELLTHHVSPPPASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDGNTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYNGERFCYGCQGELKDQHVYVCAVCQNVFCVDCDVFVHDSLHCCPGCIHKIPAPSGV", "length": 395 }, "evidence": [ { "id": "Q2TBV5", "url": "https://omabrowser.org/oma/group/Q2TBV5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q86KZ2-1", "protein_name": "General transcription factor IIH subunit 2", "gene_name": "gtf2h2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSKNIYNNNAQNKRTNRSLYDDEDGPAHVLQTNDEDGTNKYKWENRFEKTWLTIDEDEHGLRPSNQEERNTRNRRLKNKDRDGILSQDQRVRRGMQRHLCLILDLSKTLSNQDLKPSRYQVLLQNVELFIKEFFDQNPISQLSIIITKNSKAEKISELSGNRLRHIQAMKDAIAMEGEPSIQNSLEVALSSLCYVPKYGSREVLFIFSSLTTCDPSSLQKTIQSLKNESIRVSFIHMAAELYICKAIAEQTNGTSKVILNEEHFNESLMLKCQPPPTIGKTEAALVEMGFPQQITSTVPSPCICHEKMKYSGYICPRCGVKSCELPTDCQICNLSLVSSPHLARSYHHLFQIPLFNEVNWKELNKNVTCIGCLSSSEKSILSLFFSCPRCQEIFCLDCDLFIHESLHNCPGCENKLQNTNTNTNGKTNGNEITNGNGNGNGNENENGNGNGNGNGNGNGLH", "length": 461 }, "evidence": [ { "id": "Q2TBV5", "url": "https://omabrowser.org/oma/group/Q2TBV5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9VNP8-1", "protein_name": "General transcription factor IIH subunit", "gene_name": "Ssl1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MADDEQEDQKEYRWETGYEKTWEAIKDDEDGMLDGAIAEIIQKAKRQRQAQKSKQNRLGMMRHMFVVLDCSESMSVPDLKPTRLRCTVKLLELFIEEFFDQNPISQLGLIALKAKRAEKVTELTGTSRVHLKALESLANVSLTSEPSLQNGLDLALKSLKVVPSHASREIVIIMGSLTTCDPVDINLTIDELKKEGIRCSVISLSAEIHVARYLTQQTMGTFGAVLDDAHFRDQLMSQVDPPPAAKTQHNSLIRMGFPHTKNEVEGKDAPLSMCMCHIENLEEPSELTTTGHHCPQCNSKYCELPVECQSCGLTLVSAPHLARSYHHLFPVPNFEELPFEAMPASSSDLTSDVRECYGCAKALGQGVDKVADKVVFRCGFCKQFFCVDCDIFIHDTLHACVGCNTIPGVDGLVYQQSSKSDQVDAHPGPSKQRGQCGM", "length": 438 }, "evidence": [ { "id": "Q2TBV5", "url": "https://omabrowser.org/oma/group/Q2TBV5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9ZVN9-1", "protein_name": "General transcription factor IIH subunit 2", "gene_name": "GTF2H2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSNQRKRSNDEREEEDDEDAEGIGEWERAYVDDRSWEELQEDESGLLRPIDNSAIYHAQYRRRLRMLSAAAAGTRIQKGLIRYLYIVIDFSRAAAEMDFRPSRMAIMAKHVEAFIREFFDQNPLSQIGLVSIKNGVAHTLTDLGGSPETHIKALMGKLEALGDSSLQNALELVHEHLNQVPSYGHREVLILYSALCTCDPGDIMETIQKCKKSKLRCSVIGLSAEMFICKHLCQETGGLYSVAVDEVHLKDLLLEHAPPPPAIAEFAIANLIKMGFPQRAAEGSMAICSCHKEVKIGAGYMCPRCKARVCDLPTECTICGLTLVSSPHLARSYHHLFPIAPFDEVPALSSLNDNRRKLGKSCFGCQQSLIGAGNKPVPCVTCRKCKHYFCLDCDIYIHESLHNCPGCESIHRPKSVSLMEE", "length": 421 }, "evidence": [ { "id": "Q2TBV5", "url": "https://omabrowser.org/oma/group/Q2TBV5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV5", "url": "https://www.uniprot.org/uniprotkb/Q2TBV5" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV5", "url": "https://www.uniprot.org/uniprotkb/Q2TBV5" } ], "pmid": "" }, { "name": "transcription factor TFIIH holo complex", "id": "GO:0005675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005675", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV5", "url": "https://www.uniprot.org/uniprotkb/Q2TBV5" } ], "pmid": "" }, { "name": "core TFIIH complex portion of holo TFIIH complex", "id": "GO:0000438", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000438", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV5", "url": "https://www.uniprot.org/uniprotkb/Q2TBV5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV5", "url": "https://www.uniprot.org/uniprotkb/Q2TBV5" } ], "pmid": "" }, { "name": "transcription by RNA polymerase II", "id": "GO:0006366", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV5", "url": "https://www.uniprot.org/uniprotkb/Q2TBV5" } ], "pmid": "" }, { "name": "nucleotide-excision repair", "id": "GO:0006289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006289", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV5", "url": "https://www.uniprot.org/uniprotkb/Q2TBV5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q2TBV5", "url": "https://www.uniprot.org/uniprotkb/Q2TBV5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], 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May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons (By similarity). 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[], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2TBW0", "url": "https://www.uniprot.org/uniprotkb/Q2TBW0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2TBW0", "url": "https://www.uniprot.org/uniprotkb/Q2TBW0" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "Q2TBW0", "url": "https://www.uniprot.org/uniprotkb/Q2TBW0" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "Q2TBW0", "url": "https://www.uniprot.org/uniprotkb/Q2TBW0" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "Q2TBW0", "url": "https://www.uniprot.org/uniprotkb/Q2TBW0" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "Q2TBW0", "url": "https://www.uniprot.org/uniprotkb/Q2TBW0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "neuron projection development", "id": "GO:0031175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031175", "evidence": [ { "database": "UniProtKB", "id": "Q2TBW0", "url": "https://www.uniprot.org/uniprotkb/Q2TBW0" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q2TBW0", "url": "https://www.uniprot.org/uniprotkb/Q2TBW0" } ], 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBW8-1", "uniprot_ac": "Q2TBW8", "uniprot_id": "RL10L_BOVIN", "mass": { "chemical_mass": 24586.0, "monoisotopic_mass": 24586.0 }, "refseq": { "ac": "NP_001192330", "name": "large ribosomal subunit protein uL16-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192330" }, "gene_names": [ { "name": "RPL10L", "type": "recommended", "evidence": [ { "id": "Q2TBW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW8" } ] }, { "name": "RPL10L", "type": "synonym", "evidence": [ { "id": "NP_001192330", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192330" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein uL16-like", "type": "recommended", "evidence": [ { "id": "Q2TBW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW8/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L10-like", "type": "synonym", "evidence": [ { "id": "NP_001192330", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192330" }, { "id": "Q2TBW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBW8/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein uL16-like", "type": "synonym", "evidence": [ { "id": "NP_001192330", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192330" } ] } ], "function": [ { "annotation": "Testis-specific component of the ribosome, which is required for the transition from prophase to metaphase in male meiosis I (By similarity). Compensates for the inactivated X-linked RPL10 paralog during spermatogenesis. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2TBW8", "url": "https://www.uniprot.org/uniprotkb/Q2TBW8#function" }, { "database": "UniProtKB", "id": "Q96L21", "url": "https://www.uniprot.org/uniprotkb/Q96L21#function" }, { "database": "UniProtKB", "id": "P86048", "url": "https://www.uniprot.org/uniprotkb/P86048#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBW8", "url": "https://www.uniprot.org/uniprotkb/Q2TBW8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL10L", "url": "https://www.uniprot.org/uniprotkb/Q2TBW8", "locus": { "chromosome": "10", "start_pos": 39647709, "end_pos": 39648473, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024582", "url": "https://www.ensembl.org/id/ENSBTAG00000024582" } ] } } ], "crossref": [ { "id": "Q2TBW8", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBW8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024582", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024582", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01433", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01433", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538748", "url": "https://www.ncbi.nlm.nih.gov/gene/538748", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001197", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016180", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016180", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018255", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018255", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036920", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036920", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538748", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538748", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GNHEIYR", "url": "https://omabrowser.org/oma/group/GNHEIYR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBW8", "url": "https://www.orthodb.org/?gene=Q2TBW8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11726", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11726", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00252", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00252", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192330", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBW8", "url": "https://www.uniprot.org/uniprotkb/Q2TBW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBW8-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBW8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADEFEDKVAKKRLIPDGCGVKYVPNRGPLDKWRALHS", "length": 214, "header": "sp|Q2TBW8-1|RL10L_BOVIN Isoform 1 of Large ribosomal subunit protein uL16-like OS=Bos taurus OX=9913 GN=RPL10L PE=2 SV=1 CANONICAL=Q2TBW8-1" }, "isoforms": [ { "isoform_ac": "Q2TBW8-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBW8/entry#Q2TBW8-1", "sequence": { "sequence": "MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADEFEDKVAKKRLIPDGCGVKYVPNRGPLDKWRALHS", "length": 214, "header": "sp|Q2TBW8-1|RL10L_BOVIN Isoform 1 of Large ribosomal subunit protein uL16-like OS=Bos taurus OX=9913 GN=RPL10L PE=2 SV=1 CANONICAL=Q2TBW8-1" }, "locus": { "chromosome": "10", "start_pos": 39648426, "end_pos": 39647785, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007086.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007086.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007086.4", "url": "https://www.ensembl.org/id/ENSBTAP00000007086.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538748", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538748", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "P86048-1", "protein_name": "Large ribosomal subunit protein uL16-like", "gene_name": "Rpl10l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADEFEDKVAAKRLIPDGCGVKYIPERGPLDKWRALHS", "length": 214 }, "evidence": [ { "id": "Q2TBW8", "url": "https://omabrowser.org/oma/group/Q2TBW8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7ZV96-1", "protein_name": "Large ribosomal subunit protein uL16", "gene_name": "rpl10", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGRRPARCYRYCKNKPYPKSRFCRGVPDPKIRIFDLGRKKAKVDEFPLCAHMVSDEYEQLSSEALEAARICANKYMVKTCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSVRTKAQNKEHVIEALRRAKFKFPGRQKIHVSKKYGFTKFNTCDFDNMLAEKRLIPDGCGVKYIPSRGPLSRWKALHAN", "length": 215 }, "evidence": [ { "id": "Q2TBW8", "url": "https://omabrowser.org/oma/group/Q2TBW8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q93VT9-1", "protein_name": "Large ribosomal subunit protein uL16z", "gene_name": "RPL10A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGRRPARCYRQIKGKPYPKSRYCRGVPDPKIRIYDVGMKRKGVDEFPFCVHLVSWEKENVSSEALEAARIACNKYMVKSAGKDAFHLRIRVHPFHVLRINKMLSCAGADRLQTGMRGAFGKALGTCARVAIGQVLLSVRCKDAHGHHAQEALRRAKFKFPGRQKIIVSRKWGFTKFNRADFTKLRQEKRVVPDGVNAKFLSCHGPLANRQPGSAFLPAHY", "length": 220 }, "evidence": [ { "id": "Q2TBW8", "url": "https://omabrowser.org/oma/group/Q2TBW8/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TBW8", "url": "https://www.uniprot.org/uniprotkb/Q2TBW8" } ], "pmid": "" }, { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "Q2TBW8", "url": "https://www.uniprot.org/uniprotkb/Q2TBW8" } ], "pmid": "" }, { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q2TBW8", "url": "https://www.uniprot.org/uniprotkb/Q2TBW8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": 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], "sequence": { "sequence": "MAASKDGCGVGEVAAGNGRRLHLGIPEAVFVEDVDSFMKQPGNETADIVLKKLDEQYQKYKFMELNLAQKKRRLKGQIPEIKQTLEILKYKQKKKESTSSLETRFLLADNLYCKASVPPTDKVCLWLGANVMLEYDIDEAQALLEKNLLTATKNLDSLEEDLDFLRDQFTTTEVNMARVYNWDVKRRNKDDSTKNKA", "length": 197, "header": "sp|Q2TBX2-1|PFD3_BOVIN Isoform 1 of Prefoldin subunit 3 OS=Bos taurus OX=9913 GN=VBP1 PE=2 SV=1 CANONICAL=Q2TBX2-1" }, "isoforms": [ { "isoform_ac": "Q2TBX2-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBX2/entry#Q2TBX2-1", "sequence": { "sequence": "MAASKDGCGVGEVAAGNGRRLHLGIPEAVFVEDVDSFMKQPGNETADIVLKKLDEQYQKYKFMELNLAQKKRRLKGQIPEIKQTLEILKYKQKKKESTSSLETRFLLADNLYCKASVPPTDKVCLWLGANVMLEYDIDEAQALLEKNLLTATKNLDSLEEDLDFLRDQFTTTEVNMARVYNWDVKRRNKDDSTKNKA", "length": 197, "header": "sp|Q2TBX2-1|PFD3_BOVIN Isoform 1 of Prefoldin subunit 3 OS=Bos taurus OX=9913 GN=VBP1 PE=2 SV=1 CANONICAL=Q2TBX2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": 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"go_terms": [ { "name": "tubulin binding", "id": "GO:0015631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015631", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX2", "url": "https://www.uniprot.org/uniprotkb/Q2TBX2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBX2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 197, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBX2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBX2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 43, "end_pos": 45 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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{ "database": "UniProtKB", "id": "Q2TBX4", "url": "https://www.uniprot.org/uniprotkb/Q2TBX4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBX4", "url": "https://www.uniprot.org/uniprotkb/Q2TBX4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HSPA13", "url": "https://www.uniprot.org/uniprotkb/Q2TBX4", "locus": { "chromosome": "1", "start_pos": 22794051, "end_pos": 22783919, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012908", "url": "https://www.ensembl.org/id/ENSBTAG00000012908" } ] } } ], "crossref": [ { "id": "Q2TBX4", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBX4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012908", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012908", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10237", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10237", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505907", "url": "https://www.ncbi.nlm.nih.gov/gene/505907", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505907", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505907", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GGMFITR", "url": "https://omabrowser.org/oma/group/GGMFITR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2TBX4", "url": "https://www.orthodb.org/?gene=Q2TBX4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19375", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19375", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00012", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00012", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PR:Q2TBX4", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:Q2TBX4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-BTA-3371453", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371453", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001033594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033594", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2TBX4", "url": "https://www.uniprot.org/uniprotkb/Q2TBX4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2TBX4-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBX4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGEMTILGSAVLTLLLAGYLAQQYLPLPTPKVIGIDLGTTYCSVGVFFPGTGKVKVIPDENGHISIPSMVSFTDDDVYVGYESLELADSNPQNTIYDAKRFIGKVFTPEELEAEIGRYPFKVLNKNGMVEFSVTSNETITVSPEYVGSRLLLKLKEMAEEYLGMPVANAVISVPAEFDLKQRNSTIQAANLAGLKILRVINEPTAAAMAYGLHKAEVFHVLVIDLGGGTLDVSLLNKQGGMFLTRAMSGNNKLGGQDFNQRLLQYLYKQIYQTYGFLPSRKEEIHRLRQAVEMVKLNLTLHETAQMSVLLTVEENDRKGPPTSDSELPKDKFSQANDPHVDSMFGANLSEKKNGEGQVLFETEISRKLFDTLNEDLFQKILVPIQQVLKEGHLEKTEIDEVVLVGGSTRIPRIRQVIQEFFGKDPNTSVDPDLAVVTGVAIQAGIDGGSWPLQVSALEIPNKHLQKTNFN", "length": 471, "header": "sp|Q2TBX4-1|HSP13_BOVIN Isoform 1 of Heat shock 70 kDa protein 13 OS=Bos taurus OX=9913 GN=HSPA13 PE=2 SV=1 CANONICAL=Q2TBX4-1" }, "isoforms": [ { "isoform_ac": "Q2TBX4-1", "url": "https://www.uniprot.org/uniprotkb/Q2TBX4/entry#Q2TBX4-1", "sequence": { "sequence": "MAGEMTILGSAVLTLLLAGYLAQQYLPLPTPKVIGIDLGTTYCSVGVFFPGTGKVKVIPDENGHISIPSMVSFTDDDVYVGYESLELADSNPQNTIYDAKRFIGKVFTPEELEAEIGRYPFKVLNKNGMVEFSVTSNETITVSPEYVGSRLLLKLKEMAEEYLGMPVANAVISVPAEFDLKQRNSTIQAANLAGLKILRVINEPTAAAMAYGLHKAEVFHVLVIDLGGGTLDVSLLNKQGGMFLTRAMSGNNKLGGQDFNQRLLQYLYKQIYQTYGFLPSRKEEIHRLRQAVEMVKLNLTLHETAQMSVLLTVEENDRKGPPTSDSELPKDKFSQANDPHVDSMFGANLSEKKNGEGQVLFETEISRKLFDTLNEDLFQKILVPIQQVLKEGHLEKTEIDEVVLVGGSTRIPRIRQVIQEFFGKDPNTSVDPDLAVVTGVAIQAGIDGGSWPLQVSALEIPNKHLQKTNFN", "length": 471, "header": "sp|Q2TBX4-1|HSP13_BOVIN Isoform 1 of Heat shock 70 kDa protein 13 OS=Bos taurus OX=9913 GN=HSPA13 PE=2 SV=1 CANONICAL=Q2TBX4-1" }, "locus": { "chromosome": "1", "start_pos": 22793409, "end_pos": 22783952, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000139161.1", "url": "https://www.ensembl.org/id/ENSBTAT00000139161.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107431.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107431.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505907", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505907", "resource": "KEGG Pathway" }, { "id": "R-BTA-3371453", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371453", "resource": "Reactome", "description": "Regulation of HSF1-mediated heat shock response" } ], "orthologs": [ { "uniprot_canonical_ac": "O35162-1", "protein_name": "Heat shock 70 kDa protein 13", "gene_name": "Hspa13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGEMTILGSAVLTLLLAGYLAQQYLPLPTPKVIGIDLGTTYCSVGVFFPGTGKVKVIPDENGHISIPSMVSFTDGDVYVGYESLELADSNPQNTIYDAKRFIGKIFTPEELEAEIGRYPFKVLHKNGMAEFSVTSNETIIVSPEYVGSRLLLKLKEMAEKYLGMPVANAVISVPAEFDLQQRNSTIQAANLAGLKILRVINEPTAAAMAYGLHKVDVFYVLVIDLGGGTLDVSLLNKQGGMFLTRAMSGNNKLGGQDFNQRLLQYLYKEIYQTYGFLPSRKEEIHRLRQAVEMVKLNLTLHQSAQVSVLLTVEENDSQKPQNADSKLPEDQLTPGDGHHVNRVFRPGLSDSTSGKSQVLFETEVSRKLFNTLNEDLFQKILVPIQQVLKEGLLDKTEIDEVVLVGGSTRIPRIRQVIQEFFGKDPNTSVDPDLAVVTGVAIQAGIDGGSWPLQVSALEIPNKHLQKTNFN", "length": 471 }, "evidence": [ { "id": "Q2TBX4", "url": "https://omabrowser.org/oma/group/Q2TBX4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P48723-1", "protein_name": "Heat shock 70 kDa protein 13", "gene_name": "HSPA13", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAREMTILGSAVLTLLLAGYLAQQYLPLPTPKVIGIDLGTTYCSVGVFFPGTGKVKVIPDENGHISIPSMVSFTDNDVYVGYESVELADSNPQNTIYDAKRFIGKIFTAEELEAEIGRYPFKVLNKNGMVEFSVTSNETITVSPEYVGSRLLLKLKEMAEAYLGMPVANAVISVPAEFDLKQRNSTIEAANLAGLKILRVINEPTAAAMAYGLHKADVFHVLVIDLGGGTLDVSLLNKQGGMFLTRAMSGNNKLGGQDFNQRLLQYLYKQIYQTYGFVPSRKEEIHRLRQAVEMVKLNLTLHQSAQLSVLLTVEEQDRKEPHSSDTELPKDKLSSADDHRVNSGFGRGLSDKKSGESQVLFETEISRKLFDTLNEDLFQKILVPIQQVLKEGHLEKTEIDEVVLVGGSTRIPRIRQVIQEFFGKDPNTSVDPDLAVVTGVAIQAGIDGGSWPLQVSALEIPNKHLQKTNFN", "length": 471 }, "evidence": [ { "id": "Q2TBX4", "url": "https://omabrowser.org/oma/group/Q2TBX4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BM72-1", "protein_name": "Heat shock 70 kDa protein 13", "gene_name": "Hspa13", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGEMTILGSAVLTLLLAGYLAQQYLPLPTPKVIGIDLGTTYCSVGVFFPGTGKVKVIPDENGHISIPSMVSFTDGDVYVGYESLELADSNPQNTIYDAKRFIGKIFTPEELEAEVGRYPFKVLHRNGMAEFSVTSNETIIVSPEFVGSRLLLKLKEMAEEYLGMPVANAVISVPAEFDLQQRNSTIQAANLAGLKILRVINEPTAAAMAYGLHKVDVFYVLVIDLGGGTLDVSLLNKQGGMFLTRAMSGNNKLGGQDFNQRLLQHLYKEIYQTYGFLPSRKEEIHRLRQAVEMVKLNLTIHQSAQVSVLLTVEGKDSKEPQNGDSELPKDQLTPGDGHHVNRVFRPGLSESKSGKSQVLFETEVSRKLFDALNEDLFQKILVPIQQVLKEGLLDKTEIDEVVLVGGSTRIPRIRQVIQEFFGKDPNTSVDPDLAVVTGVAIQAGIDGGSWPLQVSALEIPNKHLQKTNFN", "length": 471 }, "evidence": [ { "id": "Q2TBX4", "url": "https://omabrowser.org/oma/group/Q2TBX4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX4", "url": "https://www.uniprot.org/uniprotkb/Q2TBX4" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX4", "url": "https://www.uniprot.org/uniprotkb/Q2TBX4" } ], "pmid": "" }, { "name": "heat shock protein binding", "id": "GO:0031072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031072", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX4", "url": "https://www.uniprot.org/uniprotkb/Q2TBX4" } ], "pmid": "" }, { "name": "protein folding chaperone", "id": "GO:0044183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044183", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX4", "url": "https://www.uniprot.org/uniprotkb/Q2TBX4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX4", "url": "https://www.uniprot.org/uniprotkb/Q2TBX4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX4", "url": "https://www.uniprot.org/uniprotkb/Q2TBX4" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX4", "url": "https://www.uniprot.org/uniprotkb/Q2TBX4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX4", "url": "https://www.uniprot.org/uniprotkb/Q2TBX4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX4", "url": "https://www.uniprot.org/uniprotkb/Q2TBX4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein refolding", "id": "GO:0042026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042026", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX4", "url": "https://www.uniprot.org/uniprotkb/Q2TBX4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" }, { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" }, { "start_pos": 348, "end_pos": 350, "annotation": "n_glycosylation_sequon" }, { "start_pos": 427, "end_pos": 429, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBX4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 471, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBX4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBX4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 137, "end_pos": 139 }, { "start_pos": 184, "end_pos": 186 }, { "start_pos": 298, "end_pos": 300 }, { "start_pos": 348, "end_pos": 350 }, { "start_pos": 427, "end_pos": 429 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2TBX6-1", "uniprot_ac": "Q2TBX6", "uniprot_id": "PSB1_BOVIN", "mass": { "chemical_mass": 26246.0, "monoisotopic_mass": 26246.0 }, "refseq": { "ac": "NP_001033628", "name": "proteasome subunit beta type-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033628" }, "gene_names": [ { "name": "PSMB1", "type": "recommended", "evidence": [ { "id": "Q2TBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBX6" } ] }, { "name": "PSMB1", "type": "synonym", "evidence": [ { "id": "NP_001033628", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033628" } ] } ], "protein_names": [ { "name": "Proteasome subunit beta type-1", "type": "recommended", "evidence": [ { "id": "Q2TBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBX6/entry#names_and_taxonomy" } ] }, { "name": "proteasome (prosome, macropain) subunit, beta type, 1", "type": "synonym", "evidence": [ { "id": "NP_001033628", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033628" } ] }, { "name": "proteasome beta 1 subunit", "type": "synonym", "evidence": [ { "id": "NP_001033628", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033628" } ] }, { "name": "proteasome subunit beta 1", "type": "synonym", "evidence": [ { "id": "NP_001033628", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033628" } ] }, { "name": "proteasome subunit beta type-1", "type": "synonym", "evidence": [ { "id": "NP_001033628", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033628" } ] } ], "function": [ { "annotation": "Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX6", "url": "https://www.uniprot.org/uniprotkb/Q2TBX6#function" }, { "database": "UniProtKB", "id": "P20618", "url": "https://www.uniprot.org/uniprotkb/P20618#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2TBX6", "url": "https://www.uniprot.org/uniprotkb/Q2TBX6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSMB1", "url": "https://www.uniprot.org/uniprotkb/Q2TBX6", "locus": { "chromosome": "9", "start_pos": 104070553, "end_pos": 104088414, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007685", "url": "https://www.ensembl.org/id/ENSBTAG00000007685" } ] } } ], "crossref": [ { "id": "Q2TBX6", "url": "https://alphafold.ebi.ac.uk/entry/Q2TBX6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03757", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03757", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514237", "url": "https://www.ncbi.nlm.nih.gov/gene/514237", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "1IRU", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=1IRU&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "7DR6", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=7DR6&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "7DR7", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=7DR7&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "7DRW", "url": 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"MLSSVAAYSGAGRDLAMEPHSSVGPLQLRFSPYAFNGGTVLAIAGEDFSIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALKVCIVTKEGIRGETVPLRKD", "length": 241, "header": "sp|Q2TBX6-1|PSB1_BOVIN Isoform 1 of Proteasome subunit beta type-1 OS=Bos taurus OX=9913 GN=PSMB1 PE=1 SV=1 CANONICAL=Q2TBX6-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "S", "relation": "attached", "comment": "O-linked (GlcNAc) serine;O-GlcNAcylation", "icn3d_view": {}, "start_pos": 209, "start_aa": "Ser", "end_pos": 209, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser209", "evidence": [ { "id": "Q2TBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBX6#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "S", "relation": "attached", "comment": "O-linked (GlcNAc) serine;O-GlcNAcylation", "icn3d_view": {}, "start_pos": 58, "start_aa": "Ser", "end_pos": 58, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser58", "evidence": [ { "id": "Q2TBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBX6#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 150, "end_pos": 150, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX6", "url": "https://www.uniprot.org/uniprotkb/Q2TBX6" } ], "site_lbl": "Tyr150" }, { "start_pos": 162, "end_pos": 162, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX6", "url": "https://www.uniprot.org/uniprotkb/Q2TBX6" } ], "site_lbl": "Ser162" }, { "start_pos": 62, "end_pos": 62, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX6", "url": "https://www.uniprot.org/uniprotkb/Q2TBX6" } ], "site_lbl": "Ser62" }, { "start_pos": 68, "end_pos": 68, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2TBX6", "url": "https://www.uniprot.org/uniprotkb/Q2TBX6" } ], "site_lbl": "Ser68" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The structure of the mammalian 20S proteasome at 2.75 A resolution.", "journal": "Structure", "date": "2002", "authors": "Unno Masaki, Mizushima Tsunehiro, Morimoto Yukio, Tomisugi Yoshikazu, Tanaka Keiji, Yasuoka Noritake, Tsukihara Tomitake", "evidence": [ { 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"site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2TBX6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 241, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2TBX6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2TBX6" }, { "pdb_id": "1iru", "pdb_chain": "1/m", "start_pos": 29, "end_pos": 241, "overlap": "0.88", "method": "X-Ray_Crystallography", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/1iru.pdb", "url_external": "https://www.rcsb.org/structure/1iru" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 58, 209 ], "snv_sites": [], 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"count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"CEP43", "type": "recommended", "evidence": [ { "id": "Q2YDD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDD1" } ] }, { "name": "CEP43", "type": "synonym", "evidence": [ { "id": "NP_001071327", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071327" } ] }, { "name": "FGFR1OP", "type": "synonym", "evidence": [ { "id": "NP_001071327", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071327" }, { "id": "Q2YDD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDD1" } ] } ], "protein_names": [ { "name": "Centrosomal protein 43", "type": "recommended", "evidence": [ { "id": "Q2YDD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDD1/entry#names_and_taxonomy" } ] }, { "name": "FGFR1 oncogene partner 1", "type": "synonym", "evidence": [ { "id": "NP_001071327", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071327" } ] }, { "name": "FGFR1 oncogene 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"MAATAAAVVAEEDTELRYLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFTLAVFQPETSTFQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKALTSGEGALDLSDVHSPPKSPEGKTGAHTPPSKIPRYKGQGNKKTSGQQPGAKKASNDASHSDTSISSSEPKSRSGLHLLAHETKIGSLLSNNSLDVNAKAGPGPEEDDLEGDSFFDDPIPKPEAAYGWRSEPSKQAGSLASLSDAPPLKSGLSSLAGAPSLKESESKRGNTVLKDLKLVNDKIGSLGLGTGEEDDYVDDFNSTSHRSEKSELSIGEEIEEDLSVEMDDVNTSDKLDDLTQDLTVSQLSDVADYLEDVA", "length": 399, "header": "sp|Q2YDD1-1|CEP43_BOVIN Isoform 1 of Centrosomal protein 43 OS=Bos taurus OX=9913 GN=CEP43 PE=2 SV=1 CANONICAL=Q2YDD1-1" }, "isoforms": [ { "isoform_ac": "Q2YDD1-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDD1/entry#Q2YDD1-1", "sequence": { "sequence": 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"site_lbl": "Ser2" }, { "start_pos": 32, "end_pos": 32, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2YDD2", "url": "https://www.uniprot.org/uniprotkb/Q2YDD2" } ], "site_lbl": "Ser32" }, { "start_pos": 451, "end_pos": 451, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2YDD2", "url": "https://www.uniprot.org/uniprotkb/Q2YDD2" } ], "site_lbl": "Ser451" }, { "start_pos": 4, "end_pos": 4, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2YDD2", "url": "https://www.uniprot.org/uniprotkb/Q2YDD2" } ], "site_lbl": "Ser4" }, { "start_pos": 53, "end_pos": 53, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { 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"kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE4", "url": "https://www.uniprot.org/uniprotkb/Q2YDE4" } ], "site_lbl": "Ser64" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The structure of the mammalian 20S proteasome at 2.75 A resolution.", "journal": "Structure", "date": "2002", "authors": "Unno Masaki, Mizushima Tsunehiro, Morimoto Yukio, Tomisugi Yoshikazu, Tanaka Keiji, Yasuoka Noritake, Tsukihara Tomitake", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE4", "url": "https://www.uniprot.org/uniprotkb/Q2YDE4" } ], "reference": [ { "type": "PubMed", "id": "12015144", "url": "https://glygen.org/publication/PubMed/12015144" } ] } ], "pathway": [ { "id": "bta:507213", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507213", "resource": "KEGG Pathway" }, { "id": "R-BTA-1169091", "name": "", "url": 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"MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD", "length": 246 }, "evidence": [ { "id": "Q2YDE4", "url": "https://omabrowser.org/oma/group/Q2YDE4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q54XM7-1", "protein_name": "Proteasome subunit alpha type-6", "gene_name": "psmA6", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSRSGTAGYDMSIIFSPQGKLYQIEYAFKAIKTGGLTSVGIRGKDCVVVATQKKIPDKLIDPKSVTSLYKLTDYIGCVQTGIVPDSKSQASRAIQECATFHHKFGYQIPPNVLAKRMADIAQLSTQHASARPLGVAMILIGIDDELGPQLFKVDPAGVFTGYKATAAGEKEQESTNFLEKKFKSNPQLSKDETIQVSLIVMAISTLQSVLGADLKSSDLEIGICTMDNRKFVIMTDEDIDSQLTKLAERD", "length": 250 }, "evidence": [ { "id": "Q2YDE4", "url": "https://omabrowser.org/oma/group/Q2YDE4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9QUM9-1", "protein_name": "Proteasome subunit alpha type-6", "gene_name": "Psma6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITESIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD", "length": 246 }, "evidence": [ { "id": "Q2YDE4", "url": "https://omabrowser.org/oma/group/Q2YDE4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9XZJ4-1", "protein_name": "Proteasome subunit alpha type-6", "gene_name": "Prosalpha1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAIAQENITTVALKSGDCAVVATQKKVTEKNIVPETVTHLFRITKDIGCAMTGRIADSRSQVQKARYEAANFRYKYGYEMPVDVLCRRIADINQVYTQNAEMRPLGCSMVLIAYDNEIGPSVYKTDPAGYFSGFKACSVGAKTLEANSYLEKKYKPNLSEEKAIQLAISCLSSVLAIDFKPNGIEIGVVSKSDPTFRILDEREIEEHLTKIAEKD", "length": 244 }, "evidence": [ { "id": "Q2YDE4", "url": "https://omabrowser.org/oma/group/Q2YDE4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE4", "url": "https://www.uniprot.org/uniprotkb/Q2YDE4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE4", "url": "https://www.uniprot.org/uniprotkb/Q2YDE4" } ], "pmid": "" }, { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE4", "url": "https://www.uniprot.org/uniprotkb/Q2YDE4" } ], "pmid": "" }, { "name": "proteasome core complex, alpha-subunit complex", "id": "GO:0019773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019773", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE4", "url": "https://www.uniprot.org/uniprotkb/Q2YDE4" } ], "pmid": "" }, { "name": "proteasome core complex", "id": "GO:0005839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005839", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE4", "url": "https://www.uniprot.org/uniprotkb/Q2YDE4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q2YDE4", "url": "https://www.uniprot.org/uniprotkb/Q2YDE4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDE4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 246, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDE4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDE4" }, { "pdb_id": "1iru", "pdb_chain": "a/o", "start_pos": 1, "end_pos": 246, "overlap": "1.0", "method": "X-Ray_Crystallography", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/1iru.pdb", "url_external": "https://www.rcsb.org/structure/1iru" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 5 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 17, 63, 64, 159 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": 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"total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"uniprot_ac": "Q2YDF9", "uniprot_id": "PCGF1_BOVIN", "mass": { "chemical_mass": 30324.0, "monoisotopic_mass": 30324.0 }, "refseq": { "ac": "NP_001039912", "name": "polycomb group RING finger protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039912" }, "gene_names": [ { "name": "PCGF1", "type": "recommended", "evidence": [ { "id": "Q2YDF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDF9" } ] }, { "name": "PCGF1", "type": "synonym", "evidence": [ { "id": "NP_001039912", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039912" } ] } ], "protein_names": [ { "name": "Polycomb group RING finger protein 1", "type": "recommended", "evidence": [ { "id": "Q2YDF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDF9/entry#names_and_taxonomy" } ] }, { "name": "polycomb group RING finger protein 1", "type": "synonym", "evidence": [ { "id": "NP_001039912", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039912" } ] } ], "function": [ { "annotation": "Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells.", "evidence": [ { "database": "UniProtKB", "id": "Q2YDF9", "url": "https://www.uniprot.org/uniprotkb/Q2YDF9#function" }, { "database": "UniProtKB", "id": "Q9BSM1", "url": "https://www.uniprot.org/uniprotkb/Q9BSM1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDF9", "url": "https://www.uniprot.org/uniprotkb/Q2YDF9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCGF1", "url": "https://www.uniprot.org/uniprotkb/Q2YDF9", "locus": { "chromosome": "11", "start_pos": 10132842, "end_pos": 10130551, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016606", "url": "https://www.ensembl.org/id/ENSBTAG00000016606" } ] } } ], "crossref": [ { "id": "Q2YDF9", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDF9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd16733", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16733", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17081", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17081", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539040", "url": "https://www.ncbi.nlm.nih.gov/gene/539040", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032443", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032443", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539040", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539040", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDF9", "url": "https://www.orthodb.org/?gene=Q2YDF9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10825", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10825", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10825:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10825:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13923", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13923", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16207", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16207", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039912", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDF9", "url": "https://www.uniprot.org/uniprotkb/Q2YDF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDF9-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDF9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASPQGGQIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNHKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGLDRVTQPSGEEPALSNLGLPFSSFDHSKAHYYRYDEQLSLCLERLSSGKDKNKSILQNKYVRCSVRAEVRHLRRVLCHRLMLNPQHVQLLFDNEVLPDHMTMKQIWLSHWFGKPSPLLLQYSVKEKRR", "length": 259, "header": "sp|Q2YDF9-1|PCGF1_BOVIN Isoform 1 of Polycomb group RING finger protein 1 OS=Bos taurus OX=9913 GN=PCGF1 PE=2 SV=2 CANONICAL=Q2YDF9-1" }, "isoforms": [ { "isoform_ac": "Q2YDF9-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDF9/entry#Q2YDF9-1", "sequence": { "sequence": "MASPQGGQIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNHKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGLDRVTQPSGEEPALSNLGLPFSSFDHSKAHYYRYDEQLSLCLERLSSGKDKNKSILQNKYVRCSVRAEVRHLRRVLCHRLMLNPQHVQLLFDNEVLPDHMTMKQIWLSHWFGKPSPLLLQYSVKEKRR", "length": 259, "header": "sp|Q2YDF9-1|PCGF1_BOVIN Isoform 1 of Polycomb group RING finger protein 1 OS=Bos taurus OX=9913 GN=PCGF1 PE=2 SV=2 CANONICAL=Q2YDF9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 3, "end_pos": 3, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2YDF9", "url": "https://www.uniprot.org/uniprotkb/Q2YDF9" } ], "site_lbl": "Ser3" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539040", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539040", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q2YDF9", "url": "https://www.uniprot.org/uniprotkb/Q2YDF9" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "Q2YDF9", "url": "https://www.uniprot.org/uniprotkb/Q2YDF9" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q2YDF9", "url": "https://www.uniprot.org/uniprotkb/Q2YDF9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q2YDF9", "url": "https://www.uniprot.org/uniprotkb/Q2YDF9" } ], "pmid": "" }, { "name": "promoter-specific chromatin binding", "id": "GO:1990841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990841", "evidence": [ { "database": "UniProtKB", "id": "Q2YDF9", "url": "https://www.uniprot.org/uniprotkb/Q2YDF9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "PcG protein complex", "id": "GO:0031519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031519", "evidence": [ { "database": "UniProtKB", "id": "Q2YDF9", "url": "https://www.uniprot.org/uniprotkb/Q2YDF9" } ], "pmid": "" }, { "name": "PRC1 complex", "id": "GO:0035102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035102", "evidence": [ { "database": "UniProtKB", "id": "Q2YDF9", "url": 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Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2YDG3", "url": "https://www.uniprot.org/uniprotkb/Q2YDG3#function" }, { "database": "UniProtKB", "id": "O75794", "url": "https://www.uniprot.org/uniprotkb/O75794#function" }, { "database": "UniProtKB", "id": "Q05791", "url": "https://www.uniprot.org/uniprotkb/Q05791#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDG3", "url": "https://www.uniprot.org/uniprotkb/Q2YDG3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDC123", "url": "https://www.uniprot.org/uniprotkb/Q2YDG3", "locus": { "chromosome": "13", "start_pos": 12143250, "end_pos": 12189634, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019511", "url": "https://www.ensembl.org/id/ENSBTAG00000019511" } ] } } ], "crossref": [ { "id": "Q2YDG3", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDG3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019511", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019511", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514926", "url": "https://www.ncbi.nlm.nih.gov/gene/514926", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514926", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514926", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TFPDPNF", "url": "https://omabrowser.org/oma/group/TFPDPNF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2YDG3", "url": "https://www.orthodb.org/?gene=Q2YDG3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15323", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15323", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15323:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15323:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07065", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07065", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073743", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDG3", "url": "https://www.uniprot.org/uniprotkb/Q2YDG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDG3-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDG3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKKEHVLHCQFSAWYPLFRSLTIKSVILPLPQNVKDYLLDDGTLVVSGREDPPAHSQPDSDDEAEEIQWSDDENTATLTAPEFPEFTTKVQEAINSLGGSVFPKLNWSAPRDAYWIAMNSSLKCKTLSDIFLLFKSSDFITRDFTQPFIHCTDDSPDPCMEYELVLRKWCELIPGAEFRCFVKENKLIGISQRDYTQYYDHISKQKEEICRCIQDFFKKHIQYKFLDEDFVFDIYRDSRGKVWLIDFNPFGEVTDSLLFTWDELLSGTNLKGDFSEEALEQDAPAFRCTNSEVTVQPSPYLSYRLPKDFVDLSTGEDAHKLIDFLKLKRNQQEDD", "length": 335, "header": "sp|Q2YDG3-1|CD123_BOVIN Isoform 1 of Translation initiation factor eIF2 assembly protein OS=Bos taurus OX=9913 GN=CDC123 PE=2 SV=1 CANONICAL=Q2YDG3-1" }, "isoforms": [ { "isoform_ac": "Q2YDG3-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDG3/entry#Q2YDG3-1", "sequence": { "sequence": "MKKEHVLHCQFSAWYPLFRSLTIKSVILPLPQNVKDYLLDDGTLVVSGREDPPAHSQPDSDDEAEEIQWSDDENTATLTAPEFPEFTTKVQEAINSLGGSVFPKLNWSAPRDAYWIAMNSSLKCKTLSDIFLLFKSSDFITRDFTQPFIHCTDDSPDPCMEYELVLRKWCELIPGAEFRCFVKENKLIGISQRDYTQYYDHISKQKEEICRCIQDFFKKHIQYKFLDEDFVFDIYRDSRGKVWLIDFNPFGEVTDSLLFTWDELLSGTNLKGDFSEEALEQDAPAFRCTNSEVTVQPSPYLSYRLPKDFVDLSTGEDAHKLIDFLKLKRNQQEDD", "length": 335, "header": "sp|Q2YDG3-1|CD123_BOVIN Isoform 1 of Translation initiation factor eIF2 assembly protein OS=Bos taurus OX=9913 GN=CDC123 PE=2 SV=1 CANONICAL=Q2YDG3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 60, "end_pos": 60, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2YDG3", "url": "https://www.uniprot.org/uniprotkb/Q2YDG3" } ], "site_lbl": "Ser60" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514926", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514926", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XWM9-1", "protein_name": "Translation initiation factor eIF2 assembly protein", "gene_name": "CDC123", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKKEQVAHCQFSVWYPLFRAVTIRSVILPLPENVKEYLLDDGTLVVSGREDPPTQTPEGSDDAEEIQWSDDENTATLKAPEFPEFTAKVEEAISSLGGSVFPKLNWSAPRDAYWIAMNSSLKCKALSDIFLLFKSSDFITRDLTQPFIHCTDDSPDPSLNYELVLRKWCELIPGAEFRCFVKENKLIGISQRDYTQYYDHISKQHEEICRSIQEFFKKHIQYKFLDEDFVFDVYRDSRGKIWLIDFNPFGEVTDSLLFTWDELTSGRNLKGDQSEVEATEQDYPVFRCTNSQVTVQPSPYLSYRLPKDFVDLSTGEDVHKLIDFLKLKRNQQDDD", "length": 335 }, "evidence": [ { "id": "Q2YDG3", "url": "https://omabrowser.org/oma/group/Q2YDG3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RUP8-1", "protein_name": "Translation initiation factor eIF2 assembly protein", "gene_name": "CDC123", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKKEHVLHCQFSAWYPLFRSLTIKSVILPLPQNVKDYLLDDGTLVVSGREDPPARSQPDSDDEAEEIQWSDDENTATLTAPEFPEFTTKVQEAINSLGGSVFPKLNWSAPRDAYWIAMNSSLKCKTLSDIFLLFKSSDFITRDFTQPFIHCTDDSPDPCMEYELVLRKWCELIPGAEFRCFVKENKLIGISQRDYTQYYDHISKQKEEICRCIQDFFKKHIQYKFLDEDFVFDIYRDSRGKVWLIDFNPFGEVTDALLFTWEELLSGRSVRGDLSEGEAPEQDAPTFRCTNSEVTVQPSPYLSYRLPKDFVDLSTGEDAHKLIDFLKLKRNQQEDD", "length": 336 }, "evidence": [ { "id": "Q2YDG3", "url": "https://omabrowser.org/oma/group/Q2YDG3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O75794-1", "protein_name": "Translation initiation factor eIF2 assembly protein", "gene_name": "CDC123", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKKEHVLHCQFSAWYPFFRGVTIKSVILPLPQNVKDYLLDDGTLVVSGRDDPPTHSQPDSDDEAEEIQWSDDENTATLTAPEFPEFATKVQEAINSLGGSVFPKLNWSAPRDAYWIAMNSSLKCKTLSDIFLLFKSSDFITRDFTQPFIHCTDDSPDPCIEYELVLRKWCELIPGAEFRCFVKENKLIGISQRDYTQYYDHISKQKEEIRRCIQDFFKKHIQYKFLDEDFVFDIYRDSRGKVWLIDFNPFGEVTDSLLFTWEELISENNLNGDFSEVDAQEQDSPAFRCTNSEVTVQPSPYLSYRLPKDFVDLSTGEDAHKLIDFLKLKRNQQEDD", "length": 336 }, "evidence": [ { "id": "Q2YDG3", "url": "https://omabrowser.org/oma/group/Q2YDG3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q05791-1", "protein_name": "Translation initiation factor eIF2 assembly protein", "gene_name": "CDC123", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSSQEYTTFIDIPVTRAQVEHCSYSFWSSLYPKYVPKSIVLKSLPKKFIQYLEQDGIKLPQEENSRSVYTEEIIRNEDNDYSDWEDDEDTATEFVQEVEPLIDFPELHQKLKDALNELGAVAPKLNWSAPRDATWILPNNTMKCNEVNELYLLLNASNYIMHDLQRAFKGCVDGDDIKGLKFDLVLRQWCDMNPALEFRVFVKNAHIVGATQRDLNYYDYLDELSDTFKDLIDEIVHDVVLPKFPDKSFVLDVYIPRPFNKIFIVDINPFARKTDSLLFSWNEIAAIAPPKNDVEDYELRLVTRHNTGRFASKEHSENHVPQDLVEASLNPEAIRELTQKWKELLSQQAKEESSDSENET", "length": 360 }, "evidence": [ { "id": "Q2YDG3", "url": "https://omabrowser.org/oma/group/Q2YDG3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q62834-1", "protein_name": "Translation initiation factor eIF2 assembly protein", "gene_name": "Cdc123", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKKEHVSHCQFSAWYPLFRSLTIKSVILPLPQNVKDYLLDDGTLVVSGREDPPTCSQPDSGDEAEETQWSDDESTATLTAPEFPEFNTQVQEAINSLGGSVFPKLNWSAPRDAYWIAMNSSLKCKSLSDIFLLFKSSDFITHDFTQPFIHCNDDSPDPCIEYELVLRKWCELIPGAEFRCFVKENKLIGISQRDYTQYYDHISKQKEEICRCIQDFFKEHLQYKFLDEDFVFDIYRDSRGKVWLIDFNPFGEVTDSLLFTWEELTSENNLRGDVSEADALEQDSPAFRCTNSEVTVQPSPYLSYGLPKDFVDLSTGEDAHKLIDFLKLKRNQQEDD", "length": 336 }, "evidence": [ { "id": "Q2YDG3", "url": "https://omabrowser.org/oma/group/Q2YDG3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q75JF9-1", "protein_name": "Translation initiation factor eIF2 assembly protein", "gene_name": "cdc123", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEKHDIKYFENKKQCQFQEWYEKFKSVTFSSIVIPLPKIFIDYLQSDQFTTPHEGFPEFKVDEHDDLFDDNNWSTSKNHISTLDPKYYQGYSDEEDESSDDDDSNDNDKDKKPKRIVNETEFKELSNQIIKSIEKLGGNIFPKLNWSSPKDASWMNVYNSLKCTNTTDIYLLLKSSDFINHDLMQFSINQDDKDDSLTPYVLVLRKWQNLQPSMEFRCFVKDNQLLGISQRDISTYFKFLKDKKQKIQDAIVKFYNESICGKFSNNSFTFDCYVTKDEQVWLIDFNPIHPSTEALLFVWDELIPELIEQDQDEKENEETKQAKEELPIEPLTKLEFRIIDDESGIKPNLAMTSRLPLDLLQSSGGTGQGNINDILLNFKNQNLN", "length": 384 }, "evidence": [ { "id": "Q2YDG3", "url": "https://omabrowser.org/oma/group/Q2YDG3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8CII2-1", "protein_name": "Translation initiation factor eIF2 assembly protein", "gene_name": "Cdc123", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKKEHVSHCQFSAWYPLFRSLTIKSVILPLPQNVKDYLLDDGTLVVSGREDPPTCSQSDSGNEAEETQWSDDESTATLTAPEFPEFNTQVQEAINSLGGSVFPKLNWSAPRDAYWIAMNSSLKCKTLSDIFLLFKSSDFITHDFTQPFIHCTDDSPDPCIEYELVLRKWCELIPGAEFRCFVKENKLIGISQRDYTQYYDHISKQKEEICRCIQDFFKEHLQYKFLDEDFVFDIYRDSRGKVWLIDFNPFGEVTDSLLFTWEELTSENNLRGEVTEGDAQEQDSPAFRCTNSEVTVQPSPYLSFGLPKDFVDLSTGEDAHKLIDFLKLKRNEQEDD", "length": 336 }, "evidence": [ { "id": "Q2YDG3", "url": "https://omabrowser.org/oma/group/Q2YDG3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9M0V1-1", "protein_name": "Translation initiation factor eIF2 assembly protein", "gene_name": "EDA35", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MKEDEVNRCQIQNWYPRFKSLTIKTKFHKLPESFINYLIDDSGPFLLPHSVTNEDAMPNRVHNFEEEDDFQVPEEASDDEPLNRPSFPELEIEIRESIETLGGTIIPKLNWSSPKDAAWISPSQNLSCTCFNEIALLFRSSDSLTHDLFNAYDSCSDKVSSRPESFYLALRKWYPSLKPEMEFRCFVKSNELVGICQREVTTFYPVLLNEKDLLKGLIEEFFDDKIRFEFESENYTFDVYVTKERRVKLIDFNTWCGSTLPLMYTWEELEKIHGECDELELRIVESRLSVLPGLKTAVPYDYLDVSAGSGWAQVLKIVEEEFQKDDQSSDEVA", "length": 333 }, "evidence": [ { "id": "Q2YDG3", "url": "https://omabrowser.org/oma/group/Q2YDG3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "Q2YDG3", "url": "https://www.uniprot.org/uniprotkb/Q2YDG3" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q2YDG3", "url": "https://www.uniprot.org/uniprotkb/Q2YDG3" } ], "pmid": "" }, { "name": "protein folding chaperone", "id": "GO:0044183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044183", "evidence": [ { "database": "UniProtKB", "id": "Q2YDG3", "url": "https://www.uniprot.org/uniprotkb/Q2YDG3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2YDG3", "url": "https://www.uniprot.org/uniprotkb/Q2YDG3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "eukaryotic translation initiation factor 2 complex assembly", "id": "GO:1905143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905143", "evidence": [ { "database": "UniProtKB", "id": "Q2YDG3", "url": "https://www.uniprot.org/uniprotkb/Q2YDG3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDG3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 335, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDG3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDG3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q2YDG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDG3#function" }, { "id": "Q2YDG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDG3" } ], "binding_site_uniprot": 246, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 246, "end_pos": 246, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2YDG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDG3#function" }, { "id": "Q2YDG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDG3" } ], "binding_site_uniprot": 248, "amino_acid": "Asn", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 248, "end_pos": 248, "start_aa": "Asn", "end_aa": "Asn", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 60 ], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 119, "end_pos": 121 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDG7-1", "uniprot_ac": "Q2YDG7", "uniprot_id": "SACA1_BOVIN", "mass": { "chemical_mass": 30939.0, "monoisotopic_mass": 30939.0 }, "refseq": { "ac": "NP_001040010", "name": "sperm acrosome membrane-associated protein 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040010" }, "gene_names": [ { "name": "SPACA1", "type": "recommended", "evidence": [ { "id": "Q2YDG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDG7" } ] }, { "name": "SPACA1", "type": "synonym", "evidence": [ { "id": "NP_001040010", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040010" } ] } ], "protein_names": [ { "name": "Sperm acrosome membrane-associated protein 1", "type": "recommended", "evidence": [ { "id": "Q2YDG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDG7/entry#names_and_taxonomy" } ] }, { "name": "sperm acrosome membrane-associated protein 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001040010", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040010" } ] }, { "name": "sperm acrosome membrane-associated protein 1", "type": "synonym", "evidence": [ { "id": "NP_001040010", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040010" } ] } ], "function": [ { "annotation": "Characteristics of bull sperm acrosome associated 1 proteins.", "evidence": [ { "database": "RefSeq", "id": "NP_001040010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040010" }, { "database": "PubMed", "id": "32507260", "url": "https://glygen.org/publication/PubMed/32507260" } ] }, { "annotation": "Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. 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"PTHR47223:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47223:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27947", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27947", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001040010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040010", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDG7", "url": "https://www.uniprot.org/uniprotkb/Q2YDG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDG7-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDG7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKSRGAGCSARLLLTVGWLLLAGLQSTCGINVTAIQDPSLAREGEGEPEGDEEPENDSETEKEPQAEAEDDSEGIGIREVILTSGCPGGESKCIVRVEECRGPVDCGWGRPISESLEHVRLACVHTSPENRFKYIWRLLRPDQQAIILANDSAILEVHRDTHPKAFECETLDNNEIVASIRFTIYTTTELQMKRASRPDTDAVLVFVLTIGVIICIFVIFVLIFIIINWTAVKDFWAKASTTEIQSELSSMRYKDSTSLDQSPTDIPGHEDDALSEWNE", "length": 279, "header": "sp|Q2YDG7-1|SACA1_BOVIN Isoform 1 of Sperm acrosome membrane-associated protein 1 OS=Bos taurus OX=9913 GN=SPACA1 PE=2 SV=1 CANONICAL=Q2YDG7-1" }, "isoforms": [ { "isoform_ac": "Q2YDG7-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDG7/entry#Q2YDG7-1", "sequence": { "sequence": "MKSRGAGCSARLLLTVGWLLLAGLQSTCGINVTAIQDPSLAREGEGEPEGDEEPENDSETEKEPQAEAEDDSEGIGIREVILTSGCPGGESKCIVRVEECRGPVDCGWGRPISESLEHVRLACVHTSPENRFKYIWRLLRPDQQAIILANDSAILEVHRDTHPKAFECETLDNNEIVASIRFTIYTTTELQMKRASRPDTDAVLVFVLTIGVIICIFVIFVLIFIIINWTAVKDFWAKASTTEIQSELSSMRYKDSTSLDQSPTDIPGHEDDALSEWNE", "length": 279, "header": "sp|Q2YDG7-1|SACA1_BOVIN Isoform 1 of Sperm acrosome membrane-associated protein 1 OS=Bos taurus OX=9913 GN=SPACA1 PE=2 SV=1 CANONICAL=Q2YDG7-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 31, "start_aa": "Asn", "end_pos": 31, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn31", "evidence": [ { "id": "Q2YDG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDG7#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 253, "end_pos": 253, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q2YDG7", "url": "https://www.uniprot.org/uniprotkb/Q2YDG7" } ], "site_lbl": "Tyr253" }, { "start_pos": 262, "end_pos": 262, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2YDG7", "url": "https://www.uniprot.org/uniprotkb/Q2YDG7" } ], "site_lbl": "Ser262" }, { "start_pos": 275, "end_pos": 275, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2YDG7", "url": "https://www.uniprot.org/uniprotkb/Q2YDG7" } ], "site_lbl": "Ser275" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characteristics of bull sperm acrosome associated 1 proteins.", "journal": "Animal reproduction science", "date": "2020-07", "authors": "Minami Kenta, Arai-Aso Miyuki M, Ogura-Kodama Yukari, Yamada Ayano, Kishida Kazumi, Sakase Mitsuhiro, Fukushima Moriyuki, Harayama Hiroshi", "evidence": [ { "database": "RefSeq", "id": "NP_001040010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040010" } ], "reference": [ { "type": "PubMed", "id": "32507260", "url": "https://glygen.org/publication/PubMed/32507260" } ] } ], "pathway": [ { "id": "bta:614884", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614884", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "acrosomal membrane", "id": "GO:0002080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002080", "evidence": [ { "database": "UniProtKB", "id": "Q2YDG7", "url": "https://www.uniprot.org/uniprotkb/Q2YDG7" } ], "pmid": "" }, { "name": "inner acrosomal membrane", "id": "GO:0002079", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002079", "evidence": [ { "database": "UniProtKB", "id": "Q2YDG7", "url": "https://www.uniprot.org/uniprotkb/Q2YDG7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "acrosome assembly", "id": "GO:0001675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001675", "evidence": [ { "database": "UniProtKB", "id": "Q2YDG7", "url": "https://www.uniprot.org/uniprotkb/Q2YDG7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 150, "end_pos": 152, "annotation": "n_glycosylation_sequon" }, { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" }, { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDG7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 279, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDG7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDG7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 31 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 253, 262, 275 ], "sequon_annotation_sites": [ { "start_pos": 150, "end_pos": 152 }, { "start_pos": 228, "end_pos": 230 }, { "start_pos": 31, "end_pos": 33 }, { "start_pos": 56, "end_pos": 58 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", 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"table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q2YDH1-1", "uniprot_ac": "Q2YDH1", "uniprot_id": "APC10_BOVIN", "mass": { "chemical_mass": 21252.0, "monoisotopic_mass": 21252.0 }, "refseq": { "ac": "NP_001073826", "name": "anaphase-promoting complex subunit 10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073826" }, "gene_names": [ { "name": "ANAPC10", "type": "recommended", "evidence": [ { "id": "Q2YDH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDH1" } ] }, { "name": "ANAPC10", "type": "synonym", "evidence": [ { "id": "NP_001073826", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073826" } ] }, { "name": "APC10", "type": "synonym", "evidence": [ { "id": "Q2YDH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDH1" } ] } ], "protein_names": [ { "name": "Anaphase-promoting complex subunit 10", "type": "recommended", "evidence": [ { "id": "Q2YDH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDH1/entry#names_and_taxonomy" } ] }, { "name": "APC10", "type": "synonym", "evidence": [ { "id": "NP_001073826", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073826" }, { "id": "Q2YDH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDH1/entry#names_and_taxonomy" } ] }, { "name": "Cyclosome subunit 10", "type": "synonym", "evidence": [ { "id": "Q2YDH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDH1/entry#names_and_taxonomy" } ] }, { "name": "anaphase-promoting complex subunit 10", "type": "synonym", "evidence": [ { "id": "NP_001073826", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073826" } ] }, { "name": "cyclosome subunit 10", "type": "synonym", "evidence": [ { "id": "NP_001073826", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073826" } ] } ], "function": [ { "annotation": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2YDH1", "url": "https://www.uniprot.org/uniprotkb/Q2YDH1#function" }, { "database": "UniProtKB", "id": "Q9UM13", "url": "https://www.uniprot.org/uniprotkb/Q9UM13#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDH1", "url": "https://www.uniprot.org/uniprotkb/Q2YDH1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANAPC10", "url": "https://www.uniprot.org/uniprotkb/Q2YDH1", "locus": { "chromosome": "17", "start_pos": 13350328, "end_pos": 13187173, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013326", "url": "https://www.ensembl.org/id/ENSBTAG00000013326" } ] } } ], "crossref": [ { "id": "Q2YDH1", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDH1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd08366", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08366", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "783986", "url": "https://www.ncbi.nlm.nih.gov/gene/783986", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004939", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016901", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016901", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:783986", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783986", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDH1", "url": "https://www.orthodb.org/?gene=Q2YDH1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12936", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12936", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12936:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12936:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03256", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03256", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073826", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDH1", "url": "https://www.uniprot.org/uniprotkb/Q2YDH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDH1-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDH1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTPNKTPPGADPKQLERTGTVREIGSQAVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQPHLVNLQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNFHNLQEIRQLELVEPSGWIHVPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYTPVEESSIGKFPRCTTIDFMMYRSIR", "length": 185, "header": "sp|Q2YDH1-1|APC10_BOVIN Isoform 1 of Anaphase-promoting complex subunit 10 OS=Bos taurus OX=9913 GN=ANAPC10 PE=2 SV=1 CANONICAL=Q2YDH1-1" }, "isoforms": [ { "isoform_ac": "Q2YDH1-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDH1/entry#Q2YDH1-1", "sequence": { "sequence": "MTTPNKTPPGADPKQLERTGTVREIGSQAVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQPHLVNLQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNFHNLQEIRQLELVEPSGWIHVPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYTPVEESSIGKFPRCTTIDFMMYRSIR", "length": 185, "header": "sp|Q2YDH1-1|APC10_BOVIN Isoform 1 of Anaphase-promoting complex subunit 10 OS=Bos taurus OX=9913 GN=ANAPC10 PE=2 SV=1 CANONICAL=Q2YDH1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:783986", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783986", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q2YDH1", "url": "https://www.uniprot.org/uniprotkb/Q2YDH1" } ], "pmid": "" }, { "name": "anaphase-promoting complex-dependent catabolic process", "id": "GO:0031145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031145", "evidence": [ { "database": "UniProtKB", "id": "Q2YDH1", "url": "https://www.uniprot.org/uniprotkb/Q2YDH1" } ], "pmid": "" }, { "name": "protein K11-linked ubiquitination", "id": "GO:0070979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070979", "evidence": [ { "database": "UniProtKB", "id": "Q2YDH1", "url": "https://www.uniprot.org/uniprotkb/Q2YDH1" } ], "pmid": "" }, { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "Q2YDH1", "url": "https://www.uniprot.org/uniprotkb/Q2YDH1" } ], "pmid": "" }, { "name": "protein branched polyubiquitination", "id": "GO:0141198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141198", "evidence": [ { "database": "UniProtKB", "id": "Q2YDH1", "url": "https://www.uniprot.org/uniprotkb/Q2YDH1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "anaphase-promoting complex", "id": "GO:0005680", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005680", "evidence": [ { "database": "UniProtKB", "id": "Q2YDH1", "url": "https://www.uniprot.org/uniprotkb/Q2YDH1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDH1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 185, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDH1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDH1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2YDH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDH1" }, { "id": "PRU00614", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00614" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DOC", "eco_id": "ECO_0000255", "start_pos": 2, "end_pos": 185, "start_aa": "Thr", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDH6-1", "uniprot_ac": "Q2YDH6", "uniprot_id": "AP3S1_BOVIN", "mass": { "chemical_mass": 21732.0, "monoisotopic_mass": 21732.0 }, "refseq": { "ac": "NP_001039881", "name": "AP-3 complex subunit sigma-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039881" }, "gene_names": [ { "name": "AP3S1", "type": "recommended", "evidence": [ { "id": "Q2YDH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDH6" } ] }, { "name": "AP3S1", "type": "synonym", "evidence": [ { "id": "NP_001039881", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039881" } ] } ], "protein_names": [ { "name": "AP-3 complex subunit sigma-1", "type": "recommended", "evidence": [ { "id": "Q2YDH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDH6/entry#names_and_taxonomy" } ] }, { "name": "AP-3 complex sigma-3A subunit", "type": "synonym", "evidence": [ { "id": "NP_001039881", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039881" } ] }, { "name": "AP-3 complex subunit sigma-1", "type": "synonym", "evidence": [ { "id": "NP_001039881", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039881" } ] }, { "name": "AP-3 complex subunit sigma-3A", "type": "synonym", "evidence": [ { "id": "NP_001039881", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039881" }, { "id": "Q2YDH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDH6/entry#names_and_taxonomy" } ] }, { "name": "Adaptor-related protein complex 3 subunit sigma-1", "type": "synonym", "evidence": [ { "id": "Q2YDH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDH6/entry#names_and_taxonomy" } ] }, { "name": "Sigma 3A-adaptin", "type": "synonym", "evidence": [ { "id": "Q2YDH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDH6/entry#names_and_taxonomy" } ] }, { "name": "Sigma-adaptin 3a", "type": "synonym", "evidence": [ { "id": "Q2YDH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDH6/entry#names_and_taxonomy" } ] }, { "name": "adapter-related protein complex 3 sigma-1 subunit", "type": "synonym", "evidence": [ { "id": "NP_001039881", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039881" } ] }, { "name": "adapter-related protein complex 3 subunit sigma-1", "type": "synonym", "evidence": [ { "id": "NP_001039881", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039881" } ] }, { "name": "adaptor-related protein complex 3, sigma 1 subunit", "type": "synonym", "evidence": [ { "id": "NP_001039881", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039881" } ] }, { "name": "sigma 3A-adaptin", "type": "synonym", "evidence": [ { "id": "NP_001039881", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039881" } ] }, { "name": "sigma-adaptin 3a", "type": "synonym", "evidence": [ { "id": "NP_001039881", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039881" } ] } ], "function": [ { "annotation": "Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2YDH6", "url": "https://www.uniprot.org/uniprotkb/Q2YDH6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDH6", "url": "https://www.uniprot.org/uniprotkb/Q2YDH6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AP3S1", "url": "https://www.uniprot.org/uniprotkb/Q2YDH6", "locus": {} } ], "crossref": [ { "id": "Q2YDH6", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDH6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051386", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051386", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14834", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14834", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "536359", "url": "https://www.ncbi.nlm.nih.gov/gene/536359", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000804", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000804", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016635", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016635", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027155", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027155", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536359", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536359", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DLIFNWQ", "url": "https://omabrowser.org/oma/group/DLIFNWQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2YDH6", "url": "https://www.orthodb.org/?gene=Q2YDH6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11753", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11753", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01217", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01217", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-432722", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432722", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001039881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039881", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDH6", "url": "https://www.uniprot.org/uniprotkb/Q2YDH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDH6-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDH6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK", "length": 193, "header": "sp|Q2YDH6-1|AP3S1_BOVIN Isoform 1 of AP-3 complex subunit sigma-1 OS=Bos taurus OX=9913 GN=AP3S1 PE=2 SV=1 CANONICAL=Q2YDH6-1" }, "isoforms": [ { "isoform_ac": "Q2YDH6-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDH6/entry#Q2YDH6-1", "sequence": { "sequence": "MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK", "length": 193, "header": "sp|Q2YDH6-1|AP3S1_BOVIN Isoform 1 of AP-3 complex subunit sigma-1 OS=Bos taurus OX=9913 GN=AP3S1 PE=2 SV=1 CANONICAL=Q2YDH6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 191, "end_pos": 191, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2YDH6", "url": "https://www.uniprot.org/uniprotkb/Q2YDH6" } ], "site_lbl": "Ser191" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:536359", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536359", "resource": "KEGG Pathway" }, { "id": "R-BTA-432722", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432722", "resource": "Reactome", "description": "Golgi Associated Vesicle Biogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1U712-1", "protein_name": "Adaptor related protein complex 3 subunit sigma 1", "gene_name": "AP3S1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK", "length": 193 }, "evidence": [ { "id": "Q2YDH6", "url": "https://omabrowser.org/oma/group/Q2YDH6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6AKR4-1", "protein_name": "Adaptor related protein complex 3 subunit sigma 1", "gene_name": "Ap3s1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "GPFPPFPDFSILKLLSFIFRIEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK", "length": 190 }, "evidence": [ { "id": "Q2YDH6", "url": "https://omabrowser.org/oma/group/Q2YDH6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P47064-1", "protein_name": "AP-3 complex subunit sigma", "gene_name": "APS3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MIHAVLIFNKKCQPRLVKFYTPVDLPKQKLLLEQVYELISQRNSDFQSSFLVTPPSLLLSNENNNDEVNNEDIQIIYKNYATLYFTFIVDDQESELAILDLIQTFVESLDRCFTEVNELDLIFNWQTLESVLEEIVQGGMVIETNVNRIVASVDELNKAAESTDSKIGRLTSTGFGSALQAFAQGGFAQWATGQ", "length": 194 }, "evidence": [ { "id": "Q2YDH6", "url": "https://omabrowser.org/oma/group/Q2YDH6/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q553S2-1", "protein_name": "AP-3 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"common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q92572-1", "protein_name": "AP-3 complex subunit sigma-1", "gene_name": "AP3S1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK", "length": 193 }, "evidence": [ { "id": "Q2YDH6", "url": "https://omabrowser.org/oma/group/Q2YDH6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DCR2-1", "protein_name": "AP-3 complex subunit sigma-1", "gene_name": "Ap3s1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK", "length": 193 }, "evidence": [ { "id": "Q2YDH6", "url": "https://omabrowser.org/oma/group/Q2YDH6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q2YDH6", "url": "https://www.uniprot.org/uniprotkb/Q2YDH6" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "Q2YDH6", "url": "https://www.uniprot.org/uniprotkb/Q2YDH6" } ], "pmid": "" }, { "name": "AP-3 adaptor complex", "id": "GO:0030123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030123", "evidence": [ { "database": "UniProtKB", "id": "Q2YDH6", "url": "https://www.uniprot.org/uniprotkb/Q2YDH6" } ], "pmid": "" }, { "name": "axon cytoplasm", "id": "GO:1904115", "url": 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"https://www.uniprot.org/uniprotkb/Q2YDI0", "locus": { "chromosome": "29", "start_pos": 44481514, "end_pos": 44484873, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000069463", "url": "https://www.ensembl.org/id/ENSBTAG00000069463" } ] } } ], "crossref": [ { "id": "Q2YDI0", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDI0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000053687", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000053687", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00349", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00349", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515990", "url": "https://www.ncbi.nlm.nih.gov/gene/515990", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "2FTC", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=2FTC&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { 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Classification" ] }, { "id": "IPR036796", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036796", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515990", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515990", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CKQFNAK", "url": "https://omabrowser.org/oma/group/CKQFNAK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2YDI0", "url": "https://www.orthodb.org/?gene=Q2YDI0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11661", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11661", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11661:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11661:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00002ftc", "url": "https://www.rcsb.org/structure/pdb_00002ftc", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00003iy9", "url": "https://www.rcsb.org/structure/pdb_00003iy9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2FTC", "url": "https://www.rcsb.org/structure/2FTC", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3IY9", "url": "https://www.rcsb.org/structure/3IY9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00298", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00298", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03946", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03946", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9937383", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001014932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014932", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDI0", "url": "https://www.uniprot.org/uniprotkb/Q2YDI0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDI0-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDI0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKLSRATRALRKPEAEGVIRTILRAGQAMPGPPLGPILGQRGVSINQFCKEFNEKTKDIKEGIPLPTKIFVKPDRTFEIKIGQPTVSYFLKAAAGIEKGARNTGKEVAGLVTLKHVYEIARVKAQDDAFALQDVPLSSVVRSIIGSARSLGIRVVKDLSSEELAAFQKERALFLAAQKEADLAAQAEAAKK", "length": 192, "header": "sp|Q2YDI0-1|RM11_BOVIN Isoform 1 of Large ribosomal subunit protein uL11m OS=Bos taurus OX=9913 GN=MRPL11 PE=1 SV=2 CANONICAL=Q2YDI0-1" }, "isoforms": [ { "isoform_ac": "Q2YDI0-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDI0/entry#Q2YDI0-1", "sequence": { "sequence": "MSKLSRATRALRKPEAEGVIRTILRAGQAMPGPPLGPILGQRGVSINQFCKEFNEKTKDIKEGIPLPTKIFVKPDRTFEIKIGQPTVSYFLKAAAGIEKGARNTGKEVAGLVTLKHVYEIARVKAQDDAFALQDVPLSSVVRSIIGSARSLGIRVVKDLSSEELAAFQKERALFLAAQKEADLAAQAEAAKK", "length": 192, "header": "sp|Q2YDI0-1|RM11_BOVIN Isoform 1 of Large ribosomal subunit protein uL11m OS=Bos taurus OX=9913 GN=MRPL11 PE=1 SV=2 CANONICAL=Q2YDI0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Suzuki T, Terasaki M, Takemoto-Hori C, Hanada T, Ueda T, Wada A, Watanabe K", "evidence": [ { "database": "UniProtKB", "id": "Q2YDI0", "url": "https://www.uniprot.org/uniprotkb/Q2YDI0" } ], "reference": [ { "type": "PubMed", "id": "11279069", "url": "https://glygen.org/publication/PubMed/11279069" } ] }, { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q2YDI0", "url": "https://www.uniprot.org/uniprotkb/Q2YDI0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "A structural model for the large subunit of the mammalian mitochondrial ribosome.", "journal": "J. Mol. Biol.", "date": "2006", "authors": "Mears Jason A, Sharma Manjuli R, Gutell Robin R, McCook Amanda S, Richardson Paul E, Caulfield Thomas R, Agrawal Rajendra K, Harvey Stephen C", "evidence": [ { "database": "UniProtKB", "id": "Q2YDI0", "url": "https://www.uniprot.org/uniprotkb/Q2YDI0" } ], "reference": [ { "type": "PubMed", "id": "16510155", "url": "https://glygen.org/publication/PubMed/16510155" } ] } ], "pathway": [ { "id": "bta:515990", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515990", "resource": "KEGG Pathway" }, { "id": "R-BTA-5389840", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-9937383", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "resource": "Reactome", "description": "Mitochondrial ribosome-associated quality control" } ], "orthologs": [ { "uniprot_canonical_ac": "G3I2H2-1", "protein_name": "Large ribosomal subunit protein uL11m", "gene_name": "Mrpl11", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSKLSRVSRALRKPEAGGVVRAIVRAGQAMPGPPLGPILGQRGVSINQFCKEFNEKTKDIKEGIPLPTKIFVKPDRTFELKIGQPTISYFLKAAAGIEKGARQTGKEVAGLVSLKHIYEIACVKAKDDAFALQDVPLSSVVRSIIGSARSLGIRVVKDLSAEELAAFQKERAVVLAAQKEADLAAQAAAAKK", "length": 192 }, "evidence": [ { "id": "Q2YDI0", "url": "https://omabrowser.org/oma/group/Q2YDI0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P53875-1", "protein_name": "Large ribosomal subunit protein uL11m", "gene_name": "MRPL19", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSQAAKNVIVKLIVGAGQAAPSPPVGPALGSKGIKAIDFCKEFNARSANYQPGVPVPVLITIKPDRTFTFEMKSPPTGYLLLKALKMDKGHGQPNVGTMLGSAPAKGPTRALGELSLKHVYEIAKIKKSDERHSLLEMEGIVKSIVGVAKSMGIKVVP", "length": 158 }, "evidence": [ { "id": "Q2YDI0", "url": "https://omabrowser.org/oma/group/Q2YDI0/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q5XIE3-1", "protein_name": "Large ribosomal subunit protein uL11m", "gene_name": "Mrpl11", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSKLSRVTRTLKKPEAGGVIRSIVRAGQAIPGPPLGPILGQRGVSINQFCKEFNEKTKDIKEGIPLPTKIFIKPDRTFELKIGQPTISYFLKAAAGIEKGARQTGKEVAGLVSLKHVYEIARVKAKDEAFAMQDVPLSSIVRSIIGSARSLGIRVVKDLSVDELAAFQKERAVFLAAQKRRIWQLRQKLPKSDPNLLHSEVRD", "length": 203 }, "evidence": [ { "id": "Q2YDI0", "url": "https://omabrowser.org/oma/group/Q2YDI0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CQF0-1", "protein_name": "Large ribosomal subunit protein 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"id": "Q2YDI9", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDI9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01056", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01056", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539838", "url": "https://www.ncbi.nlm.nih.gov/gene/539838", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009040", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009040", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009078", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009078", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539838", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539838", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDI9", "url": "https://www.orthodb.org/?gene=Q2YDI9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11431", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11431", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11431:SF30", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11431:SF30", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00210", "url": 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Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ4", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ4#function" }, { "database": "UniProtKB", "id": "Q9NQE9", "url": "https://www.uniprot.org/uniprotkb/Q9NQE9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ4", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HINT3", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ4", "locus": { "chromosome": "9", "start_pos": 25326267, "end_pos": 25340234, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001956", "url": 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"https://www.genome.jp/dbget-bin/www_bget?bta:281817", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EKKCIFC", "url": "https://omabrowser.org/oma/group/EKKCIFC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q2YDJ4", "url": "https://www.orthodb.org/?gene=Q2YDJ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12486", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12486", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12486:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12486:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11969", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11969", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_776766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776766", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "67916", "url": "https://www.rhea-db.org/rhea/67916", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDJ4", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDJ4-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMEEEECGLGKSCARSEPVAAAQPAGSPGETPAVAAESPELANYSSKCVFCRIAAHQDPGTELLHCENEDLVCFKDIKPAAPHHYLVVPKKHFENCKYLKKDQIELIENMVTVGKAILERNNFTDFENTRMGFHVSPFCSIAHLHLHVLAPADQLSFMSRLVYRVNSYWFITADYLIEKLRT", "length": 182, "header": "sp|Q2YDJ4-1|HINT3_BOVIN Isoform 1 of Adenosine 5'-monophosphoramidase HINT3 OS=Bos taurus OX=9913 GN=HINT3 PE=2 SV=1 CANONICAL=Q2YDJ4-1" }, "isoforms": [ { "isoform_ac": "Q2YDJ4-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ4/entry#Q2YDJ4-1", "sequence": { "sequence": "MMEEEECGLGKSCARSEPVAAAQPAGSPGETPAVAAESPELANYSSKCVFCRIAAHQDPGTELLHCENEDLVCFKDIKPAAPHHYLVVPKKHFENCKYLKKDQIELIENMVTVGKAILERNNFTDFENTRMGFHVSPFCSIAHLHLHVLAPADQLSFMSRLVYRVNSYWFITADYLIEKLRT", "length": 182, "header": "sp|Q2YDJ4-1|HINT3_BOVIN Isoform 1 of Adenosine 5'-monophosphoramidase HINT3 OS=Bos taurus OX=9913 GN=HINT3 PE=2 SV=1 CANONICAL=Q2YDJ4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:281817", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281817", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1L1RRE8-1", "protein_name": "Adenosine 5'-monophosphoramidase HINT3", "gene_name": "HINT3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGEEAAAAAGPGGEQLLAASGGYDGKCVFCRIARREEPGTALLPCQYEDLVCFRDIRPGAPHHYLVVPVEHMGNCKTLKSEHVPIVKRMMEVGKSVLQKNNFSDLNDIRMGFHWPPFCSISHLHLHVLAPASQLGFLSRLIYRINSYWFITAEQLIERLQTEHAAS", "length": 167 }, "evidence": [ { "id": "Q2YDJ4", "url": "https://omabrowser.org/oma/group/Q2YDJ4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8D0XGE2-1", "protein_name": "Adenosine 5'-monophosphoramidase HINT3", "gene_name": "HINT3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAEEWEGDFAKSCARLEAAATADTSGSPAGTTTVAAESSEREGYSRKCVFCRIAGQQEPGTELLYCENEDLVCFKDIKPAAPHHYLVAPKKHIVNCNYLKKDQIGLVENMVTVGKTILERNNFTDFNNIRMGFHIPPFCSISHLHLHVLAPVDHLSFLSRLVYKENSYWFITADYLIEKLRT", "length": 182 }, "evidence": [ { "id": "Q2YDJ4", "url": "https://omabrowser.org/oma/group/Q2YDJ4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0AB32T7V2-1", "protein_name": "Adenosine 5'-monophosphoramidase HINT3", "gene_name": "hint3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MADAANTPTPESCIASHSDEEYDKKCIFCKILKGEMGTELLHSDETVSCFQDIHPGAPHHYLVVPSKHVGNCKSLSKEHVPLVEKMLETGKEILEKNNVTDLSDVRFGFHWPPFCSVTHLHLHVLAPVSQMGFMSRLIYRLNSYWFVTLQAGGRRGVANGSQAGSLRPRI", "length": 170 }, "evidence": [ { "id": "Q2YDJ4", "url": "https://omabrowser.org/oma/group/Q2YDJ4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q54DF5-1", "protein_name": "HIT domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNSISIRSAAVYSSLILNLLLIVGSNTMKKKPTTQGCPFCDYPNDKIIFQNVIVFNDRTPKATVHYLICPREHIVSIKTLTQKDIPVLVEMKQVADQLIAEKFPGQSGIVLGFHSPPFYSVKHLHLHLLVPPFTPKFKKHSYAPHFGGLWFKDVNTVINELYNSVA", "length": 166 }, "evidence": [ { "id": "Q2YDJ4", "url": "https://omabrowser.org/oma/group/Q2YDJ4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q84VV6-1", "protein_name": "Bifunctional adenosine 5'-phosphosulfate phosphorylase/adenylylsulfatase HINT4", "gene_name": "HINT4", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAGVNQACIFCEIVRNPTTTRLLHTDEKVIAFQDIKPAAQRHYLVIPKEHIPTVNDLQRRDEDYSLVRHMLSVGQQLLQKDAPQSIHRFGFHQPPFNSVDHLHLHCFALPYVPRWKAIKYKSLGPLGGFIEAETLLEKIRPLLSKV", "length": 146 }, "evidence": [ { "id": "Q2YDJ4", "url": "https://omabrowser.org/oma/group/Q2YDJ4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q8K3P7-1", "protein_name": "Adenosine 5'-monophosphoramidase HINT3", "gene_name": "Hint3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEKQAGLAGEPNPDCTVTAKAGPEVSSPGTSESRDYDSNCVFCRVAAGQEPETELLYCENKDLVCFKDIKPAALHHYLVVPKKHIGSCKDLNKDHIEMVESMVTVGKTILERNNFTDFTDVRMGFHVPPFCSVSHLHLHVIAPAKEFGFLSRVVYRRDSYWFITGDYLLEKLRK", "length": 175 }, "evidence": [ { "id": "Q2YDJ4", "url": "https://omabrowser.org/oma/group/Q2YDJ4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CPS6-1", "protein_name": "Adenosine 5'-monophosphoramidase HINT3", "gene_name": "Hint3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEKQAGLVGEPDPEGSSPGTSESWNYDSNCVFCRVAAGQEPKTELFHCENEDLVCFKDIKPAALYHYLVVPKKHIGSCKDLNKDHIEMVESMVAAGKTMLERNNFTDFTDVRMGFHVPPFCSISHLHLHVIAPVKEFGFLSKLVYRQDSYWFVTVDYLLEKLRK", "length": 165 }, "evidence": [ { "id": "Q2YDJ4", "url": "https://omabrowser.org/oma/group/Q2YDJ4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NQE9-1", "protein_name": "Adenosine 5'-monophosphoramidase HINT3", "gene_name": "HINT3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEEQVNRSAGLAPDCEASATAETTVSSVGTCEAAGKSPEPKDYDSTCVFCRIAGRQDPGTELLHCENEDLICFKDIKPAATHHYLVVPKKHIGNCRTLRKDQVELVENMVTVGKTILERNNFTDFTNVRMGFHMPPFCSISHLHLHVLAPVDQLGFLSKLVYRVNSYWFITADHLIEKLRT", "length": 182 }, "evidence": [ { "id": "Q2YDJ4", "url": "https://omabrowser.org/oma/group/Q2YDJ4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ4", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ4", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "nucleotide binding", "id": "GO:0000166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000166", "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ4", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ4" } ], "pmid": "" }, { "name": "adenosine 5'-monophosphoramidase activity", "id": "GO:0043530", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043530", "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ4", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "67916", "name": "", "equation": "adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8SQ21-1", "P62958-1", "Q1KZG4-1", "Q2YDJ4-1" ], "evidence": [ { "id": "67916", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67916" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P62958", "gene_name": "HINT1", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "P62958", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62958" } ] }, { "ec_number": "3.9.1.-", "activity": "", "evidence": [ { "id": "P62958", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62958" } ] } ] }, { "uniprot_ac": "Q1KZG4", "gene_name": "FHIT", "activity": [ { "ec_number": "3.6.1.29", "activity": "P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+).", "evidence": [ { "id": "Q1KZG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1KZG4" } ] }, { "ec_number": "3.6.1.29", "activity": "", "evidence": [ { "id": "Q1KZG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1KZG4" } ] }, { "ec_number": "2.7.7.51", "activity": "adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + sulfate + 2 H(+).", "evidence": [ { "id": "Q1KZG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1KZG4" } ] }, { "ec_number": "3.6.2.1", "activity": "adenosine 5'-phosphosulfate + H2O = sulfate + AMP + 2 H(+).", "evidence": [ { "id": "Q1KZG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1KZG4" } ] }, { "ec_number": "2.7.7.51", "activity": "", "evidence": [ { "id": "Q1KZG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1KZG4" } ] }, { "ec_number": "3.6.2.1", "activity": "", "evidence": [ { "id": "Q1KZG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1KZG4" } ] }, { "ec_number": "3.9.1.-", "activity": "", "evidence": [ { "id": "Q1KZG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1KZG4" } ] } ] }, { "uniprot_ac": "Q2YDJ4", "gene_name": "HINT3", "activity": [ { "ec_number": "3.9.1.-", "activity": "", "evidence": [ { "id": "Q2YDJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ4" } ] } ] }, { "uniprot_ac": "Q8SQ21", "gene_name": "HINT2", "activity": [ { "ec_number": "3.9.1.-", "activity": "", "evidence": [ { "id": "Q8SQ21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SQ21" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDJ4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 182, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDJ4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDJ4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2YDJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ4" }, { "id": "PRU00464", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00464" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HIT", "eco_id": "ECO_0000255", "start_pos": 49, "end_pos": 158, "start_aa": "Val", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 122, "end_pos": 124 }, { "start_pos": 43, "end_pos": 45 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDJ9-1", "uniprot_ac": "Q2YDJ9", "uniprot_id": "GMPPB_BOVIN", "mass": { "chemical_mass": 39837.0, "monoisotopic_mass": 39837.0 }, "refseq": { "ac": "NP_001039633", "name": "mannose-1-phosphate guanylyltransferase catalytic subunit beta", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039633" }, "gene_names": [ { "name": "GMPPB", "type": "recommended", "evidence": [ { "id": "Q2YDJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9" } ] }, { "name": "GMPPB", "type": "synonym", "evidence": [ { "id": "NP_001039633", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039633" } ] } ], "protein_names": [ { "name": "Mannose-1-phosphate guanylyltransferase catalytic subunit beta", "type": "recommended", "evidence": [ { "id": "Q2YDJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9/entry#names_and_taxonomy" } ] }, { "name": "2.7.7.13", "type": "synonym", "evidence": [ { "id": "Q2YDJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9/entry#names_and_taxonomy" } ] }, { "name": "GDP-mannose pyrophosphorylase B", "type": "synonym", "evidence": [ { "id": "Q2YDJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9/entry#names_and_taxonomy" } ] }, { "name": "GTP-mannose-1-phosphate guanylyltransferase beta", "type": "synonym", "evidence": [ { "id": "NP_001039633", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039633" }, { "id": "Q2YDJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9/entry#names_and_taxonomy" } ] }, { "name": "mannose-1-phosphate guanyltransferase beta", "type": "synonym", "evidence": [ { "id": "NP_001039633", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039633" } ] }, { "name": "mannose-1-phosphate guanylyltransferase catalytic subunit beta", "type": "synonym", "evidence": [ { "id": "NP_001039633", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039633" } ] } ], "function": [ { "annotation": "Catalytic subunit of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex (By similarity). Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids (By similarity). Can catalyze the reverse reaction in vitro (By similarity). Together with GMPPA regulates GDP-alpha-D-mannose levels (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ9", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9#function" }, { "database": "UniProtKB", "id": "P0C5I2", "url": "https://www.uniprot.org/uniprotkb/P0C5I2#function" }, { "database": "UniProtKB", "id": "Q9Y5P6", "url": "https://www.uniprot.org/uniprotkb/Q9Y5P6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ9", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GMPPB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9", "locus": { "chromosome": "22", "start_pos": 50484009, "end_pos": 50481628, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032026", "url": "https://www.ensembl.org/id/ENSBTAG00000032026" } ] } } ], "crossref": [ { "id": "Q2YDJ9", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDJ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06425", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06425", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514161", "url": "https://www.ncbi.nlm.nih.gov/gene/514161", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005835", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005835", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045233", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045233", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050486", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050486", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514161", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514161", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDJ9", "url": "https://www.orthodb.org/?gene=Q2YDJ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22572", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22572", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00483", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00483", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25087", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25087", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039633", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039633", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "15229", "url": "https://www.rhea-db.org/rhea/15229", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDJ9", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDJ9-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKALILVGGYGTRLRPLTLSIPKPLADFCNKPILLHQVEALAAAGVDHVILAVSYMSQVLEKEMKAQEQKLGIRISMSHEEEPLGTAGPLALARDLLCETADPFFVLNSDVICDFPFEAMVQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRVHRFVEKPQVFVSNKINAGVYILSPSVLRRIQLQPTSIEKEIFPVMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLKSLRQKHPEQLCSGPGIVGNVLVDPRARIGENCSIGPNVSLGPGVVVEDGVCIRRCTVLRDAHIRSHSWLESCIVGWRCRVGQWVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGESVPEPRIIM", "length": 360, "header": "sp|Q2YDJ9-1|GMPPB_BOVIN Isoform 1 of Mannose-1-phosphate guanylyltransferase catalytic subunit beta OS=Bos taurus OX=9913 GN=GMPPB PE=2 SV=1 CANONICAL=Q2YDJ9-1" }, "isoforms": [ { "isoform_ac": "Q2YDJ9-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9/entry#Q2YDJ9-1", "sequence": { "sequence": "MKALILVGGYGTRLRPLTLSIPKPLADFCNKPILLHQVEALAAAGVDHVILAVSYMSQVLEKEMKAQEQKLGIRISMSHEEEPLGTAGPLALARDLLCETADPFFVLNSDVICDFPFEAMVQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRVHRFVEKPQVFVSNKINAGVYILSPSVLRRIQLQPTSIEKEIFPVMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLKSLRQKHPEQLCSGPGIVGNVLVDPRARIGENCSIGPNVSLGPGVVVEDGVCIRRCTVLRDAHIRSHSWLESCIVGWRCRVGQWVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGESVPEPRIIM", "length": 360, "header": "sp|Q2YDJ9-1|GMPPB_BOVIN Isoform 1 of Mannose-1-phosphate guanylyltransferase catalytic subunit beta OS=Bos taurus OX=9913 GN=GMPPB PE=2 SV=1 CANONICAL=Q2YDJ9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:514161", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514161", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "mannose-1-phosphate guanylyltransferase (GTP) activity", "id": "GO:0004475", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004475", "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ9", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ9", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ9", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ9", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9" } ], "pmid": "" }, { "name": "GDP-mannose pyrophosphorylase complex", "id": "GO:0120508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120508", "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ9", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "GDP-mannose biosynthetic process", "id": "GO:0009298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009298", "evidence": [ { "database": "UniProtKB", "id": "Q2YDJ9", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 265, "end_pos": 267, "annotation": "n_glycosylation_sequon" }, { "start_pos": 271, "end_pos": 273, "annotation": "n_glycosylation_sequon" }, { "start_pos": 322, "end_pos": 324, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15229", "name": "", "equation": "alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2YDJ9-1", "A0AAA9STQ0-1" ], "evidence": [ { "id": "15229", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15229" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9STQ0", "gene_name": "GMPPB", "activity": [ { "ec_number": "2.7.7.13", "activity": "alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate.", "evidence": [ { "id": "A0AAA9STQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ0" } ] }, { "ec_number": "2.7.7.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ0" } ] } ] }, { "uniprot_ac": "Q2YDJ9", "gene_name": "GMPPB", "activity": [ { "ec_number": "2.7.7.13", "activity": "alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate.", "evidence": [ { "id": "Q2YDJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9" } ] }, { "ec_number": "2.7.7.13", "activity": "", "evidence": [ { "id": "Q2YDJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDJ9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 360, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDJ9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDJ9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q2YDJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9#function" }, { "id": "Q2YDJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9" } ], "binding_site_uniprot": 110, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 110, "end_pos": 110, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q2YDJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9#function" }, { "id": "Q2YDJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDJ9" } ], "binding_site_uniprot": 218, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 218, "end_pos": 218, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.7.13", "ec_name": "alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate.", "evidence": [ { "id": "2.7.7.13", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.13" }, { "id": "2.7.7.13", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.7.13" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 265, "end_pos": 267 }, { "start_pos": 271, "end_pos": 273 }, { "start_pos": 322, "end_pos": 324 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDL5-1", "uniprot_ac": "Q2YDL5", "uniprot_id": "FKB11_BOVIN", "mass": { "chemical_mass": 22475.0, "monoisotopic_mass": 22475.0 }, "refseq": { "ac": "NP_001039397", "name": "peptidyl-prolyl cis-trans isomerase FKBP11 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039397" }, "gene_names": [ { "name": "FKBP11", "type": "recommended", "evidence": [ { "id": "Q2YDL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5" } ] }, { "name": "FKBP-11", "type": "synonym", "evidence": [ { "id": "NP_001039397", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039397" } ] }, { "name": "FKBP11", "type": "synonym", "evidence": [ { "id": "NP_001039397", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039397" } ] } ], "protein_names": [ { "name": "Peptidyl-prolyl cis-trans isomerase FKBP11", "type": "recommended", "evidence": [ { "id": "Q2YDL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5/entry#names_and_taxonomy" } ] }, { "name": "5.2.1.8", "type": "synonym", "evidence": [ { "id": "Q2YDL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5/entry#names_and_taxonomy" } ] }, { "name": "FK506 binding protein 11, 19 kDa", "type": "synonym", "evidence": [ { "id": "NP_001039397", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039397" } ] }, { "name": "FK506-binding protein 11", "type": "synonym", "evidence": [ { "id": "NP_001039397", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039397" }, { "id": "Q2YDL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5/entry#names_and_taxonomy" } ] }, { "name": "FKBP-11", "type": "synonym", "evidence": [ { "id": "Q2YDL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5/entry#names_and_taxonomy" } ] }, { "name": "PPIase FKBP11", "type": "synonym", "evidence": [ { "id": "NP_001039397", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039397" }, { "id": "Q2YDL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5/entry#names_and_taxonomy" } ] }, { "name": "Rotamase", "type": "synonym", "evidence": [ { "id": "Q2YDL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5/entry#names_and_taxonomy" } ] }, { "name": "peptidyl-prolyl cis-trans isomerase FKBP11 precursor", "type": "synonym", "evidence": [ { "id": "NP_001039397", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039397" } ] }, { "name": "peptidyl-prolyl cis-trans isomerase FKBP11", "type": "synonym", "evidence": [ { "id": "NP_001039397", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039397" } ] }, { "name": "rotamase", "type": "synonym", "evidence": [ { "id": "NP_001039397", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039397" } ] } ], "function": [ { "annotation": "PPIases accelerate the folding of proteins during protein synthesis.", "evidence": [ { "database": "UniProtKB", "id": "Q2YDL5", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDL5", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FKBP11", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5", "locus": { "chromosome": "5", "start_pos": 30884834, "end_pos": 30881374, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015828", "url": "https://www.ensembl.org/id/ENSBTAG00000015828" } ] } } ], "crossref": [ { "id": "Q2YDL5", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDL5", "database": "AlphaFoldDB", "categories": [] }, { "id": "506043", "url": "https://www.ncbi.nlm.nih.gov/gene/506043", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044609", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044609", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506043", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506043", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDL5", "url": "https://www.orthodb.org/?gene=Q2YDL5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45779", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45779", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45779:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45779:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00254", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00254", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039397", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16237", "url": "https://www.rhea-db.org/rhea/16237", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDL5", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDL5-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTLRPSLLPLRLLLLLLLLLRGAVCQAEAGSETESPVRTLQVETLVEPPEPCAEPATFGDTLHIHYSGSLVDGRIFDTSLTRDPLVIELGQKQVIPGLEQSLLDMCVGEKRRVIIPSHLAYGKRGFPPSIPADAELHFDVELIALIRANYWQKLVKGILPLVGMAMVPALLGLIGYHLYRKASSPKISKNKLKEEKRNKSKKK", "length": 203, "header": "sp|Q2YDL5-1|FKB11_BOVIN Isoform 1 of Peptidyl-prolyl cis-trans isomerase FKBP11 OS=Bos taurus OX=9913 GN=FKBP11 PE=2 SV=1 CANONICAL=Q2YDL5-1" }, "isoforms": [ { "isoform_ac": "Q2YDL5-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5/entry#Q2YDL5-1", "sequence": { "sequence": "MTLRPSLLPLRLLLLLLLLLRGAVCQAEAGSETESPVRTLQVETLVEPPEPCAEPATFGDTLHIHYSGSLVDGRIFDTSLTRDPLVIELGQKQVIPGLEQSLLDMCVGEKRRVIIPSHLAYGKRGFPPSIPADAELHFDVELIALIRANYWQKLVKGILPLVGMAMVPALLGLIGYHLYRKASSPKISKNKLKEEKRNKSKKK", "length": 203, "header": "sp|Q2YDL5-1|FKB11_BOVIN Isoform 1 of Peptidyl-prolyl cis-trans isomerase FKBP11 OS=Bos taurus OX=9913 GN=FKBP11 PE=2 SV=1 CANONICAL=Q2YDL5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:506043", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506043", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q2YDL5", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2YDL5", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "peptidyl-prolyl cis-trans isomerase activity", "id": "GO:0003755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003755", "evidence": [ { "database": "UniProtKB", "id": "Q2YDL5", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16237", "name": "", "equation": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M4A4-1", "P18203-1", "Q5BIN5-1", "A6QPY8-1", "F1N4S5-1", "F1N6W2-1", "G3X8B1-1", "A0A3Q1LI03-1", "A0AAA9TG77-1", "F1MNW5-1", "E1B9G4-1", "G3MXV0-1", "Q2KJC8-1", "A0AAF6YJC8-1", "A0AAF6YJR2-1", "P26882-1", "F6RD06-1", "Q32PA9-1", "Q0P5D0-1", "Q2KJ44-1", "Q2HJ89-1", "Q08E11-1", "Q9TRY0-1", "A0A3Q1LK42-1", "A4FV72-1", "P26884-1", "P30404-1", "P62935-1", "P68107-1", "Q29RZ2-1", "P80311-1", "A0AAA9RV00-1", "F1MU79-1", "A0A3Q1LJJ1-1", "Q5E992-1", "Q2YDL5-1", "A0AAA9U018-1", "A0ABI0NKM5-1", "A0ABI0NMT7-1", "A0A3Q1LSB7-1" ], "evidence": [ { "id": "16237", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16237" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LI03", "gene_name": "FKBP11", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A3Q1LI03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI03" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A3Q1LI03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI03" } ] } ] }, { "uniprot_ac": "A0A3Q1LJJ1", "gene_name": "", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A3Q1LJJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJJ1" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A3Q1LJJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJJ1" } ] } ] }, { "uniprot_ac": "A0A3Q1LK42", "gene_name": "FKBP8", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A3Q1LK42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LK42" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A3Q1LK42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LK42" } ] } ] }, { "uniprot_ac": "A0A3Q1LSB7", "gene_name": "LOC786614", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A3Q1LSB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSB7" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A3Q1LSB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSB7" } ] } ] }, { "uniprot_ac": "A0A3Q1M4A4", "gene_name": "LOC112445968", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A3Q1M4A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4A4" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A3Q1M4A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4A4" } ] } ] }, { "uniprot_ac": "A0AAA9RV00", "gene_name": "PPIE", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0AAA9RV00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV00" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0AAA9RV00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV00" } ] } ] }, { "uniprot_ac": "A0AAA9TG77", "gene_name": "FKBP15", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0AAA9TG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG77" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0AAA9TG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG77" } ] } ] }, { "uniprot_ac": "A0AAA9U018", "gene_name": "AIP", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0AAA9U018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U018" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0AAA9U018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U018" } ] } ] }, { "uniprot_ac": "A0AAF6YJC8", "gene_name": "FKBP6", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0AAF6YJC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJC8" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0AAF6YJC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJC8" } ] } ] }, { "uniprot_ac": "A0AAF6YJR2", "gene_name": "FKBP3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0AAF6YJR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJR2" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0AAF6YJR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJR2" } ] } ] }, { "uniprot_ac": "A0ABI0NKM5", "gene_name": "", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0ABI0NKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKM5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0ABI0NKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKM5" } ] } ] }, { "uniprot_ac": "A0ABI0NMT7", "gene_name": "", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0ABI0NMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT7" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0ABI0NMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT7" } ] } ] }, { "uniprot_ac": "A4FV72", "gene_name": "PPIE", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A4FV72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV72" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A4FV72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV72" } ] } ] }, { "uniprot_ac": "A6QPY8", "gene_name": "PIN4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A6QPY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QPY8" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A6QPY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QPY8" } ] } ] }, { "uniprot_ac": "E1B9G4", "gene_name": "PPIL3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "E1B9G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9G4" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "E1B9G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9G4" } ] } ] }, { "uniprot_ac": "F1MNW5", "gene_name": "", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F1MNW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNW5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F1MNW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNW5" } ] } ] }, { "uniprot_ac": "F1MU79", "gene_name": "FKBP4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F1MU79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU79" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F1MU79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU79" } ] } ] }, { "uniprot_ac": "F1N4S5", "gene_name": "FKBP14", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F1N4S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F1N4S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N4S5" } ] } ] }, { "uniprot_ac": "F1N6W2", "gene_name": "PPIL4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F1N6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6W2" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F1N6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6W2" } ] } ] }, { "uniprot_ac": "F6RD06", "gene_name": "FKBP7", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F6RD06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD06" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F6RD06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD06" } ] } ] }, { "uniprot_ac": "G3MXV0", "gene_name": "FKBP5", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "G3MXV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXV0" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "G3MXV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXV0" } ] } ] }, { "uniprot_ac": "G3X8B1", "gene_name": "LOC613401", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "G3X8B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X8B1" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "G3X8B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X8B1" } ] } ] }, { "uniprot_ac": "P18203", "gene_name": "FKBP1A", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P18203", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P18203" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P18203", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P18203" } ] } ] }, { "uniprot_ac": "P26882", "gene_name": "PPID", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P26882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26882" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P26882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26882" } ] } ] }, { "uniprot_ac": "P26884", "gene_name": "FKBP3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P26884", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26884" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P26884", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P26884" } ] } ] }, { "uniprot_ac": "P30404", "gene_name": "PPIF", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P30404" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P30404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P30404" } ] } ] }, { "uniprot_ac": "P62935", "gene_name": "PPIA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P62935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62935" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P62935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62935" } ] } ] }, { "uniprot_ac": "P68107", "gene_name": "FKBP1B", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P68107", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68107" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P68107", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68107" } ] } ] }, { "uniprot_ac": "P80311", "gene_name": "PPIB", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P80311", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80311" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P80311", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80311" } ] } ] }, { "uniprot_ac": "Q08E11", "gene_name": "PPIC", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q08E11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E11" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q08E11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E11" } ] } ] }, { "uniprot_ac": "Q0P5D0", "gene_name": "PPIH", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q0P5D0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5D0" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q0P5D0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5D0" } ] } ] }, { "uniprot_ac": "Q29RZ2", "gene_name": "PPWD1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q29RZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ2" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q29RZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ2" } ] } ] }, { "uniprot_ac": "Q2HJ89", "gene_name": "FKBP10", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q2HJ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ89" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q2HJ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ89" } ] } ] }, { "uniprot_ac": "Q2KJ44", "gene_name": "PTPA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q2KJ44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ44" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q2KJ44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ44" } ] } ] }, { "uniprot_ac": "Q2KJC8", "gene_name": "FKBP9", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q2KJC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJC8" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q2KJC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJC8" } ] } ] }, { "uniprot_ac": "Q2YDL5", "gene_name": "FKBP11", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q2YDL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q2YDL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5" } ] } ] }, { "uniprot_ac": "Q32PA9", "gene_name": "FKBP2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q32PA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q32PA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA9" } ] } ] }, { "uniprot_ac": "Q5BIN5", "gene_name": "PIN1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q5BIN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIN5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q5BIN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIN5" } ] } ] }, { "uniprot_ac": "Q5E992", "gene_name": "PPIL1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q5E992", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E992" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q5E992", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E992" } ] } ] }, { "uniprot_ac": "Q9TRY0", "gene_name": "FKBP4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q9TRY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TRY0" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q9TRY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TRY0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDL5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 203, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDL5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDL5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q2YDL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDL5" }, { "id": "PRU00277", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00277" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PPIase FKBP-type", "eco_id": "ECO_0000255", "start_pos": 59, "end_pos": 146, "start_aa": "Gly", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "5.2.1.8", "ec_name": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "5.2.1.8", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8" }, { "id": "5.2.1.8", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=5.2.1.8" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 198, "end_pos": 200 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDM7-1", "uniprot_ac": "Q2YDM7", "uniprot_id": "LSG1_BOVIN", "mass": { "chemical_mass": 74249.0, "monoisotopic_mass": 74249.0 }, "refseq": { "ac": "NP_001039375", "name": "large subunit GTPase 1 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039375" }, "gene_names": [ { "name": "LSG1", "type": "recommended", "evidence": [ { "id": "Q2YDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ] }, { "name": "LSG1", "type": "synonym", "evidence": [ { "id": "NP_001039375", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039375" } ] } ], "protein_names": [ { "name": "Large subunit GTPase 1 homolog", "type": "recommended", "evidence": [ { "id": "Q2YDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7/entry#names_and_taxonomy" } ] }, { "name": "3.6.5.-", "type": "synonym", "evidence": [ { "id": "Q2YDM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7/entry#names_and_taxonomy" } ] }, { "name": "large subunit GTPase 1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001039375", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039375" } ] } ], "function": [ { "annotation": "Functions as a GTPase. May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation.", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM7", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7#function" }, { "database": "UniProtKB", "id": "Q9H089", "url": "https://www.uniprot.org/uniprotkb/Q9H089#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDM7", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LSG1", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7", "locus": { "chromosome": "1", "start_pos": 72900012, "end_pos": 72877436, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008461", "url": "https://www.ensembl.org/id/ENSBTAG00000008461" } ] } } ], "crossref": [ { "id": "Q2YDM7", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDM7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01857", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01857", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505082", "url": "https://www.ncbi.nlm.nih.gov/gene/505082", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043358", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043358", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505082", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505082", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDM7", "url": "https://www.orthodb.org/?gene=Q2YDM7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45709", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45709", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45709:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45709:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01926", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01926", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039375", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDM7", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDM7-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRRRAPEGGTLGRALIRQQVQRSRSHRHTDSWLHTSELNDGYDWGRLNLQSVTEQSSLDDFLATAELAGTEFVAEKLNIKFVPPEARTGLLSFEENQRIKKLHEENKQFLCIPRRPKWDQKTSPEELKQAEKDNFLEWRRQLVWLEEEQNLILTPFERNLDFWRQLWRVIERSDIVVQIVDARNPLLFRCEDLECYVKTIDDNKENVILINKADLLTAEQRSAWAEFFKKENVKVIFWSALAEAIKLMGNSKGDVNGDTGEAITAEFENSSCDEAEILHKETEHLSLGEAASSEEDESEYEDCQEEEEDWQTCLEDSSSSDEEACGQDCKEGHTVDSEAQGRNTPQKRQIHNFSHLVSKQELLEVFKQLHSGKKVKDGQLTVGLVGYPNVGKSSTINTILGNKKVSVSATPGHTKHFQTLYVEPGLCLCDCPGLVMPSFVSTKAEMICSGILPIDQMRDHVPPVSLVCQNIPRHVLEATYGIDIIKPREDEDPRRPPTSEELLTAYGCMRGFMTAHGQPDQPRSARYILKDYVNGKLLYCHPPPGRDPVTFQYQHQRLLEKKVNGGEIKLQVVRNKKVYQIENVVDKAFFHQENVRALTKGVQAVMGYKPGSGLVTAAAVSSERGAGKPWKKHGNRNKKEKSRRLYKHLDM", "length": 652, "header": "sp|Q2YDM7-1|LSG1_BOVIN Isoform 1 of Large subunit GTPase 1 homolog OS=Bos taurus OX=9913 GN=LSG1 PE=2 SV=1 CANONICAL=Q2YDM7-1" }, "isoforms": [ { "isoform_ac": "Q2YDM7-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7/entry#Q2YDM7-1", "sequence": { "sequence": "MGRRRAPEGGTLGRALIRQQVQRSRSHRHTDSWLHTSELNDGYDWGRLNLQSVTEQSSLDDFLATAELAGTEFVAEKLNIKFVPPEARTGLLSFEENQRIKKLHEENKQFLCIPRRPKWDQKTSPEELKQAEKDNFLEWRRQLVWLEEEQNLILTPFERNLDFWRQLWRVIERSDIVVQIVDARNPLLFRCEDLECYVKTIDDNKENVILINKADLLTAEQRSAWAEFFKKENVKVIFWSALAEAIKLMGNSKGDVNGDTGEAITAEFENSSCDEAEILHKETEHLSLGEAASSEEDESEYEDCQEEEEDWQTCLEDSSSSDEEACGQDCKEGHTVDSEAQGRNTPQKRQIHNFSHLVSKQELLEVFKQLHSGKKVKDGQLTVGLVGYPNVGKSSTINTILGNKKVSVSATPGHTKHFQTLYVEPGLCLCDCPGLVMPSFVSTKAEMICSGILPIDQMRDHVPPVSLVCQNIPRHVLEATYGIDIIKPREDEDPRRPPTSEELLTAYGCMRGFMTAHGQPDQPRSARYILKDYVNGKLLYCHPPPGRDPVTFQYQHQRLLEKKVNGGEIKLQVVRNKKVYQIENVVDKAFFHQENVRALTKGVQAVMGYKPGSGLVTAAAVSSERGAGKPWKKHGNRNKKEKSRRLYKHLDM", "length": 652, "header": "sp|Q2YDM7-1|LSG1_BOVIN Isoform 1 of Large subunit GTPase 1 homolog OS=Bos taurus OX=9913 GN=LSG1 PE=2 SV=1 CANONICAL=Q2YDM7-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 411, "start_aa": "Thr", "end_pos": 411, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr411", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 252, "end_pos": 252, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM7", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ], "site_lbl": "Ser252" }, { "start_pos": 93, "end_pos": 93, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM7", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ], "site_lbl": "Ser93" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:505082", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505082", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM7", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM7", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM7", "url": 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"https://www.uniprot.org/uniprotkb/Q2YDM7" } ], "pmid": "" }, { "name": "nuclear export", "id": "GO:0051168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051168", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM7", "url": "https://www.uniprot.org/uniprotkb/Q2YDM7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 270, "end_pos": 272, "annotation": "n_glycosylation_sequon" }, { "start_pos": 353, "end_pos": 355, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", 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"F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } 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phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": 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"ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SVR8", "gene_name": "LOC789148", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] } ] }, { "uniprot_ac": "A0AAA9T9T1", "gene_name": "ERAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] } ] }, { "uniprot_ac": "A0AAA9TES1", "gene_name": "RAB5C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES1" } ] } ] }, { "uniprot_ac": "A0AAA9TNQ2", 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"expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDM8", "url": "https://www.uniprot.org/uniprotkb/Q2YDM8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GLT6D1", "url": "https://www.uniprot.org/uniprotkb/Q2YDM8", "locus": { "chromosome": "11", "start_pos": 103271493, "end_pos": 103279630, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020249", "url": "https://www.ensembl.org/id/ENSBTAG00000020249" } ] } } ], "crossref": [ { "id": "Q2YDM8", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDM8", "database": "AlphaFoldDB", "categories": [] }, { "id": "529958", "url": "https://www.ncbi.nlm.nih.gov/gene/529958", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005076", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005076", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529958", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529958", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDM8", "url": "https://www.orthodb.org/?gene=Q2YDM8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10462", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10462", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10462:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10462:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03414", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03414", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069396", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069396", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q2YDM8", "url": "https://www.uniprot.org/uniprotkb/Q2YDM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q2YDM8-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDM8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNCKRKMLLLIQGLSLLLLFDHYSRKNQEEELELSDWFKPRGRPDVITTTSWLAPVVWEGTFSRKMLEKHYRRQNFTTGLAVFATGRLADPYLELFLNSANKYFLTGYRVIFYIMMDTFIKLPQIKWEPLRQFKVFIVTESRWWDNDVVRMKSLAKHIIWDIQGEVDFLFSMTVTQIFQNNVGVEVLGELVAQLHGWWYFKDRASFPYERRPKSAAYIPFGQGDFYYDGAFVGGTPQEVLNLAEEYLNGVIHDLGLRLNSSYEKHLNKYFFLRKPTKLLSPEYNWDADFYPPPQVQYVKVAQQSKRRH", "length": 308, "header": "sp|Q2YDM8-1|GL6D1_BOVIN Isoform 1 of Glycosyltransferase 6 domain-containing protein 1 OS=Bos taurus OX=9913 GN=GLT6D1 PE=2 SV=1 CANONICAL=Q2YDM8-1" }, "isoforms": [ { "isoform_ac": "Q2YDM8-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDM8/entry#Q2YDM8-1", "sequence": { "sequence": "MNCKRKMLLLIQGLSLLLLFDHYSRKNQEEELELSDWFKPRGRPDVITTTSWLAPVVWEGTFSRKMLEKHYRRQNFTTGLAVFATGRLADPYLELFLNSANKYFLTGYRVIFYIMMDTFIKLPQIKWEPLRQFKVFIVTESRWWDNDVVRMKSLAKHIIWDIQGEVDFLFSMTVTQIFQNNVGVEVLGELVAQLHGWWYFKDRASFPYERRPKSAAYIPFGQGDFYYDGAFVGGTPQEVLNLAEEYLNGVIHDLGLRLNSSYEKHLNKYFFLRKPTKLLSPEYNWDADFYPPPQVQYVKVAQQSKRRH", "length": 308, "header": "sp|Q2YDM8-1|GL6D1_BOVIN Isoform 1 of Glycosyltransferase 6 domain-containing protein 1 OS=Bos taurus OX=9913 GN=GLT6D1 PE=2 SV=1 CANONICAL=Q2YDM8-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 75, "start_aa": "Asn", "end_pos": 75, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn75", "evidence": [ { "id": "Q2YDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDM8#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycosyltransferase-activity", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:529958", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529958", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM8", "url": "https://www.uniprot.org/uniprotkb/Q2YDM8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM8", "url": "https://www.uniprot.org/uniprotkb/Q2YDM8" } ], "pmid": "" }, { "name": "vesicle", "id": "GO:0031982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031982", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM8", "url": "https://www.uniprot.org/uniprotkb/Q2YDM8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM8", "url": "https://www.uniprot.org/uniprotkb/Q2YDM8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "glycosyltransferase activity", "id": "GO:0016757", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016757", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM8", "url": "https://www.uniprot.org/uniprotkb/Q2YDM8" } ], "pmid": "" }, { "name": "hexosyltransferase activity", "id": "GO:0016758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016758", "evidence": [ { "database": "UniProtKB", "id": "Q2YDM8", "url": "https://www.uniprot.org/uniprotkb/Q2YDM8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 259, "end_pos": 261, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q2YDM8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 308, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q2YDM8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q2YDM8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 75 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 259, "end_pos": 261 }, { "start_pos": 75, "end_pos": 77 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q2YDN6-1", "uniprot_ac": "Q2YDN6", "uniprot_id": "RPF2_BOVIN", "mass": { "chemical_mass": 35543.0, "monoisotopic_mass": 35543.0 }, "refseq": { "ac": "NP_001039548", "name": "ribosome production factor 2 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039548" }, "gene_names": [ { "name": "RPF2", "type": "recommended", "evidence": [ { "id": "Q2YDN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN6" } ] }, { "name": "BXDC1", "type": "synonym", "evidence": [ { "id": "NP_001039548", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039548" }, { "id": "Q2YDN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN6" } ] }, { "name": "RPF2", "type": "synonym", "evidence": [ { "id": "NP_001039548", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039548" } ] } ], "protein_names": [ { "name": "Ribosome production factor 2 homolog", "type": "recommended", "evidence": [ { "id": "Q2YDN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN6/entry#names_and_taxonomy" } ] }, { "name": "Brix domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "Q2YDN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN6/entry#names_and_taxonomy" } ] }, { "name": "Ribosome biogenesis protein RPF2 homolog", "type": "synonym", "evidence": [ { "id": "Q2YDN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN6/entry#names_and_taxonomy" } ] }, { "name": "brix domain containing 1", "type": "synonym", "evidence": [ { "id": "NP_001039548", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039548" } ] }, { "name": "brix domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001039548", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039548" } ] }, { "name": "ribosome biogenesis protein RPF2 homolog", "type": "synonym", "evidence": [ { "id": "NP_001039548", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039548" } ] }, { "name": "ribosome production factor 2 homolog", "type": "synonym", "evidence": [ { "id": "NP_001039548", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039548" } ] } ], "function": [ { "annotation": "Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.", "evidence": [ { "database": "UniProtKB", "id": "Q2YDN6", "url": "https://www.uniprot.org/uniprotkb/Q2YDN6#function" }, { "database": "UniProtKB", "id": "Q9H7B2", "url": "https://www.uniprot.org/uniprotkb/Q9H7B2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q2YDN6", "url": "https://www.uniprot.org/uniprotkb/Q2YDN6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPF2", "url": "https://www.uniprot.org/uniprotkb/Q2YDN6", "locus": { "chromosome": "9", "start_pos": 39325007, "end_pos": 39367065, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016584", "url": "https://www.ensembl.org/id/ENSBTAG00000016584" } ] } } ], "crossref": [ { "id": "Q2YDN6", "url": "https://alphafold.ebi.ac.uk/entry/Q2YDN6", "database": "AlphaFoldDB", "categories": [] }, { "id": "511294", "url": "https://www.ncbi.nlm.nih.gov/gene/511294", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511294", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511294", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q2YDN6", "url": "https://www.orthodb.org/?gene=Q2YDN6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12728", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12728", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { 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"MDALDRVVKPKTKRAKRFLEKREPKLSENIKNAMLIKGGNANSTVTQVLRDVYALKKPYGILYKKKNITRPFEDQTSLEFFSKKSDCSLFMFGSHNKKRPNNLVIGRMYDYHVLDIIELGIEKFVSLKDIKNSKCPEGTKPMLIFAGDDFDVTEDYRRLKSLLIDFFRGPTVSNIRLAGLEYVLHFTALNGKIYFRSYKLLLKKSGCRTPRIELEEMGPSLDLVLRRTHLASDDLYKLSMKMPKALKPKKKKNISHDTFGTTYGRIHMQKQDLSKLQTRKMKGLKKRPAERKAEDEENKSKRIKKN", "length": 306, "header": "sp|Q2YDN6-1|RPF2_BOVIN Isoform 1 of Ribosome production factor 2 homolog OS=Bos taurus OX=9913 GN=RPF2 PE=2 SV=1 CANONICAL=Q2YDN6-1" }, "isoforms": [ { "isoform_ac": "Q2YDN6-1", "url": "https://www.uniprot.org/uniprotkb/Q2YDN6/entry#Q2YDN6-1", "sequence": { "sequence": "MDALDRVVKPKTKRAKRFLEKREPKLSENIKNAMLIKGGNANSTVTQVLRDVYALKKPYGILYKKKNITRPFEDQTSLEFFSKKSDCSLFMFGSHNKKRPNNLVIGRMYDYHVLDIIELGIEKFVSLKDIKNSKCPEGTKPMLIFAGDDFDVTEDYRRLKSLLIDFFRGPTVSNIRLAGLEYVLHFTALNGKIYFRSYKLLLKKSGCRTPRIELEEMGPSLDLVLRRTHLASDDLYKLSMKMPKALKPKKKKNISHDTFGTTYGRIHMQKQDLSKLQTRKMKGLKKRPAERKAEDEENKSKRIKKN", "length": 306, "header": "sp|Q2YDN6-1|RPF2_BOVIN Isoform 1 of Ribosome production factor 2 homolog OS=Bos taurus OX=9913 GN=RPF2 PE=2 SV=1 CANONICAL=Q2YDN6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511294", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511294", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "protein localization to nucleolus", "id": "GO:1902570", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902570", "evidence": [ { "database": "UniProtKB", "id": "Q2YDN6", "url": "https://www.uniprot.org/uniprotkb/Q2YDN6" } ], "pmid": "" }, { "name": "ribosomal large subunit biogenesis", "id": "GO:0042273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042273", "evidence": [ { "database": "UniProtKB", "id": "Q2YDN6", "url": "https://www.uniprot.org/uniprotkb/Q2YDN6" } ], "pmid": "" }, { "name": "regulation of signal transduction by p53 class mediator", "id": "GO:1901796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901796", "evidence": [ { "database": "UniProtKB", "id": "Q2YDN6", "url": "https://www.uniprot.org/uniprotkb/Q2YDN6" } ], "pmid": "" }, { "name": "ribosomal large subunit assembly", "id": "GO:0000027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000027", "evidence": [ { "database": "UniProtKB", "id": "Q2YDN6", "url": "https://www.uniprot.org/uniprotkb/Q2YDN6" } ], "pmid": "" }, { "name": "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "id": "GO:0000463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000463", "evidence": [ { "database": "UniProtKB", "id": "Q2YDN6", "url": "https://www.uniprot.org/uniprotkb/Q2YDN6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q2YDN6", "url": 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"https://www.uniprot.org/uniprotkb/Q32KL2/entry#Q32KL2-1", "sequence": { "sequence": "MALASVLERPLSVNRRGFFGLGGRADLLDLGPGSPSDGLSLAAPSWGVPEEPRIEILHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEEAYDLARRAIYQATYRDAYSGGSVSLYHVREDGWIRVSSDNVADLHDKYSGSTH", "length": 263, "header": "sp|Q32KL2-1|PSB5_BOVIN Isoform 1 of Proteasome subunit beta type-5 OS=Bos taurus OX=9913 GN=PSMB5 PE=1 SV=1 CANONICAL=Q32KL2-1" }, "locus": { "chromosome": "10", "start_pos": 21826801, "end_pos": 21821860, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016918.4", "url": "https://www.ensembl.org/id/ENSBTAT00000016918.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016918.2", "url": "https://www.ensembl.org/id/ENSBTAP00000016918.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": 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"MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP", "length": 263 }, "evidence": [ { "id": "Q32KL2", "url": "https://omabrowser.org/oma/group/Q32KL2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P28075-1", "protein_name": "Proteasome subunit beta type-5", "gene_name": "Psmb5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALASVLQRPMPVNQHGFFGLGGRADLLDLGPGSPGDGLSLAAPSWGVPEEPRIEMLHGTTTLAFKFQHGVIVAADSRATAGPYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGTAFSVGSGSVYAFGVMDRGYSYDLQVEEAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHDKYTSSIP", "length": 263 }, "evidence": [ { "id": "Q32KL2", "url": "https://omabrowser.org/oma/group/Q32KL2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P30656-1", "protein_name": "Proteasome subunit beta type-5", "gene_name": "PRE2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MQAIADSFSVPNRLVKELQYDNEQNLESDFVTGASQFQRLAPSLTVPPIASPQQFLRAHTDDSRNPDCKIKIAHGTTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG", "length": 287 }, "evidence": [ { "id": "Q32KL2", "url": "https://omabrowser.org/oma/group/Q32KL2/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54BC8-1", "protein_name": "Proteasome subunit beta type-5", "gene_name": "psmB5", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MINIDFDNIEQSQPTLYDTLASDVKFLNTPHFELPPNANPGDFLRETFDHPSAPKALEFAHGTTTLAFVYGGGIIVSVDSKSTQGPYVASRSVKKVIEITPTLLGTMAGGAADCSFWERELGRRCRLYELRNKELISVAAASKILANIVYSYKGYGLSMGTMITGWDKTGPQLYYVDNDGTRLHGQRFSCGSGSTYAYGVLDTGFKWDMNDEEAYELGRRAVYHATHRDAYSGGAINVYHVQKDGWKKISSDDCFKLYQKYYNIVPINKPAN", "length": 272 }, "evidence": [ { "id": "Q32KL2", "url": "https://omabrowser.org/oma/group/Q32KL2/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "proteasome core complex, beta-subunit complex", "id": "GO:0019774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019774", "evidence": [ { "database": "UniProtKB", "id": "Q32KL2", "url": "https://www.uniprot.org/uniprotkb/Q32KL2" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32KL2", "url": "https://www.uniprot.org/uniprotkb/Q32KL2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q32KL2", "url": "https://www.uniprot.org/uniprotkb/Q32KL2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q32KL2", "url": "https://www.uniprot.org/uniprotkb/Q32KL2" } ], "pmid": "" }, { "name": "proteasome core complex", "id": "GO:0005839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005839", "evidence": [ { "database": "UniProtKB", "id": "Q32KL2", "url": "https://www.uniprot.org/uniprotkb/Q32KL2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32KL2", "url": "https://www.uniprot.org/uniprotkb/Q32KL2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "endopeptidase activity", "id": "GO:0004175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004175", "evidence": [ { "database": "UniProtKB", "id": "Q32KL2", "url": "https://www.uniprot.org/uniprotkb/Q32KL2" } ], "pmid": "" }, { "name": "threonine-type endopeptidase activity", "id": "GO:0004298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004298", "evidence": [ { "database": "UniProtKB", "id": "Q32KL2", "url": "https://www.uniprot.org/uniprotkb/Q32KL2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "Q32KL2", "url": "https://www.uniprot.org/uniprotkb/Q32KL2" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q32KL2", "url": "https://www.uniprot.org/uniprotkb/Q32KL2" } ], "pmid": "" }, { "name": "regulation of proteasomal protein catabolic process", "id": "GO:0061136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061136", "evidence": [ { "database": "UniProtKB", "id": "Q32KL2", "url": "https://www.uniprot.org/uniprotkb/Q32KL2" } ], "pmid": "" }, { "name": "proteolysis involved in protein catabolic process", "id": "GO:0051603", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051603", "evidence": [ { "database": "UniProtKB", "id": "Q32KL2", "url": "https://www.uniprot.org/uniprotkb/Q32KL2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-1168640", "name": "Ubiquitinated IkB is degraded", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-1168640", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1168640" } ] }, { "id": "R-BTA-1234159", "name": "Proteasome proteolyzes ub-HIF-alpha", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M2B6-1", "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-1234159", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1234159" } ] }, { "id": "R-BTA-1236970", "name": "Proteasomal clevage of exogenous antigen (26S proteasome catalyst)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-983036", "R-ALL-8942986" ], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-1236970", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1236970" } ] }, { "id": "R-BTA-1504193", "name": "Ubiquitinated DVL is degraded by the proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-1504193", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1504193" } ] }, { "id": "R-BTA-174058", "name": "Degradation of multiubiquitinated Cdh1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q32PA5-1", "Q2TA10-1", "Q3MHN0-1", "Q1RML1-1", "A0A3Q1MAR8-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-174058", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174058" } ] }, { "id": "R-BTA-174105", "name": "Degradation of multiubiquitinated cell cycle proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q32PA5-1", "Q2TA10-1", "Q3MHN0-1", "Q1RML1-1", "Q2TA06-1", "Q2TA25-1", "A0A3Q1MAR8-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-174105", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174105" } ] }, { "id": "R-BTA-174202", "name": "Degradation of multiubiquitinated Securin", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q32PA5-1", "Q2TA10-1", "Q3MHN0-1", "Q1RML1-1", "A0A3Q1MAR8-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-174202", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174202" } ] }, { "id": "R-BTA-174255", "name": "Degradation multiubiquitinated Cyclin A", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q32PA5-1", "Q2TA10-1", "Q3MHN0-1", "P48734-1", "Q1RML1-1", "F1MWP1-1", "A0A3Q1MAR8-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-174255", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174255" } ] }, { "id": "R-BTA-187574", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9Y0-1", "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-187574", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-187574" } ] }, { "id": "R-BTA-188191", "name": "APC/C:Cdh1-mediated degradation of Skp2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q32PA5-1", "Q2TA10-1", "Q3MHN0-1", "Q1RML1-1", "A0A3Q1MAR8-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-188191", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-188191" } ] }, { "id": "R-BTA-209061", "name": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-209061", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-209061" } ] }, { "id": "R-BTA-2130282", "name": "Degradation of ubiquitinated beta catenin by the proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P67774-1", "Q0P594-1", "A0A3Q1NDU7-1", "Q3MHN0-1", "P67827-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-2130282", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2130282" } ] }, { "id": "R-BTA-264458", "name": "Proteasome mediated degradation of COP1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-264458", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-264458" } ] }, { "id": "R-BTA-353125", "name": "26S proteosome degrades ODC holoenzyme complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "P27117-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-353125", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-353125" } ] }, { "id": "R-BTA-3640874", "name": "Ub-RibC-AXIN is degraded by the proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1B8R5-1", "Q3MHN0-1", "E1BMY0-1", "Q3T139-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-3640874", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3640874" } ] }, { "id": "R-BTA-450466", "name": "AUF1:mRNA complex is degraded", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-450466", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450466" } ] }, { "id": "R-BTA-4608855", "name": "PRICKLE1 is degraded by the proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-4608855", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4608855" } ] }, { "id": "R-BTA-4641256", "name": "Ubiquitinated AXIN is degraded by the proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "A0AAA9TWH7-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-4641256", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641256" } ] }, { "id": "R-BTA-4641260", "name": "Ubiquitinated DVL1 is degraded by the proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "F1N0L0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-4641260", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641260" } ] }, { "id": "R-BTA-5362448", "name": "Hh C-terminal fragments are degraded by the proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-5362448", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5362448" } ] }, { "id": "R-BTA-5607724", "name": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-5607724", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5607724" } ] }, { "id": "R-BTA-5607731", "name": "26S proteasome processes p-7S-p100:RELB to form p52:RELB", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-5607731", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5607731" } ] }, { "id": "R-BTA-5610754", "name": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-5610754", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5610754" } ] }, { "id": "R-BTA-5610758", "name": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-5610758", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5610758" } ] }, { "id": "R-BTA-5610760", "name": "GLI1 is degraded by the proteasome after ubiquitination by ITCH", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "A0AAA9RZ14-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-5610760", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5610760" } ] }, { "id": "R-BTA-5635854", "name": "GLI2,3 are degraded by the proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-5635854", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5635854" } ] }, { "id": "R-BTA-5635868", "name": "ub-GLI is degraded by the proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "A0AAA9RZ14-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-5635868", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5635868" } ] }, { "id": "R-BTA-5665854", "name": "ADRM1:26S proteaseome binds UCHL5", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q9XSJ0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-5665854", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5665854" } ] }, { "id": "R-BTA-5665871", "name": "ADRM1 binds 26S proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-5665871", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5665871" } ] }, { "id": "R-BTA-5668481", "name": "Protesomal degradation of K48polyUb-TRAF3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S7G8-1", "Q3MHN0-1", "E1BL08-1", "E1B9D9-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-5668481", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5668481" } ] }, { "id": "R-BTA-5668520", "name": "26Sproteasome degrades K48polyUb-NIK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "E1BL08-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-5668520", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5668520" } ] }, { "id": "R-BTA-5687112", "name": "MAPK6 is degraded by the 26S proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "G5E577-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-5687112", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5687112" } ] }, { "id": "R-BTA-5689539", "name": "ADRM1:26S proteaseome binds USP14", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0IIF7-1", "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-5689539", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689539" } ] }, { "id": "R-BTA-68825", "name": "Ubiquitinated geminin is degraded by the proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-68825", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68825" } ] }, { "id": "R-BTA-68948", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-68948", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68948" } ] }, { "id": "R-BTA-69016", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-69016", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69016" } ] }, { "id": "R-BTA-69600", "name": "Proteolytic degradation of ubiquitinated-Cdc25A", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A7MBD1-1", "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-69600", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69600" } ] }, { "id": "R-BTA-75825", "name": "Proteasome mediated degradation of Cyclin D1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-75825", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75825" } ] }, { "id": "R-BTA-8850992", "name": "Proteasome degrades polyubiquitinated PTEN", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "A0AAA9U0H6-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-8850992", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8850992" } ] }, { "id": "R-BTA-8852354", "name": "GTSE1 facilitates proteasome-mediated degradation of TP53", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-8852354", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8852354" } ] }, { "id": "R-BTA-8854044", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q2TA06-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-8854044", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854044" } ] }, { "id": "R-BTA-8854071", "name": "Proteasome-mediated degradation of PolyUb-FBXL7", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-8854071", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854071" } ] }, { "id": "R-BTA-8866553", "name": "misfolded CFTR is degraded by the 26S proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "F1MN01-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-8866553", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8866553" } ] }, { "id": "R-BTA-8932355", "name": "26S proteasome degrades Ub-NFE2L2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-8932355", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8932355" } ] }, { "id": "R-BTA-8939801", "name": "26S proteasome degrades PolyUb-RUNX2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-8939801", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8939801" } ] }, { "id": "R-BTA-8952408", "name": "Polyubiquitinated RUNX3 is degraded by the proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-8952408", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8952408" } ] }, { "id": "R-BTA-8956140", "name": "NEDD8 and UBD bind NUB1 and the 26S proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-8956140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8956140" } ] }, { "id": "R-BTA-8956184", "name": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-8956184", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8956184" } ] }, { "id": "R-BTA-8957265", "name": "26S proteasome degrades TP73 polyubiquitinated by ITCH", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-8957265", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957265" } ] }, { "id": "R-BTA-9755303", "name": "26S proteasome degrades HIFalpha", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-9755303", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9755303" } ] }, { "id": "R-BTA-9755306", "name": "ub UBXN7 is degraded by the 26S proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-9755306", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9755306" } ] }, { "id": "R-BTA-9762096", "name": "Ub,pS335,S338,T NFE2L2 is degraded", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-9762096", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9762096" } ] }, { "id": "R-BTA-9766223", "name": "Proteasome-dependent degradation of ubiquitinated CDH1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, early endosome membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "A0A3Q1MF25-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-9766223", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9766223" } ] }, { "id": "R-BTA-983150", "name": "Proteasomal cleavage of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-983123" ], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-983150", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983150" } ] }, { "id": "R-BTA-9907898", "name": "Formation of the inner ring of the 20S core particle of the 26S proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-9907898", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9907898" } ] }, { "id": "R-BTA-9907919", "name": "Formation of the preholoproteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-9907919", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9907919" } ] }, { "id": "R-BTA-9908101", "name": "Maturation of the canonical 20S core particle", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-9908101", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9908101" } ] }, { "id": "R-BTA-9908709", "name": "Formation of the PA28-alpha-beta-20S proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-9908709", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9908709" } ] }, { "id": "R-BTA-9908721", "name": "Formation of the PA28gamma-20S proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-9908721", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9908721" } ] }, { "id": "R-BTA-9908786", "name": "Formation of bovine preholospermatoproteasome", "equation": "", "summary": "The 20S core particle of spermatoproteasome (20S sCP) can be purified from bovine testes, implying that two half-spermatoproteasomes join to form the preholospermatoproteasome that contains two inner and two outer rings (Zivkovic et al. 2022).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q2TBP0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-9908786", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9908786" } ] }, { "id": "R-BTA-9908803", "name": "Formation of bovine spermatoproteasome", "equation": "", "summary": "Based on a bovine study (Zivkovic et al. 2022), 19S is the predominant regulatory particle that is present in spermatoproteasomes (Zivkovic et al. 2022). A spermatoproteasome-specific proteasome activator PSME4 (PA200) is also a component of bovine spermatoproteasome (Zivkovic et al. 2022).", "cellular_location": "cytosol", "input_participant_list": [ "R-BTA-9909078" ], "output_participant_list": [ "R-BTA-9909073", "R-BTA-9909075", "R-BTA-9909082" ], "enzyme_list": [ "Q3MHN0-1", "Q2TBP0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-9908803", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9908803" } ] }, { "id": "R-BTA-9912636", "name": "Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-983035" ], "output_participant_list": [ "R-ALL-8955634" ], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-9912636", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9912636" } ] }, { "id": "R-BTA-9929352", "name": "Ubiquitinated CD274 is degraded by the 26S proteasome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-9929352", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9929352" } ] }, { "id": "R-BTA-9929486", "name": "SPOP-mediated degradation of CD274 by 26S Proteosome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-9929486", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9929486" } ] }, { "id": "R-BTA-9931314", "name": "Proteasomal degradation of polyUb-p-S195-CD274", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-9931314", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931314" } ] }, { "id": "R-BTA-9934893", "name": "Proteolysis of K48polyUb-K,p-S-PER1,2,3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-9934893", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9934893" } ] }, { "id": "R-BTA-9954728", "name": "The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-BTA-9954728", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954728" } ] }, { "id": "R-NUL-9908837", "name": "hPSMF1 binds bovine 20S core particle", "equation": "", "summary": "Human PSMF1 (PI31) binds to the bovine 20S core particle (20S CP) (McCutchen-Maloney et al. 2000: human PSMF1 and bovine 20S CP were used; Hsu et al. 2023: human PSMF1 and bovine 20S CP were used; Wang et al. 2024: human PSMF1 and bovine 20S CP were used).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHN0-1", "Q2TBP0-1", "Q32KL2-1" ], "evidence": [ { "id": "R-NUL-9908837", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-NUL-9908837" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-8942986", "participant_name": "L-amino acid [cytosol]", "crossref": [ { "id": "59869", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-8955634", "participant_name": "oligopeptide fragment (3-7aa) [cytosol]", "crossref": [ { "id": "25676", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-983035", "participant_name": "antigenic substrate [cytosol]", "crossref": [ { "id": "23367", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-983036", "participant_name": "precursor peptide fragment (>16 aa) [cytosol]", "crossref": [ { "id": "25676", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-983123", "participant_name": "K48polyUb-antigenic substrate [cytosol]", "crossref": [ { "id": "23367", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-BTA-9909073", "participant_name": "bPSMD5 [cytosol]", "crossref": [ { "id": "Q0P5A6", "database": "UniProt", "url": "" }, { "id": "NP_001069161.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-BTA-9909075", "participant_name": "bPSMD10 [cytosol]", "crossref": [ { "id": "ENSBTAG00000013721", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000018226", "database": "ENSEMBL", "url": "" }, { "id": "A0A3S5ZP61", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000018226", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-9909078", "participant_name": "bPSME4 [cytosol]", "crossref": [ { "id": "F1MKX4", "database": "UniProt", "url": "" }, { "id": "33476", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-9909082", "participant_name": "bPAAF1 [cytosol]", "crossref": [ { "id": "ENSBTAP00000105697", "database": "ENSEMBL", "url": "" }, { "id": "NP_001069458.1", "database": "RefSeq", "url": "" }, { "id": "Q148I1", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000003679", "database": "ENSEMBL", "url": "" }, { "id": "54890", "database": "VGNC", "url": "" }, { "id": "ENSBTAT00000147648", "database": "ENSEMBL", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M2B6", "gene_name": "EGLN1", "activity": [ { "ec_number": "1.14.11.29", "activity": "L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2.", "evidence": [ { "id": "A0A3Q1M2B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2B6" } ] }, { "ec_number": "1.14.11.29", "activity": "", "evidence": [ { "id": "A0A3Q1M2B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2B6" } ] } ] }, { "uniprot_ac": "A0A3Q1MAR8", "gene_name": "UBE2E1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] } ] }, { "uniprot_ac": "A0A3Q1MF25", "gene_name": "MDM2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1MF25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF25" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1MF25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF25" } ] } ] }, { "uniprot_ac": "A0A3Q1NDU7", "gene_name": "GSK3B", "activity": [ { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NDU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDU7" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0A3Q1NDU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDU7" } ] } ] }, { "uniprot_ac": "A0AAA9RZ14", "gene_name": "ITCH", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] } ] }, { "uniprot_ac": "A0AAA9S7G8", "gene_name": "TRAF3", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9S7G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9S7G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7G8" } ] } ] }, { "uniprot_ac": "A0AAA9TWH7", "gene_name": "SMURF2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] } ] }, { "uniprot_ac": "A0AAA9U0H6", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] } ] }, { "uniprot_ac": "A7MBD1", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] } ] }, { "uniprot_ac": "E1B8R5", "gene_name": "TNKS", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "E1B8R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R5" } ] } ] }, { "uniprot_ac": "E1B9D9", "gene_name": "TRAF2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B9D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9D9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B9D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9D9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BMY0", "gene_name": "TNKS2", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "E1BMY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMY0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1N0L0", "gene_name": "HECW1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N0L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N0L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0L0" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "P27117", "gene_name": "ODC1", "activity": [ { "ec_number": "4.1.1.17", "activity": "L-ornithine + H(+) = putrescine + CO2.", "evidence": [ { "id": "P27117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P27117" } ] }, { "ec_number": "4.1.1.17", "activity": "", "evidence": [ { "id": "P27117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P27117" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P67774", "gene_name": "PPP2CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "Q0IIF7", "gene_name": "USP14", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "Q0IIF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIF7" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "Q0IIF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIF7" } ] } ] }, { "uniprot_ac": "Q0P594", "gene_name": "PPP2CB", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] } ] }, { "uniprot_ac": "Q1RML1", "gene_name": "UBE2S", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA10", "gene_name": "UBE2D1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBP0", "gene_name": "PSMB7", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "Q2TBP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "Q2TBP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP0" } ] } ] }, { "uniprot_ac": "Q32KL2", "gene_name": "PSMB5", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "Q32KL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL2" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "Q32KL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KL2" } ] } ] }, { "uniprot_ac": "Q32PA5", "gene_name": "UBE2C", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] } ] }, { "uniprot_ac": "Q3MHN0", "gene_name": "PSMB6", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "Q3MHN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHN0" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "Q3MHN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHN0" } ] } ] }, { "uniprot_ac": "Q3T139", "gene_name": "RNF146B", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3T139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T139" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q3T139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T139" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q9XSJ0", "gene_name": "UCHL5", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "Q9XSJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSJ0" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": 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"esophageal cancer related gene 4 protein", "type": "synonym", "evidence": [ { "id": "NP_001033202", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033202" } ] } ], "function": [ { "annotation": "Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (By similarity). 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"https://www.ensembl.org/id/ENSBTAG00000012637" } ] } } ], "crossref": [ { "id": "Q32KM8", "url": "https://alphafold.ebi.ac.uk/entry/Q32KM8", "database": "AlphaFoldDB", "categories": [] }, { "id": "515133", "url": "https://www.ncbi.nlm.nih.gov/gene/515133", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028173", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028173", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515133", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515133", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32KM8", "url": "https://www.orthodb.org/?gene=Q32KM8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31613", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31613", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31613:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31613:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15187", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15187", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033202", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KM8", "url": "https://www.uniprot.org/uniprotkb/Q32KM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KM8-1", "url": "https://www.uniprot.org/uniprotkb/Q32KM8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANSSARPAFLVMTALALLLLLCVGPGGISGNKLKLLLRKREAPAPTMTPVAVQESRAKEFLSSLRRPKRQLWDRSRPEVQQWYQHFLYLGFDEAKFEDDISYWLNRNRNGHDYYDYYQRHYDEDSAIGPRSAHSFRHGASVNYDDY", "length": 147, "header": "sp|Q32KM8-1|AUGN_BOVIN Isoform 1 of Augurin OS=Bos taurus OX=9913 GN=ECRG4 PE=2 SV=1 CANONICAL=Q32KM8-1" }, "isoforms": [ { "isoform_ac": "Q32KM8-1", "url": "https://www.uniprot.org/uniprotkb/Q32KM8/entry#Q32KM8-1", "sequence": { "sequence": "MANSSARPAFLVMTALALLLLLCVGPGGISGNKLKLLLRKREAPAPTMTPVAVQESRAKEFLSSLRRPKRQLWDRSRPEVQQWYQHFLYLGFDEAKFEDDISYWLNRNRNGHDYYDYYQRHYDEDSAIGPRSAHSFRHGASVNYDDY", "length": 147, "header": "sp|Q32KM8-1|AUGN_BOVIN Isoform 1 of Augurin OS=Bos taurus OX=9913 GN=ECRG4 PE=2 SV=1 CANONICAL=Q32KM8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515133", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515133", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q32KM8", "url": "https://www.uniprot.org/uniprotkb/Q32KM8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32KM8", "url": "https://www.uniprot.org/uniprotkb/Q32KM8" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "Q32KM8", "url": "https://www.uniprot.org/uniprotkb/Q32KM8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "Q32KM8", "url": "https://www.uniprot.org/uniprotkb/Q32KM8" } ], "pmid": "" }, { "name": "regulation of cell population proliferation", "id": "GO:0042127", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042127", "evidence": [ { "database": "UniProtKB", "id": "Q32KM8", "url": "https://www.uniprot.org/uniprotkb/Q32KM8" } ], "pmid": "" }, { "name": "central nervous system development", "id": "GO:0007417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007417", "evidence": [ { "database": "UniProtKB", "id": "Q32KM8", "url": "https://www.uniprot.org/uniprotkb/Q32KM8" } ], "pmid": "" }, { "name": "response to wounding", "id": "GO:0009611", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009611", "evidence": [ { "database": "UniProtKB", "id": "Q32KM8", "url": "https://www.uniprot.org/uniprotkb/Q32KM8" } ], "pmid": "" }, { "name": "anaphase-promoting complex-dependent catabolic process", "id": "GO:0031145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031145", "evidence": [ { "database": "UniProtKB", "id": "Q32KM8", "url": "https://www.uniprot.org/uniprotkb/Q32KM8" } ], "pmid": "" }, { "name": "cellular senescence", "id": "GO:0090398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090398", "evidence": [ { "database": "UniProtKB", "id": "Q32KM8", "url": "https://www.uniprot.org/uniprotkb/Q32KM8" } ], "pmid": "" }, { "name": "G1 to G0 transition", "id": "GO:0070314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070314", "evidence": [ { "database": "UniProtKB", "id": "Q32KM8", "url": "https://www.uniprot.org/uniprotkb/Q32KM8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KM8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 147, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KM8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KM8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 3, "end_pos": 5 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KN2-1", "uniprot_ac": "Q32KN2", "uniprot_id": "BNIP3_BOVIN", "mass": { "chemical_mass": 21886.0, "monoisotopic_mass": 21886.0 }, "refseq": { "ac": "NP_001069834", "name": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069834" }, "gene_names": [ { "name": "BNIP3", "type": "recommended", "evidence": [ { "id": "Q32KN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN2" } ] }, { "name": "BNIP3", "type": "synonym", "evidence": [ { "id": "NP_001069834", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069834" } ] } ], "protein_names": [ { "name": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3", "type": "recommended", "evidence": [ { "id": "Q32KN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN2/entry#names_and_taxonomy" } ] }, { "name": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3", "type": "synonym", "evidence": [ { "id": "NP_001069834", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069834" } ] }, { "name": "BCL2/adenovirus E1B 19kDa interacting protein 3", "type": "synonym", "evidence": [ { "id": "NP_001069834", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069834" } ] } ], "function": [ { "annotation": "Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2 (By similarity). Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32KN2", "url": "https://www.uniprot.org/uniprotkb/Q32KN2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KN2", "url": "https://www.uniprot.org/uniprotkb/Q32KN2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BNIP3", "url": "https://www.uniprot.org/uniprotkb/Q32KN2", "locus": {} } ], "crossref": [ { "id": "Q32KN2", "url": "https://alphafold.ebi.ac.uk/entry/Q32KN2", "database": "AlphaFoldDB", "categories": [] }, { "id": "615342", "url": "https://www.ncbi.nlm.nih.gov/gene/615342", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010548", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010548", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615342", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615342", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32KN2", "url": "https://www.orthodb.org/?gene=Q32KN2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15186", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15186", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15186:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15186:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06553", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06553", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069834", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069834", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KN2", "url": "https://www.uniprot.org/uniprotkb/Q32KN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KN2-1", "url": "https://www.uniprot.org/uniprotkb/Q32KN2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSQSESPGLQEESLHGSWVELHFGSNGNGSSVPDSVSIYKGDMEKILLDAQHESGRSSSKSSHCDSPPRSQTPQDTNRASETDTHSLGEKNSSQSEEDYMERRKEVESILKKNSDWIWDWSSRPENVPPAKEFLLFKHPKRTPTLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSHLLAIGLGIYIGRRLTTSTSTF", "length": 196, "header": "sp|Q32KN2-1|BNIP3_BOVIN Isoform 1 of BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 OS=Bos taurus OX=9913 GN=BNIP3 PE=2 SV=1 CANONICAL=Q32KN2-1" }, "isoforms": [ { "isoform_ac": "Q32KN2-1", "url": "https://www.uniprot.org/uniprotkb/Q32KN2/entry#Q32KN2-1", "sequence": { "sequence": "MSQSESPGLQEESLHGSWVELHFGSNGNGSSVPDSVSIYKGDMEKILLDAQHESGRSSSKSSHCDSPPRSQTPQDTNRASETDTHSLGEKNSSQSEEDYMERRKEVESILKKNSDWIWDWSSRPENVPPAKEFLLFKHPKRTPTLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSHLLAIGLGIYIGRRLTTSTSTF", "length": 196, "header": "sp|Q32KN2-1|BNIP3_BOVIN Isoform 1 of BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 OS=Bos taurus OX=9913 GN=BNIP3 PE=2 SV=1 CANONICAL=Q32KN2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 54, "end_pos": 54, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32KN2", "url": "https://www.uniprot.org/uniprotkb/Q32KN2" } ], "site_lbl": "Ser54" }, { "start_pos": 66, "end_pos": 66, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32KN2", "url": "https://www.uniprot.org/uniprotkb/Q32KN2" } ], "site_lbl": "Ser66" }, { "start_pos": 86, "end_pos": 86, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32KN2", "url": "https://www.uniprot.org/uniprotkb/Q32KN2" } ], "site_lbl": "Ser86" }, { "start_pos": 92, "end_pos": 92, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32KN2", "url": "https://www.uniprot.org/uniprotkb/Q32KN2" } ], "site_lbl": "Ser92" }, { "start_pos": 95, "end_pos": 95, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32KN2", "url": "https://www.uniprot.org/uniprotkb/Q32KN2" } ], "site_lbl": "Ser95" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615342", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615342", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32KN2", "url": "https://www.uniprot.org/uniprotkb/Q32KN2" } ], "pmid": "" }, { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "Q32KN2", "url": "https://www.uniprot.org/uniprotkb/Q32KN2" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q32KN2", "url": "https://www.uniprot.org/uniprotkb/Q32KN2" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "Q32KN2", "url": "https://www.uniprot.org/uniprotkb/Q32KN2" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q32KN2", "url": "https://www.uniprot.org/uniprotkb/Q32KN2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q32KN2", "url": "https://www.uniprot.org/uniprotkb/Q32KN2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "Q32KN2", "url": "https://www.uniprot.org/uniprotkb/Q32KN2" } ], "pmid": "" }, { "name": "mitochondrial protein catabolic process", "id": "GO:0035694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035694", "evidence": [ { "database": "UniProtKB", "id": "Q32KN2", "url": "https://www.uniprot.org/uniprotkb/Q32KN2" } ], "pmid": "" }, { "name": "mitochondrial outer membrane permeabilization", "id": "GO:0097345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097345", "evidence": [ { "database": "UniProtKB", "id": "Q32KN2", "url": "https://www.uniprot.org/uniprotkb/Q32KN2" } ], "pmid": "" }, { "name": "positive regulation of programmed cell death", "id": "GO:0043068", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043068", "evidence": [ { "database": "UniProtKB", "id": "Q32KN2", "url": "https://www.uniprot.org/uniprotkb/Q32KN2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 149, "end_pos": 151, "annotation": "n_glycosylation_sequon" }, { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KN2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 196, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KN2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KN2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 54, 66, 86, 92, 95 ], "sequon_annotation_sites": [ { "start_pos": 149, "end_pos": 151 }, { "start_pos": 28, "end_pos": 30 }, { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KN9-1", "uniprot_ac": "Q32KN9", "uniprot_id": "PRLD1_BOVIN", "mass": { "chemical_mass": 25248.0, "monoisotopic_mass": 25248.0 }, "refseq": { "ac": "NP_001033227", "name": "PRELI domain-containing protein 1, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033227" }, "gene_names": [ { "name": "PRELID1", "type": "recommended", "evidence": [ { "id": "Q32KN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN9" } ] }, { "name": "PRELID1", "type": "synonym", "evidence": [ { "id": "NP_001033227", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033227" } ] }, { "name": "PX19", "type": "synonym", "evidence": [ { "id": "NP_001033227", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033227" } ] } ], "protein_names": [ { "name": "PRELI domain-containing protein 1, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q32KN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN9/entry#names_and_taxonomy" } ] }, { "name": "PRELI domain-containing protein 1, mitochondrial precursor", "type": "synonym", "evidence": [ { "id": "NP_001033227", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033227" } ] }, { "name": "PRELI domain-containing protein 1, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001033227", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033227" } ] }, { "name": "px19-like protein", "type": "synonym", "evidence": [ { "id": "NP_001033227", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033227" } ] } ], "function": [ { "annotation": "Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32KN9", "url": "https://www.uniprot.org/uniprotkb/Q32KN9#function" }, { "database": "UniProtKB", "id": "Q9Y255", "url": "https://www.uniprot.org/uniprotkb/Q9Y255#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KN9", "url": "https://www.uniprot.org/uniprotkb/Q32KN9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRELID1", "url": "https://www.uniprot.org/uniprotkb/Q32KN9", "locus": { "chromosome": "7", "start_pos": 38779622, "end_pos": 38775913, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005009", "url": "https://www.ensembl.org/id/ENSBTAG00000005009" } ] } } ], "crossref": [ { "id": "Q32KN9", "url": "https://alphafold.ebi.ac.uk/entry/Q32KN9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005009", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005009", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "523609", "url": "https://www.ncbi.nlm.nih.gov/gene/523609", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523609", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523609", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GYEFFKC", "url": "https://omabrowser.org/oma/group/GYEFFKC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32KN9", "url": "https://www.orthodb.org/?gene=Q32KN9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11158", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11158", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6803204", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6803204", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001033227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033227", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "36435", "url": "https://www.rhea-db.org/rhea/36435", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32KN9", "url": "https://www.uniprot.org/uniprotkb/Q32KN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KN9-1", "url": "https://www.uniprot.org/uniprotkb/Q32KN9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVKYFLGQSVLRSSWDQVFAAFWQRYPNPYSKHVLTEDIVHREVTSDQKLLSRRLLTKTNRMPRWAERLFPANVAHSVYILEDSIVDPQNQTMTTFTWNINHARLMVVEERCVYRVNSDNSGWTEIRREAWVSSSLFGVSRAVQEFGLARFKSNVTKTMKGFEYILAKLQGEAPPKTLVETAKEAKEKAKETALAATEKAKDLASKAATKKQQQQQQFV", "length": 219, "header": "sp|Q32KN9-1|PRLD1_BOVIN Isoform 1 of PRELI domain-containing protein 1, mitochondrial OS=Bos taurus OX=9913 GN=PRELID1 PE=2 SV=1 CANONICAL=Q32KN9-1" }, "isoforms": [ { "isoform_ac": "Q32KN9-1", "url": "https://www.uniprot.org/uniprotkb/Q32KN9/entry#Q32KN9-1", "sequence": { "sequence": "MVKYFLGQSVLRSSWDQVFAAFWQRYPNPYSKHVLTEDIVHREVTSDQKLLSRRLLTKTNRMPRWAERLFPANVAHSVYILEDSIVDPQNQTMTTFTWNINHARLMVVEERCVYRVNSDNSGWTEIRREAWVSSSLFGVSRAVQEFGLARFKSNVTKTMKGFEYILAKLQGEAPPKTLVETAKEAKEKAKETALAATEKAKDLASKAATKKQQQQQQFV", "length": 219, "header": "sp|Q32KN9-1|PRLD1_BOVIN Isoform 1 of PRELI domain-containing protein 1, mitochondrial OS=Bos taurus OX=9913 GN=PRELID1 PE=2 SV=1 CANONICAL=Q32KN9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:523609", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523609", "resource": "KEGG Pathway" }, { "id": "R-BTA-6803204", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6803204", "resource": "Reactome", "description": "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" } ], "orthologs": [ { "uniprot_canonical_ac": "F1NAR2-1", "protein_name": "PRELI domain containing 1", "gene_name": "PRELID1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGKYCASLGVLKGPWDQVFAAFWQRYPNPYSKHVLTEDIVHREVTADHKLLSRRLLTKTNRMPRWAERFFPANVAHSVYILEDSIVDPKNRTMTTFTWNINHARLMAVEERCIYRVNPENSNWTEVKREAWVSSSLFGVSRAVQEFGLARFKSNVTKSTKGFEYVLARMQGEAPSKTLVETAKEATEKAKETALAATEKAKDLATKAATKKKQFV", "length": 215 }, "evidence": [ { "id": "Q32KN9", "url": "https://omabrowser.org/oma/group/Q32KN9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q05776-1", "protein_name": "Protein UPS1, mitochondrial", "gene_name": "UPS1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MVLLHKSTHIFPTDFASVSRAFFNRYPNPYSPHVLSIDTISRNVDQEGNLRTTRLLKKSGKLPTWVKPFLRGITETWIIEVSVVNPANSTMKTYTRNLDHTGIMKVEEYTTYQFDSATSSTIADSRVKFSSGFNMGIKSKVEDWSRTKFDENVKKSRMGMAFVIQKLEEARNPQF", "length": 175 }, "evidence": [ { "id": "Q32KN9", "url": "https://omabrowser.org/oma/group/Q32KN9/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q8R107-1", "protein_name": "PRELI domain-containing protein 1, mitochondrial", "gene_name": "Prelid1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVKYFLGQSVLRSSWDQVFAAFWQRYPNPYSKHVLTEDIVHREVTPDQKLLSRRLLTKTNRMPRWAERLFPANVAHSVYILEDSIVDPQNQTMTTFTWNINHARLMVVEERCVYCVNSDNSGWTEIRREAWVSSSLFGVSRAVQEFGLARFKSNVTKTMKGFEYILAKLQGEAPSKTLVETAKEAKEKAKETALAATEKAKDLANKAATKQQQRQLV", "length": 217 }, "evidence": [ { "id": "Q32KN9", "url": "https://omabrowser.org/oma/group/Q32KN9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9V579-1", "protein_name": "Protein preli-like", "gene_name": "prel", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVVAASTCRTETVFDYSWMNVVVAYWNRYPNPSSTHVLTEDTIQREVRDGKLFSRRLLSKTNPVPKWGARFYNNVPVKIVEDSVLDPVKKTFTTFTRNLGMTKIMKVDEIVVYSEQKDGSTLAVRRAYISSQVFGFSRAIRAFGIERFKANGNKASNGFNYVLRRMFPDSLVGGGHHQHAVTTTSPAGELPATTITVSTTNGSLNNQGALKSAAKVGYEFFKSHASKIAQLFSVKN", "length": 236 }, "evidence": [ { "id": "Q32KN9", "url": "https://omabrowser.org/oma/group/Q32KN9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y255-1", "protein_name": "PRELI domain-containing protein 1, mitochondrial", "gene_name": "PRELID1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVKYFLGQSVLRSSWDQVFAAFWQRYPNPYSKHVLTEDIVHREVTPDQKLLSRRLLTKTNRMPRWAERLFPANVAHSVYVLEDSIVDPQNQTMTTFTWNINHARLMVVEERCVYCVNSDNSGWTEIRREAWVSSSLFGVSRAVQEFGLARFKSNVTKTMKGFEYILAKLQGEAPSKTLVETAKEAKEKAKETALAATEKAKDLASKAATKKQQQQQQFV", "length": 219 }, "evidence": [ { "id": "Q32KN9", "url": "https://omabrowser.org/oma/group/Q32KN9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphatidic acid transfer activity", "id": "GO:1990050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990050", "evidence": [ { "database": "UniProtKB", "id": "Q32KN9", "url": "https://www.uniprot.org/uniprotkb/Q32KN9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial intermembrane space", "id": "GO:0005758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005758", "evidence": [ { "database": "UniProtKB", "id": "Q32KN9", "url": "https://www.uniprot.org/uniprotkb/Q32KN9" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q32KN9", "url": "https://www.uniprot.org/uniprotkb/Q32KN9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "Q32KN9", "url": "https://www.uniprot.org/uniprotkb/Q32KN9" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q32KN9", "url": "https://www.uniprot.org/uniprotkb/Q32KN9" } ], "pmid": "" }, { "name": "regulation of mitochondrial membrane potential", "id": "GO:0051881", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051881", "evidence": [ { "database": "UniProtKB", "id": "Q32KN9", "url": "https://www.uniprot.org/uniprotkb/Q32KN9" } ], "pmid": "" }, { "name": "phospholipid transport", "id": "GO:0015914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015914", "evidence": [ { "database": "UniProtKB", "id": "Q32KN9", "url": "https://www.uniprot.org/uniprotkb/Q32KN9" } ], "pmid": "" }, { "name": "regulation of T cell differentiation", "id": "GO:0045580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045580", "evidence": [ { "database": "UniProtKB", "id": "Q32KN9", "url": "https://www.uniprot.org/uniprotkb/Q32KN9" } ], "pmid": "" }, { "name": "negative regulation of mitochondrial membrane potential", "id": "GO:0010917", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010917", "evidence": [ { "database": "UniProtKB", "id": "Q32KN9", "url": "https://www.uniprot.org/uniprotkb/Q32KN9" } ], "pmid": "" }, { "name": "positive regulation of endopeptidase activity", "id": "GO:0010950", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010950", "evidence": [ { "database": "UniProtKB", "id": "Q32KN9", "url": "https://www.uniprot.org/uniprotkb/Q32KN9" } ], "pmid": "" }, { "name": "negative regulation of release of cytochrome c from mitochondria", "id": "GO:0090201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090201", "evidence": [ { "database": "UniProtKB", "id": "Q32KN9", "url": "https://www.uniprot.org/uniprotkb/Q32KN9" } ], "pmid": "" }, { "name": "regulation of membrane lipid distribution", "id": "GO:0097035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097035", "evidence": [ { "database": "UniProtKB", "id": "Q32KN9", "url": "https://www.uniprot.org/uniprotkb/Q32KN9" } ], "pmid": "" }, { "name": "positive regulation of cellular respiration", "id": "GO:1901857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901857", "evidence": [ { "database": "UniProtKB", "id": "Q32KN9", "url": "https://www.uniprot.org/uniprotkb/Q32KN9" } ], "pmid": "" }, { "name": "positive regulation of T cell apoptotic process", "id": "GO:0070234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070234", "evidence": [ { "database": "UniProtKB", "id": "Q32KN9", "url": "https://www.uniprot.org/uniprotkb/Q32KN9" } ], "pmid": "" }, { "name": "positive regulation of phospholipid transport", "id": "GO:2001140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001140", "evidence": [ { "database": "UniProtKB", "id": "Q32KN9", "url": "https://www.uniprot.org/uniprotkb/Q32KN9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "36435", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn-glycero-3-phosphate(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MUP9-1" ], "evidence": [ { "id": "36435", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36435" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MUP9", "gene_name": "VAT1", "activity": [ { "ec_number": "1.6.5.5", "activity": "2 1,2-naphthoquinone + NADPH + H(+) = 2 1,2-naphthosemiquinone + NADP(+).", "evidence": [ { "id": "F1MUP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUP9" } ] }, { "ec_number": "1.6.5.5", "activity": "", "evidence": [ { "id": "F1MUP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUP9" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KN9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 219, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KN9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KN9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32KN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KN9" }, { "id": "PRU00158", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00158" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PRELI/MSF1", "eco_id": "ECO_0000255", "start_pos": 36, "end_pos": 174, "start_aa": "Thr", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 154, "end_pos": 156 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KP9-1", "uniprot_ac": "Q32KP9", "uniprot_id": "NTF2_BOVIN", "mass": { "chemical_mass": 14478.0, "monoisotopic_mass": 14478.0 }, "refseq": { "ac": "NP_001032713", "name": "nuclear transport factor 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032713" }, "gene_names": [ { "name": "NUTF2", "type": "recommended", "evidence": [ { "id": "Q32KP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KP9" } ] }, { "name": "NUTF2", "type": "synonym", "evidence": [ { "id": "NP_001032713", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032713" } ] } ], "protein_names": [ { "name": "Nuclear transport factor 2", "type": "recommended", "evidence": [ { "id": "Q32KP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KP9/entry#names_and_taxonomy" } ] }, { "name": "NTF-2", "type": "synonym", "evidence": [ { "id": "NP_001032713", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032713" }, { "id": "Q32KP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KP9/entry#names_and_taxonomy" } ] }, { "name": "nuclear transport factor 2", "type": "synonym", "evidence": [ { "id": "NP_001032713", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032713" } ] } ], "function": [ { "annotation": "Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.", "evidence": [ { "database": "UniProtKB", "id": "Q32KP9", "url": "https://www.uniprot.org/uniprotkb/Q32KP9#function" }, { "database": "UniProtKB", "id": "P61970", "url": "https://www.uniprot.org/uniprotkb/P61970#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KP9", "url": "https://www.uniprot.org/uniprotkb/Q32KP9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NUTF2", "url": "https://www.uniprot.org/uniprotkb/Q32KP9", "locus": { "chromosome": "18", "start_pos": 35368777, "end_pos": 35354061, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006414", "url": "https://www.ensembl.org/id/ENSBTAG00000006414" } ] } } ], "crossref": [ { "id": "Q32KP9", "url": "https://alphafold.ebi.ac.uk/entry/Q32KP9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006414", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006414", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00780", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00780", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614921", "url": "https://www.ncbi.nlm.nih.gov/gene/614921", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002075", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002075", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614921", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614921", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QFVEYYY", "url": "https://omabrowser.org/oma/group/QFVEYYY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32KP9", "url": "https://www.orthodb.org/?gene=Q32KP9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12612", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12612", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02136", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02136", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032713", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KP9", "url": "https://www.uniprot.org/uniprotkb/Q32KP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KP9-1", "url": "https://www.uniprot.org/uniprotkb/Q32KP9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDKPIWEQIGSSFIQHYYQLFDNDRTQLGAIYIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMFRLALHNFG", "length": 127, "header": "sp|Q32KP9-1|NTF2_BOVIN Isoform 1 of Nuclear transport factor 2 OS=Bos taurus OX=9913 GN=NUTF2 PE=2 SV=1 CANONICAL=Q32KP9-1" }, "isoforms": [ { "isoform_ac": "Q32KP9-1", "url": "https://www.uniprot.org/uniprotkb/Q32KP9/entry#Q32KP9-1", "sequence": { "sequence": "MGDKPIWEQIGSSFIQHYYQLFDNDRTQLGAIYIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMFRLALHNFG", "length": 127, "header": "sp|Q32KP9-1|NTF2_BOVIN Isoform 1 of Nuclear transport factor 2 OS=Bos taurus OX=9913 GN=NUTF2 PE=2 SV=1 CANONICAL=Q32KP9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614921", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614921", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1NLL4-1", "protein_name": "Nuclear transport factor 2", "gene_name": "NUTF2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGDKPIWEQIGSSFVQHYYQLFDADRTQLGAIYIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCILSMVVGQLKADEDPIMGFHQIFLLKNINDAWVCTNDMFRLALHNFG", "length": 127 }, "evidence": [ { "id": "Q32KP9", "url": "https://omabrowser.org/oma/group/Q32KP9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HKX2-1", "protein_name": "Nuclear transport factor 2", "gene_name": "Nutf2", 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"Rattus norvegicus", "sequence": { "sequence": "MGDKPIWEQIGSSFIQHYYQLFDNDRTQLGAIYIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMFRLALHNFG", "length": 127 }, "evidence": [ { "id": "Q32KP9", "url": "https://omabrowser.org/oma/group/Q32KP9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86HW7-1", "protein_name": "Nuclear transport factor 2", "gene_name": "nutf2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MQSVDPQVVGVGKQFVEHYYGIFDSNRAGLTQIYQQQTTLTWEGKFLSGADAIVKHIVELPFQQTNRKINSIDCQQTYQPGIMITVTGTLIIDGEAKNQLKFVQVFNLASNNGSFLLINDFFRLVLD", "length": 127 }, "evidence": [ { "id": "Q32KP9", "url": "https://omabrowser.org/oma/group/Q32KP9/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9C7F5-1", "protein_name": "Nuclear transport factor 2B", "gene_name": "NTF2B", "tax_id": 3702, "organism": 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"pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KP9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 127, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KP9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KP9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32KP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KP9" }, { "id": "PRU00137", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00137" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NTF2", "eco_id": "ECO_0000255", "start_pos": 10, "end_pos": 121, "start_aa": "Ile", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"id": "bta:616088", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616088", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LUT4-1", "protein_name": "Musculoskeletal embryonic nuclear protein 1", "gene_name": "Mustn1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSEVGTPEAPIKKKRPPVKEEDLKGARGNLAKNQEIKSKTYQVMRDCEQAGSAAPSVFSRNRTGTETVFEKPKEGPAKSVFG", "length": 82 }, "evidence": [ { "id": "Q32KU9", "url": "https://omabrowser.org/oma/group/Q32KU9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q76MS9-1", "protein_name": "Musculoskeletal embryonic nuclear protein 1", "gene_name": "MUSTN1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSQPDPVKKKRPPVKEEDLKGARGNLSKNQEIKSKTYQVMKQCEQMGSAAPSIFSRARTGSETVFEKSKDEPPKSVFG", "length": 78 }, "evidence": [ { "id": "Q32KU9", "url": "https://omabrowser.org/oma/group/Q32KU9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8IVN3-1", "protein_name": "Musculoskeletal embryonic nuclear protein 1", "gene_name": "MUSTN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSQAGAQEAPIKKKRPPVKDEDLKGARGNLTKNQEIKSKTYQVMRECEQAGSAAPSVFSRTRTGTETVFEKPKAGPTKSVFG", "length": 82 }, "evidence": [ { "id": "Q32KU9", "url": "https://omabrowser.org/oma/group/Q32KU9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99JI1-1", "protein_name": "Musculoskeletal embryonic nuclear protein 1", "gene_name": "Mustn1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSEAGTPEGPIKKKRPPVKEEDLKGARGTLAKNQDIKSKTYQVMRDYEQAGSAAPSVFSRNRTGTETVFEKPKEGPAKSVFG", "length": 82 }, "evidence": [ { "id": "Q32KU9", "url": "https://omabrowser.org/oma/group/Q32KU9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": 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Can also catalyze the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate, but with a reduced activity.", "evidence": [ { "database": "UniProtKB", "id": "Q32KV0", "url": "https://www.uniprot.org/uniprotkb/Q32KV0#function" }, { "database": "UniProtKB", "id": "P18669", "url": "https://www.uniprot.org/uniprotkb/P18669#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KV0", "url": "https://www.uniprot.org/uniprotkb/Q32KV0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PGAM2", "url": "https://www.uniprot.org/uniprotkb/Q32KV0", "locus": { "chromosome": "22", "start_pos": 390224, "end_pos": 392579, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014547", "url": 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Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32KV2", "url": "https://www.uniprot.org/uniprotkb/Q32KV2#function" }, { "database": "UniProtKB", "id": "Q8BVN9", "url": "https://www.uniprot.org/uniprotkb/Q8BVN9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KV2", "url": "https://www.uniprot.org/uniprotkb/Q32KV2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAEL", "url": "https://www.uniprot.org/uniprotkb/Q32KV2", "locus": { "chromosome": "3", "start_pos": 1829693, "end_pos": 1901661, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016550", "url": "https://www.ensembl.org/id/ENSBTAG00000016550" } ] } } ], "crossref": [ { 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"id": "bta:541073", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541073", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32KV2", "url": "https://www.orthodb.org/?gene=Q32KV2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21358", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21358", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21358:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21358:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09011", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09011", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033282", "url": 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"Q32KV2-1", "url": "https://www.uniprot.org/uniprotkb/Q32KV2/entry#Q32KV2-1", "sequence": { "sequence": "MPNRRASRNAYYFFVQEKIPELRRRGLPVARVADAIPYCSADWALLKEEEKEKYAEMAREWRAAQGKDSGPSEKQKPVCTPLRKPGMLVPKQNVSPPDLSGLSLKSDQALLGGIFYFLNIFSHGELPPHCEQRFLPCEIGCVKYSLQEGIMADFHSFINPGDSSHKIPISHFESGHDQATVIENLYRFIHPNPGNWPPIYCKSDDRARVNWCLKHMAKSSEIRQDLELLTVEDLVVGIYQQKFLKEPSKTWVRSLLEVAMWDYSSNTRCKWHEENDILFCALAVCKKIANCISNSLATLFGIQLTEAHVPLQDYEASNSVTPKMVVLDAGRYQKLRVESPGFSHFSSSNQEQRSNTPTGDYPSGVKISGQNSSVRGRGITRLLESISSSSSNIHKFSNCETPVSPYTSPKHGYKSFSSLS", "length": 420, "header": "sp|Q32KV2-1|MAEL_BOVIN Isoform 1 of Protein maelstrom homolog OS=Bos taurus OX=9913 GN=MAEL PE=2 SV=1 CANONICAL=Q32KV2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:541073", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541073", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32KV2", "url": "https://www.uniprot.org/uniprotkb/Q32KV2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32KV2", "url": "https://www.uniprot.org/uniprotkb/Q32KV2" } ], "pmid": "" }, { "name": "piP-body", "id": "GO:0071547", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071547", "evidence": [ { "database": "UniProtKB", "id": "Q32KV2", "url": "https://www.uniprot.org/uniprotkb/Q32KV2" } ], "pmid": "" }, { "name": "P granule", "id": "GO:0043186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043186", "evidence": [ { "database": "UniProtKB", "id": "Q32KV2", "url": "https://www.uniprot.org/uniprotkb/Q32KV2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q32KV2", "url": "https://www.uniprot.org/uniprotkb/Q32KV2" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q32KV2", "url": "https://www.uniprot.org/uniprotkb/Q32KV2" } ], "pmid": "" }, { "name": "regulation of miRNA-mediated gene silencing", "id": "GO:0060964", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060964", "evidence": [ { "database": "UniProtKB", "id": "Q32KV2", "url": "https://www.uniprot.org/uniprotkb/Q32KV2" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "Q32KV2", "url": "https://www.uniprot.org/uniprotkb/Q32KV2" } ], "pmid": "" }, { "name": "male meiotic nuclear division", "id": "GO:0007140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007140", "evidence": [ { "database": "UniProtKB", "id": "Q32KV2", "url": "https://www.uniprot.org/uniprotkb/Q32KV2" } ], "pmid": "" }, { "name": "regulatory ncRNA-mediated gene silencing", "id": "GO:0031047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031047", "evidence": [ { "database": "UniProtKB", "id": "Q32KV2", "url": "https://www.uniprot.org/uniprotkb/Q32KV2" } ], "pmid": "" }, { "name": "piRNA processing", "id": "GO:0034587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034587", "evidence": [ { "database": "UniProtKB", "id": "Q32KV2", "url": "https://www.uniprot.org/uniprotkb/Q32KV2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "Q32KV2", "url": "https://www.uniprot.org/uniprotkb/Q32KV2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KV2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 420, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KV2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KV2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 371, "end_pos": 373 }, { "start_pos": 93, "end_pos": 95 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KW0-1", "uniprot_ac": "Q32KW0", "uniprot_id": "NFYB_BOVIN", "mass": { "chemical_mass": 22787.0, "monoisotopic_mass": 22787.0 }, "refseq": { "ac": "NP_001073254", "name": "nuclear transcription factor Y subunit beta", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073254" }, "gene_names": [ { "name": "NFYB", "type": "recommended", "evidence": [ { "id": "Q32KW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW0" } ] }, { "name": "NFYB", "type": "synonym", "evidence": [ { "id": "NP_001073254", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073254" } ] } ], "protein_names": [ { "name": "Nuclear transcription factor Y subunit beta", "type": "recommended", "evidence": [ { "id": "Q32KW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW0/entry#names_and_taxonomy" } ] }, { "name": "CAAT box DNA-binding protein subunit B", "type": "synonym", "evidence": [ { "id": "Q32KW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW0/entry#names_and_taxonomy" } ] }, { "name": "NF-YB", "type": "synonym", "evidence": [ { "id": "Q32KW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW0/entry#names_and_taxonomy" } ] }, { "name": "Nuclear transcription factor Y subunit B", "type": "synonym", "evidence": [ { "id": "Q32KW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW0/entry#names_and_taxonomy" } ] }, { "name": "nuclear transcription factor Y subunit beta", "type": "synonym", "evidence": [ { "id": "NP_001073254", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073254" } ] }, { "name": "nuclear transcription factor Y, beta", "type": "synonym", "evidence": [ { "id": "NP_001073254", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073254" } ] } ], "function": [ { "annotation": "Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32KW0", "url": "https://www.uniprot.org/uniprotkb/Q32KW0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KW0", "url": "https://www.uniprot.org/uniprotkb/Q32KW0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NFYB", "url": "https://www.uniprot.org/uniprotkb/Q32KW0", "locus": { "chromosome": "5", "start_pos": 67769135, "end_pos": 67788166, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030744", "url": "https://www.ensembl.org/id/ENSBTAG00000030744" } ] } } ], "crossref": [ { "id": "Q32KW0", "url": "https://alphafold.ebi.ac.uk/entry/Q32KW0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030744", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030744", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22907", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22907", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614382", "url": "https://www.ncbi.nlm.nih.gov/gene/614382", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003956", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003956", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003958", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003958", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027113", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027113", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614382", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614382", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NATHGDS", "url": "https://omabrowser.org/oma/group/NATHGDS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32KW0", "url": "https://www.orthodb.org/?gene=Q32KW0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11064", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11064", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11064:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11064:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00808", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00808", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073254", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073254", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KW0", "url": "https://www.uniprot.org/uniprotkb/Q32KW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KW0-1", "url": "https://www.uniprot.org/uniprotkb/Q32KW0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLPIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILFAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVTATDGLSEELTDEAFTNQLPAGLITADGQQQNVMVYTTSYQQISGVQQIQFS", "length": 207, "header": "sp|Q32KW0-1|NFYB_BOVIN Isoform 1 of Nuclear transcription factor Y subunit beta OS=Bos taurus OX=9913 GN=NFYB PE=2 SV=1 CANONICAL=Q32KW0-1" }, "isoforms": [ { "isoform_ac": "Q32KW0-1", "url": "https://www.uniprot.org/uniprotkb/Q32KW0/entry#Q32KW0-1", "sequence": { "sequence": "MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLPIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILFAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVTATDGLSEELTDEAFTNQLPAGLITADGQQQNVMVYTTSYQQISGVQQIQFS", "length": 207, "header": "sp|Q32KW0-1|NFYB_BOVIN Isoform 1 of Nuclear transcription factor Y subunit beta OS=Bos taurus OX=9913 GN=NFYB PE=2 SV=1 CANONICAL=Q32KW0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614382", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614382", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1T8K5-1", "protein_name": "Nuclear transcription factor Y subunit beta", "gene_name": "NFYB", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLPIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILFAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLITADGQQQNVMVYTTSYQQISGVQQIQFS", "length": 207 }, "evidence": [ { "id": "Q32KW0", "url": "https://omabrowser.org/oma/group/Q32KW0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MJM2-1", "protein_name": "Nuclear transcription factor Y subunit beta", "gene_name": "Nfyb", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLPIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILFAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVSATDGLSEELTEEAFTNQLPAGLITADGQQQNVMVYTTSYQQISGVQQIQFS", "length": 207 }, "evidence": [ { "id": "Q32KW0", "url": "https://omabrowser.org/oma/group/Q32KW0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { 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"evidence": [ { "id": "Q32KW0", "url": "https://omabrowser.org/oma/group/Q32KW0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P63140-1", "protein_name": "Nuclear transcription factor Y subunit beta", "gene_name": "Nfyb", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLPIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILFAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVSATDGLSEELTEEAFTNQLPAGLITADGQQQNVMVYTTSYQQISGVQQIQFS", "length": 207 }, "evidence": [ { "id": "Q32KW0", "url": "https://omabrowser.org/oma/group/Q32KW0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q32KW0", "url": 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"url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] } ] }, { "uniprot_ac": "Q5E9J3", "gene_name": "RASL11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q5E9J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J3" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q7YS69", "gene_name": "RHEBL1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q7YS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS69" } ] } ] }, { "uniprot_ac": "Q8HZJ5", "gene_name": "RAB27B", "activity": [ { "ec_number": 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"https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KW9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KW9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32KW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KW9" }, { "id": "PRU01053", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01053" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IRG-type G", "eco_id": "ECO_0000255", "start_pos": 53, "end_pos": 235, "start_aa": "Thr", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 247, 304 ], "sequon_annotation_sites": [ { "start_pos": 217, "end_pos": 219 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 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"table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KY6-1", "uniprot_ac": "Q32KY6", "uniprot_id": "DCTP1_BOVIN", "mass": { "chemical_mass": 18626.0, "monoisotopic_mass": 18626.0 }, "refseq": { "ac": "NP_001033291", "name": "dCTP pyrophosphatase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033291" }, "gene_names": [ { "name": "DCTPP1", "type": "recommended", "evidence": [ { "id": "Q32KY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ] }, { "name": "DCTPP1", "type": "synonym", "evidence": [ { "id": "NP_001033291", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033291" } ] }, { "name": "RS21-C6", "type": "synonym", "evidence": [ { "id": "NP_001033291", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033291" } ] }, { "name": "XTP3TPA", "type": "synonym", "evidence": [ { "id": "NP_001033291", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033291" } ] } ], "protein_names": [ { "name": "dCTP pyrophosphatase 1", "type": "recommended", "evidence": [ { "id": "Q32KY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY6/entry#names_and_taxonomy" } ] }, { "name": "3.6.1.12", "type": "synonym", "evidence": [ { "id": "Q32KY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY6/entry#names_and_taxonomy" } ] }, { "name": "Deoxycytidine-triphosphatase 1", "type": "synonym", "evidence": [ { "id": "Q32KY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY6/entry#names_and_taxonomy" } ] }, { "name": "XTP3-transactivated gene A protein homolog", "type": "synonym", "evidence": [ { "id": "NP_001033291", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033291" } ] }, { "name": "XTP3-transactivated protein A", "type": "synonym", "evidence": [ { "id": "NP_001033291", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033291" } ] }, { "name": "dCTP pyrophosphatase 1", "type": "synonym", "evidence": [ { "id": "NP_001033291", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033291" } ] }, { "name": "dCTPase 1", "type": "synonym", "evidence": [ { "id": "NP_001033291", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033291" }, { "id": "Q32KY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY6/entry#names_and_taxonomy" } ] }, { "name": "deoxycytidine-triphosphatase 1", "type": "synonym", "evidence": [ { "id": "NP_001033291", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033291" } ] } ], "function": [ { "annotation": "Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.", "evidence": [ { "database": "UniProtKB", "id": "Q32KY6", "url": "https://www.uniprot.org/uniprotkb/Q32KY6#function" }, { "database": "UniProtKB", "id": "Q9H773", "url": "https://www.uniprot.org/uniprotkb/Q9H773#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KY6", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DCTPP1", "url": "https://www.uniprot.org/uniprotkb/Q32KY6", "locus": { "chromosome": "25", "start_pos": 26593347, "end_pos": 26599277, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039962", "url": "https://www.ensembl.org/id/ENSBTAG00000039962" } ] } } ], "crossref": [ { "id": "Q32KY6", "url": "https://alphafold.ebi.ac.uk/entry/Q32KY6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd11537", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11537", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614103", "url": "https://www.ncbi.nlm.nih.gov/gene/614103", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR025984", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025984", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052555", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052555", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614103", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614103", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32KY6", "url": "https://www.orthodb.org/?gene=Q32KY6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46523", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46523", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46523:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46523:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12643", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12643", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033291", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033291", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "22636", "url": "https://www.rhea-db.org/rhea/22636", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32KY6", "url": "https://www.uniprot.org/uniprotkb/Q32KY6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KY6-1", "url": "https://www.uniprot.org/uniprotkb/Q32KY6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSASEEMLGGARGESTTATGPFSFSSEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKPDEEPGPQAWSPRERAALQEELSDILIYLVALAARCRVDLPQAVLCKMDTNRRRYPVHLSRGSACKYTDLPHGATSENQAMGPADPASESTGQVST", "length": 169, "header": "sp|Q32KY6-1|DCTP1_BOVIN Isoform 1 of dCTP pyrophosphatase 1 OS=Bos taurus OX=9913 GN=DCTPP1 PE=2 SV=1 CANONICAL=Q32KY6-1" }, "isoforms": [ { "isoform_ac": "Q32KY6-1", "url": "https://www.uniprot.org/uniprotkb/Q32KY6/entry#Q32KY6-1", "sequence": { "sequence": "MSASEEMLGGARGESTTATGPFSFSSEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKPDEEPGPQAWSPRERAALQEELSDILIYLVALAARCRVDLPQAVLCKMDTNRRRYPVHLSRGSACKYTDLPHGATSENQAMGPADPASESTGQVST", "length": 169, "header": "sp|Q32KY6-1|DCTP1_BOVIN Isoform 1 of dCTP pyrophosphatase 1 OS=Bos taurus OX=9913 GN=DCTPP1 PE=2 SV=1 CANONICAL=Q32KY6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 84, "end_pos": 84, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32KY6", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ], "site_lbl": "Ser84" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:614103", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614103", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "dCTP catabolic process", "id": "GO:0006253", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006253", "evidence": [ { "database": "UniProtKB", "id": "Q32KY6", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ], "pmid": "" }, { "name": "DNA protection", "id": "GO:0042262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042262", "evidence": [ { "database": "UniProtKB", "id": "Q32KY6", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ], "pmid": "" }, { "name": "nucleoside triphosphate catabolic process", "id": "GO:0009143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009143", "evidence": [ { "database": "UniProtKB", "id": "Q32KY6", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "dCTP diphosphatase activity", "id": "GO:0047840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047840", "evidence": [ { "database": "UniProtKB", "id": "Q32KY6", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ], "pmid": "" }, { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "Q32KY6", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q32KY6", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ], "pmid": "" }, { "name": "nucleotide binding", "id": "GO:0000166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000166", "evidence": [ { "database": "UniProtKB", "id": "Q32KY6", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ], "pmid": "" }, { "name": "nucleoside triphosphate diphosphatase activity", "id": "GO:0047429", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047429", "evidence": [ { "database": "UniProtKB", "id": "Q32KY6", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32KY6", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q32KY6", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q32KY6", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "22636", "name": "", "equation": "dCTP + H2O = dCMP + diphosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SRN8-1", "Q32KY6-1" ], "evidence": [ { "id": "22636", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22636" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SRN8", "gene_name": "DCTPP1", "activity": [ { "ec_number": "3.6.1.12", "activity": "dCTP + H2O = dCMP + diphosphate + H(+).", "evidence": [ { "id": "A0AAA9SRN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8" } ] }, { "ec_number": "3.6.1.12", "activity": "", "evidence": [ { "id": "A0AAA9SRN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRN8" } ] } ] }, { "uniprot_ac": "Q32KY6", "gene_name": "DCTPP1", "activity": [ { "ec_number": "3.6.1.12", "activity": "dCTP + H2O = dCMP + diphosphate + H(+).", "evidence": [ { "id": "Q32KY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ] }, { "ec_number": "3.6.1.12", "activity": "", "evidence": [ { "id": "Q32KY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KY6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 169, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KY6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KY6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q32KY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY6#function" }, { "id": "Q32KY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ], "binding_site_uniprot": 62, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 62, "end_pos": 62, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32KY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY6#function" }, { "id": "Q32KY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ], "binding_site_uniprot": 65, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 65, "end_pos": 65, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32KY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY6#function" }, { "id": "Q32KY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ], "binding_site_uniprot": 94, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 94, "end_pos": 94, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q32KY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY6#function" }, { "id": "Q32KY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY6" } ], "binding_site_uniprot": 97, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 97, "end_pos": 97, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.1.12", "ec_name": "dCTP + H2O = dCMP + diphosphate + H(+).", "evidence": [ { "id": "3.6.1.12", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.12" }, { "id": "3.6.1.12", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.1.12" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 84 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32KZ2-1", "uniprot_ac": "Q32KZ2", "uniprot_id": "ACL7A_BOVIN", "mass": { "chemical_mass": 49016.0, "monoisotopic_mass": 49016.0 }, "refseq": { "ac": "NP_001033659", "name": "actin-like protein 7A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033659" }, "gene_names": [ { "name": "ACTL7A", "type": "recommended", "evidence": [ { "id": "Q32KZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2" } ] }, { "name": "ACTL7A", "type": "synonym", "evidence": [ { "id": "NP_001033659", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033659" } ] } ], "protein_names": [ { "name": "Actin-like protein 7A", "type": "recommended", "evidence": [ { "id": "Q32KZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2/entry#names_and_taxonomy" } ] }, { "name": "actin-like protein 7A", "type": "synonym", "evidence": [ { "id": "NP_001033659", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033659" } ] } ], "function": [ { "annotation": "Essential for normal spermatogenesis and male fertility. Required for normal sperm head morphology, acroplaxome formation, acrosome attachment, and acrosome granule stability. May anchor and stabilize acrosomal adherence to the acroplaxome at least in part by facilitating the presence of F-actin in the subacrosomal space. May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.", "evidence": [ { "database": "UniProtKB", "id": "Q32KZ2", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2#function" }, { "database": "UniProtKB", "id": "Q9QY84", "url": "https://www.uniprot.org/uniprotkb/Q9QY84#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32KZ2", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACTL7A", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2", "locus": { "chromosome": "8", "start_pos": 98467807, "end_pos": 98466288, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019468", "url": "https://www.ensembl.org/id/ENSBTAG00000019468" } ] } } ], "crossref": [ { "id": "Q32KZ2", "url": "https://alphafold.ebi.ac.uk/entry/Q32KZ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019468", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019468", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10214", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10214", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540296", "url": "https://www.ncbi.nlm.nih.gov/gene/540296", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031769", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031769", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540296", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540296", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DMWEYLF", "url": "https://omabrowser.org/oma/group/DMWEYLF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32KZ2", "url": "https://www.orthodb.org/?gene=Q32KZ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11937", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11937", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00022", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00022", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16840", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16840", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033659", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32KZ2", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32KZ2-1", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALESVWAPQAAVIGDGLSERVGEQASPQTQVLQTASLKDGPAKRAVWVRRDHSEPEPTTSPEVKKPKLELTKAVVVDLGTGYCKCGFAGLPKPTHRISTTVGKPYMETAKTGDNRKETFVGHELINPEVRLKLINPLRHGIIVDWDTVQDIWEYLFHQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFETFKTPAMHIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTTYLMCLMNTAGKHFTEGQLGIVEDIKKKCCFVALDPIEEKKVPATEHMIQYTLPDGQAIYLCQERFLCSEMFFKPSLIKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLSGFPNRLQKELSSMCPNDTPQVSVLPERDTAVWTGGSILASLQGFQPLWVHRSEYEEHGPFFLYRRCF", "length": 438, "header": "sp|Q32KZ2-1|ACL7A_BOVIN Isoform 1 of Actin-like protein 7A OS=Bos taurus OX=9913 GN=ACTL7A PE=2 SV=1 CANONICAL=Q32KZ2-1" }, "isoforms": [ { "isoform_ac": "Q32KZ2-1", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2/entry#Q32KZ2-1", "sequence": { "sequence": "MALESVWAPQAAVIGDGLSERVGEQASPQTQVLQTASLKDGPAKRAVWVRRDHSEPEPTTSPEVKKPKLELTKAVVVDLGTGYCKCGFAGLPKPTHRISTTVGKPYMETAKTGDNRKETFVGHELINPEVRLKLINPLRHGIIVDWDTVQDIWEYLFHQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFETFKTPAMHIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTTYLMCLMNTAGKHFTEGQLGIVEDIKKKCCFVALDPIEEKKVPATEHMIQYTLPDGQAIYLCQERFLCSEMFFKPSLIKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLSGFPNRLQKELSSMCPNDTPQVSVLPERDTAVWTGGSILASLQGFQPLWVHRSEYEEHGPFFLYRRCF", "length": 438, "header": "sp|Q32KZ2-1|ACL7A_BOVIN Isoform 1 of Actin-like protein 7A OS=Bos taurus OX=9913 GN=ACTL7A PE=2 SV=1 CANONICAL=Q32KZ2-1" }, "locus": { "chromosome": "8", "start_pos": 98467681, "end_pos": 98466368, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025933.4", "url": "https://www.ensembl.org/id/ENSBTAT00000025933.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025933.3", "url": "https://www.ensembl.org/id/ENSBTAP00000025933.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540296", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540296", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D0ZMQ0-1", "protein_name": "Actin-like protein 7A", "gene_name": "ACTL7A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALESMWAPQAAIIGDGPSKGGGEQASLQTQGLQTASLREGPAKRAVWVRRNHSETEEPTKSPAVKKPKLEVTKAVVVDLGTGYCKCGFAGLPKPTHRISSTVGKPYMETAKTGDNRKETFVGHELINPEVRLKLMNPLRHGIIVDWDTVQDIWEYLFHQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFETFKTPAMHIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTTYLMSLMNSSGKHFTEDQLCTVEDIKKKCCFVALDPIEEKKVPANEHTIQYTLPDGQQIYLCQERFLCSEMFFKPSLIKSMQLGLHTQTVSCLNKCDVALKRDLMGNILLCGGSTMLSGFPNRLQKELSSMCPNDTPQVNVLPERDTAVWTGGSILASLQGFQPLWVHRFEYEEHGPFFLYRRCF", "length": 439 }, "evidence": [ { "id": "Q32KZ2", "url": "https://omabrowser.org/oma/group/Q32KZ2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H9F4-1", "protein_name": "Actin-like protein 7A", "gene_name": "Actl7a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSLDSVWAPQTADIGDGPAKRAGDQASMQTQVLQTASLKDGPARRAVWVRRDSPETEDPAKSTVSKDRPKLEVTKAVVVDLGTGFCKCGFAGLPKPTHKISTTVGKPYMETAKTGDNRKETFVGHELLNPEIHLKLINPLRHGIIVDWDTVQDIWEYLFRQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFETFNTPAMHIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTAYLMNLMNNSGKYFTEDQIGTVEDIKTKCCFVALDPIEEKKIPPSEHEIHYTLPDGKEIRLGQERFLCSEMFFKPSLIKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLRGFPNRLQKELSSMCPNDTPQVNVLPERDTAVWTGGSILASLHGFQPLWVHRFEYEEHGPFFLYRRCF", "length": 440 }, "evidence": [ { "id": "Q32KZ2", "url": "https://omabrowser.org/oma/group/Q32KZ2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q641W9-1", "protein_name": "Actin-like protein 7A", "gene_name": "Actl7a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLDAVWAPQTANIGDGPAKKASDQTSMQTQVLQTASLRDGPAKRAVWVRRDNAEKEEPVKSAVSKDRPRLEVTKAVVVDLGTGFCKCGFAGLPKPTHKISTTVGKPYMETAKTGDNRKETFVGRELFNPDIHLKLVNPLRHGIIVDWDTVQDIWEYLFRQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFETFNTPAMHIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTNYLMNLMNNCGKHFSEDHLSIVEDIKTKCCFVALDPIEEKKIPPSEHEIHYTLPDGKEIRLGQERFLCSEMFFKPSLIKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLRGFPNRLQKELSSMCPNDTPQVNVLPERDTAVWTGGSILASLQGFQPLWVHRLEYEEHGPFFLYRRCF", "length": 440 }, "evidence": [ { "id": "Q32KZ2", "url": "https://omabrowser.org/oma/group/Q32KZ2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9QY84-1", "protein_name": "Actin-like protein 7A", "gene_name": "Actl7a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLDGVWAPQTANIGDGPAKKASDQASMQTQVLQTASLKDGPAKRAVWVRRDNAETEDPVKSTMSKDRPRLEVTKAVVVDLGTGFCKCGFAGLPKPTHKISTTVGKPYMETAKTGDNRKETFVGHELFNPDIHLKLVNPLRHGIIVDWDTVQDIWEYLFRQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFETFNTPAMHIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTTYLMNLMNNSGKHFSEDHLGIVEDIKTRCCFVALDPIEEKKIPAPEHEIHYTLPDGKEIRLGQERFLCSEMFFKPSLIKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLRGFPNRLQKELSSMCPNDTPQVNVLPERDTAVWTGGSILASLQGFQPLWVHRLEYEEHGPFFLYRRCF", "length": 440 }, "evidence": [ { "id": "Q32KZ2", "url": "https://omabrowser.org/oma/group/Q32KZ2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y615-1", "protein_name": "Actin-like protein 7A", "gene_name": "ACTL7A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWAPPAAIMGDGPTKKVGNQAPLQTQALQTASLRDGPAKRAVWVRHTSSEPQEPTESKAAKERPKQEVTKAVVVDLGTGYCKCGFAGLPRPTHKISTTVGKPYMETAKTGDNRKETFVGQELNNTNVHLKLVNPLRHGIIVDWDTVQDIWEYLFRQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFEAFNTPAMHIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTAYLLGLLNSAGNEFTQDQMGIVEDIKKKCCFVALDPIEEKKVPLSEHTIRYVLPDGKEIQLCQERFLCSEMFFKPSLIKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLSGFPNRLQKELSSMCPNDTPQVNVLPERDSAVWTGGSILASLQGFQPLWVHRFEYEEHGPFFLYRRCF", "length": 435 }, "evidence": [ { "id": "Q32KZ2", "url": "https://omabrowser.org/oma/group/Q32KZ2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32KZ2", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32KZ2", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q32KZ2", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2" } ], "pmid": "" }, { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "Q32KZ2", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2" } ], "pmid": "" }, { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "Q32KZ2", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2" } ], "pmid": "" }, { "name": "male germ cell nucleus", "id": "GO:0001673", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001673", "evidence": [ { "database": "UniProtKB", "id": "Q32KZ2", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q32KZ2", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2" } ], "pmid": "" }, { "name": "perinuclear theca", "id": "GO:0033011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033011", "evidence": [ { "database": "UniProtKB", "id": "Q32KZ2", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "fertilization", "id": "GO:0009566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009566", "evidence": [ { "database": "UniProtKB", "id": "Q32KZ2", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2" } ], "pmid": "" }, { "name": "spermatid development", "id": "GO:0007286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "evidence": [ { "database": "UniProtKB", "id": "Q32KZ2", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2" } ], "pmid": "" }, { "name": "single fertilization", "id": "GO:0007338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007338", "evidence": [ { "database": "UniProtKB", "id": "Q32KZ2", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2" } ], "pmid": "" }, { "name": "acrosome assembly", "id": "GO:0001675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001675", "evidence": [ { "database": "UniProtKB", "id": "Q32KZ2", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "Q32KZ2", "url": "https://www.uniprot.org/uniprotkb/Q32KZ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 387, "end_pos": 389, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32KZ2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 438, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32KZ2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32KZ2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 387, "end_pos": 389 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L17-1", "uniprot_ac": "Q32L17", "uniprot_id": "SPZ1_BOVIN", "mass": { "chemical_mass": 42777.0, "monoisotopic_mass": 42777.0 }, "refseq": { "ac": "NP_001035630", "name": "spermatogenic leucine zipper protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035630" }, "gene_names": [ { "name": "SPZ1", "type": "recommended", "evidence": [ { "id": "Q32L17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L17" } ] }, { "name": "SPZ1", "type": "synonym", "evidence": [ { "id": "NP_001035630", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035630" } ] } ], "protein_names": [ { "name": "Spermatogenic leucine zipper protein 1", "type": "recommended", "evidence": [ { "id": "Q32L17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L17/entry#names_and_taxonomy" } ] }, { "name": "spermatogenic leucine zipper protein 1", "type": "synonym", "evidence": [ { "id": "NP_001035630", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035630" } ] } ], "function": [ { "annotation": "Transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32L17", "url": "https://www.uniprot.org/uniprotkb/Q32L17#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L17", "url": "https://www.uniprot.org/uniprotkb/Q32L17" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPZ1", "url": "https://www.uniprot.org/uniprotkb/Q32L17", "locus": { "chromosome": "20", "start_pos": 277795, "end_pos": 276084, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024593", "url": "https://www.ensembl.org/id/ENSBTAG00000024593" } ] } } ], "crossref": [ { "id": "Q32L17", "url": "https://alphafold.ebi.ac.uk/entry/Q32L17", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024593", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024593", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "519496", "url": "https://www.ncbi.nlm.nih.gov/gene/519496", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR042961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519496", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519496", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ECQILEQ", "url": "https://omabrowser.org/oma/group/ECQILEQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32L17", "url": "https://www.orthodb.org/?gene=Q32L17", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47889", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47889", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47889:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47889:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001035630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035630", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32L17", "url": "https://www.uniprot.org/uniprotkb/Q32L17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L17-1", "url": "https://www.uniprot.org/uniprotkb/Q32L17-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVPTLSKTRKPPDLNEESLDLGIMIALFEIGSIPPVSCSSLPSLKSSDHEATEQRIAKKFESLLKEIKDIVKHVTSYEQKVTETKEPFKETNMFEVSELREKIIELDEINKELVKKLLASLDLGKKENAKKQEMRLDNQNSEDTVQDCSGDLVNCSKGQKALPETQLSKEKAKHGFPHIQEENIRLRNNMERLLQEAEHWSVEHTELSKLIKSYQKSQNDIKTLKNNGTHSPTQTNNESAKQELEEQVKRLKEDTYSLHLIATLLENECQILEQRVELLDELHHQKEEPLQGEPMQINHEQSDKEQKLPEAEKVKIHEKNMPEVEGTFHKRDQFFTSLDICHNKKAHNNQFNTRIAKRALVVKRPASSLS", "length": 371, "header": "sp|Q32L17-1|SPZ1_BOVIN Isoform 1 of Spermatogenic leucine zipper protein 1 OS=Bos taurus OX=9913 GN=SPZ1 PE=2 SV=1 CANONICAL=Q32L17-1" }, "isoforms": [ { "isoform_ac": "Q32L17-1", "url": "https://www.uniprot.org/uniprotkb/Q32L17/entry#Q32L17-1", "sequence": { "sequence": "MEVPTLSKTRKPPDLNEESLDLGIMIALFEIGSIPPVSCSSLPSLKSSDHEATEQRIAKKFESLLKEIKDIVKHVTSYEQKVTETKEPFKETNMFEVSELREKIIELDEINKELVKKLLASLDLGKKENAKKQEMRLDNQNSEDTVQDCSGDLVNCSKGQKALPETQLSKEKAKHGFPHIQEENIRLRNNMERLLQEAEHWSVEHTELSKLIKSYQKSQNDIKTLKNNGTHSPTQTNNESAKQELEEQVKRLKEDTYSLHLIATLLENECQILEQRVELLDELHHQKEEPLQGEPMQINHEQSDKEQKLPEAEKVKIHEKNMPEVEGTFHKRDQFFTSLDICHNKKAHNNQFNTRIAKRALVVKRPASSLS", "length": 371, "header": "sp|Q32L17-1|SPZ1_BOVIN Isoform 1 of Spermatogenic leucine zipper protein 1 OS=Bos taurus OX=9913 GN=SPZ1 PE=2 SV=1 CANONICAL=Q32L17-1" }, "locus": { "chromosome": "20", "start_pos": 277457, "end_pos": 276345, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034259.3", "url": "https://www.ensembl.org/id/ENSBTAT00000034259.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034157.2", "url": "https://www.ensembl.org/id/ENSBTAP00000034157.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 202, "end_pos": 202, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32L17", "url": "https://www.uniprot.org/uniprotkb/Q32L17" } ], "site_lbl": "Ser202" }, { "start_pos": 98, "end_pos": 98, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32L17", "url": "https://www.uniprot.org/uniprotkb/Q32L17" } ], "site_lbl": "Ser98" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:519496", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519496", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6AXY9-1", "protein_name": "Spermatogenic leucine zipper protein 1", "gene_name": "Spz1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADSDSSSEMPAHSPSPSPIPCAKQKPPNTGITISLLEIGSLPTFCCSSFSEPNNNMCPIRKQGKVQKFSNLLKDVKDVLKNIAGFEEKTTDGDPFDDTYIPEDLSELNIRGFDKRNKLRFKDDLFIHFDPERENTMRQEMLFKSHSAKNMVQKFARDLCNSEEKRGCDGVQLNAKRRRTGSVHIRGEYRKLRNNMEQLLQEADHWSKQHNELSELMRSYQECHKEIKDIVDCSRVCSQTQNNNEVPSKQKLEEQVKKLSQDTHSLHLIAALLENECQILQQRVDILRELHLHEAGPGHEKPLQTSGEQDKKCGEQDKKCGEQDKKCGEQDKKCPKLAEAEKMDGSKHTMKTTEGTITRKPKIFRCPNDCLTKKARNNRFNARVAKKSLVGKRRTISSFR", "length": 400 }, "evidence": [ { "id": "Q32L17", "url": "https://omabrowser.org/oma/group/Q32L17/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99MY0-1", "protein_name": "Spermatogenic leucine zipper protein 1", "gene_name": "Spz1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDTDNSAEMPARCPSPNPAPGAKQEPPNSGITISLLEIGSLPTVCYHSFPPPKNSICPVEKRGRVQKFSNLLKDVKDVLKNIAGVEEKSTVGEPFDDAYIPEDLSELNVRGVEKKNKIRFKDDLFIHFDPEREQNTMKQMLLKNQSAKNMVPKFARDLCNAEETRGFDGMLLSVKRPRNGSLHLRGEYRKLRNNMEQLLQEADHWSKQHNELSELMRSYQECQNETQETTDKDRACLQNQPNNGLSTKQKLEEQVKKLSHDTHALHLIAALLENECQVLQQRVDILKDFHLHEAGLGHEKPLQMSCEQDKKCPKLAEADKTDAFKHTTRATEGTIRKPKILRSPDVCFTKKARNNRFNARVAKKSLVGKRRTVSSFR", "length": 378 }, "evidence": [ { "id": "Q32L17", "url": "https://omabrowser.org/oma/group/Q32L17/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BXG8-1", "protein_name": "Spermatogenic leucine zipper protein 1", "gene_name": "SPZ1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASSAKSAEMPTISKTVNPTPDPHQEYLDPRITIALFEIGSHSPSSWGSLPFLKNSSHQVTEQQTAQKFNNLLKEIKDILKNMAGFEEKITEAKELFEETNITEDVSAHKENIRGLDKINEMLSTNLPVSLAPEKEDNEKKQEMILETNITEDVSAHKENIRGLDKINEMLSTNLPVSLAPEKEDNEKKQQMIMENQNSENTAQVFARDLVNRLEEKKVLNETQQSQEKAKNRLNVQEETMKIRNNMEQLLQEAEHWSKQHTELSKLIKSYQKSQKDISETLGNNGVGFQTQPNNEVSAKHELEEQVKKLSHDTYSLQLMAALLENECQILQQRVEILKELHHQKQGTLQEKPIQINYKQDKKNQKPSEAKKVEMYKQNKQAMKGTFWKKDRSCRSLDVCLNKKACNTQFNIHVARKALRGKMRSASSLR", "length": 430 }, "evidence": [ { "id": "Q32L17", "url": "https://omabrowser.org/oma/group/Q32L17/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q32L17", "url": "https://www.uniprot.org/uniprotkb/Q32L17" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": 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"pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" }, { "start_pos": 238, "end_pos": 240, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L17-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 371, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L17-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L17" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], 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Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and short non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs, respectively. 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"header": "tr|A0ABI0P6J7-1|A0ABI0P6J7_BOVIN Computationally mapped isoform of DNA-directed RNA polymerases I and III subunit RPAC1 OS=Bos taurus OX=9913 GN=POLR1C PE=3 SV=1 CANONICAL=Q32L22-1" }, "locus": { "chromosome": "23", "start_pos": 17068937, "end_pos": 17062591, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151805.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151805.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107002.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107002.1" } ] } }, { "isoform_ac": "Q32L22-1", "url": "https://www.uniprot.org/uniprotkb/Q32L22/entry#Q32L22-1", "sequence": { "sequence": "MAAAQAVEEMRTRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENSLEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPRLFEYRNQGDEGGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHRVYTRHMTWVPLGNQADLFPEGAIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDITLLEPVEGEAAEELSRCFSPGVIEVQEIQGKKVARVANPRLDTFSREVFRNEKLKKVVRLARVRDHFIFSVESTGVLPPDVLVSEAIKVLMGKCQRFLDELDAVQMD", "length": 346, "header": "sp|Q32L22-1|RPAC1_BOVIN Isoform 1 of DNA-directed RNA polymerases I and III subunit RPAC1 OS=Bos taurus OX=9913 GN=POLR1C PE=2 SV=1 CANONICAL=Q32L22-1" }, "locus": { "chromosome": "23", "start_pos": 17069166, "end_pos": 17062591, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025246.5", "url": "https://www.ensembl.org/id/ENSBTAT00000025246.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025246.3", "url": "https://www.ensembl.org/id/ENSBTAP00000025246.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ 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"description": "RNA Polymerase III Transcription Initiation From Type 1 Promoter" }, { "id": "R-BTA-76066", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76066", "resource": "Reactome", "description": "RNA Polymerase III Transcription Initiation From Type 2 Promoter" }, { "id": "R-BTA-76071", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76071", "resource": "Reactome", "description": "RNA Polymerase III Transcription Initiation From Type 3 Promoter" } ], "orthologs": [ { "uniprot_canonical_ac": "O15160-1", "protein_name": "DNA-directed RNA polymerases I and III subunit RPAC1", "gene_name": "POLR1C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q32L22", "url": "https://www.uniprot.org/uniprotkb/Q32L22" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 32, "end_pos": 34, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" }, { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L22-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 346, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L22-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L22" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 32, "end_pos": 34 }, { "start_pos": 96, "end_pos": 98 }, { "start_pos": 97, "end_pos": 99 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": 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}, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L40-1", "uniprot_ac": "Q32L40", "uniprot_id": "TCPA_BOVIN", "mass": { "chemical_mass": 60206.0, "monoisotopic_mass": 60206.0 }, "refseq": { "ac": "NP_001033175", "name": "T-complex protein 1 subunit alpha", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" }, "gene_names": [ { "name": "TCP1", "type": "recommended", "evidence": [ { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ] }, { "name": "CCT1", "type": "synonym", "evidence": [ { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ] }, { "name": "CCT", "type": "synonym", "evidence": [ { "id": "NP_001033175", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" } ] }, { "name": "TCP1", "type": "synonym", "evidence": [ { "id": "NP_001033175", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" } ] }, { "name": "TRiC", "type": "synonym", "evidence": [ { "id": "NP_001033175", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" } ] } ], "protein_names": [ { "name": "T-complex protein 1 subunit alpha", "type": "recommended", "evidence": [ { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40/entry#names_and_taxonomy" } ] }, { "name": "3.6.1.-", "type": "synonym", "evidence": [ { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40/entry#names_and_taxonomy" } ] }, { "name": "CCT-alpha", "type": "synonym", "evidence": [ { "id": "NP_001033175", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" }, { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40/entry#names_and_taxonomy" } ] }, { "name": "T-complex protein 1 subunit alpha", "type": "synonym", "evidence": [ { "id": "NP_001033175", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" } ] }, { "name": "TCP-1-alpha", "type": "synonym", "evidence": [ { "id": "NP_001033175", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" }, { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40/entry#names_and_taxonomy" } ] }, { "name": "cytosolic chaperonin containing t-complex polypeptide 1", "type": "synonym", "evidence": [ { "id": "NP_001033175", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" } ] } ], "function": [ { "annotation": "Analysis of the formation of a stable complex between chaperonin-containing TCP-1 (CCT) and Hsc70", "evidence": [ { "database": "RefSeq", "id": "NP_001033175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" }, { "database": "PubMed", "id": "18660820", "url": "https://glygen.org/publication/PubMed/18660820" } ] }, { "annotation": "Antagonistic actions of PhLP3 and prefoldin serve to modulate CCT activity and play a key role in establishing a functional cytoskeleton in vivo", "evidence": [ { "database": "RefSeq", "id": "NP_001033175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" }, { "database": "PubMed", "id": "16415341", "url": "https://glygen.org/publication/PubMed/16415341" } ] }, { "annotation": "Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.", "evidence": [ { "database": "UniProtKB", "id": "Q32L40", "url": "https://www.uniprot.org/uniprotkb/Q32L40#function" }, { "database": "UniProtKB", "id": "P17987", "url": "https://www.uniprot.org/uniprotkb/P17987#function" } ] }, { "annotation": "Data show that chaperonin TRiC binding is specified by two short hydrophobic beta strands in the von Hippel-Lindau protein that, upon folding, become buried within the native structure [TRiC].", "evidence": [ { "database": "RefSeq", "id": "NP_001033175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" }, { "database": "PubMed", "id": "14636579", "url": "https://glygen.org/publication/PubMed/14636579" } ] }, { "annotation": "PrP oligomers and fibrils only partially prevent the reactivation of GAPDS upon the action of TRiC; chaperonin TRiC is blocked by native and glycated prion protein", "evidence": [ { "database": "RefSeq", "id": "NP_001033175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" }, { "database": "PubMed", "id": "32101762", "url": "https://glygen.org/publication/PubMed/32101762" } ] }, { "annotation": "Results indicate that the kinetic mechanism of the allosteric transitions of chaperonin containing t-complex polypeptide 1 (TCP-1) differs considerably from that of GroEL", "evidence": [ { "database": "RefSeq", "id": "NP_001033175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" }, { "database": "PubMed", "id": "12589746", "url": "https://glygen.org/publication/PubMed/12589746" } ] }, { "annotation": "The mammalian TRiC structure was determined at 4.7-A resolution.", "evidence": [ { "database": "RefSeq", "id": "NP_001033175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" }, { "database": "PubMed", "id": "20194787", "url": "https://glygen.org/publication/PubMed/20194787" } ] }, { "annotation": "Unlike GroEL, TRiC does not close its lid upon nucleotide binding, but instead responds to the trigonal-bipyramidal transition state of ATP hydrolysis.", "evidence": [ { "database": "RefSeq", "id": "NP_001033175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" }, { "database": "PubMed", "id": "12732144", "url": "https://glygen.org/publication/PubMed/12732144" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L40", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TCP1", "url": "https://www.uniprot.org/uniprotkb/Q32L40", "locus": { "chromosome": "9", "start_pos": 96044639, "end_pos": 96055563, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002829", "url": "https://www.ensembl.org/id/ENSBTAG00000002829" } ] } } ], "crossref": [ { "id": "Q32L40", "url": "https://alphafold.ebi.ac.uk/entry/Q32L40", "database": "AlphaFoldDB", "categories": [] }, { "id": "3.6.4.B10", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.4.B10&UniProtAcc=Q32L40", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd03335", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03335", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512043", "url": "https://www.ncbi.nlm.nih.gov/gene/512043", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "3IYG", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=3IYG&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "4B2T", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=4B2T&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "1872816", "url": 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"categories": [ "Protein Classification" ] }, { "id": "IPR027409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027410", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027410", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053374", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053374", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512043", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512043", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32L40", "url": "https://www.orthodb.org/?gene=Q32L40", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11353", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11353", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00003iyg", "url": "https://www.rcsb.org/structure/pdb_00003iyg", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00004b2t", "url": "https://www.rcsb.org/structure/pdb_00004b2t", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3IYG", "url": "https://www.rcsb.org/structure/3IYG", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4B2T", "url": "https://www.rcsb.org/structure/4B2T", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00118", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00118", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PR:Q32L40", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:Q32L40", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001033175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32L40", "url": "https://www.uniprot.org/uniprotkb/Q32L40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L40-1", "url": "https://www.uniprot.org/uniprotkb/Q32L40-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGPLSVFGDRSTGEAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVRYISENLIINTDELGRDCLINAAKTSMSSKVIGINGDFFANLVVDAVLAIKYTDIRGQPRYPVNSINVLKAHGRSQMESMLINGYALNCVVGSQGMPKRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYFVEAGAMAVRRVLKRDLKRIAKASGATVLSTLANLEGEETFEASMLGQAEEVVQERICDDELILIKNTKARTSASVILRGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLPVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLVNGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLIKLHPESKDDKHGGYEDAVHSGALDA", "length": 556, "header": "sp|Q32L40-1|TCPA_BOVIN Isoform 1 of T-complex protein 1 subunit alpha OS=Bos taurus OX=9913 GN=TCP1 PE=1 SV=1 CANONICAL=Q32L40-1" }, "isoforms": [ { "isoform_ac": "Q32L40-1", "url": "https://www.uniprot.org/uniprotkb/Q32L40/entry#Q32L40-1", "sequence": { "sequence": "MEGPLSVFGDRSTGEAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVRYISENLIINTDELGRDCLINAAKTSMSSKVIGINGDFFANLVVDAVLAIKYTDIRGQPRYPVNSINVLKAHGRSQMESMLINGYALNCVVGSQGMPKRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYFVEAGAMAVRRVLKRDLKRIAKASGATVLSTLANLEGEETFEASMLGQAEEVVQERICDDELILIKNTKARTSASVILRGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLPVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLVNGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLIKLHPESKDDKHGGYEDAVHSGALDA", "length": 556, "header": "sp|Q32L40-1|TCPA_BOVIN Isoform 1 of T-complex protein 1 subunit alpha OS=Bos taurus OX=9913 GN=TCP1 PE=1 SV=1 CANONICAL=Q32L40-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 181, "end_pos": 181, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q32L40", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ], "site_lbl": "Tyr181" }, { "start_pos": 551, "end_pos": 551, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32L40", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ], "site_lbl": "Ser551" }, { "start_pos": 6, "end_pos": 6, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32L40", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ], "site_lbl": "Ser6" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Transient kinetic analysis of ATP-induced allosteric transitions in the eukaryotic chaperonin containing TCP-1.", "journal": "Journal of molecular biology", "date": "2003-02-28", "authors": "Kafri Galit, Horovitz Amnon", "evidence": [ { "database": "RefSeq", "id": "NP_001033175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" } ], "reference": [ { "type": "PubMed", "id": "12589746", "url": "https://glygen.org/publication/PubMed/12589746" } ] }, { "title": "Closing the folding chamber of the eukaryotic chaperonin requires the transition state of ATP hydrolysis.", "journal": "Cell", "date": "2003-05-02", "authors": "Meyer Anne S, Gillespie Joel R, Walther Dirk, Millet Ian S, Doniach Sebastian, Frydman Judith", "evidence": [ { "database": "RefSeq", "id": "NP_001033175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" } ], "reference": [ { "type": "PubMed", "id": "12732144", "url": "https://glygen.org/publication/PubMed/12732144" } ] }, { "title": "Tumorigenic mutations in VHL disrupt folding in vivo by interfering with chaperonin binding.", "journal": "Molecular cell", "date": "2003-11", "authors": "Feldman Douglas E, Spiess Christoph, Howard Daniel E, Frydman Judith", "evidence": [ { "database": "RefSeq", "id": "NP_001033175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" } ], "reference": [ { "type": "PubMed", "id": "14636579", "url": "https://glygen.org/publication/PubMed/14636579" } ] }, { "title": "PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Stirling PC, Cuellar J, Alfaro GA, El Khadali F, Beh CT, Valpuesta JM, Melki R, Leroux MR", "evidence": [ { "database": "RefSeq", "id": "NP_001033175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" } ], "reference": [ { "type": "PubMed", "id": "16415341", "url": "https://glygen.org/publication/PubMed/16415341" } ] }, { "title": "The structure of CCT-Hsc70 NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin.", "journal": "Nature structural & molecular biology", "date": "2008-08", "authors": "Cu\u00e9llar Jorge, Mart\u00edn-Benito Jaime, Scheres Sjors H W, Sousa Rui, Moro Fernando, L\u00f3pez-Vi\u00f1as Eduardo, G\u00f3mez-Puertas Paulino, Muga Arturo, Carrascosa Jos\u00e9 L, Valpuesta Jos\u00e9 M", "evidence": [ { "database": "RefSeq", "id": "NP_001033175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" } ], "reference": [ { "type": "PubMed", "id": "18660820", "url": "https://glygen.org/publication/PubMed/18660820" } ] }, { "title": "4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2010-03-16", "authors": "Cong Yao, Baker Matthew L, Jakana Joanita, Woolford David, Miller Erik J, Reissmann Stefanie, Kumar Ramya N, Redding-Johanson Alyssa M, Batth Tanveer S, Mukhopadhyay Aindrila, Ludtke Steven J, Frydman Judith, Chiu Wah", "evidence": [ { "database": "RefSeq", "id": "NP_001033175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" } ], "reference": [ { "type": "PubMed", "id": "20194787", "url": "https://glygen.org/publication/PubMed/20194787" } ] }, { "title": "HLA-DO Modulates the Diversity of the MHC-II Self-peptidome.", "journal": "Molecular & cellular proteomics : MCP", "date": "2019-03", "authors": "Nanaware Padma P, Jurewicz Mollie M, Leszyk John D, Shaffer Scott A, Stern Lawrence J", "evidence": [ { "database": "IEDB", "id": "689728", "url": "https://www.iedb.org/epitope/689728" }, { "database": "IEDB", "id": "1872816", "url": "https://www.iedb.org/epitope/1872816" }, { "database": "IEDB", "id": "1872817", "url": "https://www.iedb.org/epitope/1872817" } ], "reference": [ { "type": "PubMed", "id": "30573663", "url": "https://glygen.org/publication/PubMed/30573663" } ] }, { "title": "The chaperonin TRiC is blocked by native and glycated prion protein.", "journal": "Archives of biochemistry and biophysics", "date": "2020-04-15", "authors": "Kudryavtseva S S, Stroylova Y Y, Kurochkina L P, Muronetz V I", "evidence": [ { "database": "RefSeq", "id": "NP_001033175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033175" } ], "reference": [ { "type": "PubMed", "id": "32101762", "url": "https://glygen.org/publication/PubMed/32101762" } ] } ], "pathway": [ { "id": "bta:512043", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512043", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q32L40", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q32L40", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ], "pmid": "" }, { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "Q32L40", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q32L40", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ], "pmid": "" }, { "name": "ATP-dependent protein folding chaperone", "id": "GO:0140662", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140662", "evidence": [ { "database": "UniProtKB", "id": "Q32L40", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "Q32L40", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ], "pmid": "" }, { "name": "chaperonin-containing T-complex", "id": "GO:0005832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005832", "evidence": [ { "database": "UniProtKB", "id": "Q32L40", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "Q32L40", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", 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"ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", 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"ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": 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"activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TBP1", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] } ] }, { "uniprot_ac": "Q2TBU9", "gene_name": 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} ], "crossref": [ { "id": "Q32L52", "url": "https://alphafold.ebi.ac.uk/entry/Q32L52", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001827", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001827", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505570", "url": "https://www.ncbi.nlm.nih.gov/gene/505570", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006594", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006594", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024964", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024964", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050618", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050618", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505570", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505570", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KMILWAQ", "url": "https://omabrowser.org/oma/group/KMILWAQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32L52", "url": "https://www.orthodb.org/?gene=Q32L52", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12864", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12864", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08513", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08513", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10607", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10607", 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taurus OX=9913 GN=GID8 PE=2 SV=1 CANONICAL=Q32L52-1" }, "isoforms": [ { "isoform_ac": "Q32L52-1", "url": "https://www.uniprot.org/uniprotkb/Q32L52/entry#Q32L52-1", "sequence": { "sequence": "MSYTEKPDEITKDEWMEKLNNLHVQRADMNRLIMNYLVTEGFKEAAEKFRMESGIEPSVDLETLDERIKIREMILKGQIQEAIALINSLHPELLDTNRYLYFHLQQQHLIELIRQRETEAALEFAQTQLAEQGEESRECLTEMERTLALLAFDNPEDSPFGDLLNMMQRQKVWSEVNQAVLDYENRESTPKLAKLLKLLLWAQNELDQKKVKYPKMTDLSKGVIEEPK", "length": 228, "header": "sp|Q32L52-1|GID8_BOVIN Isoform 1 of Glucose-induced degradation protein 8 homolog OS=Bos taurus OX=9913 GN=GID8 PE=2 SV=1 CANONICAL=Q32L52-1" }, "locus": { "chromosome": "13", "start_pos": 54468239, "end_pos": 54465371, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002387.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002387.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002387.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002387.4" } ] } } ], "glycosylation": [], "phosphorylation": [], 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"glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "E7FGY2-1", "protein_name": "Glucose-induced degradation protein 8-B homolog", "gene_name": "gid8b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMSYAEKPEDITRDEWMEKLNNVHIQRADMNRLIMNYLVTEGFKEAAEKFRMESGIEPSVDLDSLDERIKIREMVLKGQIQEAIALINSLHPELLDTNRYLYFHLQQQHLIELIRLRETEAALEFAQTQLAEQGEESRECLTEMERTLALLAFDNPEESPFGDLLNMMQRQKVWSEVNQAVLDYENRESTPKLAKLLKLLLWAQNELDQKKVKYPKMTDLSKGTIEDPK", "length": 229 }, "evidence": [ { "id": "Q32L52", "url": "https://omabrowser.org/oma/group/Q32L52/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3HGX7-1", "protein_name": "Glucose-induced degradation protein 8 homolog", "gene_name": "Gid8", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSYTEKPDEITKDEWMEKLNNLHVQRADMNRLIMNYLVTEGFKEAAEKFRMESGIEPSVDLETLDERIKIREMILKGQIQEAIALINSLHPELLDTNRYLYFHLQQQHLIELIRQRETEAALEFAQTQLAEQGEESRECLTEMERTLALLAFDSPEESPFGDLLHMMQRQKVWSEVNQAVLDYENRESTPKLAKLLKLLLWAQNELDQKKVKYPKMTDLSKGVIEEPK", "length": 228 }, "evidence": [ { "id": "Q32L52", "url": "https://omabrowser.org/oma/group/Q32L52/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q54X16-1", "protein_name": "Glucose-induced degradation protein 8 homolog", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSNSYSSNAQKKVISTSEWDDKLAEVNISKSDLNKLVMNYLVIEGYQEAAAKFQEESSTQTTVDLASIADRMAIRSAIQCGDVEKGIEIVNDLNPEILDTNPQLYFHLQQQKLIELIRKGMTAEALKFAQDELAPQGEENNKFLEELEKTISLLVFEDTAKSPLSSLLDHSQRQKTAGELNSAILLSQSQDKDPKLPTILKLLKWAQTQLDSKCIYPKITNTVTGEYE", "length": 228 }, "evidence": [ { "id": "Q32L52", "url": "https://omabrowser.org/oma/group/Q32L52/", "database": "OMA" } ], "glygen_name": "Cellular 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"MSLFRIFINQLEEDDEDMATSKKMITREEWEKKLNAVKLRKEDMNTLVMNFLVTEGYVEAAEKFQRESGTKPEIDLATITDRMAVKKAVQNGNVEDAIEKVNDLNPEILDTNPELFFHLQQQRLIELIRQGKTEEALEFAQEELAPRGEENQAFLEELEKTVALLVFDDASTCPVKELLDLSHRLKTASEVNAAILTSQSHEKDPKLPSLLKMLIWAQTQLDEKAVYPHINDLSTGKLEDPSE", "length": 243 }, "evidence": [ { "id": "Q32L52", "url": "https://omabrowser.org/oma/group/Q32L52/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9D7M1-1", "protein_name": "Glucose-induced degradation protein 8 homolog", "gene_name": "Gid8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSYAEKPDEITKDEWMEKLNNLHVQRADMNRLIMNYLVTEGFKEAAEKFRMESGIEPSVDLETLDERIKIREMILKGQIQEAIALINSLHPELLDTNRYLYFHLQQQHLIELIRQRETEAALEFAQTQLAEQGEESRECLTEMERTLALLAFDSPEESPFGDLLHMMQRQKVWSEVNQAVLDYENRESTPKLAKLLKLLLWAQNELDQKKVKYPKMTDLSKGVIEEPK", "length": 228 }, "evidence": [ { "id": "Q32L52", "url": "https://omabrowser.org/oma/group/Q32L52/", "database": "OMA" } ], "glygen_name": 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"MSYNEKSEAIIKEEWLQRLEQFPFKQADMNRLIMNYLVTEGFKEAAEKFQHEADLEPSVELSSLDGRILIREAVQAGRIEEATQLVNQLHPELLGSDRYLFFHLQQLQLIELIRAGKVEEALSFAQSKLSESGEEAMFELERTLALLAFEKPQESPFADLLEQSYRQKIASELNSAILRCEQSEDSTPKMMFLLKLILWAQSKLDSRSISYPKMKNLETAHLEPK", "length": 225 }, "evidence": [ { "id": "Q32L52", "url": "https://omabrowser.org/oma/group/Q32L52/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32L52", "url": "https://www.uniprot.org/uniprotkb/Q32L52" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q32L52", "url": "https://www.uniprot.org/uniprotkb/Q32L52" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", 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"proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q32L52", "url": "https://www.uniprot.org/uniprotkb/Q32L52" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "Q32L52", "url": "https://www.uniprot.org/uniprotkb/Q32L52" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "Q32L52", "url": "https://www.uniprot.org/uniprotkb/Q32L52" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": 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"type": "synonym", "evidence": [ { "id": "NP_001033143", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033143" } ] } ], "function": [ { "annotation": "Required for correct progression through G2 phase of the cell cycle and entry into mitosis. 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"MSHGPRQPGAATAPAGGKTPGQHGAFVVAVKQERSEGSRAGEKGPQEEEPVKKRGWPKGKKRKKILPNGPKAPVTGYVRFLNERREQIRTRHPDLPFPEITKMLGAEWSKLQPAEKQRYLDEAEKEKQQYLKELWAYQQSEAYKVCTEKIQENKIKKEDSSSGLMNTLLNGHKGVDCDGFSTFDVPIFTEEFLDQNKAREAELRRLRKMNVAFEEQNAVLQRHTQSMSSARERLEQELALEERRTLALQQQLQAVRQALTASFASLPVPGTGETPTLGTLDFYMARLHGAIERDPAQHERLIARVKEILARVASEHL", "length": 317 }, "evidence": [ { "id": "Q32L68", "url": "https://omabrowser.org/oma/group/Q32L68/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "R4GGQ7-1", "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related", "gene_name": "HMG20B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": 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"http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13619:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09139", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09139", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073242", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16229", "url": "https://www.rhea-db.org/rhea/16229", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32L81", "url": "https://www.uniprot.org/uniprotkb/Q32L81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L81-1", "url": "https://www.uniprot.org/uniprotkb/Q32L81-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALQALQSSGVAFRKILSHFPEELSLAFAYGSGVYRQAGPSSDQKNAMLDFVFTVDDPWHSKNLKRNWNHYSFLKVLGPRIITAVQNNYGAGVYYNTLITCDGRLIKYGVISTSVLIEDLLNWNNLYIAGRLQKPVKIVAMNEDVALRSALDQNLKSAVTAAFLMLPESFSEEDLFTEIAGLSYSGDFRMVVGEDKAKVLNIVKPNMAHFRELYGSILQESPQVVYKAQQGSLEIDKSPEGQFTQLMTLPKTLQQQINHIMDPPGKNRDVEETLLQVAHDPDCGDVVRLGLAAIVRPSSMRQSTKGIFTAGLKKSVVYSSLKLHKMWKGWVRKTS", "length": 335, "header": "sp|Q32L81-1|TAM41_BOVIN Isoform 1 of Phosphatidate cytidylyltransferase, mitochondrial OS=Bos taurus OX=9913 GN=TAMM41 PE=2 SV=1 CANONICAL=Q32L81-1" }, "isoforms": [ { "isoform_ac": "Q32L81-1", "url": "https://www.uniprot.org/uniprotkb/Q32L81/entry#Q32L81-1", "sequence": { "sequence": "MALQALQSSGVAFRKILSHFPEELSLAFAYGSGVYRQAGPSSDQKNAMLDFVFTVDDPWHSKNLKRNWNHYSFLKVLGPRIITAVQNNYGAGVYYNTLITCDGRLIKYGVISTSVLIEDLLNWNNLYIAGRLQKPVKIVAMNEDVALRSALDQNLKSAVTAAFLMLPESFSEEDLFTEIAGLSYSGDFRMVVGEDKAKVLNIVKPNMAHFRELYGSILQESPQVVYKAQQGSLEIDKSPEGQFTQLMTLPKTLQQQINHIMDPPGKNRDVEETLLQVAHDPDCGDVVRLGLAAIVRPSSMRQSTKGIFTAGLKKSVVYSSLKLHKMWKGWVRKTS", "length": 335, "header": "sp|Q32L81-1|TAM41_BOVIN Isoform 1 of Phosphatidate cytidylyltransferase, mitochondrial OS=Bos taurus OX=9913 GN=TAMM41 PE=2 SV=1 CANONICAL=Q32L81-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:514330", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514330", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q32L81", "url": "https://www.uniprot.org/uniprotkb/Q32L81" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q32L81", "url": "https://www.uniprot.org/uniprotkb/Q32L81" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphatidate cytidylyltransferase activity", "id": "GO:0004605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004605", "evidence": [ { "database": "UniProtKB", "id": "Q32L81", "url": "https://www.uniprot.org/uniprotkb/Q32L81" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "CDP-diacylglycerol biosynthetic process", "id": "GO:0016024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016024", "evidence": [ { "database": "UniProtKB", "id": "Q32L81", "url": "https://www.uniprot.org/uniprotkb/Q32L81" } ], "pmid": "" }, { "name": "cardiolipin biosynthetic process", "id": "GO:0032049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032049", "evidence": [ { "database": "UniProtKB", "id": "Q32L81", "url": "https://www.uniprot.org/uniprotkb/Q32L81" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16229", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0JNC1-1", "A0AAA9SJE4-1", "F1MZC5-1", "Q32L81-1" ], "evidence": [ { "id": "16229", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16229" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SJE4", "gene_name": "CDS1", "activity": [ { "ec_number": "2.7.7.41", "activity": "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate.", "evidence": [ { "id": "A0AAA9SJE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE4" } ] }, { "ec_number": "2.7.7.41", "activity": "", "evidence": [ { "id": "A0AAA9SJE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJE4" } ] } ] }, { "uniprot_ac": "A0JNC1", "gene_name": "CDS2", "activity": [ { "ec_number": "2.7.7.41", "activity": "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate.", "evidence": [ { "id": "A0JNC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNC1" } ] }, { "ec_number": "2.7.7.41", "activity": "", "evidence": [ { "id": "A0JNC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNC1" } ] } ] }, { "uniprot_ac": "F1MZC5", "gene_name": "TAMM41", "activity": [ { "ec_number": "2.7.7.41", "activity": "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate.", "evidence": [ { "id": "F1MZC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZC5" } ] }, { "ec_number": "2.7.7.41", "activity": "", "evidence": [ { "id": "F1MZC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZC5" } ] } ] }, { "uniprot_ac": "Q32L81", "gene_name": "TAMM41", "activity": [ { "ec_number": "2.7.7.41", "activity": "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate.", "evidence": [ { "id": "Q32L81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L81" } ] }, { "ec_number": "2.7.7.41", "activity": "", "evidence": [ { "id": "Q32L81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L81" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L81-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 335, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L81-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L81" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.7.41", "ec_name": "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate.", "evidence": [ { "id": "2.7.7.41", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.41" }, { "id": "2.7.7.41", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.7.41" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { 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"total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L85-1", "uniprot_ac": "Q32L85", "uniprot_id": "SAYS1_BOVIN", "mass": { "chemical_mass": 21512.0, "monoisotopic_mass": 21512.0 }, "refseq": { "ac": "NP_001033314", "name": "SAYSvFN domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033314" }, "gene_names": [ { "name": "SAYSD1", "type": "recommended", "evidence": [ { "id": "Q32L85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L85" } ] }, { "name": "C23H6orf64", "type": "synonym", "evidence": [ { "id": "NP_001033314", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033314" } ] }, { "name": "C6orf64", "type": "synonym", "evidence": [ { "id": "NP_001033314", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033314" } ] }, { "name": "SAYSD1", "type": "synonym", "evidence": [ { "id": "NP_001033314", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033314" } ] } ], "protein_names": [ { "name": "SAYSvFN domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q32L85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L85/entry#names_and_taxonomy" } ] }, { "name": "SAYSvFN domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001033314", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033314" } ] }, { "name": "uncharacterized protein C6orf64 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033314", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033314" } ] } ], "function": [ { "annotation": "Ufmylation 'reader' component of a translocation-associated quality control pathway, a mechanism that takes place when a ribosome has stalled during translation, and which is required to degrade clogged substrates. Specifically recognizes and binds ufmylated ribosomes when a ribosome has stalled, promoting the transport of stalled nascent chain via the TRAPP complex to lysosomes for degradation.", "evidence": [ { "database": "UniProtKB", "id": "Q32L85", "url": "https://www.uniprot.org/uniprotkb/Q32L85#function" }, { "database": "UniProtKB", "id": "Q9NPB0", "url": "https://www.uniprot.org/uniprotkb/Q9NPB0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L85", "url": "https://www.uniprot.org/uniprotkb/Q32L85" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SAYSD1", "url": "https://www.uniprot.org/uniprotkb/Q32L85", "locus": { "chromosome": "23", "start_pos": 12969790, "end_pos": 12976488, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001074", "url": "https://www.ensembl.org/id/ENSBTAG00000001074" } ] } } ], "crossref": [ { "id": "Q32L85", "url": "https://alphafold.ebi.ac.uk/entry/Q32L85", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001074", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001074", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618888", "url": "https://www.ncbi.nlm.nih.gov/gene/618888", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618888", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618888", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LPWWTHY", "url": "https://omabrowser.org/oma/group/LPWWTHY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32L85", "url": "https://www.orthodb.org/?gene=Q32L85", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13527", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13527", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13527:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13527:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10260", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10260", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033314", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32L85", "url": "https://www.uniprot.org/uniprotkb/Q32L85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L85-1", "url": "https://www.uniprot.org/uniprotkb/Q32L85-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQRLAEFRAARKRAGLVAEPSASSQSTQTSGEKAEAATTPKAPSGWLKRFLVWKPRPPSAQAQPSLAQGAAWPRGLESQPPWSPAEEAPPPPQPPPPQPLTPRDRSLLTSVTLLKVLLWLVLLGLFVELEFGLAYFVLSLFYWMYVGMRGPEEKMQGEKSAYSVFNPGCEAIQGSLTAEQLERELHLRPLPRR", "length": 194, "header": "sp|Q32L85-1|SAYS1_BOVIN Isoform 1 of SAYSvFN domain-containing protein 1 OS=Bos taurus OX=9913 GN=SAYSD1 PE=2 SV=1 CANONICAL=Q32L85-1" }, "isoforms": [ { "isoform_ac": "Q32L85-1", "url": "https://www.uniprot.org/uniprotkb/Q32L85/entry#Q32L85-1", "sequence": { "sequence": "MEQRLAEFRAARKRAGLVAEPSASSQSTQTSGEKAEAATTPKAPSGWLKRFLVWKPRPPSAQAQPSLAQGAAWPRGLESQPPWSPAEEAPPPPQPPPPQPLTPRDRSLLTSVTLLKVLLWLVLLGLFVELEFGLAYFVLSLFYWMYVGMRGPEEKMQGEKSAYSVFNPGCEAIQGSLTAEQLERELHLRPLPRR", "length": 194, "header": "sp|Q32L85-1|SAYS1_BOVIN Isoform 1 of SAYSvFN domain-containing protein 1 OS=Bos taurus OX=9913 GN=SAYSD1 PE=2 SV=1 CANONICAL=Q32L85-1" }, "locus": { "chromosome": "23", "start_pos": 12976377, "end_pos": 12970005, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001425.5", "url": "https://www.ensembl.org/id/ENSBTAT00000001425.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001425.4", "url": "https://www.ensembl.org/id/ENSBTAP00000001425.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618888", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618888", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B0F2-1", "protein_name": "SAYSVFN motif domain containing 1", "gene_name": "SAYSD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEQRLAEFRATRKRAGLAAEPTTSSQSAQTSGQKAEAAATPKAAPGWLKRFLAWKPRPASAQTQPSLTQGATPPPRTPARTPAQPPAPAPAPAPAPAPAPAPGDQSLLTNIGFLKGLLWLVLLGLFVELEFGLAYFVLSLFYWMYVGMRGPEERTEGEKSAYSVFNPGCEAIQGTLSAEQLERELHLRPMEAAG", "length": 194 }, "evidence": [ { "id": "Q32L85", "url": "https://omabrowser.org/oma/group/Q32L85/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3I2N6-1", "protein_name": "SAYSvFN domain-containing protein 1", "gene_name": "Saysd1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEQRLAEFREARKRAGLVAQPSTASQGEQPSAEKAVAAAATPKTAPSWLRRFLTWKASPAITRARPNQAQEAAQQPPQSAAVPLISSQRQSLLTNITFLKVLLWLVLLGLFVELEFGLAYFVLSMFYWMYVGTRNPEEKKEGEKSAYSVFNPGCEAIQGTLTAEQLERELQLRPPLGR", "length": 178 }, "evidence": [ { "id": "Q32L85", "url": "https://omabrowser.org/oma/group/Q32L85/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8K190-1", "protein_name": "SAYSvFN 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"Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "rescue of stalled ribosome", "id": "GO:0072344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072344", "evidence": [ { "database": "UniProtKB", "id": "Q32L85", "url": "https://www.uniprot.org/uniprotkb/Q32L85" } ], "pmid": "" }, { "name": "protein quality control for misfolded or incompletely synthesized proteins", "id": "GO:0006515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006515", "evidence": [ { "database": "UniProtKB", "id": "Q32L85", "url": "https://www.uniprot.org/uniprotkb/Q32L85" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q32L85", "url": "https://www.uniprot.org/uniprotkb/Q32L85" } ], "pmid": "" }, { "name": "endoplasmic reticulum 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"pdb_chain": "global", "start_pos": 1, "end_pos": 194, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L85-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L85" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32L93-1", "uniprot_ac": "Q32L93", "uniprot_id": "GMPR2_BOVIN", "mass": { "chemical_mass": 38033.0, "monoisotopic_mass": 38033.0 }, "refseq": { "ac": "NP_001033208", "name": "GMP reductase 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033208" }, "gene_names": [ { "name": "GMPR2", "type": "recommended", "evidence": [ { "id": "Q32L93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L93" } ] }, { "name": "GMPR 2", "type": "synonym", "evidence": [ { "id": "NP_001033208", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033208" } ] }, { "name": "GMPR2", "type": "synonym", "evidence": [ { "id": "NP_001033208", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033208" } ] } ], "protein_names": [ { "name": "GMP reductase 2", "type": "recommended", "evidence": [ { "id": "Q32L93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L93/entry#names_and_taxonomy" } ] }, { "name": "1.7.1.7", "type": "synonym", "evidence": [ { "id": "Q32L93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L93/entry#names_and_taxonomy" } ] }, { "name": "GMP reductase 2 (Guanosine 5-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2)", "type": "synonym", "evidence": [ { "id": "NP_001033208", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033208" } ] }, { "name": "GMP reductase 2", "type": "synonym", "evidence": [ { "id": "NP_001033208", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033208" } ] }, { "name": "GMPR 2", "type": "synonym", "evidence": [ { "id": "Q32L93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L93/entry#names_and_taxonomy" } ] }, { "name": "Guanosine 5'-monophosphate oxidoreductase 2", "type": "synonym", "evidence": [ { "id": "Q32L93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L93/entry#names_and_taxonomy" } ] }, { "name": "Guanosine monophosphate reductase 2", "type": "synonym", "evidence": [ { "id": "Q32L93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L93/entry#names_and_taxonomy" } ] }, { "name": "guanosine 5'-monophosphate oxidoreductase 2", "type": "synonym", "evidence": [ { "id": "NP_001033208", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033208" } ] } ], "function": [ { "annotation": "Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (Probable). Plays a role in modulating cellular differentiation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32L93", "url": "https://www.uniprot.org/uniprotkb/Q32L93#function" }, { "database": "HAMAP", "id": "MF_03195", "url": "https://hamap.expasy.org/signature/MF_03195" }, { "database": "UniProtKB", "id": "Q9P2T1", "url": "https://www.uniprot.org/uniprotkb/Q9P2T1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32L93", "url": "https://www.uniprot.org/uniprotkb/Q32L93" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GMPR2", "url": "https://www.uniprot.org/uniprotkb/Q32L93", "locus": { "chromosome": "10", "start_pos": 20927368, "end_pos": 20936187, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002715", "url": "https://www.ensembl.org/id/ENSBTAG00000002715" } ] } } ], "crossref": [ { "id": "Q32L93", "url": "https://alphafold.ebi.ac.uk/entry/Q32L93", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00381", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00381", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515837", "url": "https://www.ncbi.nlm.nih.gov/gene/515837", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001093", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001093", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050139", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050139", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515837", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515837", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32L93", "url": "https://www.orthodb.org/?gene=Q32L93", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43170", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43170", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43170:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43170:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00478", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00478", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033208", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17185", "url": "https://www.rhea-db.org/rhea/17185", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32L93", "url": "https://www.uniprot.org/uniprotkb/Q32L93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32L93-1", "url": "https://www.uniprot.org/uniprotkb/Q32L93-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPHIDNDVKLDFKDVLLRPKRSTLKSRSEVDLTRSFAFRNSKQMYTGIPIIAANMDTVGTFEMAKVLCKFSLFTAVHKHYSLEQWKEFASQNPDCLEHLAASSGTGSSDFEQLEQILNAIPQVKYVCLDVANGYSEHFVEFVKDVRKRFPEHTIMAGNVVTGEMVEELILSGADIIKVGIGPGSVCTTRKKTGVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVMLGGMLAGHSESGGELIERNGRKYKLFYGMSSEMAMKKYAGGVAEYRASEGKTVEVPFKGDVEHTIRDIIGGIRSTCTYVGAAKQKELSRRTTFIRVTQQVKPIFSDES", "length": 348, "header": "sp|Q32L93-1|GMPR2_BOVIN Isoform 1 of GMP reductase 2 OS=Bos taurus OX=9913 GN=GMPR2 PE=2 SV=1 CANONICAL=Q32L93-1" }, "isoforms": [ { "isoform_ac": "Q32L93-1", "url": "https://www.uniprot.org/uniprotkb/Q32L93/entry#Q32L93-1", "sequence": { "sequence": "MPHIDNDVKLDFKDVLLRPKRSTLKSRSEVDLTRSFAFRNSKQMYTGIPIIAANMDTVGTFEMAKVLCKFSLFTAVHKHYSLEQWKEFASQNPDCLEHLAASSGTGSSDFEQLEQILNAIPQVKYVCLDVANGYSEHFVEFVKDVRKRFPEHTIMAGNVVTGEMVEELILSGADIIKVGIGPGSVCTTRKKTGVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVMLGGMLAGHSESGGELIERNGRKYKLFYGMSSEMAMKKYAGGVAEYRASEGKTVEVPFKGDVEHTIRDIIGGIRSTCTYVGAAKQKELSRRTTFIRVTQQVKPIFSDES", "length": 348, "header": "sp|Q32L93-1|GMPR2_BOVIN Isoform 1 of GMP reductase 2 OS=Bos taurus OX=9913 GN=GMPR2 PE=2 SV=1 CANONICAL=Q32L93-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:515837", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515837", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "GMP metabolic process", "id": "GO:0046037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046037", "evidence": [ { "database": "UniProtKB", "id": "Q32L93", "url": "https://www.uniprot.org/uniprotkb/Q32L93" } ], "pmid": "" }, { "name": "purine nucleobase metabolic process", "id": "GO:0006144", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006144", "evidence": [ { "database": "UniProtKB", "id": "Q32L93", "url": "https://www.uniprot.org/uniprotkb/Q32L93" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q32L93", "url": "https://www.uniprot.org/uniprotkb/Q32L93" } ], "pmid": "" }, { "name": "GMP reductase activity", "id": "GO:0003920", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003920", "evidence": [ { "database": "UniProtKB", "id": "Q32L93", "url": "https://www.uniprot.org/uniprotkb/Q32L93" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "GMP reductase complex", "id": "GO:1902560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902560", "evidence": [ { "database": "UniProtKB", "id": "Q32L93", "url": "https://www.uniprot.org/uniprotkb/Q32L93" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17185", "name": "", "equation": "IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SH20-1", "F6R1R5-1", "Q32L93-1" ], "evidence": [ { "id": "17185", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17185" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SH20", "gene_name": "GMPR2", 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"MTKVKFIALKNYIKGGYPQEKDFETKEVDLDETLGNNQILVKLIYISVDPYVRGRMSEGKSYIDPFKIGEPIECGGVGKIEKSNCSKWKVGDYIANNQFPWKEKFVTDGNNPGCYKADKNAAPLPCYLSLLGMTGMTAYCGLTEIGEPKKGETLVVSAGSGAVGQIVGQVGKIIGCRVIGIAGSKEKCDFMTKELRFDVGINYKSPTYKDDIAKAVEKTGVDIYWENVGGEITDAVLPHLNKYARIPLCGVISSYNKTELDVGPRIQIYLLKSSAKMQGFIVFNYIDKFPAASKQLAEWYNQGKIKDQHSIKKGLDQVVPSFLSLFNSDHLGKMIIKIADE", "length": 341 }, "evidence": [ { "id": "Q32L99", "url": "https://omabrowser.org/oma/group/Q32L99/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5BK81-1", "protein_name": "Prostaglandin reductase 2", "gene_name": "Ptgr2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIIQRVVLDSRPGKNGNPVAENFRVEEVSLPDTINEGQVRVRTLYLSVDPYMRCKMNEETGADYLAPWQLAQVADGGGLGVIEESKHQKLAKGDFVTSFYWPWQTKAILDGNGLEKVDPQLVDGHLSYFLGAIGMPGLTSLIGVQEKGHVSAGSNQTMVVSGAAGACGSLAGQIGHLLGCSRVVGICGTHEKCLFLTSELGFDAAVNYKTGNVAEQLREACPDGVDVYFDNVGGDISNAVISQMNQNSHIILCGQISQYNKDVPYPPPLPPAVEAIQKERNITRERFMVLNYKDRFEPGILQLSQWFKEGKLKIKETVANGLENMGVAFQSMMTGGNIGKQIVRISEDSSP", "length": 351 }, "evidence": [ { "id": "Q32L99", "url": "https://omabrowser.org/oma/group/Q32L99/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8N8N7-1", "protein_name": "Prostaglandin reductase 2", "gene_name": "PTGR2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIVQRVVLNSRPGKNGNPVAENFRMEEVYLPDNINEGQVQVRTLYLSVDPYMRCRMNEDTGTDYITPWQLSQVVDGGGIGIIEESKHTNLTKGDFVTSFYWPWQTKVILDGNSLEKVDPQLVDGHLSYFLGAIGMPGLTSLIGIQEKGHITAGSNKTMVVSGAAGACGSVAGQIGHFLGCSRVVGICGTHEKCILLTSELGFDAAINYKKDNVAEQLRESCPAGVDVYFDNVGGNISDTVISQMNENSHIILCGQISQYNKDVPYPPPLSPAIEAIQKERNITRERFLVLNYKDKFEPGILQLSQWFKEGKLKIKETVINGLENMGAAFQSMMTGGNIGKQIVCISEEISL", "length": 351 }, "evidence": [ { "id": "Q32L99", "url": "https://omabrowser.org/oma/group/Q32L99/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VDQ1-1", "protein_name": "Prostaglandin reductase 2", "gene_name": "Ptgr2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIIQRVVLNSRPGKNGNPVAENFRVEEFSLPDALNEGQVQVRTLYLSVDPYMRCKMNEDTGTDYLAPWQLAQVADGGGIGVVEESKHQKLTKGDFVTSFYWPWQTKAILDGNGLEKVDPQLVDGHLSYFLGAIGMPGLTSLIGVQEKGHISAGSNQTMVVSGAAGACGSLAGQIGHLLGCSRVVGICGTQEKCLFLTSELGFDAAVNYKTGNVAEQLREACPGGVDVYFDNVGGDISNAVISQMNENSHIILCGQISQYSNDVPYPPPLPPAVEAIRKERNITRERFTVLNYKDKFEPGILQLSQWFKEGKLKVKETMAKGLENMGVAFQSMMTGGNVGKQIVCISEDSSL", "length": 351 }, "evidence": [ { "id": "Q32L99", "url": "https://omabrowser.org/oma/group/Q32L99/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32L99", "url": "https://www.uniprot.org/uniprotkb/Q32L99" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "prostaglandin metabolic process", "id": "GO:0006693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006693", "evidence": [ { "database": "UniProtKB", "id": "Q32L99", "url": "https://www.uniprot.org/uniprotkb/Q32L99" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "15-oxoprostaglandin 13-reductase [NAD(P)+] activity", "id": "GO:0047522", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047522", "evidence": [ { "database": "UniProtKB", "id": "Q32L99", "url": "https://www.uniprot.org/uniprotkb/Q32L99" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 281, "end_pos": 283, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11912", "name": "", "equation": "13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxoprostaglandin E2 + NADPH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3SZJ4-1", "Q24K16-1", "Q32L99-1" ], "evidence": [ { "id": "11912", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11912" } ] }, { "id": "11916", "name": "", "equation": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q32L99-1" ], "evidence": [ { "id": "11916", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11916" } ] }, { "id": "50584", "name": "", "equation": "13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N2W0-1", "Q3SZJ4-1", "Q24K16-1", "Q32L99-1" ], "evidence": [ { "id": "50584", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50584" } ] }, { "id": "50588", "name": "", "equation": "13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + NADPH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N2W0-1", "Q3SZJ4-1", "Q24K16-1", "Q32L99-1" ], "evidence": [ { "id": "50588", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50588" } ] }, { "id": "50592", "name": "", "equation": "13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + NADPH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N2W0-1", "Q3SZJ4-1", "Q24K16-1", "Q32L99-1" ], "evidence": [ { "id": "50592", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50592" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1N2W0", "gene_name": "PTGR1", "activity": [ { "ec_number": "1.3.1.74", "activity": "an n-alkanal + NADP(+) = an alk-2-enal + NADPH + H(+).", "evidence": [ { "id": "F1N2W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W0" } ] }, { "ec_number": "1.3.1.48", "activity": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+).", "evidence": [ { "id": "F1N2W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W0" } ] }, { "ec_number": "1.3.1.74", "activity": "", "evidence": [ { "id": "F1N2W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W0" } ] }, { "ec_number": "1.3.1.48", "activity": "", "evidence": [ { "id": "F1N2W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W0" } ] } ] }, { "uniprot_ac": "Q24K16", "gene_name": "PTGR3", "activity": [ { "ec_number": "1.3.1.48", "activity": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+).", "evidence": [ { "id": "Q24K16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K16" } ] }, { "ec_number": "1.3.1.48", "activity": "", "evidence": [ { "id": "Q24K16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K16" } ] } ] }, { "uniprot_ac": "Q32L99", "gene_name": "PTGR2", "activity": [ { "ec_number": "1.3.1.48", "activity": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+).", "evidence": [ { "id": "Q32L99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L99" } ] }, { "ec_number": "1.3.1.48", "activity": "", "evidence": [ { "id": "Q32L99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L99" } ] } ] }, { "uniprot_ac": "Q3SZJ4", "gene_name": "PTGR1", "activity": [ { "ec_number": "1.3.1.74", "activity": "an n-alkanal + NADP(+) = an alk-2-enal + NADPH + H(+).", "evidence": [ { "id": "Q3SZJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ4" } ] }, { "ec_number": "1.3.1.48", "activity": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+).", "evidence": [ { "id": "Q3SZJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32L99-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 351, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32L99-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32L99" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.3.1.48", "ec_name": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+).", "evidence": [ { "id": "1.3.1.48", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.48" }, { "id": "1.3.1.48", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.3.1.48" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 155, "end_pos": 157 }, { "start_pos": 281, "end_pos": 283 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LB1-1", "uniprot_ac": "Q32LB1", "uniprot_id": "TBPL1_BOVIN", "mass": { "chemical_mass": 20887.0, "monoisotopic_mass": 20887.0 }, "refseq": { "ac": "NP_001069758", "name": "TATA box-binding protein-like 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069758" }, "gene_names": [ { "name": "TBPL1", "type": "recommended", "evidence": [ { "id": "Q32LB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB1" } ] }, { "name": "TBPL1", "type": "synonym", "evidence": [ { "id": "NP_001069758", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069758" } ] }, { "name": "TLF", "type": "synonym", "evidence": [ { "id": "Q32LB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB1" } ] }, { "name": "TLP", "type": "synonym", "evidence": [ { "id": "Q32LB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB1" } ] }, { "name": "TRF2", "type": "synonym", "evidence": [ { "id": "Q32LB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB1" } ] }, { "name": "TRP", "type": "synonym", "evidence": [ { "id": "Q32LB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB1" } ] } ], "protein_names": [ { "name": "TATA box-binding protein-like 1", "type": "recommended", "evidence": [ { "id": "Q32LB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB1/entry#names_and_taxonomy" } ] }, { "name": "TATA box-binding protein related factor 2", "type": "synonym", "evidence": [ { "id": "NP_001069758", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069758" } ] }, { "name": "TATA box-binding protein-like 1", "type": "synonym", "evidence": [ { "id": "NP_001069758", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069758" } ] }, { "name": "TATA box-binding protein-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001069758", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069758" } ] }, { "name": "TATA box-binding protein-related factor 2", "type": "synonym", "evidence": [ { "id": "Q32LB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB1/entry#names_and_taxonomy" } ] }, { "name": "TBP-like 1", "type": "synonym", "evidence": [ { "id": "NP_001069758", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069758" }, { "id": "Q32LB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB1/entry#names_and_taxonomy" } ] }, { "name": "TBP-like factor", "type": "synonym", "evidence": [ { "id": "NP_001069758", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069758" }, { "id": "Q32LB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB1/entry#names_and_taxonomy" } ] }, { "name": "TBP-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001069758", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069758" } ] }, { "name": "TBP-related factor 2", "type": "synonym", "evidence": [ { "id": "NP_001069758", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069758" }, { "id": "Q32LB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB1/entry#names_and_taxonomy" } ] }, { "name": "TBP-related protein", "type": "synonym", "evidence": [ { "id": "NP_001069758", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069758" }, { "id": "Q32LB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32LB1", "url": "https://www.uniprot.org/uniprotkb/Q32LB1#function" }, { "database": "UniProtKB", "id": "A0ABI0NX06", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX06#function" }, { "database": "UniProtKB", "id": "ARBA00045512", "url": "https://www.uniprot.org/uniprotkb/ARBA00045512#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LB1", "url": "https://www.uniprot.org/uniprotkb/Q32LB1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBPL1", "url": "https://www.uniprot.org/uniprotkb/Q32LB1", "locus": { "chromosome": "9", "start_pos": 72151639, "end_pos": 72112239, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000035370", "url": "https://www.ensembl.org/id/ENSBTAG00000035370" } ] } } ], "crossref": [ { "id": "Q32LB1", "url": "https://alphafold.ebi.ac.uk/entry/Q32LB1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000035370", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000035370", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04517", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04517", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613818", "url": "https://www.ncbi.nlm.nih.gov/gene/613818", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000814", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000814", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012295", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012295", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613818", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613818", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NCEYEPE", "url": "https://omabrowser.org/oma/group/NCEYEPE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32LB1", "url": "https://www.orthodb.org/?gene=Q32LB1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10126", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10126", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069758", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NX06", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NX06-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX06-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LB1", "url": "https://www.uniprot.org/uniprotkb/Q32LB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LB1-1", "url": "https://www.uniprot.org/uniprotkb/Q32LB1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEIL", "length": 186, "header": "sp|Q32LB1-1|TBPL1_BOVIN Isoform 1 of TATA box-binding protein-like 1 OS=Bos taurus OX=9913 GN=TBPL1 PE=2 SV=1 CANONICAL=Q32LB1-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NX06-1", "url": "https://www.uniprot.org/uniprotkb/Q32LB1/entry#A0ABI0NX06-1", "sequence": { "sequence": "MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGILF", "length": 164, "header": "tr|A0ABI0NX06-1|A0ABI0NX06_BOVIN Computationally mapped isoform of TATA box-binding protein-like 1 OS=Bos taurus OX=9913 GN=TBPL1 PE=3 SV=1 CANONICAL=Q32LB1-1" }, "locus": { "chromosome": "9", "start_pos": 72147544, "end_pos": 72143822, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147083.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147083.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104445.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104445.1" } ] } }, { "isoform_ac": "Q32LB1-1", "url": "https://www.uniprot.org/uniprotkb/Q32LB1/entry#Q32LB1-1", "sequence": { "sequence": "MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEIL", "length": 186, "header": "sp|Q32LB1-1|TBPL1_BOVIN Isoform 1 of TATA box-binding protein-like 1 OS=Bos taurus OX=9913 GN=TBPL1 PE=2 SV=1 CANONICAL=Q32LB1-1" }, "locus": { "chromosome": "9", "start_pos": 72150727, "end_pos": 72143822, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000049877.5", "url": "https://www.ensembl.org/id/ENSBTAT00000049877.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046701.2", "url": "https://www.ensembl.org/id/ENSBTAP00000046701.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613818", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613818", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6A122-1", "protein_name": "TATA box-binding protein-like 1", "gene_name": "Tbpl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEIL", "length": 186 }, "evidence": [ { "id": "Q32LB1", "url": "https://omabrowser.org/oma/group/Q32LB1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S3R3-1", "protein_name": "TATA box-binding protein-like 1", "gene_name": "SLC2A12", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "IQLGTTRLRVRSLALLSGLRIRRCRELRCRLQTRLGSLCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEIL", "length": 207 }, "evidence": [ { "id": "Q32LB1", "url": "https://omabrowser.org/oma/group/Q32LB1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3IAV2-1", "protein_name": "TATA box-binding protein-like 1", "gene_name": "Tbpl1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQVYPFVFESRKEIL", "length": 186 }, "evidence": [ { "id": "Q32LB1", "url": "https://omabrowser.org/oma/group/Q32LB1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P13393-1", "protein_name": "TATA-box-binding protein", "gene_name": "SPT15", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MADEERLKEFKEANKIVFDPNTRQVWENQNRDGTKPATTFQSEEDIKRAAPESEKDTSATSGIVPTLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKIGFAAKFTDFKIQNIVGSCDVKFPIRLEGLAFSHGTFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREEIYQAFEAIYPVLSEFRKM", "length": 240 }, "evidence": [ { "id": "Q32LB1", "url": "https://omabrowser.org/oma/group/Q32LB1/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P26355-1", "protein_name": "TATA-box-binding protein", "gene_name": "tbpA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSTATTTSTPAQNVDLSKHPSGIIPTLQNIVSTVNMATELDLKAIALGARNAEYNPKRFAAVIMRIREPKTTALIFKSGKMVCTGAKSEDASRFAARKYARIIQKLDFPARFTDFKIQNIVGSCDVKFPIKLELLHNAHTSFTNYEPEIFPGLIYKMIQPKVVLLIFVSGKIVLTGAKVREEIYEAFENIYPVLSAFKKVNAITQ", "length": 205 }, "evidence": [ { "id": "Q32LB1", "url": "https://omabrowser.org/oma/group/Q32LB1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "P28148-1", "protein_name": "TATA-box-binding protein 2", "gene_name": "TBP2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MADQGTEGSQPVDLTKHPSGIVPTLQNIVSTVNLDCKLDLKAIALQARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEHLSKLAARKYARIVQKLGFPAKFKDFKIQNIVGSCDVKFPIRLEGLAYSHSAFSSYEPELFPGLIYRMKLPKIVLLIFVSGKIVITGAKMREETYTAFENIYPVLREFRKVQQ", "length": 200 }, "evidence": [ { "id": "Q32LB1", "url": "https://omabrowser.org/oma/group/Q32LB1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P62340-1", "protein_name": "TATA box-binding protein-like 1", "gene_name": "Tbpl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEIL", "length": 186 }, "evidence": [ { "id": "Q32LB1", "url": "https://omabrowser.org/oma/group/Q32LB1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P62380-1", "protein_name": "TATA box-binding protein-like 1", "gene_name": "TBPL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEIL", "length": 186 }, "evidence": [ { "id": "Q32LB1", "url": "https://omabrowser.org/oma/group/Q32LB1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5U385-1", "protein_name": "TATA box-binding protein-like 1", "gene_name": "tbpl1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEPSNDVALDIIVTNVVSVFRTRCHLNLRTIGLEGTNVIYKPEVGKVLMKLRKPRITASIWSSGKIICTGATSEEEAKLGARRLARCLQKMGFKVRFSDFKVVNVLAVCSMPFQIRLIEFTKNNRPIASYEPELHPAASYRIKNLRSTVQVFSTGNITVTGPNVQSVASAVEEIYPLLFECRKTLS", "length": 186 }, "evidence": [ { "id": "Q32LB1", "url": "https://omabrowser.org/oma/group/Q32LB1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9YGV8-1", "protein_name": "TATA box-binding protein-like 1", "gene_name": "TBPL1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKVICTGATSEEEAKFGARRLARCLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKTLRATLQIFSTGSITVTGPNVKAVASAVEQIYPFVFESRK", "length": 183 }, "evidence": [ { "id": "Q32LB1", "url": "https://omabrowser.org/oma/group/Q32LB1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32LB1", "url": "https://www.uniprot.org/uniprotkb/Q32LB1" } ], "pmid": "" }, { "name": "transcription factor TFIIA complex", "id": "GO:0005672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005672", "evidence": [ { "database": "UniProtKB", "id": "Q32LB1", "url": "https://www.uniprot.org/uniprotkb/Q32LB1" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32LB1", "url": "https://www.uniprot.org/uniprotkb/Q32LB1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "RNA polymerase II core promoter sequence-specific DNA binding", "id": "GO:0000979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000979", "evidence": [ { "database": "UniProtKB", "id": "Q32LB1", "url": "https://www.uniprot.org/uniprotkb/Q32LB1" } ], "pmid": "" }, { "name": "RNA polymerase II general transcription initiation factor activity", "id": "GO:0016251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016251", "evidence": [ { "database": "UniProtKB", "id": "Q32LB1", "url": "https://www.uniprot.org/uniprotkb/Q32LB1" } ], "pmid": "" }, { "name": "general transcription initiation factor activity", "id": "GO:0140223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140223", "evidence": [ { "database": "UniProtKB", "id": "Q32LB1", "url": "https://www.uniprot.org/uniprotkb/Q32LB1" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q32LB1", "url": "https://www.uniprot.org/uniprotkb/Q32LB1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription initiation", "id": "GO:0006352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006352", "evidence": [ { "database": "UniProtKB", "id": "Q32LB1", "url": "https://www.uniprot.org/uniprotkb/Q32LB1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LB1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 186, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LB1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LB1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LB9-1", "uniprot_ac": "Q32LB9", "uniprot_id": "NOA1_BOVIN", "mass": { "chemical_mass": 77243.0, "monoisotopic_mass": 77243.0 }, "refseq": {}, "gene_names": [ { "name": "NOA1", "type": "recommended", "evidence": [ { "id": "Q32LB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB9" } ] } ], "protein_names": [ { "name": "Nitric oxide-associated protein 1", "type": "recommended", "evidence": [ { "id": "Q32LB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32LB9", "url": "https://www.uniprot.org/uniprotkb/Q32LB9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LB9", "url": "https://www.uniprot.org/uniprotkb/Q32LB9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NOA1", "url": "https://www.uniprot.org/uniprotkb/Q32LB9", "locus": {} } ], "crossref": [ { "id": "Q32LB9", "url": "https://alphafold.ebi.ac.uk/entry/Q32LB9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01855", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01855", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539773", "url": "https://www.ncbi.nlm.nih.gov/gene/539773", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052807", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052807", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539773", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539773", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32LB9", "url": "https://www.orthodb.org/?gene=Q32LB9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46406", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46406", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46406:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46406:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01926", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01926", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q32LB9", "url": "https://www.uniprot.org/uniprotkb/Q32LB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LB9-1", "url": "https://www.uniprot.org/uniprotkb/Q32LB9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLPAPLARRLLCGFLRGPTPIVTRNGVRETLLERRCATDYSSRHSAGLGRGLPRGATATGGNPGGADLEESFLFPEYVLDSESEATLQDQLRELQQRQEEEERRIEQQREERRQQKLGAGRRVHQVVGHPDPTVPPSGQNCSGCGAELHCQDPGVPGYLPSEKFNSAVAEEGGLERTVCQRCWLLVHHRRALRLQVSQGQFLELVSAALRRPEPALVLYMVDLLDLPDTLLPHLPALVGPKQLIVLGNKVDLLPQDTPNYRQRLRERLWDECIGAGLLPPRGYRRAQRSSGDRPRGGEDNANLPSKSSTVLRDVRLISAKTGYGVEELISALQRSWRYRGDVYLVGSTNAGKSTLFNTLLESDYCIAKGAEAIDRATISPWPGTTLNLLKFPICNPTPYRMFQRQKRLKRDATEAEEDLSQQEQNKLNLLKKHGYLVGRVGRTFSYSEAQKDKAAFEFDADSFAFDMGNEPVLAADKSTKRVELTPEDVKDAHWFYDTPGITKENCILSLLTEKEVNIVLPTHSIIPRTFMLKPGMVLFLGALGRIDFLKGNQSAWFTVVASNFLPVHITSLDKADTMYQKHAGHTLLKVPVGGEERMAGFPPLVAEDITLDEGLGESEAVADIKLSSAGWVAVTPQFKDTLTLRGYTPQGTVLTVRRPLLPHIVNIKGKRIKGSVAYKTKRPPALMYNLQKKR", "length": 694, "header": "sp|Q32LB9-1|NOA1_BOVIN Isoform 1 of Nitric oxide-associated protein 1 OS=Bos taurus OX=9913 GN=NOA1 PE=2 SV=1 CANONICAL=Q32LB9-1" }, "isoforms": [ { "isoform_ac": "Q32LB9-1", "url": "https://www.uniprot.org/uniprotkb/Q32LB9/entry#Q32LB9-1", "sequence": { "sequence": "MLPAPLARRLLCGFLRGPTPIVTRNGVRETLLERRCATDYSSRHSAGLGRGLPRGATATGGNPGGADLEESFLFPEYVLDSESEATLQDQLRELQQRQEEEERRIEQQREERRQQKLGAGRRVHQVVGHPDPTVPPSGQNCSGCGAELHCQDPGVPGYLPSEKFNSAVAEEGGLERTVCQRCWLLVHHRRALRLQVSQGQFLELVSAALRRPEPALVLYMVDLLDLPDTLLPHLPALVGPKQLIVLGNKVDLLPQDTPNYRQRLRERLWDECIGAGLLPPRGYRRAQRSSGDRPRGGEDNANLPSKSSTVLRDVRLISAKTGYGVEELISALQRSWRYRGDVYLVGSTNAGKSTLFNTLLESDYCIAKGAEAIDRATISPWPGTTLNLLKFPICNPTPYRMFQRQKRLKRDATEAEEDLSQQEQNKLNLLKKHGYLVGRVGRTFSYSEAQKDKAAFEFDADSFAFDMGNEPVLAADKSTKRVELTPEDVKDAHWFYDTPGITKENCILSLLTEKEVNIVLPTHSIIPRTFMLKPGMVLFLGALGRIDFLKGNQSAWFTVVASNFLPVHITSLDKADTMYQKHAGHTLLKVPVGGEERMAGFPPLVAEDITLDEGLGESEAVADIKLSSAGWVAVTPQFKDTLTLRGYTPQGTVLTVRRPLLPHIVNIKGKRIKGSVAYKTKRPPALMYNLQKKR", "length": 694, "header": "sp|Q32LB9-1|NOA1_BOVIN Isoform 1 of Nitric oxide-associated protein 1 OS=Bos taurus OX=9913 GN=NOA1 PE=2 SV=1 CANONICAL=Q32LB9-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 133, "start_aa": "Thr", "end_pos": 133, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr133", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 635, "start_aa": "Thr", "end_pos": 635, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr635", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 77, "end_pos": 77, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q32LB9", "url": "https://www.uniprot.org/uniprotkb/Q32LB9" } ], "site_lbl": "Tyr77" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539773", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539773", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q32LB9", "url": "https://www.uniprot.org/uniprotkb/Q32LB9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q32LB9", "url": "https://www.uniprot.org/uniprotkb/Q32LB9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q32LB9", "url": "https://www.uniprot.org/uniprotkb/Q32LB9" } ], "pmid": "" }, { "name": "mitochondrion organization", "id": "GO:0007005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007005", "evidence": [ { "database": "UniProtKB", "id": "Q32LB9", "url": "https://www.uniprot.org/uniprotkb/Q32LB9" } ], "pmid": "" }, { "name": "mitochondrial ribosome assembly", "id": "GO:0061668", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061668", "evidence": [ { "database": "UniProtKB", "id": "Q32LB9", "url": "https://www.uniprot.org/uniprotkb/Q32LB9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 552, "end_pos": 554, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LB9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 694, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LB9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LB9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32LB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LB9" }, { "id": "PRU01058", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01058" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CP-type G", "eco_id": "ECO_0000255", "start_pos": 202, "end_pos": 504, "start_aa": "Leu", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 133, 635 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 77 ], "sequon_annotation_sites": [ { "start_pos": 140, "end_pos": 142 }, { "start_pos": 552, "end_pos": 554 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LC1-1", "uniprot_ac": "Q32LC1", "uniprot_id": "RPP38_BOVIN", "mass": { "chemical_mass": 31354.0, "monoisotopic_mass": 31354.0 }, "refseq": { "ac": "NP_001033174", "name": "ribonuclease P protein subunit p38", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033174" }, "gene_names": [ { "name": "RPP38", "type": "recommended", "evidence": [ { "id": "Q32LC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC1" } ] }, { "name": "RPP38", "type": "synonym", "evidence": [ { "id": "NP_001033174", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033174" } ] } ], "protein_names": [ { "name": "Ribonuclease P protein subunit p38", "type": "recommended", "evidence": [ { "id": "Q32LC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC1/entry#names_and_taxonomy" } ] }, { "name": "RNaseP protein p38", "type": "synonym", "evidence": [ { "id": "NP_001033174", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033174" }, { "id": "Q32LC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC1/entry#names_and_taxonomy" } ] }, { "name": "ribonuclease P protein subunit p38", "type": "synonym", "evidence": [ { "id": "NP_001033174", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033174" } ] }, { "name": "ribonuclease P/MRP 38 subunit", "type": "synonym", "evidence": [ { "id": "NP_001033174", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033174" } ] }, { "name": "ribonuclease P/MRP 38kDa subunit", "type": "synonym", "evidence": [ { "id": "NP_001033174", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033174" } ] } ], "function": [ { "annotation": "Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.", "evidence": [ { "database": "UniProtKB", "id": "Q32LC1", "url": "https://www.uniprot.org/uniprotkb/Q32LC1#function" }, { "database": "UniProtKB", "id": "P78345", "url": "https://www.uniprot.org/uniprotkb/P78345#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LC1", "url": "https://www.uniprot.org/uniprotkb/Q32LC1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPP38", "url": "https://www.uniprot.org/uniprotkb/Q32LC1", "locus": { "chromosome": "13", "start_pos": 29691816, "end_pos": 29673551, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000063884", "url": "https://www.ensembl.org/id/ENSBTAG00000063884" } ] } } ], "crossref": [ { "id": "Q32LC1", "url": "https://alphafold.ebi.ac.uk/entry/Q32LC1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007702", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007702", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511723", "url": "https://www.ncbi.nlm.nih.gov/gene/511723", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042848", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042848", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511723", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511723", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NQQVSGW", "url": "https://omabrowser.org/oma/group/NQQVSGW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32LC1", "url": "https://www.orthodb.org/?gene=Q32LC1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46948", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46948", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46948:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46948:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01248", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01248", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001033174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033174", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LC1", "url": "https://www.uniprot.org/uniprotkb/Q32LC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LC1-1", "url": "https://www.uniprot.org/uniprotkb/Q32LC1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAPQAPGRGSVRKTRPLPVKTSLNNPYSICWGVLDREDMHFILQTLEDRIQSLGLQKIEDRKRKKKQPPLKKQSGDTSSIDVDTGEDLKKEKPKGDAQASGWTPVDVRKQLAIGINEVTRALERNELLLALACKSAKPAIVTSHLVQLSVSRGVPACQVPRLSERLAPVLGLKCVLALGFKRNTTAFGEELRAILPRVPRLNVAWLQDALEDPRENLQTESLESQDEEILDTSFEDLSKPKRKLAEGQQPVVLQPLKIKKLIPNPNKIRKPPKSKRTASK", "length": 282, "header": "sp|Q32LC1-1|RPP38_BOVIN Isoform 1 of Ribonuclease P protein subunit p38 OS=Bos taurus OX=9913 GN=RPP38 PE=2 SV=2 CANONICAL=Q32LC1-1" }, "isoforms": [ { "isoform_ac": "Q32LC1-1", "url": "https://www.uniprot.org/uniprotkb/Q32LC1/entry#Q32LC1-1", "sequence": { "sequence": "MAAAPQAPGRGSVRKTRPLPVKTSLNNPYSICWGVLDREDMHFILQTLEDRIQSLGLQKIEDRKRKKKQPPLKKQSGDTSSIDVDTGEDLKKEKPKGDAQASGWTPVDVRKQLAIGINEVTRALERNELLLALACKSAKPAIVTSHLVQLSVSRGVPACQVPRLSERLAPVLGLKCVLALGFKRNTTAFGEELRAILPRVPRLNVAWLQDALEDPRENLQTESLESQDEEILDTSFEDLSKPKRKLAEGQQPVVLQPLKIKKLIPNPNKIRKPPKSKRTASK", "length": 282, "header": "sp|Q32LC1-1|RPP38_BOVIN Isoform 1 of Ribonuclease P protein subunit p38 OS=Bos taurus OX=9913 GN=RPP38 PE=2 SV=2 CANONICAL=Q32LC1-1" }, "locus": { "chromosome": "13", "start_pos": 29682983, "end_pos": 29682138, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010127.6", "url": "https://www.ensembl.org/id/ENSBTAT00000010127.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010127.4", "url": "https://www.ensembl.org/id/ENSBTAP00000010127.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 12, "end_pos": 12, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LC1", "url": "https://www.uniprot.org/uniprotkb/Q32LC1" } ], "site_lbl": "Ser12" }, { "start_pos": 226, "end_pos": 226, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LC1", "url": "https://www.uniprot.org/uniprotkb/Q32LC1" } ], "site_lbl": "Ser226" }, { "start_pos": 235, "end_pos": 235, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LC1", "url": "https://www.uniprot.org/uniprotkb/Q32LC1" } ], "site_lbl": "Ser235" } ], "glycation": [], "keywords": [], "publication": [ { "title": "A whole-genome assembly of the domestic cow, Bos taurus.", "journal": "Genome Biol.", "date": "2009", "authors": "Zimin Aleksey V, Delcher Arthur L, Florea Liliana, Kelley David R, Schatz Michael C, Puiu Daniela, Hanrahan Finnian, Pertea Geo, Van Tassell Curtis P, Sonstegard Tad S, Mar\u00e7ais Guillaume, Roberts Michael, Subramanian Poorani, Yorke James A, Salzberg Steven L", "evidence": [ { "database": "UniProtKB", "id": "Q32LC1", "url": "https://www.uniprot.org/uniprotkb/Q32LC1" } ], "reference": [ { "type": "PubMed", "id": "19393038", "url": "https://glygen.org/publication/PubMed/19393038" } ] } ], "pathway": [ { "id": "bta:511723", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511723", "resource": "KEGG Pathway" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "F1QS85-1", "protein_name": "3.1.26.5", "gene_name": "rpp38", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSTPAKGATKKEKKKPIPVKTSLNNPYNIGWSDLLQKQHKHLILDTLKEKLSATGLRKERVSRFRDWGSRRRSRKKASKPTEEQNPASEPAESVQTPEPGWTNLALRKQLAIGINEVTKGLERNELSLVLVCNSVTPAHMTSHLIPLSKTRSVPACQVPGLSGSLSELLGLKCVLALGFRRGSEEFENTVRAITPMVPQLPVAWIQTDSTPTTKEKRTEIGQKRKLEELSSDASPLVLQPLKVKKIIPNPTKIRKPKLKKQKKVV", "length": 265 }, "evidence": [ { "id": "Q32LC1", "url": "https://omabrowser.org/oma/group/Q32LC1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "I3LCJ7-1", "protein_name": "Ribonuclease P/MRP subunit p38", "gene_name": "RPP38", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAAPQAPGRGSVRKTRPPPVKTSLNNPYATCWGTLGQEDMHFILQTLEVRFKSLGLRKVEDRKRKKKQPSLGKESGDTCGMAADTGQDLEEKRSEGDAQASGWTPAHVRKQLAIGVNEVTRALERNELLLVLACKSAKPAMVTAHLVQLSASRGVPAGQVPRLSERIAPVVGLKCILALGFRKNTTAFADEVSTIIPRVPPLNVPWLGDLQDTPEDPQENSETKSLESRDKEILETSFEDLSKPKRKLAEGQQAVVLQPLKIKKLIPNPNKIRKPPKSKKMASK", "length": 285 }, "evidence": [ { "id": "Q32LC1", "url": "https://omabrowser.org/oma/group/Q32LC1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P78345-1", "protein_name": "Ribonuclease P protein subunit p38", "gene_name": "RPP38", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAPQAPGRGSLRKTRPLVVKTSLNNPYIIRWSALESEDMHFILQTLEDRLKAIGLQKIEDKKKKNKTPFLKKESREKCSIAVDISENLKEKKTDAKQQVSGWTPAHVRKQLAIGVNEVTRALERRELLLVLVCKSVKPAMITSHLIQLSLSRSVPACQVPRLSERIAPVIGLKCVLALAFKKNTTDFVDEVRAIIPRVPSLSVPWLQDRIEDSGENLETEPLESQDRELLDTSFEDLSKPKRKLADGRQASVTLQPLKIKKLIPNPNKIRKPPKSKKATPK", "length": 283 }, "evidence": [ { "id": "Q32LC1", "url": "https://omabrowser.org/oma/group/Q32LC1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q497C2-1", "protein_name": "Ribonuclease P/MRP subunit p38", "gene_name": "Rpp38", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAPQAPKRGSIRKTRPLVVKTSLNNPYVISWSSLEREDMHFILQTLEDKFKSIGLQKIEDKKKRKAKQRGGLVGTSEEPQEPHGGVRVSGWTPVHTRKQLAIGVNEVTRALERNELLLVLVCKSVKPAIITSHLIQLSLSRTVPACQVPQLSERIAPVIGLKCVLALGFRKNTMDFADEVEAIIPRVPSLNVPWLPDGTQGLTDSLETESLESQDKEVLDTSFDDLTRLKRKLAEGGQAPAATLQPLKIKRLVPNPSKIRKPPKSKNPSK", "length": 272 }, "evidence": [ { "id": "Q32LC1", "url": "https://omabrowser.org/oma/group/Q32LC1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleolar ribonuclease P complex", "id": "GO:0005655", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005655", "evidence": [ { "database": "UniProtKB", "id": "Q32LC1", "url": "https://www.uniprot.org/uniprotkb/Q32LC1" } ], "pmid": "" }, { "name": "multimeric ribonuclease P complex", "id": "GO:0030681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030681", "evidence": [ { "database": "UniProtKB", "id": "Q32LC1", "url": "https://www.uniprot.org/uniprotkb/Q32LC1" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q32LC1", "url": "https://www.uniprot.org/uniprotkb/Q32LC1" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "Q32LC1", "url": "https://www.uniprot.org/uniprotkb/Q32LC1" } ], "pmid": "" }, { "name": "ribonuclease MRP complex", "id": "GO:0000172", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000172", "evidence": [ { "database": "UniProtKB", "id": "Q32LC1", "url": "https://www.uniprot.org/uniprotkb/Q32LC1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "Q32LC1", "url": "https://www.uniprot.org/uniprotkb/Q32LC1" } ], "pmid": "" }, { "name": "tRNA 5'-leader removal", "id": "GO:0001682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001682", "evidence": [ { "database": "UniProtKB", "id": "Q32LC1", "url": "https://www.uniprot.org/uniprotkb/Q32LC1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ribonuclease P activity", "id": "GO:0004526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004526", "evidence": [ { "database": "UniProtKB", "id": "Q32LC1", "url": "https://www.uniprot.org/uniprotkb/Q32LC1" } ], "pmid": "" }, { "name": "ribonuclease P RNA binding", "id": "GO:0033204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033204", "evidence": [ { "database": "UniProtKB", "id": "Q32LC1", "url": "https://www.uniprot.org/uniprotkb/Q32LC1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 185, "end_pos": 187, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LC1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 282, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LC1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LC1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 12, 226, 235 ], "sequon_annotation_sites": [ { "start_pos": 185, "end_pos": 187 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q32LD4-1", "uniprot_ac": "Q32LD4", "uniprot_id": "TFB2M_BOVIN", "mass": { "chemical_mass": 44952.0, "monoisotopic_mass": 44952.0 }, "refseq": { "ac": "NP_001033216", "name": "dimethyladenosine transferase 2, mitochondrial", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033216" }, "gene_names": [ { "name": "TFB2M", "type": "recommended", "evidence": [ { "id": "Q32LD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD4" } ] }, { "name": "TFB2M", "type": "synonym", "evidence": [ { "id": "NP_001033216", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033216" } ] } ], "protein_names": [ { "name": "Dimethyladenosine transferase 2, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q32LD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD4/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.-", "type": "synonym", "evidence": [ { "id": "Q32LD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD4/entry#names_and_taxonomy" } ] }, { "name": "Mitochondrial 12S rRNA dimethylase 2", "type": "synonym", "evidence": [ { "id": "Q32LD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD4/entry#names_and_taxonomy" } ] }, { "name": "Mitochondrial transcription factor B2", "type": "synonym", "evidence": [ { "id": "Q32LD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD4/entry#names_and_taxonomy" } ] }, { "name": "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2", "type": "synonym", "evidence": [ { "id": "NP_001033216", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033216" }, { "id": "Q32LD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD4/entry#names_and_taxonomy" } ] }, { "name": "dimethyladenosine transferase 2, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001033216", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033216" } ] }, { "name": "mitochondrial 12S rRNA dimethylase 2", "type": "synonym", "evidence": [ { "id": "NP_001033216", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033216" } ] }, { "name": "mitochondrial transcription factor B2", "type": "synonym", "evidence": [ { "id": "NP_001033216", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033216" } ] }, { "name": "mtTFB2", "type": "synonym", "evidence": [ { "id": "NP_001033216", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033216" }, { "id": "Q32LD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Stimulates transcription independently of the methyltransferase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q32LD4", "url": "https://www.uniprot.org/uniprotkb/Q32LD4#function" }, { "database": "UniProtKB", "id": "Q9H5Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H5Q4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LD4", "url": "https://www.uniprot.org/uniprotkb/Q32LD4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TFB2M", "url": "https://www.uniprot.org/uniprotkb/Q32LD4", "locus": { "chromosome": "16", "start_pos": 30820744, "end_pos": 30802365, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000072", "url": "https://www.ensembl.org/id/ENSBTAG00000000072" } ] } } ], "crossref": [ { "id": "Q32LD4", "url": "https://alphafold.ebi.ac.uk/entry/Q32LD4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000072", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000072", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "516874", "url": "https://www.ncbi.nlm.nih.gov/gene/516874", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001737", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001737", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516874", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516874", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IFEVPWT", "url": "https://omabrowser.org/oma/group/IFEVPWT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32LD4", "url": "https://www.orthodb.org/?gene=Q32LD4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11727", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11727", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11727:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11727:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00398", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00398", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-163282", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163282", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001033216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033216", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "58728", "url": "https://www.rhea-db.org/rhea/58728", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32LD4", "url": "https://www.uniprot.org/uniprotkb/Q32LD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LD4-1", "url": "https://www.uniprot.org/uniprotkb/Q32LD4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWVPGAGIPSRLTLSAFTRAARFCVLNSGVARWKDVPAENCRGLYDFHTQLKPDVEFGKLSSRLYKSRSETKRYVTSPRVAETVVRVLRGKRKAGQLILECNPGPGVLTRALLESGARVIALESDKNFIPELKSLGNSVNGRLEVIYCDFFKLDPRNHGMVTPPVMTSDMLFQYLGVKAHPWKKGFPLKVVGILPAKTERNTLWKILHDLYSCSSVYKYGRAELNLFISEKECRKLTANPQTPALYQSLSVLGQTACGIKVLCTEPSSLFDTYAIKGELEKQRHRESLEQNLCFVQLTPHRNLFTGTLTPFNYDVFFHMLRQCFMKRNAKLIDHLPSLSPIDAVHILKQIKKKKDVRVVDMYPKDFLRLFETIECSKDDTCKWLYDEFMEDALS", "length": 394, "header": "sp|Q32LD4-1|TFB2M_BOVIN Isoform 1 of Dimethyladenosine transferase 2, mitochondrial OS=Bos taurus OX=9913 GN=TFB2M PE=2 SV=1 CANONICAL=Q32LD4-1" }, "isoforms": [ { "isoform_ac": "Q32LD4-1", "url": "https://www.uniprot.org/uniprotkb/Q32LD4/entry#Q32LD4-1", "sequence": { "sequence": "MWVPGAGIPSRLTLSAFTRAARFCVLNSGVARWKDVPAENCRGLYDFHTQLKPDVEFGKLSSRLYKSRSETKRYVTSPRVAETVVRVLRGKRKAGQLILECNPGPGVLTRALLESGARVIALESDKNFIPELKSLGNSVNGRLEVIYCDFFKLDPRNHGMVTPPVMTSDMLFQYLGVKAHPWKKGFPLKVVGILPAKTERNTLWKILHDLYSCSSVYKYGRAELNLFISEKECRKLTANPQTPALYQSLSVLGQTACGIKVLCTEPSSLFDTYAIKGELEKQRHRESLEQNLCFVQLTPHRNLFTGTLTPFNYDVFFHMLRQCFMKRNAKLIDHLPSLSPIDAVHILKQIKKKKDVRVVDMYPKDFLRLFETIECSKDDTCKWLYDEFMEDALS", "length": 394, "header": "sp|Q32LD4-1|TFB2M_BOVIN Isoform 1 of Dimethyladenosine transferase 2, mitochondrial OS=Bos taurus OX=9913 GN=TFB2M PE=2 SV=1 CANONICAL=Q32LD4-1" }, "locus": { "chromosome": "16", "start_pos": 30820194, "end_pos": 30802523, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000080.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000080.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000080.4", "url": "https://www.ensembl.org/id/ENSBTAP00000000080.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:516874", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516874", "resource": "KEGG Pathway" }, { "id": "R-BTA-163282", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163282", "resource": "Reactome", "description": "Mitochondrial transcription initiation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LEF8-1", "protein_name": "rRNA adenine N(6)-methyltransferase", "gene_name": "Tfb2m", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MWGPAMGLPPRLALSVFAGPARSCVLGSRTAARKDWQAKSRRGFSDFYMQPLFDPELEESPFFAPKGRSEPTCYVACKKLAKNLVRNLLGYHNPSRQLLLECNPGPGILTEALLRAGARVIAFESEKTFIPHLKSLRMHLDGLLQVVHSDFFKIDPRHQEVVKPEYNSRIIFKDLGINPVPWSAGVPIKVFGILPTKLERRILWKTLFDLYSCESIYRYGRIELNLFVTEKEFQRLIATPKRPDLYQVLSVLWQVACDIKFIHMEPWSSFSMHNENGSSENSKLGESLKSMKQNLYFIQLTPRRTLFTEHLSPLNYDIFFHMVKHCFGKRSSPIIQHLRSLSTVEPIEILRKVRIKPGETILRMYPHDFKRLFEMIERSEDCVFKWVYDESLEDIVL", "length": 397 }, "evidence": [ { "id": "Q32LD4", "url": "https://omabrowser.org/oma/group/Q32LD4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1NSS3-1", "protein_name": "rRNA adenine N(6)-methyltransferase", "gene_name": "TFB2M", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRAGRALPGAAGCGRLLAAGLRPLLGGPGPCWATVRRAAGRWPSPGLRVPQAAEAEQLVLRAGGPWGRFIACPQLARTVQRCLQAGSGPQPVVLECAPGPGVLTRTLLNAGVRVVALESHPAFLSKLQSLENSLDGQLKVIYGDFFRLDPLVTGAVKPPAVCSDKLFEAMGIAAVPWRADVPVKIFGIFPQRKERNTLWRLLFILYECSSIYRYGRVELNIFISEKEYKVLTAKPGELRIYQALSVLWQAGCDIQLLHMEPWSSFLTNMKNGRLAIPKSTRLPNDHLCLVRLTPQQNLFTGGLKPANSATFIFMVKQCLTKPRSKLIDRLNSWSLDNADKLLKALEIPEYVETGNVYPEDYKRLFCALQNSSVFTESWFHDEVLESIRNINL", "length": 392 }, "evidence": [ { "id": "Q32LD4", "url": "https://omabrowser.org/oma/group/Q32LD4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3L5G3-1", "protein_name": "rRNA adenine N(6)-methyltransferase", "gene_name": "TFB2M", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MWVPWAGLPPRLTLSALTVPGRFCTLRSGAARRKDVPAGHRRALSDFQPKLVPCVGFGKSRVYKHNSEPKRYITNPRVAENLVRILRRKRKSGQLFLECNPGPGFLTRALLESGARVIACESDKAFIPQLEDLGQKLGGKLKVVYCDFFKLDPRGHGALTPPIMTAETLFRNLGIGPNPWSKGAAFKVVGVLPTRNERNTLWKLLHDLYSCTSIYEYGRVEVNMFVTEKECRKIMANPQNPNLYQALSVLCQLACGIKVLHTEPCSSFRTFIQNGQLEKKQHRESEQNLCFIQLSPHRNLFARTLTPFNYDVFFHMVRQCFMKRNAMLVDHLRSLSPVDALHIMNQMRKKHSMKIVDMYPEDFQRLFEIIECSKDGACRWLYDDFMEDTLT", "length": 391 }, "evidence": [ { "id": "Q32LD4", "url": "https://omabrowser.org/oma/group/Q32LD4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3TL26-1", "protein_name": "Dimethyladenosine transferase 2, mitochondrial", "gene_name": "Tfb2m", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRGPAMRLPPRIALSALARGPSCILGSGAATRKDWQTRNRRGFSDFNIEPLPDSDLEESSPWTSRNRSEPTRHIACKKAARNLVRDLLEHQNPSRQIILECNPGPGILTGALLKAGARVVAFESEKTFIPHLEPLQRNMDGELQVVHCDFFKMDPRYQEVVRPDVSSQAIFQNLGIKAVPWSAGVPIKVFGILPYKHERRILWKILFDLYSCESIYRYGRVELNMFVSEKEFRKLIATPKRPDLYQVMAVLWQVACDVKFLHMEPWSSFSVHTENGHLEKSKHGESVNLLKQNLYLVRMTPRRTLFTENLSPLNYDIFFHLVKHCFGKRNAPIIRHLRSLSTVDPINILRQIRKNPGDTAARMYPHDFKKLFETIEQSEDSVFKWIYDYCPEDMEF", "length": 396 }, "evidence": [ { "id": "Q32LD4", "url": "https://omabrowser.org/oma/group/Q32LD4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5U2T7-1", "protein_name": "Dimethyladenosine transferase 2, mitochondrial", "gene_name": "Tfb2m", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRGLAMRLPPRLALSVLAGRGPSCILGSGAATRKDWQERNRRSFSDLYTQPLPDCDFEESSSWTHKSRSEPTRHIACKKSARNLVRDLLEHQNPSHQLILECNPGPGILTGALLKAGARVVAFESEKMFIPHLESLRKNADGELQVVHCDFFKIDPRYQELVRPDVNSHTIFQNLGIKAVPWSAGVPIKVFGILPNKHERRLLWKILFDLYSCESIYRYGRVELNMFISEKEFRKLIATPKRPDLYQVLGVLWQVACEIKFLHMEPWSSFSVHAENGHLEKSKHSESLNLLKQNLYLVRMTPRRTLFTENLSPLNYDMFFHLVKHCFGKRNAPIIHHLRSLSTVDPINILRQIRKRPGDTAAKMYPHDFKRLFETIERSEDSVFKWIYDYCSDDSEL", "length": 397 }, "evidence": [ { "id": "Q32LD4", "url": "https://omabrowser.org/oma/group/Q32LD4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9H5Q4-1", "protein_name": "Dimethyladenosine transferase 2, mitochondrial", "gene_name": "TFB2M", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLAQIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKNLGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQKLMADPGNPDLYHVLSVIWQLACEIKVLHMEPWSSFDIYTRKGPLENPKRRELLDQLQQKLYLIQMIPRQNLFTKNLTPMNYNIFFHLLKHCFGRRSATVIDHLRSLTPLDARDILMQIGKQEDEKVVNMHPQDFKTLFETIERSKDCAYKWLYDETLEDR", "length": 396 }, "evidence": [ { "id": "Q32LD4", "url": "https://omabrowser.org/oma/group/Q32LD4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "rRNA methylation", "id": "GO:0031167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031167", "evidence": [ { "database": "UniProtKB", "id": "Q32LD4", "url": "https://www.uniprot.org/uniprotkb/Q32LD4" } ], "pmid": "" }, { "name": "transcription initiation at mitochondrial promoter", "id": "GO:0006391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006391", "evidence": [ { "database": "UniProtKB", "id": "Q32LD4", "url": "https://www.uniprot.org/uniprotkb/Q32LD4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q32LD4", "url": "https://www.uniprot.org/uniprotkb/Q32LD4" } ], "pmid": "" }, { "name": "rRNA (adenine-N6,N6-)-dimethyltransferase activity", "id": "GO:0000179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000179", "evidence": [ { "database": "UniProtKB", "id": "Q32LD4", "url": "https://www.uniprot.org/uniprotkb/Q32LD4" } ], "pmid": "" }, { "name": "mitochondrial transcription factor activity", "id": "GO:0034246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034246", "evidence": [ { "database": "UniProtKB", "id": "Q32LD4", "url": "https://www.uniprot.org/uniprotkb/Q32LD4" } ], "pmid": "" }, { "name": "rRNA (adenine-N6-)-methyltransferase activity", "id": "GO:0008988", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008988", "evidence": [ { "database": "UniProtKB", "id": "Q32LD4", "url": "https://www.uniprot.org/uniprotkb/Q32LD4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q32LD4", "url": "https://www.uniprot.org/uniprotkb/Q32LD4" } ], "pmid": "" }, { "name": "mitochondrial nucleoid", "id": "GO:0042645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042645", "evidence": [ { "database": "UniProtKB", "id": "Q32LD4", "url": "https://www.uniprot.org/uniprotkb/Q32LD4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "58728", "name": "", "equation": "adenosine in rRNA + S-adenosyl-L-methionine = N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q32LD4-1" ], "evidence": [ { "id": "58728", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/58728" } ] }, { "id": "R-BTA-163296", "name": "Association of TFAM:mt promoter complex with POLRMT:TFB2M", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BCZ0-1", "Q32LD4-1" ], "evidence": [ { "id": "R-BTA-163296", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163296" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "E1BCZ0", "gene_name": "POLRMT", "activity": [ { "ec_number": "2.7.7.6", "activity": "RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate.", "evidence": [ { "id": "E1BCZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCZ0" } ] }, { "ec_number": "2.7.7.6", "activity": "", "evidence": [ { "id": "E1BCZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCZ0" } ] } ] }, { "uniprot_ac": "Q32LD4", "gene_name": "TFB2M", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q32LD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LD4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 394, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LD4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LD4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LD7-1", "uniprot_ac": "Q32LD7", "uniprot_id": "TASL_BOVIN", "mass": { "chemical_mass": 33758.0, "monoisotopic_mass": 33758.0 }, "refseq": { "ac": "NP_001033626", "name": "TLR adapter interacting with SLC15A4 on the lysosome", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033626" }, "gene_names": [ { "name": "TASL", "type": "recommended", "evidence": [ { "id": "Q32LD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD7" } ] }, { "name": "C9HXorf21", "type": "synonym", "evidence": [ { "id": "NP_001033626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033626" } ] }, { "name": "CXHXorf21", "type": "synonym", "evidence": [ { "id": "NP_001033626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033626" } ] }, { "name": "CXorf21", "type": "synonym", "evidence": [ { "id": "NP_001033626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033626" } ] }, { "name": "TASL", "type": "synonym", "evidence": [ { "id": "NP_001033626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033626" } ] } ], "protein_names": [ { "name": "TLR adapter interacting with SLC15A4 on the lysosome", "type": "recommended", "evidence": [ { "id": "Q32LD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD7/entry#names_and_taxonomy" } ] }, { "name": "TLR adapter interacting with SLC15A4 on the lysosome", "type": "synonym", "evidence": [ { "id": "NP_001033626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033626" } ] }, { "name": "chromosome X CXorf21 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033626" } ] }, { "name": "uncharacterized protein CXorf21 homolog", "type": "synonym", "evidence": [ { "id": "NP_001033626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033626" } ] } ], "function": [ { "annotation": "Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons. Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes.", "evidence": [ { "database": "UniProtKB", "id": "Q32LD7", "url": "https://www.uniprot.org/uniprotkb/Q32LD7#function" }, { "database": "UniProtKB", "id": "Q9HAI6", "url": "https://www.uniprot.org/uniprotkb/Q9HAI6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LD7", "url": "https://www.uniprot.org/uniprotkb/Q32LD7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TASL", "url": "https://www.uniprot.org/uniprotkb/Q32LD7", "locus": { "chromosome": "X", "start_pos": 113023102, "end_pos": 113007421, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000058370", "url": "https://www.ensembl.org/id/ENSBTAG00000058370" } ] } } ], "crossref": [ { "id": "Q32LD7", "url": "https://alphafold.ebi.ac.uk/entry/Q32LD7", "database": "AlphaFoldDB", "categories": [] }, { "id": "513911", "url": "https://www.ncbi.nlm.nih.gov/gene/513911", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513911", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513911", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32LD7", "url": "https://www.orthodb.org/?gene=Q32LD7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14889", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14889", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14889:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14889:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15133", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15133", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033626", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LD7", "url": "https://www.uniprot.org/uniprotkb/Q32LD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LD7-1", "url": "https://www.uniprot.org/uniprotkb/Q32LD7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSEGYLSGLAYRNDIQWSYPSSNEQVAEEKEEEMEATAAASLSYSSVDETQVQNLYVSCKSSGKVISSVYSRESQHSRNPRITVLQTNPNPVYESPNLAAVELYRDTSRETYLVPPSCKSICKNYNDLQIAGGQVMAINSATTDFPSEGSFQYGPLLKSSEIPLSMEDSMFTQPSDLPPTPIQRYSSYWRITSIKEKNSLQMQKPISNAVLNEYLEQKLVELYKQYFMDTGFHDSSPTQILASELIMTNVDQISIQVSIEKNLEISKARDIVINRLLQYGSTEISTQSLHISQYSNVNP", "length": 300, "header": "sp|Q32LD7-1|TASL_BOVIN Isoform 1 of TLR adapter interacting with SLC15A4 on the lysosome OS=Bos taurus OX=9913 GN=TASL PE=2 SV=1 CANONICAL=Q32LD7-1" }, "isoforms": [ { "isoform_ac": "Q32LD7-1", "url": "https://www.uniprot.org/uniprotkb/Q32LD7/entry#Q32LD7-1", "sequence": { "sequence": "MLSEGYLSGLAYRNDIQWSYPSSNEQVAEEKEEEMEATAAASLSYSSVDETQVQNLYVSCKSSGKVISSVYSRESQHSRNPRITVLQTNPNPVYESPNLAAVELYRDTSRETYLVPPSCKSICKNYNDLQIAGGQVMAINSATTDFPSEGSFQYGPLLKSSEIPLSMEDSMFTQPSDLPPTPIQRYSSYWRITSIKEKNSLQMQKPISNAVLNEYLEQKLVELYKQYFMDTGFHDSSPTQILASELIMTNVDQISIQVSIEKNLEISKARDIVINRLLQYGSTEISTQSLHISQYSNVNP", "length": 300, "header": "sp|Q32LD7-1|TASL_BOVIN Isoform 1 of TLR adapter interacting with SLC15A4 on the lysosome OS=Bos taurus OX=9913 GN=TASL PE=2 SV=1 CANONICAL=Q32LD7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 293, "end_pos": 293, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LD7", "url": "https://www.uniprot.org/uniprotkb/Q32LD7" } ], "site_lbl": "Ser293" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513911", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513911", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32LD7", "url": "https://www.uniprot.org/uniprotkb/Q32LD7" } ], "pmid": "" }, { "name": "endolysosome membrane", "id": "GO:0036020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036020", "evidence": [ { "database": "UniProtKB", "id": "Q32LD7", "url": "https://www.uniprot.org/uniprotkb/Q32LD7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "regulation of toll-like receptor signaling pathway", "id": "GO:0034121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034121", "evidence": [ { "database": "UniProtKB", "id": "Q32LD7", "url": "https://www.uniprot.org/uniprotkb/Q32LD7" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "Q32LD7", "url": "https://www.uniprot.org/uniprotkb/Q32LD7" } ], "pmid": "" }, { "name": "positive regulation of toll-like receptor 7 signaling pathway", "id": "GO:0034157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034157", "evidence": [ { "database": "UniProtKB", "id": "Q32LD7", "url": "https://www.uniprot.org/uniprotkb/Q32LD7" } ], "pmid": "" }, { "name": "positive regulation of innate immune response", "id": "GO:0045089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045089", "evidence": [ { "database": "UniProtKB", "id": "Q32LD7", "url": "https://www.uniprot.org/uniprotkb/Q32LD7" } ], "pmid": "" }, { "name": "regulation of lysosomal lumen pH", "id": "GO:0035751", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035751", "evidence": [ { "database": "UniProtKB", "id": "Q32LD7", "url": "https://www.uniprot.org/uniprotkb/Q32LD7" } ], "pmid": "" }, { "name": "positive regulation of toll-like receptor 8 signaling pathway", "id": "GO:0034161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034161", "evidence": [ { "database": "UniProtKB", "id": "Q32LD7", "url": "https://www.uniprot.org/uniprotkb/Q32LD7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LD7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 300, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LD7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LD7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32LD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LD7" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "pLxIS motif", "eco_id": "ECO_0000250", "start_pos": 289, "end_pos": 293, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 293 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LE3-1", "uniprot_ac": "Q32LE3", "uniprot_id": "CETN1_BOVIN", "mass": { "chemical_mass": 19697.0, "monoisotopic_mass": 19697.0 }, "refseq": { "ac": "NP_001072974", "name": "centrin-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001072974" }, "gene_names": [ { "name": "CETN1", "type": "recommended", "evidence": [ { "id": "Q32LE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LE3" } ] }, { "name": "CETN1", "type": "synonym", "evidence": [ { "id": "NP_001072974", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001072974" } ] } ], "protein_names": [ { "name": "Centrin-1", "type": "recommended", "evidence": [ { "id": "Q32LE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LE3/entry#names_and_taxonomy" } ] }, { "name": "centrin, EF-hand protein, 1", "type": "synonym", "evidence": [ { "id": "NP_001072974", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001072974" } ] }, { "name": "centrin-1", "type": "synonym", "evidence": [ { "id": "NP_001072974", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001072974" } ] } ], "function": [ { "annotation": "Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32LE3", "url": "https://www.uniprot.org/uniprotkb/Q32LE3#function" }, { "database": "UniProtKB", "id": "Q12798", "url": "https://www.uniprot.org/uniprotkb/Q12798#function" }, { "database": "UniProtKB", "id": "P41209", "url": "https://www.uniprot.org/uniprotkb/P41209#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LE3", "url": "https://www.uniprot.org/uniprotkb/Q32LE3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CETN1", "url": "https://www.uniprot.org/uniprotkb/Q32LE3", "locus": { "chromosome": "24", "start_pos": 35489569, "end_pos": 35488684, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012320", "url": "https://www.ensembl.org/id/ENSBTAG00000012320" } ] } } ], "crossref": [ { "id": "Q32LE3", "url": "https://alphafold.ebi.ac.uk/entry/Q32LE3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012320", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012320", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512850", "url": "https://www.ncbi.nlm.nih.gov/gene/512850", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000629", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000629", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050230", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050230", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512850", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512850", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CIEAREF", "url": "https://omabrowser.org/oma/group/CIEAREF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32LE3", "url": "https://www.orthodb.org/?gene=Q32LE3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23048", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23048", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23048:SF59", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23048:SF59", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9646399", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9646399", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001072974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001072974", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LE3", "url": "https://www.uniprot.org/uniprotkb/Q32LE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LE3-1", "url": "https://www.uniprot.org/uniprotkb/Q32LE3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASSYRKPTVASTSQKRKVGPKPELTEEQKQEVREAFDLFDADGSGTIDVKELKVAMRALGFEPRKEEMKRMIADVDKEGTGKISFNDFLAVMTQKMAEKDTKEEILKAFRLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVNEDEFLRIMKKTNLY", "length": 172, "header": "sp|Q32LE3-1|CETN1_BOVIN Isoform 1 of Centrin-1 OS=Bos taurus OX=9913 GN=CETN1 PE=2 SV=1 CANONICAL=Q32LE3-1" }, "isoforms": [ { "isoform_ac": "Q32LE3-1", "url": "https://www.uniprot.org/uniprotkb/Q32LE3/entry#Q32LE3-1", "sequence": { "sequence": "MASSYRKPTVASTSQKRKVGPKPELTEEQKQEVREAFDLFDADGSGTIDVKELKVAMRALGFEPRKEEMKRMIADVDKEGTGKISFNDFLAVMTQKMAEKDTKEEILKAFRLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVNEDEFLRIMKKTNLY", "length": 172, "header": "sp|Q32LE3-1|CETN1_BOVIN Isoform 1 of Centrin-1 OS=Bos taurus OX=9913 GN=CETN1 PE=2 SV=1 CANONICAL=Q32LE3-1" }, "locus": { "chromosome": "24", "start_pos": 35489409, "end_pos": 35488894, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016356.3", "url": "https://www.ensembl.org/id/ENSBTAT00000016356.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052557.1", "url": "https://www.ensembl.org/id/ENSBTAP00000052557.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512850", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512850", "resource": "KEGG Pathway" }, { "id": "R-BTA-9646399", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9646399", "resource": "Reactome", "description": "Aggrephagy" } ], "orthologs": [ { "uniprot_canonical_ac": "P41209-1", "protein_name": "Centrin-1", "gene_name": "Cetn1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASTFRKSNVASTSYKRKVGPKPELTEDQKQEVREAFDLFDSDGSGTIDVKELKVAMRALGFEPRKEEMKKMISEVDKEATGKISFNDFLAVMTQKMAEKDTKEEILKAFRLFDDDETGKISFKNLKRVANELGESLTDEELQEMIDEADRDGDGEVNEEEFLKIMKKTNLY", "length": 172 }, "evidence": [ { "id": "Q32LE3", "url": "https://omabrowser.org/oma/group/Q32LE3/", "database": "OMA" } ], 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"id": "Q32LE4", "url": "https://alphafold.ebi.ac.uk/entry/Q32LE4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010597", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010597", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06661", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06661", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533374", "url": "https://www.ncbi.nlm.nih.gov/gene/533374", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017939", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036568", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036568", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533374", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533374", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "APHDYVM", "url": "https://omabrowser.org/oma/group/APHDYVM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32LE4", "url": "https://www.orthodb.org/?gene=Q32LE4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12935", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12935", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12935:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12935:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13772", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13772", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-174403", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174403", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001032699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032699", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "20505", "url": "https://www.rhea-db.org/rhea/20505", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32LE4", "url": "https://www.uniprot.org/uniprotkb/Q32LE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LE4-1", "url": "https://www.uniprot.org/uniprotkb/Q32LE4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANFGCEDLRSQDGESFLYFAYGSNLLTERIHLRNPSAVFYSVARLQDFKLDFGNPQGKTSETWHGGIATIFESPGDEVWGVVWKMNKSNLSSLDKQEGVKSGMYVPIEVTVSTQEGKEITCRSYQMTNYESVPPSPQYKKVICMGAKENGLPLEYQKKLNSIEPNDYKGKVSEEIEDIIKKGEAKTH", "length": 188, "header": "sp|Q32LE4-1|GGCT_BOVIN Isoform 1 of Gamma-glutamylcyclotransferase OS=Bos taurus OX=9913 GN=GGCT PE=2 SV=1 CANONICAL=Q32LE4-1" }, "isoforms": [ { "isoform_ac": "Q32LE4-1", "url": "https://www.uniprot.org/uniprotkb/Q32LE4/entry#Q32LE4-1", "sequence": { "sequence": "MANFGCEDLRSQDGESFLYFAYGSNLLTERIHLRNPSAVFYSVARLQDFKLDFGNPQGKTSETWHGGIATIFESPGDEVWGVVWKMNKSNLSSLDKQEGVKSGMYVPIEVTVSTQEGKEITCRSYQMTNYESVPPSPQYKKVICMGAKENGLPLEYQKKLNSIEPNDYKGKVSEEIEDIIKKGEAKTH", "length": 188, "header": "sp|Q32LE4-1|GGCT_BOVIN Isoform 1 of Gamma-glutamylcyclotransferase OS=Bos taurus OX=9913 GN=GGCT PE=2 SV=1 CANONICAL=Q32LE4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 173, "end_pos": 173, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LE4", "url": "https://www.uniprot.org/uniprotkb/Q32LE4" } ], "site_lbl": "Ser173" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:533374", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533374", "resource": "KEGG Pathway" }, { "id": "R-BTA-174403", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174403", "resource": "Reactome", "description": "Glutathione synthesis and recycling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1T8A6-1", "protein_name": "gamma-glutamylcyclotransferase", "gene_name": "GGCT", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MANSGGEDRGGQEEESFLYFAYGSNLLMERIHLRNPSAEFYCVARLQDFKLDFGNSQGKTSETWHGGIATIFESPGDEVWGVVWKMNKSNLSSLDESFARVQKRMVCHWSIKRS", "length": 114 }, "evidence": [ { "id": "Q32LE4", "url": "https://omabrowser.org/oma/group/Q32LE4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZPV8-1", "protein_name": "Gamma-glutamylcyclotransferase", "gene_name": "Ggct", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSCWRGQVDMASSDCEDHAGQEGETFLYFAYGSNLLTERIHLRNPSAVFCCVARLQDFKLDFGNFQGKMSERWHGGIATIFQSPGDEVWGVVWKMNKSNLSSLDEQEGVKSGVYVVIEIKVTTQQGKDITCRSYLMTNYERAPPSPQYKKVICMGAKENGLPLEYQEKLNVIEPNDYKGKISDEMEDIIKKGEAKLL", "length": 198 }, "evidence": [ { "id": "Q32LE4", "url": "https://omabrowser.org/oma/group/Q32LE4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HJM5-1", "protein_name": "Gamma-glutamylcyclotransferase", "gene_name": "Ggct", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASSGCEDHAGQEGETFLYFAYGSNLLTERIHLRNPSAVFCCVARLQDFKLDFGNFQGKTSERWHGGIATIFQSPGDEVWGVVWKMNKSNLSSLDEQEGVKSGVYVVIEIKVSTQEGKEITCRSYLMTNYESAPPSPQYKKVICMGAKENGLPLEYQEKLKAIEPNDYKGKISDEMEEIIKKGESKLYRT", "length": 190 }, "evidence": [ { "id": "Q32LE4", "url": "https://omabrowser.org/oma/group/Q32LE4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O75223-1", "protein_name": "Gamma-glutamylcyclotransferase", "gene_name": "GGCT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MANSGCKDVTGPDEESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNSQGKTSQTWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEQEGVKSGMYVVIEVKVATQEGKEITCRSYLMTNYESAPPSPQYKKIICMGAKENGLPLEYQEKLKAIEPNDYTGKVSEEIEDIIKKGETQTL", "length": 188 }, "evidence": [ { "id": "Q32LE4", "url": "https://omabrowser.org/oma/group/Q32LE4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D7X8-1", "protein_name": "Gamma-glutamylcyclotransferase", "gene_name": "Ggct", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASSDCEGHAGQEGETFLYFAYGSNLLTERIHLRNPSAVFCCVARLQDFKLDFGNFQGKMSERWHGGIATIFQSPGDEVWGVVWRMNKSNISSLDEQEGVKSGVYVVIEIKVSTREGKEITCRSYLMTNYESAPPSPQYKKVICMGAKENGLPQEYQEKLKAIEPNEYKGKISDEMEDIIKKGESKLS", "length": 188 }, "evidence": [ { "id": "Q32LE4", "url": "https://omabrowser.org/oma/group/Q32LE4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "gamma-glutamylcyclotransferase activity", "id": "GO:0003839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003839", "evidence": [ { "database": "UniProtKB", "id": "Q32LE4", "url": "https://www.uniprot.org/uniprotkb/Q32LE4" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q32LE4", "url": "https://www.uniprot.org/uniprotkb/Q32LE4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q32LE4", "url": "https://www.uniprot.org/uniprotkb/Q32LE4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "release of cytochrome c from mitochondria", "id": "GO:0001836", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001836", "evidence": [ { "database": "UniProtKB", "id": "Q32LE4", "url": "https://www.uniprot.org/uniprotkb/Q32LE4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20505", "name": "", "equation": "an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q32LE4-1", "A0AAF6YUX3-1" ], "evidence": [ { "id": "20505", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20505" } ] }, { "id": "R-BTA-1247922", "name": "GGCT transforms gGluCys to OPRO", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q32LE4-1" ], "evidence": [ { "id": "R-BTA-1247922", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1247922" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6YUX3", "gene_name": "GGCT", "activity": [ { "ec_number": "4.3.2.9", "activity": "an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid.", "evidence": [ { "id": "A0AAF6YUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUX3" } ] }, { "ec_number": "4.3.2.9", "activity": "", "evidence": [ { "id": "A0AAF6YUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUX3" } ] } ] }, { "uniprot_ac": "Q32LE4", "gene_name": "GGCT", "activity": [ { "ec_number": "4.3.2.9", "activity": "an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid.", "evidence": [ { "id": "Q32LE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LE4" } ] }, { "ec_number": "4.3.2.9", "activity": "", "evidence": [ { "id": "Q32LE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LE4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LE4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 188, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LE4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LE4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "4.3.2.9", "ec_name": "an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid.", "evidence": [ { "id": "4.3.2.9", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.9" }, { "id": "4.3.2.9", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=4.3.2.9" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 173 ], "sequon_annotation_sites": [ { "start_pos": 87, "end_pos": 89 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LE7-1", "uniprot_ac": "Q32LE7", "uniprot_id": "PDZ11_BOVIN", "mass": { "chemical_mass": 16155.0, "monoisotopic_mass": 16155.0 }, "refseq": { "ac": "NP_001032692", "name": "PDZ domain-containing protein 11", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032692" }, "gene_names": [ { "name": "PDZD11", "type": "recommended", "evidence": [ { "id": "Q32LE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LE7" } ] }, { "name": "PDZD11", "type": "synonym", "evidence": [ { "id": "NP_001032692", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032692" } ] } ], "protein_names": [ { "name": "PDZ domain-containing protein 11", "type": "recommended", "evidence": [ { "id": "Q32LE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LE7/entry#names_and_taxonomy" } ] }, { "name": "PDZ domain-containing protein 11", "type": "synonym", "evidence": [ { "id": "NP_001032692", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032692" } ] } ], "function": [ { "annotation": "Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10-binding protein TSPAN33.", "evidence": [ { "database": "UniProtKB", "id": "Q32LE7", "url": "https://www.uniprot.org/uniprotkb/Q32LE7#function" }, { "database": "UniProtKB", "id": "Q5EBL8", "url": "https://www.uniprot.org/uniprotkb/Q5EBL8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LE7", "url": "https://www.uniprot.org/uniprotkb/Q32LE7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PDZD11", "url": "https://www.uniprot.org/uniprotkb/Q32LE7", "locus": { "chromosome": "X", "start_pos": 80156420, "end_pos": 80153514, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012860", "url": "https://www.ensembl.org/id/ENSBTAG00000012860" } ] } } ], "crossref": [ { "id": "Q32LE7", "url": "https://alphafold.ebi.ac.uk/entry/Q32LE7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012860", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012860", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06752", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06752", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515371", "url": "https://www.ncbi.nlm.nih.gov/gene/515371", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515371", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515371", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RGGREHN", "url": "https://omabrowser.org/oma/group/RGGREHN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32LE7", "url": "https://www.orthodb.org/?gene=Q32LE7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14063", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14063", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-196780", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196780", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-199220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-199220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-425397", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-425397", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001032692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032692", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LE7", "url": "https://www.uniprot.org/uniprotkb/Q32LE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LE7-1", "url": "https://www.uniprot.org/uniprotkb/Q32LE7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSRIPYDDYPVVFLPAYENPPAWIPPHERVYHPDYNNELTQFLPRIVTLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREISMRVRFFPYNYHRQKERTVH", "length": 140, "header": "sp|Q32LE7-1|PDZ11_BOVIN Isoform 1 of PDZ domain-containing protein 11 OS=Bos taurus OX=9913 GN=PDZD11 PE=2 SV=1 CANONICAL=Q32LE7-1" }, "isoforms": [ { "isoform_ac": "Q32LE7-1", "url": "https://www.uniprot.org/uniprotkb/Q32LE7/entry#Q32LE7-1", "sequence": { "sequence": "MDSRIPYDDYPVVFLPAYENPPAWIPPHERVYHPDYNNELTQFLPRIVTLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREISMRVRFFPYNYHRQKERTVH", "length": 140, "header": "sp|Q32LE7-1|PDZ11_BOVIN Isoform 1 of PDZ domain-containing protein 11 OS=Bos taurus OX=9913 GN=PDZD11 PE=2 SV=1 CANONICAL=Q32LE7-1" }, "locus": { "chromosome": "X", "start_pos": 80155887, "end_pos": 80154087, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152941.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152941.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104416.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104416.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515371", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515371", "resource": "KEGG Pathway" }, { "id": "R-BTA-196780", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196780", 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"uniprot_canonical_ac": "Q5EBL8-1", "protein_name": "PDZ domain-containing protein 11", "gene_name": "PDZD11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDSRIPYDDYPVVFLPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREISMRVRFFPYNYHRQKERTVH", "length": 140 }, "evidence": [ { "id": "Q32LE7", "url": "https://omabrowser.org/oma/group/Q32LE7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5ZIK2-1", "protein_name": "PDZ domain-containing protein 11", "gene_name": "PDZD11", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEGRLPYDDFPVVFLPPYESPPAWVPPHERVYHPDYNNELTQFLPRTVVLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLSVNDVDFQDIEHSKAVEILKTAREITMRVRYFPYSKCLLAPNLVT", "length": 140 }, "evidence": [ { "id": "Q32LE7", "url": "https://omabrowser.org/oma/group/Q32LE7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6NXB2-1", "protein_name": "PDZ domain-containing protein 11", "gene_name": "pdzd11", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDQKIPYDDYQLPVVFLPSYENPPAWIPPQERIHHPDYNNELAQFLPRTIVLKKPPGAQLGFNIRGGKASQLGIFISKVVPDSDAHRAGLQEGDQVLSVNEVDFQDIEHSRAVEILKTAREILMKVRYFPYNYQRQKERTVH", "length": 142 }, "evidence": [ { "id": "Q32LE7", "url": "https://omabrowser.org/oma/group/Q32LE7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6QA76-1", "protein_name": "PDZ domain-containing protein 11", "gene_name": "PDZD11", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDSRIPYDDYPVVFLPAYENPPAWIPPHERVYHPDYNNELTQFLPRIVTLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREISMRVRFFPYNYHRQKERTVH", "length": 140 }, "evidence": [ { "id": "Q32LE7", "url": "https://omabrowser.org/oma/group/Q32LE7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": 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"url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24271:SF56", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271:SF56", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035599", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LI2", "url": "https://www.uniprot.org/uniprotkb/Q32LI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LI2-1", "url": "https://www.uniprot.org/uniprotkb/Q32LI2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNLILLWALLNLPVALTFDPNYKDDITPPYLIYLKSDYLPCVGVLIHPLWVITAANCNLPRLQLILGVTKPSNIDEEKYVQVVGYEKMIHHPQFSITSIEHNLMLIKLQTHIELNNYVKIVSLPKEPAAEDDTCIVSTWAYNLCDHYKDPDSLQNVNISVISKVECLKAYKYMHIRDSMMCVGIVPGRRQPCKEVTAAPAVCNGILQGILTFADGCVLRADVGIYTRIINYIPWIENTIQNN", "length": 242, "header": "sp|Q32LI2-1|PRS58_BOVIN Isoform 1 of Probable inactive serine protease 58 OS=Bos taurus OX=9913 GN=PRSS58 PE=2 SV=1 CANONICAL=Q32LI2-1" }, "isoforms": [ { "isoform_ac": "Q32LI2-1", "url": "https://www.uniprot.org/uniprotkb/Q32LI2/entry#Q32LI2-1", "sequence": { "sequence": "MNLILLWALLNLPVALTFDPNYKDDITPPYLIYLKSDYLPCVGVLIHPLWVITAANCNLPRLQLILGVTKPSNIDEEKYVQVVGYEKMIHHPQFSITSIEHNLMLIKLQTHIELNNYVKIVSLPKEPAAEDDTCIVSTWAYNLCDHYKDPDSLQNVNISVISKVECLKAYKYMHIRDSMMCVGIVPGRRQPCKEVTAAPAVCNGILQGILTFADGCVLRADVGIYTRIINYIPWIENTIQNN", "length": 242, "header": "sp|Q32LI2-1|PRS58_BOVIN Isoform 1 of Probable inactive serine protease 58 OS=Bos taurus OX=9913 GN=PRSS58 PE=2 SV=1 CANONICAL=Q32LI2-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 157, "start_aa": "Asn", "end_pos": 157, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn157", "evidence": [ { "id": "Q32LI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LI2#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:506919", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506919", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6IE06-1", "protein_name": "Putative inactive serine protease 58", "gene_name": "Prss58", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKLVFCILSTLLGTFAYNPDHIAGTTPPYLVYLKSDYLPCTGVLIHPLWVVTSAHCNLPDLRVILGITNPADTTEHDVEVSDYEKMFRHPYFSVSSISYDLMLIKLRRGIKHSYYAKAVKLPQHTVPVNAMCSVSTWAYNLCDVTKEPDSLQTVNVSVISKAECHNAYKAFDIRENMICVGIVPGRRLPCKEVTAAPAVCNGVLYGILSYADGCVLRADVGIYASIFHYMPWIENIMKNN", "length": 240 }, "evidence": [ { "id": "Q32LI2", "url": "https://omabrowser.org/oma/group/Q32LI2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BW11-1", "protein_name": "Putative inactive serine protease 58", "gene_name": "Prss58", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKLAFLCILSTLLRTFAYNPDHIAGTTPPYLVYLKSDYLPCTGVLIHPLWVITAAHCNLPNLQVILGITNPADPMERDVEVSDYEKIFHHPNFLVSSISHDLLLIKLKRRIKHSNYAKAVKLPQHIVSVNAMCSVSTWAYNLCDVTKDPDSLQTVNVTVISKAECRNAYKAFDITENMICVGIVPGRRLPCKEVTAAPAVCNGVLYGILSYADGCVLRADVGIYASIFHYLPWIEDTMKNN", "length": 241 }, "evidence": [ { "id": "Q32LI2", "url": "https://omabrowser.org/oma/group/Q32LI2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IYP2-1", "protein_name": "Serine protease 58", "gene_name": "PRSS58", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKFILLWALLNLTVALAFNPDYTVSSTPPYLVYLKSDYLPCAGVLIHPLWVITAAHCNLPKLRVILGVTIPADSNEKHLQVIGYEKMIHHPHFSVTSIDHDIMLIKLKTEAELNDYVKLANLPYQTISENTMCSVSTWSYNVCDIYKEPDSLQTVNISVISKPQCRDAYKTYNITENMLCVGIVPGRRQPCKEVSAAPAICNGMLQGILSFADGCVLRADVGIYAKIFYYIPWIENVIQNN", "length": 241 }, "evidence": [ { "id": "Q32LI2", "url": "https://omabrowser.org/oma/group/Q32LI2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "Q32LI2", "url": "https://www.uniprot.org/uniprotkb/Q32LI2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q32LI2", "url": "https://www.uniprot.org/uniprotkb/Q32LI2" } ], "pmid": "" }, { "name": "secretory granule", "id": "GO:0030141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030141", "evidence": [ { "database": "UniProtKB", "id": "Q32LI2", "url": "https://www.uniprot.org/uniprotkb/Q32LI2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "Q32LI2", "url": "https://www.uniprot.org/uniprotkb/Q32LI2" } ], "pmid": "" }, { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "Q32LI2", "url": "https://www.uniprot.org/uniprotkb/Q32LI2" } ], "pmid": "" }, { "name": "positive regulation of reproductive process", "id": "GO:2000243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000243", "evidence": [ { "database": "UniProtKB", "id": "Q32LI2", "url": "https://www.uniprot.org/uniprotkb/Q32LI2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LI2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 242, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LI2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LI2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32LI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LI2" }, { "id": "PRU00274", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00274" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000255", "start_pos": 18, "end_pos": 240, "start_aa": "Phe", "end_aa": "Gln", "glycosite_overlap": "Asn157" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 157 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 157, "end_pos": 159 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LJ0-1", "uniprot_ac": "Q32LJ0", "uniprot_id": "SVBP_BOVIN", "mass": { "chemical_mass": 7828.0, "monoisotopic_mass": 7828.0 }, "refseq": { "ac": "NP_001035665", "name": "small vasohibin-binding protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035665" }, "gene_names": [ { "name": "SVBP", "type": "recommended", "evidence": [ { "id": "Q32LJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ0" } ] }, { "name": "CCDC23", "type": "synonym", "evidence": [ { "id": "NP_001035665", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035665" }, { "id": "Q32LJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ0" } ] }, { "name": "SVBP", "type": "synonym", "evidence": [ { "id": "NP_001035665", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035665" } ] } ], "protein_names": [ { "name": "Small vasohibin-binding protein", "type": "recommended", "evidence": [ { "id": "Q32LJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ0/entry#names_and_taxonomy" } ] }, { "name": "Coiled coil domain-containing protein 23", "type": "synonym", "evidence": [ { "id": "Q32LJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ0/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain containing 23", "type": "synonym", "evidence": [ { "id": "NP_001035665", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035665" } ] }, { "name": "coiled-coil domain-containing protein 23", "type": "synonym", "evidence": [ { "id": "NP_001035665", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035665" } ] }, { "name": "small vasohibin-binding protein", "type": "synonym", "evidence": [ { "id": "NP_001035665", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035665" } ] } ], "function": [ { "annotation": "Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin. Also required to enhance the solubility and secretion of VASH1 and VASH2. Plays a role in axon and excitatory synapse formation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ0", "url": "https://www.uniprot.org/uniprotkb/Q32LJ0#function" }, { "database": "UniProtKB", "id": "Q8N300", "url": "https://www.uniprot.org/uniprotkb/Q8N300#function" }, { "database": "UniProtKB", "id": "Q4KLG3", "url": "https://www.uniprot.org/uniprotkb/Q4KLG3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LJ0", "url": "https://www.uniprot.org/uniprotkb/Q32LJ0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SVBP", "url": "https://www.uniprot.org/uniprotkb/Q32LJ0", "locus": { "chromosome": "3", "start_pos": 103438943, "end_pos": 103432470, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017388", "url": "https://www.ensembl.org/id/ENSBTAG00000017388" } ] } } ], "crossref": [ { "id": "Q32LJ0", "url": "https://alphafold.ebi.ac.uk/entry/Q32LJ0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017388", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017388", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614073", "url": "https://www.ncbi.nlm.nih.gov/gene/614073", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614073", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614073", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AMDPPAR", "url": "https://omabrowser.org/oma/group/AMDPPAR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32LJ0", "url": "https://www.orthodb.org/?gene=Q32LJ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34762", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34762", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34762:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34762:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15674", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15674", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035665", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LJ0", "url": "https://www.uniprot.org/uniprotkb/Q32LJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LJ0-1", "url": "https://www.uniprot.org/uniprotkb/Q32LJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPPARKEKPKVKEPVSRIEKAKQKSAQQELKQRQRAEIYALNRVMTELEQQQFDEFCKQMQPPGE", "length": 66, "header": "sp|Q32LJ0-1|SVBP_BOVIN Isoform 1 of Small vasohibin-binding protein OS=Bos taurus OX=9913 GN=SVBP PE=3 SV=1 CANONICAL=Q32LJ0-1" }, "isoforms": [ { "isoform_ac": "Q32LJ0-1", "url": "https://www.uniprot.org/uniprotkb/Q32LJ0/entry#Q32LJ0-1", "sequence": { "sequence": "MDPPARKEKPKVKEPVSRIEKAKQKSAQQELKQRQRAEIYALNRVMTELEQQQFDEFCKQMQPPGE", "length": 66, "header": "sp|Q32LJ0-1|SVBP_BOVIN Isoform 1 of Small vasohibin-binding protein OS=Bos taurus OX=9913 GN=SVBP PE=3 SV=1 CANONICAL=Q32LJ0-1" }, "locus": { "chromosome": "3", "start_pos": 103438598, "end_pos": 103432966, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000042962.4", "url": "https://www.ensembl.org/id/ENSBTAT00000042962.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040566.2", "url": "https://www.ensembl.org/id/ENSBTAP00000040566.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614073", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614073", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1W748-1", "protein_name": "Uncharacterized protein", "gene_name": "SVBP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDPPARKEKSKVKEPVSRVEKAKQKSAQQELKQRQRAEIYALNRVMTELEQQQFDEFCKQMQPPGE", "length": 66 }, "evidence": [ { "id": "Q32LJ0", "url": "https://omabrowser.org/oma/group/Q32LJ0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HFF2-1", "protein_name": "Small vasohibin-binding protein", "gene_name": "Svbp", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTAGPLCRKLRLRSEEETRLGTHSEVRADQEAFTSQAMDPPARKEKSKVKEPAFRVEKTKQKSAQQELKQRQRAEIYALNRVMTELEQQQFDEFCKQMQPPGE", "length": 103 }, "evidence": [ { "id": "Q32LJ0", "url": "https://omabrowser.org/oma/group/Q32LJ0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P0C8M3-1", "protein_name": "Small vasohibin-binding protein", "gene_name": "svbp", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEPACRKDKQKQQTPTRGDRTKQKTAQQELKQRQRAEIYALNKVMTELEQQQFEAFCKQMQSQSE", "length": 65 }, "evidence": [ { "id": "Q32LJ0", "url": "https://omabrowser.org/oma/group/Q32LJ0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q4KLG3-1", "protein_name": "Small vasohibin-binding protein", "gene_name": "Svbp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDPPARKEKSKVKEPAFRVEKAKQKSAQQELKQRQRAEIYALNRVMTELEQQQFDEFCKQMQPPGE", "length": 66 }, "evidence": [ { "id": "Q32LJ0", "url": "https://omabrowser.org/oma/group/Q32LJ0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8N300-1", "protein_name": "Small vasohibin-binding protein", "gene_name": "SVBP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDPPARKEKTKVKESVSRVEKAKQKSAQQELKQRQRAEIYALNRVMTELEQQQFDEFCKQMQPPGE", "length": 66 }, "evidence": [ { "id": "Q32LJ0", "url": "https://omabrowser.org/oma/group/Q32LJ0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99LQ4-1", "protein_name": "Small vasohibin-binding protein", "gene_name": "Svbp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDPPARKEKSKVKEPAFRVEKAKQKSAQQELKQRQRAEIYALNRVMTELEQQQFDEFCKQMQPPGE", "length": 66 }, "evidence": [ { "id": "Q32LJ0", "url": "https://omabrowser.org/oma/group/Q32LJ0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ0", "url": "https://www.uniprot.org/uniprotkb/Q32LJ0" } ], "pmid": "" }, { "name": "protein secretion", "id": "GO:0009306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009306", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ0", "url": "https://www.uniprot.org/uniprotkb/Q32LJ0" } ], "pmid": "" }, { "name": "negative regulation of protein ubiquitination", "id": "GO:0031397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031397", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ0", "url": "https://www.uniprot.org/uniprotkb/Q32LJ0" } ], "pmid": "" }, { "name": "axon development", "id": "GO:0061564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061564", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ0", "url": "https://www.uniprot.org/uniprotkb/Q32LJ0" } ], "pmid": "" }, { "name": "regulation of metallopeptidase activity", "id": "GO:1905048", "url": 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"overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LJ0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LJ0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", 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"sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32LJ2-1", "uniprot_ac": "Q32LJ2", "uniprot_id": "ARFRP_BOVIN", "mass": { "chemical_mass": 22644.0, "monoisotopic_mass": 22644.0 }, "refseq": { "ac": "NP_001032696", "name": "ADP-ribosylation factor-related protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032696" }, "gene_names": [ { "name": "ARFRP1", "type": "recommended", "evidence": [ { "id": "Q32LJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ2" } ] }, { "name": "ARFRP1", "type": "synonym", "evidence": [ { "id": "NP_001032696", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032696" } ] } ], "protein_names": [ { "name": "ADP-ribosylation factor-related protein 1", "type": "recommended", "evidence": [ { "id": "Q32LJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ2/entry#names_and_taxonomy" } ] }, { "name": "ADP-ribosylation factor-related protein 1", "type": "synonym", "evidence": [ { "id": "NP_001032696", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032696" } ] }, { "name": "ARF-related protein 1", "type": "synonym", "evidence": [ { "id": "NP_001032696", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032696" }, { "id": "Q32LJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "These data suggest that lethality of Arfrp1 knockout embryos is due to a specific disruption of protein targeting, e.g., of ARL1 and Golgin-245, to the Golgi.", "evidence": [ { "database": "RefSeq", "id": "NP_001032696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032696" }, { "database": "PubMed", "id": "17127620", "url": "https://glygen.org/publication/PubMed/17127620" } ] }, { "annotation": "Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver.", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ2", "url": "https://www.uniprot.org/uniprotkb/Q32LJ2#function" }, { "database": "UniProtKB", "id": "Q8BXL7", "url": "https://www.uniprot.org/uniprotkb/Q8BXL7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LJ2", "url": "https://www.uniprot.org/uniprotkb/Q32LJ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARFRP1", "url": "https://www.uniprot.org/uniprotkb/Q32LJ2", "locus": { "chromosome": "13", "start_pos": 54057883, "end_pos": 54046888, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007497", "url": "https://www.ensembl.org/id/ENSBTAG00000007497" } ] } } ], "crossref": [ { "id": "Q32LJ2", "url": "https://alphafold.ebi.ac.uk/entry/Q32LJ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007497", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007497", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04160", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04160", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525394", "url": "https://www.ncbi.nlm.nih.gov/gene/525394", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006689", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006689", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525394", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525394", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HGFYKYM", "url": "https://omabrowser.org/oma/group/HGFYKYM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32LJ2", "url": "https://www.orthodb.org/?gene=Q32LJ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45909", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45909", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45909:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45909:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00025", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00025", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001032696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032696", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LJ2", "url": "https://www.uniprot.org/uniprotkb/Q32LJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LJ2-1", "url": "https://www.uniprot.org/uniprotkb/Q32LJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYTLLSGLYKYMFQKDEYCVLILGLDNAGKTTFLEQSKTRFNKNYKGMSLSKITTTVGLNIGTVDVGKARLMFWDLGGQEELQSLWDKYYAECHGVIYVIDSTDEERLSESKQAFEKMVTSEALDGVPILVLANKQDVETCLSIPDIKTAFSDCASKIGRRDCLTQACSALTGKGVREGIEWMVKCVVRNVHRPPRQRDIT", "length": 201, "header": "sp|Q32LJ2-1|ARFRP_BOVIN Isoform 1 of ADP-ribosylation factor-related protein 1 OS=Bos taurus OX=9913 GN=ARFRP1 PE=2 SV=1 CANONICAL=Q32LJ2-1" }, "isoforms": [ { "isoform_ac": "Q32LJ2-1", "url": "https://www.uniprot.org/uniprotkb/Q32LJ2/entry#Q32LJ2-1", "sequence": { "sequence": "MYTLLSGLYKYMFQKDEYCVLILGLDNAGKTTFLEQSKTRFNKNYKGMSLSKITTTVGLNIGTVDVGKARLMFWDLGGQEELQSLWDKYYAECHGVIYVIDSTDEERLSESKQAFEKMVTSEALDGVPILVLANKQDVETCLSIPDIKTAFSDCASKIGRRDCLTQACSALTGKGVREGIEWMVKCVVRNVHRPPRQRDIT", "length": 201, "header": "sp|Q32LJ2-1|ARFRP_BOVIN Isoform 1 of ADP-ribosylation factor-related protein 1 OS=Bos taurus OX=9913 GN=ARFRP1 PE=2 SV=1 CANONICAL=Q32LJ2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells.", "journal": "Molecular membrane biology", "date": "2006", "authors": "Zahn C, Hommel A, Lu L, Hong W, Walther DJ, Florian S, Joost HG, Schurmann A", "evidence": [ { "database": "RefSeq", "id": "NP_001032696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032696" } ], "reference": [ { "type": "PubMed", "id": "17127620", "url": "https://glygen.org/publication/PubMed/17127620" } ] } ], "pathway": [ { "id": "bta:525394", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525394", "resource": "KEGG Pathway" }, { "id": "R-BTA-6811440", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "resource": "Reactome", "description": "Retrograde transport at the Trans-Golgi-Network" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AP37-1", "protein_name": "ADP-ribosylation factor-related protein 1", "gene_name": "ARFRP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MYTLLSGLYKYMFQKDEYCILILGLDNAGKTTFLEQSKTRFNKNYKGMSLSKITTTVGLNIGTVDVGKARLMFWDLGGQEELQSLWDKYYAECHGVIYVIDSTDEERLCESKCAFEKMVTSEALDGVPILVLANKQDIETCLSIPDIKTAFSDCISKIGRRDCLTQACSALTGKGVREGIEWMVKCVVRNVHRPPRQRDIT", "length": 201 }, "evidence": [ { "id": "Q32LJ2", "url": "https://omabrowser.org/oma/group/Q32LJ2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7G493-1", "protein_name": "ADP-ribosylation factor-related protein 1 isoform X1", "gene_name": "Arfrp1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MYTLLSGLYKYMFQKDEYCILILGLDNAGKTTFLEQSKTRFNKNYKGMSLSKITTTVGLNIGTVDVGKARLMFWDLGGQEELQSLWDKYYAECHGVIYVIDSTDEERLSESKEAFEPAVMNKTWCKAPHLLLSSEKVVSSEALDGVPILVLANKQDVETCLSIPDIKTAFSDCTCKIGRRDCLTQACSALTGKGVREGIEWMVKCVVRNVHRPPRQRDIT", "length": 220 }, "evidence": [ { "id": "Q32LJ2", "url": "https://omabrowser.org/oma/group/Q32LJ2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E1C1J0-1", "protein_name": "ADP-ribosylation factor-related protein 1", "gene_name": "ARFRP1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MYTLLSGLYKYMFQRDEYCILILGLDNAGKTTFLEQTKTRFNKNYKGMSLSKITTTVGLNIGTIDVGKTRLMFWDLGGQEELQSLWDKYYAESHGVIYVIDSTDEERLSESKRAFEKMITSEALEGVPILVLANKQDVETCLSIPDIKTAFSDCINKIGKRDCLTQACSALTGKGVNEGIEWMVKCVVRNIHRPPRKKDIT", "length": 201 }, "evidence": [ { "id": "Q32LJ2", "url": "https://omabrowser.org/oma/group/Q32LJ2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E7FAS3-1", "protein_name": "ADP-ribosylation factor-related protein 1", "gene_name": "arfrp1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MYTLLSGLYKYMFQKDEYCILILGLDNAGKTTFLEQTKTRFSKNYKGMNLSKITTTVGLNIGTIDVGKARLMFWDLGGQEELQSLWDKYYAESHGVIYVIDSTDEERLGESKNAFEKMISSEALEGVPLLVLANKQDVENCLSVPDIKTAFSDCAPKIGKRDCLVQPCAALSGQGVNDGIEWMVKCVIRNIHRPPRQKDIT", "length": 201 }, "evidence": [ { "id": "Q32LJ2", "url": "https://omabrowser.org/oma/group/Q32LJ2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q02804-1", "protein_name": "ADP-ribosylation factor-like protein 3", "gene_name": "ARL3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MFHLVKGLYNNWNKKEQYSILILGLDNAGKTTFLETLKKEYSLAFKALEKIQPTVGQNVATIPVDSKQILKFWDVGGQESLRSMWSEYYSLCHGIIFIVDSSDRERLDECSTTLQSVVMDEEIEGVPILMLANKQDRQDRMEVQDIKEVFNKIAEHISARDSRVLPISALTGEGVKDAIEWMIVRLERNKKSRPPIYK", "length": 198 }, "evidence": [ { "id": "Q32LJ2", "url": "https://omabrowser.org/oma/group/Q32LJ2/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q13795-1", "protein_name": "ADP-ribosylation factor-related protein 1", "gene_name": "ARFRP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYTLLSGLYKYMFQKDEYCILILGLDNAGKTTFLEQSKTRFNKNYKGMSLSKITTTVGLNIGTVDVGKARLMFWDLGGQEELQSLWDKYYAECHGVIYVIDSTDEERLAESKQAFEKVVTSEALCGVPVLVLANKQDVETCLSIPDIKTAFSDCTSKIGRRDCLTQACSALTGKGVREGIEWMVKCVVRNVHRPPRQRDIT", "length": 201 }, "evidence": [ { "id": "Q32LJ2", "url": "https://omabrowser.org/oma/group/Q32LJ2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54QU7-1", "protein_name": "ARF-like protein", "gene_name": "arfrp1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MYSLFVGLWKYLFSKNEYFILILGLDNSGKTTLLEQIKTKYTKIPGLPPHKIVPTVGLNIARTQFQDIKLIYWDLGGQTQLRTIWNKFFSDVHAIIYVVDSSDKERFNESKDELEIVINDSKLKDVPLLLFFNKQDLPDSETIEYLSSVFKSVIQSCQLSNSTDQLSSLSSSSPITTRNVQLQPLIACKGEGLEQGINWLSDCLRKNARTIEKSDF", "length": 216 }, "evidence": [ { "id": "Q32LJ2", "url": "https://omabrowser.org/oma/group/Q32LJ2/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q63055-1", "protein_name": "ADP-ribosylation factor-related protein 1", "gene_name": "Arfrp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYTLLSGLYKYMFQKDEYCILILGLDNAGKTTFLEQSKTRFNKNYKGMSLSKITTTVGLNIGTVDVGKARLMFWDLGGQEELQSLWDKYYAECHGVIYVIDSTDEERLSESKEAFEKVVSSEALDGVPILVLANKQDVETCLSIPDIKTAFSDCTCKIGRRDCLTQACSALTGKGVREGIEWMVKCVVRNVHRPPRQRDIT", "length": 201 }, "evidence": [ { "id": "Q32LJ2", "url": "https://omabrowser.org/oma/group/Q32LJ2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BXL7-1", "protein_name": "ADP-ribosylation factor-related protein 1", "gene_name": "Arfrp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYTLLSGLYKYMFQKDEYCILILGLDNAGKTTFLEQSKTRFNKNYKGMSLSKITTTVGLNIGTVDVGKARLMFWDLGGQEELQSLWDKYYAECHGVIYVIDSTDEERLSESKEAFEKVVSSEALDGVPILVLANKQDVETCLSIPDIKTAFSDCTCKIGRRDCLTQACSALTGKGVREGIEWMVKCVVRNVHRPPRQRDIT", "length": 201 }, "evidence": [ { "id": "Q32LJ2", "url": "https://omabrowser.org/oma/group/Q32LJ2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9W389-1", "protein_name": "ADP-ribosylation factor-related protein 1", "gene_name": "Arfrp1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MYTLMHGFYKYMTQKDDYCVVILGLDNAGKTTYLEAAKTTFTRNYKGLNPSKITTTVGLNIGTIDVQGVRLNFWDLGGQQELQSLWDKYYQESHGVIYVIDSNDRERMEESKAIFDKMIKNELLSGVPLLILANKQDLPDVMGVREIKPVFQQAGALIGRRDCLTIPVSALHGEGVDEGIKWLVEAIKRHAVVRPPREND", "length": 200 }, "evidence": [ { "id": "Q32LJ2", "url": "https://omabrowser.org/oma/group/Q32LJ2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ2", "url": "https://www.uniprot.org/uniprotkb/Q32LJ2" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ2", "url": "https://www.uniprot.org/uniprotkb/Q32LJ2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ2", "url": "https://www.uniprot.org/uniprotkb/Q32LJ2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ2", "url": "https://www.uniprot.org/uniprotkb/Q32LJ2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ2", "url": "https://www.uniprot.org/uniprotkb/Q32LJ2" } ], "pmid": "" }, { "name": "Golgi to plasma membrane protein transport", "id": "GO:0043001", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043001", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ2", "url": "https://www.uniprot.org/uniprotkb/Q32LJ2" } ], "pmid": "" }, { "name": "protein localization to Golgi apparatus", "id": "GO:0034067", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034067", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ2", "url": "https://www.uniprot.org/uniprotkb/Q32LJ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32LJ2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 201, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32LJ2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32LJ2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q32LJ4-1", "uniprot_ac": "Q32LJ4", "uniprot_id": "TPRGL_BOVIN", "mass": { "chemical_mass": 30303.0, "monoisotopic_mass": 30303.0 }, "refseq": { "ac": "NP_001069886", "name": "tumor protein p63-regulated gene 1-like protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069886" }, "gene_names": [ { "name": "TPRG1L", "type": "recommended", "evidence": [ { "id": "Q32LJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ4" } ] }, { "name": "FAM79A", "type": "synonym", "evidence": [ { "id": "NP_001069886", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069886" }, { "id": "Q32LJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ4" } ] }, { "name": "MOVER", "type": "synonym", "evidence": [ { "id": "Q32LJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ4" } ] }, { "name": "TPRG1L", "type": "synonym", "evidence": [ { "id": "NP_001069886", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069886" } ] } ], "protein_names": [ { "name": "Tumor protein p63-regulated gene 1-like protein", "type": "recommended", "evidence": [ { "id": "Q32LJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ4/entry#names_and_taxonomy" } ] }, { "name": "Mossy fiber terminal-associated vertebrate-specific presynaptic protein", "type": "synonym", "evidence": [ { "id": "Q32LJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ4/entry#names_and_taxonomy" } ] }, { "name": "Protein FAM79A", "type": "synonym", "evidence": [ { "id": "Q32LJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LJ4/entry#names_and_taxonomy" } ] }, { "name": "mossy fiber terminal-associated vertebrate-specific presynaptic protein", "type": "synonym", "evidence": [ { "id": "NP_001069886", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069886" } ] }, { "name": "tumor protein p63-regulated gene 1-like protein", "type": "synonym", "evidence": [ { "id": "NP_001069886", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069886" } ] } ], "function": [ { "annotation": "Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release.", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ4", "url": "https://www.uniprot.org/uniprotkb/Q32LJ4#function" }, { "database": "UniProtKB", "id": "A8WCF8", "url": "https://www.uniprot.org/uniprotkb/A8WCF8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32LJ4", "url": "https://www.uniprot.org/uniprotkb/Q32LJ4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TPRG1L", "url": "https://www.uniprot.org/uniprotkb/Q32LJ4", "locus": { "chromosome": "16", "start_pos": 49419778, "end_pos": 49422661, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015857", "url": "https://www.ensembl.org/id/ENSBTAG00000015857" } ] } } ], "crossref": [ { "id": "Q32LJ4", "url": "https://alphafold.ebi.ac.uk/entry/Q32LJ4", "database": "AlphaFoldDB", "categories": [] }, { "id": "616333", "url": "https://www.ncbi.nlm.nih.gov/gene/616333", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR022158", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022158", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034753", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034753", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040242", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040242", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616333", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616333", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32LJ4", "url": "https://www.orthodb.org/?gene=Q32LJ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31108", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31108", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31108:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31108:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12456", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12456", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069886", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32LJ4", "url": "https://www.uniprot.org/uniprotkb/Q32LJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LJ4-1", "url": "https://www.uniprot.org/uniprotkb/Q32LJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32LJ4-2", "url": "https://www.uniprot.org/uniprotkb/Q32LJ4-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLQLRDSVDSAGTSPTALLAAGEEVGPGSGGGGGGGGRPGVGTPLRQTLWPLSVHDPTRRARVKEYFVFRPGTIEQAVEEIRVVVRPVEDGDIQGVWLLTEVDHWNNEKERLVLITDQALLICKYDFISLQCQQVVRVALNAVDTISYGEFQFPPKSLNKREGFGIRIQWDKQSRPSFISRWNPWSTSVPYTTFIEHPMAGVDEKTASLCQLDGFKALLIQAVKKAQKESPLPGQEGGVLVLECPLLIETYVGLMSFINNEAKLGYSMTRGKIGF", "length": 275, "header": "sp|Q32LJ4-1|TPRGL_BOVIN Isoform 1 of Tumor protein p63-regulated gene 1-like protein OS=Bos taurus OX=9913 GN=TPRG1L PE=2 SV=2 CANONICAL=Q32LJ4-1" }, "isoforms": [ { "isoform_ac": "Q32LJ4-1", "url": "https://www.uniprot.org/uniprotkb/Q32LJ4/entry#Q32LJ4-1", "sequence": { "sequence": "MLQLRDSVDSAGTSPTALLAAGEEVGPGSGGGGGGGGRPGVGTPLRQTLWPLSVHDPTRRARVKEYFVFRPGTIEQAVEEIRVVVRPVEDGDIQGVWLLTEVDHWNNEKERLVLITDQALLICKYDFISLQCQQVVRVALNAVDTISYGEFQFPPKSLNKREGFGIRIQWDKQSRPSFISRWNPWSTSVPYTTFIEHPMAGVDEKTASLCQLDGFKALLIQAVKKAQKESPLPGQEGGVLVLECPLLIETYVGLMSFINNEAKLGYSMTRGKIGF", "length": 275, "header": "sp|Q32LJ4-1|TPRGL_BOVIN Isoform 1 of Tumor protein p63-regulated gene 1-like protein OS=Bos taurus OX=9913 GN=TPRG1L PE=2 SV=2 CANONICAL=Q32LJ4-1" }, "locus": {} }, { "isoform_ac": "Q32LJ4-2", "url": "https://www.uniprot.org/uniprotkb/Q32LJ4/entry#Q32LJ4-2", "sequence": { "sequence": "MLQLRDSVDSAGTSPTALLAAGEEPGTIEQAVEEIRVVVRPVEDGDIQGVWLLTEVDHWNNEKERLVLITDQALLICKYDFISLQCQQVVRVALNAVDTISYGEFQFPPKSLNKREGFGIRIQWDKQSRPSFISRWNPWSTSVPYTTFIEHPMAGVDEKTASLCQLDGFKALLIQAVKKAQKESPLPGQEGGVLVLECPLLIETYVGLMSFINNEAKLGYSMTRGKIGF", "length": 229, "header": "sp|Q32LJ4-2|TPRGL_BOVIN Isoform 2 of Tumor protein p63-regulated gene 1-like protein OS=Bos taurus OX=9913 GN=TPRG1L PE=2 SV=2 CANONICAL=Q32LJ4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 10, "end_pos": 10, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32LJ4", "url": "https://www.uniprot.org/uniprotkb/Q32LJ4" } ], "site_lbl": "Ser10" }, { "start_pos": 14, "end_pos": 14, 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Required for proper retrograde ciliary transport.", "evidence": [ { "database": "UniProtKB", "id": "Q32P71", "url": "https://www.uniprot.org/uniprotkb/Q32P71#function" }, { "database": "UniProtKB", "id": "Q8WW35", "url": "https://www.uniprot.org/uniprotkb/Q8WW35#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32P71", "url": "https://www.uniprot.org/uniprotkb/Q32P71" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DYNLT2B", "url": "https://www.uniprot.org/uniprotkb/Q32P71", "locus": {} } ], "crossref": [ { "id": "Q32P71", "url": "https://alphafold.ebi.ac.uk/entry/Q32P71", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd21459", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21459", "database": "CDD", "categories": [ 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"PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21255:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21255:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF03645", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03645", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001160027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160027", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32P71", "url": "https://www.uniprot.org/uniprotkb/Q32P71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32P71-1", "url": "https://www.uniprot.org/uniprotkb/Q32P71-1", "database": "UniProtKB", 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"", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504554", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32P71", "url": "https://www.uniprot.org/uniprotkb/Q32P71" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "Q32P71", "url": "https://www.uniprot.org/uniprotkb/Q32P71" } ], "pmid": "" }, { "name": "cytoplasmic dynein complex", "id": "GO:0005868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005868", "evidence": [ { "database": "UniProtKB", "id": "Q32P71", "url": "https://www.uniprot.org/uniprotkb/Q32P71" } ], "pmid": "" }, { "name": "dynein axonemal particle", "id": "GO:0120293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120293", "evidence": [ { "database": "UniProtKB", "id": "Q32P71", "url": "https://www.uniprot.org/uniprotkb/Q32P71" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "microtubule-based movement", "id": "GO:0007018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007018", "evidence": [ { "database": "UniProtKB", "id": "Q32P71", "url": "https://www.uniprot.org/uniprotkb/Q32P71" } ], "pmid": "" }, { "name": "intraciliary retrograde transport", "id": "GO:0035721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035721", "evidence": [ { "database": "UniProtKB", "id": "Q32P71", "url": "https://www.uniprot.org/uniprotkb/Q32P71" } ], "pmid": "" }, { "name": "regulation of intraciliary retrograde transport", "id": "GO:1905799", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905799", "evidence": [ { "database": "UniProtKB", "id": "Q32P71", "url": "https://www.uniprot.org/uniprotkb/Q32P71" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "dynein intermediate chain binding", "id": "GO:0045505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045505", "evidence": [ { "database": "UniProtKB", "id": "Q32P71", "url": "https://www.uniprot.org/uniprotkb/Q32P71" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" }, { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32P71-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 152, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32P71-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32P71" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 129, "end_pos": 131 }, { "start_pos": 137, "end_pos": 139 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", 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"sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32P79-1", "uniprot_ac": "Q32P79", "uniprot_id": "RPB11_BOVIN", "mass": { "chemical_mass": 13293.0, "monoisotopic_mass": 13293.0 }, "refseq": { "ac": "NP_001032560", "name": "DNA-directed RNA polymerase II subunit RPB11", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032560" }, "gene_names": [ { "name": "POLR2J", "type": "recommended", "evidence": [ { "id": "Q32P79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P79" } ] }, { "name": "POLR2J2", "type": "synonym", "evidence": [ { "id": "NP_001032560", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032560" } ] }, { "name": "POLR2J", "type": "synonym", "evidence": [ { "id": "NP_001032560", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032560" } ] } ], "protein_names": [ { "name": "DNA-directed RNA polymerase II subunit RPB11", "type": "recommended", "evidence": [ { "id": "Q32P79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P79/entry#names_and_taxonomy" } ] }, { "name": "DNA directed RNA polymerase II polypeptide J-related", "type": "synonym", "evidence": [ { "id": "NP_001032560", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032560" } ] }, { "name": "DNA directed RNA polymerase II polypeptide J", "type": "synonym", "evidence": [ { "id": "NP_001032560", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032560" } ] }, { "name": "DNA-directed RNA polymerase II subunit J", "type": "synonym", "evidence": [ { "id": "NP_001032560", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032560" }, { "id": "Q32P79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P79/entry#names_and_taxonomy" } ] }, { "name": "DNA-directed RNA polymerase II subunit RPB11", "type": "synonym", "evidence": [ { "id": "NP_001032560", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032560" } ] }, { "name": "RNA polymerase II subunit B11", "type": "synonym", "evidence": [ { "id": "NP_001032560", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032560" }, { "id": "Q32P79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P79/entry#names_and_taxonomy" } ] }, { "name": "polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa", "type": "synonym", "evidence": [ { "id": "NP_001032560", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032560" } ] } ], "function": [ { "annotation": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. 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"recommended", "evidence": [ { "id": "Q32P84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P84" } ] }, { "name": "C11orf10", "type": "synonym", "evidence": [ { "id": "NP_001181992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181992" } ] }, { "name": "C29H11orf10", "type": "synonym", "evidence": [ { "id": "NP_001181992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181992" } ] }, { "name": "TMEM258", "type": "synonym", "evidence": [ { "id": "NP_001181992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181992" } ] } ], "protein_names": [ { "name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258", "type": "recommended", "evidence": [ { "id": "Q32P84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P84/entry#names_and_taxonomy" } ] }, { "name": "Oligosaccharyl transferase subunit TMEM258", "type": "synonym", "evidence": [ { "id": "Q32P84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P84/entry#names_and_taxonomy" } ] }, { "name": "Transmembrane protein 258", "type": "synonym", "evidence": [ { "id": "Q32P84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P84/entry#names_and_taxonomy" } ] }, { "name": "UPF0197 transmembrane protein C11orf10 homolog", "type": "synonym", "evidence": [ { "id": "NP_001181992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181992" } ] }, { "name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258", "type": "synonym", "evidence": [ { "id": "NP_001181992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181992" } ] }, { "name": "oligosaccharyl transferase subunit TMEM258", "type": "synonym", "evidence": [ { "id": "NP_001181992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181992" } ] } ], "function": [ { "annotation": 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N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Involved in ER homeostasis in the colonic epithelium (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32P84", "url": "https://www.uniprot.org/uniprotkb/Q32P84#function" }, { "database": "UniProtKB", "id": "P61165", "url": "https://www.uniprot.org/uniprotkb/P61165#function" }, { "database": "UniProtKB", "id": "P61166", "url": "https://www.uniprot.org/uniprotkb/P61166#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32P84", "url": "https://www.uniprot.org/uniprotkb/Q32P84" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM258", "url": "https://www.uniprot.org/uniprotkb/Q32P84", "locus": { "chromosome": "29", "start_pos": 40232832, "end_pos": 40236557, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": 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}, { "id": "Q32P84-1", "url": "https://www.uniprot.org/uniprotkb/Q32P84-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELEAMSRYTSPVNPAVFPHLTVVLLAIGMFFTAWFFVYEVTSTKYTRDIYKELLISLVASLFMGFGVLFLLLWVGIYI", "length": 79, "header": "sp|Q32P84-1|TM258_BOVIN Isoform 1 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258 OS=Bos taurus OX=9913 GN=TMEM258 PE=3 SV=1 CANONICAL=Q32P84-1" }, "isoforms": [ { "isoform_ac": "Q32P84-1", "url": "https://www.uniprot.org/uniprotkb/Q32P84/entry#Q32P84-1", "sequence": { "sequence": "MELEAMSRYTSPVNPAVFPHLTVVLLAIGMFFTAWFFVYEVTSTKYTRDIYKELLISLVASLFMGFGVLFLLLWVGIYI", "length": 79, "header": "sp|Q32P84-1|TM258_BOVIN Isoform 1 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258 OS=Bos taurus OX=9913 GN=TMEM258 PE=3 SV=1 CANONICAL=Q32P84-1" }, "locus": { "chromosome": "29", "start_pos": 40236471, "end_pos": 40233458, "strand": "+", "evidence": [ { "database": "Ensembl 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"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258", "gene_name": "tmem258", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MELEAMTRYTSPVNPAVFPHLTVVLLAIGMFFKAWFFVYEVTSTKYTRDVYKELLIALVASLFMGFGVHFLLLWVGIFV", "length": 79 }, "evidence": [ { "id": "Q32P84", "url": "https://omabrowser.org/oma/group/Q32P84/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q76LT9-1", "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258", "gene_name": "TMEM258", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MELEAMSRYTSPVNPAVFPHLTVVLLAIGMFFTAWFFVYEVTSTKYTRDIYKELLISLVASLFMGFGVLFLLLWVGIYV", "length": 79 }, "evidence": [ { "id": "Q32P84", "url": "https://omabrowser.org/oma/group/Q32P84/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9VVA8-1", "protein_name": "Transmembrane protein 258", "gene_name": "kud", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDVMQRYVSPVNPAVFPHLATVLLVIGTFFTAWFFIFVVSRKSSKESTLIKELLISLCASIFLGFGIVFLLLTVGIYV", "length": 78 }, "evidence": [ { "id": "Q32P84", "url": "https://omabrowser.org/oma/group/Q32P84/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32P84", "url": "https://www.uniprot.org/uniprotkb/Q32P84" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q32P84", "url": "https://www.uniprot.org/uniprotkb/Q32P84" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": 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[9913]" } ], "gene": [ { "name": "SPACA4", "url": "https://www.uniprot.org/uniprotkb/Q32PB3", "locus": { "chromosome": "18", "start_pos": 55253024, "end_pos": 55252155, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000048127", "url": "https://www.ensembl.org/id/ENSBTAG00000048127" } ] } } ], "crossref": [ { "id": "Q32PB3", "url": "https://alphafold.ebi.ac.uk/entry/Q32PB3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000048127", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000048127", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23574", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23574", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "767953", "url": "https://www.ncbi.nlm.nih.gov/gene/767953", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016054", "database": "InterPro", 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"length": 126, "header": "sp|Q32PB3-1|SACA4_BOVIN Isoform 1 of Sperm acrosome membrane-associated protein 4 OS=Bos taurus OX=9913 GN=SPACA4 PE=2 SV=1 CANONICAL=Q32PB3-1" }, "isoforms": [ { "isoform_ac": "Q32PB3-1", "url": "https://www.uniprot.org/uniprotkb/Q32PB3/entry#Q32PB3-1", "sequence": { "sequence": "MVLGWLPLLVMVLAPGTTGVKDCVFCELTDSTSCPGTSMRCGDDEDCFTGHGVAPGVGPIINKGCVHATSCGHEEPINYMGVTYSLTTNCCTGHMCNGAPDPTRGRLAGAAASLALGVLLLLQHVL", "length": 126, "header": "sp|Q32PB3-1|SACA4_BOVIN Isoform 1 of Sperm acrosome membrane-associated protein 4 OS=Bos taurus OX=9913 GN=SPACA4 PE=2 SV=1 CANONICAL=Q32PB3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767953", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767953", "resource": "KEGG Pathway" }, { "id": "R-BTA-163125", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "resource": "Reactome", "description": "Post-translational modification: synthesis of GPI-anchored proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZT54-1", "protein_name": "Sperm acrosome associated 4", "gene_name": "Spaca4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVFGWLLLLVLVLCPGGTGIKDCVFCELTDSARCPGTHMRCGDDEDCFIGHGVAQGVGPIINKGCVHSTNCGREEPISYMGLTYSLTTTCCSGHLCNGGAGLATGATSLSLGLQLLRGLLLLLQYWP", "length": 127 }, "evidence": [ { "id": "Q32PB3", "url": "https://omabrowser.org/oma/group/Q32PB3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HZW1-1", "protein_name": "Sperm acrosome membrane-associated protein 4", "gene_name": "Spaca4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVLGWPLLLVLVLCPGATGIKDCVFCELTDSTQCPGSHMSCGDDEDCFTGHGVAQGVGPIINKGCVHSTSCGREEPVSYMGLTYSLTTTCCSGHLCNGGAGSATGPASLVLGLQLLLGLLLLLQYWL", "length": 127 }, "evidence": [ { "id": "Q32PB3", "url": "https://omabrowser.org/oma/group/Q32PB3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q80ZQ0-1", "protein_name": "Sperm acrosome membrane-associated protein 4", "gene_name": "Spaca4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVLGWPLLLVLVLCPGVTGIKDCVFCELTDSARCPGTHMRCGDDEDCFTGHGVAQGVGPIINKGCVHSTSCGREEPISYMGLTYSLTTTCCSGHLCNKGTGLSTGATSLSLGLQLLLGLLLLLQYWL", "length": 127 }, "evidence": [ { "id": "Q32PB3", "url": "https://omabrowser.org/oma/group/Q32PB3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TDM5-1", "protein_name": "Sperm acrosome membrane-associated protein 4", "gene_name": "SPACA4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVLCWLLLLVMALPPGTTGVKDCVFCELTDSMQCPGTYMHCGDDEDCFTGHGVAPGTGPVINKGCLRATSCGLEEPVSYRGVTYSLTTNCCTGRLCNRAPSSQTVGATTSLALGLGMLLPPRLL", "length": 124 }, "evidence": [ { "id": "Q32PB3", "url": "https://omabrowser.org/oma/group/Q32PB3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "sperm-egg recognition", "id": "GO:0035036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035036", "evidence": [ { "database": "UniProtKB", "id": "Q32PB3", "url": "https://www.uniprot.org/uniprotkb/Q32PB3" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "Q32PB3", "url": "https://www.uniprot.org/uniprotkb/Q32PB3" } ], "pmid": "" }, { "name": "binding of sperm to zona pellucida", "id": "GO:0007339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007339", "evidence": [ { "database": "UniProtKB", "id": "Q32PB3", "url": "https://www.uniprot.org/uniprotkb/Q32PB3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q32PB3", "url": "https://www.uniprot.org/uniprotkb/Q32PB3" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q32PB3", "url": "https://www.uniprot.org/uniprotkb/Q32PB3" } ], "pmid": "" }, { "name": "inner acrosomal membrane", "id": "GO:0002079", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002079", "evidence": [ { "database": "UniProtKB", "id": "Q32PB3", "url": "https://www.uniprot.org/uniprotkb/Q32PB3" } ], "pmid": "" }, { "name": "outer acrosomal membrane", "id": "GO:0002081", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002081", "evidence": [ { "database": "UniProtKB", "id": "Q32PB3", "url": "https://www.uniprot.org/uniprotkb/Q32PB3" } ], "pmid": "" }, { "name": "side of membrane", "id": "GO:0098552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098552", "evidence": [ { "database": "UniProtKB", "id": "Q32PB3", "url": "https://www.uniprot.org/uniprotkb/Q32PB3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PB3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 126, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PB3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PB3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32PB4-1", "uniprot_ac": "Q32PB4", "uniprot_id": "NUPR2_BOVIN", "mass": { "chemical_mass": 11522.0, "monoisotopic_mass": 11522.0 }, "refseq": { "ac": "NP_001035664", "name": "nuclear protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035664" }, "gene_names": [ { "name": "NUPR2", "type": "recommended", "evidence": [ { "id": "Q32PB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PB4" } ] }, { "name": "NUPR1L", "type": "synonym", "evidence": [ { "id": "NP_001035664", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035664" }, { "id": "Q32PB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PB4" } ] }, { "name": "NUPR2", "type": "synonym", "evidence": [ { "id": "NP_001035664", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035664" } ] } ], "protein_names": [ { "name": "Nuclear protein 2", "type": "recommended", "evidence": [ { "id": "Q32PB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PB4/entry#names_and_taxonomy" } ] }, { "name": "Nuclear transcriptional regulator 1-like protein", "type": "synonym", "evidence": [ { "id": "Q32PB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PB4/entry#names_and_taxonomy" } ] }, { "name": "Nuclear transcriptional regulator protein 2", "type": "synonym", "evidence": [ { "id": "Q32PB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PB4/entry#names_and_taxonomy" } ] }, { "name": "nuclear protein 2", "type": "synonym", "evidence": [ { "id": "NP_001035664", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035664" } ] }, { "name": "nuclear protein, transcriptional regulator, 1-like", "type": "synonym", "evidence": [ { "id": "NP_001035664", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035664" } ] }, { "name": "nuclear transcriptional regulator 1-like protein", "type": "synonym", "evidence": [ { "id": "NP_001035664", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035664" } ] }, { "name": "nuclear transcriptional regulator protein 2", "type": "synonym", "evidence": [ { "id": "NP_001035664", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035664" } ] } ], "function": [ { "annotation": "Acts as a transcriptional repressor by inhibiting gene expression at the NUPR1 promoter in a p53/TP53-dependent manner in cancer cells. Involved in the G1 cell cycle arrest, and in a decrease in cell viability and cell proliferation. Plays a role as a negative regulator of the protumoral factor NUPR1.", "evidence": [ { "database": "UniProtKB", "id": "Q32PB4", "url": "https://www.uniprot.org/uniprotkb/Q32PB4#function" }, { "database": "UniProtKB", "id": "A6NF83", "url": "https://www.uniprot.org/uniprotkb/A6NF83#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PB4", "url": "https://www.uniprot.org/uniprotkb/Q32PB4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NUPR2", "url": "https://www.uniprot.org/uniprotkb/Q32PB4", "locus": {} } ], "crossref": [ { "id": "Q32PB4", "url": "https://alphafold.ebi.ac.uk/entry/Q32PB4", "database": "AlphaFoldDB", "categories": [] }, { "id": "614047", "url": "https://www.ncbi.nlm.nih.gov/gene/614047", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018792", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018792", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614047", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614047", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32PB4", "url": "https://www.orthodb.org/?gene=Q32PB4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR17149", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17149", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR17149:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17149:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10195", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10195", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035664", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32PB4", "url": "https://www.uniprot.org/uniprotkb/Q32PB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PB4-1", "url": "https://www.uniprot.org/uniprotkb/Q32PB4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPAAPTVQPRAQPPPPDVWPPVGSEEEFYDCPDYYYLRDFPACGAGRINGRTRRERELRTNWLVPGGHERKIAQKLLNSQRKRRQRQLQPRPRTRLT", "length": 98, "header": "sp|Q32PB4-1|NUPR2_BOVIN Isoform 1 of Nuclear protein 2 OS=Bos taurus OX=9913 GN=NUPR2 PE=3 SV=1 CANONICAL=Q32PB4-1" }, "isoforms": [ { "isoform_ac": "Q32PB4-1", "url": "https://www.uniprot.org/uniprotkb/Q32PB4/entry#Q32PB4-1", "sequence": { "sequence": "MEPAAPTVQPRAQPPPPDVWPPVGSEEEFYDCPDYYYLRDFPACGAGRINGRTRRERELRTNWLVPGGHERKIAQKLLNSQRKRRQRQLQPRPRTRLT", "length": 98, "header": "sp|Q32PB4-1|NUPR2_BOVIN Isoform 1 of Nuclear protein 2 OS=Bos taurus OX=9913 GN=NUPR2 PE=3 SV=1 CANONICAL=Q32PB4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614047", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614047", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q32PB4", "url": "https://www.uniprot.org/uniprotkb/Q32PB4" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q32PB4", "url": "https://www.uniprot.org/uniprotkb/Q32PB4" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0045786", "evidence": [ { "database": "UniProtKB", "id": "Q32PB4", "url": "https://www.uniprot.org/uniprotkb/Q32PB4" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "Q32PB4", "url": "https://www.uniprot.org/uniprotkb/Q32PB4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32PB4", "url": "https://www.uniprot.org/uniprotkb/Q32PB4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PB4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 98, "overlap": "1.0", 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"length": 87 }, "evidence": [ { "id": "Q32PB8", "url": "https://omabrowser.org/oma/group/Q32PB8/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54BN4-1", "protein_name": "Small ribosomal subunit protein eS21", "gene_name": "rps21", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDSKNVELYTPRKCSATNRLITAKDHASVQINIGHVNAEGIYNGEQTIFAFCGFLRNNGQSDAALNRLAQQKGFLKSF", "length": 78 }, "evidence": [ { "id": "Q32PB8", "url": "https://omabrowser.org/oma/group/Q32PB8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q7ZUG5-1", "protein_name": "Small ribosomal subunit protein eS21", "gene_name": "rps21", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MQNDAGEFVDLYVPRKCSASNRIIGAKDHASIQINIAEVDRVTGRFNGQFKTYAICGAIRRMGEADDSLLRLAKTDSIVAK", "length": 81 }, "evidence": [ { "id": "Q32PB8", "url": "https://omabrowser.org/oma/group/Q32PB8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9CQR2-1", "protein_name": "Small ribosomal subunit protein eS21", "gene_name": "Rps21", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQNDAGEFVDLYVPRKCSASNRIIAAKDHASIQMNVAEVDRTTGRFNGQFKTYGICGAIRRMGESDDSILRLAKADGIVSKNF", "length": 83 }, "evidence": [ { "id": "Q32PB8", "url": "https://omabrowser.org/oma/group/Q32PB8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9M337-1", "protein_name": "Small ribosomal subunit protein eS21z", "gene_name": "RPS21B", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MENDAGQVTELYIPRKCSATNRMITSKDHASVQLNIGHLDANGLYTGQFTTFALCGFVRAQGDADSGVDRLWQKKKVEAKQQ", "length": 82 }, "evidence": [ { "id": "Q32PB8", "url": "https://omabrowser.org/oma/group/Q32PB8/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "rough endoplasmic reticulum", "id": "GO:0005791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005791", "evidence": [ { "database": "UniProtKB", "id": "Q32PB8", "url": "https://www.uniprot.org/uniprotkb/Q32PB8" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "Q32PB8", "url": "https://www.uniprot.org/uniprotkb/Q32PB8" } ], "pmid": "" }, { "name": "cytosolic small ribosomal subunit", "id": "GO:0022627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022627", "evidence": [ { "database": "UniProtKB", "id": "Q32PB8", "url": "https://www.uniprot.org/uniprotkb/Q32PB8" } ], "pmid": "" }, { "name": "cytosolic ribosome", "id": "GO:0022626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022626", "evidence": [ { "database": "UniProtKB", "id": "Q32PB8", "url": "https://www.uniprot.org/uniprotkb/Q32PB8" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q32PB8", "url": "https://www.uniprot.org/uniprotkb/Q32PB8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "id": "GO:0000447", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000447", "evidence": [ { "database": "UniProtKB", "id": "Q32PB8", "url": "https://www.uniprot.org/uniprotkb/Q32PB8" } ], "pmid": "" }, { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "Q32PB8", "url": "https://www.uniprot.org/uniprotkb/Q32PB8" } ], "pmid": "" }, { "name": "endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "id": "GO:0000461", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000461", "evidence": [ { "database": "UniProtKB", "id": "Q32PB8", "url": "https://www.uniprot.org/uniprotkb/Q32PB8" } ], "pmid": "" }, { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q32PB8", "url": "https://www.uniprot.org/uniprotkb/Q32PB8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q32PB8", "url": "https://www.uniprot.org/uniprotkb/Q32PB8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], 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"monoisotopic_mass": 17580.0 }, "refseq": { "ac": "NP_001035626", "name": "sperm acrosome-associated protein 5 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035626" }, "gene_names": [ { "name": "SPACA5", "type": "recommended", "evidence": [ { "id": "Q32PD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PD6" } ] }, { "name": "LYZE", "type": "synonym", "evidence": [ { "id": "NP_001035626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035626" } ] }, { "name": "LYZL5", "type": "synonym", "evidence": [ { "id": "Q32PD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PD6" } ] }, { "name": "SPACA5", "type": "synonym", "evidence": [ { "id": "NP_001035626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035626" } ] } ], "protein_names": [ { "name": "Sperm acrosome-associated protein 5", "type": "recommended", "evidence": [ { "id": "Q32PD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PD6/entry#names_and_taxonomy" } ] }, { "name": "3.2.1.17", "type": "synonym", "evidence": [ { "id": "Q32PD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PD6/entry#names_and_taxonomy" } ] }, { "name": "Lysozyme-like protein 5", "type": "synonym", "evidence": [ { "id": "Q32PD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PD6/entry#names_and_taxonomy" } ] }, { "name": "lysozyme E", "type": "synonym", "evidence": [ { "id": "NP_001035626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035626" } ] }, { "name": "lysozyme-like protein 5", "type": "synonym", "evidence": [ { "id": "NP_001035626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035626" } ] }, { "name": "sperm acrosome-associated protein 5 precursor", "type": "synonym", "evidence": [ { "id": "NP_001035626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035626" } ] }, { "name": "sperm acrosome-associated protein 5", "type": "synonym", "evidence": [ { "id": "NP_001035626", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035626" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PD6", "url": "https://www.uniprot.org/uniprotkb/Q32PD6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPACA5", "url": "https://www.uniprot.org/uniprotkb/Q32PD6", "locus": { "chromosome": "X", "start_pos": 86454588, "end_pos": 86452251, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046069", "url": "https://www.ensembl.org/id/ENSBTAG00000046069" } ] } } ], "crossref": [ { "id": "Q32PD6", "url": "https://alphafold.ebi.ac.uk/entry/Q32PD6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046069", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046069", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16897", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16897", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517880", "url": "https://www.ncbi.nlm.nih.gov/gene/517880", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001916", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001916", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023346", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023346", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517880", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517880", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AWWCNNG", "url": "https://omabrowser.org/oma/group/AWWCNNG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32PD6", "url": "https://www.orthodb.org/?gene=Q32PD6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11407", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11407", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11407:SF31", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11407:SF31", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00062", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00062", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035626", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32PD6", "url": "https://www.uniprot.org/uniprotkb/Q32PD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PD6-1", "url": "https://www.uniprot.org/uniprotkb/Q32PD6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQVSGTIVVILMAANVEAKIYERCDLAKKLEAAGLNGFKGYTIGDWLCMAHYESGFDTSFVNHNPDGSSEYGIFQLNSAWWCYNGVTPSENLCHMDCHELLNRHILDDIMCAKKVVSSESGMSAWDSWNQHCYGYDLSEWLRGCHMNAKPNKKIIS", "length": 156, "header": "sp|Q32PD6-1|LYZL5_BOVIN Isoform 1 of Sperm acrosome-associated protein 5 OS=Bos taurus OX=9913 GN=SPACA5 PE=2 SV=1 CANONICAL=Q32PD6-1" }, "isoforms": [ { "isoform_ac": "Q32PD6-1", "url": "https://www.uniprot.org/uniprotkb/Q32PD6/entry#Q32PD6-1", "sequence": { "sequence": "MQVSGTIVVILMAANVEAKIYERCDLAKKLEAAGLNGFKGYTIGDWLCMAHYESGFDTSFVNHNPDGSSEYGIFQLNSAWWCYNGVTPSENLCHMDCHELLNRHILDDIMCAKKVVSSESGMSAWDSWNQHCYGYDLSEWLRGCHMNAKPNKKIIS", "length": 156, "header": "sp|Q32PD6-1|LYZL5_BOVIN Isoform 1 of Sperm acrosome-associated protein 5 OS=Bos taurus OX=9913 GN=SPACA5 PE=2 SV=1 CANONICAL=Q32PD6-1" }, "locus": { "chromosome": "X", "start_pos": 86454501, "end_pos": 86452309, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063388.2", "url": "https://www.ensembl.org/id/ENSBTAT00000063388.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055963.1", "url": "https://www.ensembl.org/id/ENSBTAP00000055963.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 87, "start_aa": "Thr", "end_pos": 87, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr87", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycohydrolase-activity", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:517880", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517880", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A2AE20-1", "protein_name": "Sperm acrosome-associated protein 5", "gene_name": "Spaca5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKVCSIVVVILAVLLIAKLDAKIYERCELAKKLEEAGLDGFKGYTVGDWLCVAHYESGFDTSFVDHNPDGSSEYGIFQLNSAWWCNNGITPTQNLCNIDCNDLLNRHILDDIICAKRVASSHKSMKAWDSWTQHCAGHDLSEWLKGCSVRLKTDSSYNNW", "length": 160 }, "evidence": [ { "id": "Q32PD6", "url": "https://omabrowser.org/oma/group/Q32PD6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "M0RCC1-1", "protein_name": "Sperm acrosome associated 5", "gene_name": "Spaca5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLVFFFLLVFNRVCIQESGSAPSHVAHMFQNLSFRLVLIKPSILECYSLFLIITGSEARDHIEGFLAAMQFCSTVVVILATLLLATVDAKIYERCELARKLEKAGLNGFKGYTVGDWLCVAHYESGFDTSFVDHNPDGSSEYGIFQLNSAWWCNNGITPTQNLCHMDCNDLLNRHILDDIMCAKRVVSSHKSMKAWDSWTRHCAGHDLSEWLKGCDVPLKADSNYDDW", "length": 228 }, "evidence": [ { "id": "Q32PD6", "url": "https://omabrowser.org/oma/group/Q32PD6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96QH8-1", "protein_name": "Sperm acrosome-associated protein 5", "gene_name": "SPACA5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKAWGTVVVTLATLMVVTVDAKIYERCELAARLERAGLNGYKGYGVGDWLCMAHYESGFDTAFVDHNPDGSSEYGIFQLNSAWWCDNGITPTKNLCHMDCHDLLNRHILDDIRCAKQIVSSQNGLSAWTSWRLHCSGHDLSEWLKGCDMHVKIDPKIHP", "length": 159 }, "evidence": [ { "id": "Q32PD6", "url": "https://omabrowser.org/oma/group/Q32PD6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": 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"evidence": [ { "database": "UniProtKB", "id": "Q32PD6", "url": "https://www.uniprot.org/uniprotkb/Q32PD6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lysozyme activity", "id": "GO:0003796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003796", "evidence": [ { "database": "UniProtKB", "id": "Q32PD6", "url": "https://www.uniprot.org/uniprotkb/Q32PD6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PD6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 156, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PD6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PD6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32PD6", 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], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3U898-1", "protein_name": "COP9 signalosome complex subunit 9", "gene_name": "Cops9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKPAVDEMFPEGAGPYVDLDEAGGSTGLLMDLAANEKAVHADFFNDFEDLFDDDDVQ", "length": 57 }, "evidence": [ { "id": "Q32PD7", "url": "https://omabrowser.org/oma/group/Q32PD7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6P6E6-1", "protein_name": "COP9 signalosome complex subunit 9", "gene_name": "cops9", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKPAVDEMFPEGAGPYVDLDEAGGSSGLLMDLAANEKAVHSDFFNDFEDLFDDDDIQ", "length": 57 }, "evidence": [ { "id": "Q32PD7", "url": "https://omabrowser.org/oma/group/Q32PD7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q7JVR7-1", "protein_name": "COP9 signalosome complex subunit 9 homolog", 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"name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "Q32PD7", "url": "https://www.uniprot.org/uniprotkb/Q32PD7" } ], "pmid": "" }, { "name": "cellular response to UV", "id": "GO:0034644", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034644", "evidence": [ { "database": "UniProtKB", "id": "Q32PD7", "url": "https://www.uniprot.org/uniprotkb/Q32PD7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PD7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 57, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PD7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PD7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 26 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32PE2-1", "uniprot_ac": "Q32PE2", "uniprot_id": "MOG1_BOVIN", "mass": { "chemical_mass": 20680.0, "monoisotopic_mass": 20680.0 }, "refseq": { "ac": "NP_001032537", "name": "ran guanine nucleotide release factor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032537" }, "gene_names": [ { "name": "RANGRF", "type": "recommended", "evidence": [ { "id": "Q32PE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PE2" } ] }, { "name": "MOG1", "type": "synonym", "evidence": [ { "id": "Q32PE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PE2" } ] }, { "name": "RANGNRF", "type": "synonym", "evidence": [ { "id": "NP_001032537", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032537" }, { "id": "Q32PE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PE2" } ] }, { "name": "RANGRF", "type": "synonym", "evidence": [ { "id": "NP_001032537", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032537" } ] } ], "protein_names": [ { "name": "Ran guanine nucleotide release factor", "type": "recommended", "evidence": [ { "id": "Q32PE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PE2/entry#names_and_taxonomy" } ] }, { "name": "Ran-binding protein MOG1", "type": "synonym", "evidence": [ { "id": "Q32PE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PE2/entry#names_and_taxonomy" } ] }, { "name": "RanGNRF", "type": "synonym", "evidence": [ { "id": "Q32PE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PE2/entry#names_and_taxonomy" } ] }, { "name": "ran guanine nucleotide release factor", "type": "synonym", "evidence": [ { "id": "NP_001032537", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032537" } ] }, { "name": "ran-binding protein MOG1", "type": "synonym", "evidence": [ { "id": "NP_001032537", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032537" } ] } ], "function": [ { "annotation": "May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics. Enhances the expression of SCN5A at the cell membrane in cardiomyocytes.", "evidence": [ { "database": "UniProtKB", "id": "Q32PE2", "url": "https://www.uniprot.org/uniprotkb/Q32PE2#function" }, { "database": "UniProtKB", "id": "Q9HD47", "url": "https://www.uniprot.org/uniprotkb/Q9HD47#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PE2", "url": "https://www.uniprot.org/uniprotkb/Q32PE2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RANGRF", "url": "https://www.uniprot.org/uniprotkb/Q32PE2", "locus": { "chromosome": "19", "start_pos": 27905330, "end_pos": 27903909, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018809", "url": "https://www.ensembl.org/id/ENSBTAG00000018809" } ] } } ], "crossref": [ { "id": "Q32PE2", "url": "https://alphafold.ebi.ac.uk/entry/Q32PE2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00224", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00224", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512506", "url": "https://www.ncbi.nlm.nih.gov/gene/512506", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007681", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007681", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512506", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512506", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32PE2", "url": "https://www.orthodb.org/?gene=Q32PE2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15837", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15837", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15837:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15837:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04603", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04603", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032537", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32PE2", "url": "https://www.uniprot.org/uniprotkb/Q32PE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PE2-1", "url": "https://www.uniprot.org/uniprotkb/Q32PE2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPTRDNPLFGGAFSATLPPGAIDVSDLRPVPDHQEVFCHRVTDQSLIVELLELQAHVQGEEAARYHFEDVGGVQEARAVQVETVQPLVLEKLALRGCCQEAWILSGQQQVAKENQQVAKYVTLHQALLRLPQYQTDLLLTFNQPPPENRSSLGPENLSIPPWSLGDFEQLVTSLTLHDPNIFGPE", "length": 186, "header": "sp|Q32PE2-1|MOG1_BOVIN Isoform 1 of Ran guanine nucleotide release factor OS=Bos taurus OX=9913 GN=RANGRF PE=2 SV=1 CANONICAL=Q32PE2-1" }, "isoforms": [ { "isoform_ac": "Q32PE2-1", "url": "https://www.uniprot.org/uniprotkb/Q32PE2/entry#Q32PE2-1", "sequence": { "sequence": "MEPTRDNPLFGGAFSATLPPGAIDVSDLRPVPDHQEVFCHRVTDQSLIVELLELQAHVQGEEAARYHFEDVGGVQEARAVQVETVQPLVLEKLALRGCCQEAWILSGQQQVAKENQQVAKYVTLHQALLRLPQYQTDLLLTFNQPPPENRSSLGPENLSIPPWSLGDFEQLVTSLTLHDPNIFGPE", "length": 186, "header": "sp|Q32PE2-1|MOG1_BOVIN Isoform 1 of Ran guanine nucleotide release factor OS=Bos taurus OX=9913 GN=RANGRF PE=2 SV=1 CANONICAL=Q32PE2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512506", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512506", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of membrane depolarization during cardiac muscle cell action potential", "id": "GO:1900825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900825", "evidence": [ { "database": "UniProtKB", "id": "Q32PE2", "url": "https://www.uniprot.org/uniprotkb/Q32PE2" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q32PE2", "url": "https://www.uniprot.org/uniprotkb/Q32PE2" } ], "pmid": "" }, { "name": "heart contraction", "id": "GO:0060047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060047", "evidence": [ { "database": "UniProtKB", "id": "Q32PE2", "url": "https://www.uniprot.org/uniprotkb/Q32PE2" } ], "pmid": "" }, { "name": "regulation of sodium ion transmembrane transport", "id": "GO:1902305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902305", "evidence": [ { "database": "UniProtKB", "id": "Q32PE2", "url": "https://www.uniprot.org/uniprotkb/Q32PE2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32PE2", "url": "https://www.uniprot.org/uniprotkb/Q32PE2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q32PE2", "url": "https://www.uniprot.org/uniprotkb/Q32PE2" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "Q32PE2", "url": "https://www.uniprot.org/uniprotkb/Q32PE2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "sodium channel regulator activity", "id": "GO:0017080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017080", "evidence": [ { "database": "UniProtKB", "id": "Q32PE2", "url": "https://www.uniprot.org/uniprotkb/Q32PE2" } ], "pmid": "" }, { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "Q32PE2", "url": "https://www.uniprot.org/uniprotkb/Q32PE2" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "Q32PE2", "url": "https://www.uniprot.org/uniprotkb/Q32PE2" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "Q32PE2", "url": "https://www.uniprot.org/uniprotkb/Q32PE2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 149, "end_pos": 151, "annotation": "n_glycosylation_sequon" }, { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PE2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 186, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PE2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PE2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 149, "end_pos": 151 }, { "start_pos": 157, "end_pos": 159 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32PE3-1", "uniprot_ac": "Q32PE3", "uniprot_id": "SELK_BOVIN", "mass": { "chemical_mass": 10805.0, "monoisotopic_mass": 10805.0 }, "refseq": { "ac": "NP_001032566", "name": "selenoprotein K", "summary": "The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. A pseudogene of this locus has been identified on chromosome 5. [provided by RefSeq, Aug 2017].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032566" }, "gene_names": [ { "name": "SELENOK", "type": "recommended", "evidence": [ { "id": "Q32PE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PE3" } ] }, { "name": "SELENOK", "type": "synonym", "evidence": [ { "id": "NP_001032566", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032566" } ] }, { "name": "SELK", "type": "synonym", "evidence": [ { "id": "NP_001032566", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032566" } ] } ], "protein_names": [ { "name": "Selenoprotein K", "type": "recommended", "evidence": [ { "id": "Q32PE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PE3/entry#names_and_taxonomy" } ] }, { "name": "SelK", "type": "synonym", "evidence": [ { "id": "Q32PE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PE3/entry#names_and_taxonomy" } ] }, { "name": "selenoprotein K", "type": "synonym", "evidence": [ { "id": "NP_001032566", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032566" } ] } ], "function": [ { "annotation": "Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32PE3", "url": "https://www.uniprot.org/uniprotkb/Q32PE3#function" }, { "database": "UniProtKB", "id": "Q9Y6D0", "url": "https://www.uniprot.org/uniprotkb/Q9Y6D0#function" }, { "database": "UniProtKB", "id": "Q9JLJ1", "url": "https://www.uniprot.org/uniprotkb/Q9JLJ1#function" } ] }, { "annotation": "The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. A pseudogene of this locus has been identified on chromosome 5. [provided by RefSeq, Aug 2017].", "evidence": [ { "database": "RefSeq", "id": "NP_001032566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032566" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PE3", "url": "https://www.uniprot.org/uniprotkb/Q32PE3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SELENOK", "url": "https://www.uniprot.org/uniprotkb/Q32PE3", "locus": { "chromosome": "22", "start_pos": 47031659, "end_pos": 47028551, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032374", "url": "https://www.ensembl.org/id/ENSBTAG00000032374" } ] } } ], "crossref": [ { "id": "615114", "url": "https://www.ncbi.nlm.nih.gov/gene/615114", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR024491", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024491", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615114", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615114", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32PE3", "url": "https://www.orthodb.org/?gene=Q32PE3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16875", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16875", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16875:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16875:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10961", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10961", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032566", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32PE3", "url": "https://www.uniprot.org/uniprotkb/Q32PE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PE3-1", "url": "https://www.uniprot.org/uniprotkb/Q32PE3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVYISNGQVLDSRSQSPWRLSFITDFFWGIAEFVVLFFRTLLQQDVKKRRGYGSSSDSRYDDGRGPPGNPPRRRMGRINHLQGPNPPPMAGGUGR", "length": 95, "header": "sp|Q32PE3-1|SELK_BOVIN Isoform 1 of Selenoprotein K OS=Bos taurus OX=9913 GN=SELENOK PE=3 SV=3 CANONICAL=Q32PE3-1" }, "isoforms": [ { "isoform_ac": "Q32PE3-1", "url": "https://www.uniprot.org/uniprotkb/Q32PE3/entry#Q32PE3-1", "sequence": { "sequence": "MVYISNGQVLDSRSQSPWRLSFITDFFWGIAEFVVLFFRTLLQQDVKKRRGYGSSSDSRYDDGRGPPGNPPRRRMGRINHLQGPNPPPMAGGUGR", "length": 95, "header": "sp|Q32PE3-1|SELK_BOVIN Isoform 1 of Selenoprotein K OS=Bos taurus OX=9913 GN=SELENOK PE=3 SV=3 CANONICAL=Q32PE3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615114", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615114", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q32PE3", "url": "https://www.uniprot.org/uniprotkb/Q32PE3" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q32PE3", "url": "https://www.uniprot.org/uniprotkb/Q32PE3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q32PE3", "url": "https://www.uniprot.org/uniprotkb/Q32PE3" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q32PE3", "url": "https://www.uniprot.org/uniprotkb/Q32PE3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "calcium ion transport", "id": "GO:0006816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006816", "evidence": [ { "database": "UniProtKB", "id": "Q32PE3", "url": "https://www.uniprot.org/uniprotkb/Q32PE3" } ], "pmid": "" }, { "name": "endoplasmic reticulum calcium ion homeostasis", "id": "GO:0032469", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032469", "evidence": [ { "database": "UniProtKB", "id": "Q32PE3", "url": "https://www.uniprot.org/uniprotkb/Q32PE3" } ], "pmid": "" }, { "name": "protein palmitoylation", "id": "GO:0018345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018345", "evidence": [ { "database": "UniProtKB", "id": "Q32PE3", "url": "https://www.uniprot.org/uniprotkb/Q32PE3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32PF0-1", "uniprot_ac": "Q32PF0", "uniprot_id": "TM201_BOVIN", "mass": { "chemical_mass": 43243.0, "monoisotopic_mass": 43243.0 }, "refseq": { "ac": "NP_001032528", "name": "transmembrane protein 201", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032528" }, "gene_names": [ { "name": "TMEM201", "type": "recommended", "evidence": [ { "id": "Q32PF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF0" } ] }, { "name": "TMEM201", "type": "synonym", "evidence": [ { "id": "NP_001032528", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032528" } ] } ], "protein_names": [ { "name": "Transmembrane protein 201", "type": "recommended", "evidence": [ { "id": "Q32PF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF0/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 201", "type": "synonym", "evidence": [ { "id": "NP_001032528", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032528" } ] } ], "function": [ { "annotation": "Critical regulator of angiogenesis and endothelial cell (EC) migration. Promotes the migration of endothelial cells, which is essential for angiogenesis. Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope. This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development. Involved in nuclear movement during fibroblast polarization and migration. May recruit Ran GTPase to the nuclear periphery.", "evidence": [ { "database": "UniProtKB", "id": "Q32PF0", "url": "https://www.uniprot.org/uniprotkb/Q32PF0#function" }, { "database": "UniProtKB", "id": "Q5SNT2", "url": "https://www.uniprot.org/uniprotkb/Q5SNT2#function" }, { "database": "UniProtKB", "id": "A2A8U2", "url": "https://www.uniprot.org/uniprotkb/A2A8U2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PF0", "url": "https://www.uniprot.org/uniprotkb/Q32PF0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM201", "url": "https://www.uniprot.org/uniprotkb/Q32PF0", "locus": { "chromosome": "16", "start_pos": 43889228, "end_pos": 43911995, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003180", "url": "https://www.ensembl.org/id/ENSBTAG00000003180" } ] } } ], "crossref": [ { "id": "Q32PF0", "url": "https://alphafold.ebi.ac.uk/entry/Q32PF0", "database": "AlphaFoldDB", "categories": [] }, { "id": "507444", "url": "https://www.ncbi.nlm.nih.gov/gene/507444", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018617", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018617", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018861", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018861", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040041", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040041", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507444", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507444", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32PF0", "url": "https://www.orthodb.org/?gene=Q32PF0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28646", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28646", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28646:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28646:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09779", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09779", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10476", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10476", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032528", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32PF0", "url": "https://www.uniprot.org/uniprotkb/Q32PF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PF0-1", "url": "https://www.uniprot.org/uniprotkb/Q32PF0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGVSALLARCPTAGLAGGLGVTACAAAGVLLYRIARRMKPTHTVVNCWFCNQDTVVPYGNRNCWDCPHCEQYNGFQENGDYNKPIPAQYLEHLNHVVSGSPGPRAPAQPLQWVSSQVLLCRRCSHHQTAKVKQLAAFSPRDEGRYDEEIEVYRHHLEQMYKLCRPCQAAVEHYIKHQNRQLRALLLSHQFKRREADQTHTQSFCASAVKAPAQVIVLRALAFLACAFLLTTALYGTSNPFAPGAPLPPTLPTGSNGSAPPDNGTATGAEGWRQLLGLLPEHAAEKLREAWAFGQSHQMGVVALGLLTCLLAMLLAGRIRLRRIDAFSTGLWALLLGLHLAEQYLQAASPSWLDTLKFSTTSLCCLVGFTAAVATRKATGPRRFRPRRSEKQQ", "length": 393, "header": "sp|Q32PF0-1|TM201_BOVIN Isoform 1 of Transmembrane protein 201 OS=Bos taurus OX=9913 GN=TMEM201 PE=2 SV=1 CANONICAL=Q32PF0-1" }, "isoforms": [ { "isoform_ac": "Q32PF0-1", "url": "https://www.uniprot.org/uniprotkb/Q32PF0/entry#Q32PF0-1", "sequence": { "sequence": "MEGVSALLARCPTAGLAGGLGVTACAAAGVLLYRIARRMKPTHTVVNCWFCNQDTVVPYGNRNCWDCPHCEQYNGFQENGDYNKPIPAQYLEHLNHVVSGSPGPRAPAQPLQWVSSQVLLCRRCSHHQTAKVKQLAAFSPRDEGRYDEEIEVYRHHLEQMYKLCRPCQAAVEHYIKHQNRQLRALLLSHQFKRREADQTHTQSFCASAVKAPAQVIVLRALAFLACAFLLTTALYGTSNPFAPGAPLPPTLPTGSNGSAPPDNGTATGAEGWRQLLGLLPEHAAEKLREAWAFGQSHQMGVVALGLLTCLLAMLLAGRIRLRRIDAFSTGLWALLLGLHLAEQYLQAASPSWLDTLKFSTTSLCCLVGFTAAVATRKATGPRRFRPRRSEKQQ", "length": 393, "header": "sp|Q32PF0-1|TM201_BOVIN Isoform 1 of Transmembrane protein 201 OS=Bos taurus OX=9913 GN=TMEM201 PE=2 SV=1 CANONICAL=Q32PF0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 256, "start_aa": "Asn", "end_pos": 256, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn256", "evidence": [ { "id": "Q32PF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF0#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 263, "start_aa": "Asn", "end_pos": 263, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn263", "evidence": [ { "id": "Q32PF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF0#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:507444", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507444", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "Q32PF0", "url": "https://www.uniprot.org/uniprotkb/Q32PF0" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "Q32PF0", "url": "https://www.uniprot.org/uniprotkb/Q32PF0" } ], "pmid": "" }, { "name": "nuclear inner membrane", "id": "GO:0005637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005637", "evidence": [ { "database": "UniProtKB", "id": "Q32PF0", "url": "https://www.uniprot.org/uniprotkb/Q32PF0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "Q32PF0", "url": "https://www.uniprot.org/uniprotkb/Q32PF0" } ], "pmid": "" }, { "name": "positive regulation of endothelial cell migration", "id": "GO:0010595", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010595", "evidence": [ { "database": "UniProtKB", "id": "Q32PF0", "url": "https://www.uniprot.org/uniprotkb/Q32PF0" } ], "pmid": "" }, { "name": "nuclear migration along microtubule", "id": "GO:0030473", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030473", "evidence": [ { "database": "UniProtKB", "id": "Q32PF0", "url": "https://www.uniprot.org/uniprotkb/Q32PF0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "Q32PF0", "url": "https://www.uniprot.org/uniprotkb/Q32PF0" } ], "pmid": "" }, { "name": "lamin binding", "id": "GO:0005521", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005521", "evidence": [ { "database": "UniProtKB", "id": "Q32PF0", "url": "https://www.uniprot.org/uniprotkb/Q32PF0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" }, { "start_pos": 263, "end_pos": 265, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PF0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 393, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PF0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PF0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 256, 263 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 256, "end_pos": 258 }, { "start_pos": 263, "end_pos": 265 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32PF6-1", "uniprot_ac": "Q32PF6", "uniprot_id": "DBP_BOVIN", "mass": { "chemical_mass": 34322.0, "monoisotopic_mass": 34322.0 }, "refseq": { "ac": "NP_001032522", "name": "D site-binding protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032522" }, "gene_names": [ { "name": "DBP", "type": "recommended", "evidence": [ { "id": "Q32PF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF6" } ] }, { "name": "DBP", "type": "synonym", "evidence": [ { "id": "NP_001032522", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032522" } ] } ], "protein_names": [ { "name": "D site-binding protein", "type": "recommended", "evidence": [ { "id": "Q32PF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF6/entry#names_and_taxonomy" } ] }, { "name": "Albumin D box-binding protein", "type": "synonym", "evidence": [ { "id": "Q32PF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF6/entry#names_and_taxonomy" } ] }, { "name": "Albumin D-element-binding protein", "type": "synonym", "evidence": [ { "id": "Q32PF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF6/entry#names_and_taxonomy" } ] }, { "name": "D site-binding protein", "type": "synonym", "evidence": [ { "id": "NP_001032522", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032522" } ] }, { "name": "albumin D box-binding protein", "type": "synonym", "evidence": [ { "id": "NP_001032522", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032522" } ] }, { "name": "albumin D-element binding protein", "type": "synonym", "evidence": [ { "id": "NP_001032522", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032522" } ] } ], "function": [ { "annotation": "This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32PF6", "url": "https://www.uniprot.org/uniprotkb/Q32PF6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PF6", "url": "https://www.uniprot.org/uniprotkb/Q32PF6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DBP", "url": "https://www.uniprot.org/uniprotkb/Q32PF6", "locus": { "chromosome": "18", "start_pos": 55272313, "end_pos": 55278976, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006754", "url": "https://www.ensembl.org/id/ENSBTAG00000006754" } ] } } ], "crossref": [ { "id": "Q32PF6", "url": "https://alphafold.ebi.ac.uk/entry/Q32PF6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006754", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006754", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14695", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14695", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "503577", "url": "https://www.ncbi.nlm.nih.gov/gene/503577", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040223", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040223", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:503577", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:503577", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EYEHPSS", "url": "https://omabrowser.org/oma/group/EYEHPSS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32PF6", "url": "https://www.orthodb.org/?gene=Q32PF6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11988", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11988", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11988:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11988:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07716", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07716", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032522", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032522", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32PF6", "url": "https://www.uniprot.org/uniprotkb/Q32PF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PF6-1", "url": "https://www.uniprot.org/uniprotkb/Q32PF6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARPVSERTPAPLLLGGPTGAPPGGGALLGLRSLLQGTSKPKEPTSCLLKEKERKASPPAATVPGPGLETAGPADASAGAVVGGGSPRGRPGAAPGPGLLAPLLWERTLPFGDVEYVDLDAFLLEHGLPPSPPPPGGPSPAPSPVRTPAPSPRPGSCGSASPRSSPGHAPARAALGAAGGHRAGLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSIPGHETFDPRRHRFSEEELKPQPIMKKARKIQVPEEQKDEKYWSRRYKNNEAAKRSRDARRLKENQISVRAAFLEKENALLRQEVVAVRQELSHYRAVLSRYQAQHGAL", "length": 325, "header": "sp|Q32PF6-1|DBP_BOVIN Isoform 1 of D site-binding protein OS=Bos taurus OX=9913 GN=DBP PE=2 SV=2 CANONICAL=Q32PF6-1" }, "isoforms": [ { "isoform_ac": "Q32PF6-1", "url": "https://www.uniprot.org/uniprotkb/Q32PF6/entry#Q32PF6-1", "sequence": { "sequence": "MARPVSERTPAPLLLGGPTGAPPGGGALLGLRSLLQGTSKPKEPTSCLLKEKERKASPPAATVPGPGLETAGPADASAGAVVGGGSPRGRPGAAPGPGLLAPLLWERTLPFGDVEYVDLDAFLLEHGLPPSPPPPGGPSPAPSPVRTPAPSPRPGSCGSASPRSSPGHAPARAALGAAGGHRAGLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSIPGHETFDPRRHRFSEEELKPQPIMKKARKIQVPEEQKDEKYWSRRYKNNEAAKRSRDARRLKENQISVRAAFLEKENALLRQEVVAVRQELSHYRAVLSRYQAQHGAL", "length": 325, "header": "sp|Q32PF6-1|DBP_BOVIN Isoform 1 of D site-binding protein OS=Bos taurus OX=9913 GN=DBP PE=2 SV=2 CANONICAL=Q32PF6-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 19, "start_aa": "Thr", "end_pos": 19, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr19", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 86, "end_pos": 86, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PF6", "url": "https://www.uniprot.org/uniprotkb/Q32PF6" } ], "site_lbl": "Ser86" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:503577", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:503577", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RIP8-1", "protein_name": "D-box binding PAR bZIP transcription factor", "gene_name": "DBP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARPVSDRTPAPLLLGGPAGAPPGGGALLGLRSLLQGTSKPKEPTSCLLKEKERKAAPPAATVPGPGLEPAGPADASAGAVVGGGSPRGRPGAVPGPGLLAPLLWERTLPFGDVEYVDLDAFLLEHGLPPSPPPPGGPSPAPSPVRTPAPSPGPGSCGSASPRSSPGHAPARAALGAAGGHRAGLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSIPGHETFDPRRHRFSEEELKPQPIMKKARKIQVPEEQKDEKYWSRRYKNNEAAKRSRDARRLKENQISVRAAFLEKENALLRQEVVAVRQELSHYRAVLSRYQAQHGAL", "length": 325 }, "evidence": [ { "id": "Q32PF6", "url": "https://omabrowser.org/oma/group/Q32PF6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P16443-1", "protein_name": "D site-binding protein", "gene_name": "Dbp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARPLSDRTPGPLLLGGPAGAPPGGGALLGLRSLLQGNSKPKEPASCLLKEKERKATLPSAPVPGPVLETAGPADAPTGAVSGGGSPRGRSGPVAGPSLFAPLLWERTLPFGDVEYVDLDAFLLEHGLPPSPPPPGGLSPAPSPARTPAPSPGPGSCSSSSPRSSPGHAPARATLGAAGGHRAGLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSIPGHETFDPRRHRFSEEELKPQPIMKKARKVQVPEEQKDEKYWSRRYKNNEAAKRSRDARRLKENQISVRAAFLEKENALLRQEVVAVRQELSHYRAVLSRYQAQHGTL", "length": 325 }, "evidence": [ { "id": "Q32PF6", "url": "https://omabrowser.org/oma/group/Q32PF6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q10586-1", "protein_name": "D site-binding protein", "gene_name": "DBP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARPVSDRTPAPLLLGGPAGTPPGGGALLGLRSLLQGTSKPKEPASCLLKEKERKAALPAATTPGPGLETAGPADAPAGAVVGGGSPRGRPGPVPAPGLLAPLLWERTLPFGDVEYVDLDAFLLEHGLPPSPPPPGGPSPEPSPARTPAPSPGPGSCGSASPRSSPGHAPARAALGTASGHRAGLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSIPGHETFDPRRHRFSEEELKPQPIMKKARKIQVPEEQKDEKYWSRRYKNNEAAKRSRDARRLKENQISVRAAFLEKENALLRQEVVAVRQELSHYRAVLSRYQAQHGAL", "length": 325 }, "evidence": [ { "id": "Q32PF6", "url": "https://omabrowser.org/oma/group/Q32PF6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q60925-1", "protein_name": "D site-binding protein", "gene_name": "Dbp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARPLSDRTPGPLLLGGPAGAPPGGGALLGLRSLLQGNSKPKEPASCLLKEKERKATLPSAPVPGPGLETAGPADAPSGAVSGGGSPRGRSGPVAGPSLFAPLLWERTLPFGDVEYVDLDAFLLEHGLPPSPPPPGGLSPAPSPARTPAPSPGPGSCSSSSPRSSPGHAPARATLGAAGGHRAGLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSIPGHETFDPRRHRFSEEELKPQPIMKKARKVQVPEEQKDEKYWSRRYKNNEAAKRSRDARRLKENQISVRAAFLEKENALLRQEVVAVRQELSHYRAVLSRYQAQHGTL", "length": 325 }, "evidence": [ { "id": "Q32PF6", "url": "https://omabrowser.org/oma/group/Q32PF6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32PF6", "url": "https://www.uniprot.org/uniprotkb/Q32PF6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q32PF6", "url": "https://www.uniprot.org/uniprotkb/Q32PF6" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "Q32PF6", "url": "https://www.uniprot.org/uniprotkb/Q32PF6" } ], "pmid": "" }, { "name": "rhythmic process", "id": "GO:0048511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048511", "evidence": [ { "database": "UniProtKB", "id": "Q32PF6", "url": "https://www.uniprot.org/uniprotkb/Q32PF6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q32PF6", "url": "https://www.uniprot.org/uniprotkb/Q32PF6" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q32PF6", "url": "https://www.uniprot.org/uniprotkb/Q32PF6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PF6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 325, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PF6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PF6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32PF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF6" }, { "id": "PRU00978", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00978" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "bZIP", "eco_id": "ECO_0000255", "start_pos": 255, "end_pos": 318, "start_aa": "Asp", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 19 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 86 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", 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{ "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": 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"residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32PG3-1", "uniprot_ac": "Q32PG3", "uniprot_id": "WDR48_BOVIN", "mass": { "chemical_mass": 76192.0, "monoisotopic_mass": 76192.0 }, "refseq": { "ac": "NP_001069992", "name": "WD repeat-containing protein 48", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069992" }, "gene_names": [ { "name": "WDR48", "type": "recommended", "evidence": [ { "id": "Q32PG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PG3" } ] }, { "name": "UAF1", "type": "synonym", "evidence": [ { "id": "Q32PG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PG3" } ] }, { "name": "WDR48", "type": "synonym", "evidence": [ { "id": "NP_001069992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069992" } ] } ], "protein_names": [ { "name": "WD repeat-containing protein 48", "type": "recommended", "evidence": [ { "id": "Q32PG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PG3/entry#names_and_taxonomy" } ] }, { "name": "USP1-associated factor 1", "type": "synonym", "evidence": [ { "id": "NP_001069992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069992" }, { "id": "Q32PG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PG3/entry#names_and_taxonomy" } ] }, { "name": "WD repeat-containing protein 48", "type": "synonym", "evidence": [ { "id": "NP_001069992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069992" } ] } ], "function": [ { "annotation": "Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. Also activates deubiquitinating activity of complexes containing USP12. Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme. Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination. Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes. Together with ATAD5 and by regulating USP1 activity, has a role in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Together with ATAD5, has a role in recruiting RAD51 to stalled forks during replication stress.", "evidence": [ { "database": "UniProtKB", "id": "Q32PG3", "url": "https://www.uniprot.org/uniprotkb/Q32PG3#function" }, { "database": "UniProtKB", "id": "Q8TAF3", "url": "https://www.uniprot.org/uniprotkb/Q8TAF3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PG3", "url": "https://www.uniprot.org/uniprotkb/Q32PG3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR48", "url": "https://www.uniprot.org/uniprotkb/Q32PG3", "locus": { "chromosome": "22", "start_pos": 12429953, "end_pos": 12377039, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003745", "url": "https://www.ensembl.org/id/ENSBTAG00000003745" } ] } } ], "crossref": [ { "id": "Q32PG3", "url": "https://alphafold.ebi.ac.uk/entry/Q32PG3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17041", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17041", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "618860", "url": "https://www.ncbi.nlm.nih.gov/gene/618860", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051246", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051246", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618860", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618860", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32PG3", "url": "https://www.orthodb.org/?gene=Q32PG3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19862", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19862", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19862:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19862:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11816", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11816", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069992", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32PG3", "url": "https://www.uniprot.org/uniprotkb/Q32PG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PG3-1", "url": "https://www.uniprot.org/uniprotkb/Q32PG3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQCHILNDKRHLLTKDTNNNVAYWDVLKACKVEDLGKVDFEDEIKKRFKMVYVPNWFSVDLKTGMLTITLDESDCFAAWVSAKDAGFSSPDGSDPKLNLGGLLLQALLEYWPRTHVNPIDEEENEVNHVNGEQENRVQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGETESMLLNETVPQWVIDITVDKNMPKFNKIPFYLQPHASSGAKTLKKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPGEQEKEEDIAVLAEEKIELLCQDQVLDPNMDLRTVKHFIWKSGGDLTLHYRQKST", "length": 677, "header": "sp|Q32PG3-1|WDR48_BOVIN Isoform 1 of WD repeat-containing protein 48 OS=Bos taurus OX=9913 GN=WDR48 PE=2 SV=1 CANONICAL=Q32PG3-1" }, "isoforms": [ { "isoform_ac": "Q32PG3-1", "url": "https://www.uniprot.org/uniprotkb/Q32PG3/entry#Q32PG3-1", "sequence": { "sequence": "MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQCHILNDKRHLLTKDTNNNVAYWDVLKACKVEDLGKVDFEDEIKKRFKMVYVPNWFSVDLKTGMLTITLDESDCFAAWVSAKDAGFSSPDGSDPKLNLGGLLLQALLEYWPRTHVNPIDEEENEVNHVNGEQENRVQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGETESMLLNETVPQWVIDITVDKNMPKFNKIPFYLQPHASSGAKTLKKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPGEQEKEEDIAVLAEEKIELLCQDQVLDPNMDLRTVKHFIWKSGGDLTLHYRQKST", "length": 677, "header": "sp|Q32PG3-1|WDR48_BOVIN Isoform 1 of WD repeat-containing protein 48 OS=Bos taurus OX=9913 GN=WDR48 PE=2 SV=1 CANONICAL=Q32PG3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 28, "end_pos": 28, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q32PG3", "url": "https://www.uniprot.org/uniprotkb/Q32PG3" } ], "site_lbl": "Tyr28" }, { "start_pos": 613, "end_pos": 613, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q32PG3", "url": "https://www.uniprot.org/uniprotkb/Q32PG3" } ], "site_lbl": "Thr613" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618860", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618860", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q32PG3", "url": "https://www.uniprot.org/uniprotkb/Q32PG3" } ], "pmid": "" }, { "name": "double-stranded DNA binding", "id": "GO:0003690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690", "evidence": [ { "database": "UniProtKB", "id": "Q32PG3", "url": "https://www.uniprot.org/uniprotkb/Q32PG3" } ], "pmid": "" }, { "name": "ubiquitin binding", "id": "GO:0043130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130", "evidence": [ { "database": "UniProtKB", "id": "Q32PG3", "url": "https://www.uniprot.org/uniprotkb/Q32PG3" } ], "pmid": "" }, { "name": "single-stranded DNA binding", "id": "GO:0003697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003697", "evidence": [ { "database": "UniProtKB", "id": "Q32PG3", "url": "https://www.uniprot.org/uniprotkb/Q32PG3" } ], "pmid": "" }, { "name": "deubiquitinase activator activity", "id": "GO:0035800", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035800", "evidence": [ { "database": "UniProtKB", "id": "Q32PG3", "url": "https://www.uniprot.org/uniprotkb/Q32PG3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q32PG3", "url": "https://www.uniprot.org/uniprotkb/Q32PG3" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "Q32PG3", "url": "https://www.uniprot.org/uniprotkb/Q32PG3" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "Q32PG3", "url": "https://www.uniprot.org/uniprotkb/Q32PG3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "Q32PG3", "url": "https://www.uniprot.org/uniprotkb/Q32PG3" } ], "pmid": "" }, { "name": "double-strand break repair via homologous recombination", "id": "GO:0000724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000724", "evidence": [ { "database": "UniProtKB", "id": "Q32PG3", "url": "https://www.uniprot.org/uniprotkb/Q32PG3" } ], "pmid": "" }, { "name": "positive regulation of double-strand break repair via homologous recombination", "id": "GO:1905168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905168", "evidence": [ { "database": "UniProtKB", "id": "Q32PG3", "url": "https://www.uniprot.org/uniprotkb/Q32PG3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 543, "end_pos": 545, "annotation": "n_glycosylation_sequon" }, { "start_pos": 609, "end_pos": 611, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": 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"field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q32PH8-1", "uniprot_ac": "Q32PH8", "uniprot_id": "EF1A2_BOVIN", "mass": { "chemical_mass": 50470.0, "monoisotopic_mass": 50470.0 }, "refseq": { "ac": "NP_001032541", "name": "elongation factor 1-alpha 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032541" }, "gene_names": [ { "name": "EEF1A2", "type": "recommended", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ] }, { "name": "EEF1A2", "type": "synonym", "evidence": [ { "id": "NP_001032541", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032541" } ] } ], "protein_names": [ { "name": "Elongation factor 1-alpha 2", "type": "recommended", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8/entry#names_and_taxonomy" } ] }, { "name": "3.6.5.-", "type": "synonym", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8/entry#names_and_taxonomy" } ] }, { "name": "EF-1-alpha-2", "type": "synonym", "evidence": [ { "id": "NP_001032541", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032541" }, { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8/entry#names_and_taxonomy" } ] }, { "name": "Eukaryotic elongation factor 1 A-2", "type": "synonym", "evidence": [ { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8/entry#names_and_taxonomy" } ] }, { "name": "eEF1A-2", "type": "synonym", "evidence": [ { "id": "NP_001032541", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032541" }, { "id": "Q32PH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PH8/entry#names_and_taxonomy" } ] }, { "name": "elongation factor 1 A-2", "type": "synonym", "evidence": [ { "id": "NP_001032541", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032541" } ] }, { "name": "elongation factor 1-alpha 2", "type": "synonym", "evidence": [ { "id": "NP_001032541", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032541" } ] }, { "name": "eukaryotic elongation factor 1 A-2", "type": "synonym", "evidence": [ { "id": "NP_001032541", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032541" } ] } ], "function": [ { "annotation": "Identification of loci associated with susceptibility to bovine paratuberculosis and with the dysregulation of the MECOM, eEF1A2, and U1 spliceosomal RNA expression. Erratum:[Sci Rep. 2021 Oct 25;11(1):21337. doi: 10.1038/s41598-021-00840-3. PMID: 34697373] Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001032541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032541" }, { "database": "PubMed", "id": "33432064", "url": "https://glygen.org/publication/PubMed/33432064" } ] }, { "annotation": "Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32PH8", "url": "https://www.uniprot.org/uniprotkb/Q32PH8#function" }, { "database": "UniProtKB", "id": "P68104", "url": "https://www.uniprot.org/uniprotkb/P68104#function" }, { "database": "UniProtKB", "id": "Q71V39", "url": "https://www.uniprot.org/uniprotkb/Q71V39#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PH8", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EEF1A2", "url": "https://www.uniprot.org/uniprotkb/Q32PH8", "locus": { "chromosome": "13", "start_pos": 54159693, "end_pos": 54152019, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021685", "url": "https://www.ensembl.org/id/ENSBTAG00000021685" } ] } } ], "crossref": [ { "id": "Q32PH8", "url": "https://alphafold.ebi.ac.uk/entry/Q32PH8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021685", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021685", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01883", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01883", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03693", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03693", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03705", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03705", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515233", "url": "https://www.ncbi.nlm.nih.gov/gene/515233", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004539", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004539", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050100", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050100", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054696", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054696", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515233", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515233", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EMHHKSV", "url": "https://omabrowser.org/oma/group/EMHHKSV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32PH8", "url": "https://www.orthodb.org/?gene=Q32PH8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23115", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23115", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00009", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00009", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03144", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03144", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22594", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22594", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032541", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32PH8", "url": "https://www.uniprot.org/uniprotkb/Q32PH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PH8-1", "url": "https://www.uniprot.org/uniprotkb/Q32PH8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNVCGDSKSDPPQEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSGDAAIVEMVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVGVIKNVEKKSGGAGKVTKSAQKAQKAGK", "length": 463, "header": "sp|Q32PH8-1|EF1A2_BOVIN Isoform 1 of Elongation factor 1-alpha 2 OS=Bos taurus OX=9913 GN=EEF1A2 PE=2 SV=1 CANONICAL=Q32PH8-1" }, "isoforms": [ { "isoform_ac": "Q32PH8-1", "url": "https://www.uniprot.org/uniprotkb/Q32PH8/entry#Q32PH8-1", "sequence": { "sequence": "MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNVCGDSKSDPPQEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSGDAAIVEMVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVGVIKNVEKKSGGAGKVTKSAQKAQKAGK", "length": 463, "header": "sp|Q32PH8-1|EF1A2_BOVIN Isoform 1 of Elongation factor 1-alpha 2 OS=Bos taurus OX=9913 GN=EEF1A2 PE=2 SV=1 CANONICAL=Q32PH8-1" }, "locus": { "chromosome": "13", "start_pos": 54159413, "end_pos": 54153425, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028899.5", "url": "https://www.ensembl.org/id/ENSBTAT00000028899.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028899.3", "url": "https://www.ensembl.org/id/ENSBTAP00000028899.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 163, "end_pos": 163, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PH8", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ], "site_lbl": "Ser163" }, { "start_pos": 224, "end_pos": 224, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PH8", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ], "site_lbl": "Ser224" }, { "start_pos": 239, "end_pos": 239, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q32PH8", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ], "site_lbl": "Thr239" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Identification of loci associated with susceptibility to bovine paratuberculosis and with the dysregulation of the MECOM, eEF1A2, and U1 spliceosomal RNA expression.", "journal": "Scientific reports", "date": "2021-01-11", "authors": "Canive Maria, Fernandez-Jimenez Nora, Casais Rosa, V\u00e1zquez Patricia, Lav\u00edn Jos\u00e9 Luis, Bilbao Jos\u00e9 Ram\u00f3n, Blanco-V\u00e1zquez Cristina, Garrido Joseba M, Juste Ram\u00f3n A, Alonso-Hearn Marta", "evidence": [ { "database": "RefSeq", "id": "NP_001032541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032541" } ], "reference": [ { "type": "PubMed", "id": "33432064", "url": "https://glygen.org/publication/PubMed/33432064" } ] } ], "pathway": [ { "id": "bta:515233", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515233", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1N9H4-1", "protein_name": "Elongation factor 1-alpha", "gene_name": "EEF1A2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGINKMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNVCGDSKSDPPQEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSGDAAIVEMIPGKPMCVESFSQYPPLGRFAVRDMRQTVAVGVIKNVEKKSGGAGKVTKSAQKAQKAGK", "length": 463 }, "evidence": [ { "id": "Q32PH8", "url": "https://omabrowser.org/oma/group/Q32PH8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O88943-1", "protein_name": "Potassium voltage-gated channel subfamily KQT member 2", "gene_name": "Kcnq2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMISSQTQTYGASRLIPPLNQLEMLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRKYAAPPVMPPAECPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLNALASCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK", "length": 852 }, "evidence": [ { "id": "Q32PH8", "url": "https://omabrowser.org/oma/group/Q32PH8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P62631-1", "protein_name": "Elongation factor 1-alpha 2", "gene_name": "Eef1a2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNVCGDSKADPPQEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSGDAAIVEMVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVGVIKNVEKKSGGAGKVTKSAQKAQKAGK", "length": 463 }, "evidence": [ { "id": "Q32PH8", "url": "https://omabrowser.org/oma/group/Q32PH8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P62632-1", "protein_name": "Elongation factor 1-alpha 2", "gene_name": "Eef1a2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNVCGDSKADPPQEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSGDAAIVEMVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVGVIKNVEKKSGGAGKVTKSAQKAQKAGK", "length": 463 }, "evidence": [ { "id": "Q32PH8", "url": "https://omabrowser.org/oma/group/Q32PH8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "Q32PH8", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q32PH8", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "Q32PH8", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q32PH8", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ], "pmid": "" }, { "name": "translation elongation factor activity", "id": "GO:0003746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003746", "evidence": [ { "database": "UniProtKB", "id": "Q32PH8", "url": "https://www.uniprot.org/uniprotkb/Q32PH8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, 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[ "Protein" ] }, { "id": "Q32PI6-1", "url": "https://www.uniprot.org/uniprotkb/Q32PI6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQQLVRAGARAWLRPRGCRGLSALTEEAVQSAEKPEPLANAGPQAPVLRRCELPVPLHRRPVQAWVESLRGYEQERVGLTELHPDVFSTAPRLDILHQVAIWQKNFKRISYAKTKTRAEVRGGGRKPWQQKGSGRARHGSIRSPIWRGGGVAHGPRGPTSYYYMLPMKVRVQGLKVALTVKLAQDDLHIVDSLELPTTDPQYLMELARYRRWGDSVLFVDLEHEDMPQNVVAATSGLKTFNLIPAIGLNVHSMLKHQTLVLTLPTVAFLEEKLLWHDSRYTPLYPFRLPYRDFP", "length": 294, "header": "sp|Q32PI6-1|RM04_BOVIN Isoform 1 of Large ribosomal subunit protein uL4m OS=Bos taurus OX=9913 GN=MRPL4 PE=1 SV=1 CANONICAL=Q32PI6-1" }, "isoforms": [ { "isoform_ac": "Q32PI6-1", "url": "https://www.uniprot.org/uniprotkb/Q32PI6/entry#Q32PI6-1", "sequence": { "sequence": 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mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Suzuki T, Terasaki M, Takemoto-Hori C, Hanada T, Ueda T, Wada A, Watanabe K", "evidence": [ { "database": "UniProtKB", "id": "Q32PI6", "url": "https://www.uniprot.org/uniprotkb/Q32PI6" } ], "reference": [ { "type": "PubMed", "id": "11279069", "url": "https://glygen.org/publication/PubMed/11279069" } ] }, { "title": "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Koc E C, Burkhart W, Blackburn K, Moyer M B, Schlatzer D M, Moseley A, Spremulli L L", "evidence": [ { "database": "UniProtKB", "id": "Q32PI6", "url": "https://www.uniprot.org/uniprotkb/Q32PI6" } ], "reference": [ { "type": "PubMed", "id": "11551941", "url": "https://glygen.org/publication/PubMed/11551941" } ] }, { "title": "A structural model for the large subunit of the mammalian mitochondrial ribosome.", "journal": "J. Mol. Biol.", "date": "2006", "authors": "Mears Jason A, Sharma Manjuli R, Gutell Robin R, McCook Amanda S, Richardson Paul E, Caulfield Thomas R, Agrawal Rajendra K, Harvey Stephen C", "evidence": [ { "database": "UniProtKB", "id": "Q32PI6", "url": "https://www.uniprot.org/uniprotkb/Q32PI6" } ], "reference": [ { "type": "PubMed", "id": "16510155", "url": "https://glygen.org/publication/PubMed/16510155" } ] } ], "pathway": [ { "id": "bta:507154", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507154", "resource": "KEGG Pathway" }, { "id": "R-BTA-5389840", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-9937383", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "resource": "Reactome", "description": "Mitochondrial ribosome-associated quality control" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A131-1", "protein_name": "Large ribosomal subunit protein uL4m", "gene_name": "Mrpl4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLRLFQAASRAWLRPNGSRVISSLAEDAVRPAEISEPGDSAGLLDPVLRKCELPIPAPRRPVQAWVESLRGFEQERIGLAELHPDVFATTPRLDILHQVAVWQRNFKRISYAKTKTRAEVSGGGRKPWQQKGSGRARHGSIRSPIWRGGGVAHGPRGPTSYYYMLPMKVRALGLKVALTVKLMQDDLHIVDSLELPTADPQYLTELAQYRHWGSSVLLVDLTHEEMPKNVMAATSRLNSFNLIPAVGLNVYSMLKHQTLVLTLPSVAFLEDKLLWQDSRYTPLYPFRLPYSDFP", "length": 294 }, "evidence": [ { "id": "Q32PI6", "url": "https://omabrowser.org/oma/group/Q32PI6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H6D5-1", "protein_name": "Large ribosomal subunit protein uL4m", "gene_name": "Mrpl4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLRLFRAASQAWVRPPGSRVLSSLAEGAARPAESSQPGATAGLLDPVVRKCELRIPAHRRPVHAWVESLRGFEQERVGLAELHPDVFATAPRLDILHQVATWQKNFKRISYAKTKTRAEVSGGGRKPWQQKGSGRARHGSIRSPLWRGGGVAHGPRGPTSYYYMLPMKVRALGLKAALTVKLMQDDLHIVDSLELPTADPQYLTELAQYRHWGSSVLLVDLTHEEAPKNVVAATSRLKSFNLIPAVGLNVYSMLKHQTLVLTLPSIAFLEDKLLWQDSRYTPLYPFRFPYNDFP", "length": 294 }, "evidence": [ { "id": "Q32PI6", "url": "https://omabrowser.org/oma/group/Q32PI6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q503X2-1", "protein_name": "Large ribosomal subunit protein uL4m", "gene_name": "mrpl4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFRATLAICGRTVVKRQFISSVSGESALPPNLRLPPNLIGVAAEKRPPPSGSDLPVVRRCEADVPAHLTPAQTWLESLGSRDSDQLGVVDLHPDVFSVPIRLDILHAVEVWQRNFKRISYANVKTRAEVRGGGRKPWQQKRTGRARHGSIRSPLWRGGGIIHGPRGPTSYYYMLPMKVRVQGLKIALSAKLAQDYLHIVDSLEIPTPDPQYLQDLVKHRQWGDSVLIVDVGEEFPQNILKATEDLKTVNIIPALGLNVHSLLKHESLVLTLEAVKFLEKKLLWHDVRYTPLYPFKLPYSDLP", "length": 302 }, "evidence": [ { "id": "Q32PI6", "url": "https://omabrowser.org/oma/group/Q32PI6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9BYD3-1", "protein_name": "Large ribosomal subunit protein uL4m", "gene_name": "MRPL4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLQFVRAGARAWLRPTGSQGLSSLAEEAARATENPEQVASEGLPEPVLRKVELPVPTHRRPVQAWVESLRGFEQERVGLADLHPDVFATAPRLDILHQVAMWQKNFKRISYAKTKTRAEVRGGGRKPWPQKGTGRARHGSIRSPLWRGGGVAHGPRGPTSYYYMLPMKVRALGLKVALTVKLAQDDLHIMDSLELPTGDPQYLTELAHYRRWGDSVLLVDLTHEEMPQSIVEATSRLKTFNLIPAVGLNVHSMLKHQTLVLTLPTVAFLEDKLLWQDSRYRPLYPFSLPYSDFPRPLPHATQGPAATPYHC", "length": 311 }, "evidence": [ { "id": "Q32PI6", "url": "https://omabrowser.org/oma/group/Q32PI6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DCU6-1", "protein_name": "Large ribosomal subunit protein uL4m", "gene_name": "Mrpl4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRLFQAASRASLRLSGSRVIHSLAEGAERPAEISEPRDSAGLLDPVLRKCELRIPVHRRPVQAWVESLRGFEQERIGLAELHPDVFATAPRLDIVHQVAIWQRNFRRISYANTKTRAEVSGGGRKPWQQKGSGRARHGSIRSPLWRGGGVAHGPRGPTSYYYMLPMKVRALGLKVALTVKLMQDDLHIVDSLELPTADPQYLTELAQYRHWGSSVLLVDLTHEEMPKNVVAATSGLNSFNLIPAVGLNVYSMLKHQTLVLTLPSVAFLEDKLLWQDSRYTPLYPFRLPYSDFP", "length": 294 }, "evidence": [ { "id": "Q32PI6", "url": "https://omabrowser.org/oma/group/Q32PI6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9V3D0-1", "protein_name": "Large ribosomal subunit protein uL4m", "gene_name": "mRpL4", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLNNILKTSRQVLYPVARTFSRSGNHGNVVTEAAATVGAPPATRSPLILPQDYTDCLPVSRNTARQAWIENTDAVAERKVGLIELHPDVFAAQPRVDIIQENVEWQSKYRYVSMAHTKTRAEVRGGGRKPWPQKGGGRARHGSLRSPMLKGGGVVHGPRSPTTHFYMLPFYKRVLGLTSTLSVKLAQDDLHIIDNVDIPTGDAEFLKDLIAERNWGPSVLIVDEDHMFPANICQASDDLGYVNLMPTFGLNVYSMLKHDTLVLTVAAVKHLEQRLLYQLNRNDAASKGGKFKLDQV", "length": 296 }, "evidence": [ { "id": "Q32PI6", "url": "https://omabrowser.org/oma/group/Q32PI6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "Q32PI6", "url": "https://www.uniprot.org/uniprotkb/Q32PI6" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q32PI6", "url": "https://www.uniprot.org/uniprotkb/Q32PI6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q32PI6", "url": "https://www.uniprot.org/uniprotkb/Q32PI6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q32PI6", "url": "https://www.uniprot.org/uniprotkb/Q32PI6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PI6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 294, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PI6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PI6" }, { "pdb_id": "2ftc", "pdb_chain": "d", "start_pos": 97, "end_pos": 270, "overlap": "1.0", "method": "Electron_Microscopy", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/2ftc.pdb", "url_external": "https://www.rcsb.org/structure/2ftc" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q32PJ3-1", "uniprot_ac": "Q32PJ3", "uniprot_id": "ORC3_BOVIN", "mass": { "chemical_mass": 82231.0, "monoisotopic_mass": 82231.0 }, "refseq": { "ac": "NP_001033228", "name": "origin recognition complex subunit 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033228" }, "gene_names": [ { "name": "ORC3", "type": "recommended", "evidence": [ { "id": "Q32PJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PJ3" } ] }, { "name": "ORC3L", "type": "synonym", "evidence": [ { "id": "NP_001033228", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033228" }, { "id": "Q32PJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PJ3" } ] }, { "name": "ORC3", "type": "synonym", "evidence": [ { "id": "NP_001033228", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033228" } ] } ], "protein_names": [ { "name": "Origin recognition complex subunit 3", "type": "recommended", "evidence": [ { "id": "Q32PJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PJ3/entry#names_and_taxonomy" } ] }, { "name": "origin recognition complex subunit 3", "type": "synonym", "evidence": [ { "id": "NP_001033228", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033228" } ] } ], "function": [ { "annotation": "Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.", "evidence": [ { "database": "UniProtKB", "id": "Q32PJ3", "url": "https://www.uniprot.org/uniprotkb/Q32PJ3#function" }, { "database": "UniProtKB", "id": "Q9UBD5", "url": "https://www.uniprot.org/uniprotkb/Q9UBD5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PJ3", "url": "https://www.uniprot.org/uniprotkb/Q32PJ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ORC3", "url": "https://www.uniprot.org/uniprotkb/Q32PJ3", "locus": { "chromosome": "9", "start_pos": 62267313, "end_pos": 62337163, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016969", "url": "https://www.ensembl.org/id/ENSBTAG00000016969" } ] } } ], "crossref": [ { "id": "Q32PJ3", "url": "https://alphafold.ebi.ac.uk/entry/Q32PJ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd20704", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20704", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523714", "url": "https://www.ncbi.nlm.nih.gov/gene/523714", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR020795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045663", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045663", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045667", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045667", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523714", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523714", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q32PJ3", "url": "https://www.orthodb.org/?gene=Q32PJ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12748", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12748", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12748:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12748:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07034", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07034", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18137", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18137", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19675", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19675", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001033228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033228", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q32PJ3", "url": "https://www.uniprot.org/uniprotkb/Q32PJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PJ3-1", "url": "https://www.uniprot.org/uniprotkb/Q32PJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATSSVSKGCFVFKPNFKKRKISVPIEDYFNKGKNASEDSKLRFETYQLIWQQMKSETERLQEELNKNLFDSLVEFLQTSHSGLWKNSKDWSCEIKLREIPTAALVLGVNVTDHDLTLRSLTEVLQNNVTPYVVSLQAKDCPDMKHFLQKLVSQLMDCKVDVQSKEKESVQVIQKNVHYSMDSLSAWYMSVTQKTDPKMPRKKRTSSSQWQSPPVVLILKDMESFTTKVLQDFIIISSQHLHEFPLILIFGIATSPVVIHRLLPHAVSSLLCIELFQSLSCKEHLTTVLDKLLLTTQFPFKLSEKVLQILTNIFLYHDFSIQNFIKGLQLSLLEHFYSQPLSVLCCNLPEAKRRIRFLSANQCENIRRLPSFRRYVEKQSSEKQVALLTSDKFLKEETQSLLENLHVYHKNYFLVLRCLHQFTSSLPKYPLGRQIRELYCMCLEKSIWDSEEYASVLQLLRLLAKDELMAMLQNCFKLFQSSSGKELGNTAKRIEEFLAQFQSLDETKEEEDTSQSQSKGLQKTDLYHLQKSLLEMKELRSTSKRQTKFEVLREQVVSFVDSLVREYLLPPDTQPLHETLYFSSAHTLRQHLNAAPRIALHTALNNPYYYLKNEALRSEEGCIPNVAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKMDANSVTSGERNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTWGGC", "length": 712, "header": "sp|Q32PJ3-1|ORC3_BOVIN Isoform 1 of Origin recognition complex subunit 3 OS=Bos taurus OX=9913 GN=ORC3 PE=2 SV=1 CANONICAL=Q32PJ3-1" }, "isoforms": [ { "isoform_ac": "Q32PJ3-1", "url": "https://www.uniprot.org/uniprotkb/Q32PJ3/entry#Q32PJ3-1", "sequence": { "sequence": "MATSSVSKGCFVFKPNFKKRKISVPIEDYFNKGKNASEDSKLRFETYQLIWQQMKSETERLQEELNKNLFDSLVEFLQTSHSGLWKNSKDWSCEIKLREIPTAALVLGVNVTDHDLTLRSLTEVLQNNVTPYVVSLQAKDCPDMKHFLQKLVSQLMDCKVDVQSKEKESVQVIQKNVHYSMDSLSAWYMSVTQKTDPKMPRKKRTSSSQWQSPPVVLILKDMESFTTKVLQDFIIISSQHLHEFPLILIFGIATSPVVIHRLLPHAVSSLLCIELFQSLSCKEHLTTVLDKLLLTTQFPFKLSEKVLQILTNIFLYHDFSIQNFIKGLQLSLLEHFYSQPLSVLCCNLPEAKRRIRFLSANQCENIRRLPSFRRYVEKQSSEKQVALLTSDKFLKEETQSLLENLHVYHKNYFLVLRCLHQFTSSLPKYPLGRQIRELYCMCLEKSIWDSEEYASVLQLLRLLAKDELMAMLQNCFKLFQSSSGKELGNTAKRIEEFLAQFQSLDETKEEEDTSQSQSKGLQKTDLYHLQKSLLEMKELRSTSKRQTKFEVLREQVVSFVDSLVREYLLPPDTQPLHETLYFSSAHTLRQHLNAAPRIALHTALNNPYYYLKNEALRSEEGCIPNVAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKMDANSVTSGERNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTWGGC", "length": 712, "header": "sp|Q32PJ3-1|ORC3_BOVIN Isoform 1 of Origin recognition complex subunit 3 OS=Bos taurus OX=9913 GN=ORC3 PE=2 SV=1 CANONICAL=Q32PJ3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 23, "end_pos": 23, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PJ3", "url": "https://www.uniprot.org/uniprotkb/Q32PJ3" } ], "site_lbl": "Ser23" }, { "start_pos": 516, "end_pos": 516, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q32PJ3", "url": "https://www.uniprot.org/uniprotkb/Q32PJ3" } ], "site_lbl": "Ser516" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:523714", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523714", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA replication origin binding", "id": "GO:0003688", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003688", "evidence": [ { "database": "UniProtKB", "id": "Q32PJ3", "url": "https://www.uniprot.org/uniprotkb/Q32PJ3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nuclear pre-replicative complex", "id": "GO:0005656", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005656", "evidence": [ { "database": "UniProtKB", "id": "Q32PJ3", "url": "https://www.uniprot.org/uniprotkb/Q32PJ3" } ], "pmid": "" }, { "name": "DNA replication preinitiation complex", "id": "GO:0031261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031261", "evidence": [ { "database": "UniProtKB", "id": "Q32PJ3", "url": "https://www.uniprot.org/uniprotkb/Q32PJ3" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "Q32PJ3", "url": "https://www.uniprot.org/uniprotkb/Q32PJ3" } ], "pmid": "" }, { "name": "nuclear origin of replication recognition complex", "id": "GO:0005664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005664", "evidence": [ { "database": "UniProtKB", "id": "Q32PJ3", "url": "https://www.uniprot.org/uniprotkb/Q32PJ3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of DNA replication", "id": "GO:0006275", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006275", "evidence": [ { "database": "UniProtKB", "id": "Q32PJ3", "url": "https://www.uniprot.org/uniprotkb/Q32PJ3" } ], "pmid": "" }, { "name": "DNA replication initiation", "id": "GO:0006270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006270", "evidence": [ { "database": "UniProtKB", "id": "Q32PJ3", "url": "https://www.uniprot.org/uniprotkb/Q32PJ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 35, "end_pos": 37, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PJ3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 712, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PJ3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PJ3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 23, 516 ], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 }, { "start_pos": 128, "end_pos": 130 }, { "start_pos": 35, "end_pos": 37 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q32PJ6-1", "uniprot_ac": "Q32PJ6", "uniprot_id": "CIAO1_BOVIN", "mass": { "chemical_mass": 37773.0, "monoisotopic_mass": 37773.0 }, "refseq": { "ac": "NP_001032559", "name": "probable cytosolic iron-sulfur protein assembly protein CIAO1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032559" }, "gene_names": [ { "name": "CIAO1", "type": "recommended", "evidence": [ { "id": "Q32PJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PJ6" } ] }, { "name": "CIAO1", "type": "synonym", "evidence": [ { "id": "NP_001032559", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032559" } ] }, { "name": "WDR39", "type": "synonym", "evidence": [ { "id": "NP_001032559", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032559" }, { "id": "Q32PJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PJ6" } ] } ], "protein_names": [ { "name": "Probable cytosolic iron-sulfur protein assembly protein CIAO1", "type": "recommended", "evidence": [ { "id": "Q32PJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PJ6/entry#names_and_taxonomy" } ] }, { "name": "WD repeat domain 39", "type": "synonym", "evidence": [ { "id": "NP_001032559", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032559" } ] }, { "name": "WD repeat-containing protein 39", "type": "synonym", "evidence": [ { "id": "NP_001032559", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032559" }, { "id": "Q32PJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PJ6/entry#names_and_taxonomy" } ] }, { "name": "cytosolic iron-sulfur protein assembly 1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001032559", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032559" } ] }, { "name": "probable cytosolic iron-sulfur protein assembly protein CIAO1", "type": "synonym", "evidence": [ { "id": "NP_001032559", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032559" } ] } ], "function": [ { "annotation": "Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (By similarity). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (By similarity). Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q32PJ6", "url": "https://www.uniprot.org/uniprotkb/Q32PJ6#function" }, { "database": "HAMAP", "id": "MF_03037", "url": "https://hamap.expasy.org/signature/MF_03037" }, { "database": "UniProtKB", "id": "O76071", "url": "https://www.uniprot.org/uniprotkb/O76071#function" }, { "database": "UniProtKB", "id": "A0ABI0NWE0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWE0#function" }, { "database": "UniProtKB", "id": "ARBA00060126", "url": "https://www.uniprot.org/uniprotkb/ARBA00060126#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q32PJ6", "url": "https://www.uniprot.org/uniprotkb/Q32PJ6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CIAO1", "url": "https://www.uniprot.org/uniprotkb/Q32PJ6", "locus": { "chromosome": "11", "start_pos": 2374474, "end_pos": 2367548, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015659", "url": "https://www.ensembl.org/id/ENSBTAG00000015659" } ] } } ], "crossref": [ { "id": "Q32PJ6", "url": "https://alphafold.ebi.ac.uk/entry/Q32PJ6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015659", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015659", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540069", "url": "https://www.ncbi.nlm.nih.gov/gene/540069", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028608", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028608", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540069", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540069", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IREIRWS", "url": "https://omabrowser.org/oma/group/IREIRWS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q32PJ6", "url": "https://www.orthodb.org/?gene=Q32PJ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19920", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19920", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19920:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19920:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001032559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032559", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NWE0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NWE0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PJ6", "url": "https://www.uniprot.org/uniprotkb/Q32PJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q32PJ6-1", "url": "https://www.uniprot.org/uniprotkb/Q32PJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKDSLVLLSRILAHPDSRCWFLAWNPAGTLLASCGGDRSVRIWGREGDSWICKSVLCEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNEDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSEASWKCVCTLSGFHSRTIYDVAWCQLTGTLATACGDDAIRVFEEDPGSDPQQPTFSLTAHVPQAHSQDVNCVAWNPKERGLLASCSDDGELAFWKYQPSEGI", "length": 339, "header": "sp|Q32PJ6-1|CIAO1_BOVIN Isoform 1 of Probable cytosolic iron-sulfur protein assembly protein CIAO1 OS=Bos taurus OX=9913 GN=CIAO1 PE=2 SV=1 CANONICAL=Q32PJ6-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NWE0-1", "url": "https://www.uniprot.org/uniprotkb/Q32PJ6/entry#A0ABI0NWE0-1", "sequence": { "sequence": "MKDSLVLLSRILAHPDSRCWFLAWNPAGTLLASCGGDRSVRIWGREGDSWICKSVLCEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNEDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSEASWKCVCTLSGFHSRTIYDVAWCQLTGTLATACGDDAIRVFEEDPGSDPQQPTFSLTAHVPQAHSQDVNCSWPSGSISRLKASEPLWLWIESCFPRKCPRTSPVPKRTRRSILDLPLFGPPAFRLGERLRATGPLTLPPLTRSPW", "length": 383, "header": "tr|A0ABI0NWE0-1|A0ABI0NWE0_BOVIN Computationally mapped isoform of Probable cytosolic iron-sulfur protein assembly protein CIAO1 OS=Bos taurus OX=9913 GN=CIAO1 PE=3 SV=1 CANONICAL=Q32PJ6-1" }, "locus": { "chromosome": "11", "start_pos": 2372301, "end_pos": 2367689, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000146202.1", "url": "https://www.ensembl.org/id/ENSBTAT00000146202.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105970.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105970.1" } ] } }, { "isoform_ac": "Q32PJ6-1", "url": "https://www.uniprot.org/uniprotkb/Q32PJ6/entry#Q32PJ6-1", "sequence": { "sequence": "MKDSLVLLSRILAHPDSRCWFLAWNPAGTLLASCGGDRSVRIWGREGDSWICKSVLCEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNEDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSEASWKCVCTLSGFHSRTIYDVAWCQLTGTLATACGDDAIRVFEEDPGSDPQQPTFSLTAHVPQAHSQDVNCVAWNPKERGLLASCSDDGELAFWKYQPSEGI", "length": 339, "header": "sp|Q32PJ6-1|CIAO1_BOVIN Isoform 1 of Probable cytosolic iron-sulfur protein assembly protein CIAO1 OS=Bos taurus OX=9913 GN=CIAO1 PE=2 SV=1 CANONICAL=Q32PJ6-1" }, "locus": { "chromosome": "11", "start_pos": 2372114, "end_pos": 2367689, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020797.4", "url": "https://www.ensembl.org/id/ENSBTAT00000020797.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020797.2", "url": "https://www.ensembl.org/id/ENSBTAP00000020797.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540069", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540069", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZD81-1", "protein_name": "Probable cytosolic iron-sulfur protein assembly protein CIAO1", "gene_name": "CIAO1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKEALALQSRVAAHPEARCWFLAWSPGGALLASCGGDRAVRIWGREGSGWVCRAVLSDGHQRTVRRVAWSPCGSYLASASFDATTCIWKRCEDGFECVTTLEGHENEVKSVAWAPSGSLLATCSRDKSVWVWEVDEEEEYECVSVLNSHTQDVKHVVWHPNQELLASASYDDTVKLYHEEEDDWVCCATLEGHESTVWSVAFDGSGERLASCSDDKTVRIWQCYRPGNEEGVACSGTDPTWKCVCNLSGYHTRTIYDVAWCRLTGALATACGDDAIRVFEESTSSSPQQQQQPTFSLTAHVPRAHSQDVNCVAWNPKEPGLLASCSDDGEIAFWKYQQPEGC", "length": 342 }, "evidence": [ { "id": "Q32PJ6", "url": "https://omabrowser.org/oma/group/Q32PJ6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O76071-1", "protein_name": "Probable cytosolic iron-sulfur protein assembly protein CIAO1", "gene_name": "CIAO1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKDSLVLLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQRPEGL", "length": 339 }, "evidence": [ { "id": "Q32PJ6", "url": "https://omabrowser.org/oma/group/Q32PJ6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O80990-1", "protein_name": "Protein CIA1", "gene_name": "CIA1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDLMEKNLELVEIQKLEGHTDRVWSVAWNPVSSHADGVSPILASCSGDNTVRIWEQSSLSRSWTCKTVLEETHTRTVRSCAWSPSGQLLATASFDGTTGIWKNYGSEFECISTLEGHENEVKSVSWNASGSCLATCSRDKSVWIWEVLEGNEYDCAAVLTGHTQDVKMVQWHPTMDVLFSCSYDNTIKVWWSEDDDGEYQCVQTLGESNNGHSSTVWSISFNAAGDKMVTCSDDLTLKIWGTDIAKMQSGEEYAPWIHLCTLSGYHDRTIYSAHWSRDDIIASGAGDNAIRLFVDSKHDSVDGPSYNLLLKKNKAHENDVNSVQWSPGEGNRLLASASDDGMVKIWQLATKP", "length": 352 }, "evidence": [ { "id": "Q32PJ6", "url": "https://omabrowser.org/oma/group/Q32PJ6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q05583-1", "protein_name": "Cytosolic iron-sulfur protein assembly protein 1", "gene_name": "CIA1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MASINLIKSLKLYKEKIWSFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNGLIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGIVNFWSLEKAA", "length": 330 }, "evidence": [ { "id": "Q32PJ6", "url": "https://omabrowser.org/oma/group/Q32PJ6/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q55DA2-1", "protein_name": "Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog", "gene_name": "ciao1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTDTTKNDKYNLKLIDSMQKEAPYDKVWNLAWHPNGEILATCANDKYIQIWSKDTNGKWGLVQSLEGHEKTVRRVAWSPCGRFLAGASFDASTSIWEKSKDELEFTHVSSLEGHTYEVKSVAWDSTGTLLATCSRDKSIWIWQMEDDNDFECLSINSGHGQDIKCVLWHPNEELLASSSYDDTIKFWKDIDGDWECINTLTGHESSIWDLAFNKDGDKLVSCGEDKLVLFWKFDKENEKWINIFKFKNENSRPIYSIDWSSLTNTIVTGSADDSIIFYEQESDDTPDKYKIILKKKNAHDSDVNCTKWNPKFKNILASCGDDGFIKIWELQDK", "length": 333 }, "evidence": [ { "id": "Q32PJ6", "url": "https://omabrowser.org/oma/group/Q32PJ6/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5M7T1-1", "protein_name": "Probable cytosolic iron-sulfur protein assembly protein CIAO1", "gene_name": "Ciao1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKDALVLQSRVPAHPDSRCWFLAWNPTGTLLASCGGDRKIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYQEEGDDWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCVCTLSGFHTRTIYDVAWCQLTGALATACGDDAIRVFEEDPGSDPQQPTFSLTAHLRQAHSQDVNCVAWNPKEAGLLASCSDDGEVAFWEYHQPAGL", "length": 339 }, "evidence": [ { "id": "Q32PJ6", "url": "https://omabrowser.org/oma/group/Q32PJ6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6P0D9-1", "protein_name": "Probable cytosolic iron-sulfur protein assembly protein ciao1", "gene_name": "ciao1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKGALELQHRVSAHPDSRCWYVAWNPAGTTLATCGGDRAIRIWGKEGDSWECKCVLSDGHQRTVRKVAWSPCGKYLASASFDATTCIWKKTDEDFECLTVLEGHENEVKCVAWAPSGSLLATCSRDKSVWIWEVDEEDEYECLSVVNSHTQDVKHVVWHPTQELLASASYDNKICIYKEEDDDWECRATLEGHESTVWSLTFDPEGRRLASCSDDRTVKIWKESTTGDGSSDESWKCICTLSGFHGRTIYDIAWCRLTGALATACGDDGVRVFSEDPTADPEQPIFALSAHVPKAHNQDVNCVSWNPKEAGLLATCSDNGEFAIWKYNSA", "length": 330 }, "evidence": [ { "id": "Q32PJ6", "url": "https://omabrowser.org/oma/group/Q32PJ6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q7K1Y4-1", "protein_name": "Probable cytosolic iron-sulfur protein assembly protein Ciao1", "gene_name": "Ciao1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGRLILEHTLQGHKGRIWGVAWHPKGNVFASCGEDKAIRIWSLTGNTWSTKTILSDGHKRTIREIRWSPCGQYLASASFDATTAIWSKSSGEFECNATLEGHENEVKSVSWSRSGGLLATCSRDKSVWIWEVAGDDEFECAAVLNPHTQDVKRVVWHPTKDILASASYDNTIKMFAEEPIDNDWDCTATLTSHTSTVWGIDFDADGERLVSCSDDTTIKIWRAYHPGNTAGVATPDQQTVWKCVCTVSGQHSRAIYDVSWCKLTGLIATACGDDGIRIFKESSDSKPDEPTFEQITAEEGAHDQDVNSVQWNPVVAGQLISCSDDGTIKIWKVTE", "length": 335 }, "evidence": [ { "id": "Q32PJ6", "url": "https://omabrowser.org/oma/group/Q32PJ6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q99KN2-1", "protein_name": "Probable cytosolic iron-sulfur protein assembly protein CIAO1", "gene_name": "Ciao1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKDSLVLQSRVPAHPDSRCWFLAWNPSGTLLASCGGDRKIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLSSHTQDVKHVVWHPSQELLASASYDDTVKLYQEEGDDWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHTRTIYDVAWCQLTGALATACGDDAIRVFEEDPGSDPQQPTFSLTAHLRQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWEYHQPAGL", "length": 339 }, "evidence": [ { "id": "Q32PJ6", "url": "https://omabrowser.org/oma/group/Q32PJ6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "iron-sulfur cluster assembly", "id": "GO:0016226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016226", "evidence": [ { "database": "UniProtKB", "id": "Q32PJ6", "url": "https://www.uniprot.org/uniprotkb/Q32PJ6" } ], "pmid": "" }, { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "Q32PJ6", "url": "https://www.uniprot.org/uniprotkb/Q32PJ6" } ], "pmid": "" }, { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "Q32PJ6", "url": "https://www.uniprot.org/uniprotkb/Q32PJ6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosolic [4Fe-4S] assembly targeting complex", "id": "GO:0097361", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097361", "evidence": [ { "database": "UniProtKB", "id": "Q32PJ6", "url": "https://www.uniprot.org/uniprotkb/Q32PJ6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q32PJ6", "url": "https://www.uniprot.org/uniprotkb/Q32PJ6" } ], "pmid": "" }, { "name": "MMXD complex", "id": "GO:0071817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071817", "evidence": [ { "database": "UniProtKB", "id": "Q32PJ6", "url": "https://www.uniprot.org/uniprotkb/Q32PJ6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q32PJ6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 339, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q32PJ6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q32PJ6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q32PJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PJ6" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "LYR motif; required for interaction with HSC20", "eco_id": "ECO_0000250", "start_pos": 176, "end_pos": 178, "start_aa": "Leu", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3B7M4-1", "uniprot_ac": "Q3B7M4", "uniprot_id": "ZN746_BOVIN", "mass": { "chemical_mass": 67972.0, "monoisotopic_mass": 67972.0 }, "refseq": { "ac": "NP_001030418", "name": "zinc finger protein 746", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030418" }, "gene_names": [ { "name": "ZNF746", "type": "recommended", "evidence": [ { "id": "Q3B7M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4" } ] }, { "name": "ZNF746", "type": "synonym", "evidence": [ { "id": "NP_001030418", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030418" } ] } ], "protein_names": [ { "name": "Zinc finger protein 746", "type": "recommended", "evidence": [ { "id": "Q3B7M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 746", "type": "synonym", "evidence": [ { "id": "NP_001030418", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030418" } ] } ], "function": [ { "annotation": "Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M4", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4#function" }, { "database": "UniProtKB", "id": "Q6NUN9", "url": "https://www.uniprot.org/uniprotkb/Q6NUN9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3B7M4", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF746", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4", "locus": { "chromosome": "4", "start_pos": 112486138, "end_pos": 112509045, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031106", "url": "https://www.ensembl.org/id/ENSBTAG00000031106" } ] } } ], "crossref": [ { "id": "Q3B7M4", "url": "https://alphafold.ebi.ac.uk/entry/Q3B7M4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031106", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031106", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "521998", "url": "https://www.ncbi.nlm.nih.gov/gene/521998", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521998", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521998", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PEPCKYP", "url": "https://omabrowser.org/oma/group/PEPCKYP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3B7M4", "url": "https://www.orthodb.org/?gene=Q3B7M4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381:SF393", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381:SF393", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030418", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3B7M4", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3B7M4-1", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEAAAAPISPWTMAATIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGEAPKEWGKLDEWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCSWRRAGPKVPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQLQEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDVSTDAASGVHANFSTTIPPTSWQADLPPHHPSSACSDGTLKLSTAASTEADVKIVIKTEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPVQEGAWESQGSSFPSQDPVLGLREPARPERDLGDPTPTVPQDETSPGDWLFGGVRWGWNFRCKPPAGLNPRTGPEGLPFSSSDNGEAVLDPGQAPRPFNDPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQVSLSAHQRSCGGQPDGVPGAAGSARDGSGLRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDHYRTHTGVRPFTCTVCGKSFIRKDHLRKHQRNHAAGAKPARGQPLPPLPAVPPDPFKSPAAKGPLAPTDLVTDWTCGLSVLGPTDGGDL", "length": 630, "header": "sp|Q3B7M4-1|ZN746_BOVIN Isoform 1 of Zinc finger protein 746 OS=Bos taurus OX=9913 GN=ZNF746 PE=2 SV=1 CANONICAL=Q3B7M4-1" }, "isoforms": [ { "isoform_ac": "Q3B7M4-1", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4/entry#Q3B7M4-1", "sequence": { "sequence": "MAEAAAAPISPWTMAATIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGEAPKEWGKLDEWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCSWRRAGPKVPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQLQEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDVSTDAASGVHANFSTTIPPTSWQADLPPHHPSSACSDGTLKLSTAASTEADVKIVIKTEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPVQEGAWESQGSSFPSQDPVLGLREPARPERDLGDPTPTVPQDETSPGDWLFGGVRWGWNFRCKPPAGLNPRTGPEGLPFSSSDNGEAVLDPGQAPRPFNDPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQVSLSAHQRSCGGQPDGVPGAAGSARDGSGLRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDHYRTHTGVRPFTCTVCGKSFIRKDHLRKHQRNHAAGAKPARGQPLPPLPAVPPDPFKSPAAKGPLAPTDLVTDWTCGLSVLGPTDGGDL", "length": 630, "header": "sp|Q3B7M4-1|ZN746_BOVIN Isoform 1 of Zinc finger protein 746 OS=Bos taurus OX=9913 GN=ZNF746 PE=2 SV=1 CANONICAL=Q3B7M4-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 362, "start_aa": "Thr", "end_pos": 362, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr362", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 625, "start_aa": "Thr", "end_pos": 625, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr625", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:521998", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521998", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AAQ7-1", "protein_name": "Zinc finger protein 746", "gene_name": "Zfp746", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQVLSRLVLLLPGQISPWTMAATIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFSNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGEVPKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCTWRRTGPKVPEVPVDPSPGSGAPVPAPDLLMQIKQEGELQLQEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQADLPPHHPSSACSDGTLKLNTAASTEADVKIVIKTEVQEEEVVATPVHPTDLEAHGTLFAPGQATRFFPSPVQEGAWESQGSSFPSQDPVLGLREPTRPERDIGELSPAIAQEEAPAGDWLFGGVRWGWNFRCKPPVSLNPRTVPEGLPFSSPDNGEAILDPSQAPRPFNDPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQVSLSAHQRSCGLSDGAGTGAASTATGGGGGGGGGGSSAGGSSARDSSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDHYRTHTGVRPFTCTVCGKSFIRKDHLRKHQRNHPAVAKAPAHGQPLPPLPAPPDPFKSPAAKGPMASTDLVTDWTCGLSVLGPNDGGGDL", "length": 656 }, "evidence": [ { "id": "Q3B7M4", "url": "https://omabrowser.org/oma/group/Q3B7M4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3U133-1", "protein_name": "Zinc finger protein 746", "gene_name": "Znf746", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEAAAAPISPWTMAATIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFSNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGEVPKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCTWRRTGPKVPEVPVDPSPGSGAPVPAPDLLMQIKQEGELQLQEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQADLPPHHPSSACSDGTLKLNTAASTEADVKIVIKTEVQEEEVVATPVHPTDLEAHGTLFAPGQATRFFPSPVQEGAWESQGSSFPSQDPVLGLREPTRPERDIGELSPAIAQEEAPAGDWLFGGVRWGWNFRCKPPVGLNPRTVPEGLPFSSPDNGEAILDPSQAPRPFNDPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQVSLSAHQRSCGLSDGAATGAASTTTGGGGGGSGGGGGSSGGGSSARDSSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDHYRTHTGVRPFTCTVCGKSFIRKDHLRKHQRNHPAVAKAPAHGQPLPPLPAPPDPFKSPAAKGPMASTDLVTDWTCGLSVLGPSDGGGDL", "length": 652 }, "evidence": [ { "id": "Q3B7M4", "url": "https://omabrowser.org/oma/group/Q3B7M4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6NUN9-1", "protein_name": "Zinc finger protein 746", "gene_name": "ZNF746", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEAVAAPISPWTMAATIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGESPKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCNWRRPGPKIPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQLQEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQTDLPPHHPSSACSDGTLKLNTAASTEDVKIVIKTEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFGGVRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQVSLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDHYRTHTGVRPFTCTVCGKSFIRKDHLRKHQRNHAAGAKTPARGQPLPTPPAPPDPFKSPASKGPLASTDLVTDWTCGLSVLGPTDGGDM", "length": 644 }, "evidence": [ { "id": "Q3B7M4", "url": "https://omabrowser.org/oma/group/Q3B7M4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M4", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M4", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4" } ], "pmid": "" }, { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M4", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4" } ], "pmid": "" }, { "name": "protein heterooligomerization", "id": "GO:0051291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051291", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M4", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M4", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M4", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M4", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M4", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M4", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M4", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M4", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 242, "end_pos": 244, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3B7M4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 630, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3B7M4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3B7M4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3B7M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7M4" }, { "id": "PRU00119", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00119" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000255", "start_pos": 96, "end_pos": 167, "start_aa": "Leu", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 362, 625 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 242, "end_pos": 244 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3B7M6-1", "uniprot_ac": "Q3B7M6", "uniprot_id": "NEDD1_BOVIN", "mass": { "chemical_mass": 71204.0, "monoisotopic_mass": 71204.0 }, "refseq": { "ac": "NP_001030410", "name": "protein NEDD1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030410" }, "gene_names": [ { "name": "NEDD1", "type": "recommended", "evidence": [ { "id": "Q3B7M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6" } ] }, { "name": "NEDD1", "type": "synonym", "evidence": [ { "id": "NP_001030410", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030410" } ] } ], "protein_names": [ { "name": "Protein NEDD1", "type": "recommended", "evidence": [ { "id": "Q3B7M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6/entry#names_and_taxonomy" } ] }, { "name": "NEDD-1", "type": "synonym", "evidence": [ { "id": "NP_001030410", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030410" }, { "id": "Q3B7M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6/entry#names_and_taxonomy" } ] }, { "name": "Neural precursor cell expressed developmentally down-regulated protein 1", "type": "synonym", "evidence": [ { "id": "Q3B7M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6/entry#names_and_taxonomy" } ] }, { "name": "neural precursor cell expressed developmentally down-regulated protein 1", "type": "synonym", "evidence": [ { "id": "NP_001030410", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030410" } ] }, { "name": "neural precursor cell expressed, developmentally down-regulated 1", "type": "synonym", "evidence": [ { "id": "NP_001030410", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030410" } ] }, { "name": "protein NEDD1", "type": "synonym", "evidence": [ { "id": "NP_001030410", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030410" } ] } ], "function": [ { "annotation": "Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M6", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6#function" }, { "database": "UniProtKB", "id": "Q8NHV4", "url": "https://www.uniprot.org/uniprotkb/Q8NHV4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3B7M6", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NEDD1", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6", "locus": { "chromosome": "5", "start_pos": 61157165, "end_pos": 61105177, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001894", "url": "https://www.ensembl.org/id/ENSBTAG00000001894" } ] } } ], "crossref": [ { "id": "Q3B7M6", "url": "https://alphafold.ebi.ac.uk/entry/Q3B7M6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001894", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001894", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "519463", "url": "https://www.ncbi.nlm.nih.gov/gene/519463", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052818", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052818", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519463", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519463", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GTMVLWD", "url": "https://omabrowser.org/oma/group/GTMVLWD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3B7M6", "url": "https://www.orthodb.org/?gene=Q3B7M6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44414", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44414", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44414:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44414:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2565942", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2565942", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380259", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380259", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380270", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380284", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380284", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380320", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5620912", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8854518", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030410", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030410", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3B7M6", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3B7M6-1", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQENLRFASSGDDVKIWDASSMTLVDKFNPHTAPHAISSVCWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELGEGQKQTCVSLNSTSMYLVSGGLNNTVNIWDLKSKRVHRSLKDHKDEVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPFGHGSNQSIRHLKYSLFKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSTHKAPASGICFSPVNELLFVTVGLDKRIILYDTSSKKLVKTLVADAPLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKSPIKTISAHKTSVQCIAFQYSTVLSKSGLNKGCSNKPTAVNKRTANVSAGGGGAQNPGVVREAATTSIATVPPQPTAAAVGKGAVAPQDKAGLPRSINTDTLSKEAESGKNQDFSNFDDSGKSSLGDMFSPVRDDAVVSKGGDESIGKGDGLDFLPQLNSVFPPRKNPVVSSTSVLHSSPLNVFMGSPGKEENENHDLTAESKKMYLGKQESKDSFKQFAKLISGAETGNLNASPSSNQTRSPEKFEKPEKEIEAQLINEPPGNGSSTPNPKIASSVTAGVAGSLSEKIVDTIGNSRPNAPLSSVQIRFIQNMIQETLDDFREACHRDIVNLQVEMIKQFHMQLNEMHSLLERYSVNEGLVAEIERLREENKRLRAHF", "length": 659, "header": "sp|Q3B7M6-1|NEDD1_BOVIN Isoform 1 of Protein NEDD1 OS=Bos taurus OX=9913 GN=NEDD1 PE=2 SV=1 CANONICAL=Q3B7M6-1" }, "isoforms": [ { "isoform_ac": "Q3B7M6-1", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6/entry#Q3B7M6-1", "sequence": { "sequence": "MQENLRFASSGDDVKIWDASSMTLVDKFNPHTAPHAISSVCWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELGEGQKQTCVSLNSTSMYLVSGGLNNTVNIWDLKSKRVHRSLKDHKDEVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPFGHGSNQSIRHLKYSLFKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSTHKAPASGICFSPVNELLFVTVGLDKRIILYDTSSKKLVKTLVADAPLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKSPIKTISAHKTSVQCIAFQYSTVLSKSGLNKGCSNKPTAVNKRTANVSAGGGGAQNPGVVREAATTSIATVPPQPTAAAVGKGAVAPQDKAGLPRSINTDTLSKEAESGKNQDFSNFDDSGKSSLGDMFSPVRDDAVVSKGGDESIGKGDGLDFLPQLNSVFPPRKNPVVSSTSVLHSSPLNVFMGSPGKEENENHDLTAESKKMYLGKQESKDSFKQFAKLISGAETGNLNASPSSNQTRSPEKFEKPEKEIEAQLINEPPGNGSSTPNPKIASSVTAGVAGSLSEKIVDTIGNSRPNAPLSSVQIRFIQNMIQETLDDFREACHRDIVNLQVEMIKQFHMQLNEMHSLLERYSVNEGLVAEIERLREENKRLRAHF", "length": 659, "header": "sp|Q3B7M6-1|NEDD1_BOVIN Isoform 1 of Protein NEDD1 OS=Bos taurus OX=9913 GN=NEDD1 PE=2 SV=1 CANONICAL=Q3B7M6-1" }, "locus": { "chromosome": "5", "start_pos": 61156225, "end_pos": 61107379, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002464.8", "url": "https://www.ensembl.org/id/ENSBTAT00000002464.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002464.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002464.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 357, "start_aa": "Thr", "end_pos": 357, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr357", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 382, "end_pos": 382, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by PLK1", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M6", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6" } ], "site_lbl": "Thr382" }, { "start_pos": 411, "end_pos": 411, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M6", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6" } ], "site_lbl": "Ser411" }, { "start_pos": 426, "end_pos": 426, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PLK1", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M6", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6" } ], "site_lbl": "Ser426" }, { "start_pos": 468, "end_pos": 468, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M6", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6" } ], "site_lbl": "Ser468" }, { "start_pos": 515, "end_pos": 515, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M6", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6" } ], "site_lbl": "Ser515" }, { "start_pos": 549, "end_pos": 549, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by CDK1", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M6", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6" } ], "site_lbl": "Thr549" }, { "start_pos": 636, "end_pos": 636, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PLK1", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M6", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6" } ], "site_lbl": "Ser636" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:519463", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519463", "resource": "KEGG Pathway" }, { "id": "R-BTA-2565942", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2565942", "resource": "Reactome", "description": "Regulation of PLK1 Activity at G2/M Transition" }, { "id": "R-BTA-380259", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380259", "resource": "Reactome", "description": "Loss of Nlp from mitotic centrosomes" }, { "id": "R-BTA-380270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "resource": "Reactome", "description": "Recruitment of mitotic centrosome proteins and complexes" }, { "id": "R-BTA-380284", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380284", "resource": "Reactome", "description": "Loss of proteins required for interphase microtubule organization from the centrosome" }, { "id": "R-BTA-380320", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "resource": "Reactome", "description": "Recruitment of NuMA to mitotic centrosomes" }, { "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" }, { "id": "R-BTA-8854518", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "resource": "Reactome", "description": "AURKA Activation by TPX2" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7IHZ1-1", "protein_name": "Protein NEDD1", "gene_name": "Nedd1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MQENLRFASSGDDIKIWDASSMTLVDKFNPHTSPHGISSLCWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVDLNHTSMYLASGGLNNTVNIWDLKSKRVHRSLKDHKGEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSGTPFGHGSNQPVRHVKYSLFRKSLLGSVSDNGVVTLWDVNSQSSYHSFDSTHKAPASGICFSPVNELLFVTIGLDKRIILYDTSSKKLVQTLVADTPLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTSLMKSSLSKGCSNKTTSVSKRSISVSGGSGAAQNSGTVRGASAPSIATVLPQPVRTAVGRGAVAVQDKAGLHRSINTDILSKEADGGRSQDFSNFDDTGENSLGDMFSPVRDDGVVNKGGDESTGKGDGLDFLSQLMSSVFPSRKNPITSGTLVLHSSPLNLFTDSPGKEENESHDLTAETKKTCLGKQEPKDSLKQLISSGAEPGILNPSPSSNQTRNLENFEKPEKQIEAQLIHEPSVNRSSTPIPKVASSVAAGIASSLSEKIVDTLGNNQPSAPLTSVQIRFIQNMIQETMDDFREACHKDIVNLQVEMIKQFHVQMNEIHCLLERYSVNEGLVAEIERLREENKRLRAHF", "length": 658 }, "evidence": [ { "id": "Q3B7M6", "url": "https://omabrowser.org/oma/group/Q3B7M6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0ABK0L1L0-1", "protein_name": "Protein NEDD1", "gene_name": "Nedd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLQSPNRNIVYNSTGSAMQENLRFASSGDDVKIWDASFLTLVDKFNPHTSPHGISSICWSSNNNFLVTASSGGDKIVVSSCKCKPVPLLELAEGQKQTCVDLNSTSMYLASGGLNNTVNIWDLKSKRLHRSLKDHKREVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPFGHGSKQPVRHIKYSLFRKSLLGSVSDNGVVTLWDVNSQSAYHSFDSTHKAPASGLCFSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLTAVDFMPDGASLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTSLTKASLNKGCSNKATAANKRSVPVGSSSGAAQNSGIVREAPSPSIATVLPQPVTTAVGKGAGAAQDEAGLPRSKNTDILSKETDAGKSQDFSSFDDTGKSSLGDMFSPIRDDAVVNKGGDESVGKGDGLDFLPQLNSVFPLRKNAGSSSTLVLHSSPFNVLMGTGKEEHESHELSAESKKAHLGKPEPKDSLKQFTKLISSGAEPGILNTCPSSNQARNLEKFEKPEKDIEVQLMHEPSVNGPSTPVPKAASSVTAGVASSLSEKIVDTLGNSRPAAPLTSVQIRFIQNMIQETLDDFREACHRDIVNLQVEMIKQFHMQLNEMHSLLERYSVNEGLVAEIERLREENKRLRAHF", "length": 676 }, "evidence": [ { "id": "Q3B7M6", "url": "https://omabrowser.org/oma/group/Q3B7M6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B3H5K9-1", "protein_name": "Protein NEDD1", "gene_name": "NEDD1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MMSNLVEPSWRLLAASGGDTVKLFDVSADSGDPCVLSYTPSPGCAVNSVKWNHTNLVVASTGEDKKISLWRKNGQSLGTVPVTGKDGGDSAEECLSAISFSKKGSRYICSGGTGQIVKIWDLQRKLCIKKLKGHTSTITGVMYNCKDEHLASVSVGGDLIVHNLASGARATELKDPNGQVLRLLDYSRSSRHLLVTAGDDGTVHLWDTTGRSPKMSWLKQHSAPTAGVCFSPSNEKIIASVGMDKKLYTYDSGSRRSSSCIAYEAPFSSLAFGDNGYILVAGTSNGRVVFYDIRGKPQPVTVLHAFSNSEDVTSLSWQTSKPVIVNEKNYTSEMALLGSTVEDSVVIPDPLPSTTPSASQSAMAPGSRGVSASTVNASSVEQTPNRNHLWPSGPLGRLHALRANDSYNDDMGVFSPIIDVSSVEKWADSEGYNNKDHLVVDNKPSSLLFPSSSKGYSFGDNGSKEHPIFDWKPSSTSKQDDPRAAFSSFGSITPTASSKSEDSALTPPEAWGGDKFSEKFNQLANEKFSDKFSHLHAPSRLAVSSTGASTSGSMFSSSRDFPLSHGQTNFANASLEFPRIRDFSSTFETSSTQTDNNLPSSPLFTKGITAPGNIDSLRLSPNFTRRFSTYAERISTTSSFSDGASLSLGGSPKIKKTGSETREEVLNHLLARPETVVATEAGAMPLMNQGGLKQSQTDQQQVMGSSNFTLQLFQRTLEGTLDSFQNSIHDDVRNLHIEILRQFHMHEMEMSKVLSSILENQAEQMKELKLLRKENQELRQRL", "length": 782 }, "evidence": [ { "id": "Q3B7M6", "url": "https://omabrowser.org/oma/group/Q3B7M6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P33215-1", "protein_name": "Protein NEDD1", "gene_name": "Nedd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQENLRFASSGDDVKIWDASFLTLVDKFNPHTSPHGISSICWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVDLNSTSMYLASGGLNNTVNIWDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPFGHGSKQPIRHIKYSLFRKSLLGSVSDNGVVTLWDVNSQSSYHTFDSTHKAPASGICFSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTSLTKASLSKGSSNKATAVNKRSVPVSSSSGAAQNSGIVREAPSPSIATVLPQPVTTALGKGSGAAQDEAGLARSKSTDIFSKETDAGKSQDFSSFDDTGKNSLGDMFSPIRDDAVVSKGGDESIGKGDGLDFLPQLNSVFPLRKNAGASSSLVLHSSPLNVLMGSSGKEENESHEPSAESKRAYLGKQEPKDAMKQFTKLISSGAEPGILNTCPSSNQARNLEKFEKPEKDIEAQLIHEPSVNGSSTTVPKAASSVTAGVASSLSEKIVDTLGNSRPGAPLTSVQIRFIQNMIQETLDDFREACHRDIVNLQVEMIKQFHIQLNEMHSLLERYSVNEGLVAEIERLREENKRLRAHF", "length": 660 }, "evidence": [ { "id": "Q3B7M6", "url": "https://omabrowser.org/oma/group/Q3B7M6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NHV4-1", "protein_name": "Protein NEDD1", "gene_name": "NEDD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQENLRFASSGDDIKIWDASSMTLVDKFNPHTSPHGISSICWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVNLNSTSMYLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPFGHGSNQSVRHLKYSLFKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSVHKAPASGICFSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTVLTKSSLNKGCSNKPTTVNKRSVNVNAASGGVQNSGIVREAPATSIATVLPQPMTSAMGKGTVAVQEKAGLPRSINTDTLSKETDSGKNQDFSSFDDTGKSSLGDMFSPIRDDAVVNKGSDESIGKGDGFDFLPQLNSVFPPRKNPVTSSTSVLHSSPLNVFMGSPGKEENENRDLTAESKKIYMGKQESKDSFKQLAKLVTSGAESGNLNTSPSSNQTRNSEKFEKPENEIEAQLICEPPINGSSTPNPKIASSVTAGVASSLSEKIADSIGNNRQNAPLTSIQIRFIQNMIQETLDDFREACHRDIVNLQVEMIKQFHMQLNEMHSLLERYSVNEGLVAEIERLREENKRLRAHF", "length": 660 }, "evidence": [ { "id": "Q3B7M6", "url": "https://omabrowser.org/oma/group/Q3B7M6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mitotic cell cycle", "id": "GO:0000278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M6", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M6", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6" } ], "pmid": "" }, { "name": "microtubule nucleation", "id": "GO:0007020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007020", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M6", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M6", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M6", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M6", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6" } ], "pmid": "" }, { "name": "apical part of cell", "id": "GO:0045177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M6", "url": "https://www.uniprot.org/uniprotkb/Q3B7M6" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", 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CANONICAL=Q3B7M9-1" }, "isoforms": [ { "isoform_ac": "Q3B7M9-1", "url": "https://www.uniprot.org/uniprotkb/Q3B7M9/entry#Q3B7M9-1", "sequence": { "sequence": 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CANONICAL=Q3B7M9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 15, "end_pos": 15, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PHK; in form phosphorylase A", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M9", "url": "https://www.uniprot.org/uniprotkb/Q3B7M9" } ], "site_lbl": "Ser15" }, { "start_pos": 197, "end_pos": 197, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M9", "url": "https://www.uniprot.org/uniprotkb/Q3B7M9" } ], "site_lbl": "Tyr197" }, { "start_pos": 473, "end_pos": 473, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M9", "url": "https://www.uniprot.org/uniprotkb/Q3B7M9" } ], "site_lbl": "Tyr473" } ], "glycation": [], "keywords": [ "enzyme", "glycosyltransferase-activity" ], "publication": [], "pathway": [ { "id": "bta:505560", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505560", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M9", "url": "https://www.uniprot.org/uniprotkb/Q3B7M9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "Q3B7M9", "url": "https://www.uniprot.org/uniprotkb/Q3B7M9" } ], "pmid": "" }, { "name": "glycogen phosphorylase activity", "id": "GO:0008184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008184", "evidence": [ { "database": "UniProtKB", 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"n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHE2-1", "uniprot_ac": "Q3MHE2", "uniprot_id": "PRP4_BOVIN", "mass": { "chemical_mass": 58399.0, "monoisotopic_mass": 58399.0 }, "refseq": { "ac": "NP_001029502", "name": "U4/U6 small nuclear ribonucleoprotein Prp4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029502" }, "gene_names": [ { "name": "PRPF4", "type": "recommended", "evidence": [ { "id": "Q3MHE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHE2" } ] }, { "name": "PRPF4", "type": "synonym", "evidence": [ { "id": "NP_001029502", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029502" } ] } ], "protein_names": [ { "name": "U4/U6 small nuclear ribonucleoprotein Prp4", "type": "recommended", "evidence": [ { "id": "Q3MHE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHE2/entry#names_and_taxonomy" } ] }, { "name": "PRP4 pre-mRNA processing factor 4 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029502", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029502" } ] }, { "name": "U4/U6 small nuclear ribonucleoprotein Prp4", "type": "synonym", "evidence": [ { "id": "NP_001029502", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029502" } ] }, { "name": "U4/U6 snRNP 60 kDa protein", "type": "synonym", "evidence": [ { "id": "NP_001029502", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029502" }, { "id": "Q3MHE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHE2/entry#names_and_taxonomy" } ] }, { "name": "WD splicing factor Prp4", "type": "synonym", "evidence": [ { "id": "NP_001029502", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029502" }, { "id": "Q3MHE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHE2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE2", "url": "https://www.uniprot.org/uniprotkb/Q3MHE2#function" }, { "database": "UniProtKB", "id": "O43172", "url": "https://www.uniprot.org/uniprotkb/O43172#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHE2", "url": "https://www.uniprot.org/uniprotkb/Q3MHE2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRPF4", "url": "https://www.uniprot.org/uniprotkb/Q3MHE2", "locus": { "chromosome": "8", "start_pos": 102538052, "end_pos": 102517180, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004571", "url": "https://www.ensembl.org/id/ENSBTAG00000004571" } ] } } ], "crossref": [ { "id": "Q3MHE2", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHE2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004571", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004571", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508735", "url": "https://www.ncbi.nlm.nih.gov/gene/508735", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014906", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014906", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036285", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036285", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508735", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508735", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LNEPICY", "url": "https://omabrowser.org/oma/group/LNEPICY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3MHE2", "url": "https://www.orthodb.org/?gene=Q3MHE2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19846", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19846", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19846:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19846:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08799", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08799", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029502", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3MHE2", "url": "https://www.uniprot.org/uniprotkb/Q3MHE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHE2-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHE2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASTRPSSTATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGLLGKEGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPHSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDQKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVTWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE", "length": 521, "header": "sp|Q3MHE2-1|PRP4_BOVIN Isoform 1 of U4/U6 small nuclear ribonucleoprotein Prp4 OS=Bos taurus OX=9913 GN=PRPF4 PE=2 SV=1 CANONICAL=Q3MHE2-1" }, "isoforms": [ { "isoform_ac": "Q3MHE2-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHE2/entry#Q3MHE2-1", "sequence": { "sequence": "MASTRPSSTATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGLLGKEGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPHSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDQKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVTWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE", "length": 521, "header": "sp|Q3MHE2-1|PRP4_BOVIN Isoform 1 of U4/U6 small nuclear ribonucleoprotein Prp4 OS=Bos taurus OX=9913 GN=PRPF4 PE=2 SV=1 CANONICAL=Q3MHE2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508735", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508735", "resource": "KEGG Pathway" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AGK5-1", "protein_name": "U4/U6 small nuclear ribonucleoprotein Prp4", "gene_name": "PRPF4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRSLMICSRLLCSAPSAMPAASSPAATSDSSRCFLRLCGAERPRQGAPEAGRALAGRPHGSRAHLQVLPDAFELLDVVQLQLQPRRLPPQHHSTAAVSRPAPRGAPPLPPTKSKPSEEGDAPPAKRAPIFYGSLEEKERERLAKGESGLLGKEGMKAALEAGNINISSGEVFELEDHMSERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTRKDDDRSKKSKEEYQQTWYHEGPRSLKTARLWLANYSLPRAVKRLEEARLLKEIPEATRTSQRQELHKSLRSLNNFCSQIGDDRPLSYCHFSPNSKLLATACWSGLCKLWSVPDCNLVHTLRGHSTNVGAIVFHPKATVSLDKKDVNLASCAADGSVKLWSLESDEPVADIEGHSMRVARVMWHPSGRFLGTTCYDHSWRLWDLEAQEEILHQEGHSKGVYDIAFHTDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGLNFSPNGYHVATGSGDNTCKVWDLRQRKCIYTIPAHQNLVTGVKFEPNHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISLDGQLIATCSYDRTFKLWTAE", "length": 621 }, "evidence": [ { "id": "Q3MHE2", "url": "https://omabrowser.org/oma/group/Q3MHE2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A7J8-1", "protein_name": "U4/U6 small nuclear ribonucleoprotein Prp4", "gene_name": "Prpf4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASSRASSTTTKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKEGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVSLDQKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGDFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE", "length": 521 }, "evidence": [ { "id": "Q3MHE2", "url": "https://omabrowser.org/oma/group/Q3MHE2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HI03-1", "protein_name": "U4/U6 small nuclear ribonucleoprotein Prp4", "gene_name": "Prpf4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASSRASSTATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKEGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVSLDQKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGDFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE", "length": 521 }, "evidence": [ { "id": "Q3MHE2", "url": "https://omabrowser.org/oma/group/Q3MHE2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LDL8-1", "protein_name": "U4/U6 small nuclear ribonucleoprotein Prp4", "gene_name": "PRPF4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASSRASSTATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKEGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDQKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE", "length": 521 }, "evidence": [ { "id": "Q3MHE2", "url": "https://omabrowser.org/oma/group/Q3MHE2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O22212-1", "protein_name": "U4/U6 small nuclear ribonucleoprotein PRP4-like protein", "gene_name": "LIS", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEPNKDDNVSLAATAQISAPPVLQDASSLPGFSAIPPVVPPSFPPPMAPIPMMPHPPVARPPTFRPPVSQNGGVKTSDSDSESDDEHIEISEESKQVRERQEKALQDLLVKRRAAAMAVPTNDKAVRDRLRRLGEPITLFGEQEMERRARLTQLLTRYDINGQLDKLVKDHEEDVTPKEEVDDEVLEYPFFTEGPKELREARIEIAKFSVKRAAVRIQRAKRRRDDPDEDMDAETKWALKHAKHMALDCSNFGDDRPLTGCSFSRDGKILATCSLSGVTKLWEMPQVTNTIAVLKDHKERATDVVFSPVDDCLATASADRTAKLWKTDGTLLQTFEGHLDRLARVAFHPSGKYLGTTSYDKTWRLWDINTGAELLLQEGHSRSVYGIAFQQDGALAASCGLDSLARVWDLRTGRSILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWDLRMRKSLYIIPAHANLVSQVKYEPQEGYFLATASYDMKVNIWSGRDFSLVKSLAGHESKVASLDITADSSCIATVSHDRTIKLWTSSGNDDEDEEKETMDIDL", "length": 554 }, "evidence": [ { "id": "Q3MHE2", "url": "https://omabrowser.org/oma/group/Q3MHE2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "O43172-1", "protein_name": "U4/U6 small nuclear ribonucleoprotein Prp4", "gene_name": "PRPF4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASSRASSTQATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKDGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE", "length": 522 }, "evidence": [ { "id": "Q3MHE2", "url": "https://omabrowser.org/oma/group/Q3MHE2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P20053-1", "protein_name": "U4/U6 small nuclear ribonucleoprotein PRP4", "gene_name": "PRP4", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSKYIALENLPVDLQHKGATQNESTADILKQLPHERLQAVLEKIPEEDLEVRRLLSILKKPEVVENEDVQQRRIRLAEILMVDEIDLENINNMENINGEEVDEEDDEDFFTPATSELIFARRFLINYSLERSRKRLQKEMERHQKFNTRQELLSRRTELQRMANLELAGSQLVSTKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN", "length": 465 }, "evidence": [ { "id": "Q3MHE2", "url": "https://omabrowser.org/oma/group/Q3MHE2/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54K20-1", "protein_name": "WD40 repeat-containing protein", "gene_name": "prpf4", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDNKRIYFGAIKKENLKQKKDSINSIGSSGGGDEENQAEFLPFSKHTKRSQEQHQKVLDEYERKKRAKQVIVPTIDNLVKLKLRELLEPIILFGEKPEHRRSRLREILIERNIIDGTPLLISNKKEQEEQEQLEGSDEENFLTEGTEELKTARINISIYSLKKSQQRLLHLKKQREIELSIQKENDNLKNQFEEKQQKRIQKKLRLHQQLENDNMNIDEEEDDDDDDDGDDGDDLNMMVKIKTEFEKDMEYTVKELKNYYSSVSQIGDDRPLSMGVFSPDGKNVAIGSWSGVSKVWSVSGQKKQILAGHSQRVSCIAYHPLSGIDGNHTKNLVNIATTSADSTCKLWPLLNNDNNNNNNNNNDNEEEDNDATVSIETQPILSLEGHSDVVNRCSFHPCGRYITTSSNDKSWRLWDLESGGKCLLDQEGHSDGVMGISIQSDGSLLATGSQDGLVRIWDLRSGRPILYFQGHSKQVISVDWSPNGYQLASSSEDNTVVIWDIRKKEQSCQILAHNSIVSCVKFQKQSTQTNNNNNNSSPGCVNYLATCSFDGKIKTWSPNTWSPLATFEGHSSKVTSIDLTNSKILSTSFDKTWKIWSNDN", "length": 600 }, "evidence": [ { "id": "Q3MHE2", "url": "https://omabrowser.org/oma/group/Q3MHE2/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9DAW6-1", "protein_name": "U4/U6 small nuclear ribonucleoprotein Prp4", "gene_name": "Prpf4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASSRASSTTTKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKEGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVSLDQKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGDFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE", "length": 521 }, "evidence": [ { "id": "Q3MHE2", "url": "https://omabrowser.org/oma/group/Q3MHE2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VVI0-1", "protein_name": "U4-U6 small nuclear riboprotein factor 60K", "gene_name": "U4-U6-60K", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSDDDDIQYIKRQRTLHYGSLEESERKRQNAAASGAAATTTSGTTASSGAGTTTTGTGGQLEDIDSDEDYEESTKKTSNAKQAGAPPPTAATLANKIDDDYFDLEMEMERDKVALLEEFERKKRARQINVSTDDTEIKSNLRQLNEPICYFGEGPAERRRRLKELLAGLGENAINKRQYEDEERKQQQREQDQATWYHEGPDSLRIARLWLADYSLPRAKDRLVRAREALEVPSAARAGRMVEMQKKLQSLAPLCSQVGDTRPVSSAAFSEDSSLLLTSSWSGLCKLWSVPDCELKQTLRGHASYVGGVALRPGVKADEENVVAMASGGHDGAVKLWGFNNEESIADITGHMPHRVSKVAFHPSGRFLATACYDSSWRLWDLEQKTEVLHQEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLGAVFGVDFSPNGFHIATGSQDNTCKIWDLRRRQPVYTIPAHTNLISDVKYQQECGSFLVTCSYDSTTKIWSNKTWQPLKTLQGHDNKVISVDIAPNSQYIATTSFDRTFKLWSPDS", "length": 553 }, "evidence": [ { "id": "Q3MHE2", "url": "https://omabrowser.org/oma/group/Q3MHE2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "U4 snRNA binding", "id": "GO:0030621", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030621", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE2", "url": "https://www.uniprot.org/uniprotkb/Q3MHE2" } ], "pmid": "" }, { "name": "U6 snRNA binding", "id": "GO:0017070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017070", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE2", "url": "https://www.uniprot.org/uniprotkb/Q3MHE2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE2", "url": "https://www.uniprot.org/uniprotkb/Q3MHE2" } ], "pmid": "" }, { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE2", "url": "https://www.uniprot.org/uniprotkb/Q3MHE2" } ], "pmid": "" }, { "name": "U4/U6 snRNP", "id": "GO:0071001", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071001", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE2", "url": "https://www.uniprot.org/uniprotkb/Q3MHE2" } ], "pmid": "" }, { "name": "spliceosomal snRNP complex", "id": "GO:0097525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097525", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE2", "url": "https://www.uniprot.org/uniprotkb/Q3MHE2" } ], "pmid": "" }, { "name": "U4/U6 x U5 tri-snRNP complex", "id": "GO:0046540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046540", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE2", "url": "https://www.uniprot.org/uniprotkb/Q3MHE2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "Q3MHE2", "url": "https://www.uniprot.org/uniprotkb/Q3MHE2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 182, "end_pos": 184, "annotation": "n_glycosylation_sequon" }, { "start_pos": 413, "end_pos": 415, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHE2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 521, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHE2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHE2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 182, "end_pos": 184 }, { "start_pos": 413, "end_pos": 415 }, { "start_pos": 65, "end_pos": 67 }, { "start_pos": 99, "end_pos": 101 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHG0-1", "uniprot_ac": "Q3MHG0", "uniprot_id": "COG4_BOVIN", "mass": { "chemical_mass": 88856.0, "monoisotopic_mass": 88856.0 }, "refseq": { "ac": "NP_001029755", "name": "conserved oligomeric Golgi complex subunit 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029755" }, "gene_names": [ { "name": "COG4", "type": "recommended", "evidence": [ { "id": "Q3MHG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHG0" } ] }, { "name": "COG4", "type": "synonym", "evidence": [ { "id": "NP_001029755", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029755" } ] } ], "protein_names": [ { "name": "Conserved oligomeric Golgi complex subunit 4", "type": "recommended", "evidence": [ { "id": "Q3MHG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHG0/entry#names_and_taxonomy" } ] }, { "name": "COG complex subunit 4", "type": "synonym", "evidence": [ { "id": "NP_001029755", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029755" }, { "id": "Q3MHG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHG0/entry#names_and_taxonomy" } ] }, { "name": "Component of oligomeric Golgi complex 4", "type": "synonym", "evidence": [ { "id": "Q3MHG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHG0/entry#names_and_taxonomy" } ] }, { "name": "conserved oligomeric Golgi complex subunit 4", "type": "synonym", "evidence": [ { "id": "NP_001029755", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029755" } ] } ], "function": [ { "annotation": "Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1.", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG0", "url": "https://www.uniprot.org/uniprotkb/Q3MHG0#function" }, { "database": "UniProtKB", "id": "Q9H9E3", "url": "https://www.uniprot.org/uniprotkb/Q9H9E3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHG0", "url": "https://www.uniprot.org/uniprotkb/Q3MHG0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COG4", "url": "https://www.uniprot.org/uniprotkb/Q3MHG0", "locus": { "chromosome": "18", "start_pos": 1643268, "end_pos": 1617958, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012988", "url": "https://www.ensembl.org/id/ENSBTAG00000012988" } ] } } ], "crossref": [ { "id": "Q3MHG0", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHG0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012988", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012988", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533007", "url": "https://www.ncbi.nlm.nih.gov/gene/533007", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013167", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013167", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048682", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048682", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048684", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048684", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533007", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533007", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RASECQQ", "url": "https://omabrowser.org/oma/group/RASECQQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3MHG0", "url": "https://www.orthodb.org/?gene=Q3MHG0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24016", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24016", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24016:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24016:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08318", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08318", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20662", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20662", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20663", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20663", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6807878", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811438", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811438", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029755", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3MHG0", "url": "https://www.uniprot.org/uniprotkb/Q3MHG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHG0-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHG0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADLDSPQKLSGVPRPPDGVGGGSCSEISTELIRSLTDLQELEAVYERLCGEEKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRNEDYEQAAAHIHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVTEKFAVATKEGDLPQVERFFKIFPLLGLHEEGLSKFSEYLCKQVASKAEENLLLVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYRQQFRHVQSNLMRNSTSEKIEPRELDPILTEVTLMNARSELYLRFLRKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYITMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFRDVLCHKLRMGFPATTLQDIQRGVTSAVSIMHSSLQQGKFDTKGIESTDEAKLSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSGKFRDLLQEGLTELNSTAIKPQVQPWINTFLSVSHNIEEEEFSDYEANDPWVQQFILNLEQQMAEFKAGLSPVIYDSLTSLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGANSGPLTWRLTPAEVRQVLALRIDFRSEDIKRLRL", "length": 785, "header": "sp|Q3MHG0-1|COG4_BOVIN Isoform 1 of Conserved oligomeric Golgi complex subunit 4 OS=Bos taurus OX=9913 GN=COG4 PE=2 SV=1 CANONICAL=Q3MHG0-1" }, "isoforms": [ { "isoform_ac": "Q3MHG0-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHG0/entry#Q3MHG0-1", "sequence": { "sequence": "MADLDSPQKLSGVPRPPDGVGGGSCSEISTELIRSLTDLQELEAVYERLCGEEKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRNEDYEQAAAHIHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVTEKFAVATKEGDLPQVERFFKIFPLLGLHEEGLSKFSEYLCKQVASKAEENLLLVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYRQQFRHVQSNLMRNSTSEKIEPRELDPILTEVTLMNARSELYLRFLRKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYITMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFRDVLCHKLRMGFPATTLQDIQRGVTSAVSIMHSSLQQGKFDTKGIESTDEAKLSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSGKFRDLLQEGLTELNSTAIKPQVQPWINTFLSVSHNIEEEEFSDYEANDPWVQQFILNLEQQMAEFKAGLSPVIYDSLTSLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGANSGPLTWRLTPAEVRQVLALRIDFRSEDIKRLRL", "length": 785, "header": "sp|Q3MHG0-1|COG4_BOVIN Isoform 1 of Conserved oligomeric Golgi complex subunit 4 OS=Bos taurus OX=9913 GN=COG4 PE=2 SV=1 CANONICAL=Q3MHG0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 6, "end_pos": 6, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG0", "url": "https://www.uniprot.org/uniprotkb/Q3MHG0" } ], "site_lbl": "Ser6" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:533007", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533007", "resource": "KEGG Pathway" }, { "id": "R-BTA-6807878", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "resource": "Reactome", "description": "COPI-mediated anterograde transport" }, { "id": "R-BTA-6811438", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811438", "resource": "Reactome", "description": "Intra-Golgi traffic" }, { "id": "R-BTA-6811440", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "resource": "Reactome", "description": "Retrograde transport at the Trans-Golgi-Network" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480V3B9-1", "protein_name": "Conserved oligomeric Golgi complex subunit 4", "gene_name": "COG4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGIKMADLDSPQKLSGVPPPPEGVGGGRCSEISTELIRSLTELQELEAVYERLCGEEKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRNEDYEQAAAHIHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVTEKFAIATKEGDLPQVERFFKIFPLLGLHEDGLSKFSEYLCKQVASKAEENLLLVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQFRHVQNNLMRNSTSEKIEPRELDPILTEVTLMNARSELYLRFLRKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYITMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFRDVLCNKLRMGFPATTLQDIQRGVTSAVNIMHSSLQQGKFDTKGIESTDEAKLSFLVTLNNVEVCSENISTLKKTLESDCMKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLTELNSTAIKPQVQPWINTFLSVSHNIEEEEFNDYEANDPWVQQFILNLEQQMAEFKAGLSPVIYDSLTSLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGANSGPLTWRLTPAEVRQVLALRIDFRSEDIKRLRL", "length": 789 }, "evidence": [ { "id": "Q3MHG0", "url": "https://omabrowser.org/oma/group/Q3MHG0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZZM3-1", "protein_name": "Conserved oligomeric Golgi complex subunit 4", "gene_name": "Cog4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDSPKGCRASAEGTSRARKRRVGTKMADVESPPKLSGAPPPPEGVGGGHCSEISTELIRSLTELQELEAVYERLCGEEKVVEKELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHIHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAAATKEGDLPQVERFFKIFPLLGLHEDGLSKFSEYLCKQVASKAEENLLLVLGSDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLFTLIKYLQVECDTQVEKVVNKFIKQRDYHQQFRLVQSNLMRNSATEKIEPRELDPVLTEVTLMNARSELYLRFLRKRISADFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELVGFYITMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSNIDCLCAMINLATRELEADFRDVLCNKLRMGFPATTLQDIQRGVTSAVNIMHSSLQQGKFDTKGIESTDEAKLSFLVTLNNVEVCSENISTLKKTLEEEFNDYEANDPWVQQFILSLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGANSGPLTWRLTPAEVRQVLALRIDFRNEDIKRLRL", "length": 740 }, "evidence": [ { "id": "Q3MHG0", "url": "https://omabrowser.org/oma/group/Q3MHG0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q29RB1-1", "protein_name": "Conserved oligomeric Golgi complex subunit 4", "gene_name": "cog4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEEAASPARRRGGPAGVSAVQTDTIEALTELEDLERVYAQLCAEEAEVQVELDALVGQQNNIETKMLSLQRMGPNLQLIEGDAVQLSGMINFTCSLAENVSSKVRQLDLTKKRLYQAIQRADDILDLKFCTDGVQTALRNQDYEQAAAHIHRYLSLDQSVIELSKQGGEGSAVEASLALLQEAERNLKTLVTTRLEEAVATGDLPQVERFFKILPLLGLHEQGLARFAQYLCSQLASKAEENLILAVGSDLGERRAPVIFADTLTLLLEGIARIVETHQPIVETYYGPGRLHTLLAHLQKECDKQAQKIVDKFIQQRDYNNKFQVVQSNMMRGMTTDKIEPRDLDPVLCEVTLMNSRAELYFRFLRRRIVADFEVADAMADEAVIQEHQQSLEQLLKNCQLSRTMQELIGYYIPMEEYYMRESVNKAVAMDTAEVGQLSSSVVDDVFYIVKKCISRALTSSSSDCVCAMINHATSVLETDFREVLVCKLRAGYPVSALQDLQRGVSSAVSLMQSSLQQGKITNLTQTLGIESQEQAKSAYLVTLNNVEVCSENISTLKKNLESDCAKLFSQGASSDHAKEKIDSCLSDLVNTSSKFKDLLQEGLQELNNTAIRPQVKPWISSFLSVSHNIEEEEFSEYEANDPFVQQLIVQLEQLMAEFKVGLSPVIYDTLTSLMTSLIAMEMEKTVFKCTFSRLGGLQFDKELRALVAYLSSVTSWTIRDKFARLTQMATILNLERVSEILDYWGPNSGPLTWRLTPAEVRQVLALRVDFRSEDIKRLRL", "length": 781 }, "evidence": [ { "id": "Q3MHG0", "url": "https://omabrowser.org/oma/group/Q3MHG0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q55FT5-1", "protein_name": "Conserved oligomeric Golgi complex subunit 4", "gene_name": "cog4", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDELIVDFNNLDSNLSIDDAKKYLQNLISRDKAIEINLKQHIKLKDDLEIQMESFDNEIPEYLTLSLKKSNELNNRISSTCQLAENLSSKVKKLDNIRERIKDTLKKVDDIIDLKNCIEGVQISIEKEDYEGAAFHINRYLSIDKSVLEDNSSEKLSIAEKKLLSMIESKYQQSLQDNDQKQVLRFCILYVPLEKPLEGIDKYCNYLKNQSKKLDAMITHYRNYIQSPKTIKPISAVSVITKIFEHFAAIIEDDLPIIKSEFGVLHCPHFILNITQQCDYYSSKVYDSFNDQFQTNKNVNDILVYKQQLEKSQQSIQDSGSGSGGGGGKVSEKIDPRNFAQFLDETSMISKATKFYEKYLIRKEHLIKSDIYQYYSKLEKEKIEKLNSIKSLIITNSRNQQLQQLPQPQQLQQQQQYQQQLQTQENKENELLKKLTQEKDKQMKQTIYSNVTKQKMNQLLGNYILLEEYFMVESVNKAIQMDSLQSLDFENNINSSNSNSSSVSGSGIGGSNTLSSSNSQQSQQSTDNTMIDFIFFVLQKSLQRAIDSHSIQTLNVICNRLCRILSQTRDNLKRIFREYIIRSSSKSVMDYQSSLQVLNNLETSSEYIIRLKKEFDSKCLKIYPIYKLDEKSKDLESSSTSSTSIEQQQQQQQQQQQQQQQQQQQQQQQQQQQEQQQENEFESNLKDDIIIIRNLLNLELKKKQENDRDQVNILSNEFLNCSKSFNKILQEEIESLFKSVQPRLKNVLNQFTLVNYEINQLEYDNNDINDPFVLQFTLEISHFFKPFQEHLSNTNYDYLVHQTIQFILKKIEGITIQQKKFTLLGGLQFGKDLRAISTYFTKISQSTIRDKFSKLNQISSFLILESISEVEDHWNENRNSPTWKLSSSEVQKILMTRIDFNHDQILKLKFN", "length": 911 }, "evidence": [ { "id": "Q3MHG0", "url": "https://omabrowser.org/oma/group/Q3MHG0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8L838-1", "protein_name": "Conserved oligomeric Golgi complex subunit 4", "gene_name": "COG4", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MPEIEQDDAAAETVDSSTVKFGTPEALEYVRSLTDVGAMTRLLHECIAYQRSLDSDLDTLLSQRTELDRNLVQLQRSAEILDIVKADADHMLGNVRSTCDLADQVSGKVRELDLAQSRVNVTLSRIDAIVERGNCIEGVKTALESEDYESAAKFVQRFLQIDLQYKDSGSDQSEQLHASKEQLEGIAKKKLLAAIDQRDHPTILRFVRLYSPLGMETEGLQLYVGYLKKVIALRGRMEYENVVELMEQGLGQVNFVGCLTNLFKDIVMAIEENDEILRGLCGEDGVAYAICELQEECDLRGSLILKKYMDFRKLAILASDINNSPNLNILPGGASEGPDPREVELYVEEILSLMQLGEDYTEFMVSKIKSLTSVDPELLPTATKAFRNKSFSKAIQDVTRYYVILEGFFMVENVRKAIRIDEHVPDSLTTSMVDDVFYVLQSCLRRAISTSNISSVIAVLSYAGSLLGNDYHEALQQKIREPNLGARLFLGGIGVENTGTEIATALNNMDVSCEYILKLKHEIEEQCTEVFPAPADRERIKSCLSELGELSSTFKQLLNSGMEQLVATVTPRIRPVLDTVATISYELTETEYAENEVNDPWVQRLLHSVETNAAWLQPLMTSNNYDSFLHLIIDFIVKRLEVIMMQKRFSQLGGLQLDRDTRALVSHFSGMTQRTVRDKFARLTQMATILNLEKVSEILDFWGENSGPMTWRLTPAEVRRVLGLRVEFKPESIAALKL", "length": 738 }, "evidence": [ { "id": "Q3MHG0", "url": "https://omabrowser.org/oma/group/Q3MHG0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q8R1U1-1", "protein_name": "Conserved oligomeric Golgi complex subunit 4", "gene_name": "Cog4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEVESPLKLSGAPPPPEGVGGGHCSEISTELIRSLTELQELEAVYERLCGEEKAVEKELDALLEQQNTIESKMVTLHRMGPSLQLIEGDAKQLAGMITFTCSLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRNEDYEQAAAHIHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEDGLSKFSEYLCKQVASKAEENLLLVLGSDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLFTLIKYLQVECDTQVEKVVNKFIKQRDYHQQFRLVQSNLMRNSATEKIEPRELDPVLTEVTLMNARSELYLRFLRKRISADFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGFYITMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSNIDCLCAMINLATRELEADFRDVLCNKLRMGFPATTLQDIQRGVTSAVNIMHSSLQQGKFDTKGIESTDEAKLSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLAELNSSAVKPQVQPWINTFLSVSHSIEEEEFNDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGANSGPLTWRLTPAEVRQVLALRIDFRNEDIKRLRL", "length": 785 }, "evidence": [ { "id": "Q3MHG0", "url": "https://omabrowser.org/oma/group/Q3MHG0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q95TN4-1", "protein_name": "Conserved oligomeric Golgi complex subunit 4", "gene_name": "Cog4", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSVLEQLGALDIGTNEQVDETLQRIADEEAKVNEKLESLLAKQCQIEAKMSGIGRSLSLLHTVDSDSNKLNDQIVNTAQLAESVSAKVRRLDLARCRASECQQRVHDLIDLHLCSQGVVKAIGEEDYEKSATHIARFLAMDQQLLRRTADDVQGSITSVSDAVKTLEDATEKTRVLIAKRFDEAVKADDLASVERFFKIFPLVGCHRTGIEKFSLYICQKLANKAQKELRNAQDIAKAESRLQLAYADRLTAILENFARVVEVNQPIIEAFYGQASSSLIDMVSILQHECDTEVKNLLMEFNKNRQIQYRSKQVNESTQRSAGGGNLGSNSIQALGHYRKPSGGSVDKLNPKEIDAIIAEITVMHARVELYFRFMRRRLQVHVETCVPEKEQFDIMERYEKIMKNSDLRRQMQEILSTYLLLERYFMEESVLKAIGLDTYESGQQCSSMVDDVFFILRKSIRRALTTQSINGTCAVINNVAACLDGDFVNALKAPLKSGYPSGYIDLAQAYNAIQTSLQQGKLHSSDADRGRANFLVQLNNADISTEYIETLCQTMEQEIAGTFPQTTQVERQMLDSCLTELKAVRDALKATVDFGMQQLRSSVIKPRLNPWINQFLNYSHNLNEEELAAYEAGETFVQFFIVQLDGLLNSFKNSLSPRNYDALVSILATEVTIQLERAIKKISFNRLGGLVLDQEVRALGSYLTGATSWSVRDKMTRISQIATLLNLDKITELSEYWNPENNKEMSSWHLTPNEVRTFLTLRNDFRIEDIKRLQL", "length": 776 }, "evidence": [ { "id": "Q3MHG0", "url": "https://omabrowser.org/oma/group/Q3MHG0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9H9E3-1", "protein_name": "Conserved oligomeric Golgi complex subunit 4", "gene_name": "COG4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADLDSPPKLSGVQQPSEGVGGGRCSEISAELIRSLTELQELEAVYERLCGEEKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEEGLRKFSEYLCKQVASKAEENLLMVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQFRHVQNNLMRNSTTEKIEPRELDPILTEVTLMNARSELYLRFLKKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYVTMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFRDVLCNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQGKFDTKGIESTDEAKMSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLTELNSTAIKPQVQPWINSFFSVSHNIEEEEFNDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGPNSGPLTWRLTPAEVRQVLALRIDFRSEDIKRLRL", "length": 785 }, "evidence": [ { "id": "Q3MHG0", "url": "https://omabrowser.org/oma/group/Q3MHG0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG0", "url": "https://www.uniprot.org/uniprotkb/Q3MHG0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG0", "url": "https://www.uniprot.org/uniprotkb/Q3MHG0" } ], "pmid": "" }, { "name": "Golgi transport complex", "id": "GO:0017119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017119", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG0", "url": "https://www.uniprot.org/uniprotkb/Q3MHG0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG0", "url": "https://www.uniprot.org/uniprotkb/Q3MHG0" } ], "pmid": "" }, { "name": "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "id": "GO:0006890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006890", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG0", "url": "https://www.uniprot.org/uniprotkb/Q3MHG0" } ], "pmid": "" }, { "name": "Golgi organization", "id": "GO:0007030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007030", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG0", "url": "https://www.uniprot.org/uniprotkb/Q3MHG0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 341, "end_pos": 343, "annotation": "n_glycosylation_sequon" }, { "start_pos": 557, "end_pos": 559, "annotation": "n_glycosylation_sequon" }, { "start_pos": 612, "end_pos": 614, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHG0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 785, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHG0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHG0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 6 ], "sequon_annotation_sites": [ { "start_pos": 107, "end_pos": 109 }, { "start_pos": 341, "end_pos": 343 }, { "start_pos": 557, "end_pos": 559 }, { "start_pos": 612, "end_pos": 614 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHG7-1", "uniprot_ac": "Q3MHG7", "uniprot_id": "URIC_BOVIN", "mass": { "chemical_mass": 35124.0, "monoisotopic_mass": 35124.0 }, "refseq": { "ac": "NP_001069116", "name": "uricase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069116" }, "gene_names": [ { "name": "UOX", "type": "recommended", "evidence": [ { "id": "Q3MHG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7" } ] }, { "name": "UOX", "type": "synonym", "evidence": [ { "id": "NP_001069116", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069116" } ] } ], "protein_names": [ { "name": "Uricase", "type": "recommended", "evidence": [ { "id": "Q3MHG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7/entry#names_and_taxonomy" } ] }, { "name": "1.7.3.3", "type": "synonym", "evidence": [ { "id": "Q3MHG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7/entry#names_and_taxonomy" } ] }, { "name": "Urate oxidase", "type": "synonym", "evidence": [ { "id": "Q3MHG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7/entry#names_and_taxonomy" } ] }, { "name": "uricase", "type": "synonym", "evidence": [ { "id": "NP_001069116", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069116" } ] } ], "function": [ { "annotation": "Activation energy requirement for uric acid hydrolysis by uricase & inactivation of enzyme were 11.6 & 14.5 kJ/M respectively. Both enthalpy & entropy of activation for uricase activity were lower than those reported for some thermostable enzymes.", "evidence": [ { "database": "RefSeq", "id": "NP_001069116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069116" }, { "database": "PubMed", "id": "16712512", "url": "https://glygen.org/publication/PubMed/16712512" } ] }, { "annotation": "Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG7", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHG7", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UOX", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7", "locus": { "chromosome": "3", "start_pos": 59736408, "end_pos": 59637401, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024255", "url": "https://www.ensembl.org/id/ENSBTAG00000024255" } ] } } ], "crossref": [ { "id": "Q3MHG7", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHG7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00445", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00445", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514113", "url": "https://www.ncbi.nlm.nih.gov/gene/514113", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002042", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002042", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019842", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019842", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514113", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514113", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3MHG7", "url": "https://www.orthodb.org/?gene=Q3MHG7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42874", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42874", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42874:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42874:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01014", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01014", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069116", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "21368", "url": "https://www.rhea-db.org/rhea/21368", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3MHG7", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHG7-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAHYHNDYQKNDEVEFVRTGYGKDMVKVLHIQRDGKYHSIKEVATSVQLTLNSRREYLHGDNSDIIPTDTIKNTVQVLAKFKGIKSIETFAMNICEHFLSSFNHVIRVQVYVEEVPWKRFEKNGVKHVHAFIHTPTGTHFCEVEQLRSGPPVIHSGIKDLKVLKTTQSGFEGFLKDQFTTLPEVKDRCFATQVYCKWRYHQGRDVDFEATWEAVRGIVLKKFAGPYDKGEYSPSVQKTLYDIQVLSLSQLPEIEDMEISLPNIHYFNIDMSKMGLINKEEVLLPLDNPYGRITGTVKRKLTSRL", "length": 304, "header": "sp|Q3MHG7-1|URIC_BOVIN Isoform 1 of Uricase OS=Bos taurus OX=9913 GN=UOX PE=2 SV=3 CANONICAL=Q3MHG7-1" }, "isoforms": [ { "isoform_ac": "Q3MHG7-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7/entry#Q3MHG7-1", "sequence": { "sequence": "MAHYHNDYQKNDEVEFVRTGYGKDMVKVLHIQRDGKYHSIKEVATSVQLTLNSRREYLHGDNSDIIPTDTIKNTVQVLAKFKGIKSIETFAMNICEHFLSSFNHVIRVQVYVEEVPWKRFEKNGVKHVHAFIHTPTGTHFCEVEQLRSGPPVIHSGIKDLKVLKTTQSGFEGFLKDQFTTLPEVKDRCFATQVYCKWRYHQGRDVDFEATWEAVRGIVLKKFAGPYDKGEYSPSVQKTLYDIQVLSLSQLPEIEDMEISLPNIHYFNIDMSKMGLINKEEVLLPLDNPYGRITGTVKRKLTSRL", "length": 304, "header": "sp|Q3MHG7-1|URIC_BOVIN Isoform 1 of Uricase OS=Bos taurus OX=9913 GN=UOX PE=2 SV=3 CANONICAL=Q3MHG7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 232, "end_pos": 232, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG7", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7" } ], "site_lbl": "Ser232" }, { "start_pos": 289, "end_pos": 289, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG7", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7" } ], "site_lbl": "Tyr289" }, { "start_pos": 39, "end_pos": 39, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG7", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7" } ], "site_lbl": "Ser39" }, { "start_pos": 63, "end_pos": 63, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG7", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7" } ], "site_lbl": "Ser63" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Purification, and properties of a bovine uricase.", "journal": "Protein and peptide letters", "date": "2006", "authors": "Rajoka Muhammad Ibrahim, Rehman Khalil-Ur-, Mehraj Munazza, Akhtar Muhammad Waheed, Zia Muhammad Anjum", "evidence": [ { "database": "RefSeq", "id": "NP_001069116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069116" } ], "reference": [ { "type": "PubMed", "id": "16712512", "url": "https://glygen.org/publication/PubMed/16712512" } ] } ], "pathway": [ { "id": "bta:514113", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514113", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "purine nucleobase catabolic process", "id": "GO:0006145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006145", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG7", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7" } ], "pmid": "" }, { "name": "urate catabolic process", "id": "GO:0019628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019628", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG7", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG7", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "urate oxidase activity", "id": "GO:0004846", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004846", "evidence": [ { "database": "UniProtKB", "id": "Q3MHG7", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21368", "name": "", "equation": "urate + O2 + H2O = 5-hydroxyisourate + H2O2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1NMP3-1", "Q3MHG7-1" ], "evidence": [ { "id": "21368", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21368" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1NMP3", "gene_name": "UOX", "activity": [ { "ec_number": "1.7.3.3", "activity": "urate + O2 + H2O = 5-hydroxyisourate + H2O2.", "evidence": [ { "id": "A0A3Q1NMP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMP3" } ] }, { "ec_number": "1.7.3.3", "activity": "", "evidence": [ { "id": "A0A3Q1NMP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMP3" } ] } ] }, { "uniprot_ac": "Q3MHG7", "gene_name": "UOX", "activity": [ { "ec_number": "1.7.3.3", "activity": "urate + O2 + H2O = 5-hydroxyisourate + H2O2.", "evidence": [ { "id": "Q3MHG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7" } ] }, { "ec_number": "1.7.3.3", "activity": "", "evidence": [ { "id": "Q3MHG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHG7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 304, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHG7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHG7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3MHG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHG7" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Microbody targeting signal", "eco_id": "ECO_0000255", "start_pos": 302, "end_pos": 304, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.7.3.3", "ec_name": "urate + O2 + H2O = 5-hydroxyisourate + H2O2.", "evidence": [ { "id": "1.7.3.3", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.3.3" }, { "id": "1.7.3.3", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.7.3.3" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 39, 63, 232, 289 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3MHH5-1", "uniprot_ac": "Q3MHH5", "uniprot_id": "CCND3_BOVIN", "mass": { "chemical_mass": 32436.0, "monoisotopic_mass": 32436.0 }, "refseq": { "ac": "NP_001029881", "name": "G1/S-specific cyclin-D3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029881" }, "gene_names": [ { "name": "CCND3", "type": "recommended", "evidence": [ { "id": "Q3MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5" } ] }, { "name": "CCND3", "type": "synonym", "evidence": [ { "id": "NP_001029881", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029881" } ] } ], "protein_names": [ { "name": "G1/S-specific cyclin-D3", "type": "recommended", "evidence": [ { "id": "Q3MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5/entry#names_and_taxonomy" } ] }, { "name": "G1/S-specific cyclin-D3", "type": "synonym", "evidence": [ { "id": "NP_001029881", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029881" } ] } ], "function": [ { "annotation": "Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Shows transcriptional coactivator activity with ATF5 independently of CDK4.", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH5", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5#function" }, { "database": "UniProtKB", "id": "P30281", "url": "https://www.uniprot.org/uniprotkb/P30281#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHH5", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCND3", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5", "locus": { "chromosome": "23", "start_pos": 15698661, "end_pos": 15705587, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010106", "url": "https://www.ensembl.org/id/ENSBTAG00000010106" } ] } } ], "crossref": [ { "id": "Q3MHH5", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHH5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd20575", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20575", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540547", "url": "https://www.ncbi.nlm.nih.gov/gene/540547", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004367", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004367", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006671", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006671", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048258", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048258", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540547", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540547", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3MHH5", "url": "https://www.orthodb.org/?gene=Q3MHH5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10177", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10177", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00134", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00134", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02984", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02984", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029881", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3MHH5", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHH5-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHSVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLALILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSTSGDELTELLAGIAGTEVDCLRACQEQIEAALRESLREAAQTSPSPAPKAPRGSSSQGPSQTSTPTDVTAIHL", "length": 292, "header": "sp|Q3MHH5-1|CCND3_BOVIN Isoform 1 of G1/S-specific cyclin-D3 OS=Bos taurus OX=9913 GN=CCND3 PE=2 SV=1 CANONICAL=Q3MHH5-1" }, "isoforms": [ { "isoform_ac": "Q3MHH5-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5/entry#Q3MHH5-1", "sequence": { "sequence": "MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHSVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLALILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSTSGDELTELLAGIAGTEVDCLRACQEQIEAALRESLREAAQTSPSPAPKAPRGSSSQGPSQTSTPTDVTAIHL", "length": 292, "header": "sp|Q3MHH5-1|CCND3_BOVIN Isoform 1 of G1/S-specific cyclin-D3 OS=Bos taurus OX=9913 GN=CCND3 PE=2 SV=1 CANONICAL=Q3MHH5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 264, "end_pos": 264, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH5", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5" } ], "site_lbl": "Ser264" }, { "start_pos": 279, "end_pos": 279, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH5", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5" } ], "site_lbl": "Ser279" }, { "start_pos": 283, "end_pos": 283, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH5", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5" } ], "site_lbl": "Thr283" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540547", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540547", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH5", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH5", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5" } ], "pmid": "" }, { "name": "microtubule organizing center", "id": "GO:0005815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005815", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH5", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5" } ], "pmid": "" }, { "name": "cyclin-dependent protein kinase holoenzyme complex", "id": "GO:0000307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000307", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH5", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH5", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH5", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5" } ], "pmid": "" }, { "name": "G1/S transition of mitotic cell cycle", "id": "GO:0000082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000082", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH5", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5" } ], "pmid": "" }, { "name": "positive regulation of G1/S transition of mitotic cell cycle", "id": "GO:1900087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900087", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH5", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH5", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5" } ], "pmid": "" }, { "name": "cyclin-dependent protein serine/threonine kinase regulator activity", "id": "GO:0016538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016538", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH5", "url": "https://www.uniprot.org/uniprotkb/Q3MHH5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHH5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 292, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHH5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHH5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 264, 279, 283 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHH7-1", "uniprot_ac": "Q3MHH7", "uniprot_id": "PALMD_BOVIN", "mass": { "chemical_mass": 62380.0, "monoisotopic_mass": 62380.0 }, "refseq": { "ac": "NP_001030251", "name": "palmdelphin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030251" }, "gene_names": [ { "name": "PALMD", "type": "recommended", "evidence": [ { "id": "Q3MHH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHH7" } ] }, { "name": "PALMD", "type": "synonym", "evidence": [ { "id": "NP_001030251", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030251" } ] } ], "protein_names": [ { "name": "Palmdelphin", "type": "recommended", "evidence": [ { "id": "Q3MHH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHH7/entry#names_and_taxonomy" } ] }, { "name": "palmdelphin", "type": "synonym", "evidence": [ { "id": "NP_001030251", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030251" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHH7", "url": "https://www.uniprot.org/uniprotkb/Q3MHH7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PALMD", "url": "https://www.uniprot.org/uniprotkb/Q3MHH7", "locus": { "chromosome": "3", "start_pos": 43536431, "end_pos": 43596104, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017655", "url": "https://www.ensembl.org/id/ENSBTAG00000017655" } ] } } ], "crossref": [ { "id": "Q3MHH7", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHH7", "database": "AlphaFoldDB", "categories": [] }, { "id": "509823", "url": "https://www.ncbi.nlm.nih.gov/gene/509823", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509823", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509823", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3MHH7", "url": "https://www.orthodb.org/?gene=Q3MHH7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46881", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46881", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46881:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46881:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03285", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03285", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030251", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3MHH7", "url": "https://www.uniprot.org/uniprotkb/Q3MHH7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHH7-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHH7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEAELVKERLQAITDKRKIQEEISQKRLKIEEEKLKHQHLKKKALREKWLLDGISSGKEQEEMKKQNQQDQHQIQVLEQSILRLEKEIQDLEKAELQISTNEEAILKKLKSVERTTEDIIRSVKVEKEETSGESVEDIYANIPDLPKSYIPSRLRKERNEGIEDDEQNRKALYAMEIKVEKDLKTGESTVLSSIPLPSDDFKGTGIKVYDDGQKSVYAVSSNHSAAYNGTDGLAPVEVEELLRQASERNSKSPTEYHEPVYANPFCRPTTPQREKVTPGPNFQERVKIKANGLGNDVNGSIHNIDNGLAEERGNNVNHISPARPIPHPRSMIQQAEEMPHIQQERLMTPWEEPNVMQDKYTPSPKSGLSPSRALVEKSERQSSSPPCQEDEKDIRYNIVHSLPSDLDEKEPVTMIFMGYQQAEDNEEEKKLLTGYDGIIHAELVVIDDEEEGEGEAEKPAYHPIAPHSQVFQPAKPTPLPRKRAEVNPHENTNHKSPHKNSISLKEQEESLGSPIHHSPLDVQIAGDGTEDPSLTALRMRMAKLGKKVI", "length": 550, "header": "sp|Q3MHH7-1|PALMD_BOVIN Isoform 1 of Palmdelphin OS=Bos taurus OX=9913 GN=PALMD PE=2 SV=1 CANONICAL=Q3MHH7-1" }, "isoforms": [ { "isoform_ac": "Q3MHH7-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHH7/entry#Q3MHH7-1", "sequence": { "sequence": "MEEAELVKERLQAITDKRKIQEEISQKRLKIEEEKLKHQHLKKKALREKWLLDGISSGKEQEEMKKQNQQDQHQIQVLEQSILRLEKEIQDLEKAELQISTNEEAILKKLKSVERTTEDIIRSVKVEKEETSGESVEDIYANIPDLPKSYIPSRLRKERNEGIEDDEQNRKALYAMEIKVEKDLKTGESTVLSSIPLPSDDFKGTGIKVYDDGQKSVYAVSSNHSAAYNGTDGLAPVEVEELLRQASERNSKSPTEYHEPVYANPFCRPTTPQREKVTPGPNFQERVKIKANGLGNDVNGSIHNIDNGLAEERGNNVNHISPARPIPHPRSMIQQAEEMPHIQQERLMTPWEEPNVMQDKYTPSPKSGLSPSRALVEKSERQSSSPPCQEDEKDIRYNIVHSLPSDLDEKEPVTMIFMGYQQAEDNEEEKKLLTGYDGIIHAELVVIDDEEEGEGEAEKPAYHPIAPHSQVFQPAKPTPLPRKRAEVNPHENTNHKSPHKNSISLKEQEESLGSPIHHSPLDVQIAGDGTEDPSLTALRMRMAKLGKKVI", "length": 550, "header": "sp|Q3MHH7-1|PALMD_BOVIN Isoform 1 of Palmdelphin OS=Bos taurus OX=9913 GN=PALMD PE=2 SV=1 CANONICAL=Q3MHH7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 135, "end_pos": 135, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHH7", "url": "https://www.uniprot.org/uniprotkb/Q3MHH7" 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"Genetics, selection, evolution : GSE", "date": "2016-10-19", "authors": "Olsen Hanne Gro, Knutsen Tim Martin, Lewandowska-Sabat Anna M, Grove Harald, Nome Torfinn, Svendsen Morten, Arnyasi Mariann, Sodeland Marte, Sundsaasen Kristil K, Dahl Sandra Rinne, Heringstad Bj\u00f8rg, Hansen Hanne H, Olsaker Ingrid, Kent Matthew Peter, Lien Sigbj\u00f8rn", "evidence": [ { "database": "RefSeq", "id": "NP_001030457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030457" } ], "reference": [ { "type": "PubMed", "id": "27760518", "url": "https://glygen.org/publication/PubMed/27760518" } ] }, { "title": "A 12 kb multi-allelic copy number variation encompassing a GC gene enhancer is associated with mastitis resistance in dairy cattle.", "journal": "PLoS genetics", "date": "2021-07", "authors": "Lee Young-Lim, Takeda Haruko, Costa Monteiro Moreira Gabriel, Karim Latifa, Mullaart Erik, Coppieters Wouter, , Appeltant Ruth, Veerkamp Roel F, Groenen Martien A M, Georges Michel, Bosse Mirte, Druet 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"uniprot_canonical_ac": "Q3MHP0-1", "uniprot_ac": "Q3MHP0", "uniprot_id": "RNPC3_BOVIN", "mass": { "chemical_mass": 58510.0, "monoisotopic_mass": 58510.0 }, "refseq": { "ac": "NP_001070585", "name": "RNA-binding region-containing protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070585" }, "gene_names": [ { "name": "RNPC3", "type": "recommended", "evidence": [ { "id": "Q3MHP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP0" } ] }, { "name": "RBM40", "type": "synonym", "evidence": [ { "id": "Q3MHP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP0" } ] }, { "name": "RNPC3", "type": "synonym", "evidence": [ { "id": "NP_001070585", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070585" } ] } ], "protein_names": [ { "name": "RNA-binding region-containing protein 3", "type": "recommended", "evidence": [ { "id": "Q3MHP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP0/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding motif protein 40", "type": "synonym", "evidence": [ { "id": "NP_001070585", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070585" }, { "id": "Q3MHP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP0/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding protein 40", "type": "synonym", "evidence": [ { "id": "NP_001070585", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070585" }, { "id": "Q3MHP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP0/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding region-containing protein 3", "type": "synonym", "evidence": [ { "id": "NP_001070585", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070585" } ] } ], "function": [ { "annotation": "Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP0", "url": "https://www.uniprot.org/uniprotkb/Q3MHP0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHP0", "url": "https://www.uniprot.org/uniprotkb/Q3MHP0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RNPC3", "url": "https://www.uniprot.org/uniprotkb/Q3MHP0", "locus": { "chromosome": "3", "start_pos": 39855791, "end_pos": 39883179, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019091", "url": "https://www.ensembl.org/id/ENSBTAG00000019091" } ] } } ], "crossref": [ { "id": "Q3MHP0", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHP0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12238", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12238", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12239", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12239", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "768060", "url": "https://www.ncbi.nlm.nih.gov/gene/768060", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034147", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034147", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:768060", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768060", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3MHP0", "url": "https://www.orthodb.org/?gene=Q3MHP0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16105", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16105", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16105:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16105:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070585", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3MHP0", "url": "https://www.uniprot.org/uniprotkb/Q3MHP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHP0-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHP0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPEQPLPMSRGCQNSSSLSPPRGDRTLLVRHLPAELTAEEKEDLLKYFGAQSVRDLSDKGRLKHTAFATFPNEKTAVKALTRLHQLKLLGHTLVVEFAKEQDRVHSPCPSLGTEKKKRSDDPVEDDKEKKELDCLTIENGIAPNHGLTFPLNSCLKYMYPPPSSTILANIVNALASVPKFYVQVLHLMNKMNLPTPFGPITTRPPMYEDYMPLHAPLPPTSPQPPEEPPLPDEDEELSSKESEYESSDDEDRQRMTKLMELANLQPKRPKPIKQRHVRKKRKIKDMLNIPSSASHSLHPVLLPSDVFDQPQPVGNKKIEFHISTDMQVAFKKDLEKQQNCEEENSDLPATEADASNIGFGKIFPQPNLNITEEIKDDSDEMPSECISRRELEKGRISREEMETLSVFRSYEPGEPNCRIYVKNLAKHVQEKDLKFIFGRYVDFSSETQRIMFDIRLMKEGRMKGQAFIGLPNEKAAAKALKEANGYVLFGKPMVVQFARSARPKQDSKEGKRKC", "length": 516, "header": "sp|Q3MHP0-1|RNPC3_BOVIN Isoform 1 of RNA-binding region-containing protein 3 OS=Bos taurus OX=9913 GN=RNPC3 PE=2 SV=1 CANONICAL=Q3MHP0-1" }, "isoforms": [ { "isoform_ac": "Q3MHP0-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHP0/entry#Q3MHP0-1", "sequence": { "sequence": "MAAPEQPLPMSRGCQNSSSLSPPRGDRTLLVRHLPAELTAEEKEDLLKYFGAQSVRDLSDKGRLKHTAFATFPNEKTAVKALTRLHQLKLLGHTLVVEFAKEQDRVHSPCPSLGTEKKKRSDDPVEDDKEKKELDCLTIENGIAPNHGLTFPLNSCLKYMYPPPSSTILANIVNALASVPKFYVQVLHLMNKMNLPTPFGPITTRPPMYEDYMPLHAPLPPTSPQPPEEPPLPDEDEELSSKESEYESSDDEDRQRMTKLMELANLQPKRPKPIKQRHVRKKRKIKDMLNIPSSASHSLHPVLLPSDVFDQPQPVGNKKIEFHISTDMQVAFKKDLEKQQNCEEENSDLPATEADASNIGFGKIFPQPNLNITEEIKDDSDEMPSECISRRELEKGRISREEMETLSVFRSYEPGEPNCRIYVKNLAKHVQEKDLKFIFGRYVDFSSETQRIMFDIRLMKEGRMKGQAFIGLPNEKAAAKALKEANGYVLFGKPMVVQFARSARPKQDSKEGKRKC", "length": 516, "header": "sp|Q3MHP0-1|RNPC3_BOVIN Isoform 1 of RNA-binding region-containing protein 3 OS=Bos taurus OX=9913 GN=RNPC3 PE=2 SV=1 CANONICAL=Q3MHP0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 108, "end_pos": 108, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP0", "url": "https://www.uniprot.org/uniprotkb/Q3MHP0" } ], "site_lbl": "Ser108" }, { "start_pos": 21, "end_pos": 21, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP0", "url": "https://www.uniprot.org/uniprotkb/Q3MHP0" } ], "site_lbl": "Ser21" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:768060", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768060", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "pre-mRNA intronic binding", "id": "GO:0097157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097157", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP0", "url": "https://www.uniprot.org/uniprotkb/Q3MHP0" } ], "pmid": "" }, { "name": "U12 snRNA binding", "id": "GO:0030626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030626", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP0", "url": "https://www.uniprot.org/uniprotkb/Q3MHP0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP0", "url": "https://www.uniprot.org/uniprotkb/Q3MHP0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "U12-type spliceosomal complex", "id": "GO:0005689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005689", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP0", "url": "https://www.uniprot.org/uniprotkb/Q3MHP0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" }, { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHP0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 516, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHP0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHP0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3MHP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP0" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM 1", "eco_id": "ECO_0000255", "start_pos": 27, "end_pos": 102, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3MHP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP0" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM 2", "eco_id": "ECO_0000255", "start_pos": 419, "end_pos": 502, "start_aa": "Cys", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 21, 108 ], "sequon_annotation_sites": [ { "start_pos": 16, "end_pos": 18 }, { "start_pos": 371, "end_pos": 373 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHP3-1", "uniprot_ac": "Q3MHP3", "uniprot_id": "S10AE_BOVIN", "mass": { "chemical_mass": 11410.0, "monoisotopic_mass": 11410.0 }, "refseq": { "ac": "NP_001073102", "name": "protein S100-A14", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073102" }, "gene_names": [ { "name": "S100A14", "type": "recommended", "evidence": [ { "id": "Q3MHP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3" } ] }, { "name": "S100A14", "type": "synonym", "evidence": [ { "id": "NP_001073102", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073102" } ] } ], "protein_names": [ { "name": "Protein S100-A14", "type": "recommended", "evidence": [ { "id": "Q3MHP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3/entry#names_and_taxonomy" } ] }, { "name": "S100 calcium-binding protein A14", "type": "synonym", "evidence": [ { "id": "Q3MHP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3/entry#names_and_taxonomy" } ] }, { "name": "protein S100-A14", "type": "synonym", "evidence": [ { "id": "NP_001073102", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073102" } ] } ], "function": [ { "annotation": "Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP3", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHP3", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "S100A14", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3", "locus": { "chromosome": "3", "start_pos": 16768597, "end_pos": 16766542, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021377", "url": "https://www.ensembl.org/id/ENSBTAG00000021377" } ] } } ], "crossref": [ { "id": "Q3MHP3", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHP3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021377", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021377", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05022", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05022", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "618250", "url": "https://www.ncbi.nlm.nih.gov/gene/618250", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618250", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618250", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NFHQYSA", "url": "https://omabrowser.org/oma/group/NFHQYSA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3MHP3", "url": "https://www.orthodb.org/?gene=Q3MHP3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11639", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11639", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11639:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11639:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073102", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3MHP3", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHP3-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGQCRSANAEDAQELSDVERAIETLIKNFHQYSVEGGKETLTPSELRDLVTQQLPHLMPSNCGLEEKIANLGNCNDSKLEFGSFWELIGEAAKSVKLENAVQGS", "length": 104, "header": "sp|Q3MHP3-1|S10AE_BOVIN Isoform 1 of Protein S100-A14 OS=Bos taurus OX=9913 GN=S100A14 PE=3 SV=1 CANONICAL=Q3MHP3-1" }, "isoforms": [ { "isoform_ac": "Q3MHP3-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3/entry#Q3MHP3-1", "sequence": { "sequence": "MGQCRSANAEDAQELSDVERAIETLIKNFHQYSVEGGKETLTPSELRDLVTQQLPHLMPSNCGLEEKIANLGNCNDSKLEFGSFWELIGEAAKSVKLENAVQGS", "length": 104, "header": "sp|Q3MHP3-1|S10AE_BOVIN Isoform 1 of Protein S100-A14 OS=Bos taurus OX=9913 GN=S100A14 PE=3 SV=1 CANONICAL=Q3MHP3-1" }, "locus": { "chromosome": "3", "start_pos": 16767987, "end_pos": 16767017, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028498.5", "url": "https://www.ensembl.org/id/ENSBTAT00000028498.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028498.3", "url": "https://www.ensembl.org/id/ENSBTAP00000028498.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618250", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618250", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6A7N5-1", "protein_name": "Protein S100-A14", "gene_name": "S100a14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGQCRSANAEDAQELSDVERAIETLIKNFHNYSVEGKKETLTPAELRDLVTQQLPHLMPSNCGLEEKIANLGNCNDSKLEFGSFWELIGEAAKSVKMERPVARS", "length": 104 }, "evidence": [ { "id": "Q3MHP3", "url": "https://omabrowser.org/oma/group/Q3MHP3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SFV3-1", "protein_name": "Protein S100-A14", "gene_name": "S100A14", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGQCRSANAEDAQEFSDVERAIETLIKNFHQYSVEGGKETLTPSELRDLVTQQLPHLMPSNCGLEEKIANLGSCNDSKLEFGSFWELIGEAAKSVKLESPVRGS", "length": 104 }, "evidence": [ { "id": "Q3MHP3", "url": "https://omabrowser.org/oma/group/Q3MHP3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9D2Q8-1", "protein_name": "Protein S100-A14", "gene_name": "S100a14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGQCRSANAEDAQEFSDVERAIETLIKNFHKYSVAGKKETLTPAELRDLVTQQLPHLMPSNCGLEEKIANLGNCNDSKLEFGSFWELIGEAAKSVKMERPVTRS", "length": 104 }, "evidence": [ { "id": "Q3MHP3", "url": "https://omabrowser.org/oma/group/Q3MHP3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HCY8-1", "protein_name": "Protein S100-A14", "gene_name": "S100A14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGQCRSANAEDAQEFSDVERAIETLIKNFHQYSVEGGKETLTPSELRDLVTQQLPHLMPSNCGLEEKIANLGSCNDSKLEFRSFWELIGEAAKSVKLERPVRGH", "length": 104 }, "evidence": [ { "id": "Q3MHP3", "url": "https://omabrowser.org/oma/group/Q3MHP3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP3", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP3", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP3", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "response to lipopolysaccharide", "id": "GO:0032496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032496", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP3", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3" } ], "pmid": "" }, { "name": "positive regulation of monocyte chemotaxis", "id": "GO:0090026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090026", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP3", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP3", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3" } ], "pmid": "" }, { "name": "defense response to bacterium", "id": "GO:0042742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP3", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3" } ], "pmid": "" }, { "name": "toll-like receptor 4 signaling pathway", "id": "GO:0034142", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034142", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP3", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3" } ], "pmid": "" }, { "name": "positive regulation of granulocyte chemotaxis", "id": "GO:0071624", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071624", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP3", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "calcium-dependent protein binding", "id": "GO:0048306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048306", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP3", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP3", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3" } ], "pmid": "" }, { "name": "chemokine receptor binding", "id": "GO:0042379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042379", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP3", "url": "https://www.uniprot.org/uniprotkb/Q3MHP3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHP3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 104, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHP3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHP3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 75, "end_pos": 77 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHP9-1", "uniprot_ac": "Q3MHP9", "uniprot_id": "TACT_BOVIN", "mass": { "chemical_mass": 63395.0, "monoisotopic_mass": 63395.0 }, "refseq": { "ac": "NP_001030244", "name": "T-cell surface protein tactile precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030244" }, "gene_names": [ { "name": "CD96", "type": "recommended", "evidence": [ { "id": "Q3MHP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP9" } ] }, { "name": "CD96", "type": "synonym", "evidence": [ { "id": "NP_001030244", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030244" } ] }, { "name": "TACTILE", "type": "synonym", "evidence": [ { "id": "NP_001030244", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030244" } ] } ], "protein_names": [ { "name": "T-cell surface protein tactile", "type": "recommended", "evidence": [ { "id": "Q3MHP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP9/entry#names_and_taxonomy" } ] }, { "name": "Cell surface antigen CD96", "type": "synonym", "evidence": [ { "id": "Q3MHP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP9/entry#names_and_taxonomy" } ] }, { "name": "T cell activation, increased late expression", "type": "synonym", "evidence": [ { "id": "NP_001030244", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030244" } ] }, { "name": "T cell-activated increased late expression protein", "type": "synonym", "evidence": [ { "id": "Q3MHP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP9/entry#names_and_taxonomy" } ] }, { "name": "T-cell surface protein tactile precursor", "type": "synonym", "evidence": [ { "id": "NP_001030244", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030244" } ] }, { "name": "T-cell surface protein tactile", "type": "synonym", "evidence": [ { "id": "NP_001030244", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030244" } ] }, { "name": "cell surface antigen CD96", "type": "synonym", "evidence": [ { "id": "NP_001030244", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030244" } ] }, { "name": "t cell-activated increased late expression protein", "type": "synonym", "evidence": [ { "id": "NP_001030244", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030244" } ] } ], "function": [ { "annotation": "May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3MHP9", "url": "https://www.uniprot.org/uniprotkb/Q3MHP9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHP9", "url": "https://www.uniprot.org/uniprotkb/Q3MHP9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CD96", "url": "https://www.uniprot.org/uniprotkb/Q3MHP9", "locus": { "chromosome": "1", "start_pos": 56402835, "end_pos": 56306243, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014441", "url": "https://www.ensembl.org/id/ENSBTAG00000014441" } ] } } ], "crossref": [ { "id": "Q3MHP9", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHP9", "database": "AlphaFoldDB", "categories": [] }, { "id": "509578", "url": "https://www.ncbi.nlm.nih.gov/gene/509578", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042381", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042381", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509578", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509578", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3MHP9", "url": "https://www.orthodb.org/?gene=Q3MHP9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15317", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15317", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15317:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15317:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001030244", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030244", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3MHP9", "url": "https://www.uniprot.org/uniprotkb/Q3MHP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHP9-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHP9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKKWTYCAVYSIIQMHLVRGIVEETFGAEEHIYALPGSDVNLTCQTQKKGILVQMQWSKVTDKVDLLAVYHPQHGFYCDSKSACRSLVAFREPPGNVFEWTLYLRNVSSSTTGKYECSFTLYPEGIQTKIYSLKIQTNVAQEEWKNNHTIEIEINGTLEIPCFQNTSLEISSVLTFAWLVEDNGTQKTLTAGGHPISNSALFKDRVRIGTDYRLYLSPVQIHDDGWKFSCHVVVRPGRVLRSSTTVKVFAKPEIPMIVENNSMDVIGERIFTCSLRNVFPTANLTWFIQRSFPQGEREEMYTTSEKRKNKDGFWELKSVLTSAYDNKPAHSNNLTIWCMALSPAPGHKVWNSSSEKITFFLGSLNPPIDSPLNATESTLGTRPSLANSISPTGYRTPSSTAHVDVSTSTSNVILPSVQTSNSDVPTRGFNYSWTSSGKDAKHSAPWMPSETNSSPSSGAGSTLPGDIFTSTTRASSEVPTTANVSTKNNHITGTVISKPKDGMSWPVIVAALLLSCFVLFGLGVRKWCQYQKEIMQRPPPFKPPPPPIKYTCIQESIGSDLPCHELETL", "length": 570, "header": "sp|Q3MHP9-1|TACT_BOVIN Isoform 1 of T-cell surface protein tactile OS=Bos taurus OX=9913 GN=CD96 PE=2 SV=1 CANONICAL=Q3MHP9-1" }, "isoforms": [ { "isoform_ac": "Q3MHP9-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHP9/entry#Q3MHP9-1", "sequence": { "sequence": "MEKKWTYCAVYSIIQMHLVRGIVEETFGAEEHIYALPGSDVNLTCQTQKKGILVQMQWSKVTDKVDLLAVYHPQHGFYCDSKSACRSLVAFREPPGNVFEWTLYLRNVSSSTTGKYECSFTLYPEGIQTKIYSLKIQTNVAQEEWKNNHTIEIEINGTLEIPCFQNTSLEISSVLTFAWLVEDNGTQKTLTAGGHPISNSALFKDRVRIGTDYRLYLSPVQIHDDGWKFSCHVVVRPGRVLRSSTTVKVFAKPEIPMIVENNSMDVIGERIFTCSLRNVFPTANLTWFIQRSFPQGEREEMYTTSEKRKNKDGFWELKSVLTSAYDNKPAHSNNLTIWCMALSPAPGHKVWNSSSEKITFFLGSLNPPIDSPLNATESTLGTRPSLANSISPTGYRTPSSTAHVDVSTSTSNVILPSVQTSNSDVPTRGFNYSWTSSGKDAKHSAPWMPSETNSSPSSGAGSTLPGDIFTSTTRASSEVPTTANVSTKNNHITGTVISKPKDGMSWPVIVAALLLSCFVLFGLGVRKWCQYQKEIMQRPPPFKPPPPPIKYTCIQESIGSDLPCHELETL", "length": 570, "header": "sp|Q3MHP9-1|TACT_BOVIN Isoform 1 of T-cell surface protein tactile OS=Bos taurus OX=9913 GN=CD96 PE=2 SV=1 CANONICAL=Q3MHP9-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) 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Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3MHQ4", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ4#function" }, { "database": "UniProtKB", "id": "O43623", "url": "https://www.uniprot.org/uniprotkb/O43623#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHQ4", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNAI2", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ4", "locus": { "chromosome": "14", "start_pos": 19941415, "end_pos": 19945240, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013227", "url": "https://www.ensembl.org/id/ENSBTAG00000013227" } ] } } ], "crossref": [ { "id": "Q3MHQ4", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHQ4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013227", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013227", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "520631", "url": "https://www.ncbi.nlm.nih.gov/gene/520631", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520631", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520631", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HFNSAKK", "url": "https://omabrowser.org/oma/group/HFNSAKK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3MHQ4", "url": "https://www.orthodb.org/?gene=Q3MHQ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24388", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24388", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24388:SF42", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24388:SF42", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029710", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3MHQ4", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHQ4-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRSFLVKKHFNASKKPNYSELDTHTVIISPCLYEGYPVPVIPQPEVLRSGAYSPIAVWTTASPFHAPLPAGLSPLSGYPASLGRVSPPPPSDTSSKDHSGSESPISDEEERLQSKLSDPHAIEAEKFQCNLCNKTYSTFSGLGKHKQLHCDAQSRKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCSHCSRAFADRSNLRAHLQTHSDVKKYQCKSCSKTFSRMSLLHKHEESGCCAAH", "length": 268, "header": "sp|Q3MHQ4-1|SNAI2_BOVIN Isoform 1 of Zinc finger protein SNAI2 OS=Bos taurus OX=9913 GN=SNAI2 PE=2 SV=1 CANONICAL=Q3MHQ4-1" }, "isoforms": [ { "isoform_ac": "Q3MHQ4-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ4/entry#Q3MHQ4-1", "sequence": { "sequence": "MPRSFLVKKHFNASKKPNYSELDTHTVIISPCLYEGYPVPVIPQPEVLRSGAYSPIAVWTTASPFHAPLPAGLSPLSGYPASLGRVSPPPPSDTSSKDHSGSESPISDEEERLQSKLSDPHAIEAEKFQCNLCNKTYSTFSGLGKHKQLHCDAQSRKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCSHCSRAFADRSNLRAHLQTHSDVKKYQCKSCSKTFSRMSLLHKHEESGCCAAH", "length": 268, "header": "sp|Q3MHQ4-1|SNAI2_BOVIN Isoform 1 of Zinc finger protein SNAI2 OS=Bos taurus OX=9913 GN=SNAI2 PE=2 SV=1 CANONICAL=Q3MHQ4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:520631", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520631", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1U981-1", "protein_name": "Zinc finger protein SNAI2", "gene_name": "SNAI2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPRSFLVKKHFNASKKPNYSELDTHTVIVSPYLYESYPMPVIPQPEILSSRAYSPIAVWTSAAPFHAPLPNGLSPLSGYPPPLGRVSPPPPSDTSSKDHSGSESPVSDEEERLQSKLSDPHAIEAEKFQCNLCSKTYSTFSGLGKHKQLHCDAQSRKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCSRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH", "length": 268 }, "evidence": [ { "id": "Q3MHQ4", "url": "https://omabrowser.org/oma/group/Q3MHQ4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XHQ3-1", "protein_name": "Zinc finger protein SNAI2", "gene_name": "SNAI2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPRSFLVKKHFNSSKKPNYSELDTHTVIISPYLYESYPVPIIPQPEILSSVAYNPITVWTTTGLLPSPLPNDLSPLSGYPSSLGRVSPPPPSDTSSKDHSGSESPISDEEERIQSKLSDPHAIEAEKFQCGLCNKTYSTFSGLAKHKQLHCDAQSRKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCNRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH", "length": 268 }, "evidence": [ { "id": "Q3MHQ4", "url": "https://omabrowser.org/oma/group/Q3MHQ4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HQT7-1", "protein_name": "Zinc finger protein SNAI2", "gene_name": "Snai2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPRSFLVKKHFNASKKPNYSELDTHTVIISPYLYESYPMPVIPKPEILSSGAYSPITVWTSAAPFHSPLPSGLSPLAGYSSPLGRVSPPPPSDTSSKDHSGSESPISDEEERLQAKLSDPHAIEAEKFQCNLCNKTYSTFSGLAKHKQLHCDAQSRKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCNRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH", "length": 268 }, "evidence": [ { "id": "Q3MHQ4", "url": "https://omabrowser.org/oma/group/Q3MHQ4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O08954-1", "protein_name": "Zinc finger protein SNAI2", "gene_name": "Snai2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPRSFLVKKHFNASKKPNYSELDTHTVIISPYLCESYPMPVIPKPEILTSGAYSPITVWTSAVPFHSPLPSGLSPLTGYSSSLGRVSPLPSSDTSSKDHSGSESPISDEEERLQPKLSDPHAIEAEKFQCNLCNKTYSTFSGLAKHKQLHCDAQARKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCNRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH", "length": 268 }, "evidence": [ { "id": "Q3MHQ4", "url": "https://omabrowser.org/oma/group/Q3MHQ4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O43623-1", "protein_name": "Zinc finger protein SNAI2", "gene_name": "SNAI2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPRSFLVKKHFNASKKPNYSELDTHTVIISPYLYESYSMPVIPQPEILSSGAYSPITVWTTAAPFHAQLPNGLSPLSGYSSSLGRVSPPPPSDTSSKDHSGSESPISDEEERLQSKLSDPHAIEAEKFQCNLCNKTYSTFSGLAKHKQLHCDAQSRKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCNRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH", "length": 268 }, "evidence": [ { "id": "Q3MHQ4", "url": "https://omabrowser.org/oma/group/Q3MHQ4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P97469-1", "protein_name": "Zinc finger protein SNAI2", "gene_name": "Snai2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRSFLVKKHFNASKKPNYSELDTHTVIISPYLYESYPIPVIPKPEILTSGAYSPITVWTSSAAPLHSPLPSGLSPLTGYSSSLGRVSPPPSSDTSSKDHSGSESPISDEEERLQPKLSDPHAIEAEKFQCNLCNKTYSTFSGLAKHKQLHCDAQSRKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCNRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH", "length": 269 }, "evidence": [ { "id": "Q3MHQ4", "url": "https://omabrowser.org/oma/group/Q3MHQ4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q3MHQ4", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ4" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3MHQ4", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ4" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "Q3MHQ4", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3MHQ4", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3MHQ4", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q3MHQ4", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ4" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q3MHQ4", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ4" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q3MHQ4", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 18, "end_pos": 20, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHQ4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 268, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHQ4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHQ4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 }, { "start_pos": 134, "end_pos": 136 }, { "start_pos": 18, "end_pos": 20 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHQ7-1", "uniprot_ac": "Q3MHQ7", "uniprot_id": "TM86A_BOVIN", "mass": { "chemical_mass": 26427.0, "monoisotopic_mass": 26427.0 }, "refseq": { "ac": "NP_001030465", "name": "lysoplasmalogenase TMEM86A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030465" }, "gene_names": [ { "name": "TMEM86A", "type": "recommended", "evidence": [ { "id": "Q3MHQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ7" } ] }, { "name": "TMEM86A", "type": "synonym", "evidence": [ { "id": "NP_001030465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030465" } ] } ], "protein_names": [ { "name": "Lysoplasmalogenase TMEM86A", "type": "recommended", "evidence": [ { "id": "Q3MHQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ7/entry#names_and_taxonomy" } ] }, { "name": "3.3.2.2", "type": "synonym", "evidence": [ { "id": "Q3MHQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ7/entry#names_and_taxonomy" } ] }, { "name": "Transmembrane protein 86A", "type": "synonym", "evidence": [ { "id": "Q3MHQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ7/entry#names_and_taxonomy" } ] }, { "name": "lysoplasmalogenase TMEM86A", "type": "synonym", "evidence": [ { "id": "NP_001030465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030465" } ] }, { "name": "lysoplasmalogenase-like protein TMEM86A", "type": "synonym", "evidence": [ { "id": "NP_001030465", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030465" } ] } ], "function": [ { "annotation": "Catalyzes the hydrolysis of the vinyl ether bond of choline or ethanolamine lysoplasmalogens, forming fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine, respectively and is specific for the sn-2-deacylated (lyso) form of plasmalogen (By similarity). Plays an important role in lysoplasmalogen metabolism in the adipocyte tissue and macrophages (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3MHQ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ7#function" }, { "database": "UniProtKB", "id": "Q8N2M4", "url": "https://www.uniprot.org/uniprotkb/Q8N2M4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHQ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM86A", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ7", "locus": { "chromosome": "29", "start_pos": 26067916, "end_pos": 26072270, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000048059", "url": "https://www.ensembl.org/id/ENSBTAG00000048059" } ] } } ], "crossref": [ { "id": "Q3MHQ7", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHQ7", "database": "AlphaFoldDB", "categories": [] }, { "id": "532018", "url": "https://www.ncbi.nlm.nih.gov/gene/532018", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012506", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012506", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532018", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532018", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3MHQ7", "url": "https://www.orthodb.org/?gene=Q3MHQ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31885", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31885", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31885:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31885:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07947", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07947", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030465", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16905", "url": "https://www.rhea-db.org/rhea/16905", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "22544", "url": "https://www.rhea-db.org/rhea/22544", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3MHQ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHQ7-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSPVTVVKSEGPKLVPFFKATCVYFVLWLPSSSPSWVSALIKCLPIFCLWLFLLAHGLGFLLTHPSATRIFVGLVFSAIGDAFLIWQDQGYFVHGMLMFAVTHMLYASAFGMRPLGLRTGLLMVILSGLCYAFLYPNLTGAFTYVVGVYVAIIGFMGWRAMAGLQLVGAAWRWTELAAGTGALLFIVSDLTIALDKFCFPVPYSRALIMSTYYAAQMLIALSAVESREPVEDYRLSKAK", "length": 240, "header": "sp|Q3MHQ7-1|TM86A_BOVIN Isoform 1 of Lysoplasmalogenase TMEM86A OS=Bos taurus OX=9913 GN=TMEM86A PE=2 SV=1 CANONICAL=Q3MHQ7-1" }, "isoforms": [ { "isoform_ac": "Q3MHQ7-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ7/entry#Q3MHQ7-1", "sequence": { "sequence": "MVSPVTVVKSEGPKLVPFFKATCVYFVLWLPSSSPSWVSALIKCLPIFCLWLFLLAHGLGFLLTHPSATRIFVGLVFSAIGDAFLIWQDQGYFVHGMLMFAVTHMLYASAFGMRPLGLRTGLLMVILSGLCYAFLYPNLTGAFTYVVGVYVAIIGFMGWRAMAGLQLVGAAWRWTELAAGTGALLFIVSDLTIALDKFCFPVPYSRALIMSTYYAAQMLIALSAVESREPVEDYRLSKAK", "length": 240, "header": "sp|Q3MHQ7-1|TM86A_BOVIN Isoform 1 of Lysoplasmalogenase TMEM86A OS=Bos taurus OX=9913 GN=TMEM86A PE=2 SV=1 CANONICAL=Q3MHQ7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:532018", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532018", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "alkenylglycerophosphocholine hydrolase activity", "id": "GO:0047408", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047408", "evidence": [ { "database": "UniProtKB", "id": "Q3MHQ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ7" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "Q3MHQ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "Q3MHQ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3MHQ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ7" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3MHQ7", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16905", "name": "", "equation": "a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHQ7-1", "Q3T0W0-1", "A0A3Q1MEA9-1" ], "evidence": [ { "id": "16905", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16905" } ] }, { "id": "22544", "name": "", "equation": "a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHQ7-1", "Q3T0W0-1", "A0A3Q1MEA9-1" ], "evidence": [ { "id": "22544", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22544" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MEA9", "gene_name": "TMEM86A", "activity": [ { "ec_number": "3.3.2.2", "activity": "a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine.", "evidence": [ { "id": "A0A3Q1MEA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEA9" } ] }, { "ec_number": "3.3.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1MEA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEA9" } ] } ] }, { "uniprot_ac": "Q3MHQ7", "gene_name": "TMEM86A", "activity": [ { "ec_number": "3.3.2.2", "activity": "a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine.", "evidence": [ { "id": "Q3MHQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ7" } ] }, { "ec_number": "3.3.2.2", "activity": "", "evidence": [ { "id": "Q3MHQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHQ7" } ] } ] }, { "uniprot_ac": "Q3T0W0", "gene_name": "TMEM86B", "activity": [ { "ec_number": "3.3.2.2", "activity": "a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine.", "evidence": [ { "id": "Q3T0W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0W0" } ] }, { "ec_number": "3.3.2.2", "activity": "", "evidence": [ { "id": "Q3T0W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0W0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHQ7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 240, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHQ7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHQ7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.3.2.2", "ec_name": "a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine.", "evidence": [ { "id": "3.3.2.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.2" } ] } ], 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHR5-1", "uniprot_ac": "Q3MHR5", "uniprot_id": "SRSF2_BOVIN", "mass": { "chemical_mass": 25476.0, "monoisotopic_mass": 25476.0 }, "refseq": { "ac": "NP_001421924", "name": "serine/arginine-rich splicing factor 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421924" }, "gene_names": [ { "name": "SRSF2", "type": "recommended", "evidence": [ { "id": "Q3MHR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHR5" } ] }, { "name": "SFRS2", "type": "synonym", "evidence": [ { "id": "NP_001421924", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421924" }, { "id": "Q3MHR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHR5" } ] }, { "name": "SRSF2", "type": "synonym", "evidence": [ { "id": "NP_001421924", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421924" } ] } ], "protein_names": [ { "name": "Serine/arginine-rich splicing factor 2", "type": "recommended", "evidence": [ { "id": "Q3MHR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHR5/entry#names_and_taxonomy" } ] }, { "name": "SC-35", "type": "synonym", "evidence": [ { "id": "NP_001421924", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421924" }, { "id": "Q3MHR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHR5/entry#names_and_taxonomy" } ] }, { "name": "Splicing component, 35 kDa", "type": "synonym", "evidence": [ { "id": "Q3MHR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHR5/entry#names_and_taxonomy" } ] }, { "name": "Splicing factor SC35", "type": "synonym", 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"id": "NP_001421924", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421924" } ] } ], "function": [ { "annotation": "Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.", "evidence": [ { "database": "UniProtKB", "id": "Q3MHR5", "url": "https://www.uniprot.org/uniprotkb/Q3MHR5#function" }, { "database": "UniProtKB", "id": "Q01130", "url": "https://www.uniprot.org/uniprotkb/Q01130#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHR5", "url": "https://www.uniprot.org/uniprotkb/Q3MHR5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SRSF2", "url": "https://www.uniprot.org/uniprotkb/Q3MHR5", "locus": { "chromosome": "19", "start_pos": 55047192, "end_pos": 55043351, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018258", "url": "https://www.ensembl.org/id/ENSBTAG00000018258" } ] } } ], "crossref": [ { "id": "Q3MHR5", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHR5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018258", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018258", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12311", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12311", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508312", "url": "https://www.ncbi.nlm.nih.gov/gene/508312", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003954", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003954", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508312", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508312", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PLIRCDV", "url": "https://omabrowser.org/oma/group/PLIRCDV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3MHR5", "url": "https://www.orthodb.org/?gene=Q3MHR5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48028", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48028", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48028:SF4", "url": 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"kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHY8-1", "uniprot_ac": "Q3MHY8", "uniprot_id": "RBM7_BOVIN", "mass": { "chemical_mass": 29963.0, "monoisotopic_mass": 29963.0 }, "refseq": { "ac": "NP_001029659", "name": "RNA-binding protein 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029659" }, "gene_names": [ { "name": "RBM7", "type": "recommended", "evidence": [ { "id": "Q3MHY8", "database": 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directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs). Participates in several biological processes including DNA damage response (DDR) and stress response. During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome. Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability.", "evidence": [ { "database": "UniProtKB", "id": "Q3MHY8", "url": "https://www.uniprot.org/uniprotkb/Q3MHY8#function" }, { "database": "UniProtKB", "id": "Q9Y580", "url": "https://www.uniprot.org/uniprotkb/Q9Y580#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHY8", "url": "https://www.uniprot.org/uniprotkb/Q3MHY8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RBM7", "url": "https://www.uniprot.org/uniprotkb/Q3MHY8", "locus": { "chromosome": "15", "start_pos": 24927867, "end_pos": 24920578, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008219", "url": "https://www.ensembl.org/id/ENSBTAG00000008219" } ] } } ], "crossref": [ { "id": "Q3MHY8", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHY8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008219", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008219", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12592", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12592", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515307", "url": "https://www.ncbi.nlm.nih.gov/gene/515307", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052285", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052285", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515307", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515307", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MRIQFRS", "url": "https://omabrowser.org/oma/group/MRIQFRS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3MHY8", "url": "https://www.orthodb.org/?gene=Q3MHY8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13798", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13798", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13798:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13798:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9930044", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9930044", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029659", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3MHY8", "url": "https://www.uniprot.org/uniprotkb/Q3MHY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3MHY8-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHY8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAAAAEADRTLFVGNLETKVTEELLFELFHQAGPVIKVKIPKDKDGKPKQFAFVNFKHEVSVPYAMNLLNGIKLFGRPIKIQFRAGSSHASQEVSLSYPQHHVGNSSPTSTSPSRTVDNMTPSAQTIQRSFSSSENFQRQAVMNNVLRQMSYGGKFGSPHLDQSGFSPSAQSHNHTFNQSSSSQWRQDTPSSQRKVRLNSHPYVMDRHYSREQRYSDLSDHHYRGNRDDFFYEDRNHDGWSHDYDNRRDSGRNGKWRSSRH", "length": 262, "header": "sp|Q3MHY8-1|RBM7_BOVIN Isoform 1 of RNA-binding protein 7 OS=Bos taurus OX=9913 GN=RBM7 PE=2 SV=1 CANONICAL=Q3MHY8-1" }, "isoforms": [ { "isoform_ac": "Q3MHY8-1", "url": "https://www.uniprot.org/uniprotkb/Q3MHY8/entry#Q3MHY8-1", "sequence": { "sequence": "MGAAAAEADRTLFVGNLETKVTEELLFELFHQAGPVIKVKIPKDKDGKPKQFAFVNFKHEVSVPYAMNLLNGIKLFGRPIKIQFRAGSSHASQEVSLSYPQHHVGNSSPTSTSPSRTVDNMTPSAQTIQRSFSSSENFQRQAVMNNVLRQMSYGGKFGSPHLDQSGFSPSAQSHNHTFNQSSSSQWRQDTPSSQRKVRLNSHPYVMDRHYSREQRYSDLSDHHYRGNRDDFFYEDRNHDGWSHDYDNRRDSGRNGKWRSSRH", "length": 262, "header": "sp|Q3MHY8-1|RBM7_BOVIN Isoform 1 of RNA-binding protein 7 OS=Bos taurus OX=9913 GN=RBM7 PE=2 SV=1 CANONICAL=Q3MHY8-1" }, "locus": { "chromosome": "15", "start_pos": 24926789, "end_pos": 24920585, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010804.5", "url": "https://www.ensembl.org/id/ENSBTAT00000010804.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010804.3", "url": "https://www.ensembl.org/id/ENSBTAP00000010804.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 133, "end_pos": 133, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHY8", "url": "https://www.uniprot.org/uniprotkb/Q3MHY8" } ], "site_lbl": "Ser133" }, { "start_pos": 134, "end_pos": 134, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHY8", "url": "https://www.uniprot.org/uniprotkb/Q3MHY8" } ], "site_lbl": "Ser134" }, { "start_pos": 201, "end_pos": 201, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3MHY8", "url": "https://www.uniprot.org/uniprotkb/Q3MHY8" } ], "site_lbl": "Ser201" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515307", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515307", "resource": "KEGG Pathway" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" }, { "id": "R-BTA-9930044", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9930044", "resource": "Reactome", "description": "Nuclear RNA decay" } ], "orthologs": [ { "uniprot_canonical_ac": "F1NGK7-1", "protein_name": "RNA-binding protein 7", "gene_name": "RBM7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGGTAAEADRTLFVGNLDPKVTEELIFELFHQAGPVIKVKIPKDKDGKQKQFAFVSFKHEESVPYGMNLLNGIKLYGRPINIQFRSGSSHASQDSNSSCLPHGAASLGPSGTPHLASRHDRNTDSMVAAGFPSMHRSLPSHDNLQRQAGMHGAVWQQSQPGFAVPGYQHGHSLGHPSASHMLRRPDVAALRKSRMGSHPYYPDSRHLGREQRAGDRGSDYGRGKRDDYGFEDRGHISEHHYRGSRDEPFYDDRNRSAWSHDYDSRRESYREGSWRLTRH", "length": 279 }, "evidence": [ { "id": "Q3MHY8", "url": "https://omabrowser.org/oma/group/Q3MHY8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SJV7-1", "protein_name": "RNA-binding protein 7", "gene_name": "RBM7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGAAAAEADRTLFVGNLETKVTEELLFELFHQAGPVIKVKIPKDKDGKPKQFAFVNFKHEVSVPYAMNLLNGIKLFGRPIKIQFRSGSSHASQEVSLSYPQHHVGNSSPTSTSPSRYERTVDNMTPSTQILQRSFSCSENFQRQAVMNNVLRQMSYGGKFGSPHLDPSGFSPSVQSHNHSFNQSSSSPWRQDTPSQRKVRQNSHPYLADRHYSREQRYADHGSDHHYRGNRDDFFYEDRNHDGWSHDYDNRRDSGRDGKWRSSRH", "length": 265 }, "evidence": [ { "id": "Q3MHY8", "url": "https://omabrowser.org/oma/group/Q3MHY8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9CQT2-1", "protein_name": "RNA-binding protein 7", "gene_name": "Rbm7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGAAAAEADRTLFVGNLETKVTEELLFELFHQAGPVIKVKIPKDKDGKLKQFAFVNFKHEVSVPYAMNLLNGIKLFGRPIKIQFRSGSSHASQDASVSYPQHHVGNLSPTSTSPNSYERTVGNVSPTAQMVQRSFSSPEDYQRQAVMNSVFRQMSYAGKFGSPHADQLGFSPSAQPHGHTFNQSSSSQWRQDALSSQRKRQNSHPYLADRHYSREQRYSDHGSDYHYRGSREDFYYDDRNHDGWSHDYDNRRDSSRGGKWPSSRH", "length": 265 }, "evidence": [ { "id": "Q3MHY8", "url": "https://omabrowser.org/oma/group/Q3MHY8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y580-1", "protein_name": "RNA-binding protein 7", "gene_name": "RBM7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGAAAAEADRTLFVGNLETKVTEELLFELFHQAGPVIKVKIPKDKDGKPKQFAFVNFKHEVSVPYAMNLLNGIKLYGRPIKIQFRSGSSHAPQDVSLSYPQHHVGNSSPTSTSPSRYERTMDNMTSSAQIIQRSFSSPENFQRQAVMNSALRQMSYGGKFGSSPLDQSGFSPSVQSHSHSFNQSSSSQWRQGTPSSQRKVRMNSYPYLADRHYSREQRYTDHGSDHHYRGKRDDFFYEDRNHDDWSHDYDNRRDSSRDGKWRSSRH", "length": 266 }, "evidence": [ { "id": "Q3MHY8", "url": "https://omabrowser.org/oma/group/Q3MHY8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q3MHY8", "url": "https://www.uniprot.org/uniprotkb/Q3MHY8" } ], "pmid": "" }, { "name": "single-stranded RNA binding", "id": "GO:0003727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003727", "evidence": [ { "database": "UniProtKB", "id": "Q3MHY8", "url": "https://www.uniprot.org/uniprotkb/Q3MHY8" } ], "pmid": "" }, { "name": "14-3-3 protein binding", "id": "GO:0071889", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071889", "evidence": [ { "database": "UniProtKB", "id": "Q3MHY8", "url": "https://www.uniprot.org/uniprotkb/Q3MHY8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3MHY8", "url": "https://www.uniprot.org/uniprotkb/Q3MHY8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3MHY8", "url": "https://www.uniprot.org/uniprotkb/Q3MHY8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "meiotic cell cycle", "id": "GO:0051321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051321", "evidence": [ { "database": "UniProtKB", "id": "Q3MHY8", "url": "https://www.uniprot.org/uniprotkb/Q3MHY8" } ], "pmid": "" }, { "name": "regulation of alternative mRNA splicing, via spliceosome", "id": "GO:0000381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000381", "evidence": [ { "database": "UniProtKB", "id": "Q3MHY8", "url": "https://www.uniprot.org/uniprotkb/Q3MHY8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" }, { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3MHY8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 262, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3MHY8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3MHY8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3MHY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHY8" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000255", "start_pos": 10, "end_pos": 87, "start_aa": "Arg", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 133, 134, 201 ], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 120, "end_pos": 122 }, { "start_pos": 175, "end_pos": 177 }, { "start_pos": 179, "end_pos": 181 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3MHZ5-1", "uniprot_ac": "Q3MHZ5", "uniprot_id": "FXYD6_BOVIN", "mass": { "chemical_mass": 10465.0, "monoisotopic_mass": 10465.0 }, "refseq": { "ac": "NP_001029571", "name": "FXYD domain-containing ion transport regulator 6 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029571" }, "gene_names": [ { "name": "FXYD6", "type": "recommended", "evidence": [ { "id": "Q3MHZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ5" } ] }, { "name": "FXYD6", "type": "synonym", "evidence": [ { "id": "NP_001029571", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029571" } ] } ], "protein_names": [ { "name": "FXYD domain-containing ion transport regulator 6", "type": "recommended", "evidence": [ { "id": "Q3MHZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ5/entry#names_and_taxonomy" } ] }, { "name": "FXYD domain-containing ion transport regulator 6 precursor", "type": "synonym", "evidence": [ { "id": "NP_001029571", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029571" } ] }, { "name": "Phosphohippolin", "type": "synonym", "evidence": [ { "id": "Q3MHZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ5/entry#names_and_taxonomy" } ] }, { "name": "phosphohippolin", "type": "synonym", "evidence": [ { "id": "NP_001029571", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029571" } ] } ], "function": [ { "annotation": "Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Reduces the apparent affinity for intracellular Na(+) with no change in the apparent affinity for extracellular K(+) (By similarity). 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"evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014354", "url": "https://www.ensembl.org/id/ENSBTAG00000014354" } ] } } ], "crossref": [ { "id": "Q3MHZ5", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHZ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014354", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014354", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511064", "url": "https://www.ncbi.nlm.nih.gov/gene/511064", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000272", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000272", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047297", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047297", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511064", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511064", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] 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"evidence": [ { "id": "NP_001034266", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034266" } ] }, { "name": "lectin, galactoside-binding, soluble, 9 (galectin 9)", "type": "synonym", "evidence": [ { "id": "NP_001034266", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034266" } ] } ], "function": [ { "annotation": "Binds galactosides. Has high affinity for the Forssman pentasaccharide. Ligand for HAVCR2/TIM3. Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death. Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth. Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function. Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation. Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection. Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells. Inhibits degranulation and induces apoptosis of mast cells. Induces maturation and migration of dendritic cells. Inhibits natural killer (NK) cell function. Can transform NK cell phenotype from peripheral to decidual during pregnancy. Astrocyte derived galectin-9 enhances microglial TNF production. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion. Highly selective to the anion urate.", "evidence": [ { "database": "UniProtKB", "id": "Q3MHZ8", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ8#function" }, { "database": "UniProtKB", "id": "O00182", "url": "https://www.uniprot.org/uniprotkb/O00182#function" }, { "database": "UniProtKB", "id": "O08573", "url": "https://www.uniprot.org/uniprotkb/O08573#function" }, { "database": "UniProtKB", "id": "P97840", "url": "https://www.uniprot.org/uniprotkb/P97840#function" } ] }, { "annotation": "The Tim-3/Gal-9 pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001034266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034266" }, { "database": "PubMed", "id": "22621175", "url": "https://glygen.org/publication/PubMed/22621175" } ] }, { "annotation": "The relative abundance of PIBF, LGALS1, LGALS3, LGALS3BP, and LGALS9 mRNA would display a differential expression pattern in the endometrium.", "evidence": [ { "database": "RefSeq", "id": "NP_001034266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034266" }, { "database": "PubMed", "id": "21610087", "url": "https://glygen.org/publication/PubMed/21610087" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3MHZ8", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LGALS9", "url": "https://www.uniprot.org/uniprotkb/Q3MHZ8", "locus": { "chromosome": "19", "start_pos": 19387179, "end_pos": 19368438, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006846", "url": "https://www.ensembl.org/id/ENSBTAG00000006846" } ] } } ], "crossref": [ { "id": "Q3MHZ8", "url": "https://alphafold.ebi.ac.uk/entry/Q3MHZ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00070", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00070", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510813", "url": "https://www.ncbi.nlm.nih.gov/gene/510813", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510813", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510813", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3MHZ8", "url": "https://www.orthodb.org/?gene=Q3MHZ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11346", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11346", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11346:SF80", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11346:SF80", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00337", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00337", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": 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"https://www.uniprot.org/uniprotkb/Q3MHZ8/entry#Q3MHZ8-1", "sequence": { "sequence": "MAFGGAQASYINPVVPFTGMIQGGLQDGHKITIIGAVLPSGGNRFAVNLQTGYNDSDIAFHFNPRFEEGGYVVCNTKQRGSWGTEERKMHMPFQRGCSFELCFQVQSSDFRVMVNGNLFTQYAHRVPFHRIDAISITGVVQLSSISFQNIRAAPKQPACSKVQFSQAVCLPPRPRGRKSNPPGIWPANSAPIAQTFVHTIHSAPGQMFPNPVIPPAVYPNPVYQLPFFTSILGGLYPSKSILVSGTILPSAQRFYINLRSGSDIAFHLNPRFNENAVVRNTQINGSWGSEERSLPRGMPFFRGQSFSVWIMCEGHCFKVAVDSQHLFEYHHRLKNLPAINNLEVGGDIQLTHVQT", "length": 355, "header": "sp|Q3MHZ8-1|LEG9_BOVIN Isoform 1 of Galectin-9 OS=Bos taurus OX=9913 GN=LGALS9 PE=2 SV=1 CANONICAL=Q3MHZ8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Endometrial expression of progesterone-induced blocking factor and galectins-1, -3, -9, and -3 binding protein in the luteal phase and early pregnancy in cattle.", "journal": "Physiological genomics", "date": "2011-07-27", "authors": "Okumu L A, Fair T, Szekeres-Bartho J, O'Doherty A M, Crowe M A, Roche J F, Lonergan P, Forde N", "evidence": [ { "database": "RefSeq", "id": "NP_001034266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034266" } ], "reference": [ { "type": "PubMed", "id": "21610087", "url": "https://glygen.org/publication/PubMed/21610087" } ] }, { "title": "Increased bovine Tim-3 and its ligand expressions during bovine leukemia virus infection.", "journal": "Veterinary research", "date": "2012-05-23", "authors": "Okagawa Tomohiro, Konnai Satoru, Ikebuchi Ryoyo, Suzuki Saori, Shirai Tatsuya, Sunden Yuji, Onuma Misao, Murata Shiro, Ohashi Kazuhiko", "evidence": [ { "database": "RefSeq", "id": "NP_001034266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034266" } ], "reference": [ { "type": "PubMed", "id": "22621175", "url": "https://glygen.org/publication/PubMed/22621175" } ] } ], "pathway": [ { "id": "bta:510813", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510813", "resource": "KEGG Pathway" } ], "orthologs": [], 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{ "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3SWX7-1", "uniprot_ac": "Q3SWX7", "uniprot_id": "ANXA3_BOVIN", "mass": { "chemical_mass": 36140.0, "monoisotopic_mass": 36140.0 }, "refseq": { "ac": "NP_001030402", "name": "annexin A3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030402" }, "gene_names": [ { "name": "ANXA3", "type": "recommended", "evidence": [ { "id": "Q3SWX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWX7" } ] }, { "name": "ANXA3", "type": "synonym", "evidence": [ { "id": "NP_001030402", "database": "RefSeq", 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"type": "synonym", "evidence": [ { "id": "NP_001030402", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030402" } ] }, { "name": "lipocortin III", "type": "synonym", "evidence": [ { "id": "NP_001030402", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030402" } ] } ], "function": [ { "annotation": "Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SWX7", "url": "https://www.uniprot.org/uniprotkb/Q3SWX7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SWX7", "url": "https://www.uniprot.org/uniprotkb/Q3SWX7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANXA3", "url": "https://www.uniprot.org/uniprotkb/Q3SWX7", "locus": { "chromosome": "6", "start_pos": 93373380, "end_pos": 93301563, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010153", "url": "https://www.ensembl.org/id/ENSBTAG00000010153" } ] } } ], "crossref": [ { "id": "Q3SWX7", "url": "https://alphafold.ebi.ac.uk/entry/Q3SWX7", "database": "AlphaFoldDB", "categories": [] }, { "id": "518050", "url": "https://www.ncbi.nlm.nih.gov/gene/518050", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037104", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037104", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518050", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518050", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SWX7", "url": "https://www.orthodb.org/?gene=Q3SWX7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10502", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10502", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10502:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10502:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00191", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00191", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030402", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SWX7", "url": "https://www.uniprot.org/uniprotkb/Q3SWX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SWX7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SWX7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASIWVGKRGTIRDYAGFNPSVDAEAIRKAIRGIGTDEKTLISILTERTNAQRLLIAKEYQALCGKELKDDLKGDLSGHFKHLMVALVTPPAVFDAKQLKKSMKGMGTNEDALIEILTTRTSKQMQEIGHAYYTAYKKSLGDEISSETSGDFRKALLILANGRRDESLKVDEQLARKDAQILYNAGEKRWGTDEDAFTNILCLRSFPQLKLTFDEYRNISQKDIEDSIKGELSGHFEDLLLAIVRCARNTPAFLAERLYRALKGAGTDEFTLNRIMVSRSEIDLLDIRAEFKKLSGYSLYSAIKSDTSGDYEITLLKICGGDD", "length": 323, "header": "sp|Q3SWX7-1|ANXA3_BOVIN Isoform 1 of Annexin A3 OS=Bos taurus OX=9913 GN=ANXA3 PE=2 SV=3 CANONICAL=Q3SWX7-1" }, "isoforms": [ { "isoform_ac": "Q3SWX7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SWX7/entry#Q3SWX7-1", "sequence": { "sequence": 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"database": "UniProtKB", "id": "Q3SWX7", "url": "https://www.uniprot.org/uniprotkb/Q3SWX7" } ], "pmid": "" }, { "name": "phosphatidylserine binding", "id": "GO:0001786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001786", "evidence": [ { "database": "UniProtKB", "id": "Q3SWX7", "url": "https://www.uniprot.org/uniprotkb/Q3SWX7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 218, "end_pos": 220, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SWX7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 323, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SWX7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SWX7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 267 ], "sequon_annotation_sites": [ { "start_pos": 218, "end_pos": 220 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { 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"field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SWY5-1", "uniprot_ac": "Q3SWY5", "uniprot_id": "NOSIP_BOVIN", "mass": { "chemical_mass": 33043.0, "monoisotopic_mass": 33043.0 }, "refseq": { "ac": "NP_001068970", "name": "nitric oxide synthase-interacting protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068970" }, "gene_names": [ { "name": "NOSIP", "type": "recommended", "evidence": [ { "id": "Q3SWY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5" } ] }, { "name": "NOSIP", "type": "synonym", "evidence": [ { "id": "NP_001068970", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068970" } ] } ], "protein_names": [ { "name": "Nitric oxide synthase-interacting protein", "type": "recommended", "evidence": [ { "id": "Q3SWY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.27", "type": "synonym", "evidence": [ { "id": "Q3SWY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5/entry#names_and_taxonomy" } ] }, { "name": "E3 ubiquitin-protein ligase NOSIP", "type": "synonym", "evidence": [ { "id": "NP_001068970", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068970" }, { "id": "Q3SWY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5/entry#names_and_taxonomy" } ] }, { "name": "RING-type E3 ubiquitin transferase NOSIP", "type": "synonym", "evidence": [ { "id": "NP_001068970", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068970" }, { "id": "Q3SWY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5/entry#names_and_taxonomy" } ] }, { "name": "nitric oxide synthase-interacting protein", "type": "synonym", "evidence": [ { "id": "NP_001068970", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068970" } ] } ], "function": [ { "annotation": "Cdc37 has a direct regulatory interaction with endothelial nitric oxide synthase (eNOS) and may play an important role in mediating the eNOS protein complex formation.", "evidence": [ { "database": "RefSeq", "id": "NP_001068970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068970" }, { "database": "PubMed", "id": "16410463", "url": "https://glygen.org/publication/PubMed/16410463" } ] }, { "annotation": "E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SWY5", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5#function" }, { "database": "UniProtKB", "id": "Q9D6T0", "url": "https://www.uniprot.org/uniprotkb/Q9D6T0#function" }, { "database": "UniProtKB", "id": "Q9Y314", "url": "https://www.uniprot.org/uniprotkb/Q9Y314#function" } ] }, { "annotation": "Hydrogen peroxide down regulates endothelial dihydrofolate reductase expression in response to angiotensin Ii and underlies endothelial nitric oxide synthase dysfunction.", "evidence": [ { "database": "RefSeq", "id": "NP_001068970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068970" }, { "database": "PubMed", "id": "15941833", "url": "https://glygen.org/publication/PubMed/15941833" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SWY5", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NOSIP", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5", "locus": { "chromosome": "18", "start_pos": 55990005, "end_pos": 56002003, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014450", "url": "https://www.ensembl.org/id/ENSBTAG00000014450" } ] } } ], "crossref": [ { "id": "Q3SWY5", "url": "https://alphafold.ebi.ac.uk/entry/Q3SWY5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014450", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014450", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16661", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16661", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16662", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16662", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511234", "url": "https://www.ncbi.nlm.nih.gov/gene/511234", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016818", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016818", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511234", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511234", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PCVTKFM", "url": "https://omabrowser.org/oma/group/PCVTKFM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SWY5", "url": "https://www.orthodb.org/?gene=Q3SWY5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13063", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13063", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13063:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13063:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15906", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15906", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-203754", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-203754", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001068970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068970", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SWY5", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SWY5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKKEIARQMKAYEKQRGARREEQKELQRAAAQDHVRGFLEKEAAIVSRPLNPFTPKAASAGNGPDDAQPGSSAGPAGKDKDKALPSFWIPSLTPEAKATKLEKPSRIVTCPMSGKPLRMSDLTPVRFTPLDSSVDRVGLITRSERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVTGEKLTDRDIIVLQRGGTGFAGSGVKLQAEKSRPVMQA", "length": 302, "header": "sp|Q3SWY5-1|NOSIP_BOVIN Isoform 1 of Nitric oxide synthase-interacting protein OS=Bos taurus OX=9913 GN=NOSIP PE=2 SV=1 CANONICAL=Q3SWY5-1" }, "isoforms": [ { "isoform_ac": "Q3SWY5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5/entry#Q3SWY5-1", "sequence": { "sequence": "MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKKEIARQMKAYEKQRGARREEQKELQRAAAQDHVRGFLEKEAAIVSRPLNPFTPKAASAGNGPDDAQPGSSAGPAGKDKDKALPSFWIPSLTPEAKATKLEKPSRIVTCPMSGKPLRMSDLTPVRFTPLDSSVDRVGLITRSERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVTGEKLTDRDIIVLQRGGTGFAGSGVKLQAEKSRPVMQA", "length": 302, "header": "sp|Q3SWY5-1|NOSIP_BOVIN Isoform 1 of Nitric oxide synthase-interacting protein OS=Bos taurus OX=9913 GN=NOSIP PE=2 SV=1 CANONICAL=Q3SWY5-1" }, "locus": { "chromosome": "18", "start_pos": 55994006, "end_pos": 55990743, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019215.4", "url": "https://www.ensembl.org/id/ENSBTAT00000019215.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019215.3", "url": "https://www.ensembl.org/id/ENSBTAP00000019215.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 36, "end_pos": 36, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SWY5", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5" } ], "site_lbl": "Ser36" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2005-06-21", "authors": "Chalupsky Karel, Cai Hua", "evidence": [ { "database": "RefSeq", "id": "NP_001068970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068970" } ], "reference": [ { "type": "PubMed", "id": "15941833", "url": "https://glygen.org/publication/PubMed/15941833" } ] }, { "title": "Direct interaction of the cell division cycle 37 homolog inhibits endothelial nitric oxide synthase activity.", "journal": "Circulation research", "date": "2006-02-17", "authors": "Harris M Brennan, Bartoli Manuela, Sood Sarika G, Matts Robert L, Venema Richard C", "evidence": [ { "database": "RefSeq", "id": "NP_001068970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068970" } ], "reference": [ { "type": "PubMed", "id": "16410463", "url": "https://glygen.org/publication/PubMed/16410463" } ] } ], "pathway": [ { "id": "bta:511234", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511234", "resource": "KEGG Pathway" }, { "id": "R-BTA-203754", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-203754", "resource": "Reactome", "description": "NOSIP mediated eNOS trafficking" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QVZ0-1", "protein_name": "Nitric oxide synthase-interacting protein", "gene_name": "NOSIP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKKEIARQMKAYEKQRGARREEQKELQRAAAQDQVRGFLEKEAAIVSRPLNPFTPKAASGDSPDDAQPGPSAGPAGKDKDKALPSFWIPSLTPEAKATKLEKPSRVVTCPMSGKPLRMSDLTPVRFTPLDSSVDRVGLITRSERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVNGEKLTDRDIIVLQRGGTGFAGSGVKLQAEKSRPVMQA", "length": 301 }, "evidence": [ { "id": "Q3SWY5", "url": "https://omabrowser.org/oma/group/Q3SWY5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZH12-1", "protein_name": "Nitric oxide synthase-interacting protein", "gene_name": "Nosip", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKREIARQMKAYEKQRGARREEQKELQRAAAQDQVRGFLEKESAIVSRPLNPFMPKAATLPNTDGEQPGPSVGPLGKDKDKALPSFWIPSLTPEAKATKLEKPSRTVTCPMSGKPLRMSDLTSVRFTQLDDSVDRVGLITRSERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVNGDTLTERDIIVLQRGGTGFAGSGVKLQAEMSRPVMQA", "length": 301 }, "evidence": [ { "id": "Q3SWY5", "url": "https://omabrowser.org/oma/group/Q3SWY5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3ILN4-1", "protein_name": "Nitric oxide synthase-interacting protein", "gene_name": "Nosip", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKKEIARQMKAYEKQRGARREEQKQLQRAAAQDQVRGFLEKEAAIVSRPLNPFMPKAAPLPNTDGEQPGPSSGPPGKDKDKALPSFWIPSLTPEAKATKLEKPSRTVTCPMSGKPLRMSDLTPVRFTQLDDSVDRVGLITRSERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVNGDTLTERDIIVLQRGGTGFAGSGVKLQAEMSRPVMQA", "length": 301 }, "evidence": [ { "id": "Q3SWY5", "url": "https://omabrowser.org/oma/group/Q3SWY5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q55DU4-1", "protein_name": "Nitric oxide synthase-interacting protein homolog", "gene_name": "nosip", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MPRHSKHSCSNSGKFSNYERQLLKYGTTTERLGKDSIKNFDSCSLCLNDVIMPVICNKGHLYCKECILTSLIDQKKLIKIKEKEWEQYQNKLKYEQDQKQEKQHQDSIKEFEKNVITLEGIGSNDDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTTTTTTTTTTTSDVNNKDKEKKEIVEKEIKLNSYWVITPDNKDKAIEKPRSYTVCPADGKHPLKSAQLINVHFTNVKPSSSDSNDSNNQYCCPICSKVLSNSTKTRLLKRCGHVFCSCLDKFKEDSSSQLSCYVCDKPYTEDEIIQIHSGGTGFSGSGSNLEAKKYTHTAIV", "length": 333 }, "evidence": [ { "id": "Q3SWY5", "url": "https://omabrowser.org/oma/group/Q3SWY5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5U3S7-1", "protein_name": "Nitric oxide synthase-interacting protein", "gene_name": "nosip", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTRHGKNCTAGAVYTYHEKRKDTAASGYGTQSVRLGKDAIKDFDCCSLSLQPCRDPVLTEDGYLYEKEAILQYILHQKTEIAKKMKAYEKQKQALKSEGQLESKSEERERAEKFKQRENNIVSKPINPFTSGKSKDEGNQNGSTSSSSTDTSSGESSSSSALPSFWIPSLTPEAKPTLLKKPSKTVSCPMSGRPLKMSDLITVRFTPLDPSLDRVALLTRQDRYVCAVTKDTLGNSVPCAVLRPSGVVVTMECVEKLIKKDMVDPITGDKLKEKDIIPIQRGGTGFAGSGVDLKAKEARPVMQA", "length": 304 }, "evidence": [ { "id": "Q3SWY5", "url": "https://omabrowser.org/oma/group/Q3SWY5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9D6T0-1", "protein_name": "Nitric oxide synthase-interacting protein", "gene_name": "Nosip", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKREIARQVKAYEKQRGARREEQKELQRAAAQDQVRGFLEKEAAIVSRPLNPFMPKAATLPNTEGEQPGPSVGPVGKDKDKALPSFWIPSLTPEAKATKLEKPSRTVTCPMSGKPLRMSDLTSVRFTQLDDSVDRVGLITRSERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVNGDTLTERDIIVLQRGGTGFAGSGVKLQAEMSRPVMQA", "length": 301 }, "evidence": [ { "id": "Q3SWY5", "url": "https://omabrowser.org/oma/group/Q3SWY5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9SY88-1", "protein_name": "E3 ubiquitin-protein ligase CSU1", "gene_name": "CSU1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MPQRHSKNNNDLAYFTYDEKKKLGYGTQRERLGRDSIKPFDACSLCLKPFIDPMCCHKGHVFCRECILECFLAQKKDIQRRLAAHSSQKKQDKDEEEERLMLQKARELDEFDQQNHSAMPRNSDKNHNEDKNGFHGANSVKTTSFEEEALRTMKAFWLPSATPAASVRVDAPETHTVCPEGKEKLKLKNLFAIRFTEDNSEEEETKTKSASSSSYDKSYICPSCKVTLTNTMSLVALSSCGHVFCKKCAEKFMPVDKVCLVCDKPCKDRNLVGLKKGGTGFAEHDDHLEAKEYKHLGSGSGLGLVRPVKT", "length": 310 }, "evidence": [ { "id": "Q3SWY5", "url": "https://omabrowser.org/oma/group/Q3SWY5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VWV8-1", "protein_name": "Nitric oxide synthase-interacting protein homolog", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTRHARNCTAGAVYTYNEKKRDAAESGYGTNAQRLGKDSVKSFDCCSLTLQPCRRPVITKDGYLFDKEAILQYIVTKKNEYSRRLKEYERLRRAEEDKLSQEANSKQQARMERFVNAEKPAMTPAHSSAAASEKPSTSSAAAAASSESSSASSISNMTNGHEKKLPSFWLPSECPNAGLAKAQKPDATIYCPVSQKPLRVKDLIDVKFTLLKDGDTKRSLIAKEARYMCPITHDVLSNAVPCAVLRPTGDVVTMECVERLIRKDMIHPLTDRKLKEKDIIPLQRGGTGYATTNDHLQAKEKRPMLQA", "length": 307 }, "evidence": [ { "id": "Q3SWY5", "url": "https://omabrowser.org/oma/group/Q3SWY5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y314-1", "protein_name": "Nitric oxide synthase-interacting protein", "gene_name": "NOSIP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKKEIARQMKAYEKQRGTRREEQKELQRAASQDHVRGFLEKESAIVSRPLNPFTAKALSGTSPDDVQPGPSVGPPSKDKDKVLPSFWIPSLTPEAKATKLEKPSRTVTCPMSGKPLRMSDLTPVHFTPLDSSVDRVGLITRSERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVTGDKLTDRDIIVLQRGGTGFAGSGVKLQAEKSRPVMQA", "length": 301 }, "evidence": [ { "id": "Q3SWY5", "url": "https://omabrowser.org/oma/group/Q3SWY5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3SWY5", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3SWY5", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SWY5", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "Q3SWY5", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5" } ], "pmid": "" }, { "name": "molecular sequestering activity", "id": "GO:0140313", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140313", "evidence": [ { "database": "UniProtKB", "id": "Q3SWY5", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of nitric oxide biosynthetic process", "id": "GO:0045428", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045428", "evidence": [ { "database": "UniProtKB", "id": "Q3SWY5", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-203553", "name": "eNOS binds NOSIP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MY54-1", "Q3SWY5-1" ], "evidence": [ { "id": "R-BTA-203553", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-203553" } ] }, { "id": "R-BTA-203680", "name": "eNOS:NOSIP translocation from caveolae to intracellular compartments", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MY54-1", "Q3SWY5-1" ], "evidence": [ { "id": "R-BTA-203680", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-203680" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MY54", "gene_name": "NOS3", "activity": [ { "ec_number": "1.14.13.39", "activity": "2 L-arginine + 3 NADPH + 4 O2 + H(+) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H2O.", "evidence": [ { "id": "F1MY54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY54" } ] }, { "ec_number": "1.14.13.39", "activity": "", "evidence": [ { "id": "F1MY54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY54" } ] } ] }, { "uniprot_ac": "Q3SWY5", "gene_name": "NOSIP", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3SWY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SWY5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 302, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SWY5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SWY5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SWY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY5" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Nuclear localization signal", "eco_id": "ECO_0000250", "start_pos": 78, "end_pos": 101, "start_aa": "Lys", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 36 ], "sequon_annotation_sites": [ { "start_pos": 233, "end_pos": 235 }, { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3SWY8-1", "uniprot_ac": "Q3SWY8", "uniprot_id": "ZUP1_BOVIN", "mass": { "chemical_mass": 66307.0, "monoisotopic_mass": 66307.0 }, "refseq": { "ac": "NP_001029766", "name": "zinc finger-containing ubiquitin peptidase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029766" }, "gene_names": [ { "name": "ZUP1", "type": "recommended", "evidence": [ { "id": "Q3SWY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY8" } ] }, { "name": "C6orf113", "type": "synonym", "evidence": [ { "id": "NP_001029766", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029766" } ] }, { "name": "C9H6orf113", "type": "synonym", "evidence": [ { "id": "NP_001029766", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029766" } ] }, { "name": "DUB", "type": "synonym", "evidence": [ { "id": "NP_001029766", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029766" } ] }, { "name": "ZUFSP", "type": "synonym", "evidence": [ { "id": "NP_001029766", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029766" }, { "id": "Q3SWY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY8" } ] }, { "name": "ZUP1", "type": "synonym", "evidence": [ { "id": "NP_001029766", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029766" } ] } ], "protein_names": [ { "name": "Zinc finger-containing ubiquitin peptidase 1", "type": "recommended", "evidence": [ { "id": "Q3SWY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY8/entry#names_and_taxonomy" } ] }, { "name": "3.4.19.12", "type": "synonym", "evidence": [ { "id": "Q3SWY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY8/entry#names_and_taxonomy" } ] }, { "name": "DUB", "type": "synonym", "evidence": [ { "id": "Q3SWY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY8/entry#names_and_taxonomy" } ] }, { "name": "Lys-63-specific deubiquitinase ZUFSP", "type": "synonym", "evidence": [ { "id": "Q3SWY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY8/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger with UFM1-specific peptidase domain protein", "type": "synonym", "evidence": [ { "id": "Q3SWY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY8/entry#names_and_taxonomy" } ] }, { "name": "lys-63-specific deubiquitinase ZUFSP", "type": "synonym", "evidence": [ { "id": "NP_001029766", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029766" } ] }, { "name": "ubiquitin carboxyl-terminal hydrolase ZUFSP", "type": "synonym", "evidence": [ { "id": "NP_001029766", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029766" } ] }, { "name": "zinc finger with UFM1 specific peptidase domain", "type": "synonym", "evidence": [ { "id": "NP_001029766", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029766" } ] }, { "name": "zinc finger with UFM1-specific peptidase domain protein", "type": "synonym", "evidence": [ { "id": "NP_001029766", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029766" } ] }, { "name": "zinc finger-containing ubiquitin peptidase 1", "type": "synonym", "evidence": [ { "id": "NP_001029766", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029766" } ] } ], "function": [ { "annotation": "Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress.", "evidence": [ { "database": "UniProtKB", "id": "Q3SWY8", "url": "https://www.uniprot.org/uniprotkb/Q3SWY8#function" }, { "database": "UniProtKB", "id": "Q96AP4", "url": "https://www.uniprot.org/uniprotkb/Q96AP4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SWY8", "url": "https://www.uniprot.org/uniprotkb/Q3SWY8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZUP1", "url": "https://www.uniprot.org/uniprotkb/Q3SWY8", "locus": { "chromosome": "9", "start_pos": 33949379, "end_pos": 33924603, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003878", "url": "https://www.ensembl.org/id/ENSBTAG00000003878" } ] } } ], "crossref": [ { "id": "Q3SWY8", "url": "https://alphafold.ebi.ac.uk/entry/Q3SWY8", "database": "AlphaFoldDB", "categories": [] }, { "id": "533724", "url": "https://www.ncbi.nlm.nih.gov/gene/533724", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012462", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012462", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050688", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050688", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533724", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533724", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SWY8", "url": "https://www.orthodb.org/?gene=Q3SWY8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24403", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24403", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24403:SF82", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24403:SF82", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07910", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07910", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029766", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SWY8", "url": "https://www.uniprot.org/uniprotkb/Q3SWY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SWY8-1", "url": "https://www.uniprot.org/uniprotkb/Q3SWY8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSCDICGETVSSEPDMKAHLLIVHMENEVICPFCKLSGVNYDEMCFHIETAHFEQNELERNFERINTVQYGISDNRKDSSLQCRADINSSVHSACASNQPKISAQSLPKDGTLKHKDFYSENLTESRKFLKSTEKQSDRTKIKESIYETMYSPPECPFCGKIEDNSQDMETHVKTKHADLLDTPLEDCNQLLYDCPMCGLVCTNYHILQEHVDLHLEESSFGQGVNRVQCSRDLELAQQLQQEEDRKRRSEESRQEMEEFQKLQRQYGLDNSGGYKQQQLRNMEIEVNRGRMHPSEFHRRKADMMESLAIGVDDGKTKTSGIMEALYRYYQNAATDVRRVWLSAGVDHFHSSFGDKGWGCGYRNFQMLLSSLLQNDAYDDSLKGMSVPCIPKIQSMIEDAWKEGFDPQGASQLNDKLQGTKAWIGACEIYTLLTSLRIKCRIVDFHKSTGPLGTHPRLFEWILSYYASEREGSPKVVCTSKPPIYLQHQGHSRTVVGIEEKKNRTLCLLVFDPGCPSREMQKLLKHDMEVSSLKQLRKFVGNLKHKQYQIVAVEGVLSSEEKIARRQASQVFTAEKIP", "length": 579, "header": "sp|Q3SWY8-1|ZUP1_BOVIN Isoform 1 of Zinc finger-containing ubiquitin peptidase 1 OS=Bos taurus OX=9913 GN=ZUP1 PE=2 SV=1 CANONICAL=Q3SWY8-1" }, "isoforms": [ { "isoform_ac": "Q3SWY8-1", "url": "https://www.uniprot.org/uniprotkb/Q3SWY8/entry#Q3SWY8-1", "sequence": { "sequence": 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} ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 504, "end_pos": 506, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SWY8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 579, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SWY8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SWY8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.19.12", "ec_name": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly 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"gene_names": [ { "name": "ECSIT", "type": "recommended", "evidence": [ { "id": "Q3SX05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX05" } ] }, { "name": "ECSIT", "type": "synonym", "evidence": [ { "id": "NP_001029458", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029458" } ] } ], "protein_names": [ { "name": "Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q3SX05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX05/entry#names_and_taxonomy" } ] }, { "name": "ECSIT homolog", "type": "synonym", "evidence": [ { "id": "NP_001029458", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029458" } ] }, { "name": "ECSIT signalling integrator", "type": "synonym", "evidence": [ { "id": "NP_001029458", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029458" } ] }, { "name": "evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor", "type": "synonym", "evidence": [ { "id": "NP_001029458", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029458" } ] }, { "name": "evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001029458", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029458" } ] } ], "function": [ { "annotation": "Adapter protein that plays a role in different signaling pathways including TLRs and IL-1 pathways or innate antiviral induction signaling. Plays a role in the activation of NF-kappa-B by forming a signal complex with TRAF6 and TAK1/MAP3K7 to activate TAK1/MAP3K7 leading to activation of IKKs. Once ubiquitinated, interacts with the dissociated RELA and NFKB1 proteins and translocates to the nucleus where it induces NF-kappa-B-dependent gene expression. Plays a role in innate antiviral immune response by bridging the pattern recognition receptors RIGI and MDA5/IFIT1 to the MAVS complex at the mitochondrion (By similarity). Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SX05", "url": "https://www.uniprot.org/uniprotkb/Q3SX05#function" }, { "database": "UniProtKB", "id": "Q9BQ95", "url": "https://www.uniprot.org/uniprotkb/Q9BQ95#function" } ] }, { "annotation": "As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.", "evidence": [ { "database": "UniProtKB", "id": "Q3SX05", "url": "https://www.uniprot.org/uniprotkb/Q3SX05#function" }, { "database": "UniProtKB", "id": "Q9BQ95", "url": "https://www.uniprot.org/uniprotkb/Q9BQ95#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SX05", "url": "https://www.uniprot.org/uniprotkb/Q3SX05" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ECSIT", "url": "https://www.uniprot.org/uniprotkb/Q3SX05", "locus": { "chromosome": "7", "start_pos": 15862541, "end_pos": 15874330, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015049", "url": "https://www.ensembl.org/id/ENSBTAG00000015049" } ] } } ], "crossref": [ { "id": "Q3SX05", "url": "https://alphafold.ebi.ac.uk/entry/Q3SX05", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015049", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015049", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507245", "url": "https://www.ncbi.nlm.nih.gov/gene/507245", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029342", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029342", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046448", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046448", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507245", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507245", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GPFHIWL", "url": "https://omabrowser.org/oma/group/GPFHIWL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SX05", "url": "https://www.orthodb.org/?gene=Q3SX05", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13113", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13113", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13113:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13113:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06239", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06239", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14784", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14784", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-166058", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6799198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975138", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975138", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975871", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975871", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029458", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SX05", "url": 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"https://www.reactome.org/PathwayBrowser/#R-BTA-975871", "resource": "Reactome", "description": "MyD88 cascade initiated on plasma membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2R1W8-1", "protein_name": "Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial", "gene_name": "ECSIT", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSWAQAVLLARSLSRGWGGICSTALTGAPFSQVPLQAAHGLHCSTAMHTFDSSLVPHPPKPPRRPIKALALHEELFRKAPDGTREKASFVQAIQDFAQYNVHKRGHVDFIYLALRKMREYGVERDLAVYNLLLDIFPKEVFRPRSIFQTIFYHYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKYVRMKLWFTRFRNINPFPLPRDLPQDPVDLARLALRHMEPDLSARVTVYQMSLPEDSKDAVDPTEPHIVGIQSPDQQAALACHDPARPIFVEGPFSLWLRDKCVYYHILRADLLPPEERKVEEIPEEWSLYYPMQLDLAYERSGWDDYKFNINEVEEGPVFAICMAGAHDQATLAKWIQGLQETNPALARIPVVFRLAGSAGELLASSSGPEGSSPPPSEGQEEEDDNQQRQQQGQS", "length": 433 }, "evidence": [ { "id": "Q3SX05", "url": "https://omabrowser.org/oma/group/Q3SX05/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7GY04-1", "protein_name": "Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial", "gene_name": "Ecsit", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGWVQASLLVRGLSRGWGSICSTALSRAATTQVSLQAPRGLHCSAVIHKDDVSLVPRPPEPQRKPIKVPVLHEELFTPSATGEKDKASFLRALRSFEEHSVRKRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFPKEIFRPRNIIQRIFVHYPRQQECGISVLEQMERYAQVDLELLCCGAKPVLGLLIYVSSRPECWDYSSFICTGVMPNTETEFLLTQIFGRTSYPMLKFLRMKLWLTRFKNINPYPVPRDLPQDPLDLAKLSLRRMEPDLSAKVTVYQMSLPSDSTGTDPIQPHIVGIQSPDQQAALARHNPSKPVFVEGPFPLWLRNKCVYYHILRADLPLPEEEKVEEIPEEWNLYYPMKLDLEYSRSGWDNYEFDLDEVTEGPVFAMCMAGAHDQATLVKWIQGLQETNPILAQVPVVFRLARSTGELLTTSRLEEQSPPHGSPRDQEEDALQAQPQQG", "length": 467 }, "evidence": [ { "id": "Q3SX05", "url": "https://omabrowser.org/oma/group/Q3SX05/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q08CK1-1", "protein_name": "Evolutionarily conserved signaling intermediate in 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"MSWVQVNLLARGLSRGWGSICRTVLSGTPFAQPSLQARGLHCSAVTHKDDVWLVPRPSEPQKKPIKVPAMHEDLFRPSGNGEQDKASFLNAVRSFGEHNVRKRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFPKEVFRPRNAIQRIFVHYPRQQECGVAVLEQMERHGVMPNTETEFLLIQVFGHKSYPMLKFLRMKLWFTRFKNINPYPVPRDLPQDPLDLAKLGLRHMEPDLSAKVTVYQMSLPSESTGIEDPTQPHIVGIQSPDQQAALARHNPSRPVFVEGPFPLWLRNKCVYYHILRADLPPPEEETVEEIPEEWNLYYPMQLDLEYSRSAWDNYEFDMDEVTEGPVFAMCMTGAHDQATLVKWIQGLQETNPTLAQIPVVFRLARSTGELLATTRLEGQSPPHSPPKGPEEDDEAIQAQQRQGQS", "length": 434 }, "evidence": [ { "id": "Q3SX05", "url": "https://omabrowser.org/oma/group/Q3SX05/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9BQ95-1", "protein_name": "Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial", "gene_name": "ECSIT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSWVQATLLARGLCRAWGGTCGAALTGTSISQVPRRLPRGLHCSAAAHSSEQSLVPSPPEPRQRPTKALVPFEDLFGQAPGGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREYGVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSARVTIYQVPLPKDSTGAADPPQPHIVGIQSPDQQAALARHNPARPVFVEGPFSLWLRNKCVYYHILRADLLPPEEREVEETPEEWNLYYPMQLDLEYVRSGWDNYEFDINEVEEGPVFAMCMAGAHDQATMAKWIQGLQETNPTLAQIPVVFRLAGSTRELQTSSAGLEEPPLPEDHQEEDDNLQRQQQGQS", "length": 431 }, "evidence": [ { "id": "Q3SX05", "url": "https://omabrowser.org/oma/group/Q3SX05/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QZH6-1", "protein_name": "Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial", "gene_name": "Ecsit", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0004857", "evidence": [ { "database": "UniProtKB", "id": "Q3SX05", "url": "https://www.uniprot.org/uniprotkb/Q3SX05" } ], "pmid": "" }, { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "Q3SX05", "url": "https://www.uniprot.org/uniprotkb/Q3SX05" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3SX05", "url": "https://www.uniprot.org/uniprotkb/Q3SX05" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3SX05", "url": "https://www.uniprot.org/uniprotkb/Q3SX05" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SX05", "url": "https://www.uniprot.org/uniprotkb/Q3SX05" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3SX05", "url": "https://www.uniprot.org/uniprotkb/Q3SX05" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3SX05", "url": "https://www.uniprot.org/uniprotkb/Q3SX05" } ], "pmid": "" }, { "name": "mitochondrial complex I intermediate assembly complex", "id": "GO:0160295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160295", "evidence": [ { "database": "UniProtKB", "id": "Q3SX05", "url": "https://www.uniprot.org/uniprotkb/Q3SX05" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "Q3SX05", "url": "https://www.uniprot.org/uniprotkb/Q3SX05" } ], "pmid": "" }, { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "Q3SX05", "url": "https://www.uniprot.org/uniprotkb/Q3SX05" } ], "pmid": "" }, { "name": "cell surface receptor protein serine/threonine kinase signaling pathway", "id": "GO:0007178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007178", "evidence": [ { "database": "UniProtKB", "id": "Q3SX05", "url": "https://www.uniprot.org/uniprotkb/Q3SX05" } ], "pmid": "" }, { "name": "toll-like receptor 4 signaling pathway", "id": "GO:0034142", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034142", "evidence": [ { "database": "UniProtKB", "id": "Q3SX05", "url": "https://www.uniprot.org/uniprotkb/Q3SX05" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 95, "end_pos": 97, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SX05-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 433, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SX05-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SX05" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 95, "end_pos": 97 } ] }, "class_list": [], 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { 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"total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SX07-1", "uniprot_ac": "Q3SX07", "uniprot_id": "PUS3_BOVIN", "mass": { "chemical_mass": 55665.0, "monoisotopic_mass": 55665.0 }, "refseq": { "ac": "NP_001029684", "name": "tRNA pseudouridine(38/39) synthase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029684" }, "gene_names": [ { "name": "PUS3", "type": "recommended", "evidence": [ { "id": "Q3SX07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX07" } ] }, { "name": "PUS3", "type": "synonym", "evidence": [ { "id": "NP_001029684", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029684" } ] } ], "protein_names": [ { "name": "tRNA pseudouridine(38/39) synthase", "type": "recommended", "evidence": [ { "id": "Q3SX07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX07/entry#names_and_taxonomy" } ] }, { "name": "5.4.99.45", "type": "synonym", "evidence": [ { "id": 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"https://www.uniprot.org/uniprotkb/Q3SX07", "locus": { "chromosome": "29", "start_pos": 29247986, "end_pos": 29250458, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014339", "url": "https://www.ensembl.org/id/ENSBTAG00000014339" } ] } } ], "crossref": [ { "id": "Q3SX07", "url": "https://alphafold.ebi.ac.uk/entry/Q3SX07", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02569", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02569", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515824", "url": "https://www.ncbi.nlm.nih.gov/gene/515824", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001406", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001406", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020094", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020094", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041707", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041707", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515824", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515824", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SX07", "url": "https://www.orthodb.org/?gene=Q3SX07", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11142", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11142", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11142:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11142:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01416", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01416", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029684", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029684", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "42564", "url": "https://www.rhea-db.org/rhea/42564", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SX07", "url": "https://www.uniprot.org/uniprotkb/Q3SX07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SX07-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX07-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAENDVDRIQTEKLLKRVQELEQEVKRLKKEQANNKDSNIRENSSGAGGKPKRAFDFSAHGQRHVALKIAYLGWGYQGFASQENTSNTIEEKLFEALTKTRLVENRQTSNYHRCGRTDKGVSAFGQVISLDLRSHIPKGRDSEHFNLKNEVNDVATEIRYTHILNRVLPPDIRVLAWAPVETSFSARFSCLERTYRYFFPRANLDIVTMNYAAQKYVGTHDFRNLCKMDVANGVINFQRTILSAQVQRVGQNLGEEGWQEPFQLCQFEVTGQAFLYHQVRCMMAVLFLIGQGMEKPEVIDELLNIEKNPQKPQYSMAVEFPLVLYDCKFENIKWIYDREVQEFNVTHLQQLWANHAVKTQMLYSMLQGLDSVALPCGTGPKMDGMIEWRNVKPSVTKQTSAFVEGVKMRTYKPLMDRPKCQGLESRIQHFVRRGRIEHPHLFHEEETKAKRDCSDTLEEENTVFEKPMKRICVDTELKSII", "length": 481, "header": "sp|Q3SX07-1|PUS3_BOVIN Isoform 1 of tRNA pseudouridine(38/39) synthase OS=Bos taurus OX=9913 GN=PUS3 PE=2 SV=1 CANONICAL=Q3SX07-1" }, "isoforms": [ { "isoform_ac": "Q3SX07-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX07/entry#Q3SX07-1", "sequence": { "sequence": "MAENDVDRIQTEKLLKRVQELEQEVKRLKKEQANNKDSNIRENSSGAGGKPKRAFDFSAHGQRHVALKIAYLGWGYQGFASQENTSNTIEEKLFEALTKTRLVENRQTSNYHRCGRTDKGVSAFGQVISLDLRSHIPKGRDSEHFNLKNEVNDVATEIRYTHILNRVLPPDIRVLAWAPVETSFSARFSCLERTYRYFFPRANLDIVTMNYAAQKYVGTHDFRNLCKMDVANGVINFQRTILSAQVQRVGQNLGEEGWQEPFQLCQFEVTGQAFLYHQVRCMMAVLFLIGQGMEKPEVIDELLNIEKNPQKPQYSMAVEFPLVLYDCKFENIKWIYDREVQEFNVTHLQQLWANHAVKTQMLYSMLQGLDSVALPCGTGPKMDGMIEWRNVKPSVTKQTSAFVEGVKMRTYKPLMDRPKCQGLESRIQHFVRRGRIEHPHLFHEEETKAKRDCSDTLEEENTVFEKPMKRICVDTELKSII", "length": 481, "header": "sp|Q3SX07-1|PUS3_BOVIN Isoform 1 of tRNA pseudouridine(38/39) synthase OS=Bos taurus OX=9913 GN=PUS3 PE=2 SV=1 CANONICAL=Q3SX07-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 456, "end_pos": 456, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3SX07", "url": "https://www.uniprot.org/uniprotkb/Q3SX07" } ], "site_lbl": "Thr456" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:515824", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515824", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "tRNA pseudouridine synthesis", "id": "GO:0031119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031119", "evidence": [ { "database": "UniProtKB", "id": "Q3SX07", "url": "https://www.uniprot.org/uniprotkb/Q3SX07" } ], "pmid": "" }, { "name": "mRNA pseudouridine synthesis", "id": "GO:1990481", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990481", "evidence": [ { "database": "UniProtKB", "id": "Q3SX07", "url": "https://www.uniprot.org/uniprotkb/Q3SX07" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q3SX07", "url": "https://www.uniprot.org/uniprotkb/Q3SX07" } ], "pmid": "" }, { "name": "pseudouridine synthase activity", "id": "GO:0009982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009982", "evidence": [ { "database": "UniProtKB", "id": "Q3SX07", "url": "https://www.uniprot.org/uniprotkb/Q3SX07" } ], "pmid": "" }, { "name": "tRNA pseudouridine(38/39) synthase activity", "id": "GO:0160154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160154", "evidence": [ { "database": "UniProtKB", "id": "Q3SX07", "url": "https://www.uniprot.org/uniprotkb/Q3SX07" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3SX07", "url": "https://www.uniprot.org/uniprotkb/Q3SX07" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SX07", "url": "https://www.uniprot.org/uniprotkb/Q3SX07" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 344, "end_pos": 346, "annotation": "n_glycosylation_sequon" }, { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "42564", "name": "", "equation": "uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3SX07-1", "F1N5P3-1" ], "evidence": [ { "id": "42564", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42564" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1N5P3", "gene_name": "PUS3", "activity": [ { "ec_number": "5.4.99.45", "activity": "uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA.", "evidence": [ { "id": "F1N5P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5P3" } ] }, { "ec_number": "5.4.99.45", "activity": "", "evidence": [ { "id": "F1N5P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5P3" } ] } ] }, { "uniprot_ac": "Q3SX07", "gene_name": "PUS3", "activity": [ { "ec_number": "5.4.99.45", "activity": "uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA.", "evidence": [ { "id": "Q3SX07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX07" } ] }, { "ec_number": "5.4.99.45", "activity": "", "evidence": [ { "id": "Q3SX07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX07" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SX07-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 481, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SX07-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SX07" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "5.4.99.45", "ec_name": "uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA.", "evidence": [ { "id": "5.4.99.45", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.45" }, { "id": "5.4.99.45", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=5.4.99.45" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 456 ], "sequon_annotation_sites": [ { "start_pos": 344, "end_pos": 346 }, { "start_pos": 43, "end_pos": 45 }, { "start_pos": 84, "end_pos": 86 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"uniprot_canonical_ac": "Q3SX24-1", "uniprot_ac": "Q3SX24", "uniprot_id": "FBX6_BOVIN", "mass": { "chemical_mass": 30767.0, "monoisotopic_mass": 30767.0 }, "refseq": { "ac": "NP_001029605", "name": "F-box only protein 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029605" }, "gene_names": [ { "name": "FBXO6", "type": "recommended", "evidence": [ { "id": "Q3SX24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX24" } ] }, { "name": "FBS2", "type": "synonym", "evidence": [ { "id": "Q3SX24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX24" } ] }, { "name": "FBX6", "type": "synonym", "evidence": [ { "id": "Q3SX24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX24" } ] }, { "name": "FBXO6", "type": "synonym", "evidence": [ { "id": "NP_001029605", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029605" } ] } ], "protein_names": [ { "name": "F-box only protein 6", "type": "recommended", "evidence": [ { "id": "Q3SX24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX24/entry#names_and_taxonomy" } ] }, { "name": "F-box only protein 6", "type": "synonym", "evidence": [ { "id": "NP_001029605", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029605" } ] }, { "name": "F-box protein that recognizes sugar chains 2", "type": "synonym", "evidence": [ { "id": "NP_001029605", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029605" }, { "id": "Q3SX24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX24/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to ensure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SX24", "url": "https://www.uniprot.org/uniprotkb/Q3SX24#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SX24", "url": "https://www.uniprot.org/uniprotkb/Q3SX24" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO6", "url": "https://www.uniprot.org/uniprotkb/Q3SX24", "locus": { "chromosome": "16", "start_pos": 42003247, "end_pos": 42008040, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014777", "url": "https://www.ensembl.org/id/ENSBTAG00000014777" } ] } } ], "crossref": [ { "id": "Q3SX24", "url": "https://alphafold.ebi.ac.uk/entry/Q3SX24", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014777", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014777", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22168", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22168", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513023", "url": "https://www.ncbi.nlm.nih.gov/gene/513023", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "8ZUH", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8ZUH&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007397", "url": 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"PTHR12125", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12125", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12125:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12125:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00008zuh", "url": "https://www.rcsb.org/structure/pdb_00008zuh", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8ZUH", "url": "https://www.rcsb.org/structure/8ZUH", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF04300", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04300", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029605", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0P2C7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2C7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SX24", "url": "https://www.uniprot.org/uniprotkb/Q3SX24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SX24-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX24-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALVSINQLPENILLEVFMHVPARQLLRNCRPVCCLWRDLIDLVSLWKRKCLREGYVTEDWDQPVSDWKVFYFLCSLRRNLLRNPCAEEDMKSWKIDSNGGDQWKVESLPGAHGTGFPDSKVKKYFVTSYDMCLKSQIIDLKAEGYWEELLDKFRPDIVVKDWFAPRADCGCTYQIRVQLASADYLVLASFEPPPVTIHQWNDAKWTEVSHTFSDYPPGVRHIFFQHGGKDTQFWAGWYGPRVTNSSVVISHRVTRNPPHAMAQP", "length": 265, "header": "sp|Q3SX24-1|FBX6_BOVIN Isoform 1 of F-box only protein 6 OS=Bos taurus OX=9913 GN=FBXO6 PE=1 SV=1 CANONICAL=Q3SX24-1" }, "isoforms": [ { "isoform_ac": "A0ABI0P2C7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX24/entry#A0ABI0P2C7-1", "sequence": { "sequence": "MALVSINQLPENILLEVFMHVPARQLLRNCRPVCCLWRDLIDLVSLWKRKCLREGYVTEDWDQPVSDWKVFYFLCSLRRNLLRNPCAEEDMKSWKIDSNGGDQWKVESLPGAHGTGFPDSKVKKYFVTSYDMCLKSQIIDLKAEGYWEELLDKFRPDIVVKDWFAPRADCGCTYQIRVQLASADYLVLASFEPPPVTIHQWNDAKWTEVRPHLLAPRHLLLPRPGWQEIRGSPRAQNAPVHCLELLPSGREALPCRTWLHPSLPQLSHHHFSSPSDCSLSPPPRFPTPSRITLQESATSSFSTGARTPSSGQAGMGPVSPTAALSSATG", "length": 329, "header": "tr|A0ABI0P2C7-1|A0ABI0P2C7_BOVIN Computationally mapped isoform of F-box protein 6 OS=Bos taurus OX=9913 GN=FBXO6 PE=4 SV=1 CANONICAL=Q3SX24-1" }, "locus": { "chromosome": "16", "start_pos": 42008008, "end_pos": 42003512, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000146525.1", "url": "https://www.ensembl.org/id/ENSBTAT00000146525.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105641.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105641.1" } ] } }, { "isoform_ac": "Q3SX24-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX24/entry#Q3SX24-1", "sequence": { "sequence": "MALVSINQLPENILLEVFMHVPARQLLRNCRPVCCLWRDLIDLVSLWKRKCLREGYVTEDWDQPVSDWKVFYFLCSLRRNLLRNPCAEEDMKSWKIDSNGGDQWKVESLPGAHGTGFPDSKVKKYFVTSYDMCLKSQIIDLKAEGYWEELLDKFRPDIVVKDWFAPRADCGCTYQIRVQLASADYLVLASFEPPPVTIHQWNDAKWTEVSHTFSDYPPGVRHIFFQHGGKDTQFWAGWYGPRVTNSSVVISHRVTRNPPHAMAQP", "length": 265, "header": "sp|Q3SX24-1|FBX6_BOVIN Isoform 1 of F-box only protein 6 OS=Bos taurus OX=9913 GN=FBXO6 PE=1 SV=1 CANONICAL=Q3SX24-1" }, "locus": { "chromosome": "16", "start_pos": 42008008, "end_pos": 42003477, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034170.6", "url": "https://www.ensembl.org/id/ENSBTAT00000034170.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034071.4", "url": "https://www.ensembl.org/id/ENSBTAP00000034071.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 251, "end_pos": 251, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SX24", "url": "https://www.uniprot.org/uniprotkb/Q3SX24" } ], "site_lbl": "Ser251" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q3SX24", "url": "https://www.uniprot.org/uniprotkb/Q3SX24" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:513023", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513023", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RF93-1", "protein_name": "F-box protein 6", "gene_name": "FBXO6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALVSINQLPESILLEVFTHLPARQLLLNCRPVCSLWRDLIDLVTLWKRKCLCEGFVAEDWDQPVADWKVFYFLCSLRRNLLRNPCAEDDMTSWKIDSNGGNHWKVESLPGAHGTDFPDSKVKKYFVTSYGMCLKSQLIDLKAEGYWEELLDKFRPDIVVKDWFAARADCGCTYHIRVQLASADYIVLASFEPPPVTIPQWNDARWTEVSHTFSDYPPGVRHILFQHGGKDTQYWAGWYGPRVTNSSIIVSHRMSRSPAPSVVQP", "length": 265 }, "evidence": [ { "id": "Q3SX24", "url": "https://omabrowser.org/oma/group/Q3SX24/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q923V4-1", "protein_name": "F-box only protein 6", "gene_name": "Fbxo6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVNINELPENILLELFTHVPAPQLLRNCRLVCSLWRDLIDVMTLWKRKSLREGFVTKDRDEPVDDWKIFYILCSLQRNLLRNPCAEENLRSWRIDSNGGDEWKVESLPGDHGTSFPDTKVKKYFVTSYGMCLKSQMVDLKAEGYSEKLLDTVRPDIVVKDWFAPRADCGCTYHLRVQLASADYIVLASFEPPPVTIEQWNDASWQEISHTFSNYPPGVRHILFQHGGKDTQFWKGWYGPRVTNSSIIVSHRTAKNPAPARTLPEEDTSNRRKILSFGSWEDLSP", "length": 284 }, "evidence": [ { "id": "Q3SX24", "url": "https://omabrowser.org/oma/group/Q3SX24/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NRD1-1", "protein_name": "F-box only protein 6", "gene_name": "FBXO6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDAPHSKAALDSINELPENILLELFTHVPARQLLLNCRLVCSLWRDLIDLMTLWKRKCLREGFITKDWDQPVADWKIFYFLRSLHRNLLRNPCAEEDMFAWQIDFNGGDRWKVESLPGAHGTDFPDPKVKKYFVTSYEMCLKSQLVDLVAEGYWEELLDTFRPDIVVKDWFAARADCGCTYQLKVQLASADYFVLASFEPPPVTIQQWNNATWTEVSYTFSDYPRGVRYILFQHGGRDTQYWAGWYGPRVTNSSIVVSPKMTRNQASSEAQPGQKHGQEEAAQSPYRAVVQIF", "length": 293 }, "evidence": [ { "id": "Q3SX24", "url": "https://omabrowser.org/oma/group/Q3SX24/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QZN4-1", "protein_name": "F-box only protein 6", "gene_name": "Fbxo6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVHINELPENILLELFIHIPAPQLLRNCRLVCRLWRDLIDVVSLWKRKSLREGFFTKDRCEPVEDWKVFYILCSLQRNLLRNPCAEENLSSWRIDSNGGDRWKVETLPGSCGTSFPDNKVKKYFVTSFEMCLKSQMVDLKAEGYCEELMDTFRPDIVVKDWVAPRADCGCTYQLRVQLASADYIVLASFEPPPVTFQQWNDAKWQEISHTFSDYPPGVRHILFQHGGQDTQFWKGWYGPRVTNSSIIISHRTAKNPPPARTLPEETVVIGRRRRASDSNTHEGFFWQGLWQRLRR", "length": 295 }, "evidence": [ { "id": "Q3SX24", "url": "https://omabrowser.org/oma/group/Q3SX24/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SX24", "url": "https://www.uniprot.org/uniprotkb/Q3SX24" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "Q3SX24", "url": "https://www.uniprot.org/uniprotkb/Q3SX24" } ], "pmid": "" }, { "name": "endoplasmic reticulum quality control compartment", "id": "GO:0044322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044322", "evidence": [ { "database": "UniProtKB", "id": "Q3SX24", "url": "https://www.uniprot.org/uniprotkb/Q3SX24" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "Q3SX24", "url": "https://www.uniprot.org/uniprotkb/Q3SX24" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q3SX24", "url": "https://www.uniprot.org/uniprotkb/Q3SX24" } ], "pmid": "" }, { "name": "ERAD pathway", "id": "GO:0036503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503", "evidence": [ { "database": "UniProtKB", "id": "Q3SX24", "url": "https://www.uniprot.org/uniprotkb/Q3SX24" } ], "pmid": "" }, { "name": "response to unfolded protein", "id": "GO:0006986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006986", "evidence": [ { "database": "UniProtKB", "id": "Q3SX24", "url": "https://www.uniprot.org/uniprotkb/Q3SX24" } ], "pmid": "" }, { "name": "glycoprotein catabolic process", "id": "GO:0006516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006516", "evidence": [ { "database": "UniProtKB", "id": "Q3SX24", "url": "https://www.uniprot.org/uniprotkb/Q3SX24" } ], "pmid": "" }, { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "Q3SX24", "url": "https://www.uniprot.org/uniprotkb/Q3SX24" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SX24-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 265, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SX24-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SX24" }, { "pdb_id": "8zuh", "pdb_chain": "a/c", "start_pos": 1, "end_pos": 265, "overlap": "1.0", "method": "X-Ray_Crystallography", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/8zuh.pdb", "url_external": "https://www.rcsb.org/structure/8zuh" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SX24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX24" }, { "id": "PRU00080", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00080" } ], "ann_type": 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"evidence": [ { "id": "Q3SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX42/entry#names_and_taxonomy" } ] }, { "name": "CHMP2b", "type": "synonym", "evidence": [ { "id": "Q3SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX42/entry#names_and_taxonomy" } ] }, { "name": "Chromatin-modifying protein 2b", "type": "synonym", "evidence": [ { "id": "Q3SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX42/entry#names_and_taxonomy" } ] }, { "name": "charged multivesicular body protein 2b", "type": "synonym", "evidence": [ { "id": "NP_001030549", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030549" } ] }, { "name": "chromatin modifying protein 2B", "type": "synonym", "evidence": [ { "id": "NP_001030549", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030549" } ] }, { "name": "chromatin-modifying protein 2b", "type": "synonym", "evidence": [ { "id": "NP_001030549", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030549" } ] } ], "function": [ { "annotation": "Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SX42", "url": "https://www.uniprot.org/uniprotkb/Q3SX42#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SX42", "url": "https://www.uniprot.org/uniprotkb/Q3SX42" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHMP2B", "url": "https://www.uniprot.org/uniprotkb/Q3SX42", "locus": {} } ], "crossref": [ { "id": "Q3SX42", "url": "https://alphafold.ebi.ac.uk/entry/Q3SX42", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007939", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007939", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615954", "url": "https://www.ncbi.nlm.nih.gov/gene/615954", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615954", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615954", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QDMFEDD", "url": "https://omabrowser.org/oma/group/QDMFEDD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SX42", "url": "https://www.orthodb.org/?gene=Q3SX42", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10476", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10476", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03357", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03357", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1632852", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5620971", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620971", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-917729", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-917729", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9668328", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9668328", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030549", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NRY8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRY8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRY8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P677", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P677", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P677-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P677-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SX42", "url": "https://www.uniprot.org/uniprotkb/Q3SX42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SX42-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX42-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACRVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTSKSTISDEEIERQLKALGVD", "length": 213, "header": "sp|Q3SX42-1|CHM2B_BOVIN Isoform 1 of Charged multivesicular body protein 2b OS=Bos taurus OX=9913 GN=CHMP2B PE=2 SV=1 CANONICAL=Q3SX42-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NRY8-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX42/entry#A0ABI0NRY8-1", "sequence": { "sequence": "MELEIKKMAKIGNKEACRVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTSKSTISDEEIERQLKALGVD", "length": 172, "header": "tr|A0ABI0NRY8-1|A0ABI0NRY8_BOVIN Computationally mapped isoform of Charged multivesicular body protein 2B OS=Bos taurus OX=9913 GN=CHMP2B PE=3 SV=1 CANONICAL=Q3SX42-1" }, "locus": { "chromosome": "1", "start_pos": 35413607, "end_pos": 35381528, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153845.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153845.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106625.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106625.1" } ] } }, { "isoform_ac": "A0ABI0P677-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX42/entry#A0ABI0P677-1", "sequence": { "sequence": "IFSILKQKNLTSYVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACRVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTSKSTISDEEIERQLKALGVD", "length": 214, "header": "tr|A0ABI0P677-1|A0ABI0P677_BOVIN Computationally mapped isoform of Charged multivesicular body protein 2B OS=Bos taurus OX=9913 GN=CHMP2B PE=3 SV=1 CANONICAL=Q3SX42-1" }, "locus": { "chromosome": "1", "start_pos": 35413607, "end_pos": 35398787, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154212.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154212.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107397.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107397.1" } ] } }, { "isoform_ac": "Q3SX42-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX42/entry#Q3SX42-1", "sequence": { "sequence": "MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACRVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTSKSTISDEEIERQLKALGVD", "length": 213, "header": "sp|Q3SX42-1|CHM2B_BOVIN Isoform 1 of Charged multivesicular body protein 2b OS=Bos taurus OX=9913 GN=CHMP2B PE=2 SV=1 CANONICAL=Q3SX42-1" }, "locus": { "chromosome": "1", "start_pos": 35413607, "end_pos": 35381497, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154772.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154772.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107148.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107148.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 199, "end_pos": 199, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SX42", "url": "https://www.uniprot.org/uniprotkb/Q3SX42" } ], "site_lbl": "Ser199" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615954", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615954", "resource": "KEGG Pathway" }, { "id": "R-BTA-1632852", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "resource": "Reactome", "description": "Macroautophagy" }, { "id": "R-BTA-5620971", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620971", "resource": "Reactome", "description": "Pyroptosis" }, { "id": "R-BTA-917729", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-917729", "resource": "Reactome", "description": "Endosomal Sorting Complex Required For Transport (ESCRT)" }, { "id": "R-BTA-9668328", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9668328", "resource": "Reactome", "description": "Sealing of the nuclear envelope (NE) by ESCRT-III" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XTN8-1", "protein_name": "Charged multivesicular body protein 2B", "gene_name": "CHMP2B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASLFKKKTVDDIIKEQNRELRGTQRTITRDRAALEKQEKQLELEIKKMAKTGNKEACKVLAKQLVQLRKQKNRTYAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDASDEEEESQDIVNQVLDEIGIEISGKMAKAPSAARGLPSASTSKAATISDEEIERQLKALGVD", "length": 214 }, "evidence": [ { "id": "Q3SX42", "url": "https://omabrowser.org/oma/group/Q3SX42/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B0UXH0-1", "protein_name": "Charged multivesicular body protein 2Ba", "gene_name": "chmp2ba", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MASLFKKKTVDDIIKEQSKELRGTQRQITRDRAALERQERQMEMEIKKMAKTGNREACKILAKQLVQLRKQKNRTYAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQTVNKRMDPKKTLQTMQDFQKENMKMGMTEDMLNSTLDEIFDESADEEECQDIVNQVLDEIGIEISGKMVRAPSTGKILPGASPAKSKTATISDAEIERQLKALGMD", "length": 216 }, "evidence": [ { "id": "Q3SX42", "url": "https://omabrowser.org/oma/group/Q3SX42/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q0WTY4-1", "protein_name": "Vacuolar protein sorting-associated protein 2 homolog 2", "gene_name": "VPS2.2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MNIFKKKTTPKDALRTSKREMAVATRGIEREITSLQLEEKRLVAEIKKTAKTGNEAATKILARQLVRLRQQITNLQGSRAQIRGVTTHTQALYASTSISSGMKGATKAMVAMNKQMAPTKQAKVIKDFQKQSAQLDMTIEMMSEAIDETLDKDEAEEETEDLTNQVLDEIGVGVASQLSSAPKGRIATKTAAPPASTAATNKNSESSEVDELEKRLASLRRI", "length": 222 }, "evidence": [ { "id": "Q3SX42", "url": "https://omabrowser.org/oma/group/Q3SX42/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q54GK9-1", "protein_name": "Charged multivesicular body protein 2a homolog 1", "gene_name": "chmp2a1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSFFGGNKKTPEQELKDSKRELSKGQREMDRELNRLKIVEQEYIGKIKQLAKAGRNDEAKRMANDLVKLRGQMERMRATKTTLSAVSTKTTTIKANQTMANAMASATKAMSTMNKQTDLVQLQKTMMEYEKQTQRVEMTEEMMQDMFEDDEVDEEADDILSKVVDEVCLDNYQKMPSVAQKDLPYSSKTSTFKTEDEELNKLLQSL", "length": 206 }, "evidence": [ { "id": "Q3SX42", "url": "https://omabrowser.org/oma/group/Q3SX42/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "ESCRT III complex", "id": "GO:0000815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000815", "evidence": [ { "database": "UniProtKB", "id": "Q3SX42", "url": "https://www.uniprot.org/uniprotkb/Q3SX42" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3SX42", "url": "https://www.uniprot.org/uniprotkb/Q3SX42" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "Q3SX42", "url": "https://www.uniprot.org/uniprotkb/Q3SX42" } ], "pmid": "" }, { "name": "multivesicular body", "id": "GO:0005771", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005771", "evidence": [ { "database": "UniProtKB", "id": "Q3SX42", "url": "https://www.uniprot.org/uniprotkb/Q3SX42" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q3SX42", "url": "https://www.uniprot.org/uniprotkb/Q3SX42" } ], "pmid": "" }, { "name": "late endosome to vacuole transport", "id": "GO:0045324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045324", "evidence": [ { "database": "UniProtKB", "id": "Q3SX42", "url": "https://www.uniprot.org/uniprotkb/Q3SX42" } ], "pmid": "" }, { "name": "endosome transport via multivesicular body sorting pathway", "id": "GO:0032509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032509", "evidence": [ { "database": "UniProtKB", "id": "Q3SX42", "url": "https://www.uniprot.org/uniprotkb/Q3SX42" } ], "pmid": "" }, { "name": "vacuolar transport", "id": "GO:0007034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007034", "evidence": [ { "database": "UniProtKB", "id": "Q3SX42", "url": "https://www.uniprot.org/uniprotkb/Q3SX42" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 143, "end_pos": 145, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SX42-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 213, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SX42-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SX42" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 199 ], "sequon_annotation_sites": [ { "start_pos": 143, "end_pos": 145 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SX44-1", "uniprot_ac": "Q3SX44", "uniprot_id": "DDAH2_BOVIN", "mass": { "chemical_mass": 29780.0, "monoisotopic_mass": 29780.0 }, "refseq": { "ac": "NP_001029876", "name": "putative hydrolase DDAH2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029876" }, "gene_names": [ { "name": "DDAH2", "type": "recommended", "evidence": [ { "id": "Q3SX44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX44" } ] }, { "name": "DDAH2", "type": "synonym", "evidence": [ { "id": "NP_001029876", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029876" } ] } ], "protein_names": [ { "name": "Putative hydrolase DDAH2", "type": "recommended", "evidence": [ { "id": "Q3SX44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX44/entry#names_and_taxonomy" } ] }, { "name": "3.-.-.-", "type": "synonym", "evidence": [ { "id": "Q3SX44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX44/entry#names_and_taxonomy" } ] }, { "name": "DDAH-2", "type": "synonym", "evidence": [ { "id": "NP_001029876", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029876" }, { "id": "Q3SX44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX44/entry#names_and_taxonomy" } ] }, { "name": "DDAHII", "type": "synonym", "evidence": [ { "id": "NP_001029876", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029876" }, { "id": "Q3SX44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX44/entry#names_and_taxonomy" } ] }, { "name": "Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2", "type": "synonym", "evidence": [ { "id": "Q3SX44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX44/entry#names_and_taxonomy" } ] }, { "name": "Inactive dimethylarginine dimethylaminohydrolase 2", "type": "synonym", "evidence": [ { "id": "Q3SX44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX44/entry#names_and_taxonomy" } ] }, { "name": "dimethylargininase-2", "type": "synonym", "evidence": [ { "id": "NP_001029876", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029876" } ] }, { "name": "inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2", "type": "synonym", "evidence": [ { "id": "NP_001029876", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029876" } ] }, { "name": "inactive dimethylarginine dimethylaminohydrolase 2", "type": "synonym", "evidence": [ { "id": "NP_001029876", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029876" } ] }, { "name": "n(G),N(G)-dimethylarginine dimethylaminohydrolase 2", "type": "synonym", "evidence": [ { "id": "NP_001029876", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029876" } ] }, { "name": "putative hydrolase DDAH2", "type": "synonym", "evidence": [ { "id": "NP_001029876", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029876" } ] } ], "function": [ { "annotation": "Putative hydrolase with unknown substrate. Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (By similarity). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase. Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SX44", "url": "https://www.uniprot.org/uniprotkb/Q3SX44#function" }, { "database": "UniProtKB", "id": "O95865", "url": "https://www.uniprot.org/uniprotkb/O95865#function" }, { "database": "UniProtKB", "id": "Q99LD8", "url": "https://www.uniprot.org/uniprotkb/Q99LD8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SX44", "url": "https://www.uniprot.org/uniprotkb/Q3SX44" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DDAH2", "url": "https://www.uniprot.org/uniprotkb/Q3SX44", "locus": { "chromosome": "23", "start_pos": 27585128, "end_pos": 27581609, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013530", "url": "https://www.ensembl.org/id/ENSBTAG00000013530" } ] } } ], "crossref": [ { "id": "Q3SX44", "url": "https://alphafold.ebi.ac.uk/entry/Q3SX44", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013530", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013530", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "3.5.3.18", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.5.3.18&UniProtAcc=Q3SX44", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "540386", "url": "https://www.ncbi.nlm.nih.gov/gene/540386", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR033199", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033199", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540386", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540386", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KNVCSMG", "url": "https://omabrowser.org/oma/group/KNVCSMG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SX44", "url": "https://www.orthodb.org/?gene=Q3SX44", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12737", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12737", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12737:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12737:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001029876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029876", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SX44", "url": "https://www.uniprot.org/uniprotkb/Q3SX44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SX44-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX44-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTPGEGLGRCSHALIRGVPESLASGEGAAAGLPALDLAKAQREHGVLGGKLRQRLGLQLVELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEMGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVTSTSHLRGLCGMGGPRTVVAGSSEAAQKAVRAMAVLTDHPYASLTLPDDAAADCLFLRPGQPGLPPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLCLVLSTRPHN", "length": 285, "header": "sp|Q3SX44-1|DDAH2_BOVIN Isoform 1 of Putative hydrolase DDAH2 OS=Bos taurus OX=9913 GN=DDAH2 PE=2 SV=1 CANONICAL=Q3SX44-1" }, "isoforms": [ { "isoform_ac": "Q3SX44-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX44/entry#Q3SX44-1", "sequence": { "sequence": "MGTPGEGLGRCSHALIRGVPESLASGEGAAAGLPALDLAKAQREHGVLGGKLRQRLGLQLVELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEMGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVTSTSHLRGLCGMGGPRTVVAGSSEAAQKAVRAMAVLTDHPYASLTLPDDAAADCLFLRPGQPGLPPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLCLVLSTRPHN", "length": 285, "header": "sp|Q3SX44-1|DDAH2_BOVIN Isoform 1 of Putative hydrolase DDAH2 OS=Bos taurus OX=9913 GN=DDAH2 PE=2 SV=1 CANONICAL=Q3SX44-1" }, "locus": { "chromosome": "23", "start_pos": 27584928, "end_pos": 27582691, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017991.4", "url": "https://www.ensembl.org/id/ENSBTAT00000017991.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017991.2", "url": "https://www.ensembl.org/id/ENSBTAP00000017991.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:540386", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540386", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A5S7-1", "protein_name": "DDAH family member 2, ADMA-independent", "gene_name": "DDAH2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGTPGEGLGRCSHALIRGVPESLASVEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEMGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGPSHLRGLCGMGGPRTVVAGSSEAAQKAVRAMAVLTDHPYASLTLPDDAAADCLFLRPGLPGVPPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLCLVLSTRPHS", "length": 285 }, "evidence": [ { "id": "Q3SX44", "url": "https://omabrowser.org/oma/group/Q3SX44/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6MG60-1", "protein_name": "Putative hydrolase DDAH2", "gene_name": "Ddah2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEMGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGASHLRGLCGMGGPRTVVAGSSEAAQKAVRAMAALTDHPYASLTLPDDAASDCLFLRPGLPGTTPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKVGAGLSSLCLVLSTRPHC", "length": 285 }, "evidence": [ { "id": "Q3SX44", "url": "https://omabrowser.org/oma/group/Q3SX44/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99LD8-1", "protein_name": "Putative hydrolase DDAH2", "gene_name": "Ddah2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEMGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGSSHLRGLCGMGGPRTVVAGSSEAAQKAVRAMAALTDHPYASLTLPDDAASDCLFLRPGLPGATPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLCLVLSTRPHC", "length": 285 }, "evidence": [ { "id": "Q3SX44", "url": "https://omabrowser.org/oma/group/Q3SX44/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3SX44", "url": "https://www.uniprot.org/uniprotkb/Q3SX44" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "Q3SX44", "url": "https://www.uniprot.org/uniprotkb/Q3SX44" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of nitric oxide biosynthetic process", "id": "GO:0045429", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045429", "evidence": [ { "database": "UniProtKB", "id": "Q3SX44", "url": "https://www.uniprot.org/uniprotkb/Q3SX44" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SX44-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 285, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SX44-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SX44" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 121, "end_pos": 123 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SX45-1", "uniprot_ac": "Q3SX45", "uniprot_id": "ASB2_BOVIN", "mass": { "chemical_mass": 70219.0, "monoisotopic_mass": 70219.0 }, "refseq": { "ac": "NP_001029841", "name": "ankyrin repeat and SOCS box protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029841" }, "gene_names": [ { "name": "ASB2", "type": "recommended", "evidence": [ { "id": "Q3SX45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX45" } ] }, { "name": "ASB2", "type": "synonym", "evidence": [ { "id": "NP_001029841", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029841" } ] } ], "protein_names": [ { "name": "Ankyrin repeat and SOCS box protein 2", "type": "recommended", "evidence": [ { "id": "Q3SX45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX45/entry#names_and_taxonomy" } ] }, { "name": "ASB-2", "type": "synonym", "evidence": [ { "id": "NP_001029841", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029841" }, { "id": "Q3SX45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX45/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat and SOCS box protein 2", "type": "synonym", "evidence": [ { "id": "NP_001029841", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029841" } ] } ], "function": [ { "annotation": "Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Mediates Notch-induced ubiquitination and degradation of substrates including E2A and JAK2 (By similarity). Required during embryonic heart development for complete heart looping (By similarity). Required for cardiomyocyte differentiation (By similarity). Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA (By similarity). Also targets DES for proteasomal degradation (By similarity). Acts as a negative regulator of skeletal muscle mass (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SX45", "url": "https://www.uniprot.org/uniprotkb/Q3SX45#function" }, { "database": "UniProtKB", "id": "Q96Q27", "url": "https://www.uniprot.org/uniprotkb/Q96Q27#function" }, { "database": "UniProtKB", "id": "Q8K0L0", "url": "https://www.uniprot.org/uniprotkb/Q8K0L0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SX45", "url": "https://www.uniprot.org/uniprotkb/Q3SX45" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASB2", "url": "https://www.uniprot.org/uniprotkb/Q3SX45", "locus": { "chromosome": "21", "start_pos": 58530360, "end_pos": 58579232, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007109", "url": "https://www.ensembl.org/id/ENSBTAG00000007109" } ] } } ], "crossref": [ { "id": "Q3SX45", "url": "https://alphafold.ebi.ac.uk/entry/Q3SX45", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03721", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03721", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539244", "url": "https://www.ncbi.nlm.nih.gov/gene/539244", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539244", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539244", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SX45", "url": "https://www.orthodb.org/?gene=Q3SX45", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24171", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24171", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24171:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24171:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", 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"https://www.uniprot.org/uniprotkb/Q3SX45-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATEISARGRPRAIGQEEYNLYSSLSEDELVQMAIEQSLADKTRGPTTTETTVPTRVNREPAHFYPWTRSSVSPESALTSAPKGLFQEVMQKYNRSKSSQLAPVDPVLKAIKEDDEEALTAMIKAGKNLSEPNKEGWLPLHEAAYYGQLNCLKALHRAYPAVIDQRTLQEETALYLATCRGHVDCLQFLLQAGAEPDISNKSRETPLYKACERKNVEAVRILVQYKADTNHRCNRGWTALHESVARNDLEVMEILVSGGAKVEAKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDSASALYEACKNGHEEVVEFLLSQGADANKTNKDGMLPLHIASKKGNYRIVQMLLPVTSRTRVRRSGISPLHLAAERNNDEVLEALLGARFDVNAPLAPERARLYEDRRSSALYFAVVNNNVYATELLLLAGADPNRDVINPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCNGEPCFSCLYGNGPHPPAPPPSNRFNDAPASDKAPSAVQFCEFLSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ", "length": 633, "header": "sp|Q3SX45-1|ASB2_BOVIN Isoform 1 of Ankyrin repeat and SOCS box protein 2 OS=Bos taurus OX=9913 GN=ASB2 PE=2 SV=1 CANONICAL=Q3SX45-1" }, "isoforms": [ { "isoform_ac": "Q3SX45-1", "url": "https://www.uniprot.org/uniprotkb/Q3SX45/entry#Q3SX45-1", "sequence": { "sequence": "MATEISARGRPRAIGQEEYNLYSSLSEDELVQMAIEQSLADKTRGPTTTETTVPTRVNREPAHFYPWTRSSVSPESALTSAPKGLFQEVMQKYNRSKSSQLAPVDPVLKAIKEDDEEALTAMIKAGKNLSEPNKEGWLPLHEAAYYGQLNCLKALHRAYPAVIDQRTLQEETALYLATCRGHVDCLQFLLQAGAEPDISNKSRETPLYKACERKNVEAVRILVQYKADTNHRCNRGWTALHESVARNDLEVMEILVSGGAKVEAKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDSASALYEACKNGHEEVVEFLLSQGADANKTNKDGMLPLHIASKKGNYRIVQMLLPVTSRTRVRRSGISPLHLAAERNNDEVLEALLGARFDVNAPLAPERARLYEDRRSSALYFAVVNNNVYATELLLLAGADPNRDVINPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCNGEPCFSCLYGNGPHPPAPPPSNRFNDAPASDKAPSAVQFCEFLSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ", "length": 633, "header": "sp|Q3SX45-1|ASB2_BOVIN Isoform 1 of Ankyrin repeat and SOCS box protein 2 OS=Bos taurus OX=9913 GN=ASB2 PE=2 SV=1 CANONICAL=Q3SX45-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 369, "end_pos": 369, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SX45", "url": "https://www.uniprot.org/uniprotkb/Q3SX45" } ], "site_lbl": "Ser369" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539244", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539244", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "Q3SX45", "url": "https://www.uniprot.org/uniprotkb/Q3SX45" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "Q3SX45", "url": "https://www.uniprot.org/uniprotkb/Q3SX45" } ], "pmid": "" }, { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "Q3SX45", "url": "https://www.uniprot.org/uniprotkb/Q3SX45" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q3SX45", "url": "https://www.uniprot.org/uniprotkb/Q3SX45" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q3SX45", "url": "https://www.uniprot.org/uniprotkb/Q3SX45" } ], "pmid": "" }, { "name": "skeletal muscle atrophy", "id": "GO:0014732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014732", "evidence": [ { "database": "UniProtKB", "id": "Q3SX45", "url": "https://www.uniprot.org/uniprotkb/Q3SX45" } ], "pmid": "" }, { "name": "cardiac muscle cell differentiation", "id": "GO:0055007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055007", "evidence": [ { "database": "UniProtKB", "id": "Q3SX45", "url": "https://www.uniprot.org/uniprotkb/Q3SX45" } ], "pmid": "" }, { "name": "cardiac muscle cell development", "id": "GO:0055013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055013", "evidence": [ { "database": "UniProtKB", "id": "Q3SX45", "url": "https://www.uniprot.org/uniprotkb/Q3SX45" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "stress fiber", "id": "GO:0001725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001725", "evidence": [ { "database": "UniProtKB", "id": "Q3SX45", "url": "https://www.uniprot.org/uniprotkb/Q3SX45" } ], "pmid": "" }, { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "Q3SX45", "url": "https://www.uniprot.org/uniprotkb/Q3SX45" } ], "pmid": "" }, { "name": "ubiquitin ligase complex", "id": "GO:0000151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000151", "evidence": [ { "database": "UniProtKB", "id": "Q3SX45", "url": "https://www.uniprot.org/uniprotkb/Q3SX45" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 200, "end_pos": 202, "annotation": "n_glycosylation_sequon" }, { "start_pos": 329, "end_pos": 331, "annotation": "n_glycosylation_sequon" }, { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SX45-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 633, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SX45-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SX45" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SX45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX45" }, { "id": "PRU00194", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00194" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SOCS box", "eco_id": "ECO_0000255", "start_pos": 579, "end_pos": 633, "start_aa": "Glu", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SX45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX45" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UIM", "eco_id": "ECO_0000305", "start_pos": 26, "end_pos": 45, "start_aa": "Ser", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 369 ], "sequon_annotation_sites": [ { "start_pos": 128, "end_pos": 130 }, { "start_pos": 200, "end_pos": 202 }, { "start_pos": 329, "end_pos": 331 }, { "start_pos": 94, "end_pos": 96 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", 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0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SYR2-1", "uniprot_ac": "Q3SYR2", "uniprot_id": "U119A_BOVIN", "mass": { "chemical_mass": 26987.0, "monoisotopic_mass": 26987.0 }, "refseq": { "ac": "NP_001029817", "name": "protein unc-119 homolog A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029817" }, "gene_names": [ { "name": "UNC119", "type": "recommended", "evidence": [ { "id": "Q3SYR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYR2" } ] }, { "name": "UNC119", "type": "synonym", "evidence": [ { "id": "NP_001029817", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029817" } ] } ], "protein_names": [ { "name": "Protein unc-119 homolog A", "type": "recommended", "evidence": [ { "id": "Q3SYR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYR2/entry#names_and_taxonomy" } ] }, { "name": "protein unc-119 homolog A", "type": "synonym", "evidence": [ { "id": "NP_001029817", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029817" } ] }, { "name": "unc-119 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029817", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029817" } ] } ], "function": [ { "annotation": "Interaction of transducin with uncoordinated 119 protein (UNC119): implications for the model of transducin trafficking in rod photoreceptors.", "evidence": [ { "database": "RefSeq", "id": "NP_001029817", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029817" }, { "database": "PubMed", "id": "21712387", "url": "https://glygen.org/publication/PubMed/21712387" } ] }, { "annotation": "Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SYR2", "url": "https://www.uniprot.org/uniprotkb/Q3SYR2#function" }, { "database": "UniProtKB", "id": "Q9Z2R6", "url": "https://www.uniprot.org/uniprotkb/Q9Z2R6#function" }, { "database": "UniProtKB", "id": "Q13432", "url": "https://www.uniprot.org/uniprotkb/Q13432#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SYR2", "url": "https://www.uniprot.org/uniprotkb/Q3SYR2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UNC119", "url": "https://www.uniprot.org/uniprotkb/Q3SYR2", "locus": { "chromosome": "19", "start_pos": 20009078, "end_pos": 20015144, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013096", "url": "https://www.ensembl.org/id/ENSBTAG00000013096" } ] } } ], "crossref": [ { "id": "Q3SYR2", "url": "https://alphafold.ebi.ac.uk/entry/Q3SYR2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013096", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013096", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538501", "url": "https://www.ncbi.nlm.nih.gov/gene/538501", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008015", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008015", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538501", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538501", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CLVMHNK", "url": "https://omabrowser.org/oma/group/CLVMHNK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SYR2", "url": "https://www.orthodb.org/?gene=Q3SYR2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12951", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12951", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12951:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12951:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05351", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05351", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029817", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029817", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SYR2", "url": "https://www.uniprot.org/uniprotkb/Q3SYR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYR2-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYR2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKVKKGGGGAGTGAEHAPGASGPNVEPKPELQAESESGSESEPEAGPGPRPGPLQRKQPIGPEDVLGLQRITGDYLCSPEENIYKIDFVRFKIRDMDSGTVLFEIKKPPASERLPINPRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFRMIERHYFRNQLLKSFDFHFGFCIPSSKNTCEHIYDFPALSEELINEMIRHPYETQSDSFYFVDDRLVMHNKADYSYSGTP", "length": 240, "header": "sp|Q3SYR2-1|U119A_BOVIN Isoform 1 of Protein unc-119 homolog A OS=Bos taurus OX=9913 GN=UNC119 PE=2 SV=1 CANONICAL=Q3SYR2-1" }, "isoforms": [ { "isoform_ac": "Q3SYR2-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYR2/entry#Q3SYR2-1", "sequence": { "sequence": "MKVKKGGGGAGTGAEHAPGASGPNVEPKPELQAESESGSESEPEAGPGPRPGPLQRKQPIGPEDVLGLQRITGDYLCSPEENIYKIDFVRFKIRDMDSGTVLFEIKKPPASERLPINPRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFRMIERHYFRNQLLKSFDFHFGFCIPSSKNTCEHIYDFPALSEELINEMIRHPYETQSDSFYFVDDRLVMHNKADYSYSGTP", "length": 240, "header": "sp|Q3SYR2-1|U119A_BOVIN Isoform 1 of Protein unc-119 homolog A OS=Bos taurus OX=9913 GN=UNC119 PE=2 SV=1 CANONICAL=Q3SYR2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 37, "end_pos": 37, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CK2", "evidence": [ { "database": "UniProtKB", "id": "Q3SYR2", "url": "https://www.uniprot.org/uniprotkb/Q3SYR2" } ], "site_lbl": "Ser37" }, { "start_pos": 39, "end_pos": 39, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CK2", "evidence": [ { "database": "UniProtKB", "id": "Q3SYR2", "url": "https://www.uniprot.org/uniprotkb/Q3SYR2" } ], "site_lbl": "Ser39" }, { "start_pos": 41, "end_pos": 41, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CK2", "evidence": [ { "database": "UniProtKB", "id": "Q3SYR2", "url": "https://www.uniprot.org/uniprotkb/Q3SYR2" } ], "site_lbl": "Ser41" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Interaction of transducin with uncoordinated 119 protein (UNC119): implications for the model of transducin trafficking in rod photoreceptors.", "journal": "The Journal of biological chemistry", "date": "2011-08-19", "authors": "Gopalakrishna Kota N, Doddapuneni Krishnarao, Boyd Kimberly K, Masuho Ikuo, Martemyanov Kirill A, Artemyev Nikolai O", "evidence": [ { "database": "RefSeq", "id": "NP_001029817", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029817" } ], "reference": [ { "type": "PubMed", "id": "21712387", "url": "https://glygen.org/publication/PubMed/21712387" } ] } ], "pathway": [ { "id": "bta:538501", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538501", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q13432-1", "protein_name": "Protein unc-119 homolog A", "gene_name": "UNC119", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKVKKGGGGAGTATESAPGPSGQSVAPIPQPPAESESGSESEPDAGPGPRPGPLQRKQPIGPEDVLGLQRITGDYLCSPEENIYKIDFVRFKIRDMDSGTVLFEIKKPPVSERLPINRRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFRMIERHYFRNQLLKSFDFHFGFCIPSSKNTCEHIYDFPPLSEELISEMIRHPYETQSDSFYFVDDRLVMHNKADYSYSGTP", "length": 240 }, "evidence": [ { "id": "Q3SYR2", "url": "https://omabrowser.org/oma/group/Q3SYR2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q62885-1", "protein_name": "Protein unc-119 homolog A", "gene_name": "Unc119", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKVKKGGGGTGPGAEPVPGASNRSVEPTREPGAEAESGSESEPEPGPGPRLGPLQGKQPIGPEDVLGLQRITGDYLCSPEENIYKIDFVRFKIRDMDSGTVLFEIKKPPVSERLPINRRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFRMIERHYFRNQLLKSFDFHFGFCIPSSKNTCEHIYDFPPLSEELISEMIRHPYETQSDSFYFVDDRLVMHNKADYSYSGTP", "length": 240 }, "evidence": [ { "id": "Q3SYR2", "url": "https://omabrowser.org/oma/group/Q3SYR2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9XYQ2-1", "protein_name": "Protein unc-119 homolog", "gene_name": "unc-119", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSVVGKQLNPVQSSGAGAVTTSSSAAAGSSSSNSGVEANGGSGGSSGAAAAGAGASGDAKRPAESSSVTPDEVLHLTKITDDYLCSANANVFEIDFTRFKIRDLESGAVLFEIAKPPSEQYPEGLSSDETMLAAAEKLSLDDTADPNAGRYVRYQFTPAFLNLKTVGATVEFTVGSQPLNNFRMIERHFFRDRLLKTFDFEFGFCFPFSKNTVEHIYEFPNLPPDLVAEMISSPFETRSDSFYFVGNRLVMHNKADYAYDGGNIV", "length": 265 }, "evidence": [ { "id": "Q3SYR2", "url": "https://omabrowser.org/oma/group/Q3SYR2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Z2R6-1", "protein_name": "Protein unc-119 homolog A", "gene_name": "Unc119", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKVKKGGGGTGSGAEPVPGASNRSAEPTREPGAEAESGSESEPEPGPGPRLGPLQGKQPIGPEDVLGLQRITGDYLCSPEENIYKIDFVRFKIRDMDSGTVLFEIKKPPVSERLPINRRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFRMIERHYFRNQLLKSFDFHFGFCIPSSKNTCEHIYDFPPLSEELISEMIRHPYETQSDSFYFVDDRLVMHNKADYSYSGTP", "length": 240 }, "evidence": [ { "id": "Q3SYR2", "url": "https://omabrowser.org/oma/group/Q3SYR2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "Q3SYR2", "url": "https://www.uniprot.org/uniprotkb/Q3SYR2" } ], "pmid": "" }, { "name": "centrosome", 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"https://www.ebi.ac.uk/QuickGO/term/GO:2001287", "evidence": [ { "database": "UniProtKB", "id": "Q3SYR2", "url": "https://www.uniprot.org/uniprotkb/Q3SYR2" } ], "pmid": "" }, { "name": "negative regulation of clathrin-dependent endocytosis", "id": "GO:1900186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900186", "evidence": [ { "database": "UniProtKB", "id": "Q3SYR2", "url": "https://www.uniprot.org/uniprotkb/Q3SYR2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "Q3SYR2", "url": "https://www.uniprot.org/uniprotkb/Q3SYR2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SYR2-F1", "pdb_chain": "global", "start_pos": 1, 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"https://www.uniprot.org/uniprotkb/Q3SYS0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLSALLALASKVTLPPNYRYGMSRPGSLADKKKNPPGTRRRRVAVEPIPEEDWHLFCGDRVEILEGKDAGKQGKVVQVIRQRNWVVVEGLNTHYRYVGKTVDFRGTMVPSEAPLLHNQVKLVDPMDRKPTEVEWRFTEAGERVRVSTRSGRIIPKPDVPRADGIVPETWIDGPKDTSVEDALEKTYVPRLKTLEEEVMEAMGIQETRRHKKVYWY", "length": 216, "header": "sp|Q3SYS0-1|RM24_BOVIN Isoform 1 of Large ribosomal subunit protein uL24m OS=Bos taurus OX=9913 GN=MRPL24 PE=1 SV=1 CANONICAL=Q3SYS0-1" }, "isoforms": [ { "isoform_ac": "Q3SYS0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYS0/entry#Q3SYS0-1", "sequence": { "sequence": "MRLSALLALASKVTLPPNYRYGMSRPGSLADKKKNPPGTRRRRVAVEPIPEEDWHLFCGDRVEILEGKDAGKQGKVVQVIRQRNWVVVEGLNTHYRYVGKTVDFRGTMVPSEAPLLHNQVKLVDPMDRKPTEVEWRFTEAGERVRVSTRSGRIIPKPDVPRADGIVPETWIDGPKDTSVEDALEKTYVPRLKTLEEEVMEAMGIQETRRHKKVYWY", "length": 216, "header": "sp|Q3SYS0-1|RM24_BOVIN Isoform 1 of Large ribosomal subunit protein uL24m OS=Bos taurus OX=9913 GN=MRPL24 PE=1 SV=1 CANONICAL=Q3SYS0-1" }, "locus": { "chromosome": "3", "start_pos": 14098539, "end_pos": 14097251, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001991.5", "url": "https://www.ensembl.org/id/ENSBTAT00000001991.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001991.2", "url": "https://www.ensembl.org/id/ENSBTAP00000001991.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 24, "end_pos": 24, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS0", "url": "https://www.uniprot.org/uniprotkb/Q3SYS0" } ], "site_lbl": "Ser24" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Mammalian mitochondrial ribosomal proteins (4). Amino acid sequencing, characterization, and identification of corresponding gene sequences.", "journal": "J. Biol. Chem.", "date": "2000", "authors": "O'Brien TW, Liu J, Sylvester JE, Mougey EB, Fischel-Ghodsian N, Thiede B, Wittmann-Liebold B, Graack HR", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS0", "url": "https://www.uniprot.org/uniprotkb/Q3SYS0" } ], "reference": [ { "type": "PubMed", "id": "10751423", "url": "https://glygen.org/publication/PubMed/10751423" } ] }, { "title": "A structural model for the large subunit of the mammalian mitochondrial ribosome.", "journal": "J. Mol. Biol.", "date": "2006", "authors": "Mears Jason A, Sharma Manjuli R, Gutell Robin R, McCook Amanda S, Richardson Paul E, Caulfield Thomas R, Agrawal Rajendra K, Harvey Stephen C", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS0", "url": "https://www.uniprot.org/uniprotkb/Q3SYS0" } ], "reference": [ { "type": "PubMed", "id": "16510155", "url": "https://glygen.org/publication/PubMed/16510155" } ] } ], "pathway": [ { "id": "bta:532203", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532203", "resource": "KEGG Pathway" }, { "id": "R-BTA-5389840", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-9937383", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "resource": "Reactome", "description": "Mitochondrial ribosome-associated quality control" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RHJ1-1", "protein_name": "Large ribosomal subunit protein uL24m", "gene_name": "MRPL24", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRLSALLALASKVTLPPNYRYGMSRPGSLSDKRKNPPGTRRRRVPVEPISDEDWHLFCGDKVEILEGKDAGKQGKVVQVIRQRNWVVVEGLNTHYRYVGKTVDYRGTMIPSEAPLLHNQVKLVDPTDRKPTDVEWRFTEAGERVRVSTRSGRIIPKPEFPRADGIVPETWIDGPKDTSVEDALEKTYVPRLKTLEEEVMEAMGIQETRRHKKVYWY", "length": 216 }, "evidence": [ { "id": "Q3SYS0", "url": "https://omabrowser.org/oma/group/Q3SYS0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HG71-1", "protein_name": "Large ribosomal subunit protein uL24m", "gene_name": "Mrpl24", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRLSALLALASKATLPPHYRYGMSRPGSLSDKRKNPPWSRRRPVVVEPISDEDWHLFCGDMVEILEGKDAGKQGKVVQVIRQRNWVVLEGLNTHFRYIGRTKDHRGTMIPSEAPLLHHQVKLVDPVDRKPTEVQWRFTESGERVRVSTRSGRIIPKPEFPRADGIVPEIWTDGPKDTSVEDALKKTYVPRLKTLEEDVMEAMGIQEPRKHKKVYWY", "length": 216 }, "evidence": [ { "id": "Q3SYS0", "url": "https://omabrowser.org/oma/group/Q3SYS0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q55DJ4-1", "protein_name": "KOW domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSLFGGRTFKEGIFLIPKWKYVKGDKVQIISGKDKGKQGIIKSVNKKDSNLIVEGLKLLKKLTKPNKRSKAMAYTKEAPIHYSNISHIDPKYNVPCKVRFQLVDGARERVSKISNSIIAKPDLSANFKKWRRDNVEGPYDTTPEIVKKRTFDGIIENIHPHKTY", "length": 164 }, "evidence": [ { "id": "Q3SYS0", "url": "https://omabrowser.org/oma/group/Q3SYS0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q66H47-1", "protein_name": "Large ribosomal subunit protein uL24m", "gene_name": "Mrpl24", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRLSALLALASKATLSPHYRYGMSRPGSIADKRKNPPWSRRRPVVVEPISDEDWHLFCGDMVEILEGKDAGKQGKVVQVVRQRNWVVLEGLNTHYRYIGRTKDHRGTMIPSEAPLLHHQVKLVDPVDRKPTEIQWRFTEAGERVRVSTRSGRIIPKPEFPRADGIVPETWTDGPKDTSVEDALERTYVPRLKTLEEDVMEAMGIQETRRFKKIYWY", "length": 216 }, "evidence": [ { "id": "Q3SYS0", "url": "https://omabrowser.org/oma/group/Q3SYS0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6DH02-1", "protein_name": "Large ribosomal subunit protein uL24m", "gene_name": "mrpl24", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRLTALLSMAAKVALPHGYRYGTNRPWTIAARRLNPPGKRRRKVFVEPIANEDWPVVRGDTVEVLSGKEKGKQGKVAQVIRARNWVILEGLNTHYRYVGRSGDYRGTYLASEAPLLLKDIALIDPTDRKPTEIQWRYTEEGERVRVSVRTGRIIPKPVFQRKDGIVPQQWKDGPKDTSPEDTLQKTYTPSLKTLEEEVMEKMNIQENRRPRKSYWY", "length": 216 }, "evidence": [ { "id": "Q3SYS0", "url": "https://omabrowser.org/oma/group/Q3SYS0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q96A35-1", "protein_name": "Large ribosomal subunit protein uL24m", "gene_name": "MRPL24", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRLSALLALASKVTLPPHYRYGMSPPGSVADKRKNPPWIRRRPVVVEPISDEDWYLFCGDTVEILEGKDAGKQGKVVQVIRQRNWVVVGGLNTHYRYIGKTMDYRGTMIPSEAPLLHRQVKLVDPMDRKPTEIEWRFTEAGERVRVSTRSGRIIPKPEFPRADGIVPETWIDGPKDTSVEDALERTYVPCLKTLQEEVMEAMGIKETRKYKKVYWY", "length": 216 }, "evidence": [ { "id": "Q3SYS0", "url": "https://omabrowser.org/oma/group/Q3SYS0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CQ06-1", "protein_name": "Large ribosomal subunit protein uL24m", "gene_name": "Mrpl24", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRLSALLALASKATSSPFYRYGMSRPGSIADKRKNPPWSRRRPVVVEPISDEDWHLFCGDMVEILEGKDAGKQGKVVQVVRQRNWVVLEGLNTHYRYIGRTKDHRGTMIASEAPLLHHQVKLVDPVDRKPTEIQWRFTEAGERVRVSTRSGRIIPKPEFPRADGIVPETWTDGPKDTSVEDALERTYVPRLKTLEEDVMEAMGIQETRRFKKVYWY", "length": 216 }, "evidence": [ { "id": "Q3SYS0", "url": "https://omabrowser.org/oma/group/Q3SYS0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VMY1-1", "protein_name": "Large ribosomal subunit protein uL24m", "gene_name": "mRpL24", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MRLTQYLASKLKNFSNLPKEYIERSKKQVYWQTPKEINYLPRTVERKRFRYTTNRSWTGQFRQQNMPGTVRRKVLVEPIEDWSFFRGDRIEVLVGKDKGKQGIVTQVIPERNWVIVEGLNWHYRKVGGEKEFPGIIIKSEAPLHVTKDIRLVDPSDLQGTDFEWRFTEEGEKVRVSLRSGRIIPIPETNNQTHDYKTPNAYIEREKDTPGAVVGEITFQPKLSTFEMDIMEEMGIKEERTPVKSYWY", "length": 247 }, "evidence": [ { "id": "Q3SYS0", "url": "https://omabrowser.org/oma/group/Q3SYS0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS0", "url": "https://www.uniprot.org/uniprotkb/Q3SYS0" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS0", "url": "https://www.uniprot.org/uniprotkb/Q3SYS0" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS0", "url": "https://www.uniprot.org/uniprotkb/Q3SYS0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS0", "url": "https://www.uniprot.org/uniprotkb/Q3SYS0" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS0", "url": "https://www.uniprot.org/uniprotkb/Q3SYS0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS0", "url": "https://www.uniprot.org/uniprotkb/Q3SYS0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SYS0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 216, 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"table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3SYS4-1", "uniprot_ac": "Q3SYS4", "uniprot_id": "DAAF1_BOVIN", "mass": { "chemical_mass": 71786.0, "monoisotopic_mass": 71786.0 }, "refseq": { "ac": "NP_001030422", "name": "dynein axonemal assembly factor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030422" }, "gene_names": [ { "name": "DNAAF1", "type": "recommended", "evidence": [ { "id": "Q3SYS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYS4" } ] }, { "name": "DNAAF1", "type": "synonym", "evidence": [ { "id": "NP_001030422", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030422" } ] }, { "name": "LLRC50", "type": "synonym", "evidence": [ { "id": "NP_001030422", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030422" } ] }, { "name": "LRRC50", "type": "synonym", "evidence": [ { "id": 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Plays a role in cytoplasmic preassembly of dynein arms (By similarity). Involved in regulation of microtubule-based cilia and actin-based brush border microvilli (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS4", "url": "https://www.uniprot.org/uniprotkb/Q3SYS4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SYS4", "url": "https://www.uniprot.org/uniprotkb/Q3SYS4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAAF1", "url": "https://www.uniprot.org/uniprotkb/Q3SYS4", "locus": { "chromosome": "18", "start_pos": 10469494, "end_pos": 10448568, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018771", "url": "https://www.ensembl.org/id/ENSBTAG00000018771" } ] } } ], "crossref": [ { "id": "Q3SYS4", "url": "https://alphafold.ebi.ac.uk/entry/Q3SYS4", "database": "AlphaFoldDB", "categories": [] }, { "id": "523187", "url": "https://www.ncbi.nlm.nih.gov/gene/523187", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050576", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050576", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523187", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523187", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SYS4", "url": "https://www.orthodb.org/?gene=Q3SYS4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45973", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45973", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45973:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45973:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14580", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14580", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030422", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SYS4", "url": "https://www.uniprot.org/uniprotkb/Q3SYS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYS4-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYS4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHPEASEPVVDGVAEQECAQEPGVEESAGDHGNAGEGGRKEEMNDPKETCVGPLNTSCLSEQKQSGDSWSDGRLAHQRADKEDRGARMTKKFLQKLCKQHKLYITPALNDTLYLHYKGFDRIENLEEYTGLRCLWLECNGIQKIENLEAQTELRCLFLQVNLLHKIENLEPLQKLDALNISNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLRECARLCVLDLSHNKLSDPEILRVLESMPDLRVLNLMGNPVIKNIPNYRRILTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAEKEERQQREMRERKKITDSIEALAALRRQAEERKWQRASQEQGEEPTPAGAGDVDAEVEGEEEPQEKDTRQKIEQFVKESFEAKDELFPEKPEEPSLLEELPLDVGEPKGVLPSEVLPASPRAAWAELAPQTVATESASGTEPDGAENLEATRLETKEQLFIDDLPNLEDVNAGESLGDRDREQCFPKITAISSLSDASEPDMDDISLLALENTSSDTLSSIFAVPKDTSWRVETETPFTDILKVAPERDPETQRKASEVPRPLIQELGDDEEPSGPPPLPPVCEGEAVPAPCTEDSDGDLLPAPAPGNGPEKDEVQSEVEPEERLGSEAGENREDIEFGLD", "length": 643, "header": "sp|Q3SYS4-1|DAAF1_BOVIN Isoform 1 of Dynein axonemal assembly factor 1 OS=Bos taurus OX=9913 GN=DNAAF1 PE=2 SV=2 CANONICAL=Q3SYS4-1" }, "isoforms": [ { "isoform_ac": "Q3SYS4-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYS4/entry#Q3SYS4-1", "sequence": { "sequence": "MHPEASEPVVDGVAEQECAQEPGVEESAGDHGNAGEGGRKEEMNDPKETCVGPLNTSCLSEQKQSGDSWSDGRLAHQRADKEDRGARMTKKFLQKLCKQHKLYITPALNDTLYLHYKGFDRIENLEEYTGLRCLWLECNGIQKIENLEAQTELRCLFLQVNLLHKIENLEPLQKLDALNISNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLRECARLCVLDLSHNKLSDPEILRVLESMPDLRVLNLMGNPVIKNIPNYRRILTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAEKEERQQREMRERKKITDSIEALAALRRQAEERKWQRASQEQGEEPTPAGAGDVDAEVEGEEEPQEKDTRQKIEQFVKESFEAKDELFPEKPEEPSLLEELPLDVGEPKGVLPSEVLPASPRAAWAELAPQTVATESASGTEPDGAENLEATRLETKEQLFIDDLPNLEDVNAGESLGDRDREQCFPKITAISSLSDASEPDMDDISLLALENTSSDTLSSIFAVPKDTSWRVETETPFTDILKVAPERDPETQRKASEVPRPLIQELGDDEEPSGPPPLPPVCEGEAVPAPCTEDSDGDLLPAPAPGNGPEKDEVQSEVEPEERLGSEAGENREDIEFGLD", "length": 643, "header": "sp|Q3SYS4-1|DAAF1_BOVIN Isoform 1 of Dynein axonemal assembly factor 1 OS=Bos taurus OX=9913 GN=DNAAF1 PE=2 SV=2 CANONICAL=Q3SYS4-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 348, "start_aa": "Thr", "end_pos": 348, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr348", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 477, "end_pos": 477, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS4", "url": "https://www.uniprot.org/uniprotkb/Q3SYS4" } ], "site_lbl": "Ser477" }, { "start_pos": 500, "end_pos": 500, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS4", "url": "https://www.uniprot.org/uniprotkb/Q3SYS4" } ], "site_lbl": "Ser500" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:523187", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523187", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS4", "url": "https://www.uniprot.org/uniprotkb/Q3SYS4" } ], "pmid": "" }, { "name": "determination of left/right symmetry", "id": "GO:0007368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007368", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS4", "url": "https://www.uniprot.org/uniprotkb/Q3SYS4" } ], "pmid": "" }, { "name": "axoneme assembly", "id": "GO:0035082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035082", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS4", "url": "https://www.uniprot.org/uniprotkb/Q3SYS4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS4", "url": "https://www.uniprot.org/uniprotkb/Q3SYS4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "dynein complex binding", "id": "GO:0070840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070840", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS4", "url": "https://www.uniprot.org/uniprotkb/Q3SYS4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 514, "end_pos": 516, "annotation": "n_glycosylation_sequon" }, { "start_pos": 55, "end_pos": 57, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SYS4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 643, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SYS4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SYS4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 348 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 477, 500 ], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 111 }, { "start_pos": 179, "end_pos": 181 }, { "start_pos": 190, "end_pos": 192 }, { "start_pos": 514, "end_pos": 516 }, { "start_pos": 55, "end_pos": 57 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SYS8-1", "uniprot_ac": "Q3SYS8", "uniprot_id": "I22R1_BOVIN", "mass": { "chemical_mass": 63776.0, "monoisotopic_mass": 63776.0 }, "refseq": { "ac": "NP_001029483", "name": "interleukin-22 receptor subunit alpha-1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029483" }, "gene_names": [ { "name": "IL22RA1", "type": "recommended", "evidence": [ { "id": "Q3SYS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYS8" } ] }, { "name": "IL22RA1", "type": "synonym", "evidence": [ { "id": "NP_001029483", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029483" } ] } ], "protein_names": [ { "name": "Interleukin-22 receptor subunit alpha-1", "type": "recommended", "evidence": [ { "id": "Q3SYS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYS8/entry#names_and_taxonomy" } ] }, { "name": "IL-22 receptor subunit alpha-1", "type": "synonym", "evidence": [ { "id": "NP_001029483", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029483" }, { "id": "Q3SYS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYS8/entry#names_and_taxonomy" } ] }, { "name": "IL-22R-alpha-1", "type": "synonym", "evidence": [ { "id": "NP_001029483", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029483" }, { "id": "Q3SYS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYS8/entry#names_and_taxonomy" } ] }, { "name": "IL-22RA1", "type": "synonym", "evidence": [ { "id": "NP_001029483", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029483" }, { "id": "Q3SYS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYS8/entry#names_and_taxonomy" } ] }, { "name": "interleukin 22 receptor, alpha 1", "type": "synonym", "evidence": [ { "id": "NP_001029483", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029483" } ] }, { "name": "interleukin-22 receptor subunit alpha-1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001029483", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029483" } ] } ], "function": [ { "annotation": "Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS8", "url": "https://www.uniprot.org/uniprotkb/Q3SYS8#function" }, { "database": "UniProtKB", "id": "Q8N6P7", "url": "https://www.uniprot.org/uniprotkb/Q8N6P7#function" } ] }, { "annotation": "SNPs in IFNG, IFNGR1 and R2, IL22, and IL22RA1 were analyzed for an association to Estimated breeding values for somatic cell score in Canadian Holstein bulls; no significant associations were found.", "evidence": [ { "database": "RefSeq", "id": "NP_001029483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029483" }, { "database": "PubMed", "id": "21328101", "url": "https://glygen.org/publication/PubMed/21328101" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SYS8", "url": "https://www.uniprot.org/uniprotkb/Q3SYS8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL22RA1", "url": "https://www.uniprot.org/uniprotkb/Q3SYS8", "locus": { "chromosome": "2", "start_pos": 128780184, "end_pos": 128753566, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001100", "url": "https://www.ensembl.org/id/ENSBTAG00000001100" } ] } } ], "crossref": [ { "id": "Q3SYS8", "url": "https://alphafold.ebi.ac.uk/entry/Q3SYS8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508044", "url": "https://www.ncbi.nlm.nih.gov/gene/508044", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015373", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015373", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508044", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508044", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SYS8", "url": "https://www.orthodb.org/?gene=Q3SYS8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20859", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20859", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20859:SF53", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20859:SF53", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01108", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01108", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09294", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09294", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029483", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SYS8", "url": "https://www.uniprot.org/uniprotkb/Q3SYS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYS8-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYS8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRTLLTILAAGSLLAHITEDTSDLLQHVKFQSSNFENILTWDGRPESPPDTVYSVQYKTYGEEEWLEKEGCQRITQKSCNLTMETSNLTELYYARVTATDGAGRSATKMTNRFSSLQHTSIKPPDVTCIPKVRSIQMIVHPTYTPIRAQNGHQLTLENIFQDLLYHLKLRINHTYQMHLEGKQREFEFVGLTPDTEFLGTIMICIPNLFKESTPYMCRVKTLPDRTWTYSFSGAFLFSLGFLVAGLCYLSYRYITKPPPPPSSLNVQHILPFRPLQFIQEHTLIPVFDLSGSGGLAQPVQYSEVKVSNPTEPPGPPPRHSLPEIAYLGQPDLPVLRPSGGPPHQALPVLSYAPQAAPEGRPSSYAPQGALEAKPPSYTPQAVSETQLPSYTPRATPDNWPPSYGMCGEGSGRDSPPVTRSGPKHLGTKGQLQKEVPAGSCSPTGLSLQEVTPLAMEDPQEAKSSHQCLRVHTDSDSDSDTIGQREPGTRSSLKGQLPLLSSVQIEGHPGCLPLQTPSLPCSPTDKGPSPWGLLESLVCPSDEDPVSKTEAESPGLQAPDLESPTELDSLFRGLALTVQWES", "length": 581, "header": "sp|Q3SYS8-1|I22R1_BOVIN Isoform 1 of Interleukin-22 receptor subunit alpha-1 OS=Bos taurus OX=9913 GN=IL22RA1 PE=2 SV=1 CANONICAL=Q3SYS8-1" }, "isoforms": [ { "isoform_ac": "Q3SYS8-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYS8/entry#Q3SYS8-1", "sequence": { "sequence": "MRTLLTILAAGSLLAHITEDTSDLLQHVKFQSSNFENILTWDGRPESPPDTVYSVQYKTYGEEEWLEKEGCQRITQKSCNLTMETSNLTELYYARVTATDGAGRSATKMTNRFSSLQHTSIKPPDVTCIPKVRSIQMIVHPTYTPIRAQNGHQLTLENIFQDLLYHLKLRINHTYQMHLEGKQREFEFVGLTPDTEFLGTIMICIPNLFKESTPYMCRVKTLPDRTWTYSFSGAFLFSLGFLVAGLCYLSYRYITKPPPPPSSLNVQHILPFRPLQFIQEHTLIPVFDLSGSGGLAQPVQYSEVKVSNPTEPPGPPPRHSLPEIAYLGQPDLPVLRPSGGPPHQALPVLSYAPQAAPEGRPSSYAPQGALEAKPPSYTPQAVSETQLPSYTPRATPDNWPPSYGMCGEGSGRDSPPVTRSGPKHLGTKGQLQKEVPAGSCSPTGLSLQEVTPLAMEDPQEAKSSHQCLRVHTDSDSDSDTIGQREPGTRSSLKGQLPLLSSVQIEGHPGCLPLQTPSLPCSPTDKGPSPWGLLESLVCPSDEDPVSKTEAESPGLQAPDLESPTELDSLFRGLALTVQWES", "length": 581, "header": "sp|Q3SYS8-1|I22R1_BOVIN Isoform 1 of Interleukin-22 receptor subunit alpha-1 OS=Bos taurus OX=9913 GN=IL22RA1 PE=2 SV=1 CANONICAL=Q3SYS8-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 80, "start_aa": "Asn", "end_pos": 80, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn80", "evidence": [ { "id": "Q3SYS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYS8#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 410, "end_pos": 410, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS8", "url": "https://www.uniprot.org/uniprotkb/Q3SYS8" } ], "site_lbl": "Ser410" }, { "start_pos": 414, "end_pos": 414, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS8", "url": "https://www.uniprot.org/uniprotkb/Q3SYS8" } ], "site_lbl": "Ser414" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Identification of SNPs in interferon gamma, interleukin-22, and their receptors and associations with health and production-related traits in Canadian Holstein bulls.", "journal": "Animal biotechnology", "date": "2011-01", "authors": "Verschoor Chris P, Pant Sameer D, Biggar Graham A, Schenkel Flavio S, Sharma Bhawani S, Karrow Niel A", "evidence": [ { "database": "RefSeq", "id": "NP_001029483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029483" } ], "reference": [ { "type": "PubMed", "id": "21328101", "url": "https://glygen.org/publication/PubMed/21328101" } ] } ], "pathway": [ { "id": "bta:508044", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508044", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS8", "url": "https://www.uniprot.org/uniprotkb/Q3SYS8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cytokine-mediated signaling pathway", "id": "GO:0019221", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019221", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS8", "url": "https://www.uniprot.org/uniprotkb/Q3SYS8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cytokine receptor activity", "id": "GO:0004896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004896", "evidence": [ { "database": "UniProtKB", "id": "Q3SYS8", "url": "https://www.uniprot.org/uniprotkb/Q3SYS8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 172, "end_pos": 174, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SYS8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 581, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SYS8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SYS8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 80 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 410, 414 ], "sequon_annotation_sites": [ { "start_pos": 172, "end_pos": 174 }, { "start_pos": 80, "end_pos": 82 }, { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3SYU3-1", "uniprot_ac": "Q3SYU3", "uniprot_id": "S39A1_BOVIN", "mass": { "chemical_mass": 34205.0, "monoisotopic_mass": 34205.0 }, "refseq": { "ac": "NP_001030458", "name": "zinc transporter ZIP1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030458" }, "gene_names": [ { "name": "SLC39A1", "type": "recommended", "evidence": [ { "id": "Q3SYU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU3" } ] }, { "name": "SLC39A1", "type": "synonym", "evidence": [ { "id": "NP_001030458", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030458" } ] }, { "name": "ZIP1", "type": "synonym", "evidence": [ { "id": "Q3SYU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU3" } ] } ], "protein_names": [ { "name": "Zinc transporter ZIP1", "type": "recommended", "evidence": [ { "id": "Q3SYU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU3/entry#names_and_taxonomy" } ] }, { "name": "Solute carrier family 39 member 1", "type": "synonym", "evidence": [ { "id": "Q3SYU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU3/entry#names_and_taxonomy" } ] }, { "name": "ZIP-1", "type": "synonym", "evidence": [ { "id": "NP_001030458", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030458" }, { "id": "Q3SYU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU3/entry#names_and_taxonomy" } ] }, { "name": "Zrt- and Irt-like protein 1", "type": "synonym", "evidence": [ { "id": "Q3SYU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU3/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 39 (zinc transporter), member 1", "type": "synonym", "evidence": [ { "id": "NP_001030458", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030458" } ] }, { "name": "zinc transporter ZIP1", "type": "synonym", "evidence": [ { "id": "NP_001030458", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030458" } ] }, { "name": "zrt- and Irt-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001030458", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030458" } ] } ], "function": [ { "annotation": "Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space.", "evidence": [ { "database": "UniProtKB", "id": "Q3SYU3", "url": "https://www.uniprot.org/uniprotkb/Q3SYU3#function" }, { "database": "UniProtKB", "id": "Q9NY26", "url": "https://www.uniprot.org/uniprotkb/Q9NY26#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SYU3", "url": "https://www.uniprot.org/uniprotkb/Q3SYU3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC39A1", "url": "https://www.uniprot.org/uniprotkb/Q3SYU3", "locus": { "chromosome": "3", "start_pos": 16477147, "end_pos": 16473115, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011284", "url": "https://www.ensembl.org/id/ENSBTAG00000011284" } ] } } ], "crossref": [ { "id": "Q3SYU3", "url": "https://alphafold.ebi.ac.uk/entry/Q3SYU3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011284", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011284", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "530352", "url": "https://www.ncbi.nlm.nih.gov/gene/530352", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003689", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003689", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530352", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530352", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HEMSHTH", "url": "https://omabrowser.org/oma/group/HEMSHTH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SYU3", "url": "https://www.orthodb.org/?gene=Q3SYU3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11040", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11040", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11040:SF58", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11040:SF58", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02535", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02535", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-442380", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-442380", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030458", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29351", "url": "https://www.rhea-db.org/rhea/29351", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SYU3", "url": "https://www.uniprot.org/uniprotkb/Q3SYU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYU3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYU3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGPWGEPELLVWRPEAAASEAPVPMGLEVKLGALVLLLVLTLICSLVPVCVLRRPGANPEASASRQKALSLVSCFAGGVFLATCLLDLLPDYLGAIDEALAALHVTLQFPLQEFILAMGFFLVLVMEQITLAYKEQSGPPPREETRALLGTVNGGPQHWHDGLGVPQAGGASSAPSALRACVLVFSLALHSVFEGLAVGLQRDQARAMELCLALLLHKGILAVSLSLRLLQSHLRAQVVAGCGILFSCMTPLGIGLGTALAESAGPLHQLAQSVLEGMAAGTFLYITFLEILPQELATSEQRILKVILLLAGFALLTGLLFIQI", "length": 324, "header": "sp|Q3SYU3-1|S39A1_BOVIN Isoform 1 of Zinc transporter ZIP1 OS=Bos taurus OX=9913 GN=SLC39A1 PE=2 SV=1 CANONICAL=Q3SYU3-1" }, "isoforms": [ { "isoform_ac": "Q3SYU3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYU3/entry#Q3SYU3-1", "sequence": { "sequence": "MGPWGEPELLVWRPEAAASEAPVPMGLEVKLGALVLLLVLTLICSLVPVCVLRRPGANPEASASRQKALSLVSCFAGGVFLATCLLDLLPDYLGAIDEALAALHVTLQFPLQEFILAMGFFLVLVMEQITLAYKEQSGPPPREETRALLGTVNGGPQHWHDGLGVPQAGGASSAPSALRACVLVFSLALHSVFEGLAVGLQRDQARAMELCLALLLHKGILAVSLSLRLLQSHLRAQVVAGCGILFSCMTPLGIGLGTALAESAGPLHQLAQSVLEGMAAGTFLYITFLEILPQELATSEQRILKVILLLAGFALLTGLLFIQI", "length": 324, "header": "sp|Q3SYU3-1|S39A1_BOVIN Isoform 1 of Zinc transporter ZIP1 OS=Bos taurus OX=9913 GN=SLC39A1 PE=2 SV=1 CANONICAL=Q3SYU3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:530352", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530352", "resource": "KEGG Pathway" }, { "id": "R-BTA-442380", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-442380", "resource": "Reactome", "description": "Zinc influx into cells by the SLC39 gene family" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RFX1-1", "protein_name": "Solute carrier family 39 member 1", "gene_name": "SLC39A1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGPWGEPELLVWRPEAAASEPPVPVGLEVKLGALVLLLVLTLICSLVPICVLRRTGANPEASASRQKALSLVSCFAGGVFLATCLLDLLPDYLAAIDEALAALHVTLQFPLQEFILAMGFFLVLVMEQITLAYKEQSGPPPREEMRALLGTTNGGPQHWHDGSGVPQAGGALAAPSALRACVLVFSLALHSVFEGLAVGLQRDRARAMELCLALLLHKGILAVSLSLRLLQSHLRAQVVAGCGILFSCMTPLGIGLGAALAESAGPLHQLAQSVLEGMAAGTFLYITFLEILPQELATSEQRILKVILLLAGFALLTGLLFIQV", "length": 324 }, "evidence": [ { "id": "Q3SYU3", "url": "https://omabrowser.org/oma/group/Q3SYU3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HC09-1", "protein_name": "Zinc transporter ZIP1 isoform X1", "gene_name": "Slc39a1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGPWGEPELLVWRPEAIASEPSVPVGLEVKLGALVLLLLLTLVCSLVPVCVLRRPGASHEASASGQKILSLVSCFAGGVFLATCLLDLLPDYLAAIDEALAALHVTLQFPLQEFILAMGFFLVLVMEQITLAYKEQSSPPHPEETRALLGSVNGGPQHWHDGPGIPQASGTPAAPSALRACVLVFSLALHSVFEGLAVGLQRDRARAMELCLALLFHKGILAVSLSLRLLQSHLRVQVVAGCGILFSCMTPLGIGLGTALSESAGPLHQLAQSVLEGMAAGTFLYITFLEILPQELATSEQRILKVILLLAGFALLTGLLFIEI", "length": 324 }, "evidence": [ { "id": "Q3SYU3", "url": "https://omabrowser.org/oma/group/Q3SYU3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q94EG9-1", "protein_name": "Zinc transporter 11", "gene_name": "ZIP11", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSRSLVFFFLFLVLVVPCLSHGTGGDHDDDEASHVKSSDLKSKSLISVKIACLVIIFVLTFISGVSPYFLKWSQGFLVLGTQFAGGVFLATALMHFLSDADETFRGLLTAEGESEPSPAYPFAYMLACAGFMLTMLADSVIAHIYSKTQNDLELQGEDKSNQRSATTETSIGDSILLIVALCFHSVFEGIAIGISETKSDAWRALWTITLHKIFAAIAMGIALLRMIPDRPLFSSITYSFAFAISSPIGVAIGIVIDATTQGSIADWIFALSMSLACGVFVYVSVNHLLAKGYRPNKKVHVDEPRYKFLAVLFGVVVIAIVMIWDT", "length": 326 }, "evidence": [ { "id": "Q3SYU3", "url": "https://omabrowser.org/oma/group/Q3SYU3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9NY26-1", "protein_name": "Zinc transporter ZIP1", "gene_name": "SLC39A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGPWGEPELLVWRPEAVASEPPVPVGLEVKLGALVLLLVLTLLCSLVPICVLRRPGANHEGSASRQKALSLVSCFAGGVFLATCLLDLLPDYLAAIDEALAALHVTLQFPLQEFILAMGFFLVLVMEQITLAYKEQSGPSPLEETRALLGTVNGGPQHWHDGPGVPQASGAPATPSALRACVLVFSLALHSVFEGLAVGLQRDRARAMELCLALLLHKGILAVSLSLRLLQSHLRAQVVAGCGILFSCMTPLGIGLGAALAESAGPLHQLAQSVLEGMAAGTFLYITFLEILPQELASSEQRILKVILLLAGFALLTGLLFIQI", "length": 324 }, "evidence": [ { "id": "Q3SYU3", "url": "https://omabrowser.org/oma/group/Q3SYU3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QZ03-1", "protein_name": "Zinc transporter ZIP1", "gene_name": "Slc39a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGPWGEPELLVWRPEAVASEPSVPVGLEVKLGALVLLLLLTLICSLVPVCVLRRSGANHEASASGQKALSLVSCFAGGVFLATCLLDLLPDYLAAIDEALEALHVTLQFPLQEFILAMGFFLVLVMEQITLAYKEQTSPPHPEETRALLGTVNGGPQHWHDGPGIPQAGGTPAAPSALRACVLVFSLALHSVFEGLAVGLQRDRARAMELCLALLLHKGILAVSLSLRLLQSHLRVQVVAGCGILFSCMTPLGIGLGAALAESAGPLHQLAQSVLEGMAAGTFLYITFLEILPQELATSEQRILKVILLLAGFALLTGLLFVQI", "length": 324 }, "evidence": [ { "id": "Q3SYU3", "url": "https://omabrowser.org/oma/group/Q3SYU3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion transmembrane transporter activity", "id": "GO:0005385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005385", "evidence": [ { "database": "UniProtKB", "id": "Q3SYU3", "url": "https://www.uniprot.org/uniprotkb/Q3SYU3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "zinc ion transmembrane transport", "id": "GO:0071577", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071577", "evidence": [ { "database": "UniProtKB", "id": "Q3SYU3", "url": "https://www.uniprot.org/uniprotkb/Q3SYU3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3SYU3", "url": "https://www.uniprot.org/uniprotkb/Q3SYU3" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3SYU3", "url": "https://www.uniprot.org/uniprotkb/Q3SYU3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29351", "name": "", "equation": "Zn(2+)(in) = Zn(2+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MPF0-1", "A0AAA9RSQ6-1" ], "evidence": [ { "id": "29351", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29351" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SYU3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 324, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SYU3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SYU3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SYU9-1", "uniprot_ac": "Q3SYU9", "uniprot_id": "MVP_BOVIN", "mass": { "chemical_mass": 98924.0, "monoisotopic_mass": 98924.0 }, "refseq": { "ac": "NP_001030394", "name": "major vault protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030394" }, "gene_names": [ { "name": "MVP", "type": "recommended", "evidence": [ { "id": "Q3SYU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU9" } ] }, { "name": "MVP", "type": "synonym", "evidence": [ { "id": "NP_001030394", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030394" } ] } ], "protein_names": [ { "name": "Major vault protein", "type": "recommended", "evidence": [ { "id": "Q3SYU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU9/entry#names_and_taxonomy" } ] }, { "name": "MVP", "type": "synonym", "evidence": [ { "id": "Q3SYU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU9/entry#names_and_taxonomy" } ] }, { "name": "major vault protein", "type": "synonym", "evidence": [ { "id": "NP_001030394", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030394" } ] } ], "function": [ { "annotation": "Structural component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction (By similarity). Oligomerizes to form a cage-like vault complex, which can house several minor vault components including PARP4 (By similarity). Vaults may play a role in nucleo-cytoplasmic transport (By similarity). Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK (By similarity). Down-regulates SRC activity and signaling through MAP kinases (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SYU9", "url": "https://www.uniprot.org/uniprotkb/Q3SYU9#function" }, { "database": "UniProtKB", "id": "Q14764", "url": "https://www.uniprot.org/uniprotkb/Q14764#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SYU9", "url": "https://www.uniprot.org/uniprotkb/Q3SYU9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MVP", "url": "https://www.uniprot.org/uniprotkb/Q3SYU9", "locus": { "chromosome": "25", "start_pos": 26403797, "end_pos": 26423620, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007952", "url": "https://www.ensembl.org/id/ENSBTAG00000007952" } ] } } ], "crossref": [ { "id": "Q3SYU9", "url": "https://alphafold.ebi.ac.uk/entry/Q3SYU9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd08825", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08825", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "516456", "url": "https://www.ncbi.nlm.nih.gov/gene/516456", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036013", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036013", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039059", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039059", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041134", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041134", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041139", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041139", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043023", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043023", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516456", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516456", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SYU9", "url": "https://www.orthodb.org/?gene=Q3SYU9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14165", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14165", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14165:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14165:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01505", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01505", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11978", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11978", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17794", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17794", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17795", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17795", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030394", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SYU9", "url": "https://www.uniprot.org/uniprotkb/Q3SYU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYU9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYU9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSMEESIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERILFAPVRMLTVPPRHYCMVANPVARDAQGTVLFDVTGQVRLRHADLEIRLAQDPFPLFPGEVLEKDITPLQVVLPNTALHLKALLDFEDKNGQKVVAGDEWLFEGPGTYIPQKEVEVIEIIQATVIKQNQALRLRARKECLDRDGKERVTGEEWLVRSVGAYLPAVFEEVLDVVDAVILTEKTALHLRARQNFRDVRGVTRRTGEEWLVTVQDTEAHVPDVYEEVMGVVSVTTLGPHNYCVILDPVGPDGKNQLGQKLVFKGEQSFFLQPGEKLERGIQNVYVLSEQQGLLLRALQPLEEGEGKEKVSHQAGDHWLIRGPLEYVPPAKVEVVEERQAIPLDENEGIYVQDVKTGRVRAVIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGEKETSKTPKLSTPRNKTRVVSYRVPHNAAVQVYDYREKKARVVFGPELVLLGPEEQFTVLSLSAGRPKRPHARRTLCLLLGPDFFTDVITIETADHARLQLQLAYNWHFELSDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGFETQETKGPDTMALPQPRDRAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEIATNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARRELLELEALSTAVESTGTAKAEAESRAEAARIEGEGAVLQAKLKAEALAIETEAELERVKKVRELELLYARAQLELEVSKAQQLAEVEVKKFKQMTEALGPSTIRDMAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTALGLLGLGAEAQPPAKKPTGGPSVQEGLLPISTAAPLTLGNNQVVP", "length": 890, "header": "sp|Q3SYU9-1|MVP_BOVIN Isoform 1 of Major vault protein OS=Bos taurus OX=9913 GN=MVP PE=2 SV=1 CANONICAL=Q3SYU9-1" }, "isoforms": [ { "isoform_ac": "Q3SYU9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYU9/entry#Q3SYU9-1", "sequence": { "sequence": "MSMEESIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERILFAPVRMLTVPPRHYCMVANPVARDAQGTVLFDVTGQVRLRHADLEIRLAQDPFPLFPGEVLEKDITPLQVVLPNTALHLKALLDFEDKNGQKVVAGDEWLFEGPGTYIPQKEVEVIEIIQATVIKQNQALRLRARKECLDRDGKERVTGEEWLVRSVGAYLPAVFEEVLDVVDAVILTEKTALHLRARQNFRDVRGVTRRTGEEWLVTVQDTEAHVPDVYEEVMGVVSVTTLGPHNYCVILDPVGPDGKNQLGQKLVFKGEQSFFLQPGEKLERGIQNVYVLSEQQGLLLRALQPLEEGEGKEKVSHQAGDHWLIRGPLEYVPPAKVEVVEERQAIPLDENEGIYVQDVKTGRVRAVIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGEKETSKTPKLSTPRNKTRVVSYRVPHNAAVQVYDYREKKARVVFGPELVLLGPEEQFTVLSLSAGRPKRPHARRTLCLLLGPDFFTDVITIETADHARLQLQLAYNWHFELSDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGFETQETKGPDTMALPQPRDRAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEIATNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARRELLELEALSTAVESTGTAKAEAESRAEAARIEGEGAVLQAKLKAEALAIETEAELERVKKVRELELLYARAQLELEVSKAQQLAEVEVKKFKQMTEALGPSTIRDMAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTALGLLGLGAEAQPPAKKPTGGPSVQEGLLPISTAAPLTLGNNQVVP", "length": 890, "header": "sp|Q3SYU9-1|MVP_BOVIN Isoform 1 of Major vault protein OS=Bos taurus OX=9913 GN=MVP PE=2 SV=1 CANONICAL=Q3SYU9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:516456", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516456", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3SYU9", "url": "https://www.uniprot.org/uniprotkb/Q3SYU9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SYU9", "url": "https://www.uniprot.org/uniprotkb/Q3SYU9" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q3SYU9", "url": "https://www.uniprot.org/uniprotkb/Q3SYU9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" }, { "start_pos": 453, "end_pos": 455, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SYU9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 890, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SYU9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SYU9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SYU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU9" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MVP shoulder", "eco_id": "ECO_0000250", "start_pos": 519, "end_pos": 646, "start_aa": "Gly", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 24, "end_pos": 26 }, { "start_pos": 453, "end_pos": 455 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SYV3-1", "uniprot_ac": "Q3SYV3", "uniprot_id": "OXA1L_BOVIN", "mass": { "chemical_mass": 48987.0, "monoisotopic_mass": 48987.0 }, "refseq": { "ac": "NP_001030412", "name": "mitochondrial inner membrane protein OXA1L", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030412" }, "gene_names": [ { "name": "OXA1L", "type": "recommended", "evidence": [ { "id": "Q3SYV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3" } ] }, { "name": "OXA1L", "type": "synonym", "evidence": [ { "id": "NP_001030412", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030412" } ] } ], "protein_names": [ { "name": "Mitochondrial inner membrane protein OXA1L", "type": "recommended", "evidence": [ { "id": "Q3SYV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3/entry#names_and_taxonomy" } ] }, { "name": "OXA1-like protein", "type": "synonym", "evidence": [ { "id": "NP_001030412", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030412" }, { "id": "Q3SYV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3/entry#names_and_taxonomy" } ] }, { "name": "Oxidase assembly 1-like protein", "type": "synonym", "evidence": [ { "id": "Q3SYV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial inner membrane protein OXA1L", "type": "synonym", "evidence": [ { "id": "NP_001030412", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030412" } ] }, { "name": "oxidase (cytochrome c) assembly 1-like", "type": "synonym", "evidence": [ { "id": "NP_001030412", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030412" } ] }, { "name": "oxidase assembly 1-like protein", "type": "synonym", "evidence": [ { "id": "NP_001030412", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030412" } ] } ], "function": [ { "annotation": "Mitochondrial membrane insertase that mediates the cotranslational insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria.", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV3", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3#function" }, { "database": "UniProtKB", "id": "Q15070", "url": "https://www.uniprot.org/uniprotkb/Q15070#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SYV3", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OXA1L", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3", "locus": { "chromosome": "10", "start_pos": 22027169, "end_pos": 22067494, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014820", "url": "https://www.ensembl.org/id/ENSBTAG00000014820" } ] } } ], "crossref": [ { "id": "Q3SYV3", "url": "https://alphafold.ebi.ac.uk/entry/Q3SYV3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014820", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014820", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20069", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20069", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "520335", "url": "https://www.ncbi.nlm.nih.gov/gene/520335", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001708", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001708", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520335", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520335", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GWKNAQT", "url": "https://omabrowser.org/oma/group/GWKNAQT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SYV3", "url": "https://www.orthodb.org/?gene=Q3SYV3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12428", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12428", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12428:SF66", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12428:SF66", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9937383", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030412", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SYV3", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYV3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALALMCGRRQLLCLLRPQRQFHSVAGPCQWPRKPLTAGLGFPADRCLGHPRYVLLMAPGPRGLSTSAVSFGEAQVPAPPVIPATPPPTAVPEVASGEAADVIQAAAEQSFAELGLGSYTPVGLIQNLLEFMHVNLGLPWWGAIAACTVLARCLVFPLIVKGQREAAKIHNHLPEIQKFSARIREAKLTGNHTEFYRASSEMTFYQKKHDIKLFRPLILPLTQAPIFISFFIALREMANLPVPSLQTGGLWWFQDLTLSDPIYVLPLVVTATMWGVLELGAETGMQSSDLQWMRNFIRLMPLAVLPITIHFPTAVFMYWLSSNMFSLGQVACLRIPAVRTVLKIPQRVVHDPDKLAPREGFLKSFKQGWKNAEMAHQLQERERRMQNHLELAARGPLRQTFAHNPLLQHGKNDPPNTPNSSSSSSSSNKAKSKQPWRDTLG", "length": 441, "header": "sp|Q3SYV3-1|OXA1L_BOVIN Isoform 1 of Mitochondrial inner membrane protein OXA1L OS=Bos taurus OX=9913 GN=OXA1L PE=2 SV=1 CANONICAL=Q3SYV3-1" }, "isoforms": [ { "isoform_ac": "Q3SYV3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3/entry#Q3SYV3-1", "sequence": { "sequence": "MALALMCGRRQLLCLLRPQRQFHSVAGPCQWPRKPLTAGLGFPADRCLGHPRYVLLMAPGPRGLSTSAVSFGEAQVPAPPVIPATPPPTAVPEVASGEAADVIQAAAEQSFAELGLGSYTPVGLIQNLLEFMHVNLGLPWWGAIAACTVLARCLVFPLIVKGQREAAKIHNHLPEIQKFSARIREAKLTGNHTEFYRASSEMTFYQKKHDIKLFRPLILPLTQAPIFISFFIALREMANLPVPSLQTGGLWWFQDLTLSDPIYVLPLVVTATMWGVLELGAETGMQSSDLQWMRNFIRLMPLAVLPITIHFPTAVFMYWLSSNMFSLGQVACLRIPAVRTVLKIPQRVVHDPDKLAPREGFLKSFKQGWKNAEMAHQLQERERRMQNHLELAARGPLRQTFAHNPLLQHGKNDPPNTPNSSSSSSSSNKAKSKQPWRDTLG", "length": 441, "header": "sp|Q3SYV3-1|OXA1L_BOVIN Isoform 1 of Mitochondrial inner membrane protein OXA1L OS=Bos taurus OX=9913 GN=OXA1L PE=2 SV=1 CANONICAL=Q3SYV3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 364, "end_pos": 364, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV3", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3" } ], "site_lbl": "Ser364" }, { "start_pos": 400, "end_pos": 400, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV3", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3" } ], "site_lbl": "Thr400" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:520335", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520335", "resource": "KEGG Pathway" }, { "id": "R-BTA-5389840", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-9937383", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "resource": "Reactome", "description": "Mitochondrial ribosome-associated quality control" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZRH1-1", "protein_name": "OXA1L, mitochondrial inner membrane protein", "gene_name": "Oxa1l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTVSQNSWPRHVFINNSLRVIMLGTWALVEKPTITGLTSCPFPKWPLPQLQSSVCACARVSSLPGKMAMGSVCRRWQLLRLLQPPRSFHSVAGSLKPLATKLLAARSGSGRPHYALLAVLTPRCISTSAALFAEAQVQVPPVVPAASAPAAVPEVASAGPADVVQCATEQSFAELGLGSYTPVGLIQNLLEYIHVDLGLPWWGAIATCTVLARCLVFPLIVKGQREAAKIHNHMPEMQKFSARIREAKLSGDQAEFYKATIEMTHYQKKHDIKFFRPLILPLTQAPIFISFFIALREMANLPVPSLQTGGLWWFQDLTVSDPIYVLPLVVTATMWGVLELGAETGMQSSDLQLMRNVIRVMPLAVLPVTIHFPSAVFMYWLSSNVFSLCQVACLRFPAVRTALKIPQRVVHDPSKLPPREGFLKSFKKGWKNAEIAHRLREREERMQKHLDLAARGPLRQTFTHNPLLQHDPSRSPNTPNSSTNSVKANTKKPWQDTLG", "length": 499 }, "evidence": [ { "id": "Q3SYV3", "url": "https://omabrowser.org/oma/group/Q3SYV3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1QFT8-1", "protein_name": "Mitochondrial inner membrane protein OXA1L", "gene_name": "oxa1l", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAALRGRVVTECLTTCIFRQTSTPSVSTLPIVLTRNEWFVQRSHLHTGKGNRGLVRALLGCQNHGQFLLVNAVGIRHNSSQTVETTVQRVSTPSEPPDAAISAPASIPAPAVDPTPSVTPQITEQVAEAPLTALDVLQGVGAEASLSELGLCNSTPVGLIQNLLEFMHVSIGLPWWGAIVAGTIVARCAVFPVIVKGQREAAKLNNVMPEMTKLTNRMNEAKQSGNKFEFSKAYTDLMMFQKKKDVNPFRGFLVPLVQAPIFLSFFIALRKMSELPVPSLQTGGLWWFTDLTAADPFYILPIAVTGTMVAILELGAESGVDNPNLRAMKTVFRIMPFVILPLTINFPTAVFTYWMTSNLFSLAQVAVLRHPAVRQKLRIPERIVHPQSALPENEGFFATVKKGWKNAQLAQQLEERERRIKGHLDIAAKGPLRQTFTHNPLQQSAAPMSTGKPSNPNQGKKRPWEDTIG", "length": 469 }, "evidence": [ { "id": "Q3SYV3", "url": "https://omabrowser.org/oma/group/Q3SYV3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1S9B6-1", "protein_name": "OXA1L mitochondrial inner membrane protein", "gene_name": "OXA1L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAMGLMCGRRELLRLLQPQRQFHSVAGLRQWPRKPLTPGLRFPAGRRCGHPHYVLLAAPGPRGLSTSAIFYAEAQVQAPPVTPATPPPTAVPEVASGETADIVQAAAEQSFSELGLGSYTPVGLIQNLLEFMHVNLGLPWWGAIATCTVLARCLVFPLIVKGQREAAKIHNHLPEIQKFSTRIREAKLTGNHTEFYRASSEMTFYQKKHDIKLFKPLILPLTQAPIFISFFIALREMANLPVPSLQTGGLWWFQDLTLSDPTYILPLVVTATMWGVLELGAETGMQSSDLQWMRNFIRLMPLAVLPITIHFPSAVFMYWFSSNMFSLGQVLCLRIPAVRTVLKIPQRVVHDSSTLLPREGFIKSFKRGWKNAEMAHQLQERERRMQNHLELAARGPLRQTFTHNPLLQPGKNDAPVTTNSSSNKPKAKHPWRDTLG", "length": 436 }, "evidence": [ { "id": "Q3SYV3", "url": "https://omabrowser.org/oma/group/Q3SYV3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HRC8-1", "protein_name": "Mitochondrial inner membrane protein OXA1L", "gene_name": "Oxa1l", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAMSLVCGQRQLLRLLRPQRSFHSVAGSLKPLATELLVAARLGGGRPHYALLAASSPRCISTSASSSAEAQVQAPPVVPATPTPPVVPEVASGGTADAIQCAAEQSFSELGLGSYTPVGLIQNLLEFMHVDLGLPWWGAIATCTVLARCLVFPLIVKGQREAVKIHNHMPVIQKFSTQIREAKLAGDQAEFYRASIEMTRYQKKHDIKLLRPLILPLTQAPVFISFFIALREMANLPVPSLQTGGLWWFQDLTISDPIYVLPLVVTATMWGVLELGAETGVQSSDLQFMRNIIRVMPLMVLPVTIHFPSAVFMYWLSSNLFSLCQVACLRIPAVRTVLKIPQRVIHDPDTLPPREGFLKSFKTGWKKAEIAHQLQEREQRMQKHLDLAARGPLRQTFTHNPLLQHNPNHPPNTPNSSSTSSKPKSKPWHDTLG", "length": 433 }, "evidence": [ { "id": "Q3SYV3", "url": "https://omabrowser.org/oma/group/Q3SYV3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P39952-1", "protein_name": "Mitochondrial inner membrane protein OXA1", "gene_name": "OXA1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MFKLTSRLVTSRFAASSRLATARTIVLPRPHPSWISFQAKRFNSTGPNANDVSEIQTQLPSIDELTSSAPSLSASTSDLIANTTQTVGELSSHIGYLNSIGLAQTWYWPSDIIQHVLEAVHVYSGLPWWGTIAATTILIRCLMFPLYVKSSDTVARNSHIKPELDALNNKLMSTTDLQQGQLVAMQRKKLLSSHGIKNRWLAAPMLQIPIALGFFNALRHMANYPVDGFANQGVAWFTDLTQADPYLGLQVITAAVFISFTRLGGETGAQQFSSPMKRLFTILPIISIPATMNLSSAVVLYFAFNGAFSVLQTMILRNKWVRSKLKITEVAKPRTPIAGASPTENMGIFQSLKHNIQKARDQAERRQLMQDNEKKLQESFKEKRQNSKIKIVHKSNFINNKK", "length": 402 }, "evidence": [ { "id": "Q3SYV3", "url": "https://omabrowser.org/oma/group/Q3SYV3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q15070-1", "protein_name": "Mitochondrial inner membrane protein OXA1L", "gene_name": "OXA1L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAMGLMCGRRELLRLLQSGRRVHSVAGPSQWLGKPLTTRLLFPAAPCCCRPHYLFLAASGPRSLSTSAISFAEVQVQAPPVVAATPSPTAVPEVASGETADVVQTAAEQSFAELGLGSYTPVGLIQNLLEFMHVDLGLPWWGAIAACTVFARCLIFPLIVTGQREAARIHNHLPEIQKFSSRIREAKLAGDHIEYYKASSEMALYQKKHGIKLYKPLILPVTQAPIFISFFIALREMANLPVPSLQTGGLWWFQDLTVSDPIYILPLAVTATMWAVLELGAETGVQSSDLQWMRNVIRMMPLITLPITMHFPTAVFMYWLSSNLFSLVQVSCLRIPAVRTVLKIPQRVVHDLDKLPPREGFLESFKKGWKNAEMTRQLREREQRMRNQLELAARGPLRQTFTHNPLLQPGKDNPPNIPSSSSKPKSKYPWHDTLG", "length": 435 }, "evidence": [ { "id": "Q3SYV3", "url": "https://omabrowser.org/oma/group/Q3SYV3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BGA9-1", "protein_name": "Mitochondrial inner membrane protein OXA1L", "gene_name": "Oxa1l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARNLVCGRWQLLRLLRPQRSYHSVAVSLRPLAAELLAARRGNGRPPCALLAVFTPRCISTSATLFAEAQVQAPPVIPATSIPAAVPEVASGGAADVVQCATEPSFTELGLGSYTPVGLIQNLLEYIHVDLGLPWWGAIATCTVLARCLVFPLIVKGQREAAKIHNHMPEMQKFSARIREAKLAGDQAEFYKATIEMTRYQKKHDIKLLRPLILPLTQAPVFISFFIALREMANLPVPSLQTGGLWWFQDLTVSDPIYVLPLVVTATMWCVLELGAETGVQSNDLQFMRNIIRVMPLVVLPVTIHFPSAVFMYWLSSNVFSLCQVACLRIPAVRTVLKIPQRVVHDPDKLPPREGFLKSFKKGWKNAEIAQQLREREQRMQKHLDLAARGPLRQTFTHNPLLQHDPSHPPKAPNSNNSSIKANAKKPWQDTLG", "length": 433 }, "evidence": [ { "id": "Q3SYV3", "url": "https://omabrowser.org/oma/group/Q3SYV3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV3", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV3", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV3", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3" } ], "pmid": "" }, { "name": "mitochondrial ribosome binding", "id": "GO:0097177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097177", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV3", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3" } ], "pmid": "" }, { "name": "membrane insertase activity", "id": "GO:0032977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032977", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV3", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein tetramerization", "id": "GO:0051262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051262", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV3", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3" } ], "pmid": "" }, { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV3", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3" } ], "pmid": "" }, { "name": "protein insertion into mitochondrial inner membrane from matrix", "id": "GO:0032979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032979", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV3", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3" } ], "pmid": "" }, { "name": "mitochondrial protein quality control", "id": "GO:0141164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141164", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV3", "url": "https://www.uniprot.org/uniprotkb/Q3SYV3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 191, "end_pos": 193, "annotation": "n_glycosylation_sequon" }, { "start_pos": 419, "end_pos": 421, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SYV3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 441, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SYV3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SYV3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 364, 400 ], "sequon_annotation_sites": [ { "start_pos": 191, "end_pos": 193 }, { "start_pos": 419, "end_pos": 421 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SYV4-1", "uniprot_ac": "Q3SYV4", "uniprot_id": "CAP1_BOVIN", "mass": { "chemical_mass": 51273.0, "monoisotopic_mass": 51273.0 }, "refseq": { "ac": "NP_001030182", "name": "adenylyl cyclase-associated protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030182" }, "gene_names": [ { "name": "CAP1", "type": "recommended", "evidence": [ { "id": "Q3SYV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYV4" } ] }, { "name": "CAP1", "type": "synonym", "evidence": [ { "id": "NP_001030182", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030182" } ] } ], "protein_names": [ { "name": "Adenylyl cyclase-associated protein 1", "type": "recommended", "evidence": [ { "id": "Q3SYV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYV4/entry#names_and_taxonomy" } ] }, { "name": "CAP 1", "type": "synonym", "evidence": [ { "id": "NP_001030182", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030182" }, { "id": "Q3SYV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYV4/entry#names_and_taxonomy" } ] }, { "name": "CAP, adenylate cyclase-associated protein 1", "type": "synonym", "evidence": [ { "id": "NP_001030182", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030182" } ] }, { "name": "adenylate cyclase associated protein 1", "type": "synonym", "evidence": [ { "id": "NP_001030182", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030182" } ] }, { "name": "adenylyl cyclase-associated protein 1", "type": "synonym", "evidence": [ { "id": "NP_001030182", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030182" } ] } ], "function": [ { "annotation": "Bovine herpesvirus 1 infection stimulates caspase 1 activity.", "evidence": [ { "database": "RefSeq", "id": "NP_001030182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030182" }, { "database": "PubMed", "id": "24657787", "url": "https://glygen.org/publication/PubMed/24657787" } ] }, { "annotation": "Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV4", "url": "https://www.uniprot.org/uniprotkb/Q3SYV4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SYV4", "url": "https://www.uniprot.org/uniprotkb/Q3SYV4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CAP1", "url": "https://www.uniprot.org/uniprotkb/Q3SYV4", "locus": { "chromosome": "3", "start_pos": 106037116, "end_pos": 106066200, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013363", "url": "https://www.ensembl.org/id/ENSBTAG00000013363" } ] } } ], "crossref": [ { "id": "Q3SYV4", "url": "https://alphafold.ebi.ac.uk/entry/Q3SYV4", "database": "AlphaFoldDB", "categories": [] }, { "id": "504519", "url": "https://www.ncbi.nlm.nih.gov/gene/504519", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001837", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001837", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013912", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013912", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017901", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017901", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036223", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036223", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053950", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053950", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504519", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504519", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SYV4", "url": "https://www.orthodb.org/?gene=Q3SYV4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10652", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10652", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10652:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10652:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01213", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01213", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08603", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08603", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21938", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21938", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030182", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SYV4", "url": "https://www.uniprot.org/uniprotkb/Q3SYV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SYV4-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYV4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADMRNLVERLERVVGRLEAVSHASDTHCGYGDSAAKAGTTPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLERALLVTASQCQQPAGNKLSDLLAPISEQIQEVVTFREKNRGSKLFNHLSAVSESIQALGWVAMAPKPGPYVKEMNDAAMFYTNRVLKEYKDVDKKHVDWVKAYLSIWTELQAYIKEFHTTGLAWSRTGPVAKELSGLPSGPSAGSGPPPPPPGPPPPPVPTSSGSDDSASRSALFAQINQGESITHALKHVSDDMKTHKNPALKAQSGLIRSGPKPFSASKPDPPKPVAKKEPALLELEGKKWRVENQENVSNLMIEDTELKQVAYIFKCVNSTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSKDVKVQVMGKVPTISINKTDGCHVYLSKNSLDCEIVSAKSSEMNVLIPTEGGDFNEFPVPEQFKTLWNGQKLVTTVTEIAG", "length": 472, "header": "sp|Q3SYV4-1|CAP1_BOVIN Isoform 1 of Adenylyl cyclase-associated protein 1 OS=Bos taurus OX=9913 GN=CAP1 PE=2 SV=3 CANONICAL=Q3SYV4-1" }, "isoforms": [ { "isoform_ac": "Q3SYV4-1", "url": "https://www.uniprot.org/uniprotkb/Q3SYV4/entry#Q3SYV4-1", "sequence": { "sequence": "MADMRNLVERLERVVGRLEAVSHASDTHCGYGDSAAKAGTTPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLERALLVTASQCQQPAGNKLSDLLAPISEQIQEVVTFREKNRGSKLFNHLSAVSESIQALGWVAMAPKPGPYVKEMNDAAMFYTNRVLKEYKDVDKKHVDWVKAYLSIWTELQAYIKEFHTTGLAWSRTGPVAKELSGLPSGPSAGSGPPPPPPGPPPPPVPTSSGSDDSASRSALFAQINQGESITHALKHVSDDMKTHKNPALKAQSGLIRSGPKPFSASKPDPPKPVAKKEPALLELEGKKWRVENQENVSNLMIEDTELKQVAYIFKCVNSTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSKDVKVQVMGKVPTISINKTDGCHVYLSKNSLDCEIVSAKSSEMNVLIPTEGGDFNEFPVPEQFKTLWNGQKLVTTVTEIAG", "length": 472, "header": "sp|Q3SYV4-1|CAP1_BOVIN Isoform 1 of Adenylyl cyclase-associated protein 1 OS=Bos taurus OX=9913 GN=CAP1 PE=2 SV=3 CANONICAL=Q3SYV4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 290, "end_pos": 290, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SYV4", "url": "https://www.uniprot.org/uniprotkb/Q3SYV4" } ], "site_lbl": "Ser290" }, { "start_pos": 295, 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Biol. 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DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SYX6", "url": "https://www.uniprot.org/uniprotkb/Q3SYX6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SYX6", "url": "https://www.uniprot.org/uniprotkb/Q3SYX6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SUPT4H1", "url": "https://www.uniprot.org/uniprotkb/Q3SYX6", "locus": { "chromosome": "19", "start_pos": 9314438, "end_pos": 9320203, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000063664", "url": "https://www.ensembl.org/id/ENSBTAG00000063664" } ] } } ], "crossref": [ { "id": "Q3SYX6", "url": "https://alphafold.ebi.ac.uk/entry/Q3SYX6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07973", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07973", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616425", "url": "https://www.ncbi.nlm.nih.gov/gene/616425", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022800", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022800", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029040", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029040", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038510", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038510", "database": "InterPro", "categories": [ "Protein 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"start_pos": 9320174, "end_pos": 9315657, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089056.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089056.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093554.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093554.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q3SYX6", "url": "https://www.uniprot.org/uniprotkb/Q3SYX6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:616425", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616425", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "DSIF complex", "id": "GO:0032044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032044", "evidence": [ { "database": "UniProtKB", "id": "Q3SYX6", "url": "https://www.uniprot.org/uniprotkb/Q3SYX6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "negative regulation of DNA-templated transcription, elongation", "id": "GO:0032785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032785", "evidence": [ { "database": "UniProtKB", "id": "Q3SYX6", "url": "https://www.uniprot.org/uniprotkb/Q3SYX6" } ], "pmid": "" }, { "name": "regulation of transcription elongation by RNA polymerase II", "id": "GO:0034243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034243", "evidence": [ { "database": "UniProtKB", "id": "Q3SYX6", "url": 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"https://omabrowser.org/oma/group/Q3SYZ9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VS38-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 4", "gene_name": "MED4", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSFHLSTKERLLLLIDDIEMIAKELIEQAHQKISSTELVDLLDLLVAKDEEFRKMLELAEEQAKVEEAMDQLRAKVEVHDREIQKLQKSLKDAELILSTAIFQARQKLASINQANKRPVSSEELIKYAHRISSANAVSAPLTWCIGDLRRPYPTDIEMRNGLLGKSEQNINGGTVTHQNSGMPSEQQRTLSGSAGSGSGSGAGGEVPNAFQNQFNWNLGELHMTMGASGNTVALETRAQDDVEVMSTDSSSSSSSDSQ", "length": 258 }, "evidence": [ { "id": "Q3SYZ9", "url": "https://omabrowser.org/oma/group/Q3SYZ9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of transcription initiation by RNA polymerase II", "id": "GO:0060261", "url": 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{ "name": "nuclear thyroid hormone receptor binding", "id": "GO:0046966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046966", "evidence": [ { "database": "UniProtKB", "id": "Q3SYZ9", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ9" } ], "pmid": "" }, { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "Q3SYZ9", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3SYZ9", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ9" } ], "pmid": "" }, { "name": "mediator complex", "id": "GO:0016592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "evidence": [ { "database": "UniProtKB", "id": "Q3SYZ9", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ9" } ], "pmid": "" }, { "name": "core mediator complex", "id": "GO:0070847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070847", "evidence": [ { "database": "UniProtKB", "id": "Q3SYZ9", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 235, "end_pos": 237, "annotation": "n_glycosylation_sequon" }, { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SYZ9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 270, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SYZ9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SYZ9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 32 ], "sequon_annotation_sites": [ { "start_pos": 235, "end_pos": 237 }, { "start_pos": 24, "end_pos": 26 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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"count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ25-1", "uniprot_ac": "Q3SZ25", "uniprot_id": "EED_BOVIN", "mass": { "chemical_mass": 50226.0, "monoisotopic_mass": 50226.0 }, "refseq": { "ac": "NP_001035584", "name": "polycomb protein EED", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035584" }, "gene_names": [ { "name": "EED", "type": "recommended", "evidence": [ { "id": "Q3SZ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ25" } ] }, { "name": "EED", "type": "synonym", "evidence": [ { "id": "NP_001035584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035584" } ] } ], "protein_names": [ { "name": "Polycomb protein EED", "type": "recommended", "evidence": [ { "id": "Q3SZ25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ25/entry#names_and_taxonomy" } ] }, { "name": "embryonic ectoderm development protein", "type": "synonym", "evidence": [ { "id": "NP_001035584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035584" } ] }, { "name": "polycomb protein EED", "type": "synonym", "evidence": [ { "id": "NP_001035584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035584" } ] } ], "function": [ { "annotation": "Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ25", "url": "https://www.uniprot.org/uniprotkb/Q3SZ25#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ25", "url": "https://www.uniprot.org/uniprotkb/Q3SZ25" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EED", "url": "https://www.uniprot.org/uniprotkb/Q3SZ25", "locus": { "chromosome": "29", "start_pos": 9265442, "end_pos": 9296348, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007847", "url": "https://www.ensembl.org/id/ENSBTAG00000007847" } ] } } ], "crossref": [ { "id": "Q3SZ25", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ25", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007847", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007847", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "404183", "url": "https://www.ncbi.nlm.nih.gov/gene/404183", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051243", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051243", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:404183", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404183", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RDVHRNY", "url": "https://omabrowser.org/oma/group/RDVHRNY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ25", "url": "https://www.orthodb.org/?gene=Q3SZ25", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10253", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10253", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212300", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212300", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559580", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3214841", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214841", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8943724", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8943724", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8953750", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8953750", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9764725", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9764725", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9909649", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9909649", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001035584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035584", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZ25", "url": "https://www.uniprot.org/uniprotkb/Q3SZ25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ25-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ25-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEREVSTVPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR", "length": 441, "header": "sp|Q3SZ25-1|EED_BOVIN Isoform 1 of Polycomb protein EED OS=Bos taurus OX=9913 GN=EED PE=2 SV=1 CANONICAL=Q3SZ25-1" }, "isoforms": [ { "isoform_ac": "Q3SZ25-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ25/entry#Q3SZ25-1", "sequence": { "sequence": "MSEREVSTVPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR", "length": 441, "header": "sp|Q3SZ25-1|EED_BOVIN Isoform 1 of Polycomb protein EED OS=Bos taurus OX=9913 GN=EED PE=2 SV=1 CANONICAL=Q3SZ25-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 2, "end_pos": 2, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ25", "url": "https://www.uniprot.org/uniprotkb/Q3SZ25" } ], "site_lbl": "Ser2" }, { "start_pos": 34, "end_pos": 34, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ25", "url": "https://www.uniprot.org/uniprotkb/Q3SZ25" } ], "site_lbl": "Ser34" }, { "start_pos": 55, "end_pos": 55, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ25", "url": "https://www.uniprot.org/uniprotkb/Q3SZ25" } ], "site_lbl": "Thr55" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:404183", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404183", "resource": "KEGG Pathway" }, { "id": "R-BTA-212300", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212300", "resource": "Reactome", "description": "PRC2 methylates histones and DNA" }, { "id": "R-BTA-2559580", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559580", "resource": "Reactome", "description": "Oxidative Stress Induced Senescence" }, { "id": "R-BTA-3214841", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214841", "resource": "Reactome", "description": "PKMTs methylate histone lysines" }, { "id": "R-BTA-8943724", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8943724", "resource": "Reactome", "description": "Regulation of PTEN gene transcription" }, { "id": "R-BTA-8953750", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8953750", "resource": "Reactome", "description": "Transcriptional Regulation by E2F6" }, { "id": "R-BTA-9764725", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9764725", "resource": "Reactome", "description": "Negative Regulation of CDH1 Gene Transcription" }, { "id": "R-BTA-9909649", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9909649", "resource": "Reactome", "description": "Regulation of PD-L1(CD274) transcription" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8J8YPE2-1", "protein_name": "Polycomb protein EED", "gene_name": "Eed", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "VAGSHARPPRRLGAICDSGGSGGGGGAGSFAAGSGRACLTAVWRRPRPRRQEPGGRRRNMSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR", "length": 500 }, "evidence": [ { "id": "Q3SZ25", "url": "https://omabrowser.org/oma/group/Q3SZ25/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O75530-1", "protein_name": "Polycomb protein EED", "gene_name": "EED", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR", "length": 441 }, "evidence": [ { "id": "Q3SZ25", "url": "https://omabrowser.org/oma/group/Q3SZ25/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q566T0-1", "protein_name": "Polycomb protein eed", "gene_name": "eed", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKMRRKMSEPHGEAGNEMPNKKQKLSSDENSNPDLSGDDNDDAVSVESGTHPERPDTPTNTASAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHGQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTFDCSSSHPLLAVAGSRGIIRIINHITMQCVKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADFDLLGEKIMSCGMDHSLKLWRLDSERLQRAIRGSYEYNPSKTNRPFVSQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGRMEDDIDRIKPNESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTLPRCTSAIRQTSFSRDSSILIAVCDDASIWRWDRLR", "length": 443 }, "evidence": [ { "id": "Q3SZ25", "url": "https://omabrowser.org/oma/group/Q3SZ25/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q921E6-1", "protein_name": "Polycomb protein EED", "gene_name": "Eed", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR", "length": 441 }, "evidence": [ { "id": "Q3SZ25", "url": "https://omabrowser.org/oma/group/Q3SZ25/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9LT47-1", "protein_name": "Polycomb group protein FERTILIZATION-INDEPENDENT ENDOSPERM", "gene_name": "FIE", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSKITLGNESIVGSLTPSNKKSYKVTNRIQEGKKPLYAVVFNFLDARFFDVFVTAGGNRITLYNCLGDGAISALQSYADEDKEESFYTVSWACGVNGNPYVAAGGVKGIIRVIDVNSETIHKSLVGHGDSVNEIRTQPLKPQLVITASKDESVRLWNVETGICILIFAGAGGHRYEVLSVDFHPSDIYRFASCGMDTTIKIWSMKEFWTYVEKSFTWTDDPSKFPTKFVQFPVFTASIHTNYVDCNRWFGDFILSKSVDNEILLWEPQLKENSPGEGASDVLLRYPVPMCDIWFIKFSCDLHLSSVAIGNQEGKVYVWDLKSCPPVLITKLSHNQSKSVIRQTAMSVDGSTILACCEDGTIWRWDVITK", "length": 369 }, "evidence": [ { "id": "Q3SZ25", "url": "https://omabrowser.org/oma/group/Q3SZ25/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VKD5-1", "protein_name": "Polycomb protein esc", "gene_name": "escl", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTETNPSEISPPSEEPPAEDESTDHSPAEAVLSNNSSSVCNVVEPDDEHEVNSVDREDTASLFSTTTTTTRSKSPNTRKLNRLCRRIKAPKMVQPLYKYSSHVREDHNHQIFGVQFNPFLDRGQPQVFATVGKDRVSIYECERSTGQESCEGIRLLQVYADPDTDESFYTCAWSYDSVTGDPVLAAAGYRGVIRIFNPVKHQCSKNYIGHGHAINELKFHPTRPQLLLSGSKDHSLRLWNIQSDVCVAVFGGVEGHRDEVLSVDFDLRGDRIMSSGMDHSLKLWRLDKPDIKEAIELSSGFSPNKNTGPFPTIKEHFPDFSTRDIHRNYVDCVQWFGDFVFSKSCENSIVCWKPGKLSESWHEIKPQESATTVLHHFDYKMCEIWFVRFAFNAWQKILALGNQLGTTFVWELDCNDPNLTKCSQLVHPKSNSTIRQTSFSKDGSILVCVCDDSTVWRWDRVN", "length": 462 }, "evidence": [ { "id": "Q3SZ25", "url": "https://omabrowser.org/oma/group/Q3SZ25/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ25", "url": "https://www.uniprot.org/uniprotkb/Q3SZ25" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ25", "url": "https://www.uniprot.org/uniprotkb/Q3SZ25" } ], "pmid": "" }, { "name": "heterochromatin formation", "id": "GO:0031507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031507", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ25", "url": "https://www.uniprot.org/uniprotkb/Q3SZ25" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "enzyme activator activity", "id": "GO:0008047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008047", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ25", "url": "https://www.uniprot.org/uniprotkb/Q3SZ25" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "ESC/E(Z) complex", "id": "GO:0035098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035098", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ25", "url": "https://www.uniprot.org/uniprotkb/Q3SZ25" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 349, "end_pos": 351, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ25-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 441, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ25-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ25" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 2, 34, 55 ], "sequon_annotation_sites": [ { "start_pos": 157, "end_pos": 159 }, { "start_pos": 283, "end_pos": 285 }, { "start_pos": 349, "end_pos": 351 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ26-1", "uniprot_ac": "Q3SZ26", "uniprot_id": "GET1_BOVIN", "mass": { "chemical_mass": 19843.0, "monoisotopic_mass": 19843.0 }, "refseq": { "ac": "NP_001029531", "name": "guided entry of tail-anchored proteins factor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029531" }, "gene_names": [ { "name": "GET1", "type": "recommended", "evidence": [ { "id": "Q3SZ26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ26" } ] }, { "name": "GET1", "type": "synonym", "evidence": [ { "id": "NP_001029531", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029531" } ] }, { "name": "WRB", "type": "synonym", "evidence": [ { "id": "NP_001029531", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029531" }, { "id": "Q3SZ26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ26" } ] } ], "protein_names": [ { "name": "Guided entry of tail-anchored proteins factor 1", "type": "recommended", "evidence": [ { "id": "Q3SZ26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ26/entry#names_and_taxonomy" } ] }, { "name": "Tail-anchored protein insertion receptor WRB", "type": "synonym", "evidence": [ { "id": "Q3SZ26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ26/entry#names_and_taxonomy" } ] }, { "name": "Tryptophan-rich basic protein", "type": "synonym", "evidence": [ { "id": "Q3SZ26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ26/entry#names_and_taxonomy" } ] }, { "name": "guided entry of tail-anchored proteins factor 1", "type": "synonym", "evidence": [ { "id": "NP_001029531", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029531" } ] }, { "name": "tail-anchored protein insertion receptor WRB", "type": "synonym", "evidence": [ { "id": "NP_001029531", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029531" } ] }, { "name": "tryptophan rich basic protein", "type": "synonym", "evidence": [ { "id": "NP_001029531", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029531" } ] }, { "name": "tryptophan-rich protein", "type": "synonym", "evidence": [ { "id": "NP_001029531", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029531" } ] } ], "function": [ { "annotation": "Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required to ensure correct topology and ER insertion of CAMLG.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ26", "url": "https://www.uniprot.org/uniprotkb/Q3SZ26#function" }, { "database": "UniProtKB", "id": "O00258", "url": "https://www.uniprot.org/uniprotkb/O00258#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ26", "url": "https://www.uniprot.org/uniprotkb/Q3SZ26" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GET1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ26", "locus": { "chromosome": "1", "start_pos": 139458044, "end_pos": 139442827, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013629", "url": "https://www.ensembl.org/id/ENSBTAG00000013629" } ] } } ], "crossref": [ { "id": "Q3SZ26", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ26", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013629", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013629", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "509739", "url": "https://www.ncbi.nlm.nih.gov/gene/509739", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028945", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028945", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509739", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509739", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AEWIISF", "url": "https://omabrowser.org/oma/group/AEWIISF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR42650", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42650", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42650:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42650:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04420", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04420", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029531", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZ26", "url": "https://www.uniprot.org/uniprotkb/Q3SZ26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ26-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ26-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAAEADRWAWLLVLSFVFGCNVLRILLPSFSFFMSRVLQKDAEQESQMRAEIQGMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYILQAALMVSLIWKYYSVPVAVVPSKWITPLDRLVAFPTRVAGGVGITCWILVCNKVVAIVLHPFS", "length": 174, "header": "sp|Q3SZ26-1|GET1_BOVIN Isoform 1 of Guided entry of tail-anchored proteins factor 1 OS=Bos taurus OX=9913 GN=GET1 PE=2 SV=1 CANONICAL=Q3SZ26-1" }, "isoforms": [ { "isoform_ac": "Q3SZ26-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ26/entry#Q3SZ26-1", "sequence": { "sequence": "MSAAEADRWAWLLVLSFVFGCNVLRILLPSFSFFMSRVLQKDAEQESQMRAEIQGMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYILQAALMVSLIWKYYSVPVAVVPSKWITPLDRLVAFPTRVAGGVGITCWILVCNKVVAIVLHPFS", "length": 174, "header": "sp|Q3SZ26-1|GET1_BOVIN Isoform 1 of Guided entry of tail-anchored proteins factor 1 OS=Bos taurus OX=9913 GN=GET1 PE=2 SV=1 CANONICAL=Q3SZ26-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509739", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509739", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZQQ5-1", "protein_name": "Guided entry of tail-anchored proteins factor 1", "gene_name": "GET1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSAAEADRWAWLLVLSFVFGCNVLRILLPSFSSFMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYILQAALMVSLIWKYYSVPVAVVPRKWITPLDRLVAFPTRVAGGVGITCWILVCNKVVAIVLHPFS", "length": 174 }, "evidence": [ { "id": "Q3SZ26", "url": "https://omabrowser.org/oma/group/Q3SZ26/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F6R8U4-1", "protein_name": "Guided entry of tail-anchored proteins factor 1", "gene_name": "WRB", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAESGAWLLVLSAVFLCNALKILLPSCSSIISKLLQKDAEQESQMRAEIQNMKQELSTISMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVINIVFYILQAALMISLIWKYYSEPVTVLPSKWLAPLERLVAFPTGVAGGVGITCWLVVCNKVVAIMLHPFS", "length": 170 }, "evidence": [ { "id": "Q3SZ26", "url": "https://omabrowser.org/oma/group/Q3SZ26/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O00258-1", "protein_name": "Guided entry of tail-anchored proteins factor 1", "gene_name": "GET1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYVLQAALMISLIWKYYSVPVAVVPSKWITPLDRLVAFPTRVAGGVGITCWILVCNKVVAIVLHPFS", "length": 174 }, "evidence": [ { "id": "Q3SZ26", "url": "https://omabrowser.org/oma/group/Q3SZ26/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6DRM0-1", "protein_name": "Guided entry of tail-anchored proteins factor 1", "gene_name": "get1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAAGFNWFLVLSSVFLCNLVKTFLPSISSFLSKIFHKDADQEMEMRTEIQNMKMELSTISMMDEFARYARLERKINKMTDQLKTLVKSRTAQQAKMKWIVNIAFYILQAALMISLILKYYADPVTVVPSKWIAPLERLVAFPSGVAGGVGITCWLVVCNKVVALILQAVS", "length": 170 }, "evidence": [ { "id": "Q3SZ26", "url": "https://omabrowser.org/oma/group/Q3SZ26/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8K0D7-1", "protein_name": "Guided entry of tail-anchored proteins factor 1", "gene_name": "Get1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSASETDRWAWLLVLSFVFGCNLLRILLPSLSSFISRVLQKDAEQESQMRAEIQGMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWFISVAFYILQAALMISLIWKYYSVPVAVVPSKWITPLDRLVAFPTRVAGGIGITCWILVCNKVVAIVLHPFS", "length": 174 }, "evidence": [ { "id": "Q3SZ26", "url": "https://omabrowser.org/oma/group/Q3SZ26/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ26", "url": "https://www.uniprot.org/uniprotkb/Q3SZ26" } ], "pmid": "" }, { "name": "GET complex", "id": "GO:0043529", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043529", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ26", "url": "https://www.uniprot.org/uniprotkb/Q3SZ26" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-membrane adaptor activity", "id": "GO:0043495", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043495", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ26", "url": "https://www.uniprot.org/uniprotkb/Q3SZ26" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "tail-anchored membrane protein insertion into ER membrane", "id": "GO:0071816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071816", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ26", "url": "https://www.uniprot.org/uniprotkb/Q3SZ26" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ26-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 174, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ26-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ26" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ36-1", "uniprot_ac": "Q3SZ36", "uniprot_id": "TMM18_BOVIN", "mass": { "chemical_mass": 16053.0, "monoisotopic_mass": 16053.0 }, "refseq": { "ac": "NP_001029965", "name": "transmembrane protein 18", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029965" }, "gene_names": [ { "name": "TMEM18", "type": "recommended", "evidence": [ { "id": "Q3SZ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ36" } ] }, { "name": "TMEM18", "type": "synonym", "evidence": [ { "id": "NP_001029965", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029965" } ] } ], "protein_names": [ { "name": "Transmembrane protein 18", "type": "recommended", "evidence": [ { "id": "Q3SZ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ36/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 18", "type": "synonym", "evidence": [ { "id": "NP_001029965", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029965" } ] } ], "function": [ { "annotation": "Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC) (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ36", "url": "https://www.uniprot.org/uniprotkb/Q3SZ36#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ36", "url": "https://www.uniprot.org/uniprotkb/Q3SZ36" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM18", "url": "https://www.uniprot.org/uniprotkb/Q3SZ36", "locus": { "chromosome": "8", "start_pos": 112477324, "end_pos": 112472794, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057706", "url": "https://www.ensembl.org/id/ENSBTAG00000057706" } ] } } ], "crossref": [ { "id": "Q3SZ36", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ36", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050718", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050718", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616554", "url": "https://www.ncbi.nlm.nih.gov/gene/616554", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026721", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026721", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616554", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616554", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TFSKQQY", "url": "https://omabrowser.org/oma/group/TFSKQQY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ36", "url": "https://www.orthodb.org/?gene=Q3SZ36", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22593", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22593", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22593:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22593:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14770", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14770", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029965", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029965", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZ36", "url": "https://www.uniprot.org/uniprotkb/Q3SZ36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ36-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ36-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSAFSVSRFPVSIPAVITQTDWTEPWLVGLAGFHVLCLLLTCFSSQRYRLQVGHFLCLVTLVYCAEYINEVAAMNWRLFSKHQYFDSRGMFISLVFSAPLLLNALVIVVLWVRKTLVVMTDLRSLREQRRARARPKEE", "length": 139, "header": "sp|Q3SZ36-1|TMM18_BOVIN Isoform 1 of Transmembrane protein 18 OS=Bos taurus OX=9913 GN=TMEM18 PE=2 SV=1 CANONICAL=Q3SZ36-1" }, "isoforms": [ { "isoform_ac": "Q3SZ36-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ36/entry#Q3SZ36-1", "sequence": { "sequence": "MPSAFSVSRFPVSIPAVITQTDWTEPWLVGLAGFHVLCLLLTCFSSQRYRLQVGHFLCLVTLVYCAEYINEVAAMNWRLFSKHQYFDSRGMFISLVFSAPLLLNALVIVVLWVRKTLVVMTDLRSLREQRRARARPKEE", "length": 139, "header": "sp|Q3SZ36-1|TMM18_BOVIN Isoform 1 of Transmembrane protein 18 OS=Bos taurus OX=9913 GN=TMEM18 PE=2 SV=1 CANONICAL=Q3SZ36-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616554", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616554", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A1Z903-1", "protein_name": "Transmembrane protein 18", "gene_name": "Tmem18", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MHPGQIEVNEINGYWTFLLSIDWKDPWLIGLILAHILTTTTALLSRNSSNFQVFLFLVLLLAVYFTESINEFAANNWSSFSRQQYFDSNGLFISTVFSIPILLNCMLLIGTWLYNSTQLMVTLKTAQLKERARKERQTKADSESIAHKKAE", "length": 151 }, "evidence": [ { "id": "Q3SZ36", "url": "https://omabrowser.org/oma/group/Q3SZ36/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "G3HBH6-1", "protein_name": "Transmembrane protein 18", "gene_name": "Tmem18", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPSPFSVKAFPVSIPAVIMETDWTEPWLLGLVVFHLLCLLLTCFSSQRYKLQIGHFLCLVLLVYFAEYINEVAAMNWRSFSKYQYFDSRGMFISIVFSAPLLFNAMIIVIMWVQKTLNVMSDLKRMQEKRKRRRKEE", "length": 137 }, "evidence": [ { "id": "Q3SZ36", "url": "https://omabrowser.org/oma/group/Q3SZ36/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q3TUD9-1", "protein_name": "Transmembrane protein 18", "gene_name": "Tmem18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSAYSVRSFPVSIPAVIMETDWTEPWLLGLLAFHLLCLLLTCFSSQRYKLQIGHFLCLVVLVYSAEYINEVAAVNWRLFSKYQYFDSRGMFISLVFSAPLLFNAMLIVIMWVRKTLTVMTDLKTLQEERKERRRRRKEE", "length": 140 }, "evidence": [ { "id": "Q3SZ36", "url": "https://omabrowser.org/oma/group/Q3SZ36/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5F410-1", "protein_name": "Transmembrane protein 18", "gene_name": "TMEM18", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRSVAVAMEQPLHGPPGLSTILARTDWAEPWLLGLAGFHVLCFLLTCFSFQHYRVQIGHFLCMVCLVYCAEYINELAAMNWRLFSKYQYFDSRGMFISLVFSAPLLVNTIIIVVNWVYRTLNVMTELKTLQQRIKAEKDKKK", "length": 142 }, "evidence": [ { "id": "Q3SZ36", "url": "https://omabrowser.org/oma/group/Q3SZ36/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q641M3-1", "protein_name": "Transmembrane protein 18", "gene_name": "tmem18", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTASNTKNASAIPIDKFSNVRITSIWTFLQSVDWSEPWLMALLAFHVFCFAFTLLSCKYYRIQICHFLLMVAMVYSAEYLNELAAMNWRSFSKFQYFDSKGMFISLVYSVPLLLNTVIIVAVWVWRTFSTMTELKILQLKRKAARENHKKTQ", "length": 152 }, "evidence": [ { "id": "Q3SZ36", "url": "https://omabrowser.org/oma/group/Q3SZ36/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q96B42-1", "protein_name": "Transmembrane protein 18", "gene_name": "TMEM18", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPSAFSVSSFPVSIPAVLTQTDWTEPWLMGLATFHALCVLLTCLSSRSYRLQIGHFLCLVILVYCAEYINEAAAMNWRLFSKYQYFDSRGMFISIVFSAPLLVNAMIIVVMWVWKTLNVMTDLKNAQERRKEKKRRRKED", "length": 140 }, "evidence": [ { "id": "Q3SZ36", "url": "https://omabrowser.org/oma/group/Q3SZ36/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ36", "url": "https://www.uniprot.org/uniprotkb/Q3SZ36" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ36", "url": "https://www.uniprot.org/uniprotkb/Q3SZ36" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ36", "url": "https://www.uniprot.org/uniprotkb/Q3SZ36" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ36", "url": "https://www.uniprot.org/uniprotkb/Q3SZ36" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ36", "url": "https://www.uniprot.org/uniprotkb/Q3SZ36" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ36-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 139, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ36-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ36" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SZ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ36" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Nuclear localization signal", "eco_id": "ECO_0000250", "start_pos": 130, "end_pos": 138, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ40-1", "uniprot_ac": "Q3SZ40", "uniprot_id": "DDX56_BOVIN", "mass": { "chemical_mass": 61254.0, "monoisotopic_mass": 61254.0 }, "refseq": { "ac": "NP_001029501", "name": "probable ATP-dependent RNA helicase DDX56", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029501" }, "gene_names": [ { "name": "DDX56", "type": "recommended", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] }, { "name": "DDX56", "type": "synonym", "evidence": [ { "id": "NP_001029501", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029501" } ] } ], "protein_names": [ { "name": "Probable ATP-dependent RNA helicase DDX56", "type": "recommended", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40/entry#names_and_taxonomy" } ] }, { "name": "3.6.4.13", "type": "synonym", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40/entry#names_and_taxonomy" } ] }, { "name": "DEAD (Asp-Glu-Ala-Asp) box helicase 56", "type": "synonym", "evidence": [ { "id": "NP_001029501", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029501" } ] }, { "name": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 56", "type": "synonym", "evidence": [ { "id": "NP_001029501", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029501" } ] }, { "name": "DEAD box protein 56", "type": "synonym", "evidence": [ { "id": "NP_001029501", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029501" }, { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40/entry#names_and_taxonomy" } ] }, { "name": "probable ATP-dependent RNA helicase DDX56", "type": "synonym", "evidence": [ { "id": "NP_001029501", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029501" } ] } ], "function": [ { "annotation": "Nucleolar RNA helicase that plays a role in various biological processes including innate immunity, ribosome biogenesis or nucleolus organization. Plays an essential role in maintaining nucleolar integrity in planarian stem cells (By similarity). Maintains embryonic stem cells proliferation by conventional regulation of ribosome assembly and interaction with OCT4 and POU5F1 complex (By similarity). Regulates antiviral innate immunity by inhibiting the virus-triggered signaling nuclear translocation of IRF3. Mechanistically, acts by disrupting the interaction between IRF3 and importin IPO5. May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ40", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40#function" }, { "database": "UniProtKB", "id": "Q9NY93", "url": "https://www.uniprot.org/uniprotkb/Q9NY93#function" }, { "database": "UniProtKB", "id": "Q9D0R4", "url": "https://www.uniprot.org/uniprotkb/Q9D0R4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ40", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DDX56", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40", "locus": { "chromosome": "4", "start_pos": 76875298, "end_pos": 76865589, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010602", "url": "https://www.ensembl.org/id/ENSBTAG00000010602" } ] } } ], "crossref": [ { "id": "Q3SZ40", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ40", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010602", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010602", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17961", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17961", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18787", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18787", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508728", "url": "https://www.ncbi.nlm.nih.gov/gene/508728", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508728", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508728", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NASEQCV", "url": "https://omabrowser.org/oma/group/NASEQCV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ40", "url": "https://www.orthodb.org/?gene=Q3SZ40", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47959", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47959", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47959:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47959:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00270", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00270", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029501", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZ40", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ40-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDPESLGFEHMGLDHRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRALVLVPTKELARQAQSMIQQLAAYCARDIRVANVSAAEDSASQRAVLMEKPDVVVGTPSRILNHLQQDNLKLRDSMELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELVLHNPVTLKLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPACVLNGELPLRSRCHIISQFNQGFYDCVIATDAEVLGPPVKGKHRGKGPKRDKASDPEAGVARGIDFHHVCAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQSQLGKIEELLSGDSGAPVLLPYQFHMEEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPLHPAVVKPHLGNVPDYLVPPALRGLVHPHKKRKKPLASKKAKKAKTQNPLRSFKHRGEKCRPTAAPS", "length": 546, "header": "sp|Q3SZ40-1|DDX56_BOVIN Isoform 1 of Probable ATP-dependent RNA helicase DDX56 OS=Bos taurus OX=9913 GN=DDX56 PE=2 SV=1 CANONICAL=Q3SZ40-1" }, "isoforms": [ { "isoform_ac": "Q3SZ40-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40/entry#Q3SZ40-1", "sequence": { "sequence": "MEDPESLGFEHMGLDHRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRALVLVPTKELARQAQSMIQQLAAYCARDIRVANVSAAEDSASQRAVLMEKPDVVVGTPSRILNHLQQDNLKLRDSMELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELVLHNPVTLKLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPACVLNGELPLRSRCHIISQFNQGFYDCVIATDAEVLGPPVKGKHRGKGPKRDKASDPEAGVARGIDFHHVCAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQSQLGKIEELLSGDSGAPVLLPYQFHMEEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPLHPAVVKPHLGNVPDYLVPPALRGLVHPHKKRKKPLASKKAKKAKTQNPLRSFKHRGEKCRPTAAPS", "length": 546, "header": "sp|Q3SZ40-1|DDX56_BOVIN Isoform 1 of Probable ATP-dependent RNA helicase DDX56 OS=Bos taurus OX=9913 GN=DDX56 PE=2 SV=1 CANONICAL=Q3SZ40-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 365, "start_aa": "Thr", "end_pos": 365, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr365", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 126, "end_pos": 126, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ40", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ], "site_lbl": "Ser126" }, { "start_pos": 141, "end_pos": 141, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ40", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ], "site_lbl": "Thr141" }, { "start_pos": 531, "end_pos": 531, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ40", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ], "site_lbl": "Ser531" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:508728", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508728", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K0E0-1", "protein_name": "Probable ATP-dependent RNA helicase DDX56", "gene_name": "Ddx56", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEDQEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHKKATGPVMEQAVRGLVLVPTKELARQAQSMIQQLASYCARDVRVANVSAAEDSASQRAVLMEKPDVVVGTPSRILNHLQQKNLKLRDSLELLVVDEADLLFSFGFEDELKSLLCHLPRIYQAFLMSATFNEDVQTLKELVLHNPVTLKLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKALLFVNTLERGYRLRLFLEQFSIPSCVLNGELPLRSRCHIISQFNQGLYDCVIATDAEILGPQVKAKRQGRGSKGDKASDPESGVARGIDFHHVSAVLNFDLPPTAEAYVHRAGRTARANNPGIVLTFVLPTEQSSLGKIEELLSGEGQAPILLPYQFQMEEIESFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPLHPAVVKPHLGNVPDYLVPAALRGLVHPRKKRRKMPFSRKAKKVKTQNPLRDFKHRGKKPKPTAKPS", "length": 546 }, "evidence": [ { "id": "Q3SZ40", "url": "https://omabrowser.org/oma/group/Q3SZ40/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SSH6-1", "protein_name": "Probable ATP-dependent RNA helicase DDX56", "gene_name": "DDX56", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEDPELLGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKAIGPAVEQAVRGLVLVPTKDLARQAQSMIQQLAAYCARDIRVANVSAAEDSASQRAVLMEKPDIVVGTPSRILNHLQQDNLKLRDSLELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELVLHNPVTLKLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPACVLNGELPLRSRCHIISQFNQGLYDCVIATDAEVLGPPVKGKGKQRGKGPKGERASDPEAGVARGIDFHHVCAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQSHLGKIEELLSGENGAPALLPYQFRMEEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPLHPAVVKPHLGNVPDYLVPPALRGLVRPHKKRKKPLSAKKAKKVKTQNPLRSFKHRGEKRRAEPS", "length": 546 }, "evidence": [ { "id": "Q3SZ40", "url": "https://omabrowser.org/oma/group/Q3SZ40/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HMB1-1", "protein_name": "Probable ATP-dependent RNA helicase DDX56", "gene_name": "Ddx56", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEDQEPLGFEHMGLDPRLLQAVADLGWSQPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHKKATGPVMEQAVRGLVLVPTKELARQAQSMMQQLAAYCARDVRVANVSAAEDSASQRAVLMEKPDVVVGTPSRILNHLQQDNLKLRDSLELLVIDEADLLFSFGFEDELKGLLCHLPRIYQAFLMSATFNEDVQALKELVLHNPVTLKLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKALLFVNTLERGYRLRLFLEQFSIPSCVLNGELPLRSRCHIISQFNQGFYDCVIATDAEILGPPVKGKRRGRGSKGDKAADPESGVARGIDFHHVSAVLNFDLPPTPEAYVHRAGRTARANNPGIVLTFVLPTEQSCLAKIEALLSGEGEAILLPYQFRMEEIESFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPLHPAVVKPHLGNVPDYLVPAALRGIVHPRKKRRKLPPCKKVKKVRTQNPLRDFKHRGKKLKPTAKPS", "length": 545 }, "evidence": [ { "id": "Q3SZ40", "url": "https://omabrowser.org/oma/group/Q3SZ40/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q06218-1", "protein_name": "ATP-dependent RNA helicase DBP9", "gene_name": "DBP9", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSYEKKSVEGAYIDDSTTFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQQKRDIIAKAATGSGKTLAYLIPVIETILEYKKTIDNGEENGTLGIILVPTRELAQQVYNVLEKLVLYCSKDIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQTKINSISLNELKFLVVDEVDLVLTFGYQDDLNKIGEYLPLKKNLQTFLMSATLNDDIQALKQKFCRSPAILKFNDEEINKNQNKLLQYYVKVSEFDKFLLCYVIFKLNLIKGKTLIFVNNIDRGYRLKLVMEQFGIKSCILNSELPVNSRQHIVDQFNKNVYQLLIATDDTEYIKEEDDEIEEGHNTENQEEKSLEGEPENDKKPSKKKKVQVKKDKEYGVSRGVDFKNVACVLNFDLPTTAKSYVHRVGRTARGGKTGTAISFVVPLKEFGKHKPSMLQTAKKDERILSRIIKQQSKLGLELQPYKFDQKQVEAFRYRMEDGFRAVTQVAIREARVKELKQELLASEKLKRHFEENPKELQSLRHDKELHPARVQQHLKRVPDYLLPESARGNGTKVKFVPFHNAKKRHSHKKGRVSKPKNGKVDPLKNFK", "length": 594 }, "evidence": [ { "id": "Q3SZ40", "url": "https://omabrowser.org/oma/group/Q3SZ40/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54VF1-1", "protein_name": "Probable ATP-dependent RNA helicase ddx56", "gene_name": "ddx56", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNLNKNNNSVEDSVSSDLIDLECTFESMGLDNRILRALKKMGFQNPSLVQSKSIPLSLQGKDILAKARTGSGKTAAYSIPIIQKVLMAKEKSNIKGVKAVVLVPTRELCEQVKNHFNQVSYYCQQLVSVVQLGNDKTLDEQKGLLRDIPDVIVSTPTRLVQHLENKTIQLQSTLDILVIDEADLVLNYGHQNDINIIKSFLPKVCQCFLMSATLTKEVEELKKLVLHTPAVLKLEEDKAIQTNLSEYSIKCAEVDKFLLVFSLLRLRLMQGKILFFVNDTNNCYKLKLFFERFHIKCAVLNSELPINSRHDIILQFNKGLFDYLIATDESFKSDSNKKEEQELEDNENEDDDDDDDEMTDVKKEDDEENEDEEENDEENEEDEENEEDEEDEENEEDDDEEENEEDDDKKNKNKKINNSKGDKEYGVARGIDFRNVDIVVNFDFPRTIKNYIHRIGRTARGTNKGIALSFVTYHNEELLKKVSKTRGDAGYNLKPFEFKMNAIEGFRYRVEDVLRTIGIRAIKEAKKTELKQELLNNEKLKSHFSENPQDLLALKHDTTLIKKQVPLHLRVVPEYLLPTQFKNHADQKLEIIPSRPQSGHHGTTGRSLGVNKKLEQKKRKKDILKTLSIKKNTTLTGEELAQARSKSLIKRLKIKEGNISADGSYKTVKVQKKGANNNRRKLIVD", "length": 685 }, "evidence": [ { "id": "Q3SZ40", "url": "https://omabrowser.org/oma/group/Q3SZ40/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9D0R4-1", "protein_name": "Probable ATP-dependent RNA helicase DDX56", "gene_name": "Ddx56", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEDQEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQSLLHKKATGPVMEQAVRGLVLVPTKELARQAQAMIQQLAAYCARDVRVANVSAAEDSASQRAVLMEKPDVVVGTPSRVLSHLQQNTLKLRDSLELLVVDEADLLFSFGFEDELKSLLCHLPRIYQAFLMSATFNEDVQTLKELVLHNPVTLKLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKALLFVNTLERGYRLRLFLEQFSIPSCVLNGELPLRSRCHIISQFNQGLYDCVIATDAEILGPQVKGKRRGRGSKGNKASDPESGVARGIDFHHVSAVLNFDLPPTAEAYVHRAGRTARANNPGIVLTFVLPAEQPFLGKIEDLLSGEGEAPILLPYQFQMEEIESFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPLHPAVVKPHLGHVPDYLVPAALRGLVHPRKKRRKVPFSRKAKKVKAQNPLRDFKHRGKKPKPAAKPS", "length": 546 }, "evidence": [ { "id": "Q3SZ40", "url": "https://omabrowser.org/oma/group/Q3SZ40/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NY93-1", "protein_name": "Probable ATP-dependent RNA helicase DDX56", "gene_name": "DDX56", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEDSEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRGLVLVPTKELARQAQSMIQQLATYCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAEVLGAPVKGKRRGRGPKGDKASDPEAGVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIEELLSGENRGPILLPYQFRMEEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPLHPAVVKPHLGHVPDYLVPPALRGLVRPHKKRKKLSSSCRKAKRAKSQNPLRSFKHKGKKFRPTAKPS", "length": 547 }, "evidence": [ { "id": "Q3SZ40", "url": "https://omabrowser.org/oma/group/Q3SZ40/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9SW44-1", "protein_name": "DEAD-box ATP-dependent RNA helicase 16", "gene_name": "RH16", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGKTKLKPVEDVNSEVVDEVEKAEEVEEQRNDREQEEEQKEEEAPKSFEELGLDSRLIRALTKKGIEKPTLIQQSAIPYILEGKDVVARAKTGSGKTLAYLLPLLQKLFSADSVSKKKLAPSAFILVPSRELCQQVYTEVSSLIELCRVQLKAVQLTSSMSASDMRNALAGLPEILVSTPACIPKCFAAGVLEPTAVSESLSILVLDEADLLLSYGYEDNLRSVTSIIPRRCQCLLMSATTSSDVEKLKKLILHNPIVLTLTEDNDKEEAVPSNVQQFWISCSAQDKLLHILALLKLEVVQKKILIFINTIDMGFRLKLFLEKFGIKSAILNGELPQNSRLHILEQFNAGLFDYLIATDDNSQTKKQKEEAKGEANKENKKNNKRSKPKLDAEFGVVRGIDFKKVHTVINFDMPQSVTGYIHRIGRTGRAYSSGSSVSLISPDEMEGFEDIKSFLASDKNKDIDIITPFPLLTENAVESLRYRAEDVAKSVTKIAVRESRAQDLRNEIINSEKLKAHFEANPRDLDLLRHDKPLSKTAPAPHLKDIPEYLVDAKTQEASKMVKLARAAMGNTRRSGGGGGRNNKNKKRSRKGSDPLKTFNPNGSKRGAVGQKDGKDSSSTKKQKTV", "length": 626 }, "evidence": [ { "id": "Q3SZ40", "url": "https://omabrowser.org/oma/group/Q3SZ40/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VRI0-1", "protein_name": "Probable ATP-dependent RNA helicase DDX56", "gene_name": "Ddx56", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSQMTQKTVQFHELELDQRILKAVAQLGWQQPTLIQSTAIPLLLEGKDVVVRARTGSGKTATYALPLIQKILNSKLNASEQYVSAVVLAPTKELCRQSRKVIEQLVESCGKVVRVADIADSSNDTVTQRHALSESPDIVVATPANLLAYAEAGSVVDLKHVETLVVDEADLVFAYGYEKDFKRLIKHLPPIYQAVLVSATLTDDVVRMKGLCLNNPVTLKLEEPELVPQDQLSHQRILAEENDKPAILYALLKLRLIRGKSIIFVNSIDRCYKVRLFLEQFGIRACVLNSELPANIRIHTISQFNKGTYDIIIASDEHHMEKPGGKSATNRKSPRSGDMESSASRGIDFQCVNNVINFDFPRDVTSYIHRAGRTARGNNKGSVLSFVSMKESKVNDSVEKKLCDSFAAQEGEQIIKNYQFKMEEVESFRYRAQDCWRAATRVAVHDTRIREIKIEILNCEKLKAFFEENKRDLQALRHDKPLRAIKVQSHLSDMPEYIVPKALKRVVGTSSSPVGASEAKQPRQSAAKAAFERQVNDPLMASQVDFGKRRPAHRRKKKAL", "length": 560 }, "evidence": [ { "id": "Q3SZ40", "url": "https://omabrowser.org/oma/group/Q3SZ40/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ40", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ40", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ40", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ40", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ40", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ40", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { 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} ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": 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"https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": 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"https://www.uniprot.org/uniprotkb/Q59HJ6" } ] } ] }, { "uniprot_ac": "Q5E9B5", "gene_name": "ACTG2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q5E9B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B5" } ] } ] }, { "uniprot_ac": "Q5E9H5", "gene_name": "BCS1L", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ] } ] }, { "uniprot_ac": "Q5E9M9", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5E9M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ] } ] }, { "uniprot_ac": "Q5E9N5", "gene_name": "CLPB", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q5E9N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9N5" } ] } ] }, { "uniprot_ac": "Q5W5U4", "gene_name": "DDX4", "activity": 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"uniprot_ac": "Q9TTA5", "gene_name": "SMARCAL1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "Q9TTA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTA5" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ40-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 546, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ40-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ40" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" }, { "id": "PRU00541", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00541" } ], "ann_type": "Domain_Extent_Annotation", 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"homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 365 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 126, 141, 531 ], "sequon_annotation_sites": [ { "start_pos": 117, "end_pos": 119 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ52-1", "uniprot_ac": "Q3SZ52", "uniprot_id": "UB2V1_BOVIN", "mass": { "chemical_mass": 16495.0, "monoisotopic_mass": 16495.0 }, "refseq": { "ac": "NP_001030574", "name": "ubiquitin-conjugating enzyme E2 variant 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030574" }, "gene_names": [ { "name": "UBE2V1", "type": "recommended", "evidence": [ { "id": "Q3SZ52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ52" } ] }, { "name": "UBE2V1", "type": "synonym", "evidence": [ { "id": "NP_001030574", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030574" } ] } ], "protein_names": [ { "name": "Ubiquitin-conjugating enzyme E2 variant 1", "type": "recommended", "evidence": [ { "id": "Q3SZ52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ52/entry#names_and_taxonomy" } ] }, { "name": "UEV-1", "type": "synonym", "evidence": [ { "id": "NP_001030574", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030574" }, { "id": "Q3SZ52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ52/entry#names_and_taxonomy" } ] }, { "name": "ubiquitin-conjugating enzyme E2 variant 1", "type": "synonym", "evidence": [ { "id": "NP_001030574", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030574" } ] } ], "function": [ { "annotation": "Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity). Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes (By similarity). Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (By similarity). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ52", "url": "https://www.uniprot.org/uniprotkb/Q3SZ52#function" }, { "database": "UniProtKB", "id": "Q13404", "url": "https://www.uniprot.org/uniprotkb/Q13404#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ52", "url": "https://www.uniprot.org/uniprotkb/Q3SZ52" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBE2V1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ52", "locus": { "chromosome": "13", "start_pos": 78115183, "end_pos": 78144957, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027316", "url": "https://www.ensembl.org/id/ENSBTAG00000027316" } ] } } ], "crossref": [ { "id": "Q3SZ52", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ52", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd23807", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23807", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617771", "url": "https://www.ncbi.nlm.nih.gov/gene/617771", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000608", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000608", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617771", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617771", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZ52", "url": "https://www.orthodb.org/?gene=Q3SZ52", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24068", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24068", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00179", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00179", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030574", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZ52", "url": "https://www.uniprot.org/uniprotkb/Q3SZ52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ52-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ52-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAATTGSGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPFVRFVTKINMNGVNSSNGVVDPRAISVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQCYSN", "length": 147, "header": "sp|Q3SZ52-1|UB2V1_BOVIN Isoform 1 of Ubiquitin-conjugating enzyme E2 variant 1 OS=Bos taurus OX=9913 GN=UBE2V1 PE=2 SV=1 CANONICAL=Q3SZ52-1" }, "isoforms": [ { "isoform_ac": "Q3SZ52-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ52/entry#Q3SZ52-1", "sequence": { "sequence": "MAATTGSGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPFVRFVTKINMNGVNSSNGVVDPRAISVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQCYSN", "length": 147, "header": "sp|Q3SZ52-1|UB2V1_BOVIN Isoform 1 of Ubiquitin-conjugating enzyme E2 variant 1 OS=Bos taurus OX=9913 GN=UBE2V1 PE=2 SV=1 CANONICAL=Q3SZ52-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617771", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617771", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "ubiquitin conjugating enzyme complex", "id": "GO:0031371", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031371", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ52", "url": "https://www.uniprot.org/uniprotkb/Q3SZ52" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ52", "url": "https://www.uniprot.org/uniprotkb/Q3SZ52" } ], "pmid": "" }, { "name": "ubiquitin ligase complex", "id": "GO:0000151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000151", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ52", "url": "https://www.uniprot.org/uniprotkb/Q3SZ52" } ], "pmid": "" }, { "name": "UBC13-MMS2 complex", "id": "GO:0031372", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031372", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ52", "url": "https://www.uniprot.org/uniprotkb/Q3SZ52" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein K63-linked ubiquitination", "id": "GO:0070534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070534", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ52", "url": "https://www.uniprot.org/uniprotkb/Q3SZ52" } ], "pmid": "" }, { "name": "DNA damage tolerance", "id": "GO:0006301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006301", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ52", "url": "https://www.uniprot.org/uniprotkb/Q3SZ52" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ52-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 147, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ52-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ52" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SZ52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ52" }, { "id": "PRU00388", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00388" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBC core", "eco_id": "ECO_0000255", "start_pos": 12, "end_pos": 147, "start_aa": "Pro", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 94, "end_pos": 96 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ55-1", "uniprot_ac": "Q3SZ55", "uniprot_id": "PTCD2_BOVIN", "mass": { "chemical_mass": 43945.0, "monoisotopic_mass": 43945.0 }, "refseq": { "ac": "NP_001030375", "name": "pentatricopeptide repeat-containing protein 2, mitochondrial", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030375" }, "gene_names": [ { "name": "PTCD2", "type": "recommended", "evidence": [ { "id": "Q3SZ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ55" } ] }, { "name": "PTCD2", "type": "synonym", "evidence": [ { "id": "NP_001030375", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030375" } ] } ], "protein_names": [ { "name": "Pentatricopeptide repeat-containing protein 2, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q3SZ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ55/entry#names_and_taxonomy" } ] }, { "name": "pentatricopeptide repeat-containing protein 2, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001030375", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030375" } ] } ], "function": [ { "annotation": "Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ55", "url": "https://www.uniprot.org/uniprotkb/Q3SZ55#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ55", "url": "https://www.uniprot.org/uniprotkb/Q3SZ55" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTCD2", "url": "https://www.uniprot.org/uniprotkb/Q3SZ55", "locus": { "chromosome": "20", "start_pos": 9254758, "end_pos": 9286706, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014675", "url": "https://www.ensembl.org/id/ENSBTAG00000014675" } ] } } ], "crossref": [ { "id": "Q3SZ55", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ55", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014675", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014675", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514705", "url": "https://www.ncbi.nlm.nih.gov/gene/514705", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002885", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002885", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034629", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034629", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034913", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034913", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514705", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514705", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KFYCSQI", "url": "https://omabrowser.org/oma/group/KFYCSQI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ55", "url": "https://www.orthodb.org/?gene=Q3SZ55", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14700", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14700", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14700:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14700:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10037", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10037", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030375", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZ55", "url": "https://www.uniprot.org/uniprotkb/Q3SZ55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ55-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ55-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAATLRPPKQVLLLHALRSLVYHWVGGSGSTCCLCPLGAKRYLLTDSIVKLKEFQRKKVAVACNLPGTKETYLRNLEEKLTQNKLILKEELRTLLHLCTSRDDVELAKHVIYRYHAENRNITLGEYKFGPLFVRLCYELDLEDSAVELIKDQHLQGFFSDSTSFNILMDMLFIKGKYRSALEVLIQMKNQDLKFNKDTYVLAFAICYKLNSPESFQICTTLREEALIKGEILPRRASCFAVALALNQNQVAKAISIFSQIMNPESIICTNLNIMIHIQSNMLKTLIDILKDATEGNLSRFVKRHVFSEEVLVKVREKVKDVPALLAEFDELNKKLHRSGQVTAYTLDALLCHTPSDRQSYTVLLNKRTVSRRTFQPLSQSLWAE", "length": 384, "header": "sp|Q3SZ55-1|PTCD2_BOVIN Isoform 1 of Pentatricopeptide repeat-containing protein 2, mitochondrial OS=Bos taurus OX=9913 GN=PTCD2 PE=2 SV=1 CANONICAL=Q3SZ55-1" }, "isoforms": [ { "isoform_ac": "Q3SZ55-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ55/entry#Q3SZ55-1", "sequence": { "sequence": "MAATLRPPKQVLLLHALRSLVYHWVGGSGSTCCLCPLGAKRYLLTDSIVKLKEFQRKKVAVACNLPGTKETYLRNLEEKLTQNKLILKEELRTLLHLCTSRDDVELAKHVIYRYHAENRNITLGEYKFGPLFVRLCYELDLEDSAVELIKDQHLQGFFSDSTSFNILMDMLFIKGKYRSALEVLIQMKNQDLKFNKDTYVLAFAICYKLNSPESFQICTTLREEALIKGEILPRRASCFAVALALNQNQVAKAISIFSQIMNPESIICTNLNIMIHIQSNMLKTLIDILKDATEGNLSRFVKRHVFSEEVLVKVREKVKDVPALLAEFDELNKKLHRSGQVTAYTLDALLCHTPSDRQSYTVLLNKRTVSRRTFQPLSQSLWAE", "length": 384, "header": "sp|Q3SZ55-1|PTCD2_BOVIN Isoform 1 of Pentatricopeptide repeat-containing protein 2, mitochondrial OS=Bos taurus OX=9913 GN=PTCD2 PE=2 SV=1 CANONICAL=Q3SZ55-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 378, "end_pos": 378, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ55", "url": "https://www.uniprot.org/uniprotkb/Q3SZ55" } ], "site_lbl": "Ser378" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514705", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514705", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZPV5-1", "protein_name": "Pentatricopeptide repeat-containing protein 2, mitochondrial", "gene_name": "Ptcd2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATVFRPLEHLRVPHRSLHPGVTGSGSACCRCTLGAKRYLLTDNIVKLKEFQHKKMVIAYNLPGTKEIYFRNMEEKLTQNKLILREELKTLLHLCQSSEDVRLAKAVIYRYHTENRNFTLGEYKFGPVFMRLCYELDLEDSAMELIRDKHLQGFFVDSTSFNILMNMLFTKGKYESALQVLIEMKNQDVKFSKDTYVLAFAICYKLNSPESLKICTTLREEALMKGDVISRRASCFAVALALNQNQLEKATSIFSQIMNPESITCTNLNRTWFLTFPAGTCQILIHIQSNMLESLLKILQDALDPNLSKFVRRHTFSEEVLAKTREKLKGRPTLIARFDEVYGKLHINGQITIYTLDALLCHVPRDKRSNTLLLKKRTVSHRTLQPLSRSLLTE", "length": 394 }, "evidence": [ { "id": "Q3SZ55", "url": "https://omabrowser.org/oma/group/Q3SZ55/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q566X6-1", "protein_name": "Pentatricopeptide repeat-containing protein 2, mitochondrial", "gene_name": "ptcd2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MALQALNIWTRVILTDASRAAVFRGALQSHCFKCRHGAKRFLLSEDVVKLEEFQQKKLSHEMSQLKDYRFDIVNQKLEKNEIILKTELKTLLHSCQSAEDVIVARNVIKRYHENNRTTAFGEFKFGPLFMRLCYELGLEELAATTIKDPALKGFFSDTTSFNITIDMLFNKQLYESGLEVVGEMKKQGVSLSRDTFMLVFAICYKLNTSRSYHICLTLLEEGQTKGNIIPRRAYCFAIALALKQNDLERAQIFYSHIMSTGTRLCQNLRVFILAVKGSMKEAVYVLKTARISETPVLVRKPEFSREVVNVLRRKSAGGVWEERVEQVLTQLEKAGQITEITLDDLLCYTPSRKRRLLELPQKDRQIKQRTRKSLQSGLLLE", "length": 381 }, "evidence": [ { "id": "Q3SZ55", "url": "https://omabrowser.org/oma/group/Q3SZ55/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8R3K3-1", "protein_name": "Pentatricopeptide repeat-containing protein 2, mitochondrial", "gene_name": "Ptcd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATVFRPLERLRVPRPSLHPGVTGSGSACCRCTLGAKRYLLTDNIVKLKEFQHKKIAIAYNLPGTKEIYFRNLEEKLTQNKLILKEELKTLLYLCQSLEDVQLAKAVIYRYHAENKNFTLGEYKFGPVFMRLCYELDLEDSAVELVRDKHLQGFFLDSTSFNILMDMLFTKGKYERALQVLIEMKNQDVRFSKETYILAFAICYKLNTLESLKICTTLREEALIKGDIICRRAYCFVVALALNKNQLKNAVSIFSQIVNPESIVCINLNILIHIQSNMLESLLKILEDSLDTNLSKFVRRHTFSEEVLAKVREKLKDSPALIARFDEVYGKLHVNGQITVHSLDALLCHVPRDKRSNLLLLKKRAVSHRTLQPLSRSLLTE", "length": 381 }, "evidence": [ { "id": "Q3SZ55", "url": "https://omabrowser.org/oma/group/Q3SZ55/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WV60-1", "protein_name": "Pentatricopeptide repeat-containing protein 2, mitochondrial", "gene_name": "PTCD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVRDSMAAAFRPSNRVLLQALQILVYPGVGGSGSVSCRCPLGAKRYLLTDNVVKLKEFQQKKVAVACNLSGTKETYFRNLKKKLTQNKLILKGELITLLHLCESRDHVELAKNVIYRYHAENKNFTLGEYKFGPLFVRLCYELDLEESAVELMKDQHLRGFFSDSTSFNILMDMLFIKGKYKSALQVLIEMKNQDVKFTKDTYVLAFAICYKLNSPESFKICTTLREEALLKGEILSRRASCFAVALALNQNEMAKAVSIFSQIMNPESIACINLNIIIHIQSNMLENLIKTLKNAAEGNLSKFVKRHVFSEEVLAKVREKVKDVPALVAKFDEIYGTLHITGQVTTDSLDAVLCHTPRDRKSHTLLLNKRMVSRRTFQPLSQSLLAE", "length": 388 }, "evidence": [ { "id": "Q3SZ55", "url": "https://omabrowser.org/oma/group/Q3SZ55/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ55", "url": "https://www.uniprot.org/uniprotkb/Q3SZ55" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ55", "url": "https://www.uniprot.org/uniprotkb/Q3SZ55" } ], "pmid": "" }, { "name": "mitochondrion organization", "id": "GO:0007005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007005", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ55", "url": "https://www.uniprot.org/uniprotkb/Q3SZ55" } ], "pmid": "" }, { "name": "regulation of mRNA processing", "id": "GO:0050684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050684", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ55", "url": "https://www.uniprot.org/uniprotkb/Q3SZ55" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" }, { "start_pos": 296, "end_pos": 298, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ55-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 384, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ55-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ55" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 378 ], "sequon_annotation_sites": [ { "start_pos": 120, "end_pos": 122 }, { "start_pos": 296, "end_pos": 298 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ62-1", "uniprot_ac": "Q3SZ62", "uniprot_id": "PGAM1_BOVIN", "mass": { "chemical_mass": 28852.0, "monoisotopic_mass": 28852.0 }, "refseq": { "ac": "NP_001029226", "name": "phosphoglycerate mutase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029226" }, "gene_names": [ { "name": "PGAM1", "type": "recommended", "evidence": [ { "id": "Q3SZ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ] }, { "name": "PGAM1", "type": "synonym", "evidence": [ { "id": "NP_001029226", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029226" } ] }, { "name": "PGAM4", "type": "synonym", "evidence": [ { "id": "NP_001029226", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029226" } ] } ], "protein_names": [ { "name": "Phosphoglycerate mutase 1", "type": "recommended", "evidence": [ { "id": "Q3SZ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62/entry#names_and_taxonomy" } ] }, { "name": "5.4.2.11", "type": "synonym", "evidence": [ { "id": "Q3SZ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62/entry#names_and_taxonomy" } ] }, { "name": "5.4.2.4", "type": "synonym", "evidence": [ { "id": "Q3SZ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62/entry#names_and_taxonomy" } ] }, { "name": "BPG-dependent PGAM 1", "type": "synonym", "evidence": [ { "id": "NP_001029226", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029226" }, { "id": "Q3SZ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62/entry#names_and_taxonomy" } ] }, { "name": "PGAM-B", "type": "synonym", "evidence": [ { "id": "NP_001029226", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029226" }, { "id": "Q3SZ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62/entry#names_and_taxonomy" } ] }, { "name": "Phosphoglycerate mutase isozyme B", "type": "synonym", "evidence": [ { "id": "Q3SZ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62/entry#names_and_taxonomy" } ] }, { "name": "phosphoglycerate mutase 1 (brain)", "type": "synonym", "evidence": [ { "id": "NP_001029226", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029226" } ] }, { "name": "phosphoglycerate mutase 1", "type": "synonym", "evidence": [ { "id": "NP_001029226", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029226" } ] }, { "name": "phosphoglycerate mutase 4", "type": "synonym", "evidence": [ { "id": "NP_001029226", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029226" } ] }, { "name": "phosphoglycerate mutase isozyme B", "type": "synonym", "evidence": [ { "id": "NP_001029226", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029226" } ] } ], "function": [ { "annotation": "Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate, a crucial step in glycolysis, by using 2,3-bisphosphoglycerate. Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ62", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62#function" }, { "database": "UniProtKB", "id": "P18669", "url": "https://www.uniprot.org/uniprotkb/P18669#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ62", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PGAM1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62", "locus": { "chromosome": "26", "start_pos": 18655665, "end_pos": 18649155, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012697", "url": "https://www.ensembl.org/id/ENSBTAG00000012697" } ] } } ], "crossref": [ { "id": "Q3SZ62", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ62", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012697", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012697", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07067", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07067", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "404148", "url": "https://www.ncbi.nlm.nih.gov/gene/404148", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q3SZ62", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q3SZ62*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001345", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001345", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013078", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013078", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029033", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029033", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:404148", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404148", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MLPYWYD", "url": "https://omabrowser.org/oma/group/MLPYWYD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ62", "url": "https://www.orthodb.org/?gene=Q3SZ62", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11931", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11931", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00300", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00300", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-70171", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70171", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70263", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029226", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "15901", "url": "https://www.rhea-db.org/rhea/15901", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "17765", "url": "https://www.rhea-db.org/rhea/17765", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZ62", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ62-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAYKLVLIRHGESTWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEEAIMELNLPTGIPMVYELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGKAKK", "length": 254, "header": "sp|Q3SZ62-1|PGAM1_BOVIN Isoform 1 of Phosphoglycerate mutase 1 OS=Bos taurus OX=9913 GN=PGAM1 PE=2 SV=3 CANONICAL=Q3SZ62-1" }, "isoforms": [ { "isoform_ac": "Q3SZ62-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62/entry#Q3SZ62-1", "sequence": { "sequence": "MAAYKLVLIRHGESTWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEEAIMELNLPTGIPMVYELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGKAKK", "length": 254, "header": "sp|Q3SZ62-1|PGAM1_BOVIN Isoform 1 of Phosphoglycerate mutase 1 OS=Bos taurus OX=9913 GN=PGAM1 PE=2 SV=3 CANONICAL=Q3SZ62-1" }, "locus": { "chromosome": "26", "start_pos": 18654749, "end_pos": 18649183, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032937.5", "url": "https://www.ensembl.org/id/ENSBTAT00000032937.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032864.2", "url": "https://www.ensembl.org/id/ENSBTAP00000032864.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 118, "end_pos": 118, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ62", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ], "site_lbl": "Ser118" }, { "start_pos": 14, "end_pos": 14, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ62", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ], "site_lbl": "Ser14" }, { "start_pos": 23, "end_pos": 23, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ62", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ], "site_lbl": "Ser23" }, { "start_pos": 26, "end_pos": 26, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ62", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ], "site_lbl": "Tyr26" }, { "start_pos": 31, "end_pos": 31, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ62", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ], "site_lbl": "Ser31" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:404148", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404148", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-BTA-70171", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70171", "resource": "Reactome", "description": "Glycolysis" }, { "id": "R-BTA-70263", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70263", "resource": "Reactome", "description": "Gluconeogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AJQ2-1", "protein_name": "Phosphoglycerate mutase", "gene_name": "PGAM1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGKAKK", "length": 254 }, "evidence": [ { "id": "Q3SZ62", "url": "https://omabrowser.org/oma/group/Q3SZ62/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P00950-1", "protein_name": "Phosphoglycerate mutase 1", "gene_name": "GPM1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MPKLVLVRHGQSEWNEKNLFTGWVDVKLSAKGQQEAARAGELLKEKKVYPDVLYTSKLSRAIQTANIALEKADRLWIPVNRSWRLNERHYGDLQGKDKAETLKKFGEEKFNTYRRSFDVPPPPIDASSPFSQKGDERYKYVDPNVLPETESLALVIDRLLPYWQDVIAKDLLSGKTVMIAAHGNSLRGLVKHLEGISDADIAKLNIPTGIPLVFELDENLKPSKPSYYLDPEAAAAGAAAVANQGKK", "length": 247 }, "evidence": [ { "id": "Q3SZ62", "url": "https://omabrowser.org/oma/group/Q3SZ62/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P18669-1", "protein_name": "Phosphoglycerate mutase 1", "gene_name": "PGAM1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGKAKK", "length": 254 }, "evidence": [ { "id": "Q3SZ62", "url": "https://omabrowser.org/oma/group/Q3SZ62/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P25113-1", "protein_name": "Phosphoglycerate mutase 1", "gene_name": "Pgam1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGKVKK", "length": 254 }, "evidence": [ { "id": "Q3SZ62", "url": "https://omabrowser.org/oma/group/Q3SZ62/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q54NE6-1", "protein_name": "Probable phosphoglycerate mutase", "gene_name": "gpmA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MVYKLVLIRHGESTWNKENKFTGWTDVDLSEKGVQEAHEAGKRLLKAGFTFDIAYTSVLKRAIRTLWILLEELNLYWIPVSRQWRLNERMYGSLQGLNKSETAAKYGEDQVLIWRRSYDIPPPALEESDERYPGNDPRYAKLDKSDLPKTECLKDTVERFLPLWNDTIAPTIKSGQKVLIAAHGNSIRALVKYLDNIADDKIVSMDIPTGIPLVYELDENLKPIKHYYLADESELNAAIQAVANQGKAK", "length": 249 }, "evidence": [ { "id": "Q3SZ62", "url": "https://omabrowser.org/oma/group/Q3SZ62/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5ZLN1-1", "protein_name": "Phosphoglycerate mutase 1", "gene_name": "PGAM1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAYRLVLVRHGESAWNLENRFCGWYDADLSPAGQQEARRGGEALRDAGYEFDICFTSVQKRAIRTLWNVLDAIDQMWLPVVRTWRLNERHYGALTGLNKAETAAKHGEAQVKIWRRSFDIPPPPMQSDHPFFSTISKDRRYADLTEDQLPTCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGMSEEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGKVKK", "length": 254 }, "evidence": [ { "id": "Q3SZ62", "url": "https://omabrowser.org/oma/group/Q3SZ62/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9DBJ1-1", "protein_name": "Phosphoglycerate mutase 1", "gene_name": "Pgam1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGKVKK", "length": 254 }, "evidence": [ { "id": "Q3SZ62", "url": "https://omabrowser.org/oma/group/Q3SZ62/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9LM13-1", "protein_name": "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1", "gene_name": "gpmA1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MATATSHQSVVSFASLRSSPSSTISQCGFKIDSSLSFTSKKTNFCKIKAMASSVSYDNTLLSPSKTIPDNSQKKSNEAALILIRHGESLWNEKNLFTGCVDVPLTEKGVEEAIEAGKRISNIPVDVIFTSSLIRAQMTAMLAMIQHRRKKVPIILHDESEQAKTWSQVFSDETKNQSIPVIPAWQLNERMYGELQGLNKQETAERYGKEQVHEWRRSYDIPPPKGESLEMCAERAVAYFQDNIEPKLAAGKNVMIAAHGNSLRSIIMYLDKLTCQEVISLELSTGIPLLYIFKEGKFMKRGSPVGPTEAGVYAYTKRLAQYRQKLEDDSEVLCA", "length": 334 }, "evidence": [ { "id": "Q3SZ62", "url": "https://omabrowser.org/oma/group/Q3SZ62/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VAN7-1", "protein_name": "Phosphoglycerate mutase", "gene_name": "Pgam1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGGKYKIVMVRHGESEWNQKNQFCGWYDANLSEKGQEEALAAGKAVKDAGLEFDVAHTSVLTRAQVTLASILKASGHKEIPIQKTWRLNERHYGGLTGLNKAETAAKYGEAQVQIWRRSFDTPPPPMEPGHPYYENIVKDPRYAEGPKPEEFPQFESLKLTIERTLPYWNDVIIPQMKEGKRILIAAHGNSLRGIVKHLDNLSEDAIMALNLPTGIPFVYELDENFKPVVSMQFLGDEETVKKAIEAVAAQGKAK", "length": 255 }, "evidence": [ { "id": "Q3SZ62", "url": "https://omabrowser.org/oma/group/Q3SZ62/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "bisphosphoglycerate mutase activity", "id": "GO:0004082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004082", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ62", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ], "pmid": "" }, { "name": "phosphoglycerate mutase activity", "id": "GO:0004619", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004619", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ62", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ62", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ62", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ62", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "gluconeogenesis", "id": "GO:0006094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006094", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ62", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ], "pmid": "" }, { "name": "canonical glycolysis", "id": "GO:0061621", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061621", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ62", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15901", "name": "", "equation": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MX69-1", "Q3T014-1", "E1B959-1", "F1N2F2-1", "Q32KV0-1", "Q3SZ62-1", "A0A3Q1NEF2-1" ], "evidence": [ { "id": "15901", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15901" } ] }, { "id": "17765", "name": "", "equation": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MX69-1", "Q3T014-1", "E1B959-1", "F1N2F2-1", "Q32KV0-1", "Q3SZ62-1", "A0A3Q1NEF2-1" ], "evidence": [ { "id": "17765", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17765" } ] }, { "id": "R-BTA-6798748", "name": "Exocytosis of secretory granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, secretory granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P19120-1", "P68401-1", "A0JNA3-1", "F1MMD5-1", "A0AAA9S4U4-1", "P80177-1", "Q0II59-1", "Q0VCM4-1", "Q3SWY3-1", "Q3SYU2-1", "F1MHT1-1", "A0AAA9RV00-1", "A0ABI0P3F2-1", "P62935-1", "P68103-1", "Q3T0Q4-1", "A0A452DJA8-1", "E1BNY9-1", "A0A3Q1LMV5-1", "A0A3Q1LTT9-1", "A1A4J1-1", "F1MQ78-1", "G3X757-1", "P00432-1", "Q76LV2-1", "A0A140T8A5-1", "A0A3Q1LR63-1", "Q56JW4-1", "Q3T0A3-1", "Q3ZBD7-1", "Q58DK5-1", "Q3SZ62-1", "Q3T0V9-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6798748", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798748" } ] }, { "id": "R-BTA-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, ficolin-1-rich granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P19120-1", "P68401-1", "P80227-1", "A0JNA3-1", "F1MMD5-1", "Q32PF2-1", "Q3SZH7-1", "A0AAA9S4U4-1", "A0AAA9S9V5-1", "P07688-1", "O46414-1", "P25326-1", "P80177-1", "Q0VCM4-1", "Q3SWY3-1", "Q3SYU2-1", "F1MHT1-1", "F1MMR6-1", "A0ABI0NJH4-1", "A0AAA9RV00-1", "A0ABI0P3F2-1", "P05689-1", "P46196-1", "P52176-1", "P62935-1", "P68103-1", "Q17QB3-1", "Q3T0Q4-1", "Q27970-1", "A0A452DJA8-1", "E1BNY9-1", "A0A3Q1LMV5-1", "A0A3Q1LTT9-1", "A0AAA9SYX5-1", "A1A4J1-1", "E1BB52-1", "F1MQ78-1", "G3X757-1", "P00432-1", "Q76LV2-1", "A0A140T8A5-1", "A0A3Q1LR63-1", "A0A3Q1NDQ7-1", "Q3T0A3-1", "Q3ZBD7-1", "Q58DK5-1", "Q3SZ62-1", "Q3T0V9-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6800434", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6800434" } ] }, { "id": "R-BTA-71445", "name": "PGAM dimers isomerise 2PG to 3PG", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N2F2-1", "Q3SZ62-1" ], "evidence": [ { "id": "R-BTA-71445", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71445" } ] }, { "id": "R-BTA-71654", "name": "PGAM dimers isomerise 3PG to 2PG", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N2F2-1", "Q3SZ62-1" ], "evidence": [ { "id": "R-BTA-71654", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71654" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T8A5", "gene_name": "IDH1", "activity": [ { "ec_number": "1.1.1.42", "activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] }, { "ec_number": "1.1.1.42", "activity": "", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] } ] }, { "uniprot_ac": "A0A3Q1LMV5", "gene_name": "LOC281806", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] } ] }, { "uniprot_ac": "A0A3Q1LR63", "gene_name": "HK3", "activity": [ { "ec_number": "2.7.1.1", "activity": "D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR63" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR63" } ] } ] }, { "uniprot_ac": "A0A3Q1LTT9", "gene_name": "MAPK14", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LTT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT9" } ] } ] }, { "uniprot_ac": "A0A3Q1NDQ7", "gene_name": "GLB1", "activity": [ { "ec_number": "3.2.1.23", "activity": "Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.", "evidence": [ { "id": "A0A3Q1NDQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDQ7" } ] }, { "ec_number": "3.2.1.23", "activity": "", "evidence": [ { "id": "A0A3Q1NDQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDQ7" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF2", "gene_name": "LOC112447087", "activity": [ { "ec_number": "5.4.2.11", "activity": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.", "evidence": [ { "id": "A0A3Q1NEF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF2" } ] }, { "ec_number": "5.4.2.4", "activity": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+).", "evidence": [ { "id": "A0A3Q1NEF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF2" } ] }, { "ec_number": "5.4.2.11", "activity": "", "evidence": [ { "id": "A0A3Q1NEF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF2" } ] }, { "ec_number": "5.4.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1NEF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF2" } ] } ] }, { "uniprot_ac": "A0A452DJA8", "gene_name": "PNP", "activity": [ { "ec_number": "2.4.2.1", "activity": "adenosine + phosphate = alpha-D-ribose 1-phosphate + adenine.", "evidence": [ { "id": "A0A452DJA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DJA8" } ] }, { "ec_number": "2.4.2.1", "activity": "", "evidence": [ { "id": "A0A452DJA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DJA8" } ] } ] }, { "uniprot_ac": "A0AAA9RV00", "gene_name": "PPIE", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0AAA9RV00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV00" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0AAA9RV00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV00" } ] } ] }, { "uniprot_ac": "A0AAA9S4U4", "gene_name": "ALDOC", "activity": [ { "ec_number": "4.1.2.13", "activity": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate.", "evidence": [ { "id": "A0AAA9S4U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4U4" } ] }, { "ec_number": "4.1.2.13", "activity": "", "evidence": [ { "id": "A0AAA9S4U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4U4" } ] } ] }, { "uniprot_ac": "A0AAA9S9V5", "gene_name": "CANT1", "activity": [ { "ec_number": "3.6.1.6", "activity": "a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ] }, { "ec_number": "3.6.1.6", "activity": "", "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ] } ] }, { "uniprot_ac": "A0AAA9SYX5", "gene_name": "KCMF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9SYX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYX5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9SYX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYX5" } ] } ] }, { "uniprot_ac": "A0ABI0NJH4", "gene_name": "GNS", "activity": [ { "ec_number": "3.1.6.14", "activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.", "evidence": [ { "id": "A0ABI0NJH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJH4" } ] }, { "ec_number": "3.1.6.14", "activity": "", "evidence": [ { "id": "A0ABI0NJH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJH4" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0JNA3", "gene_name": "IMPDH1", "activity": [ { "ec_number": "1.1.1.205", "activity": "IMP + NAD(+) + H2O = XMP + NADH + H(+).", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] } ] }, { "uniprot_ac": "A1A4J1", "gene_name": "PFKL", "activity": [ { "ec_number": "2.7.1.11", "activity": "beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+).", "evidence": [ { "id": "A1A4J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4J1" } ] }, { "ec_number": "2.7.1.11", "activity": "", "evidence": [ { "id": "A1A4J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4J1" } ] } ] }, { "uniprot_ac": "E1B959", "gene_name": "", "activity": [ { "ec_number": "5.4.2.11", "activity": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.", "evidence": [ { "id": "E1B959", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B959" } ] }, { "ec_number": "5.4.2.4", "activity": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+).", "evidence": [ { "id": "E1B959", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B959" } ] }, { "ec_number": "5.4.2.11", "activity": "", "evidence": [ { "id": "E1B959", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B959" } ] }, { "ec_number": "5.4.2.4", "activity": "", "evidence": [ { "id": "E1B959", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B959" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BNY9", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] } ] }, { "uniprot_ac": "F1MHT1", "gene_name": "AGL", "activity": [ { "ec_number": "2.4.1.25", "activity": "Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan.", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] }, { "ec_number": "3.2.1.33", "activity": "Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] }, { "ec_number": "3.2.1.33", "activity": "", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] }, { "ec_number": "2.4.1.25", "activity": "", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMR6", "gene_name": "CTSD", "activity": [ { "ec_number": "3.4.23.5", "activity": "Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.", "evidence": [ { "id": "F1MMR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMR6" } ] }, { "ec_number": "3.4.23.5", "activity": "", "evidence": [ { "id": "F1MMR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMR6" } ] } ] }, { "uniprot_ac": "F1MQ78", "gene_name": "ALOX5", "activity": [ { "ec_number": "1.13.11.34", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = leukotriene A4 + H2O.", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] }, { "ec_number": "1.13.11.12", "activity": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate.", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] }, { "ec_number": "1.13.11.34", "activity": "", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] }, { "ec_number": "1.13.11.12", "activity": "", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] } ] }, { "uniprot_ac": "F1MX69", "gene_name": "BPGM", "activity": [ { "ec_number": "5.4.2.11", "activity": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.", "evidence": [ { "id": "F1MX69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX69" } ] }, { "ec_number": "5.4.2.4", "activity": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+).", "evidence": [ { "id": "F1MX69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX69" } ] }, { "ec_number": "5.4.2.4", "activity": "", "evidence": [ { "id": "F1MX69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX69" } ] }, { "ec_number": "5.4.2.11", "activity": "", "evidence": [ { "id": "F1MX69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX69" } ] } ] }, { "uniprot_ac": "F1N2F2", "gene_name": "PGAM2", "activity": [ { "ec_number": "5.4.2.11", "activity": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.", "evidence": [ { "id": "F1N2F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2F2" } ] }, { "ec_number": "5.4.2.4", "activity": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+).", "evidence": [ { "id": "F1N2F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2F2" } ] }, { "ec_number": "5.4.2.11", "activity": "", "evidence": [ { "id": "F1N2F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2F2" } ] }, { "ec_number": "5.4.2.4", "activity": "", "evidence": [ { "id": "F1N2F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2F2" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O46414", "gene_name": "FTH1", "activity": [ { "ec_number": "1.16.3.1", "activity": "4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O.", "evidence": [ { "id": "O46414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46414" } ] }, { "ec_number": "1.16.3.1", "activity": "", "evidence": [ { "id": "O46414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46414" } ] } ] }, { "uniprot_ac": "P00432", "gene_name": "CAT", "activity": [ { "ec_number": "1.11.1.6", "activity": "2 H2O2 = O2 + 2 H2O.", "evidence": [ { "id": "P00432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00432" } ] }, { "ec_number": "1.11.1.6", "activity": "", "evidence": [ { "id": "P00432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00432" } ] } ] }, { "uniprot_ac": "P05689", "gene_name": "CTSZ", "activity": [ { "ec_number": "3.4.18.1", "activity": "Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.", "evidence": [ { "id": "P05689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05689" } ] }, { "ec_number": "3.4.18.1", "activity": "", "evidence": [ { "id": "P05689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05689" } ] } ] }, { "uniprot_ac": "P07688", "gene_name": "CTSB", "activity": [ { "ec_number": "3.4.22.1", "activity": "Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.", "evidence": [ { "id": "P07688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07688" } ] }, { "ec_number": "3.4.22.1", "activity": "", "evidence": [ { "id": "P07688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07688" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P25326", "gene_name": "CTSS", "activity": [ { "ec_number": "3.4.22.27", "activity": "Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.", "evidence": [ { "id": "P25326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25326" } ] }, { "ec_number": "3.4.22.27", "activity": "", "evidence": [ { "id": "P25326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25326" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P52176", "gene_name": "MMP9", "activity": [ { "ec_number": "3.4.24.35", "activity": "Cleavage of gelatin types I and V and collagen types IV and V.", "evidence": [ { "id": "P52176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52176" } ] }, { "ec_number": "3.4.24.35", "activity": "", "evidence": [ { "id": "P52176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52176" } ] } ] }, { "uniprot_ac": "P62935", "gene_name": "PPIA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P62935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62935" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P62935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62935" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P68401", "gene_name": "PAFAH1B2P68402", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P68401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68401" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "P68401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68401" } ] } ] }, { "uniprot_ac": "P80177", "gene_name": "MIF", "activity": [ { "ec_number": "5.3.2.1", "activity": "3-phenylpyruvate = enol-phenylpyruvate.", "evidence": [ { "id": "P80177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80177" } ] }, { "ec_number": "5.3.3.12", "activity": "L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.", "evidence": [ { "id": "P80177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80177" } ] }, { "ec_number": "5.3.2.1", "activity": "", "evidence": [ { "id": "P80177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80177" } ] }, { "ec_number": "5.3.3.12", "activity": "", "evidence": [ { "id": "P80177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80177" } ] } ] }, { "uniprot_ac": "P80227", "gene_name": "APEH", "activity": [ { "ec_number": "3.4.19.1", "activity": "Internal cleavage of oxidized and glycated proteins.", "evidence": [ { "id": "P80227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80227" } ] }, { "ec_number": "3.4.19.1", "activity": "", "evidence": [ { "id": "P80227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80227" } ] } ] }, { "uniprot_ac": "Q0II59", "gene_name": "PDXK", "activity": [ { "ec_number": "2.7.1.35", "activity": "pyridoxine + ATP = pyridoxine 5'-phosphate + ADP + H(+).", "evidence": [ { "id": "Q0II59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II59" } ] }, { "ec_number": "2.7.1.35", "activity": "", "evidence": [ { "id": "Q0II59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II59" } ] } ] }, { "uniprot_ac": "Q0VCM4", "gene_name": "PYGL", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "Q0VCM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCM4" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "Q0VCM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCM4" } ] } ] }, { "uniprot_ac": "Q17QB3", "gene_name": "ASAH1", "activity": [ { "ec_number": "3.5.1.23", "activity": "an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid.", "evidence": [ { "id": "Q17QB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB3" } ] }, { "ec_number": "3.5.1.23", "activity": "", "evidence": [ { "id": "Q17QB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB3" } ] }, { "ec_number": "3.5.1.-", "activity": "", "evidence": [ { "id": "Q17QB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB3" } ] } ] }, { "uniprot_ac": "Q27970", "gene_name": "CAPN1", "activity": [ { "ec_number": "3.4.22.52", "activity": "Broad endopeptidase specificity.", "evidence": [ { "id": "Q27970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27970" } ] }, { "ec_number": "3.4.22.52", "activity": "", "evidence": [ { "id": "Q27970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27970" } ] } ] }, { "uniprot_ac": "Q32KV0", "gene_name": "PGAM2", "activity": [ { "ec_number": "5.4.2.11", "activity": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.", "evidence": [ { "id": "Q32KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KV0" } ] }, { "ec_number": "5.4.2.4", "activity": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+).", "evidence": [ { "id": "Q32KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KV0" } ] }, { "ec_number": "5.4.2.11", "activity": "", "evidence": [ { "id": "Q32KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KV0" } ] }, { "ec_number": "5.4.2.4", "activity": "", "evidence": [ { "id": "Q32KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KV0" } ] } ] }, { "uniprot_ac": "Q32PF2", "gene_name": "ACLY", "activity": [ { "ec_number": "2.3.3.8", "activity": "oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA.", "evidence": [ { "id": "Q32PF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF2" } ] }, { "ec_number": "2.3.3.8", "activity": "", "evidence": [ { "id": "Q32PF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF2" } ] } ] }, { "uniprot_ac": "Q3SWY3", "gene_name": "IMPDH2", "activity": [ { "ec_number": "1.1.1.205", "activity": "IMP + NAD(+) + H2O = XMP + NADH + H(+).", "evidence": [ { "id": "Q3SWY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY3" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "Q3SWY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY3" } ] } ] }, { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q3SZ62", "gene_name": "PGAM1", "activity": [ { "ec_number": "5.4.2.11", "activity": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.", "evidence": [ { "id": "Q3SZ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ] }, { "ec_number": "5.4.2.4", "activity": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+).", "evidence": [ { "id": "Q3SZ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ] }, { "ec_number": "5.4.2.4", "activity": "", "evidence": [ { "id": "Q3SZ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ] }, { "ec_number": "5.4.2.11", "activity": "", "evidence": [ { "id": "Q3SZ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ] } ] }, { "uniprot_ac": "Q3SZH7", "gene_name": "LTA4H", "activity": [ { "ec_number": "3.3.2.6", "activity": "leukotriene A4 + H2O = leukotriene B4.", "evidence": [ { "id": "Q3SZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZH7" } ] }, { "ec_number": "3.4.11.4", "activity": "Release of the N-terminal residue from a tripeptide.", "evidence": [ { "id": "Q3SZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZH7" } ] }, { "ec_number": "3.3.2.6", "activity": "", "evidence": [ { "id": "Q3SZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZH7" } ] } ] }, { "uniprot_ac": "Q3T014", "gene_name": "BPGM", "activity": [ { "ec_number": "5.4.2.11", "activity": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.", "evidence": [ { "id": "Q3T014", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T014" } ] }, { "ec_number": "5.4.2.4", "activity": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+).", "evidence": [ { "id": "Q3T014", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T014" } ] }, { "ec_number": "5.4.2.4", "activity": "", "evidence": [ { "id": "Q3T014", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T014" } ] } ] }, { "uniprot_ac": "Q3T0A3", "gene_name": "CFD", "activity": [ { "ec_number": "3.4.21.46", "activity": "Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.", "evidence": [ { "id": "Q3T0A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0A3" } ] }, { "ec_number": "3.4.21.46", "activity": "", "evidence": [ { "id": "Q3T0A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0A3" } ] } ] }, { "uniprot_ac": "Q3T0Q4", "gene_name": "NME2", "activity": [ { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] }, { "ec_number": "2.7.13.3", "activity": "", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] } ] }, { "uniprot_ac": "Q3T0V9", "gene_name": "DERA", "activity": [ { "ec_number": "4.1.2.4", "activity": "2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.", "evidence": [ { "id": "Q3T0V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0V9" } ] }, { "ec_number": "4.1.2.4", "activity": "", "evidence": [ { "id": "Q3T0V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0V9" } ] } ] }, { "uniprot_ac": "Q3ZBD7", "gene_name": "GPI", "activity": [ { "ec_number": "5.3.1.9", "activity": "alpha-D-fructose 6-phosphate = beta-D-fructose 6-phosphate.", "evidence": [ { "id": "Q3ZBD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD7" } ] }, { "ec_number": "5.3.1.9", "activity": "", "evidence": [ { "id": "Q3ZBD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD7" } ] }, { "ec_number": "5.1.3.-", "activity": "", "evidence": [ { "id": "Q3ZBD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD7" } ] } ] }, { "uniprot_ac": "Q3ZCI9", "gene_name": "CCT8", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ] } ] }, { "uniprot_ac": "Q56JW4", "gene_name": "APRT", "activity": [ { "ec_number": "2.4.2.7", "activity": "AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine.", "evidence": [ { "id": "Q56JW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ] }, { "ec_number": "2.4.2.7", "activity": "", "evidence": [ { "id": "Q56JW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ] } ] }, { "uniprot_ac": "Q58DK5", "gene_name": "ALAD", "activity": [ { "ec_number": "4.2.1.24", "activity": "2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+).", "evidence": [ { "id": "Q58DK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DK5" } ] }, { "ec_number": "4.2.1.24", "activity": "", "evidence": [ { "id": "Q58DK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DK5" } ] } ] }, { "uniprot_ac": "Q76LV2", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ62-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 254, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ62-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ62" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "5.4.2.11", "ec_name": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.", "evidence": [ { "id": "5.4.2.11", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11" }, { "id": "5.4.2.11", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=5.4.2.11" } ] }, { "ec_number": "5.4.2.4", "ec_name": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+).", "evidence": [ { "id": "5.4.2.4", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4" }, { "id": "5.4.2.4", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=5.4.2.4" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 14, 23, 26, 31, 118 ], "sequon_annotation_sites": [ { "start_pos": 135, "end_pos": 137 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZ63-1", "uniprot_ac": "Q3SZ63", "uniprot_id": "NOP56_BOVIN", "mass": { "chemical_mass": 66331.0, "monoisotopic_mass": 66331.0 }, "refseq": { "ac": "NP_001028794", "name": "nucleolar protein 56", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028794" }, "gene_names": [ { "name": "NOP56", "type": "recommended", "evidence": [ { "id": "Q3SZ63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" } ] }, { "name": "NOL5A", "type": "synonym", "evidence": [ { "id": "NP_001028794", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028794" }, { "id": "Q3SZ63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" } ] }, { "name": "NOP56", "type": "synonym", "evidence": [ { "id": "NP_001028794", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028794" } ] } ], "protein_names": [ { "name": "Nucleolar protein 56", "type": "recommended", "evidence": [ { "id": "Q3SZ63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63/entry#names_and_taxonomy" } ] }, { "name": "NOP56 ribonucleoprotein homolog", "type": "synonym", "evidence": [ { "id": "NP_001028794", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028794" } ] }, { "name": "Nucleolar protein 5A", "type": "synonym", "evidence": [ { "id": "Q3SZ63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63/entry#names_and_taxonomy" } ] }, { "name": "nucleolar protein 56", "type": "synonym", "evidence": [ { "id": "NP_001028794", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028794" } ] }, { "name": "nucleolar protein 5A (56kDa with KKE/D repeat)", "type": "synonym", "evidence": [ { "id": "NP_001028794", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028794" } ] } ], "function": [ { "annotation": "Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ63", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63#function" }, { "database": "UniProtKB", "id": "O00567", "url": "https://www.uniprot.org/uniprotkb/O00567#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZ63", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NOP56", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63", "locus": { "chromosome": "13", "start_pos": 52519429, "end_pos": 52524666, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018812", "url": "https://www.ensembl.org/id/ENSBTAG00000018812" } ] } } ], "crossref": [ { "id": "Q3SZ63", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZ63", "database": "AlphaFoldDB", "categories": [] }, { "id": "404165", "url": "https://www.ncbi.nlm.nih.gov/gene/404165", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002687", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002687", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012976", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012976", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036070", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036070", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042239", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042239", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:404165", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404165", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZ63", "url": "https://www.orthodb.org/?gene=Q3SZ63", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10894", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10894", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10894:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10894:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01798", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01798", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08156", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08156", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001028794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028794", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZ63", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ63-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLLHVLFEHAVGYALLALKEVEEIILLLPQVEECVLNLGKFHNIVRLVAFCPFSSSQVALENANAVSEGVVHEDLRLLLETHLPPKKKKVLLGVGDPKIGAAIQEELGYNCQTGGVIAEILRGVRLHFHNLVKGLTDLSACKAQLGLGHSYSRAKVKFNVNRVDNMIIQSISLLDQLDKDINTFSMRVREWYGYHFPELVKIINDNATYCRLAQFIGNRKELNEEKLEKLEELTMDAAKAKAILDASRSSMGMDISAIDLINIESFSSRVVSLSEYRQSLHTYLRSKMSQVAPSLSALIGEAVGARLIAHAGSLTNLAKYPASTVQILGAEKALFRALKTRGNTPKYGLIFHSTFIGRAAAKNKGRISRYLANKCSIASRIDCFSEVPTSVFGEKLREQVEERLSFYETGEIPRKNLDVMKEAMVQAEEAAAEITRKLEKQEKKRLKKEKKRLAAIALASSENSSAPEECEETSERPKKKKKQKPQEVLQENGMEDPSVSFSKPKKKKSFSKEELVSSDLEETAGTGSLPKRKKSFPKEEPVTDPDESENKRVPKKKRKLSPKEEPLSSGPEEAAASKSSGSKKKKKLRKLSQES", "length": 596, "header": "sp|Q3SZ63-1|NOP56_BOVIN Isoform 1 of Nucleolar protein 56 OS=Bos taurus OX=9913 GN=NOP56 PE=2 SV=1 CANONICAL=Q3SZ63-1" }, "isoforms": [ { "isoform_ac": "Q3SZ63-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63/entry#Q3SZ63-1", "sequence": { "sequence": "MVLLHVLFEHAVGYALLALKEVEEIILLLPQVEECVLNLGKFHNIVRLVAFCPFSSSQVALENANAVSEGVVHEDLRLLLETHLPPKKKKVLLGVGDPKIGAAIQEELGYNCQTGGVIAEILRGVRLHFHNLVKGLTDLSACKAQLGLGHSYSRAKVKFNVNRVDNMIIQSISLLDQLDKDINTFSMRVREWYGYHFPELVKIINDNATYCRLAQFIGNRKELNEEKLEKLEELTMDAAKAKAILDASRSSMGMDISAIDLINIESFSSRVVSLSEYRQSLHTYLRSKMSQVAPSLSALIGEAVGARLIAHAGSLTNLAKYPASTVQILGAEKALFRALKTRGNTPKYGLIFHSTFIGRAAAKNKGRISRYLANKCSIASRIDCFSEVPTSVFGEKLREQVEERLSFYETGEIPRKNLDVMKEAMVQAEEAAAEITRKLEKQEKKRLKKEKKRLAAIALASSENSSAPEECEETSERPKKKKKQKPQEVLQENGMEDPSVSFSKPKKKKSFSKEELVSSDLEETAGTGSLPKRKKSFPKEEPVTDPDESENKRVPKKKRKLSPKEEPLSSGPEEAAASKSSGSKKKKKLRKLSQES", "length": 596, "header": "sp|Q3SZ63-1|NOP56_BOVIN Isoform 1 of Nucleolar protein 56 OS=Bos taurus OX=9913 GN=NOP56 PE=2 SV=1 CANONICAL=Q3SZ63-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": 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"Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ63", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" } ], "site_lbl": "Ser466" }, { "start_pos": 510, "end_pos": 510, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ63", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" } ], "site_lbl": "Ser510" }, { "start_pos": 518, "end_pos": 518, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ63", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" } ], "site_lbl": "Ser518" }, { "start_pos": 519, "end_pos": 519, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ63", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" } ], "site_lbl": "Ser519" }, { "start_pos": 536, "end_pos": 536, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ63", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" } ], "site_lbl": "Ser536" }, { "start_pos": 562, "end_pos": 562, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ63", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" } ], "site_lbl": "Ser562" }, { "start_pos": 569, "end_pos": 569, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ63", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" } ], "site_lbl": "Ser569" }, { "start_pos": 570, "end_pos": 570, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ63", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" } ], "site_lbl": "Ser570" }, { "start_pos": 581, "end_pos": 581, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ63", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" } ], "site_lbl": "Ser581" }, { "start_pos": 583, "end_pos": 583, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ63", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" } ], "site_lbl": "Ser583" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Epigenetic co-regulator HCF-1 promotes lung cancer via O-GlcNAcylation-dependent pathways.", "journal": "Molecular therapy. Oncology", "date": "2025-12-18", "authors": "Srivastava Priyanka P, Dasari Abhilash, Kumar Saran, Gupta Ishaan, Jain Deepali, Minocha Shilpi", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q3SZ63", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q3SZ63" } ], "reference": [ { "type": "PubMed", "id": "41018975", "url": "https://glygen.org/publication/PubMed/41018975" } ] } ], "pathway": [ { "id": "bta:404165", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404165", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ63", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ63", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" } ], "pmid": "" }, { "name": "box C/D methylation guide snoRNP complex", "id": "GO:0031428", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031428", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ63", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" } ], "pmid": "" }, { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ63", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "snoRNA binding", "id": "GO:0030515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030515", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ63", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ribosomal small subunit biogenesis", "id": "GO:0042274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042274", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ63", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 464, "end_pos": 466, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ63-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 596, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ63-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ63" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SZ63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ63" }, { "id": "PRU00690", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00690" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nop", "eco_id": "ECO_0000255", "start_pos": 292, "end_pos": 410, "start_aa": "Val", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 314, 465, 466, 510, 518, 519, 536, 562, 569, 570, 581, 583 ], "sequon_annotation_sites": [ { "start_pos": 207, "end_pos": 209 }, { "start_pos": 464, "end_pos": 466 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": 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"table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 0 }, { "field": "fuzzy_sites", "count": 1 }, { "field": "fuzzy_o_linked_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycan_sites", "count": 1 }, { "field": "fuzzy_o_linked_glycans", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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}, { "id": "IPR044728", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044728", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:286819", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:286819", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FGCQALV", "url": "https://omabrowser.org/oma/group/FGCQALV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZ65", "url": "https://www.orthodb.org/?gene=Q3SZ65", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47958", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47958", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00270", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00270", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029216", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZ65", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ65-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI", "length": 407, "header": "sp|Q3SZ65-1|IF4A2_BOVIN Isoform 1 of Eukaryotic initiation factor 4A-II OS=Bos taurus OX=9913 GN=EIF4A2 PE=2 SV=1 CANONICAL=Q3SZ65-1" }, "isoforms": [ { "isoform_ac": "Q3SZ65-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65/entry#Q3SZ65-1", "sequence": { "sequence": "MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI", "length": 407, "header": "sp|Q3SZ65-1|IF4A2_BOVIN Isoform 1 of Eukaryotic initiation factor 4A-II OS=Bos taurus OX=9913 GN=EIF4A2 PE=2 SV=1 CANONICAL=Q3SZ65-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 159, "end_pos": 159, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ65", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ], "site_lbl": "Thr159" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Copy number variation of EIF4A2 loci related to phenotypic traits in Chinese cattle.", "journal": "Veterinary medicine and science", "date": "2022-09", "authors": "Zhang Zijing, Peng Mengyang, Wen Yifan, Chai Yanan, Liang Juntong, Yang Peng, Liu Xian, Li Jungang, Huang Yajun, Li Lijuan, Huang Weihong, Qi Zengfang, Yang Guojie, Chen Fuying, Shi Qiaoting, Li Zhiming, Ru Baorui, Lei Chuzhao, Wang Eryao, Huang Yongzhen", "evidence": [ { "database": "RefSeq", "id": "NP_001029216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029216" } ], "reference": [ { "type": "PubMed", "id": "36052549", "url": "https://glygen.org/publication/PubMed/36052549" } ] } ], "pathway": [ { "id": "bta:286819", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:286819", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7FU33-1", "protein_name": "RNA helicase", "gene_name": "Eif4a2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSGGSADYNSREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI", "length": 408 }, "evidence": [ { "id": "Q3SZ65", "url": "https://omabrowser.org/oma/group/Q3SZ65/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1R166-1", "protein_name": "RNA helicase", "gene_name": "eif4a2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSSGSADYNSSRDRDHGGPEGMEPDGVIESNWNEITDNFDDMNLKETLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEQKETQALVLAPTRELAQQIQKVILALGDYMGASCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLSTNIQVVLLSATMPADVLEVTTKFMREPVRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDIIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI", "length": 411 }, "evidence": [ { "id": "Q3SZ65", "url": "https://omabrowser.org/oma/group/Q3SZ65/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P10081-1", "protein_name": "ATP-dependent RNA helicase eIF4A", "gene_name": "TIF1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSEGITDIEESQIQTNYDKVVYKFDDMELDENLLRGVFGYGFEEPSAIQQRAIMPIIEGHDVLAQAQSGTGKTGTFSIAALQRIDTSVKAPQALMLAPTRELALQIQKVVMALAFHMDIKVHACIGGTSFVEDAEGLRDAQIVVGTPGRVFDNIQRRRFRTDKIKMFILDEADEMLSSGFKEQIYQIFTLLPPTTQVVLLSATMPNDVLEVTTKFMRNPVRILVKKDELTLEGIKQFYVNVEEEEYKYECLTDLYDSISVTQAVIFCNTRRKVEELTTKLRNDKFTVSAIYSDLPQQERDTIMKEFRSGSSRILISTDLLARGIDVQQVSLVINYDLPANKENYIHRIGRGGRFGRKGVAINFVTNEDVGAMRELEKFYSTQIEELPSDIATLLN", "length": 395 }, "evidence": [ { "id": "Q3SZ65", "url": "https://omabrowser.org/oma/group/Q3SZ65/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P10630-1", "protein_name": "Eukaryotic initiation factor 4A-II", "gene_name": "Eif4a2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI", "length": 407 }, "evidence": [ { "id": "Q3SZ65", "url": "https://omabrowser.org/oma/group/Q3SZ65/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P41376-1", "protein_name": "Eukaryotic initiation factor 4A-1", "gene_name": "EIF4A1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAGSAPEGTQFDARQFDQKLNEVLEGQDEFFTSYDDVHESFDAMGLQENLLRGIYAYGFEKPSAIQQRGIVPFCKGLDVIQQAQSGTGKTATFCSGVLQQLDFSLIQCQALVLAPTRELAQQIEKVMRALGDYLGVKVHACVGGTSVREDQRILQAGVHVVVGTPGRVFDMLKRQSLRADNIKMFVLDEADEMLSRGFKDQIYDIFQLLPPKIQVGVFSATMPPEALEITRKFMSKPVRILVKRDELTLEGIKQFYVNVEKEEWKLETLCDLYETLAITQSVIFVNTRRKVDWLTDKMRSRDHTVSATHGDMDQNTRDIIMREFRSGSSRVLITTDLLARGIDVQQVSLVINFDLPTQPENYLHRIGRSGRFGRKGVAINFVTRDDERMLFDIQKFYNVVVEELPSNVADLL", "length": 412 }, "evidence": [ { "id": "Q3SZ65", "url": "https://omabrowser.org/oma/group/Q3SZ65/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q02748-1", "protein_name": "Eukaryotic initiation factor 4A", "gene_name": "eIF4A", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDDRNEIPQDGPASMEPEGVIESTWHEVYDNFDDMNLREELLRGIYGYGFEKPSAIQQRAIIPCVRGRDVIAQAQSGTGKTATFSIAILQQIDTSIRECQALILAPTRELATQIQRVVMALGEYMKVHSHACIGGTNVREDARILESGCHVVVGTPGRVYDMINRKVLRTQYIKLFVLDEADEMLSRGFKDQIQDVFKMLPPDVQVILLSATMPPDVLEVSRCFMRDPVSILVKKEELTLEGIKQFYVNVKQENWKLGTLCDLYDTLSITQSVIFCNTRRKVDQLTQEMSIHNFTVSAMHGDMEQRDREVIMKQFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPSNRENYIHRIGRGGRFGRKGVAINFITDDDRRILKDIEQFYHTTIEEMPANIADLI", "length": 403 }, "evidence": [ { "id": "Q3SZ65", "url": "https://omabrowser.org/oma/group/Q3SZ65/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q14240-1", "protein_name": "Eukaryotic initiation factor 4A-II", "gene_name": "EIF4A2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI", "length": 407 }, "evidence": [ { "id": "Q3SZ65", "url": "https://omabrowser.org/oma/group/Q3SZ65/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5RKI1-1", "protein_name": "Eukaryotic initiation factor 4A-II", "gene_name": "Eif4a2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI", "length": 407 }, "evidence": [ { "id": "Q3SZ65", "url": "https://omabrowser.org/oma/group/Q3SZ65/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8JFP1-1", "protein_name": "Eukaryotic initiation factor 4A-II", "gene_name": "EIF4A2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGGSADYSRDHGGPEGMEPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIDLKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLSTNIQVVLLSATMPMDVLEVTKKFMREPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI", "length": 407 }, "evidence": [ { "id": "Q3SZ65", "url": "https://omabrowser.org/oma/group/Q3SZ65/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ65", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ65", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ65", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ], "pmid": "" }, { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ65", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ65", "url": "https://www.uniprot.org/uniprotkb/Q3SZ65" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 205, "end_pos": 207, "annotation": "n_glycosylation_sequon" }, { "start_pos": 393, "end_pos": 395, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": 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"evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { 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"evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { 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"https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": 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+ phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": 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"ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": 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5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": 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"id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TBP1", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": 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"id": "NP_001029689", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029689" } ] }, { "name": "hepatitis B virus x interacting protein", "type": "synonym", "evidence": [ { "id": "NP_001029689", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029689" } ] }, { "name": "late endosomal/lysosomal adaptor and MAPK and MTOR activator 5", "type": "synonym", "evidence": [ { "id": "NP_001029689", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029689" } ] }, { "name": "ragulator complex protein LAMTOR5", "type": "synonym", "evidence": [ { "id": "NP_001029689", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029689" } ] } ], "function": [ { "annotation": "As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. 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"id": "IPR050361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534546", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534546", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZ71", "url": "https://www.orthodb.org/?gene=Q3SZ71", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11851", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11851", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11851:SF103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11851:SF103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00675", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00675", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05193", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05193", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029785", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZ71", "url": "https://www.uniprot.org/uniprotkb/Q3SZ71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZ71-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ71-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAAVARAVLFSAARRRLCGFTERLLIGGAAGRSLYFGGNRLRSTQAAAQVVLNVPETRVTCLENGLRVASEDSGLATCTVGLWIDAGSRYENEKNNGTAHFLEHMAFKGTKKRSQLDLELEIENMGAHLNAYTSREQTVYYAKAFSKDLPRAVEILADIIQNSTLGEAEIERERGVILREMQEVETNLQEVVFDYLHATAYQNTALGRTILGPTENIKSINRKDLVDYITTHYKGPRIVLAAAGGVSHDELLELAKFHFGESLSTHKGEIPALPPCKFTGSEIRVRDDKMPLAHLAVAVEAVGWAHPDTICLMVANTLIGNWDRSFGGGMNLSSKLAQLTCHGNLCHSFQSFNTSYTDTGLWGIYMVCEPATVADMLHVVQKEWMRLCTSVTESEVARAKNLLKTNMLLQLDGSTPICEDIGRQMLCYNRRIPIPELEARIDAVNAEIIREVCTKYIYDKSPAVAAVGPIEQLPDFNQICSNMRWLHD", "length": 490, "header": "sp|Q3SZ71-1|MPPB_BOVIN Isoform 1 of Mitochondrial-processing peptidase subunit beta OS=Bos taurus OX=9913 GN=PMPCB PE=2 SV=1 CANONICAL=Q3SZ71-1" }, "isoforms": [ { "isoform_ac": "Q3SZ71-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZ71/entry#Q3SZ71-1", "sequence": { "sequence": "MAAAAVARAVLFSAARRRLCGFTERLLIGGAAGRSLYFGGNRLRSTQAAAQVVLNVPETRVTCLENGLRVASEDSGLATCTVGLWIDAGSRYENEKNNGTAHFLEHMAFKGTKKRSQLDLELEIENMGAHLNAYTSREQTVYYAKAFSKDLPRAVEILADIIQNSTLGEAEIERERGVILREMQEVETNLQEVVFDYLHATAYQNTALGRTILGPTENIKSINRKDLVDYITTHYKGPRIVLAAAGGVSHDELLELAKFHFGESLSTHKGEIPALPPCKFTGSEIRVRDDKMPLAHLAVAVEAVGWAHPDTICLMVANTLIGNWDRSFGGGMNLSSKLAQLTCHGNLCHSFQSFNTSYTDTGLWGIYMVCEPATVADMLHVVQKEWMRLCTSVTESEVARAKNLLKTNMLLQLDGSTPICEDIGRQMLCYNRRIPIPELEARIDAVNAEIIREVCTKYIYDKSPAVAAVGPIEQLPDFNQICSNMRWLHD", "length": 490, "header": "sp|Q3SZ71-1|MPPB_BOVIN Isoform 1 of Mitochondrial-processing peptidase subunit beta OS=Bos taurus OX=9913 GN=PMPCB PE=2 SV=1 CANONICAL=Q3SZ71-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:534546", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534546", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metalloendopeptidase activity", "id": "GO:0004222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ71", "url": "https://www.uniprot.org/uniprotkb/Q3SZ71" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ71", "url": "https://www.uniprot.org/uniprotkb/Q3SZ71" } ], "pmid": "" }, { "name": "signal peptidase activity", "id": "GO:0009003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009003", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ71", "url": "https://www.uniprot.org/uniprotkb/Q3SZ71" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein processing involved in protein targeting to mitochondrion", "id": "GO:0006627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006627", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ71", "url": "https://www.uniprot.org/uniprotkb/Q3SZ71" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial processing peptidase complex", "id": "GO:0017087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017087", "evidence": [ { "database": "UniProtKB", "id": "Q3SZ71", "url": "https://www.uniprot.org/uniprotkb/Q3SZ71" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 333, "end_pos": 335, "annotation": "n_glycosylation_sequon" }, { "start_pos": 355, "end_pos": 357, "annotation": "n_glycosylation_sequon" }, { "start_pos": 98, "end_pos": 100, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZ71-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 490, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZ71-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZ71" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q3SZ71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ71#function" }, { "id": "Q3SZ71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ71" }, { "id": "PRU10096", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU10096" } ], "binding_site_uniprot": 102, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 102, "end_pos": 102, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZ71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ71#function" }, { "id": "Q3SZ71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ71" }, { "id": "PRU10096", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU10096" } ], "binding_site_uniprot": 106, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 106, "end_pos": 106, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZ71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ71#function" }, { "id": "Q3SZ71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ71" }, { "id": "PRU10096", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU10096" } ], "binding_site_uniprot": 182, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 182, "end_pos": 182, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.24.64", "ec_name": "Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.", "evidence": [ { "id": "3.4.24.64", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.24.64" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 164, "end_pos": 166 }, { "start_pos": 333, "end_pos": 335 }, { "start_pos": 355, "end_pos": 357 }, { "start_pos": 98, "end_pos": 100 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZB3-1", "uniprot_ac": "Q3SZB3", "uniprot_id": "TIM50_BOVIN", "mass": { "chemical_mass": 40109.0, "monoisotopic_mass": 40109.0 }, "refseq": { "ac": "NP_001030196", "name": "mitochondrial import inner membrane translocase subunit TIM50 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030196" }, "gene_names": [ { "name": "TIMM50", "type": "recommended", "evidence": [ { "id": "Q3SZB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZB3" } ] }, { "name": "TIM50", "type": "synonym", "evidence": [ { "id": "Q3SZB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZB3" } ] }, { "name": "TIMM50", "type": "synonym", "evidence": [ { "id": "NP_001030196", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030196" } ] } ], "protein_names": [ { "name": "Mitochondrial import inner membrane translocase subunit TIM50", "type": "recommended", "evidence": [ { "id": "Q3SZB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZB3/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial import inner membrane translocase subunit TIM50 precursor", "type": "synonym", "evidence": [ { "id": "NP_001030196", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030196" } ] }, { "name": "mitochondrial import inner membrane translocase subunit TIM50", "type": "synonym", "evidence": [ { "id": "NP_001030196", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030196" } ] } ], "function": [ { "annotation": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZB3", "url": "https://www.uniprot.org/uniprotkb/Q3SZB3#function" }, { "database": "UniProtKB", "id": "Q3ZCQ8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCQ8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZB3", "url": "https://www.uniprot.org/uniprotkb/Q3SZB3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TIMM50", "url": "https://www.uniprot.org/uniprotkb/Q3SZB3", "locus": { "chromosome": "18", "start_pos": 49168042, "end_pos": 49160932, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010480", "url": "https://www.ensembl.org/id/ENSBTAG00000010480" } ] } } ], "crossref": [ { "id": "Q3SZB3", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZB3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07521", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07521", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505489", "url": "https://www.ncbi.nlm.nih.gov/gene/505489", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004274", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004274", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505489", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505489", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZB3", "url": "https://www.orthodb.org/?gene=Q3SZB3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12210", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12210", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03031", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03031", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030196", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZB3", "url": "https://www.uniprot.org/uniprotkb/Q3SZB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZB3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZB3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASAAVFLRLRSGLRQGARGLCARLATPPPRAPDQAAEIGSRAGTKAQTQGPQQQRSSEGPSYAKKVALWLARLLGAGGTVSVIYIFGNNAVDENGAKIPDEFDNDPILVQQLRRTYKYFKDYRQMIIEPTSPCLLPDPLREPYYQPPYTLVLELTGVLLHPEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEEDPLEAFKQRQSRLEQEEQQRLAELSKSSKQNLFFSSLTSRLWPRSKQP", "length": 355, "header": "sp|Q3SZB3-1|TIM50_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit TIM50 OS=Bos taurus OX=9913 GN=TIMM50 PE=2 SV=1 CANONICAL=Q3SZB3-1" }, "isoforms": [ { "isoform_ac": "Q3SZB3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZB3/entry#Q3SZB3-1", "sequence": { "sequence": "MAASAAVFLRLRSGLRQGARGLCARLATPPPRAPDQAAEIGSRAGTKAQTQGPQQQRSSEGPSYAKKVALWLARLLGAGGTVSVIYIFGNNAVDENGAKIPDEFDNDPILVQQLRRTYKYFKDYRQMIIEPTSPCLLPDPLREPYYQPPYTLVLELTGVLLHPEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEEDPLEAFKQRQSRLEQEEQQRLAELSKSSKQNLFFSSLTSRLWPRSKQP", "length": 355, "header": "sp|Q3SZB3-1|TIM50_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit TIM50 OS=Bos taurus OX=9913 GN=TIMM50 PE=2 SV=1 CANONICAL=Q3SZB3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 343, "end_pos": 343, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZB3", "url": "https://www.uniprot.org/uniprotkb/Q3SZB3" } ], "site_lbl": "Ser343" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505489", "name": "", "url": 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"GRPE1_BOVIN", "mass": { "chemical_mass": 24306.0, "monoisotopic_mass": 24306.0 }, "refseq": { "ac": "NP_001029673", "name": "grpE protein homolog 1, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029673" }, "gene_names": [ { "name": "GRPEL1", "type": "recommended", "evidence": [ { "id": "Q3SZC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZC1" } ] }, { "name": "GRPEL1", "type": "synonym", "evidence": [ { "id": "NP_001029673", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029673" } ] } ], "protein_names": [ { "name": "GrpE protein homolog 1, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q3SZC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZC1/entry#names_and_taxonomy" } ] }, { "name": "Mt-GrpE#1", "type": "synonym", "evidence": [ { "id": "Q3SZC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZC1/entry#names_and_taxonomy" } ] }, { "name": "grpE protein homolog 1, mitochondrial precursor", "type": "synonym", "evidence": [ { "id": "NP_001029673", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029673" } ] }, { "name": "grpE protein homolog 1, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001029673", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029673" } ] }, { "name": "mt-GrpE#1", "type": "synonym", "evidence": [ { "id": "NP_001029673", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029673" } ] }, { "name": "mt-GrpE", "type": "synonym", "evidence": [ { "id": "NP_001029673", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029673" }, { "id": "Q3SZC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZC1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZC1", "url": "https://www.uniprot.org/uniprotkb/Q3SZC1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZC1", "url": "https://www.uniprot.org/uniprotkb/Q3SZC1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GRPEL1", "url": "https://www.uniprot.org/uniprotkb/Q3SZC1", "locus": { "chromosome": "6", "start_pos": 113529004, "end_pos": 113543058, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010181", "url": "https://www.ensembl.org/id/ENSBTAG00000010181" } ] } } ], "crossref": [ { "id": "Q3SZC1", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZC1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010181", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010181", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00446", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00446", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515580", "url": "https://www.ncbi.nlm.nih.gov/gene/515580", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000740", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000740", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013805", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013805", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515580", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515580", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PHRHQAI", "url": "https://omabrowser.org/oma/group/PHRHQAI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZC1", "url": "https://www.orthodb.org/?gene=Q3SZC1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21237", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21237", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21237:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21237:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01025", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01025", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029673", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZC1", "url": "https://www.uniprot.org/uniprotkb/Q3SZC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZC1-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZC1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAARCVRLARGSLPAFALSLRSSPRLLCTAAKQKNNGQNLEEDAGQNEQKTDLPSTEKTLMEEKVKLEEQLKETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQCVPQEEIRDDNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLNPLGAKFDPYEHEALFHTPVEGKEPGTVALVNKVGYKLHGRTLRPALVGVVKGA", "length": 217, "header": "sp|Q3SZC1-1|GRPE1_BOVIN Isoform 1 of GrpE protein homolog 1, mitochondrial OS=Bos taurus OX=9913 GN=GRPEL1 PE=1 SV=1 CANONICAL=Q3SZC1-1" }, "isoforms": [ { "isoform_ac": "Q3SZC1-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZC1/entry#Q3SZC1-1", "sequence": { "sequence": "MAARCVRLARGSLPAFALSLRSSPRLLCTAAKQKNNGQNLEEDAGQNEQKTDLPSTEKTLMEEKVKLEEQLKETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQCVPQEEIRDDNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLNPLGAKFDPYEHEALFHTPVEGKEPGTVALVNKVGYKLHGRTLRPALVGVVKGA", "length": 217, "header": "sp|Q3SZC1-1|GRPE1_BOVIN Isoform 1 of GrpE protein homolog 1, mitochondrial OS=Bos taurus OX=9913 GN=GRPEL1 PE=1 SV=1 CANONICAL=Q3SZC1-1" }, "locus": { "chromosome": "6", "start_pos": 113543038, "end_pos": 113529757, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013431.4", "url": "https://www.ensembl.org/id/ENSBTAT00000013431.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013431.3", "url": "https://www.ensembl.org/id/ENSBTAP00000013431.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Affinity-purification and identification of GrpE homologues from mammalian mitochondria.", "journal": "Biochim. Biophys. Acta", "date": "1995", "authors": "Naylor D J, Ryan M T, Condron R, Hoogenraad N J, H\u00f8j P B", "evidence": [ { "database": "UniProtKB", "id": "Q3SZC1", "url": "https://www.uniprot.org/uniprotkb/Q3SZC1" } ], "reference": [ { "type": "PubMed", "id": "7711059", "url": "https://glygen.org/publication/PubMed/7711059" } ] } ], "pathway": [ { "id": "bta:515580", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515580", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LRV2-1", "protein_name": "GrpE protein homolog", "gene_name": "Grpel1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAARCVRLARRSLPALALSFRPSPRLLCTATKQKNGQNLEEDLGHCEPKTEPPSADKTLLEEKVKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKEEISNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVKEA", "length": 216 }, "evidence": [ { "id": "Q3SZC1", "url": "https://omabrowser.org/oma/group/Q3SZC1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P38523-1", "protein_name": "GrpE protein homolog, mitochondrial", "gene_name": "MGE1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MRAFSAATVRATTRKSFIPMAPRTPFVTPSFTKNVGSMRRMRFYSDEAKSEESKENNEDLTEEQSEIKKLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESVDNFGHALNAFKEEDLQKSKEISDLYTGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTVFHVQQLGFTLNDRVIRPAKVGIVKGEEN", "length": 228 }, "evidence": [ { "id": "Q3SZC1", "url": "https://omabrowser.org/oma/group/Q3SZC1/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P48604-1", "protein_name": "GrpE protein homolog, mitochondrial", "gene_name": "Roe1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSAKAALPLQMFGRRLVHLRSSVTSQNMSALRLYSTEKQPEEATEQKATESSPEVEKLTKELAAAKEQNAELMDKYKRSLADSENMRNRLNKQISDAKIFGIQSFCKDLLEVADTLGHATQAVPKDKLSGNADLKNLYEGLTMTRASLLQVFKRHGLEPLDPINQKFDPNQHEALFQKEDKTVEPNTVVEVTKLGYKLHERCIRPALVGVSKC", "length": 213 }, "evidence": [ { "id": "Q3SZC1", "url": "https://omabrowser.org/oma/group/Q3SZC1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P97576-1", "protein_name": "GrpE protein homolog 1, mitochondrial", "gene_name": "Grpel1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAARCVRLARRSLPALALSFRPSPRLLCTATKQKNNGQNLEEDLGHCEPKTDPSSADKTLLEEKVKLEEQLKETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKEEVSNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVKDA", "length": 217 }, "evidence": [ { "id": "Q3SZC1", "url": "https://omabrowser.org/oma/group/Q3SZC1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q54QF9-1", "protein_name": "GrpE protein homolog, mitochondrial", "gene_name": "grpE", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNSLIRRGLVSIRTSTVIKPSSFGLMRNNRFYSTENNQEAAKPEETENKPAPGSLEETIEKLKEELEETKKQLLYTAADRENVRRFAKEDNEKAKKFGIQSFTKELLEVVDQLEMATNLFPKEKLDENKELKDLHEGVKMTEQLFLKIMGNQGLQRFNPIGEKFDFNNHHAIFELNDPTKENNTVGHVVKQGYKLHDRLVRPAMVGVNKIKPQ", "length": 213 }, "evidence": [ { "id": "Q3SZC1", "url": "https://omabrowser.org/oma/group/Q3SZC1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q99LP6-1", "protein_name": "GrpE protein homolog 1, mitochondrial", "gene_name": "Grpel1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAARCVRLARRSLPALALSFRPSPRLLCTATKQKNNGQNLDEDLGHCEPKTDPPSADKTLLEEKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKEEISNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVKDA", "length": 217 }, "evidence": [ { "id": "Q3SZC1", "url": "https://omabrowser.org/oma/group/Q3SZC1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HAV7-1", "protein_name": "GrpE protein homolog 1, mitochondrial", "gene_name": "GRPEL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAQCVRLARRSLPALALSLRPSPRLLCTATKQKNSGQNLEEDMGQSEQKADPPATEKTLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQCVPKEEIKDDNPHLKNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVKEA", "length": 217 }, "evidence": [ { "id": "Q3SZC1", "url": "https://omabrowser.org/oma/group/Q3SZC1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q3SZC1", "url": "https://www.uniprot.org/uniprotkb/Q3SZC1" } ], "pmid": "" }, { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "Q3SZC1", "url": "https://www.uniprot.org/uniprotkb/Q3SZC1" } ], "pmid": "" }, { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "Q3SZC1", "url": "https://www.uniprot.org/uniprotkb/Q3SZC1" } ], "pmid": "" }, { "name": "adenyl-nucleotide exchange factor activity", "id": "GO:0000774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000774", "evidence": [ { "database": "UniProtKB", "id": "Q3SZC1", "url": "https://www.uniprot.org/uniprotkb/Q3SZC1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "Q3SZC1", "url": "https://www.uniprot.org/uniprotkb/Q3SZC1" } ], "pmid": "" }, { "name": "protein import into mitochondrial matrix", "id": "GO:0030150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030150", "evidence": [ { "database": "UniProtKB", "id": "Q3SZC1", "url": "https://www.uniprot.org/uniprotkb/Q3SZC1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "PAM complex, Tim23 associated import motor", "id": "GO:0001405", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001405", "evidence": [ { "database": "UniProtKB", "id": "Q3SZC1", "url": "https://www.uniprot.org/uniprotkb/Q3SZC1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], 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"field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3SZE9-1", "uniprot_ac": "Q3SZE9", "uniprot_id": "TBCC_BOVIN", "mass": { "chemical_mass": 38903.0, "monoisotopic_mass": 38903.0 }, "refseq": { "ac": "NP_001069177", "name": "tubulin-specific chaperone C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069177" }, "gene_names": [ { "name": "TBCC", "type": "recommended", "evidence": [ { "id": "Q3SZE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9" } ] }, { "name": "TBCC", "type": "synonym", "evidence": [ { "id": "NP_001069177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069177" } ] } ], "protein_names": [ { "name": "Tubulin-specific chaperone C", "type": "recommended", "evidence": [ { "id": "Q3SZE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9/entry#names_and_taxonomy" } ] }, { "name": "CFC", "type": "synonym", "evidence": [ { "id": "NP_001069177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069177" }, { "id": "Q3SZE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9/entry#names_and_taxonomy" } ] }, { "name": "Tubulin-folding cofactor C", "type": "synonym", "evidence": [ { "id": "Q3SZE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9/entry#names_and_taxonomy" } ] }, { "name": "beta-tubulin cofactor C", "type": "synonym", "evidence": [ { "id": "NP_001069177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069177" } ] }, { "name": "tubulin-specific chaperone C", "type": "synonym", "evidence": [ { "id": "NP_001069177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069177" } ] } ], "function": [ { "annotation": "Tubulin-folding protein; involved in the final step of the tubulin folding pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE9", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZE9", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBCC", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9", "locus": { "chromosome": "23", "start_pos": 16396466, "end_pos": 16400187, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000940", "url": "https://www.ensembl.org/id/ENSBTAG00000000940" } ] } } ], "crossref": [ { "id": "Q3SZE9", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZE9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000940", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000940", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515354", "url": "https://www.ncbi.nlm.nih.gov/gene/515354", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012945", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012945", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017901", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017901", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027684", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027684", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031925", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031925", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515354", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515354", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YFQHEIT", "url": "https://omabrowser.org/oma/group/YFQHEIT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZE9", "url": "https://www.orthodb.org/?gene=Q3SZE9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15139", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15139", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15139:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15139:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07986", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07986", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16752", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16752", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069177", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZE9", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZE9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METGGLSAAALANGDLGSQRERTLVPERLQKREHERQLEVERRKQKRQDQEVEEEKSDFFAAAFARERSAVEELLESGESVERLEEAAARLQGLQKLINDSVLFLAAYDLRQAQEVLARLQAALAKRRQELQPKKRFAFKTRKKDAASATQVASAPDAPAAEGSLTSPPPLKEEGDFDSSWICGFSNLQSQVLEKRAEELHQQDVLLTQLRNCTIKLYGNPNTLRLTKAQGCTLLCGPVSTSVFLEDCSDCVLAVACQQLRVHTTKDTRIFLQVTSRAIMEDCTGIQFAPYTWSYPGIDKDFEGSGLDKNKNNWNDVDDFNWLARDVASPNWNVLPEEERRIQWD", "length": 345, "header": "sp|Q3SZE9-1|TBCC_BOVIN Isoform 1 of Tubulin-specific chaperone C OS=Bos taurus OX=9913 GN=TBCC PE=2 SV=1 CANONICAL=Q3SZE9-1" }, "isoforms": [ { "isoform_ac": "Q3SZE9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9/entry#Q3SZE9-1", "sequence": { "sequence": "METGGLSAAALANGDLGSQRERTLVPERLQKREHERQLEVERRKQKRQDQEVEEEKSDFFAAAFARERSAVEELLESGESVERLEEAAARLQGLQKLINDSVLFLAAYDLRQAQEVLARLQAALAKRRQELQPKKRFAFKTRKKDAASATQVASAPDAPAAEGSLTSPPPLKEEGDFDSSWICGFSNLQSQVLEKRAEELHQQDVLLTQLRNCTIKLYGNPNTLRLTKAQGCTLLCGPVSTSVFLEDCSDCVLAVACQQLRVHTTKDTRIFLQVTSRAIMEDCTGIQFAPYTWSYPGIDKDFEGSGLDKNKNNWNDVDDFNWLARDVASPNWNVLPEEERRIQWD", "length": 345, "header": "sp|Q3SZE9-1|TBCC_BOVIN Isoform 1 of Tubulin-specific chaperone C OS=Bos taurus OX=9913 GN=TBCC PE=2 SV=1 CANONICAL=Q3SZE9-1" }, "locus": { "chromosome": "23", "start_pos": 16397777, "end_pos": 16397293, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132216.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132216.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082897.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082897.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 167, "end_pos": 167, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE9", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9" } ], "site_lbl": "Ser167" }, { "start_pos": 80, "end_pos": 80, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE9", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9" } ], "site_lbl": "Ser80" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515354", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515354", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z6M9-1", "protein_name": "Tubulin-specific chaperone C", "gene_name": "TBCC", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEATGEERRAPAAFVAALGPETGGTAAAALPERLQRREAERQRGVARQRELKEAQAVREEGSEFFAAAFGREREAVEALLAAGRPEEAAARLQGLQKLLTESVRFLAPYEVRQGQEAVSRLQADLAARRQQLQPKKKFAFRNLKKEAAPGAEPRPAEPEERAEPPAPGSAEGESGGPPLCGFSRAEGRELELGPAELLQHDVVLEELRGCQVRLRGNPNTLRVRECRGCTVLCGPVSTSVLVDGCSECQLVVACQQLRTHRTRGSRFYVQVTSRAVIEDCSEVSFAPYTWSYPGIEADFESSGLDRNSNNWNLVDDFDWLASDRPSPNWSLIPEEERVSCWD", "length": 342 }, "evidence": [ { "id": "Q3SZE9", "url": "https://omabrowser.org/oma/group/Q3SZE9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8W4FKF3-1", "protein_name": "Tubulin-specific chaperone C", "gene_name": "TBCC", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEDSSFSAAAAAVRNGDLGSQWDRSLVPERLQRREQERQLEVERRKQKRQNEEVEEEKSDFFAAAFARERSAVEELLEGGESVEKLEEAAARLQGLQKLINDSVLFLAAYDLRQGQEVLARLQAALAKRRQELQPKKRFAFKTRRKDIASATKVDSAPGAPAADGILASSPPLKEEGGFDSSWVCGFSNLQSEVLEKRADELHQRDVLLTQLSNCTIKLYGNPNTLRLTKARGCTLLCGPVSTSVFLEDCSDCVLAVACQQLRVHTTKDTRVFLLVTSRAIVEDCTGIQFAPYTWSYPGIDKDFEGSGLDRSKNNWNDVDDFNWLARDVASPNWSILPEEERRIQWD", "length": 347 }, "evidence": [ { "id": "Q3SZE9", "url": "https://omabrowser.org/oma/group/Q3SZE9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "B2GUZ7-1", "protein_name": "Tubulin-specific chaperone C", "gene_name": "Tbcc", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEGVDCSVALADAAAGSPRDLSLVPERLQRRKQKRQDQEVEEEKSGFFAAAFARERAAAEELLQGEASAERLEEAANRLQALRKLLNDSVLFLAAYDLRQGQAALAQLQSVLTERRQELQPKKRFAFKARKKDAAGTAQVDAAPVTSAAPSPPLTEEEGAPGASWACGFSNLESQDLEKRAEELHQRDILLSDLTNCTVRLRGNPNTLRLAKARGCKVLCGPVTTSVFLEDCRDCILAVACQQLRVHTTKDTRIFLQVTSRAIVEDCSGIQFAPYTWSYPGIDKDFQDSGLDRSKNNWNQVDDFNWLAQNVPSPNWSILPEEDRDIQWD", "length": 329 }, "evidence": [ { "id": "Q3SZE9", "url": "https://omabrowser.org/oma/group/Q3SZE9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1QJC8-1", "protein_name": "Tubulin-specific chaperone C", "gene_name": "tbcc", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAALGVEMNVAQDDGETNTAVKVPESVLRRDQARLEEAERRRDVKQSQTVTEEKSDFFTSTFNAEKTQLEEMISSCNDREKAAKTLEEATVKFQQLQKFLNDSVRFLTQYEIRQAQESLQKLQSSITDKREEILPKKKFAFRSRNTSKQQQPTPIQQQTADKPAPGSVGTVVVDAADQCGFSNVDNQVLVRQAEEIQQRDVLLSHLTHCKVRLYGCPSTLHIKNIRSCEIMCGPVSSSVFVDQCTDSTLVFPCQQLRTHNTTATRVYLHVTSRAIIEDCQGVSFAPFTWTYPGILDHFKVAGLSPDRNNWTEVDDFNWLAAGTPSPNWTVIPESERICSWDFVGTAAEQS", "length": 350 }, "evidence": [ { "id": "Q3SZE9", "url": "https://omabrowser.org/oma/group/Q3SZE9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q15814-1", "protein_name": "Tubulin-specific chaperone C", "gene_name": "TBCC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESVSCSAAAVRTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFVRERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRRGLQPKKRFAFKTRGKDAASSTKVDAAPGIPPAVESIQDSPLPKKAEGDLGPSWVCGFSNLESQVLEKRASELHQRDVLLTELSNCTVRLYGNPNTLRLTKAHSCKLLCGPVSTSVFLEDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVEDCSGIQFAPYTWSYPEIDKDFESSGLDRSKNNWNDVDDFNWLARDMASPNWSILPEEERNIQWD", "length": 346 }, "evidence": [ { "id": "Q3SZE9", "url": "https://omabrowser.org/oma/group/Q3SZE9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VCN9-1", "protein_name": "Tubulin-specific chaperone C", "gene_name": "Tbcc", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGVDCSMALADAAAGSPRDLSLVPERLQRREQERQIEVERRKQKRQDQEVEEEKSGFFAAAFARERAAVEELLRGEASAERLEEAANRLQGLRKLLNDSVLFLAAYDLRQGQAALAQLQAVLTERRQELQPKKRFAFKARKKDAAGTAQVDAAPVTSAAPSPPVTKEEEGAPGASWACGFSNLESQDLEKRAEELHQRDVLLSDLTNCTVKLCGNPNTLRLAKARGCKVLCGPVTTSVFLEDCRDCVLAVACQQLRVHTTKDTRVFLQVTSRAIVEDCSGIQFAPYTWSYPGIDKDFQDSGLDRSKNNWDQVDDFNWLARNVASPNWSILPEEERDIQWD", "length": 341 }, "evidence": [ { "id": "Q3SZE9", "url": "https://omabrowser.org/oma/group/Q3SZE9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9SMR2-1", "protein_name": "Tubulin-folding cofactor C", "gene_name": "TFCC", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEDDGQSSVAETLDPALQKKHHDMLERLSARHQARKSDSPDSSSSSSSTLESTSSFLAKFSDSKRSIESRIAESRLASSSTDSSKLKSDLAEISVAIDNLEKLLAENSYFLPSYEVRSSLKIVSDLKQSLDILSGELVPKKKFSFKSKSTTKKPESKLPEIQKPDVVLPPKLVPVRDSPGLRNKHGETLVKSFEGSSIGEFTLSDLDSCQVKLTGTVNALFLHRLKKCSVYTGPVIGSILIDDVEDCVLVLASHQIRIHCARKSDFYLRVRSRPIIEDSNGVRFAPYCLDYKGIDEDLKTAGLEEETNNWANVDDFRWLRAVQSPNWSLLPEEERVSLLTISGDS", "length": 345 }, "evidence": [ { "id": "Q3SZE9", "url": "https://omabrowser.org/oma/group/Q3SZE9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE9", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9" } ], "pmid": "" }, { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE9", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9" } ], "pmid": "" }, { "name": "tubulin binding", "id": "GO:0015631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015631", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE9", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE9", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE9", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9" } ], "pmid": "" }, { "name": "photoreceptor connecting cilium", "id": "GO:0032391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032391", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE9", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE9", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9" } ], "pmid": "" }, { "name": "tubulin complex assembly", "id": "GO:0007021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007021", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE9", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9" } ], "pmid": "" }, { "name": "post-chaperonin tubulin folding pathway", "id": "GO:0007023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007023", "evidence": [ { "database": "UniProtKB", "id": "Q3SZE9", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 212, "end_pos": 214, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZE9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 345, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZE9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZE9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SZE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZE9" }, { "id": "PRU00659", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00659" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C-CAP/cofactor C-like", "eco_id": "ECO_0000255", "start_pos": 170, "end_pos": 322, "start_aa": "Pro", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 80, 167 ], "sequon_annotation_sites": [ { "start_pos": 212, "end_pos": 214 }, { "start_pos": 99, "end_pos": 101 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { 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"kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZF2-1", "uniprot_ac": "Q3SZF2", "uniprot_id": "ARF4_BOVIN", "mass": { "chemical_mass": 20528.0, "monoisotopic_mass": 20528.0 }, "refseq": { "ac": "NP_001029702", "name": "ADP-ribosylation factor 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029702" }, "gene_names": [ { "name": "ARF4", "type": "recommended", "evidence": [ { "id": "Q3SZF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZF2" } ] }, { "name": "ARF4", "type": "synonym", "evidence": [ { "id": "NP_001029702", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029702" } ] } ], "protein_names": [ { "name": "ADP-ribosylation factor 4", "type": "recommended", "evidence": [ { "id": "Q3SZF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZF2/entry#names_and_taxonomy" } ] }, { "name": "ADP-ribosylation factor 4", "type": "synonym", "evidence": [ { "id": "NP_001029702", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029702" } ] } ], "function": [ { "annotation": "GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity). Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZF2", "url": "https://www.uniprot.org/uniprotkb/Q3SZF2#function" }, { "database": "UniProtKB", "id": "P18085", "url": "https://www.uniprot.org/uniprotkb/P18085#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZF2", "url": "https://www.uniprot.org/uniprotkb/Q3SZF2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARF4", "url": "https://www.uniprot.org/uniprotkb/Q3SZF2", "locus": { "chromosome": "22", "start_pos": 43625327, "end_pos": 43606541, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016069", "url": "https://www.ensembl.org/id/ENSBTAG00000016069" } ] } } ], "crossref": [ { "id": "Q3SZF2", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZF2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016069", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016069", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04150", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04150", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "518601", "url": "https://www.ncbi.nlm.nih.gov/gene/518601", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006689", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006689", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518601", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518601", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DWLCNEL", "url": "https://omabrowser.org/oma/group/DWLCNEL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZF2", "url": "https://www.orthodb.org/?gene=Q3SZF2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11711", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11711", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00025", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00025", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5620916", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620916", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6807878", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811434", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811434", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029702", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZF2", "url": "https://www.uniprot.org/uniprotkb/Q3SZF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZF2-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZF2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLTISSLFSRLFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNICFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERIQEGAEELQKMLQEDELRDAVLLLFANKQDLPNAMAISEMTDKLGLQSLRNRTWYVQATCATQGTGLYEGLDWLSNELSKR", "length": 180, "header": "sp|Q3SZF2-1|ARF4_BOVIN Isoform 1 of ADP-ribosylation factor 4 OS=Bos taurus OX=9913 GN=ARF4 PE=2 SV=3 CANONICAL=Q3SZF2-1" }, "isoforms": [ { "isoform_ac": "Q3SZF2-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZF2/entry#Q3SZF2-1", "sequence": { "sequence": "MGLTISSLFSRLFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNICFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERIQEGAEELQKMLQEDELRDAVLLLFANKQDLPNAMAISEMTDKLGLQSLRNRTWYVQATCATQGTGLYEGLDWLSNELSKR", "length": 180, "header": "sp|Q3SZF2-1|ARF4_BOVIN Isoform 1 of ADP-ribosylation factor 4 OS=Bos taurus OX=9913 GN=ARF4 PE=2 SV=3 CANONICAL=Q3SZF2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 147, "end_pos": 147, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZF2", "url": "https://www.uniprot.org/uniprotkb/Q3SZF2" } ], "site_lbl": "Ser147" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518601", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518601", "resource": "KEGG Pathway" }, { "id": "R-BTA-5620916", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620916", "resource": "Reactome", "description": "VxPx cargo-targeting to cilium" }, { "id": "R-BTA-6807878", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "resource": "Reactome", "description": "COPI-mediated anterograde transport" }, { "id": "R-BTA-6811434", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811434", "resource": "Reactome", "description": "COPI-dependent Golgi-to-ER retrograde traffic" } ], "orthologs": [ { "uniprot_canonical_ac": "G3GUS2-1", "protein_name": "ADP-ribosylation factor", "gene_name": "Arf4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGLTISSLFSRLFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNICFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERIQEGAAVLQKMLLEDELQDAVLLLFANKQDLPNAMAISEMTDKLGLQSLRNRTWYVQATCATQGTGLYEGLDWLSNELSKR", "length": 180 }, "evidence": [ { "id": "Q3SZF2", "url": "https://omabrowser.org/oma/group/Q3SZF2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P18085-1", "protein_name": "ADP-ribosylation factor 4", "gene_name": "ARF4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGLTISSLFSRLFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNICFTVWDVGGQDRIRPLWKHYFQNTQGLIFVVDSNDRERIQEVADELQKMLLVDELRDAVLLLFANKQDLPNAMAISEMTDKLGLQSLRNRTWYVQATCATQGTGLYEGLDWLSNELSKR", "length": 180 }, "evidence": [ { "id": "Q3SZF2", "url": "https://omabrowser.org/oma/group/Q3SZF2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P40945-1", "protein_name": "ADP ribosylation factor 4", "gene_name": "Arf4", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGLTISSLLTRLFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNICFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRDRITEAERELQNMLQEDELRDAVLLVFANKQDLPNAMTAAELTDKLRLNQLRNRHWFIQSTCATQGHGLYEGLDWLSAELAKK", "length": 180 }, "evidence": [ { "id": "Q3SZF2", "url": "https://omabrowser.org/oma/group/Q3SZF2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P61750-1", "protein_name": "ADP-ribosylation factor 4", "gene_name": "Arf4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLTISSLFSRLFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNICFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERIQEGAAVLQKMLLEDELQDAVLLLFANKQDLPNAMAISEMTDKLGLQSLRNRTWYVQATCATQGTGLYEGLDWLSNELSKR", "length": 180 }, "evidence": [ { "id": "Q3SZF2", "url": "https://omabrowser.org/oma/group/Q3SZF2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P61751-1", "protein_name": "ADP-ribosylation factor 4", "gene_name": "Arf4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGLTISSLFSRLFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNICFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERIQEGAAVLQKMLLEDELQDAVLLLFANKQDLPNAMAISEMTDKLGLQSLRNRTWYVQATCATQGTGLYEGLDWLSNELSKR", "length": 180 }, "evidence": [ { "id": "Q3SZF2", "url": "https://omabrowser.org/oma/group/Q3SZF2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6P5M5-1", "protein_name": "ADP-ribosylation factor", "gene_name": "wu:fi36f11", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGLTISSLFSRLFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNICFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVAESAEELSKMLQEDELRDAVLLVFANKQDLPNAMAVSELTDKLGLQSLRSRTWYVQATCATQGTGLYEGLDWLSNELSKR", "length": 180 }, "evidence": [ { "id": "Q3SZF2", "url": "https://omabrowser.org/oma/group/Q3SZF2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q3SZF2", "url": "https://www.uniprot.org/uniprotkb/Q3SZF2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SZF2", "url": "https://www.uniprot.org/uniprotkb/Q3SZF2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3SZF2", "url": "https://www.uniprot.org/uniprotkb/Q3SZF2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "Q3SZF2", "url": "https://www.uniprot.org/uniprotkb/Q3SZF2" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q3SZF2", "url": "https://www.uniprot.org/uniprotkb/Q3SZF2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "Q3SZF2", "url": "https://www.uniprot.org/uniprotkb/Q3SZF2" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "Q3SZF2", "url": "https://www.uniprot.org/uniprotkb/Q3SZF2" } ], "pmid": "" }, { "name": "regulation of cilium assembly", "id": "GO:1902017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902017", "evidence": [ { "database": "UniProtKB", "id": "Q3SZF2", "url": "https://www.uniprot.org/uniprotkb/Q3SZF2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 150, "end_pos": 152, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZF2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 180, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": 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"Q3SZF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZF3/entry#names_and_taxonomy" } ] }, { "name": "heterogeneous nuclear ribonucleoprotein H'", "type": "synonym", "evidence": [ { "id": "NP_001069476", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069476" } ] }, { "name": "heterogeneous nuclear ribonucleoprotein H2 (H')", "type": "synonym", "evidence": [ { "id": "NP_001069476", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069476" } ] }, { "name": "heterogeneous nuclear ribonucleoprotein H2", "type": "synonym", "evidence": [ { "id": "NP_001069476", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069476" } ] }, { "name": "hnRNP H'", "type": "synonym", "evidence": [ { "id": "NP_001069476", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069476" }, { "id": "Q3SZF3", "database": "UniProtKB", "url": 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"Q3SZG8", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZG8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000053156", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000053156", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514652", "url": "https://www.ncbi.nlm.nih.gov/gene/514652", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016092", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016092", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514652", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514652", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LYIYGMQ", "url": "https://omabrowser.org/oma/group/LYIYGMQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZG8", "url": "https://www.orthodb.org/?gene=Q3SZG8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10072", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10072", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10072:SF41", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10072:SF41", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01521", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01521", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1362409", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1362409", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9854311", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9854311", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029642", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZG8", "url": "https://www.uniprot.org/uniprotkb/Q3SZG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZG8-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZG8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSASLVRATVRAVSKRKLQPTRAALTLTPSAVNKIKQLLKDKPEHVGVKVGVRTRGCNGLSYTLEYTKTKGDSDEEVIQDGVRVFIEKKAQLTLLGTEMDYVEDKLSSEFVFNNPNIKGTCGCGESFNI", "length": 129, "header": "sp|Q3SZG8-1|ISCA1_BOVIN Isoform 1 of Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Bos taurus OX=9913 GN=ISCA1 PE=2 SV=1 CANONICAL=Q3SZG8-1" }, "isoforms": [ { "isoform_ac": "Q3SZG8-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZG8/entry#Q3SZG8-1", "sequence": { "sequence": "MSASLVRATVRAVSKRKLQPTRAALTLTPSAVNKIKQLLKDKPEHVGVKVGVRTRGCNGLSYTLEYTKTKGDSDEEVIQDGVRVFIEKKAQLTLLGTEMDYVEDKLSSEFVFNNPNIKGTCGCGESFNI", "length": 129, "header": "sp|Q3SZG8-1|ISCA1_BOVIN Isoform 1 of Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Bos taurus OX=9913 GN=ISCA1 PE=2 SV=1 CANONICAL=Q3SZG8-1" }, "locus": { "chromosome": "8", "start_pos": 79458904, "end_pos": 79447742, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079550.1", "url": "https://www.ensembl.org/id/ENSBTAT00000079550.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060430.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060430.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514652", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514652", "resource": "KEGG Pathway" }, { "id": "R-BTA-1362409", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1362409", "resource": "Reactome", "description": "Mitochondrial iron-sulfur cluster biogenesis" }, { "id": "R-BTA-9854311", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9854311", "resource": "Reactome", "description": "Maturation of TCA enzymes and regulation of TCA cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "Q4QRC6-1", "protein_name": "Iron-sulfur cluster assembly 1 homolog, mitochondrial", "gene_name": "isca1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSASIARATVRAVSRRKILSTRAALTLTPSAVNKVKQLLDNKPEYIGLKVGVRTRGCNGLTYTLDYTKNKEQSDEEVLQDGVRVFIEKKAQLTLLGTEMDFVETKLSSEFVFNNPNIKGTCGCGESFNI", "length": 129 }, "evidence": [ { "id": "Q3SZG8", "url": "https://omabrowser.org/oma/group/Q3SZG8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q54VS1-1", "protein_name": "Iron-sulfur cluster assembly 1 homolog, mitochondrial", "gene_name": "isca1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSISGVVKLGKPSKKAIFSMTDSALKRVKEIMNDKKIDNCIGLRLGIKERGCSGMSYTLDFATQKNKFDETVVADKDINIIVDSKALLSVIGTEMDYIEEPIKKEFIFINPNATNTCGCGESFTTKDFSIPDLKLPKKN", "length": 139 }, "evidence": [ { "id": "Q3SZG8", "url": "https://omabrowser.org/oma/group/Q3SZG8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5ZJ74-1", "protein_name": "Iron-sulfur cluster assembly 1 homolog, mitochondrial", "gene_name": "ISCA1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASSVVRATVRAVSKRKIQATRAALTLTPSAVQKIKQLLKDQPEHVGVKVGVRTRGCNGLSYTLEYTKSKGDSDEEVVQDGVRVFIEKKAQLTLLGTEMDYVEDKLSSEFVFNNPNIKGTCGCGESFNI", "length": 129 }, "evidence": [ { "id": "Q3SZG8", "url": "https://omabrowser.org/oma/group/Q3SZG8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q80W96-1", "protein_name": "Iron-sulfur cluster assembly 1 homolog, mitochondrial", "gene_name": "Isca1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSASLVRATVRAVSKRKLQPTRAALTLTPSAVNKIKQLLKDKPEHVGLKVGVRTRGCNGLSYSLEYTKTKGDADEEVIQDGVRVFIEKKAQLTLLGTEMDYVEDKLSSEFVFNNPNIKGTCGCGESFNV", "length": 129 }, "evidence": [ { "id": "Q3SZG8", "url": "https://omabrowser.org/oma/group/Q3SZG8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8LBM4-1", "protein_name": "Iron-sulfur assembly protein IscA-like 1, mitochondrial", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis 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"ENSBTAG00000002108", "url": "https://www.ensembl.org/id/ENSBTAG00000002108" } ] } } ], "crossref": [ { "id": "Q3SZI4", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZI4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002108", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002108", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10023", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10023", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "768311", "url": "https://www.ncbi.nlm.nih.gov/gene/768311", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "6BCY", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6BCY&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "6BD1", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6BD1&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR000308", "url": 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}, { "id": "Q3SZI4", "url": "https://www.orthodb.org/?gene=Q3SZI4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18860", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18860", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00006bcy", "url": "https://www.rcsb.org/structure/pdb_00006bcy", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00006bd1", "url": "https://www.rcsb.org/structure/pdb_00006bd1", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6BCY", "url": "https://www.rcsb.org/structure/6BCY", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6BD1", "url": "https://www.rcsb.org/structure/6BD1", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00244", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00244", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-111447", "url": 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"Protein" ] }, { "id": "A0ABI0NYW2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYW2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P5P0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5P0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P5P0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5P0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZI4", "url": "https://www.uniprot.org/uniprotkb/Q3SZI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZI4-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZI4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECDAAEGAEN", "length": 245, "header": "sp|Q3SZI4-1|1433T_BOVIN Isoform 1 of 14-3-3 protein theta OS=Bos taurus OX=9913 GN=YWHAQ PE=1 SV=1 CANONICAL=Q3SZI4-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NYW2-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZI4/entry#A0ABI0NYW2-1", "sequence": { "sequence": "MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTVSVPLFLICISCLGTKVSISIQALCLPGKLQ", "length": 257, "header": "tr|A0ABI0NYW2-1|A0ABI0NYW2_BOVIN Computationally mapped isoform of 14-3-3 protein theta OS=Bos taurus OX=9913 GN=YWHAQ PE=1 SV=1 CANONICAL=Q3SZI4-1" }, "locus": { "chromosome": "11", "start_pos": 87891245, "end_pos": 87862644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151067.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151067.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105554.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105554.1" } ] } }, { "isoform_ac": "A0ABI0P5P0-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZI4/entry#A0ABI0P5P0-1", "sequence": { "sequence": "MEKTELIQKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECDAAEGAEN", "length": 227, "header": "tr|A0ABI0P5P0-1|A0ABI0P5P0_BOVIN Computationally mapped isoform of Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta OS=Bos taurus OX=9913 GN=YWHAQ PE=1 SV=1 CANONICAL=Q3SZI4-1" }, "locus": { "chromosome": "11", "start_pos": 87892151, "end_pos": 87862644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000144884.1", "url": "https://www.ensembl.org/id/ENSBTAT00000144884.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106516.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106516.1" } ] } }, { "isoform_ac": "Q3SZI4-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZI4/entry#Q3SZI4-1", "sequence": { "sequence": "MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECDAAEGAEN", "length": 245, "header": "sp|Q3SZI4-1|1433T_BOVIN Isoform 1 of 14-3-3 protein theta OS=Bos taurus OX=9913 GN=YWHAQ PE=1 SV=1 CANONICAL=Q3SZI4-1" }, "locus": { "chromosome": "11", "start_pos": 87892151, "end_pos": 87862644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032851.4", "url": "https://www.ensembl.org/id/ENSBTAT00000032851.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032779.2", "url": "https://www.ensembl.org/id/ENSBTAP00000032779.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 232, "end_pos": 232, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CK1", "evidence": [ { "database": "UniProtKB", "id": "Q3SZI4", "url": "https://www.uniprot.org/uniprotkb/Q3SZI4" } ], "site_lbl": "Ser232" }, { "start_pos": 92, "end_pos": 92, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZI4", "url": "https://www.uniprot.org/uniprotkb/Q3SZI4" } ], "site_lbl": "Ser92" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q3SZI4", "url": "https://www.uniprot.org/uniprotkb/Q3SZI4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:768311", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:768311", "resource": "KEGG Pathway" }, { "id": "R-BTA-111447", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-111447", "resource": "Reactome", "description": "Activation of BAD and translocation to mitochondria" }, { "id": "R-BTA-5625740", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5625740", "resource": "Reactome", "description": "RHO GTPases activate PKNs" }, { "id": "R-BTA-5628897", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5628897", "resource": "Reactome", "description": "TP53 Regulates Metabolic Genes" }, { "id": "R-BTA-75035", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75035", "resource": "Reactome", "description": "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex" }, { "id": "R-BTA-9614399", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9614399", "resource": "Reactome", "description": "Regulation of localization of FOXO transcription factors" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QM17-1", "protein_name": "Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta", "gene_name": "YWHAQ", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKHNSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTVSFSFFQFYFLFRNKTISVLFRLFMYSFLVGIQKY", "length": 258 }, "evidence": [ { "id": "Q3SZI4", "url": "https://omabrowser.org/oma/group/Q3SZI4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P27348-1", "protein_name": "14-3-3 protein theta", "gene_name": "YWHAQ", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECDAAEGAEN", "length": 245 }, "evidence": [ { "id": "Q3SZI4", "url": "https://omabrowser.org/oma/group/Q3SZI4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P68254-1", "protein_name": "14-3-3 protein theta", "gene_name": "Ywhaq", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIENSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECDAAEGAEN", "length": 245 }, "evidence": [ { "id": "Q3SZI4", "url": 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"MDKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKMQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIENSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECDAAEGAEN", "length": 245 }, "evidence": [ { "id": "Q3SZI4", "url": "https://omabrowser.org/oma/group/Q3SZI4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SZI4", "url": "https://www.uniprot.org/uniprotkb/Q3SZI4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q3SZI4", "url": 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"table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3SZJ9-1", "uniprot_ac": "Q3SZJ9", "uniprot_id": "PMM2_BOVIN", "mass": { "chemical_mass": 27997.0, "monoisotopic_mass": 27997.0 }, "refseq": { "ac": "NP_001030267", "name": "phosphomannomutase 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030267" }, "gene_names": [ { "name": "PMM2", "type": "recommended", "evidence": [ { "id": "Q3SZJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9" } ] }, { "name": "PMM2", "type": "synonym", "evidence": [ { "id": "NP_001030267", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030267" } ] } ], "protein_names": [ { "name": "Phosphomannomutase 2", "type": "recommended", "evidence": [ { "id": "Q3SZJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9/entry#names_and_taxonomy" } ] }, { "name": "5.4.2.8", "type": "synonym", "evidence": [ { "id": "Q3SZJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9/entry#names_and_taxonomy" } ] }, { "name": "PMM 2", "type": "synonym", "evidence": [ { "id": "NP_001030267", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030267" }, { "id": "Q3SZJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9/entry#names_and_taxonomy" } ] }, { "name": "phosphomannomutase 2", "type": "synonym", "evidence": [ { "id": "NP_001030267", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030267" } ] } ], "function": [ { "annotation": "Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ9", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9#function" } ] }, { "annotation": "PMM2 and NARFL are paternally imprinted genes in bovines.", "evidence": 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"categories": [] }, { "id": "ENSBTAG00000001440", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001440", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02585", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02585", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510978", "url": "https://www.ncbi.nlm.nih.gov/gene/510978", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005002", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005002", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006379", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006379", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036412", "database": 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"https://www.ebi.ac.uk/interpro/entry/pfam/PF03332", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-446205", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-446205", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030267", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11140", "url": "https://www.rhea-db.org/rhea/11140", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZJ9", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZJ9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPGPALCLFDVDGTLTAPRQKITKDMDCFLQKLRQKIKIGVVGGSDFEKVQEQLGDDVIKKYDYVFPENGLVAYRDGKLLCKQNIQGHLGEALIQDLINYCLSYIAKIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDQKENIRQKFVEDLRKEFAGKGLTFSIGGQISFDVFPDGWDKRYCLGHVEKDGYKTIYFFGDKTMPGGNDHEIFTDPRTVGYTVAAPEDTRRICEELFC", "length": 246, "header": "sp|Q3SZJ9-1|PMM2_BOVIN Isoform 1 of Phosphomannomutase 2 OS=Bos taurus OX=9913 GN=PMM2 PE=2 SV=1 CANONICAL=Q3SZJ9-1" }, "isoforms": [ { "isoform_ac": "Q3SZJ9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9/entry#Q3SZJ9-1", "sequence": { "sequence": "MAAPGPALCLFDVDGTLTAPRQKITKDMDCFLQKLRQKIKIGVVGGSDFEKVQEQLGDDVIKKYDYVFPENGLVAYRDGKLLCKQNIQGHLGEALIQDLINYCLSYIAKIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDQKENIRQKFVEDLRKEFAGKGLTFSIGGQISFDVFPDGWDKRYCLGHVEKDGYKTIYFFGDKTMPGGNDHEIFTDPRTVGYTVAAPEDTRRICEELFC", "length": 246, "header": "sp|Q3SZJ9-1|PMM2_BOVIN Isoform 1 of Phosphomannomutase 2 OS=Bos taurus OX=9913 GN=PMM2 PE=2 SV=1 CANONICAL=Q3SZJ9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "PMM2 and NARFL are paternally imprinted genes in bovines.", "journal": "Animal genetics", "date": "2022-10", "authors": "Dong Yanqiu, Zhang Cui, Jin Lanjie, Li Dongjie, Chen Weina, Huo Haonan, Li Shijie", "evidence": [ { "database": "RefSeq", "id": "NP_001030267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030267" } ], "reference": [ { "type": "PubMed", "id": "36067531", "url": "https://glygen.org/publication/PubMed/36067531" } ] } ], "pathway": [ { "id": "bta:510978", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510978", "resource": "KEGG Pathway" }, { "id": "R-BTA-446205", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-446205", "resource": "Reactome", "description": "Synthesis of GDP-mannose" } ], "orthologs": [ { "uniprot_canonical_ac": "F7F1X7-1", "protein_name": "Phosphomannomutase", "gene_name": "Pmm2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATLCLFDMDGTLTAPRQKITKEMDGFLQKLRQKTKIGVVGGSDFEKLQEQLGNDVVEKYDYVFPENGLVAYKDGKLLCKQNIQGHLGEAVIQDLINYCLSYIAKIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDKKEHIRQKFVADLRKEFAGKGLTFSIGGQISFDVFPDGWDKRYCLRHLEQAGYKTIYFFGDKTMPGGNDHEIFTDPRTVGYTVTAPEDTRRICEELFP", "length": 242 }, "evidence": [ { "id": "Q3SZJ9", "url": "https://omabrowser.org/oma/group/Q3SZJ9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3GVN0-1", "protein_name": "Phosphomannomutase", "gene_name": "Pmm2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAALCLFDVDGTLTAPRQKITKEMDDFLQKLRQKTKIGVVGGSDFEKVQEQLGNDVVEKYDYVFPENGLVAYKDGKLLCKQSIQGHLGEAVIQDLINYCLSYIAKIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDKKENIRQKFVADLKKEFAGKGLTFSIGGQISFDVFPDGWDKRYCLKHLEHDGYKTIYFFGDKTMPGGNDHEIFTDPRTVGYTVTAPEDTRRICEELFH", "length": 242 }, "evidence": [ { "id": "Q3SZJ9", "url": "https://omabrowser.org/oma/group/Q3SZJ9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O15305-1", "protein_name": "Phosphomannomutase 2", "gene_name": "PMM2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAPGPALCLFDVDGTLTAPRQKITKEMDDFLQKLRQKIKIGVVGGSDFEKVQEQLGNDVVEKYDYVFPENGLVAYKDGKLLCRQNIQSHLGEALIQDLINYCLSYIAKIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDKKENIRQKFVADLRKEFAGKGLTFSIGGQISFDVFPDGWDKRYCLRHVENDGYKTIYFFGDKTMPGGNDHEIFTDPRTMGYSVTAPEDTRRICELLFS", "length": 246 }, "evidence": [ { "id": "Q3SZJ9", "url": "https://omabrowser.org/oma/group/Q3SZJ9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O80840-1", "protein_name": "Phosphomannomutase", "gene_name": "PMM", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAAKIPGVIALFDVDGTLTAPRKEATPELLDFIRELRKVVTIGVVGGSDLSKISEQLGKTVTNDYDYCFSENGLVAHKDGKSIGIQSLKLHLGDDKLKELINFTLHYIADLDIPIKRGTFIEFRNGMLNVSPIGRNCSQEERDEFERYDKVQNIRPKMVAELRERFAHLNLTFSIGGQISFDVFPKGWDKTYCLQYLEDFSEIHFFGDKTYEGGNDYEIYESPKTIGHSVTSPDDTVAKCKALFMS", "length": 246 }, "evidence": [ { "id": "Q3SZJ9", "url": "https://omabrowser.org/oma/group/Q3SZJ9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P07283-1", "protein_name": "Phosphomannomutase", "gene_name": "SEC53", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSIAEFAYKEKPETLVLFDVDGTLTPARLTVSEEVRKTLAKLRNKCCIGFVGGSDLSKQLEQLGPNVLDEFDYSFSENGLTAYRLGKELASQSFINWLGEEKYNKLAVFILRYLSEIDLPKRRGTFLEFRNGMINVSPIGRNASTEERNEFERYDKEHQIRAKFVEALKKEFPDYGLTFSIGGQISFDVFPAGWDKTYCLQHVEKDGFKEIHFFGDKTMVGGNDYEIFVDERTIGHSVQSPDDTVKILTELFNL", "length": 254 }, "evidence": [ { "id": "Q3SZJ9", "url": "https://omabrowser.org/oma/group/Q3SZJ9/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54X03-1", "protein_name": "Phosphomannomutase 1", "gene_name": "pmmA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSLVPNTICLFDVDGTLTKPRNVITPEMKDFLAGLRTKVELGVVGGSDINKIKEQLGENCINEFHYLFAENGLLSFKDGSLLATQDIKKFLGEENIKKFINFVLHYIADLDIPIKRGTFVEFRNGMINISPIGRNCSQQEREEFEKYDLEHKIRPTMVSILKEKFQSLGLQYSIGGQISFDVFPIGWDKTYCLRHLPEDKYKTIYFFGDKTFVGGNDYEIANDPRITKSFTVTSPTDTKNFLSELFYKQ", "length": 249 }, "evidence": [ { "id": "Q3SZJ9", "url": "https://omabrowser.org/oma/group/Q3SZJ9/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9VTZ6-1", "protein_name": "Phosphomannomutase", "gene_name": "Pmm2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTTAALKRDEILLLFDVDGTLTMPRSVVTPEFEEFFYSRVKPRATIGIVGGSDLEKMFEQLNGRKILNEFDFIFPENGLVQIEGGKEVGKQNIIMHLGEETVKRFINFVLRYLSELDVPIKRGTFIEFRNGMMNVCPIGRQCTREERNMFAEYDIEHKVREKMIKDLKQEFADVDLTYSIGGQISFDVFPHGWDKTYCLRHIEAHYKFKEIHFFGDKTEPGGNDYEIYSDPRTISHRVYTPKDTQRILTEILEL", "length": 254 }, "evidence": [ { "id": "Q3SZJ9", "url": "https://omabrowser.org/oma/group/Q3SZJ9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Z2M7-1", "protein_name": "Phosphomannomutase 2", "gene_name": "Pmm2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATLCLFDMDGTLTAPRQKITEEMDGFLQKLRQKTKIGVVGGSDFEKLQEQLGNDVVEKYDYVFPENGLVAYKDGKLLCKQNIQGHLGEDVIQDLINYCLSYIANIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDKKEHIRQKFVADLRKEFAGKGLTFSIGGQISIDVFPEGWDKRYCLRHLEHAGYKTIYFFGDKTMPGGNDHEIFTDPRTVGYTVTAPEDTRRICEGLFP", "length": 242 }, "evidence": [ { "id": "Q3SZJ9", "url": "https://omabrowser.org/oma/group/Q3SZJ9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ9", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ9", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9" } ], "pmid": "" }, { "name": "phosphomannomutase activity", "id": "GO:0004615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004615", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ9", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein N-linked glycosylation", "id": "GO:0006487", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006487", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ9", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9" } ], "pmid": "" }, { "name": "mannose metabolic process", "id": "GO:0006013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006013", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ9", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9" } ], "pmid": "" }, { "name": "GDP-mannose biosynthetic process from mannose", "id": "GO:0061728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061728", "evidence": [ { "database": "UniProtKB", "id": "Q3SZJ9", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11140", "name": "", "equation": "alpha-D-mannose 1-phosphate = D-mannose 6-phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T0Z0-1", "Q3SZJ9-1", "A0ABI0NIM0-1" ], "evidence": [ { "id": "11140", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11140" } ] }, { "id": "R-BTA-446201", "name": "PMM1,2 isomerise Man6P to Man1P", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-532562" ], "output_participant_list": [], "enzyme_list": [ "Q3SZJ9-1" ], "evidence": [ { "id": "R-BTA-446201", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-446201" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-532562", "participant_name": "Man6P [cytosol]", "crossref": [ { "id": "58735", "database": "ChEBI", "url": "" }, { "id": "ZINC000004096188", "database": "ZINC", "url": "" }, { "id": "ZINC000003869397", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9T0Z0", "gene_name": "PMM2", "activity": [ { "ec_number": "5.4.2.8", "activity": "alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.", "evidence": [ { "id": "A0AAA9T0Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Z0" } ] }, { "ec_number": "5.4.2.8", "activity": "", "evidence": [ { "id": "A0AAA9T0Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Z0" } ] } ] }, { "uniprot_ac": "A0ABI0NIM0", "gene_name": "LOC782057", "activity": [ { "ec_number": "5.4.2.8", "activity": "alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.", "evidence": [ { "id": "A0ABI0NIM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NIM0" } ] }, { "ec_number": "5.4.2.8", "activity": "", "evidence": [ { "id": "A0ABI0NIM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NIM0" } ] } ] }, { "uniprot_ac": "Q3SZJ9", "gene_name": "PMM2", "activity": [ { "ec_number": "5.4.2.8", "activity": "alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.", "evidence": [ { "id": "Q3SZJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9" } ] }, { "ec_number": "5.4.2.8", "activity": "", "evidence": [ { "id": "Q3SZJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZJ9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 246, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZJ9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZJ9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q3SZJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9#function" }, { "id": "Q3SZJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9" } ], "binding_site_uniprot": 12, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 12, "end_pos": 12, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9#function" }, { "id": "Q3SZJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9" } ], "binding_site_uniprot": 14, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 14, "end_pos": 14, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9#function" }, { "id": "Q3SZJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9" } ], "binding_site_uniprot": 209, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 209, "end_pos": 209, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9#function" }, { "id": "Q3SZJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9" } ], "binding_site_uniprot": 221, "amino_acid": "Phe", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 221, "end_pos": 221, "start_aa": "Phe", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9#function" }, { "id": "Q3SZJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9" } ], "binding_site_uniprot": 223, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 223, "end_pos": 223, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9#function" }, { "id": "Q3SZJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ9" } ], "binding_site_uniprot": 226, "amino_acid": "Thr", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 226, "end_pos": 226, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "5.4.2.8", "ec_name": "alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.", "evidence": [ { "id": "5.4.2.8", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.8" }, { "id": "5.4.2.8", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=5.4.2.8" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 128, "end_pos": 130 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3SZK1-1", "uniprot_ac": "Q3SZK1", "uniprot_id": "AAMP_BOVIN", "mass": { "chemical_mass": 46829.0, "monoisotopic_mass": 46829.0 }, "refseq": { "ac": "NP_001070463", "name": "angio-associated migratory cell protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070463" }, "gene_names": [ { "name": "AAMP", "type": "recommended", "evidence": [ { "id": "Q3SZK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZK1" } ] }, { "name": "AAMP", "type": "synonym", "evidence": [ { "id": "NP_001070463", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070463" } ] } ], "protein_names": [ { "name": "Angio-associated migratory cell protein", "type": "recommended", "evidence": [ { "id": "Q3SZK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZK1/entry#names_and_taxonomy" } ] }, { "name": "angio-associated migratory cell protein", "type": "synonym", "evidence": [ { "id": "NP_001070463", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070463" } ] } ], "function": [ { "annotation": "Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK1", "url": "https://www.uniprot.org/uniprotkb/Q3SZK1#function" }, { "database": "PubMed", "id": "11969303", "url": "https://glygen.org/publication/PubMed/11969303" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZK1", "url": "https://www.uniprot.org/uniprotkb/Q3SZK1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AAMP", "url": "https://www.uniprot.org/uniprotkb/Q3SZK1", "locus": { "chromosome": "2", "start_pos": 106293608, "end_pos": 106301156, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003927", "url": "https://www.ensembl.org/id/ENSBTAG00000003927" } ] } } ], "crossref": [ { "id": "Q3SZK1", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZK1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003927", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003927", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "767919", "url": "https://www.ncbi.nlm.nih.gov/gene/767919", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056551", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056551", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767919", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767919", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GPDEVMW", "url": "https://omabrowser.org/oma/group/GPDEVMW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZK1", "url": "https://www.orthodb.org/?gene=Q3SZK1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19857", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19857", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19857:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19857:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23098", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23098", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-168638", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-168638", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-177929", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-177929", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-428930", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-428930", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001070463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070463", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZK1", "url": "https://www.uniprot.org/uniprotkb/Q3SZK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZK1-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZK1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESESESGAAADTPPLETLSFHGDEEIIEVVELDPGPPDPDDLVQEMEDVDFEEEEEEEGNEEGWVLEPQEGVVGSMEGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPTGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGNSIHVLKGTEGHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLSTQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQRPDR", "length": 434, "header": "sp|Q3SZK1-1|AAMP_BOVIN Isoform 1 of Angio-associated migratory cell protein OS=Bos taurus OX=9913 GN=AAMP PE=2 SV=1 CANONICAL=Q3SZK1-1" }, "isoforms": [ { "isoform_ac": "Q3SZK1-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZK1/entry#Q3SZK1-1", "sequence": { "sequence": "MESESESGAAADTPPLETLSFHGDEEIIEVVELDPGPPDPDDLVQEMEDVDFEEEEEEEGNEEGWVLEPQEGVVGSMEGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPTGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGNSIHVLKGTEGHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLSTQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQRPDR", "length": 434, "header": "sp|Q3SZK1-1|AAMP_BOVIN Isoform 1 of Angio-associated migratory cell protein OS=Bos taurus OX=9913 GN=AAMP PE=2 SV=1 CANONICAL=Q3SZK1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 20, "end_pos": 20, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK1", "url": "https://www.uniprot.org/uniprotkb/Q3SZK1" } ], "site_lbl": "Ser20" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Extracellular angio-associated migratory cell protein plays a positive role in angiogenesis and is regulated by astrocytes in coculture.", "journal": "Microvascular research", "date": "2002-05", "authors": "Beckner Marie E, Jagannathan Syamala, Peterson Virginia A", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK1", "url": "https://www.uniprot.org/uniprotkb/Q3SZK1" } ], "reference": [ { "type": "PubMed", "id": "11969303", "url": "https://glygen.org/publication/PubMed/11969303" } ] } ], "pathway": [ { "id": "bta:767919", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767919", "resource": "KEGG Pathway" }, { "id": "R-BTA-168638", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-168638", "resource": "Reactome", "description": "NOD1/2 Signaling Pathway" }, { "id": "R-BTA-177929", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-177929", "resource": "Reactome", "description": "Signaling by EGFR" }, { "id": "R-BTA-428930", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-428930", "resource": "Reactome", "description": "Thromboxane signalling through TP receptor" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABB5UNU5-1", "protein_name": "Angio-associated migratory cell protein", "gene_name": "AAMP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MESESESGAAADTPLETLSFHGDEEIIEVVELDPGPPDPADDLAQEMEDVDFEEEEEEEGNEEGWVLEPQEGVVGSMEGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGNAIYVLKGTEGHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPNLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLSTQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQRPDR", "length": 434 }, "evidence": [ { "id": "Q3SZK1", "url": "https://omabrowser.org/oma/group/Q3SZK1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3V7V2-1", "protein_name": "Angio-associated migratory cell protein", "gene_name": "Aamp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MESESESGAAADTPPLETLSFHGDEEIIEVVELDPGPPDPDDLAQEMEDVDFEEEEEEEEGNDEGWVLEPQEGVVGSMEGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVETKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGNPIHVLKGTEGHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLSTQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGVVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQRPDR", "length": 435 }, "evidence": [ { "id": "Q3SZK1", "url": "https://omabrowser.org/oma/group/Q3SZK1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q13685-1", "protein_name": "Angio-associated migratory cell protein", "gene_name": "AAMP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESESESGAAADTPPLETLSFHGDEEIIEVVELDPGPPDPDDLAQEMEDVDFEEEEEEEGNEEGWVLEPQEGVVGSMEGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQRPDR", "length": 434 }, "evidence": [ { "id": "Q3SZK1", "url": "https://omabrowser.org/oma/group/Q3SZK1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q55E90-1", "protein_name": "WD40 repeat-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEDPNGNLEEDAEYYDPNDEAGEYAIEGGQLDQDDEMMDEQDHEEHEDEPQEEEEDLVDESVQGFFEHTDSVYCVSINKTFPDIIATGGGDDVAYLWDLNSGEKVHQLKGHSDSISSIEFNYDGKLVATGGMDGIVKVWDVQTGNLLINLEGPTESVEWIQWHSKGNILLAGSSDCLGFMWSTLKGDILGTFAGHSGPVTCGMFTPDGKKVITGSEDCSIKVWNPKDSSNIMSFSGHGFHEKIITCLDIKNDNTLVLSGGDDHYAVLSNINTGKVIGKLHGHTDSIVAVSMSNHNQSFCHTGSLDGSIRVWDMNTLQQRSTFKHKSSITKLKSHPHEPLLFSSSVDKSIGVWDERNGQLIKQFTGHQDAILDFDITLDGKVVTASDDKVSLVFSLNPPQN", "length": 400 }, "evidence": [ { "id": "Q3SZK1", "url": "https://omabrowser.org/oma/group/Q3SZK1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK1", "url": "https://www.uniprot.org/uniprotkb/Q3SZK1" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK1", "url": "https://www.uniprot.org/uniprotkb/Q3SZK1" } ], "pmid": "" }, { "name": "positive regulation of endothelial cell migration", "id": "GO:0010595", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010595", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK1", "url": "https://www.uniprot.org/uniprotkb/Q3SZK1" } ], "pmid": "" }, { "name": "smooth muscle cell migration", "id": "GO:0014909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014909", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK1", "url": "https://www.uniprot.org/uniprotkb/Q3SZK1" } ], "pmid": "" }, { "name": "positive regulation of angiogenesis", "id": "GO:0045766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045766", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK1", "url": "https://www.uniprot.org/uniprotkb/Q3SZK1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK1", "url": "https://www.uniprot.org/uniprotkb/Q3SZK1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK1", "url": "https://www.uniprot.org/uniprotkb/Q3SZK1" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK1", "url": "https://www.uniprot.org/uniprotkb/Q3SZK1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZK1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 434, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZK1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZK1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 20 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3SZK4-1", "uniprot_ac": "Q3SZK4", "uniprot_id": "FAKD4_BOVIN", "mass": { "chemical_mass": 71641.0, "monoisotopic_mass": 71641.0 }, "refseq": { "ac": "NP_001070435", "name": "FAST kinase domain-containing protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070435" }, "gene_names": [ { "name": "TBRG4", "type": "recommended", "evidence": [ { "id": "Q3SZK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZK4" } ] }, { "name": "TBFG4", "type": "synonym", "evidence": [ { "id": "NP_001070435", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070435" } ] }, { "name": "TBRG4", "type": "synonym", "evidence": [ { "id": "NP_001070435", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070435" } ] } ], "protein_names": [ { "name": "FAST kinase domain-containing protein 4", "type": "recommended", "evidence": [ { "id": "Q3SZK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZK4/entry#names_and_taxonomy" } ] }, { "name": "FAST kinase domain-containing protein 4", "type": "synonym", "evidence": [ { "id": "NP_001070435", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070435" } ] }, { "name": "Protein TBRG4", "type": "synonym", "evidence": [ { "id": "Q3SZK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZK4/entry#names_and_taxonomy" } ] }, { "name": "Transforming growth factor beta regulator 4", "type": "synonym", "evidence": [ { "id": "Q3SZK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZK4/entry#names_and_taxonomy" } ] }, { "name": "cell cycle progression 2", "type": "synonym", "evidence": [ { "id": "NP_001070435", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070435" } ] }, { "name": "protein TBRG4", "type": "synonym", "evidence": [ { "id": "NP_001070435", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070435" } ] } ], "function": [ { "annotation": "Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK4", "url": "https://www.uniprot.org/uniprotkb/Q3SZK4#function" }, { "database": "UniProtKB", "id": "Q969Z0", "url": "https://www.uniprot.org/uniprotkb/Q969Z0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZK4", "url": "https://www.uniprot.org/uniprotkb/Q3SZK4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBRG4", "url": "https://www.uniprot.org/uniprotkb/Q3SZK4", "locus": { "chromosome": "4", "start_pos": 76531883, "end_pos": 76522735, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010504", "url": "https://www.ensembl.org/id/ENSBTAG00000010504" } ] } } ], "crossref": [ { "id": "Q3SZK4", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZK4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd23739", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23739", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "767855", "url": "https://www.ncbi.nlm.nih.gov/gene/767855", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010622", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010622", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013584", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013584", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767855", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767855", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZK4", "url": "https://www.orthodb.org/?gene=Q3SZK4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21228", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21228", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21228:SF59", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21228:SF59", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06743", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06743", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08368", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08368", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070435", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZK4", "url": "https://www.uniprot.org/uniprotkb/Q3SZK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZK4-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZK4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAARLVRRCTCLLREAARLAPAVSPVGQLRLPQGTQKPLTSSATSPSSRLPGLLSEFVEKEQVFTPYTGRQEVEQLIEKATQPEELLELLGSGHCLQQNHAALALIQLSRLLSEKPKDKAALIQDARFWQLLHLVNSQITVVWHGTLVKLLRSLYTLGLPATSKDLRSVEQEVRWRMRRLKYKHLAFLAESSATYMQEQGSRELLAELLVHLERRWAEIEDRRMVVAMMMKTGHLSESLMNRLEDKCLELVEQFGPEELRKVLVTLAAQNRRSVPLLRAISYHLVQKPFPLTKSILLDLAYAYGKLGFHQTQVFQRLAADLLPHTPSMTSSEVARCTKSFAFLKWLNLPLFEAFVQHVLDRAQSITLPHLCNMLLAFARVNFRPEREDPFFSLVHEKLGSELVGLEPALQVDVVWALCVLQQVREAELQAVLCPEFHTQFLGGKSPKDQSTFQKLLHINATAQLEHPEYTGPLLPTSALVPSPSALEQKMTPLQKELQETLKGLLGSADKGSFMVPTQYGWVLDAEVLLDTESQLLPLRDFVAPHLTPPSGSQPLPPGAKRLAFLRWEFPNFNSRSKDLLGRFMLARRHLLAAGFLLVDVPYYEWMELKSEWQKSAYLKDKMRKAVAEELAK", "length": 632, "header": "sp|Q3SZK4-1|FAKD4_BOVIN Isoform 1 of FAST kinase domain-containing protein 4 OS=Bos taurus OX=9913 GN=TBRG4 PE=2 SV=1 CANONICAL=Q3SZK4-1" }, "isoforms": [ { "isoform_ac": "Q3SZK4-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZK4/entry#Q3SZK4-1", "sequence": { "sequence": "MAARLVRRCTCLLREAARLAPAVSPVGQLRLPQGTQKPLTSSATSPSSRLPGLLSEFVEKEQVFTPYTGRQEVEQLIEKATQPEELLELLGSGHCLQQNHAALALIQLSRLLSEKPKDKAALIQDARFWQLLHLVNSQITVVWHGTLVKLLRSLYTLGLPATSKDLRSVEQEVRWRMRRLKYKHLAFLAESSATYMQEQGSRELLAELLVHLERRWAEIEDRRMVVAMMMKTGHLSESLMNRLEDKCLELVEQFGPEELRKVLVTLAAQNRRSVPLLRAISYHLVQKPFPLTKSILLDLAYAYGKLGFHQTQVFQRLAADLLPHTPSMTSSEVARCTKSFAFLKWLNLPLFEAFVQHVLDRAQSITLPHLCNMLLAFARVNFRPEREDPFFSLVHEKLGSELVGLEPALQVDVVWALCVLQQVREAELQAVLCPEFHTQFLGGKSPKDQSTFQKLLHINATAQLEHPEYTGPLLPTSALVPSPSALEQKMTPLQKELQETLKGLLGSADKGSFMVPTQYGWVLDAEVLLDTESQLLPLRDFVAPHLTPPSGSQPLPPGAKRLAFLRWEFPNFNSRSKDLLGRFMLARRHLLAAGFLLVDVPYYEWMELKSEWQKSAYLKDKMRKAVAEELAK", "length": 632, "header": "sp|Q3SZK4-1|FAKD4_BOVIN Isoform 1 of FAST kinase domain-containing protein 4 OS=Bos taurus OX=9913 GN=TBRG4 PE=2 SV=1 CANONICAL=Q3SZK4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767855", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767855", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "mRNA metabolic process", "id": "GO:0016071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016071", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK4", "url": "https://www.uniprot.org/uniprotkb/Q3SZK4" } ], "pmid": "" }, { "name": "mitochondrial RNA processing", "id": "GO:0000963", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000963", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK4", "url": "https://www.uniprot.org/uniprotkb/Q3SZK4" } ], "pmid": "" }, { "name": "regulation of mitochondrial mRNA stability", "id": "GO:0044528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044528", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK4", "url": "https://www.uniprot.org/uniprotkb/Q3SZK4" } ], "pmid": "" }, { "name": "mitochondrial mRNA processing", "id": "GO:0090615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090615", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK4", "url": "https://www.uniprot.org/uniprotkb/Q3SZK4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK4", "url": "https://www.uniprot.org/uniprotkb/Q3SZK4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK4", "url": "https://www.uniprot.org/uniprotkb/Q3SZK4" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK4", "url": "https://www.uniprot.org/uniprotkb/Q3SZK4" } ], "pmid": "" }, { "name": "ribonucleoprotein granule", "id": "GO:0035770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035770", "evidence": [ { "database": "UniProtKB", "id": "Q3SZK4", "url": "https://www.uniprot.org/uniprotkb/Q3SZK4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 459, "end_pos": 461, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZK4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 632, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZK4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZK4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SZK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZK4" }, { "id": "PRU00619", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00619" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RAP", "eco_id": "ECO_0000255", "start_pos": 562, "end_pos": 620, "start_aa": "Leu", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 459, "end_pos": 461 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZL6-1", "uniprot_ac": "Q3SZL6", "uniprot_id": "DCP1B_BOVIN", "mass": { "chemical_mass": 62880.0, "monoisotopic_mass": 62880.0 }, "refseq": { "ac": "NP_001029639", "name": "mRNA-decapping enzyme 1B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029639" }, "gene_names": [ { "name": "DCP1B", "type": "recommended", "evidence": [ { "id": "Q3SZL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZL6" } ] }, { "name": "DCP1B", "type": "synonym", "evidence": [ { "id": "NP_001029639", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029639" } ] } ], "protein_names": [ { "name": "mRNA-decapping enzyme 1B", "type": "recommended", "evidence": [ { "id": "Q3SZL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZL6/entry#names_and_taxonomy" } ] }, { "name": "3.6.1.62", "type": "synonym", "evidence": [ { "id": "Q3SZL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZL6/entry#names_and_taxonomy" } ] }, { "name": "DCP1 decapping enzyme homolog B", "type": "synonym", "evidence": [ { "id": "NP_001029639", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029639" } ] }, { "name": "mRNA-decapping enzyme 1B", "type": "synonym", "evidence": [ { "id": "NP_001029639", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029639" } ] } ], "function": [ { "annotation": "May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZL6", "url": "https://www.uniprot.org/uniprotkb/Q3SZL6#function" }, { "database": "UniProtKB", "id": "Q9NPI6", "url": "https://www.uniprot.org/uniprotkb/Q9NPI6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZL6", "url": "https://www.uniprot.org/uniprotkb/Q3SZL6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DCP1B", "url": "https://www.uniprot.org/uniprotkb/Q3SZL6", "locus": { "chromosome": "5", "start_pos": 108315554, "end_pos": 108358036, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030285", "url": "https://www.ensembl.org/id/ENSBTAG00000030285" } ] } } ], "crossref": [ { "id": "Q3SZL6", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZL6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd09804", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09804", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514548", "url": "https://www.ncbi.nlm.nih.gov/gene/514548", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010334", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010334", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031953", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031953", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514548", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514548", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZL6", "url": "https://www.orthodb.org/?gene=Q3SZL6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16290", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16290", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16290:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16290:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06058", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06058", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16741", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16741", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029639", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "67484", "url": "https://www.rhea-db.org/rhea/67484", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZL6", "url": "https://www.uniprot.org/uniprotkb/Q3SZL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZL6-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZL6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVAGGPAGKGRDISLAALRRHDPYISRIVDVASQVALYTFGHRANEWEKTDVEGTLFVYSRSASPKHGFTIMNRLSMENRTEPITKDLDFLLQDPFLLYRNARLSIYGIWFYDKEECQRIAELMKNLTQYEQLKAHHGTGAGASPVSLGSGEGKEADILRMLTKAKDEYTKCKTCSEPKQISSSSAIHDNPNLIKPIPVKPSGSRQQRGPRPGQTSDPEPQHLSLTALFGKQDKAPCQEATGPPQTLPLQQQQPEKFPMRQGVVRSLSYEEPRRPSPPVDKQLCPAIQKLMVRSMDLQPLAELPESRPCTDALRAACAGPAQTGSPRSHALAAPGTQKLLQVQSIPGAENRCEPGAPAPASSATTPVSLAQPTRLSSALPPQTPGPRALPRPAPPGPGPGHQPVTGPGEVSPRELLRRLQAVQQEQQLPAPGRPALAAKFPTATLSTRARNPLEPWRDPPPSTEQPAPLLQVLSPQRIPAAATPPPLMSPLVFAQPSWAPPQERSRAPLPPGNQDPAATPTGLLLPLRTPEPPGTPGSALSKLQLQEALLHLIQNDDNFLNIIYEAYLFSLTQAAVKKTL", "length": 581, "header": "sp|Q3SZL6-1|DCP1B_BOVIN Isoform 1 of mRNA-decapping enzyme 1B OS=Bos taurus OX=9913 GN=DCP1B PE=2 SV=1 CANONICAL=Q3SZL6-1" }, "isoforms": [ { "isoform_ac": "Q3SZL6-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZL6/entry#Q3SZL6-1", "sequence": { "sequence": "MAVAGGPAGKGRDISLAALRRHDPYISRIVDVASQVALYTFGHRANEWEKTDVEGTLFVYSRSASPKHGFTIMNRLSMENRTEPITKDLDFLLQDPFLLYRNARLSIYGIWFYDKEECQRIAELMKNLTQYEQLKAHHGTGAGASPVSLGSGEGKEADILRMLTKAKDEYTKCKTCSEPKQISSSSAIHDNPNLIKPIPVKPSGSRQQRGPRPGQTSDPEPQHLSLTALFGKQDKAPCQEATGPPQTLPLQQQQPEKFPMRQGVVRSLSYEEPRRPSPPVDKQLCPAIQKLMVRSMDLQPLAELPESRPCTDALRAACAGPAQTGSPRSHALAAPGTQKLLQVQSIPGAENRCEPGAPAPASSATTPVSLAQPTRLSSALPPQTPGPRALPRPAPPGPGPGHQPVTGPGEVSPRELLRRLQAVQQEQQLPAPGRPALAAKFPTATLSTRARNPLEPWRDPPPSTEQPAPLLQVLSPQRIPAAATPPPLMSPLVFAQPSWAPPQERSRAPLPPGNQDPAATPTGLLLPLRTPEPPGTPGSALSKLQLQEALLHLIQNDDNFLNIIYEAYLFSLTQAAVKKTL", "length": 581, "header": "sp|Q3SZL6-1|DCP1B_BOVIN Isoform 1 of mRNA-decapping enzyme 1B OS=Bos taurus OX=9913 GN=DCP1B PE=2 SV=1 CANONICAL=Q3SZL6-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true 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"https://www.ncbi.nlm.nih.gov/protein/NP_001029526" } ] }, { "name": "MKI67 FHA domain-interacting nucleolar phosphoprotein", "type": "synonym", "evidence": [ { "id": "NP_001029526", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029526" } ] }, { "name": "Nucleolar protein interacting with the FHA domain of pKI-67", "type": "synonym", "evidence": [ { "id": "Q3SZM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZM1/entry#names_and_taxonomy" } ] }, { "name": "nucleolar phosphoprotein Nopp34", "type": "synonym", "evidence": [ { "id": "NP_001029526", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029526" } ] }, { "name": "nucleolar protein interacting with the FHA domain of pKI-67", "type": "synonym", "evidence": [ { "id": "NP_001029526", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029526" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZM1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NIFK", "url": "https://www.uniprot.org/uniprotkb/Q3SZM1", "locus": { "chromosome": "2", "start_pos": 73387424, "end_pos": 73398160, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019387", "url": "https://www.ensembl.org/id/ENSBTAG00000019387" } ] } } ], "crossref": [ { "id": "Q3SZM1", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZM1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019387", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019387", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12307", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12307", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509598", "url": "https://www.ncbi.nlm.nih.gov/gene/509598", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021043", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021043", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509598", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509598", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FECKDVA", "url": "https://omabrowser.org/oma/group/FECKDVA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZM1", "url": "https://www.orthodb.org/?gene=Q3SZM1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46754", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46754", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12196", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12196", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029526", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZM1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZM1-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAFGGPAKPLLSLNPQEDAKFKKEVAQVRRRATKQQEKQKPTPGVIYVGHLPPTLYETQIRAYFSQFGTVTRFRLSRSKKTGNSKGYGFVEFESEDVAKIAAETMNNYLFGERLLKCHFIPPEKVHEELFREWHMPFKRPSYPAVKRYNQNRSLVQKLRMEERFKKKEKLLRKRLAKKGIDYNFPSLVKVLHKNEENASNTGPQNSRKHQALRKKKKAASVTPETPEKAVDSQGPTPVCTPAFLEKRKSEVAKMNDDDKDNEIVFKQPVSGVKEETQETQSPASSKKKRRRKHNQ", "length": 296, "header": "sp|Q3SZM1-1|MK67I_BOVIN Isoform 1 of MKI67 FHA domain-interacting nucleolar phosphoprotein OS=Bos taurus OX=9913 GN=NIFK PE=2 SV=1 CANONICAL=Q3SZM1-1" }, "isoforms": [ { "isoform_ac": "Q3SZM1-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM1/entry#Q3SZM1-1", "sequence": { "sequence": "MAAFGGPAKPLLSLNPQEDAKFKKEVAQVRRRATKQQEKQKPTPGVIYVGHLPPTLYETQIRAYFSQFGTVTRFRLSRSKKTGNSKGYGFVEFESEDVAKIAAETMNNYLFGERLLKCHFIPPEKVHEELFREWHMPFKRPSYPAVKRYNQNRSLVQKLRMEERFKKKEKLLRKRLAKKGIDYNFPSLVKVLHKNEENASNTGPQNSRKHQALRKKKKAASVTPETPEKAVDSQGPTPVCTPAFLEKRKSEVAKMNDDDKDNEIVFKQPVSGVKEETQETQSPASSKKKRRRKHNQ", "length": 296, "header": "sp|Q3SZM1-1|MK67I_BOVIN Isoform 1 of MKI67 FHA domain-interacting nucleolar phosphoprotein OS=Bos taurus OX=9913 GN=NIFK PE=2 SV=1 CANONICAL=Q3SZM1-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 237, "start_aa": "Thr", "end_pos": 237, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr237", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 43, "start_aa": "Thr", "end_pos": 43, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr43", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 221, "end_pos": 221, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZM1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM1" } ], "site_lbl": "Ser221" }, { "start_pos": 226, "end_pos": 226, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZM1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM1" } ], "site_lbl": "Thr226" }, { "start_pos": 233, "end_pos": 233, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZM1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM1" } ], "site_lbl": "Ser233" }, { "start_pos": 237, "end_pos": 237, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZM1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM1" } ], "site_lbl": "Thr237" }, { "start_pos": 241, "end_pos": 241, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZM1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM1" } ], "site_lbl": "Thr241" }, { "start_pos": 250, "end_pos": 250, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3SZM1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM1" } ], "site_lbl": "Ser250" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:509598", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509598", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RXX7-1", "protein_name": "Nucleolar protein interacting with the FHA domain of MKI67", "gene_name": "NIFK", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAALAAQVGPLLSLNPQEDAKFQKKVALARRRATKQPEKQKLTPGVIYVGHLPPSLYETQIRAYFSQFGTVTRLRLSRSKKTGNSKGYGFVEFESEDVARIAAETMNNYLFGERLLKCHIIPPEKVHEELFREWHMPFKRPSFPAVKRYNQKRTLRQKLRMEERFKKKEKSLRKRLAKKGIDYNFPSLVLHKDEEKPSFTGPRNSRKHQALRKKKKKEALAALNTPEKTVDSQGPTPVCTPTFLEKRKSEVAKMNDDDKDHEIVFKQPVSGAKEETQETQIPTSSRKKRRKNNQ", "length": 294 }, "evidence": [ { "id": "Q3SZM1", "url": "https://omabrowser.org/oma/group/Q3SZM1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5RJM0-1", "protein_name": "MKI67 FHA domain-interacting nucleolar phosphoprotein", "gene_name": "Nifk", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEYSGPAKPTLALNPREDSQFEKDLTQIQRRAKKKKEEKLNSGVVYLGHLPSTLSESHIYDYCAQFGDIRRFRLSRSKRTGNSRGFAFVEFESEDVAKIVAETMDNYLFGERLLSCKFMPREKVHKDLFNQCNVPFHPPSFPAVKRYNQKRGHLQMLKMEYRFKKKEKLLRKKLAKKGIDYSFPSLVLPKPKKEISSIANTHGDSEANQDPTPVCTPTFLERRKSQLMEINDDDEIILKLPVSPVKEDTQKTPAPESSGKKRLRKRKSKQ", "length": 271 }, "evidence": [ { "id": "Q3SZM1", "url": "https://omabrowser.org/oma/group/Q3SZM1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8JIY8-1", "protein_name": "MKI67 FHA domain-interacting nucleolar phosphoprotein", "gene_name": "nifk", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTEGKSSDKPAKRLLALNPKEDAEFQKKVQQVKKRPQTGQTLSPGVLYVGHLPRGLFEPQLKSYFEQFGKVLRLRVSRSKKTGGSKGYGFVEFECDEVAKIVAETMNNYLMGERIIKCHVIPPEKVHEKLFVGSIAGFKKPKYPAVTRYNKTHTEDDVKKVGTKLLSKESKLRKRLAAKGIDYDFPGFAAQIPAKKAPSEANVSVCSEDVTPVCTPSLLERRKSLRVEDDDVDDEIVIKVKPLPENSDDVEESEEESAEEDEGEEEEAA", "length": 269 }, "evidence": [ { "id": "Q3SZM1", "url": "https://omabrowser.org/oma/group/Q3SZM1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q91VE6-1", "protein_name": "MKI67 FHA domain-interacting nucleolar phosphoprotein", "gene_name": "Nifk", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGLAGPAKPSLALNPQEDSQFEKALTQIQGRTKKPQQKKKEKLNRGVVYLGHLPSTLSESHIYNYCAQFGDISRFRLSRSKRTGNSKGYAFVEFESEDVAKIVAETMDNYLFGERLLSCKFMPRKKVHKDLFSQRNALFHRPSFPAVKRYNRKRGHLQMLKMEYRFKKKEKLLRKKLAAKGIDYSFPSLVLPKPKNIAVAHRDSEGNQVLPDQKEGLSGEPRRKEKMMKEDISNNIPKKRKRSRRKKSSVDSQGPTPVCTPTFLERRKSQVMEVGGDKDDEIILKLPVPPVKEDTQKTPTSASPGGKRPRKRKSKQ", "length": 317 }, "evidence": [ { "id": "Q3SZM1", "url": "https://omabrowser.org/oma/group/Q3SZM1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BYG3-1", "protein_name": "MKI67 FHA domain-interacting nucleolar phosphoprotein", "gene_name": "NIFK", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATFSGPAGPILSLNPQEDVEFQKEVAQVRKRITQRKKQEQLTPGVVYVRHLPNLLDETQIFSYFSQFGTVTRFRLSRSKRTGNSKGYAFVEFESEDVAKIVAETMNNYLFGERLLECHFMPPEKVHKELFKDWNIPFKQPSYPSVKRYNRNRTLTQKLRMEERFKKKERLLRKKLAKKGIDYDFPSLILQKTESISKTNRQTSTKGQVLRKKKKKVSGTLDTPEKTVDSQGPTPVCTPTFLERRKSQVAELNDDDKDDEIVFKQPISCVKEEIQETQTPTHSRKKRRRSSNQ", "length": 293 }, "evidence": [ { "id": "Q3SZM1", "url": "https://omabrowser.org/oma/group/Q3SZM1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q3SZM1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q3SZM1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM1" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "Q3SZM1", "url": "https://www.uniprot.org/uniprotkb/Q3SZM1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZM1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 296, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZM1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZM1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SZM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZM1" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000255", "start_pos": 45, "end_pos": 123, "start_aa": "Gly", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 43, 237 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 221, 226, 233, 237, 241, 250 ], "sequon_annotation_sites": [ { "start_pos": 152, "end_pos": 154 }, { "start_pos": 198, "end_pos": 200 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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}, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZQ2-1", "uniprot_ac": "Q3SZQ2", "uniprot_id": "S22AH_BOVIN", "mass": { "chemical_mass": 60174.0, "monoisotopic_mass": 60174.0 }, "refseq": { "ac": "XP_010807280", "name": "solute carrier family 22 member 17 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807280" }, "gene_names": [ { "name": "SLC22A17", "type": "recommended", "evidence": [ { "id": "Q3SZQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ2" } ] }, { "name": "24p3R", "type": "synonym", "evidence": [ { "id": "XP_010807280", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807280" } ] }, { "name": "SLC22A17", "type": "synonym", "evidence": [ { "id": "XP_010807280", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807280" } ] } ], "protein_names": [ { "name": "Solute carrier family 22 member 17", "type": "recommended", "evidence": [ { "id": "Q3SZQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ2/entry#names_and_taxonomy" } ] }, { "name": "24p3 receptor", "type": "synonym", "evidence": [ { "id": "Q3SZQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ2/entry#names_and_taxonomy" } ] }, { "name": "24p3R", "type": "synonym", "evidence": [ { "id": "Q3SZQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ2/entry#names_and_taxonomy" } ] }, { "name": "Lipocalin-2 receptor", "type": "synonym", "evidence": [ { "id": "Q3SZQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ2/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 22 member 17 isoform X1", "type": "synonym", "evidence": [ { "id": 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Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ2", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ2", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC22A17", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ2", "locus": { "chromosome": "10", "start_pos": 21578551, "end_pos": 21572374, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016467", "url": "https://www.ensembl.org/id/ENSBTAG00000016467" } ] } } ], "crossref": [ { "id": "Q3SZQ2", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZQ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016467", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016467", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17445", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17445", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539848", "url": "https://www.ncbi.nlm.nih.gov/gene/539848", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005829", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005829", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539848", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539848", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ITRVELC", "url": "https://omabrowser.org/oma/group/ITRVELC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZQ2", "url": "https://www.orthodb.org/?gene=Q3SZQ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24064", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24064", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00083", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00083", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-917937", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-917937", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010807280", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807280", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZQ2", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZQ2-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSSLSLAVPPGPLSFEALLAQVGALGGGQQLQLGLCCLPVLFVALGLASDPIFTLAPPLHCHYGAFPPNASGWEQPPNASGVSVASAALAASAASRLATSTDPSCSGFAPPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLALLGLWDYLNEAAITTFSVLGLFSSQAAGILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLQQPPPNRCDHVPLLATPNPAL", "length": 567, "header": "sp|Q3SZQ2-1|S22AH_BOVIN Isoform 1 of Solute carrier family 22 member 17 OS=Bos taurus OX=9913 GN=SLC22A17 PE=2 SV=1 CANONICAL=Q3SZQ2-1" }, "isoforms": [ { "isoform_ac": "Q3SZQ2-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ2/entry#Q3SZQ2-1", "sequence": { "sequence": "MGSSLSLAVPPGPLSFEALLAQVGALGGGQQLQLGLCCLPVLFVALGLASDPIFTLAPPLHCHYGAFPPNASGWEQPPNASGVSVASAALAASAASRLATSTDPSCSGFAPPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLALLGLWDYLNEAAITTFSVLGLFSSQAAGILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLQQPPPNRCDHVPLLATPNPAL", "length": 567, "header": "sp|Q3SZQ2-1|S22AH_BOVIN Isoform 1 of Solute carrier family 22 member 17 OS=Bos taurus OX=9913 GN=SLC22A17 PE=2 SV=1 CANONICAL=Q3SZQ2-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 70, "start_aa": "Asn", "end_pos": 70, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn70", "evidence": [ { "id": "Q3SZQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ2#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 79, "start_aa": "Asn", "end_pos": 79, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn79", "evidence": [ { "id": "Q3SZQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ2#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539848", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539848", "resource": "KEGG Pathway" }, { "id": "R-BTA-917937", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-917937", "resource": "Reactome", "description": "Iron uptake and transport" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transmembrane signaling receptor activity", "id": "GO:0004888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ2", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ2" } ], "pmid": "" }, { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ2", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ2", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ2" } ], "pmid": "" }, { "name": "vacuolar membrane", "id": "GO:0005774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005774", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ2", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ2" } ], "pmid": "" }, { "name": "organelle membrane", "id": "GO:0031090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031090", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ2", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "siderophore transport", "id": "GO:0015891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015891", "evidence": [ { "database": "UniProtKB", "id": "Q3SZQ2", "url": "https://www.uniprot.org/uniprotkb/Q3SZQ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" }, { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZQ2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 567, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZQ2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZQ2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 70, 79 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 70, "end_pos": 72 }, { "start_pos": 79, "end_pos": 81 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZR6-1", "uniprot_ac": "Q3SZR6", "uniprot_id": "TM147_BOVIN", "mass": { "chemical_mass": 25321.0, "monoisotopic_mass": 25321.0 }, "refseq": { "ac": "NP_001029796", "name": "BOS complex subunit TMEM147", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029796" }, "gene_names": [ { "name": "TMEM147", "type": "recommended", "evidence": [ { "id": "Q3SZR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR6" } ] }, { "name": "TMEM147", "type": "synonym", "evidence": [ { "id": "NP_001029796", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029796" } ] } ], "protein_names": [ { "name": "BOS complex subunit TMEM147", "type": "recommended", "evidence": [ { "id": "Q3SZR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR6/entry#names_and_taxonomy" } ] }, { "name": "BOS complex subunit TMEM147", "type": "synonym", "evidence": [ { "id": "NP_001029796", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029796" } ] }, { "name": "Transmembrane protein 147", "type": "synonym", "evidence": [ { "id": "Q3SZR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZR6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Regulates LBR localization to the nucleus inner membrane.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR6", "url": "https://www.uniprot.org/uniprotkb/Q3SZR6#function" }, { "database": "UniProtKB", "id": "Q9BVK8", "url": "https://www.uniprot.org/uniprotkb/Q9BVK8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZR6", "url": "https://www.uniprot.org/uniprotkb/Q3SZR6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM147", "url": "https://www.uniprot.org/uniprotkb/Q3SZR6", "locus": { "chromosome": "18", "start_pos": 46207471, "end_pos": 46204657, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015920", "url": "https://www.ensembl.org/id/ENSBTAG00000015920" } ] } } ], "crossref": [ { "id": "Q3SZR6", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZR6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015920", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015920", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "535038", "url": "https://www.ncbi.nlm.nih.gov/gene/535038", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535038", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535038", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SKCVYAG", "url": "https://omabrowser.org/oma/group/SKCVYAG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12869", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12869", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12869:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12869:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09767", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09767", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029796", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZR6", "url": "https://www.uniprot.org/uniprotkb/Q3SZR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZR6-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZR6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTWEGGIYDFIGEFMKASVDVADLIGLNLVMSRNAGKGEYKIMVAALGWATAELIMSRCIPLWVGARGIEFDWKYIQMSIDSNISLVHYIVASAQVWMITRYDLYHTYRPAVLLLMFLSVYKAFVMETFVHLCSLGSWTALLARALVTGLLALSTLALYVAVVNVHS", "length": 224, "header": "sp|Q3SZR6-1|TM147_BOVIN Isoform 1 of BOS complex subunit TMEM147 OS=Bos taurus OX=9913 GN=TMEM147 PE=2 SV=1 CANONICAL=Q3SZR6-1" }, "isoforms": [ { "isoform_ac": "Q3SZR6-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZR6/entry#Q3SZR6-1", "sequence": { "sequence": "MTLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTWEGGIYDFIGEFMKASVDVADLIGLNLVMSRNAGKGEYKIMVAALGWATAELIMSRCIPLWVGARGIEFDWKYIQMSIDSNISLVHYIVASAQVWMITRYDLYHTYRPAVLLLMFLSVYKAFVMETFVHLCSLGSWTALLARALVTGLLALSTLALYVAVVNVHS", "length": 224, "header": "sp|Q3SZR6-1|TM147_BOVIN Isoform 1 of BOS complex subunit TMEM147 OS=Bos taurus OX=9913 GN=TMEM147 PE=2 SV=1 CANONICAL=Q3SZR6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:535038", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535038", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZM71-1", "protein_name": "BOS complex subunit TMEM147", "gene_name": "TMEM147", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTWEGGIYDFIGEFMKASVDVADLIGLNLVMSRNAGKGEYKIMVAALGWATAELIMSRCIPLWVGARGIEFDWKYIQMSIDSNISLVHYIVASAQVWMITRYDLYHTFRPAVLLLMFLSVYKAFVMETFVHLCSLGSWTALLARAVVTGLLALSTLALYVAVVNVHS", "length": 224 }, "evidence": [ { "id": "Q3SZR6", "url": "https://omabrowser.org/oma/group/Q3SZR6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q2TA63-1", "protein_name": "BOS complex subunit TMEM147", "gene_name": "Tmem147", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTWEGGIYDFIGEFMKASVDVADLIGLNLVMSRNAGKGEYKIMVAALGWATAELIMSRCIPLWVGARGIEFDWKYIQMSIDSNISLVHYIVASAQVWMITRYDLYHTFRPAVLLLMFLSVYKAFVMETFVHLCSLGSWTALLARAVVTGLLALSTLALYVAVVNVHS", "length": 224 }, "evidence": [ { "id": "Q3SZR6", "url": "https://omabrowser.org/oma/group/Q3SZR6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q54BM6-1", "protein_name": "BOS complex subunit TMEM147", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTFLYFSSCLLITFSPFYIIYKSLKLNEIKSNQLILYGFIGCIFTQFLKMLIIATFLPSFNTTSIGIYPEIIKIICNVIDLFSMSLVLKFAEFSGSKDYRILGIGIGWSFSHAIMSQLIPLLMGTLSISFDFSYYLDSIESNFIAIQQLVVFKLLYLYNKYYNENGKQQQEQKQQQQHEILSPDLVKILLIVFLTMNSILELIQHHFSISHIHFVVIQFLYTLTFFYYSKYKFIK", "length": 235 }, "evidence": [ { "id": "Q3SZR6", "url": "https://omabrowser.org/oma/group/Q3SZR6/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9BVK8-1", "protein_name": "BOS complex subunit TMEM147", "gene_name": "TMEM147", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTWEGGIYDFIGEFMKASVDVADLIGLNLVMSRNAGKGEYKIMVAALGWATAELIMSRCIPLWVGARGIEFDWKYIQMSIDSNISLVHYIVASAQVWMITRYDLYHTFRPAVLLLMFLSVYKAFVMETFVHLCSLGSWAALLARAVVTGLLALSTLALYVAVVNVHS", "length": 224 }, "evidence": [ { "id": "Q3SZR6", "url": "https://omabrowser.org/oma/group/Q3SZR6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CQG6-1", "protein_name": "BOS complex subunit TMEM147", "gene_name": "Tmem147", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTWEGGIYDFIGEFMKASVDVADLIGLNLVMSRNAGKGEYKIMVAALGWATAELIMSRCIPLWVGARGIEFDWKYIQMSIDSNISLVHYIVASAQVWMITRYDLYHTFRPAVLLLMFLSVYKAFVMETFVHLFSLGSWTALLARAVVTGLLALSTLALYVAVVNVHS", "length": 224 }, "evidence": [ { "id": "Q3SZR6", "url": "https://omabrowser.org/oma/group/Q3SZR6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9SX96-1", "protein_name": "BOS complex subunit TMEM147", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MTLFHFFNCAILTFGPHAVYYSATPLSEYDTLGTSVKAAVVYLATALVKLVCLATFLQVSETEVFDPYQEALKAMIGFIDVAGLYYALAQLTHRNISQNHKFQAVGLGWAFADSVLHRLAPLWVGARGLEFTWDYVLQGLEANANLVFTISLAALGSLMWLRKNKPKSLIPIIYTCAVIIATMPSITSYLKRVNGWHFPKIVGFELATSLVMAFISCQLFILCQRPSL", "length": 228 }, "evidence": [ { "id": "Q3SZR6", "url": "https://omabrowser.org/oma/group/Q3SZR6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9V3I6-1", "protein_name": "BOS complex subunit TMEM147", "gene_name": "anon-35Fc", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTLYHFGNCVALLTPYYFTYKYSGLSEYGAFWKCVQAGGIYIFTQLVKMLVLATFFYSDAPSSSGEFNFFAEILRCSMDIADLLGFALILSRIPGKGHSKLITAGLGWATAEVILSRGIMLWVGARGTEFSWIYILKCLESNVLLVQHITTATLIWLFTRHDLNKALKPLVSLLLAVTVFKGVWLEGMLHILTIGPWLTVAVKALVAAVIGFCTLHIYSGLAQQIGI", "length": 227 }, "evidence": [ { "id": "Q3SZR6", "url": "https://omabrowser.org/oma/group/Q3SZR6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR6", "url": "https://www.uniprot.org/uniprotkb/Q3SZR6" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR6", "url": "https://www.uniprot.org/uniprotkb/Q3SZR6" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR6", "url": "https://www.uniprot.org/uniprotkb/Q3SZR6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR6", "url": "https://www.uniprot.org/uniprotkb/Q3SZR6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein localization to nuclear inner membrane", "id": "GO:0036228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036228", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR6", "url": "https://www.uniprot.org/uniprotkb/Q3SZR6" } ], "pmid": "" }, { "name": "multi-pass transmembrane protein insertion into ER membrane", "id": "GO:0160063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160063", "evidence": [ { "database": "UniProtKB", "id": "Q3SZR6", "url": "https://www.uniprot.org/uniprotkb/Q3SZR6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZR6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 224, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZR6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZR6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 140, "end_pos": 142 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3SZT7-1", "uniprot_ac": "Q3SZT7", "uniprot_id": "CDC26_BOVIN", "mass": { "chemical_mass": 9811.0, "monoisotopic_mass": 9811.0 }, "refseq": { "ac": "NP_001071621", "name": "anaphase-promoting complex subunit CDC26", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071621" }, "gene_names": [ { "name": "CDC26", "type": "recommended", "evidence": [ { "id": "Q3SZT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZT7" } ] }, { "name": "CDC26", "type": "synonym", "evidence": [ { "id": "NP_001071621", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071621" } ] } ], "protein_names": [ { "name": "Anaphase-promoting complex subunit CDC26", "type": "recommended", "evidence": [ { "id": "Q3SZT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZT7/entry#names_and_taxonomy" } ] }, { "name": "Cell division cycle protein 26 homolog", "type": "synonym", "evidence": [ { "id": "Q3SZT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZT7/entry#names_and_taxonomy" } ] }, { "name": "anaphase-promoting complex subunit CDC26", "type": "synonym", "evidence": [ { "id": "NP_001071621", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071621" } ] }, { "name": "cell division cycle 26 homolog", "type": "synonym", "evidence": [ { "id": "NP_001071621", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071621" } ] }, { "name": "cell division cycle protein 26 homolog", "type": "synonym", "evidence": [ { "id": "NP_001071621", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071621" } ] } ], "function": [ { "annotation": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). Together with the RING-H2 protein ANAPC11, forms the catalytic component of the E3 ubiquitin ligase complex (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity). May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZT7", "url": "https://www.uniprot.org/uniprotkb/Q3SZT7#function" }, { "database": "UniProtKB", "id": "Q8NHZ8", "url": "https://www.uniprot.org/uniprotkb/Q8NHZ8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZT7", "url": "https://www.uniprot.org/uniprotkb/Q3SZT7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDC26", "url": "https://www.uniprot.org/uniprotkb/Q3SZT7", "locus": { "chromosome": "8", "start_pos": 102506038, "end_pos": 102517195, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014430", "url": "https://www.ensembl.org/id/ENSBTAG00000014430" } ] } } ], "crossref": [ { "id": 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"https://omabrowser.org/oma/group/NKGVIWG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZT9", "url": "https://www.orthodb.org/?gene=Q3SZT9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11961", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11961", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00034", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00034", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071431", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZT9", "url": "https://www.uniprot.org/uniprotkb/Q3SZT9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZT9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZT9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADAEAGKKIFIQKCAQCHTVEKGGKHKTGPNLWGLFGRKTGQAPGFSYTEANKNKGIIWGEQTLMEYLENPKKYIPGTKMIFAGLKKKSEREDLIEYLKQATSS", "length": 105, "header": "sp|Q3SZT9-1|CYC2_BOVIN Isoform 1 of Cytochrome c 2 OS=Bos taurus OX=9913 GN=CYCT PE=3 SV=3 CANONICAL=Q3SZT9-1" }, "isoforms": [ { "isoform_ac": "Q3SZT9-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZT9/entry#Q3SZT9-1", "sequence": { "sequence": "MADAEAGKKIFIQKCAQCHTVEKGGKHKTGPNLWGLFGRKTGQAPGFSYTEANKNKGIIWGEQTLMEYLENPKKYIPGTKMIFAGLKKKSEREDLIEYLKQATSS", "length": 105, "header": "sp|Q3SZT9-1|CYC2_BOVIN Isoform 1 of Cytochrome c 2 OS=Bos taurus OX=9913 GN=CYCT PE=3 SV=3 CANONICAL=Q3SZT9-1" }, "locus": { "chromosome": "2", "start_pos": 18802659, "end_pos": 18789363, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031885.4", "url": "https://www.ensembl.org/id/ENSBTAT00000031885.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031831.2", "url": "https://www.ensembl.org/id/ENSBTAP00000031831.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:781996", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781996", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2QEN3-1", "protein_name": "Cytochrome c, testis-specific", "gene_name": "LOC100764460", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGDAEVGKKIFVQKCAQCHTVEKGGKHKTGPNLWGLFGRTTGQAPGFSYTEANKNKGIVWSEATLMEYLENPKKFIPGTKMVFAGIKKKSEREDLIKYLKQATSS", "length": 105 }, "evidence": [ { "id": "Q3SZT9", "url": "https://omabrowser.org/oma/group/Q3SZT9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P04657-1", "protein_name": "Cytochrome c-1", "gene_name": "Cyt-c-d", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGSGDAENGKKIFVQKCAQCHTYEVGGKHKVGPNLGGVVGRKCGTAAGYKYTDANIKKGVTWTEGNLDEYLKDPKKYIPGTKMVFAGLKKAEERADLIAFLKSNK", "length": 105 }, "evidence": [ { "id": "Q3SZT9", "url": "https://omabrowser.org/oma/group/Q3SZT9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial intermembrane space", "id": "GO:0005758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005758", "evidence": [ { "database": "UniProtKB", "id": "Q3SZT9", "url": "https://www.uniprot.org/uniprotkb/Q3SZT9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "electron transfer activity", "id": "GO:0009055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009055", "evidence": [ { "database": "UniProtKB", "id": "Q3SZT9", "url": "https://www.uniprot.org/uniprotkb/Q3SZT9" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": 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"o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { 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"Q3SZV3", "url": "https://www.uniprot.org/uniprotkb/Q3SZV3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZV3", "url": "https://www.uniprot.org/uniprotkb/Q3SZV3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EEF1G", "url": "https://www.uniprot.org/uniprotkb/Q3SZV3", "locus": {} } ], "crossref": [ { "id": "Q3SZV3", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZV3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03044", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03044", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03181", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03181", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "326581", "url": "https://www.ncbi.nlm.nih.gov/gene/326581", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001662", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001662", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004045", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004045", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004046", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004046", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010987", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010987", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050802", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050802", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:326581", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:326581", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZV3", "url": "https://www.orthodb.org/?gene=Q3SZV3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43986", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43986", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43986:SF13", "url": 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"sequence": { "sequence": "MAAGTLYTYPENWRAFKALIAAQYSGAQVRVLSAPPHFHFGQTNRTPEFLRKFPAGKVPAFEGDDGFCVFESNAIAYYVSNEELRGSTPEAAAQVVQWVSFADSDIVPPASTWVFPTLGIMHHNKQATENAKEEVRRILGLLDAHLKTRTFLVGERVTLADITVVCTLLWLYKQVLEPSFRQAFPNTNRWFLTCINQPQFRAVLGEVKLCEKMAQFDAKKFAESQPKKDTPRKEKGSREEKLKPQAERKEGKEEKKAAAPAPEEELDECEQALAAEPKAKDPFAHLPKSTFVLDEFKRKYSNEDTLSVALPYFWDHFDKDGWSLWYSEYRFPEELTQTFMSCNLITGMFQRLDKLRKNAFASVILFGTNNSSSISGVWDFRGQELAFPLSPDWQVDYESYTWRKLDPGSEETQTLVREYFCWEGAFQHVGKAFNQGKIFK", "length": 440, "header": "sp|Q3SZV3-1|EF1G_BOVIN Isoform 1 of Elongation factor 1-gamma OS=Bos taurus OX=9913 GN=EEF1G PE=2 SV=1 CANONICAL=Q3SZV3-1" }, "isoforms": [ { "isoform_ac": "Q3SZV3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZV3/entry#Q3SZV3-1", "sequence": { "sequence": 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membrane translocase subunit Tim10 B", "type": "synonym", "evidence": [ { "id": "NP_001035620", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035620" } ] }, { "name": "mitochondrial import inner membrane translocase subunit Tim9 B", "type": "synonym", "evidence": [ { "id": "NP_001035620", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035620" } ] }, { "name": "tim10b", "type": "synonym", "evidence": [ { "id": "NP_001035620", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035620" } ] }, { "name": "translocase of inner mitochondrial membrane 10 homolog B", "type": "synonym", "evidence": [ { "id": "NP_001035620", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035620" } ] } ], "function": [ { "annotation": "Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. 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"Enzyme and Pathway" ] }, { "id": "NP_001030531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030531", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZX5", "url": "https://www.uniprot.org/uniprotkb/Q3SZX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZX5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZX5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAVILERLGALWVQNLRGKLALGILPQSHIHTSASLEISRKWEKKNKIVYPPQLPGEPRRPAEIYHCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFSDKKGAQIIKEVLLEAQDMAVRDHNVEFRSNLYIAESTSGRGQYLKRIRYHGRGRFGIMEKVFCHYFVKLVEGPPPPPEAPKTAVTHAKEYIQELRNRTIIHAL", "length": 204, "header": "sp|Q3SZX5-1|RM22_BOVIN Isoform 1 of Large ribosomal subunit protein uL22m OS=Bos taurus OX=9913 GN=MRPL22 PE=1 SV=1 CANONICAL=Q3SZX5-1" }, "isoforms": [ { "isoform_ac": "Q3SZX5-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZX5/entry#Q3SZX5-1", "sequence": { "sequence": "MAAVILERLGALWVQNLRGKLALGILPQSHIHTSASLEISRKWEKKNKIVYPPQLPGEPRRPAEIYHCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFSDKKGAQIIKEVLLEAQDMAVRDHNVEFRSNLYIAESTSGRGQYLKRIRYHGRGRFGIMEKVFCHYFVKLVEGPPPPPEAPKTAVTHAKEYIQELRNRTIIHAL", "length": 204, "header": "sp|Q3SZX5-1|RM22_BOVIN Isoform 1 of Large ribosomal subunit protein uL22m OS=Bos taurus OX=9913 GN=MRPL22 PE=1 SV=1 CANONICAL=Q3SZX5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Suzuki T, Terasaki M, Takemoto-Hori C, Hanada T, Ueda T, Wada A, Watanabe K", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX5", "url": "https://www.uniprot.org/uniprotkb/Q3SZX5" } ], "reference": [ { "type": "PubMed", "id": "11279069", "url": "https://glygen.org/publication/PubMed/11279069" } ] }, { "title": "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Koc E C, Burkhart W, Blackburn K, Moyer M B, Schlatzer D M, Moseley A, Spremulli L L", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX5", "url": "https://www.uniprot.org/uniprotkb/Q3SZX5" } ], "reference": [ { "type": "PubMed", "id": "11551941", "url": "https://glygen.org/publication/PubMed/11551941" } ] }, { "title": "A structural model for the large subunit of the mammalian mitochondrial ribosome.", "journal": "J. Mol. Biol.", "date": "2006", "authors": "Mears Jason A, Sharma Manjuli R, Gutell Robin R, McCook Amanda S, Richardson Paul E, Caulfield Thomas R, Agrawal Rajendra K, Harvey Stephen C", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX5", "url": "https://www.uniprot.org/uniprotkb/Q3SZX5" } ], "reference": [ { "type": "PubMed", "id": "16510155", "url": "https://glygen.org/publication/PubMed/16510155" } ] } ], "pathway": [ { "id": "bta:614639", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614639", "resource": "KEGG Pathway" }, { "id": "R-BTA-5389840", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-9937383", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "resource": "Reactome", "description": "Mitochondrial ribosome-associated quality control" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YL12-1", "protein_name": "Large ribosomal subunit protein uL22m", "gene_name": "MRPL22", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "GRVSCTRLCSPQSLLSCSGRSFALEEQHRRVGECFSHCIPGSRRKAECVVLKVQSFGLCWSCGGQSQRWFAAGSAFPLSCIHTSTSLQKLGKWEKKNRIVYPPQLPGEPRRPAEIYHCRREIKYSKDKMWYLAKLIKGMSIDQALAQLEFNDKKGAKIIKEVLLEAQEMAVRNHNVEFKSNLHIAESLAGKGHYTKRIRLHGKGMFGIMKIVKCHYFVKLVEGPPPLPEPRKTGFDQAKEYVQQLRSRTLVHTL", "length": 254 }, "evidence": [ { "id": "Q3SZX5", "url": "https://omabrowser.org/oma/group/Q3SZX5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P0C2C0-1", "protein_name": "Large ribosomal subunit protein uL22m", "gene_name": "Mrpl22", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAALLRELGALWVPNLRIWTTQMLRVLPQSCIHTSTSLDISRRWEKKNKIVYPPQLPGEPRRPAEIYHCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFNDKKGAQIIKEVLLEAQDMAVRDHNVEFRSNLHIAESTSGRGQCLKRIRYHGRGRFGIMEKVYCHYFVKLVEGPPPRPEAPRTAVDHAKEYIQQLRSRTIIHTL", "length": 206 }, "evidence": [ { "id": "Q3SZX5", "url": "https://omabrowser.org/oma/group/Q3SZX5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BU88-1", "protein_name": "Large ribosomal subunit protein uL22m", "gene_name": "Mrpl22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAALLRELGALRVPNLRIWATQTLRVLPPSCIHTSASLDISRKWEKKNKIVYPPQLPGEPRRPAEIYHCRRQIKYSKDKMWYLAKMIRGMSIDQALAQLEFNDKKGAQIIKEVLLEAQDMAVRDHNVEFRSNLHIAESTSGRGQCLKRIRYHGRGRFGIMEKVYCHYFVKLVEGPPPPPEVPKTAVDHAKDYIQQLRSRTIIHTL", "length": 206 }, "evidence": [ { "id": "Q3SZX5", "url": "https://omabrowser.org/oma/group/Q3SZX5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NWU5-1", "protein_name": "Large ribosomal subunit protein uL22m", "gene_name": "MRPL22", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAVLGQLGALWIHNLRSRGKLALGVLPQSYIHTSASLDISRKWEKKNKIVYPPQLPGEPRRPAEIYHCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEFRSNLYIAESTSGRGQCLKRIRYHGRGRFGIMEKVYCHYFVKLVEGPPPPPEPPKTAVAHAKEYIQQLRSRTIVHTL", "length": 206 }, "evidence": [ { "id": "Q3SZX5", "url": "https://omabrowser.org/oma/group/Q3SZX5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VXB5-1", "protein_name": "Large ribosomal subunit protein uL22m", "gene_name": "mRpL22", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MHKVIRQMSQLRLQAPQGAALLRSADSSSISPAISPVSPPALQSKSLHTAASAGMLCAKWNKYNYGPRKWLEYNKTVHPPQETDEEPRNAYVCHMRSNIKYSPDKMWYIAAFVRGMSVDEALKQLNFVLKKGATDVKETILEAQQIAVERHNVEYKSNLWIAESFVGKGRVFKGVRRHARGRFGKVEYKHCHYFVRLEEGEPPQHYYQEPQTPEQQYESWMEQMRSRKIINSL", "length": 233 }, "evidence": [ { "id": "Q3SZX5", "url": "https://omabrowser.org/oma/group/Q3SZX5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX5", "url": "https://www.uniprot.org/uniprotkb/Q3SZX5" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX5", "url": "https://www.uniprot.org/uniprotkb/Q3SZX5" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX5", "url": "https://www.uniprot.org/uniprotkb/Q3SZX5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX5", "url": "https://www.uniprot.org/uniprotkb/Q3SZX5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3SZX5", "url": "https://www.uniprot.org/uniprotkb/Q3SZX5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 197, "end_pos": 199, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZX5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 204, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZX5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZX5" }, { "pdb_id": "2ftc", "pdb_chain": "m", "start_pos": 67, "end_pos": 176, "overlap": "1.0", "method": "Electron_Microscopy", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/2ftc.pdb", "url_external": "https://www.rcsb.org/structure/2ftc" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 197, "end_pos": 199 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3SZY3-1", "uniprot_ac": "Q3SZY3", "uniprot_id": "PTTG1_BOVIN", "mass": { "chemical_mass": 22132.0, "monoisotopic_mass": 22132.0 }, "refseq": { "ac": "NP_001029482", "name": "securin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029482" }, "gene_names": [ { "name": "PTTG1", "type": "recommended", "evidence": [ { "id": "Q3SZY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY3" } ] }, { "name": "PTTG1", "type": "synonym", "evidence": [ { "id": "NP_001029482", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029482" } ] } ], "protein_names": [ { "name": "Securin", "type": "recommended", "evidence": [ { "id": "Q3SZY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY3/entry#names_and_taxonomy" } ] }, { "name": "Pituitary tumor-transforming gene 1 protein", "type": "synonym", "evidence": [ { "id": "Q3SZY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZY3/entry#names_and_taxonomy" } ] }, { "name": "pituitary tumor-transforming 1", "type": "synonym", "evidence": [ { "id": "NP_001029482", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029482" } ] }, { "name": "pituitary tumor-transforming gene 1 protein", "type": "synonym", "evidence": [ { "id": "NP_001029482", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029482" } ] }, { "name": "securin", "type": "synonym", "evidence": [ { "id": "NP_001029482", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029482" } ] } ], "function": [ { "annotation": "Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY3", "url": "https://www.uniprot.org/uniprotkb/Q3SZY3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZY3", "url": "https://www.uniprot.org/uniprotkb/Q3SZY3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTTG1", "url": "https://www.uniprot.org/uniprotkb/Q3SZY3", "locus": {} } ], "crossref": [ { "id": "Q3SZY3", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZY3", "database": "AlphaFoldDB", "categories": [] }, { "id": "508043", "url": "https://www.ncbi.nlm.nih.gov/gene/508043", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508043", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508043", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3SZY3", "url": "https://www.orthodb.org/?gene=Q3SZY3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10418", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10418", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10418:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10418:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04856", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04856", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029482", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZY3", "url": "https://www.uniprot.org/uniprotkb/Q3SZY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZY3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZY3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTLIYVDKENGEPGIHVAPKDGLKLGSVPSVKALDGRSQVSTPHVGKMFDAPPALPKTARKALGTVNRATEKSVKTNGPLKQKQTTFSTKKITEKTVKAKSSVPASDDTYPEIEKFFPFNPLDFENFDLPEEHQIARLPLSGVPLMILDEERELEQLLHVGPPSPLKMPPLLWESNLLQSPSSILSTLDVELPPVCCDLDI", "length": 202, "header": "sp|Q3SZY3-1|PTTG1_BOVIN Isoform 1 of Securin OS=Bos taurus OX=9913 GN=PTTG1 PE=2 SV=1 CANONICAL=Q3SZY3-1" }, "isoforms": [ { "isoform_ac": "Q3SZY3-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZY3/entry#Q3SZY3-1", "sequence": { "sequence": "MSTLIYVDKENGEPGIHVAPKDGLKLGSVPSVKALDGRSQVSTPHVGKMFDAPPALPKTARKALGTVNRATEKSVKTNGPLKQKQTTFSTKKITEKTVKAKSSVPASDDTYPEIEKFFPFNPLDFENFDLPEEHQIARLPLSGVPLMILDEERELEQLLHVGPPSPLKMPPLLWESNLLQSPSSILSTLDVELPPVCCDLDI", "length": 202, "header": "sp|Q3SZY3-1|PTTG1_BOVIN Isoform 1 of Securin OS=Bos taurus OX=9913 GN=PTTG1 PE=2 SV=1 CANONICAL=Q3SZY3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 165, "end_pos": 165, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CDK1", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY3", "url": "https://www.uniprot.org/uniprotkb/Q3SZY3" } ], "site_lbl": "Ser165" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508043", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508043", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "homologous chromosome segregation", "id": "GO:0045143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045143", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY3", "url": "https://www.uniprot.org/uniprotkb/Q3SZY3" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY3", "url": "https://www.uniprot.org/uniprotkb/Q3SZY3" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY3", "url": "https://www.uniprot.org/uniprotkb/Q3SZY3" } ], "pmid": "" }, { "name": "chromosome organization", "id": "GO:0051276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051276", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY3", "url": "https://www.uniprot.org/uniprotkb/Q3SZY3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY3", "url": "https://www.uniprot.org/uniprotkb/Q3SZY3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY3", "url": "https://www.uniprot.org/uniprotkb/Q3SZY3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY3", "url": "https://www.uniprot.org/uniprotkb/Q3SZY3" } ], "pmid": "" }, { "name": "cysteine-type endopeptidase inhibitor activity", "id": "GO:0004869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004869", "evidence": [ { "database": "UniProtKB", "id": "Q3SZY3", "url": "https://www.uniprot.org/uniprotkb/Q3SZY3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZY3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 202, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZY3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZY3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 165 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { 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"uniprot_canonical_ac": "Q3SZZ7-1", "uniprot_ac": "Q3SZZ7", "uniprot_id": "FGL1_BOVIN", "mass": { "chemical_mass": 36139.0, "monoisotopic_mass": 36139.0 }, "refseq": { "ac": "NP_001029485", "name": "fibrinogen-like protein 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029485" }, "gene_names": [ { "name": "FGL1", "type": "recommended", "evidence": [ { "id": "Q3SZZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7" } ] }, { "name": "FGL1", "type": "synonym", "evidence": [ { "id": "NP_001029485", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029485" } ] } ], "protein_names": [ { "name": "Fibrinogen-like protein 1", "type": "recommended", "evidence": [ { "id": "Q3SZZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7/entry#names_and_taxonomy" } ] }, { "name": "fibrinogen-like protein 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001029485", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029485" } ] }, { "name": "fibrinogen-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001029485", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029485" } ] } ], "function": [ { "annotation": "Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a ligand of LAG3. LAG3-binding initiates a signaling that inhibits the T-cell receptor (TCR) in the immunological synapse, preventing T-cell activation. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes.", "evidence": [ { "database": "UniProtKB", "id": "Q3SZZ7", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7#function" }, { "database": "UniProtKB", "id": "Q08830", "url": "https://www.uniprot.org/uniprotkb/Q08830#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3SZZ7", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FGL1", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7", "locus": { "chromosome": "27", "start_pos": 19406133, "end_pos": 19352369, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016177", "url": "https://www.ensembl.org/id/ENSBTAG00000016177" } ] } } ], "crossref": [ { "id": "Q3SZZ7", "url": "https://alphafold.ebi.ac.uk/entry/Q3SZZ7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016177", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016177", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00087", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00087", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508090", "url": "https://www.ncbi.nlm.nih.gov/gene/508090", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020837", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020837", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508090", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508090", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ASHQGIK", "url": "https://omabrowser.org/oma/group/ASHQGIK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3SZZ7", "url": "https://www.orthodb.org/?gene=Q3SZZ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47221", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47221", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47221:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47221:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00147", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00147", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029485", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3SZZ7", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3SZZ7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKMFSFILVTTALVMGRGSSALENCLQEQARLRAQVYLLETRVKQQQVKISQLLHEKQVQLLDKGEENSVIDLGGKRQYADCSEIFNDGYKQSGFYKIKPLQSPAEFSVYCDMSDGGGWTVIQRRSDGSENFNRDWSDYENGFGNFVQKNGEYWLGNRNLHLLTTQGDYTLKIDLADFEKNSRYAQYKNFKVGDEKNSYDLHIGEYSGTAGDSLTGNFHPEVQWWASHQRMKFSTWDRDNDNYEGNCAKEDQSGWWFNRCHSANLNGFYHKGPYTAKTDNGIVWHTWHGWWYSLKSVVMKIRPNDFIPNIV", "length": 312, "header": "sp|Q3SZZ7-1|FGL1_BOVIN Isoform 1 of Fibrinogen-like protein 1 OS=Bos taurus OX=9913 GN=FGL1 PE=2 SV=1 CANONICAL=Q3SZZ7-1" }, "isoforms": [ { "isoform_ac": "Q3SZZ7-1", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7/entry#Q3SZZ7-1", "sequence": { "sequence": "MAKMFSFILVTTALVMGRGSSALENCLQEQARLRAQVYLLETRVKQQQVKISQLLHEKQVQLLDKGEENSVIDLGGKRQYADCSEIFNDGYKQSGFYKIKPLQSPAEFSVYCDMSDGGGWTVIQRRSDGSENFNRDWSDYENGFGNFVQKNGEYWLGNRNLHLLTTQGDYTLKIDLADFEKNSRYAQYKNFKVGDEKNSYDLHIGEYSGTAGDSLTGNFHPEVQWWASHQRMKFSTWDRDNDNYEGNCAKEDQSGWWFNRCHSANLNGFYHKGPYTAKTDNGIVWHTWHGWWYSLKSVVMKIRPNDFIPNIV", "length": 312, "header": "sp|Q3SZZ7-1|FGL1_BOVIN Isoform 1 of Fibrinogen-like protein 1 OS=Bos taurus OX=9913 GN=FGL1 PE=2 SV=1 CANONICAL=Q3SZZ7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508090", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508090", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BKJ2-1", "protein_name": "Fibrinogen-like protein 1", "gene_name": "FGL1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGKMAKTFSFILLTTALVMVRESWALEEDCLREQARLRAQVHLLETRVKQQKVKILQLLQEKEIQFLDKGEENSVIDLGGKRQYADCSEIFNDGFKQSGFYKIKPLQSPAEFSVYCDMSDGGGWTVIQRRSDGSENFNRNWNDYENGFGNFVQKNGEYWLGNRNLHVLTTQGDYTLKIDLADFEKNNRYAQYKNFKVGDEKNSYDLHIGEYSGTAGDSLAGNFHPEVQWWGSHQRMKFSTWDRDNDNYEGNCAKEDLSGWWFNRCHSANLNGLYHSGPYTAKTDNGIVWHTWHGWWYSLKSVVMKIRPNDFIPNIV", "length": 316 }, "evidence": [ { "id": "Q3SZZ7", "url": "https://omabrowser.org/oma/group/Q3SZZ7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "E1BY61-1", "protein_name": "Fibrinogen-like protein 1", "gene_name": "FGL1A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKILIVIDFLLAASLTSATRSSDLQNCFQEQIQLQAQVRLLEHRVKQQQLKIIQLLEKKEIQYRDRGDENSVIDLGGKRQYSDCAEIYNDGHKKSGFYKMKPTQSPNEFLAFCDMSEGGGWTVFQRRSDGSQDFNRDWTDYEEGFGNFVLTNGEYWLGNKNLHYLTNQGNYTLRIDLSDFEGERRYAQYTRFGVADEEHSYQMSCGEYSGTAGDSLTGGFHPEVKWWADHCGMKFSTRDRDNDNYEGNCAEEEKAGWWFNRCHSANLNGLYYKGPYTAKTDNGVVWYTWHGWWYSLKSVVMKVRPAHFKPNIV", "length": 313 }, "evidence": [ { "id": "Q3SZZ7", "url": "https://omabrowser.org/oma/group/Q3SZZ7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3GZB4-1", "protein_name": "Fibrinogen-like protein 1", "gene_name": "Fgl1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGKIRSFVLVTIALIMSRESWALENVNCLREQERLRAQVHQLETRVKQQQAMIAQLMHEKEVQFLDKGPEDNFIDLGGKRQYADCSEIYNDGFKQSGFYKIKPLQSQASFSVYCDMSDGGGWTVIQRRSDGSENFSRGWNDYENGFGNFVRSNGEYWLGNKNLNLLTMQGDYTLKIDLTDFEKNSRFAQYKHFKVGEKKSFYELNIGEYSGTAGDSLSGTFHPEVQWWASHQRMKFSTWDRDNDNYNGNCAEEEQSGWWFNRCHSANLNGVYYQGPYTAETDNGVVWYTWHGWWYSLKSVVMKIRPNDFIPNII", "length": 314 }, "evidence": [ { "id": "Q3SZZ7", "url": "https://omabrowser.org/oma/group/Q3SZZ7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q08830-1", "protein_name": "Fibrinogen-like protein 1", "gene_name": "FGL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKVFSFILVTTALTMGREISALEDCAQEQMRLRAQVRLLETRVKQQQVKIKQLLQENEVQFLDKGDENTVIDLGSKRQYADCSEIFNDGYKLSGFYKIKPLQSPAEFSVYCDMSDGGGWTVIQRRSDGSENFNRGWKDYENGFGNFVQKHGEYWLGNKNLHFLTTQEDYTLKIDLADFEKNSRYAQYKNFKVGDEKNFYELNIGEYSGTAGDSLAGNFHPEVQWWASHQRMKFSTWDRDHDNYEGNCAEEDQSGWWFNRCHSANLNGVYYSGPYTAKTDNGIVWYTWHGWWYSLKSVVMKIRPNDFIPNVI", "length": 312 }, "evidence": [ { "id": "Q3SZZ7", "url": "https://omabrowser.org/oma/group/Q3SZZ7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5M8C6-1", "protein_name": "Fibrinogen-like protein 1", "gene_name": "Fgl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGEIRSFVLITVALILGKESWVLGDENCLQEQVRLRAQVRQLETRVKQQQVVIAQLLHEKEVQFLDRGQEDSFIDLGGKRHYADCSEIYNDGFKHSGFYKIKPLQSLAEFSVYCDMSDGGGWTVIQRRSDGSENFNRGWNDYENGFGNFVQSNGEYWLGNKNINLLTMQGDYTLKIDLTDFEKNSRFAQYEKFKVGDEKSFYELNIGEYSGTAGDSLSGTFHPEVQWWASHQTMKFSTRDRDNDNYNGNCAEEEQSGWWFNRCHSANLNGVYYQGPYRAETDNGVVWYTWRGWWYSLKSVVMKIRPSDFIPNIV", "length": 314 }, "evidence": [ { "id": "Q3SZZ7", "url": "https://omabrowser.org/oma/group/Q3SZZ7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q71KU9-1", "protein_name": "Fibrinogen-like protein 1", "gene_name": "Fgl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGKIYSFVLVAIALMMGREGWALESESCLREQVRLRAQVHQLETRVKQQQTMIAQLLHEKEVQFLDKGSENSFIDLGGKRQYADCSEIYNDGFKQSGFYKIKPLQSLAEFSVYCDMSDGGGWTVIQRRSDGSENFNRGWNDYENGFGNFVQNNGEYWLGNKNINLLTIQGDYTLKIDLTDFEKNSSFAQYQSFKVGDKKSFYELNIGEYSGTAGDSLSGTFHPEVQWWASHQRMKFSTWDRDNDNYQGNCAEEEQSGWWFNRCHSANLNGVYYRGSYRAETDNGVVWYTWHGWWYSLKSVVMKIRPSDFIPNII", "length": 314 }, "evidence": [ { "id": "Q3SZZ7", "url": "https://omabrowser.org/oma/group/Q3SZZ7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "hepatocyte proliferation", "id": "GO:0072574", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072574", "evidence": [ { "database": "UniProtKB", "id": "Q3SZZ7", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7" } ], "pmid": "" }, { "name": "blood coagulation", "id": "GO:0007596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596", "evidence": [ { "database": "UniProtKB", "id": "Q3SZZ7", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7" } ], "pmid": "" }, { "name": "regulation of immune response", "id": "GO:0050776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050776", "evidence": [ { "database": "UniProtKB", "id": "Q3SZZ7", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7" } ], "pmid": "" }, { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "Q3SZZ7", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7" } ], "pmid": "" }, { "name": "negative regulation of T cell activation", "id": "GO:0050868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050868", "evidence": [ { "database": "UniProtKB", "id": "Q3SZZ7", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q3SZZ7", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q3SZZ7", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "Q3SZZ7", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3SZZ7", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7" } ], "pmid": "" }, { "name": "receptor ligand activity", "id": "GO:0048018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048018", "evidence": [ { "database": "UniProtKB", "id": "Q3SZZ7", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3SZZ7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 312, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3SZZ7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3SZZ7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3SZZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7" }, { "id": "PRU00739", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00739" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibrinogen C-terminal", "eco_id": "ECO_0000255", "start_pos": 74, "end_pos": 306, "start_aa": "Leu", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "Q3SZZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7#function" }, { "id": "Q3SZZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7" } ], "binding_site_uniprot": 240, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 240, "end_pos": 240, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3SZZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7#function" }, { "id": "Q3SZZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZZ7" } ], "binding_site_uniprot": 242, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", 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246, "end_pos": 246, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T022-1", "uniprot_ac": "Q3T022", "uniprot_id": "SAP18_BOVIN", "mass": { "chemical_mass": 17579.0, "monoisotopic_mass": 17579.0 }, "refseq": { "ac": "NP_001030544", "name": "histone deacetylase complex subunit SAP18", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030544" }, "gene_names": [ { "name": "SAP18", "type": "recommended", "evidence": [ { "id": "Q3T022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T022" } ] }, { "name": "SAP18", "type": "synonym", "evidence": [ { "id": "NP_001030544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030544" } ] } ], "protein_names": [ { "name": "Histone deacetylase complex subunit SAP18", "type": "recommended", "evidence": [ { "id": "Q3T022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T022/entry#names_and_taxonomy" } ] }, { "name": "18 kDa Sin3-associated polypeptide", "type": "synonym", "evidence": [ { "id": "NP_001030544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030544" }, { "id": "Q3T022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T022/entry#names_and_taxonomy" } ] }, { "name": "Sin3-associated polypeptide p18", "type": "synonym", "evidence": [ { "id": "Q3T022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T022/entry#names_and_taxonomy" } ] }, { "name": "Sin3A-associated protein, 18kDa", "type": "synonym", "evidence": [ { "id": "NP_001030544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030544" } ] }, { "name": "histone deacetylase complex subunit SAP18", "type": "synonym", "evidence": [ { "id": "NP_001030544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030544" } ] }, { "name": "sin3-associated polypeptide p18", "type": "synonym", "evidence": [ { "id": "NP_001030544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030544" } ] }, { "name": "sin3-associated polypeptide, 18 kDa", "type": "synonym", "evidence": [ { "id": "NP_001030544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030544" } ] }, { "name": "sin3-associated polypeptide, 18kDa", "type": "synonym", "evidence": [ { "id": "NP_001030544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030544" } ] } ], "function": [ { "annotation": "Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T022", "url": "https://www.uniprot.org/uniprotkb/Q3T022#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T022", "url": "https://www.uniprot.org/uniprotkb/Q3T022" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SAP18", "url": "https://www.uniprot.org/uniprotkb/Q3T022", "locus": { "chromosome": "12", "start_pos": 35603044, "end_pos": 35610878, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018631", "url": 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"OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13082", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13082", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13082:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13082:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06487", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06487", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030544", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T022", "url": "https://www.uniprot.org/uniprotkb/Q3T022", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T022-1", "url": "https://www.uniprot.org/uniprotkb/Q3T022-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVESRVTQEEIKKEPEKPIDREKTCPLLLRVFTTNNGRHHRMDEFSRGNVPSSELQIYTWMDATLKELTSLVKEVYPEARKKGTHFNFAIVFTDLKRPGYRVKEIGSTMSGRKGTDDSMTLQSQKFQIGDYLDIAITPPNRAPPTSGRMRPY", "length": 153, "header": "sp|Q3T022-1|SAP18_BOVIN Isoform 1 of Histone deacetylase complex subunit SAP18 OS=Bos taurus OX=9913 GN=SAP18 PE=2 SV=1 CANONICAL=Q3T022-1" }, "isoforms": [ { "isoform_ac": "Q3T022-1", "url": "https://www.uniprot.org/uniprotkb/Q3T022/entry#Q3T022-1", "sequence": { "sequence": "MAVESRVTQEEIKKEPEKPIDREKTCPLLLRVFTTNNGRHHRMDEFSRGNVPSSELQIYTWMDATLKELTSLVKEVYPEARKKGTHFNFAIVFTDLKRPGYRVKEIGSTMSGRKGTDDSMTLQSQKFQIGDYLDIAITPPNRAPPTSGRMRPY", "length": 153, "header": "sp|Q3T022-1|SAP18_BOVIN Isoform 1 of Histone deacetylase complex subunit SAP18 OS=Bos taurus OX=9913 GN=SAP18 PE=2 SV=1 CANONICAL=Q3T022-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3T022", "url": "https://www.uniprot.org/uniprotkb/Q3T022" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "Q3T022", "url": "https://www.uniprot.org/uniprotkb/Q3T022" } ], "pmid": "" }, { "name": "ASAP complex", "id": "GO:0061574", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061574", "evidence": [ { "database": "UniProtKB", "id": "Q3T022", "url": "https://www.uniprot.org/uniprotkb/Q3T022" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3T022", "url": "https://www.uniprot.org/uniprotkb/Q3T022" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "Q3T022", "url": "https://www.uniprot.org/uniprotkb/Q3T022" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "Q3T022", "url": "https://www.uniprot.org/uniprotkb/Q3T022" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "Q3T022", "url": "https://www.uniprot.org/uniprotkb/Q3T022" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "Q3T022", "url": "https://www.uniprot.org/uniprotkb/Q3T022" } ], "pmid": "" }, { "name": "negative regulation of mRNA splicing, via spliceosome", "id": "GO:0048025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048025", "evidence": [ { "database": "UniProtKB", "id": "Q3T022", "url": "https://www.uniprot.org/uniprotkb/Q3T022" } ], "pmid": "" }, { "name": "regulation of alternative mRNA splicing, via spliceosome", "id": "GO:0000381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000381", "evidence": [ { "database": "UniProtKB", "id": "Q3T022", "url": "https://www.uniprot.org/uniprotkb/Q3T022" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "Q3T022", "url": "https://www.uniprot.org/uniprotkb/Q3T022" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": 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"start_pos": 21, "end_pos": 21, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T030", "url": "https://www.uniprot.org/uniprotkb/Q3T030" } ], "site_lbl": "Ser21" }, { "start_pos": 25, "end_pos": 25, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3T030", "url": "https://www.uniprot.org/uniprotkb/Q3T030" } ], "site_lbl": "Thr25" }, { "start_pos": 28, "end_pos": 28, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T030", "url": "https://www.uniprot.org/uniprotkb/Q3T030" } ], "site_lbl": "Ser28" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510029", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510029", "resource": 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"id": "R-BTA-174178", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174178", "resource": "Reactome", "description": "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" }, { "id": "R-BTA-174184", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174184", "resource": "Reactome", "description": "Cdc20:Phospho-APC/C mediated degradation of Cyclin A" }, { "id": "R-BTA-187577", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-187577", "resource": "Reactome", "description": "SCF(Skp2)-mediated degradation of p27/p21" }, { "id": "R-BTA-195253", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-195253", "resource": "Reactome", "description": "Degradation of beta-catenin by the destruction complex" }, { "id": "R-BTA-202424", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202424", "resource": "Reactome", "description": "Downstream TCR signaling" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2871837", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2871837", "resource": "Reactome", "description": "FCERI mediated NF-kB activation" }, { "id": "R-BTA-349425", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-349425", "resource": "Reactome", "description": "Autodegradation of the E3 ubiquitin ligase COP1" }, { "id": "R-BTA-350562", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-350562", "resource": "Reactome", "description": "Regulation of ornithine decarboxylase (ODC)" }, { "id": "R-BTA-382556", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-382556", "resource": "Reactome", "description": "ABC-family protein mediated transport" }, { "id": "R-BTA-450408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450408", "resource": "Reactome", "description": "AUF1 (hnRNP D0) binds and destabilizes mRNA" }, { "id": "R-BTA-4608870", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4608870", "resource": "Reactome", "description": "Asymmetric localization of PCP proteins" }, { "id": "R-BTA-4641257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641257", "resource": "Reactome", "description": "Degradation of AXIN" }, { "id": "R-BTA-4641258", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641258", "resource": "Reactome", "description": "Degradation of DVL" }, { "id": "R-BTA-5358346", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5358346", "resource": "Reactome", "description": "Hedgehog ligand biogenesis" }, { "id": "R-BTA-5607761", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5607761", "resource": "Reactome", "description": "Dectin-1 mediated 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"https://www.reactome.org/PathwayBrowser/#R-BTA-5676590", "resource": "Reactome", "description": "NIK-->noncanonical NF-kB signaling" }, { "id": "R-BTA-5687128", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5687128", "resource": "Reactome", "description": "MAPK6/MAPK4 signaling" }, { "id": "R-BTA-5689603", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689603", "resource": "Reactome", "description": "UCH proteinases" }, { "id": "R-BTA-5689880", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689880", "resource": "Reactome", "description": "Ub-specific processing proteases" }, { "id": "R-BTA-68867", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68867", "resource": "Reactome", "description": "Assembly of the pre-replicative complex" }, { "id": "R-BTA-68949", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68949", "resource": "Reactome", "description": "Orc1 removal from chromatin" }, { "id": "R-BTA-69017", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69017", "resource": "Reactome", "description": "CDK-mediated phosphorylation and removal of Cdc6" }, { "id": "R-BTA-69481", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69481", "resource": "Reactome", "description": "G2/M Checkpoints" }, { "id": "R-BTA-69601", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69601", "resource": "Reactome", "description": "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A" }, { "id": "R-BTA-75815", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75815", "resource": "Reactome", "description": "Ubiquitin-dependent degradation of Cyclin D" }, { "id": "R-BTA-8852276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8852276", "resource": "Reactome", "description": "The role of GTSE1 in G2/M progression after G2 checkpoint" }, { "id": "R-BTA-8854050", "name": "", "url": 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Proteasome degradation" }, { "id": "R-BTA-9907900", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9907900", "resource": "Reactome", "description": "Proteasome assembly" }, { "id": "R-BTA-9929356", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9929356", "resource": "Reactome", "description": "GSK3B-mediated proteasomal degradation of PD-L1(CD274)" }, { "id": "R-BTA-9929491", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9929491", "resource": "Reactome", "description": "SPOP-mediated proteasomal degradation of PD-L1(CD274)" }, { "id": "R-BTA-9931269", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931269", "resource": "Reactome", "description": "AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)" }, { "id": "R-BTA-9932298", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9932298", "resource": "Reactome", "description": "Degradation of CRY and PER proteins" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1SRU3-1", "protein_name": "26S proteasome regulatory subunit 6B", "gene_name": "PSMC4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK", "length": 418 }, "evidence": [ { "id": "Q3T030", "url": "https://omabrowser.org/oma/group/Q3T030/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "B0R1D0-1", "protein_name": "26S proteasome regulatory subunit 6B", "gene_name": "psmc4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEDGGVLVEKPQDDVPALLNSRPQTGLSFLAPEPEDLEDLYSIYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVLYSDIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLVFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQEAGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK", "length": 418 }, "evidence": [ { "id": "Q3T030", "url": "https://omabrowser.org/oma/group/Q3T030/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P33298-1", "protein_name": "26S proteasome regulatory subunit 6B homolog", "gene_name": "RPT3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MEELGIVTPVEKAVEEKPAVKSYASLLAQLNGTVNNNSALSNVNSDIYFKLKKLEKEYELLTLQEDYIKDEQRHLKRELKRAQEEVKRIQSVPLVIGQFLEPIDQNTGIVSSTTGMSYVVRILSTLDRELLKPSMSVALHRHSNALVDILPPDSDSSISVMGENEKPDVTYADVGGLDMQKQEIREAVELPLVQADLYEQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTKAAFIRVNGSEFVHKYLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRFDAQTGSDREVQRILIELLTQMDGFDQSTNVKVIMATNRADTLDPALLRPGRLDRKIEFPSLRDRRERRLIFGTIASKMSLAPEADLDSLIIRNDSLSGAVIAAIMQEAGLRAVRKNRYVILQSDLEEAYATQVKTDNTVDKFDFYK", "length": 428 }, "evidence": [ { "id": "Q3T030", "url": "https://omabrowser.org/oma/group/Q3T030/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P34123-1", "protein_name": "26S proteasome regulatory subunit 6B homolog", "gene_name": "psmC4", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEELGLATAKVTVTKEASHHREADLYQKMKSLESKLDFFNIQEEYIKYEYKNLKRELLHAQEEVKRIRSVPLLIGQLLEMVDSNTGIVQSTSGSTLCVRILSTIDRELLKPSASVALQRHSNALVDTLPPESDSSIHLLGADEKPSESYSDIGGGDIQKQEMREAVELPLTHHNLYKQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTSAAFIRVVGSEFVQKYLGEGPRLVRDVFRLARENSPAIIFIDEIDAIATKRFDAQTGADREVQRILMELLNQMDGFDVSVNVKVIMATNRQDTLDPALLRPGRLDRKIEFPLPDRRQKRLIFQVITSKMNLSDEVDLEDYVSRPDKLSGAEIQSICQEAGMHAIRKNRYVILPKDFEKGYKASIKKNTHEFNFYN", "length": 403 }, "evidence": [ { "id": "Q3T030", "url": "https://omabrowser.org/oma/group/Q3T030/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "P43686-1", "protein_name": "26S proteasome regulatory subunit 6B", "gene_name": "PSMC4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK", "length": 418 }, "evidence": [ { "id": "Q3T030", "url": "https://omabrowser.org/oma/group/Q3T030/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P54775-1", "protein_name": "26S proteasome regulatory subunit 6B", "gene_name": "Psmc4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEIGILVEKIQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK", "length": 418 }, "evidence": [ { "id": "Q3T030", "url": "https://omabrowser.org/oma/group/Q3T030/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q63570-1", "protein_name": "26S proteasome regulatory subunit 6B", "gene_name": "Psmc4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEEIGILVEKIQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK", "length": 418 }, "evidence": [ { "id": "Q3T030", "url": "https://omabrowser.org/oma/group/Q3T030/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9SEI4-1", "protein_name": "26S proteasome regulatory subunit 6B homolog", "gene_name": "RPT3", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MASAAVASMVLDPKASPALMDLSTADEEDLYGRLKSLERQLEFTDIQEEYVKDEQKNLKRELLRAQEEVKRIQSVPLVIGQFMEMVDQNNGIVGSTTGSNYYVRILSTINRELLKPSASVALHRHSNALVDVLPPEADSSISLLSQSEKPDVSYNDIGGCDIQKQEIREAVELPLTHHELYKQIGIDPPRGVLLYGPPGTGKTMLAKAVANHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEVDAIATARFDAQTGADREVQRILMELLNQMDGFDQTVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLVFQVCTSKMNLSDEVDLEDYVSRPDKISAAEIAAICQEAGMHAVRKNRYVILPKDFEKGYRANVKKPDTDFEFYK", "length": 408 }, "evidence": [ { "id": "Q3T030", "url": "https://omabrowser.org/oma/group/Q3T030/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9V405-1", "protein_name": "26S proteasome regulatory subunit 6B", "gene_name": "Rpt3", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPYNMDVLIPEKDELSDLKLKDAHSSLDELDMEDLYVRYKKLQKTLEFIEVQEEYIKDEQRNLKKEYLHAQEEVKRIQSVPLVIGQFLEAVDQNTGIVGSTTGSNYYVRILSTIDRELLKPSASVALHKHSNALVDVLPPEADSSISMLQPDEKPDVSYADIGGMDMQKQEIREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTASFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTTNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLVFSTITSKMNLSEDVDLEEFVARPDKISGADINAICQEAGMHAVRENRYIVLAKDFEKGYKNNIKKDEQEHEFYK", "length": 413 }, "evidence": [ { "id": "Q3T030", "url": "https://omabrowser.org/oma/group/Q3T030/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "proteasome regulatory particle, base subcomplex", "id": "GO:0008540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008540", "evidence": [ { "database": "UniProtKB", "id": "Q3T030", "url": "https://www.uniprot.org/uniprotkb/Q3T030" } ], "pmid": "" }, { "name": "proteasome accessory complex", "id": "GO:0022624", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022624", "evidence": [ { "database": "UniProtKB", "id": "Q3T030", "url": "https://www.uniprot.org/uniprotkb/Q3T030" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3T030", "url": "https://www.uniprot.org/uniprotkb/Q3T030" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3T030", "url": "https://www.uniprot.org/uniprotkb/Q3T030" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q3T030", "url": "https://www.uniprot.org/uniprotkb/Q3T030" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q3T030", "url": "https://www.uniprot.org/uniprotkb/Q3T030" } ], "pmid": "" }, { "name": "proteasome-activating activity", "id": "GO:0036402", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036402", "evidence": [ { "database": "UniProtKB", "id": "Q3T030", "url": "https://www.uniprot.org/uniprotkb/Q3T030" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q3T030", "url": "https://www.uniprot.org/uniprotkb/Q3T030" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 353, "end_pos": 355, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": 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"table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T042-1", "uniprot_ac": "Q3T042", "uniprot_id": "NOB1_BOVIN", "mass": { "chemical_mass": 46563.0, "monoisotopic_mass": 46563.0 }, "refseq": { "ac": "NP_898906", "name": "RNA-binding protein NOB1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898906" }, "gene_names": [ { "name": "NOB1", "type": "recommended", "evidence": [ { "id": "Q3T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T042" } ] }, { "name": "NOB1P", "type": "synonym", "evidence": [ { "id": "NP_898906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898906" } ] }, { "name": "NOB1", "type": "synonym", "evidence": [ { "id": "NP_898906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898906" } ] } ], "protein_names": [ { "name": "RNA-binding protein NOB1", "type": "recommended", "evidence": [ { "id": "Q3T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T042/entry#names_and_taxonomy" } ] }, { "name": "3.1.-.-", "type": "synonym", "evidence": [ { "id": "Q3T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T042/entry#names_and_taxonomy" } ] }, { "name": "NIN1/PSMD8 binding protein 1 homolog", "type": "synonym", "evidence": [ { "id": "NP_898906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898906" } ] }, { "name": "RNA-binding protein NOB1", "type": "synonym", "evidence": [ { "id": "NP_898906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898906" } ] } ], "function": [ { "annotation": "May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T042", "url": "https://www.uniprot.org/uniprotkb/Q3T042#function" }, { "database": "UniProtKB", "id": "Q9ULX3", "url": "https://www.uniprot.org/uniprotkb/Q9ULX3#function" }, { "database": "UniProtKB", "id": "Q9FLL1", "url": "https://www.uniprot.org/uniprotkb/Q9FLL1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T042", "url": "https://www.uniprot.org/uniprotkb/Q3T042" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NOB1", "url": "https://www.uniprot.org/uniprotkb/Q3T042", "locus": { "chromosome": "18", "start_pos": 36812458, "end_pos": 36829147, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020633", "url": "https://www.ensembl.org/id/ENSBTAG00000020633" } ] } } ], "crossref": [ { "id": "Q3T042", "url": "https://alphafold.ebi.ac.uk/entry/Q3T042", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd09876", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09876", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "360191", "url": "https://www.ncbi.nlm.nih.gov/gene/360191", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017117", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017117", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033411", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033411", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033461", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033461", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:360191", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:360191", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T042", "url": "https://www.orthodb.org/?gene=Q3T042", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12814", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12814", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12814:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12814:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08772", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08772", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17146", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17146", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_898906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898906", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T042", "url": "https://www.uniprot.org/uniprotkb/Q3T042", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T042-1", "url": "https://www.uniprot.org/uniprotkb/Q3T042-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPVEHVVADAGAFLLDAALQDIGKNIYTIRNVISEIRDKATRRRLAVLPYELRFKEPFPEYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKQEPEKVKVSSSIQHPETPLHVSGFHLPSKPKPPRETVEHRHPASEPEDLEFSSFMFWRNPLPNIDCELQELLMDGGEDVPNEEEDEENGLDERQDEDSDDDGGGWITPSNIKQIQQEMKQCAVPKDVRVGCVTTDFAMQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKTTSDMSRVFCAHCGNKTLKKVSVTVSDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAINPHLTEDQRFPQLRLSRKARQKTDVFAPDYVAGVSPFAENDISSRSATLQVRDSTLGAGRRRLNPNASRKKFVKKR", "length": 413, "header": "sp|Q3T042-1|NOB1_BOVIN Isoform 1 of RNA-binding protein NOB1 OS=Bos taurus OX=9913 GN=NOB1 PE=2 SV=1 CANONICAL=Q3T042-1" }, "isoforms": [ { "isoform_ac": "Q3T042-1", "url": "https://www.uniprot.org/uniprotkb/Q3T042/entry#Q3T042-1", "sequence": { "sequence": "MAPVEHVVADAGAFLLDAALQDIGKNIYTIRNVISEIRDKATRRRLAVLPYELRFKEPFPEYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKQEPEKVKVSSSIQHPETPLHVSGFHLPSKPKPPRETVEHRHPASEPEDLEFSSFMFWRNPLPNIDCELQELLMDGGEDVPNEEEDEENGLDERQDEDSDDDGGGWITPSNIKQIQQEMKQCAVPKDVRVGCVTTDFAMQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKTTSDMSRVFCAHCGNKTLKKVSVTVSDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAINPHLTEDQRFPQLRLSRKARQKTDVFAPDYVAGVSPFAENDISSRSATLQVRDSTLGAGRRRLNPNASRKKFVKKR", "length": 413, "header": "sp|Q3T042-1|NOB1_BOVIN Isoform 1 of RNA-binding protein NOB1 OS=Bos taurus OX=9913 GN=NOB1 PE=2 SV=1 CANONICAL=Q3T042-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 202, "end_pos": 202, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T042", "url": "https://www.uniprot.org/uniprotkb/Q3T042" } ], "site_lbl": "Ser202" }, { "start_pos": 326, "end_pos": 326, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T042", "url": "https://www.uniprot.org/uniprotkb/Q3T042" } ], "site_lbl": "Ser326" }, { "start_pos": 353, "end_pos": 353, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T042", "url": "https://www.uniprot.org/uniprotkb/Q3T042" } ], "site_lbl": "Ser353" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:360191", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:360191", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3T042", "url": "https://www.uniprot.org/uniprotkb/Q3T042" } ], "pmid": "" }, { 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"count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T058-1", "uniprot_ac": "Q3T058", "uniprot_id": "EI2BD_BOVIN", "mass": { "chemical_mass": 57469.0, "monoisotopic_mass": 57469.0 }, "refseq": { "ac": "NP_001029716", "name": "translation initiation factor eIF2B subunit delta", "summary": "", "url": 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initiation factor 2 (eIF2) gamma subunit. 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"end_pos": 72292939, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019510", "url": "https://www.ensembl.org/id/ENSBTAG00000019510" } ] } } ], "crossref": [ { "id": "Q3T058", "url": "https://alphafold.ebi.ac.uk/entry/Q3T058", "database": "AlphaFoldDB", "categories": [] }, { "id": "521926", "url": "https://www.ncbi.nlm.nih.gov/gene/521926", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000649", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000649", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037171", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037171", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042529", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042529", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521926", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521926", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T058", "url": "https://www.orthodb.org/?gene=Q3T058", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10233", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10233", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10233:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10233:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01008", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01008", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029716", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T058", "url": "https://www.uniprot.org/uniprotkb/Q3T058", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T058-1", "url": "https://www.uniprot.org/uniprotkb/Q3T058-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATAAVAVREDSGSGMKAELAPRPGAEGREMTQEEKLQLRKEKKQQKKKRKEEKGTETETGSAVSAAQCQVGPAKHLAGPDSQLGTAKEKVPAGRSKAELRAERRAKQEAERAMKQARKGDQGGPPPQACPSTAGETPSGVKRLPEHSQVDDPTLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQYSRQNSLTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYTTPPSEELSRDLVNKLKPYFSFLTQCRPLSASMYNAIKLLNKEITGVSGSKREEEAKSELRAAIDRYIKEKIVLAAQAISRFAYKKISNGDVILVYGCSSLVSHILQEAWAKGRQFRVVVVDSRPRLEAKHTLRSLVRAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLLCERGEHVALANWQNHSSLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ", "length": 524, "header": "sp|Q3T058-1|EI2BD_BOVIN Isoform 1 of Translation initiation factor eIF2B subunit delta OS=Bos taurus OX=9913 GN=EIF2B4 PE=2 SV=1 CANONICAL=Q3T058-1" }, "isoforms": [ { "isoform_ac": "Q3T058-1", "url": "https://www.uniprot.org/uniprotkb/Q3T058/entry#Q3T058-1", "sequence": { "sequence": "MATAAVAVREDSGSGMKAELAPRPGAEGREMTQEEKLQLRKEKKQQKKKRKEEKGTETETGSAVSAAQCQVGPAKHLAGPDSQLGTAKEKVPAGRSKAELRAERRAKQEAERAMKQARKGDQGGPPPQACPSTAGETPSGVKRLPEHSQVDDPTLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQYSRQNSLTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYTTPPSEELSRDLVNKLKPYFSFLTQCRPLSASMYNAIKLLNKEITGVSGSKREEEAKSELRAAIDRYIKEKIVLAAQAISRFAYKKISNGDVILVYGCSSLVSHILQEAWAKGRQFRVVVVDSRPRLEAKHTLRSLVRAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLLCERGEHVALANWQNHSSLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ", "length": 524, "header": "sp|Q3T058-1|EI2BD_BOVIN Isoform 1 of Translation initiation factor eIF2B subunit delta OS=Bos taurus OX=9913 GN=EIF2B4 PE=2 SV=1 CANONICAL=Q3T058-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 493, "start_aa": "Thr", "end_pos": 493, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr493", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 12, "end_pos": 12, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T058", "url": "https://www.uniprot.org/uniprotkb/Q3T058" } ], "site_lbl": "Ser12" }, { "start_pos": 86, "end_pos": 86, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3T058", "url": "https://www.uniprot.org/uniprotkb/Q3T058" } ], "site_lbl": "Thr86" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:521926", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521926", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "cytoplasmic translational initiation", "id": "GO:0002183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002183", "evidence": [ { "database": "UniProtKB", "id": "Q3T058", "url": "https://www.uniprot.org/uniprotkb/Q3T058" } ], "pmid": "" }, { "name": "myelination", "id": "GO:0042552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042552", "evidence": [ { "database": "UniProtKB", "id": "Q3T058", "url": "https://www.uniprot.org/uniprotkb/Q3T058" } ], "pmid": "" }, { "name": "T cell receptor signaling pathway", "id": "GO:0050852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852", "evidence": [ { "database": "UniProtKB", "id": "Q3T058", "url": "https://www.uniprot.org/uniprotkb/Q3T058" } ], "pmid": "" }, { "name": "translational initiation", "id": "GO:0006413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006413", "evidence": [ { "database": "UniProtKB", "id": "Q3T058", "url": "https://www.uniprot.org/uniprotkb/Q3T058" } ], "pmid": "" }, { "name": "ovarian follicle development", "id": "GO:0001541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001541", "evidence": [ { "database": "UniProtKB", "id": "Q3T058", "url": "https://www.uniprot.org/uniprotkb/Q3T058" } ], "pmid": "" }, { "name": "oligodendrocyte development", "id": "GO:0014003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014003", "evidence": [ { "database": "UniProtKB", "id": "Q3T058", "url": "https://www.uniprot.org/uniprotkb/Q3T058" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3T058", "url": "https://www.uniprot.org/uniprotkb/Q3T058" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": 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], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 412, "end_pos": 414, "annotation": "n_glycosylation_sequon" }, { "start_pos": 479, "end_pos": 481, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T058-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 524, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T058-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T058" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 493 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 12, 86 ], "sequon_annotation_sites": [ { "start_pos": 412, "end_pos": 414 }, { "start_pos": 479, "end_pos": 481 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { 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"phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T062-1", "uniprot_ac": "Q3T062", "uniprot_id": "RRP15_BOVIN", "mass": { "chemical_mass": 31491.0, "monoisotopic_mass": 31491.0 }, "refseq": { "ac": "NP_001035596", "name": "RRP15-like protein", 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"https://www.uniprot.org/uniprotkb/Q3T062/entry#names_and_taxonomy" } ] }, { "name": "ribosomal RNA-processing protein 15", "type": "synonym", "evidence": [ { "id": "NP_001035596", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035596" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T062", "url": "https://www.uniprot.org/uniprotkb/Q3T062" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RRP15", "url": "https://www.uniprot.org/uniprotkb/Q3T062", "locus": { "chromosome": "16", "start_pos": 21791045, "end_pos": 21737425, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009838", "url": "https://www.ensembl.org/id/ENSBTAG00000009838" } ] } } ], "crossref": [ { "id": "Q3T062", "url": "https://alphafold.ebi.ac.uk/entry/Q3T062", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009838", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009838", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505387", "url": "https://www.ncbi.nlm.nih.gov/gene/505387", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012459", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012459", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505387", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505387", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FVKQRFY", "url": "https://omabrowser.org/oma/group/FVKQRFY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T062", "url": "https://www.orthodb.org/?gene=Q3T062", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13245", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13245", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13245:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13245:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07890", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07890", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035596", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T062", "url": "https://www.uniprot.org/uniprotkb/Q3T062", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T062-1", "url": "https://www.uniprot.org/uniprotkb/Q3T062-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAVGDSRVSAGKKLKISLRKKRMKMVVASVASELEDKDKDASDNEGSLGSCGLEKDHFSSGDEAVEADNEDEAEPREDDNDSAAEATAGANAGWADAMARILSKKIPESKPTILVRNKELEKEKEKLKQERLEKRKQLDKKREWEMMCRVKPDVVKDKETERNLQRIATRGVVQLFNAVQKHQKNVDEKVKEAGGSIRKRAKLISSVSKKDFISVLRGMDGSASEKNSAGKNSKAKQTEAKSEEGPGWTILRDDFMMGASMKDWDKESDGPDGSRLGCGSDSDT", "length": 286, "header": "sp|Q3T062-1|RRP15_BOVIN Isoform 1 of RRP15-like protein OS=Bos taurus OX=9913 GN=RRP15 PE=2 SV=1 CANONICAL=Q3T062-1" }, "isoforms": [ { "isoform_ac": "Q3T062-1", "url": "https://www.uniprot.org/uniprotkb/Q3T062/entry#Q3T062-1", "sequence": { "sequence": "MAAAVGDSRVSAGKKLKISLRKKRMKMVVASVASELEDKDKDASDNEGSLGSCGLEKDHFSSGDEAVEADNEDEAEPREDDNDSAAEATAGANAGWADAMARILSKKIPESKPTILVRNKELEKEKEKLKQERLEKRKQLDKKREWEMMCRVKPDVVKDKETERNLQRIATRGVVQLFNAVQKHQKNVDEKVKEAGGSIRKRAKLISSVSKKDFISVLRGMDGSASEKNSAGKNSKAKQTEAKSEEGPGWTILRDDFMMGASMKDWDKESDGPDGSRLGCGSDSDT", "length": 286, "header": "sp|Q3T062-1|RRP15_BOVIN Isoform 1 of RRP15-like protein OS=Bos taurus OX=9913 GN=RRP15 PE=2 SV=1 CANONICAL=Q3T062-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 11, "end_pos": 11, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T062", "url": "https://www.uniprot.org/uniprotkb/Q3T062" } ], "site_lbl": "Ser11" }, { "start_pos": 210, "end_pos": 210, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T062", "url": "https://www.uniprot.org/uniprotkb/Q3T062" } ], "site_lbl": "Ser210" }, { "start_pos": 270, "end_pos": 270, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T062", "url": "https://www.uniprot.org/uniprotkb/Q3T062" } ], "site_lbl": "Ser270" }, { "start_pos": 284, "end_pos": 284, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T062", "url": "https://www.uniprot.org/uniprotkb/Q3T062" } ], "site_lbl": "Ser284" }, { "start_pos": 62, "end_pos": 62, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T062", "url": "https://www.uniprot.org/uniprotkb/Q3T062" } ], "site_lbl": "Ser62" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505387", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505387", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YN72-1", "protein_name": "RRP15-like protein", "gene_name": "RRP15", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAAVESSRGQAAAGEEAASDSEISSGLPDDSYSSGDEALDGDDEDEAAVVEHVAEETANSKAGPGSGWADAMAKVLNKKIPQNKSIILAKSKKLEKEREKERQERLEKRRKLDKKREWEMMCRVKPDVVKDRDRERNLQRIATRGVVQLFNAVRTHQKNVDEKVKKGARSERQRAKLLSSVSKKDFINVLRSMEGAKGNRNSARKAAKSKQGEVKSEEGPEWNILRDDFMMGASMKDWDKESDGEGNIEQGGGLKQEDGSD", "length": 262 }, "evidence": [ { "id": "Q3T062", "url": "https://omabrowser.org/oma/group/Q3T062/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q06511-1", "protein_name": "Ribosomal RNA-processing protein 15", "gene_name": "RRP15", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MGSKHRVDTKDKKRTRKNAEFGREKRNSGNQELSNEPEKDTIMEGDEAEEDEQNSSSDESSKIIDNEQSDAEEDDDEEEEDDDFPRKKKSKNSKHDDGSTGFSAAVNAILSSHLKAYDRKDPIMARNKKVLKQSESEKLEYKAKKALLAEKKKLLGKARKTDIIPIASGEDRSENIRKVLEKETALRKIAQKGAVKLFNAILATQVKTEKEVSENLSEIKNKEEKKELITEVSKEKFLDLVKAAAGSDNE", "length": 250 }, "evidence": [ { "id": "Q3T062", "url": "https://omabrowser.org/oma/group/Q3T062/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q5M947-1", "protein_name": "RRP15-like protein", "gene_name": "Rrp15", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAVQDSRVNPGGKLKRSPKKKKKMKKVAKAAVSKLEDELKDSSGGEGSCESEMDDSDDGAAEADSEDNVESCEEENEVAAESSAGTNSGWADAMAKILNKKTPKSKPTILTKNKELEKEKEKLKQERLEKRKQIDKKREWEMLCRVKPDVIKDKEAERNLQRIATRGVVQLFNAVQKHQRNVDEKVKEVGGSIRKRAKLMSTVSKKDFISVLRGMDGASENSSAGKSPKARQTEVKSEEGPGWKILRDDFMMGASMKDWDKESEGEEPADGQAGSASH", "length": 280 }, "evidence": [ { "id": "Q3T062", "url": "https://omabrowser.org/oma/group/Q3T062/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CYX7-1", "protein_name": "RRP15-like protein", "gene_name": "Rrp15", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAVQDSRVSPGEILKRSPKKKKKMKMVAKAAASKLEDEVKDSSDGEGSCDSEMDHSDDGAAEADSEDNVESCEEDNEDAAESSAGTNSGWADAMAKILNKKTPKSKATILTKNKELEKEKEKLKQERLEKRKQLDKKREWEMLCRVKPDVVKDKEAERNLQRIATRGVVQLFNAVQKHQRNVGEKVKEAGGSVRKRAKLMSTVSKKDFISVLRGMDGTSRNSPAGKSPKARQTEVKSEESPGWKILRDDFMMGASMKDWDKESEGEEPAGGRAEAAASR", "length": 281 }, "evidence": [ { "id": "Q3T062", "url": "https://omabrowser.org/oma/group/Q3T062/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y3B9-1", "protein_name": "RRP15-like protein", "gene_name": "RRP15", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAAPDSRVSEEENLKKTPKKKMKMVTGAVASVLEDEATDTSDSEGSCGSEKDHFYSDDDAIEADSEGDAEPCDKENENDGESSVGTNMGWADAMAKVLNKKTPESKPTILVKNKKLEKEKEKLKQERLEKIKQRDKRLEWEMMCRVKPDVVQDKETERNLQRIATRGVVQLFNAVQKHQKNVDEKVKEAGSSMRKRAKLISTVSKKDFISVLRGMDGSTNETASSRKKPKAKQTEVKSEEGPGWTILRDDFMMGASMKDWDKESDGPDDSRPESASDSDT", "length": 282 }, "evidence": [ { "id": "Q3T062", "url": "https://omabrowser.org/oma/group/Q3T062/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "preribosome, large subunit precursor", "id": "GO:0030687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030687", "evidence": [ { "database": "UniProtKB", "id": "Q3T062", "url": "https://www.uniprot.org/uniprotkb/Q3T062" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "maturation of 5.8S rRNA", "id": "GO:0000460", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000460", "evidence": [ { "database": "UniProtKB", "id": "Q3T062", "url": "https://www.uniprot.org/uniprotkb/Q3T062" } ], "pmid": "" }, { "name": "maturation of LSU-rRNA", "id": "GO:0000470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000470", "evidence": [ { "database": "UniProtKB", "id": "Q3T062", "url": "https://www.uniprot.org/uniprotkb/Q3T062" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T062-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 286, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T062-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T062" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 11, 62, 210, 270, 284 ], "sequon_annotation_sites": [ { "start_pos": 82, "end_pos": 84 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T063-1", "uniprot_ac": "Q3T063", "uniprot_id": "NADC_BOVIN", "mass": { "chemical_mass": 31151.0, "monoisotopic_mass": 31151.0 }, "refseq": { "ac": "NP_001030523", "name": "nicotinate-nucleotide pyrophosphorylase [carboxylating]", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030523" }, "gene_names": [ { "name": "QPRT", "type": "recommended", "evidence": [ { "id": "Q3T063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T063" } ] }, { "name": "QPRT", "type": "synonym", "evidence": [ { "id": "NP_001030523", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030523" } ] } ], "protein_names": [ { "name": "Nicotinate-nucleotide pyrophosphorylase [carboxylating]", "type": "recommended", "evidence": [ { "id": "Q3T063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T063/entry#names_and_taxonomy" } ] }, { "name": "2.4.2.19", "type": "synonym", "evidence": [ { "id": "Q3T063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T063/entry#names_and_taxonomy" } ] }, { "name": "QAPRTase", "type": "synonym", "evidence": [ { "id": "NP_001030523", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030523" }, { "id": "Q3T063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T063/entry#names_and_taxonomy" } ] }, { "name": "QPRTase", "type": "synonym", "evidence": [ { "id": "NP_001030523", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030523" }, { "id": "Q3T063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T063/entry#names_and_taxonomy" } ] }, { "name": "Quinolinate phosphoribosyltransferase [decarboxylating]", "type": "synonym", "evidence": [ { "id": "Q3T063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T063/entry#names_and_taxonomy" } ] }, { "name": "nicotinate-nucleotide pyrophosphorylase [carboxylating]", "type": "synonym", "evidence": [ { "id": "NP_001030523", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030523" } ] }, { "name": "nicotinate-nucleotide pyrophosphorylase", "type": "synonym", "evidence": [ { "id": "NP_001030523", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030523" } ] }, { "name": "quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating))", "type": "synonym", "evidence": [ { "id": "NP_001030523", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030523" } ] } ], "function": [ { "annotation": "Involved in the catabolism of quinolinic acid (QA).", "evidence": [ { "database": "UniProtKB", "id": "Q3T063", "url": "https://www.uniprot.org/uniprotkb/Q3T063#function" }, { "database": "UniProtKB", "id": "Q15274", "url": "https://www.uniprot.org/uniprotkb/Q15274#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T063", "url": "https://www.uniprot.org/uniprotkb/Q3T063" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "QPRT", "url": "https://www.uniprot.org/uniprotkb/Q3T063", "locus": { "chromosome": "25", "start_pos": 26491480, "end_pos": 26494332, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018082", "url": "https://www.ensembl.org/id/ENSBTAG00000018082" } ] } } ], "crossref": [ { "id": "Q3T063", "url": "https://alphafold.ebi.ac.uk/entry/Q3T063", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01572", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01572", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614254", "url": "https://www.ncbi.nlm.nih.gov/gene/614254", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004393", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004393", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027277", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027277", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036068", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036068", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614254", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614254", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T063", "url": "https://www.orthodb.org/?gene=Q3T063", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32179", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32179", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32179:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32179:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01729", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01729", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02749", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02749", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030523", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "12733", "url": "https://www.rhea-db.org/rhea/12733", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T063", "url": "https://www.uniprot.org/uniprotkb/Q3T063", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T063-1", "url": "https://www.uniprot.org/uniprotkb/Q3T063-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPEGLAHLLPPATLAALADSWLREDCPGLNYVALVSGTAPSQAVLWAKSPGVLAGRPFLDAIFAQVNCQVSWFLPEGSKLVPVAKVAEVRGPAHCLLLGERVALNTLARCSGVASMAAAAVETARGTGWAGHVAGTRKTTPGFRLVEKYGLLVGGAAAHRYDLGGLVMVKDNHVMAAGGVKKAVRAARRAADFALKVEVECSSLQEAVEAAEAGADLVLLDNFRPEELHPTAATLKAQFPSVSVEASGGVRLDNLPQFCGPHIDVISLGMLTQAAPALDFSLKLFAEGATPVPHARRS", "length": 299, "header": "sp|Q3T063-1|NADC_BOVIN Isoform 1 of Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Bos taurus OX=9913 GN=QPRT PE=2 SV=1 CANONICAL=Q3T063-1" }, "isoforms": [ { "isoform_ac": "Q3T063-1", "url": "https://www.uniprot.org/uniprotkb/Q3T063/entry#Q3T063-1", "sequence": { "sequence": "MDPEGLAHLLPPATLAALADSWLREDCPGLNYVALVSGTAPSQAVLWAKSPGVLAGRPFLDAIFAQVNCQVSWFLPEGSKLVPVAKVAEVRGPAHCLLLGERVALNTLARCSGVASMAAAAVETARGTGWAGHVAGTRKTTPGFRLVEKYGLLVGGAAAHRYDLGGLVMVKDNHVMAAGGVKKAVRAARRAADFALKVEVECSSLQEAVEAAEAGADLVLLDNFRPEELHPTAATLKAQFPSVSVEASGGVRLDNLPQFCGPHIDVISLGMLTQAAPALDFSLKLFAEGATPVPHARRS", "length": 299, "header": "sp|Q3T063-1|NADC_BOVIN Isoform 1 of Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Bos taurus OX=9913 GN=QPRT PE=2 SV=1 CANONICAL=Q3T063-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 291, "end_pos": 291, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3T063", "url": "https://www.uniprot.org/uniprotkb/Q3T063" } ], "site_lbl": "Thr291" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:614254", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614254", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3T063", "url": "https://www.uniprot.org/uniprotkb/Q3T063" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "NAD+ biosynthetic process", "id": "GO:0009435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009435", "evidence": [ { "database": "UniProtKB", "id": "Q3T063", "url": "https://www.uniprot.org/uniprotkb/Q3T063" } ], "pmid": "" }, { "name": "quinolinate catabolic process", "id": "GO:0034213", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034213", "evidence": [ { "database": "UniProtKB", "id": "Q3T063", "url": "https://www.uniprot.org/uniprotkb/Q3T063" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "nicotinate-nucleotide diphosphorylase (carboxylating) activity", "id": "GO:0004514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004514", "evidence": [ { "database": "UniProtKB", "id": "Q3T063", "url": "https://www.uniprot.org/uniprotkb/Q3T063" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12733", "name": "", "equation": "nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3T063-1", "A0A3Q1M3Z8-1" ], "evidence": [ { "id": "12733", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12733" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M3Z8", "gene_name": "QPRT", "activity": [ { "ec_number": "2.4.2.19", "activity": "nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1M3Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3Z8" } ] }, { "ec_number": "2.4.2.19", "activity": "", "evidence": [ { "id": "A0A3Q1M3Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3Z8" } ] } ] }, { "uniprot_ac": "Q3T063", "gene_name": "QPRT", "activity": [ { "ec_number": "2.4.2.19", "activity": "nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+).", "evidence": [ { "id": "Q3T063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T063" } ] }, { "ec_number": "2.4.2.19", "activity": "", "evidence": [ { "id": "Q3T063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T063" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T063-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 299, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T063-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T063" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.4.2.19", "ec_name": "nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+).", "evidence": [ { "id": "2.4.2.19", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.19" }, { "id": "2.4.2.19", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.2.19" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 291 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T064-1", "uniprot_ac": "Q3T064", "uniprot_id": "ROP1_BOVIN", "mass": { "chemical_mass": 23969.0, "monoisotopic_mass": 23969.0 }, "refseq": { "ac": "NP_001069368", "name": "ropporin-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069368" }, "gene_names": [ { "name": "ROPN1", "type": "recommended", "evidence": [ { "id": "Q3T064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T064" } ] }, { "name": "ROPN1", "type": "synonym", "evidence": [ { "id": "NP_001069368", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069368" } ] } ], "protein_names": [ { "name": "Ropporin-1", "type": "recommended", "evidence": [ { "id": "Q3T064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T064/entry#names_and_taxonomy" } ] }, { "name": "Rhophilin-associated protein 1", "type": "synonym", "evidence": [ { "id": "Q3T064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T064/entry#names_and_taxonomy" } ] }, { "name": "rhophilin-associated protein 1", "type": "synonym", "evidence": [ { "id": "NP_001069368", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069368" } ] }, { "name": "ropporin, rhophilin associated protein 1", "type": "synonym", "evidence": [ { "id": "NP_001069368", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069368" } ] }, { "name": "ropporin-1", "type": "synonym", "evidence": [ { "id": "NP_001069368", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069368" } ] } ], "function": [ { "annotation": "Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.", "evidence": [ { "database": "UniProtKB", "id": "Q3T064", "url": "https://www.uniprot.org/uniprotkb/Q3T064#function" }, { "database": "UniProtKB", "id": "Q9ESG2", "url": "https://www.uniprot.org/uniprotkb/Q9ESG2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T064", "url": "https://www.uniprot.org/uniprotkb/Q3T064" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ROPN1", "url": "https://www.uniprot.org/uniprotkb/Q3T064", "locus": { "chromosome": "1", "start_pos": 68349821, "end_pos": 68384919, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006947", "url": "https://www.ensembl.org/id/ENSBTAG00000006947" } ] } } ], "crossref": [ { "id": "Q3T064", "url": "https://alphafold.ebi.ac.uk/entry/Q3T064", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd23019", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23019", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "527583", "url": "https://www.ncbi.nlm.nih.gov/gene/527583", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q3T064", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q3T064*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR047844", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047844", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527583", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527583", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T064", "url": "https://www.orthodb.org/?gene=Q3T064", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14952", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14952", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14952:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14952:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001069368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069368", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T064", "url": "https://www.uniprot.org/uniprotkb/Q3T064", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T064-1", "url": "https://www.uniprot.org/uniprotkb/Q3T064-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPQTDKQICIPPELPELLKQFTKAAIRSQPQDLIQWAAEYFGAMSRGEIPPVRERSERVALSNWAELTPELLKILHSRVGGRLIVQADELAQMWKVLNLPTDLFNSVMNVGRFTEEIEWLKFLALACSSLGVTIAKTLKIVCEVLSSDHDSGPPRIPFSTFQFLYTYIAEVDGEISASHVSRMLNYIEQEVIGPDGLIKVNDFTQNPRVRLE", "length": 212, "header": "sp|Q3T064-1|ROP1_BOVIN Isoform 1 of Ropporin-1 OS=Bos taurus OX=9913 GN=ROPN1 PE=2 SV=1 CANONICAL=Q3T064-1" }, "isoforms": [ { "isoform_ac": "Q3T064-1", "url": "https://www.uniprot.org/uniprotkb/Q3T064/entry#Q3T064-1", "sequence": { "sequence": "MPQTDKQICIPPELPELLKQFTKAAIRSQPQDLIQWAAEYFGAMSRGEIPPVRERSERVALSNWAELTPELLKILHSRVGGRLIVQADELAQMWKVLNLPTDLFNSVMNVGRFTEEIEWLKFLALACSSLGVTIAKTLKIVCEVLSSDHDSGPPRIPFSTFQFLYTYIAEVDGEISASHVSRMLNYIEQEVIGPDGLIKVNDFTQNPRVRLE", "length": 212, "header": "sp|Q3T064-1|ROP1_BOVIN Isoform 1 of Ropporin-1 OS=Bos taurus OX=9913 GN=ROPN1 PE=2 SV=1 CANONICAL=Q3T064-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 56, "end_pos": 56, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", 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Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. 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factor 3 homolog, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q3T0E3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E3/entry#names_and_taxonomy" } ] }, { "name": "Coiled-coil domain-containing protein 56", "type": "synonym", "evidence": [ { "id": "Q3T0E3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E3/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain containing 56", "type": "synonym", "evidence": [ { "id": "NP_001029855", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029855" } ] }, { "name": "coiled-coil domain-containing protein 56", "type": "synonym", "evidence": [ { "id": "NP_001029855", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029855" } ] }, { "name": "cytochrome c oxidase assembly factor 3 homolog, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001029855", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029855" } ] }, { "name": "cytochrome c oxidase assembly protein 3 homolog, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001029855", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029855" } ] } ], "function": [ { "annotation": "Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E3", "url": "https://www.uniprot.org/uniprotkb/Q3T0E3#function" }, { "database": "UniProtKB", "id": "Q9Y2R0", "url": "https://www.uniprot.org/uniprotkb/Q9Y2R0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0E3", "url": "https://www.uniprot.org/uniprotkb/Q3T0E3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COA3", "url": "https://www.uniprot.org/uniprotkb/Q3T0E3", "locus": { "chromosome": "19", "start_pos": 42827055, "end_pos": 42828164, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019911", "url": "https://www.ensembl.org/id/ENSBTAG00000019911" } ] } } ], "crossref": [ { "id": "Q3T0E3", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0E3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019911", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019911", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539832", "url": "https://www.ncbi.nlm.nih.gov/gene/539832", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018628", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018628", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539832", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539832", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MHFIRQV", "url": "https://omabrowser.org/oma/group/MHFIRQV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0E3", "url": "https://www.orthodb.org/?gene=Q3T0E3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15642", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15642", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15642:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15642:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09813", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09813", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9864848", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029855", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0E3", "url": "https://www.uniprot.org/uniprotkb/Q3T0E3", 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"https://www.uniprot.org/uniprotkb/Q3T0E9/entry#names_and_taxonomy" } ] }, { "name": "N-arachidonyl glycine receptor", "type": "synonym", "evidence": [ { "id": "NP_001029861", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029861" } ] }, { "name": "NAGly receptor", "type": "synonym", "evidence": [ { "id": "NP_001029861", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029861" }, { "id": "Q3T0E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "G protein-coupled receptor (GPCR) that plays a role in diverse physiological processes particularly within the immune and nervous systems. Becomes active when triggered by various endogenous ligands including endocannabinoid N-arachidonyl glycine (NAGly), delta-9-tetrahydrocannabinol or resolvin D2/RvD2 derived from the omega-3 fatty acid docosahexaenoic acid (DHA). Upon RvD2 binding, facilitates the resolution of inflammation, aiding in tissue repair and homeostasis. Mechanistically, RvD2 ligation initiates Galphas protein coupling, activation of cAMP-PKA signaling pathway and phosphorylation of STAT3, leading to RvD2-stimulated macrophage phagocytosis. Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (By similarity). Activation by N-arachidonoyl glycine (NAGly) can also induce apoptosis in macrophages (By similarity). Plays a role in homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intestine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Participates also in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E9", "url": "https://www.uniprot.org/uniprotkb/Q3T0E9#function" }, { "database": "UniProtKB", "id": "Q14330", "url": "https://www.uniprot.org/uniprotkb/Q14330#function" }, { "database": "UniProtKB", "id": "Q8K1Z6", "url": "https://www.uniprot.org/uniprotkb/Q8K1Z6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0E9", "url": "https://www.uniprot.org/uniprotkb/Q3T0E9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPR18", "url": "https://www.uniprot.org/uniprotkb/Q3T0E9", "locus": { "chromosome": "12", "start_pos": 76118022, "end_pos": 76122110, "strand": "+", "evidence": [ { 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"database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029861", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0E9", "url": "https://www.uniprot.org/uniprotkb/Q3T0E9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0E9-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0E9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTPHSQAQPGLPIDPHPDEYKVAALVFYSCIFIIGLFVNVTALWVFSCTTKKRTTVTVYMMNVALLDLVFIMSLPFRMLYYAKGEWPFGEYFCRILGALTVFYPSIALWLLAFISADRYMAIVQPKYAKELKNTCKAVMACVGVWIMTLTTTIPLLLLYEDPDTASSTPPTCLKISDIIYLKAINALNFTRLIFFFLIPLFIMIGCYLVIIHSLLHGKTSKLKPKVKEKSIRIIITLMVQVLVCFMPFHICFAFLMLGGDENSYNPWGAFTTFLMNLSTCLDVILYYIVSKQFQARVISVMLYRNYLRSVRRKSFRSGSLRSLSNINSEML", "length": 332, "header": "sp|Q3T0E9-1|GPR18_BOVIN Isoform 1 of N-arachidonyl glycine receptor OS=Bos taurus OX=9913 GN=GPR18 PE=2 SV=1 CANONICAL=Q3T0E9-1" }, "isoforms": [ { 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"https://www.genome.jp/dbget-bin/www_bget?bta:540038", "resource": "KEGG Pathway" }, { "id": "R-BTA-373076", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373076", "resource": "Reactome", "description": "Class A/1 (Rhodopsin-like receptors)" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZWE5-1", "protein_name": "N-arachidonyl glycine receptor", "gene_name": "GPR18", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTTPHNQTHPGPSDNSHPDEYKIAALVFYSCIFIIGLFVNVTALWVFSCTTKKRTTVTIYMMNVALLDLIFILTLPFRMFYYAKGEWPFGANFCQILAALTVFYPSIALWLLAFISADRYMAIVQPKYAKELKNTCKAVLACVGVWIMTLTTTTPLLLLYDDPDRASTPATCLKISDIIHLKAINVLNFTRLIFFFLIPLFIMIGCYLVIIHSLLHGKTSKLKPKVKEKSIRIIITLMVQVLVCFMPFHVCFAFLMLGGDENSYNPWGAFTTFLMNLSTCLDVILYYIVSKQFQARVISVMLYRNYLRSVRRKSFRSGSLRSLSNINSEML", "length": 331 }, "evidence": [ { "id": "Q3T0E9", "url": "https://omabrowser.org/oma/group/Q3T0E9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A1A5S3-1", "protein_name": "N-arachidonyl glycine receptor", "gene_name": "Gpr18", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAIPSNRDQLALSNGSHPEEYKIAALVFYSCIFLIGLLVNVTALWVFSCTTKKRTTVTIYMMNVALLDLVFILSLPFRMFYYAKGEWPFGDYFCHILGALVVFYPSLALWLLALISADRYMAIVQPKYAKELKNTGKAVLACVGVWIMTLTTTVPLLLLDEDPDKASSPATCLKISDIIHLKAVNVLNFTRLIFFFLIPLFIMIGCYVVIIHSLLRGQTSKLKPKVKEKSIRIIVTLLLQVLACFVPFHICFALLMLQGEENSYSPWGAFTTFLMNLSTCLDVVLYYIVSKQFQARVISVMLYRNYLRSVRRKSVRSGSLRSLSNMNSEML", "length": 331 }, "evidence": [ { "id": "Q3T0E9", "url": "https://omabrowser.org/oma/group/Q3T0E9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NA96-1", "protein_name": "N-arachidonyl glycine receptor", "gene_name": "GPR18", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MMPENHYPEEYRISSLVFYSFVFIVGLVVNATALWVFSCSTKKRTTITIYMMNVALLDITFILSLPFRIIYHGKEMWPFGDIFCRIIGAFTVFYPAIALWLLAFISVDRFMAIVQPKHVKELKNTKKALLACTGIWIMTLATTSPLLFLRSDPDKAFNFTTCMKMLDIIHLKEVNMLNFSRLIFFFLIPLLIMMGCYLVIIYNFIHGRTSKLKPKAKERSIRIIVTLIAQVLVCFVPFHICFALMMLNEGTSYNPWAAFTTFLMNLSTCLDVILYYIVSKQFQARVISVILYRNYLRSVRRKSFRTASVRSLNNINSEMI", "length": 320 }, "evidence": [ { "id": "Q3T0E9", "url": "https://omabrowser.org/oma/group/Q3T0E9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HGR4-1", "protein_name": "N-arachidonyl glycine receptor", "gene_name": "Gpr18", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTTPSDLDRLVLSSHSHPDEYKIAALVFYSCIFLIGLLVNVTALWVFSCTTKKRTTVTIYMMNVALLDLIFILSLPFRMFYYAKGEWPFGEYFCHVLGILVVFYPGLALWLLAFISADRYMAIVQPKYAKELKNTCKAVLACVGVWIMTLTTTVPLILLYEDPDKATSPATCLKVSDIIHLKAVNVLNFTRLAFFFLLPLLVMIGCYVVITHSLLRGQTSQLKPAVKEKSIRIIFTLLVQVLLCFVPFHICFAFLMLHGEGNSYNPWGAFTTFLMNLSTCLDVVLYYIVSKQFQARVISVMLYRNYLRSVRRKSFRSGSLRSLSNMNSEMV", "length": 331 }, "evidence": [ { "id": "Q3T0E9", "url": "https://omabrowser.org/oma/group/Q3T0E9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q14330-1", "protein_name": "N-arachidonyl glycine receptor", "gene_name": "GPR18", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MITLNNQDQPVPFNSSHPDEYKIAALVFYSCIFIIGLFVNITALWVFSCTTKKRTTVTIYMMNVALVDLIFIMTLPFRMFYYAKDEWPFGEYFCQILGALTVFYPSIALWLLAFISADRYMAIVQPKYAKELKNTCKAVLACVGVWIMTLTTTTPLLLLYKDPDKDSTPATCLKISDIIYLKAVNVLNLTRLTFFFLIPLFIMIGCYLVIIHNLLHGRTSKLKPKVKEKSIRIIITLLVQVLVCFMPFHICFAFLMLGTGENSYNPWGAFTTFLMNLSTCLDVILYYIVSKQFQARVISVMLYRNYLRSMRRKSFRSGSLRSLSNINSEML", "length": 331 }, "evidence": [ { "id": "Q3T0E9", "url": "https://omabrowser.org/oma/group/Q3T0E9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8K1Z6-1", "protein_name": "N-arachidonyl glycine receptor", "gene_name": "Gpr18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATLSNHNQLDLSNGSHPEEYKIAALVFYSCIFLIGLFVNVTALWVFSCTTKKRTTVTIYMMNVALLDLVFILSLPFRMFYYAKGEWPFGEYFCHILGALVVFYPSLALWLLAFISADRYMAIVQPKYAKELKNTGKAVLACGGVWVMTLTTTVPLLLLYEDPDKASSPATCLKISDITHLKAVNVLNFTRLIFFFLIPLFIMIGCYVVIIHSLLRGQTSKLKPKVKEKSIRIIMTLLLQVLVCFVPFHICFAVLMLQGQENSYSPWGAFTTFLMNLSTCLDVVLYYIVSKQFQARVISVMLYRNYLRSVRRKSVRSGSLRSLSNMNSEML", "length": 331 }, "evidence": [ { "id": "Q3T0E9", "url": "https://omabrowser.org/oma/group/Q3T0E9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E9", "url": "https://www.uniprot.org/uniprotkb/Q3T0E9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E9", "url": "https://www.uniprot.org/uniprotkb/Q3T0E9" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E9", "url": "https://www.uniprot.org/uniprotkb/Q3T0E9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "Q3T0E9", "url": "https://www.uniprot.org/uniprotkb/Q3T0E9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 189, "end_pos": 191, "annotation": "n_glycosylation_sequon" }, { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0E9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 332, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0E9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0E9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 189 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 323 ], "sequon_annotation_sites": [ { "start_pos": 189, "end_pos": 191 }, { "start_pos": 277, "end_pos": 279 }, { "start_pos": 40, "end_pos": 42 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0K1-1", "uniprot_ac": "Q3T0K1", "uniprot_id": "CALU_BOVIN", "mass": { "chemical_mass": 37083.0, "monoisotopic_mass": 37083.0 }, "refseq": { "ac": "NP_001029837", "name": "calumenin precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029837" }, "gene_names": [ { "name": "CALU", "type": "recommended", "evidence": [ { "id": "Q3T0K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K1" } ] }, { "name": "CALU", "type": "synonym", "evidence": [ { "id": "NP_001029837", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029837" } ] } ], "protein_names": [ { "name": "Calumenin", "type": "recommended", "evidence": [ { "id": "Q3T0K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K1/entry#names_and_taxonomy" } ] }, { "name": "calumenin precursor", "type": "synonym", "evidence": [ { "id": "NP_001029837", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029837" } ] } ], "function": [ { "annotation": "Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T0K1", "url": "https://www.uniprot.org/uniprotkb/Q3T0K1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0K1", "url": "https://www.uniprot.org/uniprotkb/Q3T0K1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CALU", "url": "https://www.uniprot.org/uniprotkb/Q3T0K1", "locus": { "chromosome": "4", "start_pos": 92743560, "end_pos": 92719806, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016481", "url": "https://www.ensembl.org/id/ENSBTAG00000016481" } ] } } ], "crossref": [ { "id": "Q3T0K1", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0K1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd16228", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16228", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539218", "url": "https://www.ncbi.nlm.nih.gov/gene/539218", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539218", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539218", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T0K1", "url": "https://www.orthodb.org/?gene=Q3T0K1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10827", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10827", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10827:SF88", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10827:SF88", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13202", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13202", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13833", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13833", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029837", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0K1", "url": "https://www.uniprot.org/uniprotkb/Q3T0K1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0K1-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0K1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAKTFDQLTPEESKERLGMIVDKIDADKDGFVTEGELKSWIKHAQKKYIYDNVENQWQEFDLNQDGLISWDEYRNVTYGTYLDDPDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQEPMEDIDKNADGFIDLEEYIGDMYSHDGNADEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKDGKLTKEEIVDKYDLFVGSQATDFGEALVRHDEF", "length": 315, "header": "sp|Q3T0K1-1|CALU_BOVIN Isoform 1 of Calumenin OS=Bos taurus OX=9913 GN=CALU PE=2 SV=1 CANONICAL=Q3T0K1-1" }, "isoforms": [ { "isoform_ac": "Q3T0K1-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0K1/entry#Q3T0K1-1", "sequence": { "sequence": "MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAKTFDQLTPEESKERLGMIVDKIDADKDGFVTEGELKSWIKHAQKKYIYDNVENQWQEFDLNQDGLISWDEYRNVTYGTYLDDPDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQEPMEDIDKNADGFIDLEEYIGDMYSHDGNADEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKDGKLTKEEIVDKYDLFVGSQATDFGEALVRHDEF", "length": 315, "header": "sp|Q3T0K1-1|CALU_BOVIN Isoform 1 of Calumenin OS=Bos taurus OX=9913 GN=CALU PE=2 SV=1 CANONICAL=Q3T0K1-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 131, "start_aa": "Asn", "end_pos": 131, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn131", "evidence": [ { "id": "Q3T0K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0K1#ptm_processing" } ] } ], 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"https://www.ebi.ac.uk/interpro/entry/pfam/PF21283", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030367", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0L5", "url": "https://www.uniprot.org/uniprotkb/Q3T0L5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0L5-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0L5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPPQVLAFGLLVAAATAAVAADQEGCVCENYKLTTNCSVNALGQCQCTSVGTQHSVICTKLATKCLVMKAEMNHSKSGRRGKPEGAIQNNDGLYDPECDDKGLFKAKQCNGTSTCWCVNTAGVRRTDKDSEISCSEPVRTYWIIIELKHKTREKPYDLQSLQSALKDVITNRYQLDPKYITNILYENDVITIDLVQNSSQKTQNDVDIADVAYYFEKDVKDESLFHSKRMDLRVNGELLDLDPGRTSIYYVDEKPPEFSMQGLQAGIIAVIVVVVVAIIAGIIVLVVSRKKSMTKYEKAEIKEMGEMHRELNA", "length": 314, "header": "sp|Q3T0L5-1|EPCAM_BOVIN Isoform 1 of Epithelial cell adhesion molecule OS=Bos taurus OX=9913 GN=EPCAM PE=2 SV=1 CANONICAL=Q3T0L5-1" }, "isoforms": [ { "isoform_ac": "Q3T0L5-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0L5/entry#Q3T0L5-1", "sequence": { "sequence": "MAPPQVLAFGLLVAAATAAVAADQEGCVCENYKLTTNCSVNALGQCQCTSVGTQHSVICTKLATKCLVMKAEMNHSKSGRRGKPEGAIQNNDGLYDPECDDKGLFKAKQCNGTSTCWCVNTAGVRRTDKDSEISCSEPVRTYWIIIELKHKTREKPYDLQSLQSALKDVITNRYQLDPKYITNILYENDVITIDLVQNSSQKTQNDVDIADVAYYFEKDVKDESLFHSKRMDLRVNGELLDLDPGRTSIYYVDEKPPEFSMQGLQAGIIAVIVVVVVAIIAGIIVLVVSRKKSMTKYEKAEIKEMGEMHRELNA", "length": 314, "header": "sp|Q3T0L5-1|EPCAM_BOVIN Isoform 1 of Epithelial cell adhesion molecule OS=Bos taurus OX=9913 GN=EPCAM PE=2 SV=1 CANONICAL=Q3T0L5-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 111, "start_aa": "Asn", "end_pos": 111, 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"end_pos": 37, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn37", "evidence": [ { "id": "Q3T0L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0L5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 74, "start_aa": "Asn", "end_pos": 74, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn74", "evidence": [ { "id": "Q3T0L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0L5#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton 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"id": "Q3T0M9", "url": "https://www.uniprot.org/uniprotkb/Q3T0M9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M9", "url": "https://www.uniprot.org/uniprotkb/Q3T0M9" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M9", "url": "https://www.uniprot.org/uniprotkb/Q3T0M9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M9", "url": "https://www.uniprot.org/uniprotkb/Q3T0M9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3T0M9", "url": 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"https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0M9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0M9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": 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} ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0Q6-1", "uniprot_ac": "Q3T0Q6", "uniprot_id": "CNBP_BOVIN", "mass": { "chemical_mass": 18742.0, "monoisotopic_mass": 18742.0 }, "refseq": { "ac": "NP_001029396", "name": "CCHC-type zinc finger nucleic acid binding protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029396" }, "gene_names": [ { "name": "CNBP", "type": "recommended", "evidence": [ { "id": "Q3T0Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6" } ] }, { "name": "CNBP", "type": "synonym", "evidence": [ { "id": "NP_001029396", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029396" } ] }, { "name": "ZNF9", "type": "synonym", "evidence": [ { "id": "Q3T0Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6" } ] } ], "protein_names": [ { "name": "CCHC-type zinc finger nucleic acid binding protein", "type": "recommended", "evidence": [ { "id": "Q3T0Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6/entry#names_and_taxonomy" } ] }, { "name": "CCHC-type zinc finger nucleic acid binding protein", "type": "synonym", "evidence": [ { "id": "NP_001029396", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029396" } ] }, { "name": "CNBP", "type": "synonym", "evidence": [ { "id": "Q3T0Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6/entry#names_and_taxonomy" } ] }, { "name": "Cellular nucleic acid-binding protein", "type": "synonym", "evidence": [ { "id": "Q3T0Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein 9", "type": "synonym", "evidence": [ { "id": "Q3T0Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6/entry#names_and_taxonomy" } ] }, { "name": "cellular nucleic acid-binding protein", "type": "synonym", "evidence": [ { "id": "NP_001029396", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029396" } ] }, { "name": "zinc finger protein 9", "type": "synonym", "evidence": [ { "id": "NP_001029396", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029396" } ] } ], "function": [ { "annotation": "Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (By similarity). Has a role as transactivator of the Myc promoter (By similarity). Binds single-stranded RNA in a sequence-specific manner (By similarity). Binds G-rich elements in target mRNA coding sequences (By similarity). Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q6", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6#function" }, { "database": "UniProtKB", "id": "P62633", "url": "https://www.uniprot.org/uniprotkb/P62633#function" }, { "database": "UniProtKB", "id": "P53996", "url": "https://www.uniprot.org/uniprotkb/P53996#function" }, { "database": "UniProtKB", "id": "P62634", "url": "https://www.uniprot.org/uniprotkb/P62634#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q6", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CNBP", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6", "locus": { "chromosome": "22", "start_pos": 59070589, "end_pos": 59080268, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012159", "url": "https://www.ensembl.org/id/ENSBTAG00000012159" } ] } } ], "crossref": [ { "id": "Q3T0Q6", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0Q6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012159", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012159", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504831", "url": "https://www.ncbi.nlm.nih.gov/gene/504831", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504831", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504831", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KGNPTCY", "url": "https://omabrowser.org/oma/group/KGNPTCY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0Q6", "url": "https://www.orthodb.org/?gene=Q3T0Q6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47103:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47103:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00098", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00098", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029396", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029396", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0Q6", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0Q6-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSNECFKCGRSGHWARECPTGGGRGRGMRSRGRGFQFVSSSLPDICYRCGESGHLAKDCDLQEDACYNCGRGGHIAKDCKEPKREREQCCYNCGKPGHLARDCDHADEQKCYSCGEFGHIQKDCTKVKCYRCGETGHVAINCSKTSEVNCYRCGESGHLARECTIEATA", "length": 170, "header": "sp|Q3T0Q6-1|CNBP_BOVIN Isoform 1 of CCHC-type zinc finger nucleic acid binding protein OS=Bos taurus OX=9913 GN=CNBP PE=2 SV=1 CANONICAL=Q3T0Q6-1" }, "isoforms": [ { "isoform_ac": "Q3T0Q6-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6/entry#Q3T0Q6-1", "sequence": { "sequence": "MSSNECFKCGRSGHWARECPTGGGRGRGMRSRGRGFQFVSSSLPDICYRCGESGHLAKDCDLQEDACYNCGRGGHIAKDCKEPKREREQCCYNCGKPGHLARDCDHADEQKCYSCGEFGHIQKDCTKVKCYRCGETGHVAINCSKTSEVNCYRCGESGHLARECTIEATA", "length": 170, "header": "sp|Q3T0Q6-1|CNBP_BOVIN Isoform 1 of CCHC-type zinc finger nucleic acid binding protein OS=Bos taurus OX=9913 GN=CNBP PE=2 SV=1 CANONICAL=Q3T0Q6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 42, "end_pos": 42, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q6", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6" } ], "site_lbl": "Ser42" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504831", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504831", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7GF54-1", "protein_name": "CCHC-type zinc finger nucleic acid binding protein", "gene_name": "Cnbp", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSSNECFKCGRSGHWARECPTGGGRGRGMRSRGRGGFTSDRGFQFVSSSLPDICYRCGESGHLAKDCDLQEDEACYNCGRGGHIAKDCKEPKREREQCCYNCGKPGHLARDCDHADEQKCYSCGEFGHIQKDCTKVKCYRCGETGHVAINCSKTSEVNCYRCGESGHLARECTIEATA", "length": 178 }, "evidence": [ { "id": "Q3T0Q6", "url": "https://omabrowser.org/oma/group/Q3T0Q6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1Q6Z5-1", "protein_name": "CCHC-type zinc finger, nucleic acid binding protein a", "gene_name": "cnbpa", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDMSTSECFGCGRSGHWIKNCPNAGRGRGRGRGRGKDLFCYRCGEQGHIARDCEQTEDACYNCHRSGHISRDCKEPKKEREQCCYNCGKAGHVARDCDHANEQKCYSCGGFGHIQKLCDKVKCYRCGEIGHVAVQCSKATEVNCYNCGKTGHLARDCSIEASA", "length": 163 }, "evidence": [ { "id": "Q3T0Q6", "url": "https://omabrowser.org/oma/group/Q3T0Q6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P53996-1", "protein_name": "CCHC-type zinc finger nucleic acid binding protein", "gene_name": "Cnbp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSNECFKCGRSGHWARECPTGGGRGRGMRSRGRGGFTSDRGFQFVSSSLPDICYRCGESGHLAKDCDLQEDEACYNCGRGGHIAKDCKEPKREREQCCYNCGKPGHLARDCDHADEQKCYSCGEFGHIQKDCTKVKCYRCGETGHVAINCSKTSEVNCYRCGESGHLARECTIEATA", "length": 178 }, "evidence": [ { "id": "Q3T0Q6", "url": "https://omabrowser.org/oma/group/Q3T0Q6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P62633-1", "protein_name": "CCHC-type zinc finger nucleic acid binding protein", "gene_name": "CNBP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSNECFKCGRSGHWARECPTGGGRGRGMRSRGRGGFTSDRGFQFVSSSLPDICYRCGESGHLAKDCDLQEDACYNCGRGGHIAKDCKEPKREREQCCYNCGKPGHLARDCDHADEQKCYSCGEFGHIQKDCTKVKCYRCGETGHVAINCSKTSEVNCYRCGESGHLARECTIEATA", "length": 177 }, "evidence": [ { "id": "Q3T0Q6", "url": "https://omabrowser.org/oma/group/Q3T0Q6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P62634-1", "protein_name": "CCHC-type zinc finger nucleic acid binding protein", "gene_name": "Cnbp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSNECFKCGRSGHWARECPTGGGRGRGMRSRGRGGFTSDRGFQFVSSSLPDICYRCGESGHLAKDCDLQEDACYNCGRGGHIAKDCKEPKREREQCCYNCGKPGHLARDCDHADEQKCYSCGEFGHIQKDCTKVKCYRCGETGHVAINCSKTSEVNCYRCGESGHLARECTIEATA", "length": 177 }, "evidence": [ { "id": "Q3T0Q6", "url": "https://omabrowser.org/oma/group/Q3T0Q6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8T8R1-1", "protein_name": "CCHC-type zinc finger nucleic acid binding protein", "gene_name": "CNBP", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSMSATCYKCNRPGHFARDCSLGGGGGPGGVGGGGGGGGGGMRGNDGGGMRRNREKCYKCNQFGHFARACPEEAERCYRCNGIGHISKDCTQADNPTCYRCNKTGHWVRNCPEAVNERGPTNVSCYKCNRTGHISKNCPETSKTCYGCGKSGHLRRECDEKGGRN", "length": 165 }, "evidence": [ { "id": "Q3T0Q6", "url": "https://omabrowser.org/oma/group/Q3T0Q6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of cytoplasmic translation", "id": "GO:2000767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000767", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q6", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q6", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q6", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q6", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q6", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6" } ], "pmid": "" }, { "name": "single-stranded RNA binding", "id": "GO:0003727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003727", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q6", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6" } ], "pmid": "" }, { "name": "translation regulator activity", "id": "GO:0045182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045182", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q6", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q6", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q6", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q6", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0Q6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 170, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0Q6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0Q6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 42 ], "sequon_annotation_sites": [ { "start_pos": 142, "end_pos": 144 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0Q8-1", "uniprot_ac": "Q3T0Q8", "uniprot_id": "UT14A_BOVIN", "mass": { "chemical_mass": 88087.0, "monoisotopic_mass": 88087.0 }, "refseq": { "ac": "NP_001029413", "name": "U3 small nucleolar RNA-associated protein 14 homolog A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029413" }, "gene_names": [ { "name": "UTP14A", "type": "recommended", "evidence": [ { "id": "Q3T0Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8" } ] }, { "name": "UTP14A", "type": "synonym", "evidence": [ { "id": "NP_001029413", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029413" } ] }, { "name": "UTP14C", "type": "synonym", "evidence": [ { "id": "NP_001029413", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029413" } ] } ], "protein_names": [ { "name": "U3 small nucleolar RNA-associated protein 14 homolog A", "type": "recommended", "evidence": [ { "id": "Q3T0Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8/entry#names_and_taxonomy" } ] }, { "name": "U3 small nucleolar RNA-associated protein 14 homolog A", "type": "synonym", "evidence": [ { "id": "NP_001029413", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029413" } ] }, { "name": "UTP14, U3 small nucleolar ribonucleoprotein, homolog C", "type": "synonym", "evidence": [ { "id": "NP_001029413", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029413" } ] } ], "function": [ { "annotation": "May be required for ribosome biogenesis.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q8", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q8", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UTP14A", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8", "locus": { "chromosome": "X", "start_pos": 13937434, "end_pos": 13920836, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013671", "url": "https://www.ensembl.org/id/ENSBTAG00000013671" } ] } } ], "crossref": [ { "id": "Q3T0Q8", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0Q8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013671", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013671", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505324", "url": "https://www.ncbi.nlm.nih.gov/gene/505324", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006709", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505324", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505324", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QVIEPMD", "url": "https://omabrowser.org/oma/group/QVIEPMD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0Q8", "url": "https://www.orthodb.org/?gene=Q3T0Q8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14150", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14150", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14150:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14150:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04615", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04615", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029413", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0Q8", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0Q8-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNANQAAESNLLASNQQKELEDLPKDYPLSTSEDEGDKDEERKHQKLLESISSLNGKDRQKLADRSEASLKVSEFSVSSEGSGEKLVLSDLLEPVKTSSSLAAVKKQLNRVKSKKTVELPLHREEIERIHREVAFNKSSQILSKWDPVVLKNRQAEQLVFPLSKPQSAFAPIEHVVNGWKAGTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLKAMSLEEVKMRRAELQRARALQSYYEARARREKRIKSKKYHRILKKGKAKQALKDFEKLQKVNPAAALEELEKLDKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLARNKELTQKVRAASESEEEGEGQEEEEEPLVPDLVNEVQIKANGLNPWMFRNHFIDAKEAEVQKDLEDPAEPEAQETSESEEEKAVVEEETLLKEFEERRSLRQKSELNHMAEPVHRRVTKDPSSQEVLSDLRALCQKLRTENHQSGKQELSSARTAQREEPAREEEEPMLLQRPERARTLDELEELGREGCVENEELPRTAVEGLQLEKNLSNHIGAPKEKKRKEQMIDLQNLLTTKSPSVKSLAVPTTVQELEDEEERDQRQIIKEAFAGDDVIRDFLKEKREAVEASKPKDLDLTLPGWGEWGGIGLKPSAKKRRRFLIKAPEGPPRKDKNLPNVIINEKRNTHAAAHQVQVLPHPFTHHQQFERTIQTPVGSTWNTQRAFQKLTMPKVVTKPGHIIKPIKAEDVGYRSSSRSDLSVVQRNPKRLSIRHKKHLENNCVD", "length": 770, "header": "sp|Q3T0Q8-1|UT14A_BOVIN Isoform 1 of U3 small nucleolar RNA-associated protein 14 homolog A OS=Bos taurus OX=9913 GN=UTP14A PE=2 SV=1 CANONICAL=Q3T0Q8-1" }, "isoforms": [ { "isoform_ac": "Q3T0Q8-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8/entry#Q3T0Q8-1", "sequence": { "sequence": "MNANQAAESNLLASNQQKELEDLPKDYPLSTSEDEGDKDEERKHQKLLESISSLNGKDRQKLADRSEASLKVSEFSVSSEGSGEKLVLSDLLEPVKTSSSLAAVKKQLNRVKSKKTVELPLHREEIERIHREVAFNKSSQILSKWDPVVLKNRQAEQLVFPLSKPQSAFAPIEHVVNGWKAGTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLKAMSLEEVKMRRAELQRARALQSYYEARARREKRIKSKKYHRILKKGKAKQALKDFEKLQKVNPAAALEELEKLDKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLARNKELTQKVRAASESEEEGEGQEEEEEPLVPDLVNEVQIKANGLNPWMFRNHFIDAKEAEVQKDLEDPAEPEAQETSESEEEKAVVEEETLLKEFEERRSLRQKSELNHMAEPVHRRVTKDPSSQEVLSDLRALCQKLRTENHQSGKQELSSARTAQREEPAREEEEPMLLQRPERARTLDELEELGREGCVENEELPRTAVEGLQLEKNLSNHIGAPKEKKRKEQMIDLQNLLTTKSPSVKSLAVPTTVQELEDEEERDQRQIIKEAFAGDDVIRDFLKEKREAVEASKPKDLDLTLPGWGEWGGIGLKPSAKKRRRFLIKAPEGPPRKDKNLPNVIINEKRNTHAAAHQVQVLPHPFTHHQQFERTIQTPVGSTWNTQRAFQKLTMPKVVTKPGHIIKPIKAEDVGYRSSSRSDLSVVQRNPKRLSIRHKKHLENNCVD", "length": 770, "header": "sp|Q3T0Q8-1|UT14A_BOVIN Isoform 1 of U3 small nucleolar RNA-associated protein 14 homolog A OS=Bos taurus OX=9913 GN=UTP14A PE=2 SV=1 CANONICAL=Q3T0Q8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 206, "end_pos": 206, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q8", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8" } ], "site_lbl": "Thr206" }, { "start_pos": 30, "end_pos": 30, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q8", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8" } ], "site_lbl": "Ser30" }, { "start_pos": 32, "end_pos": 32, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q8", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8" } ], "site_lbl": "Ser32" }, { "start_pos": 406, "end_pos": 406, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q8", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8" } ], "site_lbl": "Ser406" }, { "start_pos": 408, "end_pos": 408, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q8", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8" } ], "site_lbl": "Ser408" }, { "start_pos": 453, "end_pos": 453, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q8", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8" } ], "site_lbl": "Ser453" }, { "start_pos": 53, "end_pos": 53, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q8", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8" } ], "site_lbl": "Ser53" }, { "start_pos": 567, "end_pos": 567, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q8", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8" } ], "site_lbl": "Ser567" }, { "start_pos": 78, "end_pos": 78, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q8", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8" } ], "site_lbl": "Ser78" }, { "start_pos": 82, "end_pos": 82, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q8", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8" } ], "site_lbl": "Ser82" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q8", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:505324", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505324", "resource": "KEGG Pathway" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AJ81-1", "protein_name": "UTP14A small subunit processome component", "gene_name": "Utp14a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSCVIGGSKNCFAAGKEVALSLASVLDPCELPATKMSAIKATKGLLALSQQDDLMDLPTNYPLSDSEDEAGSDGERKHQKLLEAIGSLSGKNRWKLPERSEAGLKVSEFNVSSEGSGEKLALSDLLEPLKSSSSLAAVKKQLNRVKSKKTLELPLHKGEVERVHREVAFSNTSQALSKWDSVVQKNRAAEQLVFPLEKEPTFVPMEHVFCEWKARSPLEQEIFNLLHKNKQPVTDPLLTPVEKASLKAMSLEEAKIRRAELQRARALQSYYEARARRMKKIKSKKAVEAGESALQKSGGGSESQPCQVPYWLPPSQPALVAILAPVYHKIVKKGKAQKALKDFEQLRKVDPDAALEELEKMEKARMLERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVVSESEEERDAEEEEALVPDIVNEVQKAAHGPNPWMLRSCNHDAKENEIQADPEQLPEPAAPEFSKNEGDEKPVAEEGKLLEELEKRRSLRKRSELNHDAEPARDQKPKDSTNQEVLSELRALSKKLSKENHPFEKQKESPAKTVGLVQEEEPGPEEDEPLLLQRPERVRTLEELEELGKEYSLPNKELSRPSVEGEQMRTNPQNQTKGKNKKEQMISLQNLLTTRTPSVTSLALPTTVEELDDEVKRNQKQMIKEAFAGDDVIKEFLKEKREAVQANKPKDVDLTLPGWGEWGGMDLKPSAKKRRRFLIKAPEGPPRKDKNLPNVIINEKRNIHIAAHQVRVLPYPFTHHQQFERTIQNPIGSTWITQRAFQKLTAPKVVTKPGHIIKPITADDVGRQSSPRSDLSVMQTNPKRHCKHQKQLKKKAL", "length": 841 }, "evidence": [ { "id": "Q3T0Q8", "url": "https://omabrowser.org/oma/group/Q3T0Q8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A2CEY8-1", "protein_name": "Uncharacterized protein LOC553498", "gene_name": "si:dkey-251i10.3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVKRSSLQKTTPSEGVTSAMAADSGDEEELYTDPEQAISASEDEEGSDDERKHNKLLEAISSMGGRKRKKQSERSEASVQVSEFFVNAEGAGDKINLSDLLGVVEKTAGASNKTKKQLRNLQSTKETLELPLNKQQKEKIQRGIAYVKTAEEVSNWQNIIVQNQRAEQMVFPLKQEPSGPKRVEQVVAGWKVKTPLEQEIFQLLHSNSQPVLDPVLTPVEEASLKAMSLEEAKIRRAELQKARALQSYYEAKAKREKKIKSKQYHRVQKKAKRKEFLKQFDEMVKSNPQEALEELKKMEMSRMQERMSLKHQNSGKWAKSKAIMAKYDDSARKAMQEQLQMNKDLTQKIVVLSDDEQADEDLEAVPDFVNDPEPIIDPVNPWMRGQLTQEEPEVSCVTTDELQAAEEEKEDEEEELLGEFERKRKMRQADEAEDLIPTEEKTEHVSEVAGEDVVEISDNDDEEEEDDDDDEEEEKEEEEEEEEEDVSKFNSLFNLMRSEKTQKGQEDGEELLDEGQVRVRNMEDLEDLGEGFEPQPSTTPSVTQTAIADKTSEPQNKKGISLSEVLTKEAKVIKVPFLPTVVEHEETEHDEQLSIIKEAFAGDDVISDFMKDKKKQEEAGRPKVVDLTLPGWGEWGGIGLKPSRRKRKRFTKKMDPPPPRQDRKLPDVIISEKRNTSIAAHQVSHLPFPYENPAQFESTIRTPVGQTWNTQSVVKKMTTPKVVTKMGAIIEPMAKEDLIKGKSSTAAGKAPALTLGQRDKRAKVGEKRSSQKKPGKRAPKKKRKQ", "length": 785 }, "evidence": [ { "id": "Q3T0Q8", "url": "https://omabrowser.org/oma/group/Q3T0Q8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F4JHI1-1", "protein_name": "U3 ribonucleoprotein (Utp) family protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGEKRKSTSKTLAKNKKRKGPHLPNSILKTIANEKRPLNSDEDDDEIDSDDENVDLYEYEEGVPEEESKKNNRYDRVDNYDYELPEDFEDENVESDDDEDGGNSENEEGEGDDDRHTRMLQGLTGMPSAAFQEESKKRPVLYTEAYPESEFNPTRDVLEGKGLISVEDLLAPLEGKPGFNDLNKRINRMQKDTQSVVHAPLPKPERERLERKAVKGLVEKDFNKWVHLVKRNREAPTVYFNQPVNVGYSTVGAIASEFQPRTEFEKKMASVLKDNELGEAHKEDGAKLLELNEVSMEDHIKYRDHIAKMRSLLFRHELKSKRIKKIKSKTYHRLKGKDLKKSAMGALMDPEMAKEEAIKQETRRVEERMTLKHKNTGKWAKRMLSRGLTERYDGTRAAISEQLQINATLSRKMNSTNDGSSSDESDDEEELSCGSDQDTPSKLIAKAREKTLKTMEDDDVPNSGLLSLPFMARAMKKKNEEANEEAKRAFGEYKELENFGGEDNPKKSADVSGRRVFGATSKVEAPKESKKDSDNFYDNSDSDNDMEGIENNDLGAVGDTASPARNTGAITETEKCCGDVENPASKTTFDVALFASGSWKKMKGSQNAESKKAPKTRVPISKGQDKKESRDEESEDSESEAEQMVDGILTSASKETYEIPSQAELIQRAFAGDDVVEEFEKDKQEVLNQEVPEPEKPVLVPGWGQWTNVQKKRGLPSWMVREHEDANKKRKLDLKTRKDYRLRNVIISEKVDKKADKLHTTTLPFPYTSKEVFEHSMRMPIGPEFNPATIVGALNRPEVVKKAGVIIKPVKFEEVNPNEKADDENPRSHQKQRPKKGSKTSKGQGKNKSKLKTKA", "length": 855 }, "evidence": [ { "id": "Q3T0Q8", "url": "https://omabrowser.org/oma/group/Q3T0Q8/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q04500-1", "protein_name": "U3 small nucleolar RNA-associated protein 14", "gene_name": "UTP14", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAKKKSKSRSKSSRRVLDALQLAEREINGEFDNSSDNDKRHDARRNGTVVNLLKRSKGDTNSDEDDIDSESFEDEELNSDEALGSDDDYDILNSKFSQTIRDKKENANYQEEEDEGGYTSIDEEDLMPLSQVWDMDEKTAQSNGNDDEDASPQLKLQDTDISSESSSSEESESESEDDEEEEDPFDEISEDEEDIELNTITSKLIDETKSKAPKRLDTYGSGEANEYVLPSANAASGASGKLSLTDMMNVIDDRQVIENANLLKGKSSTYEVPLPQRIQQRHDRKAAYEISRQEVSKWNDIVQQNRRADHLIFPLNKPTEHNHASAFTRTQDVPQTELQEKVDQVLQESNLANPEKDSKFEELSTAKMTPEEMRKRTTEMRLMRELMFREERKARRLKKIKSKTYRKIKKKELMKNRELAAVSSDEDNEDHDIARAKERMTLKHKTNSKWAKDMIKHGMTNDAETREEMEEMLRQGERLKAKMLDRNSDDEEDGRVQTLSDVENEEKENIDSEALKSKLGKTGVMNMAFMKNGEAREREANKETLRQLRAVENGDDIKLFESDEEETNGENIQINKGRRIYTPGSLESNKDMNELNDHTRKENKVDESRSLENRLRAKNSGQSKNARTNAEGAIIVEEESDGEPLQDGQNNQQDEEAKDVNPWLANESDEEHTVKKQSSKVNVIDKDSSKNVKAMNKMEKAELKQKKKKKGKSNDDEDLLLTADDSTRLKIVDPYGGSDDEQGDNVFMFKQQDVIAEAFAGDDVVAEFQEEKKRVIDDEDDKEVDTTLPGWGEWAGAGSKPKNKKRKFIKKVKGVVNKDKRRDKNLQNVIINEKVNKKNLKYQSSAVPFPFENREQYERSLRMPIGQEWTSRASHQELIKPRIMTKPGQVIDPLKAPFK", "length": 899 }, "evidence": [ { "id": "Q3T0Q8", "url": "https://omabrowser.org/oma/group/Q3T0Q8/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q640M1-1", "protein_name": "U3 small nucleolar RNA-associated protein 14 homolog A", "gene_name": "Utp14a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNSIKATKGLLALSQQDDLMDLTSNYPLSASEDEGDSDGERKHQKLLEAIGSLSGKNRWKLPERSEAGLKVSEFNVSSEGSGEKLALSDLLGPLKPSSSLAAVKKQLSRVKSKKTLELPLHKREVEQIHREVAFSKTSQTLSKWDSVVQKNREAEQLVFPLEKEPSSFAPMEHVFREWKARTPLEQEVFNLLHKNKQPVTDPLLTPVEKASLKAMSLEEAKIRRAELQRARALQSYYEARARRMKKIKSKKYHKIVKKGKAKKALKDFEQLRKVDPDAALEELEKMEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVVSESEEEGGADEEEALVPDIVNEVQKTADGPNPWMLRSCSRDAKENEIQADSEQLPESAAHEFPENEENDKPVAEEDELLKELEKRRSLRKRSELNQAAEPLGNQETKDSTSQEVLSELRALSKKLSKENHLSKKQKKSPAKAVDLVWEEEPAPEEDEPLLLQRPERMRTLEELEELGKEDSLPNKERPRPSVEGEQVRRNPQNHSKGKNKKEQMISLQNLLTTRTPSVTSLALPTTVEELEDEGARDQKQMIKEAFAGDDVIKEFLKEKREAIQANKPKAVDLTLPGWGEWGGMNLKPSARKRRRFLIKAPEGPPRKDKNLPNVIISEKRNIHAAAHQVRVLPYPFTHHQQFERTIQNPIGSTWNTQRAFQKLTAPKVVTKPGHIIKPITAEDVDCRSSPRSDVPVMQSNPKQHSKHQKQRKKSSIG", "length": 767 }, "evidence": [ { "id": "Q3T0Q8", "url": "https://omabrowser.org/oma/group/Q3T0Q8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BVJ6-1", "protein_name": "U3 small nucleolar RNA-associated protein 14 homolog A", "gene_name": "UTP14A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTANRLAESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSKKTVELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRRRFLIKAPEGPPRKDKNLPNVIINEKRNIHAAAHQVRVLPYPFTHHWQFERTIQTPIGSTWNTQRAFQKLTTPKVVTKPGHIINPIKAEDVGYRSSSRSDLSVIQRNPKRITTRHKKQLKKCSVD", "length": 771 }, "evidence": [ { "id": "Q3T0Q8", "url": "https://omabrowser.org/oma/group/Q3T0Q8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VUR2-1", "protein_name": "U3 small nucleolar RNA-associated protein 14 homolog A", "gene_name": "Dmel\\CG12301", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSDDEEHYEPKAHKKLLQAIGSLGKVQHIQKSTRDERQSLQDEFQLVKGVSSAETDHAPRAVGLNDLVDILRTSTKHSQTGKKLKNIHGSKKVLQKPLEKPAADRIKRTIGYEGVTKKLGRWDAVVAQQRSAETQIFPLPSETVYVNTAANARPLNTRVKSNLAQELEANNRKLRELRKAQIGDTTDEKELAKQERLLLQKKLTRDELFARRKELAYLKMRESQKSAKARMQNKIKSKKFHKLQKRQKMLEQMKEFELLQKTDPEAALEKLNALEKSRVQERASLRHKNTGTWAKNLQIRAKYDKDVRKDLAEQLAVSRELTQKKQVSDSEDETTKKRVLPEEEDNDYDPFNPWTKRKATEQTENGNGESEGSNWRQYWTKRNKNEKLLEEHRRDLEGVQDNDEQEEKETIRKPLIEVKPAKKKLKKSKVKIENGWEVEDICPTDQKEAKASPNSKAIDDIFEKHEDHIRAKLNKKMEKLRERINKLKEVPVKGKKAKKKDVLQNLKSLALKKTKQQIEIDEPLNYEEDKNSQNNIPAHVEGNTESTEIPAVDTIDPNKVTTLVFTQKKGNSGGFNDALIDDEAAEYDEEDAAAERQLTISQAFEDDDIVADFNRDKSKDSELKNTELQLALPGWGSWAGAGISKEVMERRNKRLLLKLAAPEKRRDENKDNLYLNESASKQARQHMVSSIPFPFRSLADYEASIRAPVGRNFVPETAFRMLTRPAVITRKGQVIEPMTESELVKPDRRLRHIVDRRIKRIPKVPPKAKIA", "length": 771 }, "evidence": [ { "id": "Q3T0Q8", "url": "https://omabrowser.org/oma/group/Q3T0Q8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q8", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8" } ], "pmid": "" }, { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q8", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Q8", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 136, "end_pos": 138, "annotation": "n_glycosylation_sequon" }, { "start_pos": 539, "end_pos": 541, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0Q8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 770, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0Q8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0Q8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 30, 32, 53, 78, 82, 206, 406, 408, 453, 567 ], "sequon_annotation_sites": [ { "start_pos": 136, "end_pos": 138 }, { "start_pos": 539, "end_pos": 541 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 10 }, { "field": "total_sites", "count": 10 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3T0R4-1", "uniprot_ac": "Q3T0R4", "uniprot_id": "PEXRP_BOVIN", "mass": { "chemical_mass": 35032.0, "monoisotopic_mass": 35032.0 }, "refseq": { "ac": "NP_001030420", "name": "peroxisomal reductase activating PPAR-gamma", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030420" }, "gene_names": [ { "name": "DHRS7B", "type": "recommended", "evidence": [ { "id": "Q3T0R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4" } ] }, { "name": "DHRS7B", "type": "synonym", "evidence": [ { "id": "NP_001030420", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030420" } ] }, { "name": "PexRAP", "type": "synonym", "evidence": [ { "id": "NP_001030420", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030420" } ] }, { "name": "SDR32C1", "type": "synonym", "evidence": [ { "id": "Q3T0R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4" } ] } ], "protein_names": [ { "name": "Peroxisomal reductase activating PPAR-gamma", "type": "recommended", "evidence": [ { "id": "Q3T0R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4/entry#names_and_taxonomy" } ] }, { "name": "1.1.1.101", "type": "synonym", "evidence": [ { "id": "Q3T0R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4/entry#names_and_taxonomy" } ] }, { "name": "Dehydrogenase/reductase SDR family member 7B", "type": "synonym", "evidence": [ { "id": "Q3T0R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4/entry#names_and_taxonomy" } ] }, { "name": "PexRAP", "type": "synonym", "evidence": [ { "id": "Q3T0R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4/entry#names_and_taxonomy" } ] }, { "name": "Protein SDR32C1", "type": "synonym", "evidence": [ { "id": "Q3T0R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4/entry#names_and_taxonomy" } ] }, { "name": "Short-chain dehydrogenase/reductase family 32C member 1", "type": "synonym", "evidence": [ { "id": "Q3T0R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4/entry#names_and_taxonomy" } ] }, { "name": "dehydrogenase/reductase SDR family member 7B", "type": "synonym", "evidence": [ { "id": "NP_001030420", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030420" } ] }, { "name": "peroxisomal reductase activating PPAR-gamma", "type": "synonym", "evidence": [ { "id": "NP_001030420", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030420" } ] }, { "name": "short-chain dehydrogenase/reductase family 32C member 1", "type": "synonym", "evidence": [ { "id": "NP_001030420", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030420" } ] } ], "function": [ { "annotation": "Reductase required for adipogenesis and activation of PPARG nuclear receptor. Can convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively, synthesizing ether-linked phospholipids that act as agonists for PPARG. Also regulates adipogenesis by preventing adipocyte browning: following import into the nucleus, interacts with PRDM16, inhibiting the interaction between PRDM16 and PPARG and preventing differentiation of brown adipocytes.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0R4", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4#function" }, { "database": "UniProtKB", "id": "Q99J47", "url": "https://www.uniprot.org/uniprotkb/Q99J47#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0R4", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DHRS7B", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4", "locus": { "chromosome": "19", "start_pos": 35212185, "end_pos": 35165054, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010559", "url": "https://www.ensembl.org/id/ENSBTAG00000010559" } ] } } ], "crossref": [ { "id": "Q3T0R4", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0R4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd05332", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05332", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "522283", "url": "https://www.ncbi.nlm.nih.gov/gene/522283", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057326", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057326", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522283", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522283", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T0R4", "url": "https://www.orthodb.org/?gene=Q3T0R4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44196", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44196", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44196:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44196:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00106", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00106", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030420", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17341", "url": "https://www.rhea-db.org/rhea/17341", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "36175", "url": "https://www.rhea-db.org/rhea/36175", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T0R4", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0R4-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSAATRKSLLRARVMDFITSTAILPLLLGCVGLFSLFKLLQWLRMRAYVRNAVVVITGATSGLGRECARVFHAAGARLVLCGRNAEALEELSQELAASRAPGVQTHKPCTVTFDLADPGAIAGAASEILQCFGHVDVLINNAGISYRGAIVDTSPDVDKRVMETNYFGPVALTKALLPAMIRRRQGHVVAISSIQGKISLPFRSAYAASKHATQAFFDCLRAEVEQHDIEVTVISPGYIHTNLSLNAVTADGSKYGVMDETTAQGRSPVQVAQDILAALGKKKKDVVLADPMPSLAVYLRTLAPGLFFRLMASRARKERKSKHS", "length": 325, "header": "sp|Q3T0R4-1|PEXRP_BOVIN Isoform 1 of Peroxisomal reductase activating PPAR-gamma OS=Bos taurus OX=9913 GN=DHRS7B PE=2 SV=1 CANONICAL=Q3T0R4-1" }, "isoforms": [ { "isoform_ac": "Q3T0R4-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4/entry#Q3T0R4-1", "sequence": { "sequence": "MVSAATRKSLLRARVMDFITSTAILPLLLGCVGLFSLFKLLQWLRMRAYVRNAVVVITGATSGLGRECARVFHAAGARLVLCGRNAEALEELSQELAASRAPGVQTHKPCTVTFDLADPGAIAGAASEILQCFGHVDVLINNAGISYRGAIVDTSPDVDKRVMETNYFGPVALTKALLPAMIRRRQGHVVAISSIQGKISLPFRSAYAASKHATQAFFDCLRAEVEQHDIEVTVISPGYIHTNLSLNAVTADGSKYGVMDETTAQGRSPVQVAQDILAALGKKKKDVVLADPMPSLAVYLRTLAPGLFFRLMASRARKERKSKHS", "length": 325, "header": "sp|Q3T0R4-1|PEXRP_BOVIN Isoform 1 of Peroxisomal reductase activating PPAR-gamma OS=Bos taurus OX=9913 GN=DHRS7B PE=2 SV=1 CANONICAL=Q3T0R4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:522283", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522283", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3T0R4", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4" } ], "pmid": "" }, { "name": "peroxisomal membrane", "id": "GO:0005778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005778", "evidence": [ { "database": "UniProtKB", "id": "Q3T0R4", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3T0R4", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3T0R4", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "Q3T0R4", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "acylglycerone-phosphate reductase (NADP+) activity", "id": "GO:0000140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000140", "evidence": [ { "database": "UniProtKB", "id": "Q3T0R4", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17341", "name": "", "equation": "1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0ABI0P6C2-1", "Q3T0R4-1" ], "evidence": [ { "id": "17341", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17341" } ] }, { "id": "36175", "name": "", "equation": "a 1-O-alkylglycerone 3-phosphate + NADPH + H(+) = a 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0ABI0P6C2-1", "Q3T0R4-1" ], "evidence": [ { "id": "36175", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36175" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0ABI0P6C2", "gene_name": "DHRS7B", "activity": [ { "ec_number": "1.1.1.101", "activity": "1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+).", "evidence": [ { "id": "A0ABI0P6C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6C2" } ] }, { "ec_number": "1.1.1.101", "activity": "", "evidence": [ { "id": "A0ABI0P6C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6C2" } ] } ] }, { "uniprot_ac": "Q3T0R4", "gene_name": "DHRS7B", "activity": [ { "ec_number": "1.1.1.101", "activity": "1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+).", "evidence": [ { "id": "Q3T0R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4" } ] }, { "ec_number": "1.1.1.101", "activity": "", "evidence": [ { "id": "Q3T0R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0R4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 325, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0R4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0R4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3T0R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R4" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Nuclear localization signal", "eco_id": "ECO_0000250", "start_pos": 255, "end_pos": 287, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.1.1.101", "ec_name": "1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+).", "evidence": [ { "id": "1.1.1.101", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.101" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 243, "end_pos": 245 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0T5-1", "uniprot_ac": "Q3T0T5", "uniprot_id": "JUPI1_BOVIN", "mass": { "chemical_mass": 16010.0, "monoisotopic_mass": 16010.0 }, "refseq": { "ac": "NP_001029906", "name": "jupiter microtubule associated homolog 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029906" }, "gene_names": [ { "name": "JPT1", "type": "recommended", "evidence": [ { "id": "Q3T0T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T5" } ] }, { "name": "HN1", "type": "synonym", "evidence": [ { "id": "NP_001029906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029906" }, { "id": "Q3T0T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T5" } ] }, { "name": "JPT1", "type": "synonym", "evidence": [ { "id": "NP_001029906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029906" } ] } ], "protein_names": [ { "name": "Jupiter microtubule associated homolog 1", "type": "recommended", "evidence": [ { "id": "Q3T0T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T5/entry#names_and_taxonomy" } ] }, { "name": "Hematological and neurological expressed 1 protein", "type": "synonym", "evidence": [ { "id": "Q3T0T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0T5/entry#names_and_taxonomy" } ] }, { "name": "hematological and neurological expressed 1 protein", "type": "synonym", "evidence": [ { "id": "NP_001029906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029906" } ] }, { "name": "jupiter microtubule associated homolog 1", "type": "synonym", "evidence": [ { "id": "NP_001029906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029906" } ] } ], "function": [ { "annotation": "Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0T5", "url": "https://www.uniprot.org/uniprotkb/Q3T0T5#function" }, { "database": "UniProtKB", "id": "Q9UK76", "url": "https://www.uniprot.org/uniprotkb/Q9UK76#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0T5", "url": "https://www.uniprot.org/uniprotkb/Q3T0T5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "JPT1", "url": "https://www.uniprot.org/uniprotkb/Q3T0T5", "locus": { "chromosome": "19", "start_pos": 56316476, "end_pos": 56301994, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000061800", "url": "https://www.ensembl.org/id/ENSBTAG00000061800" } ] } } ], "crossref": [ { "id": "Q3T0T5", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0T5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030170", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030170", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613381", "url": "https://www.ncbi.nlm.nih.gov/gene/613381", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR033335", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033335", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613381", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613381", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KGEGNIH", "url": "https://omabrowser.org/oma/group/KGEGNIH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0T5", "url": "https://www.orthodb.org/?gene=Q3T0T5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34930", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34930", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34930:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34930:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001029906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029906", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0T5", "url": "https://www.uniprot.org/uniprotkb/Q3T0T5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0T5-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0T5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTTTTFKGVDPNSRNSSRVLRPPGGGSNFSLGFDEPTEQPVRRNKMASSIFGTPEENPPSWAKSAGAKSSGGREDAESSGPQRRNSSEANSGDFLDLKGEGDVHENVDTDLQASLGQSEEKPVPAAPVPSPVAPAPVPSRRNPPGGKSSLVLG", "length": 154, "header": "sp|Q3T0T5-1|JUPI1_BOVIN Isoform 1 of Jupiter microtubule 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"https://www.uniprot.org/uniprotkb/Q3T0T5" } ], "site_lbl": "Thr54" }, { "start_pos": 71, "end_pos": 71, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0T5", "url": "https://www.uniprot.org/uniprotkb/Q3T0T5" } ], "site_lbl": "Ser71" }, { "start_pos": 80, "end_pos": 80, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0T5", "url": "https://www.uniprot.org/uniprotkb/Q3T0T5" } ], "site_lbl": "Ser80" }, { "start_pos": 87, "end_pos": 87, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0T5", "url": "https://www.uniprot.org/uniprotkb/Q3T0T5" } ], "site_lbl": "Ser87" }, { "start_pos": 88, "end_pos": 88, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0T5", "url": "https://www.uniprot.org/uniprotkb/Q3T0T5" } ], "site_lbl": "Ser88" }, { "start_pos": 92, "end_pos": 92, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0T5", "url": "https://www.uniprot.org/uniprotkb/Q3T0T5" } ], "site_lbl": "Ser92" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613381", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613381", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3T0T5", "url": "https://www.uniprot.org/uniprotkb/Q3T0T5" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3T0T5", "url": "https://www.uniprot.org/uniprotkb/Q3T0T5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3T0T5", "url": "https://www.uniprot.org/uniprotkb/Q3T0T5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" }, { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" }, { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0T5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 154, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0T5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0T5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 28, 31, 54, 71, 80, 87, 88, 92, 131 ], "sequon_annotation_sites": [ { "start_pos": 16, "end_pos": 18 }, { "start_pos": 29, "end_pos": 31 }, { "start_pos": 86, "end_pos": 88 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { 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"table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 9 }, { "field": "total_sites", "count": 9 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0U1-1", "uniprot_ac": "Q3T0U1", "uniprot_id": "MESD_BOVIN", "mass": { "chemical_mass": 25977.0, "monoisotopic_mass": 25977.0 }, "refseq": { "ac": "NP_001029641", "name": "LRP chaperone MESD precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029641" }, "gene_names": [ { "name": "MESD", "type": "recommended", "evidence": [ { "id": "Q3T0U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0U1" } ] }, { "name": "MESDC2", "type": "synonym", "evidence": [ { "id": "NP_001029641", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029641" }, { "id": "Q3T0U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0U1" } ] }, { "name": "MESD", "type": "synonym", "evidence": [ { "id": "NP_001029641", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029641" } ] } ], "protein_names": [ { "name": "LRP chaperone MESD", "type": "recommended", "evidence": [ { "id": "Q3T0U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0U1/entry#names_and_taxonomy" } ] }, { "name": "LDLR chaperone MESD", "type": "synonym", "evidence": [ { "id": "NP_001029641", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029641" }, { "id": "Q3T0U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0U1/entry#names_and_taxonomy" } ] }, { "name": "LRP chaperone MESD precursor", "type": "synonym", "evidence": [ { "id": "NP_001029641", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029641" } ] }, { "name": "LRP chaperone MESD", "type": "synonym", "evidence": [ { "id": "NP_001029641", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029641" } ] }, { "name": "Mesoderm development candidate 2", "type": "synonym", "evidence": [ { "id": "Q3T0U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0U1/entry#names_and_taxonomy" } ] }, { "name": "Mesoderm development protein", "type": "synonym", "evidence": [ { "id": "Q3T0U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0U1/entry#names_and_taxonomy" } ] }, { "name": "mesoderm development candidate 2", "type": "synonym", "evidence": [ { "id": "NP_001029641", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029641" } ] }, { "name": "mesoderm development protein", "type": "synonym", "evidence": [ { "id": "NP_001029641", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029641" } ] } ], "function": [ { "annotation": "Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0U1", "url": "https://www.uniprot.org/uniprotkb/Q3T0U1#function" }, { "database": "UniProtKB", "id": "Q9ERE7", "url": "https://www.uniprot.org/uniprotkb/Q9ERE7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0U1", "url": "https://www.uniprot.org/uniprotkb/Q3T0U1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MESD", "url": "https://www.uniprot.org/uniprotkb/Q3T0U1", "locus": { "chromosome": "21", "start_pos": 26812705, "end_pos": 26830057, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001565", "url": "https://www.ensembl.org/id/ENSBTAG00000001565" } ] } } ], "crossref": [ { "id": "Q3T0U1", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0U1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001565", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001565", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514610", "url": "https://www.ncbi.nlm.nih.gov/gene/514610", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514610", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514610", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QQRCADV", "url": "https://omabrowser.org/oma/group/QQRCADV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0U1", "url": "https://www.orthodb.org/?gene=Q3T0U1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR17600", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17600", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR17600:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17600:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10185", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10185", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029641", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029641", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0U1", "url": "https://www.uniprot.org/uniprotkb/Q3T0U1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0U1-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0U1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASGWARAAVIFLCACDLLLLLLLPPRAFATEGPAETPGEATPPPRKKKKDIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPIDFSQIDPGKPESILKMTKKGKTLMMFVTVSGNPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGGYAWEIKDFLVSQDRCADVTLEGQVYPGKGGGSKEKNQTKQEKGKKKKERDLKPRASKEDNRAGSKKEEL", "length": 232, "header": "sp|Q3T0U1-1|MESD_BOVIN Isoform 1 of LRP chaperone MESD OS=Bos taurus OX=9913 GN=MESD PE=2 SV=1 CANONICAL=Q3T0U1-1" }, "isoforms": [ { "isoform_ac": "Q3T0U1-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0U1/entry#Q3T0U1-1", "sequence": { "sequence": "MAASGWARAAVIFLCACDLLLLLLLPPRAFATEGPAETPGEATPPPRKKKKDIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPIDFSQIDPGKPESILKMTKKGKTLMMFVTVSGNPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGGYAWEIKDFLVSQDRCADVTLEGQVYPGKGGGSKEKNQTKQEKGKKKKERDLKPRASKEDNRAGSKKEEL", "length": 232, "header": "sp|Q3T0U1-1|MESD_BOVIN Isoform 1 of LRP chaperone MESD OS=Bos taurus OX=9913 GN=MESD PE=2 SV=1 CANONICAL=Q3T0U1-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 199, "start_aa": "Asn", "end_pos": 199, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn199", "evidence": [ { "id": "Q3T0U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0U1#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 43, "start_aa": "Thr", "end_pos": 43, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr43", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:514610", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514610", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A1L243-1", "protein_name": "LRP chaperone MESD", "gene_name": "mesd", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MASSVGCRTLSVLFLLVLFITVHCTDTKPKKKKDIRDYNDADMARLLEEWEKDDDIEEGDLPEHKRSPPPIDFSKIDASKPEELLKMSKKGKTLMVFASVSGNPTEKETEEITGLWQGSLFNANYDVQRFVVGSNRVIFMLRDGSYAWEIKDFLVSQDRCEDVTVEGQVFPGKNAKKDAKGKEQNETKKKGDKKAANRANKGKQEL", "length": 206 }, "evidence": [ { "id": "Q3T0U1", "url": "https://omabrowser.org/oma/group/Q3T0U1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1RIE0-1", "protein_name": "LRP chaperone MESD", "gene_name": "MESD", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAASAWARTAVVLLCVSDLLLLVLLPPRAFAAEGPAKTPSEATPPPRKKKKDIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPIDFSQIDPGKPESILKMTKKGKTLMMFVTVSGNPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWEIKDFLVSQDRCADVTLEGQVYPGKGGGSKEKNKTKQEKGKKKKEGDSKSRASKDDNRAGSQRQEL", "length": 232 }, "evidence": [ { "id": "Q3T0U1", "url": "https://omabrowser.org/oma/group/Q3T0U1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3I9P1-1", "protein_name": "LRP chaperone MESD", "gene_name": "Mesd", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAASSWLCAVLLFLCASDLLLLPPPGACAADTPGEATPPPRKKKKDIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPVDFSKLDPGKPESILKMTKKGKTLMMFVTVSGNPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWEIKDFLVSQDRCADVTLEGQVYPGKGGGSKEKNKTKPEKGKKKKEGDAKPRASKEDNRAGSRREDL", "length": 226 }, "evidence": [ { "id": "Q3T0U1", "url": "https://omabrowser.org/oma/group/Q3T0U1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q14696-1", "protein_name": "LRP chaperone MESD", "gene_name": "MESD", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAASRWARKAVVLLCASDLLLLLLLLPPPGSCAAEGSPGTPDESTPPPRKKKKDIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPVDFSKIDPSKPESILKMTKKGKTLMMFVTVSGSPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWEIKDFLVGQDRCADVTLEGQVYPGKGGGSKEKNKTKQDKGKKKKEGDLKSRSSKEENRAGNKREDL", "length": 234 }, "evidence": [ { "id": "Q3T0U1", "url": "https://omabrowser.org/oma/group/Q3T0U1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5U2R7-1", "protein_name": "LRP chaperone MESD", "gene_name": "Mesd", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAASSWLRAVLLFLCASDLLLLSPPEAYATDTPGEAITPPRKKKDIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPIDFSKLDPGKPESILKMTKKGKTLMMFVTISGNPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWEIKDFLVNQDRCAEVTLEGQMYPGKGGGSKEKNKTKPEKGKKKEGDPKPRASKEDNRAGSRREDL", "length": 224 }, 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}, { "name": "E3 ubiquitin-protein ligase RNF181", "type": "synonym", "evidence": [ { "id": "NP_001029682", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029682" } ] }, { "name": "RING finger protein 181", "type": "synonym", "evidence": [ { "id": "Q3T0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0W3/entry#names_and_taxonomy" } ] }, { "name": "RING-type E3 ubiquitin transferase RNF181", "type": "synonym", "evidence": [ { "id": "NP_001029682", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029682" } ] } ], "function": [ { "annotation": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W3", "url": "https://www.uniprot.org/uniprotkb/Q3T0W3#function" }, { "database": "UniProtKB", "id": "Q9P0P0", "url": "https://www.uniprot.org/uniprotkb/Q9P0P0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0W3", "url": "https://www.uniprot.org/uniprotkb/Q3T0W3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RNF181", "url": "https://www.uniprot.org/uniprotkb/Q3T0W3", "locus": { "chromosome": "11", "start_pos": 49405530, "end_pos": 49413440, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018286", "url": "https://www.ensembl.org/id/ENSBTAG00000018286" } ] } } ], "crossref": [ { "id": "Q3T0W3", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0W3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018286", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018286", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16669", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16669", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515743", "url": "https://www.ncbi.nlm.nih.gov/gene/515743", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515743", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515743", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EHLHGAM", "url": "https://omabrowser.org/oma/group/EHLHGAM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T0W3", "url": "https://www.orthodb.org/?gene=Q3T0W3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15710", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15710", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15710:SF160", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15710:SF160", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13639", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13639", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8866654", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8866654", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029682", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0W3", "url": "https://www.uniprot.org/uniprotkb/Q3T0W3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0W3-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0W3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASYFDEHDCEPLDRERDPRTNMLLELARSLFNRMDFEDLGLVVDWDHHLPPPAAKTAVENLPRTVIRGSQAELKCPVCLLEFEEEETAIEMPCHHLFHSNCILPWLSKTNSCPLCRHELPTDDDTYEEHKRDKARKQQQKHRLENLHGAMYT", "length": 153, "header": "sp|Q3T0W3-1|RN181_BOVIN Isoform 1 of E3 ubiquitin-protein ligase RNF181 OS=Bos taurus OX=9913 GN=RNF181 PE=2 SV=1 CANONICAL=Q3T0W3-1" }, "isoforms": [ { "isoform_ac": "Q3T0W3-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0W3/entry#Q3T0W3-1", "sequence": { "sequence": "MASYFDEHDCEPLDRERDPRTNMLLELARSLFNRMDFEDLGLVVDWDHHLPPPAAKTAVENLPRTVIRGSQAELKCPVCLLEFEEEETAIEMPCHHLFHSNCILPWLSKTNSCPLCRHELPTDDDTYEEHKRDKARKQQQKHRLENLHGAMYT", "length": 153, "header": "sp|Q3T0W3-1|RN181_BOVIN Isoform 1 of E3 ubiquitin-protein ligase RNF181 OS=Bos taurus OX=9913 GN=RNF181 PE=2 SV=1 CANONICAL=Q3T0W3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 153, "end_pos": 153, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W3", "url": "https://www.uniprot.org/uniprotkb/Q3T0W3" } ], "site_lbl": "Thr153" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:515743", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515743", "resource": "KEGG Pathway" }, { "id": "R-BTA-8866654", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8866654", "resource": "Reactome", "description": "E3 ubiquitin ligases ubiquitinate target proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7JR21-1", "protein_name": "E3 ubiquitin-protein ligase RNF181", "gene_name": "Rnf181", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASYFDEHDCEPLNPEREARNNMLLELARRVRGAWSWAPGSRSLFNRMDFEDLGLVDWEHHLPPPAAKAVVESLPRTVIGSSKAELKCPVCLLEFEEEETVIEMPCRHLFHSSCILPWLSKTNSCPLCRHELPTDDDSYEEHKKDKPVVFLPGSEAAAAAPSGESPRSHVHVRQRLGLRAQPL", "length": 183 }, "evidence": [ { "id": "Q3T0W3", "url": "https://omabrowser.org/oma/group/Q3T0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6AXU4-1", "protein_name": "E3 ubiquitin-protein ligase RNF181", "gene_name": "Rnf181", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASYFDEHDCEPLNPEREARNNMLLELARRVRGAWSWAPGSRSLFNRMDFEDLGLVDWEHHLPPPAAKAVVESLPRTVIRSSKAELKCPVCLLEFEEEETVIEMPCHHLFHSNCILPWLSKTNSCPLCRHELPTDDDSYEEHKKDKARRQQQQHRLENLHGAMYT", "length": 165 }, "evidence": [ { "id": "Q3T0W3", "url": "https://omabrowser.org/oma/group/Q3T0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7ZW78-1", "protein_name": "E3 ubiquitin-protein ligase RNF181", "gene_name": "rnf181", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MASYFDEHDCEPTNPEEQYRQNALLELARSLMQGLDIDSGSFDLSDWDQRLPPPAAKAVVQSLPVVIISPEQADKGVKCPVCLLEFEEQESVREMPCKHLFHTGCILPWLNKTNSCPLCRLELPTDNADYEEFKKDKERRRQREHRLEDLHGAMYT", "length": 156 }, "evidence": [ { "id": "Q3T0W3", "url": "https://omabrowser.org/oma/group/Q3T0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9CY62-1", "protein_name": "E3 ubiquitin-protein ligase RNF181", "gene_name": "Rnf181", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASYFDEHDCEPLNPEREARNNMLLELARRVRGAWSWAPGGRSLFNRMDFEDLGLVDWEHHLPPPAAKAVVESLPRTVISSAKADLKCPVCLLEFEAEETVIEMPCHHLFHSNCILPWLSKTNSCPLCRHELPTDDDSYEEHKKDKARRQQQQHRLENLHGAMYT", "length": 165 }, "evidence": [ { "id": "Q3T0W3", "url": "https://omabrowser.org/oma/group/Q3T0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P0P0-1", "protein_name": "E3 ubiquitin-protein ligase RNF181", "gene_name": "RNF181", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASYFDEHDCEPSDPEQETRTNMLLELARSLFNRMDFEDLGLVVDWDHHLPPPAAKTVVENLPRTVIRGSQAELKCPVCLLEFEEEETAIEMPCHHLFHSSCILPWLSKTNSCPLCRYELPTDDDTYEEHRRDKARKQQQQHRLENLHGAMYT", "length": 153 }, "evidence": [ { "id": "Q3T0W3", "url": "https://omabrowser.org/oma/group/Q3T0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W3", "url": "https://www.uniprot.org/uniprotkb/Q3T0W3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W3", "url": "https://www.uniprot.org/uniprotkb/Q3T0W3" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W3", "url": "https://www.uniprot.org/uniprotkb/Q3T0W3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W3", "url": "https://www.uniprot.org/uniprotkb/Q3T0W3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-8939323", "name": "RNF181 binds BCL10 and Ubiquitin:E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0P5K3-1", "Q1RMX2-1", "Q2TA10-1", "A0A3Q1MAR8-1", "Q3T0W3-1" ], "evidence": [ { "id": "R-BTA-8939323", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8939323" } ] }, { "id": "R-BTA-8939335", "name": "RNF181 polyubiquinates BCL10", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0P5K3-1", "Q1RMX2-1", "Q2TA10-1", "A0A3Q1MAR8-1", "Q3T0W3-1" ], "evidence": [ { "id": "R-BTA-8939335", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8939335" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MAR8", "gene_name": "UBE2E1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] } ] }, { "uniprot_ac": "Q0P5K3", "gene_name": "UBE2N", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] } ] }, { "uniprot_ac": "Q1RMX2", "gene_name": "UBE2D2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] } ] }, { "uniprot_ac": "Q2TA10", "gene_name": "UBE2D1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] } ] }, { "uniprot_ac": "Q3T0W3", "gene_name": "RNF181", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3T0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0W3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q3T0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0W3" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0W3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 153, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0W3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0W3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 153 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0W7-1", "uniprot_ac": "Q3T0W7", "uniprot_id": "ATG12_BOVIN", "mass": { "chemical_mass": 15285.0, "monoisotopic_mass": 15285.0 }, "refseq": { "ac": "NP_001070450", "name": "ubiquitin-like protein ATG12", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070450" }, "gene_names": [ { "name": "ATG12", "type": "recommended", "evidence": [ { "id": "Q3T0W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7" } ] }, { "name": "ATG12", "type": "synonym", "evidence": [ { "id": "NP_001070450", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070450" } ] } ], "protein_names": [ { "name": "Ubiquitin-like protein ATG12", "type": "recommended", "evidence": [ { "id": "Q3T0W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7/entry#names_and_taxonomy" } ] }, { "name": "APG12-like", "type": "synonym", "evidence": [ { "id": "Q3T0W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7/entry#names_and_taxonomy" } ] }, { "name": "ATG12 autophagy related 12 homolog", "type": "synonym", "evidence": [ { "id": "NP_001070450", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070450" } ] }, { "name": "Autophagy-related protein 12", "type": "synonym", "evidence": [ { "id": "Q3T0W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7/entry#names_and_taxonomy" } ] }, { "name": "autophagy-related protein 12", "type": "synonym", "evidence": [ { "id": "NP_001070450", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070450" } ] }, { "name": "ubiquitin-like protein ATG12", "type": "synonym", "evidence": [ { "id": "NP_001070450", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070450" } ] } ], "function": [ { "annotation": "Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus (By similarity). As part of the ATG8 conjugation system with ATG5 and ATG16L1, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W7", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7#function" }, { "database": "UniProtKB", "id": "Q9CQY1", "url": "https://www.uniprot.org/uniprotkb/Q9CQY1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0W7", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ATG12", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7", "locus": { "chromosome": "10", "start_pos": 4680213, "end_pos": 4702700, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017525", "url": "https://www.ensembl.org/id/ENSBTAG00000017525" } ] } } ], "crossref": [ { "id": "Q3T0W7", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0W7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01612", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01612", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "767903", "url": "https://www.ncbi.nlm.nih.gov/gene/767903", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007242", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007242", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767903", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767903", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T0W7", "url": "https://www.orthodb.org/?gene=Q3T0W7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13385", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13385", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13385:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13385:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04110", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04110", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070450", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0W7", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0W7-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEEQESALQLPPSTAPEAEVPTEVSPETATPEPPSSAAVSPGTEEPVGDTKKKIDILLKAVGDTPIMKTKKWAVERTRTIQGLFDFIKKFLKLVASEQLFIYVNQSFAPSPDQEVGTLYECFGSDGKLVLHYCKSQAWG", "length": 140, "header": "sp|Q3T0W7-1|ATG12_BOVIN Isoform 1 of Ubiquitin-like protein ATG12 OS=Bos taurus OX=9913 GN=ATG12 PE=2 SV=1 CANONICAL=Q3T0W7-1" }, "isoforms": [ { "isoform_ac": "Q3T0W7-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7/entry#Q3T0W7-1", "sequence": { "sequence": "MAEEQESALQLPPSTAPEAEVPTEVSPETATPEPPSSAAVSPGTEEPVGDTKKKIDILLKAVGDTPIMKTKKWAVERTRTIQGLFDFIKKFLKLVASEQLFIYVNQSFAPSPDQEVGTLYECFGSDGKLVLHYCKSQAWG", "length": 140, "header": "sp|Q3T0W7-1|ATG12_BOVIN Isoform 1 of Ubiquitin-like protein ATG12 OS=Bos taurus OX=9913 GN=ATG12 PE=2 SV=1 CANONICAL=Q3T0W7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767903", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767903", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "autophagosome maturation", "id": "GO:0097352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097352", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W7", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7" } ], "pmid": "" }, { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W7", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W7", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7" } ], "pmid": "" }, { "name": "autophagy of mitochondrion", "id": "GO:0000422", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000422", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W7", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7" } ], "pmid": "" }, { "name": "piecemeal microautophagy of the nucleus", "id": "GO:0034727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034727", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W7", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7" } ], "pmid": "" }, { "name": "glycophagy", "id": "GO:0061723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061723", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W7", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "autophagosome membrane", "id": "GO:0000421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000421", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W7", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7" } ], "pmid": "" }, { "name": "phagophore assembly site membrane", "id": "GO:0034045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034045", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W7", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7" } ], "pmid": "" }, { "name": "Atg12-Atg5-Atg16 complex", "id": "GO:0034274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034274", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W7", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein tag activity", "id": "GO:0031386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031386", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W7", "url": "https://www.uniprot.org/uniprotkb/Q3T0W7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 105, "end_pos": 107, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0W7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 140, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0W7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0W7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 105, "end_pos": 107 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", 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"sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0W9-1", "uniprot_ac": "Q3T0W9", "uniprot_id": "RL19_BOVIN", "mass": { "chemical_mass": 23466.0, "monoisotopic_mass": 23466.0 }, "refseq": { "ac": "NP_001035606", "name": "large ribosomal subunit protein eL19", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035606" }, "gene_names": [ { "name": "RPL19", "type": "recommended", "evidence": [ { "id": "Q3T0W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0W9" } ] }, { "name": "RPL19", "type": "synonym", "evidence": [ { "id": "NP_001035606", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035606" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein eL19", "type": "recommended", "evidence": [ { "id": "Q3T0W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0W9/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L19", "type": "synonym", "evidence": [ { "id": "NP_001035606", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035606" }, { "id": "Q3T0W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0W9/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein eL19", "type": "synonym", "evidence": [ { "id": "NP_001035606", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035606" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W9", "url": "https://www.uniprot.org/uniprotkb/Q3T0W9#function" }, { "database": "UniProtKB", "id": "P84098", "url": "https://www.uniprot.org/uniprotkb/P84098#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0W9", "url": "https://www.uniprot.org/uniprotkb/Q3T0W9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL19", "url": "https://www.uniprot.org/uniprotkb/Q3T0W9", "locus": { "chromosome": "19", "start_pos": 39697793, "end_pos": 39694197, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002060", "url": "https://www.ensembl.org/id/ENSBTAG00000002060" } ] } } ], 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"MSMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLIKDGLIIRKPVTVHSRARCRKNTLARRKGRHMGIGKRKGTANARMPEKVTWMRRMRILRRLLRRYRESKKIDRHMYHSLYLKVKGNVFKNKRILMEHIHKLKADKARKKLLADQAEARRSKTKEARKRREERLQAKKEEIIKTLSKEEETKK", "length": 196, "header": "sp|Q3T0W9-1|RL19_BOVIN Isoform 1 of Large ribosomal subunit protein eL19 OS=Bos taurus OX=9913 GN=RPL19 PE=1 SV=1 CANONICAL=Q3T0W9-1" }, "isoforms": [ { "isoform_ac": "Q3T0W9-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0W9/entry#Q3T0W9-1", "sequence": { "sequence": "MSMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLIKDGLIIRKPVTVHSRARCRKNTLARRKGRHMGIGKRKGTANARMPEKVTWMRRMRILRRLLRRYRESKKIDRHMYHSLYLKVKGNVFKNKRILMEHIHKLKADKARKKLLADQAEARRSKTKEARKRREERLQAKKEEIIKTLSKEEETKK", "length": 196, "header": "sp|Q3T0W9-1|RL19_BOVIN Isoform 1 of Large ribosomal subunit protein eL19 OS=Bos taurus OX=9913 GN=RPL19 PE=1 SV=1 CANONICAL=Q3T0W9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 13, "end_pos": 13, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W9", "url": "https://www.uniprot.org/uniprotkb/Q3T0W9" } ], "site_lbl": "Ser13" }, { "start_pos": 164, "end_pos": 164, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W9", "url": "https://www.uniprot.org/uniprotkb/Q3T0W9" } ], "site_lbl": "Ser164" }, { "start_pos": 187, "end_pos": 187, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3T0W9", "url": "https://www.uniprot.org/uniprotkb/Q3T0W9" } ], "site_lbl": "Thr187" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510615", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510615", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LN94-1", "protein_name": "Ribosomal protein L19", "gene_name": "Rpl19", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLIKDGLIIRKPVTVHSRARCRKNTLARRKGRHMGIGKRKGTANARMPEKVTWMRRMRILRRLLRRYRESKKIDRHMYHSLYLKVKGNVFKNKRILMEHIHKLKADKARKKLLADQAEARRSKTKEARKRREERLQAKKEEIIKTLSKEEETKK", "length": 196 }, "evidence": [ { "id": "Q3T0W9", "url": "https://omabrowser.org/oma/group/Q3T0W9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P0CX82-1", "protein_name": "Large ribosomal subunit protein eL19A", "gene_name": "RPL19A", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MANLRTQKRLAASVVGVGKRKVWLDPNETSEIAQANSRNAIRKLVKNGTIVKKAVTVHSKSRTRAHAQSKREGRHSGYGKRKGTREARLPSQVVWIRRLRVLRRLLAKYRDAGKIDKHLYHVLYKESKGNAFKHKRALVEHIIQAKADAQREKALNEEAEARRLKNRAARDRRAQRVAEKRDALLKEDA", "length": 189 }, "evidence": [ { "id": "Q3T0W9", "url": "https://omabrowser.org/oma/group/Q3T0W9/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P0CX83-1", "protein_name": "Large ribosomal subunit protein eL19", "gene_name": "RPL19B", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MANLRTQKRLAASVVGVGKRKVWLDPNETSEIAQANSRNAIRKLVKNGTIVKKAVTVHSKSRTRAHAQSKREGRHSGYGKRKGTREARLPSQVVWIRRLRVLRRLLAKYRDAGKIDKHLYHVLYKESKGNAFKHKRALVEHIIQAKADAQREKALNEEAEARRLKNRAARDRRAQRVAEKRDALLKEDA", "length": 189 }, "evidence": [ { "id": "Q3T0W9", "url": "https://omabrowser.org/oma/group/Q3T0W9/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P14329-1", 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"url": "https://omabrowser.org/oma/group/Q3T0W9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P84098-1", "protein_name": "Large ribosomal subunit protein eL19", "gene_name": "RPL19", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLIKDGLIIRKPVTVHSRARCRKNTLARRKGRHMGIGKRKGTANARMPEKVTWMRRMRILRRLLRRYRESKKIDRHMYHSLYLKVKGNVFKNKRILMEHIHKLKADKARKKLLADQAEARRSKTKEARKRREERLQAKKEEIIKTLSKEEETKK", "length": 196 }, "evidence": [ { "id": "Q3T0W9", "url": "https://omabrowser.org/oma/group/Q3T0W9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P84099-1", "protein_name": "Large ribosomal subunit protein eL19", "gene_name": "Rpl19", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLIKDGLIIRKPVTVHSRARCRKNTLARRKGRHMGIGKRKGTANARMPEKVTWMRRMRILRRLLRRYRESKKIDRHMYHSLYLKVKGNVFKNKRILMEHIHKLKADKARKKLLADQAEARRSKTKEARKRREERLQAKKEEIIKTLSKEEETKK", "length": 196 }, "evidence": [ { "id": "Q3T0W9", "url": "https://omabrowser.org/oma/group/Q3T0W9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P84100-1", "protein_name": "Large ribosomal subunit protein eL19", "gene_name": "Rpl19", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLIKDGLIIRKPVTVHSRARCRKNTLARRKGRHMGIGKRKGTANARMPEKVTWMRRMRILRRLLRRYRESKKIDRHMYHSLYLKVKGNVFKNKRILMEHIHKLKADKARKKLLADQAEARRSKTKEARKRREERLQAKKEEIIKTLSKEEETKK", "length": 196 }, "evidence": [ { "id": "Q3T0W9", "url": "https://omabrowser.org/oma/group/Q3T0W9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular 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(RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "P0CX51-1", "protein_name": "Small ribosomal subunit protein uS9A", "gene_name": "RPS16A", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSAVPSVQTFGKKKSATAVAHVKAGKGLIKVNGSPITLVEPEILRFKVYEPLLLVGLDKFSNIDIRVRVTGGGHVSQVYAIRQAIAKGLVAYHQKYVDEQSKNELKKAFTSYDRTLLIADSRRPEPKKFGGKGARSRFQKSYR", "length": 143 }, "evidence": [ { "id": "Q3T0X6", "url": "https://omabrowser.org/oma/group/Q3T0X6/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P0CX52-1", "protein_name": "Small ribosomal subunit protein uS9B", "gene_name": "RPS16B", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSAVPSVQTFGKKKSATAVAHVKAGKGLIKVNGSPITLVEPEILRFKVYEPLLLVGLDKFSNIDIRVRVTGGGHVSQVYAIRQAIAKGLVAYHQKYVDEQSKNELKKAFTSYDRTLLIADSRRPEPKKFGGKGARSRFQKSYR", "length": 143 }, "evidence": [ 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"count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0X7-1", "uniprot_ac": "Q3T0X7", "uniprot_id": "NSE1_BOVIN", "mass": { "chemical_mass": 30691.0, "monoisotopic_mass": 30691.0 }, "refseq": { "ac": "NP_001030483", "name": "non-structural maintenance of chromosomes element 1 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030483" }, "gene_names": [ { "name": "NSMCE1", "type": "recommended", "evidence": [ { "id": "Q3T0X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0X7" } ] }, { "name": "NSMCE1", "type": "synonym", "evidence": [ { "id": "NP_001030483", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030483" } ] } ], "protein_names": [ { "name": "Non-structural maintenance of chromosomes element 1 homolog", "type": "recommended", "evidence": [ { "id": "Q3T0X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0X7/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.27", "type": "synonym", "evidence": [ { "id": "Q3T0X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0X7/entry#names_and_taxonomy" } ] }, { "name": "Non-SMC element 1 homolog", "type": "synonym", "evidence": [ { "id": "Q3T0X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0X7/entry#names_and_taxonomy" } ] }, { "name": "non-SMC element 1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001030483", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030483" } ] }, { "name": "non-structural maintenance of chromosomes element 1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001030483", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030483" } ] } ], "function": [ { "annotation": "RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0X7", "url": "https://www.uniprot.org/uniprotkb/Q3T0X7#function" }, { "database": "UniProtKB", "id": "Q8WV22", "url": "https://www.uniprot.org/uniprotkb/Q8WV22#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0X7", "url": "https://www.uniprot.org/uniprotkb/Q3T0X7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NSMCE1", "url": "https://www.uniprot.org/uniprotkb/Q3T0X7", "locus": { "chromosome": "25", "start_pos": 24801767, "end_pos": 24840411, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002176", "url": "https://www.ensembl.org/id/ENSBTAG00000002176" } ] } } ], "crossref": [ { "id": "Q3T0X7", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0X7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd16493", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16493", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534249", "url": "https://www.ncbi.nlm.nih.gov/gene/534249", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011513", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011513", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046349", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046349", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534249", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534249", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T0X7", "url": "https://www.orthodb.org/?gene=Q3T0X7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20973", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20973", "database": "PANTHER", "categories": [ "Protein 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"publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T0X9-1", "uniprot_ac": "Q3T0X9", "uniprot_id": "DPOD4_BOVIN", "mass": { "chemical_mass": 12342.0, "monoisotopic_mass": 12342.0 }, "refseq": { "ac": "NP_001069949", "name": "DNA polymerase delta subunit 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069949" }, "gene_names": [ { "name": "POLD4", "type": "recommended", "evidence": [ { "id": "Q3T0X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0X9" } ] }, { "name": "POLD4", "type": "synonym", "evidence": [ { "id": "NP_001069949", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069949" } ] } ], "protein_names": [ { "name": "DNA polymerase delta subunit 4", "type": "recommended", "evidence": [ { "id": "Q3T0X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0X9/entry#names_and_taxonomy" } ] }, { "name": "DNA polymerase delta subunit 4", "type": "synonym", "evidence": [ { "id": "NP_001069949", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069949" } ] }, { "name": "DNA polymerase delta subunit p12", "type": "synonym", "evidence": [ { "id": "NP_001069949", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069949" }, { "id": "Q3T0X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0X9/entry#names_and_taxonomy" } ] }, { "name": "DNA-directed DNA polymerase delta 4", "type": "synonym", "evidence": [ { "id": "NP_001069949", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069949" } ] }, { "name": "polymerase (DNA-directed), delta 4, accessory subunit", "type": "synonym", "evidence": [ { "id": "NP_001069949", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069949" } ] } ], "function": [ { "annotation": "As a component of the tetrameric DNA polymerase delta 4 complex (Pol-delta4), plays a role in high fidelity genome replication and repair. 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Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival.", "evidence": [ { "database": "UniProtKB", "id": "Q3T0X9", "url": "https://www.uniprot.org/uniprotkb/Q3T0X9#function" }, { "database": "UniProtKB", "id": "Q9HCU8", "url": "https://www.uniprot.org/uniprotkb/Q9HCU8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T0X9", "url": "https://www.uniprot.org/uniprotkb/Q3T0X9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "POLD4", "url": "https://www.uniprot.org/uniprotkb/Q3T0X9", "locus": { "chromosome": "29", "start_pos": 45254013, "end_pos": 45256019, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017951", "url": "https://www.ensembl.org/id/ENSBTAG00000017951" } ] } } ], "crossref": [ { "id": "Q3T0X9", "url": "https://alphafold.ebi.ac.uk/entry/Q3T0X9", "database": "AlphaFoldDB", "categories": [] }, { "id": "617899", "url": "https://www.ncbi.nlm.nih.gov/gene/617899", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q3T0X9", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q3T0X9*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR007218", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007218", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617899", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617899", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T0X9", "url": "https://www.orthodb.org/?gene=Q3T0X9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14303", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14303", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14303:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14303:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04081", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04081", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069949", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0X9", "url": "https://www.uniprot.org/uniprotkb/Q3T0X9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0X9-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0X9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRKRLITDSYPVVKRREGSAGHSKGELAPDLGEEPLPLSVDEEELELLRQFDLAWQYGPCTGITRLQRWHRAEQMGLKPPPEVHQVLQSHPGDPRFQCSLWHFYPL", "length": 107, "header": "sp|Q3T0X9-1|DPOD4_BOVIN Isoform 1 of DNA polymerase delta subunit 4 OS=Bos taurus OX=9913 GN=POLD4 PE=1 SV=1 CANONICAL=Q3T0X9-1" }, "isoforms": [ { "isoform_ac": "Q3T0X9-1", "url": "https://www.uniprot.org/uniprotkb/Q3T0X9/entry#Q3T0X9-1", "sequence": { "sequence": "MGRKRLITDSYPVVKRREGSAGHSKGELAPDLGEEPLPLSVDEEELELLRQFDLAWQYGPCTGITRLQRWHRAEQMGLKPPPEVHQVLQSHPGDPRFQCSLWHFYPL", "length": 107, "header": "sp|Q3T0X9-1|DPOD4_BOVIN Isoform 1 of DNA polymerase delta subunit 4 OS=Bos taurus OX=9913 GN=POLD4 PE=1 SV=1 CANONICAL=Q3T0X9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Identification of a fourth subunit of mammalian DNA polymerase delta.", "journal": "J. 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Stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis. Plays a role in the maintenance of intestinal homeostasis and clearance of enteric pathogens. Upon NOD2 stimulation, ubiquitinates the ER stress sensor activating transcription factor 6/ATF6 and promotes the unfolded protein response UPR. Participates in basal level of autophagy maintenance by regulating the ubiquitination of EPHB2. Upon stimulation by ligand EFNB1, ubiquitinates EPHB2 and further recruits MAP1LC3B for autophagy induction. 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"database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3T0Y9", "url": "https://www.orthodb.org/?gene=Q3T0Y9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22791", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22791", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22791:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22791:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14634", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14634", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030388", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T0Y9", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T0Y9-1", "url": 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OX=9913 GN=RNF186 PE=2 SV=1 CANONICAL=Q3T0Y9-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 33, "start_aa": "Thr", "end_pos": 33, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr33", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:515529", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515529", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "protein localization to mitochondrion", "id": "GO:0070585", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070585", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Y9", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y9" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Y9", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y9" } ], "pmid": "" }, { "name": "protein autoubiquitination", "id": "GO:0051865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051865", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Y9", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y9" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "id": "GO:0070059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070059", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Y9", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y9" } ], "pmid": "" }, { "name": "protein K63-linked ubiquitination", "id": "GO:0070534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070534", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Y9", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y9" } ], "pmid": "" }, { "name": "protein K29-linked ubiquitination", "id": "GO:0035519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035519", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Y9", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Y9", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y9" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Y9", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y9" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Y9", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3T0Y9", "url": "https://www.uniprot.org/uniprotkb/Q3T0Y9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3T0Y9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 226, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3T0Y9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3T0Y9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 33 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T104-1", "uniprot_ac": "Q3T104", "uniprot_id": "SC61G_BOVIN", "mass": { "chemical_mass": 7741.0, "monoisotopic_mass": 7741.0 }, "refseq": { "ac": "NP_001035676", "name": "protein transport protein Sec61 subunit gamma", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035676" }, "gene_names": [ { "name": "SEC61G", "type": "recommended", "evidence": [ { "id": "Q3T104", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T104" } ] }, { "name": "SEC61G", "type": "synonym", "evidence": [ { "id": "NP_001035676", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035676" } ] } ], "protein_names": [ { "name": "Protein transport protein Sec61 subunit gamma", "type": "recommended", "evidence": [ { "id": "Q3T104", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T104/entry#names_and_taxonomy" } ] }, { "name": "SEC61 translocon gamma subunit", "type": "synonym", "evidence": [ { "id": "NP_001035676", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035676" } ] }, { "name": "Sec61 gamma subunit", "type": "synonym", "evidence": [ { "id": "NP_001035676", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035676" } ] }, { "name": "protein transport protein Sec61 subunit gamma", "type": "synonym", "evidence": [ { "id": "NP_001035676", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035676" } ] } ], "function": [ { "annotation": "Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (By similarity). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3T104", "url": "https://www.uniprot.org/uniprotkb/Q3T104#function" }, { "database": "UniProtKB", "id": "P60058", "url": "https://www.uniprot.org/uniprotkb/P60058#function" }, { "database": "UniProtKB", "id": "P60059", "url": "https://www.uniprot.org/uniprotkb/P60059#function" }, { "database": "UniProtKB", "id": "P61619", "url": "https://www.uniprot.org/uniprotkb/P61619#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T104", "url": "https://www.uniprot.org/uniprotkb/Q3T104" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SEC61G", "url": "https://www.uniprot.org/uniprotkb/Q3T104", "locus": { "chromosome": "22", "start_pos": 1466666, "end_pos": 1459780, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014971", "url": "https://www.ensembl.org/id/ENSBTAG00000014971" } ] } } ], "crossref": [ { "id": "Q3T104", "url": "https://alphafold.ebi.ac.uk/entry/Q3T104", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014971", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014971", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615778", "url": "https://www.ncbi.nlm.nih.gov/gene/615778", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001901", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001901", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008158", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008158", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023391", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023391", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615778", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615778", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KPDQKEY", "url": "https://omabrowser.org/oma/group/KPDQKEY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T104", "url": "https://www.orthodb.org/?gene=Q3T104", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12309", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12309", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00584", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00584", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9609523", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9609523", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001035676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035676", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T104", "url": "https://www.uniprot.org/uniprotkb/Q3T104", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T104-1", "url": "https://www.uniprot.org/uniprotkb/Q3T104-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG", "length": 68, "header": "sp|Q3T104-1|SC61G_BOVIN Isoform 1 of Protein transport protein Sec61 subunit gamma OS=Bos taurus OX=9913 GN=SEC61G PE=3 SV=1 CANONICAL=Q3T104-1" }, "isoforms": [ { "isoform_ac": "Q3T104-1", "url": "https://www.uniprot.org/uniprotkb/Q3T104/entry#Q3T104-1", "sequence": { "sequence": "MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG", "length": 68, "header": "sp|Q3T104-1|SC61G_BOVIN Isoform 1 of Protein transport protein Sec61 subunit gamma OS=Bos taurus OX=9913 GN=SEC61G PE=3 SV=1 CANONICAL=Q3T104-1" }, "locus": { "chromosome": "22", "start_pos": 1466510, "end_pos": 1461287, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019929.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019929.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019929.3", "url": "https://www.ensembl.org/id/ENSBTAP00000019929.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 18, "end_pos": 18, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T104", "url": "https://www.uniprot.org/uniprotkb/Q3T104" } ], "site_lbl": "Ser18" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615778", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615778", "resource": "KEGG Pathway" }, { "id": "R-BTA-9609523", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9609523", "resource": "Reactome", "description": "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8J8XD56-1", "protein_name": "Protein transport protein Sec61 subunit gamma", "gene_name": "Sec61gl4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "VGGLLTGFRFRWAQFSPRLRVSALSNRHPTNMDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG", "length": 99 }, "evidence": [ { "id": "Q3T104", "url": "https://omabrowser.org/oma/group/Q3T104/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0XUS1-1", "protein_name": "Protein transport protein Sec61 subunit gamma", "gene_name": "SEC61G", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIV", "length": 66 }, "evidence": [ { "id": "Q3T104", "url": "https://omabrowser.org/oma/group/Q3T104/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7HB11-1", "protein_name": "Protein transport protein Sec61 subunit gamma isoform X2", "gene_name": "Sec61g", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSGPGNDGNEGWGEGATVLTGCRDEGEGAIDEPGGHELRPGSCRIRTSPLGWIADGQVDRDQIQAQDLPVWPQVEVSSQTCLEELSTMDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKGLGTNSVIKCC", "length": 129 }, "evidence": [ { "id": "Q3T104", "url": "https://omabrowser.org/oma/group/Q3T104/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F2Z4R1-1", "protein_name": "Protein transport protein Sec61 subunit gamma", "gene_name": "sec61g", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG", "length": 68 }, "evidence": [ { "id": "Q3T104", "url": "https://omabrowser.org/oma/group/Q3T104/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P0DI74-1", "protein_name": "Protein transport protein Sec61 subunit gamma-1", "gene_name": "SEC61G1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDAIDSVVDPLRDFAKDSIRLVKRCHKPDRKEFTKVAVRTAIGFVVMGFVGFFVKLIFIPINNIIVGAT", "length": 69 }, "evidence": [ { "id": "Q3T104", "url": "https://omabrowser.org/oma/group/Q3T104/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P0DI75-1", "protein_name": "Protein transport protein Sec61 subunit gamma-2", "gene_name": "SEC61G2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDAIDSVVDPLRDFAKDSIRLVKRCHKPDRKEFTKVAVRTAIGFVVMGFVGFFVKLIFIPINNIIVGAT", "length": 69 }, "evidence": [ { "id": "Q3T104", "url": "https://omabrowser.org/oma/group/Q3T104/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P35179-1", "protein_name": "Protein transport protein SSS1", "gene_name": "SSS1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MARASEKGEEKKQSNNQVEKLVEAPVEFVREGTQFLAKCKKPDLKEYTKIVKAVGIGFIAVGIIGYAIKLIHIPIRYVIV", "length": 80 }, "evidence": [ { "id": "Q3T104", "url": "https://omabrowser.org/oma/group/Q3T104/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P60059-1", "protein_name": "Protein transport protein Sec61 subunit gamma", "gene_name": "SEC61G", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG", "length": 68 }, "evidence": [ { "id": "Q3T104", "url": "https://omabrowser.org/oma/group/Q3T104/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P60060-1", "protein_name": "Protein transport protein Sec61 subunit gamma", "gene_name": "Sec61g", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG", "length": 68 }, "evidence": [ { "id": "Q3T104", "url": "https://omabrowser.org/oma/group/Q3T104/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54JV6-1", "protein_name": "Protein transport protein Sec61 subunit gamma", "gene_name": "sec61g", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDILEETAAPLKDFAKNSIRLFKKCTKPDAQEFQKIALATLIGFAIMGFIGFFVKLIHIPINNILVGGV", "length": 69 }, "evidence": [ { "id": "Q3T104", "url": "https://omabrowser.org/oma/group/Q3T104/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9V668-1", "protein_name": "Protein transport protein Sec61 gamma-1 subunit", "gene_name": "SEC61G1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDKVVKFAEPGRAFAKDSIRLVKRCTKPDRKEFQKIAIATAVGFAIMGFIGFFVKLIHIPINNIIVGS", "length": 68 }, "evidence": [ { "id": "Q3T104", "url": "https://omabrowser.org/oma/group/Q3T104/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "Q3T104", "url": "https://www.uniprot.org/uniprotkb/Q3T104" } ], "pmid": "" }, { "name": "protein transmembrane transporter activity", "id": "GO:0008320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008320", "evidence": [ { "database": "UniProtKB", "id": "Q3T104", "url": "https://www.uniprot.org/uniprotkb/Q3T104" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, 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"o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T108-1", "uniprot_ac": "Q3T108", "uniprot_id": "PSB4_BOVIN", "mass": { "chemical_mass": 29031.0, "monoisotopic_mass": 29031.0 }, "refseq": { "ac": "NP_001029438", "name": "proteasome subunit beta type-4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029438" }, "gene_names": [ { "name": "PSMB4", "type": "recommended", "evidence": [ { "id": "Q3T108", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T108" } ] }, { "name": "PSMB4", "type": "synonym", "evidence": [ { "id": "NP_001029438", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029438" } ] } ], "protein_names": [ { "name": "Proteasome subunit beta type-4", "type": "recommended", "evidence": [ { "id": "Q3T108", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T108/entry#names_and_taxonomy" } ] }, { "name": "proteasome (prosome, macropain) subunit, beta type, 4", "type": "synonym", "evidence": [ { "id": "NP_001029438", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029438" } ] }, { "name": "proteasome subunit beta 4", "type": "synonym", "evidence": [ { "id": "NP_001029438", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029438" } ] }, { "name": "proteasome subunit beta type-4", "type": "synonym", "evidence": [ { "id": "NP_001029438", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029438" } ] } ], "function": [ { "annotation": "Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.", "evidence": [ { "database": "UniProtKB", "id": "Q3T108", "url": "https://www.uniprot.org/uniprotkb/Q3T108#function" }, { "database": "UniProtKB", "id": "P28070", "url": "https://www.uniprot.org/uniprotkb/P28070#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T108", "url": "https://www.uniprot.org/uniprotkb/Q3T108" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSMB4", "url": "https://www.uniprot.org/uniprotkb/Q3T108", "locus": { "chromosome": "3", "start_pos": 19371028, "end_pos": 19373387, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021288", "url": "https://www.ensembl.org/id/ENSBTAG00000021288" } ] } } ], "crossref": [ { 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{ "id": "Q3T122", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T122/entry#names_and_taxonomy" } ] }, { "name": "eIF-3-zeta", "type": "synonym", "evidence": [ { "id": "Q3T122", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T122/entry#names_and_taxonomy" } ] }, { "name": "eIF3d", "type": "synonym", "evidence": [ { "id": "Q3T122", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T122/entry#names_and_taxonomy" } ] }, { "name": "eukaryotic translation initiation factor 3 subunit D", "type": "synonym", "evidence": [ { "id": "NP_001029656", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029656" } ] }, { "name": "eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa", "type": "synonym", "evidence": [ { "id": "NP_001029656", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029656" } ] } ], "function": [ { "annotation": "mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.", "evidence": [ { "database": "UniProtKB", "id": "Q3T122", "url": "https://www.uniprot.org/uniprotkb/Q3T122#function" }, { "database": "HAMAP", "id": "MF_03003", "url": "https://hamap.expasy.org/signature/MF_03003" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T122", "url": "https://www.uniprot.org/uniprotkb/Q3T122" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF3D", "url": "https://www.uniprot.org/uniprotkb/Q3T122", "locus": { "chromosome": "5", "start_pos": 74925199, "end_pos": 74939376, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001988", "url": "https://www.ensembl.org/id/ENSBTAG00000001988" } ] } } ], "crossref": [ { "id": "Q3T122", "url": "https://alphafold.ebi.ac.uk/entry/Q3T122", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001988", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001988", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515226", "url": "https://www.ncbi.nlm.nih.gov/gene/515226", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515226", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515226", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FMDKRDN", "url": "https://omabrowser.org/oma/group/FMDKRDN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T122", "url": "https://www.orthodb.org/?gene=Q3T122", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12399", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12399", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12399:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12399:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05091", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05091", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029656", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T122", "url": "https://www.uniprot.org/uniprotkb/Q3T122", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T122-1", "url": "https://www.uniprot.org/uniprotkb/Q3T122-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDETSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMLQFNLQTLPKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQQCLRMGKERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDDEEEEEEEEEEEEEEA", "length": 548, "header": "sp|Q3T122-1|EIF3D_BOVIN Isoform 1 of Eukaryotic translation initiation factor 3 subunit D OS=Bos taurus OX=9913 GN=EIF3D PE=2 SV=1 CANONICAL=Q3T122-1" }, "isoforms": [ { "isoform_ac": "Q3T122-1", "url": "https://www.uniprot.org/uniprotkb/Q3T122/entry#Q3T122-1", "sequence": { "sequence": "MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDETSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMLQFNLQTLPKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQQCLRMGKERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDDEEEEEEEEEEEEEEA", "length": 548, "header": "sp|Q3T122-1|EIF3D_BOVIN Isoform 1 of Eukaryotic translation initiation factor 3 subunit D OS=Bos taurus OX=9913 GN=EIF3D PE=2 SV=1 CANONICAL=Q3T122-1" }, "locus": { "chromosome": "5", "start_pos": 74936932, "end_pos": 74925333, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037985.4", "url": "https://www.ensembl.org/id/ENSBTAT00000037985.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037804.2", "url": "https://www.ensembl.org/id/ENSBTAP00000037804.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 161, "end_pos": 161, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T122", "url": "https://www.uniprot.org/uniprotkb/Q3T122" } ], "site_lbl": "Ser161" }, { "start_pos": 528, "end_pos": 528, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T122", "url": "https://www.uniprot.org/uniprotkb/Q3T122" } ], "site_lbl": "Ser528" }, { "start_pos": 529, "end_pos": 529, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3T122", "url": "https://www.uniprot.org/uniprotkb/Q3T122" } ], "site_lbl": "Ser529" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515226", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515226", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-72649", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "resource": "Reactome", "description": "Translation initiation complex formation" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "resource": "Reactome", "description": "Formation of the ternary complex, and subsequently, the 43S complex" }, { "id": "R-BTA-72702", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "resource": "Reactome", "description": "Ribosomal scanning and start codon recognition" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061IEG5-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit D", "gene_name": "Eif3d", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDETSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMVQFNLQTLPKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQQCLRMGRERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGATGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSEEDEEDEEEEEEEEEEEET", "length": 548 }, "evidence": [ { "id": "Q3T122", "url": "https://omabrowser.org/oma/group/Q3T122/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A4X1U4W6-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit D", "gene_name": "EIF3D", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDETSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMLQFNLQTLPKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQQCLRMGKERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDDEEEEEEEEEEEEEET", "length": 548 }, "evidence": [ { "id": "Q3T122", "url": "https://omabrowser.org/oma/group/Q3T122/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1NCE1-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit D", "gene_name": "EIF3D", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAKFVTPVIQDNPSGWGPCAVPEQFKDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDETSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMLQFSMQTLPKSAKQKERDRLRLQKKFQKQFGVRQKWDQKSQQKPRDSSVEVRSDWEVKEEMDFPRLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRNEKLLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIIVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQEEGNSFNSPRNLAMEATYINHNFSQQCLRMGKEKYKFPNPNPFVEDDMDKNEVASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRYCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSARHVILGTQQFKPNEFASQINLSIENAWGILRCVIDICMKLDEGKYLILKDPNKQVIRIYSLPDGTFSSDEDEEDEEEEEEEEEEES", "length": 548 }, "evidence": [ { "id": "Q3T122", "url": "https://omabrowser.org/oma/group/Q3T122/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O15371-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit D", "gene_name": "EIF3D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDESSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMLQFNLQILPKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQQCLRMGKERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEEEEET", "length": 548 }, "evidence": [ { "id": "Q3T122", "url": "https://omabrowser.org/oma/group/Q3T122/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O70194-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit D", "gene_name": "Eif3d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDETSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMVQFNLQTLPKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQQCLRMGRERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSEEDEEDEEEEEEEEEEEET", "length": 548 }, "evidence": [ { "id": "Q3T122", "url": "https://omabrowser.org/oma/group/Q3T122/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6AYK8-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit D", "gene_name": "Eif3d", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDETSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMVQFNLQTLPKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQQCLRMGRERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSEEDEEDEEEEEEEEEEEET", "length": 548 }, "evidence": [ { "id": "Q3T122", "url": "https://omabrowser.org/oma/group/Q3T122/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6TH15-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit D", "gene_name": "eif3d", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAKFHAPVIQDNPSGWGPCAVPEKFKDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDEASFQLVDTAKTQKTAYQRNRMRFAQRNLRRDKDRRTLTQFNMQTLPKSAKQKERDRMRLQKKFQKQFGVRQKWDQKSQAQLKPRDSSVEVRSDWEVKEEMDFPRLMKMRYMDVADPLDIECCGALEHYDKAFDRITTRNEKPLKSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMCCTRSVNSWDIIVQRVGNKLFFDKRDNSDFDLLTVSETANEPPQDEGSSLNSPRNLAMEATYINHNFSQQCLRMGGERYKFPNPNPFVEEDTEKSEVASVAYRYRRWKLGEDIDLIVRCEHDGVMTGANGEVSFINVKTLNEWDSRYCNGVDWRQKLDSQRGAVLATELKNNSYKLARWTCCAILAGSEYLKLGYVSRYHVKDSSRHVVLGTQQFKPNEFASQINLSMENAWGILRCVIDICRKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEDDEDEEDEEEDEDN", "length": 552 }, "evidence": [ { "id": "Q3T122", "url": "https://omabrowser.org/oma/group/Q3T122/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9VCK0-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit D-1", "gene_name": "eIF3d1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSETINTAAQFPSFEKPTVQFNEKGWGPCELPDTFKDVPYQPFSKNDRLGKICDWTNTSNNDKKYQNKYASSFGTGIQYSYYHEEDETTFHLVDTARVQKPPHQRGRFRNMRNSRSGRGRNARGGLNTHGMTTLSGKNVKARDPRHGRGMGKKFGHRGPPPKMRESSVAVRADWASIEEMDFPRLIKLSLPNIKEGVDIVTCGTLEYYDKTYDRINVKNEKPLQKIDRIVHTVTTTDDPVIRRLSKTVGNVFATDAILATIMCSTRSNYSWDIVIEKVGDKVFMDKRDHTEFDLLTVNESSVEPPTDDDSSCNSPRNLAIEATFINHNFSQQVLKTGDQEPKYKFEESNPFISEDEDIQVASVGYRYKKWELGSDIVLVARCEHDGVLQTPSGEPQFMTIKALNEWDSKLANGVEWRQKLDTQRGAVLANELRNNACKLAKWTVQAVLAGSDQLKLGYVSRINPRDHSRHVILGTQQFKPHEFATQINLSMDNAWGILRCIIDLVMKQKDGKYLIMKDPNKPIIRLYDIPDNTFDSDDSDDGEGDDEGFQQVYNYAHNKI", "length": 560 }, "evidence": [ { "id": "Q3T122", "url": "https://omabrowser.org/oma/group/Q3T122/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "IRES-dependent viral translational initiation", "id": "GO:0075522", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0075522", "evidence": [ { "database": "UniProtKB", "id": "Q3T122", "url": "https://www.uniprot.org/uniprotkb/Q3T122" } ], "pmid": "" }, { "name": "translational initiation", "id": "GO:0006413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006413", "evidence": [ { "database": "UniProtKB", "id": "Q3T122", "url": "https://www.uniprot.org/uniprotkb/Q3T122" } ], "pmid": "" }, { "name": "formation of cytoplasmic translation initiation complex", "id": "GO:0001732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001732", "evidence": [ { "database": "UniProtKB", "id": "Q3T122", "url": "https://www.uniprot.org/uniprotkb/Q3T122" } ], "pmid": "" }, { "name": "viral translational termination-reinitiation", "id": "GO:0075525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0075525", "evidence": [ { "database": "UniProtKB", "id": "Q3T122", "url": "https://www.uniprot.org/uniprotkb/Q3T122" } ], "pmid": "" }, { "name": "cap-dependent translational initiation", "id": "GO:0002191", "url": 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The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.", "evidence": [ { "database": "UniProtKB", "id": "Q3T148", "url": "https://www.uniprot.org/uniprotkb/Q3T148#function" }, { "database": "HAMAP", "id": "MF_03012", "url": "https://hamap.expasy.org/signature/MF_03012" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T148", "url": "https://www.uniprot.org/uniprotkb/Q3T148" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF3M", "url": "https://www.uniprot.org/uniprotkb/Q3T148", "locus": { "chromosome": "15", "start_pos": 63317185, 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}, { "name": "formation of cytoplasmic translation initiation complex", "id": "GO:0001732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001732", "evidence": [ { "database": "UniProtKB", "id": "Q3T148", "url": "https://www.uniprot.org/uniprotkb/Q3T148" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3T148", "url": "https://www.uniprot.org/uniprotkb/Q3T148" } ], "pmid": "" }, { "name": "eukaryotic 43S preinitiation complex", "id": "GO:0016282", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016282", "evidence": [ { "database": "UniProtKB", "id": "Q3T148", "url": "https://www.uniprot.org/uniprotkb/Q3T148" } ], "pmid": "" }, { "name": "eukaryotic 48S preinitiation complex", "id": "GO:0033290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033290", "evidence": [ { "database": "UniProtKB", "id": "Q3T148", "url": "https://www.uniprot.org/uniprotkb/Q3T148" } ], "pmid": "" }, { "name": "eukaryotic translation initiation factor 3 complex, eIF3m", "id": "GO:0071541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071541", "evidence": [ { "database": "UniProtKB", "id": "Q3T148", "url": "https://www.uniprot.org/uniprotkb/Q3T148" } ], "pmid": "" }, { "name": "eukaryotic translation initiation factor 3 complex", "id": "GO:0005852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005852", "evidence": [ { "database": "UniProtKB", "id": "Q3T148", "url": "https://www.uniprot.org/uniprotkb/Q3T148" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "Q3T148", "url": "https://www.uniprot.org/uniprotkb/Q3T148" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 155, "end_pos": 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TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. 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Transcription Initiation And Promoter Clearance" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JZ70-1", "protein_name": "Transcription initiation factor TFIID subunit 12", "gene_name": "Taf12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAASPYSGLTAVADVIKDLDTQIALIGLGPHSSKKKQDLDKLYELKCKAGQIMNQFGPSALINLSSFSSIKPEPASTPPQGSMANSTTVGKMPGTPGTGGRLSPENNQVLTKKKLQDLVREVDPNEQLDEDVEEMLLQIADDFIESVVTAACQLARHRKSSTLEVKDVQLHLERQWNMWIPGFGSEEIRPYKKACTTEAHKQRMALIRKTTKK", "length": 213 }, "evidence": [ { "id": "Q3T174", "url": "https://omabrowser.org/oma/group/Q3T174/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0YS19-1", "protein_name": "Transcription initiation factor TFIID subunit 12", "gene_name": "TAF12", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": 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{ "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3T197-1", "uniprot_ac": "Q3T197", "uniprot_id": "STEEP_BOVIN", "mass": { "chemical_mass": 25592.0, "monoisotopic_mass": 25592.0 }, "refseq": { "ac": "NP_001029391", "name": "STING ER exit protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029391" }, "gene_names": [ { "name": "STEEP1", "type": "recommended", "evidence": [ { "id": "Q3T197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T197" } ] }, { "name": "CXHXorf56", "type": "synonym", "evidence": [ { "id": "NP_001029391", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029391" } ] }, { "name": "CXorf56", "type": "synonym", "evidence": [ { "id": "NP_001029391", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029391" } ] }, { "name": "STEEP1", "type": "synonym", "evidence": [ { "id": "NP_001029391", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029391" } ] }, { "name": "STEEP", "type": "synonym", "evidence": [ { "id": "NP_001029391", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029391" } ] } ], "protein_names": [ { "name": "STING ER exit protein", "type": "recommended", "evidence": [ { "id": "Q3T197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T197/entry#names_and_taxonomy" } ] }, { "name": "STEEP", "type": "synonym", "evidence": [ { "id": "Q3T197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T197/entry#names_and_taxonomy" } ] }, { "name": "STING ER exit protein", "type": "synonym", "evidence": [ { "id": "NP_001029391", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029391" } ] }, { "name": "UPF0428 protein CXorf56 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029391", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029391" } ] }, { "name": "chromosome X CXorf56 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029391", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029391" } ] } ], "function": [ { "annotation": "Molecular adapter that stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport. Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers.", "evidence": [ { "database": "UniProtKB", "id": "Q3T197", "url": "https://www.uniprot.org/uniprotkb/Q3T197#function" }, { "database": "UniProtKB", "id": "Q9H5V9", "url": "https://www.uniprot.org/uniprotkb/Q9H5V9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3T197", "url": "https://www.uniprot.org/uniprotkb/Q3T197" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STEEP1", "url": "https://www.uniprot.org/uniprotkb/Q3T197", "locus": { "chromosome": "X", "start_pos": 3909615, "end_pos": 3921974, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047169", "url": "https://www.ensembl.org/id/ENSBTAG00000047169" } ] } } ], "crossref": [ { "id": "Q3T197", "url": "https://alphafold.ebi.ac.uk/entry/Q3T197", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047169", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047169", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504687", "url": "https://www.ncbi.nlm.nih.gov/gene/504687", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029704", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029704", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504687", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504687", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HVTFVMF", "url": "https://omabrowser.org/oma/group/HVTFVMF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3T197", "url": "https://www.orthodb.org/?gene=Q3T197", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46355", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46355", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46355:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46355:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF25809", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25809", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029391", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3T197", "url": "https://www.uniprot.org/uniprotkb/Q3T197", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3T197-1", "url": "https://www.uniprot.org/uniprotkb/Q3T197-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPKVVSRSVVCSDTRDREEYDDGEKPLHVYYCLCGQMVLVLDCQLEKLPMRPRDRSRVIDGAKHAHKFCNTEDEETIYLRRPEGIERQYRKKCAKCGLPLFYQSQPKNAPVTFIVDGAVVKFGQGFGKTNIYTQKQEPPKKVMMTKRTKDMGKFSSVTVSTIDEEEEEIEAREVADSYAQNAKVIEKQLERKGMSKRRLQELAELEAKKAKMKGTLIDNQFK", "length": 222, "header": "sp|Q3T197-1|STEEP_BOVIN Isoform 1 of STING ER exit protein OS=Bos taurus OX=9913 GN=STEEP1 PE=2 SV=1 CANONICAL=Q3T197-1" }, "isoforms": [ { "isoform_ac": "Q3T197-1", "url": "https://www.uniprot.org/uniprotkb/Q3T197/entry#Q3T197-1", "sequence": { "sequence": "MPKVVSRSVVCSDTRDREEYDDGEKPLHVYYCLCGQMVLVLDCQLEKLPMRPRDRSRVIDGAKHAHKFCNTEDEETIYLRRPEGIERQYRKKCAKCGLPLFYQSQPKNAPVTFIVDGAVVKFGQGFGKTNIYTQKQEPPKKVMMTKRTKDMGKFSSVTVSTIDEEEEEIEAREVADSYAQNAKVIEKQLERKGMSKRRLQELAELEAKKAKMKGTLIDNQFK", "length": 222, "header": "sp|Q3T197-1|STEEP_BOVIN Isoform 1 of STING ER exit protein OS=Bos taurus OX=9913 GN=STEEP1 PE=2 SV=1 CANONICAL=Q3T197-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504687", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504687", "resource": "KEGG Pathway" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1W7J2-1", "protein_name": "STING ER exit protein", "gene_name": "STEEP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPKVVSRSVVCSDTRDREEYDDGEKPLHVYYCLCGQMVLVLDCQLEKLPMRPRDRSRVIDAAKHAHKFCNTEDEETMYLRRCGLPLFYQSQPKNAPVTFIVDGAVVKFGQGFGKTNIYTQKQEPPKKVMMTKRTKDMGKFSSVTVSTIDEEEEEIEAREVADSYAQNAKVIEKQLERKGMSKRRLQELAELEAKKAKMKGTLIDNQFK", "length": 208 }, "evidence": [ { "id": "Q3T197", "url": "https://omabrowser.org/oma/group/Q3T197/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "E1BYZ0-1", "protein_name": "STING ER exit protein", "gene_name": "STEEP1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPKVVSRSVVCSDTRDREEYDDGEKPLHVYYCLCGQMVLVLDCQLEKLPMRPRDRARVIDAAKHAHKFCNAEEEETVFLRRPEGIERQFRKKCGKCGLLLFYQHQQKNAPVTFIVDGAVVKFGQGFGKTNIYTQKQEPPKKVMMTKRTKDMGKFSSVTVSTIDEEEEEIEAREIADSYAQNAKVIEKQLERKGMSKRRLQELAELEAKKAKMKGTLIDNQFK", "length": 222 }, "evidence": [ { "id": "Q3T197", "url": "https://omabrowser.org/oma/group/Q3T197/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8VDP2-1", "protein_name": "STING ER exit protein", "gene_name": "Steep1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKVVSRSVVCSDTRDREEYDDGEKPLHVYYCLCGQMVLVLDCQLEKLPMRPRDRSRVIDAAKHAHKFCNTEDEETTYLRRPEGIERQYRKKCAKCGLPLFYQSQPKNAPVTFIVDGAVVKFGQGFGKTNIYTQKQEPPKKVMMTKRTKDMGKFSSVTVSTIDEEEEEIEAREVADSYAQNAKVIEKQLERKGMSKRRLQELAELEAKKAKMKGTLIDNQFK", "length": 222 }, "evidence": [ { "id": "Q3T197", "url": "https://omabrowser.org/oma/group/Q3T197/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H5V9-1", "protein_name": "STING ER exit protein", "gene_name": "STEEP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPKVVSRSVVCSDTRDREEYDDGEKPLHVYYCLCGQMVLVLDCQLEKLPMRPRDRSRVIDAAKHAHKFCNTEDEETMYLRRPEGIERQYRKKCAKCGLPLFYQSQPKNAPVTFIVDGAVVKFGQGFGKTNIYTQKQEPPKKVMMTKRTKDMGKFSSVTVSTIDEEEEEIEAREVADSYAQNAKVIEKQLERKGMSKRRLQELAELEAKKAKMKGTLIDNQFK", "length": 222 }, "evidence": [ { "id": "Q3T197", "url": "https://omabrowser.org/oma/group/Q3T197/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9V412-1", "protein_name": "STING ER exit protein", "gene_name": "Steep1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPKVVSRSIVCSDTKDQEEYNEEKPLNIYYCLCNKMALILDCTLEQLPLREVDNARVINANDHANKLTHNPTPRMVYIKRKSRGNGIEKQYRYKCRSCSLPLYYRHSPDSHVTFVMSNALIRNKGESPLTQLLNSEIKGSFKAPAAKPATSAGPDDSGIVDASGKKVVVTRHTKNMGKFSSVTVSTIDEEEDEIEAREIADSYANNARIIEKQLQRKGGKLSDVGIKTKTEDAPPPQKKQRGTLLER", "length": 247 }, "evidence": [ { "id": "Q3T197", "url": "https://omabrowser.org/oma/group/Q3T197/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum membrane organization", "id": "GO:0090158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090158", "evidence": [ { "database": "UniProtKB", "id": "Q3T197", "url": "https://www.uniprot.org/uniprotkb/Q3T197" } ], "pmid": "" }, { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "Q3T197", "url": "https://www.uniprot.org/uniprotkb/Q3T197" } ], "pmid": "" }, { "name": "protein exit from endoplasmic reticulum", "id": "GO:0032527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032527", "evidence": [ { "database": "UniProtKB", "id": "Q3T197", "url": "https://www.uniprot.org/uniprotkb/Q3T197" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3T197", "url": "https://www.uniprot.org/uniprotkb/Q3T197" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3T197", "url": "https://www.uniprot.org/uniprotkb/Q3T197" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3T197", "url": "https://www.uniprot.org/uniprotkb/Q3T197" } ], "pmid": "" }, { "name": "cell body", "id": "GO:0044297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044297", "evidence": [ { "database": "UniProtKB", "id": "Q3T197", "url": "https://www.uniprot.org/uniprotkb/Q3T197" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "Q3T197", "url": "https://www.uniprot.org/uniprotkb/Q3T197" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": 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"total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 8 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBA6-1", "uniprot_ac": "Q3ZBA6", "uniprot_id": "DJB11_BOVIN", "mass": { "chemical_mass": 40504.0, "monoisotopic_mass": 40504.0 }, "refseq": { "ac": "NP_001029440", "name": "dnaJ homolog subfamily B member 11 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029440" }, "gene_names": [ { "name": "DNAJB11", "type": "recommended", "evidence": [ { "id": "Q3ZBA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6" } ] }, { "name": "DNAJB11", "type": "synonym", "evidence": [ { "id": "NP_001029440", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029440" } ] } ], "protein_names": [ { "name": "DnaJ homolog subfamily B member 11", "type": "recommended", "evidence": [ { "id": "Q3ZBA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6/entry#names_and_taxonomy" } ] }, { "name": "DnaJ (Hsp40) homolog, subfamily B, member 11", "type": "synonym", "evidence": [ { "id": "NP_001029440", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029440" } ] }, { "name": "ER-associated DNAJ", "type": "synonym", "evidence": [ { "id": "Q3ZBA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6/entry#names_and_taxonomy" } ] }, { "name": "ER-associated Hsp40 co-chaperone", "type": "synonym", "evidence": [ { "id": "NP_001029440", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029440" }, { "id": "Q3ZBA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6/entry#names_and_taxonomy" } ] }, { "name": "ER-associated dnaJ protein 3", "type": "synonym", "evidence": [ { "id": "NP_001029440", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029440" } ] }, { "name": "ER-resident protein ERdj3", "type": "synonym", "evidence": [ { "id": "NP_001029440", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029440" }, { "id": "Q3ZBA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6/entry#names_and_taxonomy" } ] }, { "name": "ERdj3", "type": "synonym", "evidence": [ { "id": "NP_001029440", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029440" }, { "id": "Q3ZBA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6/entry#names_and_taxonomy" } ] }, { "name": "ERj3p", "type": "synonym", "evidence": [ { "id": "NP_001029440", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029440" }, { "id": "Q3ZBA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6/entry#names_and_taxonomy" } ] }, { "name": "Endoplasmic reticulum DNA J domain-containing protein 3", "type": "synonym", "evidence": [ { "id": "Q3ZBA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6/entry#names_and_taxonomy" } ] }, { "name": "dnaJ homolog subfamily B member 11 precursor", "type": "synonym", "evidence": [ { "id": "NP_001029440", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029440" } ] }, { "name": "dnaJ homolog subfamily B member 11", "type": "synonym", "evidence": [ { "id": "NP_001029440", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029440" } ] }, { "name": "endoplasmic reticulum DNA J domain-containing protein 3", "type": "synonym", "evidence": [ { "id": "NP_001029440", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029440" } ] } ], "function": [ { "annotation": "As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6#function" }, { "database": "UniProtKB", "id": "Q9UBS4", "url": "https://www.uniprot.org/uniprotkb/Q9UBS4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAJB11", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6", "locus": { "chromosome": "1", "start_pos": 80643691, "end_pos": 80665663, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003151", "url": "https://www.ensembl.org/id/ENSBTAG00000003151" } ] } } ], "crossref": [ { "id": "Q3ZBA6", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBA6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003151", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003151", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd10747", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10747", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506316", "url": "https://www.ncbi.nlm.nih.gov/gene/506316", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002939", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051736", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051736", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506316", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506316", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FAGRDFY", "url": "https://omabrowser.org/oma/group/FAGRDFY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBA6", "url": "https://www.orthodb.org/?gene=Q3ZBA6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44298", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44298", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44298:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44298:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01556", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01556", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029440", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBA6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBA6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPQNLGTFCLLLLYLIGTVIAGRDFYKILGVPRSASIKDIKKAYRKLALQLHPDRNPDDPRAQEKFQDLGAAYEVLSDSEKRKQYDTYGEEGLKDGHQSSHGDIFSHFFGDFGFMFGGTPRQQDRNIPRGSDIIVDLEVTLEEVYAGNFVEVVRNKPVARQAPGKRKCNCRQEMRTTQLGPGRFQMTQEVVCDECPNVKLVNEERTLEVEIEPGVRDGMEYPFIGEGEPHVDGEPGDLRFRIKVVKHSIFERRGDDLYTNVTISLVESLVGFDMDITHLDGHKVHISRDKITRPGAKLWKKGEGLPNFDNNNIKGSLIITFDVDFPKEQLSEEAREGIKQLLKQGSVQKVYNGLQGY", "length": 358, "header": "sp|Q3ZBA6-1|DJB11_BOVIN Isoform 1 of DnaJ homolog subfamily B member 11 OS=Bos taurus OX=9913 GN=DNAJB11 PE=2 SV=1 CANONICAL=Q3ZBA6-1" }, "isoforms": [ { "isoform_ac": "Q3ZBA6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6/entry#Q3ZBA6-1", "sequence": { "sequence": "MAPQNLGTFCLLLLYLIGTVIAGRDFYKILGVPRSASIKDIKKAYRKLALQLHPDRNPDDPRAQEKFQDLGAAYEVLSDSEKRKQYDTYGEEGLKDGHQSSHGDIFSHFFGDFGFMFGGTPRQQDRNIPRGSDIIVDLEVTLEEVYAGNFVEVVRNKPVARQAPGKRKCNCRQEMRTTQLGPGRFQMTQEVVCDECPNVKLVNEERTLEVEIEPGVRDGMEYPFIGEGEPHVDGEPGDLRFRIKVVKHSIFERRGDDLYTNVTISLVESLVGFDMDITHLDGHKVHISRDKITRPGAKLWKKGEGLPNFDNNNIKGSLIITFDVDFPKEQLSEEAREGIKQLLKQGSVQKVYNGLQGY", "length": 358, "header": "sp|Q3ZBA6-1|DJB11_BOVIN Isoform 1 of DnaJ homolog subfamily B member 11 OS=Bos taurus OX=9913 GN=DNAJB11 PE=2 SV=1 CANONICAL=Q3ZBA6-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 261, "start_aa": "Asn", "end_pos": 261, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn261", "evidence": [ { "id": "Q3ZBA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 188, "end_pos": 188, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6" } ], "site_lbl": "Thr188" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:506316", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506316", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1L1RR91-1", "protein_name": "DnaJ homolog subfamily B member 11", "gene_name": "DNAJB11", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAPGWLGRVCLLLLCLCGEAAAGRDFYKILGVSRGASVKDIKKAYRKLALQLHPDRNPDDPRAQEKFQDLGAAYEVLSDEEKRKQYDAYGEEGLKDGHQSSHGDIFSHFFGDFGFMFGGNPRQQDRNIPRGSDIIVDLEVTLEEVYSGNFVEVVRNKPVARQAPGKRKCNCRQEMRTTQLGPGRFQMTQEVVCDECPNVKLVNEERTLEVEIEPGVRDGMEYPFIGEGEPHVDGEPGDLRFRIKVLKHPVFERRGDDLYTNVTISLVEALTGFEMDITHLDGHKVHVARDKITKPGAKLWKKGEGLPNFDNNNIKGSLIITFDVEFPKEQLTSEQREGLKQLLKQGSVQKVYNGLQGY", "length": 358 }, "evidence": [ { "id": "Q3ZBA6", "url": "https://omabrowser.org/oma/group/Q3ZBA6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SFJ8-1", "protein_name": "DnaJ homolog subfamily B member 11", "gene_name": "DNAJB11", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAPQNLGTFCLLLLYLIGAVIAGRDFYKILGVPRSASIKDIKKAYRKLALQLHPDRNPDDPRAQEKFQDLGAAYEVLSDSEKRKQYDTYGEEGLKDGHQSSHGDIFSHFFGDFGFMFGGTPRQQDRNIPRGSDIIVDLEVTLEEVYAGNFVEVVRNKPVARQAPGKRKCNCRQEMRTTQLGPGRFQMTQEVVCDECPNVKLVNEERTLEVEIEPGVRDGMEYPFIGEGEPHVDGEPGDLRFRIKVVKHPIFERRGDDLYTNVTISLVESLVGFDMDITHLDGHKVHISRDKITRPGAKLWKKGEGLPNFDNNNIKGSLIITFDVDFPKEQLTEEAREGIKQLLKQGSVQKVYNGLQGY", "length": 358 }, "evidence": [ { "id": "Q3ZBA6", "url": "https://omabrowser.org/oma/group/Q3ZBA6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6TUG0-1", "protein_name": "DnaJ homolog subfamily B member 11", "gene_name": "Dnajb11", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAPQNLSTFCLLLLYLIGAVIAGRDFYKILGVPRSASIKDIKKAYRKLALQLHPDRNPDDPQAQEKFQDLGAAYEVLSDSEKRKQYDTYGEEGLKDGHQSSHGDIFSHFFGDFGFMFGGAPRQQDRNIPRGSDIIVDLEVTLEEVYAGNFVEVVRNKPVARQAPGKRKCNCRQEMRTTQLGPGRFQMTQEVVCDECPNVKLVNEERTLEVEIEPGVRDGMEYPFIGEGEPHVDGEPGDLRFRIKVVKHRIFERRGDDLYTNVTVSLVEALVGFEMDITHLDGHKVHISRDKITRPGAKLWKKGEGLPNFDNNNIKGSLIITFDVDFPKEQLTEEAKEGIKQLLKQGPVQKVYNGLQGY", "length": 358 }, "evidence": [ { "id": "Q3ZBA6", "url": "https://omabrowser.org/oma/group/Q3ZBA6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99KV1-1", "protein_name": "DnaJ homolog subfamily B member 11", "gene_name": "Dnajb11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPQNLSTFCLLLLYLIGTVIAGRDFYKILGVPRSASIKDIKKAYRKLALQLHPDRNPDDPQAQEKFQDLGAAYEVLSDSEKRKQYDTYGEEGLKDGHQSSHGDIFSHFFGDFGFMFGGTPRQQDRNIPRGSDIIVDLEVTLEEVYAGNFVEVVRNKPVARQAPGKRKCNCRQEMRTTQLGPGRFQMTQEVVCDECPNVKLVNEERTLEVEIEPGVRDGMEYPFIGEGEPHVDGEPGDLRFRIKVVKHRIFERRGDDLYTNVTVSLVEALVGFEMDITHLDGHKVHISRDKITRPGAKLWKKGEGLPNFDNNNIKGSLIITFDVDFPKEQLTEEAKEGIKQLLKQGPVQKVYNGLQGY", "length": 358 }, "evidence": [ { "id": "Q3ZBA6", "url": "https://omabrowser.org/oma/group/Q3ZBA6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UBS4-1", "protein_name": "DnaJ homolog subfamily B member 11", "gene_name": "DNAJB11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPQNLSTFCLLLLYLIGAVIAGRDFYKILGVPRSASIKDIKKAYRKLALQLHPDRNPDDPQAQEKFQDLGAAYEVLSDSEKRKQYDTYGEEGLKDGHQSSHGDIFSHFFGDFGFMFGGTPRQQDRNIPRGSDIIVDLEVTLEEVYAGNFVEVVRNKPVARQAPGKRKCNCRQEMRTTQLGPGRFQMTQEVVCDECPNVKLVNEERTLEVEIEPGVRDGMEYPFIGEGEPHVDGEPGDLRFRIKVVKHPIFERRGDDLYTNVTISLVESLVGFEMDITHLDGHKVHISRDKITRPGAKLWKKGEGLPNFDNNNIKGSLIITFDVDFPKEQLTEEAREGIKQLLKQGSVQKVYNGLQGY", "length": 358 }, "evidence": [ { "id": "Q3ZBA6", "url": "https://omabrowser.org/oma/group/Q3ZBA6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VPQ2-1", "protein_name": "DnaJ homolog shv", "gene_name": "shv", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MQLIKCLVIIQLSLLLVEESFAGRDFYKILNVKKNANTNEVKKAYRRLAKELHPDKNKDDPDASTKFQDLGAAYEVLSNPDKRKTYDRCGEECLKKEGMMDHGGDPFSSFFGDFGFHFGGDGQQQDAPRGADIVMDLYVSLEELYSGNFVEIVRNKPVTKPASGTRKCNCRQEMVTRNLGPGRFQMIQQTVCDECPNVKLVNEERTLEIEVEQGMVDGQETRFVAEGEPHIDGEPGDLIVRVQQMPHPRFLRKNDDLYTNVTISLQDALVGFSMEIKHLDGHLVPVTREKVTWPGARIRKKGEGMPNFENNNLTGNLYITFDVEFPKKDLTEEDKEALKKILDQSSINRIYNGL", "length": 354 }, "evidence": [ { "id": "Q3ZBA6", "url": "https://omabrowser.org/oma/group/Q3ZBA6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6" } ], "pmid": "" }, { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6" } ], "pmid": "" }, { "name": "misfolded protein binding", "id": "GO:0051787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051787", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6" } ], "pmid": "" }, { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBA6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBA6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 358, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBA6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBA6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZBA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBA6" }, { "id": "PRU00286", "database": "PROSITE", "url": 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"uniprot_id": "PHS_BOVIN", "mass": { "chemical_mass": 11986.0, "monoisotopic_mass": 11986.0 }, "refseq": { "ac": "NP_001193403", "name": "pterin-4-alpha-carbinolamine dehydratase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193403" }, "gene_names": [ { "name": "PCBD1", "type": "recommended", "evidence": [ { "id": "Q3ZBD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3" } ] }, { "name": "DCoH", "type": "synonym", "evidence": [ { "id": "NP_001193403", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193403" } ] }, { "name": "PCBD1", "type": "synonym", "evidence": [ { "id": "NP_001193403", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193403" } ] }, { "name": "PCD", "type": "synonym", "evidence": [ { "id": "NP_001193403", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193403" } ] }, { "name": "PHS", "type": "synonym", "evidence": [ { "id": "NP_001193403", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193403" } ] } ], "protein_names": [ { "name": "Pterin-4-alpha-carbinolamine dehydratase", "type": "recommended", "evidence": [ { "id": "Q3ZBD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3/entry#names_and_taxonomy" } ] }, { "name": "4-alpha-hydroxy-tetrahydropterin dehydratase", "type": "synonym", "evidence": [ { "id": "NP_001193403", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193403" }, { "id": "Q3ZBD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3/entry#names_and_taxonomy" } ] }, { "name": "4.2.1.96", "type": "synonym", "evidence": [ { "id": "Q3ZBD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3/entry#names_and_taxonomy" } ] }, { "name": "6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)", "type": "synonym", "evidence": [ { "id": "NP_001193403", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193403" } ] }, { "name": "DCoH", "type": "synonym", "evidence": [ { "id": "Q3ZBD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3/entry#names_and_taxonomy" } ] }, { "name": "Dimerization cofactor of HNF1", "type": "synonym", "evidence": [ { "id": "Q3ZBD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3/entry#names_and_taxonomy" } ] }, { "name": "Dimerization cofactor of hepatocyte nuclear factor 1-alpha", "type": "synonym", "evidence": [ { "id": "Q3ZBD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3/entry#names_and_taxonomy" } ] }, { "name": "PCD", "type": "synonym", "evidence": [ { "id": "Q3ZBD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3/entry#names_and_taxonomy" } ] }, { "name": "PHS", "type": "synonym", "evidence": [ { "id": "Q3ZBD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3/entry#names_and_taxonomy" } ] }, { "name": "Phenylalanine hydroxylase-stimulating protein", "type": "synonym", "evidence": [ { "id": "Q3ZBD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3/entry#names_and_taxonomy" } ] }, { "name": "Pterin carbinolamine dehydratase", "type": "synonym", "evidence": [ { "id": "Q3ZBD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3/entry#names_and_taxonomy" } ] }, { "name": "dimerization cofactor of HNF1", "type": "synonym", "evidence": [ { "id": "NP_001193403", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193403" } ] }, { "name": "dimerization cofactor of hepatocyte nuclear factor 1-alpha", "type": "synonym", "evidence": [ { "id": "NP_001193403", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193403" } ] }, { "name": "phenylalanine hydroxylase-stimulating protein", "type": "synonym", "evidence": [ { "id": "NP_001193403", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193403" } ] }, { "name": "pterin carbinolamine dehydratase", "type": "synonym", "evidence": [ { "id": "NP_001193403", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193403" } ] }, { "name": "pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)", "type": "synonym", "evidence": [ { "id": "NP_001193403", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193403" } ] }, { "name": "pterin-4-alpha-carbinolamine dehydratase", "type": "synonym", "evidence": [ { "id": "NP_001193403", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193403" } ] } ], "function": [ { "annotation": "Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity). Also acts as a coactivator for HNF1B-dependent transcription (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3#function" }, { "database": "UniProtKB", "id": "P61459", "url": "https://www.uniprot.org/uniprotkb/P61459#function" }, { "database": "UniProtKB", "id": "P61457", "url": "https://www.uniprot.org/uniprotkb/P61457#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCBD1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3", "locus": {} } ], "crossref": [ { "id": "Q3ZBD3", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBD3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011866", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011866", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00914", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00914", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "530736", "url": "https://www.ncbi.nlm.nih.gov/gene/530736", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001533", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001533", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036428", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036428", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530736", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530736", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WAEKWNH", "url": "https://omabrowser.org/oma/group/WAEKWNH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBD3", "url": "https://www.orthodb.org/?gene=Q3ZBD3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12599", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12599", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12599:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12599:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01329", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01329", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8964208", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8964208", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193403", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193403", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11920", "url": "https://www.rhea-db.org/rhea/11920", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3ZBD3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBD3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGKAHRLSAEERDQLLPNLRAVGWNELEGRDAIFKQFHFKDFNRAFGFMTRVALQAEKLDHHPEWFNVYNKVHITLSTHECAGLSERDVNLASFIEQVAVSMT", "length": 104, "header": "sp|Q3ZBD3-1|PHS_BOVIN Isoform 1 of Pterin-4-alpha-carbinolamine dehydratase OS=Bos taurus OX=9913 GN=PCBD1 PE=3 SV=2 CANONICAL=Q3ZBD3-1" }, "isoforms": [ { "isoform_ac": "Q3ZBD3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3/entry#Q3ZBD3-1", "sequence": { "sequence": "MAGKAHRLSAEERDQLLPNLRAVGWNELEGRDAIFKQFHFKDFNRAFGFMTRVALQAEKLDHHPEWFNVYNKVHITLSTHECAGLSERDVNLASFIEQVAVSMT", "length": 104, "header": "sp|Q3ZBD3-1|PHS_BOVIN Isoform 1 of Pterin-4-alpha-carbinolamine dehydratase OS=Bos taurus OX=9913 GN=PCBD1 PE=3 SV=2 CANONICAL=Q3ZBD3-1" }, "locus": { "chromosome": "28", "start_pos": 27072570, "end_pos": 27068232, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000138085.1", "url": "https://www.ensembl.org/id/ENSBTAT00000138085.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105090.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105090.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:530736", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530736", "resource": "KEGG Pathway" }, { "id": "R-BTA-8964208", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8964208", "resource": "Reactome", "description": "Phenylalanine metabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SUB1-1", "protein_name": "Pterin-4-alpha-carbinolamine dehydratase", "gene_name": "PCBD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGKAHRLSAEERDQLLPNLRAVGWNELEGRDAIFKQFHFKDFNRAFGFMTRVALQAEKLDHHPEWFNVYNKVHITLSTHECAGLSERDINLASFIEQVAVSMT", "length": 104 }, "evidence": [ { "id": "Q3ZBD3", "url": "https://omabrowser.org/oma/group/Q3ZBD3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O73930-1", "protein_name": "Pterin-4-alpha-carbinolamine dehydratase", "gene_name": "PCBD1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGKAHRLNAEEREQLLPNLRAVGWNEVEGRDAIFKEFHFKDFNRAFGFMTRVALQAEKLDHHPEWFNVYNKVHITLSTHECTGLSERDINLASFIEQVAASLS", "length": 104 }, "evidence": [ { "id": "Q3ZBD3", "url": "https://omabrowser.org/oma/group/Q3ZBD3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P61457-1", "protein_name": "Pterin-4-alpha-carbinolamine dehydratase", "gene_name": "PCBD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGKAHRLSAEERDQLLPNLRAVGWNELEGRDAIFKQFHFKDFNRAFGFMTRVALQAEKLDHHPEWFNVYNKVHITLSTHECAGLSERDINLASFIEQVAVSMT", "length": 104 }, "evidence": [ { "id": "Q3ZBD3", "url": "https://omabrowser.org/oma/group/Q3ZBD3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P61458-1", "protein_name": "Pterin-4-alpha-carbinolamine dehydratase", "gene_name": "Pcbd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGKAHRLSAEERDQLLPNLRAVGWNEVEGRDAIFKQFHFKDFNRAFGFMTRVALQAEKLDHHPEWFNVYNKVHITLSTHECAGLSERDINLASFIEQVAVSMT", "length": 104 }, "evidence": [ { "id": "Q3ZBD3", "url": "https://omabrowser.org/oma/group/Q3ZBD3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P61459-1", "protein_name": "Pterin-4-alpha-carbinolamine dehydratase", "gene_name": "Pcbd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGKAHRLSAEERDQLLPNLRAVGWNELEGRDAIFKQFHFKDFNRAFGFMTRVALQAEKLDHHPEWFNVYNKVHITLSTHECAGLSERDINLASFIEQVAVSMT", "length": 104 }, "evidence": [ { "id": "Q3ZBD3", "url": "https://omabrowser.org/oma/group/Q3ZBD3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3" } ], "pmid": "" }, { "name": "tetrahydrobiopterin biosynthetic process", "id": "GO:0006729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006729", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3" } ], "pmid": "" }, { "name": "4-alpha-hydroxytetrahydrobiopterin dehydratase activity", "id": "GO:0008124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008124", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3" } ], "pmid": "" }, { "name": "phenylalanine 4-monooxygenase activity", "id": "GO:0004505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004505", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBD3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11920", "name": "", "equation": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9TYR8-1", "Q3ZBD3-1" ], "evidence": [ { "id": "11920", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11920" } ] }, { "id": "R-BTA-71146", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-71112" ], "output_participant_list": [ "R-ALL-71129" ], "enzyme_list": [ "Q3ZBD3-1" ], "evidence": [ { "id": "R-BTA-71146", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71146" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-71112", "participant_name": "4aOH-BH4 [cytosol]", "crossref": [ { "id": "15642", "database": "ChEBI", "url": "" }, { "id": "C06486", "database": "COMPOUND", "url": "" }, { "id": "ZINC000033913759", "database": "ZINC", "url": "" }, { "id": "ZINC000033913758", "database": "ZINC", "url": "" }, { "id": "HMDB0002281", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-71129", "participant_name": "qDHB [cytosol]", "crossref": [ { "id": "HMDB0002215", "database": "HMDB Metabolite", "url": "" }, { "id": "43120", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9TYR8", "gene_name": "TXNDC15", "activity": [ { "ec_number": "4.2.1.96", "activity": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O.", "evidence": [ { "id": "A0AAA9TYR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYR8" } ] }, { "ec_number": "4.2.1.96", "activity": "", "evidence": [ { "id": "A0AAA9TYR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYR8" } ] } ] }, { "uniprot_ac": "Q3ZBD3", "gene_name": "PCBD1", "activity": [ { "ec_number": "4.2.1.96", "activity": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O.", "evidence": [ { "id": "Q3ZBD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3" } ] }, { "ec_number": "4.2.1.96", "activity": "", "evidence": [ { "id": "Q3ZBD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD3" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBD3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 104, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBD3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBD3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "4.2.1.96", "ec_name": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O.", "evidence": [ { "id": "4.2.1.96", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.96" }, { "id": "4.2.1.96", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=4.2.1.96" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBE0-1", "uniprot_ac": "Q3ZBE0", "uniprot_id": "DQX1_BOVIN", "mass": { "chemical_mass": 79397.0, "monoisotopic_mass": 79397.0 }, "refseq": { "ac": "NP_001030399", "name": "ATP-dependent RNA helicase homolog DQX1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030399" }, "gene_names": [ { "name": "DQX1", "type": "recommended", "evidence": [ { "id": "Q3ZBE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE0" } ] }, { "name": "DQX1", "type": "synonym", "evidence": [ { "id": "NP_001030399", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030399" } ] } ], "protein_names": [ { "name": "ATP-dependent RNA helicase homolog DQX1", "type": "recommended", "evidence": [ { "id": "Q3ZBE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE0/entry#names_and_taxonomy" } ] }, { "name": "ATP-dependent RNA helicase DQX1", "type": "synonym", "evidence": [ { "id": "NP_001030399", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030399" } ] }, { "name": "ATP-dependent RNA helicase homolog DQX1", "type": "synonym", "evidence": [ { "id": "NP_001030399", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030399" } ] }, { "name": "DEAQ box polypeptide 1 (RNA-dependent ATPase)", "type": "synonym", "evidence": [ { "id": "NP_001030399", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030399" } ] }, { "name": "DEAQ box polypeptide 1", "type": "synonym", "evidence": [ { "id": "Q3ZBE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Might be involved in RNA metabolism; it is missing helicase motif III and may not have helicase activity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE0#function" }, { "database": "UniProtKB", "id": "Q8TE96", "url": "https://www.uniprot.org/uniprotkb/Q8TE96#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DQX1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE0", "locus": { "chromosome": "11", "start_pos": 10120751, "end_pos": 10114072, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016609", "url": "https://www.ensembl.org/id/ENSBTAG00000016609" } ] } } ], "crossref": [ { "id": "Q3ZBE0", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBE0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016609", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016609", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18791", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18791", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517947", "url": "https://www.ncbi.nlm.nih.gov/gene/517947", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011709", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517947", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517947", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PPQWVLY", "url": "https://omabrowser.org/oma/group/PPQWVLY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBE0", "url": "https://www.orthodb.org/?gene=Q3ZBE0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18934", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18934", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18934:SF108", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18934:SF108", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04408", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04408", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07717", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07717", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030399", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBE0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBE0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASQLLGLEEESGPNPEESELAVNPFDGLPFSSRYYKLLEQRRSLPVWAARFIFLEHLESSPSGVVLVSGEPGCGKSTQIPQWCAEFVLARGFQKGWVTVTQPYPLAALSLALRVADEMDLTLGHEVGYSIPQEDCTGPDTLLRFCWDRLLLQEVASTRGTGARGVLILDEAQERSVASDLLQGLLRDARLGSLPGDLRVVVVTDPSLEPKLQDFWGGPPTVCVPRKTGSCPTPVYRDSLPADRVDAACQAVLEWCQEEAPGDVLVYLPSEEEISLCCESLSRKVRSLENQGPPPRVLPLHPGCGQAVQAVYEDTESGARKVVVTHWLADFSFSLPSIRHVIDSGLELRSVYSPQIRAESQVLRPVSKCQAEARRLRAAGIPPGSCLCLYPKSFLELEAPYLPQPRVWAENLSSLMLLLKRRQIAEPGKCHFLDRPAPEALMQALEDLDYLAALDDDGDLSDLGVILSEFPLAPELAKALLASCEFDCVDEMLTLAAMLTAAPGFTRPPVCAEEAALRRALEHVDGDHSSLIQVYEAFIQSGADKAWCQARGLNWAALCQARKLRGELLELMQRIELPLSQPAFGSERNRRDLQKALVSGYFLKVARDTDGTGNYLLLTHKHVAQLSPNCCYRSRRAPARPPLWVLYHSFSISKDNCLSIVSEIQPQMLVELAPPYFLSNLPPSESRDFLNQLREERTDSSIRSESSSTQELENACALQ", "length": 719, "header": "sp|Q3ZBE0-1|DQX1_BOVIN Isoform 1 of ATP-dependent RNA helicase homolog DQX1 OS=Bos taurus OX=9913 GN=DQX1 PE=2 SV=1 CANONICAL=Q3ZBE0-1" }, "isoforms": [ { "isoform_ac": "Q3ZBE0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE0/entry#Q3ZBE0-1", "sequence": { "sequence": "MASQLLGLEEESGPNPEESELAVNPFDGLPFSSRYYKLLEQRRSLPVWAARFIFLEHLESSPSGVVLVSGEPGCGKSTQIPQWCAEFVLARGFQKGWVTVTQPYPLAALSLALRVADEMDLTLGHEVGYSIPQEDCTGPDTLLRFCWDRLLLQEVASTRGTGARGVLILDEAQERSVASDLLQGLLRDARLGSLPGDLRVVVVTDPSLEPKLQDFWGGPPTVCVPRKTGSCPTPVYRDSLPADRVDAACQAVLEWCQEEAPGDVLVYLPSEEEISLCCESLSRKVRSLENQGPPPRVLPLHPGCGQAVQAVYEDTESGARKVVVTHWLADFSFSLPSIRHVIDSGLELRSVYSPQIRAESQVLRPVSKCQAEARRLRAAGIPPGSCLCLYPKSFLELEAPYLPQPRVWAENLSSLMLLLKRRQIAEPGKCHFLDRPAPEALMQALEDLDYLAALDDDGDLSDLGVILSEFPLAPELAKALLASCEFDCVDEMLTLAAMLTAAPGFTRPPVCAEEAALRRALEHVDGDHSSLIQVYEAFIQSGADKAWCQARGLNWAALCQARKLRGELLELMQRIELPLSQPAFGSERNRRDLQKALVSGYFLKVARDTDGTGNYLLLTHKHVAQLSPNCCYRSRRAPARPPLWVLYHSFSISKDNCLSIVSEIQPQMLVELAPPYFLSNLPPSESRDFLNQLREERTDSSIRSESSSTQELENACALQ", "length": 719, "header": "sp|Q3ZBE0-1|DQX1_BOVIN Isoform 1 of ATP-dependent RNA helicase homolog DQX1 OS=Bos taurus OX=9913 GN=DQX1 PE=2 SV=1 CANONICAL=Q3ZBE0-1" }, "locus": { "chromosome": "11", "start_pos": 10120451, "end_pos": 10114601, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033191.3", "url": "https://www.ensembl.org/id/ENSBTAT00000033191.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033112.2", "url": "https://www.ensembl.org/id/ENSBTAP00000033112.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 233, "start_aa": "Thr", "end_pos": 233, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr233", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:517947", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517947", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7KCE9-1", "protein_name": "ATP-dependent RNA helicase homolog DQX1", "gene_name": "Dqx1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLHVTPAAPVLVTRSLRPNYKQGKSPLVVAPQKHPALLPGKQVPLGRMDPKALSSVLWTATMASGRAEESEPSLGESELAVNPFDGLPFSSCYYELLEQRRALPIWAARFLFLEHLESSPTGVVLVSGEPGSGKSTQIPQWCAEFALARGFQTGQVTVTQPYPLAAMSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLLLQEVASTRGPGAWSVLIVDEAQERSVASDLLQGLLRDTKLRNLPGDPRVVVVTDPALEPKLQAFWANSPIVRVPREPGGNPTLVYRDTVPTDLVEAACQAVLELCRQEEAPGDVLVYLPSEEEISLCCESLSRELGMLAVPGPPPRVLPLHPGCGQAIQAVYEDTDMSVRKIVVTHWLADFSFSLPSIQHVIDSGLELRSVYSPRIRAESQVLRPISKCQAEARRLRARGFPPGSCLRLYSKSILELEAPPLPHPKVLEENLSSLVLLLKRKQIAEPGECHFLDRPAPEALMQALEDLDYLAALDDDGDLSDLGIILSEFPLLPELAKALLASCEFNCVDEMLTLSAMLTAAPGFTRPPLCAEEAALRRALEHADGDHSSLIQIYEAFVQSGADEVWCQARGLNWAALCQARKLRAELVELMQQIELPLSQPAFGSEQNRRDLQKALLSGFFLKVAQDIDGTGNYLLLTHKHVAQLSSCCSYRNRRAPAQPPAWVLYHSFSISKDNCLCIVSEIQPQMLVELAPPYFLSNLPPSESRDFLNQLREGPAAEAESSSPQEYGDGCVLQ", "length": 775 }, "evidence": [ { "id": "Q3ZBE0", "url": "https://omabrowser.org/oma/group/Q3ZBE0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D4A474-1", "protein_name": "ATP-dependent RNA helicase homolog DQX1", "gene_name": "Dqx1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASGLAEESEPSPGESELAVNPFDGLPFSSCYYELLEQRRALPIWAARFLFLEHLESSPTGVVLVSGEPGSGKSTQIPQWCAEFALARGFQTGQVTVTQPYPLAAMSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLVLDEAQERSVASDLLQGLLRDTRLRNLPGDPRVVIVTDSALEPKFQAFWGNSPTVHVPREPGENPTLTYKDTVPADLVEAACQAVLELCQREEAPGDVLVYLPSEEKWALVFLSLSKREMGMLAVPGPLPRVLPLHPGCGQAIQTVYEDTDVSVRKIVVTHWLADFSFSLPFIQHVIDSGLELRSVYNPRIRAESQVLRRISKCQAEARLLRARGFPPGTCLRLYSKSTLDLEAPPLPHPKVCEENLSSLVLLLKRKQIAEPGECHFLDRPAPEALMQALEDLDYLAALDDDGDLSDLGIILSEFPLPPELAKALLASCEFNCVDEMLTLAAMLTAAPGFTRPPLCAGEAALRRGLEHADGDHSSLIQVYEAFVQSGADETWCQARGLSWEALCQARKLRAELLELMQRIELPLSLPAFGSEQNRRDLQKALLSGYFLKVARDTDGTGNYLLLTHKHVAQLSPYCVYRNRRTPAQPPTWVLYHRFSISKDNCLCTVSEIQPEMLVELAPPYFLSNLPPSESRDLLNQLREGTEPSAAVTETASPQEYGDGCVLQ", "length": 718 }, "evidence": [ { "id": "Q3ZBE0", "url": "https://omabrowser.org/oma/group/Q3ZBE0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LG93-1", "protein_name": "ATP-dependent RNA helicase homolog DQX1", "gene_name": "DQX1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASQLLRLEESGPNPGESELAGNPFDGLPFSSRYYELLEQRRALPVWAARFIFLEQLESSPSGVVLVSGEPGSGKSTQIPQWCAEFVLARGFQKGRVTVTQPYPLAARSLALRVADEMDLTLGHEVGYSIPQEDCTGPDTLLRFCWDRLLLQEVASTRGTGAWGVLVLDEAQERSVASDLLQGLLRDARLGNLPGDARVVVITDPAFEPKLQAFWGNPPIVHVPREPGRWPIPVYRDTVPTDRVEAACQAVLKLCQKEAPGDVLVYLPSEEEISLCCESLSREVGSLENQGPPPRVLPLHPGRGQAVQAVYEDTDSGARKVVVTHWLADFSFSLPSVRHVIDSGLELRSVYNPQIRAESQVLRPISKCQAEARRLRATGVPPGSCLCLYPKSFLELEAPPLPQPRVCEENLSPLVLLLKRRQIAEPGKCDFLDRPAPEALMQALEDLDYLAALDDDGDLSDLGIILSEFPLAPELAKALLASCEFNCVDEMLTLAAMLTAAPGFTRPPLCAEEAALRRALEHVDGDHSSLIQVYEAFIQSGADEAWCQARGLNWAALCQACKLRGELLELMQRIELPLSPPAFGSEQNRRDLQKALVSGYFLKVARDTDGTGNYLLLTHKHVAQLSPYCCYRNRRAPARPPPWVLYHNFSISKDNCLSIVSEIQPEMLVELAPPYFLSNLPPSESRDLLNQLREEMADSSMGSDSSSTQELGHACVLQ", "length": 718 }, "evidence": [ { "id": "Q3ZBE0", "url": "https://omabrowser.org/oma/group/Q3ZBE0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8TE96-1", "protein_name": "ATP-dependent RNA helicase homolog DQX1", "gene_name": "DQX1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTSQPLRLAEEYGPSPGESELAVNPFDGLPFSSRYYELLKQRQALPIWAARFTFLEQLESNPTGVVLVSGEPGSGKSTQIPQWCAEFALARGFQKGQVTVTQPYPLAARSLALRVADEMDLTLGHEVGYSIPQEDCTGPNTLLRFCWDRLLLQEVASTRGTGAWGVLVLDEAQERSVASDSLQGLLQDARLEKLPGDLRVVVVTDPALEPKLRAFWGNPPIVHIPREPGERPSPIYWDTIPPDRVEAACQAVLELCRKELPGDVLVFLPSEEEISLCCESLSREVESLLLQGLPPRVLPLHPDCGRAVQAVYEDMDARKVVVTHWLADFSFSLPSIQHVIDSGLELRSVYNPRIRAEFQVLRPISKCQAEARRLRARGFPPGSCLCLYPKSFLELEAPPLPQPRVCEENLSSLVLLLKRRQIAEPGECHFLDQPAPEALMQALEDLDYLAALDDDGDLSDLGVILSEFPLAPELAKALLASCEFDCVDEMLTLAAMLTAAPGFTRPPLSAEEAALRRALEHTDGDHSSLIQVYEAFIQSGADEAWCQARGLNWAALCQAHKLRGELLELMQRIELPLSLPAFGSEQNRRDLQKALVSGYFLKVARDTDGTGNYLLLTHKHVAQLSSYCCYRSRRAPARPPPWVLYHNFTISKDNCLSIVSEIQPQMLVELAPPYFLSNLPPSESRDLLNQLREGMADSTAGSKSSSAQEFRDPCVLQ", "length": 717 }, "evidence": [ { "id": "Q3ZBE0", "url": "https://omabrowser.org/oma/group/Q3ZBE0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q924H9-1", "protein_name": "ATP-dependent RNA helicase homolog DQX1", "gene_name": "Dqx1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASGLAEESELSPGESELAVNPFDGLPFSSCYYELLEQRRALPIWAARFLFLEHLESSPTGVVLVSGDPGSGKSTQIPQWCAEFALARGFQTGQVTVTQPYPLAAMSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRDTRLRNLPGDPRVVVVTDPALEPKFQAFWGNSPIVRVPREPGGDPTLAYKDTVPTDLVEAACQAVLELCQQEEAPGDVLVYLPSEEEISLCCESLSGEMGTLAVPGPPPRVLPLHPGCAQAIQTVYEDTDVSVRKIVVTHWLADFSFSLPSIQHVIDSGLELRSVYNPRIRAESQVLRPISKCQAEARLLRAKGFPPGSCLRLYSKSTLELEAPPLPHPKVCEENLSSLVLLLMRKQIAEPGECHFLDRPAPEALMRALEDLDYLAALNDDGELSDLGVILSEFPLPPELAKALLASCEFNCVDEMLTLAAMLTAAPGFTRPPLSAGEAALRRALEHADGDHSSLIQVYEAFVQSGADEAWCQARGLNWESLCQARKLRAELVELMQRIELPLSQPAFGSEQNRRDLQKALLSGYFLKVARDTDGTGNYLLLTHKHVAQLSPYCSYRNRRTPAQPPTWVLYHSFSISKDNCLCIVSEIQPEMLVELAPPYFLSNLPPSESRDLLNQLREGTAEPPAAATETSSPQEYGDGCVLQ", "length": 718 }, "evidence": [ { "id": "Q3ZBE0", "url": "https://omabrowser.org/oma/group/Q3ZBE0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE0" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE0" } ], "pmid": "" }, { "name": "helicase activity", "id": "GO:0004386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004386", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBE0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 411, "end_pos": 413, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBE0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 719, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBE0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBE0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZBE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE0" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "DEAQ box", "eco_id": "ECO_0000250", "start_pos": 170, "end_pos": 173, "start_aa": "Asp", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3ZBE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE0" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Helicase ATP-binding", "eco_id": "ECO_0000250", "start_pos": 57, "end_pos": 225, "start_aa": "His", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3ZBE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBE0" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Helicase C-terminal", "eco_id": "ECO_0000250", "start_pos": 248, "end_pos": 449, "start_aa": "Ala", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 233 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 411, "end_pos": 413 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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}, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBF3-1", "uniprot_ac": "Q3ZBF3", "uniprot_id": "RM38_BOVIN", "mass": { "chemical_mass": 44622.0, "monoisotopic_mass": 44622.0 }, "refseq": { "ac": "NP_001030566", "name": "large ribosomal subunit protein mL38 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030566" }, "gene_names": [ { "name": "MRPL38", "type": "recommended", "evidence": [ { "id": "Q3ZBF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF3" } ] }, { "name": "MRPL38", "type": "synonym", "evidence": [ { "id": "NP_001030566", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030566" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein mL38", "type": "recommended", "evidence": [ { "id": "Q3ZBF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF3/entry#names_and_taxonomy" } ] }, { "name": "39S ribosomal protein L38, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001030566", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030566" }, { "id": "Q3ZBF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF3/entry#names_and_taxonomy" } ] }, { "name": "L38mt", "type": "synonym", "evidence": [ { "id": "NP_001030566", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030566" }, { "id": "Q3ZBF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF3/entry#names_and_taxonomy" } ] }, { "name": "MRP-L38", "type": "synonym", "evidence": [ { "id": "NP_001030566", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030566" }, { "id": "Q3ZBF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF3/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein mL38 precursor", "type": "synonym", "evidence": [ { "id": "NP_001030566", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030566" } ] }, { "name": "large ribosomal subunit protein mL38", "type": "synonym", "evidence": [ { "id": "NP_001030566", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030566" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBF3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRPL38", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF3", "locus": { "chromosome": "19", "start_pos": 55726175, "end_pos": 55721633, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022009", "url": "https://www.ensembl.org/id/ENSBTAG00000022009" } ] } } ], "crossref": [ { "id": "Q3ZBF3", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBF3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022009", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022009", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00866", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00866", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617005", "url": "https://www.ncbi.nlm.nih.gov/gene/617005", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036610", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036610", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617005", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617005", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PQKKFPH", "url": "https://omabrowser.org/oma/group/PQKKFPH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBF3", "url": "https://www.orthodb.org/?gene=Q3ZBF3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11362", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11362", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11362:SF133", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11362:SF133", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01161", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01161", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9937383", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030566", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBF3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBF3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPWWRVVLNGSRNWRGFSTSAALSRRAAPLGPMPNEDIDVSNLERLKKYRSFDRYRRRAEREARDPHWWRTYREHFGEESDPKDTVDIGLPPPKVCRTQQLLERKRVLRELRTSVEEERASRLRTASIPLEAVRAEWERTCGPYHKQRLAEYYGLYRDLFHGATFVPRVPLHVAYAIGEDDLVPVYYGNEVTPTEAAQPPEVTYEADEGSMWTLLLTNLDGHLLEPDAEYVHWLVTNIPGSRVAEGEETCPYLPPFPARGSGFHRFAFLLFKQDKPVDFSGDTRPSPCYQLAQRTFHTFDFYKKHQDAMTPAGLAFFQCRWDDSVTHIFHQLLDMREPVFEFVRPPPYHPKQKCFPHRQPLRYLDRYRDSHEPTYGFY", "length": 380, "header": "sp|Q3ZBF3-1|RM38_BOVIN Isoform 1 of Large ribosomal subunit protein mL38 OS=Bos taurus OX=9913 GN=MRPL38 PE=1 SV=2 CANONICAL=Q3ZBF3-1" }, "isoforms": [ { "isoform_ac": "Q3ZBF3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF3/entry#Q3ZBF3-1", "sequence": { "sequence": "MAAPWWRVVLNGSRNWRGFSTSAALSRRAAPLGPMPNEDIDVSNLERLKKYRSFDRYRRRAEREARDPHWWRTYREHFGEESDPKDTVDIGLPPPKVCRTQQLLERKRVLRELRTSVEEERASRLRTASIPLEAVRAEWERTCGPYHKQRLAEYYGLYRDLFHGATFVPRVPLHVAYAIGEDDLVPVYYGNEVTPTEAAQPPEVTYEADEGSMWTLLLTNLDGHLLEPDAEYVHWLVTNIPGSRVAEGEETCPYLPPFPARGSGFHRFAFLLFKQDKPVDFSGDTRPSPCYQLAQRTFHTFDFYKKHQDAMTPAGLAFFQCRWDDSVTHIFHQLLDMREPVFEFVRPPPYHPKQKCFPHRQPLRYLDRYRDSHEPTYGFY", "length": 380, "header": "sp|Q3ZBF3-1|RM38_BOVIN Isoform 1 of Large ribosomal subunit protein mL38 OS=Bos taurus OX=9913 GN=MRPL38 PE=1 SV=2 CANONICAL=Q3ZBF3-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 196, "start_aa": "Thr", "end_pos": 196, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr196", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle.", "journal": "Biochemistry", "date": "1999", "authors": "Graack HR, Bryant ML, O'Brien TW", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBF3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF3" } ], "reference": [ { "type": "PubMed", "id": "10600119", "url": "https://glygen.org/publication/PubMed/10600119" } ] }, { "title": "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Koc E C, Burkhart W, Blackburn K, Moyer M B, Schlatzer D M, Moseley A, Spremulli L L", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBF3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF3" } ], "reference": [ { "type": "PubMed", "id": "11551941", "url": "https://glygen.org/publication/PubMed/11551941" } ] } ], "pathway": [ { "id": "bta:617005", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617005", "resource": "KEGG Pathway" }, { "id": "R-BTA-5389840", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-9937383", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "resource": "Reactome", "description": "Mitochondrial ribosome-associated quality control" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RW03-1", "protein_name": "Large ribosomal subunit protein mL38", "gene_name": "MRPL38", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAPWWRAALCASRRWRGFSTSAALSRRAAPLGPMPNEDIDVSDLERLKKYRSFDRYRRRAEQEARKPHWWRTYREHFGEESGPKDRVDIGLPPPKVSRTQQLLERKQALRELRANVEEERAARLQTARIPLEAVRAEWERTCGPYHKQRLAEYCGLYRDLFHGATFVPRVPLHVAYAVGEDDLMPVYHGNEVTPTEAAQAPEVTYEADEGSLWTLLLTNLDGHLLEPDAEYVHWLVTNIPGNRVTEGQETCPYLPPFPARGSGFHRFAFLLFKQDKRIDFSGDTRPSPCYQLAQRTFHTFDFYKKHQDAMTPAGLAFFQCRWDDSVTRVFHQLLDMREPVFEFVRPPPYHPKQKRFPHRQPLRYLDRYRDSHEPTYGIY", "length": 380 }, "evidence": [ { "id": "Q3ZBF3", "url": "https://omabrowser.org/oma/group/Q3ZBF3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8K2M0-1", "protein_name": "Large ribosomal subunit protein mL38", "gene_name": "Mrpl38", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAPWWRAAFFGIGRCRGFSTSAFLSRRTPPLGPMPNEDIDVSNLERLEKYRSFERYRRRAEQEARAPHWWRTYREHFVKETDPKDKIDIGLPPPRVSRTQKLLERKHFLRELRANVEEERAARLRTASIPLEAVRAEWERTCGPYHKQRLAEYYGLYRDLFHGATFVPWVPLHVAYAVGEEDLIPVYHGNEVTPTEASRAPEVTYEADKDSLWTLLFINLDGHLLEPDAEYVHWLLTNIPSNRVAEGQETCPYLPPFPARGSGFHRFAFLLFKQDKPINFSEDTRPSPCYQLAQRTFRTFDFYKRHQEAMTPAGLAFFQCRWDDSVTHTFHQLLDMREPVFEFVRPPPYHPKQKRFPHEQPLRYLDRYRDSHEPTYGIY", "length": 380 }, "evidence": [ { "id": "Q3ZBF3", "url": "https://omabrowser.org/oma/group/Q3ZBF3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96DV4-1", "protein_name": "Large ribosomal subunit protein mL38", "gene_name": "MRPL38", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAPWWRAALCECRRWRGFSTSAVLGRRTPPLGPMPNSDIDLSNLERLEKYRSFDRYRRRAEQEAQAPHWWRTYREYFGEKTDPKEKIDIGLPPPKVSRTQQLLERKQAIQELRANVEEERAARLRTASVPLDAVRAEWERTCGPYHKQRLAEYYGLYRDLFHGATFVPRVPLHVAYAVGEDDLMPVYCGNEVTPTEAAQAPEVTYEAEEGSLWTLLLTSLDGHLLEPDAEYLHWLLTNIPGNRVAEGQVTCPYLPPFPARGSGIHRLAFLLFKQDQPIDFSEDARPSPCYQLAQRTFRTFDFYKKHQETMTPAGLSFFQCRWDDSVTYIFHQLLDMREPVFEFVRPPPYHPKQKRFPHRQPLRYLDRYRDSHEPTYGIY", "length": 380 }, "evidence": [ { "id": "Q3ZBF3", "url": "https://omabrowser.org/oma/group/Q3ZBF3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VY48-1", "protein_name": "Large ribosomal subunit protein mL38", "gene_name": "mRpL38", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSFSNLLMKSGLTVAVRDAQAAVLMTATRQGHTIRGKPPGVARSLEQRIREENVEDPEVVARINIGFPQLKESRSAQLKKRLEHLKSQRSDKQLEQLARSNKLIIDLDKVQRTYVKTTGQHDLRLVADHYGIFEHLFGSAYFVPRVPLNISYQLDGDSLAPVYNGNVIKPTEAAKAPQIDFDGLVDPITGQAAGQDTYWTLVASNPDAHYTNGTAECLHWFIANIPNGKVSEGQVLAEYLPPFPPRGVGYQRMVFVLYKQQARLDLGSYQLAAADYGNLEKRTFSTLDFYRQHQEQLTPAGLAFYQTNWDESLTQFYHDVLKIKEPVYEYDFPKPYLTDQKFFPLKQPFNLYMDKHRDQKQVNKEYLERKLAKTHPFEGPKKPLRYPNAHPIRDVPSWLRTEIRKERLGTGRVQDY", "length": 416 }, "evidence": [ { "id": "Q3ZBF3", "url": "https://omabrowser.org/oma/group/Q3ZBF3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBF3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF3" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBF3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 11, "end_pos": 13, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBF3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 380, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBF3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBF3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 196 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 11, "end_pos": 13 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBG8-1", "uniprot_ac": "Q3ZBG8", "uniprot_id": "MRNIP_BOVIN", "mass": { "chemical_mass": 40704.0, "monoisotopic_mass": 40704.0 }, "refseq": { "ac": "NP_001161415", "name": "MRN complex-interacting protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161415" }, "gene_names": [ { "name": "MRNIP", "type": "recommended", "evidence": [ { "id": "Q3ZBG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8" } ] }, { "name": "C7H5orf45", "type": "synonym", "evidence": [ { "id": "NP_001161415", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161415" } ] }, { "name": "MRNIP", "type": "synonym", "evidence": [ { "id": "NP_001161415", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161415" } ] } ], "protein_names": [ { "name": "MRN complex-interacting protein", "type": "recommended", "evidence": [ { "id": "Q3ZBG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8/entry#names_and_taxonomy" } ] }, { "name": "MRN complex-interacting protein", "type": "synonym", "evidence": [ { "id": "NP_001161415", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161415" } ] }, { "name": "MRN-interacting protein", "type": "synonym", "evidence": [ { "id": "NP_001161415", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161415" }, { "id": "Q3ZBG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8/entry#names_and_taxonomy" } ] }, { "name": "UPF0544 protein C5orf45 homolog", "type": "synonym", "evidence": [ { "id": "NP_001161415", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161415" } ] } ], "function": [ { "annotation": "Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8#function" }, { "database": "UniProtKB", "id": "Q6NTE8", "url": "https://www.uniprot.org/uniprotkb/Q6NTE8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRNIP", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8", "locus": { "chromosome": "7", "start_pos": 1435525, "end_pos": 1417994, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015602", "url": "https://www.ensembl.org/id/ENSBTAG00000015602" } ] } } ], "crossref": [ { "id": "Q3ZBG8", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBG8", "database": "AlphaFoldDB", "categories": [] }, { "id": "614757", "url": "https://www.ncbi.nlm.nih.gov/gene/614757", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032739", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032739", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614757", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614757", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3ZBG8", "url": "https://www.orthodb.org/?gene=Q3ZBG8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15863", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15863", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15863:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15863:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15749", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15749", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001161415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161415", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBG8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPPQQARVLRCCCCSLFQAHQVKKSLKWTCKACGKKQSFLQAYGEGSGADCRRHVQKLNLLQGQISEMSLRSLGESISANEEENVGPWQAARASPQETLQPSKNRWLKYLERDSKELGLKGGGVCFNSQPSSETEKPDPPFSTGLPRKRKWNQSTVQPLCGPHVQDSRNCEVTLKSLKARPLHPTWGARSSPDCSTWDLPCISEELPPSFTQDRAGLAGKGRESSREDLDTMELVPRGEPPCPAQQVRTMSKWEQCLGNSSHLDTEPLTPLQRGLRPIQAAQAEQGAPRAQTPREGGLCRLPGARQSPQTTHTPMPGPKWLCGRIPEQSQGTGPWAEGVPLVKGMQARSSLMRLCDLFKTGEDFDDDL", "length": 369, "header": "sp|Q3ZBG8-1|MRNIP_BOVIN Isoform 1 of MRN complex-interacting protein OS=Bos taurus OX=9913 GN=MRNIP PE=2 SV=1 CANONICAL=Q3ZBG8-1" }, "isoforms": [ { "isoform_ac": "Q3ZBG8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8/entry#Q3ZBG8-1", "sequence": { "sequence": "MAPPQQARVLRCCCCSLFQAHQVKKSLKWTCKACGKKQSFLQAYGEGSGADCRRHVQKLNLLQGQISEMSLRSLGESISANEEENVGPWQAARASPQETLQPSKNRWLKYLERDSKELGLKGGGVCFNSQPSSETEKPDPPFSTGLPRKRKWNQSTVQPLCGPHVQDSRNCEVTLKSLKARPLHPTWGARSSPDCSTWDLPCISEELPPSFTQDRAGLAGKGRESSREDLDTMELVPRGEPPCPAQQVRTMSKWEQCLGNSSHLDTEPLTPLQRGLRPIQAAQAEQGAPRAQTPREGGLCRLPGARQSPQTTHTPMPGPKWLCGRIPEQSQGTGPWAEGVPLVKGMQARSSLMRLCDLFKTGEDFDDDL", "length": 369, "header": "sp|Q3ZBG8-1|MRNIP_BOVIN Isoform 1 of MRN complex-interacting protein OS=Bos taurus OX=9913 GN=MRNIP PE=2 SV=1 CANONICAL=Q3ZBG8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 115, "end_pos": 115, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8" } ], "site_lbl": "Ser115" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614757", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614757", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8" } ], "pmid": "" }, { "name": "positive regulation of protein kinase activity", "id": "GO:0045860", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045860", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8" } ], "pmid": "" }, { "name": "response to ionizing radiation", "id": "GO:0010212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010212", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8" } ], "pmid": "" }, { "name": "mitotic G2 DNA damage checkpoint signaling", "id": "GO:0007095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007095", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8" } ], "pmid": "" }, { "name": "protein localization to chromatin", "id": "GO:0071168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071168", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8" } ], "pmid": "" }, { "name": "regulation of double-strand break repair via nonhomologous end joining", "id": "GO:2001032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001032", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8" } ], "pmid": "" }, { "name": "positive regulation of double-strand break repair via homologous recombination", "id": "GO:1905168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905168", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 153, "end_pos": 155, "annotation": "n_glycosylation_sequon" }, { "start_pos": 260, "end_pos": 262, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBG8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 369, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBG8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBG8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZBG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBG8" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Nuclear localization signal (NLS)", "eco_id": "ECO_0000250", "start_pos": 148, "end_pos": 151, "start_aa": "Arg", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 115 ], "sequon_annotation_sites": [ { "start_pos": 153, "end_pos": 155 }, { "start_pos": 260, "end_pos": 262 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q6Q7D1-1", "uniprot_ac": "Q6Q7D1", "uniprot_id": "DHI1L_BOVIN", "mass": { "chemical_mass": 31126.0, "monoisotopic_mass": 31126.0 }, "refseq": { "ac": "NP_996852", "name": "hydroxysteroid 11-beta-dehydrogenase 1-like protein precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996852" }, "gene_names": [ { "name": "HSD11B1L", "type": "recommended", "evidence": [ { "id": "Q6Q7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1" } ] }, { "name": "11-DH3", "type": "synonym", "evidence": [ { "id": "NP_996852", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996852" } ] }, { "name": "11-beta-HSD3", "type": "synonym", "evidence": [ { "id": "NP_996852", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996852" } ] }, { "name": "HSD11B1L", "type": "synonym", "evidence": [ { "id": "NP_996852", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996852" } ] }, { "name": "HSD3", "type": "synonym", "evidence": [ { "id": "Q6Q7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1" } ] } ], "protein_names": [ { "name": "Hydroxysteroid 11-beta-dehydrogenase 1-like protein", "type": "recommended", "evidence": [ { "id": "Q6Q7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1/entry#names_and_taxonomy" } ] }, { "name": "1.1.1.-", "type": "synonym", "evidence": [ { "id": "Q6Q7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1/entry#names_and_taxonomy" } ] }, { "name": "11-DH3", "type": "synonym", "evidence": [ { "id": "Q6Q7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1/entry#names_and_taxonomy" } ] }, { "name": "11-beta-HSD3", "type": "synonym", "evidence": [ { "id": "Q6Q7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1/entry#names_and_taxonomy" } ] }, { "name": "11-beta-hydroxysteroid dehydrogenase type 3", "type": "synonym", "evidence": [ { "id": "NP_996852", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996852" }, { "id": "Q6Q7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1/entry#names_and_taxonomy" } ] }, { "name": "hydroxysteroid 11-beta-dehydrogenase 1-like protein precursor", "type": "synonym", "evidence": [ { "id": "NP_996852", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996852" } ] }, { "name": "hydroxysteroid 11-beta-dehydrogenase 1-like protein", "type": "synonym", "evidence": [ { "id": "NP_996852", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996852" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7AMH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AMH5#function" }, { "database": "UniProtKB", "id": "ARBA00034092", "url": "https://www.uniprot.org/uniprotkb/ARBA00034092#function" } ] }, { "annotation": "Unidirectional NADP(+)-dependent cortisol dehydrogenase (in vitro).", "evidence": [ { "database": "UniProtKB", "id": "Q6Q7D1", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1#function" }, { "database": "UniProtKB", "id": "Q7Z5J1", "url": "https://www.uniprot.org/uniprotkb/Q7Z5J1#function" }, { "database": "UniProtKB", "id": "A0A452DIG2", "url": "https://www.uniprot.org/uniprotkb/A0A452DIG2#function" }, { "database": "UniProtKB", "id": "ARBA00093430", "url": "https://www.uniprot.org/uniprotkb/ARBA00093430#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6Q7D1", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HSD11B1L", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1", "locus": { "chromosome": "7", "start_pos": 18603998, "end_pos": 18614740, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001793", "url": "https://www.ensembl.org/id/ENSBTAG00000001793" } ] } } ], "crossref": [ { "id": "Q6Q7D1", "url": "https://alphafold.ebi.ac.uk/entry/Q6Q7D1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001793", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001793", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "404546", "url": "https://www.ncbi.nlm.nih.gov/gene/404546", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000509", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000509", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:404546", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404546", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DIG2", "url": "https://www.orthodb.org/?gene=A0A452DIG2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q6Q7D1", "url": "https://www.orthodb.org/?gene=Q6Q7D1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10114", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10114", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44279", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44279", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44279:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44279:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00106", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00106", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01158", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01158", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_996852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996852", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "68616", "url": "https://www.rhea-db.org/rhea/68616", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DIG2", "url": "https://www.uniprot.org/uniprotkb/A0A452DIG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIG2-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIG2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AMH5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AMH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AMH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AMH5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6Q7D1", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6Q7D1-1", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6Q7D1-2", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6Q7D1-3", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKVLLLTGLGALFFAYYWDDNFDPASLHGARVLLTGVSAGIGEELAYHYARLGSHLVLTAHTEALLQQVVGNCRKLGAPKVFYIAADMASPEVPERVVQFALDKLGGLDYLVLNHLGAAPAGTRVRSSQSTRWLMQMNFLSYVQLTSSALPSLTDSKGSLVVVSSLLGRVPTSFSSPYSAAKFALDSFFSSLRRELDVQEVNVAITMCVLGLRDRASAAEGVRGITRVRAAPGPKAALAVIRGGATRASGVFYPWRFHLLCLLRSWMPHSRAWFVRQELNITTPAAA", "length": 287, "header": "sp|Q6Q7D1-1|DHI1L_BOVIN Isoform 1 of Hydroxysteroid 11-beta-dehydrogenase 1-like protein OS=Bos taurus OX=9913 GN=HSD11B1L PE=2 SV=1 CANONICAL=Q6Q7D1-1" }, "isoforms": [ { "isoform_ac": "A0A452DIG2-1", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1/entry#A0A452DIG2-1", "sequence": { "sequence": "MKVLLLTGLGALFFAYYWDDNFDPASLHGARVLLTGVSAGIGEELAYHYARLGSHLVLTAHTEALLQQVVGNCRKLGAPKVFYIAADMASPEVPERVVQFAVDKLGGLDYLVLNHLGAAPAGTRVRSSQSTRWLMQAPPSWPWLSSPANAPTLSSERSPSPQAPPLPTKAFTPSPSGLGFLLRPVTRSRHLQMNFLSYVQLTSSALPSLTDSKGSLVVVSSLLGRVPTSFSSPYSAAKFALDSFFSSLRRELDVQEVNVAITMCVLGLRDRASAAEGVRGITRVRAAPGPKAALAVIRGGATRASGVFYPWRFHLLCLLRSWMPHSRAWFVRQELNITTPAAA", "length": 343, "header": "tr|A0A452DIG2-1|DHI1L_BOVIN Computationally mapped isoform of Hydroxysteroid 11-beta-dehydrogenase 1-like protein OS=Bos taurus OX=9913 GN=HSD11B1L PE=2 SV=2 CANONICAL=Q6Q7D1-1" }, "locus": { "chromosome": "7", "start_pos": 18614694, "end_pos": 18612206, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002346.5", "url": "https://www.ensembl.org/id/ENSBTAT00000002346.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002346.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002346.4" } ] } }, { "isoform_ac": "A0AAF7AMH5-1", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1/entry#A0AAF7AMH5-1", "sequence": { "sequence": "MALRYPMAVGLNKGHKVTKNVGKPRHSRRRGRLTKHTKFVRDMIREVCGFAPYERRAMELLKVSKDKRALKFIKKRVADTALPAVLLDEEGQHVGRQLGLALVQATEGTGLRNQGTQRLGASSGHTCRRLKGTSTLKSILEREHSVRNTVLWKGSPAFLTAG", "length": 162, "header": "tr|A0AAF7AMH5-1|DHI1L_BOVIN Computationally mapped isoform of Hydroxysteroid 11-beta-dehydrogenase 1-like protein OS=Bos taurus OX=9913 GN=HSD11B1L PE=2 SV=1 CANONICAL=Q6Q7D1-1" }, "locus": {} }, { "isoform_ac": "Q6Q7D1-1", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1/entry#Q6Q7D1-1", "sequence": { "sequence": "MKVLLLTGLGALFFAYYWDDNFDPASLHGARVLLTGVSAGIGEELAYHYARLGSHLVLTAHTEALLQQVVGNCRKLGAPKVFYIAADMASPEVPERVVQFALDKLGGLDYLVLNHLGAAPAGTRVRSSQSTRWLMQMNFLSYVQLTSSALPSLTDSKGSLVVVSSLLGRVPTSFSSPYSAAKFALDSFFSSLRRELDVQEVNVAITMCVLGLRDRASAAEGVRGITRVRAAPGPKAALAVIRGGATRASGVFYPWRFHLLCLLRSWMPHSRAWFVRQELNITTPAAA", "length": 287, "header": "sp|Q6Q7D1-1|DHI1L_BOVIN Isoform 1 of Hydroxysteroid 11-beta-dehydrogenase 1-like protein OS=Bos taurus OX=9913 GN=HSD11B1L PE=2 SV=1 CANONICAL=Q6Q7D1-1" }, "locus": {} }, { "isoform_ac": "Q6Q7D1-2", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1/entry#Q6Q7D1-2", "sequence": { "sequence": "MKVLLLTGLGALFFAYYWDDNFDPASLHGARVLLTGVSAGIGEELAYHYARLGSHLVLTAHTEALLQQAPPSWPWLSSPANAPTLSSERSPSPQAPPLPTKAFTPSPSGLGFLLRPVTRSRHLQMNFLSYVQLTSSALPSLTDSKGSLVVVSSLLGRVPTSFSSPYSAAKFALDSFFSSLRRELDVQEVNVAITMCVLGLRDRASAAEGVRGITRVRAAPGPKAALAVIRGGATRASGVFYPWRFHLLCLLRSWMPHSRAWFVRQELNITTPAAA", "length": 275, "header": "sp|Q6Q7D1-2|DHI1L_BOVIN Isoform 2 of Hydroxysteroid 11-beta-dehydrogenase 1-like protein OS=Bos taurus OX=9913 GN=HSD11B1L PE=2 SV=1 CANONICAL=Q6Q7D1-1" }, "locus": { "chromosome": "7", "start_pos": 18614694, "end_pos": 18612206, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113799.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113799.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094905.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094905.1" } ] } }, { "isoform_ac": "Q6Q7D1-3", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1/entry#Q6Q7D1-3", "sequence": { "sequence": "MKVLLLTGLGALFFAYYWDDNFDPGGLDYLVLNHLGAAPAGTRVRSSQSTRWLMQMNFLSYVQLTSSALPSLTDSKGSLVVVSSLLGRVPTSFSSPYSAAKFALDSFFSSLRRELDVQEVNVAITMCVLGLRDRASAAEGVRGITRVRAAPGPKAALAVIRGGATRASGVFYPWRFHLLCLLRSWMPHSRAWFVRQELNITTPAAA", "length": 206, "header": "sp|Q6Q7D1-3|DHI1L_BOVIN Isoform 3 of Hydroxysteroid 11-beta-dehydrogenase 1-like protein OS=Bos taurus OX=9913 GN=HSD11B1L PE=2 SV=1 CANONICAL=Q6Q7D1-1" }, "locus": { "chromosome": "7", "start_pos": 18614694, "end_pos": 18612206, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094660.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094660.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090903.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090903.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 280, "start_aa": "Asn", "end_pos": 280, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn280", "evidence": [ { "id": "Q6Q7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:404546", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404546", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q6Q7D1", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1" } ], "pmid": "" }, { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "Q6Q7D1", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q6Q7D1", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "Q6Q7D1", "url": "https://www.uniprot.org/uniprotkb/Q6Q7D1" } ], "pmid": "" }, { "name": "cortisol dehydrogenase (NADP+) activity", "id": "GO:0102196", "url": 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"length": 349, "header": "sp|Q5EA88-1|GPDA_BOVIN Isoform 1 of Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic OS=Bos taurus OX=9913 GN=GPD1 PE=2 SV=3 CANONICAL=Q5EA88-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWU8-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA88/entry#A0A3Q1LWU8-1", "sequence": { "sequence": "MAAAPLKVCIVGSGNWGSAVAKIIGNNVRKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAVANLSEAVQDADLLVFVIPHQFIHRICDEITGRVPKDALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAGKFCETTIGSKIMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLLCGDNTKAAVIRLGLMEMIAFARIFCKGQVSTATFLESCGVADLITTCYGGRNRKVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDKKEWTEKPGELQSMESQKSRHDLKHDLT", "length": 347, "header": "tr|A0A3Q1LWU8-1|GPDA_BOVIN Computationally mapped isoform of Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic OS=Bos taurus OX=9913 GN=GPD1 PE=2 SV=2 CANONICAL=Q5EA88-1" }, "locus": { "chromosome": "22", "start_pos": 6648685, "end_pos": 6594048, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067794.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067794.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061919.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061919.2" } ] } }, { "isoform_ac": "A0A3Q1M9X3-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA88/entry#A0A3Q1M9X3-1", "sequence": { "sequence": "MGSAVAKIIGNNVRKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAVANLSEAVQDADLLVFVIPHQFIHRICDEITGRVPKDALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAGKFCETTIGSKIMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLLCGDNTKAAVIRLGLMEMIAFARIFCKGQVSTATFLESCGVADLITTCYGGRNRKVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDKFPLFTAVYQICYEGRPVQEMLSCLQSHPEHI", "length": 336, "header": "tr|A0A3Q1M9X3-1|GPDA_BOVIN Computationally mapped isoform of Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic OS=Bos taurus OX=9913 GN=GPD1 PE=2 SV=2 CANONICAL=Q5EA88-1" }, "locus": { "chromosome": "22", "start_pos": 6655147, "end_pos": 6605914, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078690.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078690.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065295.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065295.2" } ] } }, { "isoform_ac": "A0A452DJJ3-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA88/entry#A0A452DJJ3-1", "sequence": { "sequence": "MSPLWGGRGVRTWAGAKGRSLPAPSAGKPKRKSGPGLCPIPVPHLSLSFPPLSLALPDSVSLGARLPSPGGRGLAAPTCVGVIYSQPAGELGRVAPSWRLRQRSSTMTGKKVCIVGSGNWGSAIAKIVGGNAAQLAHFDPRVTMWVFEEDIGGRKLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAAADADILIFVVPHQFIGKICDQLKGHLKADTIGVSLIKGVDEGPKGLKLISEVIGERLGIPMSVLMGANIANEVADEKFCETTIGSKNQAHGQLLKELMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGSVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKEMLNGQKLQGPQTARELHSILQHKGMVDKFPLFTAVYKVCYENQPVGEFIHCLQNHPEHV", "length": 455, "header": "tr|A0A452DJJ3-1|GPDA_BOVIN Computationally mapped isoform of Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic OS=Bos taurus OX=9913 GN=GPD1 PE=2 SV=1 CANONICAL=Q5EA88-1" }, "locus": { "chromosome": "5", "start_pos": 29795087, "end_pos": 29789765, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021683.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021683.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021683.5", "url": "https://www.ensembl.org/id/ENSBTAP00000021683.5" } ] } }, { "isoform_ac": "F6QT01-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA88/entry#F6QT01-1", "sequence": { "sequence": "MAAAPLKVCIVGSGNWGSAVAKIIGNNVRKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAVANLSEAVQDADLLVFVIPHQFIHRICDEITGRVPKDALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAGKFCETTIGSKIMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLLCGDNTKAAVIRLGLMEMIAFARIFCKGQVSTATFLESCGVADLITTCYGGRNRKVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDKFYQKSQWKSL", "length": 330, "header": "tr|F6QT01-1|GPDA_BOVIN Computationally mapped isoform of Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic OS=Bos taurus OX=9913 GN=GPD1 PE=2 SV=1 CANONICAL=Q5EA88-1" }, "locus": { "chromosome": "22", "start_pos": 6690786, "end_pos": 6594048, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012955.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012955.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012955.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012955.6" } ] } }, { "isoform_ac": "Q5EA88-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA88/entry#Q5EA88-1", "sequence": { "sequence": "MTGKKVCIVGSGNWGSAIAKIVGGNAAQLAHFDPRVTMWVFEEDIGGRKLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAAADADILIFVVPHQFIGKICDQLKGHLKADTIGVSLIKGVDEGPKGLKLISEVIGERLGIPMSVLMGANIANEVADEKFCETTIGSKNQAHGQLLKELMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGSVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKEMLNGQKLQGPQTARELHSILQHKGMVDKFPLFTAVYKVCYENQPVGEFIHCLQNHPEHV", "length": 349, "header": "sp|Q5EA88-1|GPDA_BOVIN Isoform 1 of Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic OS=Bos taurus OX=9913 GN=GPD1 PE=2 SV=3 CANONICAL=Q5EA88-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 326, "end_pos": 326, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA88", "url": "https://www.uniprot.org/uniprotkb/Q5EA88" } ], "site_lbl": "Tyr326" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA88", "url": "https://www.uniprot.org/uniprotkb/Q5EA88" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:525042", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525042", "resource": "KEGG Pathway" }, { "id": "R-BTA-1483166", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483166", "resource": "Reactome", "description": "Synthesis of PA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1WCQ0-1", "protein_name": "Glycerol-3-phosphate dehydrogenase [NAD(+)]", "gene_name": "GPD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTGKKVCIVGSGNWGSAIAKIVGGNAGRLAHFDPRVTMWVFEEDVGGRKLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQASADADILIFVVPHQFIGKICDQLKGHLKADAIGLSLIKGVDEGPDGLKLISEVIGERLGIPMSVLMGANIANEVADEKFCETTIGCKDLAQGQLLKELMQTPNFRVTVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCHGPVSSATFLESCGIADLITTCYGGRNRKVAEAFARTGKSIEQLEKEMLNGQKLQGPQTAQELHSILQHKGLVDKFPLFMAVYKICYENHPVSEFICCLQNHPEHS", "length": 349 }, "evidence": [ { "id": "Q5EA88", "url": "https://omabrowser.org/oma/group/Q5EA88/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2QF99-1", "protein_name": "Glycerol-3-phosphate dehydrogenase [NAD(+)]", "gene_name": "Gpd1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAGKKVCIVGSGNWGSAIAKIVGSNAARLAHFDPRVTMWVFEEDIGGRKLTEIINTQHENVKYLPGHKLPPNVVAVPDIVQAAVDADILIFVVPHQFIGKICDQLKGHLKANTIGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCETTIGCKDSAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCRGSVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKEMLNGQKLQGPQTARELHSILQHKGLVDKFPLFTAVYKVCYEGQPVGEFIRCLQNHPEHM", "length": 349 }, "evidence": [ { "id": "Q5EA88", "url": "https://omabrowser.org/oma/group/Q5EA88/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0ZZ88-1", "protein_name": "Glycerol-3-phosphate dehydrogenase [NAD(+)]", "gene_name": "GPD1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGGKKVCIVGSGNWGSAIAKIVGSNAARLGTFENTVNMWVLEEEVGGRRLTEIINTEHENVKYLPGHKLPPNVVAEPDLVKACSGADILLFVVPHQFIGKVCDQIKAHVKKGAIGMSLIKGVDEGPDGLRLISDIIHEKLGIEMSVLMGANIASEVAEEKFCETTIGCKNAQYGQILKELMQTPNFRVTVVQEADTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMISFAKIFCKGPVTPSTFLESCGVADLITTCYGGRNRKVAEAFAKTGKSIEQLEKEMLNGQKLQGPQTSAELNHILKTKNMVDKFPLFTAVYQICYEGKPVSDVIKCLQNHPEHM", "length": 349 }, "evidence": [ { "id": "Q5EA88", "url": "https://omabrowser.org/oma/group/Q5EA88/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O35077-1", "protein_name": "Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic", "gene_name": "Gpd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGKKVCIVGSGNWGSAIAKIVGSNASQLAHFDPRVTMWVFEEDIGGRKLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAATGADILVFVVPHQFIGKICDQLKGHLKANTIGISLIKGIDEGPNGLKLISEVIGESLGIPMSVLMGANIASEVAEEKFCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGSVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKEMLNGQKLQGPQTARELHSILQHKGLVDKFPLFTAVYKVCYEGQPVGEFICCLQNHPEHM", "length": 349 }, "evidence": [ { "id": "Q5EA88", "url": "https://omabrowser.org/oma/group/Q5EA88/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P13706-3", "protein_name": "Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic", "gene_name": "Gpdh1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MADKVNVCIVGSGNWGSAIAKIVGANAAALPEFEERVTMFVYEELIDGKKLTEIINETHENVKYLKGHKLPPNVVAVPDLVEAAKNADILIFVVPHQFIPNFCKQLLGKIKPNAIAISLIKGFDKAEGGGIDLISHIITRHLKIPCAVLMGANLANEVAEGNFCETTIGCTDKKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDNTKAAVIRLGLMEMIRFVDVFYPGSKLSTFFESCGVADLITTCYGGRNRRVSEAFVTSGKTIEELEKEMLNGQKLQGPPTAEEVNYMLKNKGLEDKFPLFTAIHKICTNQLKPNDLIDCIRNHPEHMDTSIMPSPKL", "length": 360 }, "evidence": [ { "id": "Q5EA88", "url": "https://omabrowser.org/oma/group/Q5EA88/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P13707-1", "protein_name": "Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic", "gene_name": "Gpd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGKKVCIVGSGNWGSAIAKIVGSNAGRLAHFDPRVTMWVFEEDIGGRKLTEIINTQHENVKYLPGHKLPPNVVAIPDVVQAATGADILVFVVPHQFIGKICDQLKGHLKANTIGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVAEEKFCETTIGCKDPAQGQLLKDLMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGTVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKEMLNGQKLQGPQTARELHSILQHKGLVDKFPLFTAVYKVCYEGQPVGEFIRCLQNHPEHM", "length": 349 }, "evidence": [ { "id": "Q5EA88", "url": "https://omabrowser.org/oma/group/Q5EA88/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P21695-1", "protein_name": "Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic", "gene_name": "GPD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASKKVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAAEDADILIFVVPHQFIGKICDQLKGHLKANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGPVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGPETARELYSILQHKGLVDKFPLFMAVYKVCYEGQPVGEFIHCLQNHPEHM", "length": 349 }, "evidence": [ { "id": "Q5EA88", "url": "https://omabrowser.org/oma/group/Q5EA88/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P41911-1", "protein_name": "Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, mitochondrial", "gene_name": "GPD2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MLAVRRLTRYTFLKRTHPVLYTRRAYKILPSRSTFLRRSLLQTQLHSKMTAHTNIKQHKHCHEDHPIRRSDSAVSIVHLKRAPFKVTVIGSGNWGTTIAKVIAENTELHSHIFEPEVRMWVFDEKIGDENLTDIINTRHQNVKYLPNIDLPHNLVADPDLLHSIKGADILVFNIPHQFLPNIVKQLQGHVAPHVRAISCLKGFELGSKGVQLLSSYVTDELGIQCGALSGANLAPEVAKEHWSETTVAYQLPKDYQGDGKDVDHKILKLLFHRPYFHVNVIDDVAGISIAGALKNVVALACGFVEGMGWGNNASAAIQRLGLGEIIKFGRMFFPESKVETYYQESAGVADLITTCSGGRNVKVATYMAKTGKSALEAEKELLNGQSAQGIITCREVHEWLQTCELTQEFPLFEAVYQIVYNNVRMEDLPEMIEELDIDDE", "length": 440 }, "evidence": [ { "id": "Q5EA88", "url": "https://omabrowser.org/oma/group/Q5EA88/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "glycerol-3-phosphate dehydrogenase (quinone) activity", "id": "GO:0004368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004368", "evidence": [ { "database": "UniProtKB", "id": "Q5EA88", "url": "https://www.uniprot.org/uniprotkb/Q5EA88" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q5EA88", "url": "https://www.uniprot.org/uniprotkb/Q5EA88" } ], "pmid": "" }, { "name": "NAD binding", "id": "GO:0051287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051287", "evidence": [ { "database": "UniProtKB", "id": "Q5EA88", "url": "https://www.uniprot.org/uniprotkb/Q5EA88" } ], "pmid": "" }, { "name": "glycerol-3-phosphate dehydrogenase [NAD(P)+] activity", "id": "GO:0047952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047952", "evidence": [ { "database": "UniProtKB", "id": "Q5EA88", "url": "https://www.uniprot.org/uniprotkb/Q5EA88" } ], "pmid": "" }, { "name": "glycerol-3-phosphate dehydrogenase (NAD+) activity", "id": "GO:0141152", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141152", "evidence": [ { "database": "UniProtKB", "id": "Q5EA88", "url": "https://www.uniprot.org/uniprotkb/Q5EA88" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5EA88", "url": "https://www.uniprot.org/uniprotkb/Q5EA88" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5EA88", "url": "https://www.uniprot.org/uniprotkb/Q5EA88" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "Q5EA88", "url": "https://www.uniprot.org/uniprotkb/Q5EA88" } ], "pmid": "" }, { "name": "gluconeogenesis", "id": "GO:0006094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006094", "evidence": [ { "database": "UniProtKB", "id": "Q5EA88", "url": "https://www.uniprot.org/uniprotkb/Q5EA88" } ], "pmid": "" }, { "name": "glycerol-3-phosphate metabolic process", "id": "GO:0006072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006072", "evidence": [ { "database": "UniProtKB", "id": "Q5EA88", "url": "https://www.uniprot.org/uniprotkb/Q5EA88" } ], "pmid": "" }, { "name": "glycerol-3-phosphate catabolic process", "id": "GO:0046168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046168", "evidence": [ { "database": "UniProtKB", "id": "Q5EA88", "url": "https://www.uniprot.org/uniprotkb/Q5EA88" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11092", "name": "", "equation": "sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5EA88-1" ], "evidence": [ { "id": "11092", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11092" } ] }, { "id": "R-BTA-75889", "name": "DHAP is converted to G3P by GPD1/GPD1L", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-75970" ], "output_participant_list": [], "enzyme_list": [ "Q5EA88-1" ], "evidence": [ { "id": "R-BTA-75889", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75889" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-75970", "participant_name": "DHAP [cytosol]", "crossref": [ { "id": "57642", "database": "ChEBI", "url": "" }, { "id": "ZINC000024492326", "database": "ZINC", "url": "" }, { "id": "C00111", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q5EA88", "gene_name": "GPD1", "activity": [ { "ec_number": "1.1.1.8", "activity": "sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+).", "evidence": [ { "id": "Q5EA88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA88" } ] }, { "ec_number": "1.1.1.8", "activity": "", "evidence": [ { "id": "Q5EA88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA88" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA88-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 349, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA88-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA88" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.1.1.8", "ec_name": "sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+).", "evidence": [ { "id": "1.1.1.8", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.8" }, { "id": "1.1.1.8", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.1.1.8" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 326 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q8SQ21-1", "uniprot_ac": "Q8SQ21", "uniprot_id": "HINT2_BOVIN", "mass": { "chemical_mass": 17147.0, "monoisotopic_mass": 17147.0 }, "refseq": { "ac": "NP_776765", "name": "adenosine 5'-monophosphoramidase HINT2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776765" }, "gene_names": [ { "name": "HINT2", "type": "recommended", "evidence": [ { "id": "Q8SQ21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SQ21" } ] }, { "name": "HINT2", "type": "synonym", "evidence": [ { "id": "NP_776765", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776765" } ] } ], "protein_names": [ { "name": "Adenosine 5'-monophosphoramidase HINT2", "type": "recommended", "evidence": [ { "id": "Q8SQ21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SQ21/entry#names_and_taxonomy" } ] }, { "name": "3.9.1.-", "type": "synonym", "evidence": [ { "id": "Q8SQ21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SQ21/entry#names_and_taxonomy" } ] }, { "name": "HINT-2", "type": "synonym", "evidence": [ { "id": "NP_776765", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776765" }, { "id": "Q8SQ21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SQ21/entry#names_and_taxonomy" } ] }, { "name": "HINT-3", "type": "synonym", "evidence": [ { "id": "NP_776765", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776765" }, { "id": "Q8SQ21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SQ21/entry#names_and_taxonomy" } ] }, { "name": "Histidine triad nucleotide-binding protein 2, mitochondrial", "type": "synonym", "evidence": [ { "id": "Q8SQ21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SQ21/entry#names_and_taxonomy" } ] }, { "name": "adenosine 5'-monophosphoramidase HINT2 precursor", "type": "synonym", "evidence": [ { "id": "NP_776765", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776765" } ] }, { "name": "adenosine 5'-monophosphoramidase HINT2", "type": "synonym", "evidence": [ { "id": "NP_776765", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776765" } ] }, { "name": "histidine triad nucleotide-binding protein 2, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_776765", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776765" } ] } ], "function": [ { "annotation": "Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) (By similarity). May be involved in steroid biosynthesis (By similarity). May play a role in apoptosis (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q8SQ21", "url": "https://www.uniprot.org/uniprotkb/Q8SQ21#function" }, { "database": "UniProtKB", "id": "Q9BX68", "url": "https://www.uniprot.org/uniprotkb/Q9BX68#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q8SQ21", "url": "https://www.uniprot.org/uniprotkb/Q8SQ21" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HINT2", "url": "https://www.uniprot.org/uniprotkb/Q8SQ21", "locus": { "chromosome": "8", "start_pos": 59979706, "end_pos": 59982358, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011444", "url": "https://www.ensembl.org/id/ENSBTAG00000011444" } ] } } ], "crossref": [ { "id": "Q8SQ21", "url": "https://alphafold.ebi.ac.uk/entry/Q8SQ21", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011444", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011444", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01276", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01276", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "281816", "url": "https://www.ncbi.nlm.nih.gov/gene/281816", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001310", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001310", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011146", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011146", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019808", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019808", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036265", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036265", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281816", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281816", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YRVVMNC", "url": "https://omabrowser.org/oma/group/YRVVMNC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M4I4", "url": "https://www.orthodb.org/?gene=A0A3Q1M4I4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MXK6", "url": "https://www.orthodb.org/?gene=A0A3Q1MXK6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q8SQ21", "url": "https://www.orthodb.org/?gene=Q8SQ21", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23089", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23089", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01230", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01230", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_776765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776765", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "67916", "url": "https://www.rhea-db.org/rhea/67916", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M4I4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4I4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4I4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4I4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MXK6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXK6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MXK6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXK6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YW67", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW67", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YW67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YW67-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8SQ21", "url": "https://www.uniprot.org/uniprotkb/Q8SQ21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8SQ21-1", "url": "https://www.uniprot.org/uniprotkb/Q8SQ21-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAVVLAAGLCVARRAVAVAGPRGVQVRGAAGVTDGDEVAKAQQAAPGGAAPTIFSRILDRSLPADILYEDQQCLAFRDVAPQAPVHFLVIPKKPIPRISQAEEEDQQLLGHLLLVAKETAKAEGLGDGYRLVINDGKLGAQSVYHLHIHVLGGRQLQWPPG", "length": 163, "header": "sp|Q8SQ21-1|HINT2_BOVIN Isoform 1 of Adenosine 5'-monophosphoramidase HINT2 OS=Bos taurus OX=9913 GN=HINT2 PE=2 SV=1 CANONICAL=Q8SQ21-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M4I4-1", "url": "https://www.uniprot.org/uniprotkb/Q8SQ21/entry#A0A3Q1M4I4-1", "sequence": { "sequence": "MTYAAHRPWPRGRHKVRGAAGVTDGDEVAKAQQAAPGGAAPTIFSRILDRSLPADILYEDQQCLAFRDVAPQAPVHFLVIPKKPIPRISQAEEEDQQLLGHLLLVAKETAKAEGLGDGYRLVINDGKLGAQSVYHLHIHVLGGRQLQWPPG", "length": 151, "header": "tr|A0A3Q1M4I4-1|HINT2_BOVIN Computationally mapped isoform of Adenosine 5'-monophosphoramidase HINT2 OS=Bos taurus OX=9913 GN=HINT2 PE=2 SV=1 CANONICAL=Q8SQ21-1" }, "locus": { "chromosome": "8", "start_pos": 59981513, "end_pos": 59979801, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069962.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069962.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068498.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068498.1" } ] } }, { "isoform_ac": "A0A3Q1MXK6-1", "url": "https://www.uniprot.org/uniprotkb/Q8SQ21/entry#A0A3Q1MXK6-1", "sequence": { "sequence": "KIHPRVGTRSQWDEKIPQRPWRRSQWSAGPRNATQWDDGVRFRPRPEPIAVARRLPAAPPQQAAELELLAQVRGAAGVTDGDEVAKAQQAAPGGAAPTIFSRILDRSLPADILYEDQQCLAFRDVAPQAPVHFLVIPKKPIPRISQAEEEDQQLLGHLLLVAKETAKAEGLGDGYRLVINDGKLGAQSVYHLHIHVLGGRQLQWPPG", "length": 207, "header": "tr|A0A3Q1MXK6-1|HINT2_BOVIN Computationally mapped isoform of Adenosine 5'-monophosphoramidase HINT2 OS=Bos taurus OX=9913 GN=HINT2 PE=2 SV=2 CANONICAL=Q8SQ21-1" }, "locus": { "chromosome": "8", "start_pos": 59982159, "end_pos": 59979801, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067641.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067641.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060490.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060490.2" } ] } }, { "isoform_ac": "A0AAF6YW67-1", "url": "https://www.uniprot.org/uniprotkb/Q8SQ21/entry#A0AAF6YW67-1", "sequence": { "sequence": "MAAAVVLAAGLCVARRAVAVAGPRGVQVRGAAGVTDGDEVAKAQQAAPGGAAPTIFSRILDRSLPADILYEDQQCLAFRDVAPQAPVHFLVIPKKPIPRISQAEEEDQQKFCSLINEETAKAEGLGDGYRLVINDGKLGAQSVYHLHIHVLGGRQLQWPPG", "length": 161, "header": "tr|A0AAF6YW67-1|HINT2_BOVIN Computationally mapped isoform of Adenosine 5'-monophosphoramidase HINT2 OS=Bos taurus OX=9913 GN=HINT2 PE=2 SV=1 CANONICAL=Q8SQ21-1" }, "locus": { "chromosome": "8", "start_pos": 59981918, "end_pos": 59979801, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015208.3", "url": "https://www.ensembl.org/id/ENSBTAT00000015208.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015208.2", "url": "https://www.ensembl.org/id/ENSBTAP00000015208.2" } ] } }, { "isoform_ac": "Q8SQ21-1", "url": "https://www.uniprot.org/uniprotkb/Q8SQ21/entry#Q8SQ21-1", "sequence": { "sequence": "MAAAVVLAAGLCVARRAVAVAGPRGVQVRGAAGVTDGDEVAKAQQAAPGGAAPTIFSRILDRSLPADILYEDQQCLAFRDVAPQAPVHFLVIPKKPIPRISQAEEEDQQLLGHLLLVAKETAKAEGLGDGYRLVINDGKLGAQSVYHLHIHVLGGRQLQWPPG", "length": 163, "header": "sp|Q8SQ21-1|HINT2_BOVIN Isoform 1 of Adenosine 5'-monophosphoramidase HINT2 OS=Bos taurus OX=9913 GN=HINT2 PE=2 SV=1 CANONICAL=Q8SQ21-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "evidence": [ { "id": "28100784", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28100784" }, { "id": "Q8SQ21", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8SQ21" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Mitochondrial O-GlcNAc Transferase (mOGT) Regulates Mitochondrial Structure, Function, and Survival in HeLa Cells.", "journal": "The Journal of biological chemistry", "date": "2017", "authors": "Sacoman JL, Dagda RY, Burnham-Marusich AR, Dagda RK, Berninsone PM", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8SQ21", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8SQ21" } ], "reference": [ { "type": "PubMed", "id": "28100784", "url": "https://glygen.org/publication/PubMed/28100784" } ] } ], "pathway": [ { "id": "bta:281816", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281816", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q04344-1", "protein_name": "Adenosine 5'-monophosphoramidase HNT1", "gene_name": "HNT1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MEPLISAPYLTTTKMSAPATLDAACIFCKIIKSEIPSFKLIETKYSYAFLDIQPTAEGHALIIPKYHGAKLHDIPDEFLTDAMPIAKRLAKAMKLDTYNVLQNNGKIAHQEVDHVHFHLIPKRDEKSGLIVGWPAQETDFDKLGKLHKELLAKLEGSD", "length": 158 }, "evidence": [ { "id": "Q8SQ21", "url": "https://omabrowser.org/oma/group/Q8SQ21/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54HJ0-1", "protein_name": "HIT domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSESGAKAGATEENNRIDPKDTLFAKFVSGQIQVPKVYEDEYCIAINDINPQAPVHILVIPKLAVGGVSDVANVDLEKYKEAMGHIMSKIHHIASLKGADSYRLVINDGVLGQQSVRWLHIHILGGRQMNWPPG", "length": 134 }, "evidence": [ { "id": "Q8SQ21", "url": "https://omabrowser.org/oma/group/Q8SQ21/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8GUN2-1", "protein_name": "Adenylylsulfatase HINT1", "gene_name": "HINT1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSHRVSILSSHFSPASAVMASEKEAALAATPSDSPTIFDKIISKEIPSTVVFEDDKVLAFRDITPQGPVHILLIPKVRDGLTGLSKAEERHIDILGRLLYTAKLVAKQEGLAEGFRIVINDGPQGCQSVYHIHVHLIGGRQMNWPPG", "length": 147 }, "evidence": [ { "id": "Q8SQ21", "url": "https://omabrowser.org/oma/group/Q8SQ21/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9BX68-1", "protein_name": "Adenosine 5'-monophosphoramidase HINT2", "gene_name": "HINT2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAVVLAAGLRAARRAVAATGVRGGQVRGAAGVTDGNEVAKAQQATPGGAAPTIFSRILDKSLPADILYEDQQCLVFRDVAPQAPVHFLVIPKKPIPRISQAEEEDQQLLGHLLLVAKQTAKAEGLGDGYRLVINDGKLGAQSVYHLHIHVLGGRQLQWPPG", "length": 163 }, "evidence": [ { "id": "Q8SQ21", "url": "https://omabrowser.org/oma/group/Q8SQ21/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D0S9-1", "protein_name": "Adenosine 5'-monophosphoramidase HINT2", "gene_name": "Hint2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"url": "https://www.uniprot.org/uniprotkb/A0A3Q1N6D4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N6D4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N6D4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NB55", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NB55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NB55-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NB55-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z038", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z038", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z038-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z038-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYP3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYP3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYP3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9M8", "url": "https://www.uniprot.org/uniprotkb/Q5E9M8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9M8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9M8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGELPPNINIKEPRWDQSTFIGRAKHFFTVTDPRNILLTNEQLEAARKVVHDYRQGIIPSGLTENELWRAKYIYDSAFHPDTGEKMILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPVQVGIVGFCLVFATPLCCALFPQKSSMSVTSLEAELQARIRETYPELRRVYFNKGL", "length": 322, "header": "sp|Q5E9M8-1|SFXN1_BOVIN Isoform 1 of Sideroflexin-1 OS=Bos taurus OX=9913 GN=SFXN1 PE=2 SV=3 CANONICAL=Q5E9M8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N6D4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9M8/entry#A0A3Q1N6D4-1", "sequence": { "sequence": "MSGELPPNINIKEPRWDQSTFIGRAKHFFTVTDPRNILLTNEQLEAARKVVHDYRQGIIPSGLTENELWRAKYIYDSAFHPDTGEKMILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAAPGMGEENLGTCSCTWQVSVEQALVCHSMSVTSLEAELQARIRETYPELRRVYFNKGL", "length": 295, "header": "tr|A0A3Q1N6D4-1|SFXN1_BOVIN Computationally mapped isoform of Sideroflexin-1 OS=Bos taurus OX=9913 GN=SFXN1 PE=2 SV=1 CANONICAL=Q5E9M8-1" }, "locus": { "chromosome": "10", "start_pos": 5658778, "end_pos": 5615344, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083548.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083548.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066005.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066005.1" } ] } }, { "isoform_ac": "A0A3Q1NB55-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9M8/entry#A0A3Q1NB55-1", "sequence": { "sequence": "MIVNGRTFCLRLKSRKMSGELPPNINIKEPRWDQSTFIGRAKHFFTVTDPRNILLTNEQLEAARKVVHDYRQGIIPSGLTENELWRAKYIYDSAFHPDTGEKMILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPVQVGIVGFCLVFATPLCCALFPQKSSMSVTSLEAELQARIRETYPELRRVYFNKGL", "length": 338, "header": "tr|A0A3Q1NB55-1|SFXN1_BOVIN Computationally mapped isoform of Sideroflexin-1 OS=Bos taurus OX=9913 GN=SFXN1 PE=2 SV=1 CANONICAL=Q5E9M8-1" }, "locus": { "chromosome": "10", "start_pos": 5673064, "end_pos": 5615344, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069486.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069486.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068533.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068533.1" } ] } }, { "isoform_ac": "A0AAA9TTA6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9M8/entry#A0AAA9TTA6-1", "sequence": { "sequence": "MPANLENSAVATGLEKSRKMSGELPPNINIKEPRWDQSTFIGRAKHFFTVTDPRNILLTNEQLEAARKVVHDYRQGIIPSGLTENELWRAKYIYDSAFHPDTGEKMILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPVQVGIVGFCLVFATPLCCALFPQKSSMSVTSLEAELQARIRETYPELRRVYFNKGL", "length": 341, "header": "tr|A0AAA9TTA6-1|SFXN1_BOVIN Computationally mapped isoform of Sideroflexin-1 OS=Bos taurus OX=9913 GN=SFXN1 PE=2 SV=1 CANONICAL=Q5E9M8-1" }, "locus": { "chromosome": "10", "start_pos": 5669274, "end_pos": 5615344, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131082.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131082.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101861.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101861.1" } ] } }, { "isoform_ac": "A0AAF6Z038-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9M8/entry#A0AAF6Z038-1", "sequence": { "sequence": "MSGELPPNINIKEPRWDQSTFIGRAKHFFTVTDPRNILLTNEQLEAARKVVHDYRQGIIPSGLTENELWRAKYIYDSAFHPDTGEKMILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAAPGMAIPPFIMNTLEKKAFLKRSLLRDQEVPMDECTCSSWNSWLLLGVCYASVLCSVSAEKFHVCDKLGGRAASQDPRDLP", "length": 318, "header": "tr|A0AAF6Z038-1|SFXN1_BOVIN Computationally mapped isoform of Sideroflexin-1 OS=Bos taurus OX=9913 GN=SFXN1 PE=2 SV=1 CANONICAL=Q5E9M8-1" }, "locus": { "chromosome": "10", "start_pos": 5658778, "end_pos": 5615378, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019322.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019322.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019322.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019322.5" } ] } }, { "isoform_ac": "A0ABI0NYP3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9M8/entry#A0ABI0NYP3-1", "sequence": { "sequence": "MSGELPPNINIKEPRWDQSTFIGRAKHFFTVTDPRNILLTNEQLEAARKVVHDYRQGIIPSGLTENELWRAKYIYDSAFHPDTGEKMILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAAPGMAIPPFIMNTLEKKAFLKALKERTCQMNLERGHQPYPPGCWEEVEHPVAP", "length": 290, "header": "tr|A0ABI0NYP3-1|A0ABI0NYP3_BOVIN Computationally mapped isoform of Sideroflexin-1 OS=Bos taurus OX=9913 GN=SFXN1 PE=1 SV=1 CANONICAL=Q5E9M8-1" }, "locus": { "chromosome": "10", "start_pos": 5658778, "end_pos": 5624941, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151353.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151353.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105453.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105453.1" } ] } }, { "isoform_ac": "Q5E9M8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9M8/entry#Q5E9M8-1", "sequence": { "sequence": "MSGELPPNINIKEPRWDQSTFIGRAKHFFTVTDPRNILLTNEQLEAARKVVHDYRQGIIPSGLTENELWRAKYIYDSAFHPDTGEKMILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPVQVGIVGFCLVFATPLCCALFPQKSSMSVTSLEAELQARIRETYPELRRVYFNKGL", "length": 322, "header": "sp|Q5E9M8-1|SFXN1_BOVIN Isoform 1 of Sideroflexin-1 OS=Bos taurus OX=9913 GN=SFXN1 PE=2 SV=3 CANONICAL=Q5E9M8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M8", "url": "https://www.uniprot.org/uniprotkb/Q5E9M8" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:511375", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511375", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2M6J0-1", "protein_name": "Sidoreflexin", "gene_name": "Sfxn1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSGEVPPNINIKEPRWDQSTFVGRANHFFTVTDPRNILLTNEQLENARKVVHDYRQGIIPAGLTENELWRAKYVYDSAFHPDTGEKMILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKRVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGTRLGESTNAAKQAITQVVISRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPIQVTLVGFCLVFATPLCCALFPQKSSMSVTSLEDELQASIQRSHPELRRVYFNKGL", "length": 322 }, "evidence": [ { "id": "Q5E9M8", "url": "https://omabrowser.org/oma/group/Q5E9M8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0Y876-1", "protein_name": "Sidoreflexin", "gene_name": "SFXN1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSADIPLNINIKEPRWDQSTFIGRASHFFTVTDPRNILLSDAQLENARKIVHDYRQGIVAPGLTENELWRAKYIYDSAFHPDTGEKMVLIGRMSAQVPMNMTITGCMMTFYRTTPAVVFWQWINQSFNAIVNYTNRSGDAPITVSQLGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKFGIPITDENGNRLGESTKAAQQAITQVVISRILMAAPGMAIPPFIMNTLEKRAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKRYVLFYVIFSLMLHFNACRILQRDTNKLSLPPRAYSLNIHII", "length": 332 }, "evidence": [ { "id": "Q5E9M8", "url": "https://omabrowser.org/oma/group/Q5E9M8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A5A761-1", "protein_name": "Sideroflexin-1", "gene_name": "SFXN1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGELPPNINIKEPRWDQSTFVGRANHFFTVTDPRNILLTNEQLENARKVVHDYRQGIVPPGLTENELWRAKYIYDSAFHPDTGEKMILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELRAGIPVTDENGNRLGESANAAKQAITQVVISRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKSSMSVTSLEAELQAKIRETSPELRRVYFNKGL", "length": 322 }, "evidence": [ { "id": "Q5E9M8", "url": "https://omabrowser.org/oma/group/Q5E9M8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1R5W5-1", "protein_name": "Sidoreflexin", "gene_name": "sfxn1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAATISTSINIKEPRWDQGTFVGRAKHFFTVTDPRNILLSNKQLEKAHQIIQDYKKGVVAADLTEDELWRAKYVFDSAFHPDTGEKMLLIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAIVNYTNRSGDAPITVNQLGTAYVSATTGAVATALGLNALAKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKHGIPVTDENDNRLGESSKAAQQAITQVVVSRILMASPGMAIPPFLMNSLEKKAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKSSMAVSRLEPELQEKIRASHPGVETVYFNKGL", "length": 322 }, "evidence": [ { "id": "Q5E9M8", "url": "https://omabrowser.org/oma/group/Q5E9M8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q12029-1", "protein_name": "Sideroflexin FSF1", "gene_name": "FSF1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MASSVPGPIDLPESRYDLSTYWGRIRHCAEISDPTMLLTTEKDLAHAREIISAYRHGELKETTPEFWRAKKQLDSTVHPDTGKTVLLPFRMSSNVLSNLVVTVGMLTPGLGTAGTVFWQWANQSLNVAVNSANANKSHPMSTSQLLTNYAAAVTASCGVALGLNNLVPRLKNISPHSKLILGRLVPFAAVVSAGIVNVFLMRGNEIRKGISVFDSNGDEVGKSKKAAFMAVGETALSRVINATPTMVIPPLILVRLQRGVLKGKSLGVQTLANLGLISVTMFSALPFALGIFPQRQAIHLNKLEPELHGKKDKDGKPIEKVYFNRGI", "length": 327 }, "evidence": [ { "id": "Q5E9M8", "url": "https://omabrowser.org/oma/group/Q5E9M8/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q63965-1", "protein_name": "Sideroflexin-1", "gene_name": "Sfxn1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGEVPPNINIKEPRWDQSTFIGRASHFFTVTDPKNILLTNEQLENARKVVHDYRQGIVPAGLTENELWRAKYAYDSAFHPDTGEKMTLIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGTRLGESTNAAKQAITQVVISRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPIQVTLVGFCLVFATPLCCALFPQKSSMSVTSLEDDLQASIQKSHPELRRVYFNKGL", "length": 322 }, "evidence": [ { "id": "Q5E9M8", "url": "https://omabrowser.org/oma/group/Q5E9M8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99JR1-1", "protein_name": "Sideroflexin-1", "gene_name": "Sfxn1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGEVPPNINIKEPRWDQSTFIGRASHFFTVTDPRNILLTNEQLENARKVVHDYRQGIVPAGLTENELWRAKYAYDSAFHPDTGEKMTLIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKRVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGTRLGESTNAAKQAITQVVISRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPIQVTLVGFCLVFATPLCCALFPQKSSMSVTSLEDELQASIQRTHPEIRRVYFNKGL", "length": 322 }, "evidence": [ { "id": "Q5E9M8", "url": "https://omabrowser.org/oma/group/Q5E9M8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H9B4-1", "protein_name": "Sideroflexin-1", "gene_name": "SFXN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGELPPNINIKEPRWDQSTFIGRANHFFTVTDPRNILLTNEQLESARKIVHDYRQGIVPPGLTENELWRAKYIYDSAFHPDTGEKMILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKSSMSVTSLEAELQAKIQESHPELRRVYFNKGL", "length": 322 }, "evidence": [ { "id": "Q5E9M8", "url": "https://omabrowser.org/oma/group/Q5E9M8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VN13-1", "protein_name": "Sideroflexin-1-3", "gene_name": "Sfxn1-3", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSPLPRVNIDEPKYDQNSYLGRAKHFFLLTNPLNVLASASKLEEARQIVIKYRAGKDVPECKTIDDVWRAKYLYDSAFHPETGEKQIVIGRMAAQMPMNTIITGGMMAFYKSTPAVVFWQWFNQTFNAIVNYTNRSGTSPISQQQLVTSYCLATSGALVTALSLNHAVKNMNPLLGRLVPLVAVGAANCINIPCMRMQELRNGVTLFDEHSNEMGISKKAAVVGISTVILSRIAMAIPGMTLTPVLMNVLEKRGFLAKYPRSNAPIQTLFCGFVLIFATPLGCAFFKQRADIKVDSLESEVRDSIRKKRPELETVWFNKGL", "length": 321 }, "evidence": [ { "id": "Q5E9M8", "url": "https://omabrowser.org/oma/group/Q5E9M8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "L-alanine transmembrane transporter activity", "id": "GO:0015180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015180", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M8", "url": "https://www.uniprot.org/uniprotkb/Q5E9M8" } ], "pmid": "" }, { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M8", "url": "https://www.uniprot.org/uniprotkb/Q5E9M8" } ], "pmid": "" }, { "name": "L-serine transmembrane transporter activity", "id": "GO:0015194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015194", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M8", "url": "https://www.uniprot.org/uniprotkb/Q5E9M8" } ], "pmid": "" }, { "name": "monoatomic ion transmembrane transporter activity", "id": "GO:0015075", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015075", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M8", "url": "https://www.uniprot.org/uniprotkb/Q5E9M8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "L-serine transport", "id": "GO:0015825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015825", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M8", "url": "https://www.uniprot.org/uniprotkb/Q5E9M8" } ], "pmid": "" }, { "name": "one-carbon metabolic process", "id": "GO:0006730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006730", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M8", "url": "https://www.uniprot.org/uniprotkb/Q5E9M8" } ], "pmid": "" }, { "name": "L-alanine transport", "id": "GO:0015808", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015808", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M8", "url": "https://www.uniprot.org/uniprotkb/Q5E9M8" } ], "pmid": "" }, { "name": "serine import into mitochondrion", "id": "GO:0140300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140300", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M8", "url": "https://www.uniprot.org/uniprotkb/Q5E9M8" } ], 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{ "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" }, { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29655", "name": "", "equation": "L-cysteine(in) = L-cysteine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "29655", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29655" } ] }, { "id": "35031", "name": "", "equation": "L-serine(in) = L-serine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "35031", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/35031" } ] }, { "id": "70719", "name": "", "equation": "L-alanine(in) = L-alanine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": 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Beuren syndrome chromosome region 22 protein", "type": "synonym", "evidence": [ { "id": "NP_001029629", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029629" } ] }, { "name": "Williams-Beuren syndrome chromosomal region 22 protein homolog", "type": "synonym", "evidence": [ { "id": "NP_001029629", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029629" }, { "id": "Q58DP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DP0/entry#names_and_taxonomy" } ] }, { "name": "Williams-Beuren syndrome chromosome region 22", "type": "synonym", "evidence": [ { "id": "NP_001029629", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029629" } ] }, { "name": "bud site selection protein 23 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029629", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029629" } ] }, { "name": "probable 18S rRNA (guanine-N(7))-methyltransferase", "type": "synonym", "evidence": [ { "id": "NP_001029629", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029629" } ] }, { "name": "rRNA methyltransferase and ribosome maturation factor", "type": "synonym", "evidence": [ { "id": "NP_001029629", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029629" }, { "id": "Q58DP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DP0/entry#names_and_taxonomy" } ] }, { "name": "ribosome biogenesis methyltransferase WBSCR22", "type": "synonym", "evidence": [ { "id": "NP_001029629", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029629" } ] } ], "function": [ { "annotation": "S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. 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"MAFRGRRPELRGPPELYYDKNEARKYVRNSRMIDVQIKMTGRALELLCVPEDKPCYVLDIGCGTGLSGDYLSDEGHYWVGIDISPAMLDEALDRETQGDVILGDMGQGIPFKPGTFDACISISAVQWLCNANKKSDIPAKRLYCFFSSLYSVLVRGGRAVLQLYPENSEQLELITTQATRAGFTGGVVVDYPNSAKAKKFYLCLFSGPSTSLPEGLSEDTEEEKPAESTFTADRIPYRIARRGVVRKSREWVLEKKARRRRQGKEVCPDTQYTGRKRKPRF", "length": 281, "header": "sp|Q58DP0-1|BUD23_BOVIN Isoform 1 of 18S rRNA (guanine-N(7))-methyltransferase OS=Bos taurus OX=9913 GN=BUD23 PE=2 SV=1 CANONICAL=Q58DP0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NA41-1", "url": "https://www.uniprot.org/uniprotkb/Q58DP0/entry#A0A3Q1NA41-1", "sequence": { "sequence": "MAFRGRRPELRGPPELYYDKNEARKYVRNSRMIDVQIKMTGRALELLCVPEDKPCYVLDIGCGTGLSGDYLSDEGHYWVGIDISPAMLDEALDRETQGDVILGDMGQGIPFKAGTFDACISISAVQWLCNANKKSDIPAKRLYCFFSSLYSVLPAALPDSLPFSPQLELITTQATRAGFTGGVVVDYPNSAKKAPWSLQGLSEDTEEEKPAESTFTADRIPYRIARRGVVRKSREWVLEKKARRRRQGKEVCPDTQYTGRKRKPRF", "length": 266, "header": "tr|A0A3Q1NA41-1|BUD23_BOVIN Computationally mapped isoform of 18S rRNA (guanine-N(7))-methyltransferase OS=Bos taurus OX=9913 GN=BUD23 PE=2 SV=1 CANONICAL=Q58DP0-1" }, "locus": { "chromosome": "25", "start_pos": 33573419, "end_pos": 33562342, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077007.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077007.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068072.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068072.1" } ] } }, { "isoform_ac": "A0A452DIR9-1", "url": "https://www.uniprot.org/uniprotkb/Q58DP0/entry#A0A452DIR9-1", "sequence": { "sequence": "MAFRGRRPELRGPPELYYDKNEARKYVRNSRMIDVQIKMTGRALELLCVPEDKPCYVLDIGCGTGLSGDYLSDEGHYWVGIDISPAMLDEALDRETQGDVILGDMGQGIPFKAGTFDACISISAVQWLCNANKKSDIPAKRLYCFFSSLYSVLVRGGRAVLQLYPENSEQLELITTQATRAGFTGGVVVDYPNSAKAKKFYLCLFSGPSTSLPEGLSEDTEEEKPAESTFTADRIPYRIARRGVVRKSREWVLEKKARRRRQGKEVCPDTQYTGRKRKPRF", "length": 281, "header": "tr|A0A452DIR9-1|BUD23_BOVIN Computationally mapped isoform of 18S rRNA (guanine-N(7))-methyltransferase OS=Bos taurus OX=9913 GN=BUD23 PE=2 SV=1 CANONICAL=Q58DP0-1" }, "locus": { "chromosome": "25", "start_pos": 33573419, "end_pos": 33562342, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022697.4", "url": "https://www.ensembl.org/id/ENSBTAT00000022697.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022697.4", "url": "https://www.ensembl.org/id/ENSBTAP00000022697.4" } ] } }, { "isoform_ac": "A0AAA9SYE4-1", "url": "https://www.uniprot.org/uniprotkb/Q58DP0/entry#A0AAA9SYE4-1", "sequence": { "sequence": "MAFRGRRPELRGPPELYYDKNEARKYVRNSRMIDVQIKMTGRALELLCVPEDKPCYVLDIGCGTGLSGDYLSDEGHYWVGIDISPAMLDEALDRETQGDVILGDMGQGIPFKAGTFDACISISAVQWLCNANKKSDIPAKRLYCFFSSLYSVLVRGGRAVLQLYPENSEQLELITTQATRAGFTGGVVVDYPNSAKAKKFYLCLFSGPSTSLPEGLSEDTEEEKPAESTFTADRYPALAPSKRSHLLLHREIQVV", "length": 255, "header": "tr|A0AAA9SYE4-1|BUD23_BOVIN Computationally mapped isoform of 18S rRNA (guanine-N(7))-methyltransferase OS=Bos taurus OX=9913 GN=BUD23 PE=2 SV=1 CANONICAL=Q58DP0-1" }, "locus": { "chromosome": "25", "start_pos": 33573419, "end_pos": 33565069, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109280.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109280.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089112.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089112.1" } ] } }, { "isoform_ac": "Q58DP0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DP0/entry#Q58DP0-1", "sequence": { "sequence": "MAFRGRRPELRGPPELYYDKNEARKYVRNSRMIDVQIKMTGRALELLCVPEDKPCYVLDIGCGTGLSGDYLSDEGHYWVGIDISPAMLDEALDRETQGDVILGDMGQGIPFKPGTFDACISISAVQWLCNANKKSDIPAKRLYCFFSSLYSVLVRGGRAVLQLYPENSEQLELITTQATRAGFTGGVVVDYPNSAKAKKFYLCLFSGPSTSLPEGLSEDTEEEKPAESTFTADRIPYRIARRGVVRKSREWVLEKKARRRRQGKEVCPDTQYTGRKRKPRF", "length": 281, "header": "sp|Q58DP0-1|BUD23_BOVIN Isoform 1 of 18S rRNA (guanine-N(7))-methyltransferase OS=Bos taurus OX=9913 GN=BUD23 PE=2 SV=1 CANONICAL=Q58DP0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DP0", "url": "https://www.uniprot.org/uniprotkb/Q58DP0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:513878", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513878", "resource": "KEGG Pathway" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2M7W3-1", "protein_name": "18S rRNA (guanine-N(7))-methyltransferase", "gene_name": "Bud23", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASRSRRPEHSGPPELFYDQNEARKYVRNSRMIDIQTKMTERALELLCLPEGQPSFLLDIGCGSGLSGDYISEEGHYWVGIDISPAMLDAALDRDTEGDLLLGDMGQGIPFRPGSFDGCISISAVQWLCNANKKSDVPARRLYCFFSSLYSALVHGARAVLQLYPENSEQLELITTQATRAGFTGGVVVDFPNSAKAKKFYLCLFSGPSTSLPKGLTESQDADQATELTFTSERAPHKKARRDLVKKSREWVLEKKERRRRQGKEVRPDTQYTGRKRKPRF", "length": 281 }, "evidence": [ { "id": "Q58DP0", "url": "https://omabrowser.org/oma/group/Q58DP0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V1AMG4-1", "protein_name": "18S rRNA (guanine-N(7))-methyltransferase", "gene_name": "WBSCR22", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASSGRRPEHRGPPELFYDETEARKYTQNSRVAEIQAQMAARAVELLALPEGRPCLLLDVGCGSGLSGEHISEEGHCWIGVDISRAMLDVAVEREVEGDLLLADMGDGIPFRPGTFDGCIRRCTFSISAVQWLCNADKKSHSPPKRLYWFFSTLYTALARGSRAVLQLYPENSEQLELITAQAMRAGFTGGMVIDYPNSAKAKKFFLCLFVGASGTLPKGLGTECADGEEIHQAKFTQERIRFRNAKGKSVKKSRDWILEKKERRRRQGKEVRADTKYTGRKRRPQF", "length": 287 }, "evidence": [ { "id": "Q58DP0", "url": "https://omabrowser.org/oma/group/Q58DP0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O43709-1", "protein_name": "18S rRNA (guanine-N(7))-methyltransferase", "gene_name": "BUD23", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASRGRRPEHGGPPELFYDETEARKYVRNSRMIDIQTRMAGRALELLYLPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEGDLLLGDMGQGIPFKPGTFDGCISISAVQWLCNANKKSENPAKRLYCFFASLFSVLVRGSRAVLQLYPENSEQLELITTQATKAGFSGGMVVDYPNSAKAKKFYLCLFSGPSTFIPEGLSENQDEVEPRESVFTNERFPLRMSRRGMVRKSRAWVLEKKERHRRQGREVRPDTQYTGRKRKPRF", "length": 281 }, "evidence": [ { "id": "Q58DP0", "url": "https://omabrowser.org/oma/group/Q58DP0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P25627-1", "protein_name": "18S rRNA (guanine(1575)-N(7))-methyltransferase", "gene_name": "BUD23", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSRPEELAPPEIFYNDSEAHKYTGSTRVQHIQAKMTLRALELLNLQPCSFILDIGCGSGLSGEILTQEGDHVWCGLDISPSMLATGLSRELEGDLMLQDMGTGIPFRAGSFDAAISISAIQWLCNADTSYNDPKQRLMRFFNTLYAALKKGGKFVAQFYPKNDDQVDDILQSAKVAGFSGGLVVDDPESKKNKKYYLVLSSGAPPQGEEQVNLDGVTMDEENVNLKKQLRQRLKGGKDKESAKSFILRKKELMKRRGRKVAKDSKFTGRKRRHRF", "length": 275 }, "evidence": [ { "id": "Q58DP0", "url": "https://omabrowser.org/oma/group/Q58DP0/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q55DA6-1", "protein_name": "Probable 18S rRNA (guanine-N(7))-methyltransferase", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSRPEHIAPPEIFYDDVESKKYSSNSRIIEIQTKMAERAYELLAIPETAEGLMLLDIGCGSGISGDVITDAGHYWIGCDISQHMLDVAIDREVEGDVMLRDIGQGFPFRAGSFDAAISISAIQWLCNAEKSHHNPRKRLHTFFQSLFNVLTRGGKAILQFYPENSAQIEMITASALRCGFSGGLLIDFPNSSKAKKYFLVLFTGNNNIMPSAKGVEGEEYEQQEEEDSNEVKYSNRKRDRRRVTKSKGSAQHKTKEWIMNKKDRQRKQGREIKNDSKFSGRKRGPKF", "length": 287 }, "evidence": [ { "id": "Q58DP0", "url": "https://omabrowser.org/oma/group/Q58DP0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9CY21-1", "protein_name": "18S rRNA (guanine-N(7))-methyltransferase", "gene_name": "Bud23", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASRSRRPEHSGPPELFYDQNEARKYVRNSRMIDIQTKMTERALELLCLPEGQPSYLLDIGCGSGLSGDYISEEGHYWVGIDISPAMLDAALDRDTEGDLLLGDMGQGVPFRPGSFDGCISISAVQWLCNANKKSDVPARRLYCFFSSLYSALVRGARAVLQLYPENSEQLELITTQATRAGFTGGVVVDFPNSAKAKKFYLCLFSGPSTSLPKGLTESQDADQASESMFTSERAPHKKARRDLVKKSREWVLEKKERRRRQGKEVRPDTQYTGRKRKPRF", "length": 281 }, "evidence": [ { "id": "Q58DP0", "url": "https://omabrowser.org/oma/group/Q58DP0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9LVD0-1", "protein_name": "18S rRNA (guanine-N(7))-methyltransferase RID2", "gene_name": "RID2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSNRPELLAPPEIFYDDTEARKYTSSSRIVEIQAKLSERALELLALPEDGVPRFLLDIGCGSGLSGETLSEDGHHWIGLDISASMLHVAVEREVEGDLLLGDMGQGLGLRSGVIDGAISISAVQWLCNADKSSHEPRLRLKAFFGSLYRCLSRGARAVFQVYPENIAQRELILRQALQAGFGGGLVVDYPHSTKKRKEFLVLTCGTVQTSIQTSKNEYDESCSEDDNSDDEESEEVGVSDRNRPRKRQRTNTKVKGREWVLRKKEQSRRKGKNVPADSKFTSRKRRTRF", "length": 289 }, "evidence": [ { "id": "Q58DP0", "url": "https://omabrowser.org/oma/group/Q58DP0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VHW6-1", "protein_name": "18S rRNA (guanine-N(7))-methyltransferase", "gene_name": "Dmel\\CG10903", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MARRPEHSAPPEIFYNDDEAKKYSTNTRIIEIQVEMAERALELLALPDDDESRLILDIGCGSGLSGSVLEDSEHMWIGIDISKSMLDIAVEREVAGDVILGDMGEGMPFKPGTFDGAISISALQWLCNADKSYHNPHKRLLKFFTTLFSCLTRTARAVFQFYPENSDQIEMVTSQAMKAGFYGGLVVDYPNSAKAKKYYLVLMTGGSAELPQALGSPEEERRVNYIKKRDACREARGKAPKKSRDWILAKKERRRRQGLETRPDTKYTARKRSGKF", "length": 276 }, "evidence": [ { "id": "Q58DP0", "url": "https://omabrowser.org/oma/group/Q58DP0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "rRNA (guanine) methyltransferase activity", "id": "GO:0016435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016435", "evidence": [ { "database": "UniProtKB", "id": "Q58DP0", "url": "https://www.uniprot.org/uniprotkb/Q58DP0" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "Q58DP0", "url": "https://www.uniprot.org/uniprotkb/Q58DP0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "rRNA (guanine-N7)-methylation", "id": "GO:0070476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070476", "evidence": [ { "database": "UniProtKB", "id": "Q58DP0", "url": "https://www.uniprot.org/uniprotkb/Q58DP0" } ], "pmid": "" }, { "name": "positive regulation of rRNA processing", "id": "GO:2000234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000234", "evidence": [ { "database": "UniProtKB", "id": "Q58DP0", "url": "https://www.uniprot.org/uniprotkb/Q58DP0" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q58DP0", "url": "https://www.uniprot.org/uniprotkb/Q58DP0" } ], "pmid": "" }, { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "Q58DP0", "url": "https://www.uniprot.org/uniprotkb/Q58DP0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q58DP0", "url": "https://www.uniprot.org/uniprotkb/Q58DP0" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q58DP0", "url": "https://www.uniprot.org/uniprotkb/Q58DP0" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "Q58DP0", "url": "https://www.uniprot.org/uniprotkb/Q58DP0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58DP0", "url": "https://www.uniprot.org/uniprotkb/Q58DP0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "54584", "name": "", "equation": "a guanosine in 18S rRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q58DP0-1" ], "evidence": [ { "id": "54584", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/54584" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q58DP0", "gene_name": "BUD23", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q58DP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DP0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DP0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 281, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DP0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DP0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5I597-1", "uniprot_ac": "Q5I597", "uniprot_id": "BHMT1_BOVIN", "mass": { "chemical_mass": 44878.0, "monoisotopic_mass": 44878.0 }, "refseq": { "ac": "NP_001011679", "name": "betaine--homocysteine S-methyltransferase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011679" }, "gene_names": [ { "name": "BHMT", "type": "recommended", "evidence": [ { "id": "Q5I597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5I597" } ] }, { "name": "BHMT", "type": "synonym", "evidence": [ { "id": "NP_001011679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011679" } ] } ], "protein_names": [ { "name": "Betaine--homocysteine S-methyltransferase 1", "type": "recommended", "evidence": [ { "id": "Q5I597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5I597/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.5", "type": "synonym", "evidence": [ { "id": "Q5I597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5I597/entry#names_and_taxonomy" } ] }, { "name": "betaine--homocysteine S-methyltransferase 1", "type": "synonym", "evidence": [ { "id": "NP_001011679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011679" } ] }, { "name": "betaine-homocysteine methyltransferase", "type": "synonym", "evidence": [ { "id": "NP_001011679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011679" } ] } ], "function": [ { "annotation": "Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NDS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDS5#function" }, { "database": "UniProtKB", "id": "ARBA00037521", "url": "https://www.uniprot.org/uniprotkb/ARBA00037521#function" }, { "database": "UniProtKB", "id": "Q5I597", "url": "https://www.uniprot.org/uniprotkb/Q5I597#function" }, { "database": "UniProtKB", "id": "Q93088", "url": "https://www.uniprot.org/uniprotkb/Q93088#function" } ] }, { "annotation": "These findings indicate that greater synthesis of phosphatidylcholine and antioxidants contribute to the better performance and immuno-metabolic status in methionine-supplemented cows.", "evidence": [ { "database": "RefSeq", "id": "NP_001011679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011679" }, { "database": "PubMed", "id": "27881594", "url": "https://glygen.org/publication/PubMed/27881594" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5I597", "url": "https://www.uniprot.org/uniprotkb/Q5I597" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BHMT", "url": "https://www.uniprot.org/uniprotkb/Q5I597", "locus": { "chromosome": "10", "start_pos": 10214793, "end_pos": 10191696, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002255", "url": "https://www.ensembl.org/id/ENSBTAG00000002255" } ] } } ], "crossref": [ { "id": "Q5I597", "url": "https://alphafold.ebi.ac.uk/entry/Q5I597", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002255", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002255", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "497025", "url": "https://www.ncbi.nlm.nih.gov/gene/497025", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003726", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003726", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017226", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017226", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036589", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036589", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051524", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051524", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:497025", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:497025", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CKDKTEV", "url": "https://omabrowser.org/oma/group/CKDKTEV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NDS5", "url": "https://www.orthodb.org/?gene=A0A3Q1NDS5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DHV7", "url": "https://www.orthodb.org/?gene=A0A452DHV7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5I597", "url": "https://www.orthodb.org/?gene=Q5I597", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46120", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46120", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46120:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46120:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02574", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02574", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1614635", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1614635", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6798163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001011679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011679", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "22336", "url": "https://www.rhea-db.org/rhea/22336", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NDS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDS5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NDS5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDS5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DHV7", "url": "https://www.uniprot.org/uniprotkb/A0A452DHV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DHV7-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DHV7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5I597", "url": "https://www.uniprot.org/uniprotkb/Q5I597", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5I597-1", "url": "https://www.uniprot.org/uniprotkb/Q5I597-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPAGGKNVKKGILERLNSGEVIIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVAEKISGQKVNEAACDIARQVADEGDALVAGGVSQTPSYLSCKSETEVKKVFQQQLEVFVKKNVDFLIAEYFEHVEEAVWAVEALKASGKPVAATMCIGPEGDLHSVTPGECAVRLVKAGASIVGVNCHFDPTISLQTVKLMKEGLEAAGLKAHLMSQPLAYHTPDCGKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPLASEKHGSWGSGLDMHTKPWIRARARKEYWENLQIASGRPYNPSMSKPDAWGVTKGTAELMQQKEATTEQQLRELFEKQKFKSAQ", "length": 407, "header": "sp|Q5I597-1|BHMT1_BOVIN Isoform 1 of Betaine--homocysteine S-methyltransferase 1 OS=Bos taurus OX=9913 GN=BHMT PE=2 SV=1 CANONICAL=Q5I597-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NDS5-1", "url": "https://www.uniprot.org/uniprotkb/Q5I597/entry#A0A3Q1NDS5-1", "sequence": { "sequence": "MAPAGGKNVKKGILERLNSGEVIIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAGASIVGVNCHFDPTISLQTVKLMKEGLEAAGLKAHLMSQPLAYHTPDCGKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPLASEKHGSWGSGLDMHTKPWIRARARKEYWENLQIASGRPYNPSMSKPDAWGVTKGTAELMQQKEATTEQQLRELFEKQKFKSAQ", "length": 254, "header": "tr|A0A3Q1NDS5-1|BHMT1_BOVIN Computationally mapped isoform of Betaine--homocysteine S-methyltransferase 1 OS=Bos taurus OX=9913 GN=BHMT PE=2 SV=2 CANONICAL=Q5I597-1" }, "locus": { "chromosome": "10", "start_pos": 10214232, "end_pos": 10192288, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085352.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085352.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069661.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069661.2" } ] } }, { "isoform_ac": "A0A452DHV7-1", "url": "https://www.uniprot.org/uniprotkb/Q5I597/entry#A0A452DHV7-1", "sequence": { "sequence": "MIPGKGEIQFVDLRGEKKGRAQIGLKPERVATSLFNYIFLILLLDNFPHLGEQFRSPTPNTSSQAATGKDKGLVGVFPAQGPCWTAQRLGKQTHTRSNGYKEPGHGSRLRRGKRSPRPSSSVLGAVRDTRKMAPAGGKNVKKGILERLNSGEVIIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVAEKISGQKVNEAACDIARQVADEGDALVAGGVSQTPSYLSCKSETEVKKVFQQQLEVFVKKNVDFLIAEYFEHVEEAVWAVEALKASGKPVAATMCIGPEGDLHSVTPGECAVRLVKAGASIVGVNCHFDPTISLQTVKLMKEGLEAAGLKAHLMSQPLAYHTPDCGKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPLASEKHGSWGSGLDMHTKPWIRARARKEYWENLQIASGRPYNPSMSKPDAWGVTKGTAELMQQKEATTEQQLRELFEKQKFKSAQ", "length": 538, "header": "tr|A0A452DHV7-1|BHMT1_BOVIN Computationally mapped isoform of Betaine--homocysteine S-methyltransferase 1 OS=Bos taurus OX=9913 GN=BHMT PE=2 SV=1 CANONICAL=Q5I597-1" }, "locus": { "chromosome": "10", "start_pos": 10214232, "end_pos": 10191895, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002916.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002916.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002916.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002916.5" } ] } }, { "isoform_ac": "Q5I597-1", "url": "https://www.uniprot.org/uniprotkb/Q5I597/entry#Q5I597-1", "sequence": { "sequence": "MAPAGGKNVKKGILERLNSGEVIIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVAEKISGQKVNEAACDIARQVADEGDALVAGGVSQTPSYLSCKSETEVKKVFQQQLEVFVKKNVDFLIAEYFEHVEEAVWAVEALKASGKPVAATMCIGPEGDLHSVTPGECAVRLVKAGASIVGVNCHFDPTISLQTVKLMKEGLEAAGLKAHLMSQPLAYHTPDCGKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPLASEKHGSWGSGLDMHTKPWIRARARKEYWENLQIASGRPYNPSMSKPDAWGVTKGTAELMQQKEATTEQQLRELFEKQKFKSAQ", "length": 407, "header": "sp|Q5I597-1|BHMT1_BOVIN Isoform 1 of Betaine--homocysteine S-methyltransferase 1 OS=Bos taurus OX=9913 GN=BHMT PE=2 SV=1 CANONICAL=Q5I597-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 197, "start_aa": "Thr", "end_pos": 197, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr197", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 330, "end_pos": 330, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5I597", "url": "https://www.uniprot.org/uniprotkb/Q5I597" } ], "site_lbl": "Ser330" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Hepatic Activity and Transcription of Betaine-Homocysteine Methyltransferase, Methionine Synthase, and Cystathionine Synthase in Periparturient Dairy Cows Are Altered to Different Extents by Supply of Methionine and Choline.", "journal": "The Journal of nutrition", "date": "2017-01", "authors": "Zhou Zheng, Garrow Timothy A, Dong Xianwen, Luchini Daniel N, Loor Juan J", "evidence": [ { "database": "RefSeq", "id": "NP_001011679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011679" } ], "reference": [ { "type": "PubMed", "id": "27881594", "url": "https://glygen.org/publication/PubMed/27881594" } ] } ], "pathway": [ { "id": "bta:497025", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:497025", "resource": "KEGG Pathway" }, { "id": "R-BTA-1614635", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1614635", "resource": "Reactome", "description": "Sulfur amino acid metabolism" }, { "id": "R-BTA-6798163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798163", "resource": "Reactome", "description": "Choline catabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "G3H309-1", "protein_name": "Betaine--homocysteine S-methyltransferase 1", "gene_name": "Bhmt", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAPVAGKKAKKGILERLNAGEVVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVAEKISGQKVNEAACDIARQVADEGDALVAGGVSQTPSYLSCKSEMEVKKIFQQQLEVFMKKNVDFLIAEYFEHVEEAVWAVEALKTSGKPIAATMCIGPEGDLHGVSPGECAVRLVKAGASIVGVNCHFDPATSLQTVKLMKEGLEGARLKAYLMTQPLAYHTPDCSKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARKEYWQNLRIASGRPYNPSMSKPDAWGVTKGTSELMQQKEATTEQQLKELFEKQKFKSAQ", "length": 407 }, "evidence": [ { "id": "Q5I597", "url": "https://omabrowser.org/oma/group/Q5I597/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O09171-1", "protein_name": "Betaine--homocysteine S-methyltransferase 1", "gene_name": "Bhmt", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAPIAGKKAKRGILERLNAGEVVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVAEKISGQKVNEAACDIARQVADEGDALVAGGVSQTPSYLSCKSETEVKKIFHQQLEVFMKKNVDFLIAEYFEHVEEAVWAVEALKTSGKPIAATMCIGPEGDLHGVSPGECAVRLVKAGAAIVGVNCHFDPSTSLQTIKLMKEGLEAARLKAYLMSHALAYHTPDCGKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARKEYWQNLRIASGRPYNPSMSKPDAWGVTKGAAELMQQKEATTEQQLRALFEKQKFKSAQ", "length": 407 }, "evidence": [ { "id": "Q5I597", "url": "https://omabrowser.org/oma/group/Q5I597/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O35490-1", "protein_name": "Betaine--homocysteine S-methyltransferase 1", "gene_name": "Bhmt", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPVAGKKAKKGILERLNAGEVVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVAEKISGQKVNEAACDIARQVADEGDALVAGGVSQTPSYLSCKSEVEVKKIFRQQLEVFMKKNVDFLIAEYFEHVEEAVWAVEALKASGKPVAATMCIGPEGDLHGVPPGECAVRLVKAGASIVGVNCHFDPSVSLQTVKLMKEGLEAARLKAYLMSQPLAYHTPDCGKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARKEYWQNLRIASGRPYNPSMSRPDAWGVTKGAAELMQQKEATTEQQLRELFEKQKFKSAQ", "length": 407 }, "evidence": [ { "id": "Q5I597", "url": "https://omabrowser.org/oma/group/Q5I597/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q93088-1", "protein_name": "Betaine--homocysteine S-methyltransferase 1", "gene_name": "BHMT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPPVGGKKAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIARQVADEGDALVAGGVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKPVAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARLKAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASGRPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFEKQKFKSQ", "length": 406 }, "evidence": [ { "id": "Q5I597", "url": "https://omabrowser.org/oma/group/Q5I597/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5I597", "url": "https://www.uniprot.org/uniprotkb/Q5I597" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5I597", "url": "https://www.uniprot.org/uniprotkb/Q5I597" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "Q5I597", "url": "https://www.uniprot.org/uniprotkb/Q5I597" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q5I597", "url": "https://www.uniprot.org/uniprotkb/Q5I597" } ], "pmid": "" }, { "name": "betaine-homocysteine S-methyltransferase activity", "id": "GO:0047150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047150", "evidence": [ { "database": "UniProtKB", "id": "Q5I597", "url": "https://www.uniprot.org/uniprotkb/Q5I597" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "Q5I597", "url": "https://www.uniprot.org/uniprotkb/Q5I597" } ], "pmid": "" }, { "name": "amino-acid betaine catabolic process", "id": "GO:0006579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006579", "evidence": [ { "database": "UniProtKB", "id": "Q5I597", "url": "https://www.uniprot.org/uniprotkb/Q5I597" } ], "pmid": "" }, { "name": "L-methionine salvage", "id": "GO:0071267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071267", "evidence": [ { "database": "UniProtKB", "id": "Q5I597", "url": "https://www.uniprot.org/uniprotkb/Q5I597" } ], "pmid": "" }, { "name": "methionine biosynthetic process", "id": "GO:0009086", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009086", "evidence": [ { "database": "UniProtKB", "id": "Q5I597", "url": "https://www.uniprot.org/uniprotkb/Q5I597" } ], "pmid": "" }, { "name": "amino-acid betaine metabolic 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"https://www.uniprot.org/uniprotkb/Q5I597" } ] }, { "ec_number": "2.1.1.5", "activity": "", "evidence": [ { "id": "Q5I597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5I597" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5I597-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 407, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5I597-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5I597" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5I597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5I597" }, { "id": "PRU00333", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00333" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Hcy-binding", "eco_id": "ECO_0000255", "start_pos": 11, "end_pos": 314, "start_aa": "Lys", "end_aa": "Leu", "glycosite_overlap": "" } ], 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"Protein" ] }, { "id": "Q3ZBK7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSEGRCWETLQALRSCDKGRLCYDRDWLLRGEDVLQECMSLPKLSSYSGWVVDHVLPHIQKNAPPSETSASSVSTSALDQPSSVPRSPLRNPAYSPVSSATSNGTKDKYESPHTEPVVLQSPRGMKVEGCIRMYELVHRMKGAEGLRQWQEEQEKKVRALSEMASEQLKRFDERKELKHHKEFQDLREVMEKSSREALGQQEKLKAEHRHRAKILNLKLREAEQQRLKQEEQERLRKEEGQARLRGLYALQEEVLHLSQQLDASDQHRDLLQVDLSAFRTRGNQLCSLVSGIIRATSENGFPTVEDQAAAEGALQEMRDLLSNLHQEIRRACEEKRRRDEEEARIKQQESQMQQRPEAHKELPVPNQGPGAKPNEDLQMKVQDSTMQWYQQLQEASSRCVLAFEGLSNSKDSQAKKIKMDLQKAATIPVSQISTIAGSKLKEIFDKIHSLLSGKPVQSGGRSVSVTLNPQGLDFVQYKLAEKFVKQGEEEVASHHEAAFPIAVVASGIWELHPRVGALILAHLHKKCPYSVPFYPAFKEGMALEDYQRMLGYQVKDSKVEQQDNFLKRMSGMIRLYAAIIQLRWPYGNRQETHPHGLNHGWRWLAQILNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMILLIKEDYFPRIEAITSSGQMGSFIRLKQFLEKCLQHREVPVPKGFLTASFWRS", "length": 698, "header": "sp|Q3ZBK7-1|GLE1_BOVIN Isoform 1 of mRNA export factor GLE1 OS=Bos taurus OX=9913 GN=GLE1 PE=2 SV=1 CANONICAL=Q3ZBK7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NF93-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7/entry#A0A3Q1NF93-1", "sequence": { "sequence": "MPSEGRCWETLQALRSCDKGRLCYDRDWLLRGEDVLQECMSLPKLSSYSGWVVDHVLPHIQKNAPPSETSASSVSTSALDQPSSVPRSPLRNPAYSPVSSATSNGTKDKYESPHTEPVVLQSPRGMKVEGCIRMYELVHRMKGAEGLRQWQEEQEKKVRALSEMASEQLKRFDERKELKHHKEFQDLREVMEKSSREALGQQEKLKAEHRHRAKILNLKLREAEQQRLKQEEQERLRKEEGQARLRGLYALQEEVLHLSQQLDASDQHRDLLQVDLSAFRTRGNQLCSLVSGIIRATSENGFPTVEDQAAAEGALQEMRDLLSNLHQEIRRACEEKRRRDEEEARIKQQESQMQQRPEAHKELPVPNQGPGAKPNEDLQMKVQDSTMQWYQQLQEASSRCVLAFEGLSNSKDSQAKKIKMDLQKAATIPVSQISTIAGSKLKEIFDKIHSLLSGKPVQSGGRSVSVTLNPQGLDFVQYKLAEKFVKQGEEEVASHHEAAFPIAVVASGIWELHPRVGALILAHLHKKCPYSVPFYPAFKEGMALEDYQRMLGYQVKDSKVEQQDNFLKRMSGMIRLYAAIIQLRWPYGNRQEVCGNALMKQYQVQFWKMILLIKEDYFPRIEAITSSGQMGSFIRLKQFLEKCLQHREVPVPKGFLTASFWRS", "length": 663, "header": "tr|A0A3Q1NF93-1|GLE1_BOVIN Computationally mapped isoform of mRNA export factor GLE1 OS=Bos taurus OX=9913 GN=GLE1 PE=2 SV=3 CANONICAL=Q3ZBK7-1" }, "locus": { "chromosome": "11", "start_pos": 99091100, "end_pos": 99065824, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070346.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070346.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070360.3", "url": "https://www.ensembl.org/id/ENSBTAP00000070360.3" } ] } }, { "isoform_ac": "A0AAA9RWR5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7/entry#A0AAA9RWR5-1", "sequence": { "sequence": "MPSEGRCWETLQALRSCDKGRLCYDRDWLLRGEDVLQECMSLPKLSSYSGWVVDHVLPHIQKNAPPSETSASSVSTSALDQPSSVPRSPLRNPAYSPVSSATSNGTKDKYESPHTEPVVLQSPRGMKVEGCIRMYELVHRMKGAEGLRQWQEEQEKKVRALSEMASEQLKRFDERKELKHHKEFQDLREVMEKSSREALGQQEKLKAEHRHRAKILNLKLREAEQQRLKQEEQERLRKEEGQARLRGLYALQEEVLHLSQQLDASDQHRDLLQVDLSAFRTRGNQLCSLVSGIIRATSENGFPTVEDQAAAEGALQEMRDLLSNLHQEIRRACEEKRRRDEEEARIKQQESQMQQRPEAHKELPVPNQGPGAKPNEDLQMKVQDSTMQWYQQLQEASSRCVLAFEGLSNSKDSQKQGEEEVASHHEAAFPIAVVASGIWELHPRVGALILAHLHKKCPYSVPFYPAFKEGMALEDYQRMLGYQVKDSKVEQQDNFLKRMSGMIRLYAAIIQLRWPYGNRQETHPHGLNHGWRWLAQILNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMILLIKEDYFPRIEAITSSGQMGSFIRLKQFLEKCLQHREVPVPKGFLTASFWRS", "length": 627, "header": "tr|A0AAA9RWR5-1|GLE1_BOVIN Computationally mapped isoform of mRNA export factor GLE1 OS=Bos taurus OX=9913 GN=GLE1 PE=2 SV=1 CANONICAL=Q3ZBK7-1" }, "locus": { "chromosome": "11", "start_pos": 99091100, "end_pos": 99065824, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095063.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095063.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076913.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076913.1" } ] } }, { "isoform_ac": "Q3ZBK7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7/entry#Q3ZBK7-1", "sequence": { "sequence": "MPSEGRCWETLQALRSCDKGRLCYDRDWLLRGEDVLQECMSLPKLSSYSGWVVDHVLPHIQKNAPPSETSASSVSTSALDQPSSVPRSPLRNPAYSPVSSATSNGTKDKYESPHTEPVVLQSPRGMKVEGCIRMYELVHRMKGAEGLRQWQEEQEKKVRALSEMASEQLKRFDERKELKHHKEFQDLREVMEKSSREALGQQEKLKAEHRHRAKILNLKLREAEQQRLKQEEQERLRKEEGQARLRGLYALQEEVLHLSQQLDASDQHRDLLQVDLSAFRTRGNQLCSLVSGIIRATSENGFPTVEDQAAAEGALQEMRDLLSNLHQEIRRACEEKRRRDEEEARIKQQESQMQQRPEAHKELPVPNQGPGAKPNEDLQMKVQDSTMQWYQQLQEASSRCVLAFEGLSNSKDSQAKKIKMDLQKAATIPVSQISTIAGSKLKEIFDKIHSLLSGKPVQSGGRSVSVTLNPQGLDFVQYKLAEKFVKQGEEEVASHHEAAFPIAVVASGIWELHPRVGALILAHLHKKCPYSVPFYPAFKEGMALEDYQRMLGYQVKDSKVEQQDNFLKRMSGMIRLYAAIIQLRWPYGNRQETHPHGLNHGWRWLAQILNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMILLIKEDYFPRIEAITSSGQMGSFIRLKQFLEKCLQHREVPVPKGFLTASFWRS", "length": 698, "header": "sp|Q3ZBK7-1|GLE1_BOVIN Isoform 1 of mRNA export factor GLE1 OS=Bos taurus OX=9913 GN=GLE1 PE=2 SV=1 CANONICAL=Q3ZBK7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 351, "end_pos": 351, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7" } ], "site_lbl": "Ser351" }, { "start_pos": 41, "end_pos": 41, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7" } ], "site_lbl": "Ser41" }, { "start_pos": 88, "end_pos": 88, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7" } ], "site_lbl": "Ser88" }, { "start_pos": 99, "end_pos": 99, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7" } ], "site_lbl": "Ser99" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540982", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540982", "resource": "KEGG Pathway" }, { "id": "R-BTA-159236", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159236", "resource": "Reactome", "description": "Transport of Mature mRNA derived from an Intron-Containing Transcript" } ], "orthologs": [ { "uniprot_canonical_ac": "Q4KLN4-1", "protein_name": "mRNA export factor GLE1", "gene_name": "Gle1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPSDGRCWETLRALRNSSKGRLRYDREWLLRYEDVLEECMSLPKLSSYSGWVVDHILPNTSHHTQENAPSSDNSPSSGSASGLYQSTLKSPVRSSPQSPSPSTPSGTQSAHESPFTEPIALQSSRAIKVEGCIRMYELAHRMRGTEGLRQWQEEQERKVQALSEMASEQLKRFDELKELKLHKEFRDLQEVMEKSTREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQEQLRKEEGQIRLRSLYTLQEEVLQLNQQLDASSQHKDLLNVDLAAFQTRGNQLCGLISGIIRTTLESGYPTAENQAEAERVLQEMRDLLSNLEQEITRASEMKKKDEEEARVKLQESQVQQGPGAPTKTSAPSPSLVGTQSEDLQVKVQDSTMQWYQQLQDASAKCVLAFEDLTSSKDSQIKKIKMDLQKAATIPVSQISTIAGSKLKEVFDKIHSLLSGKPVQSGGRSVCVTLNPQGLDFVQYKLAEKFVKQGEEEVASHHEAAFPIAVVASGIWMLHPKVGDLILAHLHKKCPYSVPFYPAFKEGMPLEDYQRMLGYQVTDSKVEQQDNFLKRMSGMIRLYAAIIQLQWPYGSRQEAHPHGLNHGWRWLAQILNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMILLIKEDYFPRIEAITSSGQMGSFIRLKQFLEKCLQRREIPVPKGFLTPSFWRS", "length": 698 }, "evidence": [ { "id": "Q3ZBK7", "url": "https://omabrowser.org/oma/group/Q3ZBK7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q53GS7-1", "protein_name": "mRNA export factor GLE1", "gene_name": "GLE1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPSEGRCWETLKALRSSDKGRLCYYRDWLLRREDVLEECMSLPKLSSYSGWVVEHVLPHMQENQPLSETSPSSTSASALDQPSFVPKSPDASSAFSPASPATPNGTKGKDESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAKKIKMDLQKAATIPVSQISTIAGSKLKEIFDKIHSLLSGKPVQSGGRSVSVTLNPQGLDFVQYKLAEKFVKQGEEEVASHHEAAFPIAVVASGIWELHPRVGDLILAHLHKKCPYSVPFYPTFKEGMALEDYQRMLGYQVKDSKVEQQDNFLKRMSGMIRLYAAIIQLRWPYGNRQEIHPHGLNHGWRWLAQILNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMLILIKEDYFPRIEAITSSGQMGSFIRLKQFLEKCLQHKDIPVPKGFLTSSFWRS", "length": 698 }, "evidence": [ { "id": "Q3ZBK7", "url": "https://omabrowser.org/oma/group/Q3ZBK7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q55FW7-1", "protein_name": "mRNA export factor GLE1", "gene_name": "gle1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNKTSSNNISNTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNRILSPFKRNNSKENGNGSVTITLEPLVSPFKLIKSNFKDDVHTNNINNNNNKIKRFLDEDNEFEITIPIRRSGNSINFNIGIVPSSNKKQQQQQQQQQKQKQKKKKTLSPLKKAPGIYSLKDLTIDSDSDSDSYSDNDDNEEYNIKLKSPIKNKIVNNNNNQQQQQKQKEKEEKEEKEKVEKDKKEKDKKKLILNSFQSELIINRVEREREIKINRIVEEKNKEIDDKWVEIKEYNQNQMIKERKEFHSQQIRLNNLIKKQHKKDIKEFSIKLKQAKQKHQSELSESLSLLNQLNKLEQQEIDRHNEELLKYELAIKEEKRKQQQLIERYEQKKREEKQRQLQQEQKEKQEKLEKEEKEKEQQEQQKQLLIKLAKEKEEKEKFEKEQQQQKEKELQKEKELLQQKEKEKEKEKLQQQQQQQQQQQQQQQQQLQQQQQQQNQQNNNLGYIKKDGIIFSLNENSKNFNDFKERSKEFDMIIKFINEKKSMLSREMVEFERQNSKLINIAINQISASQEQVNEKTNKLIKSIQDSQQSDYLKKSTILSIVKKSLSQVESQITFHNASSFPLALVLVRVGEKYPELIDCLLASLNEKCCYTVPYYVSPKENESQSSISKRMGYAFSNDIVGDNDKPIETEDEFHKRICGYLSLYCALILKSEQPHKSSSSSSSSSSSTMMFGFGTQIGNNNNNKLINKNLNIESSLRWLKDLVSLRPRRITSYLFVTFFTHLGNLLSKNQKSSLEFKIIVGKIVEENFFNQMNKPGTEGSFSRLKNLIEEYYKTGTFQQHEGVDF", "length": 837 }, "evidence": [ { "id": "Q3ZBK7", "url": "https://omabrowser.org/oma/group/Q3ZBK7/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6DRB1-1", "protein_name": "mRNA export factor GLE1", "gene_name": "gle1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPSENLRWETLEALKNSPKGKLKYSPDWVEKGEDVLAGCVEVPSLSPLSGQILKRMSPRMLLKNCSRSSSVRDTSPGLSEEAAVCRSAPISPRLKRSSCSLPAVSIQTEEEEEKEEEEKAEVVVEAPAVSPEASVSTPPAVSVLSPRATQISGCIRMCEQKHKAKAKMELSLRQEQQERLVATVANHESEQLKRFEEFMELKQRQEHQSIRDTNEKEAQESLGRQEKLREEHRHRMKILNLRLREMEQQRLREVELERQRQVEGRERHRAINAIQEEVLQLNRLLQPQQSTHAEVEHAPYITRGNQLCSQLSEVVPAAADDQFPSVEDLSVAERALQEMRSLVRSLQEAVSQAAERKKKKEQEEEEEKRRQEQLKAQQEEQKKSAALSAKEKAKKEGLQTGADDSTLKWYNSLQDLANQCAQAFDDLNKAKDTQTKKLKMELQKAATTPVSQIANSSGAPLKEAFEKIDKLLSRRPVTSAGKTVSTSQHPQGLEFASYRLAEKFVKQGEEEVASNHSAAFPIGAVASGIWELHPKIGDLILAHLHKKCPYAVPHYPPMESGTSVEDYQKILGYRVDEGKVEGQDSFLKRMSGMIRLYAAIIQMRWPYSSKQGLHLHGMNHGWRWMAQILNMEPLADITATILFDFLEVCGNALMKQYRVQFWKLILIINEEYFPRYLCFASILHFTCIHWLQNIE", "length": 695 }, "evidence": [ { "id": "Q3ZBK7", "url": "https://omabrowser.org/oma/group/Q3ZBK7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8R322-1", "protein_name": "mRNA export factor GLE1", "gene_name": "Gle1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPSDGRCWETLRALRNTSKGRLRYDREWLLRYEDVLEECMSLPKLSSYSGWVVDHILPNTSGHTQESAPSSDNSPSSGSASGLYQSSLLKSPVRSSPQSPSPSSPNGTQSTHESPFTEPIAPQSSRAIKVEGCIRMYELAHRMRGTEGLRQWQEEQERKVRALSEMASEQLKRFDELKELKLHKEFQDLQEVMEKSTREALGHQEKLKEEHRHRAKILNLKLREAEQQRVKQAEQEQLRKEEGQVRLRSLYSLQEEVLQLNQQLDASSQHKELLSVDLAAFQTRGNQLCGLISSIIRTTLESGYPTAENQAEAERALQEMRDLLSDLEQEITRASQVKKKHEEEAKVKRQESQVQQGPAPPTQTSAPSPSPVGAQNEDLQVKVQDSTMQWYQQLQDASAKCVLAFEDLTSSKDSQTKKIKMDLQKAATIPVSQISTIAGSKLKEIFDKIHSLLSGKPVQSGGRSVSVTLNPQGLDFVQYKLAEKFVKQGEEEVASHHEAAFPIAVVASGIWMLHPKVGDLILAHLHKKCPYSVPFYPAFKEGMALEDYQRMLGYQVTDSKVEQQDNFLKRMSGMIRLYAAIIQLQWPYGNRQEAHPHGLNHGWRWLAQVLNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMILLIKEDYFPRIEAITSSGQMGSFIRLKQFLEKCLQRREIPVPRGFLTTSFWRS", "length": 699 }, "evidence": [ { "id": "Q3ZBK7", "url": "https://omabrowser.org/oma/group/Q3ZBK7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9V4W1-1", "protein_name": "mRNA export factor Gle1", "gene_name": "Gle1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDDMMRAMDCLNMAATLRNAALASATCTGRTLGEDREPIWVEGSRKTPEPPLPEESPAPEPNNEIPLLPKIDFEPNISCFPDLQAINASIVRRELEEEGKRCVRQQLKAIRDKQDAMRLSRETQQRKEERQRDQLQQKALRERNESLLIQKADQMTAAQLEAQQREQLALRQQIDQKLHKLALEGVSRCQRRFNQKYEGIAKILLSLNPETVKVCAAQNTQLKELGQKFEQLVSSVKMGNCEMQSQFLCSIIKAEEFCKSLDALELDIIKQLAEFSEQIQQQLKMEAAKKLEDERQRQQQQEEERQKLEEQQKLEEQEKLRKEKEESAAKEKQQEAETAKADAANVPAPLEPKSQDVPPAATATSTSVHPDRLKFYNDILALYQSKVDAVKPLQTEESLKQYRTGCQRAINLPLNAISAVSPQHLAQNFDKLYSFFAGQPTKVMNGTITINDHPLARDYCMLLMAKKFVSQTETAICSNPQAAFPFASVIITFWKLLPDFGKVFLAYMYKESPFLVPYVIPQQQGQTPEQYLKTIGYRLTDKNELEKPDIYLKRQTGLARLYAAVIISQGRKAAGPDECFELNEGWLWLAHMVHVKPLPDISATLIMEILQTLGFELWRTYGKQFVKLLVYIQNIYMPQLAAYDEGGPKTRLEMLLAKFLRERQIAQAVGVLPPGFW", "length": 677 }, "evidence": [ { "id": "Q3ZBK7", "url": "https://omabrowser.org/oma/group/Q3ZBK7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "poly(A)+ mRNA export from nucleus", "id": "GO:0016973", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016973", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7" } ], "pmid": "" }, { "name": "inositol hexakisphosphate binding", "id": "GO:0000822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000822", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7" } ], "pmid": "" }, { "name": "translation initiation factor binding", "id": "GO:0031369", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031369", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7" } ], "pmid": "" }, { "name": "nuclear pore cytoplasmic filaments", "id": "GO:0044614", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044614", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7" } ], "pmid": "" }, { "name": "nuclear pore", "id": "GO:0005643", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005643", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], 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"uniprot_canonical_ac": "Q8MJN0-1", "uniprot_ac": "Q8MJN0", "uniprot_id": "FUND2_BOVIN", "mass": { "chemical_mass": 20577.0, "monoisotopic_mass": 20577.0 }, "refseq": { "ac": "NP_776763", "name": "FUN14 domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776763" }, "gene_names": [ { "name": "FUNDC2", "type": "recommended", "evidence": [ { "id": "Q8MJN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJN0" } ] }, { "name": "MTCP1", "type": "recommended", "evidence": [ { "id": "Q8MJN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJN0" } ] }, { "name": "FUNDC2", "type": "synonym", "evidence": [ { "id": "NP_776763", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776763" }, { "id": "Q8MJN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJN0" } ] }, { "name": "HCBP6", "type": "synonym", "evidence": [ { "id": "NP_776763", "database": "RefSeq", "url": 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CANONICAL=Q8MJN0-1" }, "locus": { "chromosome": "X", "start_pos": 36013706, "end_pos": 35993853, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022579.4", "url": "https://www.ensembl.org/id/ENSBTAT00000022579.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022579.3", "url": "https://www.ensembl.org/id/ENSBTAP00000022579.3" } ] } }, { "isoform_ac": "G3N2C7-1", "url": "https://www.uniprot.org/uniprotkb/Q8MJN0/entry#G3N2C7-1", "sequence": { "sequence": "MAGQDVGAPPDRLWVHQEGVYRDEYQRTWVAVLEEETSFLRARVQQVQVPLGDAARPSHLLTSQLPLMWQLYPEERYMDNNSRLWQIQHHLMVRGVEELLLKLLPDD", "length": 107, "header": "tr|G3N2C7-1|FUND2_BOVIN Computationally mapped isoform of FUN14 domain-containing protein 2 OS=Bos taurus OX=9913 GN=FUNDC2 PE=2 SV=1 CANONICAL=Q8MJN0-1" }, "locus": { "chromosome": "X", "start_pos": 35971603, "end_pos": 35971087, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063244.4", "url": 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"G3MXQ2", "url": "https://www.uniprot.org/uniprotkb/G3MXQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MXQ2-1", "url": "https://www.uniprot.org/uniprotkb/G3MXQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8MKI3", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8MKI3-1", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDEEVEHVEEEYEEEEEAQEEAPPPPAEVPEVHEEVHEVHEPEEVQEEEKPRPRLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKVLAERRKPLNIDHLSEDKLRDKAKELWDTLYQLETDKFEYGEKLKRQKYDITNLRSRIDQAQKHSKKAGTAPKGKVGGRWK", "length": 271, "header": "sp|Q8MKI3-1|TNNT3_BOVIN Isoform 1 of Troponin T, fast skeletal muscle OS=Bos taurus OX=9913 GN=Tnnt3 PE=2 SV=1 CANONICAL=Q8MKI3-1" }, "isoforms": [ { "isoform_ac": "A0A3S5ZPQ2-1", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3/entry#A0A3S5ZPQ2-1", "sequence": { "sequence": "MSDEEVEHVEEEAQEEEEVQEEEKPRPRLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKVLAERRKPLNIDHLSEDKLRDKAKELWDTLYQLETDKFEYGEKLKRQKYDITNLRSRIDQAQKHSKKAGTAPKGKVGGRWK", "length": 244, "header": "tr|A0A3S5ZPQ2-1|TNNT3_BOVIN Computationally mapped isoform of Troponin T, fast skeletal muscle OS=Bos taurus OX=9913 GN=Tnnt3 PE=2 SV=2 CANONICAL=Q8MKI3-1" }, "locus": { "chromosome": "29", "start_pos": 49591561, "end_pos": 49579205, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008371.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008371.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008371.7", "url": "https://www.ensembl.org/id/ENSBTAP00000008371.7" } ] } }, { "isoform_ac": "A0A3S5ZPW2-1", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3/entry#A0A3S5ZPW2-1", "sequence": { "sequence": "MSDEEVEHVEEEYEEEEEAQEEAAEVPEVHEEVHEPEEKPRPRLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKVLAERRKPLNIDHLSEDKLRDKAKELWDTLYQLETDKFEYGEKLKRQKYDIMNVRARVEMLAKFSKKAGTAPKGKVGGRWK", "length": 259, "header": "tr|A0A3S5ZPW2-1|TNNT3_BOVIN Computationally mapped isoform of Troponin T, fast skeletal muscle OS=Bos taurus OX=9913 GN=Tnnt3 PE=2 SV=1 CANONICAL=Q8MKI3-1" }, "locus": { "chromosome": "29", "start_pos": 49591561, "end_pos": 49579205, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029890.6", "url": "https://www.ensembl.org/id/ENSBTAT00000029890.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029885.6", "url": "https://www.ensembl.org/id/ENSBTAP00000029885.6" } ] } }, { "isoform_ac": "A0A3S5ZPW3-1", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3/entry#A0A3S5ZPW3-1", "sequence": { "sequence": "MSDEEVVSASFKTPGPPHPAPPPPAEVPEVHEEVNHHGGDLLTVLMSPSLFFRLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKVLAERRKPLNIDHLSEDKLRDKAKELWDTLYQLETDKFEYGEKLKRQKYDITNLRSRIDQAQKHSKKAGTAPKGKVGGRWK", "length": 269, "header": "tr|A0A3S5ZPW3-1|TNNT3_BOVIN Computationally mapped isoform of Troponin T, fast skeletal muscle OS=Bos taurus OX=9913 GN=Tnnt3 PE=2 SV=2 CANONICAL=Q8MKI3-1" }, "locus": { "chromosome": "29", "start_pos": 49591561, "end_pos": 49579205, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008422.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008422.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008422.7", "url": "https://www.ensembl.org/id/ENSBTAP00000008422.7" } ] } }, { "isoform_ac": "A0A452DJI6-1", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3/entry#A0A452DJI6-1", "sequence": { "sequence": "MSDEEVIRQLQDPRASCAQRPEETPPPCKELTPHHSPSQRARGGLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKVLAERRKPLNIDHLSEDKLRDKAKELWDTLYQLETDKFEYGEKLKRQKYDITNLRSRIDQAQKHSKKAGTAPKGKVGGRWK", "length": 260, "header": "tr|A0A452DJI6-1|TNNT3_BOVIN Computationally mapped isoform of Troponin T, fast skeletal muscle OS=Bos taurus OX=9913 GN=Tnnt3 PE=2 SV=2 CANONICAL=Q8MKI3-1" }, "locus": { "chromosome": "29", "start_pos": 49591561, "end_pos": 49579205, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064506.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064506.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054396.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054396.3" } ] } }, { "isoform_ac": "A0AAA9TM98-1", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3/entry#A0AAA9TM98-1", "sequence": { "sequence": "MSDEEVEHVEEEYEEEEEAQEEEEVQEDAEQEDWEDQAEEKPRPRLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKVLAERRKPLNIDHLSEDKLRDKAKELWDTLYQLETDKFEYGEKLKRQKYDITNLRSRIDQAQKHSKKAGTAPKGKVGGRWK", "length": 261, "header": "tr|A0AAA9TM98-1|TNNT3_BOVIN Computationally mapped isoform of Troponin T, fast skeletal muscle OS=Bos taurus OX=9913 GN=Tnnt3 PE=2 SV=1 CANONICAL=Q8MKI3-1" }, "locus": { "chromosome": "29", "start_pos": 49591561, "end_pos": 49579205, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102080.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102080.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098369.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098369.1" } ] } }, { "isoform_ac": "A0ABZ3NN16-1", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3/entry#A0ABZ3NN16-1", "sequence": { "sequence": "MSASLSGAWSAHCPRSPSLGLLPSRPPRAWPLTTVSFPLSLLLPLVPTAEEAQEEAPPPPAEVPEVHEEVHEVHEPEEVQEEEKPRPRLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKVLAERRKPLNIDHLSEDKLRDKAKELWDTLYQLETDKFEYGEKLKRQKYDITNLRSRIDQAQKHSKKAGTAPKGKVGGRWK", "length": 304, "header": "tr|A0ABZ3NN16-1|A0ABZ3NN16_BOVIN Computationally mapped isoform of Troponin T, fast skeletal muscle OS=Bos taurus OX=9913 GN=TNNT3 PE=3 SV=1 CANONICAL=Q8MKI3-1" }, "locus": { "chromosome": "29", "start_pos": 49590048, "end_pos": 49579205, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080664.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080664.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070168.3", "url": "https://www.ensembl.org/id/ENSBTAP00000070168.3" } ] } }, { "isoform_ac": "G3MXQ2-1", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3/entry#G3MXQ2-1", "sequence": { "sequence": "MSDEEVEHVEEEYEEEEEAQEEEEKPRPRLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKVLAERRKPLNIDHLSEDKLRDKAKELWDTLYQLETDKFEYGEKLKRQKYDITNLRSRIDQAQKHSKKAGTAPKGKVGGRWK", "length": 245, "header": "tr|G3MXQ2-1|TNNT3_BOVIN Computationally mapped isoform of Troponin T, fast skeletal muscle OS=Bos taurus OX=9913 GN=Tnnt3 PE=2 SV=2 CANONICAL=Q8MKI3-1" }, "locus": { "chromosome": "29", "start_pos": 49591561, "end_pos": 49579205, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064427.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064427.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054320.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054320.3" } ] } }, { "isoform_ac": "Q8MKI3-1", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3/entry#Q8MKI3-1", "sequence": { "sequence": "MSDEEVEHVEEEYEEEEEAQEEAPPPPAEVPEVHEEVHEVHEPEEVQEEEKPRPRLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKVLAERRKPLNIDHLSEDKLRDKAKELWDTLYQLETDKFEYGEKLKRQKYDITNLRSRIDQAQKHSKKAGTAPKGKVGGRWK", "length": 271, "header": "sp|Q8MKI3-1|TNNT3_BOVIN Isoform 1 of Troponin T, fast skeletal muscle OS=Bos taurus OX=9913 GN=Tnnt3 PE=2 SV=1 CANONICAL=Q8MKI3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 161, "end_pos": 161, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8MKI3", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3" } ], "site_lbl": "Ser161" }, { "start_pos": 168, "end_pos": 168, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8MKI3", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3" } ], "site_lbl": "Ser168" }, { "start_pos": 169, "end_pos": 169, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8MKI3", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3" } ], "site_lbl": "Ser169" }, { "start_pos": 205, "end_pos": 205, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8MKI3", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3" } ], "site_lbl": "Ser205" }, { "start_pos": 221, "end_pos": 221, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q8MKI3", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3" } ], "site_lbl": "Tyr221" }, { "start_pos": 2, "end_pos": 2, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8MKI3", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3" } ], "site_lbl": "Ser2" }, { "start_pos": 90, "end_pos": 90, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8MKI3", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3" } ], "site_lbl": "Ser90" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Amino acid sequences of multiple fast and slow troponin T isoforms expressed in adult bovine skeletal muscles.", "journal": "J. Anim. Sci.", "date": "2003", "authors": "Muroya S, Nakajima I, Chikuni K", "evidence": [ { "database": "UniProtKB", "id": "Q8MKI3", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3" } ], "reference": [ { "type": "PubMed", "id": "12772845", "url": "https://glygen.org/publication/PubMed/12772845" } ] } ], "pathway": [ { "id": "bta:282096", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282096", "resource": "KEGG Pathway" }, { "id": "R-BTA-390522", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390522", "resource": "Reactome", "description": "Striated Muscle Contraction" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "troponin C binding", "id": "GO:0030172", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030172", "evidence": [ { "database": "UniProtKB", "id": "Q8MKI3", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3" } ], "pmid": "" }, { "name": "tropomyosin binding", "id": "GO:0005523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005523", "evidence": [ { "database": "UniProtKB", "id": "Q8MKI3", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3" } ], "pmid": "" }, { "name": "troponin I binding", "id": "GO:0031013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031013", "evidence": [ { "database": "UniProtKB", "id": "Q8MKI3", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "skeletal muscle contraction", "id": "GO:0003009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003009", "evidence": [ { "database": "UniProtKB", "id": "Q8MKI3", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3" } ], "pmid": "" }, { "name": "sarcomere organization", "id": "GO:0045214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045214", "evidence": [ { "database": "UniProtKB", "id": "Q8MKI3", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3" } ], "pmid": "" }, { "name": "regulation of muscle contraction", "id": "GO:0006937", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006937", "evidence": [ { "database": "UniProtKB", "id": "Q8MKI3", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "troponin complex", "id": "GO:0005861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005861", "evidence": [ { "database": "UniProtKB", "id": "Q8MKI3", "url": "https://www.uniprot.org/uniprotkb/Q8MKI3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q8MKI3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 271, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q8MKI3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q8MKI3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 2, 90, 161, 168, 169, 205, 221 ], "sequon_annotation_sites": [ { "start_pos": 166, "end_pos": 168 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZCC4-1", "uniprot_ac": "Q3ZCC4", "uniprot_id": "TIPIN_BOVIN", "mass": { "chemical_mass": 32743.0, "monoisotopic_mass": 32743.0 }, "refseq": { "ac": "NP_001276920", "name": "TIMELESS-interacting protein isoform 2", "summary": "The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM and aids in protecting cells against DNA damage and stress. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276920" }, "gene_names": [ { "name": "TIPIN", "type": "recommended", "evidence": [ { "id": "Q3ZCC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4" } ] }, { "name": "TIPIN", "type": "synonym", "evidence": [ { "id": "NP_001276920", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276920" } ] } ], "protein_names": [ { "name": "TIMELESS-interacting protein", "type": "recommended", "evidence": [ { "id": "Q3ZCC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4/entry#names_and_taxonomy" } ] }, { "name": "TIMELESS-interacting protein isoform 2", "type": "synonym", "evidence": [ { "id": "NP_001276920", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276920" } ] } ], "function": [ { "annotation": "Plays an important role in the control of DNA replication and the maintenance of replication fork stability.", "evidence": [ { "database": "UniProtKB", "id": "A0A452DHP4", "url": "https://www.uniprot.org/uniprotkb/A0A452DHP4#function" }, { "database": "UniProtKB", "id": "RU366049", "url": "https://www.uniprot.org/uniprotkb/RU366049#function" }, { "database": "UniProtKB", "id": "A0A3Q1MMM2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMM2#function" }, { "database": "UniProtKB", "id": "A0AAF7A521", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A521#function" }, { "database": "UniProtKB", "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4#function" }, { "database": "UniProtKB", "id": "Q9BVW5", "url": "https://www.uniprot.org/uniprotkb/Q9BVW5#function" } ] }, { "annotation": "The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM and aids in protecting cells against DNA damage and stress. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014].", "evidence": [ { "database": "RefSeq", "id": "NP_001276920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276920" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TIPIN", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4", "locus": { "chromosome": "10", "start_pos": 13235273, "end_pos": 13252303, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000372", "url": "https://www.ensembl.org/id/ENSBTAG00000000372" } ] } } ], "crossref": [ { "id": "Q3ZCC4", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCC4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000372", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000372", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506176", "url": "https://www.ncbi.nlm.nih.gov/gene/506176", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012923", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012923", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506176", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506176", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IIHEDFI", "url": "https://omabrowser.org/oma/group/IIHEDFI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MMM2", "url": "https://www.orthodb.org/?gene=A0A3Q1MMM2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DHP4", "url": "https://www.orthodb.org/?gene=A0A452DHP4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZCC4", "url": "https://www.orthodb.org/?gene=Q3ZCC4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13220", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13220", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13220:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13220:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07962", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07962", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001276920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276920", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMM2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMM2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMM2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DHP4", "url": "https://www.uniprot.org/uniprotkb/A0A452DHP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DHP4-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DHP4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A521", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A521", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A521-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A521-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCC4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLEPQENGLTDLPDYEHIEDETFPPFPPPASPGREDGEGAEPEEESGRGAPVPVPPKRTVKRNIPKLNAERLISERGLPALRHVFEKAKFKGKGHEAEDLKTLIRHMEHWAHRLFPKLQFEDFIDRVECLGNKKEVQTCLKRIRLDLPILHEDFVSNNDEVEENNGHDVTATELDHFLTNSYGSVEFASESSRSLTEEEQQRIERNKQLALERRQAKLLSNSQSLGNDLSVNTPSTQTSEAGSTGEEQKEEESNGFNKDLLDSPHNAGAASTVNEEEQLKVEETQLDQSF", "length": 290, "header": "sp|Q3ZCC4-1|TIPIN_BOVIN Isoform 1 of TIMELESS-interacting protein OS=Bos taurus OX=9913 GN=TIPIN PE=2 SV=1 CANONICAL=Q3ZCC4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MMM2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4/entry#A0A3Q1MMM2-1", "sequence": { "sequence": "MLEPQENGLTDLPDYEHIEDETFPPFPPPASPGREDGEGAEPEEESGRGAPVPVPPKRTVKRNIPKLNAERLISERGLPALRHVFEKAKFKGKGHETCLKRIRLDLPILHEDFVSNNDEVEENNGHDVTATELDHFLTNSYGSVEFASESSRSLTEEEQQRIERNKQLALERRQAKLLSNSQSLGNDLSVNTPSTQTSEAGSTGEEQKEEESNGFNKDLLDSPHNAGAASTVNEEEQLKVEETQLDQSF", "length": 249, "header": "tr|A0A3Q1MMM2-1|TIPIN_BOVIN Computationally mapped isoform of TIMELESS-interacting protein OS=Bos taurus OX=9913 GN=TIPIN PE=2 SV=1 CANONICAL=Q3ZCC4-1" }, "locus": { "chromosome": "10", "start_pos": 13242925, "end_pos": 13235916, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086279.1", "url": "https://www.ensembl.org/id/ENSBTAT00000086279.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072414.1", "url": "https://www.ensembl.org/id/ENSBTAP00000072414.1" } ] } }, { "isoform_ac": "A0A452DHP4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4/entry#A0A452DHP4-1", "sequence": { "sequence": "MIFKTSGWSGEEKMLEPQENGLTDLPDYEHIEDETFPPFPPPASPGREDGEGAEPEEESGRGAPVPVPPKRTVKRNIPKLNAERLISERGLPALRHVFEKAKFKGKGHEAEDLKTLIRHMEHWAHRLFPKLQFEDFIDRVECLGNKKEVQTCLKRIRLDLPILHEDFVSNNDEVEENNGHDVTATELDHFLTNSYGSVEFASESSRSLTEEEQQRIERNKQLALERRQAKLLSNSQSLGNDLSVNTPSTQTSEAGSTGEEQKEEESNGFNKDLLDSPHNAGAASTVNEEEQLKVEETQLDQSF", "length": 303, "header": "tr|A0A452DHP4-1|TIPIN_BOVIN Computationally mapped isoform of TIMELESS-interacting protein OS=Bos taurus OX=9913 GN=TIPIN PE=2 SV=1 CANONICAL=Q3ZCC4-1" }, "locus": { "chromosome": "10", "start_pos": 13243314, "end_pos": 13235916, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000482.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000482.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000482.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000482.6" } ] } }, { "isoform_ac": "A0AAF7A521-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4/entry#A0AAF7A521-1", "sequence": { "sequence": "MGGRDLGEVGLVGTAQGVRRFGAERQGIFSREFERNVVFLPRGTLRCWRQRPEREEKMLEPQENGLTDLPDYEHIEDETFPPFPPPASPGREDGEGAEPEEESGRGAPVPVPPKRTVKRNIPKLNAERLISERGLPALRHVFEKAKFKGKGHEAEDLKTLIRHMEHWAHRLFPKLQFEDFIDRVECLGNKKEVQTCLKRIRLDLPILHEDFVSNNDEVEENNGHDVTATELDHFLTNSYGSVEFASESSRSLTEEEQQRIERNKQLALERRQAKLLSNSQSLGNDLSVNTPSTQTSEAGSTGEEQKEEESNGFNKDLLDSPHNAGAASTVNEEEQLKVEETQLDQSF", "length": 347, "header": "tr|A0AAF7A521-1|TIPIN_BOVIN Computationally mapped isoform of TIMELESS-interacting protein OS=Bos taurus OX=9913 GN=TIPIN PE=2 SV=1 CANONICAL=Q3ZCC4-1" }, "locus": { "chromosome": "10", "start_pos": 13252263, "end_pos": 13235916, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068089.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068089.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062695.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062695.2" } ] } }, { "isoform_ac": "Q3ZCC4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4/entry#Q3ZCC4-1", "sequence": { "sequence": "MLEPQENGLTDLPDYEHIEDETFPPFPPPASPGREDGEGAEPEEESGRGAPVPVPPKRTVKRNIPKLNAERLISERGLPALRHVFEKAKFKGKGHEAEDLKTLIRHMEHWAHRLFPKLQFEDFIDRVECLGNKKEVQTCLKRIRLDLPILHEDFVSNNDEVEENNGHDVTATELDHFLTNSYGSVEFASESSRSLTEEEQQRIERNKQLALERRQAKLLSNSQSLGNDLSVNTPSTQTSEAGSTGEEQKEEESNGFNKDLLDSPHNAGAASTVNEEEQLKVEETQLDQSF", "length": 290, "header": "sp|Q3ZCC4-1|TIPIN_BOVIN Isoform 1 of TIMELESS-interacting protein OS=Bos taurus OX=9913 GN=TIPIN PE=2 SV=1 CANONICAL=Q3ZCC4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 194, "end_pos": 194, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4" } ], "site_lbl": "Ser194" }, { "start_pos": 222, "end_pos": 222, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4" } ], "site_lbl": "Ser222" }, { "start_pos": 233, "end_pos": 233, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4" } ], "site_lbl": "Thr233" }, { "start_pos": 244, "end_pos": 244, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4" } ], "site_lbl": "Thr244" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506176", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506176", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z3X0-1", "protein_name": "TIMELESS-interacting protein", "gene_name": "TIPIN", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAMIDPLENNLFDLPDYENTEDETFPPLPPPTSPGRGDAEWAQANGDPDGNQQSETKDSSSAARKAVKRSIPKLDANRLVSERGLPALRHMFDNVNFKGKGHEAEDLKTLLRHMEHWAHRLFPKLQFDDFIDRVESLGNKKEVQTCLKRIRLDLPILHEDFTANEGGGGESNGLDMATEEVHSFSGNVGELDSLPGTTLTEEQQQRIKRNRQLALERRQAKMQCNSQSQHDELSPSYPEEELNIPVARDLTGALEDTQVTATNVAVTETEDRERELQCASEKQ", "length": 283 }, "evidence": [ { "id": "Q3ZCC4", "url": "https://omabrowser.org/oma/group/Q3ZCC4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6DBR4-1", "protein_name": "TIMELESS-interacting protein", "gene_name": "tipin", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MIDPLENGLFDIPDYEQIEDETFPPLPPPLSPGRAELEDDLFGNAEGEEEGEVSKLAEVPVAKRRTVKRPRPKLDANRLISEKGLPALRTLFEDVKFKGKGHETENLKLLMLKMENWAHRLYPKMQFEEFIDKVENLGGKKEVQTCLKRIRLDMPITHEDYVAEEAEIQVPEESVPSGDGGFPEDPFIHSTPAPASLTEEQQQRIELNKRLALERRLAKQKQLESTPISIQEDADEPSTSSSGQFLSEENPKTTSNQTPLKHKPAELQESPLHDNESSSHIANGIIDDDDDDDD", "length": 294 }, "evidence": [ { "id": "Q3ZCC4", "url": "https://omabrowser.org/oma/group/Q3ZCC4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q91WA1-1", "protein_name": "TIMELESS-interacting protein", "gene_name": "Tipin", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLEQEENGLFEIPDYEHVEDETFPPFPPPASPERDPADAEPEEGSGSGVPVPPKRTVKRNLPKLDATRLTSERGLPALRHVFDKTKFKGKGHEAEDLKTLIRHMEHWAHRLFPKLQFEDFIDRVENLGNKKEVQTCLKRIRLDLPIVHEDFVNNNDEVGEANGPDVSATGFDPFLTSSSDSRKFASEPTRSLTEEQQQRIERNKQLALERRQAKLLSNSQSLENDVTVEENSTGEDQEESNGLNIDTADGPHDVPFASTHEEEQCKAEETQLDHTNLD", "length": 278 }, "evidence": [ { "id": "Q3ZCC4", "url": "https://omabrowser.org/oma/group/Q3ZCC4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BVW5-1", "protein_name": "TIMELESS-interacting protein", "gene_name": "TIPIN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLEPQENGVIDLPDYEHVEDETFPPFPPPASPERQDGEGTEPDEESGNGAPVRVPPKRTVKRNIPKLDAQRLISERGLPALRHVFDKAKFKGKGHEAEDLKMLIRHMEHWAHRLFPKLQFEDFIDRVEYLGSKKEVQTCLKRIRLDLPILHEDFVSNNDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRAHTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR", "length": 301 }, "evidence": [ { "id": "Q3ZCC4", "url": "https://omabrowser.org/oma/group/Q3ZCC4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "DNA replication checkpoint signaling", "id": "GO:0000076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000076", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4" } ], "pmid": "" }, { "name": "mitotic intra-S DNA damage checkpoint signaling", "id": "GO:0031573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031573", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4" } ], "pmid": "" }, { "name": "cell cycle phase transition", "id": "GO:0044770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044770", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4" } ], "pmid": "" }, { "name": "replication fork arrest", "id": "GO:0043111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043111", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4" } ], "pmid": "" }, { "name": "replication fork processing", "id": "GO:0031297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031297", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "replication fork protection complex", "id": "GO:0031298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031298", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCC4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 290, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCC4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCC4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 194, 222, 233, 244 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBP3-1", "uniprot_ac": "Q3ZBP3", "uniprot_id": "RBMS1_BOVIN", "mass": { "chemical_mass": 44112.0, "monoisotopic_mass": 44112.0 }, "refseq": { "ac": "NP_001030438", "name": "RNA-binding motif, single-stranded-interacting protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030438" }, "gene_names": [ { "name": "RBMS1", "type": "recommended", "evidence": [ { "id": "Q3ZBP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3" } ] }, { "name": "RBMS1", "type": "synonym", "evidence": [ { "id": "NP_001030438", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030438" } ] } ], "protein_names": [ { "name": "RNA-binding motif, single-stranded-interacting protein 1", "type": "recommended", "evidence": [ { "id": "Q3ZBP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding motif, single-stranded-interacting protein 1", "type": "synonym", "evidence": [ { "id": "NP_001030438", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030438" } ] } ], "function": [ { "annotation": "Single-stranded DNA binding protein that interacts with the region upstream of the C-myc gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RBMS1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3", "locus": { "chromosome": "2", "start_pos": 36074515, "end_pos": 35855198, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005180", "url": "https://www.ensembl.org/id/ENSBTAG00000005180" } ] } } ], "crossref": [ { "id": "Q3ZBP3", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBP3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005180", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005180", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12470", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12470", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12473", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12473", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "526135", "url": "https://www.ncbi.nlm.nih.gov/gene/526135", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002343", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002343", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526135", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526135", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TMEHTMS", "url": "https://omabrowser.org/oma/group/TMEHTMS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MH35", "url": "https://www.orthodb.org/?gene=A0A3Q1MH35", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MQ64", "url": "https://www.orthodb.org/?gene=A0A3Q1MQ64", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DI22", "url": "https://www.orthodb.org/?gene=A0A452DI22", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBP3", "url": "https://www.orthodb.org/?gene=Q3ZBP3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24012", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24012", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030438", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MH35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MH35-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH35-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQ64", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQ64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQ64-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQ64-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DI22", "url": "https://www.uniprot.org/uniprotkb/A0A452DI22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DI22-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DI22-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYP5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYP5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYP5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC52", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC52-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBP3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBP3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKVWKQQMYPQYATYYYPQYLQAKQSLVPAHPMAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPNTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRILRDSSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPNKYIPNGRPWHREGEAGMTLTYDPTTAAIQNGFYPSPYSIATNRMITQTSITPYIASPVSAYQVQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGSTGTYMPATSAMQGAYLPQYTHVQTAAVPVEEASGQQQVTVETSNDHSPYTFQPNK", "length": 403, "header": "sp|Q3ZBP3-1|RBMS1_BOVIN Isoform 1 of RNA-binding motif, single-stranded-interacting protein 1 OS=Bos taurus OX=9913 GN=RBMS1 PE=2 SV=1 CANONICAL=Q3ZBP3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MH35-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3/entry#A0A3Q1MH35-1", "sequence": { "sequence": "MIFPSSSGNPGGSSSCRTPYRKQQSLVPAHPMAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPNTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRILRDSSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPNKYIPNGRPWHREGEVRLAGMTLTYDPTTAAIQNGFYPSPYSIATNRMITQTSITPYIASPVSAYQVAKETRENKYRGSAVKVQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGSTGTYMPATSAMQGAYLPQYTHVQTAAVPVEEASGQQQVTVETSNDHSPYTFQPNK", "length": 420, "header": "tr|A0A3Q1MH35-1|RBMS1_BOVIN Computationally mapped isoform of RNA-binding motif, single-stranded-interacting protein 1 OS=Bos taurus OX=9913 GN=RBMS1 PE=2 SV=1 CANONICAL=Q3ZBP3-1" }, "locus": { "chromosome": "2", "start_pos": 36073429, "end_pos": 35943158, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078649.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078649.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073547.1", "url": "https://www.ensembl.org/id/ENSBTAP00000073547.1" } ] } }, { "isoform_ac": "A0A3Q1MQ64-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3/entry#A0A3Q1MQ64-1", "sequence": { "sequence": "MGKVWKQQMYPQYATYYYPQYLQAKQSLVPAHPMAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPNTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRILRDSSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPNKYIPNGRPWHREGEVRLAGMTLTYDPTTAAIQNGFYPSPYSIATNRMITQTSITPYIASPVSAYQVQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGSTGTYMPATSAMQGAYLPQYTHVQTAAVPVEEASGQQQVTVETSNDHSPYTFQPNK", "length": 406, "header": "tr|A0A3Q1MQ64-1|RBMS1_BOVIN Computationally mapped isoform of RNA-binding motif, single-stranded-interacting protein 1 OS=Bos taurus OX=9913 GN=RBMS1 PE=2 SV=2 CANONICAL=Q3ZBP3-1" }, "locus": { "chromosome": "2", "start_pos": 36073429, "end_pos": 35855477, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086691.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086691.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073714.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073714.2" } ] } }, { "isoform_ac": "A0A452DI22-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3/entry#A0A452DI22-1", "sequence": { "sequence": "MDSLVPAHPMAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPNTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRILRDSSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPNKYIPNGRPWHREGEVRLAGMTLTYDPTTAAIQNGFYPSPYSIATNRMITQTSITPYIASPVSAYQVQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGSTGTYMPATSAMQGAYLPQYTHVQTAAVPVEEASGQQQVTVETSNDHSPYTFQPNK", "length": 382, "header": "tr|A0A452DI22-1|RBMS1_BOVIN Computationally mapped isoform of RNA-binding motif, single-stranded-interacting protein 1 OS=Bos taurus OX=9913 GN=RBMS1 PE=2 SV=2 CANONICAL=Q3ZBP3-1" }, "locus": { "chromosome": "2", "start_pos": 36073429, "end_pos": 35952685, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006826.8", "url": "https://www.ensembl.org/id/ENSBTAT00000006826.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006826.7", "url": "https://www.ensembl.org/id/ENSBTAP00000006826.7" } ] } }, { "isoform_ac": "A0AAA9RYP5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3/entry#A0AAA9RYP5-1", "sequence": { "sequence": "MGKVWKQQMYPQYATYYYPQYLQAKQSLVPAHPMAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPNTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRILRDSSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPNKYIPNGRPWHREGEVRLAGMTLTYDPTTAAIQNGFYPSPYSIATNRMITQTSITPYIASPVSAYQVAKETRENKYRGSAVKVQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGSTGTYMPATSAMQGAYLPQYTHVQTAAVPVEEASGQQQVTVETSNDHSPYTFQPNK", "length": 422, "header": "tr|A0AAA9RYP5-1|RBMS1_BOVIN Computationally mapped isoform of RNA-binding motif, single-stranded-interacting protein 1 OS=Bos taurus OX=9913 GN=RBMS1 PE=2 SV=1 CANONICAL=Q3ZBP3-1" }, "locus": { "chromosome": "2", "start_pos": 36073429, "end_pos": 35855477, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120653.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120653.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078692.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078692.1" } ] } }, { "isoform_ac": "A0AAA9SC52-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3/entry#A0AAA9SC52-1", "sequence": { "sequence": "MGKVWKQQMYPQYATYYYPQYLQAKQSLVPAHPMAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPNTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRILRDSSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPNKYIPNGRPWHREGEVRLAGMTLTYDPTTAAIQNGFYPSPYSIATNRMITQTSITPYIASPVSAYQGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGSTGTVVHACHVSYARGLLATVHTRADGGSSCGGGEWSAAGDCGDF", "length": 378, "header": "tr|A0AAA9SC52-1|RBMS1_BOVIN Computationally mapped isoform of RNA-binding motif, single-stranded-interacting protein 1 OS=Bos taurus OX=9913 GN=RBMS1 PE=2 SV=1 CANONICAL=Q3ZBP3-1" }, "locus": { "chromosome": "2", "start_pos": 36073392, "end_pos": 35855477, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094620.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094620.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081097.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081097.1" } ] } }, { "isoform_ac": "Q3ZBP3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3/entry#Q3ZBP3-1", "sequence": { "sequence": "MGKVWKQQMYPQYATYYYPQYLQAKQSLVPAHPMAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPNTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRILRDSSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPNKYIPNGRPWHREGEAGMTLTYDPTTAAIQNGFYPSPYSIATNRMITQTSITPYIASPVSAYQVQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGSTGTYMPATSAMQGAYLPQYTHVQTAAVPVEEASGQQQVTVETSNDHSPYTFQPNK", "length": 403, "header": "sp|Q3ZBP3-1|RBMS1_BOVIN Isoform 1 of RNA-binding motif, single-stranded-interacting protein 1 OS=Bos taurus OX=9913 GN=RBMS1 PE=2 SV=1 CANONICAL=Q3ZBP3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 208, "end_pos": 208, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3" } ], "site_lbl": "Thr208" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:526135", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526135", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7G6P3-1", "protein_name": "RNA-binding motif, single-stranded-interacting protein 1 isoform X1", "gene_name": "Rbms1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGKVWKQQMYPQYATYYYPQYLQAKQSLVPAHPMAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPNTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRVLRDSSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPNKYIPNGRPWHREGEVRLAGMTLTYDPTTAALHNGFYPSPYSIATNRMISQTSLTPYIASPVSTYQVAKETRENKYRGSAIKVQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGSTGTYMPATSAMQGAYLPQYTHMQTAAVPVEEASGQQQVAVETSNDHSPYTFQPNK", "length": 422 }, "evidence": [ { "id": "Q3ZBP3", "url": "https://omabrowser.org/oma/group/Q3ZBP3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1RPR6-1", "protein_name": "RNA binding motif single stranded interacting protein 1", "gene_name": "RBMS1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MIFPSSSGNPGGSSSCRTPYRKQQSLVPAPPMAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPNTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRILRDSSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPNKYIPNGRPWHREGEAGMTLTYDPTTAAIQNGFYPSPYSIATNRMITQTSITPYIASPVSAYQVQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGSTGTYMPATSAMQGAYLPQYTHVQTAAVPVEEASGQQQVAVETSNDHSPYTFQPNK", "length": 401 }, "evidence": [ { "id": "Q3ZBP3", "url": "https://omabrowser.org/oma/group/Q3ZBP3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P29558-1", "protein_name": "RNA-binding motif, single-stranded-interacting protein 1", "gene_name": "RBMS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGKVWKQQMYPQYATYYYPQYLQAKQSLVPAHPMAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPHTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRILRDSSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPNKYIPNGRPWHREGEVRLAGMTLTYDPTTAAIQNGFYPSPYSIATNRMITQTSITPYIASPVSAYQVQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGSTGTYMPATSAMQGAYLPQYAHMQTTAVPVEEASGQQQVAVETSNDHSPYTFQPNK", "length": 406 }, "evidence": [ { "id": "Q3ZBP3", "url": "https://omabrowser.org/oma/group/Q3ZBP3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5PQP1-1", "protein_name": "RNA-binding motif, single-stranded-interacting protein 1", "gene_name": "Rbms1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGKVWKQQMYPQYATYYYPQYLQAKQSLVPAHPMAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPNTTDQDLVKLCQPYGKIVSTKAILDKATNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRVLRDSSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPNKYIPNGRPWPREGEAGMTLTYDPTTAALHNGFYPSPYSIATNRMITQTSLTPYIASPVSAYQVQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGSTGTYMPATSAMQGAYLPQYTHMQTATVPVEEASGQQQVTVETSNDHSPYTFPPNK", "length": 403 }, "evidence": [ { "id": "Q3ZBP3", "url": "https://omabrowser.org/oma/group/Q3ZBP3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91W59-1", "protein_name": "RNA-binding motif, single-stranded-interacting protein 1", "gene_name": "Rbms1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGKVWKQQMYPQYATYYYPQYLQAKQSLVPAHPMAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPNTTDQDLVKLCQPYGKIVSTKAILDKATNKCKGYGFVDFDSPAAAQKAVSALKANGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRVLRDSSGASRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPNKYIPNGRPWPRDGEAGMTLTYDPTTAALHNGFYPSPYSIATNRMITQTSLTPYIASPVSAYQVQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGSTGTYMPATSAMQGAYLPQYTHMQTAAVPVEEASGQQQVAVETSNDHSPYTFPPNK", "length": 403 }, "evidence": [ { "id": "Q3ZBP3", "url": "https://omabrowser.org/oma/group/Q3ZBP3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3" } ], "pmid": "" }, { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3" } ], "pmid": "" }, { "name": "poly(A) binding", "id": "GO:0008143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008143", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3" } ], "pmid": "" }, { "name": "poly(U) RNA binding", "id": "GO:0008266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008266", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" }, { "start_pos": 47, "end_pos": 49, "annotation": "n_glycosylation_sequon" }, { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBP3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 403, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBP3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBP3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZBP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM 1", "eco_id": "ECO_0000255", "start_pos": 62, "end_pos": 135, "start_aa": "Thr", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3ZBP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP3" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM 2", "eco_id": "ECO_0000255", "start_pos": 141, "end_pos": 226, "start_aa": "Thr", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 208 ], "sequon_annotation_sites": [ { "start_pos": 46, "end_pos": 48 }, { "start_pos": 47, "end_pos": 49 }, { "start_pos": 72, "end_pos": 74 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q58DA0-1", "uniprot_ac": "Q58DA0", "uniprot_id": "PSMD4_BOVIN", "mass": { "chemical_mass": 41384.0, "monoisotopic_mass": 41384.0 }, "refseq": { "ac": "NP_001013616", "name": "26S proteasome non-ATPase regulatory subunit 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013616" }, "gene_names": [ { "name": "PSMD4", "type": "recommended", "evidence": [ { "id": "Q58DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" } ] }, { "name": "PSMD4", "type": "synonym", "evidence": [ { "id": "NP_001013616", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013616" } ] } ], "protein_names": [ { "name": "26S proteasome non-ATPase regulatory subunit 4", "type": "recommended", "evidence": [ { "id": "Q58DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA0/entry#names_and_taxonomy" } ] }, { "name": "26S proteasome non-ATPase regulatory subunit 4", "type": "synonym", "evidence": [ { "id": "NP_001013616", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013616" } ] }, { "name": "26S proteasome regulatory subunit RPN10", "type": "synonym", "evidence": [ { "id": "NP_001013616", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013616" }, { "id": "Q58DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA0/entry#names_and_taxonomy" } ] }, { "name": "proteasome (prosome, macropain) 26S subunit, non-ATPase, 4", "type": "synonym", "evidence": [ { "id": "NP_001013616", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013616" } ] }, { "name": "proteasome 26S non-ATPase subunit 4", "type": "synonym", "evidence": [ { "id": "NP_001013616", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013616" } ] }, { "name": "proteasome 26S subunit, non-ATPase 4", "type": "synonym", "evidence": [ { "id": "NP_001013616", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013616" } ] } ], "function": [ { "annotation": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains.", "evidence": [ { "database": "UniProtKB", "id": "Q58DA0", "url": "https://www.uniprot.org/uniprotkb/Q58DA0#function" }, { "database": "UniProtKB", "id": "P55036", "url": "https://www.uniprot.org/uniprotkb/P55036#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DA0", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSMD4", "url": "https://www.uniprot.org/uniprotkb/Q58DA0", "locus": { "chromosome": "3", "start_pos": 19555256, "end_pos": 19565607, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006101", "url": "https://www.ensembl.org/id/ENSBTAG00000006101" } ] } } ], "crossref": [ { "id": "Q58DA0", "url": "https://alphafold.ebi.ac.uk/entry/Q58DA0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006101", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006101", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01452", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01452", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22297", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22297", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282016", "url": "https://www.ncbi.nlm.nih.gov/gene/282016", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027040", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027040", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282016", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282016", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DI44", "url": "https://www.orthodb.org/?gene=A0A452DI44", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q58DA0", "url": "https://www.orthodb.org/?gene=Q58DA0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10223", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10223", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10223:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10223:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02809", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02809", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13519", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13519", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9907900", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9907900", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001013616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013616", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DI44", "url": "https://www.uniprot.org/uniprotkb/A0A452DI44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DI44-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DI44-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3W4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3W4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3W4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3W4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1F0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1F0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1F0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1F0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DA0", "url": "https://www.uniprot.org/uniprotkb/Q58DA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DA0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DA0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEVLTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAAASAAEAGIATAGTEDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEFGQAESADMDASSAMDTSEPTKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLASQATKDGKKDKKEEDKKEEDKK", "length": 382, "header": "sp|Q58DA0-1|PSMD4_BOVIN Isoform 1 of 26S proteasome non-ATPase regulatory subunit 4 OS=Bos taurus OX=9913 GN=PSMD4 PE=2 SV=1 CANONICAL=Q58DA0-1" }, "isoforms": [ { "isoform_ac": "A0A452DI44-1", "url": "https://www.uniprot.org/uniprotkb/Q58DA0/entry#A0A452DI44-1", "sequence": { "sequence": "MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEVLTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAAASAAEAGIATAGTEDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEFGQAESADMDASSAMDTSEPTKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLASQATKDGKKDKKEEDKKEEDKKFFRVAALSDCIHFSWMYMYSGDVLQPHHFLVDGSGIASIVIFLV", "length": 426, "header": "tr|A0A452DI44-1|PSMD4_BOVIN Computationally mapped isoform of 26S proteasome non-ATPase regulatory subunit 4 OS=Bos taurus OX=9913 GN=PSMD4 PE=2 SV=2 CANONICAL=Q58DA0-1" }, "locus": { "chromosome": "3", "start_pos": 19565579, "end_pos": 19555257, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008019.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008019.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008019.7", "url": "https://www.ensembl.org/id/ENSBTAP00000008019.7" } ] } }, { "isoform_ac": "A0AAA9S3W4-1", "url": "https://www.uniprot.org/uniprotkb/Q58DA0/entry#A0AAA9S3W4-1", "sequence": { "sequence": "ACLSTTMIDNTKYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEVLTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAAASAAEAGIATAGTEDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEFGQAESADMDASSAMDTSEPTKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLASQATKDGKKDKKEEDKKEEDKK", "length": 380, "header": "tr|A0AAA9S3W4-1|PSMD4_BOVIN Computationally mapped isoform of 26S proteasome non-ATPase regulatory subunit 4 OS=Bos taurus OX=9913 GN=PSMD4 PE=2 SV=1 CANONICAL=Q58DA0-1" }, "locus": { "chromosome": "3", "start_pos": 19561661, "end_pos": 19556661, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092990.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092990.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078485.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078485.1" } ] } }, { "isoform_ac": "A0AAA9T1F0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DA0/entry#A0AAA9T1F0-1", "sequence": { "sequence": "MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEVLTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAAASAAEAGIATAGTEDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEFGQAESADMDASSAMDTSEPTKSSEKRSSCGGTLPSPTRACSAASPPHQADTDPVSGGG", "length": 358, "header": "tr|A0AAA9T1F0-1|PSMD4_BOVIN Computationally mapped isoform of 26S proteasome non-ATPase regulatory subunit 4 OS=Bos taurus OX=9913 GN=PSMD4 PE=2 SV=1 CANONICAL=Q58DA0-1" }, "locus": { "chromosome": "3", "start_pos": 19565579, "end_pos": 19556836, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092810.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092810.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091532.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091532.1" } ] } }, { "isoform_ac": "Q58DA0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DA0/entry#Q58DA0-1", "sequence": { "sequence": "MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEVLTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAAASAAEAGIATAGTEDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEFGQAESADMDASSAMDTSEPTKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLASQATKDGKKDKKEEDKKEEDKK", "length": 382, "header": "sp|Q58DA0-1|PSMD4_BOVIN Isoform 1 of 26S proteasome non-ATPase regulatory subunit 4 OS=Bos taurus OX=9913 GN=PSMD4 PE=2 SV=1 CANONICAL=Q58DA0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 250, "end_pos": 250, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q58DA0", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" } ], "site_lbl": "Thr250" }, { "start_pos": 253, "end_pos": 253, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q58DA0", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" } ], "site_lbl": "Thr253" }, { "start_pos": 256, "end_pos": 256, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DA0", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" } ], "site_lbl": "Ser256" }, { "start_pos": 266, "end_pos": 266, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DA0", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" } ], "site_lbl": "Ser266" }, { "start_pos": 358, "end_pos": 358, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DA0", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" } ], "site_lbl": "Ser358" }, { "start_pos": 361, "end_pos": 361, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DA0", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" } ], "site_lbl": "Ser361" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DA0", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:282016", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282016", "resource": "KEGG Pathway" }, { "id": "R-BTA-9907900", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9907900", "resource": "Reactome", "description": "Proteasome assembly" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "proteasome regulatory particle, base subcomplex", "id": "GO:0008540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008540", "evidence": [ { "database": "UniProtKB", "id": "Q58DA0", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" } ], "pmid": "" }, { "name": "proteasome accessory complex", "id": "GO:0022624", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022624", "evidence": [ { "database": "UniProtKB", "id": "Q58DA0", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q58DA0", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q58DA0", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" } ], "pmid": "" }, { "name": "proteasome complex", "id": "GO:0000502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000502", "evidence": [ { "database": "UniProtKB", "id": "Q58DA0", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "polyubiquitin modification-dependent protein binding", "id": "GO:0031593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031593", "evidence": [ { "database": "UniProtKB", "id": "Q58DA0", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q58DA0", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q58DA0", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DA0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 382, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DA0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DA0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" }, { "id": "PRU00213", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00213" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UIM 1", "eco_id": "ECO_0000255", "start_pos": 211, "end_pos": 230, "start_aa": "Ser", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" }, { "id": "PRU00213", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00213" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UIM 2", "eco_id": "ECO_0000255", "start_pos": 282, "end_pos": 301, "start_aa": "Thr", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA0" }, { "id": "PRU00219", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00219" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFA", "eco_id": "ECO_0000255", "start_pos": 5, "end_pos": 188, "start_aa": "Ser", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 250, 253, 256, 266, 358, 361 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "A6QP72-1", "uniprot_ac": "A6QP72", "uniprot_id": "DG2L6_BOVIN", "mass": { "chemical_mass": 38327.0, "monoisotopic_mass": 38327.0 }, "refseq": { "ac": "NP_001095331", "name": "diacylglycerol O-acyltransferase 2-like protein 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095331" }, "gene_names": [ { "name": "DGAT2L6", "type": "recommended", "evidence": [ { "id": "A6QP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP72" } ] }, { "name": "DGAT2L6", "type": "synonym", "evidence": [ { "id": "NP_001095331", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095331" } ] } ], "protein_names": [ { "name": "Diacylglycerol O-acyltransferase 2-like protein 6", "type": "recommended", "evidence": [ { "id": "A6QP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP72/entry#names_and_taxonomy" } ] }, { "name": "2.3.1.-", "type": "synonym", "evidence": [ { "id": "A6QP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP72/entry#names_and_taxonomy" } ] }, { "name": "diacylglycerol O-acyltransferase 2-like protein 6", "type": "synonym", "evidence": [ { "id": "NP_001095331", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095331" } ] } ], "function": [ { "annotation": "Diglyceride acyltransferase that uses fatty acyl-CoA as substrate. Particularly active with oleate as a substrate. Has no wax synthase activity to produce wax esters.", "evidence": [ { "database": "UniProtKB", "id": "A6QP72", "url": "https://www.uniprot.org/uniprotkb/A6QP72#function" }, { "database": "UniProtKB", "id": "Q6ZPD8", "url": "https://www.uniprot.org/uniprotkb/Q6ZPD8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QP72", "url": "https://www.uniprot.org/uniprotkb/A6QP72" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DGAT2L6", "url": "https://www.uniprot.org/uniprotkb/A6QP72", "locus": { "chromosome": "X", "start_pos": 80257128, "end_pos": 80278440, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007798", "url": "https://www.ensembl.org/id/ENSBTAG00000007798" } ] } } ], "crossref": [ { "id": "A6QP72", "url": "https://alphafold.ebi.ac.uk/entry/A6QP72", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007798", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007798", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07987", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07987", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505958", "url": "https://www.ncbi.nlm.nih.gov/gene/505958", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505958", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505958", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GTWIRFF", "url": "https://omabrowser.org/oma/group/GTWIRFF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DI75", "url": "https://www.orthodb.org/?gene=A0A452DI75", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A6QP72", "url": "https://www.orthodb.org/?gene=A6QP72", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12317", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12317", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12317:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12317:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03982", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03982", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1482883", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482883", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001095331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095331", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "38219", "url": "https://www.rhea-db.org/rhea/38219", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DI75", "url": "https://www.uniprot.org/uniprotkb/A0A452DI75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DI75-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DI75-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QP72", "url": "https://www.uniprot.org/uniprotkb/A6QP72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QP72-1", "url": "https://www.uniprot.org/uniprotkb/A6QP72-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFLSQLNLQEILQTLSVLQWMPVYVFLGAIPIIVIPYFLVFTKFWMVSVLALAWLAYDWNTHSQGGRRSAWVRNWTIWKYFQNYFPIKLVKTHDLSPRHNYIIASHPHGVLPYGTFINFATETTGFARIFPGITPYVATLEGIFWIPIVREYVMSMGVCPVSELALKYLLTQKGSGNAVVIMVGGGAEALLCHPGATTVLLKQRKGFVKVALETGAYLVPSYSFGQNEVHNQETFPEGTWKRFFQKALQDTLKKLLRLSVCTFHGRGLTRGSWGFLPFNHPITTVVGEPLPIPRIKKPNEETVDKYHALYINALQKLFDEHKVQYGLSETQELTII", "length": 337, "header": "sp|A6QP72-1|DG2L6_BOVIN Isoform 1 of Diacylglycerol O-acyltransferase 2-like protein 6 OS=Bos taurus OX=9913 GN=DGAT2L6 PE=2 SV=1 CANONICAL=A6QP72-1" }, "isoforms": [ { "isoform_ac": "A0A452DI75-1", "url": "https://www.uniprot.org/uniprotkb/A6QP72/entry#A0A452DI75-1", "sequence": { "sequence": "MAMAFLSQLNLQEILQTLSVLQWMPVYVFLGAIPIIVIPYFLVFTKFWMVSVLALAWLAYDWNTHSQGGRRSAWVRNWTIWKYFQNYFPIKLVKTHDLSPRHNYIIASHPHGVLPYGTFINFATETTGFARIFPGITPYVATLEGIFWIPIVREYVMSMGVCPVSELALKYLLTQKGSGNAVVIMVGGGAEALLCHPGATTVLLKQRKGFVKVALETGAYLVPSYSFGQNEVHNQETFPEGTWKRFFQKALQDTLKKLLRLSVCTFHGRGLTRGSWGFLPFNHPITTVVGEPLPIPRIKKPNEETVDKYHALYINALQKLFDEHKVQYGLSETQELTII", "length": 339, "header": "tr|A0A452DI75-1|DG2L6_BOVIN Computationally mapped isoform of Diacylglycerol O-acyltransferase 2-like protein 6 OS=Bos taurus OX=9913 GN=DGAT2L6 PE=2 SV=1 CANONICAL=A6QP72-1" }, "locus": { "chromosome": "X", "start_pos": 80278380, "end_pos": 80257591, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010259.6", "url": "https://www.ensembl.org/id/ENSBTAT00000010259.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010259.5", "url": "https://www.ensembl.org/id/ENSBTAP00000010259.5" } ] } }, { "isoform_ac": "A6QP72-1", "url": "https://www.uniprot.org/uniprotkb/A6QP72/entry#A6QP72-1", "sequence": { "sequence": "MAFLSQLNLQEILQTLSVLQWMPVYVFLGAIPIIVIPYFLVFTKFWMVSVLALAWLAYDWNTHSQGGRRSAWVRNWTIWKYFQNYFPIKLVKTHDLSPRHNYIIASHPHGVLPYGTFINFATETTGFARIFPGITPYVATLEGIFWIPIVREYVMSMGVCPVSELALKYLLTQKGSGNAVVIMVGGGAEALLCHPGATTVLLKQRKGFVKVALETGAYLVPSYSFGQNEVHNQETFPEGTWKRFFQKALQDTLKKLLRLSVCTFHGRGLTRGSWGFLPFNHPITTVVGEPLPIPRIKKPNEETVDKYHALYINALQKLFDEHKVQYGLSETQELTII", "length": 337, "header": "sp|A6QP72-1|DG2L6_BOVIN Isoform 1 of Diacylglycerol O-acyltransferase 2-like protein 6 OS=Bos taurus OX=9913 GN=DGAT2L6 PE=2 SV=1 CANONICAL=A6QP72-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:505958", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505958", "resource": "KEGG Pathway" }, { "id": "R-BTA-1482883", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482883", "resource": "Reactome", "description": "Acyl chain remodeling of DAG and TAG" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VSF3-1", "protein_name": "Acyltransferase", "gene_name": "DGAT2L6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTFISQLDLQEILQTFSVLQWVPCFAILGTIPIILIPYFLVFTKFWLVSVFALAWLFYDWNTPSQGGRRSDWIRNWTLWKYFRNYFPVKLVKTHDLSPKRNYIIANHPHGIVSYGIFVNFATEATGFAQLFPDITPYVGTLEVTFWIPILREYVMSMGVCPVSELSLKYLLTQRGSGNAVVVVVGGAAEALLCRPGASTILLKPRKGFVRLALETGSYLVPSYSFGENEVLNQESFAEGSWKSFFLKILQKALKKFMGLTFCIFHGRGLTKGSWGFLPFNRPITTVVGEPLPIPKIEKPTKETVDKYHALYISALRKLFDQHKTQYGLSETQELTII", "length": 337 }, "evidence": [ { "id": "A6QP72", "url": "https://omabrowser.org/oma/group/A6QP72/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7GJN5-1", "protein_name": "Acyltransferase", "gene_name": "Dgat2l6", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDEISYRARSSVLSPPPVVARLPLATDLQEGLRTLSVLQWIPVYVILGAIPILGIPYCLLFSSLWPLSVLPLIWLAYDWNTHSQDGRRSAWIRNWTLWKYFQSYFPVKLVKTHDLSPKHNYIIVSHPHGILAHGAFINFATEATGFSRIFPSITPCLATLEGIFWIPIVRDYVMSMGICPVSELALKYKLTQKGSGNAVIIVVGGASEALLCRPGASTVYLKNHKGFVKLALKTGAYLVPSYSFGENNIFNQETFPEGTWLRFFQKNFQKIGKKILGLNFCTFHGRGLTRTSWGFLPFNHPITTVVGEPLPVPKICDPDKETVAKYFEIYISALRKLFDQHKTKYGFSETQELTIV", "length": 356 }, "evidence": [ { "id": "A6QP72", "url": "https://omabrowser.org/oma/group/A6QP72/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A2ADU8-1", "protein_name": "Diacylglycerol O-acyltransferase 2-like protein 6", "gene_name": "Dgat2l6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAFSCLDLQEGLRTLSILQWIPVYVLLGTLSILGMPYLLLFTTLWPLSVLFLVWIAYDWNTHIQDGRRSAWVRNWTLWKYFQSYFPVKLVKTHDLSPKHNYIILSHPHGILSYGAFINFATESTGFSRVFPSITPFLATLEGIFWIPFVRDYLMSLGICPVSKLSLTHKLTQKDSGNAVIIVPGGASESLLSRPGVSMIYLKKRQGFVKLALKTGAYLVPSYSFGENETYNQETFAEGTWLRFFQKNIQKIGKRILGINLCTIHGRGLTRGSWGFLPFNHPITTVVGEPLPVPKIPDPDKETVEKYLELYISALRKLFDQHKAEYGLSKTHELKIL", "length": 337 }, "evidence": [ { "id": "A6QP72", "url": "https://omabrowser.org/oma/group/A6QP72/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZTG7-1", "protein_name": "Acyltransferase", "gene_name": "Dgat2l6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAFFSRLDLHEGLRTLSVLQWIPVYVILGTLSILGIPYFLLFSTFWPLSVLFLAWVAYDWNTHSQDGRRSAWVRNWTLWKYFQSYFPVKLVKTHDLSPKHNYIILSHPHGILCYGAFINFATEATGFSRVFPSITPFLATLEGIFWIPFVRDYVMSMGICPVSELALKHQLTQRGSGNAVIIVPGGASEALLCCPGVSTVYLKKRKGFVKLALKTGAYLVPSYSFGENEAYNQETFPEGTWLRFFQKNFQKIGKRILGINFCTFHGRGLTRGSWGFLPFNHPITTVVGEPLPVPKILDPDKETVAKYFELYISALRKLFDQHKTKYDFSKTQELTII", "length": 337 }, "evidence": [ { "id": "A6QP72", "url": "https://omabrowser.org/oma/group/A6QP72/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6ZPD8-1", "protein_name": "Diacylglycerol O-acyltransferase 2-like protein 6", "gene_name": "DGAT2L6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAFFSRLNLQEGLQTFFVLQWIPVYIFLGAIPILLIPYFLLFSKFWPLAVLSLAWLTYDWNTHSQGGRRSAWVRNWTLWKYFRNYFPVKLVKTHDLSPKHNYIIANHPHGILSFGVFINFATEATGIARIFPSITPFVGTLERIFWIPIVREYVMSMGVCPVSSSALKYLLTQKGSGNAVVIVVGGAAEALLCRPGASTLFLKQRKGFVKMALQTGAYLVPSYSFGENEVFNQETFPEGTWLRLFQKTFQDTFKKILGLNFCTFHGRGFTRGSWGFLPFNRPITTVVGEPLPIPRIKRPNQKTVDKYHALYISALRKLFDQHKVEYGLPETQELTIT", "length": 337 }, "evidence": [ { "id": "A6QP72", "url": "https://omabrowser.org/oma/group/A6QP72/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "A6QP72", "url": "https://www.uniprot.org/uniprotkb/A6QP72" } ], "pmid": "" }, { "name": "monoacylglycerol biosynthetic process", "id": "GO:0006640", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006640", "evidence": [ { "database": "UniProtKB", "id": "A6QP72", "url": "https://www.uniprot.org/uniprotkb/A6QP72" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A6QP72", "url": "https://www.uniprot.org/uniprotkb/A6QP72" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "O-acyltransferase activity", "id": "GO:0008374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008374", "evidence": [ { "database": "UniProtKB", "id": "A6QP72", "url": "https://www.uniprot.org/uniprotkb/A6QP72" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "38219", "name": "", "equation": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A6QP72-1", "F1N3U6-1", "F1MIW3-1", "Q70VZ8-1", "Q8MK44-1", "Q0VCR6-1" ], "evidence": [ { "id": "38219", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38219" } ] }, { "id": "R-BTA-8848580", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-1500596", "R-ALL-1500578" ], "output_participant_list": [ "R-ALL-1500594" ], "enzyme_list": [ "A6QP72-1" ], "evidence": [ { "id": "R-BTA-8848580", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8848580" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1500578", "participant_name": "acyl-CoA [cytosol]", "crossref": [ { "id": "58342", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1500594", "participant_name": "TAG [endoplasmic reticulum membrane]", "crossref": [ { "id": "17855", "database": "ChEBI", "url": "" }, { "id": "C00422", "database": "COMPOUND", "url": "" }, { "id": "8144567", "database": "PubChem Substance", "url": "" } ] }, { "participant_id": "R-ALL-1500596", "participant_name": "DAG [endoplasmic reticulum membrane]", "crossref": [ { "id": "17815", "database": "ChEBI", "url": "" }, { "id": "C00165", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A6QP72", "gene_name": "DGAT2L6", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "A6QP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP72" } ] } ] }, { "uniprot_ac": "F1MIW3", "gene_name": "DGAT1", "activity": [ { "ec_number": "2.3.1.20", "activity": "an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA.", "evidence": [ { "id": "F1MIW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIW3" } ] }, { "ec_number": "2.3.1.20", "activity": "", "evidence": [ { "id": "F1MIW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIW3" } ] } ] }, { "uniprot_ac": "F1N3U6", "gene_name": "UVRAG", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "F1N3U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3U6" } ] } ] }, { "uniprot_ac": "Q0VCR6", "gene_name": "TMEM68", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q0VCR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCR6" } ] }, { "ec_number": "2.3.1.20", "activity": "an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA.", "evidence": [ { "id": "Q0VCR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCR6" } ] }, { "ec_number": "2.3.1.22", "activity": "a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA.", "evidence": [ { "id": "Q0VCR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCR6" } ] } ] }, { "uniprot_ac": "Q70VZ8", "gene_name": "DGAT2", "activity": [ { "ec_number": "2.3.1.20", "activity": "an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA.", "evidence": [ { "id": "Q70VZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q70VZ8" } ] }, { "ec_number": "2.3.1.76", "activity": "all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA.", "evidence": [ { "id": "Q70VZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q70VZ8" } ] }, { "ec_number": "2.3.1.20", "activity": "", "evidence": [ { "id": "Q70VZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q70VZ8" } ] } ] }, { "uniprot_ac": "Q8MK44", "gene_name": "DGAT1", "activity": [ { "ec_number": "2.3.1.20", "activity": "an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA.", "evidence": [ { "id": "Q8MK44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MK44" } ] }, { "ec_number": "2.3.1.76", "activity": "all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA.", "evidence": [ { "id": "Q8MK44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MK44" } ] }, { "ec_number": "2.3.1.20", "activity": "", "evidence": [ { "id": "Q8MK44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MK44" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QP72-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 337, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QP72-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QP72" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 75, "end_pos": 77 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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"uniprot_id": "TMUB1_BOVIN", "mass": { "chemical_mass": 26206.0, "monoisotopic_mass": 26206.0 }, "refseq": { "ac": "NP_001029847", "name": "transmembrane and ubiquitin-like domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029847" }, "gene_names": [ { "name": "TMUB1", "type": "recommended", "evidence": [ { "id": "Q3ZBI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9" } ] }, { "name": "TMUB1", "type": "synonym", "evidence": [ { "id": "NP_001029847", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029847" } ] } ], "protein_names": [ { "name": "Transmembrane and ubiquitin-like domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q3ZBI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9/entry#names_and_taxonomy" } ] }, { "name": "transmembrane and ubiquitin-like domain-containing protein 1", "type": "synonym", "evidence": [ { "id": 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Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface. Acts as negative regulator of hepatocyte growth during regeneration.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9#function" }, { "database": "UniProtKB", "id": "Q9BVT8", "url": "https://www.uniprot.org/uniprotkb/Q9BVT8#function" }, { "database": "UniProtKB", "id": "Q53AQ4", "url": "https://www.uniprot.org/uniprotkb/Q53AQ4#function" }, { "database": "UniProtKB", "id": "Q9JMG3", "url": "https://www.uniprot.org/uniprotkb/Q9JMG3#function" } ] }, { "annotation": "May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation. May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9#function" }, { "database": "UniProtKB", "id": "Q9JMG3", "url": "https://www.uniprot.org/uniprotkb/Q9JMG3#function" }, { "database": "UniProtKB", "id": "A0A452DIJ0", "url": "https://www.uniprot.org/uniprotkb/A0A452DIJ0#function" }, { "database": "UniProtKB", "id": "ARBA00056835", "url": "https://www.uniprot.org/uniprotkb/ARBA00056835#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMUB1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9", "locus": { "chromosome": "4", "start_pos": 113656375, "end_pos": 113659123, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011229", "url": "https://www.ensembl.org/id/ENSBTAG00000011229" } ] } } ], "crossref": [ { "id": "Q3ZBI9", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBI9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011229", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011229", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17131", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17131", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539388", "url": "https://www.ncbi.nlm.nih.gov/gene/539388", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539388", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539388", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TLLWYCQ", "url": "https://omabrowser.org/oma/group/TLLWYCQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIJ0", "url": "https://www.orthodb.org/?gene=A0A452DIJ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBI9", "url": "https://www.orthodb.org/?gene=Q3ZBI9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14557", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14557", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14557:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14557:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029847", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DIJ0", "url": "https://www.uniprot.org/uniprotkb/A0A452DIJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBI9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALIEGVGDEVTILFSALACLLVLALAWVSTHTAEGADPLPQPSGTPTPTQPSEAMAVTDSIRGEAPGAETPGLRHRGQAAPPEPSVGLAATPPPPDSPQEPLVLRLKFLNDSEQVARAWPHDTIGSLKRTQFPGREQHVRLIYQGQLLGDDTQTLGSLHLPPNCVLHCHVSTRVGPPLPPCPPGSEPGPSGLEVGSLLLPLLLLLLLLLWYCQIQYRPFFPLTATLGLAGFTLLLSLLAFAMYRP", "length": 246, "header": "sp|Q3ZBI9-1|TMUB1_BOVIN Isoform 1 of Transmembrane and ubiquitin-like domain-containing protein 1 OS=Bos taurus OX=9913 GN=TMUB1 PE=2 SV=1 CANONICAL=Q3ZBI9-1" }, "isoforms": [ { "isoform_ac": "A0A452DIJ0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9/entry#A0A452DIJ0-1", "sequence": { "sequence": "MLRAAAAGKEGVPPGVCDLATSLPEVPEGPLWSWRSRALGSAAGKAGAMALIEGVGDEVTILFSALACLLVLALAWVSTHTAEGADPLPQPSGTPTPTQPSEAMAVTDSIRGEAPGAETPGLRHRGQAAPPEPSVGLAATPPPPDSPQEPLVLRLKFLNDSEQVARAWPHDTIGSLKRTQFPGREQHVRLIYQGQLLGDDTQTLGSLHLPPNCVLHCHVSTRVGPPLPPCPPGSEPGPSGLEVGSLLLPLLLLLLLLLWYCQIQYRPFFPLTATLGLAGFTLLLSLLAFAMYRP", "length": 294, "header": "tr|A0A452DIJ0-1|TMUB1_BOVIN Computationally mapped isoform of Transmembrane and ubiquitin-like domain-containing protein 1 OS=Bos taurus OX=9913 GN=TMUB1 PE=2 SV=1 CANONICAL=Q3ZBI9-1" }, "locus": { "chromosome": "4", "start_pos": 113658879, "end_pos": 113656839, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014915.4", "url": "https://www.ensembl.org/id/ENSBTAT00000014915.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014915.3", "url": "https://www.ensembl.org/id/ENSBTAP00000014915.3" } ] } }, { "isoform_ac": "Q3ZBI9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9/entry#Q3ZBI9-1", "sequence": { "sequence": "MALIEGVGDEVTILFSALACLLVLALAWVSTHTAEGADPLPQPSGTPTPTQPSEAMAVTDSIRGEAPGAETPGLRHRGQAAPPEPSVGLAATPPPPDSPQEPLVLRLKFLNDSEQVARAWPHDTIGSLKRTQFPGREQHVRLIYQGQLLGDDTQTLGSLHLPPNCVLHCHVSTRVGPPLPPCPPGSEPGPSGLEVGSLLLPLLLLLLLLLWYCQIQYRPFFPLTATLGLAGFTLLLSLLAFAMYRP", "length": 246, "header": "sp|Q3ZBI9-1|TMUB1_BOVIN Isoform 1 of Transmembrane and ubiquitin-like domain-containing protein 1 OS=Bos taurus OX=9913 GN=TMUB1 PE=2 SV=1 CANONICAL=Q3ZBI9-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 50, "start_aa": "Thr", "end_pos": 50, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr50", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 127, "end_pos": 127, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9" } ], "site_lbl": "Ser127" }, { "start_pos": 71, "end_pos": 71, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9" } ], "site_lbl": "Thr71" }, { "start_pos": 92, "end_pos": 92, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9" } ], "site_lbl": "Thr92" }, { "start_pos": 98, "end_pos": 98, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9" } ], "site_lbl": "Ser98" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539388", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539388", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AA58-1", "protein_name": "Transmembrane and ubiquitin-like domain-containing protein 1", "gene_name": "TMUB1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MALIEGVGDEVTALFALLLAVAVLALAWASTRAPEPVPPPRAAAPLPEEGPSAAPEPAVPHKAPASAPGGAGPDGAGGAAAALRARGGAGAPQQSPGGAAGGGPAEPTMVLRLKFLNDTERLARVRPGDTVGALKRAYFPGQEQQVRLIYQGQLLRDDAQSLAALHLAPNSVLHCHISQHSPAPAPAGPRASADPVHTALNVGSLMLPLFVLMLAVLWYFQLQYRHVFTATATTFLAGLTLLFSFMAFTMYRR", "length": 253 }, "evidence": [ { "id": "Q3ZBI9", "url": "https://omabrowser.org/oma/group/Q3ZBI9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HB66-1", "protein_name": "Transmembrane and ubiquitin-like domain-containing protein 1", "gene_name": "Tmub1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MALIEGVGDEVTVLFSVLACLLVLAVAWVSTHTTENTDPLPQTSGTTAPAQPSEAMAATDSIREEAPGAESPSLRHRGPSAQPEPDTGVTATTPPADSLQEPLVLRLKFLNDSEQVARAWPQDTIGSLKRTQFPGREQQVRLIYQGQLLGDDTQTLGSLHLPPNCVLHCHVSTRAGPPHPPCPPGSEPGPSGLEIGSLLLPLLLLLLLLLWYCQIQYRPFFPLTATLGLAGFTLLLSLLAFAMYRP", "length": 246 }, "evidence": [ { "id": "Q3ZBI9", "url": "https://omabrowser.org/oma/group/Q3ZBI9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q53AQ4-1", "protein_name": "Transmembrane and ubiquitin-like domain-containing protein 1", "gene_name": "Tmub1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALIEGVGDEVTVLFSVLACLLVLALAWVSTHTTESTDPLPQSSGTTTPAQPSEAMTAIDSIREEAPGAESPSLRHRGPSAQPEPEAGVTASTPPDSPQEPLLLRLKFLNDSEQVARAWPQDTIGSLKRTQFPGREQQVRLIYQGQLLGDDTQTLGSLHLPPNCVLHCHVSTRVGPPHPPCPPGSEPGPSGLEIGSLLLPLLLLLLLLLWYCQIQYRPFFPLTATLGLAGFTLLLSLLAFAMYRP", "length": 245 }, "evidence": [ { "id": "Q3ZBI9", "url": "https://omabrowser.org/oma/group/Q3ZBI9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6P135-1", "protein_name": "Transmembrane and ubiquitin-like domain-containing protein 1", "gene_name": "tmub1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MALIEGVGDEVTLLFGVVFLVLVLVLAWASTHTVEPPEHLLSPSPGASPSTETDSQEPLPPGNTDSSPGGVRDEDDKSEPGTEAGAAGQSADGSRAGGGDGGLLDDAGLGSDGLRHRESAGPSTHPPESTPSATQPSAEDAASDTHRNMVLRLKFLNDTERTAQVNPQDTIGYIKRTYFAGQEHQVRLIYQGQLLQDDSQTLASLNLADNSVLHCHISQHATRAMPAGARAADQVHVALNVGSLMVPLFVLMLSVLWYFQIQYRQFFTAPATASLVGITIFFSFVAFGVYRR", "length": 292 }, "evidence": [ { "id": "Q3ZBI9", "url": "https://omabrowser.org/oma/group/Q3ZBI9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9JMG3-1", "protein_name": "Transmembrane and ubiquitin-like domain-containing protein 1", "gene_name": "Tmub1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALIEGVGDEVTVLFAVLACLLVLALAWVSTHTTESTDPQPQPPGTTTPAQPSEAMSASDSIREEAPGAESPSLRHRGPSAQPEPDTGVTASTPPDSPQEPLLLRLKFLNDSEQVARAWPQDTIGSLKRTQFPGQEQQVRLIYQGQLLGDDTQTLGSLHLPPNCVLHCHVSTRVGPPHPPCPPGSEPGPSGLEIGSLLLPLLLLLLLLLWYCQIQYRPFFPLTATLGLAGFTLLLSLLAFAMYRP", "length": 245 }, "evidence": [ { "id": "Q3ZBI9", "url": "https://omabrowser.org/oma/group/Q3ZBI9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9" } ], "pmid": "" }, { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9" } ], "pmid": "" }, { "name": "recycling endosome", "id": "GO:0055037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ERAD pathway", "id": "GO:0036503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBI9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 246, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBI9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBI9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZBI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI9" }, { "id": "PRU00214", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00214" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubiquitin-like", "eco_id": "ECO_0000255", "start_pos": 103, "end_pos": 176, "start_aa": "Leu", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 50 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 71, 92, 98, 127 ], "sequon_annotation_sites": [ { "start_pos": 111, "end_pos": 113 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q58CV5-1", "uniprot_ac": "Q58CV5", "uniprot_id": "G6PT3_BOVIN", "mass": { "chemical_mass": 53454.0, "monoisotopic_mass": 53454.0 }, "refseq": { "ac": "NP_001019657", "name": "glucose-6-phosphate exchanger SLC37A2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019657" }, "gene_names": [ { "name": "SLC37A2", "type": "recommended", "evidence": [ { "id": "Q58CV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CV5" } ] }, { "name": "SLC37A2", "type": "synonym", "evidence": [ { "id": "NP_001019657", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019657" } ] } ], "protein_names": [ { "name": "Glucose-6-phosphate exchanger SLC37A2", "type": "recommended", "evidence": [ { "id": "Q58CV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CV5/entry#names_and_taxonomy" } ] }, { "name": "Solute carrier family 37 member 2", "type": "synonym", "evidence": [ { "id": "Q58CV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CV5/entry#names_and_taxonomy" } ] }, { "name": "glucose-6-phosphate exchanger SLC37A2", "type": "synonym", "evidence": [ { "id": "NP_001019657", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019657" } ] }, { "name": "solute carrier family 37 (glycerol-3-phosphate transporter), member 2", "type": "synonym", "evidence": [ { "id": "NP_001019657", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019657" } ] }, { "name": "sugar phosphate exchanger 2", "type": "synonym", "evidence": [ { "id": "NP_001019657", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019657" } ] } ], "function": [ { "annotation": "Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.", "evidence": [ { "database": "UniProtKB", "id": "A0A452DIQ9", "url": "https://www.uniprot.org/uniprotkb/A0A452DIQ9#function" }, { "database": "UniProtKB", "id": "ARBA00024304", "url": "https://www.uniprot.org/uniprotkb/ARBA00024304#function" }, { "database": "UniProtKB", "id": "A0A3Q1LYD9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYD9#function" }, { "database": "UniProtKB", "id": "A0A3Q1M1A8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1A8#function" }, { "database": "UniProtKB", "id": "Q58CV5", "url": "https://www.uniprot.org/uniprotkb/Q58CV5#function" }, { "database": "UniProtKB", "id": "Q8TED4", "url": "https://www.uniprot.org/uniprotkb/Q8TED4#function" } ] }, { "annotation": "Three novel mutations with very damaging effect on the protein structure, according to SIFT and Polyphen-2, were detected in GART, SHBG and SLC37A2 genes. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001019657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019657" }, { "database": "PubMed", "id": "23762392", "url": "https://glygen.org/publication/PubMed/23762392" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CV5", "url": "https://www.uniprot.org/uniprotkb/Q58CV5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC37A2", "url": "https://www.uniprot.org/uniprotkb/Q58CV5", "locus": { "chromosome": "29", "start_pos": 28523735, "end_pos": 28495844, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016704", "url": "https://www.ensembl.org/id/ENSBTAG00000016704" } ] } } ], "crossref": [ { "id": "Q58CV5", "url": "https://alphafold.ebi.ac.uk/entry/Q58CV5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016704", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016704", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17344", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17344", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506687", "url": "https://www.ncbi.nlm.nih.gov/gene/506687", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044740", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044740", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506687", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506687", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AMPYLID", "url": "https://omabrowser.org/oma/group/AMPYLID/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LYD9", "url": "https://www.orthodb.org/?gene=A0A3Q1LYD9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M1A8", "url": "https://www.orthodb.org/?gene=A0A3Q1M1A8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIQ9", "url": "https://www.orthodb.org/?gene=A0A452DIQ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q58CV5", "url": "https://www.orthodb.org/?gene=Q58CV5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43184", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43184", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43184:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43184:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70263", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001019657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019657", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "71535", "url": "https://www.rhea-db.org/rhea/71535", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LYD9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYD9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYD9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1A8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1A8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1A8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1A8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIQ9", "url": "https://www.uniprot.org/uniprotkb/A0A452DIQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CV5", "url": "https://www.uniprot.org/uniprotkb/Q58CV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CV5-1", "url": "https://www.uniprot.org/uniprotkb/Q58CV5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSSLAPGIWYRAFILLITFLIYTCYHMSRKPISVVKSRLHHNCSEVIQPVNSTHSLNDTTWCNWAPFDKSNYKELLGAVDNAFLVAYAIGMFISGIFGERLPLRYYLTAGMLLSGLFTSLFGLGYFWNIHVLWYFVLVQIFNGLVQTTGWPAVVSCVGNWFGKGKRGLIMGIWNSHTSVGNILGSLLAGVWVDQQWGLSFVVPGVITAIMGIITFFFLIEYPEDVDCSPPQHHGNPEESQDQPEDPANGPSCNKESSLESAVTCSKEASAQPSAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYISNVVHFTAKEAGDLSTLFDVGGIIGGILAGLVSDYINGRATTCCVMLILAAPMMFLYNHVGQRGIGISIVMLLICGALVNGPYALITTAVSADLGTHKSLKGNAKALSTVTAIIDGTGSIGAALGPLLAGLISPTGWNNVFYMLIAADVLACLLLCRLVYKEILAWKSSLSKDRGYREM", "length": 491, "header": "sp|Q58CV5-1|G6PT3_BOVIN Isoform 1 of Glucose-6-phosphate exchanger SLC37A2 OS=Bos taurus OX=9913 GN=SLC37A2 PE=2 SV=1 CANONICAL=Q58CV5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LYD9-1", "url": "https://www.uniprot.org/uniprotkb/Q58CV5/entry#A0A3Q1LYD9-1", "sequence": { "sequence": "SRNSEYRAFILLITFLIYTCYHMSRKPISVVKSRLHHNCSEVIQPVNSTHSLNDTTWCNWAPFDKSNYKELLGAVDNAFLVAYAIGMFISGIFGERLPLRYYLTAGMLLSGLFTSLFGLGYFWNIHVLWYFVLVQIFNGLVQTTGWPAVVSCVGNWFGKGKRGLIMGIWNSHTSVGNILGSLLAGVWVDQQWGLSFVVPGVITAIMGIITFFFLIEYPEDVDCSPPQHHGNPEESQDQPEDPANGPSCNKESSLESAVTCSKEASAQPSAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYISNVVHFTAKEAGDLSTLFDVGGIIGGILAGLVSDYINGRATTCCVMLILAAPMMFLYNHVGQRGIGISIVMLLICGALVNGPYALITTAVSADLGTHKSLKGNAKALSTVTAIIDGTGSIGAALGPLLAGLISPTGWNNVFYMLIAADVLACLLLCRLVYKEILAWKSSLSKDRG", "length": 482, "header": "tr|A0A3Q1LYD9-1|G6PT3_BOVIN Computationally mapped isoform of Glucose-6-phosphate exchanger SLC37A2 OS=Bos taurus OX=9913 GN=SLC37A2 PE=2 SV=2 CANONICAL=Q58CV5-1" }, "locus": { "chromosome": "29", "start_pos": 28520217, "end_pos": 28510455, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083825.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083825.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062264.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062264.2" } ] } }, { "isoform_ac": "A0A3Q1M1A8-1", "url": "https://www.uniprot.org/uniprotkb/Q58CV5/entry#A0A3Q1M1A8-1", "sequence": { "sequence": "MRSSLAPGIWFLRAFSRDSKYRAFILLITFLIYTCYHMSRKPISVVKSRLHHNCSEVIQPVNSTHSLNDTTWCNWAPFDKSNYKELLGAVDNAFLVAYAIGMFISGIFGERLPLRYYLTAGMLLSGLFTSLFGLGYFWNIHVLWYFVLVQIFNGLVQTTGWPAVVSCVGNWFGKGKRGLIMGIWNSHTSVGNILGSLLAGVWVDQQWGLSFVVPGVITAIMGIITFFFLIEYPEDVDCSPPQHHGNPEESQDQPEDPANGPSCNKESSLESAVTCSKEASAQPSAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYISNVVHFTAKEAGDLSTLFDVGGIIGGILAGLVSDYINGRATTCCVMLILAAPMMFLYNHVGQRGIGISIVMLLICGALVNGPYALITTAVSADLGTHKSLKGNAKALSTVTAIIDGTGSIGAALGPLLAGLISPTGWNNVFYMLIAADVLACLLLCRLVYKEILAWKSSLSKDRGSNVALTHA", "length": 505, "header": "tr|A0A3Q1M1A8-1|G6PT3_BOVIN Computationally mapped isoform of Glucose-6-phosphate exchanger SLC37A2 OS=Bos taurus OX=9913 GN=SLC37A2 PE=2 SV=1 CANONICAL=Q58CV5-1" }, "locus": { "chromosome": "29", "start_pos": 28520453, "end_pos": 28496043, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069229.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069229.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063485.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063485.1" } ] } }, { "isoform_ac": "A0A452DIQ9-1", "url": "https://www.uniprot.org/uniprotkb/Q58CV5/entry#A0A452DIQ9-1", "sequence": { "sequence": "MRSSLAPGIWFLRAFSRDSKYRAFILLITFLIYTCYHMSRKPISVVKSRLHHNCSEVIQPVNSTHSLNDTTWCNWAPFDKSNYKELLGAVDNAFLVAYAIGMFISGIFGERLPLRYYLTAGMLLSGLFTSLFGLGYFWNIHVLWYFVLVQIFNGLVQTTGWPAVVSCVGNWFGKGKRGLIMGIWNSHTSVGNILGSLLAGVWVDQQWGLSFVVPGVITAIMGIITFFFLIEYPEDVDCSPPQHHGNPEESQDQPEDPANGPSCNKESSLESAVTCSKEASAQPSAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYISNVVHFTAKEAGDLSTLFDVGGIIGGILAGLVSDYINGRATTCCVMLILAAPMMFLYNHVGQRGIGISIVMLLICGALVNGPYALITTAVSADLGTHKSLKGNAKALSTVTAIIDGTGSIGAALGPLLAGLISPTGWNNVFYMLIAADVLACLLLCRLVYKEILAWKSSLSKDRGYREM", "length": 501, "header": "tr|A0A452DIQ9-1|G6PT3_BOVIN Computationally mapped isoform of Glucose-6-phosphate exchanger SLC37A2 OS=Bos taurus OX=9913 GN=SLC37A2 PE=2 SV=1 CANONICAL=Q58CV5-1" }, "locus": { "chromosome": "29", "start_pos": 28522477, "end_pos": 28496043, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022208.8", "url": "https://www.ensembl.org/id/ENSBTAT00000022208.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022208.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022208.6" } ] } }, { "isoform_ac": "Q58CV5-1", "url": "https://www.uniprot.org/uniprotkb/Q58CV5/entry#Q58CV5-1", "sequence": { "sequence": "MRSSLAPGIWYRAFILLITFLIYTCYHMSRKPISVVKSRLHHNCSEVIQPVNSTHSLNDTTWCNWAPFDKSNYKELLGAVDNAFLVAYAIGMFISGIFGERLPLRYYLTAGMLLSGLFTSLFGLGYFWNIHVLWYFVLVQIFNGLVQTTGWPAVVSCVGNWFGKGKRGLIMGIWNSHTSVGNILGSLLAGVWVDQQWGLSFVVPGVITAIMGIITFFFLIEYPEDVDCSPPQHHGNPEESQDQPEDPANGPSCNKESSLESAVTCSKEASAQPSAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYISNVVHFTAKEAGDLSTLFDVGGIIGGILAGLVSDYINGRATTCCVMLILAAPMMFLYNHVGQRGIGISIVMLLICGALVNGPYALITTAVSADLGTHKSLKGNAKALSTVTAIIDGTGSIGAALGPLLAGLISPTGWNNVFYMLIAADVLACLLLCRLVYKEILAWKSSLSKDRGYREM", "length": 491, "header": "sp|Q58CV5-1|G6PT3_BOVIN Isoform 1 of Glucose-6-phosphate exchanger SLC37A2 OS=Bos taurus OX=9913 GN=SLC37A2 PE=2 SV=1 CANONICAL=Q58CV5-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 43, "start_aa": "Asn", "end_pos": 43, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn43", "evidence": [ { "id": "Q58CV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CV5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 52, "start_aa": "Asn", "end_pos": 52, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn52", "evidence": [ { "id": "Q58CV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CV5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 58, "start_aa": "Asn", "end_pos": 58, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn58", "evidence": [ { "id": "Q58CV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CV5#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CV5", "url": "https://www.uniprot.org/uniprotkb/Q58CV5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "Detection of haplotypes associated with prenatal death in dairy cattle and identification of deleterious mutations in GART, SHBG and SLC37A2.", "journal": "PloS one", "date": "2013", "authors": "Fritz S\u00e9bastien, Capitan Aurelien, Djari Anis, Rodriguez Sabrina C, Barbat Anne, Baur Aur\u00e9lia, Grohs C\u00e9cile, Weiss Bernard, Boussaha Mekki, Esquerr\u00e9 Diane, Klopp Christophe, Rocha Dominique, Boichard Didier", "evidence": [ { "database": "RefSeq", "id": "NP_001019657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019657" } ], "reference": [ { "type": "PubMed", "id": "23762392", "url": "https://glygen.org/publication/PubMed/23762392" } ] } ], "pathway": [ { "id": "bta:506687", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506687", "resource": "KEGG Pathway" }, { "id": "R-BTA-70263", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70263", "resource": "Reactome", "description": "Gluconeogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZSU5-1", "protein_name": "Coiled-coil domain containing 15", "gene_name": "CCDC15", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAMSRGVWGAGCCVPFPWGGLLLLFFGGSHFAKLPPPPTCAPFWLFPGCVPAPVPISSRHGSMGQRERGRLPGAASYGALPTHHTTALSCPGLPAWLRMHARMLRGEQARSRARMLPSSRLRPRAPRGAVGRPARPPRTGRALLGERSLRVAPVGAWVESGPREQSRAFASAFQVEEELKEQQRRKAMRLRHFQGEVKRRVNQQVKMRRKQQLQRSCEAVEKESNLAVQCSGSVLHLTPKKNTCVFRSCPVPAICSSSAHAALAQQQEQGVPSEPFQQQAAQLSKAMRQVRRRLASCRTVPKGTEVPELPGGTWTLGQKQDQSVLYAPVPTEGENEELILAGHHDLPAELQDQMTAPHQAEQDDDFYIKMEFRQFSNGSVKDLSPPESLQRTTLGCQAPLVLWAGIDQEESKKQRQNEYLRCRRLFMSAEREQVKEQQRQKERQKRIAEIKSKKENQRQVEEQRMQEVAKQQEPFLGESVCEILAQLELEERRLKKVKQKEQRNKEYTRYVEALRAEVKEKMKLYNIDLPPLCSCSSDFWESHPTTCANNCIFYKNHKAYSHALQSVISSCDLVDGRPKLPLRHLAALCTCPAKL", "length": 596 }, "evidence": [ { "id": "Q58CV5", "url": "https://omabrowser.org/oma/group/Q58CV5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0LFP4-1", "protein_name": "Solute carrier family 37 member 2", "gene_name": "Slc37a2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLNFWAPPKHTRRLFQALDLCLFPNNNLTHAPTYFPHLLRLSADILSTKKHSLLFNAHQHPAPPAPASWMKKSMPGGMTPLKKPRNPTKLPLTLNPTKSKDVLAVLAERNQAIVPVGAWVEPASPNWSGIPAHTSAYILEEEIKEQQRRKQESLRHFQRQVKHRVNQQAKLRKKQQLDKSYKAAEKEGSIAIRYSDSAHLTSKRTSVFPRNLNAAVGSFRLPTSLVLGNATDDAENQNQLFEQQAQALSQTMKQARHQLASFKTVSEKKTSVFLNGGKKSSPTQEDLGCGKISSVVVSEERDNLFESCQQDLLSEDKEKALSKVQKVKFKNPLSVVIKEDEGKQLYPHSLQPVLPEAQGYFVEVKSCLPESQSDVIDVQAVEPKASRIEPKEPGGEPDTQAAGMEFQTTEPDGQAVKTEIQDTLKVQTVELDGDTELEAQDSLPSHQAFLSRDQDFLLNCQYQGSLPKDHCVLPNYQNVLPKYQDQHFLPVAQEFLPTNQLALPKEQNHPLKCQKQDLPPEDQFPLPRHQYILPIYQDRRDPHVLPKCQDHDVLSKAQNYLHSYQEQDLPLQSQSQQPSVRTAERWQEDLYLSGHECLPPRQRRDTCSRRQQLCEEYRSGPSTEQQALLPFQSGVDQEEDKKERQKQYLRHRRIFMDIEREQVKEQNRQREQKRRAEKIKKRKEQERYAEEQRLLRVNCPEEPCSEENISDVLAQLQLQEIKGAREKQQQREKEYVRYVEALRAQVQEKMKLYNITLPPLCCCGPDFWDAHPDTCANNCIFYKNYRAYNRALHSVINSSDISEGNATLRNAIRNFASAHRRNFKTKSPVRG", "length": 831 }, "evidence": [ { "id": "Q58CV5", "url": "https://omabrowser.org/oma/group/Q58CV5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8MLW5-1", "protein_name": "Major facilitator superfamily transporter 16, isoform B", "gene_name": "MFS16", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MRTSEQKSSWHYSQPKRIREPSHLDEQHLHLAHCPRRSMRASLGLGRTRKMSNNYNDVPFGIRAVQRLSRQCCTRFHARRDLLYKMSVFVLTFLAYACYHMCRKPISVVKSVLQGNCSTALAASGQDCGYAPFDVPDATTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNIHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESDWALSFVVPGIIIAAVGFLLFLFLVDQPEIVGCYPQAGQHERRVANESDVEQDDEEQVRHNDAEINYRSAPTERTPILPRSQPEAVPRGRGRPISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQQYGALSMTISIVLLIVVGIFVNGPYALITTSVSAELGQHSSLEGNANALATVTAIIDGTGSIGAAVGPLLAGLISTAGWQYVFHMLIAADIIAMVLLGRLVFKEFAALRRASHRIRIE", "length": 566 }, "evidence": [ { "id": "Q58CV5", "url": "https://omabrowser.org/oma/group/Q58CV5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q8TED4-1", "protein_name": "Glucose-6-phosphate exchanger SLC37A2", "gene_name": "SLC37A2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRSSLAPGVWFFRAFSRDSWFRGLILLLTFLIYACYHMSRKPISIVKSRLHQNCSEQIKPINDTHSLNDTMWCSWAPFDKDNYKELLGGVDNAFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGYFWNIHELWYFVVIQVCNGLVQTTGWPSVVTCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGIWVNGQWGLSFIVPGIITAVMGVITFLFLIEHPEDVDCAPPQHHGEPAENQDNPEDPGNSPCSIRESGLETVAKCSKGPCEEPAAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYIANVAHFSAKEAGDLSTLFDVGGIIGGIVAGLVSDYTNGRATTCCVMLILAAPMMFLYNYIGQDGIASSIVMLIICGGLVNGPYALITTAVSADLGTHKSLKGNAKALSTVTAIIDGTGSIGAALGPLLAGLISPTGWNNVFYMLISADVLACLLLCRLVYKEILAWKVSLSRGSGYKEI", "length": 501 }, "evidence": [ { "id": "Q58CV5", "url": "https://omabrowser.org/oma/group/Q58CV5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9SL56-1", "protein_name": "Putative glycerol-3-phosphate transporter 5", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MQSRIVGLAPAFSLFPNLNTPHKTFTFHQILVLIITFTAYASFHASRKPPSIVKSVLGPPSLNSSSIDNGWAPFNGTQGTKRLGELDLAFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLGYWMNVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGNWCGKEKRGLIMGLWNSHTSVGNILGSVIASSVLDFGWGWSFVLPGVLVLVSGVVVFMFLVVSPNDLGFEELGKEIEIEMSLGENVEESLRKHEAEGAVLLENVDDSSFAIGFLEAWRLPGVAPYAFCLFFSKLVAYTFLYWLPYYLRHTAVAGVNLSHKTAGILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMYRVYGSVSMFINIVLMFISGLLVNGPYALITTAVAADLGTQDSIKGNGRALATVTAIIDGTGSVGAALGPLLAGYISSRGWNSVFFMLIVSIFFAGLFLVRLAKSEINTMRSGELIASSVP", "length": 493 }, "evidence": [ { "id": "Q58CV5", "url": "https://omabrowser.org/oma/group/Q58CV5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9WU81-1", "protein_name": "Glucose-6-phosphate exchanger SLC37A2", "gene_name": "Slc37a2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRSSLAPGVWFLRAFSRDSWFRGFILLLTFLIYACYHMSRKPISIVKSRLHQNCSEMVRPVNDTHDLNDTTWCSWSPFDKDDYKELLGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGYFWNIHMLWYFVLIQICNGLVQTTGWPSVVTCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGVWVNQHWGLSFIVPGIITAIMGVITFLFLIEYPEDVDCTPPRHHDDPEKEQDNPEDPVNSPYSSRESNVDIAASSSKEQGPEPEAISFLGALRIPGVIEFSLCLLFAKLVSYTFLYWLPLYIFNVAHFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTNSRATTCCIMLILAAPMMFLYNYIGQNGITSSIVMLIICGVLVNGPYALITTAVSADLGTHESLKGNAKALSTVTAIIDGTGSIGAALGPLLAGLISPTGWNNVFYMLISADVLACLLLCRLVYKEILAWKTACGRSSGYKQI", "length": 501 }, "evidence": [ { "id": "Q58CV5", "url": "https://omabrowser.org/oma/group/Q58CV5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q58CV5", "url": "https://www.uniprot.org/uniprotkb/Q58CV5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "glucose-6-phosphate transport", "id": "GO:0015760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015760", "evidence": [ { "database": "UniProtKB", "id": "Q58CV5", "url": "https://www.uniprot.org/uniprotkb/Q58CV5" } ], "pmid": "" }, { "name": "phosphate ion transmembrane transport", "id": "GO:0035435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035435", "evidence": [ { "database": "UniProtKB", "id": "Q58CV5", "url": "https://www.uniprot.org/uniprotkb/Q58CV5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "glucose 6-phosphate:phosphate antiporter activity", "id": "GO:0061513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061513", "evidence": [ { "database": "UniProtKB", "id": "Q58CV5", "url": "https://www.uniprot.org/uniprotkb/Q58CV5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" }, { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" }, { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "71535", "name": "", "equation": "D-glucose 6-phosphate(in) + phosphate(out) = D-glucose 6-phosphate(out) + phosphate(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "71535", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/71535" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CV5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 491, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CV5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CV5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 43, 52, 58 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 43, "end_pos": 45 }, { "start_pos": 52, "end_pos": 54 }, { "start_pos": 58, "end_pos": 60 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", 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This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q58CU0", "url": "https://www.uniprot.org/uniprotkb/Q58CU0#function" }, { "database": "UniProtKB", "id": "Q9HAF1", "url": "https://www.uniprot.org/uniprotkb/Q9HAF1#function" }, { "database": "UniProtKB", "id": "A0A452DJH1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJH1#function" }, { "database": "UniProtKB", "id": "RU368022", "url": "https://www.uniprot.org/uniprotkb/RU368022#function" }, { "database": "UniProtKB", "id": "ARBA00046129", "url": "https://www.uniprot.org/uniprotkb/ARBA00046129#function" }, { "database": "UniProtKB", "id": "A0AAA9S9Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y9#function" }, { "database": "UniProtKB", "id": "A0AAA9TAJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAJ8#function" }, { "database": "UniProtKB", "id": "F6QQH9", "url": "https://www.uniprot.org/uniprotkb/F6QQH9#function" } ] } ], "disease": 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"R-BTA-3214847", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214847", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6804758", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804758", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005204893", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204893", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DJH1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJH1-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9Y9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Y9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": 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"https://www.ensembl.org/id/ENSBTAT00000126118.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080240.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080240.1" } ] } }, { "isoform_ac": "A0AAA9TAJ8-1", "url": "https://www.uniprot.org/uniprotkb/Q58CU0/entry#A0AAA9TAJ8-1", "sequence": { "sequence": "MRAGGSGLSERLGSKRAGRVEEIGSGLAVGSGEETLANLERQIYAFEGSYLEDTQMYGNIIRGWDRYLTNQKNSNSKNDRRNRKFKEAERLFSKSSVTSAAAVSALAGVQDQLIEKREPGSGTESDTSPDFHNQENEPNQEDPEDLDGSVQGVKPQKAASSTSTGSHHSSHKKRKNKNRHRIDLKLNKKPRADY", "length": 194, "header": "tr|A0AAA9TAJ8-1|EAF6_BOVIN Computationally mapped isoform of Chromatin modification-related protein MEAF6 OS=Bos taurus OX=9913 GN=MEAF6 PE=2 SV=1 CANONICAL=Q58CU0-1" }, "locus": { "chromosome": "3", "start_pos": 108392991, "end_pos": 108368566, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132609.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132609.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093907.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093907.1" } ] } }, { "isoform_ac": "F6QQH9-1", "url": "https://www.uniprot.org/uniprotkb/Q58CU0/entry#F6QQH9-1", "sequence": { "sequence": "MAMHNKAAPPQIPDTRRELAELVKRKQELAETLANLERQIYAFEGSYLEDTQMYGNIIRGWDRYLTNQKNSNSKNDRRNRKFKEAERLFSKSSVTSAAAVSALAGVQDQLIEKREPGSGTESDTSPDFHNQENEPNQEDPEDLDGSVQGVKPQKAASSTSTGSHHSSHKKRKNKNRHSPSGMFDYDFEYVY", "length": 191, "header": "tr|F6QQH9-1|EAF6_BOVIN Computationally mapped isoform of Chromatin modification-related protein MEAF6 OS=Bos taurus OX=9913 GN=MEAF6 PE=2 SV=2 CANONICAL=Q58CU0-1" }, "locus": { "chromosome": "3", "start_pos": 108391781, "end_pos": 108368140, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033241.6", "url": "https://www.ensembl.org/id/ENSBTAT00000033241.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033161.5", "url": "https://www.ensembl.org/id/ENSBTAP00000033161.5" } ] } }, { "isoform_ac": "Q58CU0-1", "url": "https://www.uniprot.org/uniprotkb/Q58CU0/entry#Q58CU0-1", "sequence": { "sequence": "MAMHNKAAPPQIPDTRRELAELVKRKQELAETLANLERQIYAFEGSYLEDTQMYGNIIRGWDRYLTNQKNSNSKNDRRNRKFKEAERLFSKSSVTSAAAVSALAGVQDQLIEKREPGSGTESDTSPDFHNQENEPNQEDPEDLDGSVQGVKPQKAASSTSTGSHHSSHKKRKNKNRHRIDLKLNKKPRADY", "length": 191, "header": "sp|Q58CU0-1|EAF6_BOVIN Isoform 1 of Chromatin modification-related protein MEAF6 OS=Bos taurus OX=9913 GN=MEAF6 PE=2 SV=2 CANONICAL=Q58CU0-1" }, "locus": {} }, { "isoform_ac": "Q58CU0-2", "url": "https://www.uniprot.org/uniprotkb/Q58CU0/entry#Q58CU0-2", "sequence": { "sequence": "MYGNIIRGWDRYLTNQKNSNSKNDRRNRKFKEAERLFSKSSVTSAAAVSALAGVQDQLIEKREPGSGTESDTSPDFHNQENEPNQEDPEDLDGSVQGVKPQKAASSTSTGSHHSSHKKRKNKNRHSPSGMFDYDFEIDLKLNKKPRADY", "length": 149, "header": "sp|Q58CU0-2|EAF6_BOVIN Isoform 2 of Chromatin modification-related protein MEAF6 OS=Bos taurus OX=9913 GN=MEAF6 PE=2 SV=2 CANONICAL=Q58CU0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 118, "end_pos": 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0Y3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0Y3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0Y3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIY4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXP8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXP8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA24", "url": "https://www.uniprot.org/uniprotkb/Q5EA24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA24-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA24-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPKKARPAGDGKEQGPAPKQVKVEAACGPSSPLNFDSPSGLFESFISPIKTETFFKEFWEQKPLLIQRDDPALATYYQSLFRLSDLKSLCSWGIYYGRDVNVCRCVHGKKKVLNKDGRVHFLQLRQDFDQKRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGAQGLPPHYDDVEVFILQLEGEKHWRLYQPTVPLAREYSVEAEDRIGRPTHEFTLKPGDLLYFPRGTIHQADTPEGLAHSTHVTISTYQSSSWGDFLLDTISGLVFDTAKADVALRAGIPRQLLLQAESIAVATRLSGFLRMLADRLEGTKELPSADMKKDFAMNRLPPYYMGDRAKLVAPGGQLPGLDSTVRLQFRDHVVLTVGPYQDPSDETRGEMVYVYHSLRNRRDTHMMGNETESYGLRFPLSYMDALKQIWNSSAISVKDLKLTTDEEKQNLVLSLWTECLIQVV", "length": 462, "header": "sp|Q5EA24-1|RIOX2_BOVIN Isoform 1 of Ribosomal oxygenase 2 OS=Bos taurus OX=9913 GN=RIOX2 PE=2 SV=1 CANONICAL=Q5EA24-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MI23-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA24/entry#A0A3Q1MI23-1", "sequence": { "sequence": "MPKKARPAGDGKEQGPAPKQVKVEAACGPSSPLNFDSPSGLFESFISPIKTETFFKEFWEQKPLLIQRDDPALATYYQSLFRLSDLKSLCSWGIYYGRDVNVCRCVHGKKKVLNKDGRVHFLQLRQDFDQKRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGAQGLPPHYDDVEVFILQLEGEKHWRLYQPTVPLAREYSVEAEDRIGRPTHEFTLKPGDLLYFPRGTIHQADTPEGLAHSTHVTISTYQSSSWGDFLLDTISGLVFDTAKADVALRAGIPRQLLLQAESIAVATRLSGFLRMLADRLEGTKELPSADMKKDFAMNRLPPYYMGDRAKLVAPGGQLPGLDSTVRLQFRDHVVLTVGPYQDPSDETRGEMVYVYHSLRNRRDTHMMGNETESYGLRFPLSYMDALKQIWNSSAISVKDLKLTTDEEKQNLGFFYPGGGGGLEFKMNIQGHNTLAFVIGLPLTSRTS", "length": 485, "header": "tr|A0A3Q1MI23-1|RIOX2_BOVIN Computationally mapped isoform of Ribosomal oxygenase 2 OS=Bos taurus OX=9913 GN=RIOX2 PE=2 SV=1 CANONICAL=Q5EA24-1" }, "locus": { "chromosome": "1", "start_pos": 42223912, "end_pos": 42195183, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070121.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070121.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070898.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070898.1" } ] } }, { "isoform_ac": "A0A452DJI2-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA24/entry#A0A452DJI2-1", "sequence": { "sequence": "MPKKARPAGDGKEQGPAPKQVKVEAACGPSSPLNFDSPSGLFESFISPIKTETFFKEFWEQKPLLIQRDDPALATYYQSLFRLSDLKSLCSWGIYYGRDVNVCRCVHGKKKVLNKDGRVHFLQLRQDFDQKRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGAQGLPPHYDDVEVFILQLEGEKHWRLYQPTVPLAREYSVEAEDRIGRPTHEFTLKPGDLLYFPRGTIHQADTPEGLAHSTHVTISTYQTLLRAVVPDSLLCFQQAESIAVATRLSGFLRMLADRLEGTKELPSADMKKDFAMNRLPPYYMGDRAKLVAPGGQLPGLDSTVRLQFRDHVVLTVGPYQDPSDETRGEMVYVYHSLRNRRDTHMMGNETESYGLRFPLSYMDALKQIWNSSAISVKDLKLTTDEEKQNLVLSLWTECLIQVV", "length": 441, "header": "tr|A0A452DJI2-1|RIOX2_BOVIN Computationally mapped isoform of Ribosomal oxygenase 2 OS=Bos taurus OX=9913 GN=RIOX2 PE=2 SV=1 CANONICAL=Q5EA24-1" }, "locus": { "chromosome": "1", "start_pos": 42223912, "end_pos": 42197906, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020656.4", "url": "https://www.ensembl.org/id/ENSBTAT00000020656.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020656.3", "url": "https://www.ensembl.org/id/ENSBTAP00000020656.3" } ] } }, { "isoform_ac": "A0AAA9S0Y3-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA24/entry#A0AAA9S0Y3-1", "sequence": { "sequence": "MRAPRRAAPGWRSRPLRWRPRASGLNPVSASVPAWRPPLGCLGWCSFSRRPSAIVGGARAGFACPHCLVLKTAMPKKARPAGDGKEQGPAPKQVKVEAACGPSSPLNFDSPSGLFESFISPIKTETFFKEFWEQKPLLIQRDDPALATYYQSLFRLSDLKSLCSWGIYYGRDVNVCRCVHGKKKVLNKDGRVHFLQLRQDFDQKRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGAQGLPPHYDDVEVFILQLEGEKHWRLYQPTVPLAREYSVEAEDRIGRPTHEFTLKPGDLLYFPRGTIHQADTPEGLAHSTHVTISTYQSSSWGDFLLDTISGLVFDTAKADVALRAGIPRQLLLQAESIAVATRLSGFLRMLADRLEGTKELPSADMKKDFAMNRLPPYYMGDRAKLVAPGGQLPGLDSTVRLQFRDHVVLTVGPYQDPSDETRGEMVYVYHSLRNRRDTHMMGNETESYGLRFPLSYMDALKQIWNSSAISVKDLKLTTDEEKQNLVLSLWTECLIQVV", "length": 535, "header": "tr|A0AAA9S0Y3-1|RIOX2_BOVIN Computationally mapped isoform of Ribosomal oxygenase 2 OS=Bos taurus OX=9913 GN=RIOX2 PE=2 SV=1 CANONICAL=Q5EA24-1" }, "locus": { "chromosome": "1", "start_pos": 42230818, "end_pos": 42197906, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113470.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113470.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075737.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075737.1" } ] } }, { "isoform_ac": "A0AAA9TIY4-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA24/entry#A0AAA9TIY4-1", "sequence": { "sequence": "MASHSSTLAWKIPWTEEPGGLQSMGPLRVRHEFACPHCLVLKTAMPKKARPAGDGKEQGPAPKQVKVEAACGPSSPLNFDSPSGLFESFISPIKTETFFKEFWEQKPLLIQRDDPALATYYQSLFRLSDLKSLCSWGIYYGRDVNVCRCVHGKKKVLNKDGRVHFLQLRQDFDQKRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGAQGLPPHYDDVEVFILQLEGEKHWRLYQPTVPLAREYSVEAEDRIGRPTHEFTLKPGDLLYFPRGTIHQADTPEGLAHSTHVTISTYQSSSWGDFLLDTISGLVFDTAKADVALRAGIPRQLLLQAESIAVATRLSGFLRMLADRLEGTKELPSADMKKDFAMNRLPPYYMGDRAKLVAPGGQLPGLDSTVRLQFRDHVVLTVGPYQDPSDETRGEMVYVYHSLRNRRDTHMMGNETESYGLRFPLSYMDALKQIWNSSAISVKDLKLTTDEEKQNLVLSLWTECLIQVV", "length": 506, "header": "tr|A0AAA9TIY4-1|RIOX2_BOVIN Computationally mapped isoform of Ribosomal oxygenase 2 OS=Bos taurus OX=9913 GN=RIOX2 PE=2 SV=1 CANONICAL=Q5EA24-1" }, "locus": { "chromosome": "1", "start_pos": 42228618, "end_pos": 42197906, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096052.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096052.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096868.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096868.1" } ] } }, { "isoform_ac": "A0AAA9TXP8-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA24/entry#A0AAA9TXP8-1", "sequence": { "sequence": "MRSHSRQPCYRFACPHCLVLKTAMPKKARPAGDGKEQGPAPKQVKVEAACGPSSPLNFDSPSGLFESFISPIKTETFFKEFWEQKPLLIQRDDPALATYYQSLFRLSDLKSLCSWGIYYGRDVNVCRCVHGKKKVLNKDGRVHFLQLRQDFDQKRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGAQGLPPHYDDVEVFILQLEGEKHWRLYQPTVPLAREYSVEAEDRIGRPTHEFTLKPGDLLYFPRGTIHQADTPEGLAHSTHVTISTYQSSSWGDFLLDTISGLVFDTAKADVALRAGIPRQLLLAESIAVATRLSGFLRMLADRLEGTKELPSADMKKDFAMNRLPPYYMGDRAKLVAPGGQLPGLDSTVRLQFRDHVVLTVGPYQDPSDETRGEMVYVYHSLRNRRDTHMMGNETESYGLRFPLSYMDALKQIWNSSAISVKDLKLTTDEEKQNLVLSLWTECLIQVV", "length": 484, "header": "tr|A0AAA9TXP8-1|RIOX2_BOVIN Computationally mapped isoform of Ribosomal oxygenase 2 OS=Bos taurus OX=9913 GN=RIOX2 PE=2 SV=1 CANONICAL=Q5EA24-1" }, "locus": { "chromosome": "1", "start_pos": 42228419, "end_pos": 42197906, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114951.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114951.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102257.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102257.1" } ] } }, { "isoform_ac": "Q5EA24-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA24/entry#Q5EA24-1", "sequence": { "sequence": "MPKKARPAGDGKEQGPAPKQVKVEAACGPSSPLNFDSPSGLFESFISPIKTETFFKEFWEQKPLLIQRDDPALATYYQSLFRLSDLKSLCSWGIYYGRDVNVCRCVHGKKKVLNKDGRVHFLQLRQDFDQKRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGAQGLPPHYDDVEVFILQLEGEKHWRLYQPTVPLAREYSVEAEDRIGRPTHEFTLKPGDLLYFPRGTIHQADTPEGLAHSTHVTISTYQSSSWGDFLLDTISGLVFDTAKADVALRAGIPRQLLLQAESIAVATRLSGFLRMLADRLEGTKELPSADMKKDFAMNRLPPYYMGDRAKLVAPGGQLPGLDSTVRLQFRDHVVLTVGPYQDPSDETRGEMVYVYHSLRNRRDTHMMGNETESYGLRFPLSYMDALKQIWNSSAISVKDLKLTTDEEKQNLVLSLWTECLIQVV", "length": 462, "header": "sp|Q5EA24-1|RIOX2_BOVIN Isoform 1 of Ribosomal oxygenase 2 OS=Bos taurus OX=9913 GN=RIOX2 PE=2 SV=1 CANONICAL=Q5EA24-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 169, "start_aa": "Thr", "end_pos": 169, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr169", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 308, "end_pos": 308, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA24", "url": "https://www.uniprot.org/uniprotkb/Q5EA24" } ], "site_lbl": "Ser308" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA24", "url": "https://www.uniprot.org/uniprotkb/Q5EA24" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:540466", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540466", "resource": "KEGG Pathway" }, { "id": "R-BTA-3214842", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214842", "resource": "Reactome", "description": "HDMs demethylate histones" }, { "id": "R-BTA-9629569", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9629569", "resource": "Reactome", "description": "Protein hydroxylation" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8CD15-1", "protein_name": "Ribosomal oxygenase 2", "gene_name": "Riox2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKKVQPTGDENEEASVPCKRVKEELPETLSVLNFDSPSSFFESLISPIKVETFFKEFWEQKPLLIQRDDPVLAKYYQSLFSLSDLKRLCKKGVYYGRDVNVCRSISGKKKVLNKDGRAHFLQLRKDFDQKRATIQFHQPQRYKDELWRIQEKLECYFGSLVGSNVYMTPAGSQGLPPHYDDVEVFILQLEGTKHWRLYSPTVPLAHEYSVESEDRIGTPTHDFLLKPGDLLYFPRGTIHQAETPSGLAYSIHLTISTYQNNSWGDCLLDSISGFVFDIAKEDVALRSGMPRRMLLNVETPADVTRKLSGFLRTLADQLEGREELLSSDMKKDFVKHRLPPFFEGNGTETMDPGKQLPRLDNIIRLQFKDHIVLTVGPDKNPFDEAQQKVVYIYHSLKNVRQMHMIGEEEESEIFGLRFPLSHVDALKQIWCGSPIRVKDLKLDTDEEKENLALSLWSESLIQVL", "length": 465 }, "evidence": [ { "id": "Q5EA24", "url": "https://omabrowser.org/oma/group/Q5EA24/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8CFC1-1", "protein_name": "Ribosomal oxygenase 2", "gene_name": "Riox2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKKVKPTGDENEEESVPCKQVKEELPNTLSVLNFDSPSSFFESLISPIKVETFFKEFWEQKPLLIQRDDPSLAAYYQSLFSLSDLRSLCSQGLYYGRDVNVCRCIGGKKKVLNKDGKAQFLQLRKDFDQKRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYMTPAGSQGLPPHYDDVEVFILQLEGRKRWRLYSPTVPLAREYSVEPEDRIGTPTHDFLLKPGDLLYFPRGTIHQAETPSGLAHSIHLTISTYQNNSWGDYLLDSISGLVFDIAKEDVALRTGMPRRMLMNVETPADVTRKLSGFLRTLADQLEGRKELLSSDMKKDFVMHRLPPFCVGNGTESMNPGGKLPRLNSIVRLQFKDHIVLTVGPDQNQSDEAQQKVVYIYHSLKNERQTHMMGKEVETEIYGLRFPLSYVDALKQIWCGSPVRVKDLKLGTDEEKENLAVSLWTECLVHVL", "length": 465 }, "evidence": [ { "id": "Q5EA24", "url": "https://omabrowser.org/oma/group/Q5EA24/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8IUF8-1", "protein_name": "Ribosomal oxygenase 2", "gene_name": "RIOX2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPKKAKPTGSGKEEGPAPCKQMKLEAAGGPSALNFDSPSSLFESLISPIKTETFFKEFWEQKPLLIQRDDPALATYYGSLFKLTDLKSLCSRGMYYGRDVNVCRCVNGKKKVLNKDGKAHFLQLRKDFDQKRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGSQGLPPHYDDVEVFILQLEGEKHWRLYHPTVPLAREYSVEAEERIGRPVHEFMLKPGDLLYFPRGTIHQADTPAGLAHSTHVTISTYQNNSWGDFLLDTISGLVFDTAKEDVELRTGIPRQLLLQVESTTVATRRLSGFLRTLADRLEGTKELLSSDMKKDFIMHRLPPYSAGDGAELSTPGGKLPRLDSVVRLQFKDHIVLTVLPDQDQSDEAQEKMVYIYHSLKNSRETHMMGNEEETEFHGLRFPLSHLDALKQIWNSPAISVKDLKLTTDEEKESLVLSLWTECLIQVV", "length": 465 }, "evidence": [ { "id": "Q5EA24", "url": "https://omabrowser.org/oma/group/Q5EA24/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "histone H3K36 demethylase activity", "id": "GO:0051864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051864", "evidence": [ { "database": "UniProtKB", "id": "Q5EA24", "url": "https://www.uniprot.org/uniprotkb/Q5EA24" } ], "pmid": "" }, { "name": "histone H3K4 demethylase activity", "id": "GO:0032453", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032453", "evidence": [ { "database": "UniProtKB", "id": "Q5EA24", "url": "https://www.uniprot.org/uniprotkb/Q5EA24" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q5EA24", "url": "https://www.uniprot.org/uniprotkb/Q5EA24" } ], "pmid": "" }, { "name": "peptidyl-histidine dioxygenase activity", "id": "GO:0036139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036139", "evidence": [ { "database": "UniProtKB", "id": "Q5EA24", "url": "https://www.uniprot.org/uniprotkb/Q5EA24" } ], "pmid": "" }, { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "Q5EA24", "url": "https://www.uniprot.org/uniprotkb/Q5EA24" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q5EA24", "url": "https://www.uniprot.org/uniprotkb/Q5EA24" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q5EA24", "url": "https://www.uniprot.org/uniprotkb/Q5EA24" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q5EA24", "url": "https://www.uniprot.org/uniprotkb/Q5EA24" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q5EA24", "url": "https://www.uniprot.org/uniprotkb/Q5EA24" } ], "pmid": "" }, { "name": "ribosome biogenesis", "id": "GO:0042254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042254", "evidence": [ { "database": "UniProtKB", "id": "Q5EA24", "url": "https://www.uniprot.org/uniprotkb/Q5EA24" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 407, "end_pos": 409, "annotation": "n_glycosylation_sequon" }, { "start_pos": 429, "end_pos": 431, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "54024", "name": "", "equation": "L-histidyl-[ribosomal protein uL15] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + succinate + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5EA24-1" ], "evidence": [ { "id": "54024", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/54024" } ] }, { "id": "54256", "name": "", "equation": "L-histidyl-[protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl-[protein] + succinate + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A5PK74-1", "Q5EA24-1" ], "evidence": [ { "id": "54256", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/54256" } ] }, { "id": "R-BTA-4724279", "name": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BA41-1", "E1BPL5-1", "Q5EA24-1", "A0AAA9SM03-1", "E1BB12-1" ], "evidence": [ { "id": "R-BTA-4724279", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4724279" } ] }, { "id": "R-BTA-5661120", "name": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BA41-1", "E1BPL5-1", "Q5EA24-1", "A0AAA9SM03-1", "E1BB12-1" ], "evidence": [ { "id": "R-BTA-5661120", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5661120" } ] }, { "id": "R-BTA-9630967", "name": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-9630984" ], "output_participant_list": [ "R-BTA-9630970" ], "enzyme_list": [ "Q5EA24-1" ], "evidence": [ { "id": "R-BTA-9630967", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9630967" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-9630970", "participant_name": "RPL27A [nucleoplasm]", "crossref": [ { "id": "Q56K03", "database": "UniProt", "url": "" }, { "id": "NP_001019642.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-BTA-9630984", "participant_name": "RPL27A [nucleoplasm]", "crossref": [ { "id": "Q56K03", "database": "UniProt", "url": "" }, { "id": "NP_001019642.1", "database": "RefSeq", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SM03", "gene_name": "KDM4C", "activity": [ { "ec_number": "1.14.11.66", "activity": "N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone 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"https://www.uniprot.org/uniprotkb/A5PK74" } ] }, { "ec_number": "1.14.11.-", "activity": "", "evidence": [ { "id": "A5PK74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PK74" } ] } ] }, { "uniprot_ac": "E1BA41", "gene_name": "KDM4B", "activity": [ { "ec_number": "1.14.11.66", "activity": "N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2.", "evidence": [ { "id": "E1BA41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA41" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "E1BA41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA41" } ] } ] }, { "uniprot_ac": "E1BB12", "gene_name": "KDM4D", "activity": [ { "ec_number": "1.14.11.66", "activity": "N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2.", "evidence": [ { "id": "E1BB12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB12" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "E1BB12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB12" } ] } ] }, { "uniprot_ac": "E1BPL5", "gene_name": "KDM4A", "activity": [ { "ec_number": "1.14.11.69", "activity": "N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2.", "evidence": [ { "id": "E1BPL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPL5" } ] }, { "ec_number": "1.14.11.66", "activity": "N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2.", "evidence": [ { "id": "E1BPL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPL5" } ] }, { "ec_number": "1.14.11.69", "activity": "", "evidence": [ { "id": "E1BPL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPL5" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "E1BPL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPL5" } ] } ] }, { "uniprot_ac": "Q5EA24", "gene_name": "RIOX2", "activity": [ { "ec_number": "1.14.11.-", "activity": "", "evidence": [ { "id": "Q5EA24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA24" } ] }, { "ec_number": "1.14.11.79", "activity": "L-histidyl-[protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl-[protein] + succinate + CO2.", "evidence": [ { "id": "Q5EA24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA24" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA24-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 462, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA24-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA24" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5EA24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA24" }, { "id": "PRU00538", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00538" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "JmjC", "eco_id": "ECO_0000255", "start_pos": 139, "end_pos": 271, "start_aa": "Gln", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "Q5EA24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA24#function" }, { "id": "Q5EA24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA24" }, { "id": "PRU00538", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00538" } ], "binding_site_uniprot": 179, "amino_acid": "His", "chebi_lig_id": "CHEBI_24875", "ligand": "Fe 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"MLLLPLSVLLLLTQPWRSLGAEMKIYSQKTLANGCTLVVCRPPEGGLPGRDGQDGREGPQGEKGDPGSPGPAGRAGRPGPAGPIGPKGDNGSAGEPGPKGDTGPPGPPGMPGPAGREGPSGKQGSMGPPGTPGPKGDTGPKGGMGAPGMQGSPGPAGLKGERGAPGELGAPGSAGVAGPAGAIGPQGPSGARGPPGLKGDRGDPGERGAKGESGLADVNALKQRVTILEGQLQRLQNAFSRYKKAVLFPDGQAVGKKIFKTAGAVKSYSDAQQLCREAKGQLASPRSAAENEAVAQLVRAKNNDAFLSMNDISTEGKFTYPTGESLVYSNWASGEPNNNNAGQPENCVQIYREGKWNDVPCSEPLLVICEF", "length": 371, "header": "sp|Q8MHZ9-1|CL46_BOVIN Isoform 1 of Collectin-46 OS=Bos taurus OX=9913 GN=CL46 PE=2 SV=1 CANONICAL=Q8MHZ9-1" }, "isoforms": [ { "isoform_ac": "A0A452DJR7-1", "url": "https://www.uniprot.org/uniprotkb/Q8MHZ9/entry#A0A452DJR7-1", "sequence": { "sequence": 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"sequence": "MLLLPLSVLLLLTQPWRSLGAEMKIYSQKTLANGCTLVVCRPPEGGLPGRDGQDGREGPQGEKGDPGSPGPAGRAGRPGPAGPIGPKGDNGSAGEPGPKGDTGPPGPPGMPGPAGREGPSGKQGSMGPPGTPGPKGDTGPKGGMGAPGMQGSPGPAGLKGERGAPGELGAPGSAGVAGPAGAIGPQGPSGARGPPGLKGDRGDPGERGAKGESGLADVNALKQRVTILEGQLQRLQNAFSRYKKAVLFPDGQAVGKKIFKTAGAVKSYSDAQQLCREAKGQLASPRSAAENEAVAQLVRAKNNDAFLSMNDISTEGKFTYPTGESLVYSNWASGEPNNNNAGQPENCVQIYREGKWNDVPCSEPLLVICEF", "length": 371, "header": "sp|Q8MHZ9-1|CL46_BOVIN Isoform 1 of Collectin-46 OS=Bos taurus OX=9913 GN=CL46 PE=2 SV=1 CANONICAL=Q8MHZ9-1" }, "locus": { "chromosome": "28", "start_pos": 35476734, "end_pos": 35467489, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018649.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018649.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018649.6", "url": "https://www.ensembl.org/id/ENSBTAP00000018649.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": 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"https://www.genome.jp/dbget-bin/www_bget?bta:415114", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q8MHZ9", "url": "https://www.uniprot.org/uniprotkb/Q8MHZ9" } ], "pmid": "" }, { "name": "multivesicular body", "id": "GO:0005771", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005771", "evidence": [ { "database": "UniProtKB", "id": "Q8MHZ9", "url": "https://www.uniprot.org/uniprotkb/Q8MHZ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "surfactant homeostasis", "id": "GO:0043129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043129", "evidence": [ { "database": "UniProtKB", "id": "Q8MHZ9", "url": "https://www.uniprot.org/uniprotkb/Q8MHZ9" } ], "pmid": "" }, { "name": "positive regulation of 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"OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZC33", "url": "https://www.orthodb.org/?gene=Q3ZC33", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43762", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43762", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43762:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43762:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01565", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01565", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04030", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04030", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029215", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "32363", "url": "https://www.rhea-db.org/rhea/32363", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S1F0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1F0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1F0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1F0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZD32", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZD32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZD32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZD32-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P7M4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P7M4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P7M4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P7M4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC33", "url": "https://www.uniprot.org/uniprotkb/Q3ZC33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC33-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC33-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVHGYKGVKFQNWARTYGCCPEMYFQPTSVEEVREVLALARQQNKRVKVVGGGHSPSDIACTDGFMIHMGKMNRVLKVDTEKKQVTVEAGILLADLHPQLDKHGLALSNLGAVSDVTAGGVIGSGTHNTGIKHGILATQVVALTLLTANGTILECSESSNAEVFQAARVHLGCLGVILTVTLQCVPQFHLQETTFPSTLKEVLDNLDSHLKKSEYFRFLWFPHSENVSVIYQDHTNKPPSSSANWFWDYAIGFYLLEFLLWISTFLPGLVGWINRFFFWLLFNGKKENCNLSHKIFTYECRFKQHVQDWAIPREKTKEALLELKAMLEANPKVVAHYPVEVRFTRGDDILLSPCFQRDSCYMNIIMYRPYGKDVPRLDYWLAYETIMKKVGGRPHWAKAHNCTRKDFEKMYPAFQRFCAIREKLDPTGMFLNAYLEKVFY", "length": 440, "header": "sp|Q3ZC33-1|GGLO_BOVIN Isoform 1 of L-gulonolactone oxidase OS=Bos taurus OX=9913 GN=GULO PE=2 SV=3 CANONICAL=Q3ZC33-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S1F0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC33/entry#A0AAA9S1F0-1", "sequence": { "sequence": "MESPRRAPSCRRRLVHGYKGVKFQNWARTYGCCPEMYFQPTSVEEVREVLALARQQNKRVKVVGGGHSPSDIACTDGFMIHMGKMNRVLKVDTEKKQVTVEAGILLADLHPQLDKHGLALSNLGAVSDVTAGGVIGSGTHNTGIKHGILATQVVALTLLTANGTILECSESSNAEVFQAARVHLGCLGVILTVTLQCVPQFHLQETTFPSTLKEVLDNLDSHLKKSEYFRFLWFPHSENVSVIYQDHTNKPPSSSANWFWDYAIGFYLLEFLLWISTFLPGLVGWINRFFFWLLFNGKKENCNLSHKIFTYECRFKQHVQDWAIPREKTKEALLELKAMLEANPKVVAHYPVEVRFTRGDDILLSPCFQRDSCYMNIIMYRPYGKDVPRLDYWLAYETIMKKVGGRPHWAKAHNCTRKDFEKMYPAFQRFCAIREKLDPTGMFLNAYLEKVFY", "length": 453, "header": "tr|A0AAA9S1F0-1|GGLO_BOVIN Computationally mapped isoform of L-gulonolactone oxidase OS=Bos taurus OX=9913 GN=GULO PE=2 SV=1 CANONICAL=Q3ZC33-1" }, "locus": { "chromosome": "8", "start_pos": 74693233, "end_pos": 74669925, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109972.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109972.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077136.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077136.1" } ] } }, { "isoform_ac": "A0AAF6ZD32-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC33/entry#A0AAF6ZD32-1", "sequence": { "sequence": "MAVARRCTFSPRPWRRSESSFLEWPAQRLPARQHLGDWGCNTWVSRLPRRERPGLRLMQMLPPQVLALARQQNKRVKVVGGGHSPSDIACTDGFMIHMGKMNRVLKVDTEKKQVTVEAGILLADLHPQLDKHGLALSNLGAVSDVTAGGVIGSGTHNTGIKHGILATQVVALTLLTANGTILECSESSNAEVFQAARVHLGCLGVILTVTLQCVPQFHLQETTFPSTLKEVLDNLDSHLKKSEYFRFLWFPHSENVSVIYQDHTNKPPSSSANWFWDYAIGFYLLEFLLWISTFLPGLVGWINRFFFWLLFNGKKENCNLSHKIFTYECRFKQHVQDWAIPREKTKEALLELKAMLEANPKVVAHYPVEVRFTRGDDILLSPCFQRDSCYMNIIMYRPYGKDVPRLDYWLAYETIMKKVGGRPHWAKAHNCTRKDFEKMYPAFQRFCAIREKLDPTGMFLNAYLEKVFY", "length": 469, "header": "tr|A0AAF6ZD32-1|GGLO_BOVIN Computationally mapped isoform of L-gulonolactone oxidase OS=Bos taurus OX=9913 GN=GULO PE=2 SV=1 CANONICAL=Q3ZC33-1" }, "locus": { "chromosome": "8", "start_pos": 74693233, "end_pos": 74669474, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038177.6", "url": "https://www.ensembl.org/id/ENSBTAT00000038177.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037993.5", "url": "https://www.ensembl.org/id/ENSBTAP00000037993.5" } ] } }, { "isoform_ac": "A0ABI0P7M4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC33/entry#A0ABI0P7M4-1", "sequence": { "sequence": "VHGYKGVKFQNWARTYGCCPEMYFQPTSVEEVREVLALARQQNKRVKVVGGGHSPSDIACTDGFMIHMGKMNRVLKVDTEKKQVTVEAGILLADLHPQLDKHGLALSNLGAVSDVTAGGVIGSGTHNTGIKHGILATQVVALTLLTANGTILECSESSNAEVFQAARVHLGCLGVILTVTLQCVPQFHLQETTFPSTLKEVLDNLDSHLKKSEYFRFLWFPHSENVSVIYQDHTNKPPSSSANWFWDYAIGFYLLEFLLWISTFLPGLVGWINRFFFWLLFNGKKENCNLSHKIFTYECRFKQHVQDWAIPREKTKEALLELKAMLEANPKVVAHYPVEVRFTRGDDILLSPCFQRDSCYMNIIMYRPYGKDVPRLDYWLAYETIMKKVGGRPHWAKAHNCTRKDFEKMYPAFQRFCAIREKLDPTGMFLNAYLEKVFY", "length": 439, "header": "tr|A0ABI0P7M4-1|A0ABI0P7M4_BOVIN Computationally mapped isoform of L-gulonolactone oxidase OS=Bos taurus OX=9913 GN=GULO PE=3 SV=1 CANONICAL=Q3ZC33-1" }, "locus": { "chromosome": "8", "start_pos": 74693233, "end_pos": 74670454, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152607.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152607.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107228.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107228.1" } ] } }, { "isoform_ac": "Q3ZC33-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC33/entry#Q3ZC33-1", "sequence": { "sequence": "MVHGYKGVKFQNWARTYGCCPEMYFQPTSVEEVREVLALARQQNKRVKVVGGGHSPSDIACTDGFMIHMGKMNRVLKVDTEKKQVTVEAGILLADLHPQLDKHGLALSNLGAVSDVTAGGVIGSGTHNTGIKHGILATQVVALTLLTANGTILECSESSNAEVFQAARVHLGCLGVILTVTLQCVPQFHLQETTFPSTLKEVLDNLDSHLKKSEYFRFLWFPHSENVSVIYQDHTNKPPSSSANWFWDYAIGFYLLEFLLWISTFLPGLVGWINRFFFWLLFNGKKENCNLSHKIFTYECRFKQHVQDWAIPREKTKEALLELKAMLEANPKVVAHYPVEVRFTRGDDILLSPCFQRDSCYMNIIMYRPYGKDVPRLDYWLAYETIMKKVGGRPHWAKAHNCTRKDFEKMYPAFQRFCAIREKLDPTGMFLNAYLEKVFY", "length": 440, "header": "sp|Q3ZC33-1|GGLO_BOVIN Isoform 1 of L-gulonolactone oxidase OS=Bos taurus OX=9913 GN=GULO PE=2 SV=3 CANONICAL=Q3ZC33-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:286812", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:286812", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P10867-1", "protein_name": "L-gulonolactone oxidase", "gene_name": "Gulo", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVHGYKGVQFQNWAKTYGCSPEVYYQPTSVEEVREVLALAREQKKKVKVVGGGHSPSDIACTDGFMIHMGKMNRVLQVDKEKKQITVEAGILLADLHPQLDEHGLAMSNLGAVSDVTVAGVIGSGTHNTGIKHGILATQVVALTLMTADGEVLECSESRNADVFQAARVHLGCLGIILTVTLQCVPQFHLQETSFPSTLKEVLDNLDSHLKRSEYFRFLWFPHTENVSIIYQDHTNKAPSSASNWFWDYAIGFYLLEFLLWTSTYLPCLVGWINRFFFWMLFNCKKESSNLSHKIFTYECRFKQHVQDWAIPREKTKEALLELKAMLEAHPKVVAHYPVEVRFTRGDDILLSPCFQRDSCYMNIIMYRPYGKDVPRLDYWLAYETIMKKFGGRPHWAKAHNCTQKDFEEMYPTFHKFCDIREKLDPTGMFLNSYLEKVFY", "length": 440 }, "evidence": [ { "id": "Q3ZC33", "url": "https://omabrowser.org/oma/group/Q3ZC33/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P54783-1", "protein_name": "D-arabinono-1,4-lactone oxidase", "gene_name": "ALO1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSTIPFRKNYVFKNWAGIYSAKPERYFQPSSIDEVVELVKSARLAEKSLVTVGSGHSPSNMCVTDEWLVNLDRLDKVQKFVEYPELHYADVTVDAGMRLYQLNEFLGAKGYSIQNLGSISEQSVAGIISTGSHGSSPYHGLISSQYVNLTIVNGKGELKFLDAENDPEVFKAALLSVGKIGIIVSATIRVVPGFNIKSTQEVITFENLLKQWDTLWTSSEFIRVWWYPYTRKCVLWRGNKTTDAQNGPAKSWWGTKLGRFFYETLLWISTKIYAPLTPFVEKFVFNRQYGKLEKSSTGDVNVTDSISGFNMDCLFSQFVDEWGCPMDNGLEVLRSLDHSIAQAAINKEFYVHVPMEVRCSNTTLPSEPLDTSKRTNTSPGPVYGNVCRPFLDNTPSHCRFAPLENVTNSQLTLYINATIYRPFGCNTPIHKWFTLFENTMMVAGGKPHWAKNFLGSTTLAAGPVKKDTDYDDFEMRGMALKVEEWYGEDLKKFRKIRKEQDPDNVFLANKQWAIINGIIDPSELSD", "length": 526 }, "evidence": [ { "id": "Q3ZC33", "url": "https://omabrowser.org/oma/group/Q3ZC33/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P58710-1", "protein_name": "L-gulonolactone oxidase", "gene_name": "Gulo", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVHGYKGVQFQNWAKTYGCSPEMYYQPTSVGEVREVLALARQQNKKVKVVGGGHSPSDIACTDGFMIHMGKMNRVLQVDKEKKQVTVEAGILLTDLHPQLDKHGLALSNLGAVSDVTVGGVIGSGTHNTGIKHGILATQVVALTLMKADGTVLECSESSNADVFQAARVHLGCLGVILTVTLQCVPQFHLLETSFPSTLKEVLDNLDSHLKKSEYFRFLWFPHSENVSIIYQDHTNKEPSSASNWFWDYAIGFYLLEFLLWTSTYLPRLVGWINRFFFWLLFNCKKESSNLSHKIFSYECRFKQHVQDWAIPREKTKEALLELKAMLEAHPKVVAHYPVEVRFTRGDDILLSPCFQRDSCYMNIIMYRPYGKDVPRLDYWLAYETIMKKFGGRPHWAKAHNCTRKDFEKMYPAFHKFCDIREKLDPTGMFLNSYLEKVFY", "length": 440 }, "evidence": [ { "id": "Q3ZC33", "url": "https://omabrowser.org/oma/group/Q3ZC33/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "flavin adenine dinucleotide binding", "id": "GO:0050660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050660", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC33", "url": "https://www.uniprot.org/uniprotkb/Q3ZC33" } ], "pmid": "" }, { "name": "FAD binding", "id": "GO:0071949", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071949", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC33", "url": "https://www.uniprot.org/uniprotkb/Q3ZC33" } ], "pmid": "" }, { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC33", "url": "https://www.uniprot.org/uniprotkb/Q3ZC33" } ], "pmid": "" }, { "name": "D-arabinono-1,4-lactone oxidase activity", "id": "GO:0003885", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003885", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC33", "url": "https://www.uniprot.org/uniprotkb/Q3ZC33" } ], "pmid": "" }, { "name": "L-gulonolactone oxidase activity", "id": "GO:0050105", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050105", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC33", "url": "https://www.uniprot.org/uniprotkb/Q3ZC33" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC33", "url": "https://www.uniprot.org/uniprotkb/Q3ZC33" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "L-ascorbic acid biosynthetic process", "id": "GO:0019853", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019853", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC33", "url": "https://www.uniprot.org/uniprotkb/Q3ZC33" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 149, "end_pos": 151, "annotation": "n_glycosylation_sequon" }, { "start_pos": 226, "end_pos": 228, "annotation": "n_glycosylation_sequon" }, { "start_pos": 290, "end_pos": 292, "annotation": "n_glycosylation_sequon" }, { "start_pos": 401, "end_pos": 403, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "32363", "name": "", "equation": "L-gulono-1,4-lactone + O2 = L-ascorbate + H2O2 + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZC33-1" ], "evidence": [ { "id": "32363", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/32363" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q3ZC33", "gene_name": "GULO", "activity": [ { "ec_number": "1.1.3.8", "activity": "L-gulono-1,4-lactone + O2 = L-ascorbate + H2O2 + H(+).", "evidence": [ { "id": "Q3ZC33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC33" } ] }, { "ec_number": "1.1.3.8", "activity": "", "evidence": [ { "id": "Q3ZC33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC33" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZC33-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 440, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZC33-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZC33" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZC33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC33" }, { "id": "PRU00718", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00718" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAD-binding PCMH-type", "eco_id": "ECO_0000255", "start_pos": 17, "end_pos": 187, "start_aa": "Tyr", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.1.3.8", "ec_name": "L-gulono-1,4-lactone + O2 = L-ascorbate + H2O2 + H(+).", "evidence": [ { "id": "1.1.3.8", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.8" }, { "id": "1.1.3.8", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.1.3.8" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 149, "end_pos": 151 }, { "start_pos": 226, "end_pos": 228 }, { "start_pos": 290, "end_pos": 292 }, { "start_pos": 401, "end_pos": 403 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBK3-1", "uniprot_ac": "Q3ZBK3", "uniprot_id": "SPC25_BOVIN", "mass": { "chemical_mass": 26608.0, "monoisotopic_mass": 26608.0 }, "refseq": { "ac": "NP_001029402", "name": "kinetochore protein Spc25", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029402" }, "gene_names": [ { "name": "SPC25", "type": "recommended", "evidence": [ { "id": "Q3ZBK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3" } ] }, { "name": "SPBC25", "type": "synonym", "evidence": [ { "id": "NP_001029402", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029402" }, { "id": "Q3ZBK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3" } ] }, { "name": "SPC25", "type": "synonym", "evidence": [ { "id": "NP_001029402", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029402" } ] } ], "protein_names": [ { "name": "Kinetochore protein Spc25", "type": "recommended", "evidence": [ { "id": "Q3ZBK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3/entry#names_and_taxonomy" } ] }, { "name": "SPC25, NDC80 kinetochore complex component, homolog", "type": "synonym", "evidence": [ { "id": "NP_001029402", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029402" } ] }, { "name": "kinetochore protein Spc25", "type": "synonym", "evidence": [ { "id": "NP_001029402", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029402" } ] }, { "name": "spindle pole body component 25 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029402", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029402" } ] } ], "function": [ { "annotation": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZTD5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZTD5#function" }, { "database": "UniProtKB", "id": "ARBA00045419", "url": "https://www.uniprot.org/uniprotkb/ARBA00045419#function" }, { "database": "UniProtKB", "id": "Q3ZBK3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3#function" }, { "database": "UniProtKB", "id": "Q9HBM1", "url": "https://www.uniprot.org/uniprotkb/Q9HBM1#function" }, { "database": "UniProtKB", "id": "A0AAA9S6C4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C4#function" }, { "database": "UniProtKB", "id": "A0ABI0NUZ5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUZ5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPC25", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3", "locus": { "chromosome": "2", "start_pos": 27287378, "end_pos": 27248564, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010048", "url": "https://www.ensembl.org/id/ENSBTAG00000010048" } ] } } ], "crossref": [ { "id": "Q3ZBK3", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBK3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010048", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010048", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23784", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23784", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505011", "url": "https://www.ncbi.nlm.nih.gov/gene/505011", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013255", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013255", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505011", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505011", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KNINEFW", "url": "https://omabrowser.org/oma/group/KNINEFW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBK3", "url": "https://www.orthodb.org/?gene=Q3ZBK3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14281", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14281", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14281:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14281:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08234", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08234", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-141430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-141444", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2500257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9648025", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029402", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6C4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6C4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6C4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZTD5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZTD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZTD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZTD5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NUZ5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NUZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBK3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBK3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVEDELALFDKSINEFWNKFKSTVSDTSCQMVGLRETYKDSIKAFAEKLSVKLKEEERMVEMFLEYQNQICRQNKLIQEKKENLLKLIAEVKDKKQEVEALTANIQDLKEEYARKKETISTANKANEERLKRLQKSADLYKDRLGLEIRKIYGDKLQFIFTDIDPKHPDRPFMFSLCLNEARDYEVSDCAPRLECLAEFQEKVRQTNNFSAFLANVRKAFTALVYN", "length": 226, "header": "sp|Q3ZBK3-1|SPC25_BOVIN Isoform 1 of Kinetochore protein Spc25 OS=Bos taurus OX=9913 GN=SPC25 PE=2 SV=1 CANONICAL=Q3ZBK3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6C4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3/entry#A0AAA9S6C4-1", "sequence": { "sequence": "MVEDELALFDKSINEFWNKFKSTVSDTSCQMVGLRETYKDSIKAFAEKLSVKLKEEERMVEMFLEYQNQICRQNKLIQEKKENLLKLIAEVKDKKQEVEALTANIQDLKEEYARKKETISTANKANEERLKRLQKSADLYKDRLGLEIRKIYGDKLQFIFTDIDPKHPDRPFMFSLCLNEARDYEVSDCAPRLECLAEFQEKVEK", "length": 205, "header": "tr|A0AAA9S6C4-1|SPC25_BOVIN Computationally mapped isoform of Kinetochore protein Spc25 OS=Bos taurus OX=9913 GN=SPC25 PE=2 SV=1 CANONICAL=Q3ZBK3-1" }, "locus": { "chromosome": "2", "start_pos": 27262368, "end_pos": 27249720, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098346.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098346.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080752.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080752.1" } ] } }, { "isoform_ac": "A0AAF6ZTD5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3/entry#A0AAF6ZTD5-1", "sequence": { "sequence": "MVEDELALFDKSINEFWNKFKSTVSDTSCQMVGLRETYKDSIKAFAEKLSVKLKEEERMVEMFLEYQNQICRQNKLIQEKKENLLKLIAEVKDKKQEVEALTANIQDLKEEYARKKETISTANKANEERLKRLQKSADLYKDRLGLEIRKIYGDKLQFIFTDIDPKHPDRPFMFSLCLNEARDYEVSDCAPRLECLAEFQEKLQDALKG", "length": 209, "header": "tr|A0AAF6ZTD5-1|SPC25_BOVIN Computationally mapped isoform of Kinetochore protein Spc25 OS=Bos taurus OX=9913 GN=SPC25 PE=2 SV=1 CANONICAL=Q3ZBK3-1" }, "locus": { "chromosome": "2", "start_pos": 27287361, "end_pos": 27249720, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070517.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070517.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057478.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057478.2" } ] } }, { "isoform_ac": "A0ABI0NUZ5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3/entry#A0ABI0NUZ5-1", "sequence": { "sequence": "MVEDELALFDKSINEFWNKFKSTVSDTSCQMVGLRETYKDSIKAFAEICRQNKLIQEKKENLLKLIAEVKDKKQEVEALTANIQDLKEEYARKKETISTANKANEERLKRLQKSADLYKDRLGLEIRKIYGDKLQFIFTDIDPKHPDRPFMFSLCLNEARDYEVSDCAPRLECLAEFQEKVRQTNNFSAFLANVRKAFTALVYN", "length": 204, "header": "tr|A0ABI0NUZ5-1|A0ABI0NUZ5_BOVIN Computationally mapped isoform of Kinetochore protein SPC25 OS=Bos taurus OX=9913 GN=SPC25 PE=3 SV=1 CANONICAL=Q3ZBK3-1" }, "locus": { "chromosome": "2", "start_pos": 27260747, "end_pos": 27249720, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000144681.1", "url": "https://www.ensembl.org/id/ENSBTAT00000144681.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107611.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107611.1" } ] } }, { "isoform_ac": "Q3ZBK3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3/entry#Q3ZBK3-1", "sequence": { "sequence": "MVEDELALFDKSINEFWNKFKSTVSDTSCQMVGLRETYKDSIKAFAEKLSVKLKEEERMVEMFLEYQNQICRQNKLIQEKKENLLKLIAEVKDKKQEVEALTANIQDLKEEYARKKETISTANKANEERLKRLQKSADLYKDRLGLEIRKIYGDKLQFIFTDIDPKHPDRPFMFSLCLNEARDYEVSDCAPRLECLAEFQEKVRQTNNFSAFLANVRKAFTALVYN", "length": 226, "header": "sp|Q3ZBK3-1|SPC25_BOVIN Isoform 1 of Kinetochore protein Spc25 OS=Bos taurus OX=9913 GN=SPC25 PE=2 SV=1 CANONICAL=Q3ZBK3-1" }, "locus": { "chromosome": "2", "start_pos": 27260747, "end_pos": 27249720, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147094.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147094.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104056.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104056.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 12, "end_pos": 12, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3" } ], "site_lbl": "Ser12" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505011", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505011", "resource": "KEGG Pathway" }, { "id": "R-BTA-141430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "resource": "Reactome", "description": "Inactivation of APC/C via direct inhibition of the APC/C complex" }, { "id": "R-BTA-141444", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "resource": "Reactome", "description": "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2500257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "resource": "Reactome", "description": "Resolution of Sister Chromatid Cohesion" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" }, { "id": "R-BTA-9648025", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "resource": "Reactome", "description": "EML4 and NUDC in mitotic spindle formation" } ], "orthologs": [ { "uniprot_canonical_ac": "G3GU82-1", "protein_name": "Kinetochore protein SPC25", "gene_name": "Spc25", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MFEDELALFDKSINEFGEKFRNSLIGNPSQVLGVRDAFRDSIRALSEKLSLKLKEEERMVEMFLDYQNQLCKQNKLIQEKKDNLLKMVDEVKGKKQELEVLIANIKDLKEEYSRKKETISTANKANEDKLKRLQKSADMYRDCLGLEIRKVPGDKLQFIFTSIDPKNPESPYMFSLSLNEARDYEVSDCSPHLECLAEFQEKVRKTNNFSAFLANVRKAFIATVYN", "length": 226 }, "evidence": [ { "id": "Q3ZBK3", "url": "https://omabrowser.org/oma/group/Q3ZBK3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q3UA16-1", "protein_name": "Kinetochore protein Spc25", "gene_name": "Spc25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGEDELALLNQSINEFGDKFRNRLDDNHSQVLGLRDAFKDSMKAFSEKMSLKLKEEERMTEMILEYKNQLCKQNKLIQEKKENVLKMIAEVKGKEQESEELTAKIQELKEEYARKRETISTANKANEERLKGLQKSADLYRDYLGLEIRKIHGNKLQFIFTSIDPKNPESPYMFSMSINEAKEYEVYDSSPHLECLAEFQEKVRKTNNFSAFLANIRKAFIAKVHN", "length": 226 }, "evidence": [ { "id": "Q3ZBK3", "url": "https://omabrowser.org/oma/group/Q3ZBK3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5M856-1", "protein_name": "Kinetochore protein Spc25", "gene_name": "Spc25", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGEDELAAFEKSINEFGDKFRYRLSDNRSQVLGLKDAFKDSIRALSEKLSLKLKEEERMAEMILEYKNQLCKQNKLIQEKKDNVLKMIAEVKGKGQEVEVLTANIQDLKEEYARKKETISTANKANEERLKRLQKSADLYRDRLGLEIRKIPGDKLQFIFTSIDPKNPESPFMFSLSINEAKEYEVSDCSPHLECLAEFQEKVRKTNNFSAFLANVRKAFIAKVHN", "length": 226 }, "evidence": [ { "id": "Q3ZBK3", "url": "https://omabrowser.org/oma/group/Q3ZBK3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9HBM1-1", "protein_name": "Kinetochore protein Spc25", "gene_name": "SPC25", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVEDELALFDKSINEFWNKFKSTDTSCQMAGLRDTYKDSIKAFAEKLSVKLKEEERMVEMFLEYQNQISRQNKLIQEKKDNLLKLIAEVKGKKQELEVLTANIQDLKEEYSRKKETISTANKANAERLKRLQKSADLYKDRLGLEIRKIYGEKLQFIFTNIDPKNPESPFMFSLHLNEARDYEVSDSAPHLEGLAEFQENVRKTNNFSAFLANVRKAFTATVYN", "length": 224 }, "evidence": [ { "id": "Q3ZBK3", "url": "https://omabrowser.org/oma/group/Q3ZBK3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Ndc80 complex", "id": "GO:0031262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031262", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3" } ], "pmid": "" }, { "name": "attachment of spindle microtubules to kinetochore", "id": "GO:0008608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008608", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3" } ], "pmid": "" }, { "name": "mitotic spindle organization", "id": "GO:0007052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007052", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBK3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 226, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBK3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBK3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 12 ], "sequon_annotation_sites": [ { "start_pos": 208, "end_pos": 210 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q5E9X1-1", "uniprot_ac": "Q5E9X1", "uniprot_id": "NFYC_BOVIN", "mass": { "chemical_mass": 37134.0, "monoisotopic_mass": 37134.0 }, "refseq": { "ac": "NP_001029770", "name": "nuclear transcription factor Y subunit gamma", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029770" }, "gene_names": [ { "name": "NFYC", "type": "recommended", "evidence": [ { "id": "Q5E9X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1" } ] }, { "name": "NFYC", "type": "synonym", "evidence": [ { "id": "NP_001029770", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029770" } ] } ], "protein_names": [ { "name": "Nuclear transcription factor Y subunit gamma", "type": "recommended", "evidence": [ { "id": "Q5E9X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1/entry#names_and_taxonomy" } ] }, { "name": "CAAT box DNA-binding protein subunit C", "type": "synonym", "evidence": [ { "id": "NP_001029770", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029770" }, { "id": "Q5E9X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1/entry#names_and_taxonomy" } ] }, { "name": "NF-YC", "type": "synonym", "evidence": [ { "id": "NP_001029770", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029770" }, { "id": "Q5E9X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1/entry#names_and_taxonomy" } ] }, { "name": "Nuclear transcription factor Y subunit C", "type": "synonym", "evidence": [ { "id": "Q5E9X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1/entry#names_and_taxonomy" } ] }, { "name": "nuclear transcription factor Y subunit C", "type": "synonym", "evidence": [ { "id": "NP_001029770", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029770" } ] }, { "name": "nuclear transcription factor Y subunit gamma", "type": "synonym", "evidence": [ { "id": "NP_001029770", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029770" } ] }, { "name": "nuclear transcription factor Y, gamma", "type": "synonym", "evidence": [ { "id": "NP_001029770", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029770" } ] } ], "function": [ { "annotation": "Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZUW3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZUW3#function" }, { "database": "UniProtKB", "id": "ARBA00025263", "url": "https://www.uniprot.org/uniprotkb/ARBA00025263#function" }, { "database": "UniProtKB", "id": "A0AAF7AE01", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AE01#function" }, { "database": "UniProtKB", "id": "Q5E9X1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9X1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NFYC", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1", "locus": { "chromosome": "3", "start_pos": 105445533, "end_pos": 105510073, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021943", "url": "https://www.ensembl.org/id/ENSBTAG00000021943" } ] } } ], "crossref": [ { "id": "Q5E9X1", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9X1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021943", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021943", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22908", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22908", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534003", "url": "https://www.ncbi.nlm.nih.gov/gene/534003", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007125", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007125", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050568", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050568", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534003", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534003", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VCCAQPP", "url": "https://omabrowser.org/oma/group/VCCAQPP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A140T8B0", "url": "https://www.orthodb.org/?gene=A0A140T8B0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5E9X1", "url": "https://www.orthodb.org/?gene=Q5E9X1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10252", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10252", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10252:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10252:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00125", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00125", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029770", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A140T8B0", "url": "https://www.uniprot.org/uniprotkb/A0A140T8B0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T8B0-1", "url": "https://www.uniprot.org/uniprotkb/A0A140T8B0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZUW3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZUW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZUW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZUW3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AE01", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AE01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AE01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AE01-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9X1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9X1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTEGGFGGAGSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRDELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIIIAQPQQGQTTPVTMQVGEGQQVQIVQAQPQGQAQQAQSGTGQTMQVMQQIITNTGEIQQIPVQLNAGQLQYIRLAQPVSGTQVVQGQIQTLATNAQQITQTEVQQGQQQFSQFTDGQQLYQIQQVTMPAGQDLAQPMFIQSANQPSDGQAPQVTGD", "length": 335, "header": "sp|Q5E9X1-1|NFYC_BOVIN Isoform 1 of Nuclear transcription factor Y subunit gamma OS=Bos taurus OX=9913 GN=NFYC PE=2 SV=1 CANONICAL=Q5E9X1-1" }, "isoforms": [ { "isoform_ac": "A0A140T8B0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1/entry#A0A140T8B0-1", "sequence": { "sequence": "MSTEGGFGGAGSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKRNDIAMAITKFDQFDFLIDIVPRDELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIIIAQPQQGQTTPVTMQVGEGQQVQIVQAQPQGQAQQAQSGTGQTMQVMQQIITNTGEIQQIPVQLNAGQLQYIRLAQPVSGTQVVQGQIQTLATNAQQITQTEVQQGQQQFSQFTDGQQLYQIQQVTMPAGQDLAQPMFIQSANQPSDGQAPQVTGD", "length": 297, "header": "tr|A0A140T8B0-1|NFYC_BOVIN Computationally mapped isoform of Nuclear transcription factor Y subunit gamma OS=Bos taurus OX=9913 GN=NFYC PE=2 SV=2 CANONICAL=Q5E9X1-1" }, "locus": { "chromosome": "3", "start_pos": 105474545, "end_pos": 105445837, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029254.5", "url": "https://www.ensembl.org/id/ENSBTAT00000029254.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029254.4", "url": "https://www.ensembl.org/id/ENSBTAP00000029254.4" } ] } }, { "isoform_ac": "A0AAF6ZUW3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1/entry#A0AAF6ZUW3-1", "sequence": { "sequence": "MSTEGGFGGAGSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRDELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIIIAQPQQGQTTPVTMQVGEGQQVQIVQAQPQGQAQQAQSGTGQTMQVMQQIITNTGEIQQIPVQLNAGQLQYIRLAQPVSGTQVVQGQIQTLATNAQQITQTEVQQGQQQFSQFTDGQRNSVQQARGSELTGEAEPREVKATGNATPRTSSLPTTHPCSHRAGASWVCCPQPQQTATSPPPSDAVQWVVVEVSGAPSQLEAHRELHAPLPGVTSLSPLHSSQQLYQIQQVTMPAGQDLAQPMFIQSANQPSDGQAPQVTGD", "length": 439, "header": "tr|A0AAF6ZUW3-1|NFYC_BOVIN Computationally mapped isoform of Nuclear transcription factor Y subunit gamma OS=Bos taurus OX=9913 GN=NFYC PE=2 SV=1 CANONICAL=Q5E9X1-1" }, "locus": { "chromosome": "3", "start_pos": 105474545, "end_pos": 105445837, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074351.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074351.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057952.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057952.2" } ] } }, { "isoform_ac": "A0AAF7AE01-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1/entry#A0AAF7AE01-1", "sequence": { "sequence": "MSAPLRNICQLLLLTPTPPRYPPLAKDFRVQELPLARIKKIMKLDEDVKMISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRDELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIIIAQPQQGQTTPVTMQVGEGQQVQIVQAQPQGQAQQAQSGTGQTMQVMQQIITNTGEIQQIPVQLNAGQLQYIRLAQPVSGTQVVQGQIQTLATNAQQITQTEVQQGQQQFSQFTDGQQLYQIQQVTMPAGQDLAQPMFIQSANQPSDGQAPQVTGD", "length": 325, "header": "tr|A0AAF7AE01-1|NFYC_BOVIN Computationally mapped isoform of Nuclear transcription factor Y subunit gamma OS=Bos taurus OX=9913 GN=NFYC PE=2 SV=1 CANONICAL=Q5E9X1-1" }, "locus": { "chromosome": "3", "start_pos": 105468929, "end_pos": 105445837, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081656.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081656.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067634.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067634.2" } ] } }, { "isoform_ac": "Q5E9X1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1/entry#Q5E9X1-1", "sequence": { "sequence": "MSTEGGFGGAGSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRDELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIIIAQPQQGQTTPVTMQVGEGQQVQIVQAQPQGQAQQAQSGTGQTMQVMQQIITNTGEIQQIPVQLNAGQLQYIRLAQPVSGTQVVQGQIQTLATNAQQITQTEVQQGQQQFSQFTDGQQLYQIQQVTMPAGQDLAQPMFIQSANQPSDGQAPQVTGD", "length": 335, "header": "sp|Q5E9X1-1|NFYC_BOVIN Isoform 1 of Nuclear transcription factor Y subunit gamma OS=Bos taurus OX=9913 GN=NFYC PE=2 SV=1 CANONICAL=Q5E9X1-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 137, "start_aa": "Thr", "end_pos": 137, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr137", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:534003", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534003", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YT94-1", "protein_name": "Nuclear transcription factor Y subunit gamma", "gene_name": "NFYC", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSTDGSFGTGSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRDELKPPKRQEEVRQAVTPAEPVQYYFTLAQQPAAVQVQGQQQGQQTTTSTTTIQPGQIIIAQPQQGQTTPVTMQVGEGQQVQIVQAQPQGQSQQAQSGTGQTMQVMQQIITNTGEIQQIPVQLNAGQLQYIRLAQPVSGTQVVQGQIQTLATNAQQITQTEVQQGQQQFSQFTDGQQLYQIQQVTMPAGQDITQPMFIQSTNQSSDGQATQVTGD", "length": 335 }, "evidence": [ { "id": "Q5E9X1", "url": "https://omabrowser.org/oma/group/Q5E9X1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HCN0-1", "protein_name": "Nuclear transcription factor Y subunit gamma", "gene_name": "Nfyc", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSTEGGFGGTSNSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRDELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIIIAQPQQGQTTPVTMQVGEGQQVQIVQAQPQGQTQQAQSGTGQTMQVMQQIITNTGEIQQIPVQLNAGQLQYIRLAQPVSGTQVVQGQIQTLATNAQQITQTEVQQGQQQFSQFTDGQQLYQIQQVTMPAGQDLAQPMFIQSANQPSDGQTPQVTGD", "length": 335 }, "evidence": [ { "id": "Q5E9X1", "url": "https://omabrowser.org/oma/group/Q5E9X1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P70353-1", "protein_name": "Nuclear transcription factor Y subunit gamma", "gene_name": "Nfyc", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSTEGGFGGTSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRDELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIIIAQPQQGQTTPVTMQVGEGQQVQIVQAQPQGQAQQTQSGTGQTMQVMQQIITNTGEIQQIPVQLNAGQLQYIRLAQPVSGTQVVQGQIQTLATNAQQITQTEVQQGQQQFSQFTDGQQLYQIQQVTMPAGQDLAQPMFIQSANQPSDGQTPQVTGD", "length": 335 }, "evidence": [ { "id": "Q5E9X1", "url": "https://omabrowser.org/oma/group/Q5E9X1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q13952-1", "protein_name": "Nuclear transcription factor Y subunit gamma", "gene_name": "NFYC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSTEGGFGGTSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRDELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIIIAQPQQGQTTPVTMQVGEGQQVQIVQAQPQGQAQQAQSGTGQTMQVMQQIITNTGEIQQIPVQLNAGQLQYIRLAQPVSGTQVVQGQIQTLATNAQQGQRNASQGKPRRCLKETLQITQTEVQQGQQQFSQFTDGQRNSVQQARVSELTGEAEPREVKATGNSTPCTSSLPTTHPPSHRAGASCVCCSQPQQSSTSPPPSDALQWVVVEVSGTPNQLETHRELHAPLPGMTSLSPLHPSQQLYQIQQVTMPAGQDLAQPMFIQSANQPSDGQAPQVTGD", "length": 458 }, "evidence": [ { "id": "Q5E9X1", "url": "https://omabrowser.org/oma/group/Q5E9X1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q62725-1", "protein_name": "Nuclear transcription factor Y subunit gamma", "gene_name": "Nfyc", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSTEGGFGSTSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRDELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIIIAQPQQGQTTPVTMQVGEGQQVQIVQAQPQGQAQQAQSGTGQTMQVMQQIITNTGEIQQIPVQLNAGQLQYIRLAQPVSGTQVVQGQIQTLATNAQQITQTEVQQGQQQFSQFTDGQQLYQIQQVTMPAGQDLAQPMFIQSANQPSDGQTPQVTGD", "length": 335 }, "evidence": [ { "id": "Q5E9X1", "url": "https://omabrowser.org/oma/group/Q5E9X1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1" } ], "pmid": "" }, { "name": "CCAAT-binding factor complex", "id": "GO:0016602", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016602", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1" } ], "pmid": "" }, { "name": "protein-DNA complex", "id": "GO:0032993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032993", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 32, "end_pos": 34, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9X1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 335, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9X1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9X1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 137 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 32, "end_pos": 34 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DK7-1", "uniprot_ac": "Q58DK7", "uniprot_id": "RHIT_BOVIN", "mass": { "chemical_mass": 60459.0, "monoisotopic_mass": 60459.0 }, "refseq": { "ac": "NP_001029645", "name": "transcriptional repressor RHIT", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029645" }, "gene_names": [ { "name": "ZNF205", "type": "recommended", "evidence": [ { "id": "Q58DK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DK7" } ] }, { "name": "RHIT", "type": "synonym", "evidence": [ { "id": "Q58DK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DK7" } ] }, { "name": "ZNF205", "type": "synonym", "evidence": [ { "id": "NP_001029645", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029645" } ] } ], "protein_names": [ { "name": "Transcriptional repressor RHIT", "type": "recommended", "evidence": [ { "id": "Q58DK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DK7/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein 205", "type": "synonym", "evidence": [ { "id": "Q58DK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DK7/entry#names_and_taxonomy" } ] }, { "name": "transcriptional repressor RHIT", "type": "synonym", "evidence": [ { "id": "NP_001029645", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029645" } ] } ], "function": [ { "annotation": "Transcriptional repressor involved in regulating MPV17L expression. By regulating MPV17L expression, contributes to the regulation of genes involved in H(2)O(2) metabolism and the mitochondrial apoptotic cascade.", "evidence": [ { "database": "UniProtKB", "id": "Q58DK7", "url": "https://www.uniprot.org/uniprotkb/Q58DK7#function" }, { "database": "UniProtKB", "id": "O95201", "url": "https://www.uniprot.org/uniprotkb/O95201#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DK7", "url": "https://www.uniprot.org/uniprotkb/Q58DK7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF205", "url": "https://www.uniprot.org/uniprotkb/Q58DK7", "locus": { "chromosome": "25", "start_pos": 2570663, "end_pos": 2561192, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005572", "url": "https://www.ensembl.org/id/ENSBTAG00000005572" } ] } } ], "crossref": [ { "id": "Q58DK7", "url": "https://alphafold.ebi.ac.uk/entry/Q58DK7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005572", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005572", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514765", "url": "https://www.ncbi.nlm.nih.gov/gene/514765", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514765", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514765", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GHPRQEM", "url": "https://omabrowser.org/oma/group/GHPRQEM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LK24", "url": "https://www.orthodb.org/?gene=A0A3Q1LK24", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3X6I8", "url": "https://www.orthodb.org/?gene=G3X6I8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q58DK7", "url": "https://www.orthodb.org/?gene=Q58DK7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14196", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14196", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14196:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14196:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515:SF58", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515:SF58", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029645", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LK24", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LK24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LK24-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LK24-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXA3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Z2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0Z2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Z2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6I8", "url": "https://www.uniprot.org/uniprotkb/G3X6I8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6I8-1", "url": "https://www.uniprot.org/uniprotkb/G3X6I8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DK7", "url": "https://www.uniprot.org/uniprotkb/Q58DK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DK7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DK7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSADDGGIRAAQDKERARETPGHGHSCQEMLSESEGTVPLGEAWESPHIKMEPEEPHPEGVSQETRAEGARGWVPLSQGTKEKVCFLPGGALPAPQTPVLSREGRTRDRQMAAALLTAWSQMPVTFEDMALYLSREEWGRLDHTQQSFYREVLQKRSGLSLGFPFSRPFWASQVQGKGEAPGSSRQLGHEEEEKRGVVEVDKEELAASLGALGDAKSFKSRMGRAQGEAPRCGQRAASGQNSGPAKDDVQPCPVKEAQLESAPPDTDLPKTQEGHFPEQPREGGTAAPESSEEGLALDSEAGKKTYKCEQCGKAFSWHSHLVTHRRTHTGEKPYACTDCGKRFGRSSHLIQHQIIHTGEKPYTCPSCWKSFSHHSTLIQHQRIHTGEKPYVCDRCAKRFTRRSDLVTHQGTHTGAKPHKCPICGKCFTQSSALVTHQRTHTGVKPYPCPECGKCFSQRSNLIAHNRTHTGEKPYHCLDCGKSFSHSSHLTAHQRTHRGVRPYSCPLCGKSFSRRSNLHRHEKIHTAGPKALAMLMLGAAGTLAAPPPAPT", "length": 550, "header": "sp|Q58DK7-1|RHIT_BOVIN Isoform 1 of Transcriptional repressor RHIT OS=Bos taurus OX=9913 GN=ZNF205 PE=2 SV=1 CANONICAL=Q58DK7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LK24-1", "url": "https://www.uniprot.org/uniprotkb/Q58DK7/entry#A0A3Q1LK24-1", "sequence": { "sequence": "MSADDGGIRAAQDKERARETPGHGHSCQEMLSESEGTVPLGEAWESPHIKMEPEEPHPEGVSQETRAEGARGWVPLSQGTKEKVCFLPGGALPAPQTPVLSREGRTRDRQMAAALLTAWSQMPVTFEDMALYLSREEWGRLDHTQQSFYREVLQKRSGLSLGVVEVDKEELAASLGALGDAKSFKSRMGRAQGEAPRCGQRAASGQNSGPAKDDVQPCPVKEAQLESAPPDTDLPKTQEGHFPEQPREGGTAAPESSEEGLALDSEAGKKTYKCEQCGKAFSWHSHLVTHRRTHTGEKPYACTDCGKRFGRSSHLIQHQIIHTGEKPYTCPSCWKSFSHHSTLIQHQRIHTGEKPYVCDRCAKRFTRRSDLVTHQGTHTGAKPHKCPICGKCFTQSSALVTHQRTHTGVKPYPCPECGKCFSQRSNLIAHNRTHTGEKPYHCLDCGKSFSHSSHLTAHQRTHRGVRPYSCPLCGKSFSRRSNLHRHEKIHTAGPKALAMLMLGAAGTLAAPPPAPT", "length": 516, "header": "tr|A0A3Q1LK24-1|RHIT_BOVIN Computationally mapped isoform of Transcriptional repressor RHIT OS=Bos taurus OX=9913 GN=ZNF205 PE=2 SV=1 CANONICAL=Q58DK7-1" }, "locus": { "chromosome": "25", "start_pos": 2569659, "end_pos": 2562079, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072709.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072709.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056941.1", "url": "https://www.ensembl.org/id/ENSBTAP00000056941.1" } ] } }, { "isoform_ac": "A0AAA9RXA3-1", "url": "https://www.uniprot.org/uniprotkb/Q58DK7/entry#A0AAA9RXA3-1", "sequence": { "sequence": "IHTAMGGVRLTLGRGTPGHGHSCQEMLSESEGTVPLGEAWESPHIKMEPEEPHPEGVSQETRAEGARGWVPLSQGTKEKVCFLPGGALPAPQTPVLSREGRTRDRQMAAALLTAWSQMPVTFEDMALYLSREEWGRLDHTQQSFYREVLQKRSGLSLGFPFSRPFWASQVQGKGEAPGSSRQLGHEEEEKRGVVEVDKEELAASLGALGDAKSFKSRMGRAQGEAPRCGQRAASGQNSGPAKDDVQPCPVKEAQLESAPPDTDLPKTQEGHFPEQPREGGTAAPESSEEGLALDSEAGKKTYKCEQCGKAFSWHSHLVTHRRTHTGEKPYACTDCGKRFGRSSHLIQHQIIHTGEKPYTCPSCWKSFSHHSTLIQHQRIHTGEKPYVCDRCAKRFTRRSDLVTHQGTHTGAKPHKCPICGKCFTQSSALVTHQRTHTGVKPYPCPECGKCFSQRSNLIAHNRTHTGEKPYHCLDCGKSFSHSSHLTAHQRTHRGVRPYSCPLCGKSFSRRSNLHRHEKIHTAGPKALAMLMLGAAGTLAAPPPAPT", "length": 546, "header": "tr|A0AAA9RXA3-1|RHIT_BOVIN Computationally mapped isoform of Transcriptional repressor RHIT OS=Bos taurus OX=9913 GN=ZNF205 PE=2 SV=1 CANONICAL=Q58DK7-1" }, "locus": { "chromosome": "25", "start_pos": 2569659, "end_pos": 2565511, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103337.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103337.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078130.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078130.1" } ] } }, { "isoform_ac": "A0AAA9T0Z2-1", "url": "https://www.uniprot.org/uniprotkb/Q58DK7/entry#A0AAA9T0Z2-1", "sequence": { "sequence": "MSADDGGIRAAQDKERARESADQKLHNMTPGHGHSCQEMLSESEGTVPLGEAWESPHIKMEPEEPHPEGVSQETRAEGARGWVPLSQGTKEKVCFLPGGALPAPQTPVLSREGRTRDRQMAAALLTAWSQMPVTFEDMALYLSREEWGRLDHTQQSFYREVLQKRSGLSLGFPFSRPFWASQVQGKGEAPGSSRQLGHEEEEKRGVVEVDKEELAASLGALGDAKSFKSRMGRAQGEAPRCGQRAASGQNSGPAKDDVQPCPVKEAQLESAPPDTDLPKTQEGHFPEQPREGGTAAPESSEEGLALDSEAGKKTYKCEQCGKAFSWHSHLVTHRRTHTGEKPYACTDCGKRFGRSSHLIQHQIIHTGEKPYTCPSCWKSFSHHSTLIQHQRIHTGEKPYVCDRCAKRFTRRSDLVTHQGTHTGAKPHKCPICGKCFTQSSALVTHQRTHTGVKPYPCPECGKCFSQRSNLIAHNRTHTGEKPYHCLDCGKSFSHSSHLTAHQRTHRGVRPYSCPLCGKSFSRRSNLHRHEKIHTAGPKALAMLMLGAAGTLAAPPPAPT", "length": 559, "header": "tr|A0AAA9T0Z2-1|RHIT_BOVIN Computationally mapped isoform of Transcriptional repressor RHIT OS=Bos taurus OX=9913 GN=ZNF205 PE=2 SV=1 CANONICAL=Q58DK7-1" }, "locus": { "chromosome": "25", "start_pos": 2569659, "end_pos": 2562079, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091834.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091834.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089319.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089319.1" } ] } }, { "isoform_ac": "G3X6I8-1", "url": "https://www.uniprot.org/uniprotkb/Q58DK7/entry#G3X6I8-1", "sequence": { "sequence": "MSADDGGIRAAQDKERARETPGHGHSCQEMLSESEGTVPLGEAWESPHIKMEPEEPHPEGVSQETRAEGARGWVPLSQGTKEKVCFLPGGALPAPQTPVLSREGRTRDRQMAAALLTAWSQMPVTFEDMALYLSREEWGRLDHTQQSFYREVLQKRSGLSLAGFPFSRPFWASQVQGKGEAPGSSRQLGHEEEEKRGVVEVDKEELAASLGALGDAKSFKSRMGRAQGEAPRCGQRAASGQNSGPAKDDVQPCPVKEAQLESAPPDTDLPKTQEGHFPEQPREGGTAAPESSEEGLALDSEAGKKTYKCEQCGKAFSWHSHLVTHRRTHTGEKPYACTDCGKRFGRSSHLIQHQIIHTGEKPYTCPSCWKSFSHHSTLIQHQRIHTGEKPYVCDRCAKRFTRRSDLVTHQGTHTGAKPHKCPICGKCFTQSSALVTHQRTHTGVKPYPCPECGKCFSQRSNLIAHNRTHTGEKPYHCLDCGKSFSHSSHLTAHQRTHRGVRPYSCPLCGKSFSRRSNLHRHEKIHTAGPKALAMLMLGAAGTLAAPPPAPT", "length": 551, "header": "tr|G3X6I8-1|RHIT_BOVIN Computationally mapped isoform of Transcriptional repressor RHIT OS=Bos taurus OX=9913 GN=ZNF205 PE=2 SV=3 CANONICAL=Q58DK7-1" }, "locus": { "chromosome": "25", "start_pos": 2569659, "end_pos": 2562079, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007323.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007323.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007323.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007323.6" } ] } }, { "isoform_ac": "Q58DK7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DK7/entry#Q58DK7-1", "sequence": { "sequence": "MSADDGGIRAAQDKERARETPGHGHSCQEMLSESEGTVPLGEAWESPHIKMEPEEPHPEGVSQETRAEGARGWVPLSQGTKEKVCFLPGGALPAPQTPVLSREGRTRDRQMAAALLTAWSQMPVTFEDMALYLSREEWGRLDHTQQSFYREVLQKRSGLSLGFPFSRPFWASQVQGKGEAPGSSRQLGHEEEEKRGVVEVDKEELAASLGALGDAKSFKSRMGRAQGEAPRCGQRAASGQNSGPAKDDVQPCPVKEAQLESAPPDTDLPKTQEGHFPEQPREGGTAAPESSEEGLALDSEAGKKTYKCEQCGKAFSWHSHLVTHRRTHTGEKPYACTDCGKRFGRSSHLIQHQIIHTGEKPYTCPSCWKSFSHHSTLIQHQRIHTGEKPYVCDRCAKRFTRRSDLVTHQGTHTGAKPHKCPICGKCFTQSSALVTHQRTHTGVKPYPCPECGKCFSQRSNLIAHNRTHTGEKPYHCLDCGKSFSHSSHLTAHQRTHRGVRPYSCPLCGKSFSRRSNLHRHEKIHTAGPKALAMLMLGAAGTLAAPPPAPT", "length": 550, "header": "sp|Q58DK7-1|RHIT_BOVIN Isoform 1 of Transcriptional repressor RHIT OS=Bos taurus OX=9913 GN=ZNF205 PE=2 SV=1 CANONICAL=Q58DK7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 290, "end_pos": 290, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DK7", "url": "https://www.uniprot.org/uniprotkb/Q58DK7" } ], "site_lbl": "Ser290" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DK7", "url": "https://www.uniprot.org/uniprotkb/Q58DK7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:514765", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514765", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GKB8-1", "protein_name": "Transcriptional repressor RHIT", "gene_name": "Zfp13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRFQVMGNPVETCSLGRRRQCPWKPLRSQHMLRQSRAVKGHHRRTGLQEHGALRTKPLSCLVEFFLRPGFPYCPEGDGPESDRWPRRSSLPGPSTVVMLSQMPVTFEDVALYLSREEWGRLDHTQQNFYRDILQGKNGLALGFPFSRPFWVPQVEGKGQASSSSRITGAEERRDLGSGAMEMGKMVPTLAVATLEDTKPIRTRARWAPGEDPKYGQQVASGPATELARDTGEASQLKPAPSEAHPLKTPEYRGPEKPSEREEALTSGEESLVPDSDTGKKTYKCEQCGKGFSWHSHLVTHRRTHTGEKPYTCTDCGKRFGRSSHLIQHQIIHTGEKPYTCPSCWKSFSHHSTLIQHQRIHTGEKPYVCDRCAKRFTRRSDLVTHQGTHTGAKPHKCPICGKCFTQSSALVTHQRTHTGVKPYPCPECGKCFSQRSNLIAHNRTHTGEKPYHCLDCGKSFSHSSHLTAHQRTHRGVRPYSCPLCGKSFSRRSNLHRHEKIHTTGPKALAMLMLGAAAAGALTAPPPAPT", "length": 528 }, "evidence": [ { "id": "Q58DK7", "url": "https://omabrowser.org/oma/group/Q58DK7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O95201-1", "protein_name": "Transcriptional repressor RHIT", "gene_name": "ZNF205", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSADGGGIQDTQDKETPPEVPDRGHPHQEMPSKLGEAVPSGDTQESLHIKMEPEEPHSEGASQEDGAQGAWGWAPLSHGSKEKALFLPGGALPSPRIPVLSREGRTRDRQMAAALLTAWSQMPVTFEDVALYLSREEWGRLDHTQQNFYRDVLQKKNGLSLGFPFSRPFWAPQAHGKGEASGSSRQAGDEKEWRGACTGAVEVGQRVQTSSVAALGNVKPFRTRAGRVQWGVPQCAQEAACGRSSGPAKDSGQPAEPDRTPDAAPPDPSPTEPQEYRVPEKPNEEEKGAPESGEEGLAPDSEVGRKSYRCEQCGKGFSWHSHLVTHRRTHTGEKPYACTDCGKRFGRSSHLIQHQIIHTGEKPYTCPACRKSFSHHSTLIQHQRIHTGEKPYVCDRCAKRFTRRSDLVTHQGTHTGAKPHKCPICAKCFTQSSALVTHQRTHTGVKPYPCPECGKCFSQRSNLIAHNRTHTGEKPYHCLDCGKSFSHSSHLTAHQRTHRGVRPYACPLCGKSFSRRSNLHRHEKIHTTGPKALAMLMLGAAAAGALATPPPAPT", "length": 554 }, "evidence": [ { "id": "Q58DK7", "url": "https://omabrowser.org/oma/group/Q58DK7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P10754-1", "protein_name": "Transcriptional repressor Rhit", "gene_name": "Zfp13", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSADSQSIAATENEEKSHEVPGNVQHCGDMLSGQEETVPLGTSQESTHIKAEPEEPHSEGASREDRTPGTQRWMSPCPGPKDKGPFLPGGVVPSPWTPVLSRGGRTRERKMAAALLTAWSQMPVTFEDVALYLSQEEWGRLDHTQQNFYRDVLQGKNGLALGAVEMGKVVPALAVATLEDTKSIRTRARWAPGEDPKCGQHVASGPGTKLTRDTGKAGQLKPAPSESRPLKTPEDSGPEKPSEGEEALKSGEEGLVPDGDTGKKTYKCEQCGKGFSWHSHLVTHRRTHTGEKPYTCTDCGKRFGRSSHLIQHQIIHTGEKPYTCPSCWKSFSHHSTLIQHQRIHTGEKPYVCDRCAKRFTRRSDLVTHQGTHTGAKPHKCPICSKCFTQSSALVTHQRTHTGVKPYPCPECGKCFSQRSNLIAHNRTHTGEKPYHCLDCGKSFSHSSHLTAHQRTHRGVRPYSCPLCGKSFSRRSNLHRHEKIHTTGPKALAMLMLGAAAAGALTAPPPAST", "length": 512 }, "evidence": [ { "id": "Q58DK7", "url": "https://omabrowser.org/oma/group/Q58DK7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q58DK7", "url": "https://www.uniprot.org/uniprotkb/Q58DK7" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q58DK7", "url": "https://www.uniprot.org/uniprotkb/Q58DK7" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q58DK7", "url": "https://www.uniprot.org/uniprotkb/Q58DK7" } ], "pmid": "" }, { "name": "positive regulation of hydrogen peroxide biosynthetic process", "id": "GO:0010729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010729", "evidence": [ { "database": "UniProtKB", "id": "Q58DK7", "url": "https://www.uniprot.org/uniprotkb/Q58DK7" } ], "pmid": "" }, { "name": "positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "id": "GO:1901030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901030", "evidence": [ { "database": "UniProtKB", "id": "Q58DK7", "url": "https://www.uniprot.org/uniprotkb/Q58DK7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q58DK7", "url": "https://www.uniprot.org/uniprotkb/Q58DK7" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q58DK7", "url": "https://www.uniprot.org/uniprotkb/Q58DK7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q58DK7", "url": "https://www.uniprot.org/uniprotkb/Q58DK7" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q58DK7", "url": "https://www.uniprot.org/uniprotkb/Q58DK7" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q58DK7", "url": "https://www.uniprot.org/uniprotkb/Q58DK7" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q58DK7", "url": "https://www.uniprot.org/uniprotkb/Q58DK7" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "Q58DK7", "url": "https://www.uniprot.org/uniprotkb/Q58DK7" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "Q58DK7", "url": "https://www.uniprot.org/uniprotkb/Q58DK7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 465, "end_pos": 467, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DK7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 550, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DK7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DK7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58DK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DK7" }, { "id": "PRU00119", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00119" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000255", "start_pos": 124, "end_pos": 193, "start_aa": "Val", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 290 ], "sequon_annotation_sites": [ { "start_pos": 465, "end_pos": 467 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "A6QNS9-1", "uniprot_ac": "A6QNS9", "uniprot_id": "DMAC2_BOVIN", "mass": { "chemical_mass": 33185.0, "monoisotopic_mass": 33185.0 }, "refseq": { "ac": "NP_001258937", "name": "distal membrane-arm assembly complex protein 2 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258937" }, "gene_names": [ { "name": "DMAC2", "type": "recommended", "evidence": [ { "id": "A6QNS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNS9" } ] }, { "name": "ATP5SL", "type": "synonym", "evidence": [ { "id": "NP_001258937", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258937" }, { "id": "A6QNS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNS9" } ] }, { "name": "DMAC2", "type": "synonym", "evidence": [ { "id": "NP_001258937", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258937" } ] } ], "protein_names": [ { "name": "Distal membrane-arm assembly complex protein 2", "type": "recommended", "evidence": [ { "id": "A6QNS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNS9/entry#names_and_taxonomy" } ] }, { "name": "ATP synthase subunit s-like protein", "type": "synonym", "evidence": [ { "id": "NP_001258937", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258937" }, { "id": "A6QNS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNS9/entry#names_and_taxonomy" } ] }, { "name": "ATP5S like", "type": "synonym", "evidence": [ { "id": "NP_001258937", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258937" } ] }, { "name": "distal membrane arm assembly complex 2", "type": "synonym", "evidence": [ { "id": "NP_001258937", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258937" } ] }, { "name": "distal membrane-arm assembly complex protein 2 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001258937", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258937" } ] }, { "name": "distal membrane-arm assembly complex protein 2", "type": "synonym", "evidence": [ { "id": "NP_001258937", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258937" } ] } ], "function": [ { "annotation": "Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LKX0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKX0#function" }, { "database": "UniProtKB", "id": "ARBA00057777", "url": "https://www.uniprot.org/uniprotkb/ARBA00057777#function" }, { "database": "UniProtKB", "id": "A6QNS9", "url": "https://www.uniprot.org/uniprotkb/A6QNS9#function" }, { "database": "UniProtKB", "id": "Q9NW81", "url": "https://www.uniprot.org/uniprotkb/Q9NW81#function" }, { "database": "UniProtKB", "id": "A0AAA9SM52", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM52#function" }, { "database": "UniProtKB", "id": "A0AAF6YTN8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTN8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QNS9", "url": "https://www.uniprot.org/uniprotkb/A6QNS9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DMAC2", "url": "https://www.uniprot.org/uniprotkb/A6QNS9", "locus": { "chromosome": "18", "start_pos": 50566982, "end_pos": 50573174, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009449", "url": "https://www.ensembl.org/id/ENSBTAG00000009449" } ] } } ], "crossref": [ { "id": "A6QNS9", "url": "https://alphafold.ebi.ac.uk/entry/A6QNS9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009449", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009449", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "530597", "url": "https://www.ncbi.nlm.nih.gov/gene/530597", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050648", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050648", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530597", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530597", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GFRFAGQ", "url": "https://omabrowser.org/oma/group/GFRFAGQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LKX0", "url": "https://www.orthodb.org/?gene=A0A3Q1LKX0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A6QNS9", "url": "https://www.orthodb.org/?gene=A6QNS9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13382", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13382", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13382:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13382:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-6799198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001258937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258937", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKX0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKX0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKX0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM52", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM52-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YTN8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YTN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTN8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QNS9", "url": "https://www.uniprot.org/uniprotkb/A6QNS9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QNS9-1", "url": "https://www.uniprot.org/uniprotkb/A6QNS9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPRASLRLVAPVWNRGTSGIRGLSKAVDPEGSQKKGRTLLQFLTDHFYDVEAVREYLLRKQVLKVQKKNRSFTYIKERYGPYVAGAYFVLKQGGAVKFRDREWMRANEQGLSSLEFRKLQEVPVEAVDASGCAINYQGLDNLLALKELQSLSLRRCPHVDDWCLGRLYQLADSLQELSLAGCPRISERGLACLHHLQNLRRLDISDLPAVSNPGLTQILVEEMLPHCEVLGADWAQGLKVGPEEQSRDAASSPIPAWPSAPPHQARSLPGCAERPTAHPSGSVGLTQLGGSGWGEGRRA", "length": 301, "header": "sp|A6QNS9-1|DMAC2_BOVIN Isoform 1 of Distal membrane-arm assembly complex protein 2 OS=Bos taurus OX=9913 GN=DMAC2 PE=2 SV=2 CANONICAL=A6QNS9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LKX0-1", "url": "https://www.uniprot.org/uniprotkb/A6QNS9/entry#A0A3Q1LKX0-1", "sequence": { "sequence": "MRANEQGLSSLEFRKLQEVPVEAVDASGCAINYQGLDNLLALKELQSLSLRRCPHVDDWCLGRLYQLADSLQELSLAGCPRISERGLACLHHLQNLRRLDISDLPAVSNPGLTQILVEEMLPHCEVLGADWAQGLKVGPEEQSRDAASSPIPAWPSAPPHQARSLPGCAERPTAHPSGSVGLTQLGGSGWGEGRRA", "length": 196, "header": "tr|A0A3Q1LKX0-1|DMAC2_BOVIN Computationally mapped isoform of Distal membrane-arm assembly complex protein 2 OS=Bos taurus OX=9913 GN=DMAC2 PE=2 SV=1 CANONICAL=A6QNS9-1" }, "locus": { "chromosome": "18", "start_pos": 50568906, "end_pos": 50567839, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085539.1", "url": "https://www.ensembl.org/id/ENSBTAT00000085539.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060352.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060352.1" } ] } }, { "isoform_ac": "A0AAA9SM52-1", "url": "https://www.uniprot.org/uniprotkb/A6QNS9/entry#A0AAA9SM52-1", "sequence": { "sequence": "MEFPRQEYWSGLSFPSPGDLADPGIDPEFPVLQADPSSTEPPRKPFQRSAGKRRGRGHKRAGGLDKMSPFRLHNPSKMAAPRASLRLVAPVWNRGTSGIRGLSKAVDPEGSQKKGRTLLQFLTDHFYDVEAVREYLLRKQVLKVQKKNRSFTYIKERYGPYVAGAYFVLKQGGAVKFRDREWMRANEQGLSSLEFRKLQEVPVEAVDASGCAINYQGLDNLLALKELQSLSLRRCPHVDDWCLGRLYQLADSLQELSLAGCPRISERGLACLHHLQNLRRLDISDLPAVSNPGLTQILVEEMLPHCEVLGADWAQGLKVGPEEQSRDAASSPIPAWPSAPPHQARSLPGCAERPTAHPSGSVGLTQLGGSGWGEGRRA", "length": 378, "header": "tr|A0AAA9SM52-1|DMAC2_BOVIN Computationally mapped isoform of Distal membrane-arm assembly complex protein 2 OS=Bos taurus OX=9913 GN=DMAC2 PE=2 SV=1 CANONICAL=A6QNS9-1" }, "locus": { "chromosome": "18", "start_pos": 50573003, "end_pos": 50567839, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123394.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123394.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083826.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083826.1" } ] } }, { "isoform_ac": "A0AAF6YTN8-1", "url": "https://www.uniprot.org/uniprotkb/A6QNS9/entry#A0AAF6YTN8-1", "sequence": { "sequence": "MSPFRLHNPSKMAAPRASLRLVAPVWNRGTSGIRGLSKAVDPEGSQKKGRTLLQFLTDHFYDVEAVREYLLRKQVLKVQKKNRFRDREWMRANEQGLSSLEFRKLQEVPVEAVDASGCAINYQGLDNLLALKELQSLSLRRCPHVDDWCLGRLYQLADSLQELSLAGCPRISERGLACLHHLQNLRRLDISDLPAVSNPGLTQILVEEMLPHCEVLGADWAQGLKVGPEEQSRDAASSPIPAWPSAPPHQARSLPGCAERPTAHPSGSVGLTQLGGSGWGEGRRA", "length": 285, "header": "tr|A0AAF6YTN8-1|DMAC2_BOVIN Computationally mapped isoform of Distal membrane-arm assembly complex protein 2 OS=Bos taurus OX=9913 GN=DMAC2 PE=2 SV=1 CANONICAL=A6QNS9-1" }, "locus": { "chromosome": "18", "start_pos": 50572805, "end_pos": 50567839, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012434.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012434.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012434.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012434.7" } ] } }, { "isoform_ac": "A6QNS9-1", "url": "https://www.uniprot.org/uniprotkb/A6QNS9/entry#A6QNS9-1", "sequence": { "sequence": "MAAPRASLRLVAPVWNRGTSGIRGLSKAVDPEGSQKKGRTLLQFLTDHFYDVEAVREYLLRKQVLKVQKKNRSFTYIKERYGPYVAGAYFVLKQGGAVKFRDREWMRANEQGLSSLEFRKLQEVPVEAVDASGCAINYQGLDNLLALKELQSLSLRRCPHVDDWCLGRLYQLADSLQELSLAGCPRISERGLACLHHLQNLRRLDISDLPAVSNPGLTQILVEEMLPHCEVLGADWAQGLKVGPEEQSRDAASSPIPAWPSAPPHQARSLPGCAERPTAHPSGSVGLTQLGGSGWGEGRRA", "length": 301, "header": "sp|A6QNS9-1|DMAC2_BOVIN Isoform 1 of Distal membrane-arm assembly complex protein 2 OS=Bos taurus OX=9913 GN=DMAC2 PE=2 SV=2 CANONICAL=A6QNS9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 254, "end_pos": 254, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QNS9", "url": "https://www.uniprot.org/uniprotkb/A6QNS9" } ], "site_lbl": "Ser254" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:530597", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530597", "resource": "KEGG Pathway" }, { "id": "R-BTA-6799198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "resource": "Reactome", "description": "Complex I biogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1SJU6-1", "protein_name": "Distal membrane-arm assembly complex protein 2", "gene_name": "DMAC2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAASRASLHQVARNSATSSIRALSRGVDPEGSQRKGRTLLQFLADHFCDVEAVREYLLRKQALKVHRKNRSFTYIKERYGPYVAGAYFVLKQGGAVKFQDNEWIQSGRGLSSLEFRKFREVPVQAVDASGCAINYQGLDNLLALKELQSLSLQRCPHVDDWCLGRLHQLADSLQELSLAGCPRVSERGLACLHHLQNLRRLDISDLPAVSSPDLTQILVEEMLPNCEVRGSDWAQGLKLGLEEQSRDPASSPVPA", "length": 255 }, "evidence": [ { "id": "A6QNS9", "url": "https://omabrowser.org/oma/group/A6QNS9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XZC5-1", "protein_name": "Distal membrane-arm assembly complex protein 2", "gene_name": "DMAC2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAALAIRGLRGGRIPPPPHPTGPLRGAASGALQRLGEWFYEVEVVLGWAERLRRRRLRRKNAHYSFIQSLHGHNVAAACFAMSCGGRVRFEGQQRWLCADSRGRWSPEVLQFHHVPVVAVDLSGSQLTYDGLDNFVLLTKLQHLDLSGCPHVDDWALGRLHVFGDSLQELSVARCPRVTERGLATLHQLPKLRCLDVGGLAVQSPGLLRILLEEMLPQCRVLGMEMEEGDPPEAPPELGQPPPLCDSAVIGGRVVPKWH", "length": 260 }, "evidence": [ { "id": "A6QNS9", "url": "https://omabrowser.org/oma/group/A6QNS9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q5I0I4-1", "protein_name": "Distal membrane-arm assembly complex protein 2", "gene_name": "Dmac2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAPRAFLHLGAREWHGRARGTHSMSGLATPDSNREKKRTLLQFLSDHFHDVQTLREYLLQKQISKVSMENRSYRKIQERYGPYITGAQFILKQGGAVKFQGRDWIRPNDRGHSIAELQKVPVEAVDASGCAINYQGLSNLLPLKELQFLSLQRCPNLDDWCLSRLYLLAGSLQELSLAGCPRISERGLACLHHLQNLRRLDISDLPAVSHPGLTQILVEEMLPHCEVLGVDWAKSLKLGPDDQPPDTSSPLSS", "length": 254 }, "evidence": [ { "id": "A6QNS9", "url": "https://omabrowser.org/oma/group/A6QNS9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D7K5-1", "protein_name": "Distal membrane-arm assembly complex protein 2", "gene_name": "Dmac2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAPRAVLHLGAREWNGRARRIHGMSELVTPDSSREKKRTLLQFLSDHFQDIQTLREYLLQKQISKVNRENRSFTNIQEKYGPYVAGAVFILKQGGAVKFQDKEEWIRPNNRSHFLAEIQKFQNVPVEAVDASGCAINYQGLSNLLPLKELRSLSLQRCPNLDDWCLSRLYLLAGSLQELSLAGCPRISERGLACLHHLQNLRRLDISDLPAVSHPGLTQILVEEMLPHCEVLGADWAQNLKLEPDKQPPDTSTPLSS", "length": 258 }, "evidence": [ { "id": "A6QNS9", "url": "https://omabrowser.org/oma/group/A6QNS9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NW81-1", "protein_name": "Distal membrane-arm assembly complex protein 2", "gene_name": "DMAC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAPWASLRLVAPMWNGRIRGIHRLGAAVAPEGNQKKKRTILQFLTNYFYDVEALRDYLLQREMYKVHEKNRSYTWLEKQHGPYGAGAFFILKQGGAVKFRDKEWIRPDKYGHFSQEFWNFCEVPVEAVDAGDCDINYEGLDNLLRLKELQSLSLQRCCHVDDWCLSRLYPLADSLQELSLAGCPRISERGLACLHHLQNLRRLDISDLPAVSNPGLTQILVEEMLPNCEVVGVDWAEGLKSGPEEQPRDTASPVPA", "length": 257 }, "evidence": [ { "id": "A6QNS9", "url": "https://omabrowser.org/oma/group/A6QNS9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "R4GEM5-1", "protein_name": "Distal membrane-arm assembly complex protein 2", "gene_name": "dmac2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAAPLVRHAMRRCLAHNCAVTVRRGLRSGATPSVFTRLLLKLDHYFYDVESFLYLKEWWKTKVVKFQNKYFGYVQKRYGAQIGAAYYILAIKGSFRFAGQSQWFRPDSTGMFSFMRSPHGQIEEVDLSGTLINLNGLGNLISQNKLKTLSLRGCPEVDDWFLARLHVFRDSLVELDLSDCTHVTVGGLAALQNLRKLKRLDISGLPRLQCPGLVRILLEEMLPHCQVIGVESEQGMIQPERQEPTDIDDASTQSGLRRS", "length": 259 }, "evidence": [ { "id": "A6QNS9", "url": "https://omabrowser.org/oma/group/A6QNS9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A6QNS9", "url": "https://www.uniprot.org/uniprotkb/A6QNS9" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "A6QNS9", "url": "https://www.uniprot.org/uniprotkb/A6QNS9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "A6QNS9", "url": "https://www.uniprot.org/uniprotkb/A6QNS9" } ], "pmid": "" }, { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "A6QNS9", "url": "https://www.uniprot.org/uniprotkb/A6QNS9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QNS9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 301, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QNS9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QNS9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 254 ], "sequon_annotation_sites": [ { "start_pos": 71, "end_pos": 73 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q58DA5-1", "uniprot_ac": "Q58DA5", "uniprot_id": "NTRI_BOVIN", "mass": { "chemical_mass": 38000.0, "monoisotopic_mass": 38000.0 }, "refseq": { "ac": "NP_001017949", "name": "neurotrimin precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017949" }, "gene_names": [ { "name": "NTM", "type": "recommended", "evidence": [ { "id": "Q58DA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA5" } ] }, { "name": "AXL", "type": "synonym", "evidence": [ { "id": "NP_001017949", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017949" } ] }, { "name": "HNT", "type": "synonym", "evidence": [ { "id": "NP_001017949", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017949" } ] }, { "name": "NTM", "type": "synonym", "evidence": [ { "id": "NP_001017949", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017949" } ] }, { "name": "NT", "type": "synonym", "evidence": [ { "id": "Q58DA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA5" } ] } ], "protein_names": [ { "name": "Neurotrimin", "type": "recommended", "evidence": [ { "id": "Q58DA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA5/entry#names_and_taxonomy" } ] }, { "name": "NTM receptor tyrosine kinase", "type": "synonym", "evidence": [ { "id": "NP_001017949", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017949" } ] }, { "name": "neurotrimin precursor", "type": "synonym", "evidence": [ { "id": "NP_001017949", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017949" } ] } ], "function": [ { "annotation": "Neural cell adhesion molecule.", "evidence": [ { "database": "UniProtKB", "id": "Q58DA5", "url": "https://www.uniprot.org/uniprotkb/Q58DA5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DA5", "url": "https://www.uniprot.org/uniprotkb/Q58DA5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NTM", "url": "https://www.uniprot.org/uniprotkb/Q58DA5", "locus": { "chromosome": "29", "start_pos": 34576438, "end_pos": 35544284, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010032", "url": "https://www.ensembl.org/id/ENSBTAG00000010032" } ] } } ], "crossref": [ { "id": "Q58DA5", "url": "https://alphafold.ebi.ac.uk/entry/Q58DA5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010032", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010032", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534414", "url": "https://www.ncbi.nlm.nih.gov/gene/534414", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013151", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013151", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050876", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050876", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534414", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534414", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VILMCQQ", "url": "https://omabrowser.org/oma/group/VILMCQQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DA5", "url": "https://www.orthodb.org/?gene=Q58DA5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42757", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42757", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42757:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42757:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00047", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00047", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-163125", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001017949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017949", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMG8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMG8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMG8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LU29", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LU29-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU29-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDM1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDM1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDM1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQA4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8W3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8W3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YUQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DA5", "url": "https://www.uniprot.org/uniprotkb/Q58DA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DA5-1", "url": "https://www.uniprot.org/uniprotkb/Q58DA5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGVCGSLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGYYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLVEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASITLFGPGAVSEVSNGTSSRRAGCLWLLPLLVLHLLLKF", "length": 345, "header": "sp|Q58DA5-1|NTRI_BOVIN Isoform 1 of Neurotrimin OS=Bos taurus OX=9913 GN=NTM PE=2 SV=1 CANONICAL=Q58DA5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LMG8-1", "url": "https://www.uniprot.org/uniprotkb/Q58DA5/entry#A0A3Q1LMG8-1", "sequence": { "sequence": "MVLLPLISRAQVKDSGRNSREKRSVGKMWTDLRPCRTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGYYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLVEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASITLFELSEPTSSSLLQEVKTTTLPPGKGPGAVSEVSNGTSSRRAGCLWLLPLLVLHLLLKF", "length": 378, "header": "tr|A0A3Q1LMG8-1|NTRI_BOVIN Computationally mapped isoform of Neurotrimin OS=Bos taurus OX=9913 GN=NTM PE=2 SV=2 CANONICAL=Q58DA5-1" }, "locus": { "chromosome": "29", "start_pos": 35193615, "end_pos": 34577442, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074164.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074164.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058059.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058059.2" } ] } }, { "isoform_ac": "A0A3Q1LU29-1", "url": "https://www.uniprot.org/uniprotkb/Q58DA5/entry#A0A3Q1LU29-1", "sequence": { "sequence": "MKTIQAKMHNSISWAIFTALAALFLFQGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGYYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLVEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASITLFGPGAVSEVSNGTSSRRAGCLWLLPLLVLHLLLKF", "length": 345, "header": "tr|A0A3Q1LU29-1|NTRI_BOVIN Computationally mapped isoform of Neurotrimin OS=Bos taurus OX=9913 GN=NTM PE=2 SV=2 CANONICAL=Q58DA5-1" }, "locus": { "chromosome": "29", "start_pos": 35540101, "end_pos": 34577442, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074067.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074067.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060624.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060624.2" } ] } }, { "isoform_ac": "A0A3Q1MDM1-1", "url": "https://www.uniprot.org/uniprotkb/Q58DA5/entry#A0A3Q1MDM1-1", "sequence": { "sequence": "MGVCGSLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGYYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLVEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASITLFEVKTTTLPPGKGPGAVSEVSNGTSSRRAGCLWLLPLLVLHLLLKF", "length": 356, "header": "tr|A0A3Q1MDM1-1|NTRI_BOVIN Computationally mapped isoform of Neurotrimin OS=Bos taurus OX=9913 GN=NTM PE=2 SV=2 CANONICAL=Q58DA5-1" }, "locus": { "chromosome": "29", "start_pos": 34994005, "end_pos": 34577442, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076299.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076299.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069033.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069033.2" } ] } }, { "isoform_ac": "A0AAA9SQA4-1", "url": "https://www.uniprot.org/uniprotkb/Q58DA5/entry#A0AAA9SQA4-1", "sequence": { "sequence": "MKTIQAKMHNSISWAIFTALAALFLFQGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGYYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLVEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASITLFELSEPTSSSLLQGPGAVSEVSNGTSSRRAGCLWLLPLLVLHLLLKF", "length": 357, "header": "tr|A0AAA9SQA4-1|NTRI_BOVIN Computationally mapped isoform of Neurotrimin OS=Bos taurus OX=9913 GN=NTM PE=2 SV=1 CANONICAL=Q58DA5-1" }, "locus": { "chromosome": "29", "start_pos": 35540101, "end_pos": 34577442, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123779.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123779.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085116.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085116.1" } ] } }, { "isoform_ac": "A0AAA9T8W3-1", "url": "https://www.uniprot.org/uniprotkb/Q58DA5/entry#A0AAA9T8W3-1", "sequence": { "sequence": "MKTIQAKMHNSISWAIFTALAALFLFQGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGYYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLVEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASITLFELSEPTSSSLLQEVKTTTLPPGKGPGAVSEVSNGTSSRRAGCLWLLPLLVLHLLLKF", "length": 368, "header": "tr|A0AAA9T8W3-1|NTRI_BOVIN Computationally mapped isoform of Neurotrimin OS=Bos taurus OX=9913 GN=NTM PE=2 SV=1 CANONICAL=Q58DA5-1" }, "locus": { "chromosome": "29", "start_pos": 35540101, "end_pos": 34577442, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115096.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115096.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095136.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095136.1" } ] } }, { "isoform_ac": "A0AAF6YUQ0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DA5/entry#A0AAF6YUQ0-1", "sequence": { "sequence": "MIGKKRGRWEEVAVEGGTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGYYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLVEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASITLFELSEPTSSSLLQGPGAVSEVSNGTSSRRAGCLWLLPLLVLHLLLKF", "length": 348, "header": "tr|A0AAF6YUQ0-1|NTRI_BOVIN Computationally mapped isoform of Neurotrimin OS=Bos taurus OX=9913 GN=NTM PE=2 SV=1 CANONICAL=Q58DA5-1" }, "locus": { "chromosome": "29", "start_pos": 35247766, "end_pos": 34577442, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013234.8", "url": "https://www.ensembl.org/id/ENSBTAT00000013234.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013234.6", "url": "https://www.ensembl.org/id/ENSBTAP00000013234.6" } ] } }, { "isoform_ac": "Q58DA5-1", "url": "https://www.uniprot.org/uniprotkb/Q58DA5/entry#Q58DA5-1", "sequence": { "sequence": "MGVCGSLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGYYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLVEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASITLFGPGAVSEVSNGTSSRRAGCLWLLPLLVLHLLLKF", "length": 345, "header": "sp|Q58DA5-1|NTRI_BOVIN Isoform 1 of Neurotrimin OS=Bos taurus OX=9913 GN=NTM PE=2 SV=1 CANONICAL=Q58DA5-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 152, "start_aa": "Asn", "end_pos": 152, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn152", "evidence": [ { "id": "Q58DA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 284, "start_aa": "Asn", "end_pos": 284, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn284", "evidence": [ { "id": "Q58DA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 292, "start_aa": "Asn", "end_pos": 292, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn292", "evidence": [ { "id": "Q58DA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 305, "start_aa": "Asn", "end_pos": 305, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn305", "evidence": [ { "id": "Q58DA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 321, "start_aa": "Asn", "end_pos": 321, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn321", "evidence": [ { "id": "Q58DA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 44, "start_aa": "Asn", "end_pos": 44, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn44", "evidence": [ { "id": "Q58DA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 70, "start_aa": "Asn", "end_pos": 70, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn70", "evidence": [ { "id": "Q58DA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DA5#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DA5", "url": "https://www.uniprot.org/uniprotkb/Q58DA5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:534414", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534414", "resource": "KEGG Pathway" }, { "id": "R-BTA-163125", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "resource": "Reactome", "description": "Post-translational modification: synthesis of GPI-anchored proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZXX7-1", "protein_name": "Neurotrimin", "gene_name": "NTM", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDCPHSGSCELGTSVRVRGGSAAQPPAPPCPSEPRTAPGKSRLAQRPAPLPLLLLLFLLPPALPSSSLTRGYWGLPPDAARQAQCSQAAFPGALLISVELRIARLRARPGVPVRSGDATFPKAMDNVTVRQGESATLRCSVDNRVTRVAWLNRSSILYAGNDKWCLDPRVVLLANTKTQYSIQIHDVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKITEISSDISINEGGNVSLTCIATGRPDPTITWRHISPKAVGFISEDEYLEITGITREQSGEYECSASNDVAAPVVQRVKVTVNYPPYISDAKSTGVPVGQKGILMCEASAVPSADFQWYKDDKRLAEGQKGLKVENKAFFSRLTFFNVSEQDYGNYTCVASNQLGNTNASMILYGPGAVHDGNSGAWRRGSCAWLLALPLAQLARQF", "length": 426 }, "evidence": [ { "id": "Q58DA5", "url": "https://omabrowser.org/oma/group/Q58DA5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q99PJ0-1", "protein_name": "Neurotrimin", "gene_name": "Ntm", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGEYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWFKDDKRLVEGKKGVKVENRPFLSKLTFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVSEVNNGTSRRAGCIWLLPLLVLHLLLKF", "length": 344 }, "evidence": [ { "id": "Q58DA5", "url": "https://omabrowser.org/oma/group/Q58DA5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P121-1", "protein_name": "Neurotrimin", "gene_name": "NTM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF", "length": 344 }, "evidence": [ { "id": "Q58DA5", "url": "https://omabrowser.org/oma/group/Q58DA5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VMN9-1", "protein_name": "Dpr-interacting protein eta, isoform D", "gene_name": "DIP-eta", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MQSNFCQCRKQTCALSVILLLILMSQQCYPQRVEVPAEVIVDPKFSSPIVNMTAPVGRDAFLTCVVQDLGPYKVAWLRVDTQTILTIQNHVITKNQRIGIANSEHKTWTMRIKDIKESDKGWYMCQINTDPMKSQMGYLDVVVPPDILDYPTSTDMVVREGSNVTLKCAATGSPEPTITWRRESGVPIELATGEEVMSIEGTDLVIPNVRRHHMGAYLCIASNGVPPSVSKRITLVVHFPPMITVQNQLIGAVEGKGVTLDCESEAYPKSINYWTRERGEIVPPGGKYSANVTEIGGYRNSMRLHINPLTQAEFGSYRCVAKNSLGDTDGTIKLYRIPPNAVNYVENFEARHKGKKRTKSSESHHPARAQEHSGEDMENPGKRKADLSLGAESIDSIYGNSAAGSRRRQDLGGVLLLLLPVAVAVAMSLATAGVMRETQMTLPPQTLTHV", "length": 450 }, "evidence": [ { "id": "Q58DA5", "url": "https://omabrowser.org/oma/group/Q58DA5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "presynaptic active zone membrane", "id": "GO:0048787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048787", "evidence": [ { "database": "UniProtKB", "id": "Q58DA5", "url": "https://www.uniprot.org/uniprotkb/Q58DA5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q58DA5", "url": "https://www.uniprot.org/uniprotkb/Q58DA5" } ], "pmid": "" }, { "name": "postsynaptic density membrane", "id": "GO:0098839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098839", "evidence": [ { "database": "UniProtKB", "id": "Q58DA5", "url": "https://www.uniprot.org/uniprotkb/Q58DA5" } ], "pmid": "" }, { "name": "side of membrane", "id": "GO:0098552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098552", "evidence": [ { "database": "UniProtKB", "id": "Q58DA5", "url": "https://www.uniprot.org/uniprotkb/Q58DA5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of synapse assembly", "id": "GO:0051963", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051963", "evidence": [ { "database": "UniProtKB", "id": "Q58DA5", "url": "https://www.uniprot.org/uniprotkb/Q58DA5" } ], "pmid": "" }, { "name": "heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "id": "GO:0007157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007157", "evidence": [ { "database": "UniProtKB", "id": "Q58DA5", "url": "https://www.uniprot.org/uniprotkb/Q58DA5" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "Q58DA5", "url": "https://www.uniprot.org/uniprotkb/Q58DA5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 284, "end_pos": 286, "annotation": "n_glycosylation_sequon" }, { "start_pos": 292, "end_pos": 294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 305, "end_pos": 307, "annotation": "n_glycosylation_sequon" }, { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DA5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 345, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DA5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DA5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 44, 70, 152, 284, 292, 305, 321 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 152, "end_pos": 154 }, { "start_pos": 284, "end_pos": 286 }, { "start_pos": 292, "end_pos": 294 }, { "start_pos": 305, "end_pos": 307 }, { "start_pos": 321, "end_pos": 323 }, { "start_pos": 44, "end_pos": 46 }, { "start_pos": 70, "end_pos": 72 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 }, { "field": "n_linked_sites", "count": 7 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 7 }, { "field": "exact_n_linked_sites", "count": 7 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 }, { "field": "n_linked_sites", "count": 7 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 7 }, { "field": "exact_n_linked_sites", "count": 7 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DB6-1", "uniprot_ac": "Q58DB6", "uniprot_id": "EYA2_BOVIN", "mass": { "chemical_mass": 58807.0, "monoisotopic_mass": 58807.0 }, "refseq": { "ac": "NP_001030541", "name": "protein phosphatase EYA2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030541" }, "gene_names": [ { "name": "EYA2", "type": "recommended", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ] }, { "name": "EYA2", "type": "synonym", "evidence": [ { "id": "NP_001030541", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030541" } ] } ], "protein_names": [ { "name": "Protein phosphatase EYA2", "type": "recommended", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.48", "type": "synonym", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6/entry#names_and_taxonomy" } ] }, { "name": "Eyes absent homolog 2", "type": "synonym", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6/entry#names_and_taxonomy" } ] }, { "name": "eyes absent 2", "type": "synonym", "evidence": [ { "id": "NP_001030541", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030541" } ] }, { "name": "eyes absent homolog 2", "type": "synonym", "evidence": [ { "id": "NP_001030541", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030541" } ] }, { "name": "protein phosphatase EYA2", "type": "synonym", "evidence": [ { "id": "NP_001030541", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030541" } ] } ], "function": [ { "annotation": "Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.", "evidence": [ { "database": "UniProtKB", "id": "Q58DB6", "url": "https://www.uniprot.org/uniprotkb/Q58DB6#function" }, { "database": "UniProtKB", "id": "O00167", "url": "https://www.uniprot.org/uniprotkb/O00167#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DB6", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EYA2", "url": "https://www.uniprot.org/uniprotkb/Q58DB6", "locus": { "chromosome": "13", "start_pos": 75761781, "end_pos": 75533943, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013336", "url": "https://www.ensembl.org/id/ENSBTAG00000013336" } ] } } ], "crossref": [ { "id": "Q58DB6", "url": "https://alphafold.ebi.ac.uk/entry/Q58DB6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013336", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013336", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02601", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02601", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615264", "url": "https://www.ncbi.nlm.nih.gov/gene/615264", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038102", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038102", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615264", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615264", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "XPNCVNV", "url": "https://omabrowser.org/oma/group/XPNCVNV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DB6", "url": "https://www.orthodb.org/?gene=Q58DB6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10190", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10190", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10190:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10190:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00702", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00702", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693565", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030541", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10684", "url": "https://www.rhea-db.org/rhea/10684", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M2R4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2R4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2R4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2R4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU18-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU18-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T174", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T174", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T174-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T174-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2Y2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Y2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2Y2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Y2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY54", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY54-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY54-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YYQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YYQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DB6", "url": "https://www.uniprot.org/uniprotkb/Q58DB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DB6-1", "url": "https://www.uniprot.org/uniprotkb/Q58DB6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLELLVSASLTVNSDRPGKLKPSRADADVWTLSDREGITTSARSVSQLFARPCPRVPPGQPPSAMAAYSQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTPASGQSPYTYQMHGTAGIYQGANGLTNAAGFGTVHQDYPSYPGFPQSQYSQYYSSSYNPPYVPASSICPSPLSTSTYVLQEASHNIPSQSSESLGGEYNTHNGPSTPAKEGDTDRPPRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTASVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 537, "header": "sp|Q58DB6-1|EYA2_BOVIN Isoform 1 of Protein phosphatase EYA2 OS=Bos taurus OX=9913 GN=EYA2 PE=2 SV=1 CANONICAL=Q58DB6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M2R4-1", "url": "https://www.uniprot.org/uniprotkb/Q58DB6/entry#A0A3Q1M2R4-1", "sequence": { "sequence": "MAEFRYKEMLELLVSASLTVNSDRPGKLKPSRADADVWTLSDREGITTSARSVSQLFARPCPRVPPGQPPSAMAAYSQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTPASGQSPYTYQMHGTAGIYQGANGLTNAAGFGTVHQDYPSYPGFPQSQYSQYYSSSYNPPYVPASSICPSPLSTSTYVLQEASHNIPSQSSESLGGEYNTHNGPSTPAKEGDTDRPPRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTASVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 545, "header": "tr|A0A3Q1M2R4-1|EYA2_BOVIN Computationally mapped isoform of Protein phosphatase EYA2 OS=Bos taurus OX=9913 GN=EYA2 PE=2 SV=2 CANONICAL=Q58DB6-1" }, "locus": { "chromosome": "13", "start_pos": 75761091, "end_pos": 75584781, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086434.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086434.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062406.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062406.2" } ] } }, { "isoform_ac": "A0AAA9SU18-1", "url": "https://www.uniprot.org/uniprotkb/Q58DB6/entry#A0AAA9SU18-1", "sequence": { "sequence": "MEESETEQEGWYKEMLELLVSASLTVNSDRPGKLKPSRADADVWTLSDREGITTSARSVSQLFARPCPRVPPGQPPSAMAAYSQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTPASGQSPYTYQMHGTAGIYQGANGLTNAAGFGTVHQDYPSYPGFPQSQYSQYYSSSYNPPYVPASSICPSPLSTSTYVLQEASHNIPSQSSESLGGEYNTHNGPSTPAKEGDTDRPPRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTASVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 551, "header": "tr|A0AAA9SU18-1|EYA2_BOVIN Computationally mapped isoform of Protein phosphatase EYA2 OS=Bos taurus OX=9913 GN=EYA2 PE=2 SV=1 CANONICAL=Q58DB6-1" }, "locus": { "chromosome": "13", "start_pos": 75761091, "end_pos": 75534018, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123632.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123632.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087505.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087505.1" } ] } }, { "isoform_ac": "A0AAA9T174-1", "url": "https://www.uniprot.org/uniprotkb/Q58DB6/entry#A0AAA9T174-1", "sequence": { "sequence": "MNIPCPRVPPGQPPSAMAAYSQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTPASGQSPYTYQMHGTAGIYQGANGLTNAAGFGTVHQDYPSYPGFPQSQYSQYYSSSYNPPYVPASSICPSPLSTSTYVLQEASHNIPSQSSESLGGEYNTHNGPSTPAKEGDTDRPPRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTASVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 489, "header": "tr|A0AAA9T174-1|EYA2_BOVIN Computationally mapped isoform of Protein phosphatase EYA2 OS=Bos taurus OX=9913 GN=EYA2 PE=2 SV=1 CANONICAL=Q58DB6-1" }, "locus": { "chromosome": "13", "start_pos": 75761091, "end_pos": 75604365, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126863.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126863.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090130.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090130.1" } ] } }, { "isoform_ac": "A0AAA9T2Y2-1", "url": "https://www.uniprot.org/uniprotkb/Q58DB6/entry#A0AAA9T2Y2-1", "sequence": { "sequence": "MLELLVSASLTVNSDRPGKLKPSRADADVWTLSDREGITTSARSVSQLFARPCPRVPPGQPPSAMAAYSQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTPASGQSPYTYQMHGTAGIYQGANGLTNAAGFGTVHQDYPSYPGFPQSQYSQYYSSSYNPPYVPASSICPSPLSTSTYVLQEASHNIPSQSSESLGGEYNTHNGPSTPAKEGDTDRPPRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTASVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 458, "header": "tr|A0AAA9T2Y2-1|EYA2_BOVIN Computationally mapped isoform of Protein phosphatase EYA2 OS=Bos taurus OX=9913 GN=EYA2 PE=2 SV=1 CANONICAL=Q58DB6-1" }, "locus": { "chromosome": "13", "start_pos": 75761091, "end_pos": 75584907, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090004.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090004.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092096.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092096.1" } ] } }, { "isoform_ac": "A0AAA9TY54-1", "url": "https://www.uniprot.org/uniprotkb/Q58DB6/entry#A0AAA9TY54-1", "sequence": { "sequence": "MLELLVSASLTVNSDRPGKLKPSRADADVWTLSDREGITTSARSVSQLFARPCPRVPPGQPPSAMAAYSQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTPASGQSPYTYQMHGTAGIYQGANGLTNAAGFGTVHQDYPSYPGFPQSQYSQYYSSSYNPPYVPASSICPSPLSTSTYVLQEASHNIPSQSSESLGGEYNTHNGPSTPAKEGDTDRPPRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 507, "header": "tr|A0AAA9TY54-1|EYA2_BOVIN Computationally mapped isoform of Protein phosphatase EYA2 OS=Bos taurus OX=9913 GN=EYA2 PE=2 SV=2 CANONICAL=Q58DB6-1" }, "locus": { "chromosome": "13", "start_pos": 75761091, "end_pos": 75584907, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110582.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110582.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103579.2", "url": "https://www.ensembl.org/id/ENSBTAP00000103579.2" } ] } }, { "isoform_ac": "A0AAF6YYQ9-1", "url": "https://www.uniprot.org/uniprotkb/Q58DB6/entry#A0AAF6YYQ9-1", "sequence": { "sequence": "MLELLVSASLTVNSDRPGKLKPSRADADVWTLSDREGRPPAVPCPRVPPGQPPSAMAAYSQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTPASGQSPYTYQMHGTAGIYQGANGLTNAAGFGTVHQDYPSYPGFPQSQYSQYYSSSYNPPYVPASSICPSPLSTSTYVLQEASHNIPSQSSESLGGEYNTHNGPSTPAKEGDTDRPPRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTASVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 528, "header": "tr|A0AAF6YYQ9-1|EYA2_BOVIN Computationally mapped isoform of Protein phosphatase EYA2 OS=Bos taurus OX=9913 GN=EYA2 PE=2 SV=1 CANONICAL=Q58DB6-1" }, "locus": { "chromosome": "13", "start_pos": 75761091, "end_pos": 75584907, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017737.5", "url": "https://www.ensembl.org/id/ENSBTAT00000017737.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017737.4", "url": "https://www.ensembl.org/id/ENSBTAP00000017737.4" } ] } }, { "isoform_ac": "Q58DB6-1", "url": "https://www.uniprot.org/uniprotkb/Q58DB6/entry#Q58DB6-1", "sequence": { "sequence": "MLELLVSASLTVNSDRPGKLKPSRADADVWTLSDREGITTSARSVSQLFARPCPRVPPGQPPSAMAAYSQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTPASGQSPYTYQMHGTAGIYQGANGLTNAAGFGTVHQDYPSYPGFPQSQYSQYYSSSYNPPYVPASSICPSPLSTSTYVLQEASHNIPSQSSESLGGEYNTHNGPSTPAKEGDTDRPPRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTASVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 537, "header": "sp|Q58DB6-1|EYA2_BOVIN Isoform 1 of Protein phosphatase EYA2 OS=Bos taurus OX=9913 GN=EYA2 PE=2 SV=1 CANONICAL=Q58DB6-1" }, "locus": { "chromosome": "13", "start_pos": 75761091, "end_pos": 75584907, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152574.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152574.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104554.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104554.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 124, "start_aa": "Thr", "end_pos": 124, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr124", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DB6", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:615264", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615264", "resource": "KEGG Pathway" }, { "id": "R-BTA-5693565", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693565", "resource": "Reactome", "description": "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K1T5-1", "protein_name": "Eyes absent homolog", "gene_name": "Eya2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLEVVISPSLAASSDWGEHGAAVGALTDREGTAKAASLSVPQLFAKSHPRVPPGQSSAAMAAYGQTQYSTGIQQTPPYTAYPPPAQAYGIPPYSIKTEDSLNHSPSQSGFLSYGPSFSTAPAGQSPYTYPVHSTAGLYQGANGLTNTAGFGSVHQDYPSYPNFPQNQYPQYFSPSYNPPYVPASSLCSSPLSTSTYVLQEAPHNVSQSSESLAGDYNTHNGPSTPAKEGDTDRPHRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSTDGFHSTAPGASLCLGTGVHGGVDWMRKLAFRYRRVKEMYNTYRNNVGGLIGAPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 531 }, "evidence": [ { "id": "Q58DB6", "url": "https://omabrowser.org/oma/group/Q58DB6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A1D5PC43-1", "protein_name": "Eyes absent homolog", "gene_name": "EYA2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGLQLVQTLNSTPFMFLWLFHSSSWDLPFLRKGLGVIKAVRARTGGSRPLSSQNRRAAACPELLERGEERERVGHRSKTPRCHRGQAASPASRYKEMLDLVISPSLTVNKECPDRLKLNLTNIYATAPDDIEGNSKAAPQCPLHLYSTKHYPHIVTVQSFPTMATYGQTQYSAGIQQAAAYTAYPPPAQPYGIPSYSIKTEDSLSHSPGQSGFLSYGSSFSTPTAGQAPYTYQMHGTTGIYQGANGLTNSAGFSAVHQEYSSYPSFPQSQYSQYYSSSYNSPYMSTNSISPSAIPTSTYSLQESSHNITSQSTESLSGEYGTTPAKDIETDRHHRGSDGKVRARSKRSNDPSPTADSEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHIDDVSSDDNGQDLSTYNFSADGFHSSAASANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHALKALNLIHSRPNCVNVLVTTTQLIPALAKVLLYGLGTVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 631 }, "evidence": [ { "id": "Q58DB6", "url": "https://omabrowser.org/oma/group/Q58DB6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SBF5-1", "protein_name": "Eyes absent homolog", "gene_name": "EYA2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLELVISPSLTVNSDRPGKVKLNCAEADVWTLSDIEGISTSAAPSVSPLFARPCPRVLPSQPPTAMAAYGQTQYSAGIQQATPYTTYPPPGQAYGIPSYSIKTEDSLNHSPSQSGFLSYSTSFSTPPTGQSPYTYQMHGTAGIYQGANGLTNAAGFGSVHQDYPSYPGFPQSQYSQYYSSSYNPPYVPASSICSSPLSTSTYVLQEASHSVPNQSSESLGGEYNTHNGPSTPAKEGDPDRPPRASDGKLRGRSKRSSDPSPAADNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFSLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGAPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 538 }, "evidence": [ { "id": "Q58DB6", "url": "https://omabrowser.org/oma/group/Q58DB6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O00167-1", "protein_name": "Protein phosphatase EYA2", "gene_name": "EYA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTSPTGQSPYTYQMHGTTGFYQGGNGLGNAAGFGSVHQDYPSYPGFPQSQYPQYYGSSYNPPYVPASSICPSPLSTSTYVLQEASHNVPNQSSESLAGEYNTHNGPSTPAKEGDTDRPHRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 538 }, "evidence": [ { "id": "Q58DB6", "url": "https://omabrowser.org/oma/group/Q58DB6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O08575-1", "protein_name": "Protein phosphatase EYA2", "gene_name": "Eya2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLEVVTSPSLATSSDWSEHGAAVGTLSDREGIAKSAALSVPQLFVKSHPRVPPGQSSTAMAAYGQTQYSTGIQQAPPYTAYPTPAQAYGIPPYSIKTEDSLNHSPSQSGFLSYGPSFSTAPAGQSPYTYPVHSTAGLYQGANGLTNTAGFGSVHQDYPSYPSFSQNQYPQYFSPSYNPPYVPASSLCSSPLSTSTYVLQEAPHNVPSQSSESLAGDYNTHNGPSTPAKEGDTERPHRASDGKLRGRSKRNSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSTDGFHSTAPGASLCLGTGVHGGVDWMRKLAFRYRRVKEMYNTYRNNVGGLIGAPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL", "length": 532 }, "evidence": [ { "id": "Q58DB6", "url": "https://omabrowser.org/oma/group/Q58DB6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "Q58DB6", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ], "pmid": "" }, { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "Q58DB6", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ], "pmid": "" }, { "name": "histone H2AXY142 phosphatase activity", "id": "GO:0140793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140793", "evidence": [ { "database": "UniProtKB", "id": "Q58DB6", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q58DB6", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q58DB6", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58DB6", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q58DB6", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "Q58DB6", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q58DB6", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q58DB6", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ], "pmid": "" }, { "name": "positive regulation of DNA repair", "id": "GO:0045739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045739", "evidence": [ { "database": "UniProtKB", "id": "Q58DB6", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ], "pmid": "" }, { "name": "negative regulation of extrinsic apoptotic signaling pathway in absence of ligand", "id": "GO:2001240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001240", "evidence": [ { "database": "UniProtKB", "id": "Q58DB6", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 348, "end_pos": 350, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10684", "name": "", "equation": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1ME76-1", "F1MRH9-1", "A0AAF6DLF7-1", "A0AAA9S9Q3-1", "E1BFE2-1", "E1BL76-1", "G3MXS7-1", "A0A3Q1LUB1-1", "A0AAA9THG9-1", "F1N339-1", "F6RY99-1", "A0AAF6YUC8-1", "A0AAA9RTM1-1", "A0AAA9SMJ6-1", "A0A3Q1LZA9-1", "A7MBD1-1", "A5D7P0-1", "Q58DB6-1", "A0AAA9SEK4-1", "E1BDH9-1", "F1MGK4-1", "E1BIH4-1", "A0A3Q1M6K1-1", "E1BIU8-1", "A7MBJ4-1", "A6H730-1", "A0A3Q1MFX2-1", "A0AAA9U0H6-1", "A2VDT1-1", "E1BPU9-1", "P0C591-1", "P11064-1", "Q0IID7-1", "Q2KJ36-1", "Q2T9S4-1", "E1BPA0-1", "A0AAA9TAZ9-1", "Q5BIP9-1", "A0A3Q1M5K4-1", "F1MM08-1", "E1BJR7-1", "Q17QJ3-1", "Q17QM8-1", "F1MD22-1", "F1MI99-1", "F1MP34-1", "F1MGK5-1", "F1MEZ2-1", "F1MQM7-1", "E1BEZ8-1", "A0A3Q1M0B4-1", "A0AAA9S7W5-1", "A0A3Q1N8V6-1", "A0AAA9TFV5-1", "A0A3Q1MBB1-1", "F1MTZ3-1", "A0AAF6Z8C2-1", "F1MDF1-1", "A0AAA9T5N9-1", "E1BKT4-1", "A0A3Q1MH98-1", "F1N6L3-1", "F1MW70-1", "F1MXF2-1", "A0AAA9TWD1-1" ], "evidence": [ { "id": "10684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10684" } ] }, { "id": "R-BTA-5683964", "name": "ATM phosphorylates EYA1-4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MGK4-1", "E1BEI6-1", "A0A3Q1M5K4-1", "A0A3Q1MFX2-1", "Q58DB6-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5683964", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5683964" } ] }, { "id": "R-BTA-5683967", "name": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MGK4-1", "E1BEI6-1", "A0A3Q1M5K4-1", "A0A3Q1MFX2-1", "Q58DB6-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5683967", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5683967" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LUB1", "gene_name": "PTPRD", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] } ] }, { "uniprot_ac": "A0A3Q1LZA9", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B4", "gene_name": "PTPN12", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] } ] }, { "uniprot_ac": "A0A3Q1M5K4", "gene_name": "EYA4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] } ] }, { "uniprot_ac": "A0A3Q1M6K1", "gene_name": "PTPRJ", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] } ] }, { "uniprot_ac": "A0A3Q1MBB1", "gene_name": "TNS2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] } ] }, { "uniprot_ac": "A0A3Q1MFX2", "gene_name": "EYA1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] } ] }, { "uniprot_ac": "A0A3Q1MH98", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] } ] }, { "uniprot_ac": "A0A3Q1MIR9", "gene_name": "KAT5", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "A0A3Q1MIR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIR9" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A3Q1MIR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIR9" } ] } ] }, { "uniprot_ac": "A0A3Q1N8V6", "gene_name": "LOC101903026", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] } ] }, { "uniprot_ac": "A0AAA9RTM1", "gene_name": "DUSP22", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] } ] }, { "uniprot_ac": "A0AAA9S7W5", "gene_name": "PTPRV", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] } ] }, { "uniprot_ac": "A0AAA9S9Q3", "gene_name": "PTPRC", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] } ] }, { "uniprot_ac": "A0AAA9SEK4", "gene_name": "PTPRE", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] } ] }, { "uniprot_ac": "A0AAA9SMJ6", "gene_name": "PTPRH", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] } ] }, { "uniprot_ac": "A0AAA9T5N9", "gene_name": "", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] } ] }, { "uniprot_ac": "A0AAA9TAZ9", "gene_name": "PTPN2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] } ] }, { "uniprot_ac": "A0AAA9TFV5", "gene_name": "PTPN1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] } ] }, { "uniprot_ac": "A0AAA9THG9", "gene_name": "PTPRK", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] } ] }, { "uniprot_ac": "A0AAA9TWD1", "gene_name": "PTPN20", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] } ] }, { "uniprot_ac": "A0AAA9U0H6", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLF7", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] } ] }, { "uniprot_ac": "A0AAF6YUC8", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] } ] }, { "uniprot_ac": "A0AAF6Z8C2", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] } ] }, { "uniprot_ac": "A2VDT1", "gene_name": "PTP4A3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] } ] }, { "uniprot_ac": "A5D7P0", "gene_name": "CDC25C", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] } ] }, { "uniprot_ac": "A6H730", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] } ] }, { "uniprot_ac": "A7MBD1", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] } ] }, { "uniprot_ac": "A7MBJ4", "gene_name": "PTPRF", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] } ] }, { "uniprot_ac": "E1BDH9", "gene_name": "PTPRT", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEZ8", "gene_name": "PTPN14", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] } ] }, { "uniprot_ac": "E1BFE2", "gene_name": "PTPRB", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] } ] }, { "uniprot_ac": "E1BIH4", "gene_name": "PTPN3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] } ] }, { "uniprot_ac": "E1BIU8", "gene_name": "PTPRS", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] } ] }, { "uniprot_ac": "E1BJR7", "gene_name": "PTPN4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] } ] }, { "uniprot_ac": "E1BKT4", "gene_name": "PTPN13", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] } ] }, { "uniprot_ac": "E1BL76", "gene_name": "CDC25B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] } ] }, { "uniprot_ac": "E1BPA0", "gene_name": "PTPRA", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] } ] }, { "uniprot_ac": "E1BPU9", "gene_name": "PTPRM", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] } ] }, { "uniprot_ac": "F1MD22", "gene_name": "PTPRU", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] } ] }, { "uniprot_ac": "F1MDF1", "gene_name": "PTPN18", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MGK4", "gene_name": "EYA3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] } ] }, { "uniprot_ac": "F1MGK5", "gene_name": "PTPRZ1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MRH9", "gene_name": "PTPN21", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] } ] }, { "uniprot_ac": "F1MTZ3", "gene_name": "UBASH3B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": 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}, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] } ] }, { "uniprot_ac": "F1N6L3", "gene_name": "PTPN22", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] } ] }, { "uniprot_ac": "F6RY99", "gene_name": "PTPN6", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F6RY99", "database": 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{ "id": "NP_001015663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015663", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYE6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYE6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYE6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MV66", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MV66-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV66-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z9X3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9X3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z9X3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9X3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH36", "url": "https://www.uniprot.org/uniprotkb/F1MH36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH36-1", "url": "https://www.uniprot.org/uniprotkb/F1MH36-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E953-1", "url": "https://www.uniprot.org/uniprotkb/Q5E953-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVENNKNADNDWFRLESNKEGTRWFGKCWYIHDLLKYEFDIEFDIPITYPTTAPEIAVPELDGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGLGPWLAVEIPDLIQKGVIQHKEKCSQ", "length": 167, "header": "sp|Q5E953-1|UFC1_BOVIN Isoform 1 of Ubiquitin-fold modifier-conjugating enzyme 1 OS=Bos taurus OX=9913 GN=UFC1 PE=2 SV=1 CANONICAL=Q5E953-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LYE6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E953/entry#A0A3Q1LYE6-1", "sequence": { "sequence": "MPQASEHRLGRTREPPLNIQPRVGSKLPFAPRARSKERRNPAPGPNPMLRPLPPRPGPPEERLKKLELGRGRTSGPRPSGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLRPMGIALGGHRGTGELGAALSRLALRPEPPPLRRSTSLRRLGGFPGPPTLFSIRTEPPTPHGSFHVISARPSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILASSPAPHPPRLGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPRCL", "length": 536, "header": "tr|A0A3Q1LYE6-1|UFC1_BOVIN Computationally mapped isoform of Ubiquitin-fold modifier-conjugating enzyme 1 OS=Bos taurus OX=9913 GN=UFC1 PE=2 SV=2 CANONICAL=Q5E953-1" }, "locus": { "chromosome": "3", "start_pos": 8336617, "end_pos": 8331766, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081662.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081662.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062274.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062274.2" } ] } }, { "isoform_ac": "A0A3Q1MV66-1", "url": "https://www.uniprot.org/uniprotkb/Q5E953/entry#A0A3Q1MV66-1", "sequence": { "sequence": "MMADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVENNKNADNDWFRLESNKEGTRWFGKCWYIHDLLKYEFDIEFDIPITYPTTAPEIAVPELDGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGLGPWLAVEIPDLIQKGVIQHKEKCSQ", "length": 168, "header": "tr|A0A3Q1MV66-1|UFC1_BOVIN Computationally mapped isoform of Ubiquitin-fold modifier-conjugating enzyme 1 OS=Bos taurus OX=9913 GN=UFC1 PE=2 SV=1 CANONICAL=Q5E953-1" }, "locus": { "chromosome": "3", "start_pos": 8362436, "end_pos": 8338623, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071045.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071045.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058818.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058818.1" } ] } }, { "isoform_ac": "A0AAA9SUA1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E953/entry#A0AAA9SUA1-1", "sequence": { "sequence": "MPVLGELPQELHRRLAGQRSKWGTDGTAMAETVVHSAVMGLLLMASEAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILASSPAPHPPRLGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPRCL", "length": 412, "header": "tr|A0AAA9SUA1-1|UFC1_BOVIN Computationally mapped isoform of Ubiquitin-fold modifier-conjugating enzyme 1 OS=Bos taurus OX=9913 GN=UFC1 PE=2 SV=1 CANONICAL=Q5E953-1" }, "locus": { "chromosome": "3", "start_pos": 8335506, "end_pos": 8331766, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100550.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100550.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087726.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087726.1" } ] } }, { "isoform_ac": "A0AAF6Z9X3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E953/entry#A0AAF6Z9X3-1", "sequence": { "sequence": "MADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVENNKNADNDWFRLESNKEGTRWFGKCWYIHDLLKYEFDIEFDIPITYPTTAPEIAVPELDGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGVQPVASTMPQASEHRLGRTREPPLNIQPRVGSKLPFAPRARSKERRNPAPGPNPMLRPLPPRPGPPEERLKKLELGRGRTSGPRPSGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLRPMGIALGGHRGTGELGAALSRLALRPEPPPLRRSTSLRRLGGFPGPPTLFSIRTEPPTPHGSFHVISARPSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILASSPAPHPPRLGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPRCL", "length": 713, "header": "tr|A0AAF6Z9X3-1|UFC1_BOVIN Computationally mapped isoform of Ubiquitin-fold modifier-conjugating enzyme 1 OS=Bos taurus OX=9913 GN=UFC1 PE=2 SV=1 CANONICAL=Q5E953-1" }, "locus": { "chromosome": "3", "start_pos": 8341952, "end_pos": 8331766, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028928.5", "url": "https://www.ensembl.org/id/ENSBTAT00000028928.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028928.4", "url": "https://www.ensembl.org/id/ENSBTAP00000028928.4" } ] } }, { "isoform_ac": "F1MH36-1", "url": "https://www.uniprot.org/uniprotkb/Q5E953/entry#F1MH36-1", "sequence": { "sequence": "MPQASEHRLGRTREPPLNIQPRVGSKLPFAPRARSKERRNPAPGPNPMLRPLPPRPGPPEERLKKLELGRGRTSGPRPSGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLRPMGIALGGHRGTGELGAALSRLALRPEPPPLRRSTSLRRLGGFPGPPTLFSIRTEPPTPHGSFHVISARPSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILASSPAPHPPRLGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPRCL", "length": 565, "header": "tr|F1MH36-1|UFC1_BOVIN Computationally mapped isoform of Ubiquitin-fold modifier-conjugating enzyme 1 OS=Bos taurus OX=9913 GN=UFC1 PE=2 SV=1 CANONICAL=Q5E953-1" }, "locus": { "chromosome": "3", "start_pos": 8336617, "end_pos": 8331766, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029184.4", "url": "https://www.ensembl.org/id/ENSBTAT00000029184.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029184.2", "url": "https://www.ensembl.org/id/ENSBTAP00000029184.2" } ] } }, { "isoform_ac": "Q5E953-1", "url": "https://www.uniprot.org/uniprotkb/Q5E953/entry#Q5E953-1", "sequence": { "sequence": "MADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVENNKNADNDWFRLESNKEGTRWFGKCWYIHDLLKYEFDIEFDIPITYPTTAPEIAVPELDGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGLGPWLAVEIPDLIQKGVIQHKEKCSQ", "length": 167, "header": "sp|Q5E953-1|UFC1_BOVIN Isoform 1 of Ubiquitin-fold modifier-conjugating enzyme 1 OS=Bos taurus OX=9913 GN=UFC1 PE=2 SV=1 CANONICAL=Q5E953-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:537221", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537221", "resource": "KEGG Pathway" }, { "id": "R-BTA-5357786", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5357786", "resource": "Reactome", "description": "TNFR1-induced proapoptotic signaling" }, { "id": "R-BTA-5357905", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5357905", "resource": "Reactome", "description": "Regulation of TNFR1 signaling" }, { "id": "R-BTA-5357956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5357956", "resource": "Reactome", "description": "TNFR1-induced NF-kappa-B signaling pathway" }, { "id": "R-BTA-5689880", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689880", "resource": "Reactome", "description": "Ub-specific processing proteases" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VSC7-1", "protein_name": "Ubiquitin-fold modifier-conjugating enzyme 1", "gene_name": "UFC1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVENNKNADNDWFRLESNKEGTRWFGKCWYIHDLLKYEFDIEFDIPITYPTTAPEIAVPELDGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGLGPWLAVEIPDLIQKGVIQHKEKCNQ", "length": 167 }, "evidence": [ { "id": "Q5E953", "url": "https://omabrowser.org/oma/group/Q5E953/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7JRX6-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "gene_name": "Usp21", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPQASEHRLGRTREPPVNVQPRVGAKIPFPPRARSKERRNPVPGPNSVLRPLPPRPGPPDERLKKVELGRGRTSGSRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLRPMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLLSIRTEPPASHGSYHVLPARPSEPFYSDDKMARHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILASGPVPSPPRRGGALHEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFSLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSTSRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPRCL", "length": 565 }, "evidence": [ { "id": "Q5E953", "url": "https://omabrowser.org/oma/group/Q5E953/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "B2GUX4-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 21", "gene_name": "Usp21", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPQASEHRLGRTREPPVNVQPRVGAKIPFPPRARSKERRNPVPGPNSMLRPLPPRPGPPDERLKKLDLGRGRTSGSRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLTRSKSVSSGDLRPMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLLSIRTEPPPSHGSFHMISARPSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILASGPVPSPPRRGGALHEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFSLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSTSRGSIKKSSVGVDFPLQRLSLGDFASDKVGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPRCL", "length": 565 }, "evidence": [ { "id": "Q5E953", "url": "https://omabrowser.org/oma/group/Q5E953/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S196-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "gene_name": "USP21", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPQASEHRLGRTREPPLNVQPRVGSKLPFAPRARSKERRNPAPGPNPMLRPLPPRPGPPEERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLRPMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLLSIRTEPPTSHGSFHVISARPSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILASSPAPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFSLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPIYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPRCL", "length": 565 }, "evidence": [ { "id": "Q5E953", "url": "https://omabrowser.org/oma/group/Q5E953/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HU13-1", "protein_name": "Ubiquitin-fold modifier-conjugating enzyme 1", "gene_name": "Ufc1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVENNKNSDNDWFRLESNKEGTRWFGKCWYIHDLLKYEFDIEFEIPITYPTTAPEIAVPELDGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGLGPWLAVEIPDLIQKGVIQHKEKCNQ", "length": 167 }, "evidence": [ { "id": "Q5E953", "url": "https://omabrowser.org/oma/group/Q5E953/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q1ZXC9-1", "protein_name": "Ubiquitin-fold modifier-conjugating enzyme 1", "gene_name": "ufc1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDNHTKQTVQQIPLLTVKAGPRDGDKWIDRLKEEYQALIKYVEINKKADNDWFNIESNPLGTRWQGKCWYIYNFKKYEFDLEFDMPVTYPETAPEIAIPELDGKTEKMYRGGKICLTIHFKPLWSRNVPHFGIAHALALGLAPWLAAEVPHLVDNGIIKHKEDK", "length": 164 }, "evidence": [ { "id": "Q5E953", "url": "https://omabrowser.org/oma/group/Q5E953/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6BBI8-1", "protein_name": "Ubiquitin-fold modifier-conjugating enzyme 1", "gene_name": "Ufc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVENNKNADNDWFRLESNKEGTRWFGKCWYIHDFLKYEFDIEFEIPITYPTTAPEIAVPELDGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGLGPWLAVEVPDLIQKGVIQHKEKCNQ", "length": 167 }, "evidence": [ { "id": "Q5E953", "url": "https://omabrowser.org/oma/group/Q5E953/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6DEN0-1", "protein_name": "Ubiquitin-fold modifier-conjugating enzyme 1", "gene_name": "ufc1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MADEATRKAVSEIPLLKTNSGPRDKELWVQRLREEYLALIKYVENNKAADNDWFRLESNKEGTRWFGKCWYIHELLKYEFDMEFDIPVTYPATAPEVAIPELDGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGLGPWLAVEIPDLIAKGLIQHKDQNS", "length": 166 }, "evidence": [ { "id": "Q5E953", "url": "https://omabrowser.org/oma/group/Q5E953/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q7K1Z5-1", "protein_name": "Ubiquitin-fold modifier-conjugating enzyme 1", "gene_name": "Ufc1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVDDSTRKTLSNIPLLQIRAGPREKDVWVQRLKEEYQALIKYVENNKQSGSDWFRLESNKEGTKWFGKCWYMHNLLKYEFDVEFDIPVTYPTTAPEIALPELDGKTAKMYRGGKICLTDHFKPLWARNVPKFGIAHAMALGLAPWLAVEIPDLIEKGIITYKEK", "length": 164 }, "evidence": [ { "id": "Q5E953", "url": "https://omabrowser.org/oma/group/Q5E953/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9CR09-1", "protein_name": "Ubiquitin-fold modifier-conjugating enzyme 1", "gene_name": "Ufc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVENNKNSDNDWFRLESNKEGTRWFGKCWYIHDFLKYEFDIEFEIPITYPTTAPEIAVPELDGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGLGPWLAVEVPDLIQKGVIQHKEKCSQ", "length": 167 }, "evidence": [ { "id": "Q5E953", "url": "https://omabrowser.org/oma/group/Q5E953/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9QZL6-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 21", "gene_name": "Usp21", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPQASEHRLGRTREPPVNVQPRVGAKIPFPPRARSKERRNPVPGPNSMLRPLPPRPGPPDERLKKLELGRGRTSGSRPRGPLRADHGVPLPGSPPPAVALPLPSRTNLARSKSVSSGDLRPMGIALGGHRGAGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLLSIRTEPPTSHGSFHMISARPSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILASGPVPSPPRRGGGALHEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFSLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSTSRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPLRCL", "length": 566 }, "evidence": [ { "id": "Q5E953", "url": "https://omabrowser.org/oma/group/Q5E953/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9SXC8-1", "protein_name": "Ubiquitin-fold modifier-conjugating enzyme 1", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEGWDPNTKSTLTRIPLLTTKAGPRDGAAWTQRLKEEYKSLIAYTQMNKSNDNDWFRISASNPEGTRWTGKCWYVHNLLKYEFDLQFDIPITYPATAPELELPEIDGKTQKMYRGGKICLTVHFKPLWAKNCPRFGIAHALCLGLAPWLAAEIPILVDSGAIKHKDDAATSAES", "length": 174 }, "evidence": [ { "id": "Q5E953", "url": "https://omabrowser.org/oma/group/Q5E953/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9UK80-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 21", "gene_name": "USP21", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPDERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLRPMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASHGSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPRCL", "length": 565 }, "evidence": [ { "id": "Q5E953", "url": "https://omabrowser.org/oma/group/Q5E953/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Y3C8-1", "protein_name": "Ubiquitin-fold modifier-conjugating enzyme 1", "gene_name": "UFC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVENNKNADNDWFRLESNKEGTRWFGKCWYIHDLLKYEFDIEFDIPITYPTTAPEIAVPELDGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGLGPWLAVEIPDLIQKGVIQHKEKCNQ", "length": 167 }, "evidence": [ { "id": "Q5E953", "url": "https://omabrowser.org/oma/group/Q5E953/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "UFM1 transferase activity", "id": "GO:0071568", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071568", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "pmid": "" }, { "name": "UFM1 conjugating enzyme activity", "id": "GO:0061657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061657", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "pmid": "" }, { "name": "cysteine-type deubiquitinase activity", "id": "GO:0004843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004843", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "pmid": "" }, { "name": "deNEDDylase activity", "id": "GO:0019784", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019784", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "pmid": "" }, { "name": "response to endoplasmic reticulum stress", "id": "GO:0034976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034976", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "pmid": "" }, { "name": "protein ufmylation", "id": "GO:0071569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071569", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "pmid": "" }, { "name": "reticulophagy", "id": "GO:0061709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061709", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "pmid": "" }, { "name": "protein K69-linked ufmylation", "id": "GO:1990592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990592", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "pmid": "" }, { "name": "regulation of type II interferon production", "id": "GO:0032649", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032649", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "pmid": "" }, { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "pmid": "" }, { "name": "protein deubiquitination", "id": "GO:0016579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016579", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "pmid": "" }, { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "Q5E953", "url": "https://www.uniprot.org/uniprotkb/Q5E953" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-140978", "name": "TRADD:TRAF2:RIP1 binds FADD", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q1RMU2-1", "Q2KHV7-1", "A0ABI0NXY8-1", "G3N2I1-1", "Q5E953-1", "A6QR55-1", "E1B9D9-1" ], "evidence": [ { "id": "R-BTA-140978", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-140978" } ] }, { "id": "R-BTA-5357776", "name": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q95KV1-1", "Q95KV0-1", "A0ABI0NI58-1", "Q1RMU2-1", "Q2KHV7-1", "A0ABI0NXY8-1", "E1BMK3-1", "G3N2I1-1", "Q5E953-1", "A6QR55-1", "E1B9D9-1" ], "evidence": [ { "id": "R-BTA-5357776", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5357776" } ] }, { "id": "R-BTA-5357845", "name": "K63polyUb-RIPK1 is deubiquitinated", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0ABI0NI58-1", "Q1RMU2-1", "Q2KHV7-1", "A0ABI0NXY8-1", "G3N2I1-1", "Q5E953-1", "A6QR55-1", "E1B9D9-1" ], "evidence": [ { "id": "R-BTA-5357845", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5357845" } ] }, { "id": "R-BTA-5357860", "name": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0ABI0NI58-1", "Q1RMU2-1", "Q2KHV7-1", "A0ABI0NXY8-1", "E1BMK3-1", "G3N2I1-1", "Q5E953-1", "A2VDU3-1", "A6QR55-1", "E1B9D9-1" ], "evidence": [ { "id": "R-BTA-5357860", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5357860" } ] }, { "id": "R-BTA-5690157", "name": "USP16,USP21 deubiquitinate Histone H2A", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E953-1" ], "evidence": [ { "id": "R-BTA-5690157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5690157" } ] }, { "id": "R-BTA-5690159", "name": "USP21 deubiquitinates RIPK1,DDX58", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0ABI0NX25-1", "Q5E953-1" ], "evidence": [ { "id": "R-BTA-5690159", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5690159" } ] }, { "id": "R-BTA-6783177", "name": "USP21 deubiquitinates GATA3,IL33", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E953-1" ], "evidence": [ { "id": "R-BTA-6783177", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6783177" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0ABI0NI58", "gene_name": "XIAP", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0ABI0NI58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NI58" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0ABI0NI58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NI58" } ] } ] }, { "uniprot_ac": "A0ABI0NX25", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXY8", "gene_name": "OTUD7B", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "A0ABI0NXY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXY8" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "A0ABI0NXY8", "database": "UniProtKB", "url": 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"UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DF9", "url": "https://www.uniprot.org/uniprotkb/Q58DF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DF9-1", "url": "https://www.uniprot.org/uniprotkb/Q58DF9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKSDLRYFFLFCIQVEILAGEFNDSAASEMFIFHNGGVQILCKYPDTVRQFKMQLLKGDNVLCDLTKTKENEDTVSIRNLNVCKFQLSNNSVSFFLYNLDSSYASYYICKLSIFDPPPFQVDILSREYLNIYESELCCQLKFWLPIGCAAFVTVCVFGCVLMYWLTKKKYPTSVHDPNSEYMFMAAVNTAKKPAPTDVTRNLELPGTQA", "length": 209, "header": "sp|Q58DF9-1|ICOS_BOVIN Isoform 1 of Inducible T-cell costimulator OS=Bos taurus OX=9913 GN=ICOS PE=2 SV=1 CANONICAL=Q58DF9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T0I7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DF9/entry#A0AAA9T0I7-1", "sequence": { "sequence": "MKSDLRYFFLFCIQVEILAGEFNDSAASEMFIFHNGGVQILCKYPDTVRQFKMQLLKGDNVLCDLTKTKENEDTVSIRNLNVCKFQLSNNSVSFFLYNLDSSYASYYICKLSIFDPPPFQVDILSREYLNIYESELCCQLKFWLPIGCAAFVTVCVFGCVLMYWLTKKM", "length": 169, "header": "tr|A0AAA9T0I7-1|ICOS_BOVIN Computationally mapped isoform of Inducible T-cell costimulator OS=Bos taurus OX=9913 GN=ICOS PE=2 SV=1 CANONICAL=Q58DF9-1" }, "locus": { "chromosome": "2", "start_pos": 92167918, "end_pos": 92144644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120196.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120196.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091214.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091214.1" } ] } }, { "isoform_ac": "A0AAF6Z9R4-1", "url": "https://www.uniprot.org/uniprotkb/Q58DF9/entry#A0AAF6Z9R4-1", "sequence": { "sequence": "MKSDLRYFFLFCIQVEILAGEFNDSAASEMFIFHNGGVQILCKYPDTVRQFKMQLLKGDNVLCDLTKTKENEDTVSIRNLNVCKFQLSNNSVSFFLYNLDSSYASYYICKLSIFDPPPFQVDILSREYLNIYGCAAFVTVCVFGCVLMYWLTKKKYPTSVHDPNSEYMFMAAVNTAKKPAPTDVTRNLELPGTQA", "length": 195, "header": "tr|A0AAF6Z9R4-1|ICOS_BOVIN Computationally mapped isoform of Inducible T-cell costimulator OS=Bos taurus OX=9913 GN=ICOS PE=2 SV=1 CANONICAL=Q58DF9-1" }, "locus": { "chromosome": "2", "start_pos": 92167953, "end_pos": 92144644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028775.6", "url": "https://www.ensembl.org/id/ENSBTAT00000028775.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028775.5", "url": "https://www.ensembl.org/id/ENSBTAP00000028775.5" } ] } }, { "isoform_ac": "Q58DF9-1", "url": "https://www.uniprot.org/uniprotkb/Q58DF9/entry#Q58DF9-1", "sequence": { "sequence": "MKSDLRYFFLFCIQVEILAGEFNDSAASEMFIFHNGGVQILCKYPDTVRQFKMQLLKGDNVLCDLTKTKENEDTVSIRNLNVCKFQLSNNSVSFFLYNLDSSYASYYICKLSIFDPPPFQVDILSREYLNIYESELCCQLKFWLPIGCAAFVTVCVFGCVLMYWLTKKKYPTSVHDPNSEYMFMAAVNTAKKPAPTDVTRNLELPGTQA", "length": 209, "header": "sp|Q58DF9-1|ICOS_BOVIN Isoform 1 of Inducible T-cell costimulator OS=Bos taurus OX=9913 GN=ICOS PE=2 SV=1 CANONICAL=Q58DF9-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 23, "start_aa": "Asn", "end_pos": 23, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn23", "evidence": [ { "id": "Q58DF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DF9#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 89, "start_aa": "Asn", "end_pos": 89, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn89", "evidence": [ { "id": "Q58DF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DF9#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DF9", "url": "https://www.uniprot.org/uniprotkb/Q58DF9" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:507026", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507026", "resource": "KEGG Pathway" }, { "id": "R-BTA-1257604", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1257604", "resource": "Reactome", "description": "PIP3 activates AKT signaling" }, { "id": "R-BTA-6811558", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811558", "resource": "Reactome", "description": "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" }, { "id": "R-BTA-9927354", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9927354", "resource": "Reactome", "description": "Co-stimulation by ICOS" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1V2P7-1", "protein_name": "Inducible T-cell costimulator", "gene_name": "ICOS", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKSDLWYFFLFCFQVEVLMGEVNDSAKSEMFMFHDGGLQIVCKYPDTVRQFKMQLLKGKNILCDLTKTKGSGNTVSITNVNLCQFQLSNNSVSFFLYNLDSSYASYYICELSIFDPPPFQVDILSKEYLNIYESQLCCQLKFWLLLGCAAFVVVYIIGCVLTCWLTKKKYRPSVHDPNSEYMFMAAVNTTKKAGPTDVTRNLVRSGTRA", "length": 209 }, "evidence": [ { "id": "Q58DF9", "url": "https://omabrowser.org/oma/group/Q58DF9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZTP5-1", "protein_name": "Inducible T-cell costimulator", "gene_name": "ICOS", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNESFLQPGSVLPPTSRTGTERSLLHYWISAATWSSATSLDVGSLATSSKQAHTYFRRLMPLCQASMKTVAVTFCLLCFQFEALCGVDTCSSRLCKNIDKLQVSDPQGIVEFENGNFKLIFQNPKNVNEFSMTLLKGRERKAICALHMNNKKAVPESNVTYCQAEHSDTSTTFILTNLDRKHIDTYTCCLESLLPPPYIHCHLKETYLYIQDKEDCSSQGIMSWIIIGLIAFALIFCVCFVVACHLRNKNQQCESNSHEYNSEYMPMAAVNAAKKPRI", "length": 278 }, "evidence": [ { "id": "Q58DF9", "url": "https://omabrowser.org/oma/group/Q58DF9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9R1T7-1", "protein_name": "Inducible T-cell costimulator", "gene_name": "Icos", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKPYFSCVFVFCFLIKLLTGELNDLANHRMFSFHDGGVQISCNYPETVQQLKMQLFKDREVLCDLTKTKGSGNTVSIKNPMSCPYQLSNNSVSFFLDNADSSQGSYFLCSLSIFDPPPFQEKNLSGGYLLIYESQLCCQLKLWLPVGCAAFVAALLFGCIFIVWFAKKKYRSSVHDPNSEYMFMAAVNTNKKSRLAGMTS", "length": 200 }, "evidence": [ { "id": "Q58DF9", "url": "https://omabrowser.org/oma/group/Q58DF9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9WVS0-1", "protein_name": "Inducible T-cell costimulator", "gene_name": "Icos", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKPYFCRVFVFCFLIRLLTGEINGSADHRMFSFHNGGVQISCKYPETVQQLKMRLFREREVLCELTKTKGSGNAVSIKNPMLCLYHLSNNSVSFFLNNPDSSQGSYYFCSLSIFDPPPFQERNLSGGYLHIYESQLCCQLKLWLPVGCAAFVVVLLFGCILIIWFSKKKYGSSVHDPNSEYMFMAAVNTNKKSRLAGVTS", "length": 200 }, "evidence": [ { "id": "Q58DF9", "url": "https://omabrowser.org/oma/group/Q58DF9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y6W8-1", "protein_name": "Inducible T-cell costimulator", "gene_name": "ICOS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKSGLWYFFLFCLRIKVLTGEINGSANYEMFIFHNGGVQILCKYPDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKSLKFCHSQLSNNSVSFFLYNLDHSHANYYFCNLSIFDPPPFKVTLTGGYLHIYESQLCCQLKFWLPIGCAAFVVVCILGCILICWLTKKKYSSSVHDPNGEYMFMRAVNTAKKSRLTDVTL", "length": 199 }, "evidence": [ { "id": "Q58DF9", "url": "https://omabrowser.org/oma/group/Q58DF9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q58DF9", "url": "https://www.uniprot.org/uniprotkb/Q58DF9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "T cell costimulation", "id": "GO:0031295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031295", "evidence": [ { "database": "UniProtKB", "id": "Q58DF9", "url": "https://www.uniprot.org/uniprotkb/Q58DF9" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "Q58DF9", "url": "https://www.uniprot.org/uniprotkb/Q58DF9" } ], "pmid": "" }, { "name": "T cell tolerance induction", "id": "GO:0002517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002517", "evidence": [ { "database": "UniProtKB", "id": "Q58DF9", "url": "https://www.uniprot.org/uniprotkb/Q58DF9" } ], "pmid": "" }, { "name": "T follicular helper cell differentiation", "id": "GO:0061470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061470", "evidence": [ { "database": "UniProtKB", "id": "Q58DF9", "url": "https://www.uniprot.org/uniprotkb/Q58DF9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling receptor activity", "id": "GO:0038023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "database": "UniProtKB", "id": "Q58DF9", "url": "https://www.uniprot.org/uniprotkb/Q58DF9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 23, "end_pos": 25, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DF9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 209, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DF9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DF9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 23, 89 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 23, "end_pos": 25 }, { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "A6QQS3-1", "uniprot_ac": "A6QQS3", "uniprot_id": "CBY2_BOVIN", "mass": { "chemical_mass": 52473.0, "monoisotopic_mass": 52473.0 }, "refseq": { "ac": "NP_001095767", "name": "protein chibby homolog 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095767" }, "gene_names": [ { "name": "CBY2", "type": "recommended", "evidence": [ { "id": "A6QQS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQS3" } ] }, { "name": "CBY2", "type": "synonym", "evidence": [ { "id": "NP_001095767", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095767" } ] }, { "name": "SPERT", "type": "synonym", "evidence": [ { "id": "NP_001095767", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095767" }, { "id": "A6QQS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQS3" } ] } ], "protein_names": [ { "name": "Protein chibby homolog 2", "type": "recommended", "evidence": [ { "id": "A6QQS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQS3/entry#names_and_taxonomy" } ] }, { "name": "Spermatid-associated protein", "type": "synonym", "evidence": [ { "id": "A6QQS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQS3/entry#names_and_taxonomy" } ] }, { "name": "protein chibby homolog 2", "type": "synonym", "evidence": [ { "id": "NP_001095767", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095767" } ] }, { "name": "spermatid associated", "type": "synonym", "evidence": [ { "id": "NP_001095767", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095767" } ] }, { "name": "spermatid-associated protein", "type": "synonym", "evidence": [ { "id": "NP_001095767", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095767" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QQS3", "url": "https://www.uniprot.org/uniprotkb/A6QQS3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CBY2", "url": "https://www.uniprot.org/uniprotkb/A6QQS3", "locus": { "chromosome": "12", "start_pos": 15782807, "end_pos": 15647244, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018580", "url": "https://www.ensembl.org/id/ENSBTAG00000018580" } ] } } ], "crossref": [ { "id": "A6QQS3", "url": "https://alphafold.ebi.ac.uk/entry/A6QQS3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018580", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018580", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616053", "url": "https://www.ncbi.nlm.nih.gov/gene/616053", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028118", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028118", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616053", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616053", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QNEWSIW", "url": "https://omabrowser.org/oma/group/QNEWSIW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QQS3", "url": "https://www.orthodb.org/?gene=A6QQS3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21533", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21533", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21533:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21533:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14645", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14645", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095767", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T4U4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4U4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4U4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4U4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQS3", "url": "https://www.uniprot.org/uniprotkb/A6QQS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQS3-1", "url": "https://www.uniprot.org/uniprotkb/A6QQS3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQS3-2", "url": "https://www.uniprot.org/uniprotkb/A6QQS3-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPLECSECFGDQLLHRTYTWHLTLHSRPNFTRKRDTRSESLEIPINVVLPQRGTAEPFLRLHNLYPTPRCARQAALPRLSRRVVSQHSYPLNRFSSVPLDPMERPTSQADLELDYNPPRVQLSDEMFVFQDGRWVSENCRLQSPYFSPSSSFHHKLHHKRLAKECLLQENKTLREENRALREENRMLRKENKILQVFWEEHQAALGRDDSRASSPLLHKDNASSLEAMKKETALQAHRGRENSTLQLLREENRALQQLLEQRKAYWAQPDEKAASTEEIKPISSPHEEPHGLLPDPGPGLPSPFEEPKGLPAPPDDSKTLRALREMVSTLSAQPGEEVGKGGPGLPDGSQSLELLREMNQALQALREENQSLQVLRDENRLLQEENRALHALREEHRLFQEENKALWENNKLKLQQKLVIDTVTEVTARMEMLIEELYAFMPAKSKDPKKPSRV", "length": 455, "header": "sp|A6QQS3-1|CBY2_BOVIN Isoform 1 of Protein chibby homolog 2 OS=Bos taurus OX=9913 GN=CBY2 PE=2 SV=2 CANONICAL=A6QQS3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T4U4-1", "url": "https://www.uniprot.org/uniprotkb/A6QQS3/entry#A0AAA9T4U4-1", "sequence": { "sequence": "MLSPHGAWCPRNQPWRGTAEPFLRLHNLYPTPRCARQAALPRLSRRVVSQHSYPLNRFSSVPLDPMERPTSQADLELDYNPPRVQLSDEMFVFQDGRWVSENCRLQSPYFSPSSSFHHKLHHKRLAKECLLQENKTLREENRALREENRMLRKENKILQVFWEEHQAALGRDDSRASSPLLHKDNASSLEAMKKETALQAHRGRENSTLQLLREENRALQQLLEQRKAYWAQPDEKAASTEEIKPISSPHEEPHGLLPDPGPGLPSPFEEPKGLPAPPDDSKTLRALREMVSTLSAQPGEEVGKGGPGLPDGSQSLELLREMNQALQALREENQSLQVLRDENRLLQEENRALHALREEHRLFQEENKALWENNKLKLQQKLVIDTVTEVTARMEMLIEELYAFMPAKSKDPKKPSRV", "length": 418, "header": "tr|A0AAA9T4U4-1|CBY2_BOVIN Computationally mapped isoform of Protein chibby homolog 2 OS=Bos taurus OX=9913 GN=CBY2 PE=2 SV=1 CANONICAL=A6QQS3-1" }, "locus": { "chromosome": "12", "start_pos": 15782201, "end_pos": 15768713, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135584.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135584.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091523.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091523.1" } ] } }, { "isoform_ac": "A6QQS3-1", "url": "https://www.uniprot.org/uniprotkb/A6QQS3/entry#A6QQS3-1", "sequence": { "sequence": "MSPLECSECFGDQLLHRTYTWHLTLHSRPNFTRKRDTRSESLEIPINVVLPQRGTAEPFLRLHNLYPTPRCARQAALPRLSRRVVSQHSYPLNRFSSVPLDPMERPTSQADLELDYNPPRVQLSDEMFVFQDGRWVSENCRLQSPYFSPSSSFHHKLHHKRLAKECLLQENKTLREENRALREENRMLRKENKILQVFWEEHQAALGRDDSRASSPLLHKDNASSLEAMKKETALQAHRGRENSTLQLLREENRALQQLLEQRKAYWAQPDEKAASTEEIKPISSPHEEPHGLLPDPGPGLPSPFEEPKGLPAPPDDSKTLRALREMVSTLSAQPGEEVGKGGPGLPDGSQSLELLREMNQALQALREENQSLQVLRDENRLLQEENRALHALREEHRLFQEENKALWENNKLKLQQKLVIDTVTEVTARMEMLIEELYAFMPAKSKDPKKPSRV", "length": 455, "header": "sp|A6QQS3-1|CBY2_BOVIN Isoform 1 of Protein chibby homolog 2 OS=Bos taurus OX=9913 GN=CBY2 PE=2 SV=2 CANONICAL=A6QQS3-1" }, "locus": {} }, { "isoform_ac": "A6QQS3-2", "url": "https://www.uniprot.org/uniprotkb/A6QQS3/entry#A6QQS3-2", "sequence": { "sequence": "MAVQPEGLKCRVEESNAERGTAEPFLRLHNLYPTPRCARQAALPRLSRRVVSQHSYPLNRFSSVPLDPMERPTSQADLELDYNPPRVQLSDEMFVFQDGRWVSENCRLQSPYFSPSSSFHHKLHHKRLAKECLLQENKTLREENRALREENRMLRKENKILQVFWEEHQAALGRDDSRASSPLLHKDNASSLEAMKKETALQAHRGRENSTLQLLREENRALQQLLEQRKAYWAQPDEKAASTEEIKPISSPHEEPHGLLPDPGPGLPSPFEEPKGLPAPPDDSKTLRALREMVSTLSAQPGEEVGKGGPGLPDGSQSLELLREMNQALQALREENQSLQVLRDENRLLQEENRALHALREEHRLFQEENKALWENNKLKLQQKLVIDTVTEVTARMEMLIEELYAFMPAKSKDPKKPSRV", "length": 421, "header": "sp|A6QQS3-2|CBY2_BOVIN Isoform 2 of Protein chibby homolog 2 OS=Bos taurus OX=9913 GN=CBY2 PE=2 SV=2 CANONICAL=A6QQS3-1" }, "locus": { "chromosome": "12", "start_pos": 15782201, "end_pos": 15770003, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053702.2", "url": "https://www.ensembl.org/id/ENSBTAT00000053702.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050226.1", "url": "https://www.ensembl.org/id/ENSBTAP00000050226.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 124, "end_pos": 124, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QQS3", "url": "https://www.uniprot.org/uniprotkb/A6QQS3" } ], "site_lbl": "Ser124" }, { "start_pos": 144, "end_pos": 144, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QQS3", "url": "https://www.uniprot.org/uniprotkb/A6QQS3" } ], "site_lbl": "Ser144" }, { "start_pos": 148, "end_pos": 148, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QQS3", "url": "https://www.uniprot.org/uniprotkb/A6QQS3" } ], "site_lbl": "Ser148" }, { "start_pos": 150, "end_pos": 150, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QQS3", "url": "https://www.uniprot.org/uniprotkb/A6QQS3" } ], "site_lbl": "Ser150" }, { "start_pos": 211, "end_pos": 211, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QQS3", "url": "https://www.uniprot.org/uniprotkb/A6QQS3" } ], "site_lbl": "Ser211" }, { "start_pos": 225, "end_pos": 225, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QQS3", "url": "https://www.uniprot.org/uniprotkb/A6QQS3" } ], "site_lbl": "Ser225" }, { "start_pos": 276, "end_pos": 276, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QQS3", "url": "https://www.uniprot.org/uniprotkb/A6QQS3" } ], "site_lbl": "Ser276" }, { "start_pos": 332, "end_pos": 332, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QQS3", "url": "https://www.uniprot.org/uniprotkb/A6QQS3" } ], "site_lbl": "Ser332" }, { "start_pos": 41, "end_pos": 41, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QQS3", "url": "https://www.uniprot.org/uniprotkb/A6QQS3" } ], "site_lbl": "Ser41" }, { "start_pos": 86, "end_pos": 86, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QQS3", "url": "https://www.uniprot.org/uniprotkb/A6QQS3" } ], "site_lbl": "Ser86" }, { "start_pos": 89, "end_pos": 89, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QQS3", "url": "https://www.uniprot.org/uniprotkb/A6QQS3" } ], "site_lbl": "Ser89" }, { "start_pos": 97, "end_pos": 97, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QQS3", "url": "https://www.uniprot.org/uniprotkb/A6QQS3" } ], "site_lbl": "Ser97" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616053", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616053", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2ML27-1", "protein_name": "Protein chibby homolog 2", "gene_name": "Cby2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSPLECSECFGDQLMHRTYTWHLTLHSRPIFTRKRDTRSESLEIPINVVLPQRGTTEPFLRLHNLYSIPRCSRQTALPRMSRRVVSQHSYPLNRFSSVPFDPMERPTSQADLELDYNPPRVQLSDEMFVFQDGRWVNENCRLQSPYFSPSSSFHHKLHHKRLAKEHLLQEENKSLRDENRALRDENKALRKENKILQIFWEEHKVTLGHEENPSSSPLMHKDTASQEVVKKDNVTLPVQRSKENTLQLIREENRALQQLLEQRQAYWAQAEDNATSAEEGKPTSSPKEEPHNPGLLPEQSPGLSSPFEEHKGPPPTQEDSKTLRALREMVNNLSGPSGEEEGKVGPNLSDSAQPLQLLREMNQALQALREENRLLQEENRALHVLREEHRVFQEENKALWENNKLKLQQRLVIDTVTEVTARMEMLIEELYAFMPAKNSKDPKKPSRV", "length": 448 }, "evidence": [ { "id": "A6QQS3", "url": "https://omabrowser.org/oma/group/A6QQS3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A1KXM5-1", "protein_name": "Protein chibby homolog 2", "gene_name": "CBY2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTMSAFDLTKQSTRCTKPEMDCVFPRMKVRDETFTFIDGKWVNEVHCQPTFVPQRRLLSKKTENEWSIWEENRALWEENQVLRIENRMLWEENKALQYLQSQNKGVQLVYSDTIQQSLQKDHKLSPFFPERHLGFQVSPGNKALQLVRERSSVLEFFHRQNRTVPTIWKDQQAIVVHEENKGASSVQKDTENTTAAGEGSLGPTCQEEHDAKEESTTPTQNDTKIAPSTEDDNEILQALQDLYQILRVFLKEKCLSDDRESLHALQDESKFFQEEYKKLKLQLNNVKNTVSDITTQMEMLEKELIAITFPIYEEAGKNMANEYQLGEM", "length": 328 }, "evidence": [ { "id": "A6QQS3", "url": "https://omabrowser.org/oma/group/A6QQS3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q32MG2-1", "protein_name": "Protein chibby homolog 2", "gene_name": "Cby2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSPLECSECFGDQLLHKTYTWHLTLHSRPNFTRKRDTRSESLEIPVNVILPQRGTEPFLRLHNLYSTPRCSRQAALPRMSRRVASQHSYPLNRFSSMPFDPMERPTSQADLELDYNPPRVQLSDEMFVFQDGRWVNESCRLQPPYFSPPSSFHHKLHHRRLAKEYQLQEENKSLRDENRALRDENKALRKENKILQVFWEEHKVTLGHEESQTSSLLHKDTTSQEVVKRDNTTLPAQRSKESTLQLIREENRALQQLLEQRQAYWAQAEENAASTEEGKSTSSPKEESHNSGLLPDQSTNHSSPFEDPKVPPTTQEDSKTLRALREMVNNLSGASGEEDGKVGPNLPDSAQPLQLLREMNQALQALQEENRLLQEENRALHILREEHRVFQEENKALWENNKLKLQQRLVIDTVTEVTARMEMLIEELYAFMPAKNNKDPKKPSRV", "length": 446 }, "evidence": [ { "id": "A6QQS3", "url": "https://omabrowser.org/oma/group/A6QQS3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6AXV6-1", "protein_name": "Protein chibby homolog 2", "gene_name": "Cby2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSPLECSECFGDQLMHRTYTWHLTLHSRPNFTRKREIRSESLEIPINVILPQRGTEPFLRLHNLYTTPRCSRQAAMPRISRRVASQHSYPLNRFSSMPFDPMERPTSQADLELDYNPPRVQLSDEMFVFQDGRWVNESCRLQSPYFSPSSSFHHKLHHKRMAKEYLLQEENKSLRDENRALRDENKALRKENKILQVFWEEHKVTLGHEESQTSSPLLHKDTTSQEVVKKDNATLPAQRSKENTLQFIREENRALQQLLEQRQAYWAQAEESATSAEEGKPTSSPKEEPHNSGLLPDQSTSHSSHFEEPKASPTTQEDSKTLRALREMVTNLSGPSGEEEGKAGPNLTDSAQPLQLLREMNQALQALREENRLLQEENRALHAMREEHRVFQEENKALWENNKLKLQQRLVIDTVTEVTARMEMLIEELYAFMPAKNNKDPKKPSRV", "length": 447 }, "evidence": [ { "id": "A6QQS3", "url": "https://omabrowser.org/oma/group/A6QQS3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8NA61-1", "protein_name": "Protein chibby homolog 2", "gene_name": "CBY2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSPLECSECFGDQLLHRTYTWQLTLHSRPNYTRKRDTRSESLEIPISVVLPQRGTAEPFPRLHNLYSTPRCAQQAALPRLSRRMASQHSYPLNRFSSVPLDPMERPMSQADLELDYNPPRVQLSDEMFVFQDGRWVNENCRLQSPYFSPSASFHHKLHHKRLAKECMLQEENKSLREENKALREENRMLSKENKILQVFWEEHKASLGREESRAPSPLLHKDSASLEVVKKDHVALQVPRGKEDSTLQLLREENRALQQLLEQKQAYWAQAEDTAAPAEESKPAPSPHEEPCSPGLLQDQGSGLSSRFEEPKGPPARQEDSKELRALRKMVSNMSGPSGEEEAKVGPGLPDGCQPLQLLREMRQALQALLKENRLLQEENRTLQVLRAEHRGFQEENKALWENNKLKLQQKLVIDTVTEVTARMEMLIEELYAFMPARSQDPKKPSRV", "length": 448 }, "evidence": [ { "id": "A6QQS3", "url": "https://omabrowser.org/oma/group/A6QQS3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A6QQS3", "url": "https://www.uniprot.org/uniprotkb/A6QQS3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" }, { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 30, "end_pos": 32, "annotation": "n_glycosylation_sequon" }, { "start_pos": 370, "end_pos": 372, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QQS3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 455, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QQS3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QQS3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 41, 86, 89, 97, 124, 144, 148, 150, 211, 225, 276, 332 ], "sequon_annotation_sites": [ { "start_pos": 171, "end_pos": 173 }, { "start_pos": 222, "end_pos": 224 }, { "start_pos": 243, "end_pos": 245 }, { "start_pos": 30, "end_pos": 32 }, { "start_pos": 370, "end_pos": 372 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 12 }, { "field": "total_sites", "count": 12 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q56JZ5-1", "uniprot_ac": "Q56JZ5", "uniprot_id": "EIF3H_BOVIN", "mass": { "chemical_mass": 39906.0, "monoisotopic_mass": 39906.0 }, "refseq": { "ac": "NP_001020493", "name": "eukaryotic translation initiation factor 3 subunit H", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020493" }, "gene_names": [ { "name": "EIF3H", "type": "recommended", "evidence": [ { "id": "Q56JZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JZ5" } ] }, { "name": "EIF3H", "type": "synonym", "evidence": [ { "id": "NP_001020493", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020493" } ] }, { "name": "EIF3S3", "type": "synonym", "evidence": [ { "id": "NP_001020493", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020493" }, { "id": "Q56JZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JZ5" } ] } ], "protein_names": [ { "name": "Eukaryotic translation initiation factor 3 subunit H", "type": "recommended", "evidence": [ { "id": "Q56JZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JZ5/entry#names_and_taxonomy" } ] }, { "name": "Eukaryotic translation initiation factor 3 subunit 3", "type": "synonym", "evidence": [ { "id": "Q56JZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JZ5/entry#names_and_taxonomy" } ] }, { "name": "eIF-3-gamma", "type": "synonym", "evidence": [ { "id": "NP_001020493", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020493" }, { "id": "Q56JZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JZ5/entry#names_and_taxonomy" } ] }, { "name": "eIF3 p40 subunit", "type": "synonym", "evidence": [ { "id": "NP_001020493", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020493" }, { "id": "Q56JZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JZ5/entry#names_and_taxonomy" } ] }, { "name": "eIF3h", "type": "synonym", "evidence": [ { "id": "Q56JZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JZ5/entry#names_and_taxonomy" } ] }, { "name": "eukaryotic translation initiation factor 3 subunit 3", "type": "synonym", "evidence": [ { "id": "NP_001020493", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020493" } ] }, { "name": "eukaryotic translation initiation factor 3 subunit H", "type": "synonym", "evidence": [ { "id": "NP_001020493", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020493" } ] }, { "name": "eukaryotic translation initiation factor 3, subunit 3 (gamma)", "type": "synonym", "evidence": [ { "id": "NP_001020493", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020493" } ] }, { "name": "eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa", "type": "synonym", "evidence": [ { "id": "NP_001020493", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020493" } ] } ], "function": [ { "annotation": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ5", "url": "https://www.uniprot.org/uniprotkb/Q56JZ5#function" }, { "database": "HAMAP", "id": "MF_03007", "url": "https://hamap.expasy.org/signature/MF_03007" }, { "database": "UniProtKB", "id": "A0AAF6YZK2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZK2#function" }, { "database": "UniProtKB", "id": "ARBA00057041", "url": "https://www.uniprot.org/uniprotkb/ARBA00057041#function" }, { "database": "UniProtKB", "id": "A0A3Q1LMU9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMU9#function" }, { "database": "UniProtKB", "id": "A0AAA9T6G4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6G4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q56JZ5", "url": "https://www.uniprot.org/uniprotkb/Q56JZ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF3H", "url": "https://www.uniprot.org/uniprotkb/Q56JZ5", "locus": { "chromosome": "14", "start_pos": 47716322, "end_pos": 47571828, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014032", "url": "https://www.ensembl.org/id/ENSBTAG00000014032" } ] } } ], "crossref": [ { "id": "Q56JZ5", "url": "https://alphafold.ebi.ac.uk/entry/Q56JZ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014032", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014032", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08065", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08065", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506873", "url": "https://www.ncbi.nlm.nih.gov/gene/506873", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000555", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000555", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027524", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027524", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037518", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037518", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050242", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050242", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506873", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506873", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WYQSTYF", "url": "https://omabrowser.org/oma/group/WYQSTYF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LMU9", "url": "https://www.orthodb.org/?gene=A0A3Q1LMU9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q56JZ5", "url": "https://www.orthodb.org/?gene=Q56JZ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10410", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10410", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01398", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01398", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19445", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19445", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001020493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020493", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMU9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMU9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMU9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6G4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6G4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6G4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6G4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YZK2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZK2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YZK2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YZK2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JZ5", "url": "https://www.uniprot.org/uniprotkb/Q56JZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JZ5-1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASRKEGTGSSATSSSSTTGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGTEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKGNITFEHMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLGKTLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEEDLSKLFKPHQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNS", "length": 352, "header": "sp|Q56JZ5-1|EIF3H_BOVIN Isoform 1 of Eukaryotic translation initiation factor 3 subunit H OS=Bos taurus OX=9913 GN=EIF3H PE=2 SV=1 CANONICAL=Q56JZ5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LMU9-1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ5/entry#A0A3Q1LMU9-1", "sequence": { "sequence": "MASRKEGTGSSATSSSSTTGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGTEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKGNITFEHMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLGKTLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEEDLSKLFKPHQPPARMDSLLIAGDLPNTGIEPTSLMSPALSENPLS", "length": 344, "header": "tr|A0A3Q1LMU9-1|EIF3H_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 3 subunit H OS=Bos taurus OX=9913 GN=EIF3H PE=2 SV=2 CANONICAL=Q56JZ5-1" }, "locus": { "chromosome": "14", "start_pos": 47682890, "end_pos": 47572172, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084896.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084896.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061238.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061238.2" } ] } }, { "isoform_ac": "A0AAA9T6G4-1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ5/entry#A0AAA9T6G4-1", "sequence": { "sequence": "MASRKEGTGSSATSSSSTTGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGTEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKGNITFEHMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLGKTLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEEDLSKLFKPHQPPARMDSLLIAGDCQVQDQGAGKLPGFGAW", "length": 339, "header": "tr|A0AAA9T6G4-1|EIF3H_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 3 subunit H OS=Bos taurus OX=9913 GN=EIF3H PE=2 SV=1 CANONICAL=Q56JZ5-1" }, "locus": { "chromosome": "14", "start_pos": 47715470, "end_pos": 47572172, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101566.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101566.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091372.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091372.1" } ] } }, { "isoform_ac": "A0AAF6YZK2-1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ5/entry#A0AAF6YZK2-1", "sequence": { "sequence": "KHNAHAQGVPLRRKMASRKEGTGSSATSSSSTTGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGTEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKGNITFEHMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLGKTLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEEDLSKLFKPHQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNS", "length": 366, "header": "tr|A0AAF6YZK2-1|EIF3H_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 3 subunit H OS=Bos taurus OX=9913 GN=EIF3H PE=2 SV=1 CANONICAL=Q56JZ5-1" }, "locus": { "chromosome": "14", "start_pos": 47669291, "end_pos": 47571828, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018645.4", "url": "https://www.ensembl.org/id/ENSBTAT00000018645.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018645.2", "url": "https://www.ensembl.org/id/ENSBTAP00000018645.2" } ] } }, { "isoform_ac": "Q56JZ5-1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ5/entry#Q56JZ5-1", "sequence": { "sequence": "MASRKEGTGSSATSSSSTTGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGTEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKGNITFEHMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLGKTLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEEDLSKLFKPHQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNS", "length": 352, "header": "sp|Q56JZ5-1|EIF3H_BOVIN Isoform 1 of Eukaryotic translation initiation factor 3 subunit H OS=Bos taurus OX=9913 GN=EIF3H PE=2 SV=1 CANONICAL=Q56JZ5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 183, "end_pos": 183, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6G4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6G4" }, { "database": "UniProtKB", "id": "A0A3Q1LMU9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMU9" }, { "database": "UniProtKB", "id": "Q56JZ5", "url": "https://www.uniprot.org/uniprotkb/Q56JZ5" } ], "site_lbl": "Ser183" }, { "start_pos": 3, "end_pos": 3, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ5", "url": "https://www.uniprot.org/uniprotkb/Q56JZ5" } ], "site_lbl": "Ser3" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506873", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506873", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-72649", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "resource": "Reactome", "description": "Translation initiation complex formation" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "resource": "Reactome", "description": "Formation of the ternary complex, and subsequently, the 43S complex" }, { "id": "R-BTA-72702", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "resource": "Reactome", "description": "Ribosomal scanning and start codon recognition" } ], "orthologs": [ { "uniprot_canonical_ac": "O15372-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit H", "gene_name": "EIF3H", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASRKEGTGSTATSSSSTAGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGTEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKANITFEYMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLGKNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEEDLSKLFKPPQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNN", "length": 352 }, "evidence": [ { "id": "Q56JZ5", "url": "https://omabrowser.org/oma/group/Q56JZ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54UD0-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit H", "gene_name": "eif3H", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDIDEQIIQDYSNSKLDVVQIDGLVVLKIIKQCKEYLPELVPGQLLGLDIGTSLEVSNCFPFPPRDQEDENSESIADYQLEMMRFLREVNIDSNTVGWYTPTYLNSFFNESVIETQYNYQATINQKCVVIVYDPIKTSQGTLSLKCYRLTQSFMELFKDQSFSRERLDQANLSFNDIFEQIPIKIHNSQLINALLYEFDGASNNLTNSFDRLNISNNIYLEKVVEGMTDCLESLNQELNKVYINQRNIQTQKTNYIQQKFLEGQKVDEDELASMIKPLNPPSKLTSLLLTNQINNYTDQIHSFSGNSLTKLSLLKDLQK", "length": 319 }, "evidence": [ { "id": "Q56JZ5", "url": "https://omabrowser.org/oma/group/Q56JZ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5ZLE6-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit H", "gene_name": "EIF3H", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASRKEGSGAAGGGFGASKGKGKAATTGDSAVKQVQIDGLVVLKIIKHYQEEGQGNEVVQGVLLGLVVDDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKANIAYENMFEEVPIVIKNSYLINVMLWELEKKSAVADRHELLSLASSNHLGKSLQLLMDRVDEMSQDIVKYNTYLRNVSKQQQQKHQYQQRRQQENLQRQSRGEAPLPEEDINKLFKPPQPPARMESLLIAGQINTYCQNIKEFNAQNLGKLFMAQALQDYNN", "length": 348 }, "evidence": [ { "id": "Q56JZ5", "url": "https://omabrowser.org/oma/group/Q56JZ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6AXJ2-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit H-A", "gene_name": "eif3ha", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": 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"sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q58CZ9-1", "uniprot_ac": "Q58CZ9", "uniprot_id": "ATTY_BOVIN", "mass": { "chemical_mass": 49691.0, "monoisotopic_mass": 49691.0 }, "refseq": { "ac": "NP_001029762", "name": "tyrosine aminotransferase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029762" }, "gene_names": [ { "name": "TAT", "type": "recommended", "evidence": [ { "id": "Q58CZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9" } ] }, { "name": "TAT", "type": "synonym", "evidence": [ { "id": "NP_001029762", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029762" } ] } ], "protein_names": [ { "name": "Tyrosine aminotransferase", "type": "recommended", "evidence": [ { "id": "Q58CZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9/entry#names_and_taxonomy" } ] }, { "name": 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Converts tyrosine to p-hydroxyphenylpyruvate.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TG21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG21#function" }, { "database": "UniProtKB", "id": "PIRNR000517", "url": "https://www.uniprot.org/uniprotkb/PIRNR000517#function" }, { "database": "UniProtKB", "id": "A0A3Q1MLP1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLP1#function" }, { "database": "UniProtKB", "id": "A0A3Q1MP71", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP71#function" }, { "database": "UniProtKB", "id": "A0AAF6YJB0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJB0#function" }, { "database": "UniProtKB", "id": "A0ABI0NJE3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJE3#function" } ] }, { "annotation": "Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity for phenylalanine (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ9", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CZ9", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAT", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9", "locus": { "chromosome": "18", "start_pos": 39493865, "end_pos": 39478264, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002214", "url": "https://www.ensembl.org/id/ENSBTAG00000002214" } ] } } ], "crossref": [ { "id": "Q58CZ9", "url": "https://alphafold.ebi.ac.uk/entry/Q58CZ9", "database": "AlphaFoldDB", "categories": [] 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"categories": [ "Protein Classification" ] }, { "id": "IPR011715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533481", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533481", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58CZ9", "url": "https://www.orthodb.org/?gene=Q58CZ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45744", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45744", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45744:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45744:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00155", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00155", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07706", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07706", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8963684", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8963684", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029762", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "15093", "url": "https://www.rhea-db.org/rhea/15093", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MLP1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLP1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLP1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP71", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP71-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJB0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJB0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NJE3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NJE3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJE3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CZ9", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CZ9-1", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQDHGSLPSVLDVHVNVAGRSSVLGKVKSRKARWSVRPSDMSNKTFNPIRAIVDNMKVKPNPNKTMIALSIGDPTVFGNLPTDPEVTQAMKDALDSGKFNGYVPSIGYLSSREEVASYYHCPEAPLEAKDVILTSGCSQAIELCLAVLANPGQNILVPRPGFSLYRTLAESMGIEVKLYNLLPEKNWEIDLKQLESLIDEKTVCLIVNNPSNPCGSVFSRRHLQKILAVAARQCVPILADEIYGDMVFSDSKFEPLATLSSKVPILSCGGLAKRWLVPGWRMGWILIHDRRDIFGNEIRDGLTKLSQRILGPCTLVQGALKSILCRTPRVFYHNTLSFLKSNADLCYGALAAIPGLRPIHPSGAMYLMVGIEMEHFPEFENDVEFTEQLVAEQSVHCLPATCFEYPNFFRVVITVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK", "length": 447, "header": "sp|Q58CZ9-1|ATTY_BOVIN Isoform 1 of Tyrosine aminotransferase OS=Bos taurus OX=9913 GN=TAT PE=2 SV=1 CANONICAL=Q58CZ9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MLP1-1", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9/entry#A0A3Q1MLP1-1", "sequence": { "sequence": "MQDHGSLPSVLDVHVNVAGRSSVLGKVKSRKARWSVRPSDMSNKTFNPIRAIVDNMKVKPNPNKTMIALSIGELSTLNQEAAFSFCSFLSGYLSSREEVASYYHCPEAPLEAKDVILTSGCSQAIELCLAVLANPGQNILVPRPGFSLYRTLAESMGIEVKLYNLLPEKNWEIDLKQLESLIDEKTVCLIVNNPSNPCGSVFSRRHLQKILAVAARQCVPILADEIYGDMVFSDSKFEPLATLSSKVPILSCGGLAKRWLVPGWRMGWILIHDRRDIFGNEIRDGLTKLSQRILGPCTLVQGALKSILCRTPRVFYHNTLSFLKSNADLCYGALAAIPGLRPIHPSGAMYLMVGIEMEHFPEFENDVEFTEQLVAEQSVHCLPATCFEYPNFFRVVITVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK", "length": 431, "header": "tr|A0A3Q1MLP1-1|ATTY_BOVIN Computationally mapped isoform of Tyrosine aminotransferase OS=Bos taurus OX=9913 GN=TAT PE=2 SV=2 CANONICAL=Q58CZ9-1" }, "locus": { "chromosome": "18", "start_pos": 39487916, "end_pos": 39480209, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079688.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079688.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070239.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070239.2" } ] } }, { "isoform_ac": "A0A3Q1MP71-1", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9/entry#A0A3Q1MP71-1", "sequence": { "sequence": "MKGNEEDGRIREIKGIRGCIRIHHHYHLSKNLGNFLVWLLGGCFSFTGKMQDHGSLPSVLDVHVNVAGRSSVLGKVKSRKARWSVRPSDMSNKTFNPIRAIVDNMKVKPNPNKTMIALSIGDPTVFGNLPTDPEVTQAMKDALDSGKFNGYVPSIGYLSSREEVASYYHCPEAPLEAKDVILTSGCSQAIELCLAVLANPGQNILVPRPGFSLYRTLAESMGIEVKLYNLLPEKNWEIDLKQLESLIDEKTVCLIVNNPSNPCGSVFSRRHLQKILAVAARQCVPILADEIYGDMVFSDSKFEPLATLSSKVPILSCGGLAKRWLVPGWRMGWILIHDRRDIFGNEIRDGLTKLSQRILGPCTLVQGALKSILCRTPRVFYHNTLSFLKSNADLCYGALAAIPGLRPIHPSGAMYLMVGIEMEHFPEFENDVEFTEQLVAEQSVHCLPATCFEYPNFFRVVITVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK", "length": 496, "header": "tr|A0A3Q1MP71-1|ATTY_BOVIN Computationally mapped isoform of Tyrosine aminotransferase OS=Bos taurus OX=9913 GN=TAT PE=2 SV=2 CANONICAL=Q58CZ9-1" }, "locus": { "chromosome": "18", "start_pos": 39487916, "end_pos": 39478448, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075689.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075689.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073680.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073680.2" } ] } }, { "isoform_ac": "A0AAA9TG21-1", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9/entry#A0AAA9TG21-1", "sequence": { "sequence": "MRVSGPTPICGTISGIRGCIRIHHHYHLSKNLGNFLVWLLGGCFSFTGKMQDHGSLPSVLDVHVNVAGRSSVLGKVKSRKARWSVRPSDMSNKTFNPIRAIVDNMKVKPNPNKTMIALSIGDPTVFGNLPTDPEVTQAMKDALDSGKFNGYVPSIGYLSSREEVASYYHCPEAPLEAKDVILTSGCSQAIELCLAVLANPGQNILVPRPGFSLYRTLAESMGIEVKLYNLLPEKNWEIDLKQLESLIDEKTVCLIVNNPSNPCGSVFSRRHLQKILAVAARQCVPILADEIYGDMVFSDSKFEPLATLSSKVPILSCGGLAKRWLVPGWRMGWILIHDRRDIFGNEIRDGLTKLSQRILGPCTLVQGALKSILCRTPRVFYHNTLSFLKSNADLCYGALAAIPGLRPIHPSGAMYLMVGIEMEHFPEFENDVEFTEQLVAEQSVHCLPATCFEYPNFFRVVITVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK", "length": 496, "header": "tr|A0AAA9TG21-1|ATTY_BOVIN Computationally mapped isoform of Tyrosine aminotransferase OS=Bos taurus OX=9913 GN=TAT PE=2 SV=2 CANONICAL=Q58CZ9-1" }, "locus": { "chromosome": "18", "start_pos": 39487916, "end_pos": 39479435, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104784.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104784.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095977.2", "url": "https://www.ensembl.org/id/ENSBTAP00000095977.2" } ] } }, { "isoform_ac": "A0AAF6YJB0-1", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9/entry#A0AAF6YJB0-1", "sequence": { "sequence": "MDPYVIQMQDHGSLPSVLDVHVNVAGRSSVLGKVKSRKARWSVRPSDMSNKTFNPIRAIVDNMKVKPNPNKTMIALSIGDPTVFGNLPTDPEVTQAMKDALDSGKFNGYVPSIGYLSSREEVASYYHCPEAPLEAKDVILTSGCSQAIELCLAVLANPGQNILVPRPGFSLYRTLAESMGIEVKLYNLLPEKNWEIDLKQLESLIDEKTVCLIVNNPSNPCGSVFSRRHLQKILAVAARQCVPILADEIYGDMVFSDSKFEPLATLSSKVPILSCGGLAKRWLVPGWRMGWILIHDRRDIFGNEIRDGLTKLSQRILGPCTLVQGALKSILCRTPRVFYHNTLSFLKSNADLCYGALAAIPGLRPIHPSGAMYLMVGIEMEHFPEFENDVEFTEQLVAEQSVHCLPATESHLKGP", "length": 415, "header": "tr|A0AAF6YJB0-1|ATTY_BOVIN Computationally mapped isoform of Tyrosine aminotransferase OS=Bos taurus OX=9913 GN=TAT PE=2 SV=2 CANONICAL=Q58CZ9-1" }, "locus": { "chromosome": "18", "start_pos": 39493538, "end_pos": 39480188, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002866.5", "url": "https://www.ensembl.org/id/ENSBTAT00000002866.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002866.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002866.5" } ] } }, { "isoform_ac": "A0ABI0NJE3-1", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9/entry#A0ABI0NJE3-1", "sequence": { "sequence": "MRVSGPTPICGTISGIRGCIRIHHHYHLSKNLGNFLVWLLGGCFSFTGKSLLVMDPYVIQMQDHGSLPSVLDVHVNVAGRSSVLGKVKSRKARWSVRPSDMSNKTFNPIRAIVDNMKVKPNPNKTMIALSIGDPTVFGNLPTDPEVTQAMKDALDSGKFNGYVPSIGYLSSREEVASYYHCPEAPLEAKDVILTSGCSQAIELCLAVLANPGQNILVPRPGFSLYRTLAESMGIEVKLYNLLPEKNWEIDLKQLESLIDEKTVCLIVNNPSNPCGSVFSRRHLQKILAVAARQCVPILADEIYGDMVFSDSKFEPLATLSSKVPILSCGGLAKRWLVPGWRMGWILIHDRRDIFGNEIRDGLTKLSQRILGPCTLVQGALKSILCRTPRVFYHNTLSFLKSNADLCYGALAAIPGLRPIHPSGAMYLMVGIEMEHFPEFENDVEFTEQLVAEQSVHCLPATCFEYPNFFRVVITVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK", "length": 507, "header": "tr|A0ABI0NJE3-1|A0ABI0NJE3_BOVIN Computationally mapped isoform of Tyrosine aminotransferase OS=Bos taurus OX=9913 GN=TAT PE=3 SV=1 CANONICAL=Q58CZ9-1" }, "locus": { "chromosome": "18", "start_pos": 39487916, "end_pos": 39479435, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000137257.1", "url": "https://www.ensembl.org/id/ENSBTAT00000137257.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104235.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104235.1" } ] } }, { "isoform_ac": "Q58CZ9-1", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9/entry#Q58CZ9-1", "sequence": { "sequence": "MQDHGSLPSVLDVHVNVAGRSSVLGKVKSRKARWSVRPSDMSNKTFNPIRAIVDNMKVKPNPNKTMIALSIGDPTVFGNLPTDPEVTQAMKDALDSGKFNGYVPSIGYLSSREEVASYYHCPEAPLEAKDVILTSGCSQAIELCLAVLANPGQNILVPRPGFSLYRTLAESMGIEVKLYNLLPEKNWEIDLKQLESLIDEKTVCLIVNNPSNPCGSVFSRRHLQKILAVAARQCVPILADEIYGDMVFSDSKFEPLATLSSKVPILSCGGLAKRWLVPGWRMGWILIHDRRDIFGNEIRDGLTKLSQRILGPCTLVQGALKSILCRTPRVFYHNTLSFLKSNADLCYGALAAIPGLRPIHPSGAMYLMVGIEMEHFPEFENDVEFTEQLVAEQSVHCLPATCFEYPNFFRVVITVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK", "length": 447, "header": "sp|Q58CZ9-1|ATTY_BOVIN Isoform 1 of Tyrosine aminotransferase OS=Bos taurus OX=9913 GN=TAT PE=2 SV=1 CANONICAL=Q58CZ9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 441, "end_pos": 441, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ9", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9" } ], "site_lbl": "Ser441" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ9", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:533481", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533481", "resource": "KEGG Pathway" }, { "id": "R-BTA-8963684", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8963684", "resource": "Reactome", "description": "Tyrosine catabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ9", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "glutamate metabolic process", "id": "GO:0006536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006536", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ9", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9" } ], "pmid": "" }, { "name": "amino acid metabolic process", "id": "GO:0006520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006520", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ9", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9" } ], "pmid": "" }, { "name": "L-phenylalanine catabolic process", "id": "GO:0006559", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006559", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ9", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9" } ], "pmid": "" }, { "name": "L-tyrosine catabolic process", "id": "GO:0006572", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006572", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ9", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ9", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9" } ], "pmid": "" }, { "name": "amino acid binding", "id": "GO:0016597", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016597", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ9", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9" } ], "pmid": "" }, { "name": "L-tyrosine-2-oxoglutarate transaminase activity", "id": "GO:0004838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004838", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ9", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15093", "name": "", "equation": "L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q58CZ9-1" ], "evidence": [ { "id": "15093", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15093" } ] }, { "id": "R-BTA-517444", "name": "TAT aminates HPP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q58CZ9-1" ], "evidence": [ { "id": "R-BTA-517444", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-517444" } ] }, { "id": "R-BTA-71155", "name": "TAT deaminates tyrosine", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-29406" ], "output_participant_list": [ "R-ALL-31365" ], "enzyme_list": [ "Q58CZ9-1" ], "evidence": [ { "id": "R-BTA-71155", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71155" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-29406", "participant_name": "2OG [cytosol]", "crossref": [ { "id": "16810", "database": "ChEBI", "url": "" }, { "id": "2-KETOGLUTARATE", "database": "AraCyc", "url": "" }, { "id": "C00026", "database": "KEGG Gene", "url": "" }, { "id": "164533", "database": "PubChem Compound", "url": "" }, { "id": "C00000769", "database": "KNApSAcK", "url": "" }, { "id": "328-50-7", "database": "CAS", "url": "" }, { "id": "ZINC000001532519", "database": "ZINC", "url": "" }, { "id": "C00026", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-31365", "participant_name": "HPP [cytosol]", "crossref": [ { "id": "6971070", "database": "PubChem Compound", "url": "" }, { "id": "36242", "database": "ChEBI", "url": "" }, { "id": "C01179", "database": "KEGG Gene", "url": "" }, { "id": "C01179", "database": "COMPOUND", "url": "" }, { "id": "P-HYDROXY-PHENYLPYRUVATE", "database": "AraCyc", "url": "" }, { "id": "156-39-8", "database": "CAS", "url": "" }, { "id": "ZINC000000895711", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q58CZ9", "gene_name": "TAT", "activity": [ { "ec_number": "2.6.1.5", "activity": "L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate.", "evidence": [ { "id": "Q58CZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9" } ] }, { "ec_number": "2.6.1.5", "activity": "", "evidence": [ { "id": "Q58CZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CZ9" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CZ9-F1", "pdb_chain": "global", 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"isoform_ac": "A0AAF6YUH2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9S2/entry#A0AAF6YUH2-1", "sequence": { "sequence": "MEQYAANSNSSAEQIVVQAGQIQQQQGGVTAVQLQTEAQVASASGQQVQTLQVVQGQPLMVQVSGGQLITSTGQPIMVQAVPGGQGQTIMQVPVSGTQGLQQIQLVPPGQIQIQGGQAVQVQGQQGQTQQIIIQQPQTAVTAGQTQTQQQIAVQGQQVAQTAEGQTIVYQPVNADGTILQQGMITIPAASLAGAQIVQTGANTNTTSSGQGTVTVTLPVAGNVVNSGGMVMMVPGAGSVPAIQRIPLPGAEMLEEEPLYVNAKQYHRILKRRQARAKLEAEGKIPKERRKYLHESRHRHAMARKRGEGGRFFSPKEKDSPHMQDPNQADEEAMTQIIRVS", "length": 340, "header": "tr|A0AAF6YUH2-1|NFYA_BOVIN Computationally mapped isoform of Nuclear transcription factor Y subunit alpha OS=Bos taurus OX=9913 GN=NFYA PE=2 SV=1 CANONICAL=Q5E9S2-1" }, "locus": { "chromosome": "23", "start_pos": 15022325, "end_pos": 15006107, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013080.8", "url": "https://www.ensembl.org/id/ENSBTAT00000013080.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013080.6", "url": "https://www.ensembl.org/id/ENSBTAP00000013080.6" } ] } }, { "isoform_ac": "Q5E9S2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9S2/entry#Q5E9S2-1", "sequence": { "sequence": "MEQYAANSNSSAEQIVVQAGQIQQQQQGGVTAVQLQTEAQVASASGQQVQTLQVVQGQPLMVQVSGGQLITSTGQPIMVQAVPGGQGQTIMQVPVSGTQGLQQIQLVPPGQIQIQGGQAVQVQGQQGQTQQIIIQQPQTAVTAGQTQTQQQIAVQGQQVAQTAEGQTIVYQPVNADGTILQQGMITIPAASLAGAQIVQTGANTNTTSSGQGTVTVTLPVAGNVVNSGGMVMMVPGAGSVPAIQRIPLPGAEMLEEEPLYVNAKQYHRILKRRQARAKLEAEGKIPKERRKYLHESRHRHAMARKRGEGGRFFSPKEKDSPHMQDPNQADEEAMTQIIRVS", "length": 341, "header": "sp|Q5E9S2-1|NFYA_BOVIN Isoform 1 of Nuclear transcription factor Y subunit alpha OS=Bos taurus OX=9913 GN=NFYA PE=2 SV=1 CANONICAL=Q5E9S2-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 142, "start_aa": "Thr", "end_pos": 142, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr142", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 320, "end_pos": 320, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S2", "url": "https://www.uniprot.org/uniprotkb/Q5E9S2" } ], "site_lbl": "Ser320" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S2", "url": "https://www.uniprot.org/uniprotkb/Q5E9S2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "Interaction of C/EBP-beta and NF-Y factors constrains activity levels of the nutritionally controlled promoter IA expressing the acetyl-CoA carboxylase-alpha gene in cattle.", "journal": "BMC molecular biology", "date": "2012-06-27", "authors": "Shi Xuanming, Metges Cornelia C, Seyfert Hans-Martin", "evidence": [ { "database": "RefSeq", "id": "NP_001014956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014956" } ], "reference": [ { "type": "PubMed", "id": "22738246", "url": "https://glygen.org/publication/PubMed/22738246" } ] } ], "pathway": [ { "id": "bta:539584", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539584", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LNX7-1", "protein_name": "Nuclear transcription factor Y subunit", "gene_name": "Nfya", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEQYTTNSNSSTEQIVVQAGQIQQQQGGVTAVQLQTEAQVASASGQQVQTLQVVQGQPLMVQVSGGQLITSTGQPIMVQAVPGGQGQTIMQVPVSGTQGLQQIQLVPPGQIQIQGGQAVQVQGQQGQTQQIIIQQPQTAVTAGQTQTQQQIAVQGQQVAQTAEGQTIVYQPVNADGTILQQVTVPVSGMITIPAASLAGAQIVQTGANTNTTSSGQGTVTVTLPVAGNVVNSGGMVMMVPGAGSVPAIQRIPLPGAEMLEEEPLYVNAKQYHRILKRRQARAKLEAEGKIPKERRKYLHESRHRHAMARKRGEGGRFFSPKEKDGPHIQDPNQADEEAMTQIIRVS", "length": 346 }, "evidence": [ { "id": "Q5E9S2", "url": "https://omabrowser.org/oma/group/Q5E9S2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P18576-1", "protein_name": "Nuclear transcription factor Y subunit alpha", "gene_name": "Nfya", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEQYTANSNSSTEQIVVQAGQIQQQQQGGVTAVQLQTEAQVASASGQQVQTLQVVQGQPLMVQVSGGQLITSTGQPIMVQAVPGGQGQTIMQVPVSGTQGLQQIQLVPPGQIQIQGGQAVQVQGQQGQTQQIIIQQPQTAVTAGQTQTQQQIAVQGQQVAQTAEGQTIVYQPVNADGTILQQGMITIPAASLAGAQIVQTGANTNTTSSGQGTVTVTLPVAGNVVNSGGMVMMVPGAGSVPAIQRIPLPGAEMLEEEPLYVNAKQYHRILKRRQARAKLEAEGKIPKERRKYLHESRHRHAMARKRGEGGRFFSPKEKDSPHMQDPNQADEEAMTQIIRVS", "length": 341 }, "evidence": [ { "id": "Q5E9S2", "url": "https://omabrowser.org/oma/group/Q5E9S2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P23511-1", "protein_name": "Nuclear transcription factor Y subunit alpha", "gene_name": "NFYA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEQYTANSNSSTEQIVVQAGQIQQQQQGGVTAVQLQTEAQVASASGQQVQTLQVVQGQPLMVQVSGGQLITSTGQPIMVQAVPGGQGQTIMQVPVSGTQGLQQIQLVPPGQIQIQGGQAVQVQGQQGQTQQIIIQQPQTAVTAGQTQTQQQIAVQGQQVAQTAEGQTIVYQPVNADGTILQQVTVPVSGMITIPAASLAGAQIVQTGANTNTTSSGQGTVTVTLPVAGNVVNSGGMVMMVPGAGSVPAIQRIPLPGAEMLEEEPLYVNAKQYHRILKRRQARAKLEAEGKIPKERRKYLHESRHRHAMARKRGEGGRFFSPKEKDSPHMQDPNQADEEAMTQIIRVS", "length": 347 }, "evidence": [ { "id": "Q5E9S2", "url": "https://omabrowser.org/oma/group/Q5E9S2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P23708-1", "protein_name": "Nuclear transcription factor Y subunit alpha", "gene_name": "Nfya", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEQYTTNSNSSTEQIVVQAGQIQQQQGGVTAVQLQTEAQVASASGQQVQTLQVVQGQPLMVQVSGGQLITSTGQPIMVQAVPGGQGQTIMQVPVSGTQGLQQIQLVPPGQIQIQGGQAVQVQGQQGQTQQIIIQQPQTAVTAGQTQTQQQIAVQGQQVAQTAEGQTIVYQPVNADGTILQQVTVPVSGMITIPAASLAGAQIVQTGANTNTTSSGQGTVTVTLPVAGNVVNSGGMVMMVPGAGSVPAIQRIPLPGAEMLEEEPLYVNAKQYHRILKRRQARAKLEAEGKIPKERRKYLHESRHRHAMARKRGEGGRFFSPKEKDSPHMQDPNQADEEAMTQIIRVS", "length": 346 }, "evidence": [ { "id": "Q5E9S2", "url": "https://omabrowser.org/oma/group/Q5E9S2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S2", "url": "https://www.uniprot.org/uniprotkb/Q5E9S2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S2", "url": "https://www.uniprot.org/uniprotkb/Q5E9S2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S2", "url": "https://www.uniprot.org/uniprotkb/Q5E9S2" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S2", "url": "https://www.uniprot.org/uniprotkb/Q5E9S2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S2", "url": "https://www.uniprot.org/uniprotkb/Q5E9S2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S2", "url": "https://www.uniprot.org/uniprotkb/Q5E9S2" } ], "pmid": "" }, { "name": "CCAAT-binding factor complex", "id": "GO:0016602", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016602", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S2", "url": "https://www.uniprot.org/uniprotkb/Q5E9S2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S2", "url": "https://www.uniprot.org/uniprotkb/Q5E9S2" } ], "pmid": "" }, { "name": "protein-DNA complex", "id": "GO:0032993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032993", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S2", "url": "https://www.uniprot.org/uniprotkb/Q5E9S2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S2", "url": "https://www.uniprot.org/uniprotkb/Q5E9S2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S2", "url": "https://www.uniprot.org/uniprotkb/Q5E9S2" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S2", "url": "https://www.uniprot.org/uniprotkb/Q5E9S2" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S2", "url": "https://www.uniprot.org/uniprotkb/Q5E9S2" } ], "pmid": "" }, { "name": "rhythmic process", "id": "GO:0048511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048511", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S2", "url": "https://www.uniprot.org/uniprotkb/Q5E9S2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 205, "end_pos": 207, "annotation": "n_glycosylation_sequon" }, { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9S2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 341, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9S2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9S2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5E9S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9S2" }, { "id": "PRU00966", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00966" } ], "ann_type": "Nucleotide_Binding_Annotation", "uniprotkb_annotation": "NFYA/HAP2-type", "eco_id": "ECO_0000255", "start_pos": 290, "end_pos": 315, "start_aa": "Arg", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 142 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 320 ], "sequon_annotation_sites": [ { "start_pos": 205, "end_pos": 207 }, { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { 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"gene_names": [ { "name": "RABGGTA", "type": "recommended", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ] }, { "name": "RABGGTA", "type": "synonym", "evidence": [ { "id": "NP_001015614", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015614" } ] } ], "protein_names": [ { "name": "Geranylgeranyl transferase type-2 subunit alpha", "type": "recommended", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80/entry#names_and_taxonomy" } ] }, { "name": "2.5.1.60", "type": "synonym", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80/entry#names_and_taxonomy" } ] }, { "name": "Geranylgeranyl transferase type II subunit alpha", "type": "synonym", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80/entry#names_and_taxonomy" } ] }, { "name": "Rab GG transferase alpha", "type": "synonym", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80/entry#names_and_taxonomy" } ] }, { "name": "Rab GGTase alpha", "type": "synonym", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80/entry#names_and_taxonomy" } ] }, { "name": "Rab geranyl-geranyltransferase subunit alpha", "type": "synonym", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80/entry#names_and_taxonomy" } ] }, { "name": "Rab geranylgeranyltransferase alpha subunit", "type": "synonym", "evidence": [ { "id": "NP_001015614", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015614" } ] }, { "name": "Rab geranylgeranyltransferase subunit alpha", "type": "synonym", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80/entry#names_and_taxonomy" } ] }, { "name": "geranylgeranyl transferase type II subunit alpha", "type": "synonym", "evidence": [ { "id": "NP_001015614", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015614" } ] }, { "name": "geranylgeranyl transferase type-2 subunit alpha", "type": "synonym", "evidence": [ { "id": "NP_001015614", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015614" } ] }, { "name": "rab GG transferase alpha", "type": "synonym", "evidence": [ { "id": "NP_001015614", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015614" } ] }, { "name": "rab GGTase alpha", "type": "synonym", "evidence": [ { "id": "NP_001015614", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015614" } ] }, { "name": "rab geranyl-geranyltransferase subunit alpha", "type": "synonym", "evidence": [ { "id": "NP_001015614", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015614" } ] } ], "function": [ { "annotation": "Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TUL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUL1#function" }, { "database": "UniProtKB", "id": "RU367120", "url": "https://www.uniprot.org/uniprotkb/RU367120#function" }, { "database": "UniProtKB", "id": "A0AAA9TUM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUM1#function" }, { "database": "UniProtKB", "id": "A0AAF6Z5K0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5K0#function" }, { "database": "UniProtKB", "id": "F1MGN1", "url": "https://www.uniprot.org/uniprotkb/F1MGN1#function" } ] }, { "annotation": "Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TUL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUL1#function" }, { "database": "UniProtKB", "id": "ARBA00002902", "url": "https://www.uniprot.org/uniprotkb/ARBA00002902#function" }, { "database": "UniProtKB", "id": "A0AAA9TUM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUM1#function" }, { "database": "UniProtKB", "id": "A0AAF6Z5K0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5K0#function" }, { "database": "UniProtKB", "id": "F1MGN1", "url": "https://www.uniprot.org/uniprotkb/F1MGN1#function" }, { "database": "UniProtKB", "id": "Q5EA80", "url": "https://www.uniprot.org/uniprotkb/Q5EA80#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA80", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RABGGTA", "url": "https://www.uniprot.org/uniprotkb/Q5EA80", "locus": { "chromosome": "10", "start_pos": 20900213, "end_pos": 20893284, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018796", "url": "https://www.ensembl.org/id/ENSBTAG00000018796" } ] } } ], "crossref": [ { "id": "Q5EA80", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA80", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018796", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018796", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "516619", "url": "https://www.ncbi.nlm.nih.gov/gene/516619", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516619", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516619", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CAWHHRC", "url": "https://omabrowser.org/oma/group/CAWHHRC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MGN1", "url": "https://www.orthodb.org/?gene=F1MGN1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5EA80", "url": "https://www.orthodb.org/?gene=Q5EA80", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11129", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11129", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11129:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11129:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01239", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01239", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07711", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07711", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14580", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14580", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6803205", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6803205", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8873719", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8873719", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015614", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015614", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "21240", "url": "https://www.rhea-db.org/rhea/21240", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TUL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUL1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUL1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUM1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5K0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5K0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5K0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5K0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGN1", "url": "https://www.uniprot.org/uniprotkb/F1MGN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGN1-1", "url": "https://www.uniprot.org/uniprotkb/F1MGN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA80", "url": "https://www.uniprot.org/uniprotkb/Q5EA80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA80-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA80-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHGRLKVKTSEEQAEAKRLEREQKLKLYQAATQTVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQQLEVQKSPEELATLVKAELGFLESCLRVNPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEVDERNFHCWDYRRFVAAQAAVPPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRADPQDALRCLHVSRDEACLTVSFSRPLLVGSGMETLLLMVDESPLAVEWRTPEGRNRPSHIWLCDLPATSLNDQLPQHTFRVIWTAGDAQKECVLLKGRQEGWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLQYEKETLQYFQTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYAEVRVLHLGHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQANDNAIESLDGVTNLPRLQELILCNNRLQQPAVLQPLTSCPRLTLLNLQGNPLCQAEGSSEHLAELLPSVSSILT", "length": 567, "header": "sp|Q5EA80-1|PGTA_BOVIN Isoform 1 of Geranylgeranyl transferase type-2 subunit alpha OS=Bos taurus OX=9913 GN=RABGGTA PE=2 SV=1 CANONICAL=Q5EA80-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TUL1-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA80/entry#A0AAA9TUL1-1", "sequence": { "sequence": "VGSSAWEPWGGRVAATSGHGVVPITYVPQLGLGSGGSGCGQGRTCASPVRHGRLKVKTSEEQAEAKRLEREQKLKLYQAATQTVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQQLEVQKSPEELATLVKAELGFLESCLRVNPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEVDERNFHCWDYRRFVAAQAAVPPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRADPQDALRCLHVSRDEACLTVSFSRPLLVGSGMETLLLMVDESPLAVEWRTPEGRNRPSHIWLCDLPATSLNDQLPQHTFRVIWTAGDAQKECVLLKGRQEGWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLQYEKETLQYFQTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYAEVRVLHLGHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQANDNAIESLDGVTNLPRLQELILCNNRLQQPAVLQPLTSCPRLTLLNLQGNPLCQAEGSSEHLAELLPSVSSILT", "length": 616, "header": "tr|A0AAA9TUL1-1|PGTA_BOVIN Computationally mapped isoform of Geranylgeranyl transferase type-2 subunit alpha OS=Bos taurus OX=9913 GN=RABGGTA PE=2 SV=1 CANONICAL=Q5EA80-1" }, "locus": { "chromosome": "10", "start_pos": 20899677, "end_pos": 20893409, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125239.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125239.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102058.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102058.1" } ] } }, { "isoform_ac": "A0AAA9TUM1-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA80/entry#A0AAA9TUM1-1", "sequence": { "sequence": "HGRLKVKTSEEQAEAKRLEREQKLKLYQAATQTVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQQLEVQKSPEELATLVKAELGFLESCLRVNPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEVDERNFHCWDYRRFVAAQAAVPPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRADPQDALRCLHVSRDEACLTVSFSRPLLVGSGMETLLLMVDESPLAVEWRTPEGRNRPSHIWLCDLPATSLNDQLPQHTFRVIWTAGDAQKECVLLKGRQEGWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLQYEKETLQYFQTLKASWAVDPMRAAYLDDLRSKFLLENSVLKMEYAEVRVLHLGHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQANDNAIESLDGVTNLPRLQELILCNNRLQQPAVLQPLTSCPRLTLLNLQGNPLCQAEGSSEHLAELLPSVSSILT", "length": 569, "header": "tr|A0AAA9TUM1-1|PGTA_BOVIN Computationally mapped isoform of Geranylgeranyl transferase type-2 subunit alpha OS=Bos taurus OX=9913 GN=RABGGTA PE=2 SV=2 CANONICAL=Q5EA80-1" }, "locus": { "chromosome": "10", "start_pos": 20899677, "end_pos": 20893935, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121976.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121976.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102068.2", "url": "https://www.ensembl.org/id/ENSBTAP00000102068.2" } ] } }, { "isoform_ac": "A0AAF6Z5K0-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA80/entry#A0AAF6Z5K0-1", "sequence": { "sequence": "MRQAGELDESVLELTSQILGANPDFATLWNCRREVLQQLEVQKSPEELATLVKAELGFLESCLRVNPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEVDERNFHCWDYRRFVAAQAAVPPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRADPQDALRCLHVSRDEACLTVSFSRPLLVGSGMETLLLMVDESPLAVEWRTPEGRNRPSHIWLCDLPATSLNDQLPQHTFRVIWTAGDAQKECVLLKGRQEGWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLQYEKETLQYFQTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYAEVRVLHLGHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQANDNAIESLDGVTNLPRLQELILCNNRLQQPAVLQPLTSCPRLTLLNLQGNPLCQAEGSSEHLAELLPSVSSILT", "length": 530, "header": "tr|A0AAF6Z5K0-1|PGTA_BOVIN Computationally mapped isoform of Geranylgeranyl transferase type-2 subunit alpha OS=Bos taurus OX=9913 GN=RABGGTA PE=2 SV=1 CANONICAL=Q5EA80-1" }, "locus": { "chromosome": "10", "start_pos": 20899677, "end_pos": 20893762, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025020.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025020.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025020.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025020.5" } ] } }, { "isoform_ac": "F1MGN1-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA80/entry#F1MGN1-1", "sequence": { "sequence": "MPLPLSGVKTSEEQAEAKRLEREQKLKLYQAATQTVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQQLEMALALAELGFLESCLRVNPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEVDERNFHCWDYRRFVAAQAAVPPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRADPQDALRCLHVSRDEACLTVSFSRPLLVGSGMETLLLMVDESPLAVEWRTPEGRNRPSHIWLCDLPATSLNDQLPQHTFRVIWTAGDAQKECVLLKGRQEGWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLQYEKETLQYFQTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYAEVRVLHLGHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQANDNAIESLDGVTNLPRLQELILCNNRLQQPAVLQPLTSCPRLTLLNLQGNPLCQAEGSSEHLAELLPSVSSILT", "length": 560, "header": "tr|F1MGN1-1|PGTA_BOVIN Computationally mapped isoform of Geranylgeranyl transferase type-2 subunit alpha OS=Bos taurus OX=9913 GN=RABGGTA PE=2 SV=2 CANONICAL=Q5EA80-1" }, "locus": { "chromosome": "10", "start_pos": 20899677, "end_pos": 20893804, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036474.5", "url": "https://www.ensembl.org/id/ENSBTAT00000036474.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036332.4", "url": "https://www.ensembl.org/id/ENSBTAP00000036332.4" } ] } }, { "isoform_ac": "Q5EA80-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA80/entry#Q5EA80-1", "sequence": { "sequence": "MHGRLKVKTSEEQAEAKRLEREQKLKLYQAATQTVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQQLEVQKSPEELATLVKAELGFLESCLRVNPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEVDERNFHCWDYRRFVAAQAAVPPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRADPQDALRCLHVSRDEACLTVSFSRPLLVGSGMETLLLMVDESPLAVEWRTPEGRNRPSHIWLCDLPATSLNDQLPQHTFRVIWTAGDAQKECVLLKGRQEGWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLQYEKETLQYFQTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYAEVRVLHLGHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQANDNAIESLDGVTNLPRLQELILCNNRLQQPAVLQPLTSCPRLTLLNLQGNPLCQAEGSSEHLAELLPSVSSILT", "length": 567, "header": "sp|Q5EA80-1|PGTA_BOVIN Isoform 1 of Geranylgeranyl transferase type-2 subunit alpha OS=Bos taurus OX=9913 GN=RABGGTA PE=2 SV=1 CANONICAL=Q5EA80-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 98, "end_pos": 98, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA80", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ], "site_lbl": "Ser98" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA80", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:516619", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516619", "resource": "KEGG Pathway" }, { "id": "R-BTA-6803205", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6803205", "resource": "Reactome", "description": "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" }, { "id": "R-BTA-8873719", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8873719", "resource": "Reactome", "description": "RAB geranylgeranylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A5A779-1", "protein_name": "Geranylgeranyl transferase type-2 subunit alpha", "gene_name": "RABGGTA", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MHGRLKVKTSEEQAEAKRLEREQKLKLYQTATQTVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQRLEVQKSPEELAALVKAELGFLESCLRVNPKSYGTWHHRCWLLGRLPEPNWARELELCARFLEVDERNFHCWDYRRFVASQAAVPPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRADPQDALRCLHVSRDEACLTVSFSRPLLVGPSTETLLLMVNESPLSVEWRTPDGRNRPSHVWLCDLPAASLNDHLPQHTFRVIWTAGNAQKECVLLKGRQEGWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFQTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYADVRVLHLGHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQANDNAIESLDGVTNLPRLQELSLCNNRLQQPAVLQPLASCPRLVLLNLQDNPLCQAVGISEHLAELLPSVSSILT", "length": 567 }, "evidence": [ { "id": "Q5EA80", "url": "https://omabrowser.org/oma/group/Q5EA80/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HDD1-1", "protein_name": "Geranylgeranyl transferase type-2 subunit alpha", "gene_name": "Rabggta", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQQLETQKSPEELDALVKAELGFLESCLRVNPKSYGTWHHRCWLLGRLPEPNWARELELCARFLEVDERNFHCWDYRRFVAAQAAVAPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPENVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRAEPQDVLRCLHVSRDEACLSVCFSRPLTVSSRMGTLLLMVDEAPLSVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTASDAQKECVLFKGRQECWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFHTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYAEVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALGALRCLEVLQANDNALESLDGVANLPRLQELLLCNNRLQQSAALQPLASCPKLVLLDLQGNSLCQEGGILERLTEMLPSVSSILT", "length": 567 }, "evidence": [ { "id": "Q5EA80", "url": "https://omabrowser.org/oma/group/Q5EA80/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q08602-1", "protein_name": "Geranylgeranyl transferase type-2 subunit alpha", "gene_name": "Rabggta", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQHLETEKSPEESAALVKAELGFLESCLRVNPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEADERNFHCWDYRRFVAAQAAVAPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPENVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRAEPHDVLCCVHVSREEACLSVCFSRPLTVGSRMGTLLLMVDEAPLSVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTGSDSQKECVLLKDRPECWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFSTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYADVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNALENVDGVANLPRLQELLLCNNRLQQSAAIQPLVSCPRLVLLNLQGNSLCQEEGIQERLAEMLPSVSSILT", "length": 567 }, "evidence": [ { "id": "Q5EA80", "url": "https://omabrowser.org/oma/group/Q5EA80/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q92696-1", "protein_name": "Geranylgeranyl transferase type-2 subunit alpha", "gene_name": "RABGGTA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRVNPKSYGTWHHRCWLLGRLPEPNWTRELELCARFLEVDERNFHCWDYRRFVATQAAVPPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRADPQDALRCLHVSRDEACLTVSFSRPLLVGSRMEILLLMVDDSPLIVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTAGDVQKECVLLKGRQEGWCRDSTTDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFQTLKAVDPMRATYLDDLRSKFLLENSVLKMEYAEVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPPALAALRCLEVLQASDNAIESLDGVTNLPRLQELLLCNNRLQQPAVLQPLASCPRLVLLNLQGNPLCQAVGILEQLAELLPSVSSVLT", "length": 567 }, "evidence": [ { "id": "Q5EA80", "url": "https://omabrowser.org/oma/group/Q5EA80/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JHK4-1", "protein_name": "Geranylgeranyl transferase type-2 subunit alpha", "gene_name": "Rabggta", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKREAGELDESVLELTSQILGANPDFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRVNPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEADERNFHCWDYRRFVAAQAAVAPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPENVLLRELELVQNAFFTDPNDQSAWFYHRWLLGRAEPHDVLCCLHVSREEACLSVCFSRPLIVGSKMGTLLLTVDEAPLSVEWRTPDGRNRPSHVWLCDLPAASLNDHLPQHTFRVIWTGSDTQKECVLLKGHQECWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLEYFSTLKAVDPMRAAYLDDLRSKFLVENSVLKMEYADVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNVLENLDGVANLPRLRELLLCNNRLQQSAALQTLASCPRLVFLNLQGNSLCQEEGIRERLAEMLPSVSSILT", "length": 567 }, "evidence": [ { "id": "Q5EA80", "url": "https://omabrowser.org/oma/group/Q5EA80/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "Rab geranylgeranyltransferase activity", "id": "GO:0004663", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004663", "evidence": [ { "database": "UniProtKB", "id": "Q5EA80", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q5EA80", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "Q5EA80", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5EA80", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ], "pmid": "" }, { "name": "Rab-protein geranylgeranyltransferase complex", "id": "GO:0005968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005968", "evidence": [ { "database": "UniProtKB", "id": "Q5EA80", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5EA80", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "Q5EA80", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ], "pmid": "" }, { "name": "protein geranylgeranylation", "id": "GO:0018344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018344", "evidence": [ { "database": "UniProtKB", "id": "Q5EA80", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ], "pmid": "" }, { "name": "prenylation", "id": "GO:0097354", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097354", "evidence": [ { "database": "UniProtKB", "id": "Q5EA80", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 174, "end_pos": 176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21240", "name": "", "equation": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5EA80-1", "A0AAF6Z5M1-1", "Q5EAD5-1", "P29702-1", "Q5E9B3-1", "A0AAA9SWU6-1", "A0AAA9S4G1-1" ], "evidence": [ { "id": "21240", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21240" } ] }, { "id": "R-BTA-6801101", "name": "RABGGTA binds RABGGTB", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9B3-1", "Q5EA80-1" ], "evidence": [ { "id": "R-BTA-6801101", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6801101" } ] }, { "id": "R-BTA-6801109", "name": "CHM binds RGGT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9B3-1", "Q5EA80-1" ], "evidence": [ { "id": "R-BTA-6801109", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6801109" } ] }, { "id": "R-BTA-8870461", "name": "RABGGTA and RABGGTB bind", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9B3-1", "Q5EA80-1" ], "evidence": [ { "id": "R-BTA-8870461", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8870461" } ] }, { "id": "R-BTA-8870465", "name": "RGGT binds the RAB-binding subunit", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9B3-1", "Q5EA80-1" ], "evidence": [ { "id": "R-BTA-8870465", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8870465" } ] }, { "id": "R-BTA-8870466", "name": "RGGT:CHM binds RABs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0IIG7-1", "Q8HZJ5-1", "A0A140T898-1", "F1MNI4-1", "Q3MHP2-1", "A0A3S5ZPA2-1", "A6QR46-1", "Q3ZC27-1", "A0AAA9TS74-1", "A0AAA9SV95-1", "A0A3Q1MGR4-1", "P10948-1", "Q2TBH7-1", "F1N2J9-1", "P10949-1", "P11023-1", "Q17R06-1", "A0A3Q1MWA3-1", "F1N7V2-1", "A4FV54-1", "F2Z4D5-1", "Q58DW6-1", "Q17QB7-1", "Q17QU4-1", "Q1RMR4-1", "Q5E9B3-1", "Q5EA80-1", "E1BJA0-1" ], "evidence": [ { "id": "R-BTA-8870466", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8870466" } ] }, { "id": "R-BTA-8870469", "name": "RGGT geranylgeranylates RAB proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-1131164" ], "output_participant_list": [], "enzyme_list": [ "Q0IIG7-1", "Q8HZJ5-1", "A0A140T898-1", "F1MNI4-1", "Q3MHP2-1", "A0A3S5ZPA2-1", "A6QR46-1", "Q3ZC27-1", "A0AAA9TS74-1", "A0AAA9SV95-1", "A0A3Q1MGR4-1", "P10948-1", "Q2TBH7-1", "F1N2J9-1", "P10949-1", "P11023-1", "Q17R06-1", "A0A3Q1MWA3-1", "F1N7V2-1", "A4FV54-1", "F2Z4D5-1", "Q58DW6-1", "Q17QB7-1", "Q17QU4-1", "Q1RMR4-1", "Q5E9B3-1", "Q5EA80-1", "E1BJA0-1" ], "evidence": [ { "id": "R-BTA-8870469", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8870469" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1131164", "participant_name": "geranylgeranyl diphosphate [cytosol]", "crossref": [ { "id": "48861", "database": "ChEBI", "url": "" }, { "id": "C00353", "database": "COMPOUND", "url": "" }, { "id": "3052", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "ZINC000012495043", "database": "ZINC", "url": "" }, { "id": "HMDB0004486", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1MWA3", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MWA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWA3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MWA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWA3" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S4G1", "gene_name": "FNTA", "activity": [ { "ec_number": "2.5.1.58", "activity": "L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] }, { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] }, { "ec_number": "2.5.1.58", "activity": "", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SWU6", "gene_name": "PGGT1B", "activity": [ { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAA9SWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "A0AAA9SWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6" } ] } ] }, { "uniprot_ac": "A0AAA9TS74", "gene_name": "RAB36", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] } ] }, { "uniprot_ac": "A0AAF6Z5M1", "gene_name": "RABGGTB", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAF6Z5M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "A0AAF6Z5M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1" } ] } ] }, { "uniprot_ac": "A4FV54", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] } ] }, { "uniprot_ac": "A6QR46", "gene_name": "RAB6B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] } ] }, { "uniprot_ac": "E1BJA0", "gene_name": "RAB33A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] } ] }, { "uniprot_ac": "F1MNI4", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] } ] }, { "uniprot_ac": "F1N2J9", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] } ] }, { "uniprot_ac": "F1N7V2", "gene_name": "RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "P10948", "gene_name": "RAB3B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] }, { "ec_number": "3.6.5.2", "activity": 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"A0A3Q1M430", "url": "https://www.orthodb.org/?gene=A0A3Q1M430", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q8MKH6", "url": "https://www.orthodb.org/?gene=Q8MKH6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11521", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11521", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11521:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11521:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00992", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00992", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-390522", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390522", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_776899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776899", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M430", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M430", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M430-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M430-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYL0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YPQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YPQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YPQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZPF2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZPF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZPF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZPF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8MKH6", "url": "https://www.uniprot.org/uniprotkb/Q8MKH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8MKH6-1", "url": "https://www.uniprot.org/uniprotkb/Q8MKH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8MKH6-2", "url": "https://www.uniprot.org/uniprotkb/Q8MKH6-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDAEEQEYEEEQPEEEEAAEEEEEAPEEPEPAAEPEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRAERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKLRILSERKKPLNIDHMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK", "length": 263, "header": "sp|Q8MKH6-1|TNNT1_BOVIN Isoform 1 of Troponin T, slow skeletal muscle OS=Bos taurus OX=9913 GN=TNNT1 PE=2 SV=3 CANONICAL=Q8MKH6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M430-1", "url": "https://www.uniprot.org/uniprotkb/Q8MKH6/entry#A0A3Q1M430-1", "sequence": { "sequence": "MNRRAKEASQEEVSGHSAFPFCPRSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRAERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKLRILSERKKPLNIDHMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK", "length": 244, "header": "tr|A0A3Q1M430-1|TNNT1_BOVIN Computationally mapped isoform of Troponin T, slow skeletal muscle OS=Bos taurus OX=9913 GN=TNNT1 PE=2 SV=2 CANONICAL=Q8MKH6-1" }, "locus": { "chromosome": "18", "start_pos": 62285715, "end_pos": 62279597, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080263.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080263.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068317.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068317.2" } ] } }, { "isoform_ac": "A0AAA9TYL0-1", "url": "https://www.uniprot.org/uniprotkb/Q8MKH6/entry#A0AAA9TYL0-1", "sequence": { "sequence": "MKRSSLKRRPPRRRRKKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKLRILSERKKPLNIDHMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK", "length": 159, "header": "tr|A0AAA9TYL0-1|TNNT1_BOVIN Computationally mapped isoform of Troponin T, slow skeletal muscle OS=Bos taurus OX=9913 GN=TNNT1 PE=2 SV=1 CANONICAL=Q8MKH6-1" }, "locus": { "chromosome": "18", "start_pos": 62285715, "end_pos": 62276473, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100899.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100899.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101785.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101785.1" } ] } }, { "isoform_ac": "A0AAF6YPQ5-1", "url": "https://www.uniprot.org/uniprotkb/Q8MKH6/entry#A0AAF6YPQ5-1", "sequence": { "sequence": "MLLGCGRGLGTARRLRSHQDPRMSDAEEQEYEEEQPEEEEAAEEEEEAPEEPEPAAEPEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRAERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKLRILSERKKPLNIDHMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK", "length": 285, "header": "tr|A0AAF6YPQ5-1|TNNT1_BOVIN Computationally mapped isoform of Troponin T, slow skeletal muscle OS=Bos taurus OX=9913 GN=TNNT1 PE=2 SV=1 CANONICAL=Q8MKH6-1" }, "locus": { "chromosome": "18", "start_pos": 62285715, "end_pos": 62274426, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008420.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008420.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008420.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008420.6" } ] } }, { "isoform_ac": "A0AAF6ZPF2-1", "url": "https://www.uniprot.org/uniprotkb/Q8MKH6/entry#A0AAF6ZPF2-1", "sequence": { "sequence": "MEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRAERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKLRILSERKKPLNIDHMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK", "length": 230, "header": "tr|A0AAF6ZPF2-1|TNNT1_BOVIN Computationally mapped isoform of Troponin T, slow skeletal muscle OS=Bos taurus OX=9913 GN=TNNT1 PE=2 SV=1 CANONICAL=Q8MKH6-1" }, "locus": { "chromosome": "18", "start_pos": 62285715, "end_pos": 62276448, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064903.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064903.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054828.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054828.3" } ] } }, { "isoform_ac": "Q8MKH6-1", "url": "https://www.uniprot.org/uniprotkb/Q8MKH6/entry#Q8MKH6-1", "sequence": { "sequence": "MSDAEEQEYEEEQPEEEEAAEEEEEAPEEPEPAAEPEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRAERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKLRILSERKKPLNIDHMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK", "length": 263, "header": "sp|Q8MKH6-1|TNNT1_BOVIN Isoform 1 of Troponin T, slow skeletal muscle OS=Bos taurus OX=9913 GN=TNNT1 PE=2 SV=3 CANONICAL=Q8MKH6-1" }, "locus": {} }, { "isoform_ac": "Q8MKH6-2", "url": "https://www.uniprot.org/uniprotkb/Q8MKH6/entry#Q8MKH6-2", "sequence": { "sequence": "MSDAEEQEYEEEQPEEEEAAEEEEEEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRAERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKLRILSERKKPLNIDHMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK", "length": 252, "header": "sp|Q8MKH6-2|TNNT1_BOVIN Isoform 2 of Troponin T, slow skeletal muscle OS=Bos taurus OX=9913 GN=TNNT1 PE=2 SV=3 CANONICAL=Q8MKH6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 2, "end_pos": 2, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CK2", "evidence": [ { "database": "UniProtKB", "id": "Q8MKH6", "url": "https://www.uniprot.org/uniprotkb/Q8MKH6" } ], "site_lbl": "Ser2" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Amino acid sequences of multiple fast and slow troponin T isoforms expressed in adult bovine skeletal muscles.", "journal": "J. Anim. Sci.", "date": "2003", "authors": "Muroya S, Nakajima I, Chikuni K", "evidence": [ { "database": "UniProtKB", "id": "Q8MKH6", "url": "https://www.uniprot.org/uniprotkb/Q8MKH6" } ], "reference": [ { "type": "PubMed", "id": "12772845", "url": "https://glygen.org/publication/PubMed/12772845" } ] } ], "pathway": [ { "id": "bta:282095", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282095", "resource": "KEGG Pathway" }, { "id": "R-BTA-390522", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390522", "resource": "Reactome", "description": "Striated Muscle Contraction" } ], "orthologs": [ { "uniprot_canonical_ac": "O88346-1", "protein_name": "Troponin T, slow skeletal muscle", "gene_name": "Tnnt1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDTEEQEYEEEQAEDEEAVEEEEAPEEPEPVAEREEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELIALKDRIERRRAERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKLRILSERKKPLNIDYMGEDQLREKAQELSEWIHQLESEKFDLMEKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK", "length": 262 }, "evidence": [ { "id": "Q8MKH6", "url": "https://omabrowser.org/oma/group/Q8MKH6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P13805-1", "protein_name": "Troponin T, slow skeletal muscle", "gene_name": "TNNT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLRARSAWLPPSQPSCPAREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK", "length": 278 }, "evidence": [ { "id": "Q8MKH6", "url": "https://omabrowser.org/oma/group/Q8MKH6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q75ZZ6-1", "protein_name": "Troponin T, slow skeletal muscle", "gene_name": "TNNT1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSDAEEQEYEEEQPEEEEAAEEEEAPEEPEPVAEREEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRAERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKQRILSERKKPLNIDHMGEDQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK", "length": 262 }, "evidence": [ { "id": "Q8MKH6", "url": "https://omabrowser.org/oma/group/Q8MKH6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q7TNB2-1", "protein_name": "Troponin T, slow skeletal muscle", "gene_name": "Tnnt1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSDTEEQEYEEEQAEDEEAVEEEAPEEPEPVAEREEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELIALKDRIERRRAERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKLRILSERKKPLNIDYMGEDQLREKAQELSEWIHQLESEKFDLMEKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK", "length": 261 }, "evidence": [ { "id": "Q8MKH6", "url": "https://omabrowser.org/oma/group/Q8MKH6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "troponin T binding", "id": "GO:0031014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031014", "evidence": [ { "database": "UniProtKB", "id": "Q8MKH6", "url": "https://www.uniprot.org/uniprotkb/Q8MKH6" } ], "pmid": "" }, { "name": "tropomyosin binding", "id": "GO:0005523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005523", "evidence": [ { "database": "UniProtKB", "id": "Q8MKH6", "url": "https://www.uniprot.org/uniprotkb/Q8MKH6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "sarcomere organization", "id": "GO:0045214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045214", "evidence": [ { "database": "UniProtKB", "id": "Q8MKH6", "url": "https://www.uniprot.org/uniprotkb/Q8MKH6" } ], "pmid": "" }, { "name": "regulation of muscle contraction", "id": "GO:0006937", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006937", "evidence": [ { "database": "UniProtKB", "id": "Q8MKH6", "url": "https://www.uniprot.org/uniprotkb/Q8MKH6" } ], "pmid": "" }, { "name": "slow-twitch skeletal muscle fiber contraction", "id": "GO:0031444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031444", "evidence": [ { "database": "UniProtKB", "id": "Q8MKH6", "url": "https://www.uniprot.org/uniprotkb/Q8MKH6" } ], "pmid": "" }, { "name": "skeletal muscle contraction", "id": "GO:0003009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003009", "evidence": [ { "database": "UniProtKB", "id": "Q8MKH6", "url": "https://www.uniprot.org/uniprotkb/Q8MKH6" } ], "pmid": "" }, { "name": "negative regulation of muscle contraction", "id": "GO:0045932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045932", "evidence": [ { "database": "UniProtKB", "id": "Q8MKH6", "url": "https://www.uniprot.org/uniprotkb/Q8MKH6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "troponin complex", "id": "GO:0005861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005861", "evidence": [ { "database": "UniProtKB", "id": "Q8MKH6", "url": "https://www.uniprot.org/uniprotkb/Q8MKH6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q8MKH6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 263, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q8MKH6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q8MKH6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 2 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9U9-1", "uniprot_ac": "Q5E9U9", "uniprot_id": "NPRL2_BOVIN", "mass": { "chemical_mass": 43636.0, "monoisotopic_mass": 43636.0 }, "refseq": {}, "gene_names": [ { "name": "NPRL2", "type": "recommended", "evidence": [ { "id": "Q5E9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9" } ] }, { "name": "TMEM115", "type": "recommended", "evidence": [ { "id": "Q5E9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9" } ] } ], "protein_names": [ { "name": "GATOR1 complex protein NPRL2", "type": "recommended", "evidence": [ { "id": "Q5E9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9/entry#names_and_taxonomy" } ] }, { "name": "NPR2-like protein", "type": "synonym", "evidence": [ { "id": "Q5E9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9/entry#names_and_taxonomy" } ] }, { "name": "Nitrogen permease regulator 2-like protein", "type": "synonym", "evidence": [ { "id": "Q5E9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalytic component of the GATOR1 complex, a multiprotein complex that functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway. In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. In the presence of abundant amino acids, the GATOR1 complex is ubiquitinated and inhibited by GATOR2. Within the GATOR1 complex, NPRL2 constitutes the catalytic subunit that mediates the GTPase activator activity and under methionine-sufficient conditions, the GTPase activator activity is inhibited by PRMT1 through methylation and consequently inducing timely mTORC1 activation.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U9", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9#function" }, { "database": "UniProtKB", "id": "Q8WTW4", "url": "https://www.uniprot.org/uniprotkb/Q8WTW4#function" } ] }, { "annotation": "May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.", "evidence": [ { "database": "UniProtKB", "id": "A4FUB8", "url": "https://www.uniprot.org/uniprotkb/A4FUB8#function" }, { "database": "UniProtKB", "id": "Q12893", "url": "https://www.uniprot.org/uniprotkb/Q12893#function" } ] }, { "annotation": "Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U9", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9#function" }, { "database": "UniProtKB", "id": "Q8WTW4", "url": "https://www.uniprot.org/uniprotkb/Q8WTW4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9U9", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NPRL2", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9", "locus": { "chromosome": "22", "start_pos": 50001018, "end_pos": 49997691, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019161", "url": "https://www.ensembl.org/id/ENSBTAG00000019161" } ] } } ], "crossref": [ { "id": "Q5E9U9", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9U9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019161", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019161", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532459", "url": "https://www.ncbi.nlm.nih.gov/gene/532459", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009348", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009348", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013861", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013861", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532459", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532459", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EIHFWEV", "url": "https://omabrowser.org/oma/group/EIHFWEV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A4FUB8", "url": "https://www.orthodb.org/?gene=A4FUB8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5E9U9", "url": "https://www.orthodb.org/?gene=Q5E9U9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12991", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12991", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12991:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12991:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13377", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13377", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13377:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13377:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06218", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06218", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08551", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08551", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6807878", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DIV2", "url": "https://www.uniprot.org/uniprotkb/A0A452DIV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIV2-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIV2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A4FUB8", "url": "https://www.uniprot.org/uniprotkb/A4FUB8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A4FUB8-1", "url": "https://www.uniprot.org/uniprotkb/A4FUB8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9U9", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9U9-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSSCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVTAMEKKLIGCPVCIEHKKYSRNALLFNLGFVCDAQAKTCALEPIVKKLAGYLTTLELESSFVSTEESKQKLVPIMTILLEELNASGRCTLPIDESNTIHLKVIEQRPDPPVAQEYDVPVFTKDKEDFFNSQWDLTTQQILPYIDGFRHVQKISAEADVELNLVRIAIQNLLYYGVVTLVSILQYSNVYCPTPKVQDLVDDKSLQEACLSYVTKEGHKRASLRDVFQLYCSLSPGTTVRDLIGRHPQQLQHVDERKLIQFGLMKNLIRRLQKYPVRVSRDERSHPARLYTGCHSYDEICCKTGMSYQELDERLENDPNIIICWK", "length": 380, "header": "sp|Q5E9U9-1|NPRL2_BOVIN Isoform 1 of GATOR1 complex protein NPRL2 OS=Bos taurus OX=9913 GN=NPRL2 PE=2 SV=1 CANONICAL=Q5E9U9-1" }, "isoforms": [ { "isoform_ac": "A0A452DIV2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9/entry#A0A452DIV2-1", "sequence": { "sequence": "MGPLKHSQPRPSEVLPGIEAPATDPGPTSAMGSSCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVTAMEKKLIGCPVCIEHKKYSRNALLFNLGFVCDAQAKTCALEPIVKKLAGYLTTLELESSFVSTEESKQKLVPIMTILLEELNASGRCTLPIDESNTIHLKVIEQRPDPPVAQEYDVPVFTKDKEDFFNSQWDLTTQQILPYIDGFRHVQKISAEADVELNLVRIAIQNLLYYGVVTLVSILQYSNVYCPTPKVQDLVDDKSLQEACLSYVTKEGHKRASLRDVFQLYCSLSPGTTVRDLIGRHPQQLQHVDERKLIQFGLMKNLIRRLQKYPVRVSRDERSHPARLYTGCHSYDEICCKTGMSYQELDERLENDPNIIICWK", "length": 410, "header": "tr|A0A452DIV2-1|NPRL2_BOVIN Computationally mapped isoform of GATOR1 complex protein NPRL2 OS=Bos taurus OX=9913 GN=NPRL2 PE=2 SV=1 CANONICAL=Q5E9U9-1" }, "locus": { "chromosome": "22", "start_pos": 50000867, "end_pos": 49997818, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025503.4", "url": "https://www.ensembl.org/id/ENSBTAT00000025503.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025503.4", "url": "https://www.ensembl.org/id/ENSBTAP00000025503.4" } ] } }, { "isoform_ac": "A4FUB8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9/entry#A4FUB8-1", "sequence": { "sequence": "MQRALPGARQHLGAILSSASVVVKALCAAVLFLYLLSFAVDTGCLAVTPGYLFPPNFWIWTLATHGLMEQHVWDVAISLATVVVAGRLLEPLWGALELLIFFSVVNVSVGLLGAFAYLLTYMASFNLVYLFTVRIHGALGFLGGVLVALKQTMGDCVVLRVPQVRVSVVPMLLLGLLLLLRLATLLQSPALASYGFGLISSWVYLRFYQRHSRGRGDMADHFAFATFFPEILQPVVGLLANLVHGLLVKVKICQKTVKRYDVGAPSSITISLPGTDPQDAERRRQLALKALNERLKRVEDQSVWPSMDDDEEEAGAKVDSPMPSDKAPTLPGKGAVPESSLITFEAAPPTL", "length": 351, "header": "sp|A4FUB8-1|NPRL2_BOVIN Computationally mapped isoform of GATOR1 complex protein NPRL2 OS=Bos taurus OX=9913 GN=NPRL2 PE=2 SV=1 CANONICAL=Q5E9U9-1" }, "locus": {} }, { "isoform_ac": "Q5E9U9-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9/entry#Q5E9U9-1", "sequence": { "sequence": "MGSSCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVTAMEKKLIGCPVCIEHKKYSRNALLFNLGFVCDAQAKTCALEPIVKKLAGYLTTLELESSFVSTEESKQKLVPIMTILLEELNASGRCTLPIDESNTIHLKVIEQRPDPPVAQEYDVPVFTKDKEDFFNSQWDLTTQQILPYIDGFRHVQKISAEADVELNLVRIAIQNLLYYGVVTLVSILQYSNVYCPTPKVQDLVDDKSLQEACLSYVTKEGHKRASLRDVFQLYCSLSPGTTVRDLIGRHPQQLQHVDERKLIQFGLMKNLIRRLQKYPVRVSRDERSHPARLYTGCHSYDEICCKTGMSYQELDERLENDPNIIICWK", "length": 380, "header": "sp|Q5E9U9-1|NPRL2_BOVIN Isoform 1 of GATOR1 complex protein NPRL2 OS=Bos taurus OX=9913 GN=NPRL2 PE=2 SV=1 CANONICAL=Q5E9U9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U9", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:532459", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532459", "resource": "KEGG Pathway" }, { "id": "R-BTA-6807878", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "resource": "Reactome", "description": "COPI-mediated anterograde transport" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZE59-1", "protein_name": "Transmembrane protein 115", "gene_name": "Tmem115", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQRALPGARQHLGAILASASVVVKALCAVVLFLYLLSFAVDTGCLAVTPGYLFPPNFWIWTLATHGLMEQHVWDVAISLATVVVAGRLLEPLWGALELLIFFSVVNVSVGLLGAFAYLLTYMASFNLVYLFTIRIHGALGFLGGVLVALKQTMGDCVVLRVPQVRVSVVPMLLLALLLLLRLATLLQSPALASYGFGLLSSWVYLRFYQRHSRGRGDMADHFAFATFFPEILQPVVGLLANLVHGLLVKVKICQKTVKRYDVGAPSSITISLPGTDPQDAERRRQLALKALNERLKRVEDQSAWPSMDDDEEEAGAKTDSPLPSEQASTPPGKGTAPESTLITFEAAPLL", "length": 350 }, "evidence": [ { "id": "Q5E9U9", "url": "https://omabrowser.org/oma/group/Q5E9U9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H8B8-1", "protein_name": "Transmembrane protein 115", "gene_name": "Tmem115", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MQRALPGARQHLGAIVASASVVVKALCAVVLFLYLLSFAVDTGCLAVTPGYLFPPNFWIWTLATHGLMEQHVWDVAISLATVVVAGRLLEPLWGALELLIFFSVVNVSVGLLGAFAYLVTYMASFNLVYLFTIRIHGALGFLGGVLVALKQTMGDCVVLRVPQVRVSVVPMLLLALLLLLRLATLLQSPALASYGFGLLSSWVYLRFYQRHSRGRGDMADHFAFATFFPEILQPVVGLLANLVHGLLVKVKVCQKTVKRYDVGAPSAITISLPGTDPQDAERRRQLALKALNERLKRVEDQSVWPSMDDDEEEAGAKKDSPLPSEEASTPPGKGTTPESSLITFEAAPPKL", "length": 351 }, "evidence": [ { "id": "Q5E9U9", "url": "https://omabrowser.org/oma/group/Q5E9U9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q12239-1", "protein_name": "Transmembrane protein 115 homolog", "gene_name": "", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MQYSSRFLELNIPDSFLNINKIPDATKFITVTYICLTATLFCIRRSLYNKLVLEDPNLDYNLITSPLLQMVPSQIWRYPTSLVLSNFIDTKAWKVVVNLLNLIIGGSFIERNWNSSKEMFKFIIVLGSLTNVLIIMLTLLVSFFSNKVRLDIPLDGNYTILIGFPIIYRQLLPETTIIHLKTPQFLAKNFRFKLLPIFVMFTMTVTQIIWFHHFAQLFSIWVTFFASWSYLRFFQKLAPLNCPSLPTTNSQGGQEILVGDASDTFQLIYFFPDLIKPILRPIFNFIYNVVVVKFKVIKPFHDIDIDIGNTIAESRGAKKIMTVEERRRQLALQVLEERMVNP", "length": 342 }, "evidence": [ { "id": "Q5E9U9", "url": "https://omabrowser.org/oma/group/Q5E9U9/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q12893-1", "protein_name": "Transmembrane protein 115", "gene_name": "TMEM115", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQRALPGARQHLGAILASASVVVKALCAAVLFLYLLSFAVDTGCLAVTPGYLFPPNFWIWTLATHGLMEQHVWDVAISLTTVVVAGRLLEPLWGALELLIFFSVVNVSVGLLGAFAYLLTYMASFNLVYLFTVRIHGALGFLGGVLVALKQTMGDCVVLRVPQVRVSVMPMLLLALLLLLRLATLLQSPALASYGFGLLSSWVYLRFYQRHSRGRGDMADHFAFATFFPEILQPVVGLLANLVHSLLVKVKICQKTVKRYDVGAPSSITISLPGTDPQDAERRRQLALKALNERLKRVEDQSIWPSMDDDEEESGAKVDSPLPSDKAPTPPGKGAAPESSLITFEAAPPTL", "length": 351 }, "evidence": [ { "id": "Q5E9U9", "url": "https://omabrowser.org/oma/group/Q5E9U9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8LF05-1", "protein_name": "Rhomboid-like protein 19", "gene_name": "RBL19", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSSPGTSMFTNFTKLCKGLALVLVVGHLVVQFIPATVPYLALIPARTIPFAWNLITSGYFELSVYGVVFSTVSLLFMGKFLEPVWGSTEFLKFIFVVNFLTYLCVFVTAIALYYITRLEVYLYMPFAGFHGVLAGLLVGIKQIIPDQEILLLKIKAKWLPSIMLILSIASSFFTLDSAAYLPTLIFGTYMGWLYLRYLQRRPETKLRGDPSDDFAFSTFFPELLRPVIDPIALIFHRMLCGRSNATSEDHDYSTSGAPLPGSDSAEASRRRERGARALEERLGTERLVPARNKDELQSDGLDNV", "length": 304 }, "evidence": [ { "id": "Q5E9U9", "url": "https://omabrowser.org/oma/group/Q5E9U9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VMD2-1", "protein_name": "Transmembrane protein 115", "gene_name": "Dmel\\CG9536", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSAQLARNWPYIWQQLNALLHNTSPVITLICVVTTFGYLLSFSETAILLLSVTPGYILPNGKFWIWTAFTFCFIELHWWEVAVDVVTVGLCGKMLEPLWGQLEMFKFFALSNFGVSLLTTVYYLFYYMVTKNPTILFEVHIHGLAGYVAGICVAVRQIMPDHLIFKTRYGRLTNRNVPLTVLIMAIILWAIGLLDGTYPAMFASGSLVSWIYLRFYQHHPNGRGDSSESFTFVSFFPNVSQPFISVLVNPIYNCCLRAGVVKTPTPLRTISTASLTSVSVQMPGVDPHDIERRRQIALKALSERLKATDSSRHAQLPKSFPQQQQLQHHHHQHAPHQQQKHHSHGTGHSHSHGAGHSHSHGAGHSHGPGPAQMPQPDFLKSTGSASQLPITTSRAEPRMISTMSPIAIPMPAPPPKEGNVPGQGAESSSSGGVEATLINLDDVPTTSSMA", "length": 450 }, "evidence": [ { "id": "Q5E9U9", "url": "https://omabrowser.org/oma/group/Q5E9U9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9WUH1-1", "protein_name": "Transmembrane protein 115", "gene_name": "Tmem115", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQRALPGARQHLGAILASASVVVKALCAVVLFLYLLSFAVDTGCLAVTPGYLFPPNFWIWTLATHGLMEQHVWDVAISLATVVVAGRLLEPLWGALELLIFFSVVNVSVGLLGALAYLLTYMASFNLVYLFTIRIHGALGFLGGVLVALKQTMGDCVVLRVPQVRVSVVPMLLLALLLLLRLATLLQSPALASYGFGLLSSWVYLRFYQRHSRGRGDMADHFAFATFFPEILQPVVGLLANLVHGLLVKVKICQKTVKRYDVGAPSSITISLPGTDPQDAERRRQLALKALNERLKRVEDQSAWPSMDDDEEEAGAKTDSPLPLEEASTPPGKVTVPESSLITLETAPLL", "length": 350 }, "evidence": [ { "id": "Q5E9U9", "url": "https://omabrowser.org/oma/group/Q5E9U9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U9", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9" } ], "pmid": "" }, { "name": "Golgi cisterna membrane", "id": "GO:0032580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032580", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U9", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U9", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9" } ], "pmid": "" }, { "name": "GATOR1 complex", "id": "GO:1990130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990130", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U9", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9" } ], "pmid": "" }, { "name": "vacuolar membrane", "id": "GO:0005774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005774", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U9", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U9", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9" } ], "pmid": "" }, { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U9", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "id": "GO:0006890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006890", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U9", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9" } ], "pmid": "" }, { "name": "cellular response to amino acid starvation", "id": "GO:0034198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034198", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U9", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9" } ], "pmid": "" }, { "name": "negative regulation of TORC1 signaling", "id": "GO:1904262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904262", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U9", "url": "https://www.uniprot.org/uniprotkb/Q5E9U9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9U9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 380, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9U9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9U9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 140, "end_pos": 142 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DN7-1", "uniprot_ac": "Q58DN7", "uniprot_id": "ACSF3_BOVIN", "mass": { "chemical_mass": 64990.0, "monoisotopic_mass": 64990.0 }, "refseq": { "ac": "NP_001030240", "name": "malonate--CoA ligase ACSF3, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030240" }, "gene_names": [ { "name": "ACSF3", "type": "recommended", "evidence": [ { "id": "Q58DN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN7" } ] }, { "name": "ACSF3", "type": "synonym", "evidence": [ { "id": "NP_001030240", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030240" } ] } ], "protein_names": [ { "name": "Malonate--CoA ligase ACSF3, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q58DN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN7/entry#names_and_taxonomy" } ] }, { "name": "6.2.1.76", "type": "synonym", "evidence": [ { "id": "Q58DN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN7/entry#names_and_taxonomy" } ] }, { "name": "Acyl-CoA synthetase family member 3", "type": "synonym", "evidence": [ { "id": "Q58DN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN7/entry#names_and_taxonomy" } ] }, { "name": "acyl-CoA synthetase family member 3, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001030240", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030240" } ] }, { "name": "malonate--CoA ligase ACSF3, mitochondrial precursor", "type": "synonym", "evidence": [ { "id": "NP_001030240", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030240" } ] }, { "name": "malonate--CoA ligase ACSF3, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001030240", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030240" } ] } ], "function": [ { "annotation": "Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LS82", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS82#function" }, { "database": "UniProtKB", "id": "ARBA00055210", "url": "https://www.uniprot.org/uniprotkb/ARBA00055210#function" }, { "database": "UniProtKB", "id": "A0AAF7AGT4", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AGT4#function" }, { "database": "UniProtKB", "id": "A0AAF7AST6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AST6#function" }, { "database": "UniProtKB", "id": "Q58DN7", "url": "https://www.uniprot.org/uniprotkb/Q58DN7#function" }, { "database": "UniProtKB", "id": "Q4G176", "url": "https://www.uniprot.org/uniprotkb/Q4G176#function" }, { "database": "UniProtKB", "id": "A0A3Q1MX65", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MX65#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DN7", "url": "https://www.uniprot.org/uniprotkb/Q58DN7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACSF3", "url": "https://www.uniprot.org/uniprotkb/Q58DN7", "locus": { "chromosome": "18", "start_pos": 14248450, "end_pos": 14203769, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015968", "url": "https://www.ensembl.org/id/ENSBTAG00000015968" } ] } } ], "crossref": [ { "id": "Q58DN7", "url": "https://alphafold.ebi.ac.uk/entry/Q58DN7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015968", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015968", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05941", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05941", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509209", "url": "https://www.ncbi.nlm.nih.gov/gene/509209", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020845", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020845", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042099", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045851", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509209", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509209", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LS82", "url": "https://www.orthodb.org/?gene=A0A3Q1LS82", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MX65", "url": "https://www.orthodb.org/?gene=A0A3Q1MX65", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q58DN7", "url": "https://www.orthodb.org/?gene=Q58DN7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43201", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43201", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43201:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43201:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00501", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00501", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13193", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13193", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75876", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030240", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "32139", "url": "https://www.rhea-db.org/rhea/32139", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "33639", "url": "https://www.rhea-db.org/rhea/33639", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LS82", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS82", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LS82-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS82-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MX65", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MX65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MX65-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MX65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z216", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z216", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z216-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z216-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AGT4", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AGT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AGT4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AGT4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AST6", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AST6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7AST6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7AST6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DN7", "url": "https://www.uniprot.org/uniprotkb/Q58DN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DN7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DN7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLPYVGMALRRLAWAVASCRLAPWTRGASGPLHSAPAARSDCSAPVFIRAPAFGDRLALIDQHGRHTYKDLYLRSLRLSREICQLRACADGDLREERVSLLCSNDVSFVVAQWAAWMSGGVAVPLYRKHPRAQLEYFIQDSRSSVVLAGPEHVELLSPVAQKLGVPLLPLPPTVYHGVAEDPEEGLVLERNWRDRGAMIIYTSGTTGRPKGVLSTHDNIRAVVTGLVHKWAWTKDDVILHVLPLHHVHGVVNKLLCPLWVGATCVMLPEFSAQLVWEKFLSSEAPQINVFMAVPTIYSKLMDYYDKHFTQPHVQDFVRAVCEEKIRLMVSGSAALPLPVLEKWKGITGHTLLERYGMTEIGMALSNPLTAARLPGSVGTPLPGVEVRIVSENPQKDSSPYLIHAEGSEENTKVTPGFEEKEGELLVRGPSVFREYWDKPEETKAAFTSDGWFKTGDTVVFKDGCYWIRGRTSVDIIKSGGYKVSALEVERLLLAHPSITDVAVIGVPDMTWGQRVTAVVTLQEGHSLSHRELKEWARGVLAPYAVPSELLLVEEIPRNQMGKVNKRDLVRQLYPHEKGAPEAGSQ", "length": 586, "header": "sp|Q58DN7-1|ACSF3_BOVIN Isoform 1 of Malonate--CoA ligase ACSF3, mitochondrial OS=Bos taurus OX=9913 GN=ACSF3 PE=2 SV=1 CANONICAL=Q58DN7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LS82-1", "url": "https://www.uniprot.org/uniprotkb/Q58DN7/entry#A0A3Q1LS82-1", "sequence": { "sequence": "MPLPYVGMALRRLAWAVASCRLAPWTRGASGPLHSAPAARSDCSAPVFIRAPAFGDRLALIDQHGRHTYKDLYLRSLRLSREICQLRACADGDLREERVSLLCSNDVSFVVAQWAAWMSGGVAVPLYRKHPRAQLEYFIQDSRSSVVLAGPEHVELLSPVAQKLGVPLLPLPPTVYHGVAEDPEEGLVLERNWRDRGAMIIYTSGTTGRPKGVLSTHDNIRAVVTGLVHKWAWTKDDVILHVLPLHHVHGVVNKLLCPLWVGATCVMLPEFSAQLVWEKFLSSEAPQINVFMAVPTIYSKLMDYYDKHFTQPHVQDFVRAVCEEKIRSVSIVHLPIWKVLKITLCSLYFKMCLYVSLNTPVFPAQLPGFCSVGTPLPGVEVRIVSENPQKDSSPYLIHAEGSEENTKVTPGFEEKEGELLVRGPSVFREYWDKPEETKAAFTSDGWFKTGDTVVFKDGCYWIRGRTSVDIIKSGGYKVSALEVERLLLAHPSITDVAVIGVPDMTWGQRVTAVVTLQEGHSLSHRELKEWARGVLAPYAVPSELLLVEEIPRNQMGKVNKRDLVRQLYPHEKGAPEAGSQ", "length": 580, "header": "tr|A0A3Q1LS82-1|ACSF3_BOVIN Computationally mapped isoform of Malonate--CoA ligase ACSF3, mitochondrial OS=Bos taurus OX=9913 GN=ACSF3 PE=2 SV=1 CANONICAL=Q58DN7-1" }, "locus": { "chromosome": "18", "start_pos": 14248257, "end_pos": 14210519, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074151.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074151.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057924.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057924.1" } ] } }, { "isoform_ac": "A0A3Q1MX65-1", "url": "https://www.uniprot.org/uniprotkb/Q58DN7/entry#A0A3Q1MX65-1", "sequence": { "sequence": "MRLGAGRAVREYRGSCSGFDPARRRYYQLASAAAMPLPYVGMALRRLAWAVASCRLAPWTRGASGPLHSAPAARSDCSAPVFIRAPAFGDRLALIDQHGRHTYKDLYLRSLRLSREICQLRACADGDLREERVSLLCSNDVSFVVAQWAAWMSGGVAVPLYRKHPRAQLEYFIQDSRSSVVLAGPEHVELLSPVAQKLGVPLLPLPPTVYHGVAEDPEEGLVLERNWRDRGAMIIYTSGTTGRPKGVLSTHDNIRAVVTGLVHKWAWTKDDVILHVLPLHHVHGVVNKLLCPLWVGATCVMLPEFSAQLVWEKFLSSEAPQINVFMAVPTIYSKLMDYYDKHFTQPHVQDFVRAVCEEKIRLMVSGSAALPLPVLEKWKGITGHTLLERYGMTEIGMALSNPLTAARLPGSVGTPLPGVEVRIVSENPQKDSSPYLIHAEGSEENTKVTPGFEEKEGELLVRGPSVFREYWDKPEETKAAFTSDGWFKTGDTVVFKDGCYWIRGRTSVDIIKSGGYKVSALEVERLLLAHPSITDVAVIGVPDMTWGQRVTAVVTLQEGHSLSHRELKEWARGVLAPYAVPSELLLVEEIPRNQMGKVNKRDLVRQLYPHEKGAPEAGSQ", "length": 620, "header": "tr|A0A3Q1MX65-1|ACSF3_BOVIN Computationally mapped isoform of Malonate--CoA ligase ACSF3, mitochondrial OS=Bos taurus OX=9913 GN=ACSF3 PE=2 SV=2 CANONICAL=Q58DN7-1" }, "locus": { "chromosome": "18", "start_pos": 14248257, "end_pos": 14203968, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067054.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067054.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060268.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060268.2" } ] } }, { "isoform_ac": "A0AAF6Z216-1", "url": "https://www.uniprot.org/uniprotkb/Q58DN7/entry#A0AAF6Z216-1", "sequence": { "sequence": "MPLPYVGMALRRLAWAVASCRLAPWTRGASGPLHSAPAARSDCSAPVFIRAPAFGDRLALIDQHGRHTYKDLYLRSLRLSREICQLRACADGDLREERVSLLCSNDVSFVVAQWAAWMSGGVAVPLYRKHPRAQLEYFIQDSRSSVVLAGPEHVELLSPVAQKLGVPLLPLPPTVYHGVAEDPEEGLVLERNWRDRGAMIIYTSGTTGRPKGVLSTHDNIRAVVTGLVHKWAWTKDDVILHVLPLHHVHGVVNKLLCPLWVGATCVMLPEFSAQLVWEKFLSSEAPQINVFMAVPTIYSKLMDYYDKHFTQPHVQDFVRAVCEEKIRLMVSGSAALPLPVLEKWKGITGHTLLERYGMTEIGMALSNPLTAARLPGSVGTPLPGVEVRIVSENPQKDSSPYLIHAEGSEENTKVTPGFEEKEGELLVRGPSVFREYWDKPEETKAAFTSDGWFKTGDTVVFKDGCYWIRGRTSVDIIKSGGYKVSALEVERLLLAHPSITDVAVIGVPDMTWGQRVTAVVTLQEGHSLSHRELKEWARPLVSAEASWPHTLCPRSCCWWRRSRGTRWGRSTSETSSGSFTRMRRAPPRPGASEPASRAARMKPP", "length": 604, "header": "tr|A0AAF6Z216-1|ACSF3_BOVIN Computationally mapped isoform of Malonate--CoA ligase ACSF3, mitochondrial OS=Bos taurus OX=9913 GN=ACSF3 PE=2 SV=1 CANONICAL=Q58DN7-1" }, "locus": { "chromosome": "18", "start_pos": 14248294, "end_pos": 14210519, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021234.5", "url": "https://www.ensembl.org/id/ENSBTAT00000021234.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021234.4", "url": "https://www.ensembl.org/id/ENSBTAP00000021234.4" } ] } }, { "isoform_ac": "A0AAF7AGT4-1", "url": "https://www.uniprot.org/uniprotkb/Q58DN7/entry#A0AAF7AGT4-1", "sequence": { "sequence": "MMPCEAWYYQLASAAAMPLPYVGMALRRLAWAVASCRLAPWTRGASGPLHSAPAARSDCSAPVFIRAPAFGDRLALIDQHGRHTYKDLYLRSLRLSREICQLRACADGDLREERVSLLCSNDVSFVVAQWAAWMSGGVAVPLYRKHPRAQLEYFIQDSRSSVVLAGPEHVELLSPVAQKLGVPLLPLPPTVYHGVAEDPEEGLVLERNWRDRGAMIIYTSGTTGRPKGVLSTHDNIRAVVTGLVHKWAWTKDDVILHVLPLHHVHGVVNKLLCPLWVGATCVMLPEFSAQLVWEKFLSSEAPQINVFMAVPTIYSKLMDYYDKHFTQPHVQDFVRAVCEEKIRLMVSGSAALPLPVLEKWKGITGHTLLERYGMTEIGMALSNPLTAARLPGSVGTPLPGVEVRIVSENPQKDSSPYLIHAEGSEENTKVTPGFEEKEGELLVRGPSVFREYWDKPEETKAAFTSDGWFKTGDTVVFKDGCYWIRGRTSVDIIKSGGYKVSALEVERLLLAHPSITDVAVIGVPDMTWGQRVTAVVTLQEGHSLSHRELKEWARGVLAPYAVPSELLLVEEIPRNQMGKVNKRDLVRQLYPHEKGAPEAGSQ", "length": 602, "header": "tr|A0AAF7AGT4-1|ACSF3_BOVIN Computationally mapped isoform of Malonate--CoA ligase ACSF3, mitochondrial OS=Bos taurus OX=9913 GN=ACSF3 PE=2 SV=1 CANONICAL=Q58DN7-1" }, "locus": { "chromosome": "18", "start_pos": 14248257, "end_pos": 14208065, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085479.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085479.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068809.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068809.2" } ] } }, { "isoform_ac": "A0AAF7AST6-1", "url": "https://www.uniprot.org/uniprotkb/Q58DN7/entry#A0AAF7AST6-1", "sequence": { "sequence": "MSLPWASLRAVWSDCGPAPHTCVCPAPLRSSGSPRYYQLASAAAMPLPYVGMALRRLAWAVASCRLAPWTRGASGPLHSAPAARSDCSAPVFIRAPAFGDRLALIDQHGRHTYKDLYLRSLRLSREICQLRACADGDLREERVSLLCSNDVSFVVAQWAAWMSGGVAVPLYRKHPRAQLEYFIQDSRSSVVLAGPEHVELLSPVAQKLGVPLLPLPPTVYHGVAEDPEEGLVLERNWRDRGAMIIYTSGTTGRPKGVLSTHDNIRAVVTGLVHKWAWTKDDVILHVLPLHHVHGVVNKLLCPLWVGATCVMLPEFSAQLVWEKFLSSEAPQINVFMAVPTIYSKLMDYYDKHFTQPHVQDFVRAVCEEKIRLMVSGSAALPLPVLEKWKGITGHTLLERYGMTEIGMALSNPLTAARLPGSVGTPLPGVEVRIVSENPQKDSSPYLIHAEGSEENTKVTPGFEEKEGELLVRGPSVFREYWDKPEETKAAFTSDGWFKTGDTVVFKDGCYWIRGRTSVDIIKSGGYKVSALEVERLLLAHPSITDVAVIGVPDMTWGQRVTAVVTLQEGHSLSHRELKEWARGVLAPYAVPSELLLVEEIPRNQMGKVNKRDLVRQLYPHEKGAPEAGSQ", "length": 630, "header": "tr|A0AAF7AST6-1|ACSF3_BOVIN Computationally mapped isoform of Malonate--CoA ligase ACSF3, mitochondrial OS=Bos taurus OX=9913 GN=ACSF3 PE=2 SV=1 CANONICAL=Q58DN7-1" }, "locus": { "chromosome": "18", "start_pos": 14248257, "end_pos": 14207266, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076555.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076555.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073922.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073922.2" } ] } }, { "isoform_ac": "Q58DN7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DN7/entry#Q58DN7-1", "sequence": { "sequence": "MPLPYVGMALRRLAWAVASCRLAPWTRGASGPLHSAPAARSDCSAPVFIRAPAFGDRLALIDQHGRHTYKDLYLRSLRLSREICQLRACADGDLREERVSLLCSNDVSFVVAQWAAWMSGGVAVPLYRKHPRAQLEYFIQDSRSSVVLAGPEHVELLSPVAQKLGVPLLPLPPTVYHGVAEDPEEGLVLERNWRDRGAMIIYTSGTTGRPKGVLSTHDNIRAVVTGLVHKWAWTKDDVILHVLPLHHVHGVVNKLLCPLWVGATCVMLPEFSAQLVWEKFLSSEAPQINVFMAVPTIYSKLMDYYDKHFTQPHVQDFVRAVCEEKIRLMVSGSAALPLPVLEKWKGITGHTLLERYGMTEIGMALSNPLTAARLPGSVGTPLPGVEVRIVSENPQKDSSPYLIHAEGSEENTKVTPGFEEKEGELLVRGPSVFREYWDKPEETKAAFTSDGWFKTGDTVVFKDGCYWIRGRTSVDIIKSGGYKVSALEVERLLLAHPSITDVAVIGVPDMTWGQRVTAVVTLQEGHSLSHRELKEWARGVLAPYAVPSELLLVEEIPRNQMGKVNKRDLVRQLYPHEKGAPEAGSQ", "length": 586, "header": "sp|Q58DN7-1|ACSF3_BOVIN Isoform 1 of Malonate--CoA ligase ACSF3, mitochondrial OS=Bos taurus OX=9913 GN=ACSF3 PE=2 SV=1 CANONICAL=Q58DN7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DN7", "url": "https://www.uniprot.org/uniprotkb/Q58DN7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:509209", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509209", "resource": "KEGG Pathway" }, { "id": "R-BTA-75876", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75876", "resource": "Reactome", "description": "Synthesis of very long-chain fatty acyl-CoAs" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q58DN7", "url": "https://www.uniprot.org/uniprotkb/Q58DN7" } ], "pmid": "" }, { "name": "CoA-ligase activity", "id": "GO:0016405", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016405", "evidence": [ { "database": "UniProtKB", "id": "Q58DN7", "url": "https://www.uniprot.org/uniprotkb/Q58DN7" } ], "pmid": "" }, { "name": "malonyl-CoA synthetase activity", "id": "GO:0090409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090409", "evidence": [ { "database": "UniProtKB", "id": "Q58DN7", "url": "https://www.uniprot.org/uniprotkb/Q58DN7" } ], "pmid": "" }, { "name": "ligase activity", "id": "GO:0016874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016874", "evidence": [ { "database": "UniProtKB", "id": "Q58DN7", "url": "https://www.uniprot.org/uniprotkb/Q58DN7" } ], "pmid": "" }, { "name": "very long-chain fatty acid-CoA ligase activity", "id": "GO:0031957", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031957", "evidence": [ { "database": "UniProtKB", "id": "Q58DN7", "url": "https://www.uniprot.org/uniprotkb/Q58DN7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q58DN7", "url": "https://www.uniprot.org/uniprotkb/Q58DN7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58DN7", "url": "https://www.uniprot.org/uniprotkb/Q58DN7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "fatty acid biosynthetic process", "id": "GO:0006633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006633", "evidence": [ { "database": "UniProtKB", "id": "Q58DN7", "url": "https://www.uniprot.org/uniprotkb/Q58DN7" } ], "pmid": "" }, { "name": "malonate catabolic process", "id": "GO:0090410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090410", "evidence": [ { "database": "UniProtKB", "id": "Q58DN7", "url": "https://www.uniprot.org/uniprotkb/Q58DN7" } ], "pmid": "" }, { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "Q58DN7", "url": "https://www.uniprot.org/uniprotkb/Q58DN7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "32139", "name": "", "equation": "malonate + ATP + CoA = malonyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q58DN7-1" ], "evidence": [ { "id": "32139", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/32139" } ] }, { "id": "33639", "name": "", "equation": "tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MB67-1", "F1MIU7-1", "E1BCN4-1", "F1MQP2-1", "Q3ZKN0-1", "Q58DN7-1" ], "evidence": [ { "id": "33639", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33639" } ] }, { "id": "R-BTA-5696007", "name": "ACSF3 ligates CoA-SH to VLCFA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-29374", "R-ALL-5696008" ], "output_participant_list": [ "R-ALL-5696003" ], "enzyme_list": [ "Q58DN7-1" ], "evidence": [ { "id": "R-BTA-5696007", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696007" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-29374", "participant_name": "CoA-SH [mitochondrial matrix]", "crossref": [ { "id": "57287", "database": "ChEBI", "url": "" }, { "id": "ZINC000008551087", "database": "ZINC", "url": "" }, { "id": "C00010", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-5696003", "participant_name": "VLCFA-CoA [mitochondrial matrix]", "crossref": [ { "id": "138261", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-5696008", "participant_name": "VLCFA [mitochondrial matrix]", "crossref": [ { "id": "58950", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "E1BCN4", "gene_name": "ACSBG2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "E1BCN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCN4" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "E1BCN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCN4" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "E1BCN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCN4" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "E1BCN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCN4" } ] } ] }, { "uniprot_ac": "F1MB67", "gene_name": "SLC27A1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "F1MB67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB67" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "F1MB67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB67" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "F1MB67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB67" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "F1MB67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB67" } ] } ] }, { "uniprot_ac": "F1MIU7", "gene_name": "SLC27A3", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "F1MIU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIU7" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "F1MIU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIU7" } ] } ] }, { "uniprot_ac": "F1MQP2", "gene_name": "SLC27A2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "F1MQP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQP2" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "F1MQP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQP2" } ] } ] }, { "uniprot_ac": "Q3ZKN0", "gene_name": "SLC27A1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q3ZKN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZKN0" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q3ZKN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZKN0" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q3ZKN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZKN0" } ] } ] }, { "uniprot_ac": "Q58DN7", "gene_name": "ACSF3", "activity": [ { "ec_number": "6.2.1.76", "activity": "malonate + ATP + CoA = malonyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q58DN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN7" } ] }, { "ec_number": "6.2.1.76", "activity": "", "evidence": [ { "id": "Q58DN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN7" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DN7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 586, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DN7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DN7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.2.1.76", "ec_name": "malonate + ATP + CoA = malonyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "6.2.1.76", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.76" }, { "id": "6.2.1.76", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.2.1.76" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q7YS61-1", "uniprot_ac": "Q7YS61", "uniprot_id": "TRDMT_BOVIN", "mass": { "chemical_mass": 44570.0, "monoisotopic_mass": 44570.0 }, "refseq": { "ac": "NP_861528", "name": "tRNA (cytosine(38)-C(5))-methyltransferase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861528" }, "gene_names": [ { "name": "TRDMT1", "type": "recommended", "evidence": [ { "id": "Q7YS61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS61" } ] }, { "name": "DNMT2", "type": "synonym", "evidence": [ { "id": "NP_861528", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861528" }, { "id": "Q7YS61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS61" } ] }, { "name": "TRDMT1", "type": "synonym", "evidence": [ { "id": "NP_861528", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861528" } ] } ], "protein_names": [ { "name": "tRNA (cytosine(38)-C(5))-methyltransferase", "type": "recommended", "evidence": [ { "id": "Q7YS61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS61/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.204", "type": "synonym", "evidence": [ { "id": "Q7YS61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS61/entry#names_and_taxonomy" } ] }, { "name": "DNA (cytosine-5)-methyltransferase-like protein 2", "type": "synonym", "evidence": [ { "id": "NP_861528", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861528" }, { "id": "Q7YS61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS61/entry#names_and_taxonomy" } ] }, { "name": "DNA (cytosine-5-)-methyltransferase 2", "type": "synonym", "evidence": [ { "id": "NP_861528", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861528" } ] }, { "name": "Dnmt2", "type": "synonym", "evidence": [ { "id": "Q7YS61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS61/entry#names_and_taxonomy" } ] }, { "name": "tRNA (cytosine(38)-C(5))-methyltransferase", "type": "synonym", "evidence": [ { "id": "NP_861528", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861528" } ] }, { "name": "tRNA (cytosine-5-)-methyltransferase", "type": "synonym", "evidence": [ { "id": "NP_861528", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861528" } ] } ], "function": [ { "annotation": "Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp). Has higher activity on tRNA(Asp) modified with queuosine at position 34.", "evidence": [ { "database": "UniProtKB", "id": "Q7YS61", "url": "https://www.uniprot.org/uniprotkb/Q7YS61#function" }, { "database": "UniProtKB", "id": "O14717", "url": "https://www.uniprot.org/uniprotkb/O14717#function" }, { "database": "UniProtKB", "id": "A0AAF6Z7Y2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y2#function" }, { "database": "UniProtKB", "id": "ARBA00060360", "url": "https://www.uniprot.org/uniprotkb/ARBA00060360#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q7YS61", "url": "https://www.uniprot.org/uniprotkb/Q7YS61" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRDMT1", "url": "https://www.uniprot.org/uniprotkb/Q7YS61", "locus": { "chromosome": "13", "start_pos": 31562568, "end_pos": 31615015, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020546", "url": "https://www.ensembl.org/id/ENSBTAG00000020546" } ] } } ], "crossref": [ { "id": "Q7YS61", "url": "https://alphafold.ebi.ac.uk/entry/Q7YS61", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020546", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020546", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00315", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00315", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "353353", "url": "https://www.ncbi.nlm.nih.gov/gene/353353", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001525", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001525", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031303", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031303", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050750", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050750", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:353353", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:353353", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HYAFKYA", "url": "https://omabrowser.org/oma/group/HYAFKYA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LSK9", "url": "https://www.orthodb.org/?gene=A0A3Q1LSK9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q7YS61", "url": "https://www.orthodb.org/?gene=Q7YS61", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46098", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46098", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46098:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46098:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00145", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00145", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_861528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861528", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "42956", "url": "https://www.rhea-db.org/rhea/42956", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LSK9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSK9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSK9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJ60", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJ60", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJ60-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJ60-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM17", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM17-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z7Y2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z7Y2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z7Y2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7YS61", "url": "https://www.uniprot.org/uniprotkb/Q7YS61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7YS61-1", "url": "https://www.uniprot.org/uniprotkb/Q7YS61-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7YS61-2", "url": "https://www.uniprot.org/uniprotkb/Q7YS61-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPLRALELYSGIGGMHQALRESCIPAQVVAAVDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFNMILMSPPCQPFTRIGLQGDVTDPRTNSFLHILDILPRLQKLPKYILLENVKGFEMSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQPEPFPFQAPGQVLMEFPKTESEHPPKYAINAEKKTEEKKTGPKICFDSSTQCSGKEAILFKLETAGEIDRKHQQDSDLSVRMLKDFLEDDIDKHSFFLPPKSLLRYALLLDIVKPTSRRSMCFTKGYGRYIEGTGSVLQTTEDVQIENIYKSLTSLSQEEKIMRLSMLQLRFFTPKEIANLLGFPPEFGFPEMTTVKQRYRLLGNSLNVHVVAKLIKILCD", "length": 391, "header": "sp|Q7YS61-1|TRDMT_BOVIN Isoform 1 of tRNA (cytosine(38)-C(5))-methyltransferase OS=Bos taurus OX=9913 GN=TRDMT1 PE=2 SV=1 CANONICAL=Q7YS61-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSK9-1", "url": "https://www.uniprot.org/uniprotkb/Q7YS61/entry#A0A3Q1LSK9-1", "sequence": { "sequence": "MEPLRALELYSGIGGMHQALRESCIPAQVVAAVDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFNMILMSPPCQPFTRIGLQGDVTDPRTNSFLHILDILPRLQKLPKYILLENVKGFEMSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQPEPFPFQAPGQVLMEFPKTESEHPPKYAINAEKKTEEKKTGPKICFDSSTQCSGKEAILFKLETAGEIDRKHQQDSDLSVRMLKDFLEDDIDKHSFFLPPKSLLRYALLLDIVKPTSRRSMCFTKGYGRYIEGTGSVLQTTEDVQIENIYKSLTSLSQEEKIMRLSMLQLRFFTPKEIANLLGFPPEFGMWDTRGPQLSFINGLRTH", "length": 377, "header": "tr|A0A3Q1LSK9-1|TRDMT_BOVIN Computationally mapped isoform of tRNA (cytosine(38)-C(5))-methyltransferase OS=Bos taurus OX=9913 GN=TRDMT1 PE=2 SV=2 CANONICAL=Q7YS61-1" }, "locus": { "chromosome": "13", "start_pos": 31614344, "end_pos": 31568724, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071282.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071282.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058066.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058066.2" } ] } }, { "isoform_ac": "A0A3Q1MJ60-1", "url": "https://www.uniprot.org/uniprotkb/Q7YS61/entry#A0A3Q1MJ60-1", "sequence": { "sequence": "MEPLRALELYSGIGGMHQALRESCIPAQVVAAVDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFNMILMSPPCQPFTRIGLQGDVTDPRTNSFLHILDILPRLQKLPKYILLENVKGFEMSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQPEPFPFQAPGQVLMEFPKTESEHPPKYAINAEKKTEEKKTGPKICFDSSTQCSGKEAILFKLETAGEIDRKHQQDSDLSVRMLKDFLEDDIDKHSFFLPPKSLLRYALLLDIVKPTSRRSMCFTKGYGRYIEGTGSVLQTTEDVQIENIYKSLTSLSQEEKIMRLSMLQLRFFTPKEIANLLGFPPEFDVSSSLIQS", "length": 367, "header": "tr|A0A3Q1MJ60-1|TRDMT_BOVIN Computationally mapped isoform of tRNA (cytosine(38)-C(5))-methyltransferase OS=Bos taurus OX=9913 GN=TRDMT1 PE=2 SV=1 CANONICAL=Q7YS61-1" }, "locus": { "chromosome": "13", "start_pos": 31614344, "end_pos": 31564727, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072803.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072803.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070799.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070799.2" } ] } }, { "isoform_ac": "A0AAA9SM17-1", "url": "https://www.uniprot.org/uniprotkb/Q7YS61/entry#A0AAA9SM17-1", "sequence": { "sequence": "MEPLRALELYSGIGGMHQALRESCIPAQVVAAVDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFNMILMSPPCQPFTRIGLQGDVTDPRTNSFLHILDILPRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQPEPFPFQAPGQVLMEFPKTESEHPPKYAINAEKKTEEKKTGPKICFDSSTQCSGKEAILFKLETAGEIDRKHQQDSDLSVRMLKDFLEDDIDKHSFFLPPKSLLRYALLLDIVKPTSRRSMCFTKGYGRYIEGTGSVLQTTEDVQIENIYKSLTSLSQEEKIMRLSMLQLRFFTPKEIANLLGFPPEFGMWDTRGPQLSFINGLRTH", "length": 355, "header": "tr|A0AAA9SM17-1|TRDMT_BOVIN Computationally mapped isoform of tRNA (cytosine(38)-C(5))-methyltransferase OS=Bos taurus OX=9913 GN=TRDMT1 PE=2 SV=1 CANONICAL=Q7YS61-1" }, "locus": { "chromosome": "13", "start_pos": 31614344, "end_pos": 31568724, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105566.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105566.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084936.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084936.1" } ] } }, { "isoform_ac": "A0AAA9SZF7-1", "url": "https://www.uniprot.org/uniprotkb/Q7YS61/entry#A0AAA9SZF7-1", "sequence": { "sequence": "MEPLRALELYSGIGGMHQALRESCIPAQVVAAVDVNTVANEVYKYNFPHTQLLAKTIEVLMEFPKTESEHPPKYAINAEKKTEEKKTGPKICFDSSTQCSGKEAILFKLETAGEIDRKHQQDSDLSVRMLKDFLEDDIDKHSFFLPPKSLLRYALLLDIVKPTSRRSMCFTKGYGRYIEGTGSVLQTTEDVQIENIYKSLTSLSQEEKIMRLSMLQLRFFTPKEIANLLGFPPEFGMWDTRGPQLSFINGLRTH", "length": 254, "header": "tr|A0AAA9SZF7-1|TRDMT_BOVIN Computationally mapped isoform of tRNA (cytosine(38)-C(5))-methyltransferase OS=Bos taurus OX=9913 GN=TRDMT1 PE=2 SV=1 CANONICAL=Q7YS61-1" }, "locus": { "chromosome": "13", "start_pos": 31614344, "end_pos": 31568724, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108086.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108086.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088754.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088754.1" } ] } }, { "isoform_ac": "A0AAF6Z7Y2-1", "url": "https://www.uniprot.org/uniprotkb/Q7YS61/entry#A0AAF6Z7Y2-1", "sequence": { "sequence": "MRYMFKPNGRRVWTLLAFKEGKAASLKKSCIPAQVVAAVDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFNMILMSPPCQPFTRIGLQGDVTDPRTNSFLHILDILPRLQKLPKYILLENVKGFEMSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQPEPFPFQAPGQVLMEFPKTESEHPPKYAINAEKKTEEKKTGPKICFDSSTQCSGKEAILFKLETAGEIDRKHQQDSDLSVRMLKDFLEDDIDKHSFFLPPKSLLRYALLLDIVKPTSRRSMCFTKGYGRYIEGTGSVLQTTEDVQIENIYKSLTSLSQEEKIMRLSMLQLRFFTPKEIANLLGFPPEFGFPEMTTVKQRYRLLGNSLNVHVVAKLIKILCD", "length": 397, "header": "tr|A0AAF6Z7Y2-1|TRDMT_BOVIN Computationally mapped isoform of tRNA (cytosine(38)-C(5))-methyltransferase OS=Bos taurus OX=9913 GN=TRDMT1 PE=2 SV=1 CANONICAL=Q7YS61-1" }, "locus": { "chromosome": "13", "start_pos": 31615005, "end_pos": 31562692, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027378.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027378.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027378.5", "url": "https://www.ensembl.org/id/ENSBTAP00000027378.5" } ] } }, { "isoform_ac": "Q7YS61-1", "url": "https://www.uniprot.org/uniprotkb/Q7YS61/entry#Q7YS61-1", "sequence": { "sequence": "MEPLRALELYSGIGGMHQALRESCIPAQVVAAVDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFNMILMSPPCQPFTRIGLQGDVTDPRTNSFLHILDILPRLQKLPKYILLENVKGFEMSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQPEPFPFQAPGQVLMEFPKTESEHPPKYAINAEKKTEEKKTGPKICFDSSTQCSGKEAILFKLETAGEIDRKHQQDSDLSVRMLKDFLEDDIDKHSFFLPPKSLLRYALLLDIVKPTSRRSMCFTKGYGRYIEGTGSVLQTTEDVQIENIYKSLTSLSQEEKIMRLSMLQLRFFTPKEIANLLGFPPEFGFPEMTTVKQRYRLLGNSLNVHVVAKLIKILCD", "length": 391, "header": "sp|Q7YS61-1|TRDMT_BOVIN Isoform 1 of tRNA (cytosine(38)-C(5))-methyltransferase OS=Bos taurus OX=9913 GN=TRDMT1 PE=2 SV=1 CANONICAL=Q7YS61-1" }, "locus": {} }, { "isoform_ac": "Q7YS61-2", "url": "https://www.uniprot.org/uniprotkb/Q7YS61/entry#Q7YS61-2", "sequence": { "sequence": "MEPLRALELYSGIGGMHQALRESCIPAQVVAAVDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFNMILMSPPCQPFTRIGLQGDVTDPRTNSFLHILDILPRLQKLPKYILLENVKGFEMSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQPEPFPFQAPGQVLMEFPKTESEHPPKYAINAEKKTEEKKTGPKICFDSSTQCSGKEAILFKLETAGEIDRKHQQDSDLSVRMLKDFLEDDIDKHSFFLPPKSLLRYALLLDIVKPTSRRSMCFTKGYGRYIEGTGSVLQTTEDVQIENIYKSLTSLSQEEKIMRLSMLQLRFFTPKEIANLLGFPPEFGMWDTRGPQLSFINGLRT", "length": 376, "header": "sp|Q7YS61-2|TRDMT_BOVIN Isoform 2 of tRNA (cytosine(38)-C(5))-methyltransferase OS=Bos taurus OX=9913 GN=TRDMT1 PE=2 SV=1 CANONICAL=Q7YS61-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Analysis of DNA (cytosine 5) methyltransferase mRNA sequence and expression in bovine preimplantation embryos, fetal and adult tissues.", "journal": "Gene Expr. Patterns", "date": "2003", "authors": "Golding Michael C, Westhusin Mark E", "evidence": [ { "database": "UniProtKB", "id": "Q7YS61", "url": "https://www.uniprot.org/uniprotkb/Q7YS61" } ], "reference": [ { "type": "PubMed", "id": "12971987", "url": "https://glygen.org/publication/PubMed/12971987" } ] }, { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q7YS61", "url": "https://www.uniprot.org/uniprotkb/Q7YS61" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:353353", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:353353", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XGQ3-1", "protein_name": "tRNA aspartic acid methyltransferase 1", "gene_name": "TRDMT1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAALRVLELYSGIGGMHQALKESCICAEVVAAVDVNTLANEVYKHNFPSTPLWAKTIEGITLKEFDRLSFDMILMSPPCQPFTRIGLQGDVSDPRTKSFLYILDILPRLQKCPKYLLLENVKGFESSSARNELLRTLETCGFKYQEFLLSPTCLGIPNSRLRYFLIAKLHQEPFFFHVPGQILTRLPDQNLEELSKDKVVDKTGSSFPSGEKSLDSNTSPDCSSKKGPLPKGAFLFKLETAEQMVRKHRQDNDPSIQMLEDFLEEENEEMSQYFLAPKSLVRYAFLLDIVKPTCRRSTCFTKGYGHYVEGTGSVLQTAVDVELESVFKHIENLTEEEKLMKLSTLKLRYFTPREIANLHGFPPEFGMCSQSTHFYFILQLCQCSFLLGVMCAFYFASFFLTILTIQHFCLVFTNWLTFL", "length": 419 }, "evidence": [ { "id": "Q7YS61", "url": "https://omabrowser.org/oma/group/Q7YS61/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7K7C6-1", "protein_name": "tRNA (Cytosine(38)-C(5))-methyltransferase isoform X1", "gene_name": "Trdmt1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEPLRVLELYSGIGGMHHALRESCIPAHVVAAIDVNTVANEVYKHNFPHTHLLAKTIEGISLEEFDKLSFNMILMSPPCQPFTRIGLQGDMTDPRTNSFLYILDILPRLQKLPKYILLENVKGFEVSSTRGLLIQTIEACGFQHQEFLLSPSSLGIPNSRLRYFLIAKLQSEPLPFQAPDQILMEFPKIATIQTQSYAVVAENTLRVKRPEPSTCFDSSSTQYSRKDSILFKLETAEEIDRKHQQDNDLSVQMLKDFLEDEDTSQYFLPPKLLLRYALLLDIVKPTSRRSMCFTKGYGSYIEGTGSVLQTAEDVQIENVFKSLNDLPPEEKIAKLSTLKLRYFTPREIANLQGFPPEFVDQVCFLKTQVVLETHDPPASALQYWITGCTSRLS", "length": 393 }, "evidence": [ { "id": "Q7YS61", "url": "https://omabrowser.org/oma/group/Q7YS61/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F4JWT7-1", "protein_name": "tRNA (cytosine(38)-C(5))-methyltransferase 2", "gene_name": "DNMT2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAEQELQRINEKKPWQVLEFYSGIGGMRYSLMASGIVSEVVEAFEINDSANDVYQHNFKHRPYQGNIQSLTAADLDKYNADAWLLSPPCQPYTRQGLQKHSGDARAFSFLRILELIPHTTKPPQMLFVENVVGFETSDTHMEMIGTLTKLDYVTQEFILSPLQFGVPYSRPRYFCLAKRKPLPFKSQHSNNKLLWSPDPLYGRDDQVEFGKCQAEEGLDKLLEFCKPVEKFLELAAHVDGEPSSVDDSENGSKDCCGQEGDSVPDSVHQYLVPVSLIERWGNAMDIVYPDSKRCCCFTKSYYRYVKGTGSLLATVQPKIKGKESCLKEQRLRYFTPREVANFHSFPEDFEFPKHISLRQRYAMLGNSLSVAVVAPLLRYLFDS", "length": 383 }, "evidence": [ { "id": "Q7YS61", "url": "https://omabrowser.org/oma/group/Q7YS61/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "I3LF34-1", "protein_name": "tRNA (cytosine(38)-C(5))-methyltransferase", "gene_name": "TRDMT1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEPLRVLELYSGIGGMHQALRESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGVTLEEFDRLSFNMVLMSPPCQPFTRIGLQGDVTDPRTNSFLYILDILPRLQKLPKYILLENVKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPFPFQAPGQVLMEFPQMESEHPQKHAIDAQSKIEEKKIERNICLDSSAQCSGKEAILFKLETAGEIDRKHQQDSDLSVQMLKGFLEDDIDMNSYFLPPKSLLRYALLLDIVKPTSRRSMCFTKGYGRYIEGTGSVLQTSEDVQIENIYKSLTSLSPEEKIMKLLMLKLRFFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVHVVAKLIKILYE", "length": 391 }, "evidence": [ { "id": "Q7YS61", "url": "https://omabrowser.org/oma/group/Q7YS61/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O14717-1", "protein_name": "tRNA (cytosine(38)-C(5))-methyltransferase", "gene_name": "TRDMT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPLRVLELYSGVGGMHHALRESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLHILDILPRLQKLPKYILLENVKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESVHPQKYAMDVENKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVHVVAKLIKILYE", "length": 391 }, "evidence": [ { "id": "Q7YS61", "url": "https://omabrowser.org/oma/group/Q7YS61/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O55055-1", "protein_name": "tRNA (cytosine(38)-C(5))-methyltransferase", "gene_name": "Trdmt1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPLRVLELYSGIGGMHHALRESHIPAHVVAAIDVNTVANEVYKHNFPHTHLLSKTIEGISLEDFDKLSFNMILMSPPCQPFTRIGLQGDMTDPRTTSFLYILDILPRLQKLPKYILLENVKGFEVSSTRGLLIQTIEACGFQYQEFLLSPSSLGIPNSRLRYFLIAKLQSEPFPFQAPGQILMEFPKIVTVEPQKYAVVEESQPRVQRTGPRICAESSSTQSSGKDTILFKLETVEERDRKHQQDSDLSVQMLKDFLEDGDTDEYLLPPKLLLRYALLLDIVKPTSRRSMCFTKGYGSYIEGTGSVLQAAEDAQIENIYKSLPDLPPEEKIAKLSMLKLRYFTPKEIANLQGFPPEFGFPEKTTVKQRYRLLGNSLNVHVVAKLLTVLCEGFGNASESCHKMPLILDSNSKILS", "length": 415 }, "evidence": [ { "id": "Q7YS61", "url": "https://omabrowser.org/oma/group/Q7YS61/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q4G073-1", "protein_name": "tRNA (cytosine(38)-C(5))-methyltransferase", "gene_name": "Trdmt1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPLRVLELYSGIGGMHHALRESRVPAHVVAAIDVSTVANEVYKHNFPHTHLLAKTIEGISLEEFDKLSFNMILMSPPCQPFTRIGLQGDMSDRRTNSFLYILDILPRLQKLPKYILLENVKGFEVSSTRGLLIQTMEACGFQYQEFLLSPSSLGIPNSRLRYFLIAKLQSEPLCFQAPGQILMEFPNSGTVQPQEYAVVEEGKLRVRTREPDVCLDSSSTQCSGQDSILFKHETAADIDRKRQQDSDLSVQMLKGFLEDGDTAQYLLPAKSLLRYALLLDIVKPTSRRSMCFTKGYGSYIEGTGSVLQTAEDVQIENIYKSLPDLPPEEKIAKLSMLKLRYFTPKEIANLLGFPPEFGFPEKTTVKQRYRLLGNSLNVHVVSKLLTVLCE", "length": 391 }, "evidence": [ { "id": "Q7YS61", "url": "https://omabrowser.org/oma/group/Q7YS61/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q54JH6-1", "protein_name": "DNA (cytosine-5)-methyltransferase", "gene_name": "dnmA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEQLRVLEFYSGIGGMHYGLQESGVDFQVIQSFDINTNANLNYKYTFNEDSSQKSIESYSVEELEGFKANAWLMSPPCQPFTRLGLQKDDQDNRTNSFFHLLDVLTKIKDPPTYILIENVFGFAKKGSSNTRDHLLDTLIKMNYSFQEFHLSPQQFGLANQRLRYFCIAKRNGKLNFKKEQDKHNEKVDENKLNNNSNNNNEQNKYDNLKILDHIPGYDFHTTLEECDEISNYFDKDLTDDELYEKYKVPHNLLLSKGMLFDIKQKDSKTSNCVTKSYGKFIEGTGSIIQMDNNFKADINDNKSLIPLKLRYFSPKEITRLHGFPEEFKFSPKLTTIQCYRLIGNSLNVKIVSELLKVLVSPNEEEEQQEQQKEKEGKK", "length": 379 }, "evidence": [ { "id": "Q7YS61", "url": "https://omabrowser.org/oma/group/Q7YS61/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9VKB3-1", "protein_name": "tRNA (cytosine(38)-C(5))-methyltransferase", "gene_name": "Mt2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVFRVLELFSGIGGMHYAFNYAQLDGQIVAALDVNTVANAVYAHNYGSNLVKTRNIQSLSVKEVTKLQANMLLMSPPCQPHTRQGLQRDTEDKRSDALTHLCGLIPECQELEYILMENVKGFESSQARNQFIESLERSGFHWREFILTPTQFNVPNTRYRYYCIARKGADFPFAGGKIWEEMPGAIAQNQGLSQIAEIVEENVSPDFLVPDDVLTKRVLVMDIIHPAQSRSMCFTKGYTHYTEGTGSAYTPLSEDESHRIFELVKEIDTSNQDASKSEKILQQRLDLLHQVRLRYFTPREVARLMSFPENFEFPPETTNRQKYRLLGNSINVKVVGELIKLLTIK", "length": 345 }, "evidence": [ { "id": "Q7YS61", "url": "https://omabrowser.org/oma/group/Q7YS61/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "tRNA (cytidine-5-)-methyltransferase activity", "id": "GO:0016428", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016428", "evidence": [ { "database": "UniProtKB", "id": "Q7YS61", "url": "https://www.uniprot.org/uniprotkb/Q7YS61" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q7YS61", "url": "https://www.uniprot.org/uniprotkb/Q7YS61" } ], "pmid": "" }, { "name": "methyltransferase activity", "id": "GO:0008168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008168", "evidence": [ { "database": "UniProtKB", "id": "Q7YS61", "url": "https://www.uniprot.org/uniprotkb/Q7YS61" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q7YS61", "url": "https://www.uniprot.org/uniprotkb/Q7YS61" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q7YS61", "url": "https://www.uniprot.org/uniprotkb/Q7YS61" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "tRNA processing", "id": "GO:0008033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008033", "evidence": [ { "database": "UniProtKB", "id": "Q7YS61", "url": "https://www.uniprot.org/uniprotkb/Q7YS61" } ], "pmid": "" }, { "name": "tRNA methylation", "id": "GO:0030488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030488", "evidence": [ { "database": "UniProtKB", "id": "Q7YS61", "url": "https://www.uniprot.org/uniprotkb/Q7YS61" } ], "pmid": "" }, { "name": "tRNA stabilization", "id": "GO:0036416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036416", "evidence": [ { "database": "UniProtKB", "id": "Q7YS61", "url": "https://www.uniprot.org/uniprotkb/Q7YS61" } ], "pmid": "" }, { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "Q7YS61", "url": "https://www.uniprot.org/uniprotkb/Q7YS61" } ], "pmid": "" }, { "name": "tRNA modification", "id": "GO:0006400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006400", "evidence": [ { "database": "UniProtKB", "id": "Q7YS61", "url": "https://www.uniprot.org/uniprotkb/Q7YS61" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "42956", "name": "", "equation": "cytidine(38) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(38) in tRNA + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q7YS61-1" ], "evidence": [ { "id": "42956", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42956" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q7YS61", "gene_name": "TRDMT1", "activity": [ { "ec_number": "2.1.1.204", "activity": "cytidine(38) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(38) in tRNA + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "Q7YS61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS61" } ] }, { "ec_number": "2.1.1.204", "activity": "", "evidence": [ { "id": "Q7YS61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS61" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q7YS61-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 391, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q7YS61-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q7YS61" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q7YS61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS61" }, { "id": "PRU01016", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01016" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAM-dependent MTase C5-type", "eco_id": "ECO_0000255", "start_pos": 4, "end_pos": 391, "start_aa": "Leu", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], 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"total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZCL5-1", "uniprot_ac": "Q3ZCL5", "uniprot_id": "ARFP2_BOVIN", "mass": { "chemical_mass": 37711.0, "monoisotopic_mass": 37711.0 }, "refseq": { "ac": "NP_001029649", "name": "arfaptin-2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029649" }, "gene_names": [ { "name": "ARFIP2", "type": "recommended", "evidence": [ { "id": "Q3ZCL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5" } ] }, { "name": "ARFIP2", "type": "synonym", "evidence": [ { "id": "NP_001029649", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029649" } ] } ], "protein_names": [ { "name": "Arfaptin-2", "type": "recommended", "evidence": [ { "id": "Q3ZCL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5/entry#names_and_taxonomy" } ] }, { "name": "ADP-ribosylation factor interacting protein 2 (arfaptin 2)", "type": "synonym", "evidence": [ { "id": "NP_001029649", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029649" } ] }, { "name": "ADP-ribosylation factor-interacting protein 2", "type": "synonym", "evidence": [ { "id": "Q3ZCL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5/entry#names_and_taxonomy" } ] }, { "name": "arfaptin-2", "type": "synonym", "evidence": [ { "id": "NP_001029649", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029649" } ] } ], "function": [ { "annotation": "Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site. Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5#function" }, { "database": "UniProtKB", "id": "P53365", "url": "https://www.uniprot.org/uniprotkb/P53365#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARFIP2", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5", "locus": { "chromosome": "15", "start_pos": 46571924, "end_pos": 46566777, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003566", "url": "https://www.ensembl.org/id/ENSBTAG00000003566" } ] } } ], "crossref": [ { "id": "Q3ZCL5", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCL5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003566", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003566", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07660", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07660", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514938", "url": "https://www.ncbi.nlm.nih.gov/gene/514938", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030798", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030798", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514938", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514938", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M1F7", "url": "https://www.orthodb.org/?gene=A0A3Q1M1F7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NN77", "url": "https://www.orthodb.org/?gene=A0A3Q1NN77", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZCL5", "url": "https://www.orthodb.org/?gene=Q3ZCL5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12141", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12141", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12141:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12141:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06456", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06456", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029649", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1F7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1F7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1F7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1F7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NN77", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NN77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NN77-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NN77-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YLE9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YLE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLE9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCL5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTDGILGKAATMEIPIHGNGEAGQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSATPAGPGDEVARGIAGEKFDIVKKWGINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQAHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEKPSWLEEQ", "length": 341, "header": "sp|Q3ZCL5-1|ARFP2_BOVIN Isoform 1 of Arfaptin-2 OS=Bos taurus OX=9913 GN=ARFIP2 PE=2 SV=1 CANONICAL=Q3ZCL5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M1F7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5/entry#A0A3Q1M1F7-1", "sequence": { "sequence": "MKPALCLVAMGALVMDSSPQCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQAHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEKPSWLEEQ", "length": 256, "header": "tr|A0A3Q1M1F7-1|ARFP2_BOVIN Computationally mapped isoform of Arfaptin-2 OS=Bos taurus OX=9913 GN=ARFIP2 PE=2 SV=2 CANONICAL=Q3ZCL5-1" }, "locus": { "chromosome": "15", "start_pos": 46571341, "end_pos": 46568158, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069656.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069656.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063547.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063547.2" } ] } }, { "isoform_ac": "A0A3Q1NN77-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5/entry#A0A3Q1NN77-1", "sequence": { "sequence": "MTDGILGKAATMEIPIHGNGEAGQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSATPAGPGDEVARGIAGEKFDIVKKWGINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQPRGRTPPGWAQPRPQQHSPVEAA", "length": 202, "header": "tr|A0A3Q1NN77-1|ARFP2_BOVIN Computationally mapped isoform of Arfaptin-2 OS=Bos taurus OX=9913 GN=ARFIP2 PE=2 SV=1 CANONICAL=Q3ZCL5-1" }, "locus": { "chromosome": "15", "start_pos": 46569889, "end_pos": 46567767, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083945.3", "url": "https://www.ensembl.org/id/ENSBTAT00000083945.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074168.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074168.1" } ] } }, { "isoform_ac": "A0AAA9RVB5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5/entry#A0AAA9RVB5-1", "sequence": { "sequence": "MTDGILGKAATMEIPIHGNGEAGQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGKSFSCAGRGVGGEPQRCLMYLRETGVRELGPLGSGRHPSHSATPAGPGDEVARGIAGEKFDIVKKWGINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQAHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEKPSWLEEQ", "length": 374, "header": "tr|A0AAA9RVB5-1|ARFP2_BOVIN Computationally mapped isoform of Arfaptin-2 OS=Bos taurus OX=9913 GN=ARFIP2 PE=2 SV=1 CANONICAL=Q3ZCL5-1" }, "locus": { "chromosome": "15", "start_pos": 46571341, "end_pos": 46567767, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100567.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100567.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076230.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076230.1" } ] } }, { "isoform_ac": "A0AAF6YLE9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5/entry#A0AAF6YLE9-1", "sequence": { "sequence": "MGEGKGAGVETLTPVPSLAMTDGILGKAATMEIPIHGNGEAGQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSATPAGPGDEVARGIAGEKFDIVKKWGINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQAHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEKPSWLEEQ", "length": 360, "header": "tr|A0AAF6YLE9-1|ARFP2_BOVIN Computationally mapped isoform of Arfaptin-2 OS=Bos taurus OX=9913 GN=ARFIP2 PE=2 SV=1 CANONICAL=Q3ZCL5-1" }, "locus": { "chromosome": "15", "start_pos": 46571341, "end_pos": 46566935, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004638.4", "url": "https://www.ensembl.org/id/ENSBTAT00000004638.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004638.3", "url": "https://www.ensembl.org/id/ENSBTAP00000004638.3" } ] } }, { "isoform_ac": "Q3ZCL5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5/entry#Q3ZCL5-1", "sequence": { "sequence": "MTDGILGKAATMEIPIHGNGEAGQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSATPAGPGDEVARGIAGEKFDIVKKWGINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQAHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEKPSWLEEQ", "length": 341, "header": "sp|Q3ZCL5-1|ARFP2_BOVIN Isoform 1 of Arfaptin-2 OS=Bos taurus OX=9913 GN=ARFIP2 PE=2 SV=1 CANONICAL=Q3ZCL5-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 76, "start_aa": "Thr", "end_pos": 76, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr76", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 72, "end_pos": 72, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5" } ], "site_lbl": "Ser72" }, { "start_pos": 76, "end_pos": 76, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5" } ], "site_lbl": "Thr76" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:514938", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514938", "resource": "KEGG Pathway" }, { "id": "R-BTA-6811440", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "resource": "Reactome", "description": "Retrograde transport at the Trans-Golgi-Network" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M9Q652-1", "protein_name": "Arfaptin-2b isoform X8", "gene_name": "arfip2b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MADSMMSKAATMEIPISSNGDSRNLAEDDSLEQDLQQVMVSGPNLNETSIVSGGYGGTTEGIIPTSSIKGSNMDYVGSNSSMAAEEATRGVAVEKFDIMKKWGLNTYKCTKQMISERFGRGSRTVDLELEAQIEVLRETKRKYENVLRLARALTNHFYSMVQTQHALGDTFADLSQKSPELRDEFGYNAETQKLLCKNGETLLGAINFFVSSINTLVNKTMEDTLMTIKMYENARLEFDAYRADLEELNMGPRDAVTMARIEAAQQQYQIHKDKYERLRSDVTIKIKFLEENKVKVMHKQLLLFHNAISAYFAGNQQQLEQTLKQFNIKLKPPGADKPSWLEEQ", "length": 344 }, "evidence": [ { "id": "Q3ZCL5", "url": "https://omabrowser.org/oma/group/Q3ZCL5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3IDF4-1", "protein_name": "Arfaptin-2 isoform X1", "gene_name": "Arfip2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTDGILGKAATMEIPIHGNGEAGQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSTSPSGPGDEVARGIAGEKFDIVKKWGINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQTHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEKPSWLEEQ", "length": 341 }, "evidence": [ { "id": "Q3ZCL5", "url": "https://omabrowser.org/oma/group/Q3ZCL5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P53365-1", "protein_name": "Arfaptin-2", "gene_name": "ARFIP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTDGILGKAATMEIPIHGNGEARQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSTTPSGPGDEVARGIAGEKFDIVKKWGINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQAHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEKPSWLEEQ", "length": 341 }, "evidence": [ { "id": "Q3ZCL5", "url": "https://omabrowser.org/oma/group/Q3ZCL5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6AY65-1", "protein_name": "Arfaptin-2", "gene_name": "Arfip2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTDGILGKAATMEIPIHGNGEAGQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSTSPSGPGDEVARGIAGEKFDIVKKWGINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQTHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEKPSWLEEQ", "length": 341 }, "evidence": [ { "id": "Q3ZCL5", "url": "https://omabrowser.org/oma/group/Q3ZCL5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8K221-1", "protein_name": "Arfaptin-2", "gene_name": "Arfip2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTDGILGKAATMEIPIHGNGEAGQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSTSPSGPGDEVARGIAGEKFDIVKKWGINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQTHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEKPSWLEEQ", "length": 341 }, "evidence": [ { "id": "Q3ZCL5", "url": "https://omabrowser.org/oma/group/Q3ZCL5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5" } ], "pmid": "" }, { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": 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"UniProtKB", "id": "Q3ZCL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5" } ], "pmid": "" }, { "name": "trans-Golgi network membrane", "id": "GO:0032588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032588", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5" } ], "pmid": "" }, { "name": "ruffle", "id": "GO:0001726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001726", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5" } ], "pmid": "" }, { "name": "protein localization to phagophore assembly site", "id": "GO:0034497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034497", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5" } ], "pmid": "" }, { "name": "regulation of Arp2/3 complex-mediated actin nucleation", "id": "GO:0034315", "url": 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"n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCL5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 341, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCL5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCL5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZCL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCL5" }, { "id": "PRU00294", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00294" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AH", "eco_id": "ECO_0000255", "start_pos": 121, "end_pos": 321, "start_aa": "Thr", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], 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"sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "A6QP05-1", "uniprot_ac": "A6QP05", "uniprot_id": "DHR12_BOVIN", "mass": { "chemical_mass": 35065.0, "monoisotopic_mass": 35065.0 }, "refseq": { "ac": "NP_001093783", "name": "dehydrogenase/reductase SDR family member 12", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093783" }, "gene_names": [ { "name": "DHRS12", "type": "recommended", "evidence": [ { "id": "A6QP05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP05" } ] }, { "name": "DHRS12", "type": "synonym", "evidence": [ { "id": "NP_001093783", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093783" } ] }, { "name": "SDR40C1", "type": "synonym", "evidence": [ { "id": "A6QP05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP05" } ] } ], "protein_names": [ { "name": "Dehydrogenase/reductase SDR family member 12", "type": "recommended", "evidence": [ { "id": "A6QP05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP05/entry#names_and_taxonomy" } ] }, { "name": "1.1.-.-", "type": "synonym", "evidence": [ { "id": "A6QP05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP05/entry#names_and_taxonomy" } ] }, { "name": "Protein SDR40C1", "type": "synonym", "evidence": [ { "id": "A6QP05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP05/entry#names_and_taxonomy" } ] }, { "name": "Short-chain dehydrogenase/reductase family 40C member 1", "type": "synonym", "evidence": [ { "id": "A6QP05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP05/entry#names_and_taxonomy" } ] }, { "name": "dehydrogenase/reductase SDR family member 12", "type": "synonym", "evidence": [ { "id": "NP_001093783", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093783" } ] }, { "name": "short-chain dehydrogenase/reductase family 40C member 1", "type": "synonym", "evidence": [ { "id": "NP_001093783", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093783" } ] } ], "function": [ { "annotation": "Putative oxidoreductase.", "evidence": [ { "database": "UniProtKB", "id": "A6QP05", "url": "https://www.uniprot.org/uniprotkb/A6QP05#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QP05", "url": "https://www.uniprot.org/uniprotkb/A6QP05" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DHRS12", "url": "https://www.uniprot.org/uniprotkb/A6QP05", "locus": { "chromosome": "12", "start_pos": 21205837, "end_pos": 21246108, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016109", "url": "https://www.ensembl.org/id/ENSBTAG00000016109" } ] } } ], "crossref": [ { "id": "A6QP05", "url": "https://alphafold.ebi.ac.uk/entry/A6QP05", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016109", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016109", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09808", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09808", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507276", "url": "https://www.ncbi.nlm.nih.gov/gene/507276", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507276", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507276", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M3R6", "url": "https://www.orthodb.org/?gene=A0A3Q1M3R6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MFN4", "url": "https://www.orthodb.org/?gene=A0A3Q1MFN4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A6QP05", "url": "https://www.orthodb.org/?gene=A6QP05", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44656", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44656", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44656:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44656:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00106", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00106", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001093783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093783", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3R6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3R6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFN4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFN4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFN4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC59", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC59-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC59-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z261", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z261", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z261-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z261-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QP05", "url": "https://www.uniprot.org/uniprotkb/A6QP05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QP05-1", "url": "https://www.uniprot.org/uniprotkb/A6QP05-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLYRSAAWFAKGLREYTKSGYESASKDFVPDDLEVQVPGRAFMVTGGNSGIGKATAMEIAKRGGTVHLVCRDHSRAEGAKAEIIRESGNQNIFLHIVDLSLPKSVWKFVENFKQEHTLNVLINNAGCMVNKRELTEDGLEKNFATNTLGVYVLTTALIPVLEKEHDPRVITVSSGGMLVQKLNTDDPQSERTAFDGTMVYAQNKRQQVVLTERWARAHPAIHFSCMHPGWVDTPGVRLSMPGFHARLGARLRSEAQGADTVLWLALAPAATAQPSGCFFQDRKPAPTHLPLARTSSSPAEEEKLIEILEELARRFK", "length": 317, "header": "sp|A6QP05-1|DHR12_BOVIN Isoform 1 of Dehydrogenase/reductase SDR family member 12 OS=Bos taurus OX=9913 GN=DHRS12 PE=2 SV=1 CANONICAL=A6QP05-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M3R6-1", "url": "https://www.uniprot.org/uniprotkb/A6QP05/entry#A0A3Q1M3R6-1", "sequence": { "sequence": "MLLYRSAAWFAKGLREYTKSGYESASKDFVPDDLEVQVPGRAFMVTGGNSGIGKATAMEIAKRGGTVHLVCRDHSRAEGAKAEIIRESGNQNIFLHIVDLSLPKSVWKFVENFKQEHTLNVLINNAGCMVNKRELTEDGLEKNFATNTLGVYVLTTALIPVLEKEHDPRVITVSSGGMLVQKLNTDDPQSERTAFDGTMVYAQNKERESSSPSEAQLSSAWTRVEVRGFSSPRGGATKAATSLPEYLRPTRRVVRAGDPHSRTQQRLLVLRGSERKWTQGVPSLPLGSPCSLAGWIPPEPCWVSGSLCGVRTQLLQSCLTLCNPMDCSPPGSSVQGILQARILGWVVMPSSRGSSRPRNRTCVSHVSCTGRQVLYH", "length": 376, "header": "tr|A0A3Q1M3R6-1|DHR12_BOVIN Computationally mapped isoform of Dehydrogenase/reductase SDR family member 12 OS=Bos taurus OX=9913 GN=DHRS12 PE=2 SV=1 CANONICAL=A6QP05-1" }, "locus": { "chromosome": "12", "start_pos": 21246077, "end_pos": 21211031, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076501.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076501.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064413.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064413.1" } ] } }, { "isoform_ac": "A0A3Q1MFN4-1", "url": "https://www.uniprot.org/uniprotkb/A6QP05/entry#A0A3Q1MFN4-1", "sequence": { "sequence": "MLLYRSAAWFAKGLREYTKSGYESASKDFVPDDLEVQVPGRAFMVTGGNSGIGKATAMEIAKRGGTVHLVCRDHSRAEGAKAEIIRESGNQNIFLHIVDLSLPKSVWKFVENFKQEHTLNVLINNAGCMVNKRELTEDGLEKNFATNTLGVYVLTTALIPVLEKEHDPRVITVSSGGMLVQKLNTDDPQSERTAFDGTMVYAQNKRQQVVLTERWARAHPAIHFSCMHPGWVDTPGHHPDGPHINLCAGRVCAPRSPPESSIWVRVRSAICGPQVCGCRCRASTPGWGPGCAPRPRARTRCCGWPLPPLPPPSPAAASSKTGNRRPHTCLSRGHRPHRPKRRNSLRSWKSWLGDLNSPG", "length": 359, "header": "tr|A0A3Q1MFN4-1|DHR12_BOVIN Computationally mapped isoform of Dehydrogenase/reductase SDR family member 12 OS=Bos taurus OX=9913 GN=DHRS12 PE=2 SV=2 CANONICAL=A6QP05-1" }, "locus": { "chromosome": "12", "start_pos": 21246077, "end_pos": 21206354, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071572.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071572.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069957.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069957.2" } ] } }, { "isoform_ac": "A0AAA9TC59-1", "url": "https://www.uniprot.org/uniprotkb/A6QP05/entry#A0AAA9TC59-1", "sequence": { "sequence": "MLLYRSAAWFAKGLREYTKSGYESASKDFVPDDLEVQVPGRAFMVTGGNSGIGKATAMEIAKRGGTVHLVCRDHSRAEGAKAEIIRESGNQNIFLHIVDLSLPKSVWKFVENFKQEHTLNVLINNAGCMVNKRELTEDGLEKNFATNTLGVYVLTTALIPVLEKEHDPRVITVSSGGMLVQKLNTDDPQSERTAFDGTMVYAQNKRQQVVLTERWARAHPAIHFSCMHPGWVDTPGHHPDGPHINLCAGRVCAPRSPPESSIWVRVRSAICGPQVTGPRLGFSEAADWASVSRGRAGEGPEPTDTRPPRVV", "length": 311, "header": "tr|A0AAA9TC59-1|DHR12_BOVIN Computationally mapped isoform of Dehydrogenase/reductase SDR family member 12 OS=Bos taurus OX=9913 GN=DHRS12 PE=2 SV=1 CANONICAL=A6QP05-1" }, "locus": { "chromosome": "12", "start_pos": 21246077, "end_pos": 21208411, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110950.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110950.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094433.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094433.1" } ] } }, { "isoform_ac": "A0AAF6Z261-1", "url": "https://www.uniprot.org/uniprotkb/A6QP05/entry#A0AAF6Z261-1", "sequence": { "sequence": "MSLRPRTLSLMTWRSKFPEEPSWSLGGTAASEKRPPWRSPSENIFLHIVDLSLPKSVWKFVENFKQEHTLNVLINNAGCMVNKRELTEDGLEKNFATNTLGVYVLTTALIPVLEKEHDPRVITVSSGGMLVQKLNTDDPQSERTAFDGTMVYAQNKRQQVVLTERWARAHPAIHFSCMHPGWVDTPGVRLSMPGFHARLGARLRSEAQGADTVLWLALAPAATAQPSGCFFQDRKPAPTHLPLARTSSSPAEEEKLIEILEELARRFK", "length": 268, "header": "tr|A0AAF6Z261-1|DHR12_BOVIN Computationally mapped isoform of Dehydrogenase/reductase SDR family member 12 OS=Bos taurus OX=9913 GN=DHRS12 PE=2 SV=1 CANONICAL=A6QP05-1" }, "locus": { "chromosome": "12", "start_pos": 21235874, "end_pos": 21206364, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021443.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021443.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021443.5", "url": "https://www.ensembl.org/id/ENSBTAP00000021443.5" } ] } }, { "isoform_ac": "A6QP05-1", "url": "https://www.uniprot.org/uniprotkb/A6QP05/entry#A6QP05-1", "sequence": { "sequence": "MLLYRSAAWFAKGLREYTKSGYESASKDFVPDDLEVQVPGRAFMVTGGNSGIGKATAMEIAKRGGTVHLVCRDHSRAEGAKAEIIRESGNQNIFLHIVDLSLPKSVWKFVENFKQEHTLNVLINNAGCMVNKRELTEDGLEKNFATNTLGVYVLTTALIPVLEKEHDPRVITVSSGGMLVQKLNTDDPQSERTAFDGTMVYAQNKRQQVVLTERWARAHPAIHFSCMHPGWVDTPGVRLSMPGFHARLGARLRSEAQGADTVLWLALAPAATAQPSGCFFQDRKPAPTHLPLARTSSSPAEEEKLIEILEELARRFK", "length": 317, "header": "sp|A6QP05-1|DHR12_BOVIN Isoform 1 of Dehydrogenase/reductase SDR family member 12 OS=Bos taurus OX=9913 GN=DHRS12 PE=2 SV=1 CANONICAL=A6QP05-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:507276", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507276", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "A6QP05", "url": "https://www.uniprot.org/uniprotkb/A6QP05" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QP05-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 317, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QP05-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QP05" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QLZ7-1", "uniprot_ac": "A6QLZ7", "uniprot_id": "CRLD2_BOVIN", "mass": { "chemical_mass": 55581.0, "monoisotopic_mass": 55581.0 }, "refseq": { "ac": "NP_001093769", "name": "cysteine-rich secretory protein LCCL domain-containing 2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093769" }, "gene_names": [ { "name": "CRISPLD2", "type": "recommended", "evidence": [ { "id": "A6QLZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7" } ] }, { "name": "CRISPLD2", "type": "synonym", "evidence": [ { "id": "NP_001093769", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093769" } ] } ], "protein_names": [ { "name": "Cysteine-rich secretory protein LCCL domain-containing 2", "type": "recommended", "evidence": [ { "id": "A6QLZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7/entry#names_and_taxonomy" } ] }, { "name": "cysteine-rich secretory protein LCCL domain-containing 2 precursor", "type": "synonym", "evidence": [ { "id": "NP_001093769", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093769" } ] } ], "function": [ { "annotation": "Promotes matrix assembly.", "evidence": [ { "database": "UniProtKB", "id": "A6QLZ7", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QLZ7", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CRISPLD2", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7", "locus": { "chromosome": "18", "start_pos": 11046041, "end_pos": 10996841, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021176", "url": "https://www.ensembl.org/id/ENSBTAG00000021176" } ] } } ], "crossref": [ { "id": "A6QLZ7", "url": "https://alphafold.ebi.ac.uk/entry/A6QLZ7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021176", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021176", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505329", "url": "https://www.ncbi.nlm.nih.gov/gene/505329", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004043", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004043", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018244", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018244", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036609", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036609", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505329", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505329", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WVQPRVT", "url": "https://omabrowser.org/oma/group/WVQPRVT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MC95", "url": "https://www.orthodb.org/?gene=A0A3Q1MC95", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A6QLZ7", "url": "https://www.orthodb.org/?gene=A6QLZ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31331", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31331", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31331:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31331:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00188", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00188", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03815", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03815", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001093769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093769", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC95", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC95-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC95-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2T3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2T3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2T3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z9B2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9B2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z9B2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z9B2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QLZ7", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QLZ7-1", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSCVLTGVVPLGLVLLLCGAQGFFLPNVTQLEKLLSKYQGDQPHSRTRRAISRADREEILTLHNKLRGQVSPPASNMEYMTWDEELEKSAVAWARECIWEHGPTSLLVSIGQNLAVHWGRPRSPGSHVQSWYDEVKDYTYPYPHECNPWCPERCSGPMCTHYTQIVWATTNRIGCAVNTCPRMNVWGDVWENAVYLVCNYFPKGNWIGEAPYKTGQPCSECPGKYRGGCKNNLCYQETYGQETETDDMNEVEAAPIPDEKHVWVTPRVIKPKKPKKDSPVNYMTQVVKCDTKMKDKCKGSTCNRYQCPAGCLHSGAKIFGTLFYESASSICRAAIHYGILDDRGGLVDVTRNGKVPFFVKSERNGVQSLSKYKASSSFTVSKVKVQDLDCYTTVAQLCPYEKPGTHCPRVRCPAHCKDEPSYWAPVFGSNIYADTSSICKTAVHAGVIRNESGGYVDVMPVDKKKTYVASLRNGVQSESLRTPRDGKAFRIFAVRQ", "length": 496, "header": "sp|A6QLZ7-1|CRLD2_BOVIN Isoform 1 of Cysteine-rich secretory protein LCCL domain-containing 2 OS=Bos taurus OX=9913 GN=CRISPLD2 PE=2 SV=1 CANONICAL=A6QLZ7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MC95-1", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7/entry#A0A3Q1MC95-1", "sequence": { "sequence": "MSCVLTGVVPLGLVLLLCGAQGFFLPNVTQLEKLLSKYQGDQPHSRTRRAISRADREEILTLHNKLRGQVSPPASNMEYMTWDEELEKSAVAWARECIWEHGPTSLLVSIGQNLAVHWGRPRSPGSHVQSWYDEVKDYTYPYPHECNPWCPERCSGPMCTHYTQIVWATTNRIGCAVNTCPRMNVWGDVWENAVYLVCNYFPKGNWIGEAPYKTGQPCSECPGKYRGGCKNNLCYQETYGQETETDDMNEVEAAPIPDEKHVWVTPRVIKPKKPKKDSPVNYMTQVVKCDTKMKDKCKGSTCNRYQCPAGCLHSGAKIFGTLFYESASSICRAAIHYGILDDRGGLVDVTRNGKVPFFVKSERNGVQSLRLRPAHDLLLPFTVQDLDCYTTVAQLCPYEKPGTHCPRVRCPAHCKDEPSYWAPVFGSNIYADTSSICKTAVHAGVIRNESGGYVDVMPVDKKKTYVASLRNGVQSER", "length": 477, "header": "tr|A0A3Q1MC95-1|CRLD2_BOVIN Computationally mapped isoform of Cysteine-rich secretory protein LCCL domain-containing 2 OS=Bos taurus OX=9913 GN=CRISPLD2 PE=2 SV=1 CANONICAL=A6QLZ7-1" }, "locus": { "chromosome": "18", "start_pos": 11032957, "end_pos": 10996917, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080191.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080191.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066377.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066377.1" } ] } }, { "isoform_ac": "A0AAA9S2T3-1", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7/entry#A0AAA9S2T3-1", "sequence": { "sequence": "MSCVLTGVVPLGLVLLLCGAQGFFLPNVTQLEKLLSKYQGDQPHSRTRRAISRADREEILTLHNKLRGQVSPPASNMEYMTWDEELEKSAVAWARECIWEHGPTSLLVSIGQNLAVHWGRPRSPGSHVQSWYDEVKDYTYPYPHECNPWCPERCSGPMCTHYTQIVWATTNRIGCAVNTCPRMNVWGDVWENAVYLVCNYFPKGNWIGEAPYKTGQPCSECPGKYRGGCKNNLCYQEETYGQETETDDMNEVEAAPIPDEKHVWVTPRVIKPKKPKKDSPVNYMTQVVKCDTKMKDKCKGSTCNRYQCPAGCLHSGAKIFGTLFYESASSICRAAIHYGILDDRGGLVDVTRNGKVPFFVKSERNGVQSLSKYKASSSFTVSKVKVQDLDCYTTVAQLCPYEKPGTHCPRVRCPAHCKDEPSYWAPVFGSNIYADVSILPYRPPHRN", "length": 447, "header": "tr|A0AAA9S2T3-1|CRLD2_BOVIN Computationally mapped isoform of Cysteine-rich secretory protein LCCL domain-containing 2 OS=Bos taurus OX=9913 GN=CRISPLD2 PE=2 SV=1 CANONICAL=A6QLZ7-1" }, "locus": { "chromosome": "18", "start_pos": 11026636, "end_pos": 10996917, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088668.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088668.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079373.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079373.1" } ] } }, { "isoform_ac": "A0AAF6Z9B2-1", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7/entry#A0AAF6Z9B2-1", "sequence": { "sequence": "MSCVLTGVVPLGLVLLLCGAQGFFLPNVTQLEKLLSKYQGDQPHSRTRRAISRADREEILTLHNKLRGQVSPPASNMEYMTWDEELEKSAVAWARECIWEHGPTSLLVSIGQNLAVHWGRPRSPGSHVQSWYDEVKDYTYPYPHECNPWCPERCSGPMCTHYTQIVWATTNRIGCAVNTCPRMNVWGDVWENAVYLVCNYFPKGNWIGEAPYKTGQPCSECPGKYRGGCKNNLCYQEETYGQETETDDMNEVEAAPIPDEKHVWVTPRVIKPKKPKKDSPVNYMTQVVKCDTKMKDKCKGSTCNRYQCPAGCLHSGAKIFGTLFYESASSICRAAIHYGILDDRGGLVDVTRNGKVPFFVKSERNGVQSLSKYKASSSFTVSKVKVQDLDCYTTVAQLCPYEKPGTHCPRVRCPAHCKDEPSYWAPVFGSNIYADTSSICKTAVHAGVIRNESGGYVDVMPVDKKKTYVASLRNGVQSESLRTPRDGKAFRIFAVRQ", "length": 497, "header": "tr|A0AAF6Z9B2-1|CRLD2_BOVIN Computationally mapped isoform of Cysteine-rich secretory protein LCCL domain-containing 2 OS=Bos taurus OX=9913 GN=CRISPLD2 PE=2 SV=1 CANONICAL=A6QLZ7-1" }, "locus": { "chromosome": "18", "start_pos": 11043717, "end_pos": 10996917, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028221.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028221.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028221.6", "url": "https://www.ensembl.org/id/ENSBTAP00000028221.6" } ] } }, { "isoform_ac": "A6QLZ7-1", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7/entry#A6QLZ7-1", "sequence": { "sequence": "MSCVLTGVVPLGLVLLLCGAQGFFLPNVTQLEKLLSKYQGDQPHSRTRRAISRADREEILTLHNKLRGQVSPPASNMEYMTWDEELEKSAVAWARECIWEHGPTSLLVSIGQNLAVHWGRPRSPGSHVQSWYDEVKDYTYPYPHECNPWCPERCSGPMCTHYTQIVWATTNRIGCAVNTCPRMNVWGDVWENAVYLVCNYFPKGNWIGEAPYKTGQPCSECPGKYRGGCKNNLCYQETYGQETETDDMNEVEAAPIPDEKHVWVTPRVIKPKKPKKDSPVNYMTQVVKCDTKMKDKCKGSTCNRYQCPAGCLHSGAKIFGTLFYESASSICRAAIHYGILDDRGGLVDVTRNGKVPFFVKSERNGVQSLSKYKASSSFTVSKVKVQDLDCYTTVAQLCPYEKPGTHCPRVRCPAHCKDEPSYWAPVFGSNIYADTSSICKTAVHAGVIRNESGGYVDVMPVDKKKTYVASLRNGVQSESLRTPRDGKAFRIFAVRQ", "length": 496, "header": "sp|A6QLZ7-1|CRLD2_BOVIN Isoform 1 of Cysteine-rich secretory protein LCCL domain-containing 2 OS=Bos taurus OX=9913 GN=CRISPLD2 PE=2 SV=1 CANONICAL=A6QLZ7-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 265, "start_aa": "Thr", "end_pos": 265, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr265", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 27, "start_aa": "Asn", "end_pos": 27, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn27", "evidence": [ { "id": "A6QLZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:505329", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505329", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JUW3-1", "protein_name": "Cysteine-rich secretory protein LCCL domain containing 2", "gene_name": "Crispld2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGVIPGCCEVPEQSFMPLVIHLSNSLRHFQLKINLVFTEAQRLREERASLTRCQNLPVPSPTSGVPCPLSRGCRRGAMSCLLNNMVPVGLALLVCGVQAFFLPNTMSLERLLSKYQHTEPHSRVRRAIPMSDRQEILMLHNKLRGQVYPPASNMEYMTWDEELERSAAAWAQRCLWEHGPASLLVSIGQNLAVHWGRYRSPGFHVQSWYDEVKDYTYPYPHECNPWCPERCSGAMCTHYTQMVWATTNKIGCAVHTCRSMSVWGDIWENAVYLVCNYSPKGNWIGEAPYKHGRPCSECPSSYGGGCRNNLCYREEHYHQKPEVDEMNEVESPPAPEETHVWVQPRVVKPSKTKKTPVVNFMTQVVHCDTKMKDSCKGSTCNRYQCPAGCLNNKAKVFGSLFYESSSSICRAAIHYGVIDDRGGLVDVTRNGMVPFFVKSQKNGLESLSKYKPSSSFTVSKVKETAVDCHTTVAQLCPFEKPATHCPRVRCPSRCGEEPSYWAPVYGTNIYADTSSICKAAVHAGVIVDEVGGYADVMPVDKKKSYVGSLRNGVQSESPSTPQNGNAFRIFPVRQ", "length": 574 }, "evidence": [ { "id": "A6QLZ7", "url": "https://omabrowser.org/oma/group/A6QLZ7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "K7GSW9-1", "protein_name": "Cysteine rich secretory protein LCCL domain containing 2", "gene_name": "CRISPLD2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRCVLHGIPALGLALLVCGAQGFFLPNVTHLEKLLSKYQQDRPHSRARRAIPRVDQEEILMLHNKLRGQVSPPASNMEHMTWDEELARSAAAWAQECIWEHGPTSLLVSIGQNLAVHWGRYRSPGFHVQSWYDEVKDYTYPYPHECNPWCPERCSGAMCTHYTQIVWATTTKIGCAVNTCRRMNVWGDVWENAVYLVCNYSPKGNWIGEAPYKTGRPCSQCPPSYGGGCRNNLCYREETFHQKPETDEMNEVETAPNPEEKHVWVQPRVIRPTKPKKAPAVSYMTQVIKCDTKMKDKCKGSTCNRYQCPAGCLHNRAKIFGTLFYESASSICRAAIHYGILDDKGGLVDVTRNGKVPFFVKSERNGVQSLSKYKASSSFTVSKVKVQDLDCYTTVAQLCPFEKSGTHCPRVRCPAYCKDEPSYWAPVFGSNIYADTSSICKTAVHAGVIKNDSGGYVDVMPVDKKKTYVGSLRNGVQSESLRTPRDGKAFRIFAVRQ", "length": 497 }, "evidence": [ { "id": "A6QLZ7", "url": "https://omabrowser.org/oma/group/A6QLZ7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8BZQ2-1", "protein_name": "Cysteine-rich secretory protein LCCL domain-containing 2", "gene_name": "Crispld2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSCLLNNMVLMGLALLVCGVQAFFLPNTTSLEKLLSKYQHAEPHSRVRRAIPMSDRQEILMLHNKLRGQVYPPASNMEHMTWDEELERSAAAWAHRCLWEHGPAGLLRSIGQNLAVHWGRYRSPGFHVQSWYDEVKDYTYPYPHECTPRCRERCSGPMCTHYTQMVWATTNKIGCAVHTCRNMNVWGDTWENAVYLVCNYSPKGNWIGEAPYKHGRPCSECPSSYGGGCLNNLCHRAEKPHKHKPEVDMMNEVESPPAPEETHVWVQPRVIKTKKTPVINFMTQVVHCDTKMKDSCKGSTCNRYQCPAGCLSNKAKVFGSLFYESSSSICRAAIHYGVIDDRGGLVDVTRNGMVPFFVKSQKNGMESLSKYKPSSSFTVSKVTETAVDCHATVAQLCPFEKPATHCPRIQCPARCGEEPSYWAPVYGTNIYADTSSICKAAVHAGVIVDEVGGYADVMPVDKKKSYVGSLRNGVQSESLNTPQNGNAFRIFAVRQ", "length": 495 }, "evidence": [ { "id": "A6QLZ7", "url": "https://omabrowser.org/oma/group/A6QLZ7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H0B8-1", "protein_name": "Cysteine-rich secretory protein LCCL domain-containing 2", "gene_name": "CRISPLD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSCVLGGVIPLGLLFLVCGSQGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRGQVQPQASNMEYMTWDDELEKSAAAWASQCIWEHGPTSLLVSIGQNLGAHWGRYRSPGFHVQSWYDEVKDYTYPYPSECNPWCPERCSGPMCTHYTQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFVCNYSPKGNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPIPEENHVWLQPRVMRPTKPKKTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKAKIFGTLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSSSFMVSKVKVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTSSICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ", "length": 497 }, "evidence": [ { "id": "A6QLZ7", "url": "https://omabrowser.org/oma/group/A6QLZ7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A6QLZ7", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A6QLZ7", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A6QLZ7", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7" } ], "pmid": "" }, { "name": "transport vesicle", "id": "GO:0030133", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030133", "evidence": [ { "database": "UniProtKB", "id": "A6QLZ7", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "face morphogenesis", "id": "GO:0060325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060325", "evidence": [ { "database": "UniProtKB", "id": "A6QLZ7", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "glycosaminoglycan binding", "id": "GO:0005539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005539", "evidence": [ { "database": "UniProtKB", "id": "A6QLZ7", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7" } ], "pmid": "" }, { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "A6QLZ7", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 27, "end_pos": 29, "annotation": "n_glycosylation_sequon" }, { "start_pos": 450, "end_pos": 452, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QLZ7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 496, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QLZ7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QLZ7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A6QLZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7" }, { "id": "PRU00123", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00123" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LCCL 1", "eco_id": "ECO_0000255", "start_pos": 283, "end_pos": 378, "start_aa": "Met", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A6QLZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLZ7" }, { "id": "PRU00123", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00123" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LCCL 2", "eco_id": "ECO_0000255", "start_pos": 384, "end_pos": 487, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 27 ], "o_linked_sites": [ 265 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 27, "end_pos": 29 }, { "start_pos": 450, "end_pos": 452 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q58D06-1", "uniprot_ac": "Q58D06", "uniprot_id": "WDR74_BOVIN", "mass": { "chemical_mass": 42498.0, "monoisotopic_mass": 42498.0 }, "refseq": { "ac": "NP_001014854", "name": "WD repeat-containing protein 74", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014854" }, "gene_names": [ { "name": "WDR74", "type": "recommended", "evidence": [ { "id": "Q58D06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D06" } ] }, { "name": "WDR74", "type": "synonym", "evidence": [ { "id": "NP_001014854", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014854" } ] } ], "protein_names": [ { "name": "WD repeat-containing protein 74", "type": "recommended", "evidence": [ { "id": "Q58D06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D06/entry#names_and_taxonomy" } ] }, { "name": "WD repeat-containing protein 74", "type": "synonym", "evidence": [ { "id": "NP_001014854", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014854" } ] } ], "function": [ { "annotation": "Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit. Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL.", "evidence": [ { "database": "UniProtKB", "id": "Q58D06", "url": "https://www.uniprot.org/uniprotkb/Q58D06#function" }, { "database": "UniProtKB", "id": "Q6RFH5", "url": "https://www.uniprot.org/uniprotkb/Q6RFH5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58D06", "url": "https://www.uniprot.org/uniprotkb/Q58D06" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR74", "url": "https://www.uniprot.org/uniprotkb/Q58D06", "locus": { "chromosome": "29", "start_pos": 41141424, "end_pos": 41149376, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009491", "url": "https://www.ensembl.org/id/ENSBTAG00000009491" } ] } } ], "crossref": [ { "id": "Q58D06", "url": "https://alphafold.ebi.ac.uk/entry/Q58D06", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009491", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009491", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22857", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22857", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505875", "url": "https://www.ncbi.nlm.nih.gov/gene/505875", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037379", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037379", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505875", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505875", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KNVCRMR", "url": "https://omabrowser.org/oma/group/KNVCRMR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MXK0", "url": "https://www.orthodb.org/?gene=A0A3Q1MXK0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q58D06", "url": "https://www.orthodb.org/?gene=Q58D06", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16038", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16038", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16038:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16038:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014854", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MXK0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MXK0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXK0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9Z9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Z9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9Z9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Z9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YTR8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YTR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTR8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D06", "url": "https://www.uniprot.org/uniprotkb/Q58D06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D06-1", "url": "https://www.uniprot.org/uniprotkb/Q58D06-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAAARWNHVWVGTDTGILKGVNLQRKQAANFTASGQPRREEAVSALCWGAGGETQILVGCADGTVKHFSTEEGRFQGQRQCPGGEGTFRGLAQVDGTLITCVDSGILRVWTDKDKEASSDPVLELRVGPGVCRMRQDPARPHIVATGGKENALKVWDLQGSEEPLFRAKNVRNDWLDLRVPVWDQDIQFLPESQKLVTCTGYHQVRVYDPASPQRRPVLEATYGEYPLTAVTLTPEGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPRGLEHKVYLKSQLNCLLLSGRDNWEDEPQEPQEPNKVPSEDTETDELWASLEAAAKRKLPDWEQTQGALQARRRKKKRPGSTSS", "length": 385, "header": "sp|Q58D06-1|WDR74_BOVIN Isoform 1 of WD repeat-containing protein 74 OS=Bos taurus OX=9913 GN=WDR74 PE=2 SV=1 CANONICAL=Q58D06-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MXK0-1", "url": "https://www.uniprot.org/uniprotkb/Q58D06/entry#A0A3Q1MXK0-1", "sequence": { "sequence": "MAAAAARWNHVWVGTDTGILKGVNLQRKQAANFTASGQPRREEAVSALCWGAGGETQILVGCADGTVKHFSTEEGRFQGQRQCPGGEGTFRGLAQVDGFGGGGLRIWKVGPGVCRMRQDPARPHIVATGGKENALKVWDLQGSEEPLFRAKNVRNDWLDLRVPVWDQDIQFLPESQKLVTCTGYHQVRVYDPASPQRRPVLEATYGEYPLTAVTLTPEGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPRGLEHKVYLKSQLNCLLLSGRDNWEDEPQEPQEPNKVPSEDTETDELWASLEAAAKRKLPDWEQTQGALQARRRKKKRPGSTSS", "length": 365, "header": "tr|A0A3Q1MXK0-1|WDR74_BOVIN Computationally mapped isoform of WD repeat-containing protein 74 OS=Bos taurus OX=9913 GN=WDR74 PE=2 SV=1 CANONICAL=Q58D06-1" }, "locus": { "chromosome": "29", "start_pos": 41147676, "end_pos": 41141467, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071040.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071040.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060479.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060479.1" } ] } }, { "isoform_ac": "A0AAA9S9Z9-1", "url": "https://www.uniprot.org/uniprotkb/Q58D06/entry#A0AAA9S9Z9-1", "sequence": { "sequence": "MAAAAARWNHVWVGTDTGILKGVNLQRKQAANFTASGQPRREEAVSALCWGAGGETQILVGCADGTVKHFSTEEGRFQGQRQCPGGEGTFRGLAQVDGTLITCVDSGILRVWTDKDKEASSDPVLELRVGPGVCRMRQDPARPHIVATGGKENALKVWDLQGSEEPLFRAKNVRNDWLDLRVPVWDQDIQFLPESQKLVTCTGYHQVRVYDPASPQRRPVLEATYGEYPLTAVTLTPEGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPRGLEHKDEPQEPQEPNKVPSEDTETDELWASLEAAAKRKLPDWEQTQGALQARRRKKKRPGSTSS", "length": 366, "header": "tr|A0AAA9S9Z9-1|WDR74_BOVIN Computationally mapped isoform of WD repeat-containing protein 74 OS=Bos taurus OX=9913 GN=WDR74 PE=2 SV=1 CANONICAL=Q58D06-1" }, "locus": { "chromosome": "29", "start_pos": 41147676, "end_pos": 41141467, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115993.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115993.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078983.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078983.1" } ] } }, { "isoform_ac": "A0AAF6YTR8-1", "url": "https://www.uniprot.org/uniprotkb/Q58D06/entry#A0AAF6YTR8-1", "sequence": { "sequence": "MAAAAARWNHVWVGTDTGILKGVNLQRKQAANFTASGQPRREEAVSALCWGAGGETQILVGCADGTVKHFSTEEGRFQGQRQCPGGEGTFRGLAQVDGTLITCVDSGILRVWTDKDKEASSDPVLELRVGPGVCRMRQDPARPHIVATGGKENALKVWDLQGSEEPLFRAKNVRNDWLDLRVPVWDQDIQFLPESQKLVTCTGYHQVRVYDPASPQRRPVLEATYGEYPLTAVTLTPEGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPRGLEHKVPHLLQVYLKSQLNCLLLSGRDNWEDEPQEPQEPNKVPSEDTETDELWASLEAAAKRKLPDWEQTQGALQARRRKKKRPGSTSS", "length": 391, "header": "tr|A0AAF6YTR8-1|WDR74_BOVIN Computationally mapped isoform of WD repeat-containing protein 74 OS=Bos taurus OX=9913 GN=WDR74 PE=2 SV=1 CANONICAL=Q58D06-1" }, "locus": { "chromosome": "29", "start_pos": 41147676, "end_pos": 41141467, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012489.4", "url": "https://www.ensembl.org/id/ENSBTAT00000012489.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012489.3", "url": "https://www.ensembl.org/id/ENSBTAP00000012489.3" } ] } }, { "isoform_ac": "Q58D06-1", "url": "https://www.uniprot.org/uniprotkb/Q58D06/entry#Q58D06-1", "sequence": { "sequence": "MAAAAARWNHVWVGTDTGILKGVNLQRKQAANFTASGQPRREEAVSALCWGAGGETQILVGCADGTVKHFSTEEGRFQGQRQCPGGEGTFRGLAQVDGTLITCVDSGILRVWTDKDKEASSDPVLELRVGPGVCRMRQDPARPHIVATGGKENALKVWDLQGSEEPLFRAKNVRNDWLDLRVPVWDQDIQFLPESQKLVTCTGYHQVRVYDPASPQRRPVLEATYGEYPLTAVTLTPEGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPRGLEHKVYLKSQLNCLLLSGRDNWEDEPQEPQEPNKVPSEDTETDELWASLEAAAKRKLPDWEQTQGALQARRRKKKRPGSTSS", "length": 385, "header": "sp|Q58D06-1|WDR74_BOVIN Isoform 1 of WD repeat-containing protein 74 OS=Bos taurus OX=9913 GN=WDR74 PE=2 SV=1 CANONICAL=Q58D06-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 214, "end_pos": 214, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58D06", "url": "https://www.uniprot.org/uniprotkb/Q58D06" } ], "site_lbl": "Ser214" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58D06", "url": "https://www.uniprot.org/uniprotkb/Q58D06" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:505875", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505875", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3IHN4-1", "protein_name": "WD repeat-containing protein 74", "gene_name": "Wdr74", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAASSRGNHVWVGTDTGILKGVNLQRRHATNFTPSGQPRREEAVNALCWRAGDETQILVGCADMTVRHFNTEEGTFQSQRHCPGGEGTFRGLAQADGTLITCVDSGILRVWCDNDKEASSDPLLELKVGPGVCRMRQDPAHSHVVATCGKENALKVWDLQKPEQPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQKLVTCTGYHQVRVYDPVSPQRRPVLEATYGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRSPRGLEHKVYLKSQLNCLLLSGRDNWEDEPQEPQEPNMVPPEDTETDELWASLEANAKRKLPDLNQIQGTLQTRKKKKRPGSSSP", "length": 384 }, "evidence": [ { "id": "Q58D06", "url": "https://omabrowser.org/oma/group/Q58D06/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "M0RDY0-1", "protein_name": "WD repeat-containing protein 74", "gene_name": "Tex54", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAATSARWNHVWVGTETGILKGVNLQRKLAANFTPSGQPRREEAVNALCWGTGGETQILVGCADRTVRHFNAEEGTFQSQRYCPGGEGTFRGLAQADDGTLITCVDSGILRVWCENDKEASSDPLLELKVGPGVCRMRQDPTHTHVVATCGKENALKVWDLQGSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQKLVTCTGYHQVRIYDPASPQRRPVLEATYGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPRGLEHKVYLKSQLNCLLLSGRDNWEDEPQEPQEPNLVPPEDTETDELWASLEAAAKRKLPDLDQKQGALQRRKKKKRPGSTSP", "length": 385 }, "evidence": [ { "id": "Q58D06", "url": "https://omabrowser.org/oma/group/Q58D06/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6RFH5-1", "protein_name": "WD repeat-containing protein 74", "gene_name": "WDR74", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAAARWNHVWVGTETGILKGVNLQRKQAANFTAGGQPRREEAVSALCWGTGGETQMLVGCADRTVKHFSTEDGIFQGQRHCPGGEGMFRGLAQADGTLITCVDSGILRVWHDKDKDTSSDPLLELRVGPGVCRMRQDPAHPHVVATGGKENALKIWDLQGSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPRGLEHKVYLKSQLNCLLLSGRDNWEDEPQEPQEPNKVPLEDTETDELWASLEAAAKRKLSGLEQPQGALQTRRRKKKRPGSTSP", "length": 385 }, "evidence": [ { "id": "Q58D06", "url": "https://omabrowser.org/oma/group/Q58D06/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VCG3-1", "protein_name": "WD repeat-containing protein 74", "gene_name": "Wdr74", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATASARWNHVWVGTETGILKGVNLQRKHAANFTPSGQPRREEAVNALCWGTGGETQILVGCADRTVRYFNAEEGTFLSQRYCPGGEGTFRGLAQADGTLITCVDSGILRVWCENDKEASSDPLLELKVGPGVCRMRQDPTHTHVVATCGKENALKVWDLQGSEEPVFRAKNVRNDWLDLRVPIWDQDTQFLPGSQKLVTCTGYHQVRVYDPVSPQRRPVLEATYGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPRGLEHKVYLKSQLNCLLLSGRDNWEDEPQEPQEPNQVPSEDTETDELWASLEAAAKRKLPDLDQTQGALQRRKKKKRPGSTSP", "length": 384 }, "evidence": [ { "id": "Q58D06", "url": "https://omabrowser.org/oma/group/Q58D06/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q58D06", "url": "https://www.uniprot.org/uniprotkb/Q58D06" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q58D06", "url": "https://www.uniprot.org/uniprotkb/Q58D06" } ], "pmid": "" }, { "name": "preribosome, large subunit precursor", "id": "GO:0030687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030687", "evidence": [ { "database": "UniProtKB", "id": "Q58D06", "url": "https://www.uniprot.org/uniprotkb/Q58D06" } ], "pmid": "" }, { "name": "nuclear exosome (RNase complex)", "id": "GO:0000176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000176", "evidence": [ { "database": "UniProtKB", "id": "Q58D06", "url": "https://www.uniprot.org/uniprotkb/Q58D06" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "ribosomal large subunit biogenesis", "id": "GO:0042273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042273", "evidence": [ { "database": "UniProtKB", "id": "Q58D06", "url": "https://www.uniprot.org/uniprotkb/Q58D06" } ], "pmid": "" }, { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "Q58D06", "url": "https://www.uniprot.org/uniprotkb/Q58D06" } ], "pmid": "" }, { "name": "RNA metabolic process", "id": "GO:0016070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016070", "evidence": [ { "database": "UniProtKB", "id": "Q58D06", "url": "https://www.uniprot.org/uniprotkb/Q58D06" } ], "pmid": "" }, { "name": "blastocyst formation", "id": "GO:0001825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001825", "evidence": [ { "database": "UniProtKB", "id": "Q58D06", "url": "https://www.uniprot.org/uniprotkb/Q58D06" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 32, "end_pos": 34, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58D06-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 385, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58D06-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58D06" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 214 ], "sequon_annotation_sites": [ { "start_pos": 32, "end_pos": 34 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "A6QLD5-1", "uniprot_ac": "A6QLD5", "uniprot_id": "F124B_BOVIN", "mass": { "chemical_mass": 51630.0, "monoisotopic_mass": 51630.0 }, "refseq": { "ac": "NP_001095340", "name": "protein FAM124B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095340" }, "gene_names": [ { "name": "FAM124B", "type": "recommended", "evidence": [ { "id": "A6QLD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLD5" } ] }, { "name": "FAM124B", "type": "synonym", "evidence": [ { "id": "NP_001095340", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095340" } ] } ], "protein_names": [ { "name": "Protein FAM124B", "type": "recommended", "evidence": [ { "id": "A6QLD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLD5/entry#names_and_taxonomy" } ] }, { "name": "family with sequence similarity 124B", "type": "synonym", "evidence": [ { "id": "NP_001095340", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095340" } ] }, { "name": "protein FAM124B", "type": "synonym", "evidence": [ { "id": "NP_001095340", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095340" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QLD5", "url": "https://www.uniprot.org/uniprotkb/A6QLD5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM124B", "url": "https://www.uniprot.org/uniprotkb/A6QLD5", "locus": { "chromosome": "2", "start_pos": 112489097, "end_pos": 112515653, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038700", "url": "https://www.ensembl.org/id/ENSBTAG00000038700" } ] } } ], "crossref": [ { "id": "A6QLD5", "url": "https://alphafold.ebi.ac.uk/entry/A6QLD5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038700", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038700", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506367", "url": "https://www.ncbi.nlm.nih.gov/gene/506367", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029380", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029380", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506367", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506367", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DIJ7", "url": "https://www.orthodb.org/?gene=A0A452DIJ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A6QLD5", "url": "https://www.orthodb.org/?gene=A6QLD5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14715", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14715", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14715:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14715:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15067", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15067", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9943962", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9943962", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001095340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095340", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DIJ7", "url": "https://www.uniprot.org/uniprotkb/A0A452DIJ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIJ7-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIJ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA98-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDR1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDR1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDR1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QLD5", "url": "https://www.uniprot.org/uniprotkb/A6QLD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QLD5-1", "url": "https://www.uniprot.org/uniprotkb/A6QLD5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDEMPEPPAMTVHLLANAGQGLLLQQTLDQLLDCICPDIRLFLVSERASPVKYYDKCHSKRSRFPGMSVLLFLKENLGEERLFHVLDSLQHWPWQCYPTQNAQGRPCPYILANQEFYSLDSQMPIWGVRQVHCGTEILRVTLYCSFDNYEDAIRLYAMILQREATLQKSNFCFFVLYSTETFALQLSLKQLPLGTSVDPKEASVLQFKVQEIGQLVPLLPHPCVPISRTRWQTQDYDGNKILLQVQLNPGLGVRNGEPPFLNGTLGADTLPHGSRLTPVSAIRTLELRSRRIRGRRFKVSSVELPEPGGRPVSDGSSNTWWKSAGGSAQPSSPATESQPQLSSLHLEPGARMKVLGRENSFEKLEAETNVDTGFTMVSSEPRPSFASRFPRNLQTHQPPSCLSTSFSGSAASKNNRIFKERVHPLPLAGQRDLGAKKILSKCPLPLPVQGEAKEAEEEFFI", "length": 461, "header": "sp|A6QLD5-1|F124B_BOVIN Isoform 1 of Protein FAM124B OS=Bos taurus OX=9913 GN=FAM124B PE=2 SV=1 CANONICAL=A6QLD5-1" }, "isoforms": [ { "isoform_ac": "A0A452DIJ7-1", "url": "https://www.uniprot.org/uniprotkb/A6QLD5/entry#A0A452DIJ7-1", "sequence": { "sequence": "MFYIIHRLDDMDPAAGVCCMEAVVPESVEIRLQCGQQQPGIQEAGPAGPIRQHPLSSSAPTMDEMPEPPAMTVHLLANAGQGLLLQQTLDQLLDCICPDIRLFLVSERASPVKYYDKCHSKRSRFPGMSVLLFLKENLGEERLFHVLDSLQHWPWQCYPTQNAQGRPCPYILANQEFYSLDSQMPIWGVRQVHCGTEILRVTLYCSFDNYEDAIRLYAMILQREATLQKSNFCFFVLYSTETFALQLSLKQLPLGTSVDPKEASVLQFKVQEIGQLVPLLPHPCVPISRTRWQTQDYDGNKILLQVQLNPGLGVRNGEPPFLNGTLGADTLPHGSRLTPVSAIRTLELRSRRIRGRRFKVSSVELPEPGGRPVSDGSSNTWWKSAGGSAQPSSPATESQPQLSSLHLEPGARMKVLGWENSFEKLEAETNVDTGFTMVSSEPRPSFASRFPRNLQTHQPPSCLSTSFSGSAASKNNRIFKERVHPLPLAGQRDLGAKKILSKCPLPLPVQGEAKEAEEEFFI", "length": 522, "header": "tr|A0A452DIJ7-1|F124B_BOVIN Computationally mapped isoform of Protein FAM124B OS=Bos taurus OX=9913 GN=FAM124B PE=2 SV=2 CANONICAL=A6QLD5-1" }, "locus": { "chromosome": "2", "start_pos": 112505906, "end_pos": 112491235, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015633.8", "url": "https://www.ensembl.org/id/ENSBTAT00000015633.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015633.7", "url": "https://www.ensembl.org/id/ENSBTAP00000015633.7" } ] } }, { "isoform_ac": "A0AAA9SA98-1", "url": "https://www.uniprot.org/uniprotkb/A6QLD5/entry#A0AAA9SA98-1", "sequence": { "sequence": "MDPAAGVCCMEAVVPESVEIRLQCGQQQPGIQEAGPAGPIRQHPLSSSAPTMDEMPEPPAMTVHLLANAGQGLLLQQTLDQLLDCICPDIRLFLVSERASPVKYYDKCHSKRSRFPGMSVLLFLKENLGEERLFHVLDSLQHWPWQCYPTQNAQGRPCPYILANQEFYSLDSQMPIWGVRQVHCGTEILRVTLYCSFDNYEDAIRLYAMILQREATLQKSNFCFFVLYSTETFALQLSLKQLPLGTSVDPKEASVLQFKVQEIGQLVPLLPHPCVPISRTRWQTQDYDGNKILLQVQLNPGLGVRNGEPPFLNGTLGADTLPHGSRLTPVSAIRTLELRSRRIRGRRFKVSSVELPEPGGRPVSDGSSNTWWKSAGGSAQPSSPATESQPQLSSLHLEPGARMKVLGWENSFEKLEAETNVDTGFTMVSSEPRPSFASRFPRNLQTHQPPSCLSTSFSGSAASKNNRIFKERVHPLPLAGQRDLGAKKILSKCPLPLPVQGEAKEAEEEFFI", "length": 512, "header": "tr|A0AAA9SA98-1|F124B_BOVIN Computationally mapped isoform of Protein FAM124B OS=Bos taurus OX=9913 GN=FAM124B PE=2 SV=1 CANONICAL=A6QLD5-1" }, "locus": { "chromosome": "2", "start_pos": 112502170, "end_pos": 112491235, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121548.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121548.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082257.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082257.1" } ] } }, { "isoform_ac": "A0AAA9SDR1-1", "url": "https://www.uniprot.org/uniprotkb/A6QLD5/entry#A0AAA9SDR1-1", "sequence": { "sequence": "MTLLNSYIIHRLDDMDPAAGVCCMEAVVPESVEIRLQCGQQQPGIQEAGPAGPIRQHPLSSSAPTMDEMPEPPAMTVHLLANAGQGLLLQQTLDQLLDCICPDIRLFLVSERASPVKYYDKCHSKRSRFPGMSVLLFLKENLGEERLFHVLDSLQHWPWQCYPTQNAQGRPCPYILANQEFYSLDSQMPIWGVRQVHCGTEILRVTLYCSFDNYEDAIRLYAMILQREATLQKSNFCFFVLYSTETFALQLSLKQLPLGTSVDPKEASVLQFKVQEIGQLVPLLPHPCVPISRTRWQTQDYDGNKILLQVQLNPGLGVRNGEPPFLNGTLGADTLPHGSRLTPVSAIRTLELRSRRIRGRRFKVSSVELPEPGGRPVSDGSSNTWWKSAGGSAQPSSPATESQPQLSSLHLEPGARMKVLGWENSFEKLEAETNVDTGFTMVSSEPRPSFASRFPRNLQTHQPPSCLSTSFSGSAASKNNRIFKERVHPLPLAGQRDLGAKKILSKCPLPLPVQGEAKEAEEEFFI", "length": 526, "header": "tr|A0AAA9SDR1-1|F124B_BOVIN Computationally mapped isoform of Protein FAM124B OS=Bos taurus OX=9913 GN=FAM124B PE=2 SV=1 CANONICAL=A6QLD5-1" }, "locus": { "chromosome": "2", "start_pos": 112515350, "end_pos": 112491235, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112986.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112986.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083535.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083535.1" } ] } }, { "isoform_ac": "A0AAA9SLM5-1", "url": "https://www.uniprot.org/uniprotkb/A6QLD5/entry#A0AAA9SLM5-1", "sequence": { "sequence": "MSDSLDPMDYTVYGILQARILDYIIHRLDDMDPAAGVCCMEAVVPESVEIRLQCGQQQPGIQEAGPAGPIRQHPLSSSAPTMDEMPEPPAMTVHLLANAGQGLLLQQTLDQLLDCICPDIRLFLVSERASPVKYYDKCHSKRSRFPGMSVLLFLKENLGEERLFHVLDSLQHWPWQCYPTQNAQGRPCPYILANQEFYSLDSQMPIWGVRQVHCGTEILRVTLYCSFDNYEDAIRLYAMILQREATLQKSNFCFFVLYSTETFALQLSLKQLPLGTSVDPKEASVLQFKVQEIGQLVPLLPHPCVPISRTRWQTQDYDGNKILLQVQLNPGLGVRNGEPPFLNGTLGADTLPHGSRLTPVSAIRTLELRSRRIRGRRFKVSSVELPEPGGRPVSDGSSNTWWKSAGGSAQPSSPATESQPQLSSLHLEPGARMKVLGWENSFEKLEAETNVDTGFTMVSSEPRPSFASRFPRNLQTHQPPSCLSTSFSGSAASKNNRIFKERVHPLPLAGQRDLGAKKILSKCPLPLPVQGEAKEAEEEFFI", "length": 542, "header": "tr|A0AAA9SLM5-1|F124B_BOVIN Computationally mapped isoform of Protein FAM124B OS=Bos taurus OX=9913 GN=FAM124B PE=2 SV=1 CANONICAL=A6QLD5-1" }, "locus": { "chromosome": "2", "start_pos": 112503587, "end_pos": 112491235, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109030.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109030.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084820.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084820.1" } ] } }, { "isoform_ac": "A6QLD5-1", "url": "https://www.uniprot.org/uniprotkb/A6QLD5/entry#A6QLD5-1", "sequence": { "sequence": "MDEMPEPPAMTVHLLANAGQGLLLQQTLDQLLDCICPDIRLFLVSERASPVKYYDKCHSKRSRFPGMSVLLFLKENLGEERLFHVLDSLQHWPWQCYPTQNAQGRPCPYILANQEFYSLDSQMPIWGVRQVHCGTEILRVTLYCSFDNYEDAIRLYAMILQREATLQKSNFCFFVLYSTETFALQLSLKQLPLGTSVDPKEASVLQFKVQEIGQLVPLLPHPCVPISRTRWQTQDYDGNKILLQVQLNPGLGVRNGEPPFLNGTLGADTLPHGSRLTPVSAIRTLELRSRRIRGRRFKVSSVELPEPGGRPVSDGSSNTWWKSAGGSAQPSSPATESQPQLSSLHLEPGARMKVLGRENSFEKLEAETNVDTGFTMVSSEPRPSFASRFPRNLQTHQPPSCLSTSFSGSAASKNNRIFKERVHPLPLAGQRDLGAKKILSKCPLPLPVQGEAKEAEEEFFI", "length": 461, "header": "sp|A6QLD5-1|F124B_BOVIN Isoform 1 of Protein FAM124B OS=Bos taurus OX=9913 GN=FAM124B PE=2 SV=1 CANONICAL=A6QLD5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 49, "end_pos": 49, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QLD5", "url": "https://www.uniprot.org/uniprotkb/A6QLD5" } ], "site_lbl": "Ser49" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506367", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506367", "resource": "KEGG Pathway" }, { "id": "R-BTA-9943962", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9943962", "resource": "Reactome", "description": "CHD6, CHD7, CHD8, CHD9 subfamily" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A6QLD5", "url": "https://www.uniprot.org/uniprotkb/A6QLD5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 262, "end_pos": 264, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QLD5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 461, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QLD5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QLD5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 49 ], "sequon_annotation_sites": [ { "start_pos": 262, "end_pos": 264 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", 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"sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q5E9Q4-1", "uniprot_ac": "Q5E9Q4", "uniprot_id": "NECP2_BOVIN", "mass": { "chemical_mass": 28551.0, "monoisotopic_mass": 28551.0 }, "refseq": { "ac": "NP_001015562", "name": "adaptin ear-binding coat-associated protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015562" }, "gene_names": [ { "name": "NECAP2", "type": "recommended", "evidence": [ { "id": "Q5E9Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q4" } ] }, { "name": "NECAP2", "type": "synonym", "evidence": [ { "id": "NP_001015562", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015562" } ] } ], "protein_names": [ { "name": "Adaptin ear-binding coat-associated protein 2", "type": "recommended", "evidence": [ { "id": "Q5E9Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q4/entry#names_and_taxonomy" } ] }, { "name": "NECAP endocytosis-associated protein 2", "type": 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"database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8856828", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015562", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015562", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LK58", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LK58", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LK58-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LK58-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJD5", "url": "https://www.uniprot.org/uniprotkb/A0A452DJD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJD5-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJD5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU10", "database": "UniProtKB", 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"https://www.uniprot.org/uniprotkb/Q5E9Q4/entry#A0A3Q1LK58-1", "sequence": { "sequence": "MEEAEYESVLCVKPDVHVYRIPPRATNRGYRAAEWQLDQPSWSGRLRITAKGQVAYIKLEDRTSGELFAQAPVDQFPGTAVESVTDSSRYFVIRIEDGNGRRAFIGIGFGDRGDAFDFNVALQDHFKWVKQQCEFAKQAQNPDQGPKLDLSFKEGQTIKLNIASMKKKDGAAGTPRTRPTSTGGLSLLPPPPGAKTAALAPLSGEHLSVGGSVVQPAVSPSSGGATVSWPQPKPATTATADIWGDFTKSTGTSGEEPPRRG", "length": 261, "header": "tr|A0A3Q1LK58-1|NECP2_BOVIN Computationally mapped isoform of Adaptin ear-binding coat-associated protein 2 OS=Bos taurus OX=9913 GN=NECAP2 PE=2 SV=2 CANONICAL=Q5E9Q4-1" }, "locus": { "chromosome": "2", "start_pos": 135688416, "end_pos": 135675562, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072817.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072817.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059916.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059916.2" } ] } }, { "isoform_ac": "A0A452DJD5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q4/entry#A0A452DJD5-1", "sequence": { "sequence": "MEEAEYESVLCVKPDVHVYRIPPRATNRGYRAAEWQLDQPSWSGRLRITAKGQVAYIKLEDRTSGELFAQAPVDQFPGTAVESVTDSSRYFVIRIEDGNGRRAFIGIGFGDRGDAFDFNVALQDHFKWVKQQCEFAKQAQNPDQGPKLDLSFKEGQTIKLNIASMKKKDGAAGTPRTRPTSTGGLSLLPPPPGAKTAALAPLSGEHLSVGGSVVQPAVSPSSGRPPARLSQAQAGFSSDLDVTLFLIGLLERSRLVGAEGRSMRCSLASLCWEHESLLSSSLPGSLNRLGVLGGTLAPCHTVAWDSNLQPEHGRRVSGSLPPSVLLT", "length": 327, "header": "tr|A0A452DJD5-1|NECP2_BOVIN Computationally mapped isoform of Adaptin ear-binding coat-associated protein 2 OS=Bos taurus OX=9913 GN=NECAP2 PE=2 SV=2 CANONICAL=Q5E9Q4-1" }, "locus": { "chromosome": "2", "start_pos": 135688416, "end_pos": 135675354, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017663.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017663.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017663.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017663.6" } ] } }, { "isoform_ac": "A0AAA9SU10-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q4/entry#A0AAA9SU10-1", "sequence": { "sequence": "MEEAEYESVLCVKPDVHVYRIPPRATNRGYRGALCSGPSGSVSRHSCGERDGFQQVLRYPHRRWKRWVKQQCEFAKQAQNPDQGPKLDLSFKEGQTIKLNIASMKKKDGAAGTPRTRPTSTGGLSLLPPPPGAKTAALAPLSGEHLSVGGSVVQPAVSPSSGGATVSWPQPKPATTATADIWGDFTKSTGSTSSQTQPGAGWVQF", "length": 205, "header": "tr|A0AAA9SU10-1|NECP2_BOVIN Computationally mapped isoform of Adaptin ear-binding coat-associated protein 2 OS=Bos taurus OX=9913 GN=NECAP2 PE=2 SV=1 CANONICAL=Q5E9Q4-1" }, "locus": { "chromosome": "2", "start_pos": 135688416, "end_pos": 135675622, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122678.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122678.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088823.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088823.1" } ] } }, { "isoform_ac": "Q5E9Q4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q4/entry#Q5E9Q4-1", "sequence": { "sequence": "MEEAEYESVLCVKPDVHVYRIPPRATNRGYRAAEWQLDQPSWSGRLRITAKGQVAYIKLEDRTSGELFAQAPVDQFPGTAVESVTDSSRYFVIRIEDGNGRRAFIGIGFGDRGDAFDFNVALQDHFKWVKQQCEFAKQAQNPDQGPKLDLSFKEGQTIKLNIASMKKKDGAAGTPRARPTSTGGLSLLPPPPGAKTAALAPLSGEHLSVGGSVVQPAVSPSSGGATVSWPQPKPATTATADIWGDFTKSTGSTSSQTQPGAGWVQF", "length": 266, "header": "sp|Q5E9Q4-1|NECP2_BOVIN Isoform 1 of Adaptin ear-binding coat-associated protein 2 OS=Bos taurus OX=9913 GN=NECAP2 PE=2 SV=1 CANONICAL=Q5E9Q4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 181, "end_pos": 181, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q4", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q4" } ], "site_lbl": "Ser181" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q4", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:509439", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509439", "resource": "KEGG Pathway" }, { "id": "R-BTA-8856825", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "resource": "Reactome", "description": "Cargo recognition for clathrin-mediated endocytosis" }, { "id": "R-BTA-8856828", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "resource": "Reactome", "description": "Clathrin-mediated endocytosis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "clathrin vesicle coat", "id": "GO:0030125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030125", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q4", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q4", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q4", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q4" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q4", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q4" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q4", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9Q4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 266, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9Q4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9Q4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 181 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9U0-1", "uniprot_ac": "Q5E9U0", "uniprot_id": "SP2_BOVIN", "mass": { "chemical_mass": 64718.0, "monoisotopic_mass": 64718.0 }, "refseq": { "ac": "NP_001421977", "name": "transcription factor Sp2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421977" }, "gene_names": [ { "name": "SP2", "type": "recommended", "evidence": [ { "id": "Q5E9U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9U0" } ] }, { "name": "SP2", "type": "synonym", "evidence": [ { "id": "NP_001421977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421977" } ] } ], "protein_names": [ { "name": "Transcription factor Sp2", "type": "recommended", "evidence": [ { "id": "Q5E9U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9U0/entry#names_and_taxonomy" } ] }, { "name": "transcription factor Sp2", "type": "synonym", "evidence": [ { "id": "NP_001421977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421977" } ] } ], "function": [ { "annotation": "Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U0", "url": "https://www.uniprot.org/uniprotkb/Q5E9U0#function" }, { "database": "UniProtKB", "id": "A0AAA9S416", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S416#function" }, { "database": "UniProtKB", "id": "ARBA00056082", "url": "https://www.uniprot.org/uniprotkb/ARBA00056082#function" }, { "database": "UniProtKB", "id": "A0A452DJJ4", "url": "https://www.uniprot.org/uniprotkb/A0A452DJJ4#function" }, { "database": "UniProtKB", "id": "A0AAA9S4T0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4T0#function" }, { "database": "UniProtKB", "id": "A0AAA9S5L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L6#function" }, { "database": "UniProtKB", "id": "A0AAA9TH88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH88#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9U0", "url": "https://www.uniprot.org/uniprotkb/Q5E9U0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SP2", "url": "https://www.uniprot.org/uniprotkb/Q5E9U0", "locus": { "chromosome": "19", "start_pos": 38533720, "end_pos": 38565125, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013740", "url": "https://www.ensembl.org/id/ENSBTAG00000013740" } ] } } ], "crossref": [ { "id": "Q5E9U0", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9U0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013740", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013740", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22540", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22540", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534403", "url": "https://www.ncbi.nlm.nih.gov/gene/534403", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534403", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534403", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DJJ4", "url": "https://www.orthodb.org/?gene=A0A452DJJ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5E9U0", "url": "https://www.orthodb.org/?gene=Q5E9U0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001421977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421977", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DJJ4", "url": "https://www.uniprot.org/uniprotkb/A0A452DJJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S416", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S416", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S416-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S416-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4T0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4T0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4T0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4T0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5L6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH88-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9U0", "url": "https://www.uniprot.org/uniprotkb/Q5E9U0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9U0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9U0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDPQTSMAATAAVSPSDYLQPAASTTQDSQPSPLALLAATCSKIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPSKNSFGILSSKGNILQIQGSQLSTSYPGGQLVFAIQNPTVVNKGTRSNTSIQYQAVPQIQASSPQTIQVQPSLTNQIQIIPGTNQAIITPSPSSHKPVPIKPAPVQKSSTTTTPAQSGANVVKLTGGGGNVTLTLPVNNLVNTSDPGAATQLLTESPPAPLSKTNKKARKKSLPAAQPPVAVAEQVETVLIETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQAAEPSPTQVYIRTPSGEVQTVLVQDSPPATAATASTTTCSSPASRAAHLSGTSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVPVTITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGETQPGEKRRRMACTCPNCKDGDKRSGEQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTKHYKTHLVTKNL", "length": 613, "header": "sp|Q5E9U0-1|SP2_BOVIN Isoform 1 of Transcription factor Sp2 OS=Bos taurus OX=9913 GN=SP2 PE=2 SV=1 CANONICAL=Q5E9U0-1" }, "isoforms": [ { "isoform_ac": "A0A452DJJ4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9U0/entry#A0A452DJJ4-1", "sequence": { "sequence": "MRPDSQPSPLALLAATCSKIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPSKNSFGILSSKGNILQIQGSQLSTSYPGGQLVFAIQNPTVVNKGTRSNTSIQYQAVPQIQASSPQTIQVQPSLTNQIQIIPGTNQAIITPSPSSHKPVPIKPAPVQKSSTTTTPAQSGANVVKLTGGGGNVTLTLPVNNLVNTSDPGAATQLLTESPPAPLSKTNKKARKKSLPAAQPPVAVAEQVETVLIETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQAAEPSPTQVYIRTPSGEVQTVLVQDSPPATAATASTTTCSSPASRAAHLSGTSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVPVTITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGETQPGEKRRRMACTCPNCKDGDKRSGEQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTKHYKTHLVTKNL", "length": 588, "header": "tr|A0A452DJJ4-1|SP2_BOVIN Computationally mapped isoform of Transcription factor Sp2 OS=Bos taurus OX=9913 GN=SP2 PE=2 SV=2 CANONICAL=Q5E9U0-1" }, "locus": { "chromosome": "19", "start_pos": 38544963, "end_pos": 38534846, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064585.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064585.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054632.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054632.3" } ] } }, { "isoform_ac": "A0AAA9S416-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9U0/entry#A0AAA9S416-1", "sequence": { "sequence": "RIHRPAWLPLPLSVPVTTCSLPPLPPSGETTGDGETGTTAGEGCWHPTRQDSQPSPLALLAATCSKIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPSKNSFGILSSKGNILQIQGSQLSTSYPGGQLVFAIQNPTVVNKGTRSNTSIQYQAVPQIQASSPQTIQVQPSLTNQIQIIPGTNQAIITPSPSSHKPVPIKPAPVQKSSTTTTPAQSGANVVKLTGGGGNVTLTLPVNNLVNTSDPGAATQLLTESPPAPLSKTNKKARKKSLPAAQPPVAVAEQVETVLIETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQAAEPSPTQVYIRTPSGEVQTVLVQDSPPATAATASTTTCSSPASRAAHLSGTSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVPVTITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGETQPGEKRRRMACTCPNCKDGDKRSGEQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTKHYKTHLVTKNL", "length": 635, "header": "tr|A0AAA9S416-1|SP2_BOVIN Computationally mapped isoform of Transcription factor Sp2 OS=Bos taurus OX=9913 GN=SP2 PE=2 SV=1 CANONICAL=Q5E9U0-1" }, "locus": { "chromosome": "19", "start_pos": 38550313, "end_pos": 38534846, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120358.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120358.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079850.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079850.1" } ] } }, { "isoform_ac": "A0AAA9S4T0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9U0/entry#A0AAA9S4T0-1", "sequence": { "sequence": "MERSPSDFSVHGIFQARILEWVAIFFSRGSCRLSDRTCVSCIPGRFFSTEPPGKPGLDPQTSMAATAAVSPSDYLQPAASTTQDSQPSPLALLAATCSKIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPSKNSFGILSSKGNILQIQGSQLSTSYPGGQLVFAIQNPTVVNKGTRSNTSIQYQAVPQIQASSPQTIQVQPSLTNQIQIIPGTNQAIITPSPSSHKPVPIKPAPVQKSSTTTTPAQSGANVVKLTGGGGNVTLTLPVNNLVNTSDPGAATQLLTESPPAPLSKTNKKARKKSLPAAQPPVAVAEQVETVLIETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQAAEPSPTQVYIRTPSGEVQTVLVQDSPPATAATASTTTCSSPASRAAHLSGTSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVPVTITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGETQPGEKRRRMACTCPNCKDGDKRSGEQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTKHYKTHLVTKNL", "length": 668, "header": "tr|A0AAA9S4T0-1|SP2_BOVIN Computationally mapped isoform of Transcription factor Sp2 OS=Bos taurus OX=9913 GN=SP2 PE=2 SV=1 CANONICAL=Q5E9U0-1" }, "locus": { "chromosome": "19", "start_pos": 38555839, "end_pos": 38534846, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097132.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097132.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078844.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078844.1" } ] } }, { "isoform_ac": "A0AAA9S5L6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9U0/entry#A0AAA9S5L6-1", "sequence": { "sequence": "ADSQPSPLALLAATCSKIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPSKNSFGILSSKGNILQIQGSQLSTSYPGGQLVFAIQNPTVVNKGTRSNTSIQYQAVPQIQASSPQTIQVQPSLTNQIQIIPGTNQAIITPSPSSHKPVPIKPAPVQKSSTTTTPAQSGANVVKLTGGGGNVTLTLPVNNLVNTSDPGAATQLLTESPPAPLSKTNKKARKKSLPAAQPPVAVAEQVETVLIETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQAAEPSPTQVYIRTPSGEVQTVLVQDSPPATAATASTTTCSSPASRAAHLSGTSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVPVTITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGETQPGEKRRRMACTCPNCKDGDKRSGEQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTKHYKTHLVTKNL", "length": 586, "header": "tr|A0AAA9S5L6-1|SP2_BOVIN Computationally mapped isoform of Transcription factor Sp2 OS=Bos taurus OX=9913 GN=SP2 PE=2 SV=1 CANONICAL=Q5E9U0-1" }, "locus": { "chromosome": "19", "start_pos": 38565026, "end_pos": 38534846, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127782.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127782.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081212.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081212.1" } ] } }, { "isoform_ac": "A0AAA9TH88-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9U0/entry#A0AAA9TH88-1", "sequence": { "sequence": 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"https://www.ensembl.org/id/ENSBTAT00000100095.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097605.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097605.1" } ] } }, { "isoform_ac": "Q5E9U0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9U0/entry#Q5E9U0-1", "sequence": { "sequence": "MSDPQTSMAATAAVSPSDYLQPAASTTQDSQPSPLALLAATCSKIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPSKNSFGILSSKGNILQIQGSQLSTSYPGGQLVFAIQNPTVVNKGTRSNTSIQYQAVPQIQASSPQTIQVQPSLTNQIQIIPGTNQAIITPSPSSHKPVPIKPAPVQKSSTTTTPAQSGANVVKLTGGGGNVTLTLPVNNLVNTSDPGAATQLLTESPPAPLSKTNKKARKKSLPAAQPPVAVAEQVETVLIETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQAAEPSPTQVYIRTPSGEVQTVLVQDSPPATAATASTTTCSSPASRAAHLSGTSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVPVTITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGETQPGEKRRRMACTCPNCKDGDKRSGEQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTKHYKTHLVTKNL", "length": 613, "header": "sp|Q5E9U0-1|SP2_BOVIN Isoform 1 of Transcription factor Sp2 OS=Bos taurus OX=9913 GN=SP2 PE=2 SV=1 CANONICAL=Q5E9U0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 63, "start_aa": "Thr", "end_pos": 63, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr63", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 78, "end_pos": 78, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U0", "url": "https://www.uniprot.org/uniprotkb/Q5E9U0" } ], "site_lbl": "Ser78" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U0", "url": "https://www.uniprot.org/uniprotkb/Q5E9U0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:534403", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534403", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U0", "url": "https://www.uniprot.org/uniprotkb/Q5E9U0" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U0", "url": "https://www.uniprot.org/uniprotkb/Q5E9U0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U0", "url": "https://www.uniprot.org/uniprotkb/Q5E9U0" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U0", "url": "https://www.uniprot.org/uniprotkb/Q5E9U0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": 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"UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJZ0", "url": "https://www.uniprot.org/uniprotkb/A0A452DJZ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJZ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJZ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RU49", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RU49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RU49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RU49-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAF8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAF8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAF8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TR65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TR65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA45", "url": "https://www.uniprot.org/uniprotkb/Q5EA45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA45-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA45-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA45-2", "url": "https://www.uniprot.org/uniprotkb/Q5EA45-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRRALRLRLGPCLSGRGLGTYRRGSTLDWDGKVSEIKKKIQSIFPGGAWNPLYDTSHLPPERSDVVIVGGGVLGLSVAYWLKRLEKQQGAIRVLVVERDHTYARASTVLSVGGIRQQFSLPQNVQLSLFSAEFLRNINEYLAVVDDPPLDLQFNPSGYLLLASEEGAAIMERNVKMQRQEGAKVCLMSPEQLQKKFPWINTEGVALASYGLENEGWFDPWCLLQGLRRKLQSMGVLFCQGEVTRFISSSSHMETASGEQLTLKRIHEVHVKMDHSQEFQPVECAIVVNAAGAWSGQIAELAGVGNGPPGTMQGTKLPVEPRKRYVYLWHCPQGPGLEAPLVADPSGAYFRREGLGNNYVGSCSPTEEEEPDPGNLEVDYDFFQEKVWPRLAQRVPAFETLKVRSAWAGYYDYNTFDQNGVVGPHPLVVNMYFATGFSGHGLQQAPAVGRAVAEMVLEGHFQTINLSPFLFSRFYFGEKAQEHCIL", "length": 486, "header": "sp|Q5EA45-1|FXRD1_BOVIN Isoform 1 of FAD-dependent oxidoreductase domain-containing protein 1 OS=Bos taurus OX=9913 GN=FOXRED1 PE=2 SV=1 CANONICAL=Q5EA45-1" }, "isoforms": [ { "isoform_ac": "A0A452DJL0-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA45/entry#A0A452DJL0-1", "sequence": { "sequence": "MLRRALRLRLGPCLSGRGLGTYRRGSTLDWDGKVSEIKKKIQSIFPGGAWNPLYDTSHLPPERSDVVIVGGVLGLSVAYWLKRLEKQQGAIRVLVVERDHTYARASTVLSVGGIRQQFSLPQNVQLSLFSAEFLRNINEYLAVVDDPPLDLQFNPSGYLLLASEEGAAIMERNVKMQRQEGAKVCLMSPEQLQKKFPWINTEGVALASYGLENEGWFDPWCLLQGLRRKLQSMGVLFCQGEVTRFISSSSHMETASGEQLTLKRIHEVHVKMDHSQEFQPVECAIVVNAAGAWSGQIAELAGVGNGPPGTMQGTKLPVEPRKRYVYLWHCPQGPGLEAPLVADPSGAYFRREGLGNNYVGSCSEEEPDPGNLEVDYDFFQEKVWPRLAQRVPAFETLKVTDR", "length": 402, "header": "tr|A0A452DJL0-1|FXRD1_BOVIN Computationally mapped isoform of FAD-dependent oxidoreductase domain-containing protein 1 OS=Bos taurus OX=9913 GN=FOXRED1 PE=2 SV=2 CANONICAL=Q5EA45-1" }, "locus": { "chromosome": "29", "start_pos": 29624223, "end_pos": 29617522, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066206.4", "url": "https://www.ensembl.org/id/ENSBTAT00000066206.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055565.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055565.3" } ] } }, { "isoform_ac": "A0A452DJZ0-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA45/entry#A0A452DJZ0-1", "sequence": { "sequence": "MLRRALRLRLGPCLSGRGLGTYRRGSTLDWDGKVSEIKKKIQSIFPGGAWNPLYDTSHLPPERSDVYARASTVLSVGGIRQQFSLPQNVQLSLFSAEFLRNINEYLAVVDDPPLDLQFNPSGYLLLASEEGAAIMERNVKMQRQEGAKVCLMSPEQLQKKFPWINTEGVALASYGLENEGWFDPWCLLQGLRRKLQSMGVLFCQGEVTRFISSSSHMETASGEQLTLKRIHEVHVKMDHSQEFQPVECAIVVNAAGAWSGQIAELAGVGNGPPGTMQGTKLPVEPRKRYVYLWHCPQGPGLEAPLVADPSGAYFRREGLGNNYVGSCSPTEEEEPDPGNLEVDYDFFQEKVWPRLAQRVPAFETLKVRSAWAGYYDYNTFDQNGVVGPHPLVINMYFATGFSGHGLQQAPAVGRAVAEMVLEGHFQTINLSPFLFSRFYFGEKAQEHCIL", "length": 450, "header": "tr|A0A452DJZ0-1|FXRD1_BOVIN Computationally mapped isoform of FAD-dependent oxidoreductase domain-containing protein 1 OS=Bos taurus OX=9913 GN=FOXRED1 PE=2 SV=2 CANONICAL=Q5EA45-1" }, "locus": { "chromosome": "29", "start_pos": 29624657, "end_pos": 29617522, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030276.6", "url": "https://www.ensembl.org/id/ENSBTAT00000030276.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030261.5", "url": "https://www.ensembl.org/id/ENSBTAP00000030261.5" } ] } }, { "isoform_ac": "A0AAA9RU49-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA45/entry#A0AAA9RU49-1", "sequence": { "sequence": "MLRRALRLRLGPCLSGRGLGTYRRGSTLDWDGKVSEIKKKIQSIFPGGAWNPLYDTSHLPPERSDVVIGGGVLGLSVAYWLKRLEKQQGAIRVLVVERDHTYARASTVLSVGGIRQQFSLPQNVQLSLFSAEFLRNINEYLAVVDDPPLDLQFNPSGYLLLASEEGAAIMERNVKMQRQEGAKVCLMSPEQLQKKFPWINTEGVALASYGLENEGWFDPWCLLQGLRRKLQSMGVLFCQGEVTRFISSSSHMETASGEQLTLKRIHEVHVKMDHSQEFQPVECAIVVNAAGAWSGQIAELAGVGNGPPGTMQGTKLPVEPRKRYVYLWHCPQGPGLEAPLVADPSGAYFRREGLGNNYVGSCSPTEPLPTKGTN", "length": 374, "header": "tr|A0AAA9RU49-1|FXRD1_BOVIN Computationally mapped isoform of FAD-dependent oxidoreductase domain-containing protein 1 OS=Bos taurus OX=9913 GN=FOXRED1 PE=2 SV=1 CANONICAL=Q5EA45-1" }, "locus": { "chromosome": "29", "start_pos": 29624025, "end_pos": 29617522, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102317.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102317.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075590.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075590.1" } ] } }, { "isoform_ac": "A0AAA9SAF8-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA45/entry#A0AAA9SAF8-1", "sequence": { "sequence": "MLRRALRLRLGPCLSGRGLGTYRRGSTLDWDGKVSEIKKKIQSIFPGGAWNPLYDTSHLPPERSDVVIVGGVLGLSVAYWLKRLEKQQGAIRVLVVERDHTYARASTVLSVGGIRQQFSLPQNVQLSLFSAEFLRNINEYLAVVDDPPLDLQFNPSGYLLLASEEGAAIMERNVKMQRQEGAKVCLMSPEQLQKKFPWINTEGVALASYGLENEGWFDPWCLLQGLRRKLQSMGVLFCQGEVTRFISSSSHMETASGEQLTLKRIHEVHVKMDHSQEFQPVECAIVVNAAGAWSGQIAELAGVGNGPPGTMQGTKLPVEPRKRRRNQTQGTWKWTTTSSRRRCGPVWPR", "length": 349, "header": "tr|A0AAA9SAF8-1|FXRD1_BOVIN Computationally mapped isoform of FAD-dependent oxidoreductase domain-containing protein 1 OS=Bos taurus OX=9913 GN=FOXRED1 PE=2 SV=1 CANONICAL=Q5EA45-1" }, "locus": { "chromosome": "29", "start_pos": 29624178, "end_pos": 29617522, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129587.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129587.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079160.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079160.1" } ] } }, { "isoform_ac": "A0AAA9TR65-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA45/entry#A0AAA9TR65-1", "sequence": { "sequence": "MERRYWDGKVSEIKKKIQSIFPGGAWNPLYDTSHLPPERSDVVIRLEKQQGAIRVLVVERDHTYARASTVLSVGGIRQQFSLPQNVQLSLFSAEFLRNINEYLAVVDDPPLDLQFNPSGYLLLASEEGAAIMERNVKMQRQEGAKVCLMSPEQLQKKFPWINTEGVALASYGLENEGWFDPWCLLQGLRRKLQSMGVLFCQGEVTRFISSSSHMETASGEQLTLKRIHEVHVKMDHSQEFQPVECAIVVNAAGAWSGQIAELAGVGNGPPGTMQGTKLPVEPRKRYVYLWHCPQGPGLEAPLVADPSGAYFRREGLGNNYVGSCSPTEEEEPDPGNLEVDYDFFQEKVWPRLAQRVPAFETLKVRSAWAGYYDYNTFDQNGVVGPHPLVINMYFATGFSGHGLQQAPAVGRAVAEMVLEGHFQTINLSPFLFSRFYFGEKAQEHCIL", "length": 447, "header": "tr|A0AAA9TR65-1|FXRD1_BOVIN Computationally mapped isoform of FAD-dependent oxidoreductase domain-containing protein 1 OS=Bos taurus OX=9913 GN=FOXRED1 PE=2 SV=2 CANONICAL=Q5EA45-1" }, "locus": { "chromosome": "29", "start_pos": 29624657, "end_pos": 29619654, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103049.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103049.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099795.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099795.1" } ] } }, { "isoform_ac": "Q5EA45-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA45/entry#Q5EA45-1", "sequence": { "sequence": "MLRRALRLRLGPCLSGRGLGTYRRGSTLDWDGKVSEIKKKIQSIFPGGAWNPLYDTSHLPPERSDVVIVGGGVLGLSVAYWLKRLEKQQGAIRVLVVERDHTYARASTVLSVGGIRQQFSLPQNVQLSLFSAEFLRNINEYLAVVDDPPLDLQFNPSGYLLLASEEGAAIMERNVKMQRQEGAKVCLMSPEQLQKKFPWINTEGVALASYGLENEGWFDPWCLLQGLRRKLQSMGVLFCQGEVTRFISSSSHMETASGEQLTLKRIHEVHVKMDHSQEFQPVECAIVVNAAGAWSGQIAELAGVGNGPPGTMQGTKLPVEPRKRYVYLWHCPQGPGLEAPLVADPSGAYFRREGLGNNYVGSCSPTEEEEPDPGNLEVDYDFFQEKVWPRLAQRVPAFETLKVRSAWAGYYDYNTFDQNGVVGPHPLVVNMYFATGFSGHGLQQAPAVGRAVAEMVLEGHFQTINLSPFLFSRFYFGEKAQEHCIL", "length": 486, "header": "sp|Q5EA45-1|FXRD1_BOVIN Isoform 1 of FAD-dependent oxidoreductase domain-containing protein 1 OS=Bos taurus OX=9913 GN=FOXRED1 PE=2 SV=1 CANONICAL=Q5EA45-1" }, "locus": {} }, { "isoform_ac": "Q5EA45-2", "url": "https://www.uniprot.org/uniprotkb/Q5EA45/entry#Q5EA45-2", "sequence": { "sequence": "MLRRALRLRLGPCLSGRGLGTYRRGSTLDWDGKVSEIKKKIQSIFPGGAWNPLYDTSHLPPERSDVVIVGGGVLGLSVAYWLKRLEKQQGAIRVLVVERDHTYARASTVLSVGGIRQQFSLPQNVQLSLFSAEFLRNINEYLAVVDDPPLDLQFNPSGYLLLASEEGAAIMERNVKMQRQEGAKVCLMSPEQLQKKFPWINTEGVALASYGLENEGWFDPWCLLQGLRRKLQSMGVLFCQGEVTRFISSSSHMETASGEQLTLKRIHEVHVKMDHSQEFQPVECAIVVNAAGAWSGQIAELAGVGNGPPGTMQGTKLPVEPRKRYVYLWHCPQGPGLEAPLVADPSGAYFRREGLGNNYVGSCSPTEPLPTKGTN", "length": 375, "header": "sp|Q5EA45-2|FXRD1_BOVIN Isoform 2 of FAD-dependent oxidoreductase domain-containing protein 1 OS=Bos taurus OX=9913 GN=FOXRED1 PE=2 SV=1 CANONICAL=Q5EA45-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA45", "url": "https://www.uniprot.org/uniprotkb/Q5EA45" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:510097", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510097", "resource": "KEGG Pathway" }, { "id": "R-BTA-6799198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "resource": "Reactome", "description": "Complex I biogenesis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5EA45", "url": "https://www.uniprot.org/uniprotkb/Q5EA45" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q5EA45", "url": "https://www.uniprot.org/uniprotkb/Q5EA45" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "Q5EA45", "url": "https://www.uniprot.org/uniprotkb/Q5EA45" } ], "pmid": "" }, { "name": "respiratory electron transport chain", "id": "GO:0022904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022904", "evidence": [ { "database": "UniProtKB", "id": "Q5EA45", "url": "https://www.uniprot.org/uniprotkb/Q5EA45" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "Q5EA45", "url": "https://www.uniprot.org/uniprotkb/Q5EA45" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 465, "end_pos": 467, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA45-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 486, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA45-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA45" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 465, "end_pos": 467 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9I6-1", "uniprot_ac": "Q5E9I6", "uniprot_id": "ARF3_BOVIN", "mass": { "chemical_mass": 20601.0, "monoisotopic_mass": 20601.0 }, "refseq": { "ac": "NP_001015571", "name": "ADP-ribosylation factor 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015571" }, "gene_names": [ { "name": "ARF3", "type": "recommended", "evidence": [ { "id": "Q5E9I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9I6" } ] }, { "name": "ARF3", "type": "synonym", "evidence": [ { "id": "NP_001015571", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015571" } ] } ], "protein_names": [ { "name": "ADP-ribosylation factor 3", "type": "recommended", "evidence": [ { "id": "Q5E9I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9I6/entry#names_and_taxonomy" } ] }, { "name": "ADP ribosylation factor 3", "type": "synonym", "evidence": [ { "id": "NP_001015571", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015571" } ] }, { "name": "ADP-ribosylation factor 3", "type": "synonym", "evidence": [ { "id": "NP_001015571", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015571" } ] } ], "function": [ { "annotation": "GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I6", "url": "https://www.uniprot.org/uniprotkb/Q5E9I6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9I6", "url": "https://www.uniprot.org/uniprotkb/Q5E9I6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARF3", "url": "https://www.uniprot.org/uniprotkb/Q5E9I6", "locus": { "chromosome": "5", "start_pos": 30881412, "end_pos": 30855778, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000051755", "url": "https://www.ensembl.org/id/ENSBTAG00000051755" } ] } } ], "crossref": [ { "id": "Q5E9I6", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9I6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051755", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051755", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04150", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04150", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510994", "url": "https://www.ncbi.nlm.nih.gov/gene/510994", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006689", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006689", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510994", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510994", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IRQRHWF", "url": "https://omabrowser.org/oma/group/IRQRHWF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9I6", "url": "https://www.orthodb.org/?gene=Q5E9I6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11711", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11711", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00025", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00025", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1660514", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660514", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6807878", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811434", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811434", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015571", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RUA9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUA9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUS5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUS5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUS5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NVP2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NVP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NVP2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NVP2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P7X3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P7X3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P7X3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P7X3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9I6", "url": "https://www.uniprot.org/uniprotkb/Q5E9I6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9I6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQLKNKK", "length": 181, "header": "sp|Q5E9I6-1|ARF3_BOVIN Isoform 1 of ADP-ribosylation factor 3 OS=Bos taurus OX=9913 GN=ARF3 PE=2 SV=3 CANONICAL=Q5E9I6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RUA9-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I6/entry#A0AAA9RUA9-1", "sequence": { "sequence": "MELCGPSLPRARRRGAGPATRLPPHLKDAELVWGWGAHTVLSSASHKGATWAAVRSPSPAGGSSPPYQGPGPNQTATAPTAPYCPQKASAVIMGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQLKNKKNSLVVHWLGLSTVTARAPGSIPGRGTKIPWF", "length": 304, "header": "tr|A0AAA9RUA9-1|ARF3_BOVIN Computationally mapped isoform of ADP-ribosylation factor 3 OS=Bos taurus OX=9913 GN=ARF3 PE=2 SV=2 CANONICAL=Q5E9I6-1" }, "locus": { "chromosome": "5", "start_pos": 30881133, "end_pos": 30856053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126086.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126086.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076744.2", "url": "https://www.ensembl.org/id/ENSBTAP00000076744.2" } ] } }, { "isoform_ac": "A0AAA9SUS5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I6/entry#A0AAA9SUS5-1", "sequence": { "sequence": "MELCGPSLPRARRRGAGPATRLPPHLKDAELVWGWGAHTVLSSASHKGATWAAVRSPSPAGGSSPPYQGPGPNQTATAPTAPYCPQKASAVIMGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQLKNKNPGHAERWKFLFPDPETILPSLPTPSQQPFPALSTHFP", "length": 310, "header": "tr|A0AAA9SUS5-1|ARF3_BOVIN Computationally mapped isoform of ADP-ribosylation factor 3 OS=Bos taurus OX=9913 GN=ARF3 PE=2 SV=2 CANONICAL=Q5E9I6-1" }, "locus": { "chromosome": "5", "start_pos": 30872169, "end_pos": 30856053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110912.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110912.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090214.2", "url": "https://www.ensembl.org/id/ENSBTAP00000090214.2" } ] } }, { "isoform_ac": "A0ABI0NVP2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I6/entry#A0ABI0NVP2-1", "sequence": { "sequence": "MELCGPSLPRARRRGAGPATRLPPHLKDAELVWGWGAHTVLSSASHKGATWAAVRSPSPAGGSSPPYQGPGPNQTATAPTAPYCPQKASAVIMGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQLKNKK", "length": 273, "header": "tr|A0ABI0NVP2-1|A0ABI0NVP2_BOVIN Computationally mapped isoform of ADP ribosylation factor 3 OS=Bos taurus OX=9913 GN=ARF3 PE=3 SV=1 CANONICAL=Q5E9I6-1" }, "locus": { "chromosome": "5", "start_pos": 30870837, "end_pos": 30856053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000142890.1", "url": "https://www.ensembl.org/id/ENSBTAT00000142890.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104412.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104412.1" } ] } }, { "isoform_ac": "A0ABI0P7X3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I6/entry#A0ABI0P7X3-1", "sequence": { "sequence": "MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQLKNKK", "length": 144, "header": "tr|A0ABI0P7X3-1|A0ABI0P7X3_BOVIN Computationally mapped isoform of ADP ribosylation factor 3 OS=Bos taurus OX=9913 GN=ARF3 PE=3 SV=1 CANONICAL=Q5E9I6-1" }, "locus": { "chromosome": "5", "start_pos": 30870837, "end_pos": 30868695, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147104.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147104.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107390.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107390.1" } ] } }, { "isoform_ac": "Q5E9I6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I6/entry#Q5E9I6-1", "sequence": { "sequence": "MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQLKNKK", "length": 181, "header": "sp|Q5E9I6-1|ARF3_BOVIN Isoform 1 of ADP-ribosylation factor 3 OS=Bos taurus OX=9913 GN=ARF3 PE=2 SV=3 CANONICAL=Q5E9I6-1" }, "locus": { "chromosome": "5", "start_pos": 30870837, "end_pos": 30868695, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000143085.1", "url": "https://www.ensembl.org/id/ENSBTAT00000143085.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107087.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107087.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I6", "url": "https://www.uniprot.org/uniprotkb/Q5E9I6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:510994", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510994", "resource": "KEGG Pathway" }, { "id": "R-BTA-1660514", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660514", "resource": "Reactome", "description": "Synthesis of PIPs at the Golgi membrane" }, { "id": "R-BTA-6807878", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "resource": "Reactome", "description": "COPI-mediated anterograde transport" }, { "id": "R-BTA-6811434", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811434", "resource": "Reactome", "description": "COPI-dependent Golgi-to-ER retrograde traffic" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1P8BDK6-1", "protein_name": "ADP-ribosylation factor", "gene_name": "ARFA1B", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGLNFTKLFSRLFAKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRDRVVEARDELHRMLNEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRQRHWYIQSTCATSGEGLYEGLDWLSNNIATKA", "length": 181 }, "evidence": [ { "id": "Q5E9I6", "url": "https://omabrowser.org/oma/group/Q5E9I6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "A0A4X1WCQ9-1", "protein_name": "ARF GTPase 3", "gene_name": "ARF3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQLKNKK", "length": 144 }, "evidence": [ { "id": "Q5E9I6", "url": "https://omabrowser.org/oma/group/Q5E9I6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3I6J4-1", "protein_name": "ADP-ribosylation factor", "gene_name": "Arf3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQLKNKK", "length": 181 }, "evidence": [ { "id": "Q5E9I6", "url": "https://omabrowser.org/oma/group/Q5E9I6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P11076-1", "protein_name": "ADP-ribosylation factor 1", "gene_name": "ARF1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MGLFASKLFSNLFGNKEMRILMVGLDGAGKTTVLYKLKLGEVITTIPTIGFNVETVQYKNISFTVWDVGGQDRIRSLWRHYYRNTEGVIFVVDSNDRSRIGEAREVMQRMLNEDELRNAAWLVFANKQDLPEAMSAAEITEKLGLHSIRNRPWFIQATCATSGEGLYEGLEWLSNSLKNST", "length": 181 }, "evidence": [ { "id": "Q5E9I6", "url": "https://omabrowser.org/oma/group/Q5E9I6/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P61205-1", "protein_name": "ADP-ribosylation factor 3", "gene_name": "Arf3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQLKNKK", "length": 181 }, "evidence": [ { "id": "Q5E9I6", "url": "https://omabrowser.org/oma/group/Q5E9I6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P61206-1", "protein_name": "ADP-ribosylation factor 3", "gene_name": "Arf3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQLKNKK", "length": 181 }, "evidence": [ { "id": "Q5E9I6", "url": "https://omabrowser.org/oma/group/Q5E9I6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I6", "url": "https://www.uniprot.org/uniprotkb/Q5E9I6" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I6", "url": 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"MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETISPEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLIAGNPQTVHSAGPGSGSSVSMNQQNPQTPQAQTLSGMHVNGAPPLMQASLQAGVAAPGQIPATVTGPGPGSLAPAGGMQAQVGMPGSGPVSMERGQVPMQDPRAAMQRGPLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVPGHDSRGPPPHEMRGGPLTEPRPLMAEPRGPMIDQRGPPLDGRGGRDPRGIDARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARSMDTRGPVPGPRGPMPSGIQGPSPINMGAVGPQGSRQVPVMQGAGMQGASIQGGGQPGGFSPGQNQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP", "length": 572, "header": "sp|Q8HXM1-1|CSTF2_BOVIN Isoform 1 of Cleavage stimulation factor subunit 2 OS=Bos taurus OX=9913 GN=CSTF2 PE=2 SV=1 CANONICAL=Q8HXM1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RX58-1", "url": "https://www.uniprot.org/uniprotkb/Q8HXM1/entry#A0AAA9RX58-1", "sequence": { "sequence": "MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETISPEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLIAGNPQTVHSAGPGSGSSVSMNQQNPQTPQAQTLSGMHVNGAPPLMQASLQAGVAAPGQIPATVTGPGPGSLAPAGGMQAQVGMPGSGPVSMERGQVPMQDPRAAMQRGPLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVPGHDSRGPPPHEMRGGPLTEPRPLMAEPRGPMIDQRGPPLDGRGGRDPRGIDARAMEARGLDARGLEARAMEARAMEARAMEVRGMEARSMDTRGPVPGPRGPMPSGIQGPSPINMGAVGPQGSRQVPVMQGAGMQGASIQGGGQPGGFSPGQNQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP", "length": 562, "header": "tr|A0AAA9RX58-1|CSTF2_BOVIN Computationally mapped isoform of Cleavage stimulation factor subunit 2 OS=Bos taurus OX=9913 GN=CSTF2 PE=2 SV=1 CANONICAL=Q8HXM1-1" }, "locus": { "chromosome": "X", "start_pos": 51381345, "end_pos": 51351931, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131175.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131175.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077076.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077076.1" } ] } }, { "isoform_ac": "A0AAA9TXF0-1", "url": "https://www.uniprot.org/uniprotkb/Q8HXM1/entry#A0AAA9TXF0-1", "sequence": { "sequence": "MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETISPEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLIAGNPQTVHSAGPGSGSSVSMNQQNPQTPQAQTLSGMHVNGAPPLMQASLQAGVAAPGQIPATVTGPGPGSLAPAANITVLRKRKLLLCGKDQTSTYGGMQAQVGMPGSGPVSMERGQGTVQHSPVGPTGPASIERVQVPMQDPRAAMQRGPLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVPGHDSRGPPPHEMRGGPLTEPRPLMAEPRGPMIDQRGPPLDGRGGRDPRGIDARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARSMDTRGPVPGPRGPMPSGIQGPSPINMGAVGPQGSRQVPVMQGAGMQGASIQGGGQPGGFSPGQNQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP", "length": 614, "header": "tr|A0AAA9TXF0-1|CSTF2_BOVIN Computationally mapped isoform of Cleavage stimulation factor subunit 2 OS=Bos taurus OX=9913 GN=CSTF2 PE=2 SV=1 CANONICAL=Q8HXM1-1" }, "locus": { "chromosome": "X", "start_pos": 51381345, "end_pos": 51351931, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123805.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123805.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103329.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103329.1" } ] } }, { "isoform_ac": "A0AAF6YL13-1", "url": "https://www.uniprot.org/uniprotkb/Q8HXM1/entry#A0AAF6YL13-1", "sequence": { "sequence": "MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETISPEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLIAGNPQTVHSAGPGSGSSVSMNQQNPQTPQAQTLSGMHVNGAPPLMQASLQAGVAAPGQIPATVTGPGPGSLAPAANITVLRKRKLLLCGKDQTSTYGGMQAQVGMPGSGPVSMERGQVPMQDPRAAMQRGPLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVPGHDSRGPPPHEMRGGPLTEPRPLMAEPRGPMIDQRGPPLDGRGGRDPRGIDARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARSMDTRGPVPGPRGPMPSGIQGPSPINMGAVGPQGSRQVPVMQGAGMQGASIQGGGQPGGFSPGQNQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP", "length": 594, "header": "tr|A0AAF6YL13-1|CSTF2_BOVIN Computationally mapped isoform of Cleavage stimulation factor subunit 2 OS=Bos taurus OX=9913 GN=CSTF2 PE=2 SV=1 CANONICAL=Q8HXM1-1" }, "locus": { "chromosome": "X", "start_pos": 51381345, "end_pos": 51351931, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004619.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004619.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004619.7", "url": "https://www.ensembl.org/id/ENSBTAP00000004619.7" } ] } }, { "isoform_ac": "F1MVI1-1", "url": "https://www.uniprot.org/uniprotkb/Q8HXM1/entry#F1MVI1-1", "sequence": { "sequence": "MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETISPEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLIAGNPQTVHSAGPGSGSSVSMNQQNPQTPQAQTLSGMHVNGAPPLMQASLQAGVAAPGQIPATVTGPGPGSLAPAGGMQAQVGMPGSGPVSMERGQGTVQHSPVGPTGPASIERVQVPMQDPRAAMQRGPLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVPGHDSRGPPPHEMRGGPLTEPRPLMAEPRGPMIDQRGPPLDGRGGRDPRGIDARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARSMDTRGPVPGPRGPMPSGIQGPSPINMGAVGPQGSRQVPVMQGAGMQGASIQGGGQPGGFSPGQNQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP", "length": 592, "header": "tr|F1MVI1-1|CSTF2_BOVIN Computationally mapped isoform of Cleavage stimulation factor subunit 2 OS=Bos taurus OX=9913 GN=CSTF2 PE=2 SV=1 CANONICAL=Q8HXM1-1" }, "locus": { "chromosome": "X", "start_pos": 51381345, "end_pos": 51351931, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045511.3", "url": "https://www.ensembl.org/id/ENSBTAT00000045511.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042892.2", "url": "https://www.ensembl.org/id/ENSBTAP00000042892.2" } ] } }, { "isoform_ac": "Q8HXM1-1", "url": "https://www.uniprot.org/uniprotkb/Q8HXM1/entry#Q8HXM1-1", "sequence": { "sequence": "MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETISPEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLIAGNPQTVHSAGPGSGSSVSMNQQNPQTPQAQTLSGMHVNGAPPLMQASLQAGVAAPGQIPATVTGPGPGSLAPAGGMQAQVGMPGSGPVSMERGQVPMQDPRAAMQRGPLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVPGHDSRGPPPHEMRGGPLTEPRPLMAEPRGPMIDQRGPPLDGRGGRDPRGIDARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARSMDTRGPVPGPRGPMPSGIQGPSPINMGAVGPQGSRQVPVMQGAGMQGASIQGGGQPGGFSPGQNQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP", "length": 572, "header": "sp|Q8HXM1-1|CSTF2_BOVIN Isoform 1 of Cleavage stimulation factor subunit 2 OS=Bos taurus OX=9913 GN=CSTF2 PE=2 SV=1 CANONICAL=Q8HXM1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 14, "end_pos": 14, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8HXM1", "url": "https://www.uniprot.org/uniprotkb/Q8HXM1" } ], "site_lbl": "Ser14" }, { "start_pos": 519, "end_pos": 519, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8HXM1", "url": "https://www.uniprot.org/uniprotkb/Q8HXM1" } ], "site_lbl": "Ser519" } ], "glycation": [], "keywords": [], "publication": [ { "title": "The gene CSTF2T, encoding the human variant CstF-64 polyadenylation protein CstF-64, lacks introns and may be associated with male sterility.", "journal": "Genomics", "date": "2002", "authors": "Dass B, McDaniel L, Schultz RA, Attaya E, MacDonald CC", "evidence": [ { "database": "UniProtKB", "id": "Q8HXM1", "url": "https://www.uniprot.org/uniprotkb/Q8HXM1" } ], "reference": [ { "type": "PubMed", "id": "12408968", "url": "https://glygen.org/publication/PubMed/12408968" } ] } ], "pathway": [ { "id": "bta:282588", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282588", "resource": "KEGG Pathway" }, { "id": "R-BTA-73856", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73856", "resource": "Reactome", "description": "RNA Polymerase II Transcription Termination" }, { "id": "R-BTA-77595", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77595", "resource": "Reactome", "description": "Processing of Intronless Pre-mRNAs" }, { "id": "R-BTA-9770562", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770562", "resource": "Reactome", "description": "mRNA Polyadenylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4I9I2-1", "protein_name": "Cleavage stimulation factor subunit 2 isoform X1", "gene_name": "cstf2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MANLAVAAAAAAAARDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGLVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPIIESPYGDGCMPEEAPESISRAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKMLHRPAVVPPINPSPQPGAVPAPNQPLPQPNVPVSQPQPMPGLHVNGAPQMMQPPQMGGGVPGPMPGQGPMGPAGGMQPQIGIPPGGPVPMDRGPGNLQDSPVGAAGQAAIERSQVPIVDPRAPMRGAPQGPPGIPPRGLLGDGPNDPRGGSLVSVTGEVVEPGRGYIGGPPQHQGPPMHMAPPDMRGPHDMRGGPMMGEPRGPMMEQRGPPIEARGRDPRAVDARGPIAGPRGPVAGGMQGPPPHGMGPGAPPPARPGPGSDVSSQDHEKAALIMQVLQLTPEQIAMLPAEQRQSILILKEQIQKTAGAP", "length": 508 }, "evidence": [ { "id": "Q8HXM1", "url": "https://omabrowser.org/oma/group/Q8HXM1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8J8XR33-1", "protein_name": "Cleavage stimulation factor subunit 2", "gene_name": "Cstf2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGLPVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGESISPEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLISGNPQPVHVAGPGSGPNVSMNQQNPQAPQAQSLSGMHVNGAPPMMQASMPGGVPAPVQMAAAVAGPGPGSLAPAGVMQAQVGMQGAGPVPMERGQGTLQHSPVGPAGPASIERVQGQRTWMIWASVRGSTPSLLVSGGLDGIAVLPMQDPRAAMQRGALPANVPTPRGLLGDAPNDPRGGTLMTVTGEVEPRAYLGPPPPPHQGPPMHHVPGHEGRGPPPHDMRGGPLAEPRPLMAEPRGPMLDQRGPPLDARGGRDPRGLDARGMEARAMEARGLEARAMEARAMEARAMEARAMEARAMEARAMEARGMDTRGPVPGPRGPIPSGIQGPNPMNMGAVVPQGSRQVPVMQGAGMQGASMQGGSQPGGFSPGQSQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP", "length": 624 }, "evidence": [ { "id": "Q8HXM1", "url": "https://omabrowser.org/oma/group/Q8HXM1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0YX48-1", "protein_name": "Cleavage stimulation factor subunit 2", "gene_name": "CSTF2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGLSVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPIIESPYGDPVNPEDAPESISRAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTSVPPLIPGNQQAVPGPGPGPGPGPGPNAQLNPQNTPSSQPQPIGGMHVNGAPPLMQPPMQGGVPAPGQMAAAVQGPGPGPMAPGGGLQPQVGMPGGGPVPLERGQGTLQLSPVGPARPASIERVQVPMPDPRAPMQRGPLPASGPPPRGLLGDAPNDPRGGTLLSVTGDVEPRGYLGPPHQGAPMHHMPGHDSRGPPHEMRGGPMGEPRPLMGEPRGPLMDARVGRDPRGLEPRGLEPRGLEPRVMEARGLEPRGMEPRVLEPRVLEARAMEARVMESRGLEPRGPGPNPRGPMAGGIQGPGPLNMGASGPQGPRQVPNMAGAGMQGGGIPGAGVQGAGQPGGFSPGQSQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP", "length": 593 }, "evidence": [ { "id": "Q8HXM1", "url": "https://omabrowser.org/oma/group/Q8HXM1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S1L9-1", "protein_name": "Cleavage stimulation factor subunit 2", "gene_name": "CSTF2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETISPEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLIAGNPQTVHSTGPGSGSNVSMNQQNPQAPQAQSLSGMHVNGAPPLMQASLQAGVAAPGQIPATVTGPGPGSLAPGGGMQAQVGMPGSGPVSMERGQVPMQDPRAAMQRGPLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRSYLGPPHQGPPMHHVPGHDSRGPPPHEMRGGPLAEPRPLMAEPRGPMLDQRGPPLDGRGGRDPRGIDARGMEARAMEARGLDARGLEARAMEARAMEARAMEARAMEVRGMEARSMDTRGPVPGPRGPMPSGIQGPSPINMGAVGPQGSRQVPVMQGAGMQGASIQAGGQPGGFSPGQNQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP", "length": 572 }, "evidence": [ { "id": "Q8HXM1", "url": "https://omabrowser.org/oma/group/Q8HXM1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P33240-1", "protein_name": "Cleavage stimulation factor subunit 2", "gene_name": "CSTF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETISPEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLIAGNPQPVHGAGPGSGSNVSMNQQNPQAPQAQSLGGMHVNGAPPLMQASMQGGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSMERGQVPMQDPRAAMQRGSLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVPGHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLDGRGGRDPRGIDARGMEARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARGMDTRGPVPGPRGPIPSGMQGPSPINMGAVVPQGSRQVPVMQGTGMQGASIQGGSQPGGFSPGQNQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP", "length": 577 }, "evidence": [ { "id": "Q8HXM1", "url": "https://omabrowser.org/oma/group/Q8HXM1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BIQ5-1", "protein_name": "Cleavage stimulation factor subunit 2", "gene_name": "Cstf2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGLPVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGESISPEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLISGNPQPVHVAGPGSGPNVSMNQQNPQAPQAQSLGGMHVNGAPPMMQASMPGGVPAPVQMAAAVGGPGPGSLAPAGVMQAQVGMQGAGPVPMERGQVPMQDPRAAMQRGALPTNVPTPRGLLGDAPNDPRGGTLMTVTGDVEPRAYLGPPPPPHQGPPMHHVPGHEGRGPPPHDMRGGPLAEPRPLMAEPRGPMLDQRGPPLDARGGRDPRGLDARGMEARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEARAMEARGMDTRGPVPGPRGPMPSGIQGPNPMNMGAVVPQGSRQVPVMQGAGMQGASMQGGSQPGGFSPGQSQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP", "length": 580 }, "evidence": [ { "id": "Q8HXM1", "url": "https://omabrowser.org/oma/group/Q8HXM1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "Q8HXM1", "url": "https://www.uniprot.org/uniprotkb/Q8HXM1" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q8HXM1", "url": "https://www.uniprot.org/uniprotkb/Q8HXM1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q8HXM1", "url": "https://www.uniprot.org/uniprotkb/Q8HXM1" } ], "pmid": "" }, { "name": "mRNA cleavage and polyadenylation specificity factor complex", "id": "GO:0005847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005847", "evidence": [ { "database": "UniProtKB", "id": "Q8HXM1", "url": "https://www.uniprot.org/uniprotkb/Q8HXM1" } ], "pmid": "" }, { "name": "cleavage body", "id": "GO:0071920", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071920", "evidence": [ { "database": "UniProtKB", "id": "Q8HXM1", "url": "https://www.uniprot.org/uniprotkb/Q8HXM1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mRNA 3'-end processing", "id": "GO:0031124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031124", "evidence": [ { "database": "UniProtKB", "id": "Q8HXM1", "url": "https://www.uniprot.org/uniprotkb/Q8HXM1" } ], "pmid": "" }, { "name": "regulation of mRNA 3'-end processing", "id": "GO:0031440", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031440", "evidence": [ { "database": "UniProtKB", "id": "Q8HXM1", "url": "https://www.uniprot.org/uniprotkb/Q8HXM1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q8HXM1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 572, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q8HXM1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q8HXM1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q8HXM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HXM1" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000255", "start_pos": 16, "end_pos": 94, "start_aa": "Arg", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 14, 519 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "A6QLU5-1", "uniprot_ac": "A6QLU5", "uniprot_id": "ZN184_BOVIN", "mass": { "chemical_mass": 86023.0, "monoisotopic_mass": 86023.0 }, "refseq": { "ac": "NP_001093842", "name": "zinc finger protein 184", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093842" }, "gene_names": [ { "name": "ZNF184", "type": "recommended", "evidence": [ { "id": "A6QLU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLU5" } ] }, { "name": "ZNF184", "type": "synonym", "evidence": [ { "id": "NP_001093842", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093842" } ] } ], "protein_names": [ { "name": "Zinc finger protein 184", "type": "recommended", "evidence": [ { "id": "A6QLU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLU5/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 184", "type": "synonym", "evidence": [ { "id": "NP_001093842", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093842" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A6QLU5", "url": "https://www.uniprot.org/uniprotkb/A6QLU5#function" }, { "database": "UniProtKB", "id": "A0ABI0NQB4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQB4#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0ABI0P6Q2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6Q2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QLU5", "url": "https://www.uniprot.org/uniprotkb/A6QLU5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF184", "url": "https://www.uniprot.org/uniprotkb/A6QLU5", "locus": {} } ], "crossref": [ { "id": "A6QLU5", "url": "https://alphafold.ebi.ac.uk/entry/A6QLU5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515674", "url": "https://www.ncbi.nlm.nih.gov/gene/515674", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050826", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050826", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515674", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515674", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A6QLU5", "url": "https://www.orthodb.org/?gene=A6QLU5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF85", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF85", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24377", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24377", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384:SF246", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384:SF246", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33426", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33426", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33426:SF43", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33426:SF43", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13465", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13465", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001093842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093842", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S329", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S329", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S329-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S329-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQB4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQB4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQB4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6Q2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6Q2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6Q2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6Q2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QLU5", "url": "https://www.uniprot.org/uniprotkb/A6QLU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QLU5-1", "url": "https://www.uniprot.org/uniprotkb/A6QLU5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDLSAPESALFQGGHTLLPSASFQESVTFKDVIVDFTQEEWKQLDPVQRGLFRDVTLENYTHLVSIGLQVSKPDVISQLEQGTEPWIVEPSIPVGTPGDWVTRPENSITASELDISGEEPSPGAVAEKHKRDDPWSTNFLETCESKGSPERQQANKQTLPREIKITEKTIPTLEQAHVNNDFEKSISVSLDLLTHKQISPKQTSTKTNVKQNLNPVKKEKSCKCNECGKAFTYCSALIRHQRTHTGEKPYKCNECEKAFSRSENLINHQRIHTGDKPYKCDQCGKGFIEGPSLTQHQRIHTGEKPYKCDECGKAFSQRTHLVQHQRIHTGEKPYTCNECGKAFSQRGHFMEHQKIHTGEKPFKCDECDKTFTRSTHLTQHQKIHTGEKTYKCNECGKAFNGPSTFIRHHMIHTGEKPYECNECGKAFSQHSNLTQHQKTHTGEKPYDCAECGKSFSYWSSLAQHLKIHTGEKPYKCNECGKAFSYCSSLTQHRRIHTREKPFECSECGKAFSYLSNLNQHQKTHTQEKAYECKECGKAFIRSSSLAKHERIHTGEKPYQCHECGKTFSYGSSLIQHRKIHTGERPYKCNECGRAFNQNIHLTQHKRIHTGAKPYECAECGKAFRHCSSLAQHQKTHTEEKPYHCNKCEKAFSQSSHLAQHQRIHTGEKPYKCNECDKTFSRSTHLTEHQNTHTGEKPYNCNECRKTFSQSTYLIQHQRIHSAEKPFGCNDCGKAFRYRSALNKHQRLHPGI", "length": 752, "header": "sp|A6QLU5-1|ZN184_BOVIN Isoform 1 of Zinc finger protein 184 OS=Bos taurus OX=9913 GN=ZNF184 PE=2 SV=1 CANONICAL=A6QLU5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S329-1", "url": "https://www.uniprot.org/uniprotkb/A6QLU5/entry#A0AAA9S329-1", "sequence": { "sequence": "MDFLMLSKVCAPGKCFITFVAFKRFFSCMDFLMFHEVASLAKGFSTLITSIWFLTSVYSLMLNKVGSLTKSFPTFITLIGFFSSVNSLMLSKRWTLNEAFPALITFIWFISSMNSLMVYKVFTPAEGFFTFITFVGFFSSMRSLMANKS", "length": 149, "header": "tr|A0AAA9S329-1|ZN184_BOVIN Computationally mapped isoform of Zinc finger protein 184 OS=Bos taurus OX=9913 GN=ZNF184 PE=2 SV=1 CANONICAL=A6QLU5-1" }, "locus": { "chromosome": "23", "start_pos": 31184507, "end_pos": 31165682, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130726.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130726.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080327.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080327.1" } ] } }, { "isoform_ac": "A0ABI0NQB4-1", "url": "https://www.uniprot.org/uniprotkb/A6QLU5/entry#A0ABI0NQB4-1", "sequence": { "sequence": "ELDTAERLHFHFSLSCIGEGNGNPLQCSCLENPRDGSLVAAIYGVTQSRTRLKRLSSSSNLSAPESALFQGGHTLLPSASFQESVTFKDVIVDFTQEEWKQLDPVQRGLFRDVTLENYTHLVSIGLQVSKPDVISQLEQGTEPWIVEPSIPVGTPGDWVTRPENSITASELDISGEEPSPGAVAEKHKRDDPWSTNFLETCESKGSPERQQANKQTLPREIKITEKTIPTLEQAHVNNDFEKSISVSLDLLTHKQISPKQTSTKTNVKQNLNPVKKEKSCKCNECGKAFTYCSALIRHQRTHTGEKPYKCNECEKAFSRSENLINHQRIHTGDKPYKCDQCGKGFIEGPSLTQHQRIHTGEKPYKCDECGKAFSQRTHLVQHQRIHTGEKPYTCNECGKAFSQRGHFMEHQKIHTGEKPFKCDECDKTFTRSTHLTQHQKIHTGEKTYKCNECGKAFNGPSTFIRHHMIHTGEKPYECNECGKAFSQHSNLTQHQKTHTGEKPYDCAECGKSFSYWSSLAQHLKIHTGEKPYKCNECGKAFSYCSSLTQHRRIHTREKPFECSECGKAFSYLSNLNQHQKTHTQEKAYECKECGKAFIRSSSLAKHERIHTGEKPYQCHECGKTFSYGSSLIQHRKIHTGERPYKCNECGRAFNQNIHLTQHKRIHTGAKPYECAECGKAFRHCSSLAQHQKTHTEEKPYHCNKCEKAFSQSSHLAQHQRIHTGEKPYKCNECDKTFSRSTHLTEHQNTHTGEKPYNCNECRKTFSQSTYLIQHQRIHSAEKPFGCNDCGKAFRYRSALNKHQRLHPGI", "length": 809, "header": "tr|A0ABI0NQB4-1|A0ABI0NQB4_BOVIN Computationally mapped isoform of Zinc finger protein 184 OS=Bos taurus OX=9913 GN=ZNF184 PE=3 SV=1 CANONICAL=A6QLU5-1" }, "locus": { "chromosome": "23", "start_pos": 31184507, "end_pos": 31173573, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000142976.1", "url": "https://www.ensembl.org/id/ENSBTAT00000142976.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104359.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104359.1" } ] } }, { "isoform_ac": "A0ABI0P6Q2-1", "url": "https://www.uniprot.org/uniprotkb/A6QLU5/entry#A0ABI0P6Q2-1", "sequence": { "sequence": "MEGNGNPLQCSCLENPRDGSLVAAIYGVTQSRTRLKRLSSSSNLSAPESALFQGGHTLLPSASFQESVTFKDVIVDFTQEEWKQLDPVQRGLFRDVTLENYTHLVSIGLQVSKPDVISQLEQGTEPWIVEPSIPVGTPGDWVTRPENSITASELDISGEEPSPGAVAEKHKRDDPWSTNFLETCESKGSPERQQANKQTLPREIKITEKTIPTLEQAHVNNDFEKSISVSLDLLTHKQISPKQTSTKTNVKQNLNPVKKEKSCKCNECGKAFTYCSALIRHQRTHTGEKPYKCNECEKAFSRSENLINHQRIHTGDKPYKCDQCGKGFIEGPSLTQHQRIHTGEKPYKCDECGKAFSQRTHLVQHQRIHTGEKPYTCNECGKAFSQRGHFMEHQKIHTGEKPFKCDECDKTFTRSTHLTQHQKIHTGEKTYKCNECGKAFNGPSTFIRHHMIHTGEKPYECNECGKAFSQHSNLTQHQKTHTGEKPYDCAECGKSFSYWSSLAQHLKIHTGEKPYKCNECGKAFSYCSSLTQHRRIHTREKPFECSECGKAFSYLSNLNQHQKTHTQEKAYECKECGKAFIRSSSLAKHERIHTGEKPYQCHECGKTFSYGSSLIQHRKIHTGERPYKCNECGRAFNQNIHLTQHKRIHTGAKPYECAECGKAFRHCSSLAQHQKTHTEEKPYHCNKCEKAFSQSSHLAQHQRIHTGEKPYKCNECDKTFSRSTHLTEHQNTHTGEKPYNCNECRKTFSQSTYLIQHQRIHSAEKPFGCNDCGKAFRYRSALNKHQRLHPGI", "length": 792, "header": "tr|A0ABI0P6Q2-1|A0ABI0P6Q2_BOVIN Computationally mapped isoform of Zinc finger protein 184 OS=Bos taurus OX=9913 GN=ZNF184 PE=3 SV=1 CANONICAL=A6QLU5-1" }, "locus": { "chromosome": "23", "start_pos": 31184507, "end_pos": 31165682, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000141235.1", "url": "https://www.ensembl.org/id/ENSBTAT00000141235.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106710.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106710.1" } ] } }, { "isoform_ac": "A6QLU5-1", "url": "https://www.uniprot.org/uniprotkb/A6QLU5/entry#A6QLU5-1", "sequence": { "sequence": "MEDLSAPESALFQGGHTLLPSASFQESVTFKDVIVDFTQEEWKQLDPVQRGLFRDVTLENYTHLVSIGLQVSKPDVISQLEQGTEPWIVEPSIPVGTPGDWVTRPENSITASELDISGEEPSPGAVAEKHKRDDPWSTNFLETCESKGSPERQQANKQTLPREIKITEKTIPTLEQAHVNNDFEKSISVSLDLLTHKQISPKQTSTKTNVKQNLNPVKKEKSCKCNECGKAFTYCSALIRHQRTHTGEKPYKCNECEKAFSRSENLINHQRIHTGDKPYKCDQCGKGFIEGPSLTQHQRIHTGEKPYKCDECGKAFSQRTHLVQHQRIHTGEKPYTCNECGKAFSQRGHFMEHQKIHTGEKPFKCDECDKTFTRSTHLTQHQKIHTGEKTYKCNECGKAFNGPSTFIRHHMIHTGEKPYECNECGKAFSQHSNLTQHQKTHTGEKPYDCAECGKSFSYWSSLAQHLKIHTGEKPYKCNECGKAFSYCSSLTQHRRIHTREKPFECSECGKAFSYLSNLNQHQKTHTQEKAYECKECGKAFIRSSSLAKHERIHTGEKPYQCHECGKTFSYGSSLIQHRKIHTGERPYKCNECGRAFNQNIHLTQHKRIHTGAKPYECAECGKAFRHCSSLAQHQKTHTEEKPYHCNKCEKAFSQSSHLAQHQRIHTGEKPYKCNECDKTFSRSTHLTEHQNTHTGEKPYNCNECRKTFSQSTYLIQHQRIHSAEKPFGCNDCGKAFRYRSALNKHQRLHPGI", "length": 752, "header": "sp|A6QLU5-1|ZN184_BOVIN Isoform 1 of Zinc finger protein 184 OS=Bos taurus OX=9913 GN=ZNF184 PE=2 SV=1 CANONICAL=A6QLU5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 117, "end_pos": 117, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QLU5", "url": "https://www.uniprot.org/uniprotkb/A6QLU5" } ], "site_lbl": "Ser117" }, { "start_pos": 122, "end_pos": 122, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QLU5", "url": "https://www.uniprot.org/uniprotkb/A6QLU5" } ], "site_lbl": "Ser122" }, { "start_pos": 200, "end_pos": 200, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QLU5", "url": "https://www.uniprot.org/uniprotkb/A6QLU5" } ], "site_lbl": "Ser200" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515674", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515674", "resource": "KEGG Pathway" } ], 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"glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AP5M1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X5", "locus": { "chromosome": "10", "start_pos": 69693761, "end_pos": 69671251, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013043", "url": "https://www.ensembl.org/id/ENSBTAG00000013043" } ] } } ], "crossref": [ { "id": "Q5E9X5", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9X5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013043", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013043", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09256", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09256", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539663", "url": "https://www.ncbi.nlm.nih.gov/gene/539663", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028565", "url": 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] }, { "id": "PTHR16082:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16082:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00928", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00928", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015670", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S603", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S603", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S603-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S603-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU5-1", "database": "UniProtKB", "categories": [ 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"https://www.uniprot.org/uniprotkb/Q5E9X5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQRAVWLISHESGTPLGGIVKFSRRYPTVEKRAKVFNGASYVPVPEDGPFLKALLFELRLLDDEKDFLESRDSCSHINKTSIYGVPVGGEELWPVVAFLKNGMIYACVPLVEQTLSPRPPLISISGISQGFELLFGVQDFLSSGQKTDSELNTKLSQLSDLLLQTCPFGTLLDANLQNSLDSINSASVTHLQKQPAWKTGTYKGKPQVSISITEKVNSMQYDKQEIADTWQVVGVVTCKCDLEGSMPNVTISLSLPTNGSPLQDILVHPCVTSLDSAILTSSSIDAMDDSAFSGPYKFPLTPPLESFNLCYYTSQVPVPPILGFYQVKEEEVQLKITVNLKLHESVKNSFEFCEAHIPFYNRGPITHVEYKASFGQLEVFREKSLLVWIIGQKFPKSMEISLSGTITFGAKNHEKQPFDQICIGGTAYLKLHFRILDYTLTGCYVDQHSVQVFASGKPKISTYRKLISSDYYIWNSKAPAPVTYGSLLL", "length": 490, "header": "sp|Q5E9X5-1|AP5M1_BOVIN Isoform 1 of AP-5 complex subunit mu-1 OS=Bos taurus OX=9913 GN=AP5M1 PE=2 SV=1 CANONICAL=Q5E9X5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S603-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X5/entry#A0AAA9S603-1", "sequence": { "sequence": "MAQRAVWLISHESGTPLGGIVKFSRRYPTVEKRAKVFNGASYVPVPEDGPFLKALLFELRLLDDEKDFLESRDSCSHINKTSIYGVPVGGEELWPVVAFLKNGMIYACVPLVEQTLSPRPPLISISGISQGFELLFGVQDFLSSGQKTDSELNTKLSQLSDLLLQTCPFGTLLDANLQNSLDSINSASVTHLQKQPAWKTGTYKGKPQVSISITEKVNSMQYDKQEIADTWQVVGVVTCKCDLEGSMPNVTISLSLPTNGSPLQDILVHPCVTSLDSAILTSSSIDAMDDSAFSGPYKFPLTPPLESFNLCYYTSQVPVPPILGFYQVKEEEVQLKITVNLKLHESVKNSFEFCEAHIPFYNRGPITHVEYKASFGQLEVFREKSLLVWIIGQKFPKSMEISLSGTITFGAKNHEKQPFDQICIGGTAYLKLHFRILDYTLTGCYVDQHSVQVFASGKPKISTYRKLISSDYYIWNSKAPAPVTYGSLLLNLSLQDNF", "length": 498, "header": "tr|A0AAA9S603-1|AP5M1_BOVIN Computationally mapped isoform of AP-5 complex subunit mu-1 OS=Bos taurus OX=9913 GN=AP5M1 PE=2 SV=1 CANONICAL=Q5E9X5-1" }, "locus": { "chromosome": "10", "start_pos": 69692579, "end_pos": 69671500, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132351.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132351.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081368.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081368.1" } ] } }, { "isoform_ac": "A0AAA9TFU5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X5/entry#A0AAA9TFU5-1", "sequence": { "sequence": "MAQRAVWLISHESGTPLGGIVKFSRRYPTVEKRAKVFNGASYVPVPEDGPFLKALLFELRLLDDEKDFLESRDSCSHINKTSIYGVPVGGEELWPVVAFLKNGMIYACVPLVEQTLSPRPPLISISGISQGFELLFGVQDFLSSGQKTDSELNTKLSQLSDLLLQTCPFGTLLDANLQNSLDSINSASVTHLQKQPAWKTGTYKGKPQVSISITEKVNSMQYDKQEIADTWQVVGVVTCKCDLEGSMPNVTISLSLPTNGSPLQDILVHPCVTSLDSAILTSSSIDAMDDSAFSGPYKFPLTPPLESFNLCYYTSQVPVPPILGFYQVKEEEVQLKITVNLKLHESVKNSFEFCEAHIPFYNRGPITHVEYKASFGQLEVFREKSLLVWIIGQKFPKSMEISLSGTITFGAKNHEKQPFDQICIGGTAYLKSKEERQEMREIFRKRRRKKKV", "length": 452, "header": "tr|A0AAA9TFU5-1|AP5M1_BOVIN Computationally mapped isoform of AP-5 complex subunit mu-1 OS=Bos taurus OX=9913 GN=AP5M1 PE=2 SV=1 CANONICAL=Q5E9X5-1" }, "locus": { "chromosome": "10", "start_pos": 69686566, "end_pos": 69671500, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104214.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104214.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095890.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095890.1" } ] } }, { "isoform_ac": "A0AAA9TNW9-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X5/entry#A0AAA9TNW9-1", "sequence": { "sequence": "MAQRAVWLISHESGTPLGGIVKFSRRYPTVEKRAKVFNGASYVPVPEDGPFLKALLFELRLLDDEKDFLESRDSCSHINKTSIYGVPVGGEELWPVVAFLKNGMIYACVPLVEQTLSPRPPLISISGISQGFELLFGVQDFLSSGQKTDSELNTKLSQLSDLLLQTCPFGTLLDANLQNSLDSINSASVTHLQKQPAWKTGTYKGKPQVSISITEKVNSMQYDKQEIADTWQVVGVVTCKCDLEGSMPNVTISLSLPTNGSPLQDILVHPCVTSLDSAILTSSSIDAMDDSAFSGPYKFPLTPPLESFNLCYYTSQVPVPPILGFYQVKEEEVQLKITVNLKLHESVKNSFEFCEAHIPFYNRGPITHVEYKASFGQLEVFREKSLLVWIIGQKFPKSMEISLSGTITFGAKNHEKQPFDQICIGGTAYLKLHFRILDYTLTGCYVDQHSVQVFASGKPKISTYRKLISSDYYIWNSKAPAPVTYGSLLLVRCHN", "length": 495, "header": "tr|A0AAA9TNW9-1|AP5M1_BOVIN Computationally mapped isoform of AP-5 complex subunit mu-1 OS=Bos taurus OX=9913 GN=AP5M1 PE=2 SV=1 CANONICAL=Q5E9X5-1" }, "locus": { "chromosome": "10", "start_pos": 69692757, "end_pos": 69671500, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089309.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089309.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098744.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098744.1" } ] } }, { "isoform_ac": "A0AAA9TZT3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X5/entry#A0AAA9TZT3-1", "sequence": { "sequence": "MAQRAVWLISHESGTPLGGIVKFSRRYPTVEKRAKVFNGASYVPVPEDGPFLKALLFELRLLDDEKDFLESRDSCSHINKTSIYGVPVGGEELWPVVAFLKNGMIYACVPLVEQTLSPRPPLISISGISQGFELLFGVQDFLSSGQKTDSELNTKLSQLSDLLLQTCPFGTLLDANLQNSLDSINSASVTHLQKQPAWKTGTYKGKPQVSISITEKVNSMQYDKQEIADTWQVVGVVTCKCDLEGSMPNVTISLSLPTNGSPLQDILVHPCVTSLDSAILTSSSIDAMDDSAFSGPYKFPLTPPLESFNLCYYTSQVPVPPILGFYQVKEEEVQLKITVNLKLHESVKNSFEFCEAHIPFYNRGPITHVEYKASFGQLEVFREKSLLVWIIGQKFPKSMEISLSGTITFGAKNHEKQPFDQICIGGTAYLKLHFRILDYTLTGCYVDQHSVQVFASGKPKISTYRKLISSDYYIWNSKAPAPVTYGSLLLASSCGRHG", "length": 498, "header": "tr|A0AAA9TZT3-1|AP5M1_BOVIN Computationally mapped isoform of AP-5 complex subunit mu-1 OS=Bos taurus OX=9913 GN=AP5M1 PE=2 SV=1 CANONICAL=Q5E9X5-1" }, "locus": { "chromosome": "10", "start_pos": 69690963, "end_pos": 69671500, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088480.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088480.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103846.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103846.1" } ] } }, { "isoform_ac": "A0AAF6YYH7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X5/entry#A0AAF6YYH7-1", "sequence": { "sequence": "MAQRAVWLISHESGTPLGGIVKFSRRYPTVEKRAKVFNGASYVPVPEDGPFLKALLFELRLLDDEKDFLESRDSCSHINKTSIYGVPVGGEELWPVVAFLKNGMIYACVPLVEQTLSPRPPLISISGISQGFELLFGVQDFLSSGQKTDSELNTKLSQLSDLLLQTCPFGTLLDANLQNSLDSINSASVTHLQKQPAWKTGTYKGKPQVSISITEKVNSMQYDKQEIADTWQVVGVVTCKCDLEGSMPNVTISLSLPTNGSPLQDILVHPCVTSLDSAILTSSSIDAMDDSAFSGPYKFPLTPPLESFNLCYYTSQNLEEENLDKQEEEEECITHLCKVPVPPILGFYQVKEEEVQLKITVNLKLHESVKNSFEFCEAHIPFYNRGPITHVEYKASFGQLEVFREKSLLVWIIGQKFPKSMEISLSGTITFGAKNHEKQPFDQICIGGTAYLKLHFRILDYTLTGCYVDQHSVQVFASGKPKISTYRKLISSDYYIWNSKAPAPVTYGSLLL", "length": 512, "header": "tr|A0AAF6YYH7-1|AP5M1_BOVIN Computationally mapped isoform of AP-5 complex subunit mu-1 OS=Bos taurus OX=9913 GN=AP5M1 PE=2 SV=1 CANONICAL=Q5E9X5-1" }, "locus": { "chromosome": "10", "start_pos": 69690629, "end_pos": 69671500, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017337.5", "url": "https://www.ensembl.org/id/ENSBTAT00000017337.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017337.3", "url": "https://www.ensembl.org/id/ENSBTAP00000017337.3" } ] } }, { "isoform_ac": "Q5E9X5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X5/entry#Q5E9X5-1", "sequence": { "sequence": "MAQRAVWLISHESGTPLGGIVKFSRRYPTVEKRAKVFNGASYVPVPEDGPFLKALLFELRLLDDEKDFLESRDSCSHINKTSIYGVPVGGEELWPVVAFLKNGMIYACVPLVEQTLSPRPPLISISGISQGFELLFGVQDFLSSGQKTDSELNTKLSQLSDLLLQTCPFGTLLDANLQNSLDSINSASVTHLQKQPAWKTGTYKGKPQVSISITEKVNSMQYDKQEIADTWQVVGVVTCKCDLEGSMPNVTISLSLPTNGSPLQDILVHPCVTSLDSAILTSSSIDAMDDSAFSGPYKFPLTPPLESFNLCYYTSQVPVPPILGFYQVKEEEVQLKITVNLKLHESVKNSFEFCEAHIPFYNRGPITHVEYKASFGQLEVFREKSLLVWIIGQKFPKSMEISLSGTITFGAKNHEKQPFDQICIGGTAYLKLHFRILDYTLTGCYVDQHSVQVFASGKPKISTYRKLISSDYYIWNSKAPAPVTYGSLLL", "length": 490, "header": "sp|Q5E9X5-1|AP5M1_BOVIN Isoform 1 of AP-5 complex subunit mu-1 OS=Bos taurus OX=9913 GN=AP5M1 PE=2 SV=1 CANONICAL=Q5E9X5-1" }, "locus": { "chromosome": "10", "start_pos": 69690629, "end_pos": 69671500, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153493.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153493.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104098.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104098.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X5", "url": "https://www.uniprot.org/uniprotkb/Q5E9X5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:539663", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539663", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B4H1-1", "protein_name": "AP-5 complex subunit mu-1", "gene_name": "AP5M1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAQRAVWLISHEPGTSPCGTIKFSRRYPTVEKRAKVFNGASYVPVPEDGPFLKALLFELRLLDDDKDFAESRDSCSHIRKTSIYGLPVGSEELWPVVAFLKNGMIYACVPLVEQTLSPHPPLISICGISQGFELLFGLQDFLYSGQKNDTDVNTKVSQLPDLLLQSCPFGTLLDANLQNSLDSINFTSVTHPQKQPAWKAGMYKGKPQVSISITEKVKSMQYDKQDIADTWQVVGAVTCKCDLEGSMPNVTISLSLPTNGSPLQDILVHPCVTSLDSAILTSSSIDPMDDSAFSGPYKFPLTPPLESFNLCYYTSQVPVPPILGFYQVKEEGVQLKITVNLKLHESVKNSFEFCEAHIPFYNRGPITHVEYKVSFGQIEVFREKSLLVWIIGQKFPKSMEISLSGTVTFGAKSHEKQPFDHICIGGTAYLKLHFRILDYTLTGCYADQHSVQVFASGKPKISTHRKLISSDYYIWNSKAPAPITYGSLLL", "length": 490 }, "evidence": [ { "id": "Q5E9X5", "url": "https://omabrowser.org/oma/group/Q5E9X5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Z1H8-1", "protein_name": "AP-5 complex subunit mu-1", "gene_name": "AP5M1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MALRALWVLRHEPRAVLFSRRYPTVEARAEAFNGSTHVAVPSDSDFLKAMLFELRLTDDQSFVEHRDTCTRIDHSSVRSVRVEGGDLWPVVAFQKSGLIYACLPLVEEALEPRPSLLTIPGLSQGLALLFGILDYISPSRKNEAELSAKAGQLRTLIIQACPLGTPLNTNISSLSSSFDDIQVVPTDVKQPAWRSNTYKGKPQVNVCITEKVKCMQYDKRDVVDMWQVYGAVNCKCDIEGAAPNVTLTLNLPTNGSPLQDIFVHHCVTSVDPAMLMSSSVNPLDDSVYSGPYKFPFIPPSESFNLCYYTSQVPVPPILGCYQLIEEGSQLKITVNLKLHESIKNSFEYCEARIPFFNRGPIAHLECKVSYGQLDLSREKSLLVWVIGQKFPKSSEVSLTGTVTFGDIGEEHPTNYVCTGNTAYVKMYFRIPDFTLTGCYVDQHSVQIFTPGKPKITASRELISSDYYIWNSKASAPTMYKSLYY", "length": 484 }, "evidence": [ { "id": "Q5E9X5", "url": "https://omabrowser.org/oma/group/Q5E9X5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q499N2-1", "protein_name": "AP-5 complex subunit mu-1", "gene_name": "Ap5m1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALRAVWLIRHEPGTPLGGTVKFSRRYPTVEKRAKVFNGMNYVPVPEDGPFLKALLFQLRLLDDDKDFVESRDSCSNINKTSIYGLSVGGEDLWPVIAFLRNDMIYASVPLVEQALSPRPPLISISGVSQGLELLLGVHDFLYSSQKNDTDLHSRLSQLPDLLLQACPLGTLLDANLQNSLNSLNFVSVTQPQKQPAWKVGTYKGKAQISISITENVKSMQYGKQDIADTWQVVGTVACKCDLEGVMPNVTISLNLPTNGSPLQDIIVHPCVTSLDSAILTSSSIDTVDDSAFSGPYKFPFTPPLESFNLCHYTSQVPVPPILGSYHMKEDGAQLKITVNLKLHESVRNNFEICEAHIPFYNRGPITHLEYKVSFGQLEVFREKSLLVWIIGQKFPKSMEISLSGTLTFRVQGHNRQPFDHICIGSTAYVKLNFRIADYTLTGCYADQHSVQVFASGKPKISAYRKLISSDYYIWNSKASAPVTYASLLP", "length": 490 }, "evidence": [ { "id": "Q5E9X5", "url": "https://omabrowser.org/oma/group/Q5E9X5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q54NP5-1", "protein_name": "MHD domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MCTLRALWVLKENSNGGTEIILSKRINTVENRVRALSGSNYNPIPIDSELIALFNTELIKDSQGYSTGQTSPISLQQQQQTPLQTQTSSSLLSASMASKQQNQQTTTTITNLNSSALSLVKVYTNTPNTHVISLNQERLWPFIYIKKKNLYFITIPVIEEFLVSNRKPSLIDLPSITAALNFLEETSIYMIGFLNKPPPYPELQVFLTNIIPFGQPIDTNFNNVKAMIRQGFPSVETFQQKRPAWKPFLHKGKQQLDFIISETIQCILYDNPSIPDVSKVSGSLICKADLEGMPEVSFYLQPTIAATGSGVGGIIGQNEPVITNLAIDSTVQTTSDININNKISFFNPPLDHFKLLSYGVQGIKAVPLRGFYQMKETSANSIKVLIQLKLNSEMNNSFDYCLLKIPFKNRSNIIQVNASPTTGSIFIDHSLKAIIWNIGQKFTGRNLEVALPMEIVFSSVPTNLIPQPPPQPPTLIVSSSSGNQNVTAFPKQDQSFPIIDSSPSDQEDCYSPDPFCTGSNSFVRIYFKIQNCTLSGLNIDPKKVVIYPTNKFKLNIEREVLSSEYIIWNSLGSSKYSYQPSSSSK", "length": 585 }, "evidence": [ { "id": "Q5E9X5", "url": "https://omabrowser.org/oma/group/Q5E9X5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8BJ63-1", "protein_name": "AP-5 complex subunit mu-1", "gene_name": "Ap5m1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALRAVWLIRHEPGTPLGGTVRFSRRYPTVEKRAKAFNGMTYVPVPEDGPFLRALLFQLRLLDDDKDFMERRDGCSRINKTSIYGLSVGGEELWPVIAFLRDSMIYASVPLVEQALSPRPPLISISGVSQGLELLLGIQDFLYSSQKNDTDLHTKLSQLPDLLLQACPLGTLLDANLQNSLNSINSVSVTQPQKQPAWKVGAYKGKAQISISITETVKCMQYGKQDIADTWQVAGTVACKCDLEGVMPAVTISLSLPTNGSPLQDIIVHPCVTSLDSAILTSSSIDTMDDSAFSGPYKFPFTPPLESFNLCHYTSQVPVPPILGSYHMKEEGVQLKVTVNFKLHESVRNNFEVCEAHIPFYNRGPITHLEYKASFGQLEVFREKSLLVWIIGQKFPKSMEISLSGTLTFGVKGHNKQPFDHICIGNTAYIKLNFRIADYTLTGCYADQHSVQVFASGKPKISAYRKLISSDYYIWNSKAPAPVTYASLLP", "length": 490 }, "evidence": [ { "id": "Q5E9X5", "url": "https://omabrowser.org/oma/group/Q5E9X5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H0R1-1", "protein_name": "AP-5 complex subunit mu-1", "gene_name": "AP5M1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQRAVWLISHEPGTPLCGTVRFSRRYPTVEKRARVFNGASYVPVPEDGPFLKALLFELRLLDDDKDFVESRDSCSRINKTSIYGLLIGGEELWPVVAFLKNDMIYACVPLVEQTLSPRPPLISVSGVSQGFEFLFGIQDFLYSGQKNDSELNTKLSQLPDLLLQACPFGTLLDANLQNSLDNTNFASVTQPQKQPAWKTGTYKGKPQVSISITEKVKSMQYDKQGIADTWQVVGTVTCKCDLEGIMPNVTISLSLPTNGSPLQDILVHPCVTSLDSAILTSSSIDAMDDSAFSGPYKFPFTPPLESFNLCFYTSQVPVPPILGFYQMKEEEVQLRITINLKLHESVKNNFEFCEAHIPFYNRGPITHLEYKTSFGQLEVFREKSLLIWIIGQKFPKSMEISLSGTVTFGAKSHEKQPFDPICTGETAYLKLHFRILDYTLTGCYADQHSVQVFASGKPKISAHRKLISSDYYIWNSKAPAPVTYGSLLL", "length": 490 }, "evidence": [ { "id": "Q5E9X5", "url": "https://omabrowser.org/oma/group/Q5E9X5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X5", "url": "https://www.uniprot.org/uniprotkb/Q5E9X5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X5", "url": "https://www.uniprot.org/uniprotkb/Q5E9X5" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X5", "url": "https://www.uniprot.org/uniprotkb/Q5E9X5" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X5", "url": "https://www.uniprot.org/uniprotkb/Q5E9X5" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X5", "url": "https://www.uniprot.org/uniprotkb/Q5E9X5" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X5", "url": "https://www.uniprot.org/uniprotkb/Q5E9X5" } ], "pmid": "" }, { "name": "AP-type membrane coat adaptor complex", "id": "GO:0030119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030119", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X5", "url": "https://www.uniprot.org/uniprotkb/Q5E9X5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X5", "url": "https://www.uniprot.org/uniprotkb/Q5E9X5" } ], "pmid": "" }, { "name": "endosomal transport", "id": "GO:0016197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016197", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X5", "url": "https://www.uniprot.org/uniprotkb/Q5E9X5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], 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"ENSBTAP00000095522.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095522.1" } ] } }, { "isoform_ac": "A0AAA9TG86-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIN6/entry#A0AAA9TG86-1", "sequence": { "sequence": "MAFTFAAFCYMLALLLTAALIFFAIWHLVLPEYLIHAFFCVMFLCAAEWLTLGLNMPLLAYHIWRYMSRPVMSGPGLYDPTTIMNADILAYCQKEGWCKLAFYLLAFFYYLYGMIYVLVSS", "length": 121, "header": "tr|A0AAA9TG86-1|CNIH1_BOVIN Computationally mapped isoform of Protein cornichon homolog 1 OS=Bos taurus OX=9913 GN=CNIH1 PE=2 SV=1 CANONICAL=Q5BIN6-1" }, "locus": { "chromosome": "10", "start_pos": 66961753, "end_pos": 66948040, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105646.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105646.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095187.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095187.1" } ] } }, { "isoform_ac": "A0AAA9TYK4-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIN6/entry#A0AAA9TYK4-1", "sequence": { 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Computationally mapped isoform of Protein cornichon homolog 1 OS=Bos taurus OX=9913 GN=CNIH1 PE=2 SV=1 CANONICAL=Q5BIN6-1" }, "locus": { "chromosome": "10", "start_pos": 66961753, "end_pos": 66948040, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025975.5", "url": "https://www.ensembl.org/id/ENSBTAT00000025975.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025975.4", "url": "https://www.ensembl.org/id/ENSBTAP00000025975.4" } ] } }, { "isoform_ac": "G8JKZ7-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIN6/entry#G8JKZ7-1", "sequence": { "sequence": "MAFTFAAFCYMLALLLTAALIFFAIWHIIAFDELKTDYKNPIDQCNTLNPLVLPEYLIHAFFCVMFLCAAEWLTLGLNMPLLAYHIWRYMSRPVMSGPGLYDPTTIMNADILAYCQKEGWCKLAFYLLAFFYYLYGAVLLCK", "length": 142, "header": "tr|G8JKZ7-1|CNIH1_BOVIN Computationally mapped isoform of Protein cornichon homolog 1 OS=Bos taurus OX=9913 GN=CNIH1 PE=2 SV=3 CANONICAL=Q5BIN6-1" }, "locus": { "chromosome": "10", "start_pos": 66961753, "end_pos": 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"https://www.reactome.org/PathwayBrowser/#R-BTA-380259", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380270", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380284", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380284", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380320", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5620912", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6807878", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8854518", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029730", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSJ7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSJ7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCA4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCA4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCA4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFN7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCP2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCP2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPU3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPU3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TU41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TU41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YVK6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVK6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YVK6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVK6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCF0", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCF0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELTSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQLEATKNSKGTGSGGKTTSGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSAGLQGACLMDTVELLQAKVGALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQSKVHQLYETIQRWSPIAASLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMIACSLKDNATLLTQVQTTMCENLSTIEGNFANIDERMKKLGK", "length": 403, "header": "sp|Q3ZCF0-1|DCTN2_BOVIN Isoform 1 of Dynactin subunit 2 OS=Bos taurus OX=9913 GN=DCTN2 PE=2 SV=1 CANONICAL=Q3ZCF0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSJ7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF0/entry#A0A3Q1LSJ7-1", "sequence": { "sequence": "MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELTSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQLEATKNSKGTGSGGKTTSGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSAGLQGACLMDTVELLQAKVGALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQSKVHQLYETIQRWSPIAASLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMIACSLKDNATLLTQSQLGFILPGSSTRCS", "length": 390, "header": "tr|A0A3Q1LSJ7-1|DCTN2_BOVIN Computationally mapped isoform of Dynactin subunit 2 OS=Bos taurus OX=9913 GN=DCTN2 PE=2 SV=2 CANONICAL=Q3ZCF0-1" }, "locus": { "chromosome": "5", "start_pos": 55945761, "end_pos": 55933428, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074452.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074452.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063350.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063350.2" } ] } }, { "isoform_ac": "A0A3Q1MCA4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF0/entry#A0A3Q1MCA4-1", "sequence": { "sequence": "MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAELEELTSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQLEATKNSKGTGSGGKTTSGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSAGLQGACLMDTVELLQAKVGALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQSKVHQLYETIQRWSPIAASLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMIACSLKDNATLLTQVQTTMCENLSTIEGNFANIDERMKKLGK", "length": 405, "header": "tr|A0A3Q1MCA4-1|DCTN2_BOVIN Computationally mapped isoform of Dynactin subunit 2 OS=Bos taurus OX=9913 GN=DCTN2 PE=2 SV=2 CANONICAL=Q3ZCF0-1" }, "locus": { "chromosome": "5", "start_pos": 55946528, "end_pos": 55933428, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067198.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067198.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066387.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066387.2" } ] } }, { "isoform_ac": "A0AAA9SFN7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF0/entry#A0AAA9SFN7-1", "sequence": { "sequence": "MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELTSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQLEATKNSKGTGSGGKTTSGTPPDSSLVTYELHSRPEQDKFSQAAKNPLSAGLQGACLMDTVELLQAKVGALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQSKVHQLYETIQRWSPIAASLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMIACSLKDNATLLTQVQTTMCENLSTIEGNFANIDERMKKLGK", "length": 381, "header": "tr|A0AAA9SFN7-1|DCTN2_BOVIN Computationally mapped isoform of Dynactin subunit 2 OS=Bos taurus OX=9913 GN=DCTN2 PE=2 SV=1 CANONICAL=Q3ZCF0-1" }, "locus": { "chromosome": "5", "start_pos": 55946528, "end_pos": 55933428, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127687.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127687.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082423.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082423.1" } ] } }, { "isoform_ac": "A0AAA9TCP2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF0/entry#A0AAA9TCP2-1", "sequence": { "sequence": "MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAFAQELEELTSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQLEATKNSKGTGSGGKTTSGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSAGLQGACLMDTVELLQAKVGALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQSKVHQLYETIQRWSPIAASLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMIACSLKDNATLLTQVQTTMCENLSTIEGNFANIDERMKKLGK", "length": 408, "header": "tr|A0AAA9TCP2-1|DCTN2_BOVIN Computationally mapped isoform of Dynactin subunit 2 OS=Bos taurus OX=9913 GN=DCTN2 PE=2 SV=1 CANONICAL=Q3ZCF0-1" }, "locus": { "chromosome": "5", "start_pos": 55946528, "end_pos": 55933428, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112899.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112899.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094511.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094511.1" } ] } }, { "isoform_ac": "A0AAA9TPU3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF0/entry#A0AAA9TPU3-1", "sequence": { "sequence": "MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELTSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQLEATKNSKGTGSGGKTTSGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSAGLQGACLMDTVELLQAKVGALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQSKVHQLYETIQRWSPIAASLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMIACSLKDNATLLTQVQTTMCENLSTIEGNFANIDERMKKLGKPQG", "length": 406, "header": "tr|A0AAA9TPU3-1|DCTN2_BOVIN Computationally mapped isoform of Dynactin subunit 2 OS=Bos taurus OX=9913 GN=DCTN2 PE=2 SV=1 CANONICAL=Q3ZCF0-1" }, "locus": { "chromosome": "5", "start_pos": 55946739, "end_pos": 55933428, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115186.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115186.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100414.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100414.1" } ] } }, { "isoform_ac": "A0AAA9TU41-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF0/entry#A0AAA9TU41-1", "sequence": { "sequence": "MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELTSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQLEATKNSKGTGSGGKTTSGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSAGLQGACLMDTVELLQAKVGALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQSKFGQLLTHLDTTQQMIACSLKDNATLLTQVQTTMCENLSTIEGNFANIDERMKKLGK", "length": 366, "header": "tr|A0AAA9TU41-1|DCTN2_BOVIN Computationally mapped isoform of Dynactin subunit 2 OS=Bos taurus OX=9913 GN=DCTN2 PE=2 SV=1 CANONICAL=Q3ZCF0-1" }, "locus": { "chromosome": "5", "start_pos": 55946528, "end_pos": 55933428, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089740.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089740.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101888.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101888.1" } ] } }, { "isoform_ac": "A0AAF6YVK6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF0/entry#A0AAF6YVK6-1", "sequence": { "sequence": "MADPKYADLPGIEELTSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQLEATKNSKGTGSGGKTTSGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSAGLQGACLMDTVELLQAKVGALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQSKVHQLYETIQRWSPIAASLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMIACSLKDNATLLTQVQTTMCENLSTIEGNFANIDERMKKLGK", "length": 380, "header": "tr|A0AAF6YVK6-1|DCTN2_BOVIN Computationally mapped isoform of Dynactin subunit 2 OS=Bos taurus OX=9913 GN=DCTN2 PE=2 SV=1 CANONICAL=Q3ZCF0-1" }, "locus": { "chromosome": "5", "start_pos": 55946528, "end_pos": 55933428, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014053.6", "url": "https://www.ensembl.org/id/ENSBTAT00000014053.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014053.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014053.5" } ] } }, { "isoform_ac": "Q3ZCF0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF0/entry#Q3ZCF0-1", "sequence": { "sequence": "MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELTSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQLEATKNSKGTGSGGKTTSGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSAGLQGACLMDTVELLQAKVGALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQSKVHQLYETIQRWSPIAASLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMIACSLKDNATLLTQVQTTMCENLSTIEGNFANIDERMKKLGK", "length": 403, "header": "sp|Q3ZCF0-1|DCTN2_BOVIN Isoform 1 of Dynactin subunit 2 OS=Bos taurus OX=9913 GN=DCTN2 PE=2 SV=1 CANONICAL=Q3ZCF0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 134, "end_pos": 134, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF0", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF0" } ], "site_lbl": "Thr134" }, { "start_pos": 200, "end_pos": 200, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF0", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF0" } ], "site_lbl": "Thr200" }, { "start_pos": 322, "end_pos": 322, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF0", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF0" } ], "site_lbl": "Ser322" }, { "start_pos": 6, "end_pos": 6, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF0", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF0" } ], "site_lbl": "Tyr6" }, { "start_pos": 83, "end_pos": 83, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF0", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF0" } ], "site_lbl": "Ser83" }, { "start_pos": 86, "end_pos": 86, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF0", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF0" } ], "site_lbl": "Tyr86" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:527201", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527201", "resource": "KEGG Pathway" }, { "id": "R-BTA-2132295", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "resource": "Reactome", "description": "MHC class II antigen presentation" }, { "id": "R-BTA-2565942", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2565942", "resource": "Reactome", "description": "Regulation of PLK1 Activity at G2/M Transition" }, { "id": "R-BTA-3371497", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371497", "resource": "Reactome", "description": "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" }, { "id": "R-BTA-380259", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380259", "resource": "Reactome", "description": "Loss of Nlp from mitotic centrosomes" }, { "id": "R-BTA-380270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "resource": "Reactome", "description": "Recruitment of mitotic centrosome proteins and complexes" }, { "id": "R-BTA-380284", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380284", "resource": "Reactome", "description": "Loss of proteins required for interphase microtubule organization from the centrosome" }, { "id": "R-BTA-380320", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "resource": "Reactome", "description": "Recruitment of NuMA to mitotic centrosomes" }, { "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" }, { "id": "R-BTA-6807878", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "resource": "Reactome", "description": "COPI-mediated anterograde transport" }, { "id": "R-BTA-6811436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811436", "resource": "Reactome", "description": "COPI-independent Golgi-to-ER retrograde traffic" }, { "id": "R-BTA-8854518", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "resource": "Reactome", "description": "AURKA Activation by TPX2" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 10, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": 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"categories": [ "Genome Annotation" ] }, { "id": "IPR000649", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000649", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037171", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037171", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042529", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042529", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513958", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513958", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SHSCAVA", "url": "https://omabrowser.org/oma/group/SHSCAVA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9B4", "url": "https://www.orthodb.org/?gene=Q5E9B4", "database": 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"MPGAAAKGSELSERIESFVEALKRGGGRRSSEDMARETLGLLRRIITDHRWSNAGELMELIRREGRRMTAAQPSETTVGNMVRRVLRIIREEYGRLHGRSDESDQQESLHKLLTSGGLSEDFRSHYAQLQSNIIEAINELLVELEGTTENIAAQALEHIHSNEVIMTIGFSRTVEAFLREAARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAVAGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL", "length": 351, "header": "sp|Q5E9B4-1|EI2BB_BOVIN Isoform 1 of Translation initiation factor eIF2B subunit beta OS=Bos taurus OX=9913 GN=EIF2B2 PE=2 SV=1 CANONICAL=Q5E9B4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQ43-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9B4/entry#A0AAA9SQ43-1", "sequence": { "sequence": "MPGAAAKGSELSERIESFVEALKRGGGRRSSEDMARETLGLLRRIITDHRWSNAGELMELIRREGRRMTAAQPSETTVGNMVRRVLRIIREEYGRLHGRSDESDQQESLHKLLTSGGLSEDFRSHYAQLQSNIIEAINELLVELEGTTENIAAQALEHIHSNEVIMTIGFSRTVEAFLREAARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAVAGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEENRLKACELGGCCTRTRLPLSHGIFPDQGLNPCPLPWQADS", "length": 340, "header": "tr|A0AAA9SQ43-1|EI2BB_BOVIN Computationally mapped isoform of Translation initiation factor eIF2B subunit beta OS=Bos taurus OX=9913 GN=EIF2B2 PE=2 SV=1 CANONICAL=Q5E9B4-1" }, "locus": { "chromosome": "10", "start_pos": 86274824, "end_pos": 86259569, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093206.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093206.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087492.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087492.1" } ] } }, { "isoform_ac": "A0ABI0NK85-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9B4/entry#A0ABI0NK85-1", "sequence": { "sequence": "MPGAAAKGSELSERIESFVEALKRGGGRRSSEDMARETLGLLRRIITDHRWSNAGELMELIRREGRRMTAAQPSETTVGNMVRRVLRIIREEYGRLHGRSDESDQQESLHKLLTSGGLSEDFRSHYAQLQSNIIEAINELLVELEGTTENIAAQALEHIHSNEVIMTIGFSRTVEAFLREAARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKLLQLCPTLCDPIDSSPPGSLVPGILQARTLEWVIIGTKTILANGALRAVAGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL", "length": 383, "header": "tr|A0ABI0NK85-1|A0ABI0NK85_BOVIN Computationally mapped isoform of Translation initiation factor eIF2B subunit beta OS=Bos taurus OX=9913 GN=EIF2B2 PE=3 SV=1 CANONICAL=Q5E9B4-1" }, "locus": { "chromosome": "10", "start_pos": 86266157, "end_pos": 86259569, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154123.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154123.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105041.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105041.1" } ] } }, { "isoform_ac": "A0ABI0NXS5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9B4/entry#A0ABI0NXS5-1", "sequence": { "sequence": "MPGAAAKGSELSERIESFVEALKRGGGRRSSEDMARETLGLLRRIITDHRWSNAGELMELIRREGRRMTAAQPSETTVGNMVRRVLRIIREEYGRLHGRSDESDQQESLHKLLTSGGLSEDFRSHYAQLQSNIIEAINELLVELEGTTENIAAQALEHIHSNEVIMTIGFSRTVEAFLREAARKRKFHVIVAECAPFCQVIIGTKTILANGALRAVAGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL", "length": 319, "header": "tr|A0ABI0NXS5-1|A0ABI0NXS5_BOVIN Computationally mapped isoform of Translation initiation factor eIF2B subunit beta OS=Bos taurus OX=9913 GN=EIF2B2 PE=3 SV=1 CANONICAL=Q5E9B4-1" }, "locus": { "chromosome": "10", "start_pos": 86266157, "end_pos": 86259569, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000148739.1", "url": "https://www.ensembl.org/id/ENSBTAT00000148739.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104603.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104603.1" } ] } }, { "isoform_ac": "Q5E9B4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9B4/entry#Q5E9B4-1", "sequence": { "sequence": "MPGAAAKGSELSERIESFVEALKRGGGRRSSEDMARETLGLLRRIITDHRWSNAGELMELIRREGRRMTAAQPSETTVGNMVRRVLRIIREEYGRLHGRSDESDQQESLHKLLTSGGLSEDFRSHYAQLQSNIIEAINELLVELEGTTENIAAQALEHIHSNEVIMTIGFSRTVEAFLREAARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAVAGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL", "length": 351, "header": "sp|Q5E9B4-1|EI2BB_BOVIN Isoform 1 of Translation initiation factor eIF2B subunit beta OS=Bos taurus OX=9913 GN=EIF2B2 PE=2 SV=1 CANONICAL=Q5E9B4-1" }, "locus": { "chromosome": "10", "start_pos": 86266157, "end_pos": 86259569, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154689.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154689.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104502.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104502.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B4", "url": "https://www.uniprot.org/uniprotkb/Q5E9B4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:513958", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513958", "resource": "KEGG Pathway" }, { "id": "R-BTA-72731", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72731", "resource": "Reactome", "description": "Recycling of eIF2:GDP" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XRM9-1", "protein_name": "Translation initiation factor eIF2B subunit beta", "gene_name": "EIF2B2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPGAAERGSELSEQIEAFVSRLRGGGQRPRSEDTARQTLSLLRKIIAHGRWGWAGELMDLIRTEGRRMTAAQPSETTVGNMVRRVLKVIREEYGRLHGRSEESDQQDSLHKLLTSGGLSEDFSTPYPSLRANVIEAINELLIELEGTTDNIAMQALEHIHSNEVIMTIGYSRTVEAFLKEAARKRKFQVIVAECAPFCQGHEMAVRLSKENIETTVMSDAAIFAVMSRVNKVIIGTKTILANGALIAVSGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVSPQEVLPFTEGEILAKINVHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDYEL", "length": 351 }, "evidence": [ { "id": "Q5E9B4", "url": "https://omabrowser.org/oma/group/Q5E9B4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B3H7H1-1", "protein_name": "Translation initiation factor eIF2B subunit beta", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MPDVQSTVVEFVNKLRKRKIEGSQATAKYTVELLRSVISHQRVPHANQAAALIDAVKAVGEQLIAANPVELAVGNVVRRVLHIIREEDLSLTTAAMGGLDLLDASDDDDVDNCKGIGFPAMSAAVVAAAARSTLRPPSLQTLLEGTPESATVPYTSSSGADSESKSKSADKSSLTRKLKHDVIEGVNQLIQEIAGCHEQIAEQAIEHIHQNEVILTLGSSRTVLEFLCAAKEKKRSFRVFVAEGAPRYQGHLLAKELVARGLQTTVITDSAVFAMISRVNMVIIGAHAVMANGGVIGPVGVNMAALAAQKHAVPFVVLAGSHKLCPLYPHNPEVLLNELRSPSELLDFGEFSDCLDFGAGSGSLQVVNPTFDYVPPNLVSLFITDTGGHNPSYMYRLIADYYSADDLVM", "length": 409 }, "evidence": [ { "id": "Q5E9B4", "url": "https://omabrowser.org/oma/group/Q5E9B4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "O76863-1", "protein_name": "Translation initiation factor eIF2B subunit beta", "gene_name": "eIF2Bbeta", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MKEQPLKEITQLIHAIKVGLVEGSYNITNKTLDIFKYIIMSKSWQNADALMQIVRDQCKILQAALPQETVTSNIARRILKLTREEFDLLHAKVQHFADDSQASLSLHKLVTQTSESNVSVDYSVPQHGLREALLDHLQEVETELETSSENICVQAEEHIHSSEIILTLGHSRSVENFLKRAIKKRQFLTIIVAECAPACRGHNLAASLANEKNVEIVVIPDAAIFAMMSRVNKVIIGTHSVLANGGLRAACGAYTVALAAKHYSVPVIVLAPMYKLSPLHLCEQDAFNMVGCAEDVIPYDSIPAREAKVYSPMFDYVPPELVTLFISNTGGHAPSYVYRLLTELYHPEDLEI", "length": 352 }, "evidence": [ { "id": "Q5E9B4", "url": "https://omabrowser.org/oma/group/Q5E9B4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P32502-1", "protein_name": "Translation initiation factor eIF2B subunit beta", "gene_name": "GCD7", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSSQAFTSVHPNAATSDVNVTIDTFVAKLKRRQVQGSYAIALETLQLLMRFISAARWNHVNDLIEQIRDLGNSLEKAHPTAFSCGNVIRRILAVLRDEVEEDTMSTTVTSTSVAEPLISSMFNLLQKPEQPHQNRKNSSGSSSMKTKTDYRQVAIQGIKDLIDEIKNIDEGIQQIAIDLIHDHEILLTPTPDSKTVLKFLITARERSNRTFTVLVTEGFPNNTKNAHEFAKKLAQHNIETLVVPDSAVFALMSRVGKVIIGTKAVFVNGGTISSNSGVSSVCECAREFRTPVFAVAGLYKLSPLYPFDVEKFVEFGGSQRILPRMDPRKRLDTVNQITDYVPPENIDIYITNVGGFNPSFIYRIAWDNYKQIDVHLDKNKA", "length": 381 }, "evidence": [ { "id": "Q5E9B4", "url": "https://omabrowser.org/oma/group/Q5E9B4/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P49770-1", "protein_name": "Translation initiation factor eIF2B subunit beta", "gene_name": "EIF2B2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPGSAAKGSELSERIESFVETLKRGGGPRSSEEMARETLGLLRQIITDHRWSNAGELMELIRREGRRMTAAQPSETTVGNMVRRVLKIIREEYGRLHGRSDESDQQESLHKLLTSGGLNEDFSFHYAQLQSNIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKEAARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAVTGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL", "length": 351 }, "evidence": [ { "id": "Q5E9B4", "url": "https://omabrowser.org/oma/group/Q5E9B4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54EY2-1", "protein_name": "Translation initiation factor eIF2B subunit beta", "gene_name": "eif2b2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEKQAEKQLEKQLESFILHLKRKTVVGSYQVSRASAELLRQWVHKGKWGNAKSLIDQIKIIGKKLMNAQPLEFCIGNIVRRVLFIIREEYLTFFRNKKNGLNNDDYDDDDFETTTSNNNNNNNNNNINSSSNINKNNKYSNVMLQDDPIDDQEDIDFTETFPRLKAAIMDSINELIDELEGLHRNVAEQAIEHIHSNETIMTLGCSRTVEEFLKEAARKRSFKVIVVETAPSLEGQKTAISLSKASIDTTLITDSAVFAMMSRVNKVIIGTHAVMANGGLIATSGTHTLAVAAKYHSVPIVVCTGLYKLCPLYAYDQDTFNNFGSPGEYLKFEEAEFLENVHSYNPTFDYVAPDLVSLFITNIGGHNPSYIYRLLQEYYDARDILEDE", "length": 388 }, "evidence": [ { "id": "Q5E9B4", "url": "https://omabrowser.org/oma/group/Q5E9B4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q62818-1", "protein_name": "Translation initiation factor eIF2B subunit beta", "gene_name": "Eif2b2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPGAAAKGSELSERIESFVETLKRGGGRRTSEDMARETLGLLRRLITDHHWNNAGDLMDLIRREGRRMTAAHPPETTVGNMVRRVLKIIREEYGRLHGRSDESDQQESLHKLLTSGGLSEDFSFHYAPLKSNIIEAINELLVELEGTTENIAAQALEHIHSNEVIMTIGFSRTVEAFLREAAQKRKFHVIAAECAPFCQGHEMAVNLSEAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGSLRAVAGTHTLALAAKHHSTPLIVCAPMFKLSPQFPSEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFDYVPPDLITLFISNIGGNAPSYVYRLMSELYHPDDHVL", "length": 351 }, "evidence": [ { "id": "Q5E9B4", "url": "https://omabrowser.org/oma/group/Q5E9B4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99LD9-1", "protein_name": "Translation initiation factor eIF2B subunit beta", "gene_name": "Eif2b2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPGAAAKGSELSERIEGFVETLKRGGGQRSSEDMARETLGLLRRLITDHHWNNAGDLMDLIRREGRRMTAAQPSETTVGNMVRRVLKIIREEYGRLHGRSDESDQQESLHKLLTSGGLSEDFSFHFAPLKANIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGYSRTVEAFLKEAARKRKFHVIVAECAPFCQGHEMAVNLSKEGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGSLRAVAGTHTLALAAKHHSTPLIVCAPMFKLSPQFPSEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFDYVPPDLITLFISNIGGNAPSYIYRLMSELYHPDDHVL", "length": 351 }, "evidence": [ { "id": "Q5E9B4", "url": "https://omabrowser.org/oma/group/Q5E9B4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "cytoplasmic translational initiation", "id": "GO:0002183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002183", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B4", "url": "https://www.uniprot.org/uniprotkb/Q5E9B4" } ], "pmid": "" }, { "name": "myelination", "id": "GO:0042552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042552", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B4", "url": "https://www.uniprot.org/uniprotkb/Q5E9B4" } ], "pmid": "" }, { "name": "T cell receptor signaling pathway", "id": "GO:0050852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B4", "url": "https://www.uniprot.org/uniprotkb/Q5E9B4" } ], "pmid": "" }, { "name": "central nervous system development", "id": "GO:0007417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007417", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B4", "url": "https://www.uniprot.org/uniprotkb/Q5E9B4" } ], "pmid": "" }, { "name": "translational initiation", "id": "GO:0006413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006413", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B4", "url": "https://www.uniprot.org/uniprotkb/Q5E9B4" } ], "pmid": "" }, { "name": "ovarian follicle development", "id": "GO:0001541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001541", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B4", "url": "https://www.uniprot.org/uniprotkb/Q5E9B4" } ], "pmid": "" }, { "name": "oligodendrocyte development", "id": "GO:0014003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014003", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B4", "url": "https://www.uniprot.org/uniprotkb/Q5E9B4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B4", "url": "https://www.uniprot.org/uniprotkb/Q5E9B4" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B4", "url": "https://www.uniprot.org/uniprotkb/Q5E9B4" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B4", "url": "https://www.uniprot.org/uniprotkb/Q5E9B4" } ], "pmid": "" }, { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B4", "url": "https://www.uniprot.org/uniprotkb/Q5E9B4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B4", "url": "https://www.uniprot.org/uniprotkb/Q5E9B4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B4", "url": "https://www.uniprot.org/uniprotkb/Q5E9B4" } ], "pmid": "" }, { "name": "eukaryotic translation initiation factor 2B complex", "id": "GO:0005851", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005851", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B4", "url": "https://www.uniprot.org/uniprotkb/Q5E9B4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9B4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 351, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9B4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9B4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBR7-1", "uniprot_ac": "Q3ZBR7", "uniprot_id": "RM18_BOVIN", "mass": { "chemical_mass": 20397.0, "monoisotopic_mass": 20397.0 }, "refseq": { "ac": "NP_001029780", "name": "large ribosomal subunit protein uL18m", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029780" }, "gene_names": [ { "name": "MRPL18", "type": "recommended", "evidence": [ { "id": "Q3ZBR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7" } ] }, { "name": "MRPL18", "type": "synonym", "evidence": [ { "id": "NP_001029780", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029780" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein uL18m", "type": "recommended", "evidence": [ { "id": "Q3ZBR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7/entry#names_and_taxonomy" } ] }, { "name": "39S ribosomal protein L18, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001029780", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029780" }, { "id": "Q3ZBR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7/entry#names_and_taxonomy" } ] }, { "name": "L18mt", "type": "synonym", "evidence": [ { "id": "NP_001029780", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029780" }, { "id": "Q3ZBR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7/entry#names_and_taxonomy" } ] }, { "name": "MRP-L18", "type": "synonym", "evidence": [ { "id": "NP_001029780", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029780" }, { "id": "Q3ZBR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein uL18m", "type": "synonym", "evidence": [ { "id": "NP_001029780", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029780" } ] } ], "function": [ { "annotation": "Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7#function" }, { "database": "UniProtKB", "id": "Q9H0U6", "url": "https://www.uniprot.org/uniprotkb/Q9H0U6#function" }, { "database": "UniProtKB", "id": "A0AAA9SSM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSM2#function" }, { "database": "UniProtKB", "id": "ARBA00059887", "url": "https://www.uniprot.org/uniprotkb/ARBA00059887#function" }, { "database": "UniProtKB", "id": "A0AAA9SYQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYQ3#function" }, { "database": "UniProtKB", "id": "A0AAF6YI06", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI06#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRPL18", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7", "locus": { "chromosome": "9", "start_pos": 96061780, "end_pos": 96055635, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001289", "url": "https://www.ensembl.org/id/ENSBTAG00000001289" } ] } } ], "crossref": [ { "id": "Q3ZBR7", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBR7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001289", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001289", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00432", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00432", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534352", "url": "https://www.ncbi.nlm.nih.gov/gene/534352", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005484", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005484", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057268", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057268", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534352", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534352", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TSEWAIK", "url": "https://omabrowser.org/oma/group/TSEWAIK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBR7", "url": "https://www.orthodb.org/?gene=Q3ZBR7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12899", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12899", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12899:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12899:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00861", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00861", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9937383", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029780", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SSM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSM2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSM2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YI06", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YI06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI06-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBR7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBR7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALRSRSWELLPVCRNPGCRVAAFSTSAKPVVKPEADPVGNEAVAPEFTNRNPRNLELLAVARKERGWGTVWPSREFWHRLRVIRSQHHIEALVEHRNGQVVVSASTREWAIKKHLYSTKSVVACESVGRVLAQRCLEAGINFMVYQPTPWEAASDSMKRLQIGMIEGGVVLQEPRRIYE", "length": 180, "header": "sp|Q3ZBR7-1|RM18_BOVIN Isoform 1 of Large ribosomal subunit protein uL18m OS=Bos taurus OX=9913 GN=MRPL18 PE=2 SV=1 CANONICAL=Q3ZBR7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSM2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7/entry#A0AAA9SSM2-1", "sequence": { "sequence": "RGDLGLYDLTSFEGFSLRCRVAAFSTSAKPVVKPEADPVGNEAVAPEFTNRNPRNLELLAVARKERGWGTVWPSREFWHRLRVIRSQHHIEALVEHRNGQVVVSASTREWAIKKHLYSTKSVVACESVGRVLAQRCLEAGINFMVYQPTPWEAASDSMKRLQIGMIEGGVVLQEPRRIYE", "length": 180, "header": "tr|A0AAA9SSM2-1|RM18_BOVIN Computationally mapped isoform of Large ribosomal subunit protein uL18m OS=Bos taurus OX=9913 GN=MRPL18 PE=2 SV=1 CANONICAL=Q3ZBR7-1" }, "locus": { "chromosome": "9", "start_pos": 96061476, "end_pos": 96056467, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102066.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102066.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086994.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086994.1" } ] } }, { "isoform_ac": "A0AAA9SYQ3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7/entry#A0AAA9SYQ3-1", "sequence": { "sequence": "ESGSQYLGPLKGGGCRVAAFSTSAKPVVKPEADPVGNEAVAPEFTNRNPRNLELLAVARKERGWGTVWPSREFWHRLRVIRSQHHIEALVEHRNGQVVVSASTREWAIKKHLYSTKSVVACESVGRVLAQRCLEAGINFMVYQPTPWEAASDSMKRLQIGMIEGGVVLQEPRRIYE", "length": 176, "header": "tr|A0AAA9SYQ3-1|RM18_BOVIN Computationally mapped isoform of Large ribosomal subunit protein uL18m OS=Bos taurus OX=9913 GN=MRPL18 PE=2 SV=2 CANONICAL=Q3ZBR7-1" }, "locus": { "chromosome": "9", "start_pos": 96061476, "end_pos": 96055766, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113349.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113349.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091586.2", "url": "https://www.ensembl.org/id/ENSBTAP00000091586.2" } ] } }, { "isoform_ac": "A0AAF6YI06-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7/entry#A0AAF6YI06-1", "sequence": { "sequence": "DPCGGFCSLGCRVAAFSTSAKPVVKPEADPVGNEAVAPEFTNRNPRNLELLAVARKERGWGTVWPSREFWHRLRVIRSQHHIEALVEHRNGQVVVSASTREWAIKKHLYSTKSVVACESVGRVLAQRCLEAGINFMVYQPTPWEAASDSMKRLQIGMIEGGVVLQEPRRIYE", "length": 172, "header": "tr|A0AAF6YI06-1|RM18_BOVIN Computationally mapped isoform of Large ribosomal subunit protein uL18m OS=Bos taurus OX=9913 GN=MRPL18 PE=2 SV=1 CANONICAL=Q3ZBR7-1" }, "locus": { "chromosome": "9", "start_pos": 96061477, "end_pos": 96056612, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001699.4", "url": "https://www.ensembl.org/id/ENSBTAT00000001699.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001699.3", "url": "https://www.ensembl.org/id/ENSBTAP00000001699.3" } ] } }, { "isoform_ac": "Q3ZBR7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7/entry#Q3ZBR7-1", "sequence": { "sequence": "MALRSRSWELLPVCRNPGCRVAAFSTSAKPVVKPEADPVGNEAVAPEFTNRNPRNLELLAVARKERGWGTVWPSREFWHRLRVIRSQHHIEALVEHRNGQVVVSASTREWAIKKHLYSTKSVVACESVGRVLAQRCLEAGINFMVYQPTPWEAASDSMKRLQIGMIEGGVVLQEPRRIYE", "length": 180, "header": "sp|Q3ZBR7-1|RM18_BOVIN Isoform 1 of Large ribosomal subunit protein uL18m OS=Bos taurus OX=9913 GN=MRPL18 PE=2 SV=1 CANONICAL=Q3ZBR7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534352", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534352", "resource": "KEGG Pathway" }, { "id": "R-BTA-5389840", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-9937383", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "resource": "Reactome", "description": "Mitochondrial ribosome-associated quality control" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4J8D5-1", "protein_name": "Large ribosomal subunit protein uL18m", "gene_name": "MRPL18", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALRSRFWALLSICRNPGCRAAALSTSCKPATNPETDPVENEAVAPEFTNRNPRNLELLAVARKERGWGTVWPSREFWHRLRVIRTQHHIEALVEHRNGQVVVSASTREWAIKKHLYSTRNVVACESVGRVLAERCLEAGINFMVYHPTPWEAASDSIKRLQHAMTEGGVVLREPRRIYE", "length": 180 }, "evidence": [ { "id": "Q3ZBR7", "url": "https://omabrowser.org/oma/group/Q3ZBR7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9CQL5-1", "protein_name": "Large ribosomal subunit protein uL18m", "gene_name": "Mrpl18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALRPRFWKCLSVCRKLECGFAALSTSSVPAVQPDVESKENEAVAPEFTNRNPRNLELLGVARKERGWATVWPNREFWHRLRVVKTQHHVEAFVEHLNGQVVVSASTREWAIKKHLYSTRNVVACESIGRVLAQRCLEAGINFMVYQPTPWEASSDSIKRLQNAMTESGVMLREPRRIYE", "length": 180 }, "evidence": [ { "id": "Q3ZBR7", "url": "https://omabrowser.org/oma/group/Q3ZBR7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H0U6-1", "protein_name": "Large ribosomal subunit protein uL18m", "gene_name": "MRPL18", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALRSRFWGLFSVCRNPGCRFAALSTSSEPAAKPEVDPVENEAVAPEFTNRNPRNLELLSVARKERGWRTVFPSREFWHRLRVIRTQHHVEALVEHQNGKVVVSASTREWAIKKHLYSTRNVVACESIGRVLAQRCLEAGINFMVYQPTPWEAASDSMKRLQSAMTEGGVVLREPQRIYE", "length": 180 }, "evidence": [ { "id": "Q3ZBR7", "url": "https://omabrowser.org/oma/group/Q3ZBR7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7" } ], "pmid": "" }, { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7" } ], "pmid": "" }, { "name": "rRNA import into mitochondrion", "id": "GO:0035928", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035928", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "5S rRNA binding", "id": "GO:0008097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008097", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBR7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 180, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBR7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBR7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q58DT5-1", "uniprot_ac": "Q58DT5", "uniprot_id": "ELMD3_BOVIN", "mass": { "chemical_mass": 42632.0, "monoisotopic_mass": 42632.0 }, "refseq": {}, "gene_names": [ { "name": "ELMOD3", "type": "recommended", "evidence": [ { "id": "Q58DT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DT5" } ] }, { "name": "RBED1", "type": "synonym", "evidence": [ { "id": "Q58DT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DT5" } ] } ], "protein_names": [ { "name": "ELMO domain-containing protein 3", "type": "recommended", "evidence": [ { "id": "Q58DT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DT5/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding motif and ELMO domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "Q58DT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DT5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity.", "evidence": [ { "database": "UniProtKB", "id": "Q58DT5", "url": "https://www.uniprot.org/uniprotkb/Q58DT5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DT5", "url": "https://www.uniprot.org/uniprotkb/Q58DT5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ELMOD3", "url": "https://www.uniprot.org/uniprotkb/Q58DT5", "locus": { "chromosome": "11", "start_pos": 49608573, "end_pos": 49642020, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021935", "url": "https://www.ensembl.org/id/ENSBTAG00000021935" } ] } } ], "crossref": [ { "id": "Q58DT5", "url": "https://alphafold.ebi.ac.uk/entry/Q58DT5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021935", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021935", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "535421", "url": "https://www.ncbi.nlm.nih.gov/gene/535421", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006816", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006816", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050868", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050868", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PHWENIG", "url": "https://omabrowser.org/oma/group/PHWENIG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MFA6", "url": "https://www.orthodb.org/?gene=F1MFA6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q58DT5", "url": "https://www.orthodb.org/?gene=Q58DT5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12771", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12771", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12771:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12771:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04727", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04727", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T0H1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0H1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0H1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T267", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T267", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T267-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T267-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLG0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLG0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZJF4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZJF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJF4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFA6", "url": "https://www.uniprot.org/uniprotkb/F1MFA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFA6-1", "url": "https://www.uniprot.org/uniprotkb/F1MFA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DT5", "url": "https://www.uniprot.org/uniprotkb/Q58DT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DT5-1", "url": "https://www.uniprot.org/uniprotkb/Q58DT5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DT5-2", "url": "https://www.uniprot.org/uniprotkb/Q58DT5-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DT5-3", "url": "https://www.uniprot.org/uniprotkb/Q58DT5-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNENFHSFHEKELRDGQVESVSAGSSPPCDKDSSALLAFRGISISELKNHSVLQALTAEANAWEPRVVSTEVLQAQEEWEAVESIHPETGSRASMDQPGQLISFSEALQHFQTVDLSSFKKRIQPTIRRTGLAALRHYLFGPPKLHQGLREERDLVLTIAQCGLDSQDPMHGRVLQTIYKKLTGSKFDCALHGDHWEDLGFQGTNPATDLRGAGFLALLHLLYLVMDSKTLLMAREILRLSRHHIQQFPFCLMSVNITRIAIQALREECLSRECNRQQKVIPVVNSFYAATFLRLAHIWRTQHKTISDSGFVLKDLEMSAKKSPRRLLKTLETYLAGVSKGQASLLGTQKCSGPQAPHSKDLTFTGVCDLPSHLSEGTWLI", "length": 381, "header": "sp|Q58DT5-1|ELMD3_BOVIN Isoform 1 of ELMO domain-containing protein 3 OS=Bos taurus OX=9913 GN=ELMOD3 PE=2 SV=1 CANONICAL=Q58DT5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T0H1-1", "url": "https://www.uniprot.org/uniprotkb/Q58DT5/entry#A0AAA9T0H1-1", "sequence": { "sequence": "MQEWVKSLGREDPLEEETATHSSILAWKIPWTEEPGRLQSVGSQRVDTTERLSMHSLRLALTNPSGKTDSNGLQFQEYLISELKNHSVLQALTAEANAWEPRVVSTEVLQAQEEWEAVESIHPETGSRASMDQPGQLISFSEALQHFQTVDLSSFKKRIQPTIRRTGLAALRHYLFGPPKLHQGLREERDLVLTIAQCGLDSQDPMHGRVLQTIYKKLTGSKFDCALHGDHWEDLGFQGTNPATDLRGAGFLALLHLLYLVMDSKTLLMAREILRLSRHHIQQFPFCLMSVNITRIAIQALREECLSRECNRQQKVIPVVNSFYAATFLRLAHVWRTQHKTISDSGFVLKDLEMSAKKSPRRLLKTLETYLAGVSKGQGSLLGTQKCSGPQAPHSKDLTFTGVCDLPSHLSEGTWLI", "length": 417, "header": "tr|A0AAA9T0H1-1|ELMD3_BOVIN Computationally mapped isoform of ELMO domain-containing protein 3 OS=Bos taurus OX=9913 GN=ELMOD3 PE=2 SV=1 CANONICAL=Q58DT5-1" }, "locus": { "chromosome": "11", "start_pos": 49634317, "end_pos": 49609264, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100973.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100973.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090012.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090012.1" } ] } }, { "isoform_ac": "A0AAA9T267-1", "url": "https://www.uniprot.org/uniprotkb/Q58DT5/entry#A0AAA9T267-1", "sequence": { "sequence": "MASSFKNIWYSGQYVFVWIGGLGLRPHTEGHLPLQISELKNHSVLQALTAEANAWEPRGSRASMDQPGQLISFSEALQHFQTVDLSSFKKRIQPTIRRTGLAALRHYLFGPPKLHQGLREERDLVLTIAQCGLDSQDPMHGRVLQTIYKKLTGSKFDCALHGDHWEDLGFQGTNPATDLRGAGFLALLHLLYLVMDSKTLLMAREILRLSRHHIQQFPFCLMSVNITRIAIQALREECLSRECNRQQKVIPVVNSFYAATFLRLAHVWRTQHKTISDSGFVLKDLEMSAKKSPRRLLKTLETYLAGVSKGQGSLLGTQKCSGPQAPHSKDLTFTGVCDLPSHLSEGTWLI", "length": 350, "header": "tr|A0AAA9T267-1|ELMD3_BOVIN Computationally mapped isoform of ELMO domain-containing protein 3 OS=Bos taurus OX=9913 GN=ELMOD3 PE=2 SV=1 CANONICAL=Q58DT5-1" }, "locus": { "chromosome": "11", "start_pos": 49634106, "end_pos": 49609264, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103748.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103748.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090498.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090498.1" } ] } }, { "isoform_ac": "A0AAF6DLG0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DT5/entry#A0AAF6DLG0-1", "sequence": { "sequence": "MVLPRFLIFDNKVESVSAGSSPPCDKDSSALLAFRGISISELKNHSVLQALTAEANAWEPRVVSTEVLQAQEEWEAVESIHPETGSRASMDQPGQLISFSEALQHFQTVDLSSFKKRIQPTIRRTGLAALRHYLFGPPKLHQGLREERDLVLTIAQCGLDSQDPMHGRVLQTIYKKLTGSKFDCALHGDHWEDLGFQGTNPATDLRGAGFLALLHLLYLVMDSKTLLMAREILRLSRHHIQQFPFCLMSVNITRIAIQALREECLSRECNRQQKVIPVVNSFYAATFLRLAHVWRTQHKTISDSGFVLKDLEMSAKKSPRRLLKTLETYLAGVSKGQGSLLGTQKCSGPQAPHSKDLTFTGVCDLPSHLSEGTWLI", "length": 376, "header": "tr|A0AAF6DLG0-1|ELMD3_BOVIN Computationally mapped isoform of ELMO domain-containing protein 3 OS=Bos taurus OX=9913 GN=ELMOD3 PE=2 SV=1 CANONICAL=Q58DT5-1" }, "locus": { "chromosome": "11", "start_pos": 49635596, "end_pos": 49609264, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033050.5", "url": "https://www.ensembl.org/id/ENSBTAT00000033050.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032975.5", "url": "https://www.ensembl.org/id/ENSBTAP00000032975.5" } ] } }, { "isoform_ac": "A0AAF6ZJF4-1", "url": "https://www.uniprot.org/uniprotkb/Q58DT5/entry#A0AAF6ZJF4-1", "sequence": { "sequence": "MRLQAPNRHSIHDRVRYYQVESVSAGSSPPCDKDSSALLAFRGISISELKNHSVLQALTAEANAWEPRVVSTEVLQAQEEWEAVESIHPETGSRASMDQPGQLISFSEALQHFQTVDLSSFKKRIQPTIRRTGLAALRHYLFGPPKLHQGLREERDLVLTIAQCGLDSQDPMHGRVLQTIYKKLTGSKFDCALHGDHWEDLGFQGTNPATDLRGAGFLALLHLLYLVMDSKTLLMAREILRLSRHHIQQFPFCLMSVNITRIAIQALREECLSRECNRQQKVIPVVNSFYAATFLRLAHVWRTQHKTISDSGFVLKDLEMSAKKSPRRLLKTLETYLAGVSKGQGSLLGTQKCSGPQAPHSKDLTFTGVCDLPSHLSEGTWLI", "length": 383, "header": "tr|A0AAF6ZJF4-1|ELMD3_BOVIN Computationally mapped isoform of ELMO domain-containing protein 3 OS=Bos taurus OX=9913 GN=ELMOD3 PE=2 SV=1 CANONICAL=Q58DT5-1" }, "locus": { "chromosome": "11", "start_pos": 49635713, "end_pos": 49609264, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054220.4", "url": "https://www.ensembl.org/id/ENSBTAT00000054220.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049817.3", "url": "https://www.ensembl.org/id/ENSBTAP00000049817.3" } ] } }, { "isoform_ac": "F1MFA6-1", "url": "https://www.uniprot.org/uniprotkb/Q58DT5/entry#F1MFA6-1", "sequence": { "sequence": "MNENSHSFHEKELRDGQVESVSAGSSPPCDKDSSALLAFRGISISELKNHSVLQALTAEANAWEPRVVSTEVLQAQEEWEAVESIHPETGSRASMDQPGQLISFSEALQHFQTVDLSSFKKRIQPTIRRTGLAALRHYLFGPPKLHQGLREERDLVLTIAQCGLDSQDPMHGRVLQTIYKKLTGSKFDCALHGDHWEDLGFQGTNPATDLRGAGFLALLHLLYLVMDSKTLLMAREILRLSRHHIQQFPFCLMSVNITRIAIQALREECLSRECNRQQKVIPVVNSFYAATFLRLAHVWRTQHKTISDSGFVLKDLEMSAKKSPRRLLKTLETYLAGVSKGQGSLLGTQKCSGPQAPHSKDLTFTGVCDLPSHLSEGTWLI", "length": 381, "header": "tr|F1MFA6-1|ELMD3_BOVIN Computationally mapped isoform of ELMO domain-containing protein 3 OS=Bos taurus OX=9913 GN=ELMOD3 PE=2 SV=3 CANONICAL=Q58DT5-1" }, "locus": { "chromosome": "11", "start_pos": 49638447, "end_pos": 49609264, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029243.7", "url": "https://www.ensembl.org/id/ENSBTAT00000029243.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029243.6", "url": "https://www.ensembl.org/id/ENSBTAP00000029243.6" } ] } }, { "isoform_ac": "Q58DT5-1", "url": "https://www.uniprot.org/uniprotkb/Q58DT5/entry#Q58DT5-1", "sequence": { "sequence": "MNENFHSFHEKELRDGQVESVSAGSSPPCDKDSSALLAFRGISISELKNHSVLQALTAEANAWEPRVVSTEVLQAQEEWEAVESIHPETGSRASMDQPGQLISFSEALQHFQTVDLSSFKKRIQPTIRRTGLAALRHYLFGPPKLHQGLREERDLVLTIAQCGLDSQDPMHGRVLQTIYKKLTGSKFDCALHGDHWEDLGFQGTNPATDLRGAGFLALLHLLYLVMDSKTLLMAREILRLSRHHIQQFPFCLMSVNITRIAIQALREECLSRECNRQQKVIPVVNSFYAATFLRLAHIWRTQHKTISDSGFVLKDLEMSAKKSPRRLLKTLETYLAGVSKGQASLLGTQKCSGPQAPHSKDLTFTGVCDLPSHLSEGTWLI", "length": 381, "header": "sp|Q58DT5-1|ELMD3_BOVIN Isoform 1 of ELMO domain-containing protein 3 OS=Bos taurus OX=9913 GN=ELMOD3 PE=2 SV=1 CANONICAL=Q58DT5-1" }, "locus": {} }, { "isoform_ac": "Q58DT5-2", "url": "https://www.uniprot.org/uniprotkb/Q58DT5/entry#Q58DT5-2", "sequence": { "sequence": "MNENFHSFHEKELRDGQVESVSAGSSPPCDKDSSALLAFRGISISELKNHSVLQALTAEANAWEPRVVSTEVLQAQEEWEAVESIHPETGSRASMDQPGQLISFSEALQHFQTVDLSSFKKRIQPTIRRTGLAALRHYLFGPPKLHQGLREERDLVLTIAQCGLDSQDPMHGRVLQTIYKKLTGSKFDCALHGDHWEDLGFQGTNPATDLRGAGFLALLHLLYLVMDSKTLLMAREILRLSRHHIQP", "length": 247, "header": "sp|Q58DT5-2|ELMD3_BOVIN Isoform 2 of ELMO domain-containing protein 3 OS=Bos taurus OX=9913 GN=ELMOD3 PE=2 SV=1 CANONICAL=Q58DT5-1" }, "locus": {} }, { "isoform_ac": "Q58DT5-3", "url": "https://www.uniprot.org/uniprotkb/Q58DT5/entry#Q58DT5-3", "sequence": { "sequence": "MVLPRFLIFDNKVESVSAGSSPPCDKDSSALLAFRGISISELKNHSVLQALTAEANAWEPRVVSTEVLQAQEEWEAVESIHPETGSRASMDQPGQLISFSEALQHFQTVDLSSFKKRIQPTIRRTGLAALRHYLFGPPKLHQGLREERDLVLTIAQCGLDSQDPMHGRVLQTIYKKLTGSKFDCALHGDHWEDLGFQGTNPATDLRGAGFLALLHLLYLVMDSKTLLMAREILRLSRHHIQP", "length": 242, "header": "sp|Q58DT5-3|ELMD3_BOVIN Isoform 3 of ELMO domain-containing protein 3 OS=Bos taurus OX=9913 GN=ELMOD3 PE=2 SV=1 CANONICAL=Q58DT5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DT5", "url": "https://www.uniprot.org/uniprotkb/Q58DT5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8D0LNQ7-1", "protein_name": "ELMO domain containing 3", "gene_name": "ELMOD3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSENSCSFRNEKERRDGQVEGVSAGYSPPCDKDNSALLAFRGIPISELKNHSILRALTVEANGWQPGVVNTEVLRAQEEWEAVDSIHPETGSQASSEQPGHLVSFSEALQHFQTVDLSSFKKRIQPTIRRTGLAALRHCLFGPPKLHQDLREERDLVLTIAQCGLDSQDPMHGRVLQTIYKKLTGSKFDCALHGDHWEDLGFQGANPATDLRGAGFLALLHLLYLVMDSKTLLMAQEIFRLSRHHIQQFPFCVMSVNITRITIQALREECLSRECNRQQKVIPVVNSFYAATFLRLAHIWRTQHKTISDSGFVLKDLEAWAKKSPRRLLKTLEIYLAGVSKGQASLLGAQKCSRPRAPHSKDLTFTGVCDLPPNSPQATWLI", "length": 382 }, "evidence": [ { "id": "Q58DT5", "url": "https://omabrowser.org/oma/group/Q58DT5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7H484-1", "protein_name": "ELMO domain-containing protein 3 isoform X1", "gene_name": "Elmod3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRNLALLGLRTKYEMDRLPAASVGQISGGFSYFRSSSQEKSLTGGKCLCRTFFIVQGQQYTHGFQRNAFVNSEVLRAQEEWDVVDTIHPDPEIGVSSQQPGQLISFSEALQHFQTLDLSSFKKRIQPTIRRTGLAALRHCLFGPPKLHQGLREERDLVLTIAQCGLDSQDPMHGRVLQTIYKKLTGSKFDCALHGDHWEDLGFQGANPATDLRGAGFLALLHLLYLVMDSKTLLMAQEIFRLSHHHIQQFPFCLMSVNITRIAIQALREECLSRECNRRQKVIPVVNSFYAAAFLHLARVWRTQQKTISDSGFVLKDLEVLAKKSPKRLLKTLEVYLARVSKGQASLLETQKCSGSEGSHSKDLTFTGVCDLQSHSFESTGLI", "length": 383 }, "evidence": [ { "id": "Q58DT5", "url": "https://omabrowser.org/oma/group/Q58DT5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5XIQ2-1", "protein_name": "ELMO domain-containing protein 3", "gene_name": "Elmod3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSETSCSFLIEKEFQDGQVESVSAGLSPSYKDNGALMAFRGIPISELKNHGILQVLTAETNGWQPGVVSAEMLRAQEEWEVVDTIHPDIESGVSSQQPGQFISFNEALEHFQTVDLSSFKKRIQPTIQRTGLAALRHCLFGPPKLHQGLQEERDLVLTIAQCGLDSQNPTHGRVLQTIYKKLTGSKFDCALHGDHWEDLGFQGANPATDLRGTGFLALLHLLYLVMDSKTLLMAQEILRLSHHHIQQFPFCLMSVNITRIAIQALREECLSRECNRRRKVIPVVNSFYAATFLHLARMWRTQHNTILDSGFVLKELGIEPRALRSIGKRSTAELNPQPAPAFLVWDYSRAFMHGSR", "length": 356 }, "evidence": [ { "id": "Q58DT5", "url": "https://omabrowser.org/oma/group/Q58DT5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91YP6-1", "protein_name": "ELMO domain-containing protein 3", "gene_name": "Elmod3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSETSCSFFIEKEFQDGQLENVSAGLSSSYKDKGALMAFRGIPISELTNHGILQALTAETNGWQPGVVSEEVLRAQEEWEVVDTIHPDIESGVHCQQPGQLISFNEALEHFQSVDLSSFKKRIQPTIQRTGLAALRHCLFGPPKLHQGLREERDLVLTIAQCGLDSQNPTHGRVLQTIYKKLTGSKFDCALHGDHWEDLGFQGANPATDLRGAGFLALLHLLYLVMDSKTFLMAQEIFRLSHHHIQQFPFCLMSVNITRIAIQALREECLSRECNRRQKVIPVVNSFYAATFLHLARVWRTQQKTILDSGFVLKDLEALAKKSPKRLLKTLDDYLAQVSKGQTSLLEAHKRPGSQGPHSRDLTFTGVCDLQSHSFESAGLI", "length": 381 }, "evidence": [ { "id": "Q58DT5", "url": "https://omabrowser.org/oma/group/Q58DT5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96FG2-1", "protein_name": "ELMO domain-containing protein 3", "gene_name": "ELMOD3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNEKSCSFHSKEELRDGQGERLSAGYSPSYDKDKSVLAFRGIPISELKNHGILQALTTEAYEWEPRVVSTEVVRAQEEWEAVDTIQPETGSQASSEQPGQLISFSEALQHFQTVDLSPFKKRIQPTIRRTGLAALRHYLFGPPKLHQRLREERDLVLTIAQCGLDSQDPVHGRVLQTIYKKLTGSKFDCALHGNHWEDLGFQGANPATDLRGAGFLALLHLLYLVMDSKTLPMAQEIFRLSRHHIQQFPFCLMSVNITHIAIQALREECLSRECNRQQKVIPVVNSFYAATFLHLAHVWRTQRKTISDSGFVLKELEVLAKKSPRRLLKTLELYLARVSKGQASLLGAQKCYGPEAPPFKDLTFTGESDLQSHSSEGVWLI", "length": 381 }, "evidence": [ { "id": "Q58DT5", "url": "https://omabrowser.org/oma/group/Q58DT5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q58DT5", "url": "https://www.uniprot.org/uniprotkb/Q58DT5" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q58DT5", "url": "https://www.uniprot.org/uniprotkb/Q58DT5" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "Q58DT5", "url": "https://www.uniprot.org/uniprotkb/Q58DT5" } ], "pmid": "" }, { "name": "kinocilium", "id": "GO:0060091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060091", "evidence": [ { "database": "UniProtKB", "id": "Q58DT5", "url": "https://www.uniprot.org/uniprotkb/Q58DT5" } ], "pmid": "" }, { "name": "stereocilium", "id": "GO:0032420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032420", "evidence": [ { "database": "UniProtKB", "id": "Q58DT5", "url": "https://www.uniprot.org/uniprotkb/Q58DT5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "Q58DT5", "url": "https://www.uniprot.org/uniprotkb/Q58DT5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" }, { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DT5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 381, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DT5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DT5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58DT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DT5" }, { "id": "PRU00664", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00664" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ELMO", "eco_id": "ECO_0000255", "start_pos": 170, "end_pos": 324, "start_aa": "Met", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 256, "end_pos": 258 }, { "start_pos": 49, "end_pos": 51 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58D63-1", "uniprot_ac": "Q58D63", "uniprot_id": "MOB3A_BOVIN", "mass": { "chemical_mass": 25410.0, "monoisotopic_mass": 25410.0 }, "refseq": { "ac": "NP_001029401", "name": "MOB kinase activator 3A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029401" }, "gene_names": [ { "name": "MOB3A", "type": "recommended", "evidence": [ { "id": "Q58D63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D63" } ] }, { "name": "MOB3A", "type": "synonym", "evidence": [ { "id": "NP_001029401", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029401" } ] }, { "name": "MOBKL2A", "type": "synonym", "evidence": [ { "id": "NP_001029401", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029401" }, { "id": "Q58D63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D63" } ] } ], "protein_names": [ { "name": "MOB kinase activator 3A", "type": "recommended", "evidence": [ { "id": "Q58D63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D63/entry#names_and_taxonomy" } ] }, { "name": "MOB kinase activator 3A", "type": "synonym", "evidence": [ { "id": "NP_001029401", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029401" } ] }, { "name": "MOB-LAK", "type": "synonym", "evidence": [ { "id": "NP_001029401", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029401" } ] }, { "name": "MOB1, Mps One Binder kinase activator-like 2A", "type": "synonym", "evidence": [ { "id": "NP_001029401", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029401" } ] }, { "name": "Mob1 homolog 2A", "type": "synonym", "evidence": [ { "id": "Q58D63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D63/entry#names_and_taxonomy" } ] }, { "name": "Mps one binder kinase activator-like 2A", "type": "synonym", "evidence": [ { "id": "Q58D63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D63/entry#names_and_taxonomy" } ] }, { "name": "mob1 homolog 2A", "type": "synonym", "evidence": [ { "id": "NP_001029401", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029401" } ] }, { "name": "mps one binder kinase activator-like 2A", "type": "synonym", "evidence": [ { "id": "NP_001029401", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029401" } ] } ], "function": [ { "annotation": "May regulate the activity of kinases.", "evidence": [ { "database": "UniProtKB", "id": "Q58D63", "url": "https://www.uniprot.org/uniprotkb/Q58D63#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58D63", "url": "https://www.uniprot.org/uniprotkb/Q58D63" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MOB3A", "url": "https://www.uniprot.org/uniprotkb/Q58D63", "locus": { "chromosome": "7", "start_pos": 21469675, "end_pos": 21463053, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000056097", "url": "https://www.ensembl.org/id/ENSBTAG00000056097" } ] } } ], "crossref": [ { "id": "Q58D63", "url": "https://alphafold.ebi.ac.uk/entry/Q58D63", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014526", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014526", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505007", "url": "https://www.ncbi.nlm.nih.gov/gene/505007", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036703", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036703", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505007", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505007", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HMGSEAH", "url": "https://omabrowser.org/oma/group/HMGSEAH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58D63", "url": "https://www.orthodb.org/?gene=Q58D63", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22599", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22599", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03637", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03637", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029401", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T564", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T564", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T564-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T564-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z055", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z055", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z055-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z055-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D63", "url": "https://www.uniprot.org/uniprotkb/Q58D63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D63-1", "url": "https://www.uniprot.org/uniprotkb/Q58D63-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSNPFLKQVFNKDKTFRPKRKFEPGTQRFELHKKAQASLNAGLDLKLAVQLPAGEELNDWVAVHVVDFFNRVNLIYGTISDGCTERSCPIMSGGPKYEYRWQDENKFRRPTALSAPRYMDLLMDWIEVQINNEDVFPTNVGTPFPKNFLQVVKKILSRLFRVFVHVYIHHFDRIAQLGSEAHVNTCYKHFYYFVTEFGLIDTKELEPLKEMTARMCH", "length": 217, "header": "sp|Q58D63-1|MOB3A_BOVIN Isoform 1 of MOB kinase activator 3A OS=Bos taurus OX=9913 GN=MOB3A PE=2 SV=2 CANONICAL=Q58D63-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T564-1", "url": "https://www.uniprot.org/uniprotkb/Q58D63/entry#A0AAA9T564-1", "sequence": { "sequence": "MSNPFLKQVFNKDKTFRPKRKFEPGTQRFELHKKAQASLNAGLDLKLAVQLPAGEELNDWVAVHVVDFFNRVNLIYGTISDGCTERSCPIMSGGPKYEYRWQDENKFRRPTALSAPRYMDLLMDWIEVQINNEDVFPTNVGTPFPKNFLQVVKKILSRLFRVFVHVYIHHFDRIAQLGSEAHVNTCYKHFYYFVTEFGLIDTKELEPLERNDRTDVPLRALGPVISAATPWGPAAATRHISSTGTSVF", "length": 248, "header": "tr|A0AAA9T564-1|MOB3A_BOVIN Computationally mapped isoform of MOB kinase activator 3A OS=Bos taurus OX=9913 GN=MOB3A PE=2 SV=1 CANONICAL=Q58D63-1" }, "locus": { "chromosome": "7", "start_pos": 21469580, "end_pos": 21463083, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087867.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087867.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091678.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091678.1" } ] } }, { "isoform_ac": "A0AAF6Z055-1", "url": "https://www.uniprot.org/uniprotkb/Q58D63/entry#A0AAF6Z055-1", "sequence": { "sequence": "MSNPFLKQVFNKDKTFRPKRKFEPGTQRFELHKKAQASLNAGLDLKLAVQLPAGEELNDWVAVHVVDFFNRVNLIYGTISDGCTERSCPIMSGGPKYEYRWQDENKFRRPTALSAPRYMDLLMDWIEVQINNEDVFPTNVGTPFPKNFLQVVKKILSRLFRVFVHVYIHHFDRIAQLGSEAHVNTCYKHFYYFVTEFGLIDTKELEPLVSMELHLCHILNPTQK", "length": 224, "header": "tr|A0AAF6Z055-1|MOB3A_BOVIN Computationally mapped isoform of MOB kinase activator 3A OS=Bos taurus OX=9913 GN=MOB3A PE=2 SV=1 CANONICAL=Q58D63-1" }, "locus": { "chromosome": "7", "start_pos": 21468685, "end_pos": 21463083, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019309.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019309.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019309.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019309.5" } ] } }, { "isoform_ac": "Q58D63-1", "url": "https://www.uniprot.org/uniprotkb/Q58D63/entry#Q58D63-1", "sequence": { "sequence": "MSNPFLKQVFNKDKTFRPKRKFEPGTQRFELHKKAQASLNAGLDLKLAVQLPAGEELNDWVAVHVVDFFNRVNLIYGTISDGCTERSCPIMSGGPKYEYRWQDENKFRRPTALSAPRYMDLLMDWIEVQINNEDVFPTNVGTPFPKNFLQVVKKILSRLFRVFVHVYIHHFDRIAQLGSEAHVNTCYKHFYYFVTEFGLIDTKELEPLKEMTARMCH", "length": 217, "header": "sp|Q58D63-1|MOB3A_BOVIN Isoform 1 of MOB kinase activator 3A OS=Bos taurus OX=9913 GN=MOB3A PE=2 SV=2 CANONICAL=Q58D63-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58D63", "url": "https://www.uniprot.org/uniprotkb/Q58D63" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:505007", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505007", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PZY9-1", "protein_name": "MOB kinase activator 3A", "gene_name": "MOB3A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSHALKQVFNKDKTFRPKRKFEPGTQRFELHKKAQASLNAGLDLKVAVQLPPGEEQNDWVAVHVVDFFNRINLIYGTISDYCTEQSCPVMSGGPRYEYRWQDEHKYRKPTALSAPQYMNLLMDWIEVQINNEDIFPTNVGTPFPRNFLPVVKKILSRLFRVFVHVYIHHFDRITQMGSEAHVNTCYKHFYYFVKEFNLIDTKELEPLKEMTAQMCH", "length": 216 }, "evidence": [ { "id": "Q58D63", "url": "https://omabrowser.org/oma/group/Q58D63/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B5DEX8-1", "protein_name": "MOB kinase activator 3A", "gene_name": "Mob3a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSNPFLKQVFNKDKTFRPKRKFEPGTQRFELHKRAQASLNAGLDLRLAVQLPPGEDLNDWVAVHVVDFFNRVNLIYGTISDGCTEQSCPVMSGGPKYEYRWQDEQRYRKPTALSAPRYMDLLMDWIEVQINNEDLFPTNVGTPFPKTFLQAVRKILSRLFRVFVHVYIHHFDRIAQMGSEAHVNTCYKHFYYFVTEFSLIDPKELEPLKEMTSRMCH", "length": 217 }, "evidence": [ { "id": "Q58D63", "url": "https://omabrowser.org/oma/group/Q58D63/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S8I4-1", "protein_name": "MOB kinase activator 3A", "gene_name": "MOB3A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSNPFLLKQVFNKDKTFRPKRKFEPGTQRFELHKKAQASLNAGLDLKLAVQLPAGEELNDWVAVHVVDFFNRINLIYGTISDGCTERSCPIMSGGPKYEYRWQDENKFRRPTALSAPRYMDLLMDWVEVQINNEDVFPTNVGTPFPKNFLQVVKKILSRLFRVFVHVYIHHFDRIAQLGSEAHVNTCYKHFYYFVTEFGLIDTKELEPLKEMTARMCH", "length": 218 }, "evidence": [ { "id": "Q58D63", "url": "https://omabrowser.org/oma/group/Q58D63/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HFA6-1", "protein_name": "MOB kinase activator 3A", "gene_name": "Mob3a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSNPFLKQVFNKDKTFRPKRKFEPGTQRFELHKRAQASLNAGLDLRLAVQLPPGEDLNDWVAVHVVDFFNRVNLIYGTISDGCTEKSCPVMSGGPKYEYRWQDEQRYRKPTAVSAPRYMDLLMDWIEMQINNEDIFPTNVGTPFPKNFLQAVRKILSRLFRVFVHVYIHHFDRIAQMGSEAHVNTCYKHFYYFVTEFSLIDPKELEPLKEMTSRMCH", "length": 217 }, "evidence": [ { "id": "Q58D63", "url": "https://omabrowser.org/oma/group/Q58D63/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8BSU7-1", "protein_name": "MOB kinase activator 3A", "gene_name": "Mob3a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSNPFLKQVFNKDKTFRPKRKFEPGTQRFELHKRAQASLNAGLDLRLAVQLPPGEDLNDWVAVHVVDFFNRINLIYGTISDGCTEQSCPVMSGGPKYEYRWQDEQRFRKPTALSAPRYMDLLMDWIEVQINNEDIFPTNVGTPFPKTFLQAVRKILSRLFRVFVHVYIHHFDRIAQMGSEAHVNTCYKHFYYFVTEFNLIDPKELEPLKEMTSRMCH", "length": 217 }, "evidence": [ { "id": "Q58D63", "url": "https://omabrowser.org/oma/group/Q58D63/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96BX8-1", "protein_name": "MOB kinase activator 3A", "gene_name": "MOB3A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSNPFLKQVFNKDKTFRPKRKFEPGTQRFELHKKAQASLNAGLDLRLAVQLPPGEDLNDWVAVHVVDFFNRVNLIYGTISDGCTEQSCPVMSGGPKYEYRWQDEHKFRKPTALSAPRYMDLLMDWIEAQINNEDLFPTNVGTPFPKNFLQTVRKILSRLFRVFVHVYIHHFDRIAQMGSEAHVNTCYKHFYYFVKEFGLIDTKELEPLKEMTARMCH", "length": 217 }, "evidence": [ { "id": "Q58D63", "url": "https://omabrowser.org/oma/group/Q58D63/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q58D63", "url": "https://www.uniprot.org/uniprotkb/Q58D63" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58D63", "url": "https://www.uniprot.org/uniprotkb/Q58D63" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q58D63", "url": "https://www.uniprot.org/uniprotkb/Q58D63" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q58D63", "url": "https://www.uniprot.org/uniprotkb/Q58D63" } ], "pmid": "" }, { "name": "protein kinase activator activity", "id": "GO:0030295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030295", "evidence": [ { "database": "UniProtKB", "id": "Q58D63", "url": "https://www.uniprot.org/uniprotkb/Q58D63" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58D63-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 217, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58D63-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58D63" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q58D63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D63#function" }, { "id": "Q58D63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D63" }, { "id": "A0AAA9T564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T564#function" }, { "id": "A0AAA9T564", "database": 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q6RUW3-1", "uniprot_ac": "Q6RUW3", "uniprot_id": "NPY_BOVIN", "mass": { "chemical_mass": 10764.0, "monoisotopic_mass": 10764.0 }, "refseq": { "ac": "NP_001014845", "name": "pro-neuropeptide Y precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014845" }, "gene_names": [ { "name": "NPY", "type": "recommended", "evidence": [ { "id": "Q6RUW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ] }, { "name": "NPY", "type": "synonym", "evidence": [ { "id": "NP_001014845", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014845" } ] } ], "protein_names": [ { "name": "Pro-neuropeptide Y", "type": "recommended", "evidence": [ { "id": "Q6RUW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3/entry#names_and_taxonomy" } ] }, { "name": "NPY", "type": "synonym", "evidence": [ { "id": "Q6RUW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3/entry#names_and_taxonomy" } ] }, { "name": "Neuropeptide tyrosine", "type": "synonym", "evidence": [ { "id": "Q6RUW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3/entry#names_and_taxonomy" } ] }, { "name": "pro-neuropeptide Y precursor", "type": "synonym", "evidence": [ { "id": "NP_001014845", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014845" } ] }, { "name": "pro-neuropeptide Y", "type": "synonym", "evidence": [ { "id": "NP_001014845", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014845" } ] } ], "function": [ { "annotation": "Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin and hypothalamic neuropeptide Y (NPY) release.", "evidence": [ { "database": "RefSeq", "id": "NP_001014845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014845" }, { "database": "PubMed", "id": "25326602", "url": "https://glygen.org/publication/PubMed/25326602" } ] }, { "annotation": "Data show that PKA and PKC pathways are involved in the differential regulation of production of the neuropeptides (Met)enkephalin, galanin, somatostatin, NPY, and VIP.", "evidence": [ { "database": "RefSeq", "id": "NP_001014845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014845" }, { "database": "PubMed", "id": "18619673", "url": "https://glygen.org/publication/PubMed/18619673" } ] }, { "annotation": "Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin-NPY and insulin signaling pathways.", "evidence": [ { "database": "RefSeq", "id": "NP_001014845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014845" }, { "database": "PubMed", "id": "26231801", "url": "https://glygen.org/publication/PubMed/26231801" } ] }, { "annotation": "Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R). Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by NPY also leads to an increase of intracellular Ca(2+) levels. Is involved in the regulation of eating behaviour, acting as a stimulator of food intake (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3#function" }, { "database": "UniProtKB", "id": "P01303", "url": "https://www.uniprot.org/uniprotkb/P01303#function" }, { "database": "UniProtKB", "id": "P07808", "url": "https://www.uniprot.org/uniprotkb/P07808#function" }, { "database": "UniProtKB", "id": "P57774", "url": "https://www.uniprot.org/uniprotkb/P57774#function" } ] }, { "annotation": "NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YM98", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM98#function" }, { "database": "UniProtKB", "id": "ARBA00037434", "url": "https://www.uniprot.org/uniprotkb/ARBA00037434#function" } ] }, { "annotation": "NPY tended to increase serum growth hormone, which appeared to be a consequence of increased pulse amplitude. Infusion of NPY also increased CSF growth hormone-releasing hormone.", "evidence": [ { "database": "RefSeq", "id": "NP_001014845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014845" }, { "database": "PubMed", "id": "19632078", "url": "https://glygen.org/publication/PubMed/19632078" } ] }, { "annotation": "The NPY SNP (NPY1) was associated with the prevalence of the animal being in calf 100 d after calving and 305-d milk yield in the first lactation.", "evidence": [ { "database": "RefSeq", "id": "NP_001014845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014845" }, { "database": "PubMed", "id": "21700051", "url": "https://glygen.org/publication/PubMed/21700051" } ] }, { "annotation": "The effect of single nucleotide polymorphisms in 6 genes and their associations with production factors in beef cattle are reported.", "evidence": [ { "database": "RefSeq", "id": "NP_001014845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014845" }, { "database": "PubMed", "id": "17785604", "url": "https://glygen.org/publication/PubMed/17785604" } ] }, { "annotation": "There is a strong association between putative favorable allelic variants (SNP) of neuropeptide Y, leptin, and IGF-1 genes, and residual feed intake, when animals were grazing on a high-quality, high-availability pasture.", "evidence": [ { "database": "RefSeq", "id": "NP_001014845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014845" }, { "database": "PubMed", "id": "23881687", "url": "https://glygen.org/publication/PubMed/23881687" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NPY", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3", "locus": { "chromosome": "4", "start_pos": 71614020, "end_pos": 71761395, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004503", "url": "https://www.ensembl.org/id/ENSBTAG00000004503" } ] } } ], "crossref": [ { "id": "Q6RUW3", "url": "https://alphafold.ebi.ac.uk/entry/Q6RUW3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004503", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004503", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00126", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00126", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504216", "url": "https://www.ncbi.nlm.nih.gov/gene/504216", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001955", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001955", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504216", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504216", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YEDPAMW", "url": "https://omabrowser.org/oma/group/YEDPAMW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q6RUW3", "url": "https://www.orthodb.org/?gene=Q6RUW3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10533", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10533", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10533:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10533:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00159", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00159", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-375276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001014845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014845", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YM98", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YM98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YM98-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6RUW3-1", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGSKRLGLSGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAEDLARYYSALRHYINLITRQRYGKRSSPETLISDLLMRESTGNIPRTRLEDPSMW", "length": 97, "header": "sp|Q6RUW3-1|NPY_BOVIN Isoform 1 of Pro-neuropeptide Y OS=Bos taurus OX=9913 GN=NPY PE=3 SV=1 CANONICAL=Q6RUW3-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YM98-1", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3/entry#A0AAF6YM98-1", "sequence": { "sequence": "MMLGSKRLGLSGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAEDLARYYSALRHYINLITRQRYGKRSSPETLISDLLMRESTGNIPRTRLEDPSMW", "length": 98, "header": "tr|A0AAF6YM98-1|NPY_BOVIN Computationally mapped isoform of Pro-neuropeptide Y OS=Bos taurus OX=9913 GN=NPY PE=3 SV=1 CANONICAL=Q6RUW3-1" }, "locus": { "chromosome": "4", "start_pos": 71622750, "end_pos": 71617029, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081425.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081425.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066814.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066814.2" } ] } }, { "isoform_ac": "Q6RUW3-1", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3/entry#Q6RUW3-1", "sequence": { "sequence": "MLGSKRLGLSGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAEDLARYYSALRHYINLITRQRYGKRSSPETLISDLLMRESTGNIPRTRLEDPSMW", "length": 97, "header": "sp|Q6RUW3-1|NPY_BOVIN Isoform 1 of Pro-neuropeptide Y OS=Bos taurus OX=9913 GN=NPY PE=3 SV=1 CANONICAL=Q6RUW3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 83, "end_pos": 83, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "site_lbl": "Thr83" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Linkage mapping of NPY to bovine chromosome 4.", "journal": "Anim. Genet.", "date": "2004", "authors": "Thue T D, Buchanan F C", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "reference": [ { "type": "PubMed", "id": "15147401", "url": "https://glygen.org/publication/PubMed/15147401" } ] }, { "title": "Polymorphisms and haplotypes in the bovine neuropeptide Y, growth hormone receptor, ghrelin, insulin-like growth factor 2, and uncoupling proteins 2 and 3 genes and their associations with measures of growth, performance, feed efficiency, and carcass merit in beef cattle.", "journal": "Journal of animal science", "date": "2008-01", "authors": "Sherman E L, Nkrumah J D, Murdoch B M, Li C, Wang Z, Fu A, Moore S S", "evidence": [ { "database": "RefSeq", "id": "NP_001014845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014845" } ], "reference": [ { "type": "PubMed", "id": "17785604", "url": "https://glygen.org/publication/PubMed/17785604" } ] }, { "title": "Differential activation of enkephalin, galanin, somatostatin, NPY, and VIP neuropeptide production by stimulators of protein kinases A and C in neuroendocrine chromaffin cells.", "journal": "Neuropeptides", "date": "2008", "authors": "Hook Vivian, Toneff Thomas, Baylon Sheley, Sei Catherine", "evidence": [ { "database": "RefSeq", "id": "NP_001014845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014845" } ], "reference": [ { "type": "PubMed", "id": "18619673", "url": "https://glygen.org/publication/PubMed/18619673" } ] }, { "title": "Dynamics of GHRH in third-ventricle cerebrospinal fluid of cattle: relationship with serum concentrations of GH and responses to appetite-regulating peptides.", "journal": "Domestic animal endocrinology", "date": "2009-11", "authors": "Thomas M G, Amstalden M, Hallford D M, Silver G A, Garcia M D, Keisler D H, Williams G L", "evidence": [ { "database": "RefSeq", "id": "NP_001014845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014845" } ], "reference": [ { "type": "PubMed", "id": "19632078", "url": "https://glygen.org/publication/PubMed/19632078" } ] }, { "title": "Evidence that leptin genotype is associated with fertility, growth, and milk production in Holstein cows.", "journal": "Journal of dairy science", "date": "2011-07", "authors": "Clempson A M, Pollott G E, Brickell J S, Bourne N E, Munce N, Wathes D C", "evidence": [ { "database": "RefSeq", "id": "NP_001014845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014845" } ], "reference": [ { "type": "PubMed", "id": "21700051", "url": "https://glygen.org/publication/PubMed/21700051" } ] }, { "title": "Association of SNP of neuropeptide Y, leptin, and IGF-1 genes with residual feed intake in confinement and under grazing condition in Angus cattle.", "journal": "Journal of animal science", "date": "2013-09", "authors": "Trujillo A I, Casal A, Pe\u00f1agaricano F, Carriquiry M, Chilibroste P", "evidence": [ { "database": "RefSeq", "id": "NP_001014845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014845" } ], "reference": [ { "type": "PubMed", "id": "23881687", "url": "https://glygen.org/publication/PubMed/23881687" } ] }, { "title": "Reciprocal changes in leptin and NPY during nutritional acceleration of puberty in heifers.", "journal": "The Journal of endocrinology", "date": "2014-12", "authors": "Cardoso Rodolfo C, Alves Bruna R C, Prezotto Ligia D, Thorson Jennifer F, Tedeschi Luis O, Keisler Duane H, Amstalden Marcel, Williams Gary L", "evidence": [ { "database": "RefSeq", "id": "NP_001014845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014845" } ], "reference": [ { "type": "PubMed", "id": "25326602", "url": "https://glygen.org/publication/PubMed/25326602" } ] }, { "title": "Gene expression profiling of hormonal regulation related to the residual feed intake of Holstein cattle.", "journal": "Biochemical and biophysical research communications", "date": "2015-09-11", "authors": "Xi Y M, Yang Z, Wu F, Han Z Y, Wang G L", "evidence": [ { "database": "RefSeq", "id": "NP_001014845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014845" } ], "reference": [ { "type": "PubMed", "id": "26231801", "url": "https://glygen.org/publication/PubMed/26231801" } ] } ], "pathway": [ { "id": "bta:504216", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504216", "resource": "KEGG Pathway" }, { "id": "R-BTA-375276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375276", "resource": "Reactome", "description": "Peptide ligand-binding receptors" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MER3-1", "protein_name": "Pro-neuropeptide Y", "gene_name": "Npy", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLGSKRMGLCGLTLALSLLVCLGVLAEGYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLMKESTENVPRTRLEDPSMW", "length": 97 }, "evidence": [ { "id": "Q6RUW3", "url": "https://omabrowser.org/oma/group/Q6RUW3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P01303-1", "protein_name": "Pro-neuropeptide Y", "gene_name": "NPY", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLGNKRLGLSGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLMRESTENVPRTRLEDPAMW", "length": 97 }, "evidence": [ { "id": "Q6RUW3", "url": "https://omabrowser.org/oma/group/Q6RUW3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P07808-1", "protein_name": "Pro-neuropeptide Y", "gene_name": "Npy", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMLGNKRMGLCGLTLALSLLVCLGILAEGYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLMRESTENAPRTRLEDPSMW", "length": 98 }, "evidence": [ { "id": "Q6RUW3", "url": "https://omabrowser.org/oma/group/Q6RUW3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P28673-1", "protein_name": "Pro-neuropeptide Y", "gene_name": "NPY", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQGTMRLWVSVLTFALSLLICLGTLAEAYPSKPDSPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLLRESTENIPRSRFEDPSMW", "length": 97 }, "evidence": [ { "id": "Q6RUW3", "url": "https://omabrowser.org/oma/group/Q6RUW3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P57774-1", "protein_name": "Pro-neuropeptide Y", "gene_name": "Npy", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLGNKRMGLCGLTLALSLLVCLGILAEGYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLMKESTENAPRTRLEDPSMW", "length": 97 }, "evidence": [ { "id": "Q6RUW3", "url": "https://omabrowser.org/oma/group/Q6RUW3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "positive regulation of appetite", "id": "GO:0032100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032100", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "pmid": "" }, { "name": "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway", "id": "GO:0007193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007193", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "pmid": "" }, { "name": "positive regulation of cytosolic calcium ion concentration", "id": "GO:0007204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007204", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "pmid": "" }, { "name": "neuropeptide signaling pathway", "id": "GO:0007218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007218", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "pmid": "" }, { "name": "neuron projection development", "id": "GO:0031175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031175", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "pmid": "" }, { "name": "cerebral cortex development", "id": "GO:0021987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021987", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "pmid": "" }, { "name": "feeding behavior", "id": "GO:0007631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007631", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "pmid": "" }, { "name": "adult feeding behavior", "id": "GO:0008343", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008343", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "pmid": "" }, { "name": "central nervous system neuron development", "id": "GO:0021954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021954", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "pmid": "" }, { "name": "synaptic signaling via neuropeptide", "id": "GO:0099538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099538", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "GABA-ergic synapse", "id": "GO:0098982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098982", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "pmid": "" }, { "name": "neuronal dense core vesicle", "id": "GO:0098992", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098992", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "neuropeptide hormone activity", "id": "GO:0005184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005184", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "pmid": "" }, { "name": "neuropeptide Y receptor binding", "id": "GO:0031841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031841", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "pmid": "" }, { "name": "G protein-coupled receptor binding", "id": "GO:0001664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001664", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "pmid": "" }, { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "pmid": "" }, { "name": "neuropeptide activity", "id": "GO:0160041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160041", "evidence": [ { "database": "UniProtKB", "id": "Q6RUW3", "url": "https://www.uniprot.org/uniprotkb/Q6RUW3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], 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"table_stats": [ { "field": "total", "count": 8 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q863H2-1", "uniprot_ac": "Q863H2", "uniprot_id": "NCTR1_BOVIN", "mass": { "chemical_mass": 34494.0, "monoisotopic_mass": 34494.0 }, "refseq": { "ac": "NP_899209", "name": "natural cytotoxicity triggering receptor 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899209" }, "gene_names": [ { "name": "NCR1", "type": "recommended", "evidence": [ { "id": "Q863H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q863H2" } ] }, { "name": "NCR1", "type": "synonym", "evidence": [ { "id": "NP_899209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899209" } ] }, { "name": "NKP46", "type": "synonym", "evidence": [ { "id": "NP_899209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899209" } ] } ], "protein_names": [ { "name": "Natural cytotoxicity triggering 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"https://www.ncbi.nlm.nih.gov/protein/NP_899209" } ] }, { "name": "natural killer cell p46-related protein", "type": "synonym", "evidence": [ { "id": "NP_899209", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899209" } ] } ], "function": [ { "annotation": "Cytotoxicity activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.", "evidence": [ { "database": "UniProtKB", "id": "Q863H2", "url": "https://www.uniprot.org/uniprotkb/Q863H2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q863H2", "url": "https://www.uniprot.org/uniprotkb/Q863H2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NCR1", "url": "https://www.uniprot.org/uniprotkb/Q863H2", "locus": { "chromosome": "18", "start_pos": 62507268, "end_pos": 62516585, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000045529", "url": "https://www.ensembl.org/id/ENSBTAG00000045529" } ] } } ], "crossref": [ { "id": "Q863H2", "url": "https://alphafold.ebi.ac.uk/entry/Q863H2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000045529", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000045529", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "369024", "url": "https://www.ncbi.nlm.nih.gov/gene/369024", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:369024", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:369024", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ERRNTVM", "url": "https://omabrowser.org/oma/group/ERRNTVM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q863H2", "url": "https://www.orthodb.org/?gene=Q863H2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11738", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11738", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11738:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11738:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_899209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899209", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTK0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTK0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTK0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEK6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEK6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEK6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEK6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TND2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TND2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TND2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TND2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZMU7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZMU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZMU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZMU7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q863H2", "url": "https://www.uniprot.org/uniprotkb/Q863H2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q863H2-1", "url": "https://www.uniprot.org/uniprotkb/Q863H2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSTLAVFLVLGLGLSQRSSTQKQMLSKPAIWVRPSFMIPKGRSATIGCRGAGEAMEYQLHFEGGLSALKRPKSSPVMNWVKFPIPAMTSHTAGQYRCSYRSGELWSELSDPLELVVTGLYDTPTLSVEPRSEVTSGENVTFHCQLATATSTFFLLKKGRSSRPQLRYGNLRAEFHLGPVTPAHGGTYRCFGSYNNHAWSFPSKPVKLLVKVPGDAGDTTFAPTEHTSSDYWDSYELTTGTQSQKDHLLWNHMIQNLIRLGLAVLVLVALMGFLLEDWLHRRKSQERAHRASRRGCRRRLRAQRALET", "length": 308, "header": "sp|Q863H2-1|NCTR1_BOVIN Isoform 1 of Natural cytotoxicity triggering receptor 1 OS=Bos taurus OX=9913 GN=NCR1 PE=2 SV=1 CANONICAL=Q863H2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MTK0-1", "url": "https://www.uniprot.org/uniprotkb/Q863H2/entry#A0A3Q1MTK0-1", "sequence": { "sequence": "MPSTLAVFLVLGLGLSQRSSTQKQMLSKPAIWVRPSFMIPKGRSATIGCRGAGEAMEYQLHFEGGLSALKRPKSSPVMNWVKFPIPAMTSHTAGQYRCSYRSGELWSELSDPLELVVTGLYDTPTLSVEPRSEVTSGENVTFHCQLATATSTFFLLKKGRSSRPQLRYGNLRAEFHLGPVTPAHGGTYRCFGSYNNHAWSFPSKPVKLLVKVPGDAGDTTFAPTEHTSSDYWDSYELTTGTQSQKGSKDSCASFLQAKFSTTPIFPENSFNITATGIFPSSFCLYPYFFL", "length": 290, "header": "tr|A0A3Q1MTK0-1|NCTR1_BOVIN Computationally mapped isoform of Natural cytotoxicity triggering receptor 1 OS=Bos taurus OX=9913 GN=NCR1 PE=2 SV=2 CANONICAL=Q863H2-1" }, "locus": { "chromosome": "18", "start_pos": 62516386, "end_pos": 62511903, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077994.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077994.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057994.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057994.2" } ] } }, { "isoform_ac": "A0AAA9TEK6-1", "url": "https://www.uniprot.org/uniprotkb/Q863H2/entry#A0AAA9TEK6-1", "sequence": { "sequence": "MPSTLAVFLVLGLGLSQRSSTQKQMLSKPAIWVRPSFMIPKGRSATIGCRGAGEAMEYQLHFEGGLSALKRPKSSPVMNWVKFPIPAMTSHTAGQYRCSYRSGELWSELSDPLELVVTGLYDTPTLSVEPRSEVTSGENVTFHCQLATATSTFFLLKKGRSSRPQLRYGNLRAEFHLGPVTPAHGGTYRCFGSYNNHAWSFPSKPVKLLVKVPGDAGDTTFAPTEHTSSDYWDSYELTTGTQSQKGGAFITPAQDQCNPSSLLKAPMCLEIRFCRLMLVSWRSGKGIFLTQGSNLYLLHLLHWQAETTRGAGLEAEE", "length": 317, "header": "tr|A0AAA9TEK6-1|NCTR1_BOVIN Computationally mapped isoform of Natural cytotoxicity triggering receptor 1 OS=Bos taurus OX=9913 GN=NCR1 PE=2 SV=1 CANONICAL=Q863H2-1" }, "locus": { "chromosome": "18", "start_pos": 62516386, "end_pos": 62508272, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111304.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111304.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097040.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097040.1" } ] } }, { "isoform_ac": "A0AAA9TND2-1", "url": "https://www.uniprot.org/uniprotkb/Q863H2/entry#A0AAA9TND2-1", "sequence": { "sequence": "MPSTLAVFLVLGLGLSQRSSTQKQMLSKPAIWVRPSFMIPKGRSATIGCRGAGEAMEYQLHFEGGLSALKRPKSSPVMNWVKFPIPAMTSHTAGQYRCSYRSGELWSELSDPLELVVTGLYDTPTLSVEPRSEVTSGENVTFHCQLATATSTFFLLKKGRSSRPQLRYGNLRAEFHLGPVTPAHGGTYRCFGSYNNHAWSFPSKPVKLLVKVPGDAGDTTFAPTEHTSSDYWDSYELTTGTQSQKGGAFITPAQDQCNPSSLLKAPMCLEIRFCRLMLVSWRSGKGIFLTQGSNLYLLHLLHWQVGSLSPCHMGEVSMNIAKCPPEDKLRNYPVKNPWLGRI", "length": 342, "header": "tr|A0AAA9TND2-1|NCTR1_BOVIN Computationally mapped isoform of Natural cytotoxicity triggering receptor 1 OS=Bos taurus OX=9913 GN=NCR1 PE=2 SV=1 CANONICAL=Q863H2-1" }, "locus": { "chromosome": "18", "start_pos": 62516386, "end_pos": 62508457, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097146.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097146.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100029.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100029.1" } ] } }, { "isoform_ac": "A0AAF6ZMU7-1", "url": "https://www.uniprot.org/uniprotkb/Q863H2/entry#A0AAF6ZMU7-1", "sequence": { "sequence": "MPSTLAVFLVLEMLSKPAIWVRPSFMIPKGRSATIGCRGAGEAMEYQLHFEGGLSALKRPKSSPVMNWVKFPIPAMTSHTAGQYRCSYRSGELWSELSDPLELVVTGLYDTPTLSVEPRSEVTSGENVTFHCQLATATSTFFLLKKGRSSRPQLRYGNLRAEFHLGPVTPAHGGTYRCFGSYNNHAWSFPSKPVKLLVKVPGDAGDTTFAPTEHTSSDYWDSYELTTGTQSQKDHLLWNHMIQNLIRLGLAVLVLVALMGFLLEDWLHRRKSQERAHRASRRGCRRRLRAQRALET", "length": 296, "header": "tr|A0AAF6ZMU7-1|NCTR1_BOVIN Computationally mapped isoform of Natural cytotoxicity triggering receptor 1 OS=Bos taurus OX=9913 GN=NCR1 PE=2 SV=1 CANONICAL=Q863H2-1" }, "locus": { "chromosome": "18", "start_pos": 62516386, "end_pos": 62512227, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064403.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064403.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053976.2", "url": "https://www.ensembl.org/id/ENSBTAP00000053976.2" } ] } }, { "isoform_ac": "Q863H2-1", "url": "https://www.uniprot.org/uniprotkb/Q863H2/entry#Q863H2-1", "sequence": { "sequence": "MPSTLAVFLVLGLGLSQRSSTQKQMLSKPAIWVRPSFMIPKGRSATIGCRGAGEAMEYQLHFEGGLSALKRPKSSPVMNWVKFPIPAMTSHTAGQYRCSYRSGELWSELSDPLELVVTGLYDTPTLSVEPRSEVTSGENVTFHCQLATATSTFFLLKKGRSSRPQLRYGNLRAEFHLGPVTPAHGGTYRCFGSYNNHAWSFPSKPVKLLVKVPGDAGDTTFAPTEHTSSDYWDSYELTTGTQSQKDHLLWNHMIQNLIRLGLAVLVLVALMGFLLEDWLHRRKSQERAHRASRRGCRRRLRAQRALET", "length": 308, "header": "sp|Q863H2-1|NCTR1_BOVIN Isoform 1 of Natural cytotoxicity triggering receptor 1 OS=Bos taurus OX=9913 GN=NCR1 PE=2 SV=1 CANONICAL=Q863H2-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 139, "start_aa": "Asn", "end_pos": 139, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn139", "evidence": [ { "id": "Q863H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q863H2#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 181, "start_aa": "Thr", "end_pos": 181, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr181", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Natural killer cell receptors in cattle: a bovine killer cell immunoglobulin-like receptor multigene family contains members with divergent signaling motifs.", "journal": "Eur. J. Immunol.", "date": "2003", "authors": "Storset Anne K, Slettedal Imer O, Williams John L, Law Andy, Dissen Erik", "evidence": [ { "database": "UniProtKB", "id": "Q863H2", "url": "https://www.uniprot.org/uniprotkb/Q863H2" } ], "reference": [ { "type": "PubMed", "id": "12672064", "url": "https://glygen.org/publication/PubMed/12672064" } ] } ], "pathway": [ { "id": "bta:369024", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:369024", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O76036-1", "protein_name": "Natural cytotoxicity triggering receptor 1", "gene_name": "NCR1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSTLPALLCVGLCLSQRISAQQQTLPKPFIWAEPHFMVPKEKQVTICCQGNYGAVEYQLHFEGSLFAVDRPKPPERINKVQFYIPDMNSRMAGQYSCIYRVGELWSEPSNLLDLVVTEMYDTPTLSVHPGPEVISGEKVTFYCRLDTATSMFLLLKEGRSSHVQRGYGKVQAEFPLGPVTTAHRGTYRCFGSYNNHAWSFPSEPVKLLVTGDIENTSLAPEDPTFPADTWGTYLLTTETGLQKDHALWDHTAQNLLRMGLAFLVLVALVWFLVEDWLSRKRTRERASRASTWEGRRRLNTQTL", "length": 304 }, "evidence": [ { "id": "Q863H2", "url": "https://omabrowser.org/oma/group/Q863H2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C567-1", "protein_name": "Natural cytotoxicity triggering receptor 1", "gene_name": "Ncr1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPTLTALLCLGLCLSQRINTEKETLPKPIIWAKPSIMVTNGNSVNIWCQGAQSASEYQLYFEGSFFALERPKPSRSMNKVRFFISQMTSHTAGIYTCFYQSGELWSKSSNPLKLVVTGLYDTPNLWVYPRPEVTLGENVTFFCQLKTATSKFFLLKERGSNHIQNKYGNIQAEFPMGPVTRAHRGTYRCFGSYNDYAWSFPSEPVTLLITGGVENSSLAPTDPTSSLDYWEFDLSTNESGLQKDSAFWDHTTQNLIRIGLACIILITLVWLLTEDWLSKRKDHEEANRLTNWECRRRWRMQHYFEEEQRNAISMMELKATPGAL", "length": 325 }, "evidence": [ { "id": "Q863H2", "url": "https://omabrowser.org/oma/group/Q863H2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "immune response-inhibiting cell surface receptor signaling pathway", "id": "GO:0002767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002767", "evidence": [ { "database": "UniProtKB", "id": "Q863H2", "url": "https://www.uniprot.org/uniprotkb/Q863H2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transmembrane signaling receptor activity", "id": "GO:0004888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "evidence": [ { "database": "UniProtKB", "id": "Q863H2", "url": "https://www.uniprot.org/uniprotkb/Q863H2" } ], "pmid": "" }, { "name": "immune receptor activity", "id": "GO:0140375", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140375", "evidence": [ { "database": "UniProtKB", "id": "Q863H2", "url": "https://www.uniprot.org/uniprotkb/Q863H2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q863H2", "url": "https://www.uniprot.org/uniprotkb/Q863H2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 139, "end_pos": 141, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q863H2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 308, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q863H2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q863H2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 139 ], "o_linked_sites": [ 181 ], 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"categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015665", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TW25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW25-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YN63", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YN63-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN63-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9K7", "url": "https://www.uniprot.org/uniprotkb/Q5E9K7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9K7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9K7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRRSSRLQAKQQPQASQTDSPQEAQIIQAKKRKTAQDVKKRKEEVTKKHQYEIRNCWPPVLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSQDVWLNMLKKETRYVHDKHFEVLHSELEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELAILKALKWELCPVTVISWLNLFLQVDALKDAPKVLLPQYSQEKFIQIAQLLDLCILAIDSLEFQYRILAAAALCHFTSIEVVKKASGLEWDNISECVDWMVPFVSVVKSTSPAKLKIFKKISMEDRHNIQTHTNYLAMLDEVNYVNTFRKEGQLSPVCNGGIMTPPKSTEKPPGKH", "length": 404, "header": "sp|Q5E9K7-1|CCNE2_BOVIN Isoform 1 of G1/S-specific cyclin-E2 OS=Bos taurus OX=9913 GN=CCNE2 PE=2 SV=1 CANONICAL=Q5E9K7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TW25-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9K7/entry#A0AAA9TW25-1", "sequence": { "sequence": 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"https://www.uniprot.org/uniprotkb/Q5E9K7/entry#A0AAF6YN63-1", "sequence": { "sequence": "MSRRSRLQAKQQPQASQTDSPQEAQIIQAKKRKTAQDVKKRKEEVTKKHQYEIRNCWPPVLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSQDVWLNMLKKETRYVHDKHFEVLHSELEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELAILKALKWELCPVTVISWLNLFLQVDALKDAPKVLLPQYSQEKFIQIAQLLDLCILAIDSLEFQYRILAAAALCHFTSIEVVKKASGLEWDNISECVDWMVPFVSVVKSTSPAKLKIFKKISMEDRHNIQTHTNYLAMLDEVNYVNTFRKEGQLSPVCNGGIMTPPKSTEKPPGKH", "length": 403, "header": "tr|A0AAF6YN63-1|CCNE2_BOVIN Computationally mapped isoform of G1/S-specific cyclin-E2 OS=Bos taurus OX=9913 GN=CCNE2 PE=2 SV=1 CANONICAL=Q5E9K7-1" }, "locus": { "chromosome": "14", "start_pos": 69459440, "end_pos": 69449259, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006455.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006455.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006455.7", "url": "https://www.ensembl.org/id/ENSBTAP00000006455.7" } ] } }, { "isoform_ac": "Q5E9K7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9K7/entry#Q5E9K7-1", "sequence": { "sequence": "MSRRSSRLQAKQQPQASQTDSPQEAQIIQAKKRKTAQDVKKRKEEVTKKHQYEIRNCWPPVLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSQDVWLNMLKKETRYVHDKHFEVLHSELEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELAILKALKWELCPVTVISWLNLFLQVDALKDAPKVLLPQYSQEKFIQIAQLLDLCILAIDSLEFQYRILAAAALCHFTSIEVVKKASGLEWDNISECVDWMVPFVSVVKSTSPAKLKIFKKISMEDRHNIQTHTNYLAMLDEVNYVNTFRKEGQLSPVCNGGIMTPPKSTEKPPGKH", "length": 404, "header": "sp|Q5E9K7-1|CCNE2_BOVIN Isoform 1 of G1/S-specific cyclin-E2 OS=Bos taurus OX=9913 GN=CCNE2 PE=2 SV=1 CANONICAL=Q5E9K7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 21, "end_pos": 21, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9K7", "url": "https://www.uniprot.org/uniprotkb/Q5E9K7" } ], "site_lbl": "Ser21" }, { "start_pos": 383, "end_pos": 383, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9K7", "url": "https://www.uniprot.org/uniprotkb/Q5E9K7" } ], "site_lbl": "Ser383" }, { "start_pos": 392, "end_pos": 392, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9K7", "url": "https://www.uniprot.org/uniprotkb/Q5E9K7" } ], "site_lbl": "Thr392" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9K7", "url": "https://www.uniprot.org/uniprotkb/Q5E9K7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:538436", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538436", "resource": "KEGG Pathway" }, { "id": "R-BTA-1538133", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1538133", "resource": "Reactome", "description": "G0 and Early G1" }, { "id": "R-BTA-187577", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-187577", "resource": "Reactome", "description": "SCF(Skp2)-mediated degradation of p27/p21" }, { "id": "R-BTA-2559586", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559586", "resource": "Reactome", "description": "DNA Damage/Telomere Stress Induced Senescence" }, { "id": "R-BTA-6804116", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804116", "resource": "Reactome", "description": "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest" }, { "id": "R-BTA-69017", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69017", "resource": "Reactome", "description": "CDK-mediated phosphorylation and removal of Cdc6" }, { "id": "R-BTA-69200", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69200", "resource": "Reactome", "description": "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes" }, { "id": "R-BTA-69202", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69202", "resource": "Reactome", "description": "Cyclin E associated events during G1/S transition" }, { "id": "R-BTA-69231", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69231", "resource": "Reactome", "description": "Cyclin D associated events in G1" }, { "id": "R-BTA-69563", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69563", "resource": "Reactome", "description": "p53-Dependent G1 DNA Damage Response" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YML2-1", "protein_name": "Cyclin E2", "gene_name": "CCNE2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSRRSSRLQAKQQQQPPLPCQEETPRELQAPEHLQTRKRRTAEQEIKKKEDGKIAKKHQYEIKSCWPPTITGGISPCIIIETPHKESVTTDFSRFKKYRFRNLFINPSPLPELTWGNSKDVWLNILKKENRYAHCKHFTSLHSSLQPHMRSILLDWLLEVCEVYALHRETFYLAQDFFDRFMLTQKNINKSMLQLIGITSLFIASKLEEIYAPKIQEFAYVTDGACSEDDIVRMELIMLKALKWELCPVTIISWLNLYLQVDALKDVPKVLLPQYSQEKFIQIAQLLDLCILDVNSLDFQYRTLAAAALCHYTSTEVVKKASGLDWDNISECVEWMVPFVNVARKVSVKLKHFKKVAVEDCHNIQTHTNYLDMLEEVNSGVASTAPGQLSPVSTAGIITPPKSTEKK", "length": 407 }, "evidence": [ { "id": "Q5E9K7", "url": "https://omabrowser.org/oma/group/Q5E9K7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZQ41-1", "protein_name": "Cyclin E2", "gene_name": "Ccne2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRRSSRLQAKQQHARPNQPDSPQEAQIIQAKKRKTAQDVKKRTEEITKKHQYEIRNCWPPVLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWACSQEVWQNMLQKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDVNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALKWELCPVTVISWLNLFLQVDAVKDIPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILAAAALCHFTSIEVVKKASGLEWDDISECVDWMVPFVSVVKSVSPVKLKTFKKIPMEDRHNIQTHTNYLALLNEVNYVNIFRKGGQLSPVCNGGIMTPPKSTEKPPVKF", "length": 405 }, "evidence": [ { "id": "Q5E9K7", "url": "https://omabrowser.org/oma/group/Q5E9K7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RY56-1", "protein_name": "Cyclin E2", "gene_name": "CCNE2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": 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1, "go_terms": [ { "name": "cyclin-dependent protein serine/threonine kinase regulator activity", "id": "GO:0016538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016538", "evidence": [ { "database": "UniProtKB", "id": "Q5E9K7", "url": "https://www.uniprot.org/uniprotkb/Q5E9K7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 320, "end_pos": 322, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9K7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 404, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9K7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9K7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], 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"twinfilin-1", "type": "synonym", "evidence": [ { "id": "NP_001020491", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020491" } ] } ], "function": [ { "annotation": "Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NES9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NES9#function" }, { "database": "UniProtKB", "id": "ARBA00037775", "url": "https://www.uniprot.org/uniprotkb/ARBA00037775#function" }, { "database": "UniProtKB", "id": "A0AAA9T6T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6T9#function" }, { "database": "UniProtKB", "id": "A0A452DJ17", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ17#function" }, { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6#function" } ] }, { "annotation": "The results reveal that TWF1 is highly induced by the stimulation of amino acids and hormones and involved in regulation of milk bio-synthesis and cell proliferation via the mTOR pathway in bovine mammary epithelial cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001020491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020491" }, { "database": "PubMed", "id": "28864421", "url": "https://glygen.org/publication/PubMed/28864421" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TWF1", "url": "https://www.uniprot.org/uniprotkb/Q56JV6", "locus": { "chromosome": "5", "start_pos": 36662093, "end_pos": 36650432, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020938", "url": "https://www.ensembl.org/id/ENSBTAG00000020938" } ] } } ], "crossref": [ { "id": "Q56JV6", "url": "https://alphafold.ebi.ac.uk/entry/Q56JV6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020938", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020938", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11284", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11284", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11285", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11285", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506683", "url": "https://www.ncbi.nlm.nih.gov/gene/506683", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028458", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028458", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506683", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506683", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NES9", "url": "https://www.orthodb.org/?gene=A0A3Q1NES9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJ17", "url": "https://www.orthodb.org/?gene=A0A452DJ17", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q56JV6", "url": "https://www.orthodb.org/?gene=Q56JV6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13759", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13759", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13759:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13759:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00241", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00241", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9013418", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013418", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001020491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020491", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NES9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NES9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NES9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NES9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ17", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ17-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ17-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6T9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6T9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6T9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6T9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JV6-1", "url": "https://www.uniprot.org/uniprotkb/Q56JV6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSHQTGIQASEDVKDIFARARNGKYRLLKISIENEKLVIGSCRKPSDSWDQDYDSFVLPLLEDKQPCYVLFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEMFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINEVQTDVSVDAKHQTLQGVAFPISQEAFQALEKLNNRQLNYVQLEIDIKNEIIILANTINTELKDLPKRIPKDAARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSPLLEIVERQLQMDIIRKIEIDNGDELTADFLYEEVHPKQHAHKQSFAKPKGPSGKRGIRRIIRGPAETEATTE", "length": 350, "header": "sp|Q56JV6-1|TWF1_BOVIN Isoform 1 of Twinfilin-1 OS=Bos taurus OX=9913 GN=TWF1 PE=2 SV=1 CANONICAL=Q56JV6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NES9-1", "url": "https://www.uniprot.org/uniprotkb/Q56JV6/entry#A0A3Q1NES9-1", "sequence": { "sequence": "MHDLATEQQQQQQKPCSVSASEDVKDIFARARNGKYRLLKISIENEKLVIGSCRKPSDSWDQDYDSFVLPLLEDKQPCYVLFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEMFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINEVQTDVSVDAKHQTLQGVAFPISQEAFQALEKLNNRQLNYVQLEIDIKNEIIILANTINTELKDLPKRIPKDAARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSPLLEIVERQLQMDIIRKIEIDNGDELTADFLYEEVHPKQHAHKQSFAKPKGPSGKRGIRRIIRGPAETEATTE", "length": 361, "header": "tr|A0A3Q1NES9-1|TWF1_BOVIN Computationally mapped isoform of Twinfilin-1 OS=Bos taurus OX=9913 GN=TWF1 PE=2 SV=2 CANONICAL=Q56JV6-1" }, "locus": { "chromosome": "5", "start_pos": 36661939, "end_pos": 36652354, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077000.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077000.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070174.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070174.2" } ] } }, { "isoform_ac": "A0A452DJ17-1", "url": "https://www.uniprot.org/uniprotkb/Q56JV6/entry#A0A452DJ17-1", "sequence": { "sequence": "MTRRGRRRSGHFLEPPAGAARCTQRWSREPAAAAMSHQTGIQASEDVKDIFARARNGKYRLLKISIENEKLVIGSCRKPSDSWDQDYDSFVLPLLEDKQPCYVLFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEMFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINEVQTDVSVDAKHQTLQGVAFPISQEAFQALEKLNNRQLNYVQLEIDIKNEIIILANTINTELKDLPKRIPKDAARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSPLLEIVERQLQMDIIRKIEIDNGDELTADFLYEEVHPKQHAHKQSFAKPKGPSGKRGIRRIIRGPAETEATTE", "length": 384, "header": "tr|A0A452DJ17-1|TWF1_BOVIN Computationally mapped isoform of Twinfilin-1 OS=Bos taurus OX=9913 GN=TWF1 PE=2 SV=1 CANONICAL=Q56JV6-1" }, "locus": { "chromosome": "5", "start_pos": 36661939, "end_pos": 36650631, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027889.8", "url": "https://www.ensembl.org/id/ENSBTAT00000027889.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027889.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027889.6" } ] } }, { "isoform_ac": "A0AAA9T6T9-1", "url": "https://www.uniprot.org/uniprotkb/Q56JV6/entry#A0AAA9T6T9-1", "sequence": { "sequence": "MSHQTGIQASEDVKDIFARARNGKYRLLKISIENEKLVIGSCRKPSDSWDQDYDSFVLPLLEDKQPCYVLFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEMFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINENPEDLIGVQTDVSVDAKHQTLQGVAFPISQEAFQALEKLNNRQLNYVQLEIDIKNEIIILANTINTELKDLPKRIPKDAARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSPLLEIVERQLQMDIIRKIEIDNGDELTADFLYEEVHPKQHAHKQSFAKPKGPSGKRGIRRIIRGPAETEATTE", "length": 357, "header": "tr|A0AAA9T6T9-1|TWF1_BOVIN Computationally mapped isoform of Twinfilin-1 OS=Bos taurus OX=9913 GN=TWF1 PE=2 SV=1 CANONICAL=Q56JV6-1" }, "locus": { "chromosome": "5", "start_pos": 36661939, "end_pos": 36650733, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128245.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128245.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091502.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091502.1" } ] } }, { "isoform_ac": "Q56JV6-1", "url": "https://www.uniprot.org/uniprotkb/Q56JV6/entry#Q56JV6-1", "sequence": { "sequence": "MSHQTGIQASEDVKDIFARARNGKYRLLKISIENEKLVIGSCRKPSDSWDQDYDSFVLPLLEDKQPCYVLFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEMFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINEVQTDVSVDAKHQTLQGVAFPISQEAFQALEKLNNRQLNYVQLEIDIKNEIIILANTINTELKDLPKRIPKDAARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSPLLEIVERQLQMDIIRKIEIDNGDELTADFLYEEVHPKQHAHKQSFAKPKGPSGKRGIRRIIRGPAETEATTE", "length": 350, "header": "sp|Q56JV6-1|TWF1_BOVIN Isoform 1 of Twinfilin-1 OS=Bos taurus OX=9913 GN=TWF1 PE=2 SV=1 CANONICAL=Q56JV6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 143, "end_pos": 143, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "site_lbl": "Ser143" }, { "start_pos": 277, "end_pos": 277, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "site_lbl": "Ser277" }, { "start_pos": 309, "end_pos": 309, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "site_lbl": "Tyr309" }, { "start_pos": 349, "end_pos": 349, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "site_lbl": "Thr349" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Twinfilin 1 enhances milk bio-synthesis and proliferation of bovine mammary epithelial cells via the mTOR signaling pathway.", "journal": "Biochemical and biophysical research communications", "date": "2017-10-21", "authors": "Li Lu, Liu Lijie, Qu Bo, Li Xueying, Gao Xuejun, Zhang Minghui", "evidence": [ { "database": "RefSeq", "id": "NP_001020491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020491" } ], "reference": [ { "type": "PubMed", "id": "28864421", "url": "https://glygen.org/publication/PubMed/28864421" } ] } ], "pathway": [ { "id": "bta:506683", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506683", "resource": "KEGG Pathway" }, { "id": "R-BTA-9013418", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013418", "resource": "Reactome", "description": "RHOBTB2 GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" }, { "name": "actin monomer binding", "id": "GO:0003785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003785", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" }, { "name": "protein tyrosine kinase activity", "id": "GO:0004713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004713", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" }, { "name": "phosphatidylinositol-4,5-bisphosphate binding", "id": "GO:0005546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" }, { "name": "actin filament", "id": "GO:0005884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005884", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" }, { "name": "myofibril", "id": "GO:0030016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030016", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" }, { "name": "filopodium", "id": "GO:0030175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030175", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" }, { "name": "ruffle membrane", "id": "GO:0032587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032587", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "positive regulation of neuron projection development", "id": "GO:0010976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010976", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" }, { "name": "barbed-end actin filament capping", "id": "GO:0051016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051016", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" }, { "name": "regulation of lamellipodium assembly", "id": "GO:0010591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010591", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" }, { "name": "actin filament depolymerization", "id": "GO:0030042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030042", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" }, { "name": "negative regulation of actin filament polymerization", "id": "GO:0030837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030837", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" }, { "name": "positive regulation of cardiac muscle hypertrophy", "id": "GO:0010613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010613", "evidence": [ { "database": "UniProtKB", "id": "Q56JV6", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q56JV6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 350, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q56JV6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q56JV6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q56JV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" }, { "id": "PRU00599", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00599" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ADF-H 1", "eco_id": "ECO_0000255", "start_pos": 2, "end_pos": 139, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q56JV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV6" }, { "id": "PRU00599", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00599" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ADF-H 2", "eco_id": "ECO_0000255", "start_pos": 177, "end_pos": 313, "start_aa": "Gly", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 143, 277, 309, 349 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": 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"table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58CV6-1", "uniprot_ac": "Q58CV6", "uniprot_id": "KLDC3_BOVIN", "mass": { "chemical_mass": 43058.0, "monoisotopic_mass": 43058.0 }, "refseq": { "ac": "NP_001014966", "name": "kelch domain-containing protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014966" }, "gene_names": [ { "name": "KLHDC3", "type": "recommended", "evidence": [ { "id": "Q58CV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CV6" } ] }, { "name": "RRP36", "type": "recommended", "evidence": [ { "id": "Q58CV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CV6" } ] }, { "name": "KLHDC3", "type": "synonym", "evidence": [ { "id": "NP_001014966", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014966" } ] } ], "protein_names": [ { "name": "Kelch domain-containing protein 3", "type": "recommended", "evidence": [ { "id": "Q58CV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CV6/entry#names_and_taxonomy" } ] }, { "name": "kelch domain-containing protein 3", "type": "synonym", "evidence": [ { "id": "NP_001014966", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014966" } ] } ], "function": [ { "annotation": "Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA.", "evidence": [ { "database": "UniProtKB", "id": "A6QNR1", "url": "https://www.uniprot.org/uniprotkb/A6QNR1#function" } ] }, { "annotation": "Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons. The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine. May be involved in meiotic recombination process.", "evidence": [ { "database": "UniProtKB", "id": "Q58CV6", "url": "https://www.uniprot.org/uniprotkb/Q58CV6#function" }, { "database": "UniProtKB", "id": "Q9BQ90", "url": "https://www.uniprot.org/uniprotkb/Q9BQ90#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CV6", "url": "https://www.uniprot.org/uniprotkb/Q58CV6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KLHDC3", "url": "https://www.uniprot.org/uniprotkb/Q58CV6", "locus": { "chromosome": "23", "start_pos": 16661311, "end_pos": 16657261, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050696", "url": "https://www.ensembl.org/id/ENSBTAG00000050696" } ] } } ], "crossref": [ { "id": "Q58CV6", "url": "https://alphafold.ebi.ac.uk/entry/Q58CV6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050696", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050696", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000053873", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000053873", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100125879", "url": "https://www.ncbi.nlm.nih.gov/gene/100125879", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "541138", "url": "https://www.ncbi.nlm.nih.gov/gene/541138", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009292", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009292", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052637", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052637", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100125879", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100125879", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "bta:541138", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541138", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CRNVEQK", "url": "https://omabrowser.org/oma/group/CRNVEQK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "SQETYVF", "url": "https://omabrowser.org/oma/group/SQETYVF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QNR1", "url": "https://www.orthodb.org/?gene=A6QNR1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6QVR6", "url": "https://www.orthodb.org/?gene=F6QVR6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q58CV6", "url": "https://www.orthodb.org/?gene=Q58CV6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21738", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21738", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21738:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21738:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46461", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46461", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46461:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46461:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06102", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06102", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24681", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24681", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001014966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014966", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9THT7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THT7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THT7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QNR1", "url": "https://www.uniprot.org/uniprotkb/A6QNR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QNR1-1", "url": "https://www.uniprot.org/uniprotkb/A6QNR1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QVR6", "url": "https://www.uniprot.org/uniprotkb/F6QVR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QVR6-1", "url": "https://www.uniprot.org/uniprotkb/F6QVR6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CV6", "url": "https://www.uniprot.org/uniprotkb/Q58CV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CV6-1", "url": "https://www.uniprot.org/uniprotkb/Q58CV6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CV6-2", "url": "https://www.uniprot.org/uniprotkb/Q58CV6-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVRPAARGQAPVVPYMRYGHSTVLIDDTVFLWGGRNDTEGACNVLYAFDVNTHKWSTPRVSGTVPGARDGHSACVLGKTMYIFGGYEQLADCFSNDIHKLDTSTMTWTLICTKGNPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDIRWELNAMTTNSNISRPIVSSHG", "length": 382, "header": "sp|Q58CV6-1|KLDC3_BOVIN Isoform 1 of Kelch domain-containing protein 3 OS=Bos taurus OX=9913 GN=KLHDC3 PE=2 SV=2 CANONICAL=Q58CV6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9THT7-1", "url": "https://www.uniprot.org/uniprotkb/Q58CV6/entry#A0AAA9THT7-1", "sequence": { "sequence": "MDTQPSSSMTQSSFGAGGMTPKGPAMCSMPLMSADCFSNDIHKLDTSTMTWTLICTKGNPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDIRWELNAMTTNSNISRPIVSSHG", "length": 266, "header": "tr|A0AAA9THT7-1|KLDC3_BOVIN Computationally mapped isoform of Kelch domain-containing protein 3 OS=Bos taurus OX=9913 GN=KLHDC3 PE=2 SV=2 CANONICAL=Q58CV6-1" }, "locus": { "chromosome": "23", "start_pos": 16660739, "end_pos": 16657758, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130448.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130448.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096653.2", "url": "https://www.ensembl.org/id/ENSBTAP00000096653.2" } ] } }, { "isoform_ac": "A6QNR1-1", "url": "https://www.uniprot.org/uniprotkb/Q58CV6/entry#A6QNR1-1", "sequence": { "sequence": "MRRASSCGGAVAGSPSEAQDGGEDDGSLRNDTSHMSFEELLELQSQVGTKAYKQLVTGSSTKKQSSRPPVQKGCVADKHRPLEMSAKVRVPFLRQVVPISKKVARDPRFDDLSGEYNPEVFDKTYQFLDDIRAREKELVKKQLKKHRSGEEHEKLQHLLQRMEQQEMAQKERKRQQELRLALKQERRAQAQQGHRPYFLKKSEQRQLVLAEKFKELKRSKKLESFLSRKRRRNAGKDRRHLPLSKE", "length": 246, "header": "sp|A6QNR1-1|KLDC3_BOVIN Computationally mapped isoform of Kelch domain-containing protein 3 OS=Bos taurus OX=9913 GN=KLHDC3 PE=2 SV=1 CANONICAL=Q58CV6-1" }, "locus": {} }, { "isoform_ac": "F6QVR6-1", "url": "https://www.uniprot.org/uniprotkb/Q58CV6/entry#F6QVR6-1", "sequence": { "sequence": "MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVRPAARGQAPVVPYMRYGHSTVLIDDTVFLWGGRNDTEGACNVLYAFDVNTHKWSTPRVSGTVPGARDGHSACVLGKTMYIFGGYEQLADCFSNDIHKLDTSTMTWTLICTKGNPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTRSGGEKGGPEPLGVKRLPRERVGVPNLSPSLKTLCKLAVIQYNLDQSCLPHDIRWELNAMTTNSNISRPIVSSHG", "length": 384, "header": "tr|F6QVR6-1|KLDC3_BOVIN Computationally mapped isoform of Kelch domain-containing protein 3 OS=Bos taurus OX=9913 GN=KLHDC3 PE=2 SV=1 CANONICAL=Q58CV6-1" }, "locus": { "chromosome": "23", "start_pos": 16660739, "end_pos": 16657320, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016944.6", "url": "https://www.ensembl.org/id/ENSBTAT00000016944.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016944.4", "url": "https://www.ensembl.org/id/ENSBTAP00000016944.4" } ] } }, { "isoform_ac": "Q58CV6-1", "url": "https://www.uniprot.org/uniprotkb/Q58CV6/entry#Q58CV6-1", "sequence": { "sequence": "MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVRPAARGQAPVVPYMRYGHSTVLIDDTVFLWGGRNDTEGACNVLYAFDVNTHKWSTPRVSGTVPGARDGHSACVLGKTMYIFGGYEQLADCFSNDIHKLDTSTMTWTLICTKGNPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDIRWELNAMTTNSNISRPIVSSHG", "length": 382, "header": "sp|Q58CV6-1|KLDC3_BOVIN Isoform 1 of Kelch domain-containing protein 3 OS=Bos taurus OX=9913 GN=KLHDC3 PE=2 SV=2 CANONICAL=Q58CV6-1" }, "locus": { "chromosome": "23", "start_pos": 16660739, "end_pos": 16657320, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016943.6", "url": "https://www.ensembl.org/id/ENSBTAT00000016943.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016943.3", "url": "https://www.ensembl.org/id/ENSBTAP00000016943.3" } ] } }, { "isoform_ac": "Q58CV6-2", "url": "https://www.uniprot.org/uniprotkb/Q58CV6/entry#Q58CV6-2", "sequence": { "sequence": "MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVRPAARGQAPVVPYMRYGHSTVLIDDTVFLWGGRNDTEGACNVLYAFDVNTHKWSTPRVSGTVPGARDGHSACVLGKTMYIFGGYEQLADCFSNDIHKLDTSTMTWTLICTKGNPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDIRYSEWLEGRD", "length": 370, "header": "sp|Q58CV6-2|KLDC3_BOVIN Isoform 2 of Kelch domain-containing protein 3 OS=Bos taurus OX=9913 GN=KLHDC3 PE=2 SV=2 CANONICAL=Q58CV6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CV6", "url": "https://www.uniprot.org/uniprotkb/Q58CV6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:100125879", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100125879", "resource": "KEGG Pathway" }, { "id": "bta:541138", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541138", "resource": "KEGG Pathway" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z053-1", "protein_name": "Neuronal PAS domain protein 4", "gene_name": "NPAS4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTVFCSHCHRPLQAETSCLPRRAEQAHGASKPFRSTKSASKARRDQINAELHALRSLLPISTQEKERLSYLHTMALVCLRLRGAHLFPPASAPPSGPVLAAELLSLLPGFLLVLSAGGKLVYISENVSQFLGLSMVELLAHGDTIFDILDGQAREDVHKKLLLAQEQPGREITFVSEMRTSKAFRLQRGGNQAVAVRGHFMVPHWPASPSTTAFLALCTPAAQLDADRDTGSQDNLFQSTHALDMRFMDVTESAIYHLGYLREELIGRSWYSLLHPEDADVAAAQHRAVALGAGAVAGPVVLRVLRRDRTWAWLCVTARRGGRCITCTSRSLR", "length": 333 }, "evidence": [ { "id": "Q58CV6", "url": "https://omabrowser.org/oma/group/Q58CV6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A5GFR3-1", "protein_name": "Kelch domain-containing protein 3", "gene_name": "KLHDC3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVRPATRGQAPVVPYMRYGHSTVLIDDTVFLWGGRNDTEGACNVLYAFDVNTHKWSTPRVAGTVPGARDGHSACVLGKTMYIFGGYEQLADCFSNDIHKLDTSTMTWTLICTKGNPARWRDFHSATMLGNHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDIRWELNAMTTNSNISRPIVSSHG", "length": 382 }, "evidence": [ { "id": "Q58CV6", "url": "https://omabrowser.org/oma/group/Q58CV6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HR72-1", "protein_name": "Kelch domain-containing protein 3", "gene_name": "Klhdc3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVRPAVRGQPPVVPYMRYGHSTVLIDDTVFLWGGRNDTEGACNVLYAFDVNTHKWSTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQLADCFSNDIHKLDTSTMTWTLVCTKGNPARWRDFHSATMLGNHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPHTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPGSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDIRWELNAMTTNSNISRPIVSSHG", "length": 382 }, "evidence": [ { "id": "Q58CV6", "url": "https://omabrowser.org/oma/group/Q58CV6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q3UFY0-1", "protein_name": "Ribosomal RNA processing protein 36 homolog", "gene_name": "Rrp36", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRKAGSRARAEAEGPHRAMEGGEVTGDRLKADTPDVSFEELLRLQGQGRPKAHKQLVAGNSTRTRSPQQPVCVADKHRPLEMSAKVRVPFLRQVVPISKKVARDPRFDDLSGDYNPEVFDKTYQFLNDIRAKEKQLVKKQLKRHRSGEERDKLQQLLQRMEQQEMAQQERKQQQELRLALKQERRAQAQQGHRPYFLKKSEQRQLALAEKFKELRRSKKLESFLSRKRRRNAGKDRRHLPLSKE", "length": 244 }, "evidence": [ { "id": "Q58CV6", "url": "https://omabrowser.org/oma/group/Q58CV6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6AYI2-1", "protein_name": "Kelch domain-containing protein 3", "gene_name": "Klhdc3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVRPAVRGQAPVVPYMRYGHSTVLIDDTVFLWGGRNDTEGACNVLYAFDVNTHKWSTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQLADCFSNDIHKLDTSTMTWTLVCTKGNPARWRDFHSATMLGNHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPHTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPGSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDIRWELNAMTTNSNISRPIVSSHG", "length": 382 }, "evidence": [ { "id": "Q58CV6", "url": "https://omabrowser.org/oma/group/Q58CV6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VEM9-1", "protein_name": "Kelch domain-containing protein 3", "gene_name": "Klhdc3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVRPAVRGQAPVVPYMRYGHSTVLIDDTVFLWGGRNDTEGACNVLYAFDVNTHKWSTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQLADCFSNDIHKLDTSTMTWTLVCTKGNPARWRDFHSATMLGNHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPHTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPGSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYSLDQSCLPHDIRWELNAMTTNSNISRPIVSSHG", "length": 382 }, "evidence": [ { "id": "Q58CV6", "url": "https://omabrowser.org/oma/group/Q58CV6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BQ90-1", "protein_name": "Kelch domain-containing protein 3", "gene_name": "KLHDC3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDIRWELNAMTTNSNISRPIVSSHG", "length": 382 }, "evidence": [ { "id": "Q58CV6", "url": "https://omabrowser.org/oma/group/Q58CV6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9W3D5-1", "protein_name": "Kelch domain-containing protein 3", "gene_name": "Dmel\\CG12081", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLWTVHLDGGPQRVNHAAVGVGDFIYSFGGYCTGYDYRYNEPIDVHALNAHTMRWTLVPQQLDDAGVPLKYPLVPFQRYGHTVVAYKDRIYIWGGRNDENLCNTLYCFDPKTAQWSRPQVTGCLPGARDGHSACVIGNSMYIFGGFVDEINEFSSDVHSLNLDTMEWRYVQTFGVPPSYRDFHASVAYEQERMYIFGGRGDKHSPYHSQEETYCHEIVYLDMKTKVWHRPFTAGKVPVGRRSHSMFVYNKLIYVFGGYNGLLDQHFNDLYTFDPRTKLWNLIRANGKAPTARRRQCAIVMGTRMFLFGGTSPRSGSSSSPAAVSPTQETGGAAAAGGVVPPGVALIDYSDLHVLDFEPTLKTLATMVVLKHQLDISGLPRSFRSDLQMLTQPNSISRPINQAG", "length": 403 }, "evidence": [ { "id": "Q58CV6", "url": "https://omabrowser.org/oma/group/Q58CV6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q58CV6", "url": "https://www.uniprot.org/uniprotkb/Q58CV6" } ], "pmid": "" }, { "name": "90S preribosome", "id": "GO:0030686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030686", "evidence": [ { "database": "UniProtKB", "id": "Q58CV6", "url": "https://www.uniprot.org/uniprotkb/Q58CV6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58CV6", "url": "https://www.uniprot.org/uniprotkb/Q58CV6" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "Q58CV6", "url": "https://www.uniprot.org/uniprotkb/Q58CV6" } ], "pmid": "" }, { "name": "Cul2-RING ubiquitin ligase complex", "id": "GO:0031462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031462", "evidence": [ { "database": "UniProtKB", "id": "Q58CV6", "url": "https://www.uniprot.org/uniprotkb/Q58CV6" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q58CV6", "url": "https://www.uniprot.org/uniprotkb/Q58CV6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "Q58CV6", "url": "https://www.uniprot.org/uniprotkb/Q58CV6" } ], "pmid": "" }, { "name": "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "id": "GO:0000462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000462", "evidence": [ { "database": "UniProtKB", "id": "Q58CV6", "url": "https://www.uniprot.org/uniprotkb/Q58CV6" } ], "pmid": "" }, { "name": "ribosomal small subunit biogenesis", "id": "GO:0042274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042274", "evidence": [ { "database": "UniProtKB", "id": "Q58CV6", "url": "https://www.uniprot.org/uniprotkb/Q58CV6" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q58CV6", "url": "https://www.uniprot.org/uniprotkb/Q58CV6" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q58CV6", "url": "https://www.uniprot.org/uniprotkb/Q58CV6" } ], "pmid": "" }, { "name": "meiotic cell cycle", "id": "GO:0051321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051321", "evidence": [ { "database": "UniProtKB", "id": "Q58CV6", "url": "https://www.uniprot.org/uniprotkb/Q58CV6" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "id": "GO:0140627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140627", "evidence": [ { "database": "UniProtKB", "id": "Q58CV6", "url": "https://www.uniprot.org/uniprotkb/Q58CV6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "Q58CV6", "url": "https://www.uniprot.org/uniprotkb/Q58CV6" } ], "pmid": "" }, { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "Q58CV6", "url": "https://www.uniprot.org/uniprotkb/Q58CV6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 372, "end_pos": 374, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CV6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 382, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CV6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CV6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 372, "end_pos": 374 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17135", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17135", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": 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"Q5E973", "url": "https://www.uniprot.org/uniprotkb/Q5E973", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E973-1", "url": "https://www.uniprot.org/uniprotkb/Q5E973-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGREGKTAVVVGTITDDVRVQEVPKLKVCALRVSSRARSRILKAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYKN", "length": 188, "header": "sp|Q5E973-1|RL18_BOVIN Isoform 1 of Large ribosomal subunit protein eL18 OS=Bos taurus OX=9913 GN=RPL18 PE=2 SV=3 CANONICAL=Q5E973-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M9B3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E973/entry#A0A3Q1M9B3-1", "sequence": { "sequence": "MSSRRNTLKAFPAHRASAFSFRIWLRRRRHHGELALRRPGLDHPLPSTAAPGWGRSKGRQGFTGVQRRRLPRRGAVLEARRPGGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGREGKTAVVVGTITDDVRVQEVPKLKVCALRVSSRARSRILKAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYKN", "length": 270, "header": "tr|A0A3Q1M9B3-1|RL18_BOVIN Computationally mapped isoform of Large ribosomal subunit protein eL18 OS=Bos taurus OX=9913 GN=RPL18 PE=2 SV=2 CANONICAL=Q5E973-1" }, "locus": { "chromosome": "18", "start_pos": 55264012, "end_pos": 55260224, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068573.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068573.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065029.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065029.2" } ] } }, { "isoform_ac": "A0A452DIR2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E973/entry#A0A452DIR2-1", "sequence": { "sequence": "MRGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGREGKTAVVVGTITDDVRVQEVPKLKVCALRVSSRARSRILKAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYKN", "length": 189, "header": "tr|A0A452DIR2-1|RL18_BOVIN Computationally mapped isoform of Large ribosomal subunit protein eL18 OS=Bos taurus OX=9913 GN=RPL18 PE=2 SV=1 CANONICAL=Q5E973-1" }, "locus": { "chromosome": "18", "start_pos": 55262734, "end_pos": 55260224, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020452.4", "url": "https://www.ensembl.org/id/ENSBTAT00000020452.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020452.3", "url": "https://www.ensembl.org/id/ENSBTAP00000020452.3" } ] } }, { "isoform_ac": "A0AAA9TMQ9-1", "url": "https://www.uniprot.org/uniprotkb/Q5E973/entry#A0AAA9TMQ9-1", "sequence": { "sequence": "MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGREGKTAVVVGTITDDVRVQEVPKLKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYKN", "length": 133, "header": "tr|A0AAA9TMQ9-1|RL18_BOVIN Computationally mapped isoform of Large ribosomal subunit protein eL18 OS=Bos taurus OX=9913 GN=RPL18 PE=2 SV=1 CANONICAL=Q5E973-1" }, "locus": { "chromosome": "18", "start_pos": 55263921, "end_pos": 55260224, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115135.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115135.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099789.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099789.1" } ] } }, { "isoform_ac": "A0AAF7ALE0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E973/entry#A0AAF7ALE0-1", "sequence": { "sequence": "MLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGREGKTAVVVGTITDDVRVQEVPKLKVCALRVSSRARSRILKAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYKN", "length": 159, "header": "tr|A0AAF7ALE0-1|RL18_BOVIN Computationally mapped isoform of Large ribosomal subunit protein eL18 OS=Bos taurus OX=9913 GN=RPL18 PE=2 SV=1 CANONICAL=Q5E973-1" }, "locus": { "chromosome": "18", "start_pos": 55263921, "end_pos": 55260224, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070298.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070298.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071295.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071295.2" } ] } }, { "isoform_ac": "Q5E973-1", "url": "https://www.uniprot.org/uniprotkb/Q5E973/entry#Q5E973-1", "sequence": { "sequence": "MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGREGKTAVVVGTITDDVRVQEVPKLKVCALRVSSRARSRILKAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYKN", "length": 188, "header": "sp|Q5E973-1|RL18_BOVIN Isoform 1 of Large ribosomal subunit protein eL18 OS=Bos taurus OX=9913 GN=RPL18 PE=2 SV=3 CANONICAL=Q5E973-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 130, "end_pos": 130, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E973", "url": "https://www.uniprot.org/uniprotkb/Q5E973" } ], "site_lbl": "Ser130" }, { "start_pos": 158, "end_pos": 158, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E973", "url": "https://www.uniprot.org/uniprotkb/Q5E973" } ], "site_lbl": "Thr158" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E973", "url": "https://www.uniprot.org/uniprotkb/Q5E973" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:509163", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509163", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "P0CX49-1", "protein_name": "Large ribosomal subunit protein eL18A", "gene_name": "RPL18A", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MGIDHTSKQHKRSGHRTAPKSDNVYLKLLVKLYTFLARRTDAPFNKVVLKALFLSKINRPPVSVSRIARALKQEGAANKTVVVVGTVTDDARIFEFPKTTVAALRFTAGARAKIVKAGGECITLDQLAVRAPKGQNTLILRGPRNSREAVRHFGMGPHKGKAPRILSTGRKFERARGRRRSKGFKV", "length": 186 }, "evidence": [ { "id": "Q5E973", "url": "https://omabrowser.org/oma/group/Q5E973/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P0CX50-1", "protein_name": "Large ribosomal subunit protein eL18B", "gene_name": "RPL18B", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MGIDHTSKQHKRSGHRTAPKSDNVYLKLLVKLYTFLARRTDAPFNKVVLKALFLSKINRPPVSVSRIARALKQEGAANKTVVVVGTVTDDARIFEFPKTTVAALRFTAGARAKIVKAGGECITLDQLAVRAPKGQNTLILRGPRNSREAVRHFGMGPHKGKAPRILSTGRKFERARGRRRSKGFKV", "length": 186 }, "evidence": [ { "id": "Q5E973", "url": "https://omabrowser.org/oma/group/Q5E973/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P35980-1", "protein_name": "Large ribosomal subunit protein eL18", "gene_name": "Rpl18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGRENKTAVVVGTVTDDVRILEVPKLKVCALRVSSRARSRILKAGGKILTFDQLALESPKGRGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYKN", "length": 188 }, "evidence": [ { "id": "Q5E973", "url": "https://omabrowser.org/oma/group/Q5E973/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P42791-1", "protein_name": "Large ribosomal subunit protein eL18y", "gene_name": "RPL18B", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGIDLIAGGKSKKTKRTAPKSDDVYLKLTVKLYRFLVRRTNSKFNGVILKRLFMSKVNKAPLSLSRLVEFMTGKEDKIAVLVGTITDDLRVHEIPAMKVTALRFTERARARIEKAGGECLTFDQLALRAPLGQNTVLLRGPKNSREAVKHFGPAPGVPHSHSKPYVRAKGRKFEKARGKRKSRGFKV", "length": 187 }, "evidence": [ { "id": "Q5E973", "url": "https://omabrowser.org/oma/group/Q5E973/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q07020-1", "protein_name": 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], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q95342-1", "protein_name": "Large ribosomal subunit protein eL18", "gene_name": "RPL18", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVFPSPLQGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGREGKTAVVVGTITDDVRVQEVPKLKVCALRVSSRARSRILKAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYKN", "length": 195 }, "evidence": [ { "id": "Q5E973", "url": "https://omabrowser.org/oma/group/Q5E973/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9VS34-1", "protein_name": "Large ribosomal subunit protein eL18", "gene_name": "RpL18", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": 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"id": "NP_001030495", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030495" } ] }, { "name": "rho guanine nucleotide exchange factor 9", "type": "synonym", "evidence": [ { "id": "NP_001030495", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030495" } ] } ], "function": [ { "annotation": "Acts as a guanine nucleotide exchange factor (GEF) for CDC42. 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"https://www.genome.jp/dbget-bin/www_bget?bta:537718", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DJC2", "url": "https://www.orthodb.org/?gene=A0A452DJC2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q58DL7", "url": "https://www.orthodb.org/?gene=Q58DL7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47544", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47544", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47544:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47544:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00621", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00621", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22697", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22697", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030495", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLU7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLU7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLU7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M140", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M140", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M140-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M140-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MA22", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MA22-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA22-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MI85", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MI85-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI85-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJC2", "url": "https://www.uniprot.org/uniprotkb/A0A452DJC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJC2-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJC2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3R9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3R9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3R9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NL07", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NL07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NL07-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NL07-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P3K4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3K4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P3K4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3K4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DL7", "url": "https://www.uniprot.org/uniprotkb/Q58DL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DL7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DL7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELDQVGWRRSRKLCTDNLDQGSKTLETCKNIGGYFKPQGPGTEHINELITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDGVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQKRQAAMTVRKVSKQKGVNSARSVPPSYPPPQDPLNQGQYLVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK", "length": 561, "header": "sp|Q58DL7-1|ARHG9_BOVIN Isoform 1 of Rho guanine nucleotide exchange factor 9 OS=Bos taurus OX=9913 GN=ARHGEF9 PE=2 SV=1 CANONICAL=Q58DL7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LLU7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DL7/entry#A0A3Q1LLU7-1", "sequence": { "sequence": "MEKLEEKPNEMEKPEACKGAGASIQGGQPQDSDLDMRTAGADRKASKSSTGVLGTQTFFPPAEPSPRTAPLKILLEKCHSLSISQSIPMELDQVGWRRSRKLCTDNLDQGSKTLETCKNIGGYFKPQGPGTEHINECLWFGNAEHHVPHSMLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDGVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQKRQAAMTVRKVSKQKGVNSARSVPPSYPPPQDPLNQGQYLVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK", "length": 664, "header": "tr|A0A3Q1LLU7-1|ARHG9_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 9 OS=Bos taurus OX=9913 GN=ARHGEF9 PE=2 SV=3 CANONICAL=Q58DL7-1" }, "locus": { "chromosome": "X", "start_pos": 96674070, "end_pos": 96335250, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084281.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084281.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057765.3", "url": "https://www.ensembl.org/id/ENSBTAP00000057765.3" } ] } }, { "isoform_ac": "A0A3Q1M140-1", "url": "https://www.uniprot.org/uniprotkb/Q58DL7/entry#A0A3Q1M140-1", "sequence": { "sequence": "MDKGMAESGTECLWFGNAEHHVPHSMLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDGVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQKRQAAMTVRKVSKQKGVNSARSVPPSYPPPQDPLNQGQYLVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK", "length": 539, "header": "tr|A0A3Q1M140-1|ARHG9_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 9 OS=Bos taurus OX=9913 GN=ARHGEF9 PE=2 SV=3 CANONICAL=Q58DL7-1" }, "locus": { "chromosome": "X", "start_pos": 96674070, "end_pos": 96506744, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075602.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075602.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063684.3", "url": "https://www.ensembl.org/id/ENSBTAP00000063684.3" } ] } }, { "isoform_ac": "A0A3Q1MA22-1", "url": "https://www.uniprot.org/uniprotkb/Q58DL7/entry#A0A3Q1MA22-1", "sequence": { "sequence": "METLSSCRTTFLSDLVPNGYLVQVFPGHPEVEGLAREVGLEKSEQCDQGDLSSREENGQNKKKIKVNKIWDFMSRRKEASSQAKRPQSMILLGDSSRPSELKPKVTLKDRMKAFKRLKPSTGASKNTTLRSSKVQEPQEVSHIYHMRKAQEASKPFRYSYSGHNEGLEPFLADVQRLMPKNQKVLAFDDFGIHVEEDHWEKESSEQSGRGRWARSYLKHTFPGDCEAPCRSAGDSRIQDPESAIKASTLEGNVERGYEESLRHLRRDKAVPFGSVVKFFSNVAEMARKWRALSREELQMSHRRDKTYFISGGSEALIIEGAASQASFPLSQTPEVMVWGNVIERCQHCHQKASQASCTFEMSIEGKKTLGQALEDPCTAAALVSTSTSPVFELQDDPTPQTGCSCHYGHVFTMESSSEELDEDIETVVNILKEDDSAGQSPEPGTCAKLTTKAVMEKLEEKPNEMEKPEACKGAGASIQGGQPQDSDLDMRTAGADRKASKSSTGVLGTQTFFPPAEPSPRTAPLKILLEKCHSLSISQSIPMELDQVGWRRSRKLCTDNLDQGSKTLETCKNIGGYFKPQGPGTEHINELITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDGVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQKRQAAMTVRKVSKQKGVNSARSVPPSYPPPQDPLNQGQYLVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLLPPLT", "length": 1103, "header": "tr|A0A3Q1MA22-1|ARHG9_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 9 OS=Bos taurus OX=9913 GN=ARHGEF9 PE=2 SV=1 CANONICAL=Q58DL7-1" }, "locus": { "chromosome": "X", "start_pos": 96675074, "end_pos": 96333888, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069238.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069238.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070842.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070842.1" } ] } }, { "isoform_ac": "A0A3Q1MI85-1", "url": "https://www.uniprot.org/uniprotkb/Q58DL7/entry#A0A3Q1MI85-1", "sequence": { "sequence": "MQWIRGGSGMLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDGVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQKRQAAMTVRKVSKQKGVNSARSVPPSYPPPQDPLNQGQYLVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK", "length": 523, "header": "tr|A0A3Q1MI85-1|ARHG9_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 9 OS=Bos taurus OX=9913 GN=ARHGEF9 PE=2 SV=3 CANONICAL=Q58DL7-1" }, "locus": { "chromosome": "X", "start_pos": 96674070, "end_pos": 96455516, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067839.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067839.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070975.3", "url": "https://www.ensembl.org/id/ENSBTAP00000070975.3" } ] } }, { "isoform_ac": "A0A452DJC2-1", "url": "https://www.uniprot.org/uniprotkb/Q58DL7/entry#A0A452DJC2-1", "sequence": { "sequence": "MTILRVWSLLKVKGRLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDGVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQKRQAAMTVRKVSKQKGVNSARSVPPSYPPPQDPLNQGQYLVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK", "length": 528, "header": "tr|A0A452DJC2-1|ARHG9_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 9 OS=Bos taurus OX=9913 GN=ARHGEF9 PE=2 SV=3 CANONICAL=Q58DL7-1" }, "locus": { "chromosome": "X", "start_pos": 96674070, "end_pos": 96468875, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016923.8", "url": "https://www.ensembl.org/id/ENSBTAT00000016923.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016923.8", "url": "https://www.ensembl.org/id/ENSBTAP00000016923.8" } ] } }, { "isoform_ac": "A0AAA9SG21-1", "url": "https://www.uniprot.org/uniprotkb/Q58DL7/entry#A0AAA9SG21-1", "sequence": { "sequence": "MLLNCGVGEDSCESHGLQGDQSWVFFGRNDAKAETPVLWPPHLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDGVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQKRQAAMTVRKVSKQKGVNSARSVPPSYPPPQDPLNQGQYLVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK", "length": 555, "header": "tr|A0AAA9SG21-1|ARHG9_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 9 OS=Bos taurus OX=9913 GN=ARHGEF9 PE=2 SV=2 CANONICAL=Q58DL7-1" }, "locus": { "chromosome": "X", "start_pos": 96674070, "end_pos": 96514113, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126108.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126108.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081414.2", "url": "https://www.ensembl.org/id/ENSBTAP00000081414.2" } ] } }, { "isoform_ac": "A0AAA9T3R9-1", "url": "https://www.uniprot.org/uniprotkb/Q58DL7/entry#A0AAA9T3R9-1", "sequence": { "sequence": "MLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDGVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQKRQAAMTVRKVSKQKGVNSARSVPPSYPPPQDPLNQGQYLVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK", "length": 514, "header": "tr|A0AAA9T3R9-1|ARHG9_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 9 OS=Bos taurus OX=9913 GN=ARHGEF9 PE=2 SV=2 CANONICAL=Q58DL7-1" }, "locus": { "chromosome": "X", "start_pos": 96674070, "end_pos": 96510505, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133571.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133571.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092425.2", "url": "https://www.ensembl.org/id/ENSBTAP00000092425.2" } ] } }, { "isoform_ac": "A0ABI0NL07-1", "url": "https://www.uniprot.org/uniprotkb/Q58DL7/entry#A0ABI0NL07-1", "sequence": { "sequence": "MTLLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDGVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQKRQAAMTVRKVSKQKGVNSARSVPPSYPPPQDPLNQGQYLVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK", "length": 516, "header": "tr|A0ABI0NL07-1|A0ABI0NL07_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 9 OS=Bos taurus OX=9913 GN=ARHGEF9 PE=4 SV=1 CANONICAL=Q58DL7-1" }, "locus": { "chromosome": "X", "start_pos": 96674070, "end_pos": 96484644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000149793.1", "url": "https://www.ensembl.org/id/ENSBTAT00000149793.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105573.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105573.1" } ] } }, { "isoform_ac": "A0ABI0P3K4-1", "url": "https://www.uniprot.org/uniprotkb/Q58DL7/entry#A0ABI0P3K4-1", "sequence": { "sequence": "MESSSEELDEDIETVVNILKEDDSAGQSPEPGTCAKLTTKAVMEKLEEKPNEMEKPEACKGAGASIQGGQPQDSDLDMRTAGADRKASKSSTGVLGTQLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDGVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQKRQAAMTVRKVSKQKGVNSARSVPPSYPPPQDPLNQGQYLVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK", "length": 611, "header": "tr|A0ABI0P3K4-1|A0ABI0P3K4_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 9 OS=Bos taurus OX=9913 GN=ARHGEF9 PE=4 SV=1 CANONICAL=Q58DL7-1" }, "locus": { "chromosome": "X", "start_pos": 96674070, "end_pos": 96335124, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000150723.1", "url": "https://www.ensembl.org/id/ENSBTAT00000150723.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106202.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106202.1" } ] } }, { "isoform_ac": "Q58DL7-1", "url": "https://www.uniprot.org/uniprotkb/Q58DL7/entry#Q58DL7-1", "sequence": { "sequence": "MELDQVGWRRSRKLCTDNLDQGSKTLETCKNIGGYFKPQGPGTEHINELITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDGVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGFEISENQKRQAAMTVRKVSKQKGVNSARSVPPSYPPPQDPLNQGQYLVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK", "length": 561, "header": "sp|Q58DL7-1|ARHG9_BOVIN Isoform 1 of Rho guanine nucleotide exchange factor 9 OS=Bos taurus OX=9913 GN=ARHGEF9 PE=2 SV=1 CANONICAL=Q58DL7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 547, "end_pos": 547, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DL7", "url": "https://www.uniprot.org/uniprotkb/Q58DL7" } ], "site_lbl": "Ser547" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DL7", "url": "https://www.uniprot.org/uniprotkb/Q58DL7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:537718", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537718", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "GABA-ergic synapse", "id": "GO:0098982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098982", "evidence": [ { "database": "UniProtKB", "id": "Q58DL7", "url": "https://www.uniprot.org/uniprotkb/Q58DL7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q58DL7", "url": "https://www.uniprot.org/uniprotkb/Q58DL7" } ], "pmid": "" }, { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "Q58DL7", "url": "https://www.uniprot.org/uniprotkb/Q58DL7" } ], "pmid": "" }, { "name": "postsynaptic specialization", "id": "GO:0099572", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099572", "evidence": [ { "database": "UniProtKB", "id": "Q58DL7", "url": "https://www.uniprot.org/uniprotkb/Q58DL7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58DL7", "url": "https://www.uniprot.org/uniprotkb/Q58DL7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "Q58DL7", "url": "https://www.uniprot.org/uniprotkb/Q58DL7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of postsynaptic specialization assembly", "id": "GO:0099150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099150", "evidence": [ { "database": "UniProtKB", "id": "Q58DL7", "url": "https://www.uniprot.org/uniprotkb/Q58DL7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 324, "end_pos": 326, "annotation": "n_glycosylation_sequon" }, { "start_pos": 430, "end_pos": 432, "annotation": "n_glycosylation_sequon" }, { "start_pos": 552, "end_pos": 554, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DL7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 561, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DL7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DL7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58DL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DL7" }, { "id": "PRU00062", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00062" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DH", "eco_id": "ECO_0000255", "start_pos": 148, "end_pos": 332, "start_aa": "Met", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58DL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DL7" }, { "id": "PRU00145", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00145" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000255", "start_pos": 363, "end_pos": 470, "start_aa": "Glu", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58DL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DL7" }, { "id": "PRU00192", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00192" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000255", "start_pos": 53, "end_pos": 112, "start_aa": "Asp", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 547 ], "sequon_annotation_sites": [ { "start_pos": 324, "end_pos": 326 }, { "start_pos": 430, "end_pos": 432 }, { "start_pos": 552, "end_pos": 554 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9E4-1", "uniprot_ac": "Q5E9E4", "uniprot_id": "SSRB_BOVIN", "mass": { "chemical_mass": 20123.0, "monoisotopic_mass": 20123.0 }, "refseq": { "ac": "NP_001015533", "name": "translocon-associated protein subunit beta precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015533" }, "gene_names": [ { "name": "SSR2", "type": "recommended", "evidence": [ { "id": "Q5E9E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E4" } ] }, { "name": "SSR2", "type": "synonym", "evidence": [ { "id": "NP_001015533", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015533" } ] } ], "protein_names": [ { "name": "Translocon-associated protein subunit beta", "type": "recommended", "evidence": [ { "id": "Q5E9E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E4/entry#names_and_taxonomy" } ] }, { "name": "SSR-beta", "type": "synonym", "evidence": [ { "id": "NP_001015533", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015533" }, { "id": "Q5E9E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E4/entry#names_and_taxonomy" } ] }, { "name": "Signal sequence receptor subunit beta", "type": "synonym", "evidence": [ { "id": "Q5E9E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E4/entry#names_and_taxonomy" } ] }, { "name": "TRAP-beta", "type": "synonym", "evidence": [ { "id": "NP_001015533", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015533" }, { "id": "Q5E9E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E4/entry#names_and_taxonomy" } ] }, { "name": "signal sequence receptor subunit beta", "type": "synonym", "evidence": [ { "id": "NP_001015533", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015533" } ] }, { "name": "signal sequence receptor, beta (translocon-associated protein beta)", "type": "synonym", "evidence": [ { "id": "NP_001015533", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015533" } ] }, { "name": "translocon-associated protein subunit beta precursor", "type": "synonym", "evidence": [ { "id": "NP_001015533", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015533" } ] }, { "name": "translocon-associated protein subunit beta", "type": "synonym", "evidence": [ { "id": "NP_001015533", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015533" } ] } ], "function": [ { "annotation": "TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MDG8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDG8#function" }, { "database": "UniProtKB", "id": "PIRNR016400", "url": "https://www.uniprot.org/uniprotkb/PIRNR016400#function" }, { "database": "UniProtKB", "id": "ARBA00002838", "url": "https://www.uniprot.org/uniprotkb/ARBA00002838#function" }, { "database": "UniProtKB", "id": "Q5E9E4", "url": "https://www.uniprot.org/uniprotkb/Q5E9E4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9E4", "url": "https://www.uniprot.org/uniprotkb/Q5E9E4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SSR2", "url": "https://www.uniprot.org/uniprotkb/Q5E9E4", "locus": { "chromosome": "3", "start_pos": 14760783, "end_pos": 14754151, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001212", "url": "https://www.ensembl.org/id/ENSBTAG00000001212" } ] } } ], "crossref": [ { "id": "Q5E9E4", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9E4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001212", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001212", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506530", "url": "https://www.ncbi.nlm.nih.gov/gene/506530", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008856", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008856", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506530", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506530", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ILWHSSK", "url": "https://omabrowser.org/oma/group/ILWHSSK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MDG8", "url": "https://www.orthodb.org/?gene=A0A3Q1MDG8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5E9E4", "url": "https://www.orthodb.org/?gene=Q5E9E4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12861", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12861", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12861:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12861:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05753", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05753", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015533", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDG8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDG8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDG8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZHA6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZHA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZHA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9E4", "url": "https://www.uniprot.org/uniprotkb/Q5E9E4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9E4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9E4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLLAFAVLALFAVTQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELSDDSFPPEDFGIVSGMLNVKWDRIAPASNVSHTVVLRPLKAGYFNFTSATVTYLAQEDGPVVIGFTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIGVPLLLWYSSKRKYDTPKTKKN", "length": 183, "header": "sp|Q5E9E4-1|SSRB_BOVIN Isoform 1 of Translocon-associated protein subunit beta OS=Bos taurus OX=9913 GN=SSR2 PE=2 SV=1 CANONICAL=Q5E9E4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MDG8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9E4/entry#A0A3Q1MDG8-1", "sequence": { "sequence": "MCTMRLLAFAVLALFAVTQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELSDDSFPPEDFGIVSGMLNVKWDRIAPASNVSHTVVLRPLKAGYFNFTSATVTYLAQEDGPVVIGFTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIGVPLLLWYSSKRKYDTPKTKKN", "length": 186, "header": "tr|A0A3Q1MDG8-1|SSRB_BOVIN Computationally mapped isoform of Translocon-associated protein subunit beta OS=Bos taurus OX=9913 GN=SSR2 PE=2 SV=1 CANONICAL=Q5E9E4-1" }, "locus": { "chromosome": "3", "start_pos": 14760314, "end_pos": 14754189, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073018.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073018.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066874.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066874.1" } ] } }, { "isoform_ac": "A0AAF6ZHA6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9E4/entry#A0AAF6ZHA6-1", "sequence": { "sequence": "MRLLAFAVLALFAVTQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELSDDSFPPEDFGIVSGMLNVKWDRIAPWTGQPSGS", "length": 93, "header": "tr|A0AAF6ZHA6-1|SSRB_BOVIN Computationally mapped isoform of Translocon-associated protein subunit beta OS=Bos taurus OX=9913 GN=SSR2 PE=2 SV=1 CANONICAL=Q5E9E4-1" }, "locus": { "chromosome": "3", "start_pos": 14760231, "end_pos": 14754780, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047947.5", "url": "https://www.ensembl.org/id/ENSBTAT00000047947.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045096.4", "url": "https://www.ensembl.org/id/ENSBTAP00000045096.4" } ] } }, { "isoform_ac": "Q5E9E4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9E4/entry#Q5E9E4-1", "sequence": { "sequence": "MRLLAFAVLALFAVTQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELSDDSFPPEDFGIVSGMLNVKWDRIAPASNVSHTVVLRPLKAGYFNFTSATVTYLAQEDGPVVIGFTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIGVPLLLWYSSKRKYDTPKTKKN", "length": 183, "header": "sp|Q5E9E4-1|SSRB_BOVIN Isoform 1 of Translocon-associated protein subunit beta OS=Bos taurus OX=9913 GN=SSR2 PE=2 SV=1 CANONICAL=Q5E9E4-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 88, "start_aa": "Asn", "end_pos": 88, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn88", "evidence": [ { "id": "Q5E9E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E4#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E4", "url": "https://www.uniprot.org/uniprotkb/Q5E9E4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:506530", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506530", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1W122-1", "protein_name": "Translocon-associated protein subunit beta", "gene_name": "SSR2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRLLAFVVLTLFAVTQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELSDDSFPPEDFGIVSGMLNVKWDRIAPASNVSHTVVLRPLKAGYFNFTSATITYLAQEDGPVVIGFTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIGIPLLLWYSSKRKYDTPKTKKN", "length": 183 }, "evidence": [ { "id": "Q5E9E4", "url": "https://omabrowser.org/oma/group/Q5E9E4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F7F8A8-1", "protein_name": "Translocon-associated protein subunit beta", "gene_name": "Ssr2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRSLVVVVLALLAVSQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELSDDSFPPEDFGIVSDLRHHFFFLNPWASASNVSHTVVLRPLKAGYFNFTSATITYLAQEDGPVVIGSTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIGIPLLLWYSSKRKYDTPKPKKN", "length": 185 }, "evidence": [ { "id": "Q5E9E4", "url": "https://omabrowser.org/oma/group/Q5E9E4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F8W477-1", "protein_name": "Translocon-associated protein subunit beta", "gene_name": "ssr2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKMRILCIFALVAVVGLVAGEEGARLLASKSLLNRYAVEGRDLTLQYSIYNVGTSAALEVELSDDSFPPEDFGIVSGMLNVKWDRIAPASNVSHTVVLRPLKAGYFNFTSASVSYLAQEGGQVVVGYTSAPGQGGILAQREFDRRFSPHYLDWAAFGVMTLPSIGIPLLLWYSSKRKYDSPKSKKN", "length": 186 }, "evidence": [ { "id": "Q5E9E4", "url": "https://omabrowser.org/oma/group/Q5E9E4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3HGA2-1", "protein_name": "Translocon-associated protein subunit beta", "gene_name": "Ssr2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRPLAFVVLALLAVSQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELSDDSFPPEDFGIVSGMLNVKWDRIAPASNVSHTVVLRPLKAGYFNFTSATITYLAQEDGPVVIGSTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIGIPLLLWYSSKRKYDTPKPKKN", "length": 183 }, "evidence": [ { "id": "Q5E9E4", "url": "https://omabrowser.org/oma/group/Q5E9E4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P43308-1", "protein_name": "Translocon-associated protein subunit beta", "gene_name": "SSR2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRLLSFVVLALFAVTQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELSDDSFPPEDFGIVSGMLNVKWDRIAPASNVSHTVVLRPLKAGYFNFTSATITYLAQEDGPVVIGSTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIGIPLLLWYSSKRKYDTPKTKKN", "length": 183 }, "evidence": [ { "id": "Q5E9E4", "url": "https://omabrowser.org/oma/group/Q5E9E4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CPW5-1", "protein_name": "Translocon-associated protein subunit beta", "gene_name": "Ssr2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRLLAVVVLALLAVSQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELSDDSFPPEDFGIVSGMLNVKWDRIAPASNVSHTVVLRPLKAGYFNFTSATITYLAQEDGPVVIGSTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIGIPLLLWYSSKRKYDTPKPKKN", "length": 183 }, "evidence": [ { "id": "Q5E9E4", "url": "https://omabrowser.org/oma/group/Q5E9E4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VUZ0-1", "protein_name": "Translocon-associated protein subunit beta", "gene_name": "SsRbeta", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFKHLLTLFALCAVFSTCLSEDETRARLLVSKQILNKYLVEKSDLLVRYTIFNVGSGAATKVRLVDSGFHPEAFDVVGGQPTAVVDRIAPQTNFTHVLVVRPKAFGYFNFTAAEVSYKAVEESETLQLAVSSEPGEGGIVNLNEYNKRFSSHFFDWVAFAVMTLPSLAIPLALWHQSKSKYERSGKNKKH", "length": 190 }, "evidence": [ { "id": "Q5E9E4", "url": "https://omabrowser.org/oma/group/Q5E9E4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E4", "url": "https://www.uniprot.org/uniprotkb/Q5E9E4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9E4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 183, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9E4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9E4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 88 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 104, "end_pos": 106 }, { "start_pos": 88, "end_pos": 90 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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}, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA75-1", "uniprot_ac": "Q5EA75", "uniprot_id": "PCY2_BOVIN", "mass": { "chemical_mass": 44158.0, "monoisotopic_mass": 44158.0 }, "refseq": { "ac": "NP_001030261", "name": "ethanolamine-phosphate cytidylyltransferase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030261" }, "gene_names": [ { "name": "PCYT2", "type": "recommended", "evidence": [ { "id": "Q5EA75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA75" } ] }, { "name": "PCYT2", "type": "synonym", "evidence": [ { "id": "NP_001030261", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030261" } ] } ], "protein_names": [ { "name": "Ethanolamine-phosphate cytidylyltransferase", "type": "recommended", "evidence": [ { "id": "Q5EA75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA75/entry#names_and_taxonomy" } ] }, { "name": "2.7.7.14", "type": "synonym", "evidence": [ { "id": "Q5EA75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA75/entry#names_and_taxonomy" } ] }, { "name": "CTP:phosphoethanolamine cytidylyltransferase", "type": "synonym", "evidence": [ { "id": "NP_001030261", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030261" }, { "id": "Q5EA75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA75/entry#names_and_taxonomy" } ] }, { "name": "Phosphorylethanolamine transferase", "type": "synonym", "evidence": [ { "id": "Q5EA75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA75/entry#names_and_taxonomy" } ] }, { "name": "ethanolamine-phosphate cytidylyltransferase", "type": "synonym", "evidence": [ { "id": "NP_001030261", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030261" } ] }, { "name": "phosphorylethanolamine transferase", "type": "synonym", "evidence": [ { "id": "NP_001030261", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030261" } ] } ], "function": [ { "annotation": "Ethanolamine-phosphate cytidylyltransferase that catalyzes the second step in the synthesis of phosphatidylethanolamine (PE) from ethanolamine via the CDP-ethanolamine pathway. Phosphatidylethanolamine is a dominant inner-leaflet phospholipid in cell membranes, where it plays a role in membrane function by structurally stabilizing membrane-anchored proteins, and participates in important cellular processes such as cell division, cell fusion, blood coagulation, and apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "Q5EA75", "url": "https://www.uniprot.org/uniprotkb/Q5EA75#function" }, { "database": "UniProtKB", "id": "Q99447", "url": "https://www.uniprot.org/uniprotkb/Q99447#function" }, { "database": "UniProtKB", "id": "A0A3Q1MLB5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB5#function" }, { "database": "UniProtKB", "id": "ARBA00054234", "url": "https://www.uniprot.org/uniprotkb/ARBA00054234#function" }, { "database": "UniProtKB", "id": "A0A452DHY7", "url": "https://www.uniprot.org/uniprotkb/A0A452DHY7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA75", "url": "https://www.uniprot.org/uniprotkb/Q5EA75" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCYT2", "url": "https://www.uniprot.org/uniprotkb/Q5EA75", "locus": { "chromosome": "19", "start_pos": 50990081, "end_pos": 50982926, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001868", "url": "https://www.ensembl.org/id/ENSBTAG00000001868" } ] } } ], "crossref": [ { "id": "Q5EA75", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA75", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001868", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001868", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02173", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02173", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": 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"categories": [ "Enzyme and Pathway" ] }, { "id": "QCKYINA", "url": "https://omabrowser.org/oma/group/QCKYINA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MLB5", "url": "https://www.orthodb.org/?gene=A0A3Q1MLB5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DHY7", "url": "https://www.orthodb.org/?gene=A0A452DHY7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5EA75", "url": "https://www.orthodb.org/?gene=Q5EA75", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45780", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45780", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45780:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45780:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01467", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01467", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1483213", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483213", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030261", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "24592", "url": "https://www.rhea-db.org/rhea/24592", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MLB5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLB5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DHY7", "url": "https://www.uniprot.org/uniprotkb/A0A452DHY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DHY7-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DHY7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RRE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RRE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA75", "url": "https://www.uniprot.org/uniprotkb/Q5EA75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA75-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA75-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIRNGHGEAGGAKRPGPRARRAVRVWCDGCYDMVHYGHSNQLRQARAMGDHLIVGVHTDEEIAKHKGPPVFTQEERYKMVQAIKWVDEVVPAAPYVTTLETLDKYNCDFCVHGNDITLTVDGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRMLLVTKAHHSSQEMSSEYREYADSFGKCPGGRNPWTGVSQFLQTSQKIIQFASGKEPQPGETVIYVAGAFDLFHIGHVDFLEKVYGLAERPYVIAGLHFDQEVNHYKGKNYPIMNLHERTLSVLACRYVSEVVIGAPYSVTAELLDHFKVDLVCHGKTEVVPDKDGSDPYEEPKRRGIFCQVDSGNDLTTDLIVQRIIKNRLEYEARNQKKEAKELAFQEAMRRQEAQPEREIDCDF", "length": 389, "header": "sp|Q5EA75-1|PCY2_BOVIN Isoform 1 of Ethanolamine-phosphate cytidylyltransferase OS=Bos taurus OX=9913 GN=PCYT2 PE=2 SV=1 CANONICAL=Q5EA75-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MLB5-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA75/entry#A0A3Q1MLB5-1", "sequence": { "sequence": "MIRNGHGEAGGAKRPGPRARRAVRVWCDGCYDMVHYGHSNQLRQARAMGDHLIVGVHTDEEIAKHKGPPVFTQEERYKMVQAIKWVDEVVPAAPYVTTLETLDKYNCDFCVHGNDITLTVDGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRMLLVTKAHHSSQEMSSEYREYADSFGKPPHPTPAGETLCSEGSSQCPGGRNPWTGVSQFLQTSQKIIQFASGKEPQPGETVIYVAGAFDLFHIGHVDFLEKVYGLAERPYVIAGLHFDQEVNHYKGKNYPIMNLHERTLSVLACRYVSEVVIGAPYSVTAELLDHFKVDLVCHGKTEVVPDKDGSDPYEEPKRRGIFCQVDSGNDLTTDLIVQRIIKNRLEYEARNQKKEAKELAFQEAMRRQETQPEREIDCDF", "length": 407, "header": "tr|A0A3Q1MLB5-1|PCY2_BOVIN Computationally mapped isoform of Ethanolamine-phosphate cytidylyltransferase OS=Bos taurus OX=9913 GN=PCYT2 PE=2 SV=1 CANONICAL=Q5EA75-1" }, "locus": { "chromosome": "19", "start_pos": 50989450, "end_pos": 50982961, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070509.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070509.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070069.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070069.1" } ] } }, { "isoform_ac": "A0A452DHY7-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA75/entry#A0A452DHY7-1", "sequence": { "sequence": "MIRNGHGEAGGAKRPGPRARRAVRVWCDGCYDMVHYGHSNQLRQARAMGDHLIVGVHTDEEIAKHKGPPVFTQEERYKMVQAIKWVDEVVPAAPYVTTLETLDKYNCDFCVHGNDITLTVDGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRMLLVTKAHHSSQEMSSEYREYADSFGKCPGGRNPWTGVSQFLQTSQKIIQFASGKEPQPGETVIYVAGAFDLFHIGHVDFLEKVYGLAERPYVIAGLHFDQEVNHYKGKNYPIMNLHERTLSVLACRYVSEVVIGAPYSVTAELLDHFKVDLVCHGKTEVVPDKDGSDPYEEPKRRGIFCQVDSGNDLTTDLIVQRIIKNRLEYEARNQKKEAKELAFQEAMRRQETQPEREIDCDF", "length": 389, "header": "tr|A0A452DHY7-1|PCY2_BOVIN Computationally mapped isoform of Ethanolamine-phosphate cytidylyltransferase OS=Bos taurus OX=9913 GN=PCYT2 PE=2 SV=1 CANONICAL=Q5EA75-1" }, "locus": { "chromosome": "19", "start_pos": 50989450, "end_pos": 50982961, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002434.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002434.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002434.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002434.5" } ] } }, { "isoform_ac": "A0AAA9RRE0-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA75/entry#A0AAA9RRE0-1", "sequence": { "sequence": "MIRNGHGEAGGAKRPGPRARRAVRVWCDGCYDMVHYGHSNQLRQARAMGDHLIVGVHTDEEIAKHKGPPVFTQEERYKMVQAIKWVDEVVPAAPYVTTLETLDKYNCDFCVHGNDITLTVDGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRMLLVTKAHHSSQEMSSEYREYADSFGKCPGGRNPWTGVSQFLQTSQKIIQFASGKEPQPGETVIYVAGAFDLFHIGHVDFLEKVYGLAERPYVIAGLHFDQEVNHYKGKNYPIMNLHERTLSVLACRYVSEVVIGAPYSVTAELLDHFKEPKRRGIFCQVDSGNDLTTDLIVQRIIKNRLEYEARNQKKEAKELAFQEAMRRQETQPEREIDCDF", "length": 367, "header": "tr|A0AAA9RRE0-1|PCY2_BOVIN Computationally mapped isoform of Ethanolamine-phosphate cytidylyltransferase OS=Bos taurus OX=9913 GN=PCYT2 PE=2 SV=1 CANONICAL=Q5EA75-1" }, "locus": { "chromosome": "19", "start_pos": 50989450, "end_pos": 50982961, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129615.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129615.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074653.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074653.1" } ] } }, { "isoform_ac": "Q5EA75-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA75/entry#Q5EA75-1", "sequence": { "sequence": "MIRNGHGEAGGAKRPGPRARRAVRVWCDGCYDMVHYGHSNQLRQARAMGDHLIVGVHTDEEIAKHKGPPVFTQEERYKMVQAIKWVDEVVPAAPYVTTLETLDKYNCDFCVHGNDITLTVDGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRMLLVTKAHHSSQEMSSEYREYADSFGKCPGGRNPWTGVSQFLQTSQKIIQFASGKEPQPGETVIYVAGAFDLFHIGHVDFLEKVYGLAERPYVIAGLHFDQEVNHYKGKNYPIMNLHERTLSVLACRYVSEVVIGAPYSVTAELLDHFKVDLVCHGKTEVVPDKDGSDPYEEPKRRGIFCQVDSGNDLTTDLIVQRIIKNRLEYEARNQKKEAKELAFQEAMRRQEAQPEREIDCDF", "length": 389, "header": "sp|Q5EA75-1|PCY2_BOVIN Isoform 1 of Ethanolamine-phosphate cytidylyltransferase OS=Bos taurus OX=9913 GN=PCYT2 PE=2 SV=1 CANONICAL=Q5EA75-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 341, "end_pos": 341, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA75", "url": "https://www.uniprot.org/uniprotkb/Q5EA75" } ], "site_lbl": "Thr341" }, { "start_pos": 342, "end_pos": 342, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA75", "url": "https://www.uniprot.org/uniprotkb/Q5EA75" } ], "site_lbl": "Thr342" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA75", "url": "https://www.uniprot.org/uniprotkb/Q5EA75" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:510274", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510274", "resource": "KEGG Pathway" }, { "id": "R-BTA-1483213", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483213", "resource": "Reactome", "description": "Synthesis of PE" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480SUV6-1", "protein_name": "Ethanolamine-phosphate cytidylyltransferase", "gene_name": "PCYT2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MIRNGHETAGGAERPGPGGRRPVRVWCDGCYDMVHYGHSNQLRQARAMGDHLIVGVHTDEEISKHKGPPVFTQEERYRMVQAIKWVDEVVPAAPYVTTLETLDKYGCDFCVHGNDITLTVDGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRMLLVTKAHHSSQEMPSEYREYADSFGKGPGGRNPWTGVSQFLQTSQKIIQFASGKEPQPGETVVYVAGAFDLFHIGHVDFLEKVHGLAERPYVIAGLHFDQEVNRYKGKNYPIMNLHERTLSVLACRYVSEVVIGAPYSVTAELLDHFKVDLVCHGKTEIVADRDGSDPYEEPKRRGIFCQISSGNDLTTDLIVQRIIKNRLEYEARNQKKEAKELAFLEAMRQQEVRPEGESDCDF", "length": 389 }, "evidence": [ { "id": "Q5EA75", "url": "https://omabrowser.org/oma/group/Q5EA75/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O88637-1", "protein_name": "Ethanolamine-phosphate cytidylyltransferase", "gene_name": "Pcyt2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIRNGHGAGGAAGLKGPGGQRTVRVWCDGCYDMVHYGHSNQLRQARAMGDYLIVGVHTDEEIAKHKGPPVFTQEERYKMVQAIKWVDEVVPAAPYVTTLETLDKHNCDFCVHGNDITLTVDGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRMLLVTKAHHSSQEMSSEYREYADSFGKPPHPTPAGDTLSSEVSSQCPGGQSPWTGVSQFLQTSQKIIQFASGKEPQPGETVIYVAGAFDLFHIGHVDFLQEVHKLAKRPYVIAGLHFDQEVNRYKGKNYPIMNLHERTLSVLACRYVSEVVIGAPYSVTAELLNHFKVDLVCHGKTEIVPDRDGSDPYEEPKRRGIFCQIDSGSDLTTDLIVQRIIKNRLEYEARNQKKEAKELAFLEALRQQEAQPRGETD", "length": 404 }, "evidence": [ { "id": "Q5EA75", "url": "https://omabrowser.org/oma/group/Q5EA75/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q55BZ4-1", "protein_name": "Ethanolamine-phosphate cytidylyltransferase", "gene_name": "pctA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSTTTNKKPIRVYVDGCFDLMHFGHANALRQARELGDILVVGVHTDEEIAKNKGPPVMNEQERYKAVRACKWADEVAEGAPYTLTEEYLDSLNCDFCVHGEDISVGADGKDVYEGIKKSGKFRFIKRTEGVSTTELVGRMLLCTKDHLQNVSGEQTSPLGGVNPNVLHKQSPYTSLSHFLPTTRKIVQFSEGRSPKPNDKIIYMDGGFDLFHVGHTEALKQARALGDYLIVGVHDDRVVHEQKGSNFPIMNLHERVLSVLSCRYVDEVVIGAPFSVTKDMIDSLHINVVVHGDDQVVLGPEGGVDPYKLPRELGIYKEVKHTEGLTATEIVKRIIDNRLQYEARNRKKEAKEINFIEQSN", "length": 360 }, "evidence": [ { "id": "Q5EA75", "url": "https://omabrowser.org/oma/group/Q5EA75/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q922E4-1", "protein_name": "Ethanolamine-phosphate cytidylyltransferase", "gene_name": "Pcyt2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIRNGHGAASAAGLKGPGDQRIVRVWCDGCYDMVHYGHSNQLRQARAMGDYLIVGVHTDEEIAKHKGPPVFTQEERYKMVQAIKWVDEVVPAAPYVTTLETLDKHNCDFCVHGNDITLTVDGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRMLLVTKAHHSSQEMSSEYREYADSFGKPPHPTPAGDTLSSEVSSQCPGGQSPWTGVSQFLQTSQKIIQFASGKEPQPGETVIYVAGAFDLFHIGHVDFLQEVHKLAKRPYVIAGLHFDQEVNRYKGKNYPIMNLHERTLSVLACRYVSEVVIGAPYSVTAELLNHFKVDLVCHGKTEIVPDRDGSDPYQEPKRRGIFYQIDSGSDLTTDLIVQRIIKNRLEYEARNQKKEAKELAFLEATKQQEAPPGGEID", "length": 404 }, "evidence": [ { "id": "Q5EA75", "url": "https://omabrowser.org/oma/group/Q5EA75/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q99447-1", "protein_name": "Ethanolamine-phosphate cytidylyltransferase", "gene_name": "PCYT2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIRNGRGAAGGAEQPGPGGRRAVRVWCDGCYDMVHYGHSNQLRQARAMGDYLIVGVHTDEEIAKHKGPPVFTQEERYKMVQAIKWVDEVVPAAPYVTTLETLDKYNCDFCVHGNDITLTVDGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRMLLVTKAHHSSQEMSSEYREYADSFGKCPGGRNPWTGVSQFLQTSQKIIQFASGKEPQPGETVIYVAGAFDLFHIGHVDFLEKVHRLAERPYIIAGLHFDQEVNHYKGKNYPIMNLHERTLSVLACRYVSEVVIGAPYAVTAELLSHFKVDLVCHGKTEIIPDRDGSDPYQEPKRRGIFRQIDSGSNLTTDLIVQRIITNRLEYEARNQKKEAKELAFLEAARQQAAQPLGERDGDF", "length": 389 }, "evidence": [ { "id": "Q5EA75", "url": "https://omabrowser.org/oma/group/Q5EA75/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VK25-1", "protein_name": "ethanolamine-phosphate cytidylyltransferase", "gene_name": "Pect", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEANGDTSACNGYSDKQRKDVRVWCDGCYDMVHFGHANSLRQAKALGDKVIVGIHTDEEITKHKGPPVFTEEERVKMVKGIKWVDEVVLGAPYVTTLDVLDQNNCDFCVHGDDITMTAEGVDTYHLVKSANRYKEVKRTAGVSTTDLVGRMLLLTRNHFRQGSAEYDIEKEVSILKRQIKSHPGSSNMGQDSAAKSPWTGCSQFLPTTQKIIQFSDGKSPNPGDKIVYVAGAFDLFHVGHLDFLEKAKKLGDYLIVGLHTDPVVNSYKGSNYPIMNLHERVLSVLACKFVNEVVIGAPYCVTEELLEHFKIDVVCHGRTPIALENGKIDPYAVPKTRAIFELIDSGNEMTTERIVERIISHRLEYERRNQAKEKKEIEAFEALQRQKQTQKAG", "length": 393 }, "evidence": [ { "id": "Q5EA75", "url": "https://omabrowser.org/oma/group/Q5EA75/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9ZVI9-1", "protein_name": "Ethanolamine-phosphate cytidylyltransferase", "gene_name": "PECT1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVWEKEKIVGSCIVGGAAFAVGASFLHLFLKGELPLGLGLGLSCPWRILRKRKPVRVYMDGCFDMMHYGHCNALRQARALGDQLVVGVVSDEEIIANKGPPVTPLHERMTMVKAVKWVDEVISDAPYAITEDFMKKLFDEYQIDYIIHGDDPCVLPDGTDAYALAKKAGRYKQIKRTEGVSSTDIVGRMLLCVRERSISDTHSRSSLQRQFSHGHSSPKFEDGASSAGTRVSHFLPTSRRIVQFSNGKGPGPDARIIYIDGAFDLFHAGHVEILRRARELGDFLLVGIHNDQTVSAKRGAHRPIMNLHERSLSVLACRYVDEVIIGAPWEVSRDTITTFDISLVVHGTVAESDDFRKEEDNPYSVPISMGIFQVLDSPLDITTSTIIRRIVANHEAYQKRNAKKEASEKKYYEQKSFVSGD", "length": 421 }, "evidence": [ { "id": "Q5EA75", "url": "https://omabrowser.org/oma/group/Q5EA75/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5EA75", "url": "https://www.uniprot.org/uniprotkb/Q5EA75" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "phosphatidylethanolamine biosynthetic process", "id": "GO:0006646", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006646", "evidence": [ { "database": "UniProtKB", "id": "Q5EA75", "url": "https://www.uniprot.org/uniprotkb/Q5EA75" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ethanolamine-phosphate cytidylyltransferase activity", "id": "GO:0004306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004306", "evidence": [ { "database": "UniProtKB", "id": "Q5EA75", "url": "https://www.uniprot.org/uniprotkb/Q5EA75" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "24592", "name": "", "equation": "phosphoethanolamine + CTP + H(+) = CDP-ethanolamine + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5EA75-1" ], "evidence": [ { "id": "24592", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24592" } ] }, { "id": "R-BTA-1483190", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-428686" ], "output_participant_list": [], "enzyme_list": [ "Q5EA75-1" ], "evidence": [ { "id": "R-BTA-1483190", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483190" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-428686", "participant_name": "PETA [cytosol]", "crossref": [ { "id": "17553", "database": "ChEBI", "url": "" }, { "id": "C00346", "database": "COMPOUND", "url": "" }, { "id": "ZINC000003870166", "database": "ZINC", "url": "" }, { "id": "HMDB0000224", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q5EA75", "gene_name": "PCYT2", "activity": [ { "ec_number": "2.7.7.14", "activity": "phosphoethanolamine + CTP + H(+) = CDP-ethanolamine + diphosphate.", "evidence": [ { "id": "Q5EA75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA75" } ] }, { "ec_number": "2.7.7.14", "activity": "", "evidence": [ { "id": "Q5EA75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA75" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA75-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 389, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA75-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA75" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.7.14", "ec_name": "phosphoethanolamine + CTP + H(+) = CDP-ethanolamine + diphosphate.", "evidence": [ { "id": "2.7.7.14", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.14" }, { "id": "2.7.7.14", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.7.14" } 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"categories": [ "Genome Annotation" ] }, { "id": "IPR004434", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004434", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019818", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019818", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614145", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614145", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58CP0", "url": "https://www.orthodb.org/?gene=Q58CP0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11835", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11835", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11835:SF78", "url": 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"isoforms": [ { "isoform_ac": "A0A3Q1MRI8-1", "url": "https://www.uniprot.org/uniprotkb/Q58CP0/entry#A0A3Q1MRI8-1", "sequence": { "sequence": "MALKVATAAGGAVKAALRPALLWRPWERKLQSHRAYLGMVGVPTSPARSSADPGQLDNNHWHLGSLCQVLGSHEAPRRSFSQQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSTADEEDIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHRDIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFQLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDIIRHIRVINGRAVEA", "length": 433, "header": "tr|A0A3Q1MRI8-1|IDH3G_BOVIN Computationally mapped isoform of Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial OS=Bos taurus OX=9913 GN=IDH3G PE=2 SV=2 CANONICAL=Q58CP0-1" }, "locus": { "chromosome": "X", "start_pos": 37011440, "end_pos": 37003053, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083935.2", "url": 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37003053, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086787.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086787.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061017.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061017.1" } ] } }, { "isoform_ac": "Q58CP0-1", "url": "https://www.uniprot.org/uniprotkb/Q58CP0/entry#Q58CP0-1", "sequence": { "sequence": "MALKVATAAGGAVKAALRPALLWRPWEVLGSHEAPRRSFSQQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSTADEEDIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHRDIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFQLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDIIRHIRVINGRAVEA", "length": 392, "header": "sp|Q58CP0-1|IDH3G_BOVIN Isoform 1 of Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial OS=Bos taurus OX=9913 GN=IDH3G PE=2 SV=1 CANONICAL=Q58CP0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CP0", "url": "https://www.uniprot.org/uniprotkb/Q58CP0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:614145", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614145", "resource": "KEGG Pathway" }, { "id": "R-BTA-71403", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71403", "resource": "Reactome", "description": "Citric acid cycle (TCA cycle)" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "Q58CP0", "url": "https://www.uniprot.org/uniprotkb/Q58CP0" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q58CP0", "url": "https://www.uniprot.org/uniprotkb/Q58CP0" } ], "pmid": "" }, { "name": "NAD binding", "id": "GO:0051287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051287", "evidence": [ { "database": "UniProtKB", "id": "Q58CP0", "url": "https://www.uniprot.org/uniprotkb/Q58CP0" } ], "pmid": "" }, { "name": "isocitrate dehydrogenase (NAD+) activity", "id": "GO:0004449", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004449", "evidence": [ { "database": "UniProtKB", "id": "Q58CP0", "url": "https://www.uniprot.org/uniprotkb/Q58CP0" } ], "pmid": "" 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subunit protein eS28", "gene_name": "rps28", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNTAATETVQLAKVTEVLCRTGSRGAVTQVRVEFLGTAQGKERTLLRNVKGPVRKDDILCLLETEREARRLR", "length": 72 }, "evidence": [ { "id": "Q56JX6", "url": "https://omabrowser.org/oma/group/Q56JX6/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6PBK3-1", "protein_name": "Small ribosomal subunit protein eS28", "gene_name": "rps28", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDASRVQPIKLARVTKVLGRTGSQGQCTQVRVEFMDDSNRSIIRNVKGPVREGDVLTLLESEREARRLR", "length": 69 }, "evidence": [ { "id": "Q56JX6", "url": "https://omabrowser.org/oma/group/Q56JX6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6QAT1-1", "protein_name": "Small ribosomal subunit protein eS28", "gene_name": "RPS28", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDTSRVQPIKLARVTKVLGRTGSQGQCTQVRVEFMDDTSRSIIRNVKGPVREGDVLTLLESEREARRLR", "length": 69 }, "evidence": [ { "id": "Q56JX6", "url": "https://omabrowser.org/oma/group/Q56JX6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9SR73-1", "protein_name": "Small ribosomal subunit protein eS28z/eS28y", "gene_name": "RPS28A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDSQIKHAVVVKVMGRTGSRGQVTQVRVKFTDSDRYIMRNVKGPVREGDILTLLESEREARRLR", "length": 64 }, "evidence": [ { "id": "Q56JX6", "url": "https://omabrowser.org/oma/group/Q56JX6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "Q56JX6", "url": 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"https://www.uniprot.org/uniprotkb/Q56JX6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "ribosome biogenesis", "id": "GO:0042254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042254", "evidence": [ { "database": "UniProtKB", "id": "Q56JX6", "url": "https://www.uniprot.org/uniprotkb/Q56JX6" } ], "pmid": "" }, { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "Q56JX6", "url": "https://www.uniprot.org/uniprotkb/Q56JX6" } ], "pmid": "" }, { "name": "ribosomal small subunit biogenesis", "id": "GO:0042274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042274", "evidence": [ { "database": "UniProtKB", "id": "Q56JX6", "url": "https://www.uniprot.org/uniprotkb/Q56JX6" } ], "pmid": "" }, { "name": "maturation of SSU-rRNA", "id": "GO:0030490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030490", "evidence": [ { "database": "UniProtKB", "id": "Q56JX6", "url": "https://www.uniprot.org/uniprotkb/Q56JX6" } ], "pmid": "" }, { "name": "ribosomal small subunit assembly", "id": "GO:0000028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000028", "evidence": [ { "database": "UniProtKB", "id": "Q56JX6", "url": "https://www.uniprot.org/uniprotkb/Q56JX6" } ], "pmid": "" }, { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "Q56JX6", "url": "https://www.uniprot.org/uniprotkb/Q56JX6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q56JX6", "url": "https://www.uniprot.org/uniprotkb/Q56JX6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], 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"uniprot_canonical_ac": "A6QM04-1", "uniprot_ac": "A6QM04", "uniprot_id": "ZWILC_BOVIN", "mass": { "chemical_mass": 66385.0, "monoisotopic_mass": 66385.0 }, "refseq": { "ac": "NP_001095649", "name": "protein zwilch homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095649" }, "gene_names": [ { "name": "ZWILCH", "type": "recommended", "evidence": [ { "id": "A6QM04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QM04" } ] }, { "name": "ZWILCH", "type": "synonym", "evidence": [ { "id": "NP_001095649", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095649" } ] } ], "protein_names": [ { "name": "Protein zwilch homolog", "type": "recommended", "evidence": [ { "id": "A6QM04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QM04/entry#names_and_taxonomy" } ] }, { "name": "Zwilch, kinetochore associated, homolog", "type": "synonym", "evidence": [ { "id": "NP_001095649", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095649" } ] }, { "name": "protein zwilch homolog", "type": "synonym", "evidence": [ { "id": "NP_001095649", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095649" } ] } ], "function": [ { "annotation": "Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LGZ8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGZ8#function" }, { "database": "UniProtKB", "id": "RU369076", "url": "https://www.uniprot.org/uniprotkb/RU369076#function" }, { "database": "UniProtKB", "id": "ARBA00054094", "url": "https://www.uniprot.org/uniprotkb/ARBA00054094#function" }, { "database": "UniProtKB", "id": "A6QM04", "url": "https://www.uniprot.org/uniprotkb/A6QM04#function" }, { "database": "UniProtKB", "id": "Q9H900", "url": "https://www.uniprot.org/uniprotkb/Q9H900#function" }, { "database": "UniProtKB", "id": "A0AAF6YNA5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNA5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QM04", "url": "https://www.uniprot.org/uniprotkb/A6QM04" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZWILCH", "url": "https://www.uniprot.org/uniprotkb/A6QM04", "locus": { "chromosome": "10", "start_pos": 13404844, "end_pos": 13362441, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005213", "url": "https://www.ensembl.org/id/ENSBTAG00000005213" } ] } } ], "crossref": [ { "id": "A6QM04", "url": "https://alphafold.ebi.ac.uk/entry/A6QM04", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005213", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005213", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534811", "url": "https://www.ncbi.nlm.nih.gov/gene/534811", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534811", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534811", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PARTTWF", "url": "https://omabrowser.org/oma/group/PARTTWF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LGZ8", "url": "https://www.orthodb.org/?gene=A0A3Q1LGZ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A6QM04", "url": "https://www.orthodb.org/?gene=A6QM04", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15995", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15995", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15995:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15995:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09817", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09817", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-141430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-141444", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2500257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9648025", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001095649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095649", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LGZ8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LGZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YNA5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YNA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNA5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QM04", "url": "https://www.uniprot.org/uniprotkb/A6QM04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QM04-1", "url": "https://www.uniprot.org/uniprotkb/A6QM04-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWSGANRAAEEFYAGLLQEFDENKKGIRKDPFIYEADIQVQLISKGQPNPLKNILHENETIFIVEKVPLEKEEPSPIEELQSEDTAISDLSTGENVGLLALPIGRARQLIGFYTMAHNPNMTHLKINRPVTALPPLWVRCDGSDPEGISWLGAELISTSSNITGIVLYMVTCKVDKNYSVNLEDLKKSHKKRHHLSTLTASGFARYELFKSTALDDTVAASQTTITLDISWSPVDEILQTPPLSSTATLNIKVESGEPRGPLSQLHRELKFLLVLADGLRTGVTEWPEPLEAKSAVELVQEFLNELSKLNEFGDSTKKDTEIVKHDAAAVDGSIECLLTVRGDLDFAEQLWCKMSSSVISYQDLVKCFSLVIQSLQRGAIQPWLHSGSNSLLSKLIHQSYYGTMDTVSLSGTVPVQMLLEIGLDKLKKDYICFFIGQELASLNHLEYFISPSVDTQEQVHRVQKLHHILEIVVSCMLFIKPQHELLFSLTQSCIKYYEQNPLDEQHIFQLPVRPTAVKDLYQNEKPQKWRVEINSGQKKVKTVWQLSDSPPIDHLNFHRPDFSELTLSGSLEERISFTNMVTCSQVHFK", "length": 589, "header": "sp|A6QM04-1|ZWILC_BOVIN Isoform 1 of Protein zwilch homolog OS=Bos taurus OX=9913 GN=ZWILCH PE=2 SV=1 CANONICAL=A6QM04-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LGZ8-1", "url": "https://www.uniprot.org/uniprotkb/A6QM04/entry#A0A3Q1LGZ8-1", "sequence": { "sequence": "RNEIADIQVQLISKGQPNPLKNILHENETIFIVEKVPLEKEEPSPIEELQSEDTAISDLSTGENVGLLALPIGRARQLIGFYTMAHNPNMTHLKINRPVTALPPLWVRCDGSDPEGISWLGAELISTSSNITGIVLYMVTCKVDKNYSVNLEDLKKSHKKRHHLSTLTASGFARYELFKSTALDDTVAASQTTITLDISWSPVDEILQTPPLSSTATLNIKVESGEPRGPLSQLHRELKFLLVLADGLRTGVTEWPEPLEAKSAVELVQEFLNELSKLNEFGDSTKKDTEIVKHDAAAVDGSIECLLTVRGDLDFAEQLWCKMSSSVISYQDLVKCFSLVIQSLQRGAIQPWLHSGSNSLLSKLIHQSYYGTMDTVSLSGTVPVQMLLEIGLDKLKKDYICFFIGKSLSQLKKEYFISPSVDTQEQVHRVQKLHHILEIVVSCMLFIKPQHELLFSLTQSCIKYYEQNPLDEQHIFQLPVRPTAVKDLYQNEKPQKWRVEINSGQKKVKTVWQLSDSPPIDHLNFHRPDFSELTLSGSLEERISFTNMVTCSQVHFK", "length": 557, "header": "tr|A0A3Q1LGZ8-1|ZWILC_BOVIN Computationally mapped isoform of Protein zwilch homolog OS=Bos taurus OX=9913 GN=ZWILCH PE=2 SV=2 CANONICAL=A6QM04-1" }, "locus": { "chromosome": "10", "start_pos": 13403052, "end_pos": 13370973, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086764.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086764.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057877.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057877.2" } ] } }, { "isoform_ac": "A0AAF6YNA5-1", "url": "https://www.uniprot.org/uniprotkb/A6QM04/entry#A0AAF6YNA5-1", "sequence": { "sequence": "MGVKVVPARKSRPRTSAPGAHFSLAVSGVRSNWGAMWSGANRAAEEFYAGLLQEFDENKKGIRKDPFIYEADIQVQLISKGQPNPLKNILHENETIFIVEKVPLEKEEPSPIEELQSEDTAISDLSTGENVGLLALPIGRARQLIGFYTMAHNPNMTHLKINRPVTALPPLWVRCDGSDPEGISWLGAELISTSSNITGIVLYMVTCKVDKNYSVNLEDLKKSHKKRHHLSTLTASGFARYELFKSTALDDTVAASQTTITLDISWSPVDEILQTPPLSSTATLNIKVESGEPRGPLSQLHRELKFLLVLADGLRTGVTEWPEPLEAKSAVELVQEFLNELSKLNEFGDSTKKDTEIVKHDAAAVDGSIECLLTVRGDLDFAEQLWCKMSSSVISYQDLVKCFSLVIQSLQRGAIQPWLHSGSNSLLSKLIHQSYYGTMDTVSLSGTVPVQMLLEIGLDKLKKDYICFFIGQELASLNHLEYFISPSVDTQEQVHRVQKLHHILEIVVSCMLFIKPQHELLFSLTQSCIKYYEQNPLDEQHIFQLPVRPTAVKDLYQNEKPQKWRVEINSGQKKVKTVWQLSDSPPIDHLNFHRPDFSELTLSGSLEERISFTNMVTCSQVHFK", "length": 624, "header": "tr|A0AAF6YNA5-1|ZWILC_BOVIN Computationally mapped isoform of Protein zwilch homolog OS=Bos taurus OX=9913 GN=ZWILCH PE=2 SV=1 CANONICAL=A6QM04-1" }, "locus": { "chromosome": "10", "start_pos": 13403052, "end_pos": 13362516, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006867.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006867.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006867.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006867.6" } ] } }, { "isoform_ac": "A6QM04-1", "url": "https://www.uniprot.org/uniprotkb/A6QM04/entry#A6QM04-1", "sequence": { "sequence": "MWSGANRAAEEFYAGLLQEFDENKKGIRKDPFIYEADIQVQLISKGQPNPLKNILHENETIFIVEKVPLEKEEPSPIEELQSEDTAISDLSTGENVGLLALPIGRARQLIGFYTMAHNPNMTHLKINRPVTALPPLWVRCDGSDPEGISWLGAELISTSSNITGIVLYMVTCKVDKNYSVNLEDLKKSHKKRHHLSTLTASGFARYELFKSTALDDTVAASQTTITLDISWSPVDEILQTPPLSSTATLNIKVESGEPRGPLSQLHRELKFLLVLADGLRTGVTEWPEPLEAKSAVELVQEFLNELSKLNEFGDSTKKDTEIVKHDAAAVDGSIECLLTVRGDLDFAEQLWCKMSSSVISYQDLVKCFSLVIQSLQRGAIQPWLHSGSNSLLSKLIHQSYYGTMDTVSLSGTVPVQMLLEIGLDKLKKDYICFFIGQELASLNHLEYFISPSVDTQEQVHRVQKLHHILEIVVSCMLFIKPQHELLFSLTQSCIKYYEQNPLDEQHIFQLPVRPTAVKDLYQNEKPQKWRVEINSGQKKVKTVWQLSDSPPIDHLNFHRPDFSELTLSGSLEERISFTNMVTCSQVHFK", "length": 589, "header": "sp|A6QM04-1|ZWILC_BOVIN Isoform 1 of Protein zwilch homolog OS=Bos taurus OX=9913 GN=ZWILCH PE=2 SV=1 CANONICAL=A6QM04-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 88, "end_pos": 88, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QM04", "url": "https://www.uniprot.org/uniprotkb/A6QM04" } ], "site_lbl": "Ser88" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534811", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534811", "resource": "KEGG Pathway" }, { "id": "R-BTA-141430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "resource": "Reactome", "description": "Inactivation of APC/C via direct inhibition of the APC/C complex" }, { "id": "R-BTA-141444", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "resource": "Reactome", "description": "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2500257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "resource": "Reactome", "description": "Resolution of Sister Chromatid Cohesion" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" }, { "id": "R-BTA-9648025", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "resource": "Reactome", "description": "EML4 and NUDC in mitotic spindle formation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BRV4-1", "protein_name": "Protein zwilch", "gene_name": "ZWILCH", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MWLRMNQAAEEFYALLLKKFNEEKKGICKDPLIYEADVQVQLISKGQPNPLKNILNESDIVFVVENVPLEKEETSHVEELQSEATAISDFSTSENAGPLAIPVGRARQLIGLYTMAHNPNMTHLKINRPVTALPPLWVRCDSSDPEGTCWLGAELITTNNDITGIVLYMVTCKADKNFSVKLEDLKNLHMKRHHLSTLTARGFAQYELFKSTALDDISAASQTTITLDISWSPVDEILQIPPLSSTATLNIKVESGEPRGPLSHLHRELKFLLVLAVGLRTGVTEWPEPLEAKSAVELVQEFLNDLNTLNGFGDSTKKDTEAVKHDSAAVDQSMACLLTVRGDLDFAEQLWCKMSSTVISYQDLVKCFALIIQSLQRGDIQPWLHSGSNSLLSKLIHQSYHGTMDTVSLSGTVPVQMLLEIGLDKLKKDYICFFIGQELASLNHLEYFISPSVDTHEKVYRVQKLHHILEIVVSCMLFIKPQHELLFSLTQSCIKYYKQNPLDEQHIFQLPIRPTAIKNLYQNEKPQKWRVEINSGQKKVKTVWQLSDSPPFDHLSFHKPDFSELTLNGSLEERISFINMVTCSQVHFK", "length": 589 }, "evidence": [ { "id": "A6QM04", "url": "https://omabrowser.org/oma/group/A6QM04/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YY18-1", "protein_name": "Protein zwilch", "gene_name": "ZWILCH", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGTERRREAAVGLYLTLLRIYEEGKKSVPERPYLFEDDVEICFIDGSCKSPVERFWNGSSMLYVLQQAGRSEDSDPTGEPGADDALHTSQLTPTEGTSPAALPVQRAKQLISLYTMAQNPDMTHLKISDLVVLPPLWIRCDGSDPEHTYWLGAEPLKAGNKITGISFHMVTCDGPTADKTSFVNLEELKTEHKVKHHSSVVTTKGFAQYELISAAAMDDTTLGSESNISIDITWHTVDKILQAPPLCSTATLNIMLESGDPRSPVYPLYRELQFLLALAEGLKTGVTEWPEHLETQTAFELVQEFLMDLKKKLDGCCVSGDKNETESIKSDTAAVDSSIKSIFSERGDLDFAEQLWCKMRSVCSYQELVECLTLVIKFLEHGEIQPWIHQGSSSLLSKLIQQSYHGKVEAVSLSGITPIQMLLEIGLDKMKKDYVSFFIGQELTTLTYLDYFISTSVDLQEQVHRVQKLHHMLEIMVSCTVLLQFKHENLFPLTQTCLKYYKENPLNEKQVFQLPIRPAFVKKFYQNDYPEMWKVDITSGHGPKEVKTTWQVSADPPVEHMTSNNTGLFCDSTFNGSSEERMYFVAMAKCSQVHFT", "length": 596 }, "evidence": [ { "id": "A6QM04", "url": "https://omabrowser.org/oma/group/A6QM04/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A5WWB6-1", "protein_name": "Protein zwilch homolog", "gene_name": "zwilch", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGSKIVSDANAFVKFLKLCQDESKDNCTYMDDVSVLLVKKEQLLHDIIGEKNQPIFICEKAQTKYEPEATETSADTSDVEDVLFKVEQDPGPQPLSIMKARQLLSWYTMAHNPNMSRLKAPENLHPLWVRCDKSDPCATAWLGVEITYSGNKTSGVKLYTVCCKGPTGDETAFTTLDELKQEHQNRHHTSAVSTKGYAQYNLFCSLTEESLMFESQSSVIASLTWNHVEKMLECPPLSSKATLNIKVAVGDIRSPLYQTYREMEFLLALAGGLRTGEIEWLEPVETQSAVDLTRALIEELENLAHGVPGHSAKASEKQKAKPDAAFSSMVIERGDLDFTEQLWEKMRKSVTSYQDITECMKIVVKAVKLGKIKPWIHKDSNSTLSKLILQSYQQQIDSVPLTGLAPANMLLELGLDKIRKDFINYLVGKELTTLNYLSYYLDTEVDLQEQVVRVRKLHHLLEILGTCSTFLSLPHERLFLFTQSCLQYYKTSNYDEDHIFQLQIKPALISYFYEKEQPFSWAVEVSSGQGSKEVKTSLYLSDKPLVDHIHLDLDVSLNESVNGDSEKMFYYRTMVSCSLINFI", "length": 583 }, "evidence": [ { "id": "A6QM04", "url": "https://omabrowser.org/oma/group/A6QM04/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZG58-1", "protein_name": "Protein zwilch", "gene_name": "Zwilch", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTYIPSLAENGVPTHSLCVRVQLQHDPQILQWILLQDSALNLLAIKIKREFNEEKKGIRKDPFIYEADVQVQLVSKKAQPNLLKTLLNENDLVFLVEKVVLEKEETSHVEEPQSEETAISDLSTGENIRPLALPVGRARQLIGLYTMAHNPNMTHLKIKQPVTALPPLWVRCDSSDPESTCWLGAELITANGAVTDVVLYVVTCKADKNYSENLENLKNLHKKRHHLSAVTARGFAQFELFKSTDLDDTVTPSQTTVTLDLSWSPVDEILQTPPLSSTATLNIRVQSGEPRGCLNHLHRELKFLLVLADGIRTGVTEWLEPLETKSAVESVQEFLNDLNKLDEFDDSTKKDTQKEAVNHDTAAVVRSMLVTVRGDLDFAEQLWCKMSSSVVSYQDLVKCFTLILQSLQCGDIQPWLHSGSNSLLSKLIHQSYHAAMDSVPLSGTTPLQMLLEIGLDKLKKDYISFFVSQELASLNHLEYFISPSVTTQEQVHRVRKLHHILEILVICMLFIKPQHELLFSLTQSCIKYYKQNPLDEQHIFQLPVRPAALKNLYQSEKPQKWRVEIGSSQKKVKTVWQLSECSPVDHCSFHKPEFSELTLNGSLEERAAFINMVTCSQVHFK", "length": 621 }, "evidence": [ { "id": "A6QM04", "url": "https://omabrowser.org/oma/group/A6QM04/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R060-1", "protein_name": "Protein zwilch homolog", "gene_name": "Zwilch", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWSRMNRAAEEFYARLRQEFNEEKKGASKDPFIYEADVQVQLISKGQPSLLKTILNENDSVFLVEKVVLEKEETSQVEELQSEETAISDLSAGENIRPLALPVGRARQLIGLYTMAHNPNMTHLKIKQPVTALPPLWVRCDGSDPEGTCWLGAELITTNDIIAGVILYVLTCKADKNYSEDLENLKTSHKKRHHVSAVTARGFAQYELFKSDDLDDTVAPSQTTVTLDLSWSPVDEMLQTPPLSSTAALNIRVQSGESRGCLSHLHRELKFLLVLADGIRTGVTEWLEPLETKSALEFVQEFLNDLNKLDEFDDSTKKDKQKEAVNHDAAAVVRSMLLTVRGDLDFAEQLWCRMSSSVVSYQDLVKCFTLILQSLQRGDIQPWLHSGSNSLLSKLIHQSYHGAMDSVPLSGTTPLQMLLEIGLDKLKKDYISFFVSQELASLNHLEYFISPSVSTQEQVCRVQKLHHILEILVICMLFIKPQHELLFSLTQSCIKYYKQNPLDEQHIFQLPVRPAAVKNLYQSEKPQKWRVELSNSQKRVKTVWQLSDSSPVDHSSFHRPEFPELTLNGSLEERTAFVNMLTCSQVHFK", "length": 589 }, "evidence": [ { "id": "A6QM04", "url": "https://omabrowser.org/oma/group/A6QM04/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H900-1", "protein_name": "Protein zwilch homolog", "gene_name": "ZWILCH", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWERLNCAAEDFYSRLLQKFNEEKKGIRKDPFLYEADVQVQLISKGQPNPLKNILNENDIVFIVEKVPLEKEETSHIEELQSEETAISDFSTGENVGPLALPVGKARQLIGLYTMAHNPNMTHLKINLPVTALPPLWVRCDSSDPEGTCWLGAELITTNNSITGIVLYVVSCKADKNYSVNLENLKNLHKKRHHLSTVTSKGFAQYELFKSSALDDTITASQTAIALDISWSPVDEILQIPPLSSTATLNIKVESGEPRGPLNHLYRELKFLLVLADGLRTGVTEWLEPLEAKSAVELVQEFLNDLNKLDGFGDSTKKDTEVETLKHDTAAVDRSVKRLFKVRSDLDFAEQLWCKMSSSVISYQDLVKCFTLIIQSLQRGDIQPWLHSGSNSLLSKLIHQSYHGTMDTVSLSGTIPVQMLLEIGLDKLKKDYISFFIGQELASLNHLEYFIAPSVDIQEQVYRVQKLHHILEILVSCMPFIKSQHELLFSLTQICIKYYKQNPLDEQHIFQLPVRPTAVKNLYQSEKPQKWRVEIYSGQKKIKTVWQLSDSSPIDHLNFHKPDFSELTLNGSLEERIFFTNMVTCSQVHFK", "length": 591 }, "evidence": [ { "id": "A6QM04", "url": "https://omabrowser.org/oma/group/A6QM04/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "RZZ complex", "id": "GO:1990423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990423", "evidence": [ { "database": "UniProtKB", "id": "A6QM04", "url": "https://www.uniprot.org/uniprotkb/A6QM04" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A6QM04", "url": "https://www.uniprot.org/uniprotkb/A6QM04" } ], "pmid": "" }, { "name": "mitotic spindle assembly checkpoint signaling", "id": "GO:0007094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007094", "evidence": [ { "database": "UniProtKB", "id": "A6QM04", "url": "https://www.uniprot.org/uniprotkb/A6QM04" } ], "pmid": "" }, { "name": "protein localization to kinetochore", "id": "GO:0034501", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034501", "evidence": [ { "database": "UniProtKB", "id": "A6QM04", "url": "https://www.uniprot.org/uniprotkb/A6QM04" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" }, { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QM04-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 589, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QM04-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QM04" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 88 ], "sequon_annotation_sites": [ { "start_pos": 120, "end_pos": 122 }, { "start_pos": 161, "end_pos": 163 }, { "start_pos": 177, "end_pos": 179 }, { "start_pos": 58, "end_pos": 60 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q6IED8-1", "uniprot_ac": "Q6IED8", "uniprot_id": "IFI6_BOVIN", "mass": { "chemical_mass": 13992.0, "monoisotopic_mass": 13992.0 }, "refseq": { "ac": "NP_001069056", "name": "interferon alpha-inducible protein 6 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069056" }, "gene_names": [ { "name": "IFI6", "type": "recommended", "evidence": [ { "id": "Q6IED8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6IED8" } ] }, { "name": "6-16", "type": 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Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane invaginations, which are double-membrane vesicles that flaviviruses use for their replication. Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis. However, it has also been shown to have a pro-apoptotic activity. 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"MRQKAVSLFLCYLLLYTCGCCEEEDEKRYSEENSDSSFWGMVTYMAVGGGLMAAALPMLGFASTGIAANSLASSLMSWSAVANGGGVPAGGLVATLQSLGASGGSALMAKIGAFLGYTVHKQVESRQKESKEKK", "length": 134, "header": "sp|Q6IED8-1|IFI6_BOVIN Isoform 1 of Interferon alpha-inducible protein 6 OS=Bos taurus OX=9913 GN=IFI6 PE=2 SV=1 CANONICAL=Q6IED8-1" }, "locus": { "chromosome": "2", "start_pos": 125665649, "end_pos": 125663683, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000141093.1", "url": "https://www.ensembl.org/id/ENSBTAT00000141093.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107005.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107005.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12.", "journal": "BMC Genomics", "date": "2004", "authors": "Parker Nadeene, Porter Andrew C G", "evidence": [ { "database": 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"glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "Q6IED8", "url": "https://www.uniprot.org/uniprotkb/Q6IED8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q6IED8", "url": "https://www.uniprot.org/uniprotkb/Q6IED8" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q6IED8", "url": "https://www.uniprot.org/uniprotkb/Q6IED8" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": 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"Q5E960", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E960/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 39 (zinc transporter), member 3", "type": "synonym", "evidence": [ { "id": "NP_001015521", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015521" } ] }, { "name": "zinc transporter ZIP3", "type": "synonym", "evidence": [ { "id": "NP_001015521", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015521" } ] }, { "name": "zrt- and Irt-like protein 3", "type": "synonym", "evidence": [ { "id": "NP_001015521", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015521" } ] } ], "function": [ { "annotation": "Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus. Mediates Zn(2+) reuptake from the secreted milk within the alveolar lumen.", "evidence": [ { "database": "UniProtKB", "id": "Q5E960", "url": "https://www.uniprot.org/uniprotkb/Q5E960#function" }, { "database": "UniProtKB", "id": "Q99K24", "url": "https://www.uniprot.org/uniprotkb/Q99K24#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E960", "url": "https://www.uniprot.org/uniprotkb/Q5E960" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC39A3", "url": "https://www.uniprot.org/uniprotkb/Q5E960", "locus": { "chromosome": "7", "start_pos": 20943200, "end_pos": 20936284, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017706", "url": "https://www.ensembl.org/id/ENSBTAG00000017706" } ] } } ], "crossref": [ { "id": "Q5E960", "url": "https://alphafold.ebi.ac.uk/entry/Q5E960", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017706", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017706", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505294", "url": "https://www.ncbi.nlm.nih.gov/gene/505294", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003689", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003689", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505294", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505294", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HHHGHFN", "url": "https://omabrowser.org/oma/group/HHHGHFN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E960", "url": "https://www.orthodb.org/?gene=Q5E960", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11040", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11040", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11040:SF221", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11040:SF221", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02535", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02535", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-442380", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-442380", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015521", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015521", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29351", "url": "https://www.rhea-db.org/rhea/29351", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6Z4R9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z4R9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E960", "url": "https://www.uniprot.org/uniprotkb/Q5E960", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E960-1", "url": "https://www.uniprot.org/uniprotkb/Q5E960-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVKLLVAKILCMVGMFFFMLLGSLLPVKIIEMDFEKAHRSKKILSLCNTFGGGVFLATCFNALLPAVREKLKEVLTLAHISTDYPLAETIMLLGFFMTVFLEQLVLTFRKERPAFIDLETFNASSDAGSDSEYESPFMGGPRGHALYAEPHGHSHGLSVQELSRSSPLRLLSLVFALSAHSVFEGLALGLQEEGEKVVSLFVGVAIHETLVAVALGINMARSAMALRDAAKLAVTVSAMIPLGISLGLGIDSAQGMPSSVASVLLQGLAGGTFLFVTFFEILAKELEEKSDRLLKVLFLVLGYTVLAGMVFIKW", "length": 314, "header": "sp|Q5E960-1|S39A3_BOVIN Isoform 1 of Zinc transporter ZIP3 OS=Bos taurus OX=9913 GN=SLC39A3 PE=2 SV=2 CANONICAL=Q5E960-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z4R9-1", "url": "https://www.uniprot.org/uniprotkb/Q5E960/entry#A0AAF6Z4R9-1", "sequence": { "sequence": "MVKLLVAKILCMVGMFFFMLLGSLLPVKIIEMDFEKAHRSKKILSLCNTFGGGVFLATCFNALLPAVREKLKEVLTLAHISTDYPLAETIMLLGFFMTVFLEQLVLTFRKERPAFIDLETFNASSDAGSDSEYESPFMGGPRGHALYAEPHGHSHGLSVQELSRSSPLRLLSLVFALSAHSVFEGLALGLQEEGEKVVSLFVGVAIHETLVAVALGINMARSAMALRDAAKLAVTGLAGGTFLFVTFFEILAKELEEKSDRLLKVLFLVLGYTVLAGMVFIKW", "length": 283, "header": "tr|A0AAF6Z4R9-1|S39A3_BOVIN Computationally mapped isoform of Zinc transporter ZIP3 OS=Bos taurus OX=9913 GN=SLC39A3 PE=2 SV=1 CANONICAL=Q5E960-1" }, "locus": { "chromosome": "7", "start_pos": 20942700, "end_pos": 20937940, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023551.5", "url": "https://www.ensembl.org/id/ENSBTAT00000023551.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023551.4", "url": "https://www.ensembl.org/id/ENSBTAP00000023551.4" } ] } }, { "isoform_ac": "Q5E960-1", "url": "https://www.uniprot.org/uniprotkb/Q5E960/entry#Q5E960-1", "sequence": { "sequence": "MVKLLVAKILCMVGMFFFMLLGSLLPVKIIEMDFEKAHRSKKILSLCNTFGGGVFLATCFNALLPAVREKLKEVLTLAHISTDYPLAETIMLLGFFMTVFLEQLVLTFRKERPAFIDLETFNASSDAGSDSEYESPFMGGPRGHALYAEPHGHSHGLSVQELSRSSPLRLLSLVFALSAHSVFEGLALGLQEEGEKVVSLFVGVAIHETLVAVALGINMARSAMALRDAAKLAVTVSAMIPLGISLGLGIDSAQGMPSSVASVLLQGLAGGTFLFVTFFEILAKELEEKSDRLLKVLFLVLGYTVLAGMVFIKW", "length": 314, "header": "sp|Q5E960-1|S39A3_BOVIN Isoform 1 of Zinc transporter ZIP3 OS=Bos taurus OX=9913 GN=SLC39A3 PE=2 SV=2 CANONICAL=Q5E960-1" }, "locus": { "chromosome": "7", "start_pos": 20942700, "end_pos": 20937940, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000146412.1", "url": "https://www.ensembl.org/id/ENSBTAT00000146412.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104993.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104993.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 125, "end_pos": 125, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E960", "url": "https://www.uniprot.org/uniprotkb/Q5E960" } ], "site_lbl": "Ser125" }, { "start_pos": 129, "end_pos": 129, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E960", "url": "https://www.uniprot.org/uniprotkb/Q5E960" } ], "site_lbl": "Ser129" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E960", "url": "https://www.uniprot.org/uniprotkb/Q5E960" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:505294", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505294", "resource": "KEGG Pathway" }, { "id": "R-BTA-442380", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-442380", "resource": "Reactome", "description": "Zinc influx into cells by the SLC39 gene family" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2U760-1", "protein_name": "Zinc transporter ZIP3", "gene_name": "SLC39A3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKIVAAKVLCLLGICVLMLAGSLLPVKIIQADHEKAHRSRKVISLCNSFGGGVFLATCFNALLPAVRGKLDEVLKQGNVTTDYPVAETIMVLGFFMTVFVEQLVLTFQKEKPSFIDLETFNAGSDVGSDSEYESPFIASSRGGALYAEHSRHSHGHGLNIHELSRSGPLRLVSLVFALCTHSIFEGLALGLQEEGGRVLSLFLGVAIHETLVAVALGISMAKASLPLKDAAKLAVTVSLMIPLGISIGMGIESTQSAAGNITSLLLQGVAGGTFLFITFFEILAKELEDKSNRLLKVLFLVLGYAALAGLVFLKW", "length": 315 }, "evidence": [ { "id": "Q5E960", "url": "https://omabrowser.org/oma/group/Q5E960/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q12436-1", "protein_name": "Low-affinity zinc transporter ZRT2", "gene_name": "ZRT2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MVDLIARDDSVDTCQASNGYNGHAGLRILAVFIILISSGLGVYFPILSSRYSFIRLPNWCFFIAKFFGSGVIVATAFVHLLQPAAEALGDECLGGTFAEYPWAFGICLMSLFLLFFTEIITHYFVAKTLGHDHGDHGEVTSIDVDAPSSGFVIRNMDSDPVSFNNEAAYSIHNDKTPYTTRNEEIVATPIKEKEPGSNVTNYDLEPGKTESLANELVPTSSHATNLASVPGKDHYSHENDHQDVSQLATRIEEEDKEQYLNQILAVFILEFGIIFHSVFVGLSLSVAGEEFETLFIVLTFHQMFEGLGLGTRVAETNWPESKKYMPWLMGLAFTLTSPIAVAVGIGVRHSWIPGSRRALIANGVFDSISSGILIYTGLVELMAHEFLYSNQFKGPDGLKKMLSAYLIMCCGAALMALLGKWA", "length": 422 }, "evidence": [ { "id": "Q5E960", "url": "https://omabrowser.org/oma/group/Q5E960/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q5U1X7-1", "protein_name": "Zinc transporter ZIP3", "gene_name": "Slc39a3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSQLLVAKVLCMVGVFFFMLLGSLLPVKVIEADFEKAHRSKKVLSLCNTFGGGVFLATCFNALLPAVRDKLQQVLSLGHISTDYPLAETLMMVGFFLTVFVEQLVLTFRRERPPFIDLETFNAGSDAGSDSEYESPFVGVGGRNHGLYPEPTAHSHGTGLRLRELGRPGPLRLLSLVFALSAHSVFEGLALGLQEEGERVVSLFVGVAVHETLVAVALGISMARSAVPLRDAAKLAVTVSAMIPVGIGLGLGIESARSVASSVASALLQGLAGGTFLFVTFLEILAKELEERSEQLLKVLFLVLGYAVLAGMVFLKW", "length": 317 }, "evidence": [ { "id": "Q5E960", "url": "https://omabrowser.org/oma/group/Q5E960/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99K24-1", "protein_name": "Zinc transporter ZIP3", "gene_name": "Slc39a3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTKLLVAKVLCMVGVFFFMLLGSLLPVKVIEADLEKAHRSKKVLSLCNTFGGGVFLATCFNALLPAVRDKLQQVLSLGHISTDYPLAETLMMVGFFLTVFVEQLVLTFRRERPPFIDLETFNAGSDAGSDSEYESPFVGVGNRSHSLYPEPTAHTHGAGLRLRELGRPGPLRLLSLVFALSAHSVFEGLALGLQEEGERVVSLFVGVAIHETLVAVALGISMARSAVPLRDAAKLAVTVSAMIPVGIGLGLGIESARSVASSVASALLQGLAGGTFLFVTFLEILAKELEERSEQLLKVLFLVLGYAVLAGMVFLKW", "length": 317 }, "evidence": [ { "id": "Q5E960", "url": "https://omabrowser.org/oma/group/Q5E960/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BRY0-1", "protein_name": "Zinc transporter ZIP3", "gene_name": "SLC39A3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVKLLVAKILCMVGVFFFMLLGSLLPVKIIETDFEKAHRSKKILSLCNTFGGGVFLATCFNALLPAVREKLQKVLSLGHISTDYPLAETILLLGFFMTVFLEQLILTFRKEKPSFIDLETFNAGSDVGSDSEYESPFMGGARGHALYVEPHGHGPSLSVQGLSRASPVRLLSLAFALSAHSVFEGLALGLQEEGEKVVSLFVGVAVHETLVAVALGISMARSAMPLRDAAKLAVTVSAMIPLGIGLGLGIESAQGVPGSVASVLLQGLAGGTFLFITFLEILAKELEEKSDRLLKVLFLVLGYTVLAGMVFLKW", "length": 314 }, "evidence": [ { "id": "Q5E960", "url": "https://omabrowser.org/oma/group/Q5E960/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9SLG3-1", "protein_name": "Zinc transporter 3", "gene_name": "ZIP3", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MKTKNVKLLFFFFSVSLLLIAVVNAAEGHSHGGPKCECSHEDDHENKAGARKYKIAAIPTVLIAGIIGVLFPLLGKVFPSLRPETCFFFVTKAFAAGVILATGFMHVLPEAYEMLNSPCLTSEAWEFPFTGFIAMIAAILTLSVDTFATSSFYKSHCKASKRVSDGETGESSVDSEKVQILRTRVIAQVLELGIIVHSVVIGISLGASQSPDAAKALFIALMFHQCFEGLGLGGCIAQGKFKCLSVTIMSTFFAITTPIGIVVGMGIANSYDESSPTALIVQGVLNAASAGILIYMSLVDLLAADFTHPKMQSNTGLQIMAHIALLLGAGLMSLLAKWA", "length": 339 }, "evidence": [ { "id": "Q5E960", "url": "https://omabrowser.org/oma/group/Q5E960/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion transmembrane transporter activity", "id": "GO:0005385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005385", "evidence": [ { "database": "UniProtKB", "id": "Q5E960", "url": "https://www.uniprot.org/uniprotkb/Q5E960" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "zinc ion transmembrane transport", "id": "GO:0071577", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071577", "evidence": [ { "database": "UniProtKB", "id": "Q5E960", "url": "https://www.uniprot.org/uniprotkb/Q5E960" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q5E960", "url": "https://www.uniprot.org/uniprotkb/Q5E960" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "Q5E960", "url": "https://www.uniprot.org/uniprotkb/Q5E960" } ], "pmid": "" }, { "name": "hippocampal mossy fiber to CA3 synapse", "id": "GO:0098686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098686", "evidence": [ { "database": "UniProtKB", "id": "Q5E960", "url": "https://www.uniprot.org/uniprotkb/Q5E960" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29351", "name": "", "equation": "Zn(2+)(in) = Zn(2+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MPF0-1", "A0AAA9RSQ6-1" ], "evidence": [ { "id": "29351", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29351" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E960-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 314, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", 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}, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9C2-1", "uniprot_ac": "Q5E9C2", "uniprot_id": "DAD1_BOVIN", "mass": { "chemical_mass": 12495.0, "monoisotopic_mass": 12495.0 }, "refseq": { "ac": "NP_001029933", "name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029933" }, "gene_names": [ { "name": "DAD1", "type": "recommended", "evidence": [ { "id": "Q5E9C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2" } ] }, { "name": "DAD1", "type": "synonym", "evidence": [ { "id": "NP_001029933", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029933" } ] } ], "protein_names": [ { "name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "type": "recommended", "evidence": [ { "id": "Q5E9C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2/entry#names_and_taxonomy" } ] }, { "name": "DAD-1", "type": "synonym", "evidence": [ { "id": "NP_001029933", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029933" }, { "id": "Q5E9C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2/entry#names_and_taxonomy" } ] }, { "name": "Defender against cell death 1", "type": "synonym", "evidence": [ { "id": "Q5E9C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2/entry#names_and_taxonomy" } ] }, { "name": "Oligosaccharyl transferase subunit DAD1", "type": "synonym", "evidence": [ { "id": "Q5E9C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2/entry#names_and_taxonomy" } ] }, { "name": "defender against death (DAD1)", "type": "synonym", "evidence": [ { "id": "NP_001029933", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029933" } ] }, { "name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "type": "synonym", "evidence": [ { "id": "NP_001029933", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029933" } ] }, { "name": "oligosaccharyl transferase subunit DAD1", "type": "synonym", "evidence": [ { "id": "NP_001029933", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029933" } ] } ], "function": [ { "annotation": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z6H0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6H0#function" }, { "database": "UniProtKB", "id": "RU361136", "url": "https://www.uniprot.org/uniprotkb/RU361136#function" }, { "database": "UniProtKB", "id": "Q5E9C2", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2#function" }, { "database": "UniProtKB", "id": "E2R4X3", "url": "https://www.uniprot.org/uniprotkb/E2R4X3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9C2", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DAD1", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2", "locus": { "chromosome": "10", "start_pos": 22251127, "end_pos": 22229642, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019077", "url": "https://www.ensembl.org/id/ENSBTAG00000019077" } ] } } ], "crossref": [ { "id": "Q5E9C2", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9C2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019077", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019077", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614538", "url": "https://www.ncbi.nlm.nih.gov/gene/614538", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614538", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614538", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HIILHIV", "url": "https://omabrowser.org/oma/group/HIILHIV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9C2", "url": "https://www.orthodb.org/?gene=Q5E9C2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10705", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10705", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10705:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10705:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02109", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02109", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9768727", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9768727", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9931295", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931295", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029933", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6Z6H0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6H0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z6H0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z6H0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9C2", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9C2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSASVLSVISRFLEEYLSATPQRLKLLDAYLLYILLTGALQFGYCLLVGTFPFNSFLSGFISCVGSFILAVCLRIQINPQNKADFQGISPERAFADFLFASTILHLVVMNFVG", "length": 113, "header": "sp|Q5E9C2-1|DAD1_BOVIN Isoform 1 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 OS=Bos taurus OX=9913 GN=DAD1 PE=3 SV=3 CANONICAL=Q5E9C2-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z6H0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2/entry#A0AAF6Z6H0-1", "sequence": { "sequence": "MSASVLSVISRFLEEYLSATPQRLKLLDAYLLYILLTGALQFGYCLLVGTFPFNSFLSGFISCVGSFILAGSLFNFPG", "length": 78, "header": "tr|A0AAF6Z6H0-1|DAD1_BOVIN Computationally mapped isoform of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 OS=Bos taurus OX=9913 GN=DAD1 PE=3 SV=1 CANONICAL=Q5E9C2-1" }, "locus": { "chromosome": "10", "start_pos": 22241249, "end_pos": 22229642, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025397.4", "url": "https://www.ensembl.org/id/ENSBTAT00000025397.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025397.3", "url": "https://www.ensembl.org/id/ENSBTAP00000025397.3" } ] } }, { "isoform_ac": "Q5E9C2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2/entry#Q5E9C2-1", "sequence": { "sequence": "MSASVLSVISRFLEEYLSATPQRLKLLDAYLLYILLTGALQFGYCLLVGTFPFNSFLSGFISCVGSFILAVCLRIQINPQNKADFQGISPERAFADFLFASTILHLVVMNFVG", "length": 113, "header": "sp|Q5E9C2-1|DAD1_BOVIN Isoform 1 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 OS=Bos taurus OX=9913 GN=DAD1 PE=3 SV=3 CANONICAL=Q5E9C2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C2", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:614538", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614538", "resource": "KEGG Pathway" }, { "id": "R-BTA-9768727", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9768727", "resource": "Reactome", "description": "Regulation of CDH1 posttranslational processing and trafficking to plasma membrane" }, { "id": "R-BTA-9931295", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931295", "resource": "Reactome", "description": "PD-L1(CD274) glycosylation and translocation to plasma membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "G3HRC5-1", "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "gene_name": "Dad1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSASVVSVISRFLEEYLSSTPQRLKLLDAYLLYILLTGALQFGYCLLVGTFPFNSFLSGFISCVGSFILAVCLRIQINPQNKADFQGISPERAFADFLFASTILHLVVMNFVG", "length": 113 }, "evidence": [ { "id": "Q5E9C2", "url": "https://omabrowser.org/oma/group/Q5E9C2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O13113-1", "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "gene_name": "DAD1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGTAGSGVGAAGSVGSVVRRFLAEYGSGTSSRLKVLDAYLLYVMLTGALQFGYCLGVGTFPFNSFLSGFISAVGSFILGVCLRIQINPQNKGEFQGISPERAFADFLFANTILHLVVINFVG", "length": 123 }, "evidence": [ { "id": "Q5E9C2", "url": "https://omabrowser.org/oma/group/Q5E9C2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P61803-1", "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "gene_name": "DAD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSASVVSVISRFLEEYLSSTPQRLKLLDAYLLYILLTGALQFGYCLLVGTFPFNSFLSGFISCVGSFILAVCLRIQINPQNKADFQGISPERAFADFLFASTILHLVVMNFVG", "length": 113 }, "evidence": [ { "id": "Q5E9C2", "url": "https://omabrowser.org/oma/group/Q5E9C2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P61804-1", "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "gene_name": "Dad1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSASVVSVISRFLEEYLSSTPQRLKLLDAYLLYILLTGALQFGYCLLVGTFPFNSFLSGFISCVGSFILAVCLRIQINPQNKADFQGISPERAFADFLFASTILHLVVMNFVG", "length": 113 }, "evidence": [ { "id": "Q5E9C2", "url": "https://omabrowser.org/oma/group/Q5E9C2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P61805-1", "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "gene_name": "Dad1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSASVVSVISRFLEEYLSSTPQRLKLLDAYLLYILLTGALQFGYCLLVGTFPFNSFLSGFISCVGSFILAVCLRIQINPQNKADFQGISPERAFADFLFASTILHLVVMNFVG", "length": 113 }, "evidence": [ { "id": "Q5E9C2", "url": "https://omabrowser.org/oma/group/Q5E9C2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q29036-1", "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "gene_name": "DAD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSASVLSVISRFLEEYLSSTPQRLKLLDAYLLYILLTGALQFGYCLLVGTFPFNSFLSGFISCVGSFILAVCLRIQINPQNKADFQGISPERAFADFLFASTILHLVVMNFVG", "length": 113 }, "evidence": [ { "id": "Q5E9C2", "url": "https://omabrowser.org/oma/group/Q5E9C2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q39080-1", "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "gene_name": "DAD1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVKSTSKDAQDLFRSLRSAYSATPTNLKIIDLYVVFAVFTALIQVVYMALVGSFPFNSFLSGVLSCIGTAVLAVCLRIQVNKENKEFKDLAPERAFADFVLCNLVLHLVIINFLG", "length": 115 }, "evidence": [ { "id": "Q5E9C2", "url": "https://omabrowser.org/oma/group/Q5E9C2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q54FB6-1", "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2", "gene_name": "ost2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSTTASTSSNNLTFTSIVKSFFESYSKTPQKLKIIDLFLIYTFITGVIVFTYCCLVGTYPFNSFLAAFISTVGCFVLTVCLRIQINPINNFGKTISIERAFTDYLLCNLILHLVVFNFLG", "length": 120 }, "evidence": [ { "id": "Q5E9C2", "url": "https://omabrowser.org/oma/group/Q5E9C2/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9VLM5-1", "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "gene_name": "Dad1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVELSSVISKFYNDYVQNTPKKLKLVDIYLGYILLTGIIQFVYCCLVGTFPFNSFLSGFISTVSCFVLAVCLRLQANPQNKSVFAGISPERGFADFIFAHVILHLVVMNFIG", "length": 112 }, "evidence": [ { "id": "Q5E9C2", "url": "https://omabrowser.org/oma/group/Q5E9C2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "enzyme activator activity", "id": "GO:0008047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008047", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C2", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C2", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2" } ], "pmid": "" }, { "name": "glycoprotein biosynthetic process", "id": "GO:0009101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009101", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C2", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2" } ], "pmid": "" }, { "name": "regulation of protein stability", "id": "GO:0031647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C2", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2" } ], "pmid": "" }, { "name": "protein N-linked glycosylation", "id": "GO:0006487", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006487", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C2", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "oligosaccharyltransferase complex", "id": "GO:0008250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008250", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C2", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2" } ], "pmid": "" }, { "name": "oligosaccharyltransferase complex A", "id": "GO:0160226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160226", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C2", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2" } ], "pmid": "" }, { "name": "oligosaccharyltransferase complex B", "id": "GO:0160227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160227", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C2", "url": "https://www.uniprot.org/uniprotkb/Q5E9C2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9C2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 113, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9C2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9C2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9Y6-1", "uniprot_ac": "Q5E9Y6", "uniprot_id": "PRUN1_BOVIN", "mass": { "chemical_mass": 50080.0, "monoisotopic_mass": 50080.0 }, "refseq": { "ac": "NP_001030429", "name": "exopolyphosphatase PRUNE1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030429" }, "gene_names": [ { "name": "PRUNE1", "type": "recommended", "evidence": [ { "id": "Q5E9Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6" } ] }, { "name": "PRUNE1", "type": "synonym", "evidence": [ { "id": "NP_001030429", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030429" } ] }, { "name": "PRUNE", "type": "synonym", "evidence": [ { "id": "NP_001030429", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030429" }, { "id": "Q5E9Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6" } ] } ], "protein_names": [ { "name": "Exopolyphosphatase PRUNE1", "type": "recommended", "evidence": [ { "id": "Q5E9Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6/entry#names_and_taxonomy" } ] }, { "name": "3.6.1.14", "type": "synonym", "evidence": [ { "id": "Q5E9Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6/entry#names_and_taxonomy" } ] }, { "name": "3.6.1.25", "type": "synonym", "evidence": [ { "id": "Q5E9Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6/entry#names_and_taxonomy" } ] }, { "name": "exopolyphosphatase PRUNE1", "type": "synonym", "evidence": [ { "id": "NP_001030429", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030429" } ] }, { "name": "protein prune homolog", "type": "synonym", "evidence": [ { "id": "NP_001030429", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030429" } ] } ], "function": [ { "annotation": "Exopolyphosphatase that catalyzes the hydrolysis of inorganic polyphosphates, with preference for short-chain substrates, as well as nucleoside 5'-tetraphosphates, releasing terminal phosphate residues. Also exhibits phosphodiesterase activity toward cyclic nucleotides, hydrolyzing cAMP and cGMP to their corresponding 5'-monophosphates. Requires divalent metal ions for activity. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Y6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6#function" }, { "database": "UniProtKB", "id": "Q86TP1", "url": "https://www.uniprot.org/uniprotkb/Q86TP1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9Y6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRUNE1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6", "locus": { "chromosome": "3", "start_pos": 19746347, "end_pos": 19766299, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015336", "url": "https://www.ensembl.org/id/ENSBTAG00000015336" } ] } } ], "crossref": [ { "id": "Q5E9Y6", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9Y6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015336", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015336", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "524973", "url": "https://www.ncbi.nlm.nih.gov/gene/524973", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001667", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001667", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524973", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524973", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TMTIFFN", "url": "https://omabrowser.org/oma/group/TMTIFFN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LJH2", "url": "https://www.orthodb.org/?gene=A0A3Q1LJH2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LY96", "url": "https://www.orthodb.org/?gene=A0A3Q1LY96", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5E9Y6", "url": "https://www.orthodb.org/?gene=Q5E9Y6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12112", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12112", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12112:SF47", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12112:SF47", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01368", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01368", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02833", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02833", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030429", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "14157", "url": "https://www.rhea-db.org/rhea/14157", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "16957", "url": "https://www.rhea-db.org/rhea/16957", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "24500", "url": "https://www.rhea-db.org/rhea/24500", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "24576", "url": "https://www.rhea-db.org/rhea/24576", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "25277", "url": "https://www.rhea-db.org/rhea/25277", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LJH2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJH2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LY96", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LY96-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH02", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1D5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1D5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z1D5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z1D5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9Y6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9Y6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MENYLQGCRAALQESRPIHVVLGNEACDLDSMVSALALAFYLAKTTEAEEVFVPVLNIKRSELPLRGDNVFFLQKIHIPESVLIFRDEIDLHALHQAGQLTLILVDHHVLPKSDAALEEAVAEVLDHRPIDQRHCPPCHVSVELVGSCATLVAERILQGAPEILDRQTAALLHGTILLDCVNMDLKIGKATLKDSHYVEKLEALFPDLPSRNDIFDSLQKAKFDVSGLTTEQMLRKDQKTISRQGTKVAISAIYMDMEAFLQRSGLLADLRAFCQAHSYDALVAMTIFFNTYNEPVRQLAVFCPHAALRMTICGILEHSHSPPLKLTPVPSSHPDLQAYLQGNTQISRKKVLPLLQEALSAYFDSTNIPLGQPETEGVSREQVDKELDRAGNSLLSGLSQDEEEPPLPPTPMNSLVDECPLDQGLPKFSAEVIFEKCSQISLSEPTTASLSKK", "length": 453, "header": "sp|Q5E9Y6-1|PRUN1_BOVIN Isoform 1 of Exopolyphosphatase PRUNE1 OS=Bos taurus OX=9913 GN=PRUNE1 PE=2 SV=1 CANONICAL=Q5E9Y6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJH2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6/entry#A0A3Q1LJH2-1", "sequence": { "sequence": "MKPVGLHPGNAEGVEEAAGSGESAASRKLAEHAGDPISLWSGPCYPQRPQLLIHHFLSIPSLESRPIHVVLGNEACDLDSMVSALALAFYLAKTTEAEEVFVPVLNIKRSELPLRGDNVFFLQKIHIPESVLIFRDEIDLHALHQAGQLTLILVDHHVLPKSDAALEEAVAEVLDHRPIDQRHCPPCHVSVELVGSCATLVAERILQGAPEILDRQTAALLHGTILLDCVNMDLKIGKATLKDSHYVEKLEALFPDLPSRNDIFDSLQKAKFDVSGLTTEQMLRKDQKTISRQGTKVAISAIYMDMEAFLQRSGLLADLRAFCQAHSYDALVAMTIFFNTYNEPVRQLAVFCPHAALRMTICGILEHSHSPPLKLTPVPSSHPDLQAYLQGNTQISRKKVLPLLQEALSAYFDSTNIPLGQPETEGVSREQVDKELDRAGNSLLSGLSQDEEEPPLPPTPMNSLVDECPLDQGLPKFSAEVIFEKCSQISLSEPTTASLSKK", "length": 502, "header": "tr|A0A3Q1LJH2-1|PRUN1_BOVIN Computationally mapped isoform of Exopolyphosphatase PRUNE1 OS=Bos taurus OX=9913 GN=PRUNE1 PE=2 SV=2 CANONICAL=Q5E9Y6-1" }, "locus": { "chromosome": "3", "start_pos": 19765885, "end_pos": 19747781, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067708.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067708.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056671.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056671.2" } ] } }, { "isoform_ac": "A0A3Q1LY96-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6/entry#A0A3Q1LY96-1", "sequence": { "sequence": "MQNYKESRPIHVVLGNEACDLDSMVSALALAFYLAKTTEAEEVFVPVLNIKRSELPLRGDNVFFLQKIHIPESVLIFRDEIDLHALHQAGQLTLILVDHHVLPKSDAALEEAVAEVLDHRPIDQRHCPPCHVSVELVGSCATLVAERILQGAPEILDRQTAALLHGTILLDCVNMDLKIGKATLKDSHYVEKLEALFPDLPSRNDIFDSLQKAKFDVSGLTTEQMLRKDQKTISRQGTKVAISAIYMDMEAFLQRSGLLADLRAFCQAHSYDALVAMTIFFNTYNEPVRQLAVFCPHAALRMTICGILEHSHSPPLKLTPVPSSHPDLQAYLQGNTQISRKKVLPLLQEALSAYFDSTNIPLGQPETEGVSREQVDKELDRAGNSLLSGLSQDEEEPPLPPTPMNSLVDECPLDQGLPKFSAEVIFEKCSQISLSEPTTASLSKK", "length": 445, "header": "tr|A0A3Q1LY96-1|PRUN1_BOVIN Computationally mapped isoform of Exopolyphosphatase PRUNE1 OS=Bos taurus OX=9913 GN=PRUNE1 PE=2 SV=2 CANONICAL=Q5E9Y6-1" }, "locus": { "chromosome": "3", "start_pos": 19758660, "end_pos": 19747781, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078005.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078005.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062223.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062223.2" } ] } }, { "isoform_ac": "A0AAA9SH02-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6/entry#A0AAA9SH02-1", "sequence": { "sequence": "MENYLQGCRAALQESRPIHVVLGNEACDLDSMVSALALAFYLAKTTEAEEVFVPVLNIKRSELPLRGDNVFFLQKIHIPESVLIFRDEIDLHALHQAGQLTLILVDHHVLPKSDAALEEAVAEVLDHRPIDQRHCPPCHVSVELVGSCATLVAERILQGAPEILDRQTAALLHGTILLDCVNMDLKIGKATLKDSHYVEKLEALFPDLPSRNDIFDSLQKAKFDVSGLTTEQMLRKDQKTISRQGTKVAISAIYMDMEICGILEHSHSPPLKLTPVPSSHPDLQAYLQGNTQISRKKVLPLLQEALSAYFDSTNIPLGQPETEGVSREQVDKELDRAGNSLLSGLSQDEEEPPLPPTPMNSLVDECPLDQGLPKFSAEVIFEKCSQISLSEPTTASLSKK", "length": 400, "header": "tr|A0AAA9SH02-1|PRUN1_BOVIN Computationally mapped isoform of Exopolyphosphatase PRUNE1 OS=Bos taurus OX=9913 GN=PRUNE1 PE=2 SV=1 CANONICAL=Q5E9Y6-1" }, "locus": { "chromosome": "3", "start_pos": 19764768, "end_pos": 19747781, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103669.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103669.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085481.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085481.1" } ] } }, { "isoform_ac": "A0AAF6Z1D5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6/entry#A0AAF6Z1D5-1", "sequence": { "sequence": "MDPGVQERRRCGIWGAPKESRPIHVVLGNEACDLDSMVSALALAFYLAKTTEAEEVFVPVLNIKRSELPLRGDNVFFLQKIHIPESVLIFRDEIDLHALHQAGQLTLILVDHHVLPKSDAALEEAVAEVLDHRPIDQRHCPPCHVSVELVGSCATLVAERILQGAPEILDRQTAALLHGTILLDCVNMDLKIGKATLKDSHYVEKLEALFPDLPSRNDIFDSLQKAKFDVSGLTTEQMLRKDQKTISRQGTKVAISAIYMDMEAFLQRSGLLADLRAFCQAHSYDALVAMTIFFNTYNEPVRQLAVFCPHAALRMTICGILEHSHSPPLKLTPVPSSHPDLQAYLQGNTQISRKKVLPLLQEALSAYFDSTNIPLGQPETEGVSREQVDKELDRAGNSLLSGLSQDEEEPPLPPTPMNSLVDECPLDQGLPKFSAEVIFEKCSQISLSEPTTASLSKK", "length": 458, "header": "tr|A0AAF6Z1D5-1|PRUN1_BOVIN Computationally mapped isoform of Exopolyphosphatase PRUNE1 OS=Bos taurus OX=9913 GN=PRUNE1 PE=2 SV=1 CANONICAL=Q5E9Y6-1" }, "locus": { "chromosome": "3", "start_pos": 19764699, "end_pos": 19747781, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020388.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020388.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020388.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020388.5" } ] } }, { "isoform_ac": "Q5E9Y6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6/entry#Q5E9Y6-1", "sequence": { "sequence": "MENYLQGCRAALQESRPIHVVLGNEACDLDSMVSALALAFYLAKTTEAEEVFVPVLNIKRSELPLRGDNVFFLQKIHIPESVLIFRDEIDLHALHQAGQLTLILVDHHVLPKSDAALEEAVAEVLDHRPIDQRHCPPCHVSVELVGSCATLVAERILQGAPEILDRQTAALLHGTILLDCVNMDLKIGKATLKDSHYVEKLEALFPDLPSRNDIFDSLQKAKFDVSGLTTEQMLRKDQKTISRQGTKVAISAIYMDMEAFLQRSGLLADLRAFCQAHSYDALVAMTIFFNTYNEPVRQLAVFCPHAALRMTICGILEHSHSPPLKLTPVPSSHPDLQAYLQGNTQISRKKVLPLLQEALSAYFDSTNIPLGQPETEGVSREQVDKELDRAGNSLLSGLSQDEEEPPLPPTPMNSLVDECPLDQGLPKFSAEVIFEKCSQISLSEPTTASLSKK", "length": 453, "header": "sp|Q5E9Y6-1|PRUN1_BOVIN Isoform 1 of Exopolyphosphatase PRUNE1 OS=Bos taurus OX=9913 GN=PRUNE1 PE=2 SV=1 CANONICAL=Q5E9Y6-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 410, "start_aa": "Thr", "end_pos": 410, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr410", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 399, "end_pos": 399, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Y6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6" } ], "site_lbl": "Ser399" }, { "start_pos": 410, "end_pos": 410, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Y6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6" } ], "site_lbl": "Thr410" }, { "start_pos": 414, "end_pos": 414, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Y6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6" } ], "site_lbl": "Ser414" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Y6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:524973", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524973", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1SDE2-1", "protein_name": "Exopolyphosphatase PRUNE1", "gene_name": "PRUNE1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEDYLQGCRAALQESRPLHVVLGNEACDLDSMVSALALAFYLAKTTEAEEVFVPVLNIKRSELPLRGDNVFFLQKIHIPESLLIFRDEIDLHALHQAGQLTLILVDHHVLPKTDAALEEAVAEVLDHRPIDQKHCPPCHVSVELVGSCATLVTERILQGAPEILDLQIAALLHGTIILDCVNMDLKIGKATPKDNKYVEKLEALFPDLPNRNDIFDSLQKAKFDVSGLTTEQMLRKDQKTISRQGIKVAISAIYMDLEAFLQRSGLIADLHAFCQAHSYDALVAMTIFFNTHNEPVRQLAVFCPHTALRVMICGVLESSHSPSLKLVPVPSTHPNLQAYLQGNTQVSRKKLLPLLQEALSAYFDSMKSPSGQPETAGVSREQVDKELDRAGNSLISGLSQDEEEPPLPPTPMNSLVDECPLDQGLPKFSAEVIFEKCSQISLSESTTASLSKK", "length": 453 }, "evidence": [ { "id": "Q5E9Y6", "url": "https://omabrowser.org/oma/group/Q5E9Y6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V1A9L3-1", "protein_name": "Prune exopolyphosphatase 1", "gene_name": "PRUNE1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MERFLGGRRAALQEHIQRRQEVHVVMGNEACDLDSTVSALALAYFLAKTSVPPKAAFIPVLNIPRADFALRTETTFLLREHSIPDSSLIFRDEIDLAGLHRAGLLSLTLVDHHVLPSTDAALEEAVVDVLDHRPLEREWAPSCQLTVELVGSCATLVTERIAQGPPGVLDRTTAALLHGTILLDSVNLSPAAGKVTPRDVLCVSLLESRFPELPPHDSIYGALQAAKFDVSGLTTEQMLRKDLKTVSGDEQVLAISGVYMDIELFLRRPGLLQDLETFCQTRGYSVLVAMTVSFNDCYEPTRQLAVYSQHEALRSTVCRALEEATTPALHLQALPSPWPCISAYAQGNTLASRKKVLPILRAALGGGPGTAAGPEEEAAPPPTPMNSLVEESPLAQAVPPVCPQAVLERVSRMAAEQPDSDK", "length": 422 }, "evidence": [ { "id": "Q5E9Y6", "url": "https://omabrowser.org/oma/group/Q5E9Y6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3H2Y2-1", "protein_name": "Exopolyphosphatase PRUNE1", "gene_name": "Prune1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEDYLQDCRAALQESRPLHVVLGNEACDLDSMVSALALAFYLTKTSESGEIFIPVLNINRSELPLRGDNVFFLQKVRIPEPVLIFRDEIDLHALHQAGQLTLTLVDHHVLPKSDAALEEAVAEVLDHRPIEQKYCPPCHVSVEHVGSCATLVAERILQGAPEILDRQTAFLLYGTIILDCVNMDAKVGKATLKDSKYVEKLEALFPDLPQREDIFDSLQKAKFDVSGLTTEQMLRKDQKTVCRQDTKVAISAVYMDLEAFLQRLDLLEDLSAFCHEHSYDALVAMTIFFNTHNEPVRQLAVFCPHSALRMTICGVLEQSTSPPLKLTPIPSISPDLQAYLQGNTQVSRKKLLPVLQEALSAYFDSTKMPSGQLGVVGMSREQGDKELDRAGSSIFGLSQDEEDPPLPPTPMNSLVDECPLDQGLPKLSAEAVFEKCSQISLSQSTRACPSNK", "length": 452 }, "evidence": [ { "id": "Q5E9Y6", "url": "https://omabrowser.org/oma/group/Q5E9Y6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P38698-1", "protein_name": "Polyphosphatase", "gene_name": "PPX1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSPLRKTVPEFLAHLKSLPISKIASNDVLTICVGNESADMDSIASAITYSYCQYIYNEGTYSEEKKKGSFIVPIIDIPREDLSLRRDVMYVLEKLKIKEEELFFIEDLKSLKQNVSQGTELNSYLVDNNDTPKNLKNYIDNVVGIIDHHFDLQKHLDAEPRIVKVSGSCSSLVFNYWYEKLQGDREVVMNIAPLLMGAILIDTSNMRRKVEESDKLAIERCQAVLSGAVNEVSAQGLEDSSEFYKEIKSRKNDIKGFSVSDILKKDYKQFNFQGKGHKGLEIGLSSIVKRMSWLFNEHGGEADFVNQCRRFQAERGLDVLVLLTSWRKAGDSHRELVILGDSNVVRELIERVSDKLQLQLFGGNLDGGVAMFKQLNVEATRKQVVPYLEEAYSNLEE", "length": 397 }, "evidence": [ { "id": "Q5E9Y6", "url": "https://omabrowser.org/oma/group/Q5E9Y6/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q6AYG3-1", "protein_name": "Exopolyphosphatase PRUNE1", "gene_name": "Prune1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEDYLQDCRAALQESRPLHVVLGNEACDLDSMVSALALAFYLTKTSEAEDIFIPVLNIKRSELPLRGDNVFFLQEVKIAESALIFRDEIDLLALHQAGQLTLILVDHHMLPKSDAALEEAVAEVLDHRPIEQKYCPPCHVSVELVGSCATLVAERILQGAPETLDRQTAALLHGTIILDCVNMDAKIGKATLKDNEYVEKLEALFPDLPKRKDIFDSLQKAKFDVSGLTTEQMLRKDQKTIYRQGTKVAVSAVYMDLEAFLQRSGLLSDLSAFCQDHSYDALVAMAIFFNTHNEPVRQLAIFCPHEALRMTICGVLEQSTSPALKLTPIPSISAHLQAYLQGNTQVSRKKLLPVLQEALSAYLDSMRTPAGQLEAALGMSREQADKELDKASNSLIAGLSQDDEDPPLPPTPMNSLVDECPLDQGLPKLSAEAVFEKCSQISLSQSTRACPSNK", "length": 454 }, "evidence": [ { "id": "Q5E9Y6", "url": "https://omabrowser.org/oma/group/Q5E9Y6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86TP1-1", "protein_name": "Exopolyphosphatase PRUNE1", "gene_name": "PRUNE1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEDYLQGCRAALQESRPLHVVLGNEACDLDSTVSALALAFYLAKTTEAEEVFVPVLNIKRSELPLRGDIVFFLQKVHIPESILIFRDEIDLHALYQAGQLTLILVDHHILSKSDTALEEAVAEVLDHRPIEPKHCPPCHVSVELVGSCATLVTERILQGAPEILDRQTAALLHGTIILDCVNMDLKIGKATPKDSKYVEKLEALFPDLPKRNDIFDSLQKAKFDVSGLTTEQMLRKDQKTIYRQGVKVAISAIYMDLEAFLQRSNLLADLHAFCQAHSYDVLVAMTIFFNTHNEPVRQLAIFCPHVALQTTICEVLERSHSPPLKLTPASSTHPNLHAYLQGNTQVSRKKLLPLLQEALSAYFDSMKIPSGQPETADVSREQVDKELDRASNSLISGLSQDEEDPPLPPTPMNSLVDECPLDQGLPKLSAEAVFEKCSQISLSQSTTASLSKK", "length": 453 }, "evidence": [ { "id": "Q5E9Y6", "url": "https://omabrowser.org/oma/group/Q5E9Y6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BIW1-1", "protein_name": "Exopolyphosphatase PRUNE1", "gene_name": "Prune1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEDYLQDCRAALQDSRPLHVVLGNEACDLDSMVSALALAFYLTKTSEAEDIFIPVLNIKRSELPLRGDNVFFLQEVKIPEPALIFRDEIDLLALHQAGQLTLILVDHHILPKSDAALEEAVAEVLDHRPIEQKYCPPCHVSVELVGSCATLVTERILQGAPETLDRQTAALLHGTIILDCVNMDTNIGKATPKDSKYVEELEALFPDLPKRKDIFDSLQKAKFDVSGLTTEQMLRKDQKTVYRQGTKVAISAIYMDLKAFLQRTDLFTDLSSFCHDHSYDALVAMTIFFNTQNEPVRQLAIFCPHEALRMTICGILERSTSPPLKLTPIPSTSPNLQAYHQGNTQVSRKKLLPVLQEALSAYLDSAKMASGQSEVAVGMSREQVDKDLDKASNSLISGLSQDEEDPPLPPTPMNSLVDECPLDQGLPKFSAEAVFEKCSQISLSQSARACTSNK", "length": 454 }, "evidence": [ { "id": "Q5E9Y6", "url": "https://omabrowser.org/oma/group/Q5E9Y6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Y6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Y6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Y6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Y6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Y6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6" } ], "pmid": "" }, { "name": "inorganic diphosphate phosphatase activity", "id": "GO:0004427", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004427", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Y6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6" } ], "pmid": "" }, { "name": "exopolyphosphatase activity", "id": "GO:0004309", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004309", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Y6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6" } ], "pmid": "" }, { "name": "tubulin binding", "id": "GO:0015631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015631", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Y6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6" } ], "pmid": "" }, { "name": "phosphatase activity", "id": "GO:0016791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016791", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Y6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6" } ], "pmid": "" }, { "name": "pyrophosphatase activity", "id": "GO:0016462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016462", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Y6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of microtubule polymerization", "id": "GO:0031113", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031113", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Y6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6" } ], "pmid": "" }, { "name": "regulation of neurogenesis", "id": "GO:0050767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050767", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Y6", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "14157", "name": "", "equation": "triphosphate + H2O = phosphate + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9Y6-1" ], "evidence": [ { "id": "14157", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14157" } ] }, { "id": "16957", "name": "", "equation": "3',5'-cyclic GMP + H2O = GMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9TY04-1", "P16586-1", "P14099-1", "P14100-1", "P11541-1", "P23439-1", "Q01061-1", "Q28156-1", "A0A3Q1N4S8-1", "P22571-1", "A0A3Q1M1E8-1", "E1BN64-1", "A0A3Q1MJ90-1", "E1BPD8-1", "F1MH30-1", "A0A3Q1MHJ4-1", "Q5E9Y6-1" ], "evidence": [ { "id": "16957", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16957" } ] }, { "id": "24500", "name": "", "equation": "adenosine 5'-tetraphosphate + H2O = phosphate + ATP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9Y6-1" ], "evidence": [ { "id": "24500", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24500" } ] }, { "id": "24576", "name": "", "equation": "diphosphate + H2O = 2 phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P09487-1", "P37980-1", "Q0VD18-1", "Q5E9Y6-1" ], "evidence": [ { "id": "24576", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24576" } ] }, { "id": "25277", "name": "", "equation": "3',5'-cyclic AMP + H2O = AMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9TY04-1", "A0AAA9S3N4-1", "P14099-1", "P14100-1", "Q01061-1", "F1MBI5-1", "A0A3Q1N4S8-1", "F1N5T6-1", "A0A3Q1M1E8-1", "E1BN64-1", "F6R930-1", "A0A3Q1MJ90-1", "A0A3Q1M5L1-1", "E1BPD8-1", "A0AAA9T4P8-1", "F1MNS5-1", "A0A3Q1MHJ4-1", "Q5E9Y6-1" ], "evidence": [ { "id": "25277", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/25277" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M1E8", "gene_name": "PDE3A", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "A0A3Q1M1E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1E8" } ] } ] }, { "uniprot_ac": "A0A3Q1M5L1", "gene_name": "PDE8B", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "A0A3Q1M5L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5L1" } ] } ] }, { "uniprot_ac": "A0A3Q1MHJ4", "gene_name": "PDE10A", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "A0A3Q1MHJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHJ4" } ] } ] }, { "uniprot_ac": "A0A3Q1MJ90", "gene_name": "PDE2A", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "A0A3Q1MJ90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJ90" } ] } ] }, { "uniprot_ac": "A0A3Q1N4S8", "gene_name": "PDE1C", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "A0A3Q1N4S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4S8" } ] } ] }, { "uniprot_ac": "A0AAA9S3N4", "gene_name": "PDE4D", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "A0AAA9S3N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3N4" } ] } ] }, { "uniprot_ac": "A0AAA9T4P8", "gene_name": "PDE7A", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "A0AAA9T4P8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4P8" } ] } ] }, { "uniprot_ac": "A0AAA9TY04", "gene_name": "PDE1A", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "A0AAA9TY04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY04" } ] } ] }, { "uniprot_ac": "E1BN64", "gene_name": "PDE3B", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": 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"sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "A6QPF8-1", "uniprot_ac": "A6QPF8", "uniprot_id": "T120B_BOVIN", "mass": { "chemical_mass": 40373.0, "monoisotopic_mass": 40373.0 }, "refseq": { "ac": "NP_001095378", "name": "transmembrane protein 120B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095378" }, "gene_names": [ { "name": "TMEM120B", "type": "recommended", "evidence": [ { "id": "A6QPF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QPF8" } ] }, { "name": "TMEM120B", "type": "synonym", "evidence": [ { "id": "NP_001095378", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095378" } ] } ], "protein_names": [ { "name": "Transmembrane protein 120B", "type": "recommended", "evidence": [ { "id": "A6QPF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QPF8/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 120B", "type": "synonym", "evidence": [ { "id": "NP_001095378", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095378" } ] } ], "function": [ { "annotation": "Necessary for efficient adipogenesis. Does not show ion channel activity.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2N7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2N7#function" }, { "database": "UniProtKB", "id": "ARBA00045162", "url": "https://www.uniprot.org/uniprotkb/ARBA00045162#function" }, { "database": "UniProtKB", "id": "A6QPF8", "url": "https://www.uniprot.org/uniprotkb/A6QPF8#function" }, { "database": "UniProtKB", "id": "Q3TA38", "url": "https://www.uniprot.org/uniprotkb/Q3TA38#function" }, { "database": "UniProtKB", "id": "A0A3Q1M1U3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1U3#function" }, { "database": "UniProtKB", "id": "A0A3Q1LNZ8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNZ8#function" }, { "database": "UniProtKB", "id": "A0AAA9SLK4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK4#function" }, { "database": "UniProtKB", "id": "A0AAF6YU52", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU52#function" }, { "database": "UniProtKB", "id": "A0AAA9SBD7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD7#function" }, { "database": "UniProtKB", "id": "A0AAA9TJ91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ91#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QPF8", "url": "https://www.uniprot.org/uniprotkb/A6QPF8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM120B", "url": "https://www.uniprot.org/uniprotkb/A6QPF8", "locus": { "chromosome": "17", "start_pos": 53521528, "end_pos": 53567555, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009602", "url": "https://www.ensembl.org/id/ENSBTAG00000009602" } ] } } ], "crossref": [ { "id": "A6QPF8", "url": "https://alphafold.ebi.ac.uk/entry/A6QPF8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009602", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009602", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508790", "url": "https://www.ncbi.nlm.nih.gov/gene/508790", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508790", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508790", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WPNTGPW", "url": "https://omabrowser.org/oma/group/WPNTGPW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LNZ8", "url": "https://www.orthodb.org/?gene=A0A3Q1LNZ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M1U3", "url": "https://www.orthodb.org/?gene=A0A3Q1M1U3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M2N7", "url": "https://www.orthodb.org/?gene=A0A3Q1M2N7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A6QPF8", "url": "https://www.orthodb.org/?gene=A6QPF8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21433", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21433", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21433:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21433:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07851", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07851", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095378", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LNZ8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LNZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1U3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1U3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1U3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1U3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2N7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2N7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2N7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2N7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBD7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBD7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLK4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLK4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLK4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YU52", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YU52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU52-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QPF8", "url": "https://www.uniprot.org/uniprotkb/A6QPF8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QPF8-1", "url": "https://www.uniprot.org/uniprotkb/A6QPF8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGQLERCEREWHELEGEFQELQETHRIYKQKLEELNALQTSCSSSINKQKTRLKDLKLTLQRYKRHASREEAELVQQMGANIKERQNVFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEKFKLYLTIILLLGAVACRFFLHYRVTDEVFNFLLVWYYCTLTIRESILISNGSRIKGWWVSHHYVSTFLSGVMLTWPNGLIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALGERNHLDLTVEGFQSWMWRGLTFLLPFLFCGHFWQLYNAVTLFELSSHEECREWQVFVLALTFLVLFLGNFLTTLKVVHTKLQQNRSKAKKP", "length": 339, "header": "sp|A6QPF8-1|T120B_BOVIN Isoform 1 of Transmembrane protein 120B OS=Bos taurus OX=9913 GN=TMEM120B PE=2 SV=1 CANONICAL=A6QPF8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LNZ8-1", "url": "https://www.uniprot.org/uniprotkb/A6QPF8/entry#A0A3Q1LNZ8-1", "sequence": { "sequence": "MSGQLERCEREWHELEGEFQELQETHRIYKQKLEELNALQTSCSSSINKQKTRLKDLKLTLQRYKRHASREEAELVQQMGANIKERQNVFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEKFKLYLTIILLLGAVACRFFLHYRVTDEVFNFLLVWYYCTLTIRESILISNGSRIKGWWVSHHYVSTFLSGVMLTWPNGLIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALGERNHLDLTVEGFQSWMWRGLTFLLPFLFCGHLCTPNSSRTEARPRSREPWGQRPSRPRTLRLQGIPGGVLAAHLLPNSASDHWQR", "length": 333, "header": "tr|A0A3Q1LNZ8-1|T120B_BOVIN Computationally mapped isoform of Transmembrane protein 120B OS=Bos taurus OX=9913 GN=TMEM120B PE=2 SV=2 CANONICAL=A6QPF8-1" }, "locus": { "chromosome": "17", "start_pos": 53567417, "end_pos": 53524953, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077158.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077158.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058591.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058591.2" } ] } }, { "isoform_ac": "A0A3Q1M1U3-1", "url": "https://www.uniprot.org/uniprotkb/A6QPF8/entry#A0A3Q1M1U3-1", "sequence": { "sequence": "MSGQLERCEREWHELEGEFQELQETHRIYKQKLEELNALQTSCSSSINKQKTRLKDLKLTLQRYKRHASREEAELVQQMGANIKERQNVFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEKFKLYLTIILLLGAVACRFFLHYRVTDEVFNFLLVWYYCTLTIRESILISNGSRIKGWWVSHHYVSTFLSGVMLTWPNGLIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALGERNHLDLTVEGFQSWMWRGLTFLLPFLFCGHFWQLYNAVTLFELSSHEECREWQVFVLALTFLVLFLGNFLTTLKVVHTKLQQNRSKAKKPHGLGGPVGCAERKHTAGSWM", "length": 359, "header": "tr|A0A3Q1M1U3-1|T120B_BOVIN Computationally mapped isoform of Transmembrane protein 120B OS=Bos taurus OX=9913 GN=TMEM120B PE=2 SV=2 CANONICAL=A6QPF8-1" }, "locus": { "chromosome": "17", "start_pos": 53567417, "end_pos": 53522442, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077836.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077836.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062036.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062036.2" } ] } }, { "isoform_ac": "A0A3Q1M2N7-1", "url": "https://www.uniprot.org/uniprotkb/A6QPF8/entry#A0A3Q1M2N7-1", "sequence": { "sequence": "MSGQLERCEREWHELEGEFQELQETHRIYKQKLEELNALQTSCSSSINKQKTRLKDLKLTLQRYKRHASREEAELVQQMGANIKERQNVFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEKFKLYLTIILLLGAVACRFFLHYRVTDEVFNFLLVWYYCTLTIRESILISNGSRLGSLPFSPLLSSFPSLLSRIKGWWVSHHYVSTFLSGVMLTWPNGLIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALGERNHLDLTVEGFQSWMWRGLTFLLPFLFCGHFWQLYNAVTLFELSSHEECREWQVFVLALTFLVLFLGNFLTTLKVVHTKLQQNRSKAKKP", "length": 358, "header": "tr|A0A3Q1M2N7-1|T120B_BOVIN Computationally mapped isoform of Transmembrane protein 120B OS=Bos taurus OX=9913 GN=TMEM120B PE=2 SV=2 CANONICAL=A6QPF8-1" }, "locus": { "chromosome": "17", "start_pos": 53567417, "end_pos": 53525068, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072105.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072105.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064072.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064072.2" } ] } }, { "isoform_ac": "A0AAA9SBD7-1", "url": "https://www.uniprot.org/uniprotkb/A6QPF8/entry#A0AAA9SBD7-1", "sequence": { "sequence": "MSGQLERCEREWHELEGEFQELQETHRIYKQKLEELNALQTSCSSSINKQKTRLKDLKLTLQRYKRHASREEAELVQQMGANIKERQNVFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKVTDEVFNFLLVWYYCTLTIRESILISNGSRIKGWWVSHHYVSTFLSGVMLTWPNGLIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALGERNHLDLTVEGFQSWMWRGLTFLLPFLFCGHFWQLYNAVTLFELSSHEECREWQVFVLALTFLVLFLGNFLTTLKVVHTKLQQNRSKAKKP", "length": 307, "header": "tr|A0AAA9SBD7-1|T120B_BOVIN Computationally mapped isoform of Transmembrane protein 120B OS=Bos taurus OX=9913 GN=TMEM120B PE=2 SV=1 CANONICAL=A6QPF8-1" }, "locus": { "chromosome": "17", "start_pos": 53567417, "end_pos": 53525068, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098745.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098745.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083406.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083406.1" } ] } }, { "isoform_ac": "A0AAA9SLK4-1", "url": "https://www.uniprot.org/uniprotkb/A6QPF8/entry#A0AAA9SLK4-1", "sequence": { "sequence": "MSGQLERCEREWHELEGEFQELQETHRIYKQKLEELNALQTSCSSSINKQKTRLKDLKLTLQRYKRHASREEAELVQQMGANIKERQNVFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEKFKLYLTIILLLGAVACRFFLHYRIKGWWVSHHYVSTFLSGVMLTWPNGLIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALGERNHLDLTVEGFQSWMWRGLTFLLPFLFCGHFWQLYNAVTLFELSSHEECREWQVFVLALTFLVLFLGNFLTTLKVVHTKLQQNRSKAKKP", "length": 309, "header": "tr|A0AAA9SLK4-1|T120B_BOVIN Computationally mapped isoform of Transmembrane protein 120B OS=Bos taurus OX=9913 GN=TMEM120B PE=2 SV=1 CANONICAL=A6QPF8-1" }, "locus": { "chromosome": "17", "start_pos": 53567417, "end_pos": 53525068, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107130.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107130.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083527.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083527.1" } ] } }, { "isoform_ac": "A0AAA9TJ91-1", "url": "https://www.uniprot.org/uniprotkb/A6QPF8/entry#A0AAA9TJ91-1", "sequence": { "sequence": "MSGQLERCEREWHELEGEFQELQETHRIYKQKLEELNALQTSCSSSINKQKTRLKDLKLTLQRYKRHASREEAELVQQMGANIKERQNVFFDMEAYLPKKNGFAYKDEYEKFKLYLTIILLLGAVACRFFLHYRVTDEVFNFLLVWYYCTLTIRESILISNGSRIKGWWVSHHYVSTFLSGVMLTWPNGLIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALGERNHLDLTVEGFQSWMWRGLTFLLPFLFCGHFWQLYNAVTLFELSSHEECREWQVFVLALTFLVLFLGNFLTTLKVVHTKLQQNRSKAKKP", "length": 319, "header": "tr|A0AAA9TJ91-1|T120B_BOVIN Computationally mapped isoform of Transmembrane protein 120B OS=Bos taurus OX=9913 GN=TMEM120B PE=2 SV=1 CANONICAL=A6QPF8-1" }, "locus": { "chromosome": "17", "start_pos": 53567417, "end_pos": 53525068, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098261.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098261.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098399.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098399.1" } ] } }, { "isoform_ac": "A0AAF6YU52-1", "url": "https://www.uniprot.org/uniprotkb/A6QPF8/entry#A0AAF6YU52-1", "sequence": { "sequence": "METHRIYKQKLEELNALQTSCSSSINKQKTRLKDLKLTLQRYKRHASREEAELVQQMGANIKERQNVFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEKFKLYLTIILLLGAVACRFFLHYRVTDEVFNFLLVWYYCTLTIRESILISNGSRIKGWWVSHHYVSTFLSGVMLTWPNGLIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALGERNHLDLTVEGFQSWMWRGLTFLLPFLFCGHFWQLYNAVTLFELSSHEECREWQVFVLALTFLVLFLGNFLTTLKVVHTKLQQNRSKAKKP", "length": 317, "header": "tr|A0AAF6YU52-1|T120B_BOVIN Computationally mapped isoform of Transmembrane protein 120B OS=Bos taurus OX=9913 GN=TMEM120B PE=2 SV=1 CANONICAL=A6QPF8-1" }, "locus": { "chromosome": "17", "start_pos": 53553643, "end_pos": 53525068, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012636.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012636.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012636.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012636.5" } ] } }, { "isoform_ac": "A6QPF8-1", "url": "https://www.uniprot.org/uniprotkb/A6QPF8/entry#A6QPF8-1", "sequence": { "sequence": "MSGQLERCEREWHELEGEFQELQETHRIYKQKLEELNALQTSCSSSINKQKTRLKDLKLTLQRYKRHASREEAELVQQMGANIKERQNVFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEKFKLYLTIILLLGAVACRFFLHYRVTDEVFNFLLVWYYCTLTIRESILISNGSRIKGWWVSHHYVSTFLSGVMLTWPNGLIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALGERNHLDLTVEGFQSWMWRGLTFLLPFLFCGHFWQLYNAVTLFELSSHEECREWQVFVLALTFLVLFLGNFLTTLKVVHTKLQQNRSKAKKP", "length": 339, "header": "sp|A6QPF8-1|T120B_BOVIN Isoform 1 of Transmembrane protein 120B OS=Bos taurus OX=9913 GN=TMEM120B PE=2 SV=1 CANONICAL=A6QPF8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508790", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508790", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2UHS0-1", "protein_name": "Transmembrane protein 120B", "gene_name": "TMEM120B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRVQPERCCGEWRELDEEFRQLQETHKVYRQKLEEVTSLQTACSSSIHRQKKTLRDLKHSLQRCKPRATPEEFALIEQISTQIKERQNAFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEKFKLYLTIILLLGAVACRFILHYRVTDEVFNFLLVWYYCTLTIRESILISNGSRIKGWWVSHHYVSTFLSGVMLTWPDGLMYQMFRSQFLAFSIFQSCVQFLQYYYQRGCLYRLRALGERNHLDLTVEGFQSWMWRGLTFLLPFLFCGHFWQLYNAITLFGLSRHKECKEWQVCVLAFTFLLLFLGNFLTTLKVVHTKLQKNKDKMKKL", "length": 339 }, "evidence": [ { "id": "A6QPF8", "url": "https://omabrowser.org/oma/group/A6QPF8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0PK00-1", "protein_name": "Transmembrane protein 120B", "gene_name": "TMEM120B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGQLERCEREWHELEGEFQELQETHRIYKQKLEELAALQTLCSSSISKQKKHLKDLKLTLQRCKRHASREEAELVQQMAANIKERQDVFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEKFKLYLTIILLLGAVACRFVLHYRVTDEVFNFLLVWYYCTLTIRESILISNGSRIKGWWVSHHYVSTFLSGVMLTWPNGPIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALGERNHLDLTVEGFQSWMWRGLTFLLPFLFCGHFWQLYNAVTLFELSSHEECREWQVFVLAFTFLILFLGNFLTTLKVVHAKLQKNRGKTKQP", "length": 339 }, "evidence": [ { "id": "A6QPF8", "url": "https://omabrowser.org/oma/group/A6QPF8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q1LY80-1", "protein_name": "Transmembrane protein 120B", "gene_name": "tmem120b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSLERCQSEWTEIEQEYQQLQETHKVYRQKLEELTNLQAICSSAISKQRKGLKDLKQSLYKCKKSCNGKDSEVINDLQVQIKERQNVFFDMEAYLPKRNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEKFKLYMTIILMFGAVTCLFLLNYRVTDEIFNFLLVWYYCTLTIRESILRSNGSRIKGWWVSHHYVSTFLSGVMLTWPEGPMYQMFRSQFLAFSIYQSCVQFLQYYYQSGCLYRLRALGERNQLDLTVEGFQSWMWRGLTFLLPFLFFGHFWQLYNAVTLFRLSALDDCKEWQVFMLALTFLVLFLGNFLTTLKVVHQKLLKNKDKVKNN", "length": 337 }, "evidence": [ { "id": "A6QPF8", "url": "https://omabrowser.org/oma/group/A6QPF8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q3TA38-1", "protein_name": "Transmembrane protein 120B", "gene_name": "Tmem120b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGQLERCEREWHELEGEFQELQETHRIYKQKLEELTSLQTLCSTSISKQKRHLKDLKHTLQRYKRHSSHEEAALIQQMTANIKERQNVFFDMEAYLPKKNGLYLNLVLGNVSVTLLSNQAKFAYKDEYEKFKLYLTIILLLGAVACRFVLHYRVTDEVFNFLLVWYYCTLTIRESILISNGSRIKGWWVSHHYVSTFLSGVMLTWPNGLIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALGERNHLDLTVEGFQSWMWRGLTFLLPFLFCGHFWQLYNAVTLFELSTHEECKEWQVFVLALTFLILFLGNFLTTLKVVHAKLHKNRNKTKQP", "length": 339 }, "evidence": [ { "id": "A6QPF8", "url": "https://omabrowser.org/oma/group/A6QPF8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54IK2-1", "protein_name": "Transmembrane protein 120 homolog", "gene_name": "tmem120", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MMESFSETKSSIATNKSTTPTHEVQISKELQDIKNEVFELKKSHEQCKEKGIKVKKDINDVFKHADDITNTLAKHEKESSQLISRIKHLNAKEKQLDITKELSAHLDQIKVNVKRAKVSFTPETGSIFVRLFLGQVNVKHMRENEKFRLKQEYEKFKKKTNPQFILFVVLLLLYPQSSFVTTSWQIWLLYYYITLALRENILLVNGSSIKPWWIMHHYLSIAGSLTNLLFPLSESFSYFLPQVTYFSGCQGLVQILTNRYQQGRLYKLVAMGKANIIDVTGESEGWGNDPGWTPSALFLFPFLLFVQFFQLYNSFSFFAFAYQRSGYVEWQVFSCGFIFLCLGLGNLLTTLSVYYQKWKNFSKYNKEN", "length": 368 }, "evidence": [ { "id": "A6QPF8", "url": "https://omabrowser.org/oma/group/A6QPF8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9U1M2-1", "protein_name": "Transmembrane protein 120 homolog", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNIDSLKNEWEELNKEFAELESCNRRYIELLEQLHSHQQICFNEIKHQRYRMNQITTSLRQFKGPVPAEDKEKVDDLHKMTLKRKAQLHEIEQSLPAKSGRYLQIILGDVNVSILNRNDKVRYKDDYEKFKLILNVIGLIMAFFNLIFNYRALELAFIFLLVWYYCTLTIRESILKVNGSRIKGWWRAHHFISTVAAGVLLVWPQGEHWQIFRMQFMYFNVYISIVQYLQFGYQKGLLYRLKALGERHNMDITIEGFHSWMWRGLSFLLPFLFIGYGYQAYNAWTLYKLAYSPPDAPWHVSVMSGLFLLLFVGNMATTLWVVPEKIRERAKERYRLQSMGKSMKLRKEMKNSASDLDLSSGSKLSPTATTTTSIATATQTPAEKKET", "length": 387 }, "evidence": [ { "id": "A6QPF8", "url": "https://omabrowser.org/oma/group/A6QPF8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein heterooligomerization", "id": "GO:0051291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051291", "evidence": [ { "database": "UniProtKB", "id": "A6QPF8", "url": "https://www.uniprot.org/uniprotkb/A6QPF8" } ], "pmid": "" }, { "name": "fat cell differentiation", "id": "GO:0045444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045444", "evidence": [ { "database": "UniProtKB", "id": "A6QPF8", "url": "https://www.uniprot.org/uniprotkb/A6QPF8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear inner membrane", "id": "GO:0005637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005637", "evidence": [ { "database": "UniProtKB", "id": "A6QPF8", "url": "https://www.uniprot.org/uniprotkb/A6QPF8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 181, "end_pos": 183, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QPF8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 339, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QPF8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QPF8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 181, "end_pos": 183 }, { "start_pos": 332, "end_pos": 334 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q58DN3-1", "uniprot_ac": "Q58DN3", "uniprot_id": "TSN17_BOVIN", "mass": { "chemical_mass": 30262.0, "monoisotopic_mass": 30262.0 }, "refseq": { "ac": "NP_001014880", "name": "tetraspanin-17", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014880" }, "gene_names": [ { "name": "TSPAN17", "type": "recommended", "evidence": [ { "id": "Q58DN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN3" } ] }, { "name": "TM4SF17", "type": "synonym", "evidence": [ { "id": "NP_001014880", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014880" } ] }, { "name": "TSPAN17", "type": "synonym", "evidence": [ { "id": "NP_001014880", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014880" } ] } ], "protein_names": [ { "name": "Tetraspanin-17", "type": "recommended", "evidence": [ { "id": "Q58DN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN3/entry#names_and_taxonomy" } ] }, { "name": "Tspan-17", "type": "synonym", "evidence": [ { "id": "Q58DN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN3/entry#names_and_taxonomy" } ] }, { "name": "tetraspanin-17", "type": "synonym", "evidence": [ { "id": "NP_001014880", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014880" } ] }, { "name": "transmembrane 4 superfamily member 17", "type": "synonym", "evidence": [ { "id": "NP_001014880", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014880" } ] }, { "name": "tspan-17", "type": "synonym", "evidence": [ { "id": "NP_001014880", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014880" } ] } ], "function": [ { "annotation": "Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (By similarity). Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q58DN3", "url": "https://www.uniprot.org/uniprotkb/Q58DN3#function" }, { "database": "UniProtKB", "id": "Q96FV3", "url": "https://www.uniprot.org/uniprotkb/Q96FV3#function" }, { "database": "UniProtKB", "id": "Q9D7W4", "url": "https://www.uniprot.org/uniprotkb/Q9D7W4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DN3", "url": "https://www.uniprot.org/uniprotkb/Q58DN3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSPAN17", "url": "https://www.uniprot.org/uniprotkb/Q58DN3", "locus": { "chromosome": "7", "start_pos": 38126221, "end_pos": 38116164, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017451", "url": "https://www.ensembl.org/id/ENSBTAG00000017451" } ] } } ], "crossref": [ { "id": "Q58DN3", "url": "https://alphafold.ebi.ac.uk/entry/Q58DN3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017451", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017451", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03159", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03159", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509386", "url": "https://www.ncbi.nlm.nih.gov/gene/509386", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018503", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018503", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509386", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509386", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DWNPSRE", "url": "https://omabrowser.org/oma/group/DWNPSRE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LPJ5", "url": "https://www.orthodb.org/?gene=A0A3Q1LPJ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIV0", "url": "https://www.orthodb.org/?gene=A0A452DIV0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q58DN3", "url": "https://www.orthodb.org/?gene=Q58DN3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282:SF470", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282:SF470", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00335", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00335", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014880", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPJ5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIV0", "url": "https://www.uniprot.org/uniprotkb/A0A452DIV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIV0-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIV0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S519", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S519", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S519-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S519-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P433", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P433", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P433-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P433-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DN3", "url": "https://www.uniprot.org/uniprotkb/Q58DN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DN3-1", "url": "https://www.uniprot.org/uniprotkb/Q58DN3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGKHQHFQEPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWSEKGVLSNISALTDLGGLDPVWLFVVVGGVMSVLGFAGCIGALRENTFLLKFFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFVGIALLQIFGICLAQNLVSDIKAVKANW", "length": 270, "header": "sp|Q58DN3-1|TSN17_BOVIN Isoform 1 of Tetraspanin-17 OS=Bos taurus OX=9913 GN=TSPAN17 PE=1 SV=1 CANONICAL=Q58DN3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPJ5-1", "url": "https://www.uniprot.org/uniprotkb/Q58DN3/entry#A0A3Q1LPJ5-1", "sequence": { "sequence": "MPGKHQHFQEPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWSEKGVLSNISALTDLGGLDPVWLFVVVGGVMSVLGFAGCIGALRENTFLLKFFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLVREELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFVGIALLQIFGICLAQNLVSDIKAVKANW", "length": 273, "header": "tr|A0A3Q1LPJ5-1|TSN17_BOVIN Computationally mapped isoform of Tetraspanin-17 OS=Bos taurus OX=9913 GN=TSPAN17 PE=1 SV=2 CANONICAL=Q58DN3-1" }, "locus": { "chromosome": "7", "start_pos": 38124442, "end_pos": 38116275, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071126.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071126.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056851.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056851.2" } ] } }, { "isoform_ac": "A0A452DIV0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DN3/entry#A0A452DIV0-1", "sequence": { "sequence": "MPGKHQHFQEPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWSEKGVLSNISALTDLGGLDPVWLFVVVGGVMSVLGFAGCIGALRENTFLLKFFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFVGIALLQIFGICLAQNLVSDIKAVKANW", "length": 254, "header": "tr|A0A452DIV0-1|TSN17_BOVIN Computationally mapped isoform of Tetraspanin-17 OS=Bos taurus OX=9913 GN=TSPAN17 PE=1 SV=2 CANONICAL=Q58DN3-1" }, "locus": { "chromosome": "7", "start_pos": 38124442, "end_pos": 38116275, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023198.6", "url": "https://www.ensembl.org/id/ENSBTAT00000023198.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023198.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023198.5" } ] } }, { "isoform_ac": "A0AAA9S519-1", "url": "https://www.uniprot.org/uniprotkb/Q58DN3/entry#A0AAA9S519-1", "sequence": { "sequence": "MPGKHQHFQEPEVGCCGKYFLFGFNIVFWFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFVGIALLQVPLWPCTASLCPGQSALPPHLPSVFQIFGICLAQNLVSDIKAVKANW", "length": 188, "header": "tr|A0AAA9S519-1|TSN17_BOVIN Computationally mapped isoform of Tetraspanin-17 OS=Bos taurus OX=9913 GN=TSPAN17 PE=1 SV=1 CANONICAL=Q58DN3-1" }, "locus": { "chromosome": "7", "start_pos": 38124442, "end_pos": 38116275, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133085.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133085.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078945.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078945.1" } ] } }, { "isoform_ac": "A0ABI0P433-1", "url": "https://www.uniprot.org/uniprotkb/Q58DN3/entry#A0ABI0P433-1", "sequence": { "sequence": "MYFQCMRWSLELGGFCSRQVLGALFLAIGLWAWSEKGVLSNISALTDLGGLDPVWLFVVVGGVMSVLGFAGCIGALRENTFLLKFFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFVGIALLQIFGICLAQNLVSDIKAVKANWIKYDDGYKLLK", "length": 271, "header": "tr|A0ABI0P433-1|A0ABI0P433_BOVIN Computationally mapped isoform of Tetraspanin OS=Bos taurus OX=9913 GN=TSPAN17 PE=3 SV=1 CANONICAL=Q58DN3-1" }, "locus": { "chromosome": "7", "start_pos": 38124923, "end_pos": 38118400, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000140340.1", "url": "https://www.ensembl.org/id/ENSBTAT00000140340.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105568.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105568.1" } ] } }, { "isoform_ac": "Q58DN3-1", "url": "https://www.uniprot.org/uniprotkb/Q58DN3/entry#Q58DN3-1", "sequence": { "sequence": "MPGKHQHFQEPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWSEKGVLSNISALTDLGGLDPVWLFVVVGGVMSVLGFAGCIGALRENTFLLKFFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFVGIALLQIFGICLAQNLVSDIKAVKANW", "length": 270, "header": "sp|Q58DN3-1|TSN17_BOVIN Isoform 1 of Tetraspanin-17 OS=Bos taurus OX=9913 GN=TSPAN17 PE=1 SV=1 CANONICAL=Q58DN3-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 171, "start_aa": "Asn", "end_pos": 171, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn171", "evidence": [ { "id": "Q58DN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 51, "start_aa": "Asn", "end_pos": 51, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn51", "evidence": [ { "id": "Q58DN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN3#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DN3", "url": "https://www.uniprot.org/uniprotkb/Q58DN3" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression.", "journal": "J. Biol. Chem.", "date": "2012", "authors": "Haining Elizabeth J, Yang Jing, Bailey Rebecca L, Khan Kabir, Collier Richard, Tsai Schickwann, Watson Steve P, Frampton Jon, Garcia Paloma, Tomlinson Michael G", "evidence": [ { "database": "UniProtKB", "id": "Q58DN3", "url": "https://www.uniprot.org/uniprotkb/Q58DN3" } ], "reference": [ { "type": "PubMed", "id": "23035126", "url": "https://glygen.org/publication/PubMed/23035126" } ] } ], "pathway": [ { "id": "bta:509386", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509386", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q4V8E0-1", "protein_name": "Tetraspanin-17", "gene_name": "Tspan17", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPGKHQQFQDPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWGEKGVLSNISGLTDLGGLDPVWLFVVIGGIMSVLGFAGCIGALRENTFLLKFFSVFLGLIFFLELAAGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDIRLKLELEQQGSIYTKGCVGQFEKWLQDNLIVVAGVLVAIALLQICGICLAQNLVSDIEAVKANW", "length": 270 }, "evidence": [ { "id": "Q58DN3", "url": "https://omabrowser.org/oma/group/Q58DN3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96FV3-1", "protein_name": "Tetraspanin-17", "gene_name": "TSPAN17", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPGKHQHFQEPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWGEKGVLSNISALTDLGGLDPVWLFVVVGGVMSVLGFAGCIGALRENTFLLKFFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFMGIALLQIFGICLAQNLVSDIKAVKANW", "length": 270 }, "evidence": [ { "id": "Q58DN3", "url": "https://omabrowser.org/oma/group/Q58DN3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q58DN3", "url": "https://www.uniprot.org/uniprotkb/Q58DN3" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q58DN3", "url": "https://www.uniprot.org/uniprotkb/Q58DN3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of membrane protein ectodomain proteolysis", "id": "GO:0051043", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051043", "evidence": [ { "database": "UniProtKB", "id": "Q58DN3", "url": "https://www.uniprot.org/uniprotkb/Q58DN3" } ], "pmid": "" }, { "name": "establishment of protein localization to organelle", 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phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8#function" }, { "database": "UniProtKB", "id": "Q03426", "url": "https://www.uniprot.org/uniprotkb/Q03426#function" }, { "database": "UniProtKB", "id": "A0A3Q1LJQ9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJQ9#function" }, { "database": "UniProtKB", "id": "RU363087", "url": "https://www.uniprot.org/uniprotkb/RU363087#function" }, { "database": "UniProtKB", "id": "ARBA00053839", "url": "https://www.uniprot.org/uniprotkb/ARBA00053839#function" }, { "database": "UniProtKB", "id": "A0A3Q1LS18", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS18#function" } ] }, { "annotation": "Expression of LHR mRNA in bovine granulosa cells is established after follicle deviation, and the lower abundance of LRBP mRNA after the expected time of deviation may contribute to greater 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"https://www.ebi.ac.uk/interpro/entry/IPR014721", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020568", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020568", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036554", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036554", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505792", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505792", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LMDFNHG", "url": "https://omabrowser.org/oma/group/LMDFNHG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LJQ9", "url": "https://www.orthodb.org/?gene=A0A3Q1LJQ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LS18", "url": "https://www.orthodb.org/?gene=A0A3Q1LS18", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5E9T8", "url": "https://www.orthodb.org/?gene=Q5E9T8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43290", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43290", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43290:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43290:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00288", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00288", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08544", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08544", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9969896", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9969896", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015528", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17065", "url": "https://www.rhea-db.org/rhea/17065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LJQ9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LS18", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LS18-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS18-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TN18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TN18-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN18-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YN97", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YN97-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YN97-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9T8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRRAWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSICQSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEENLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVPRSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDMNQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDVERPAVEATKRALSGCGFDCWETSVGAPGVSVHTAASLDASVQQGLDSL", "length": 396, "header": "sp|Q5E9T8-1|KIME_BOVIN Isoform 1 of Mevalonate kinase OS=Bos taurus OX=9913 GN=MVK PE=2 SV=1 CANONICAL=Q5E9T8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJQ9-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8/entry#A0A3Q1LJQ9-1", "sequence": { "sequence": "MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRRAWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSICQSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEENLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVPRSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDMNQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDSRRRNVCREPGTGLVPPISLPAKLSTSLRNNQGIVTIYHHRHHYQPCIPAVTS", "length": 400, "header": "tr|A0A3Q1LJQ9-1|KIME_BOVIN Computationally mapped isoform of Mevalonate kinase OS=Bos taurus OX=9913 GN=MVK PE=2 SV=2 CANONICAL=Q5E9T8-1" }, "locus": { "chromosome": "17", "start_pos": 63627305, "end_pos": 63610995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077288.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077288.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059705.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059705.2" } ] } }, { "isoform_ac": "A0A3Q1LS18-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8/entry#A0A3Q1LS18-1", "sequence": { "sequence": "MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRRAWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSICQSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEENLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVPRSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDMNQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDRETEAQRGRETRPRPHS", "length": 364, "header": "tr|A0A3Q1LS18-1|KIME_BOVIN Computationally mapped isoform of Mevalonate kinase OS=Bos taurus OX=9913 GN=MVK PE=2 SV=2 CANONICAL=Q5E9T8-1" }, "locus": { "chromosome": "17", "start_pos": 63627305, "end_pos": 63607635, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070586.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070586.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057879.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057879.2" } ] } }, { "isoform_ac": "A0AAA9TN18-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8/entry#A0AAA9TN18-1", "sequence": { "sequence": "MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRRAWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSICQSQRWTEENLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVPRSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDMNQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDVERPAVEATKRALSGCGFDCWETSVGAPGVSVHTAASLDASVQQGLDSL", "length": 344, "header": "tr|A0AAA9TN18-1|KIME_BOVIN Computationally mapped isoform of Mevalonate kinase OS=Bos taurus OX=9913 GN=MVK PE=2 SV=1 CANONICAL=Q5E9T8-1" }, "locus": { "chromosome": "17", "start_pos": 63627305, "end_pos": 63610184, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131926.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131926.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098386.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098386.1" } ] } }, { "isoform_ac": "A0AAF6YN97-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8/entry#A0AAF6YN97-1", "sequence": { "sequence": "MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRRAWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSICQSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEENLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVPRSTKVLVANVRSRLLKELIDMNQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDVERPAVEATKRALSGCGFDCWETSVGAPGVSVHTAASLDASVQQGLDSL", "length": 357, "header": "tr|A0AAF6YN97-1|KIME_BOVIN Computationally mapped isoform of Mevalonate kinase OS=Bos taurus OX=9913 GN=MVK PE=2 SV=1 CANONICAL=Q5E9T8-1" }, "locus": { "chromosome": "17", "start_pos": 63627305, "end_pos": 63610184, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006828.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006828.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006828.7", "url": "https://www.ensembl.org/id/ENSBTAP00000006828.7" } ] } }, { "isoform_ac": "Q5E9T8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8/entry#Q5E9T8-1", "sequence": { "sequence": "MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRRAWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSICQSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEENLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVPRSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDMNQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDVERPAVEATKRALSGCGFDCWETSVGAPGVSVHTAASLDASVQQGLDSL", "length": 396, "header": "sp|Q5E9T8-1|KIME_BOVIN Isoform 1 of Mevalonate kinase OS=Bos taurus OX=9913 GN=MVK PE=2 SV=1 CANONICAL=Q5E9T8-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 287, "start_aa": "Thr", "end_pos": 287, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr287", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "Expression of mRNA Encoding the LH Receptor (LHR) and LHR Binding Protein in Granulosa Cells from Nelore (Bos indicus) Heifers Around Follicle Deviation.", "journal": "Reproduction in domestic animals = Zuchthygiene", "date": "2015-12", "authors": "Ereno R L, Loureiro B, Castilho A C S, Machado M F, Pegorer M F, Satrapa R A, Nogueira M F G, Buratini J, Barros C M", "evidence": [ { "database": "RefSeq", "id": "NP_001015528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015528" } ], "reference": [ { "type": "PubMed", "id": "26446749", "url": "https://glygen.org/publication/PubMed/26446749" } ] } ], "pathway": [ { "id": "bta:505792", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505792", "resource": "KEGG Pathway" }, { "id": "R-BTA-9969896", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9969896", "resource": "Reactome", "description": "Lanosterol biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7GV86-1", "protein_name": "Mevalonate kinase", "gene_name": "Mvk", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLSEALLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLLLRPQSNGKVSLNLPNIGIKQVWDVAGLQLLDTNFLEQGDGPAPTPEQLEKLKKVAGLPEDGVGTEGLAVLAFLYLYLAICRKQRVLPSLDIVVWSELPPGAGLGSSAAYSVCLVAALLTACENITNPLKDRDAISRWSEEDLESINKWAYEGERVIHGNPSGVDNAVSTWGGALRYQQGKMSSLKRLPALQILLTNTKVPRSTKALVAGVRSRLLKFPEIVTPLLTSIDAISLECERVLGEMVAAPAPEQYLVLEELIDMNQHHLNALGVGHTSLDQLCRITAAHGLHSKLTGAGGGGCGITLLKPGETEAQRGYLCPEQQTQASNLVTAAAEAGVPRSLSNRLSPAICLKEQSLSRPSPNTATKMHAVDRDIEADTELGNDPFLDTVCLQ", "length": 431 }, "evidence": [ { "id": "Q5E9T8", "url": "https://omabrowser.org/oma/group/Q5E9T8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P07277-1", "protein_name": "Mevalonate kinase", "gene_name": "ERG12", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFENKTTTKQQIDDLLLPGNTNLPWTS", "length": 443 }, "evidence": [ { "id": "Q5E9T8", "url": "https://omabrowser.org/oma/group/Q5E9T8/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P17256-1", "protein_name": "Mevalonate kinase", "gene_name": "Mvk", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLVLRPQSNGKVSLNLPNVGIKQVWDVATLQLLDTGFLEQGDVPAPTLEQLEKLKKVAGLPRDCVGNEGLSLLAFLYLYLAICRKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCVAAALLTACEEVTNPLKDRGSIGSWPEEDLKSINKWAYEGERVIHGNPSGVDNSVSTWGGALRYQQGKMSSLKRLPALQILLTNTKVPRSTKALVAGVRSRLIKFPEIMAPLLTSIDAISLECERVLGEMAAAPVPEQYLVLEELMDMNQHHLNALGVGHASLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLERAKVEAAKQALTGCGFDCWETSIGAPGVSMHSATSIEDPVRQALGL", "length": 395 }, "evidence": [ { "id": "Q5E9T8", "url": "https://omabrowser.org/oma/group/Q5E9T8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P46086-1", "protein_name": "Mevalonate kinase", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEVKARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFPLPSAENNDRLTLQLKDISLEFSWSLARIKEAIPYDSSTLCRSTPASCSEETLKSIAVLVEEQNLPKEKMWLSSGISTFLWLYTRIIGFNPATVVINSELPYGSGLGSSAALCVALTAALLASSISEKTRGNGWSSLDETNLELLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGEITRLQSNMPLRMLITNTRVGRNTKALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDETSVTEKEERIKELMEMNQGLLLSMGVSHSSIEAVILTTVKHKLVSKLTGAGGGGCVLTLLPTGTVVDKVVEELESSGFQCFTALIGGNGAQICY", "length": 378 }, "evidence": [ { "id": "Q5E9T8", "url": "https://omabrowser.org/oma/group/Q5E9T8/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q03426-1", "protein_name": "Mevalonate kinase", "gene_name": "MVK", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL", "length": 396 }, "evidence": [ { "id": "Q5E9T8", "url": "https://omabrowser.org/oma/group/Q5E9T8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q86AG7-1", "protein_name": "Mevalonate kinase", "gene_name": "mvk", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MISNQDNIIQVSAPGKIILFGEHAVVLEKTAIASALSLRTTVTFTPNTNNTLLLDFPDLAGFGVREWSLDEFKKLDHFPNDIDILKPIECSELFQQELNKIIDIKGIHTFLFLFCALTKCTKAYNIKITSDLPIGAGLGSSASFCVSICAGLLKAFDTYICGGCKQCIGGQGQQQQICNEQLNLINLWSLQGEKIMHGTPSGIDNAVATFGKALTFTRKNGYKILENGIPPLRILITNTRVSRSTKTLVEGVIQRSKLYPTLIDPVSNLIDTISSQCIESFNQYHTDKDYEKLQQTMDLMFDMNQHLLSGCYGVGHSSIDTIVSITKSLGFHTKLTGAGGGGCVITLLKQDTTIDQLSNLKLTLSSNGFESWEATIGDPGVSINILPIQK", "length": 390 }, "evidence": [ { "id": "Q5E9T8", "url": "https://omabrowser.org/oma/group/Q5E9T8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9R008-1", "protein_name": "Mevalonate kinase", "gene_name": "Mvk", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSEALLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQVWDVGMLQRLDTSFLEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLPSLQILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVPEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLEQATVEAAKQALTSCGFDCWETSIGAPGVSTHSAAAVGDPVRQALGL", "length": 395 }, "evidence": [ { "id": "Q5E9T8", "url": "https://omabrowser.org/oma/group/Q5E9T8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "pmid": "" }, { "name": "mevalonate kinase activity", "id": "GO:0004496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004496", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "cholesterol biosynthetic process", "id": "GO:0006695", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006695", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "pmid": "" }, { "name": "isopentenyl diphosphate biosynthetic process, mevalonate pathway", "id": "GO:0019287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019287", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "pmid": "" }, { "name": "negative regulation of inflammatory response", "id": "GO:0050728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050728", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "pmid": "" }, { "name": "geranylgeranyl diphosphate biosynthetic process", "id": "GO:0033386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033386", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "pmid": "" }, { "name": "cholesterol biosynthetic process via desmosterol", "id": "GO:0033489", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033489", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "pmid": "" }, { "name": "cholesterol biosynthetic process via lathosterol", "id": "GO:0033490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033490", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "pmid": "" }, { "name": "farnesyl diphosphate biosynthetic process, mevalonate pathway", "id": "GO:0010142", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010142", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "pmid": "" }, { "name": "zymosterol biosynthetic process", "id": "GO:0036197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036197", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "pmid": "" }, { "name": "sterol biosynthetic process", "id": "GO:0016126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016126", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "pmid": "" }, { "name": "isoprenoid biosynthetic process", "id": "GO:0008299", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008299", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T8", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17065", "name": "", "equation": "(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9T8-1" ], "evidence": [ { "id": "17065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17065" } ] }, { "id": "R-BTA-191380", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-191424" ], "output_participant_list": [ "R-ALL-191296" ], "enzyme_list": [ "Q5E9T8-1" ], "evidence": [ { "id": "R-BTA-191380", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-191380" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-191296", "participant_name": "MVA5P [cytosol]", "crossref": [ { "id": "ZINC000001532853", "database": "ZINC", "url": "" }, { "id": "58146", "database": "ChEBI", "url": "" }, { "id": "C01107", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-191424", "participant_name": "MVA [cytosol]", "crossref": [ { "id": "36464", "database": "ChEBI", "url": "" }, { "id": "MEVALONATE", "database": "AraCyc", "url": "" }, { "id": "C00418", "database": "KEGG Gene", "url": "" }, { "id": "5288798", "database": "PubChem Compound", "url": "" }, { "id": "C00418", "database": "COMPOUND", "url": "" }, { "id": "3042", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "ZINC000000895221", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q5E9T8", "gene_name": "MVK", "activity": [ { "ec_number": "2.7.1.36", "activity": "(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+).", "evidence": [ { "id": "Q5E9T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ] }, { "ec_number": "2.7.1.36", "activity": "", "evidence": [ { "id": "Q5E9T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9T8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 396, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9T8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9T8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q5E9T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8#function" }, { "id": "Q5E9T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "binding_site_uniprot": 146, "amino_acid": "Ser", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 146, "end_pos": 146, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5E9T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8#function" }, { "id": "Q5E9T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9T8" } ], "binding_site_uniprot": 193, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 193, "end_pos": 193, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.1.36", "ec_name": "(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+).", "evidence": [ { "id": "2.7.1.36", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.36" }, { "id": "2.7.1.36", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.36" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 287 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": 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[ { "id": "Q5E9J9", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9J9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000056", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000056", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08227", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08227", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515024", "url": "https://www.ncbi.nlm.nih.gov/gene/515024", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047173", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047173", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515024", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515024", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "INGVMPF", "url": "https://omabrowser.org/oma/group/INGVMPF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LPE0", "url": "https://www.orthodb.org/?gene=A0A3Q1LPE0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MX20", "url": "https://www.orthodb.org/?gene=A0A3Q1MX20", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6QWI1", "url": "https://www.orthodb.org/?gene=F6QWI1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5E9J9", "url": "https://www.orthodb.org/?gene=Q5E9J9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48014", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48014", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48014:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48014:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-380972", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380972", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015603", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPE0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPE0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MN91", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MN91-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MX20", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MX20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MX20-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MX20-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZX2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8Y1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8Y1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Y1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWM7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A9L2", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9L2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A9L2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9L2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QWI1", "url": "https://www.uniprot.org/uniprotkb/F6QWI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QWI1-1", "url": "https://www.uniprot.org/uniprotkb/F6QWI1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9J9", "url": "https://www.uniprot.org/uniprotkb/Q5E9J9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9J9-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFSHPNILPYGATFIADNELWVVTSFMAYGSAKDLICTHFMDGMSELAIAYILQGALKALDYIHHMGYVHRSVKASHVLISADGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSIKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSTSRSAANSGLSESLAPSTPRTSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDMRPSASTLLNHSFFKQIKRRASEALPELLRPVTPITTFEGRQSQDHSGIFGLVTNLEELEVDDWEF", "length": 373, "header": "sp|Q5E9J9-1|STRAA_BOVIN Isoform 1 of STE20-related kinase adapter protein alpha OS=Bos taurus OX=9913 GN=STRADA PE=2 SV=1 CANONICAL=Q5E9J9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPE0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J9/entry#A0A3Q1LPE0-1", "sequence": { "sequence": "MSFLVSKPERIRRWVSEKFIVEGLRDLELFGGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFSHPNILPYGATFIADNELWVVTSFMAYGSAKDLICTHFMDGMSELAIAYILQGALKALDYIHHMGYVHRSVKASHVLISADGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSIKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSTSRSAANSGLSESLAPSTPRTSNDQAPAPS", "length": 299, "header": "tr|A0A3Q1LPE0-1|STRAA_BOVIN Computationally mapped isoform of STE20-related kinase adapter protein alpha OS=Bos taurus OX=9913 GN=STRADA PE=2 SV=2 CANONICAL=Q5E9J9-1" }, "locus": { "chromosome": "19", "start_pos": 47999287, "end_pos": 47981379, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081130.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081130.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058786.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058786.2" } ] } }, { "isoform_ac": "A0A3Q1MN91-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J9/entry#A0A3Q1MN91-1", "sequence": { "sequence": "MSFLVSKPERIRRWVSEKFIVEGLRDLELFGEQPPGDARRKTNEASSESIASFSKPEIMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFSHPNILPYGATFIADNELWVVTSFMAYGSAKDLICTHFMDGMSELAIAYILQGALKALDYIHHMGYVHRSVKASHVLISADGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSIKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSTSRSAANSGLSESLAPSTPRTSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDMRSSDVPQKLCPSYSDLSPPSPLLKADSLRITVGSLAW", "length": 403, "header": "tr|A0A3Q1MN91-1|STRAA_BOVIN Computationally mapped isoform of STE20-related kinase adapter protein alpha OS=Bos taurus OX=9913 GN=STRADA PE=2 SV=1 CANONICAL=Q5E9J9-1" }, "locus": { "chromosome": "19", "start_pos": 47999287, "end_pos": 47980777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069237.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069237.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073373.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073373.2" } ] } }, { "isoform_ac": "A0A3Q1MX20-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J9/entry#A0A3Q1MX20-1", "sequence": { "sequence": "MSFLVSKPERIRRWVSEKFIVEGLRDLELFGEQPPGDARRKTNEASSESIASFSKPEIMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFSHPNILPYGATFIADNELWVVTSFMAYGSAKDLICTHFMDGMSELAIAYILQGALKALDYIHHMGYVHRSVKASHVLISADGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSIKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSTSRSAANSGLSESLAPSTPRTSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDMRPSASTLLNHSFFKQIKRRASEALPELLRPVTPITTFEGRQSQDHSGIFGLVTNLEELEVDDWEF", "length": 431, "header": "tr|A0A3Q1MX20-1|STRAA_BOVIN Computationally mapped isoform of STE20-related kinase adapter protein alpha OS=Bos taurus OX=9913 GN=STRADA PE=2 SV=1 CANONICAL=Q5E9J9-1" }, "locus": { "chromosome": "19", "start_pos": 47999287, "end_pos": 47980736, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080981.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080981.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060197.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060197.1" } ] } }, { "isoform_ac": "A0AAA9RZX2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J9/entry#A0AAA9RZX2-1", "sequence": { "sequence": "MTTFVPFAGSSKTNEASSESIASFSKPEIMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFSHPNILPYGATFIADNELWVVTSFMAYGSAKDLICTHFMDGMSELAIAYILQGALKALDYIHHMGYVHRSVKASHVLISADGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSIKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSTSRSAANSGLSESLAPSTPRTSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDMRPSASTLLNHSFFKQIKRRASEALPELLRPVTPITTFEGRQSQDHSGIFGLVTNLEELEVDDWEF", "length": 402, "header": "tr|A0AAA9RZX2-1|STRAA_BOVIN Computationally mapped isoform of STE20-related kinase adapter protein alpha OS=Bos taurus OX=9913 GN=STRADA PE=2 SV=1 CANONICAL=Q5E9J9-1" }, "locus": { "chromosome": "19", "start_pos": 47993976, "end_pos": 47980736, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123828.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123828.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076628.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076628.1" } ] } }, { "isoform_ac": "A0AAA9S8Y1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J9/entry#A0AAA9S8Y1-1", "sequence": { "sequence": "MSFLVSKPERIRRWVSEKFIVEGLRDLELFGEQPPGDARRKTNEASSESIASFSKPEIMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFSHPNILPYGATFIADNELWVVTSFMAYGSAKDLICTHFMDGMSELAIAYILQGALKALDYIHHMGYVHRISRVTMPSLTSTVWESRPVSWPMATSPLKTCLPPRSSDVPQKLCPSYSDLSPPSPLLKADSLRITVGSLAW", "length": 265, "header": "tr|A0AAA9S8Y1-1|STRAA_BOVIN Computationally mapped isoform of STE20-related kinase adapter protein alpha OS=Bos taurus OX=9913 GN=STRADA PE=2 SV=2 CANONICAL=Q5E9J9-1" }, "locus": { "chromosome": "19", "start_pos": 47999287, "end_pos": 47980777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122310.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122310.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080378.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080378.2" } ] } }, { "isoform_ac": "A0AAA9SWM7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J9/entry#A0AAA9SWM7-1", "sequence": { "sequence": "MSFLVSKPERIRTNEASSESIASFSKPEIMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFSHPNILPYGATFIADNELWVVTSFMAYGSAKDLICTHFMDGMSELAIAYILQGALKALDYIHHMGYVHRSVKASHVLISADGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSIKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSTSRSAANSGLSESLAPSTPRTSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDMRPSASTLLNHSFFKQIKRRASEALPELLRPVTPITTFEGRQSQDHSGIFGLVTNLEELEVDDWEF", "length": 402, "header": "tr|A0AAA9SWM7-1|STRAA_BOVIN Computationally mapped isoform of STE20-related kinase adapter protein alpha OS=Bos taurus OX=9913 GN=STRADA PE=2 SV=1 CANONICAL=Q5E9J9-1" }, "locus": { "chromosome": "19", "start_pos": 47999287, "end_pos": 47980736, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094974.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094974.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088634.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088634.1" } ] } }, { "isoform_ac": "A0AAF7A9L2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J9/entry#A0AAF7A9L2-1", "sequence": { "sequence": "MSFLVSKPERIRRWVSEKFIVEGLRDLELFGEQPPGDARRKTNEASSESIASFSKPEIMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFSHPNILPYGATFIADNELWVVTSFMAYGSAKDLICTHFMDGMSELAIAYILQGALKALDYIHHMGYVHRSVKASHVLISADGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSIKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQIKRRASEALPELLRPVTPITTFEGRQSQDHSGIFGLVTNLEELEVDDWEF", "length": 336, "header": "tr|A0AAF7A9L2-1|STRAA_BOVIN Computationally mapped isoform of STE20-related kinase adapter protein alpha OS=Bos taurus OX=9913 GN=STRADA PE=2 SV=1 CANONICAL=Q5E9J9-1" }, "locus": { "chromosome": "19", "start_pos": 47999287, "end_pos": 47980736, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079716.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079716.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065115.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065115.2" } ] } }, { "isoform_ac": "F6QWI1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J9/entry#F6QWI1-1", "sequence": { "sequence": "MPTTNFSTPEQPPGDARRKTNEASSESIASFSKPEIMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFSHPNILPYGATFIADNELWVVTSFMAYGSAKDLICTHFMDGMSELAIAYILQGALKALDYIHHMGYVHRSVKASHVLISADGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSIKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSTSRSAANSGLSESLAPSTPRTSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDMRPSASTLLNHSFFKQIKRRASEALPELLRPVTPITTFEGRQSQDHSGIFGLVTNLEELEVDDWEF", "length": 409, "header": "tr|F6QWI1-1|STRAA_BOVIN Computationally mapped isoform of STE20-related kinase adapter protein alpha OS=Bos taurus OX=9913 GN=STRADA PE=2 SV=2 CANONICAL=Q5E9J9-1" }, "locus": { "chromosome": "19", "start_pos": 47994669, "end_pos": 47980736, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053961.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053961.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051279.4", "url": "https://www.ensembl.org/id/ENSBTAP00000051279.4" } ] } }, { "isoform_ac": "Q5E9J9-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J9/entry#Q5E9J9-1", "sequence": { "sequence": "MSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFSHPNILPYGATFIADNELWVVTSFMAYGSAKDLICTHFMDGMSELAIAYILQGALKALDYIHHMGYVHRSVKASHVLISADGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSIKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSTSRSAANSGLSESLAPSTPRTSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDMRPSASTLLNHSFFKQIKRRASEALPELLRPVTPITTFEGRQSQDHSGIFGLVTNLEELEVDDWEF", "length": 373, "header": "sp|Q5E9J9-1|STRAA_BOVIN Isoform 1 of STE20-related kinase adapter protein alpha OS=Bos taurus OX=9913 GN=STRADA PE=2 SV=1 CANONICAL=Q5E9J9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 361, "end_pos": 361, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by LKB1", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J9", "url": "https://www.uniprot.org/uniprotkb/Q5E9J9" } ], "site_lbl": "Thr361" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J9", "url": "https://www.uniprot.org/uniprotkb/Q5E9J9" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:515024", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515024", "resource": "KEGG Pathway" }, { "id": "R-BTA-380972", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380972", "resource": "Reactome", "description": "Energy dependent regulation of mTOR by LKB1-AMPK" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LZ81-1", "protein_name": "STE20-related kinase adapter protein alpha", "gene_name": "Strada", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSFLVSKPERIRRWVSEKFIVEGLRDLELFGEQPPGDTRRKANEASSESIASFSKPEIMSSFLPEGGCYELLTVIGKGFEELMTVNLARYKPTGEYVTIRRINLEACSNEMVTFLQGELHVSKLFSHPNIVPYRATFISDNELWVVTSFMAYGSAKDLIGTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISMDGKVYLSGLRSNLSMISHGQRQRAVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSIANPSLNDSLATSNLRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPNASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQSQDPSGIFSLVTDLEGLEVDDWEF", "length": 431 }, "evidence": [ { "id": "Q5E9J9", "url": "https://omabrowser.org/oma/group/Q5E9J9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8M9P4U0-1", "protein_name": "STE20-related kinase adapter protein alpha", "gene_name": "strada", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKVLLPVIITISGSMSFLRWVSEKLSVESLRDLELFGEQTQASPLRKAHEDSRESLNPLPHRDTMGSFLPDSSAYELRNVIGRGLESLMTVNLAVYKPTGEYVAIRRIDLDSCANDMVSYLQGELRVSKLFHHPCILPYKSVFIAENELWVITPFMAYGSARDLIITHFTDGLNEQTIAYILLGVLRALEYIHQMGYVHRSVKASHILISADGQMFLSGLRSIFSLIRHGQRARVVHDFPQYSVKVLPWLSPEVLQQNLQGYDFRSDIYSLGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTTTIPPEELSMKPSRSGADSGICEGPGAGGARHTNGEPSSSSGGNPYSRTFSSHFHAFVELCLQRDPEKRPSASSLIGHSFFKQIKRRPSEALPELLRPVSPISSLDSMQHQDSPTGLASLESDLSQLDVDDWDF", "length": 442 }, "evidence": [ { "id": "Q5E9J9", "url": "https://omabrowser.org/oma/group/Q5E9J9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { 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}, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q861R0-1", "uniprot_ac": "Q861R0", "uniprot_id": "SOCS2_BOVIN", "mass": { "chemical_mass": 22214.0, "monoisotopic_mass": 22214.0 }, "refseq": { "ac": "NP_803489", "name": "suppressor of cytokine signaling 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803489" }, "gene_names": [ { "name": "SOCS2", "type": "recommended", "evidence": [ { "id": "Q861R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q861R0" } ] }, { "name": "SOCS2", "type": "synonym", "evidence": [ { "id": "NP_803489", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803489" } ] } ], "protein_names": [ { "name": "Suppressor of cytokine signaling 2", "type": "recommended", "evidence": [ { "id": "Q861R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q861R0/entry#names_and_taxonomy" } ] }, { "name": "SOCS-2", "type": "synonym", "evidence": [ { "id": "NP_803489", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803489" }, { "id": "Q861R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q861R0/entry#names_and_taxonomy" } ] }, { "name": "suppressor of cytokine signaling 2", "type": "synonym", "evidence": [ { "id": "NP_803489", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803489" } ] } ], "function": [ { "annotation": "Hepatic growth hormone receptor and suppressor of cytokine signaling (SOCS)2 messenger RNA expression appeared to be promptly and sensitively regulated by increased estradiol levels before ovulation of dairy heifers", "evidence": [ { "database": "RefSeq", "id": "NP_803489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803489" }, { "database": "PubMed", "id": "25704974", "url": "https://glygen.org/publication/PubMed/25704974" } ] }, { "annotation": "Relative amount of suppressors of cytokine signaling-2 (SOCS-2)messenger RNA increased after parturition", "evidence": [ { "database": "RefSeq", "id": "NP_803489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803489" }, { "database": "PubMed", "id": "18292263", "url": "https://glygen.org/publication/PubMed/18292263" } ] }, { "annotation": "Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2. 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"sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q56JW4-1", "uniprot_ac": "Q56JW4", "uniprot_id": "APT_BOVIN", "mass": { "chemical_mass": 19537.0, "monoisotopic_mass": 19537.0 }, "refseq": { "ac": "NP_001020505", "name": "adenine phosphoribosyltransferase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020505" }, "gene_names": [ { "name": "APRT", "type": "recommended", "evidence": [ { "id": "Q56JW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ] }, { "name": "APRT", "type": "synonym", "evidence": [ { "id": "NP_001020505", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020505" } ] } ], "protein_names": [ { "name": "Adenine phosphoribosyltransferase", "type": "recommended", "evidence": [ { "id": "Q56JW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JW4/entry#names_and_taxonomy" } ] }, { "name": "2.4.2.7", "type": "synonym", "evidence": [ { "id": "Q56JW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JW4/entry#names_and_taxonomy" } ] }, { "name": "APRT", "type": "synonym", "evidence": [ { "id": "Q56JW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JW4/entry#names_and_taxonomy" } ] }, { "name": "adenine phosphoribosyltransferase", "type": "synonym", "evidence": [ { "id": "NP_001020505", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020505" } ] } ], "function": [ { "annotation": "Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.", "evidence": [ { "database": "UniProtKB", "id": "A0A452DIE3", "url": "https://www.uniprot.org/uniprotkb/A0A452DIE3#function" }, { "database": "UniProtKB", "id": "ARBA00003968", "url": "https://www.uniprot.org/uniprotkb/ARBA00003968#function" }, { "database": "UniProtKB", "id": "Q56JW4", "url": "https://www.uniprot.org/uniprotkb/Q56JW4#function" }, { "database": "UniProtKB", "id": "P07741", "url": "https://www.uniprot.org/uniprotkb/P07741#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q56JW4", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "APRT", "url": "https://www.uniprot.org/uniprotkb/Q56JW4", "locus": { "chromosome": "18", "start_pos": 14012897, "end_pos": 14016023, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000639", "url": "https://www.ensembl.org/id/ENSBTAG00000000639" } ] } } ], "crossref": [ { "id": "Q56JW4", "url": "https://alphafold.ebi.ac.uk/entry/Q56JW4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000639", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000639", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06223", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06223", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "519017", "url": "https://www.ncbi.nlm.nih.gov/gene/519017", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000836", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000836", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005764", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005764", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519017", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519017", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QAYDLEY", "url": "https://omabrowser.org/oma/group/QAYDLEY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIE3", "url": "https://www.orthodb.org/?gene=A0A452DIE3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q56JW4", "url": "https://www.orthodb.org/?gene=Q56JW4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32315", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32315", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32315:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32315:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00156", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00156", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-74217", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-74217", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001020505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020505", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16609", "url": "https://www.rhea-db.org/rhea/16609", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DIE3", "url": "https://www.uniprot.org/uniprotkb/A0A452DIE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIE3-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIE3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JW4", "url": "https://www.uniprot.org/uniprotkb/Q56JW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JW4-1", "url": "https://www.uniprot.org/uniprotkb/Q56JW4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADPELQLVARRIRSFPNFPIPGVLFRDISPVLKDPTSFRASINLLANHLKKAHGGRIDYIAGLDSRGFLFGPSLAQELGLGCILIRKRGKLPGPTVCASYALEYGKGELEIQRDALEPGQKVVVVDDLLATGGTMCAACELLGQLRAEVLECVSLVELTSLKGREKLGAVPFFSLLQYE", "length": 180, "header": "sp|Q56JW4-1|APT_BOVIN Isoform 1 of Adenine phosphoribosyltransferase OS=Bos taurus OX=9913 GN=APRT PE=2 SV=1 CANONICAL=Q56JW4-1" }, "isoforms": [ { "isoform_ac": "A0A452DIE3-1", "url": "https://www.uniprot.org/uniprotkb/Q56JW4/entry#A0A452DIE3-1", "sequence": { "sequence": "MKYGTSCGRKWPRSLGSRPAPPHRAGAELLSLPLASGPTPWTPLPLRAGAEPPSRPVVPATRAEVAMADPELQLVARRIRSFPNFPIPGVLFRDISPVLKDPTSFRASINLLANHLKKAHGGRIDYIAGLDSRGFLFGPSLAQELGLGCILIRKRGKLPGPTVCASYALEYGKGELEIQRDALEPGQKVVVVDDLLATGGTMCAACELLGQLRAEVLECVSLVELTSLKGREKLGAVPFFSLLQYE", "length": 246, "header": "tr|A0A452DIE3-1|APT_BOVIN Computationally mapped isoform of Adenine phosphoribosyltransferase OS=Bos taurus OX=9913 GN=APRT PE=2 SV=1 CANONICAL=Q56JW4-1" }, "locus": { "chromosome": "18", "start_pos": 14015824, "end_pos": 14013289, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000841.5", "url": "https://www.ensembl.org/id/ENSBTAT00000000841.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000841.4", "url": "https://www.ensembl.org/id/ENSBTAP00000000841.4" } ] } }, { "isoform_ac": "Q56JW4-1", "url": "https://www.uniprot.org/uniprotkb/Q56JW4/entry#Q56JW4-1", "sequence": { "sequence": "MADPELQLVARRIRSFPNFPIPGVLFRDISPVLKDPTSFRASINLLANHLKKAHGGRIDYIAGLDSRGFLFGPSLAQELGLGCILIRKRGKLPGPTVCASYALEYGKGELEIQRDALEPGQKVVVVDDLLATGGTMCAACELLGQLRAEVLECVSLVELTSLKGREKLGAVPFFSLLQYE", "length": 180, "header": "sp|Q56JW4-1|APT_BOVIN Isoform 1 of Adenine phosphoribosyltransferase OS=Bos taurus OX=9913 GN=APRT PE=2 SV=1 CANONICAL=Q56JW4-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 96, "start_aa": "Thr", "end_pos": 96, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr96", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 135, "end_pos": 135, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q56JW4", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ], "site_lbl": "Thr135" }, { "start_pos": 15, "end_pos": 15, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q56JW4", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ], "site_lbl": "Ser15" }, { "start_pos": 30, "end_pos": 30, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q56JW4", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ], "site_lbl": "Ser30" }, { "start_pos": 60, "end_pos": 60, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q56JW4", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ], "site_lbl": "Tyr60" }, { "start_pos": 66, "end_pos": 66, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q56JW4", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ], "site_lbl": "Ser66" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:519017", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519017", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-BTA-74217", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-74217", "resource": "Reactome", "description": "Purine salvage" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7FV90-1", "protein_name": "Adenine phosphoribosyltransferase", "gene_name": "Aprt", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAESELQLVAQRIRSFPDFPIPGVLFRDISPLLKDPASFRASIRLLASHLKSTHGGKIDYIAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTVSASYALEYGKAELEIQKDALEPGQKVVVVDDLLATGGTMCAACELLGQLQAEVVECVSLVELTSLKGREKLGSVPFFSLLQYE", "length": 180 }, "evidence": [ { "id": "Q56JW4", "url": "https://omabrowser.org/oma/group/Q56JW4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P07741-1", "protein_name": "Adenine phosphoribosyltransferase", "gene_name": "APRT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADSELQLVEQRIRSFPDFPTPGVVFRDISPVLKDPASFRAAIGLLARHLKATHGGRIDYIAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTLWASYSLEYGKAELEIQKDALEPGQRVVVVDDLLATGGTMNAACELLGRLQAEVLECVSLVELTSLKGREKLAPVPFFSLLQYE", "length": 180 }, "evidence": [ { "id": "Q56JW4", "url": "https://omabrowser.org/oma/group/Q56JW4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P08030-1", "protein_name": "Adenine phosphoribosyltransferase", "gene_name": "Aprt", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSEPELKLVARRIRSFPDFPIPGVLFRDISPLLKDPDSFRASIRLLASHLKSTHSGKIDYIAGLDSRGFLFGPSLAQELGVGCVLIRKQGKLPGPTVSASYSLEYGKAELEIQKDALEPGQRVVIVDDLLATGGTMFAACDLLHQLRAEVVECVSLVELTSLKGRERLGPIPFFSLLQYD", "length": 180 }, "evidence": [ { "id": "Q56JW4", "url": "https://omabrowser.org/oma/group/Q56JW4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P12426-1", "protein_name": "Adenine phosphoribosyltransferase", "gene_name": "Aprt", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSPSISAEDKLDYVKSKIGEYPNFPKEGILFRDIFGALTDPKACVYLRDLLVDHIRESAPEAEVIVGLDSRGFLFNLLIATELGLGCAPIRKKGKLAGEVVSVEYKLEYGIDTFELQKSAIKPGQKVVVVDDLLATGGSLVAATELIGKVGGVVVESLVVMELVGLEGRKRLDGKVHSLIKY", "length": 182 }, "evidence": [ { "id": "Q56JW4", "url": "https://omabrowser.org/oma/group/Q56JW4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P36972-1", "protein_name": "Adenine phosphoribosyltransferase", "gene_name": "Aprt", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSESELQLVARRIRSFPDFPIPGVLFRDISPLLKDPDSFRASIRLLAGHLKSTHGGKIDYIAGLDSRGFLFGPSLAQELGVGCVLIRKRGKLPGPTVSASYSLEYGKAELEIQKDALEPGQKVVIVDDLLATGGTMCAACELLSQLRAEVVECVSLVELTSLKGREKLGPVPFFSLLQYE", "length": 180 }, "evidence": [ { "id": "Q56JW4", "url": "https://omabrowser.org/oma/group/Q56JW4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P36973-1", "protein_name": "Adenine phosphoribosyltransferase 2", "gene_name": "APT2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSISESYAKEIKTAFRQFTDFPIEGEQFEDFLPIIGNPTLFQKLVHTFKTHLEEKFGKEKIDFIAGIEARGLLFGPSLALALGVGFVPIRRVGKLPGECASITFTKLDHEEIFEMQVEAIPFDSNVVVVDDVLATGGTAYAAGDLIRQVGAHILEYDFVLVLDSLHGEEKLSAPIFSILHS", "length": 181 }, "evidence": [ { "id": "Q56JW4", "url": "https://omabrowser.org/oma/group/Q56JW4/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P47952-1", "protein_name": "Adenine phosphoribosyltransferase", "gene_name": "APRT", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAESELQLVAQRIRSFPDFPIPGVLFRDISPLLKDPASFRASIRLLASHLKSTHGGKIDYIAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTVSASYALEYGKAELEIQKDALEPGQKVVVVDDLLATGGTMCAACELLGQLQAEVVECVSLVELTSLKGREKLGSVPFFSLLQYE", "length": 180 }, "evidence": [ { "id": "Q56JW4", "url": "https://omabrowser.org/oma/group/Q56JW4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q55C82-1", "protein_name": "Probable adenine phosphoribosyltransferase", "gene_name": "aprt", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MQESKYQELQKQAEKSVKESMTLFQDWPNKGVGFQDISNLFLCYDKFSDVLDYYEHRFSDVDLVVGLEARGFILGTAFAQRMKLPMMMIRKKGKLPGPCFRESYKKEYGTDEFEVQEKALSKVVVKPSKKYHVLIMDDILAPGGTMAASIELTKKVLINNGIKDFKISTSLISSIKVLNGKEKIYEKYNDVSVDIIIEM", "length": 199 }, "evidence": [ { "id": "Q56JW4", "url": "https://omabrowser.org/oma/group/Q56JW4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9SUW2-1", "protein_name": "Adenine phosphoribosyltransferase 3", "gene_name": "APT3", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSGNKEEEDPRIHGIKTKIRVVPDFPKKGIMFQDITTVLLDPKAFKDTIDLFVERYRDKNISVVAGIEARGFLFGPPIALAIGAKFVPLRKPKKLPGETIFEEYELEYGNDRLEMHIGAVEAGDRALVVDDLIATGGTLCAAINLLERVGAEVVECACVIELPELKGRQRLKGKPLCMLVEYR", "length": 183 }, "evidence": [ { "id": "Q56JW4", "url": "https://omabrowser.org/oma/group/Q56JW4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q56JW4", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q56JW4", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "AMP binding", "id": "GO:0016208", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016208", "evidence": [ { "database": "UniProtKB", "id": "Q56JW4", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ], "pmid": "" }, { "name": "adenine binding", "id": "GO:0002055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002055", "evidence": [ { "database": "UniProtKB", "id": "Q56JW4", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ], "pmid": "" }, { "name": "adenine phosphoribosyltransferase activity", "id": "GO:0003999", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003999", "evidence": [ { "database": "UniProtKB", "id": "Q56JW4", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "AMP salvage", "id": "GO:0044209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044209", "evidence": [ { "database": "UniProtKB", "id": "Q56JW4", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ], "pmid": "" }, { "name": "purine ribonucleoside salvage", "id": "GO:0006166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006166", "evidence": [ { "database": "UniProtKB", "id": "Q56JW4", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ], "pmid": "" }, { "name": "adenine salvage", "id": "GO:0006168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006168", "evidence": [ { "database": "UniProtKB", "id": "Q56JW4", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ], "pmid": "" }, { "name": "IMP salvage", "id": "GO:0032264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032264", "evidence": [ { "database": "UniProtKB", "id": "Q56JW4", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16609", "name": "", "equation": "AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q56JW4-1" ], "evidence": [ { "id": "16609", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16609" } ] }, { "id": "R-BTA-6798748", "name": "Exocytosis of secretory granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, secretory granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P19120-1", "P68401-1", "A0JNA3-1", "F1MMD5-1", "A0AAA9S4U4-1", "P80177-1", "Q0II59-1", "Q0VCM4-1", "Q3SWY3-1", "Q3SYU2-1", "F1MHT1-1", "A0AAA9RV00-1", "A0ABI0P3F2-1", "P62935-1", "P68103-1", "Q3T0Q4-1", "A0A452DJA8-1", "E1BNY9-1", "A0A3Q1LMV5-1", "A0A3Q1LTT9-1", "A1A4J1-1", "F1MQ78-1", "G3X757-1", "P00432-1", "Q76LV2-1", "A0A140T8A5-1", "A0A3Q1LR63-1", "Q56JW4-1", "Q3T0A3-1", "Q3ZBD7-1", "Q58DK5-1", "Q3SZ62-1", "Q3T0V9-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6798748", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798748" } ] }, { "id": "R-BTA-74213", "name": "APRT catalyzes the conversion of adenine to AMP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-83951", "R-ALL-73566" ], "output_participant_list": [], "enzyme_list": [ "Q56JW4-1" ], "evidence": [ { "id": "R-BTA-74213", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-74213" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-73566", "participant_name": "PRPP [cytosol]", "crossref": [ { "id": "58017", "database": "ChEBI", "url": "" }, { "id": "ZINC000008215630", "database": "ZINC", "url": "" }, { "id": "C00119", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-83951", "participant_name": "Ade [cytosol]", "crossref": [ { "id": "16708", "database": "ChEBI", "url": "" }, { "id": "C00147", "database": "COMPOUND", "url": "" }, { "id": "8144939", "database": "PubChem Substance", "url": "" }, { "id": "4788", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "ZINC000000000882", "database": "ZINC", "url": "" }, { "id": "HMDB0000034", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A140T8A5", "gene_name": "IDH1", "activity": [ { "ec_number": "1.1.1.42", "activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] }, { "ec_number": "1.1.1.42", "activity": "", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] } ] }, { "uniprot_ac": "A0A3Q1LMV5", "gene_name": "LOC281806", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] } ] }, { "uniprot_ac": "A0A3Q1LR63", "gene_name": "HK3", "activity": [ { "ec_number": "2.7.1.1", "activity": "D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR63" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR63" } ] } ] }, { "uniprot_ac": "A0A3Q1LTT9", "gene_name": "MAPK14", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LTT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT9" } ] } ] }, { "uniprot_ac": "A0A452DJA8", "gene_name": "PNP", "activity": [ { "ec_number": "2.4.2.1", "activity": "adenosine + phosphate = alpha-D-ribose 1-phosphate + adenine.", "evidence": [ { "id": "A0A452DJA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DJA8" } ] }, { "ec_number": "2.4.2.1", "activity": "", "evidence": [ { "id": "A0A452DJA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DJA8" } ] } ] }, { "uniprot_ac": "A0AAA9RV00", "gene_name": "PPIE", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0AAA9RV00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV00" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0AAA9RV00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV00" } ] } ] }, { "uniprot_ac": "A0AAA9S4U4", "gene_name": "ALDOC", "activity": [ { "ec_number": "4.1.2.13", "activity": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate.", "evidence": [ { "id": "A0AAA9S4U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4U4" } ] }, { "ec_number": "4.1.2.13", "activity": "", "evidence": [ { "id": "A0AAA9S4U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4U4" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0JNA3", "gene_name": "IMPDH1", "activity": [ { "ec_number": "1.1.1.205", "activity": "IMP + NAD(+) + H2O = XMP + NADH + H(+).", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] } ] }, { "uniprot_ac": "A1A4J1", "gene_name": "PFKL", "activity": [ { "ec_number": "2.7.1.11", "activity": "beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+).", "evidence": [ { "id": "A1A4J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4J1" } ] }, { "ec_number": "2.7.1.11", "activity": "", "evidence": [ { "id": "A1A4J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4J1" } ] } ] }, { "uniprot_ac": "E1BNY9", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] } ] }, { "uniprot_ac": "F1MHT1", "gene_name": "AGL", "activity": [ { "ec_number": "2.4.1.25", "activity": "Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan.", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] }, { "ec_number": "3.2.1.33", "activity": "Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] }, { "ec_number": "3.2.1.33", "activity": "", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] }, { "ec_number": "2.4.1.25", "activity": "", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MQ78", "gene_name": "ALOX5", "activity": [ { "ec_number": "1.13.11.34", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = leukotriene A4 + H2O.", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] }, { "ec_number": "1.13.11.12", "activity": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate.", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] }, { "ec_number": "1.13.11.34", "activity": "", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] }, { "ec_number": "1.13.11.12", "activity": "", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "P00432", "gene_name": "CAT", "activity": [ { "ec_number": "1.11.1.6", "activity": "2 H2O2 = O2 + 2 H2O.", "evidence": [ { "id": "P00432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00432" } ] }, { "ec_number": "1.11.1.6", "activity": "", "evidence": [ { "id": "P00432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00432" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P62935", "gene_name": "PPIA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P62935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62935" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P62935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62935" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P68401", "gene_name": "PAFAH1B2P68402", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P68401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68401" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "P68401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68401" } ] } ] }, { "uniprot_ac": "P80177", "gene_name": "MIF", "activity": [ { "ec_number": "5.3.2.1", "activity": "3-phenylpyruvate = enol-phenylpyruvate.", "evidence": [ { "id": "P80177", 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"UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATKPKLHYPNGRGRMESVRWVLAAAGVEFDEEFLETKEQLQKLQDGNHLLFQQVPMVEIDGMKLVQTRSILHYIADKHHLFGKDLKERTLIDMYVEGTLDLLELLIMHPFLKPDDQQKEVANMAQKAIIRYFPVFEKVLRGHGQRFLVGNQLSLADIILLQTILALEEKIPNILSAFPHLQEYTVKISNIPTIKKFLEPGSKKKPPPDDIYVRTVYNIFMP", "length": 222, "header": "sp|Q5E9G0-1|GSTA4_BOVIN Isoform 1 of Glutathione S-transferase A4 OS=Bos taurus OX=9913 GN=GSTA4 PE=2 SV=1 CANONICAL=Q5E9G0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LT12-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9G0/entry#A0A3Q1LT12-1", "sequence": { "sequence": "MSRKTGARQVMKTTEREPQRQKVCPPNWLPNLRILEELKKNSSGGWKECRPFVYCRVSHILDTPPSHLAAPSRLNWLGCCFCRSLYLHCPSRERGMPQGGPSGELSLTTWFDEEFLETKEQLQKLQDGNHLLFQQVPMVEIDGMKLVQTRSILHYIADKHHLFGKDLKERTLIDMYVEGTLDLLELLIMHPFLKPDDQQKEVANMAQKAIIRYFPVFEKVLRGHGQRFLVGNQLSLADIILLQTILALEEKIPNILSAFPHLQEYTVKISNIPTIKKFLEPGSKKKPPPDDIYVRTVYNIFMP", "length": 303, "header": "tr|A0A3Q1LT12-1|GSTA4_BOVIN Computationally mapped isoform of Glutathione S-transferase A4 OS=Bos taurus OX=9913 GN=GSTA4 PE=2 SV=1 CANONICAL=Q5E9G0-1" }, "locus": { "chromosome": "23", "start_pos": 25218253, "end_pos": 25210309, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069040.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069040.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063570.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063570.1" } ] } }, { "isoform_ac": "A0A3Q1M0K8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9G0/entry#A0A3Q1M0K8-1", "sequence": { "sequence": "MLNIAVSIGEIFWSLAHRRPRVPRLQTARWAPLCGSGHSEWSQFDEEFLETKEQLQKLQDGNHLLFQQVPMVEIDGMKLVQTRSILHYIADKHHLFGKDLKERTLIDMYVEGTLDLLELLIMHPFLKPDDQQKEVANMAQKAIIRYFPVFEKVLRGHGQRFLVGNQLSLADIILLQTILALEEKIPNILSAFPHLQEYTVKISNIPTIKKFLEPGSKKKPPPDDIYVRTVYNIFMP", "length": 236, "header": "tr|A0A3Q1M0K8-1|GSTA4_BOVIN Computationally mapped isoform of Glutathione S-transferase A4 OS=Bos taurus OX=9913 GN=GSTA4 PE=2 SV=1 CANONICAL=Q5E9G0-1" }, "locus": { "chromosome": "23", "start_pos": 25224018, "end_pos": 25210309, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085668.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085668.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061522.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061522.1" } ] } }, { "isoform_ac": "A0A3Q1MHS2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9G0/entry#A0A3Q1MHS2-1", "sequence": { "sequence": "MRHHGHMTSTCLVFSVAECDHCVSLTSACSHSMKFSSVTLSATVFAALIITVVRGYKMFDEEFLETKEQLQKLQDGNHLLFQQVPMVEIDGMKLVQTRSILHYIADKHHLFGKDLKERTLIDMYVEGTLDLLELLIMHPFLKPDDQQKEVANMAQKAIIRYFPVFEKVLRGHGQRFLVGNQLSLADIILLQTILALEEKIPNILSAFPHLQEYTVKISNIPTIKKFLEPGSKKKPPPDDIYVRTVYNIFMP", "length": 251, "header": "tr|A0A3Q1MHS2-1|GSTA4_BOVIN Computationally mapped isoform of Glutathione S-transferase A4 OS=Bos taurus OX=9913 GN=GSTA4 PE=2 SV=1 CANONICAL=Q5E9G0-1" }, "locus": { "chromosome": "23", "start_pos": 25222150, "end_pos": 25210309, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074785.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074785.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073828.1", "url": "https://www.ensembl.org/id/ENSBTAP00000073828.1" } ] } }, { "isoform_ac": "A0AAA9SMF6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9G0/entry#A0AAA9SMF6-1", "sequence": { "sequence": "MLGGTEGRRRRGRQRMRWLDGITDSMDFDEEFLETKEQLQKLQDGNHLLFQQVPMVEIDGMKLVQTRSILHYIADKHHLFGKDLKERTLIDMYVEGTLDLLELLIMHPFLKPDDQQKEVANMAQKAIIRYFPVFEKVLRGHGQRFLVGNQLSLADIILLQTILALEEKIPNILSAFPHLQEYTVKISNIPTIKKFLEPGSKKKPPPDDIYVRTVYNIFMP", "length": 220, "header": "tr|A0AAA9SMF6-1|GSTA4_BOVIN Computationally mapped isoform of Glutathione S-transferase A4 OS=Bos taurus OX=9913 GN=GSTA4 PE=2 SV=1 CANONICAL=Q5E9G0-1" }, "locus": { "chromosome": "23", "start_pos": 25217485, "end_pos": 25210309, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112243.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112243.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085114.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085114.1" } ] } }, { "isoform_ac": "Q5E9G0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9G0/entry#Q5E9G0-1", "sequence": { "sequence": "MATKPKLHYPNGRGRMESVRWVLAAAGVEFDEEFLETKEQLQKLQDGNHLLFQQVPMVEIDGMKLVQTRSILHYIADKHHLFGKDLKERTLIDMYVEGTLDLLELLIMHPFLKPDDQQKEVANMAQKAIIRYFPVFEKVLRGHGQRFLVGNQLSLADIILLQTILALEEKIPNILSAFPHLQEYTVKISNIPTIKKFLEPGSKKKPPPDDIYVRTVYNIFMP", "length": 222, "header": "sp|Q5E9G0-1|GSTA4_BOVIN Isoform 1 of Glutathione S-transferase A4 OS=Bos taurus OX=9913 GN=GSTA4 PE=2 SV=1 CANONICAL=Q5E9G0-1" }, "locus": { "chromosome": "23", "start_pos": 25222914, "end_pos": 25210309, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028640.6", "url": "https://www.ensembl.org/id/ENSBTAT00000028640.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028640.4", "url": "https://www.ensembl.org/id/ENSBTAP00000028640.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G0", "url": "https://www.uniprot.org/uniprotkb/Q5E9G0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "Evaluation of GSTP1, GSTA4 and AChE Gene Methylation in Bovine Lymphocytes Cultured In Vitro with Miconazole Alone and in Combination with Mospilan 20SP.", "journal": "Genes", "date": "2023-09-12", "authors": "Halu\u0161kov\u00e1 Jana, Hole\u010dkov\u00e1 Be\u00e1ta, Schwarzbacherov\u00e1 Viera, Gald\u00edkov\u00e1 Martina, Sedl\u00e1kov\u00e1 Silvia, Bu\u010dan Jaroslav", "evidence": [ { "database": "RefSeq", "id": "NP_001015651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015651" } ], "reference": [ { "type": "PubMed", "id": "37761931", "url": "https://glygen.org/publication/PubMed/37761931" } ] } ], "pathway": [ { "id": "bta:533917", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533917", "resource": "KEGG Pathway" }, { "id": "R-BTA-156590", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156590", "resource": "Reactome", "description": "Glutathione conjugation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1TD81-1", "protein_name": "glutathione transferase", "gene_name": "GSTA4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMATKPKLHYPNGRGRMESVRWVLAAAGVEFDEEFLETKEQLQKLQDGNHLLFQQVPMVEIDGMKLVQTRSILHYIADKHHLFGKDLKERTLIDMYVEGTLDLLELIIMHPFLKPDDQQKEVVNMAQKAIIRYFPVFEKVLRGHGQRFLVGNQLSLADIILLQTILALEEKIPNILSAFPHLQEFTVKISNIPTIKKFLEPGSKKKPPPDDIYVRTVYNIFMP", "length": 223 }, "evidence": [ { "id": "Q5E9G0", "url": "https://omabrowser.org/oma/group/Q5E9G0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O15217-1", "protein_name": "Glutathione S-transferase A4", "gene_name": "GSTA4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAARPKLHYPNGRGRMESVRWVLAAAGVEFDEEFLETKEQLYKLQDGNHLLFQQVPMVEIDGMKLVQTRSILHYIADKHNLFGKNLKERTLIDMYVEGTLDLLELLIMHPFLKPDDQQKEVVNMAQKAIIRYFPVFEKILRGHGQSFLVGNQLSLADVILLQTILALEEKIPNILSAFPFLQEYTVKLSNIPTIKRFLEPGSKKKPPPDEIYVRTVYNIFRP", "length": 222 }, "evidence": [ { "id": "Q5E9G0", "url": "https://omabrowser.org/oma/group/Q5E9G0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "glutathione transferase activity", "id": "GO:0004364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004364", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G0", "url": "https://www.uniprot.org/uniprotkb/Q5E9G0" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G0", "url": "https://www.uniprot.org/uniprotkb/Q5E9G0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G0", "url": "https://www.uniprot.org/uniprotkb/Q5E9G0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G0", "url": "https://www.uniprot.org/uniprotkb/Q5E9G0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "xenobiotic metabolic process", "id": "GO:0006805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G0", "url": "https://www.uniprot.org/uniprotkb/Q5E9G0" } ], "pmid": "" }, { "name": "glutathione metabolic process", "id": "GO:0006749", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006749", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G0", "url": "https://www.uniprot.org/uniprotkb/Q5E9G0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16437", "name": "", "equation": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O18879-1", "F1MUX5-1", "F1MX44-1", "A0ABI0P5M0-1", "A0AAA9TW47-1", "F6QEM8-1", "A0ABI0P3R2-1", "A0AAF6Z0W3-1", "P28801-1", "Q2KJG4-1", "A0A3Q1LMV5-1", "F1MVX2-1", "Q28035-1", "Q9N0V4-1", "Q2NL00-1", "F1MXY2-1", "E1BED9-1", "A0ABI0P006-1", "Q5E9G0-1", "Q64L89-1", "A0A452DIU1-1", "F1MGZ9-1", "A0AAA9TXU3-1", "E1BJX2-1" ], "evidence": [ { "id": "16437", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16437" } ] }, { "id": "R-BTA-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O18879-1", "E1BED9-1", "A0ABI0P006-1", "A0ABI0P5M0-1", "A0A3Q1LMV5-1", "F1MGZ9-1", "F1MUX5-1", "F1MX44-1", "Q2NL00-1", "Q5E9G0-1", "A0A452DIU1-1" ], "evidence": [ { "id": "R-BTA-176054", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176054" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LMV5", "gene_name": "LOC281806", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] } ] }, { "uniprot_ac": "A0A452DIU1", "gene_name": "LOC327709", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0A452DIU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DIU1" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0A452DIU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DIU1" } ] } ] }, { "uniprot_ac": "A0AAA9TW47", "gene_name": "GSTK1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0AAA9TW47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW47" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0AAA9TW47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW47" } ] } ] }, { "uniprot_ac": "A0AAA9TXU3", "gene_name": "GSTZ1", "activity": [ { "ec_number": "5.2.1.2", "activity": "4-maleylacetoacetate = 4-fumarylacetoacetate.", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] }, { "ec_number": "5.2.1.2", "activity": "", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] } ] }, { "uniprot_ac": "A0AAF6Z0W3", "gene_name": "LANCL1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": 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Its alpha-2,3-sialyltransferase activity is specific toward type II glycan chains (Galbeta1-4GlcNAc) on glycoproteins and glycolipids such as neolactosides nLc4Cer and nLc6Cer, whose sialyl-products serve as precursors for the Lewis X antigen. Critically involved in the synthesis of functional selectin ligands needed for neutrophil recruitment during inflammation and lymphocyte homing to the lymph nodes.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVL5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVL5#function" }, { "database": "UniProtKB", "id": "ARBA00094121", "url": "https://www.uniprot.org/uniprotkb/ARBA00094121#function" }, { "database": "UniProtKB", "id": "A0AAF6ZZ52", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZZ52#function" }, { "database": "UniProtKB", "id": "Q6H8M7", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7#function" }, { "database": "UniProtKB", "id": "Q8VIB3", "url": "https://www.uniprot.org/uniprotkb/Q8VIB3#function" }, { "database": "UniProtKB", "id": "Q9Y274", "url": "https://www.uniprot.org/uniprotkb/Q9Y274#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6H8M7", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ST3GAL6", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7", "locus": { "chromosome": "1", "start_pos": 43111603, "end_pos": 43047976, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004471", "url": "https://www.ensembl.org/id/ENSBTAG00000004471" } ] } } ], "crossref": [ { "id": "Q6H8M7", "url": "https://alphafold.ebi.ac.uk/entry/Q6H8M7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004471", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004471", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23984", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23984", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "444860", "url": "https://www.ncbi.nlm.nih.gov/gene/444860", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012163", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051142", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051142", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:444860", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:444860", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LAFHICS", "url": "https://omabrowser.org/oma/group/LAFHICS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LVL5", "url": "https://www.orthodb.org/?gene=A0A3Q1LVL5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q6H8M7", "url": "https://www.orthodb.org/?gene=Q6H8M7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13713", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13713", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13713:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13713:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00777", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00777", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2022854", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022854", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4085001", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4085001", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9037629", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9037629", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001002883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002883", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "18913", "url": "https://www.rhea-db.org/rhea/18913", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "52316", "url": "https://www.rhea-db.org/rhea/52316", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "80751", "url": "https://www.rhea-db.org/rhea/80751", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LVL5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVL5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVL5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZZ52", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZZ52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZZ52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZZ52-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6H8M7", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6H8M7-1", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGYLLAIFLSAVFLYYVLHCILWRTNDYGVTPMEMKQRNKIRSCLSKPAFASLLRYHQFHPFLCAANFKNTASFYGSDKFDLPYGMKASATHFRLALWKLPNCDIFDEFDNVPCKKCVVVGNGGILKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPNHNDPNTTVILTAFKPLDLKWLWELLTGGKISPNGFWKEPALNLIYKPYQIRILDPYITRMAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFHICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMSENEYHNVTAEQLFLKDIIEKNFVTDLTQE", "length": 331, "header": "sp|Q6H8M7-1|SIA10_BOVIN Isoform 1 of Type 2 lactosamine alpha-2,3-sialyltransferase OS=Bos taurus OX=9913 GN=ST3GAL6 PE=2 SV=1 CANONICAL=Q6H8M7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVL5-1", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7/entry#A0A3Q1LVL5-1", "sequence": { "sequence": "MRGYLLAIFLSAVFLYYVLHCILWRTNDYGVTPMEMKQRNKIRSCLSKPAFASLLRYHQFHPFLCAANFKNTASFYGSDKFDLPYGMKASGQCLKLSLIYLFNSVPCKKCVVVGNGGILKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPNHNDPNTTVILTAFKPLDLKWLWELLTGGKISPNGFWKEPALNLIYKPYQIRILDPYITRMAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFHICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMSENEYHNVTAEQLFLKDIIEKNFVTDLTQE", "length": 323, "header": "tr|A0A3Q1LVL5-1|SIA10_BOVIN Computationally mapped isoform of Type 2 lactosamine alpha-2,3-sialyltransferase OS=Bos taurus OX=9913 GN=ST3GAL6 PE=2 SV=1 CANONICAL=Q6H8M7-1" }, "locus": { "chromosome": "1", "start_pos": 43108334, "end_pos": 43066223, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082869.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082869.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059361.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059361.1" } ] } }, { "isoform_ac": "A0AAF6ZZ52-1", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7/entry#A0AAF6ZZ52-1", "sequence": { "sequence": "MRGYLLAIFLSAVFLYYVLHCILWRTNDYGVTPMEMKQRNKIRSCLSKPAFASLLRYHQFHPFLCAANFKNTASFYGSDKFDLPYGMKASATHFRLALWKLPNCDIFDEFDKMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPNHNDPNTTVILTAFKPLDLKWLWELLTGGKISPNGFWKEPALNLIYKPYQIRILDPYITRMAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFHICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMSENEYHNVTAEQLFLKDIIEKNFVTDLTQE", "length": 299, "header": "tr|A0AAF6ZZ52-1|SIA10_BOVIN Computationally mapped isoform of Type 2 lactosamine alpha-2,3-sialyltransferase OS=Bos taurus OX=9913 GN=ST3GAL6 PE=2 SV=1 CANONICAL=Q6H8M7-1" }, "locus": { "chromosome": "1", "start_pos": 43108334, "end_pos": 43066223, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069771.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069771.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059813.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059813.2" } ] } }, { "isoform_ac": "Q6H8M7-1", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7/entry#Q6H8M7-1", "sequence": { "sequence": "MRGYLLAIFLSAVFLYYVLHCILWRTNDYGVTPMEMKQRNKIRSCLSKPAFASLLRYHQFHPFLCAANFKNTASFYGSDKFDLPYGMKASATHFRLALWKLPNCDIFDEFDNVPCKKCVVVGNGGILKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPNHNDPNTTVILTAFKPLDLKWLWELLTGGKISPNGFWKEPALNLIYKPYQIRILDPYITRMAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFHICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMSENEYHNVTAEQLFLKDIIEKNFVTDLTQE", "length": 331, "header": "sp|Q6H8M7-1|SIA10_BOVIN Isoform 1 of Type 2 lactosamine alpha-2,3-sialyltransferase OS=Bos taurus OX=9913 GN=ST3GAL6 PE=2 SV=1 CANONICAL=Q6H8M7-1" }, "locus": { "chromosome": "1", "start_pos": 43108334, "end_pos": 43066223, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005868.5", "url": "https://www.ensembl.org/id/ENSBTAT00000005868.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005868.3", "url": "https://www.ensembl.org/id/ENSBTAP00000005868.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 129, "start_aa": "Asn", "end_pos": 129, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn129", "evidence": [ { "id": "Q6H8M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 181, "start_aa": "Asn", "end_pos": 181, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn181", "evidence": [ { "id": "Q6H8M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 282, "start_aa": "Asn", "end_pos": 282, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn282", "evidence": [ { "id": "Q6H8M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 295, "start_aa": "Asn", "end_pos": 295, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn295", "evidence": [ { "id": "Q6H8M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 308, "start_aa": "Asn", "end_pos": 308, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn308", "evidence": [ { "id": "Q6H8M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycosyltransferase-activity", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach.", "journal": "Glycobiology", "date": "2005", "authors": "Harduin-Lepers A, Mollicone R, Delannoy P, Oriol R", "evidence": [ { "database": "UniProtKB", "id": "Q6H8M7", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7" } ], "reference": [ { "type": "PubMed", "id": "15843597", "url": "https://glygen.org/publication/PubMed/15843597" } ] } ], "pathway": [ { "id": "bta:444860", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:444860", "resource": "KEGG Pathway" }, { "id": "R-BTA-2022854", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022854", "resource": "Reactome", "description": "Keratan sulfate biosynthesis" }, { "id": "R-BTA-4085001", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4085001", "resource": "Reactome", "description": "Sialic acid metabolism" }, { "id": "R-BTA-9037629", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9037629", "resource": "Reactome", "description": "Lewis blood group biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XRF2-1", "protein_name": "Type 2 lactosamine alpha-2,3-sialyltransferase", "gene_name": "ST3GAL6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MALDYERYREQQLQLLFDPAGRHALARGKKVLMPVAESLERRPSCYFFPDLLLLLENSKLYWKLRNPFFLWEMTISSQSNWDAVEVNGLPVMKRILLFFILAAAVMYGILHGNLWRNNFYWLPPTAVERRNALNTCTLKPAFESLLDVEKIYPFLCASDFIRVAEYHGSDKFELPYGIKRAEQFFRSALSKLQNCGLSNKDDTVACRRCVVVGNGGVLRNKTLGGKIDSYDVIIRMNNGPVIGYEEDVGRRTTFRLSYPESIFSDPIHYDPNTTVVIIVFKPRDLKWLWEILGGQKISAKGFWKKPALNMIYKSNQIRILDPSITRKTAYDWLHFPTRFPKKEKPKHPTTGLIAITLAFHICHEVHLAGFKYDFTDRNSSLHYYGNETMSQMMQNEYHDISAEQKFLKKLIDKNFVVNLT", "length": 420 }, "evidence": [ { "id": "Q6H8M7", "url": "https://omabrowser.org/oma/group/Q6H8M7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7JP86-1", "protein_name": "Type 2 lactosamine alpha-2,3-sialyltransferase", "gene_name": "St3gal6", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLPINFHPTLLRLSEREDLRETHPRSAGRPTMRGYQVALVLCSIFLYYLLHCLLWGTNVFWLPTAEIKNKNIKRCPKQPPFASLLKFPQFYPFLCAADFTKTTSKYGTSDFALPYGTRPSGIHFRWVLSKLQNCALFDEFDKVPCKRCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEDVGRRTTFRLFYPESVFSDPAHNDHNSTAVFIVFKPQDLLWLLNIMKGNKINTNGFWKMPALNLIYKRYQIRILDPYIIREAAYNLLQIPKVFPKNQKPKHPTTGIIAITLAFHICSEVHLAGFKYNFNNPNSSLHYYGNATMSLMKQNAYHNVTAEQLFLTSIIEKNMVINLTED", "length": 361 }, "evidence": [ { "id": "Q6H8M7", "url": "https://omabrowser.org/oma/group/Q6H8M7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P61943-1", "protein_name": "Type 2 lactosamine alpha-2,3-sialyltransferase", "gene_name": "St3gal6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKGYVVAIFLSSIFLYYVLYCILWGTNGYWFPNEEMKSKNNVKNCFKKPAFASLLRFPQFYPFLCKADFVKVAATYGTNNFLLPYGVKTFESYFRSGLSKLQSCDLVGQFDTVPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPSHYDPNTTAVLVVFKPQDLRWLMEILIGKKINTDGFWKKPALKLIYKQYQIRILDPYIIREAAFQLLRFPRVFPKDQKPKHPTTGIIALTLAFHICSEVHLAGFKYNFYTPDSPLHYYGNATMSLMKKNAYHNLTAEQLFLKNLIKKKMVINLTQN", "length": 331 }, "evidence": [ { "id": "Q6H8M7", "url": "https://omabrowser.org/oma/group/Q6H8M7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VIB3-1", "protein_name": "Type 2 lactosamine alpha-2,3-sialyltransferase", "gene_name": "St3gal6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGYLVAIFLSSIFLYYVLYCILWGTNGYWFPAEEMRTRNNVNNCFKKPAFANLLRFPQLYPFLCRADFIKVAAMSGTNNFPLPYGIKTFETYFSSALSKLQSCDLFDEFDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSSHYDPNTTAVLVVFKPQDLRWLVEILLGKKINTQGFWKTPALKLIYKQYQIRILDPYITSEAAFQMLRFPRVFPKDQKPKHPTTGIIAITMAFHICSEVHLAGFKYNFYSPNSPLHYYGNATMSLMKQNAYHNLTAEQLFLNDIIKKKMVINLT", "length": 329 }, "evidence": [ { "id": "Q6H8M7", "url": "https://omabrowser.org/oma/group/Q6H8M7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y274-1", "protein_name": "Type 2 lactosamine alpha-2,3-sialyltransferase", "gene_name": "ST3GAL6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRGYLVAIFLSAVFLYYVLHCILWGTNVYWVAPVEMKRRNKIQPCLSKPAFASLLRFHQFHPFLCAADFRKIASLYGSDKFDLPYGMRTSAEYFRLALSKLQSCDLFDEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHDLRWLLELLMGDKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDIIEKNLVINLTQD", "length": 331 }, "evidence": [ { "id": "Q6H8M7", "url": "https://omabrowser.org/oma/group/Q6H8M7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q6H8M7", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "glycoprotein biosynthetic process", "id": "GO:0009101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009101", "evidence": [ { "database": "UniProtKB", "id": "Q6H8M7", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7" } ], "pmid": "" }, { "name": "glycolipid biosynthetic process", "id": "GO:0009247", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009247", "evidence": [ { "database": "UniProtKB", "id": "Q6H8M7", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7" } ], "pmid": "" }, { "name": "cellular response to interleukin-6", "id": "GO:0071354", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071354", "evidence": [ { "database": "UniProtKB", "id": "Q6H8M7", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "sialyltransferase activity", "id": "GO:0008373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008373", "evidence": [ { "database": "UniProtKB", "id": "Q6H8M7", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7" } ], "pmid": "" }, { "name": "N-acetyllactosaminide alpha-2,3-sialyltransferase activity", "id": "GO:0008118", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008118", "evidence": [ { "database": "UniProtKB", "id": "Q6H8M7", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" }, { "start_pos": 181, "end_pos": 183, "annotation": "n_glycosylation_sequon" }, { "start_pos": 282, "end_pos": 284, "annotation": "n_glycosylation_sequon" }, { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" }, { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "18913", "name": "", "equation": "a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6H8M7-1", "A0AAA9TT54-1" ], "evidence": [ { "id": "18913", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/18913" } ] }, { "id": "52316", "name": "", "equation": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6H8M7-1", "A0AAA9TT54-1", "F1MZD3-1" ], "evidence": [ { "id": "52316", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52316" } ] }, { "id": "80751", "name": "", "equation": "a neolactoside nLc6Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a neolactoside VI(3)-alpha-NeuNAc-nLc6Cer(d18:1(4E)) + CMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6H8M7-1" ], "evidence": [ { "id": "80751", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/80751" } ] }, { "id": "R-BTA-2046285", "name": "ST3GAL1-4,6 optionally cap keratan chain", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MZD3-1", "Q6H8M7-1" ], "evidence": [ { "id": "R-BTA-2046285", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2046285" } ] }, { "id": "R-BTA-4084984", "name": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [ "R-ALL-727815", "R-ALL-4086285" ], "output_participant_list": [ "R-ALL-4086277", "R-ALL-727810" ], "enzyme_list": [ "A0A3Q1ML07-1", "F1MZD3-1", "Q6H8M7-1" ], "evidence": [ { "id": "R-BTA-4084984", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4084984" } ] }, { "id": "R-BTA-9605600", "name": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MZD3-1", "Q6H8M7-1" ], "evidence": [ { "id": "R-BTA-9605600", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9605600" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-4086277", "participant_name": "Neu5Ac-2,3-Gal-R [Golgi lumen]", "crossref": [ { "id": "75127", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-4086285", "participant_name": "Gal-R [Golgi lumen]", "crossref": [ { "id": "61248", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-727810", "participant_name": "CMP [Golgi lumen]", "crossref": [ { "id": "ZINC000003861744", "database": "ZINC", "url": "" }, { "id": "60377", "database": "ChEBI", "url": "" }, { "id": "C00055", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-727815", "participant_name": "CMP-Neu5Ac [Golgi lumen]", "crossref": [ { "id": "57812", "database": "ChEBI", "url": "" }, { "id": "ZINC000008215638", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1ML07", "gene_name": "ST3GAL5", "activity": [ { "ec_number": "2.4.3.9", "activity": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM3 (d18:1(4E)) + CMP + H(+).", "evidence": [ { "id": "A0A3Q1ML07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML07" } ] }, { "ec_number": "2.4.3.9", "activity": "", "evidence": [ { "id": "A0A3Q1ML07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML07" } ] } ] }, { "uniprot_ac": "A0AAA9TT54", "gene_name": "ST3GAL4", "activity": [ { "ec_number": "2.4.3.2", "activity": "a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a (d18:1(4E)) + CMP + H(+).", "evidence": [ { "id": "A0AAA9TT54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT54" } ] }, { "ec_number": "2.4.3.4", "activity": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "A0AAA9TT54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT54" } ] }, { "ec_number": "2.4.3.6", "activity": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "A0AAA9TT54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT54" } ] }, { "ec_number": "2.4.3.2", "activity": "", "evidence": [ { "id": "A0AAA9TT54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT54" } ] }, { "ec_number": "2.4.3.6", "activity": "", "evidence": [ { "id": "A0AAA9TT54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT54" } ] }, { "ec_number": "2.4.3.4", "activity": "", "evidence": [ { "id": "A0AAA9TT54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT54" } ] } ] }, { "uniprot_ac": "F1MZD3", "gene_name": "ST3GAL3", "activity": [ { "ec_number": "2.4.3.6", "activity": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "F1MZD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZD3" } ] }, { "ec_number": "2.4.3.6", "activity": "", "evidence": [ { "id": "F1MZD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZD3" } ] } ] }, { "uniprot_ac": "Q6H8M7", "gene_name": "ST3GAL6", "activity": [ { "ec_number": "2.4.3.6", "activity": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "Q6H8M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7" } ] }, { "ec_number": "2.4.3.6", "activity": "", "evidence": [ { "id": "Q6H8M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6H8M7" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q6H8M7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 331, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q6H8M7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q6H8M7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [ { "glytoucan_ac": "G00201AB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G00231WL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G00241VQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00320ZP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G00368HM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00420CS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00468NI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00531ZU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G00646SN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00662IB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00706AL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00728SN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00835TJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G00886GB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G00909PI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00923KH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G00948WV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G00978GW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01034MJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G01044XE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G01050GH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G01123UL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G01218JA", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G01244DB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G01310VF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G01354KL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G01375NQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G01406RR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G01437WY", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G01457KB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G01522FD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G01571OF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G01631SU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G01669LU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G01674VT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01701XV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G01734XU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G01789AQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G01827FA", "type": "N-linked", "subtype": 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"G03250UN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G03260OU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G03266UM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03325PY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G03345AP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G03385XG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G03393PF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G03414KZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G03479ZN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G03529DJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G03542LT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G03583SA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G03591CN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G03600YM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G03668AQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G03670RH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03708WQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G03754YM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G03895SR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G03912QC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G03948VT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G04023GJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G04163JP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G04214MY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G04241HQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G04273XP", "type": "N-linked", 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"G13382WY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G13412NN", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G13444XN", "type": "N-linked", "subtype": "Arm-fucosylated" }, { "glytoucan_ac": "G13495RN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G13496UJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13585JF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G13626CZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G13659RH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G14047PA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G14233VW", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G14393TF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G14428PM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G14431ZQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G14438ZT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G14690RN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G14722QE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14781HP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G14801HT", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G14867MM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G14899VS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G14920YO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G14942ZU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G14954HI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G14996IQ", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G14998UC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G15006PM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G15204IM", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G15220QC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15249CA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15303EK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G15306QC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G15318TJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G15355KC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G15530MC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G15571KX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G15648GT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G15696VL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G15717HW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G15730FJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G15794TC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G15821ZM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G15859AU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16028RM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G16038YA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16150CJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16155TD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16201LW", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G16294GR", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G16340ZJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G16341ZC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G16393FR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16397GM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G16403CC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16437LH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G16476DW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16510IU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16516HD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16529MG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16702HQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16705KA", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G16743OM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G16759KR", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G16774YZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G16782SL", "type": "N-linked", "subtype": "Tetraantennary" 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"subtype": "Triantennary" }, { "glytoucan_ac": "G17236US", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G17251XF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G17253JN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G17315BS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G17331IX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17348SA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G17389EH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G17431SG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G17441MI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G17473NR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G17527HL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G17539BJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G17540HT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G17545ER", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G17597KD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G17689DH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G17740GV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G17754FF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G17769YX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G17851MM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G17857ZF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G17909DH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G17940HM", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G17964DY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G17964XN", "type": "N-linked", "subtype": "Core-fucosylated" }, { 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"subtype": "Triantennary" }, { "glytoucan_ac": "G18800AB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G18818DM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G18897BX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G18913QB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G18969PK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G18972WN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G19104OH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G19140RD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G19146BQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G19197RD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G19209QL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G19212IL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G19231UV", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G19243TV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G19289JN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G19294RF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G19304XI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G19429IT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G19469VZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G19471FE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G19541IU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G19565UD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G19607EP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G19636RY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G19664QJ", "type": "O-linked", "subtype": "Core 2" }, { 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{ "glytoucan_ac": "G20326YW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G20394QS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G20453WS", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G20636FS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G20650NV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G20652MD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G20662UG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G20711NK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G20745AF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20758LC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G20768QM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G20794PH", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G20873FQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G20877ZV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G20878US", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G20885BK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G20909AP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G20983SP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G21005TQ", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G21072IJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21219OJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21327MO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G21343HW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21411AR", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G21437MZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G21445UU", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G21454AE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21459ST", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21470TX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21473QQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G21550DG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G21627CA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G21737WY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G21755KD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G21756MV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G21898KP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G21933XG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G22014NH", "type": "N-linked", "subtype": "Tetraantennary" }, { 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"G23511JD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G23546HG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G23598DU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G23616ZX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G23654OQ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G23718VU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G23722TU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G23726CO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G23773CP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G23819TW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G23866EW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G23914JN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G24046UO", "type": "N-linked", "subtype": 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"N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G25104PV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G25127JU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25173WC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G25224QY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G25297CU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G25322NY", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G25322UQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G25392ZR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G25416CE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G25423CA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G25460BQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G25471TG", "type": "N-linked", "subtype": "Tetraantennary" }, { 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"type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G40289VL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40341NV", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G40343KH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G40411HQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G40445LE", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G40452FK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G40463TJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G40472QE", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G40513EI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G40542QP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G40554DX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G40641DI", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G40707SF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G40757HO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G40799GH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G40813TL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G40849ON", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G40865GN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G40903ZD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G40909AN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G41030WJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G41068PD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G41087ZA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G41095QB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G41171HL", "type": "N-linked", "subtype": "Tetraantennary" }, { 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"Complex" }, { "glytoucan_ac": "G41836YE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G41850YN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G41859XD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G41879EJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G41912CL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G41953RN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G41981MA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G42011CP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G42022OY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G42028DN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G42060JY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G42089IU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42123IU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G42133YG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G42139GR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G42305NI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G42365AT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G42380GI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G42393CS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42482KG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G42531AE", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G42600SB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G42635DR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G42650PV", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G42667BL", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G42686NP", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G42686NQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G42713ZO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G42731RJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G42746CP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G42772WO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G42779AL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G42824AQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G42855XG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G42941KJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G43088GK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G43095XB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G43164CL", "type": "N-linked", "subtype": "Triantennary" }, { 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"N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G43556OK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G43596KL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G43645EE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G43665PB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G43668RJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G43680SH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G43702IX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G43749GH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G43832DJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G43873AE", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G43873BV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G43873MM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G43981RC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G43991QD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G44005DK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G44027TT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G44089VB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G44137YR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G44156OE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G44167WJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G44171LY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G44233ST", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G44246AC", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G44324HQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G44346CQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G44361OH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G44374JT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G44451GP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G44515AZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G44568DG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G44575RK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G44617UT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G44618FI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G44639PM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G44639QZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G44688UB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G44722KG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G44723YJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G44759TK", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G44826KU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G44904UE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G44924MQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G45050CR", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G45061BH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G45079TK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G45086UC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G45104SZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G45116MR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G45209NR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G45332NZ", "type": "N-linked", "subtype": "Triantennary" }, { 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"subtype": "Triantennary" }, { "glytoucan_ac": "G46385MK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G46387UV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G46407AA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G46412RZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G46428UN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G46470AD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G46503WU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G46620QA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G46626ZQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G46746UE", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G46754UT", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46767VX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G46785SS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46915JA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G46945LQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G46992PB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G47043LK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G47065QM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G47085IG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G47152AG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G47164CZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G47169TB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G47257MC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G47279LF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G47286YR", "type": "N-linked", "subtype": "Core-fucosylated" }, { 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}, { "glytoucan_ac": "G47763TG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G47816DI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G47822QX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G47828IM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G47835DG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G47845XM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G47913QC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G47961DI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G47973FK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G48029ME", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G48040FY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G48064BJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G48069JX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G48109OV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G48205IY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G48266EY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G48329CR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G48330KH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G48390CO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G48465YI", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G48488XT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G48503ML", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G48518DG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G48714ZW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G48732OI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G48757CJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G48767NV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G48768LA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G48809ZO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G48822BJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G48879CK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G48882DX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G48954CA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G48987LP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G49003MO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G49020UX", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G49053WC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G49062LU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G49084JY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G49101OB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G49225WK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G49235GA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G49305IN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G49322HB", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G49353WO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G49390AT", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G49446SO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G49502SC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G49544FY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G49562JB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G49588KJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G49616WZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G49721KD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G49777JB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G49832FF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G49844LC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G49935CA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G50068PO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G50135PA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G50189HQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G50211SY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G50252SB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50364FV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G50387OH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G50427EN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G50462VS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G50489VC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G50508SG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G50518XT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G50525GP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G50554LM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G50584UT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G50652EJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50660UT", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G50706US", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G50731QB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G50782LR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G50802FP", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G50808YS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50821RC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G50880EE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G50896EJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50915WK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G50937OW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G50997KD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G51018GI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G51066TO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G51074KT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G51086FE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G51098AA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G51162XR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G51168MK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G51229TU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G51324UL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G51333KM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G51402XK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G51411MW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G51500KY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51530ER", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G51586EE", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G51678TA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G51710QD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G51768ZH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G51793MY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G51878LH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G51891DI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G51921XC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G51929IB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G52021KR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G52120NK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52210EC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G52266YB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G52345FK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G52383QH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G52441NC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G52483OL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G52497YI", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G52593LK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G52621OJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G52645LW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G52676LZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G52701UC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G52790YS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G52794ID", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G52892AY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G52971DE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G53028BV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53064IK", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G53173PI", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G53208AY", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G53220ZS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53234IR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G53361RA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53396PX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53396TS", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G53472RQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53504BR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G53527TY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53574BW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53723XK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53752TA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53768QW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G53778MF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53795OV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G53800IE", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G53800MQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G53809CJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53812BX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53818ZZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53840IC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53856PB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53869ZZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G53923UR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53944MR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53962WT", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G53993HS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G54010TZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G54018RP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G54076UX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G54083SI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54158IT", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G54162HE", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G54198RS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G54300AX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G54317NJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G54338PJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G54380FJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G54413TX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G54505OS", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G54507ZF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G54513OG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G54555CN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G54556LG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G54575IS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G54590FS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G54599TH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G54634UE", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G54716GM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G54741SP", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G54956ME", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G54970OI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G55015QS", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G55020XV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G55043JL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55144QZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G55146EO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G55157XP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G55251MD", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G55302QK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G55360MM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G55414RN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G55481KF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G55508HJ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G55630OZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G55638XL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55645TD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G55719AB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G55803NG", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G55818EE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G55827GK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G55867TY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G55890VR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G55959FD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G56095ZZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G56147VV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G56163DR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G56186MJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56246PC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G56293JI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G56318NV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G56354PO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G56408DR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G56418NV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G56485SI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G56492JP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G56499YQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G56516KW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G56529CD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G56546LQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G56549DH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G56577TY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G56586OT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G56616DG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G56657CK", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G56691CA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G56696EG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G56703XH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G56770AH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G56809FB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G56830SM", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G56837YQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G56840FF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G56850HF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G56862WE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G56891ZN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G56963QZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G56988MG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G57007KH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G57075OH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G57117TO", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G57125VL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G57130XG", "type": "O-linked", "subtype": "Core 4" }, { 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"N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G65156KN", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G65226QM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G65243FP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G65262KR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65302CF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G65305LF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G65327EP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G65363PV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G65408JY", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G65419YA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G65449BO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G65617KZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G65619MS", 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Classification" ] }, { "id": "PTHR45625", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45625", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45625:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45625:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00160", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00160", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001014869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014869", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16237", "url": "https://www.rhea-db.org/rhea/16237", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LW66", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LW66-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW66-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3V7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3V7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3V7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3V7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E992", "url": "https://www.uniprot.org/uniprotkb/Q5E992", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E992-1", "url": "https://www.uniprot.org/uniprotkb/Q5E992-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAIPPDSWQPPNVYLETSMGIIVLELYWKHAPKTCKNFAELARRGYYNGTKFHRIIKDFMIQGGDPTGTGRGGASIYGKQFEDELHPDLKFTGAGILAMANAGPDTNGSQFFVTLAPTQWLDGKHTIFGRVCQGIGMVNRVGMVETNSQDRPVDDVKIIKAYPSG", "length": 166, "header": "sp|Q5E992-1|PPIL1_BOVIN Isoform 1 of Peptidyl-prolyl cis-trans isomerase-like 1 OS=Bos taurus OX=9913 GN=PPIL1 PE=2 SV=1 CANONICAL=Q5E992-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LW66-1", "url": "https://www.uniprot.org/uniprotkb/Q5E992/entry#A0A3Q1LW66-1", "sequence": { "sequence": "MAAIPPDSWQPPNVYLETSMGIIVLELYWKHAPKTCKNFAELARRGYYNGTKFHRIIKDFMIQGGDPTGTGTVKSVIYQGLGAGILAMANAGPDTNGSQFFVTLAPTQWLDGKHTIFGRVCQGIGMVNRVGMVETNSQDRPVDDVKIIKAYPSG", "length": 154, "header": "tr|A0A3Q1LW66-1|PPIL1_BOVIN Computationally mapped isoform of Peptidyl-prolyl cis-trans isomerase-like 1 OS=Bos taurus OX=9913 GN=PPIL1 PE=2 SV=1 CANONICAL=Q5E992-1" }, "locus": { "chromosome": "23", "start_pos": 10791496, "end_pos": 10772160, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068174.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068174.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059626.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059626.1" } ] } }, { "isoform_ac": "A0AAA9T3V7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E992/entry#A0AAA9T3V7-1", "sequence": { "sequence": "PHALDSRPWRCGWGWGSFLCLVSNPPNFGISRVERREPEAGCSSRGSRRIDAGSSDRLRSFPPASPWRRFLQTLGSRPTCTWRPGRGGASIYGKQFEDELHPDLKFTGAGILAMANAGPDTNGSQFFVTLAPTQWLDGKHTIFGRVCQGIGMVNRVGMVETNSQDRPVDDVKIIKAYPSG", "length": 180, "header": "tr|A0AAA9T3V7-1|PPIL1_BOVIN Computationally mapped isoform of Peptidyl-prolyl cis-trans isomerase-like 1 OS=Bos taurus OX=9913 GN=PPIL1 PE=2 SV=1 CANONICAL=Q5E992-1" }, "locus": { "chromosome": "23", "start_pos": 10791693, "end_pos": 10772160, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099061.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099061.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092465.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092465.1" } ] } }, { "isoform_ac": "Q5E992-1", "url": "https://www.uniprot.org/uniprotkb/Q5E992/entry#Q5E992-1", "sequence": { "sequence": "MAAIPPDSWQPPNVYLETSMGIIVLELYWKHAPKTCKNFAELARRGYYNGTKFHRIIKDFMIQGGDPTGTGRGGASIYGKQFEDELHPDLKFTGAGILAMANAGPDTNGSQFFVTLAPTQWLDGKHTIFGRVCQGIGMVNRVGMVETNSQDRPVDDVKIIKAYPSG", "length": 166, "header": "sp|Q5E992-1|PPIL1_BOVIN Isoform 1 of Peptidyl-prolyl cis-trans isomerase-like 1 OS=Bos taurus OX=9913 GN=PPIL1 PE=2 SV=1 CANONICAL=Q5E992-1" }, "locus": { "chromosome": "23", "start_pos": 10791496, "end_pos": 10772160, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003071.3", "url": "https://www.ensembl.org/id/ENSBTAT00000003071.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003071.1", "url": "https://www.ensembl.org/id/ENSBTAP00000003071.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 149, "end_pos": 149, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E992", "url": "https://www.uniprot.org/uniprotkb/Q5E992" } ], "site_lbl": "Ser149" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E992", "url": "https://www.uniprot.org/uniprotkb/Q5E992" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:508179", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508179", "resource": "KEGG Pathway" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PW44-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase", "gene_name": "PPIL1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAVPPDSWQPPTVSMETTMGTLVLELYWRHAPRTCKNFAELCRRGYYNGTRFHRVIRDFMVQGGDPTGTGRGGASIYGKHFEDELHSELKFTGAGILAMANAGPDTNGSQFFITLAPAQWLDGKHTIFGRVCQGIGVLGRVGMVETNAQDRPLDDVKVLKAVPAG", "length": 166 }, "evidence": [ { "id": "Q5E992", "url": "https://omabrowser.org/oma/group/Q5E992/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A4X1STN7-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase", "gene_name": "PPIL1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAIPPDSWQPPNVYLETSMGIIVLELYWKHAPKTCKNFAELARRGYYNGTKFHRIIKDFMIQGGDPTGTGRGGASIYGKQFEDELHPDLKFTGAGILAMANAGPDTNGSQFFVTLAPTQWLDGKHTIFGRVCQGIGMVNRVGMVETNSQDRPVDDVKIIKAYPSG", "length": 166 }, "evidence": [ { "id": "Q5E992", "url": "https://omabrowser.org/oma/group/Q5E992/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HKD0-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase", "gene_name": "Ppil1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAIPPDTWQPPNVYLETSMGIIVLELYWKHAPKTCKNFAELARRGYYNGTKFHRIIKDFMIQGGDPTGTGRGGASIYGKQFEDELHPDLKFTGAGILAMANAGPDTNGSQFFVTLAPTQWLDGKHTIFGRVCQGIGMVNRVGMVETNSQDRPVDDVKILKAYPSG", "length": 166 }, "evidence": [ { "id": "Q5E992", "url": "https://omabrowser.org/oma/group/Q5E992/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9D0W5-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase-like 1", "gene_name": "Ppil1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAIPPDTWQPPNVYLETSMGVIVLELYWKHAPKTCKNFAELARRGYYNGTKFHRIIKDFMIQGGDPTGTGRGGASIYGKQFEDELHPDLKFTGAGILAMANAGPDTNGSQFFVTLAPTQWLDGKHTIFGRVCQGIGMVNRVGMVETNSQDRPVDDVKILKAYPSG", "length": 166 }, "evidence": [ { "id": "Q5E992", "url": "https://omabrowser.org/oma/group/Q5E992/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NI62-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase cypE", "gene_name": "cypE", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTEQTVTLQTTVGDITLELYYNHAPKACKNFYELSKRGYYDNTIFHRLIKDFMIQGGDPLGNGRGGESIYGKKFEDEITKELKHTGAGILSMANSGVNSNGSQFFITFGPTPWLDGKHTIFGRVKSGMKVVQKMNAMQTNNDKPIDEIRIIKATAN", "length": 156 }, "evidence": [ { "id": "Q5E992", "url": "https://omabrowser.org/oma/group/Q5E992/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9SIH1-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase CYP18-2", "gene_name": "CYP18-2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSARPEGSPPEVTLETSMGPFTVEMYYKHSPRTCRNFLELSRRGYYDNVLFHRIVKDFIVQGGDPTGTGRGGESIYGSKFEDEINKELKHTGAGILSMANAGPNTNGSQFFITLAPQPSLDGKHTIFGRVCRGMEVIKRLGSVQTDNTDRPIHEVKILRTKVID", "length": 164 }, "evidence": [ { "id": "Q5E992", "url": "https://omabrowser.org/oma/group/Q5E992/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9W0Q2-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase", "gene_name": "Cypl", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLSLSDPNNAGGIPDKAWQPHFVTLETSMGEITVELYWKHAPNTCRNFAELSRRGYYNNVVFHRIIRDFMIQGGDPTGTGRGGASIYGSEFADELHGDLRHTGAGILSMANSGPDTNGSQFFITLAPTQWLDGKHTIFGRVYTGMEVVKRIGMVETDKNDRPVDPLRIIKAKVEKL", "length": 176 }, "evidence": [ { "id": "Q5E992", "url": "https://omabrowser.org/oma/group/Q5E992/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y3C6-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase-like 1", "gene_name": "PPIL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAIPPDSWQPPNVYLETSMGIIVLELYWKHAPKTCKNFAELARRGYYNGTKFHRIIKDFMIQGGDPTGTGRGGASIYGKQFEDELHPDLKFTGAGILAMANAGPDTNGSQFFVTLAPTQWLDGKHTIFGRVCQGIGMVNRVGMVETNSQDRPVDDVKIIKAYPSG", "length": 166 }, "evidence": [ { "id": "Q5E992", "url": "https://omabrowser.org/oma/group/Q5E992/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E992", "url": "https://www.uniprot.org/uniprotkb/Q5E992" } ], "pmid": "" }, { "name": "catalytic step 2 spliceosome", "id": "GO:0071013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071013", "evidence": [ { "database": "UniProtKB", "id": "Q5E992", "url": "https://www.uniprot.org/uniprotkb/Q5E992" } ], "pmid": "" }, { "name": "U2-type catalytic step 2 spliceosome", "id": "GO:0071007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071007", "evidence": [ { "database": "UniProtKB", "id": "Q5E992", "url": "https://www.uniprot.org/uniprotkb/Q5E992" } ], "pmid": "" }, { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "Q5E992", "url": "https://www.uniprot.org/uniprotkb/Q5E992" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "Q5E992", "url": "https://www.uniprot.org/uniprotkb/Q5E992" } ], "pmid": "" }, { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "Q5E992", "url": "https://www.uniprot.org/uniprotkb/Q5E992" } ], "pmid": "" }, { "name": "embryonic brain development", "id": "GO:1990403", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990403", "evidence": [ { "database": "UniProtKB", "id": "Q5E992", "url": "https://www.uniprot.org/uniprotkb/Q5E992" } ], "pmid": "" }, { "name": "protein peptidyl-prolyl isomerization", "id": "GO:0000413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000413", "evidence": [ { "database": "UniProtKB", "id": "Q5E992", "url": "https://www.uniprot.org/uniprotkb/Q5E992" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "peptidyl-prolyl cis-trans isomerase activity", "id": "GO:0003755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003755", "evidence": [ { "database": "UniProtKB", "id": "Q5E992", "url": "https://www.uniprot.org/uniprotkb/Q5E992" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16237", "name": "", "equation": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M4A4-1", "P18203-1", "Q5BIN5-1", "A6QPY8-1", "F1N4S5-1", "F1N6W2-1", "G3X8B1-1", "A0A3Q1LI03-1", "A0AAA9TG77-1", "F1MNW5-1", "E1B9G4-1", "G3MXV0-1", "Q2KJC8-1", "A0AAF6YJC8-1", "A0AAF6YJR2-1", "P26882-1", "F6RD06-1", "Q32PA9-1", "Q0P5D0-1", "Q2KJ44-1", "Q2HJ89-1", "Q08E11-1", "Q9TRY0-1", "A0A3Q1LK42-1", "A4FV72-1", "P26884-1", "P30404-1", "P62935-1", "P68107-1", "Q29RZ2-1", "P80311-1", "A0AAA9RV00-1", "F1MU79-1", "A0A3Q1LJJ1-1", "Q5E992-1", "Q2YDL5-1", "A0AAA9U018-1", "A0ABI0NKM5-1", "A0ABI0NMT7-1", "A0A3Q1LSB7-1" ], "evidence": [ { "id": "16237", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16237" } ] }, { "id": "R-BTA-9770141", "name": "Formation of the Spliceosomal C* complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-5688092", "R-BTA-5688093", "R-BTA-72073", "R-BTA-9769591", "R-BTA-9769593", "R-BTA-9769594", "R-BTA-9769596", "R-BTA-9769598", "R-BTA-9769599", "R-BTA-9769601" ], "output_participant_list": [ "R-BTA-72060", "R-BTA-8867898", "R-BTA-9770419", "R-BTA-9770425", "R-BTA-9770427", "R-BTA-9770428", "R-BTA-9770430" ], "enzyme_list": [ "P19120-1", "A5PJW8-1", "G3MZY8-1", "Q17R09-1", "Q29RZ2-1", "A0AAA9RV00-1", "Q08E38-1", "Q2NL22-1", "E1BH78-1", "F1MEM4-1", "F1N6W2-1", "A0A3Q1MR43-1", "A0A3Q1M155-1", "Q3T147-1", "Q5E992-1", "E1B9G4-1", "E1BDN4-1" ], "evidence": [ { "id": "R-BTA-9770141", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770141" } ] }, { "id": "R-BTA-9770145", "name": "Formation of the Spliceosomal Bact complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-8849149", "R-BTA-8850837", "R-BTA-8850839", "R-BTA-8865956", "R-BTA-8867885", "R-BTA-8867892", "R-BTA-8952110", "R-BTA-9769561", "R-BTA-9769562", "R-BTA-9769563" ], "output_participant_list": [ "R-BTA-3246027", "R-BTA-53517", "R-BTA-71875", "R-BTA-71881", "R-BTA-8867887", "R-BTA-8867889", "R-BTA-8867895", "R-BTA-8867897", "R-BTA-9770239", "R-BTA-9770248", "R-BTA-9770255", "R-BTA-9770259" ], "enzyme_list": [ "P19120-1", "A5PJW8-1", "G3MZY8-1", "Q0P5D0-1", "A0AAA9RV00-1", "Q08E38-1", "Q28141-1", "Q2NL22-1", "E1BF68-1", "E1BH78-1", "A0A3Q1MR43-1", "A0A3Q1M155-1", "Q3T147-1", "Q5E992-1", "E1B9G4-1" ], "evidence": [ { "id": "R-BTA-9770145", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770145" } ] }, { "id": "R-BTA-9770236", "name": "Formation of the Spliceosomal P complex and exon ligation", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-9769588", "R-BTA-9769590", "R-BTA-9769602" ], "output_participant_list": [ "R-BTA-6791189", "R-BTA-8849139", "R-BTA-8952113" ], "enzyme_list": [ "P19120-1", "A5PJW8-1", "G3MZY8-1", "Q29RZ2-1", "A0AAA9RV00-1", "Q08E38-1", "Q2NL22-1", "E1BH78-1", "F1MEM4-1", "F1N6W2-1", "A0A3Q1MR43-1", "A0A3Q1M155-1", "Q3T147-1", "Q5E992-1", "E1B9G4-1" ], "evidence": [ { "id": "R-BTA-9770236", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770236" } ] }, { "id": "R-BTA-9770847", "name": "Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-5688097", "R-BTA-8869310", "R-BTA-8869311", "R-BTA-9770846" ], "output_participant_list": [ "R-BTA-6814858", "R-BTA-8865888", "R-BTA-8867893", "R-BTA-9769592" ], "enzyme_list": [ "P19120-1", "A5PJW8-1", "G3MZY8-1", "Q29RZ2-1", "A0AAA9RV00-1", "Q08E38-1", "Q2NL22-1", "E1BH78-1", "F1MEM4-1", "A0A3Q1MR43-1", "A0A3Q1M155-1", "Q5E992-1", "E1B9G4-1" ], "evidence": [ { "id": "R-BTA-9770847", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770847" } ] }, { "id": "R-BTA-9794542", "name": "Formation of the Spliceosomal C complex containing intron lariat", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P19120-1", "A5PJW8-1", "G3MZY8-1", "Q17R09-1", "Q29RZ2-1", "A0AAA9RV00-1", "Q08E38-1", "Q2NL22-1", "E1BH78-1", "F1N6W2-1", "A0A3Q1MR43-1", "A0A3Q1M155-1", "Q3T147-1", "Q5E992-1", "E1B9G4-1", "E1BDN4-1" ], "evidence": [ { "id": "R-BTA-9794542", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9794542" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-3246027", "participant_name": "TCERG1 [nucleoplasm]", "crossref": [ { "id": "ENSBTAT00000067382", "database": "ENSEMBL", "url": "" }, { "id": "35685", "database": "VGNC", "url": "" }, { "id": "ENSBTAG00000003259", "database": "ENSEMBL", "url": "" }, { "id": "A0A3Q1NC33", "database": "UniProt", "url": "" }, { "id": "XP_005209676.2", "database": "RefSeq", "url": "" }, { "id": "ENSBTAP00000068923", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-53517", "participant_name": "DHX9 [nucleoplasm]", "crossref": [ { "id": "NP_776461.1", "database": "RefSeq", "url": "" }, { "id": "Q28141", "database": "UniProt", "url": "" }, { "id": "28060", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-5688092", "participant_name": "DHX8 [nucleoplasm]", "crossref": [ { "id": "F1MEM4", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000008339", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000010976", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000010976", "database": "ENSEMBL", "url": "" }, { "id": "NP_001193020.2", "database": "RefSeq", "url": "" }, { "id": "28059", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-5688093", "participant_name": "PRPF18 [nucleoplasm]", "crossref": [ { "id": "Q2HJ41", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000017244", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000022912", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000022912", "database": "ENSEMBL", "url": "" }, { "id": "NP_001068791.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-BTA-5688097", "participant_name": "DHX15 [nucleoplasm]", "crossref": [ { "id": "A5D7D9", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000008896", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000011714", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000011714", "database": "ENSEMBL", "url": "" }, { "id": "NP_001091487.1", "database": "RefSeq", "url": "" }, { "id": "28048", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-6791189", "participant_name": "MTREX [nucleoplasm]", "crossref": [ { "id": "34649", "database": "VGNC", "url": "" }, { "id": "A6H714", "database": "UniProt", "url": "" } ] }, { "participant_id": "R-BTA-6814858", "participant_name": "SRRT [nucleoplasm]", "crossref": [ { "id": "NP_001077177.1", "database": "RefSeq", "url": "" }, { "id": "A4IFB1", "database": "UniProt", "url": "" }, { "id": "35296", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-71875", "participant_name": "TXNL4A [nucleoplasm]", "crossref": [ { "id": "F1MTU6", "database": "UniProt", "url": "" }, { "id": "36543", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-71881", "participant_name": "PRPF6 [nucleoplasm]", "crossref": [ { "id": "NP_001039840.1", "database": "RefSeq", "url": "" }, { "id": "Q2KJJ0", "database": "UniProt", "url": "" }, { "id": "33382", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-72060", "participant_name": "DHX38 [nucleoplasm]", "crossref": [ { "id": "57044", "database": "VGNC", "url": "" }, { "id": "ENSBTAP00000042866", "database": "ENSEMBL", "url": "" }, { "id": "3.6.4.13", "database": "IntEnz", "url": "" }, { "id": "Q17R09", "database": "UniProt", "url": "" }, { "id": "ENSBTAT00000045480", "database": "ENSEMBL", "url": "" }, { "id": "NP_001069266.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAG00000013265", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-72073", "participant_name": "SLU7 [nucleoplasm]", "crossref": [ { "id": "Q3ZBE5", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000008457", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000011131", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000011131", "database": "ENSEMBL", "url": "" }, { "id": "NP_001160089.1", "database": "RefSeq", "url": "" }, { "id": "34971", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-8849139", "participant_name": "DDX39B [nucleoplasm]", "crossref": [ { "id": "NP_001028801.1", "database": "RefSeq", "url": "" }, { "id": "Q3T147", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000029090", "database": "ENSEMBL", "url": "" }, { "id": "27965", "database": "VGNC", "url": "" }, { "id": "ENSBTAG00000014490", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000029090", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-8849149", "participant_name": "EIF4A3 [nucleoplasm]", "crossref": [ { "id": "Q2NL22", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000016023", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000021327", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000021327", "database": "ENSEMBL", "url": "" }, { "id": "NP_001039653.1", "database": "RefSeq", "url": "" }, { "id": "28406", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-8850837", "participant_name": "DHX16 [nucleoplasm]", "crossref": [ { "id": "E1BF68", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000006960", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000009148", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000009148", "database": "ENSEMBL", "url": "" }, { "id": "NP_001193139.1", "database": "RefSeq", "url": "" }, { "id": "28049", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-8850839", "participant_name": "GPKOW [nucleoplasm]", "crossref": [ { "id": "E1BN14", "database": "UniProt", "url": "" }, { "id": "29535", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-8865888", "participant_name": "SRRM2 [nucleoplasm]", "crossref": [ { "id": "ENSBTAT00000071602", "database": "ENSEMBL", "url": "" }, { "id": "58613", "database": "VGNC", "url": "" }, { "id": "ENSBTAG00000012683", "database": "ENSEMBL", "url": "" }, { "id": "A0A3Q1M0D6", "database": "UniProt", "url": "" }, { "id": "XP_002697976.2", "database": "RefSeq", "url": "" }, { "id": "ENSBTAP00000066669", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-8865956", "participant_name": "CWC22 [nucleoplasm]", "crossref": [ { "id": "F1MWG3", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000021726", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000028962", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000028962", "database": "ENSEMBL", "url": "" }, { "id": "XP_005202345.1", "database": "RefSeq", "url": "" }, { 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZC25-1", "uniprot_ac": "Q3ZC25", "uniprot_id": "T106B_BOVIN", "mass": { "chemical_mass": 31213.0, "monoisotopic_mass": 31213.0 }, "refseq": { "ac": "NP_001029509", "name": "transmembrane protein 106B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029509" }, "gene_names": [ { "name": "TMEM106B", "type": "recommended", "evidence": [ { "id": "Q3ZC25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25" } ] }, { "name": "TMEM106B", "type": "synonym", "evidence": [ { "id": "NP_001029509", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029509" } ] } ], "protein_names": [ { "name": "Transmembrane protein 106B", "type": "recommended", "evidence": [ { "id": "Q3ZC25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 106B", "type": "synonym", "evidence": [ { "id": "NP_001029509", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029509" } ] } ], "function": [ { "annotation": "In neurons, involved in the transport of late endosomes/lysosomes (By similarity). May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (By similarity). May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (By similarity). In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (By similarity). It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is particularly important in the sorting of lysosomes in axons or in dendrites (By similarity). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (By similarity). Required for proper lysosomal acidification (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC25", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25#function" }, { "database": "UniProtKB", "id": "Q9NUM4", "url": "https://www.uniprot.org/uniprotkb/Q9NUM4#function" }, { "database": "UniProtKB", "id": "Q6AYA5", "url": "https://www.uniprot.org/uniprotkb/Q6AYA5#function" }, { "database": "UniProtKB", "id": "Q80X71", "url": "https://www.uniprot.org/uniprotkb/Q80X71#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZC25", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM106B", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25", "locus": { "chromosome": "4", "start_pos": 20410484, "end_pos": 20366146, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019750", "url": "https://www.ensembl.org/id/ENSBTAG00000019750" } ] } } ], "crossref": [ { "id": "Q3ZC25", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZC25", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019750", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019750", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508903", "url": "https://www.ncbi.nlm.nih.gov/gene/508903", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048509", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048509", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048511", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048511", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508903", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508903", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FGHSEQT", "url": "https://omabrowser.org/oma/group/FGHSEQT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LZT5", "url": "https://www.orthodb.org/?gene=A0A3Q1LZT5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZC25", "url": "https://www.orthodb.org/?gene=Q3ZC25", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28556", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28556", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28556:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28556:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07092", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07092", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21002", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21002", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029509", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZT5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZT5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZT5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVP4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S378", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S378", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S378-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S378-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC25", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC25-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKSFSHLPLHSNKEDGYDGMTSTENIRNGLVNGEVHNEDGRSGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDVQKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITSIGPLDMKQIDYTVPTVIAEEMSYMFDFCTLLTIKVHNIVLMMQVTVTTTYFGHSEQISQERYQYVDCGRNTTYHLGQSEYLNVLQPQQ", "length": 275, "header": "sp|Q3ZC25-1|T106B_BOVIN Isoform 1 of Transmembrane protein 106B OS=Bos taurus OX=9913 GN=TMEM106B PE=2 SV=1 CANONICAL=Q3ZC25-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZT5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25/entry#A0A3Q1LZT5-1", "sequence": { "sequence": "MGKSFSHLPLHSNKEDGYDGMTSTENIRNGLVNGEVHNEDGRSGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDVQKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITSIGPLDMKQIDYTVPTVIAEEMMLLSIYFIFRVTVTTTYFGHSEQISQERYQYVDCGRNTTYHLGQSEYLNVLQPQQ", "length": 263, "header": "tr|A0A3Q1LZT5-1|T106B_BOVIN Computationally mapped isoform of Transmembrane protein 106B OS=Bos taurus OX=9913 GN=TMEM106B PE=2 SV=1 CANONICAL=Q3ZC25-1" }, "locus": { "chromosome": "4", "start_pos": 20387789, "end_pos": 20368658, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081462.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081462.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063168.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063168.1" } ] } }, { "isoform_ac": "A0AAA9RVP4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25/entry#A0AAA9RVP4-1", "sequence": { "sequence": "MGKSFSHLPLHSNKEDGYDGMTSTENIRNGLVNGEVHNEDGRSGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDVQKRTIYLNITIDYTVPTVIAEEMSYMFDFCTLLTIKVHNIVLMMQVTVTTTYFGHSEQISQERYQYVDCGRNTTYHLGQSEYLNVLQPQQ", "length": 228, "header": "tr|A0AAA9RVP4-1|T106B_BOVIN Computationally mapped isoform of Transmembrane protein 106B OS=Bos taurus OX=9913 GN=TMEM106B PE=2 SV=1 CANONICAL=Q3ZC25-1" }, "locus": { "chromosome": "4", "start_pos": 20387789, "end_pos": 20368658, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091126.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091126.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075044.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075044.1" } ] } }, { "isoform_ac": "A0AAA9S378-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25/entry#A0AAA9S378-1", "sequence": { "sequence": "MGKSFSHLPLHSNKEDGYDGMTSTENIRNGLVNGEVHNEDGRSGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDVQKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITSIGPLDMKQIDYTVPTVIAEEMSYMFDFCTLLTIKVHNIVLMMQVTVTTTYFGHSEQISQESAGEDSRESLGLQGDQTNQP", "length": 267, "header": "tr|A0AAA9S378-1|T106B_BOVIN Computationally mapped isoform of Transmembrane protein 106B OS=Bos taurus OX=9913 GN=TMEM106B PE=2 SV=1 CANONICAL=Q3ZC25-1" }, "locus": { "chromosome": "4", "start_pos": 20410466, "end_pos": 20368658, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100414.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100414.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079558.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079558.1" } ] } }, { "isoform_ac": "Q3ZC25-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25/entry#Q3ZC25-1", "sequence": { "sequence": "MGKSFSHLPLHSNKEDGYDGMTSTENIRNGLVNGEVHNEDGRSGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDVQKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITSIGPLDMKQIDYTVPTVIAEEMSYMFDFCTLLTIKVHNIVLMMQVTVTTTYFGHSEQISQERYQYVDCGRNTTYHLGQSEYLNVLQPQQ", "length": 275, "header": "sp|Q3ZC25-1|T106B_BOVIN Isoform 1 of Transmembrane protein 106B OS=Bos taurus OX=9913 GN=TMEM106B PE=2 SV=1 CANONICAL=Q3ZC25-1" }, "locus": { "chromosome": "4", "start_pos": 20387789, "end_pos": 20368658, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026319.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026319.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026319.4", "url": "https://www.ensembl.org/id/ENSBTAP00000026319.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 146, "start_aa": "Asn", "end_pos": 146, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn146", "evidence": [ { "id": "Q3ZC25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 152, "start_aa": "Asn", "end_pos": 152, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn152", "evidence": [ { "id": "Q3ZC25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 165, "start_aa": "Asn", "end_pos": 165, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn165", "evidence": [ { "id": "Q3ZC25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "Q3ZC25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 257, "start_aa": "Asn", "end_pos": 257, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn257", "evidence": [ { "id": "Q3ZC25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:508903", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508903", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PUI5-1", "protein_name": "Transmembrane protein 106B", "gene_name": "TMEM106B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKKMGKSLSHLPIHTCKEDGYDGGTVSDNMRNGLVHSESHGEDGRCGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVTASVIVCLLLSGLAVFFLFPRSVDVEYIGVKSVYVNYEQSRRIIYLNITNTLNITNNNYYSVEVANITAQVQFSKTVIGKARLNNITNIGPLDMKQIDYMVPTVIQDEMSYMFDFCTLASIKVHNIVVMMQVTVTTSYFGHSEQISREKYQYVDCGGNTTYQLGQSEYLNVLQPPQ", "length": 278 }, "evidence": [ { "id": "Q3ZC25", "url": "https://omabrowser.org/oma/group/Q3ZC25/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A4X1TN99-1", "protein_name": "Transmembrane protein 106B", "gene_name": "TMEM106B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGKSFSHLPLHSNKEDAYDAVTSTENMRNGLVNSEVHNEDGRNGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDVQKRTIYLNITNTLNITNNNYYSVEVENIIAQVQFSKTVIGKARLNNITKIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLISIKVHNIVLMMQVTVTTTYFGHSEQISQERYQYVDCGRNTTYQLGQSEYLNVLQPQQ", "length": 275 }, "evidence": [ { "id": "Q3ZC25", "url": "https://omabrowser.org/oma/group/Q3ZC25/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GW36-1", "protein_name": "Transmembrane protein 106B", "gene_name": "Tmem106b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGKSLSHLPLHSNKEDGYDGVTSTDSMRNGLVNSEVHNEDGRNGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVSVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDFQKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITNIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLISIKVHNIVLMMQVTVTTTYFGHSEQISQERYQYVDCGRNTTYQLAQSEYLNVLQPQQ", "length": 275 }, "evidence": [ { "id": "Q3ZC25", "url": "https://omabrowser.org/oma/group/Q3ZC25/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q1LWC2-1", "protein_name": "Transmembrane protein 106B", "gene_name": "tmem106b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGKALSHVAKHTCHDECQDSLTSSPGYSAMQTDDSKSGGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVILCLLLCTLAVFFLFPRSIDVNYVGVKSVYVSYDQSKRIVYLNVTNSLNITNNNYYSVDVANITARVQFSQTVIGKTRISNITTIGPLDMKQIDYMVPTTIADEMSYMYDYCTLQSIKVHNIVVMMQITVTTVYFGHAEQVSQEMYQYVDCGGNTTALHEYSLNTPLTG", "length": 267 }, "evidence": [ { "id": "Q3ZC25", "url": "https://omabrowser.org/oma/group/Q3ZC25/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6AYA5-1", "protein_name": "Transmembrane protein 106B", "gene_name": "Tmem106b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGKSLSHLPLHSNKEDGYDGVTSTDNMRNGLVSSEVRNEDGRSGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDSQKRMIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLSNITNIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLPSIKVHNIVLMMQVTVTTAYFGHSEQISQERYQYVDCGRNTTYQLAQSEYLNVLQPQQ", "length": 275 }, "evidence": [ { "id": "Q3ZC25", "url": "https://omabrowser.org/oma/group/Q3ZC25/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80X71-1", "protein_name": "Transmembrane protein 106B", "gene_name": "Tmem106b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGKSLSHLPLHSNKEDGYDGVTSTDNMRNGLVSSEVHNEDGRNGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIEVKYIGVKSAYVSYDAEKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITNIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLLSIKVHNIVLMMQVTVTTAYFGHSEQISQERYQYVDCGRNTTYQLAQSEYLNVLQPQQ", "length": 275 }, "evidence": [ { "id": "Q3ZC25", "url": "https://omabrowser.org/oma/group/Q3ZC25/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NUM4-1", "protein_name": "Transmembrane protein 106B", "gene_name": "TMEM106B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGKSLSHLPLHSSKEDAYDGVTSENMRNGLVNSEVHNEDGRNGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDVQKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITIIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLISIKVHNIVLMMQVTVTTTYFGHSEQISQERYQYVDCGRNTTYQLGQSEYLNVLQPQQ", "length": 274 }, "evidence": [ { "id": "Q3ZC25", "url": "https://omabrowser.org/oma/group/Q3ZC25/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC25", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC25", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC25", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC25", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ATPase binding", "id": "GO:0051117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051117", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC25", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "lysosome organization", "id": "GO:0007040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007040", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC25", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25" } ], "pmid": "" }, { "name": "dendrite morphogenesis", "id": "GO:0048813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048813", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC25", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25" } ], "pmid": "" }, { "name": "lysosomal transport", "id": "GO:0007041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007041", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC25", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25" } ], "pmid": "" }, { "name": "lysosome localization", "id": "GO:0032418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032418", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC25", "url": "https://www.uniprot.org/uniprotkb/Q3ZC25" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZC25-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 275, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZC25-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZC25" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 146, 152, 165, 184, 257 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 146, "end_pos": 148 }, { "start_pos": 152, "end_pos": 154 }, { "start_pos": 165, "end_pos": 167 }, { "start_pos": 184, "end_pos": 186 }, { "start_pos": 257, "end_pos": 259 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 5 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_n_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", 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"categories": [ "Protein Classification" ] }, { "id": "Q58DG6", "url": "https://www.orthodb.org/?gene=Q58DG6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13318", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13318", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13318:SF44", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13318:SF44", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13318:SF47", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13318:SF47", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13382", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13382", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13382:SF62", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13382:SF62", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25372", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25372", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001421944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421944", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2Q0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2Q0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2Q0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2Q0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MUW9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MUW9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUW9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUW4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUW4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUW4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDE2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SES6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SES6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SES6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SES6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4K0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4K0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4K0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4K0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5P0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5P0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5P0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5P0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DG6", "url": "https://www.uniprot.org/uniprotkb/Q58DG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DG6-1", "url": "https://www.uniprot.org/uniprotkb/Q58DG6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DG6-2", "url": "https://www.uniprot.org/uniprotkb/Q58DG6-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRDVNGVTKSRFEMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL", "length": 436, "header": "sp|Q58DG6-1|FXL20_BOVIN Isoform 1 of F-box/LRR-repeat protein 20 OS=Bos taurus OX=9913 GN=FBXL20 PE=2 SV=2 CANONICAL=Q58DG6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M2Q0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DG6/entry#A0A3Q1M2Q0-1", "sequence": { "sequence": "RCSVNVHCMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL", "length": 430, "header": "tr|A0A3Q1M2Q0-1|FXL20_BOVIN Computationally mapped isoform of F-box/LRR-repeat protein 20 OS=Bos taurus OX=9913 GN=FBXL20 PE=2 SV=2 CANONICAL=Q58DG6-1" }, "locus": { "chromosome": "19", "start_pos": 39788421, "end_pos": 39744098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067357.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067357.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064090.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064090.2" } ] } }, { "isoform_ac": "A0A3Q1MUW9-1", "url": "https://www.uniprot.org/uniprotkb/Q58DG6/entry#A0A3Q1MUW9-1", "sequence": { "sequence": "MPGRLCPMRSGVAGRWGVFLFWVEVEAEKREELATSSRRHHSGRRRRPCWSLEVSPPRRRPHPAGPLPRLGTGTPGPARGPQSLHAAAPGPGRTRRPHEEGRERSDQEQMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL", "length": 531, "header": "tr|A0A3Q1MUW9-1|FXL20_BOVIN Computationally mapped isoform of F-box/LRR-repeat protein 20 OS=Bos taurus OX=9913 GN=FBXL20 PE=2 SV=2 CANONICAL=Q58DG6-1" }, "locus": { "chromosome": "19", "start_pos": 39841993, "end_pos": 39744098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078290.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078290.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058681.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058681.2" } ] } }, { "isoform_ac": "A0AAA9RUW4-1", "url": "https://www.uniprot.org/uniprotkb/Q58DG6/entry#A0AAA9RUW4-1", "sequence": { "sequence": "MMLRLKLQYFGHLMRRVDSLEKTLMLEGTGGRRRRGRQRMRWLDGITDLMDMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL", "length": 473, "header": "tr|A0AAA9RUW4-1|FXL20_BOVIN Computationally mapped isoform of F-box/LRR-repeat protein 20 OS=Bos taurus OX=9913 GN=FBXL20 PE=2 SV=1 CANONICAL=Q58DG6-1" }, "locus": { "chromosome": "19", "start_pos": 39821417, "end_pos": 39744098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114320.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114320.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074752.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074752.1" } ] } }, { "isoform_ac": "A0AAA9SDE2-1", "url": "https://www.uniprot.org/uniprotkb/Q58DG6/entry#A0AAA9SDE2-1", "sequence": { "sequence": "MRRDVNGVTKSRFEMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDAEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL", "length": 404, "header": "tr|A0AAA9SDE2-1|FXL20_BOVIN Computationally mapped isoform of F-box/LRR-repeat protein 20 OS=Bos taurus OX=9913 GN=FBXL20 PE=2 SV=1 CANONICAL=Q58DG6-1" }, "locus": { "chromosome": "19", "start_pos": 39841701, "end_pos": 39744098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106283.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106283.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083427.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083427.1" } ] } }, { "isoform_ac": "A0AAA9SES6-1", "url": "https://www.uniprot.org/uniprotkb/Q58DG6/entry#A0AAA9SES6-1", "sequence": { "sequence": "MQSTEAGEAAAAAAAKAAAALPQSRDYQKGGKWLRAGTACCTLGSRRQIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL", "length": 449, "header": "tr|A0AAA9SES6-1|FXL20_BOVIN Computationally mapped isoform of F-box/LRR-repeat protein 20 OS=Bos taurus OX=9913 GN=FBXL20 PE=2 SV=1 CANONICAL=Q58DG6-1" }, "locus": { "chromosome": "19", "start_pos": 39842606, "end_pos": 39744098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122755.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122755.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084646.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084646.1" } ] } }, { "isoform_ac": "A0AAA9T4K0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DG6/entry#A0AAA9T4K0-1", "sequence": { "sequence": "MAPSRDRLLHFGFKATAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL", "length": 399, "header": "tr|A0AAA9T4K0-1|FXL20_BOVIN Computationally mapped isoform of F-box/LRR-repeat protein 20 OS=Bos taurus OX=9913 GN=FBXL20 PE=2 SV=1 CANONICAL=Q58DG6-1" }, "locus": { "chromosome": "19", "start_pos": 39842511, "end_pos": 39744098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123626.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123626.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091609.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091609.1" } ] } }, { "isoform_ac": "A0AAA9T5P0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DG6/entry#A0AAA9T5P0-1", "sequence": { "sequence": "MLKCIALPSSRGSSWPRDRAHISYVSCIGRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL", "length": 431, "header": "tr|A0AAA9T5P0-1|FXL20_BOVIN Computationally mapped isoform of F-box/LRR-repeat protein 20 OS=Bos taurus OX=9913 GN=FBXL20 PE=2 SV=1 CANONICAL=Q58DG6-1" }, "locus": { "chromosome": "19", "start_pos": 39776275, "end_pos": 39744098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129342.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129342.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093149.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093149.1" } ] } }, { "isoform_ac": "A0AAA9TSZ6-1", "url": "https://www.uniprot.org/uniprotkb/Q58DG6/entry#A0AAA9TSZ6-1", "sequence": { "sequence": "MRRDVNGVTKSRFEMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL", "length": 417, "header": "tr|A0AAA9TSZ6-1|FXL20_BOVIN Computationally mapped isoform of F-box/LRR-repeat protein 20 OS=Bos taurus OX=9913 GN=FBXL20 PE=2 SV=1 CANONICAL=Q58DG6-1" }, "locus": { "chromosome": "19", "start_pos": 39841701, "end_pos": 39744098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115802.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115802.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100187.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100187.1" } ] } }, { "isoform_ac": "Q58DG6-1", "url": "https://www.uniprot.org/uniprotkb/Q58DG6/entry#Q58DG6-1", "sequence": { "sequence": "MRRDVNGVTKSRFEMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL", "length": 436, "header": "sp|Q58DG6-1|FXL20_BOVIN Isoform 1 of F-box/LRR-repeat protein 20 OS=Bos taurus OX=9913 GN=FBXL20 PE=2 SV=2 CANONICAL=Q58DG6-1" }, "locus": { "chromosome": "19", "start_pos": 39841701, "end_pos": 39744098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011020.5", "url": "https://www.ensembl.org/id/ENSBTAT00000011020.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011020.4", "url": "https://www.ensembl.org/id/ENSBTAP00000011020.4" } ] } }, { "isoform_ac": "Q58DG6-2", "url": "https://www.uniprot.org/uniprotkb/Q58DG6/entry#Q58DG6-2", "sequence": { "sequence": "MAPSRDRLLHFGFKATMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL", "length": 438, "header": "sp|Q58DG6-2|FXL20_BOVIN Isoform 2 of F-box/LRR-repeat protein 20 OS=Bos taurus OX=9913 GN=FBXL20 PE=2 SV=2 CANONICAL=Q58DG6-1" }, "locus": { "chromosome": "19", "start_pos": 39842511, "end_pos": 39744098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084210.1", "url": "https://www.ensembl.org/id/ENSBTAT00000084210.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069592.1", "url": "https://www.ensembl.org/id/ENSBTAP00000069592.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 417, "start_aa": "Thr", "end_pos": 417, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr417", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 417, "end_pos": 417, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q58DG6", "url": "https://www.uniprot.org/uniprotkb/Q58DG6" } ], "site_lbl": "Thr417" }, { "start_pos": 421, "end_pos": 421, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DG6", "url": "https://www.uniprot.org/uniprotkb/Q58DG6" } ], "site_lbl": "Ser421" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DG6", "url": "https://www.uniprot.org/uniprotkb/Q58DG6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:511007", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511007", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QU00-1", "protein_name": "F-box/LRR-repeat protein 20", "gene_name": "FBXL20", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVRVQSLAREFLHEMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL", "length": 436 }, "evidence": [ { "id": "Q58DG6", "url": "https://omabrowser.org/oma/group/Q58DG6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZM14-1", "protein_name": "F-box and leucine rich repeat protein 20", "gene_name": "FBXL20", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRRAAEPVPPGPSHTHGRWGEDISLSTCTHSTTTTTTIIIIIVAARAGREPSIAVLTHNWRPWKRDSSALNQMFSNNDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCQGVGDNALRTFAQNCRNIEVLNLNGCTKITDATCTSLSKFCSKLRHLDLASCTSITNLSLKALSEGCPLLEQLNISWCDQVTKDGVQALVRGCGGLKALSLKGCTQLEDEALKYIGANCPELVTLNLQTCLQITDDGLITICRGCHKLQSLCASGCCNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHDLEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDRLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL", "length": 494 }, "evidence": [ { "id": "Q58DG6", "url": "https://omabrowser.org/oma/group/Q58DG6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A8DYA6-1", "protein_name": "F-box domain-containing protein", "gene_name": "Dmel\\CG9003", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": 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"sequence": "MGKEVNGVSRSRFEMFSNNDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRSWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDSALRTFAQNCRNIELLSLNGCTKITDSTCNSLSKFCPKLKHLDLASCTSITNLSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRCCPGLKGLFLKGCTQLEDEALKHIGGHCPELVTLNLQTCSQITDEGLITICRGCHRLQSLCVSGCANITDAILNALGQNCPRLRILEVARCSQLTDVGFTSLARNCHELEKMDLEECVQITDATLIQLSIHCPRLQVLSLSHCELITDDGIRQLGSGPCAHDRLEVIELDNCPLITDASLEHLKSCHSLDRIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCVLL", "length": 436 }, "evidence": [ { "id": "Q58DG6", "url": "https://omabrowser.org/oma/group/Q58DG6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q96IG2-1", "protein_name": "F-box/LRR-repeat protein 20", "gene_name": "FBXL20", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRRDVNGVTKSRFEMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL", "length": 436 }, "evidence": [ { "id": "Q58DG6", "url": "https://omabrowser.org/oma/group/Q58DG6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58DG6", "url": "https://www.uniprot.org/uniprotkb/Q58DG6" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "Q58DG6", "url": "https://www.uniprot.org/uniprotkb/Q58DG6" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "Q58DG6", "url": "https://www.uniprot.org/uniprotkb/Q58DG6" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "Q58DG6", "url": "https://www.uniprot.org/uniprotkb/Q58DG6" } ], "pmid": "" }, { "name": "Schaffer collateral - CA1 synapse", "id": "GO:0098685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098685", "evidence": [ { "database": "UniProtKB", "id": "Q58DG6", "url": "https://www.uniprot.org/uniprotkb/Q58DG6" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q58DG6", "url": "https://www.uniprot.org/uniprotkb/Q58DG6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "Q58DG6", "url": "https://www.uniprot.org/uniprotkb/Q58DG6" } ], "pmid": "" }, { "name": "regulation of synaptic vesicle exocytosis", "id": "GO:2000300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000300", "evidence": [ { "database": "UniProtKB", "id": "Q58DG6", "url": "https://www.uniprot.org/uniprotkb/Q58DG6" } ], "pmid": "" }, { "name": "regulation of protein catabolic process at presynapse, modulating synaptic transmission", "id": "GO:0099575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099575", "evidence": [ { "database": "UniProtKB", "id": "Q58DG6", "url": "https://www.uniprot.org/uniprotkb/Q58DG6" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q58DG6", "url": "https://www.uniprot.org/uniprotkb/Q58DG6" } ], "pmid": "" }, { "name": "regulation of defense response", "id": "GO:0031347", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031347", "evidence": [ { "database": "UniProtKB", "id": "Q58DG6", "url": "https://www.uniprot.org/uniprotkb/Q58DG6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "Q58DG6", "url": "https://www.uniprot.org/uniprotkb/Q58DG6" } ], "pmid": "" }, { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "Q58DG6", "url": "https://www.uniprot.org/uniprotkb/Q58DG6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" }, { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 259, "end_pos": 261, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DG6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 436, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DG6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DG6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58DG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DG6" }, { "id": "PRU00080", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00080" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000255", "start_pos": 22, "end_pos": 68, "start_aa": "Ala", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 417 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 417, 421 ], "sequon_annotation_sites": [ { "start_pos": 158, "end_pos": 160 }, { "start_pos": 175, "end_pos": 177 }, { "start_pos": 259, "end_pos": 261 }, { "start_pos": 84, "end_pos": 86 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { 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"kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9C4-1", "uniprot_ac": "Q5E9C4", "uniprot_id": "TBCD7_BOVIN", "mass": { "chemical_mass": 33904.0, "monoisotopic_mass": 33904.0 }, "refseq": { "ac": "NP_001015643", "name": "TBC1 domain family member 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015643" }, "gene_names": [ { "name": "TBC1D7", "type": "recommended", "evidence": [ { "id": "Q5E9C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9C4" } ] }, { "name": "TBC1D7", "type": "synonym", "evidence": [ { "id": "NP_001015643", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015643" } ] } ], "protein_names": [ { "name": "TBC1 domain family member 7", "type": "recommended", "evidence": [ { "id": "Q5E9C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9C4/entry#names_and_taxonomy" } ] }, { "name": "TBC1 domain family member 7", "type": "synonym", "evidence": [ { "id": "NP_001015643", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015643" } ] } ], "function": [ { "annotation": "Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule 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The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C4", "url": "https://www.uniprot.org/uniprotkb/Q5E9C4#function" }, { "database": "UniProtKB", "id": "Q9P0N9", "url": "https://www.uniprot.org/uniprotkb/Q9P0N9#function" }, { "database": "UniProtKB", "id": "A0A3Q1M3U3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3U3#function" }, { "database": "UniProtKB", "id": "ARBA00046045", "url": "https://www.uniprot.org/uniprotkb/ARBA00046045#function" }, { "database": "UniProtKB", "id": "A0AAA9TR79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR79#function" }, { "database": "UniProtKB", "id": "A0ABI0NZH2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZH2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9C4", "url": "https://www.uniprot.org/uniprotkb/Q5E9C4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBC1D7", "url": "https://www.uniprot.org/uniprotkb/Q5E9C4", "locus": { "chromosome": "23", "start_pos": 43247438, "end_pos": 43223858, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017160", "url": "https://www.ensembl.org/id/ENSBTAG00000017160" } ] } } ], "crossref": [ { "id": "Q5E9C4", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9C4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017160", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017160", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532704", "url": "https://www.ncbi.nlm.nih.gov/gene/532704", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039842", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039842", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532704", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532704", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VMHTMWL", "url": "https://omabrowser.org/oma/group/VMHTMWL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M3U3", "url": "https://www.orthodb.org/?gene=A0A3Q1M3U3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5E9C4", "url": "https://www.orthodb.org/?gene=Q5E9C4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13530", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13530", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13530:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13530:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00566", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00566", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8854214", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854214", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015643", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3U3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3U3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3U3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3U3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TR79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TR79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR79-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZH2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZH2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9C4", "url": "https://www.uniprot.org/uniprotkb/Q5E9C4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9C4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9C4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTEDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDIEKLCTFSQRFPLPSMYRALVWKVLLGILPPHHESHVQVMTYRKEQYSDVLHALKVIRFVSDATPQSEVYLYMHRLESGKLPRSPSFPLEPEDEVFLAIAKAMEEMVEDSVDCYWIMRCFVNQLNSKYRDTLPQLPKAFEQYLNLEDSRLLSHLKACCAVSTLPYELWFKKCFAGCLPESSLQRIWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVSKAIDLWHKHCGTPVHSA", "length": 293, "header": "sp|Q5E9C4-1|TBCD7_BOVIN Isoform 1 of TBC1 domain family member 7 OS=Bos taurus OX=9913 GN=TBC1D7 PE=2 SV=2 CANONICAL=Q5E9C4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M3U3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9C4/entry#A0A3Q1M3U3-1", "sequence": { "sequence": "MTEDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLGILPPHHESHVQVMTYRKEQYSDVLHALKVIRFVSDATPQSEVYLYMHRLESGKLPRSPSFPLEPEDEVFLAIAKAMEEMVEDSVDCYWIMRCFVNQLNSKYRDTLPQLPKAFEQYLNLEDSRLLSHLKACCAVSTLPYELWFKKCFAGCLPESSLQRIWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVSKAIDLWHKHCGTPVHSA", "length": 266, "header": "tr|A0A3Q1M3U3-1|TBCD7_BOVIN Computationally mapped isoform of TBC1 domain family member 7 OS=Bos taurus OX=9913 GN=TBC1D7 PE=2 SV=1 CANONICAL=Q5E9C4-1" }, "locus": { "chromosome": "23", "start_pos": 43246743, "end_pos": 43225542, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072555.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072555.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064445.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064445.1" } ] } }, { "isoform_ac": "A0AAA9TR79-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9C4/entry#A0AAA9TR79-1", "sequence": { "sequence": "MTEDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDIEKLCTFSQRFPLPSMYRALVWKVLLGILPPHHESHVQVMTYRKEQYSDVLHALKVIRFVSDATPQSEVYLYMHRLESGKLPRSPSFPLPKAFEQYLNLEDSRLLSHLKACCAVSTLPYELWFKKCFAGCLPESSLQRIWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVSKAIDLWHKHCGTPVHSA", "length": 247, "header": "tr|A0AAA9TR79-1|TBCD7_BOVIN Computationally mapped isoform of TBC1 domain family member 7 OS=Bos taurus OX=9913 GN=TBC1D7 PE=2 SV=1 CANONICAL=Q5E9C4-1" }, "locus": { "chromosome": "23", "start_pos": 43246743, "end_pos": 43225542, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107405.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107405.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099815.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099815.1" } ] } }, { "isoform_ac": "A0ABI0NZH2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9C4/entry#A0ABI0NZH2-1", "sequence": { "sequence": "MTEDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDIEKLCTFSQRFPLPSMYRALVWKVLLGILPPHHESHVQVMTYRKEQYSDVLHALKVIRFVSDATPQSEVYLYMHRLESGKLPRSPSFPLEPEDEVFLAIAKAMEEMVEDSVDCYWIMRCFVNQLNSKYRDTLPQLPKAFEQYLNLEDSRLLSHLKACCAVSTLPYELWFKKCFAGCLPESSLQRIWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENRSPLPLKNFDSSRGREQKCMRRSSCHRRLLPSE", "length": 298, "header": "tr|A0ABI0NZH2-1|A0ABI0NZH2_BOVIN Computationally mapped isoform of TBC1 domain family member 7 OS=Bos taurus OX=9913 GN=TBC1D7 PE=4 SV=1 CANONICAL=Q5E9C4-1" }, "locus": { "chromosome": "23", "start_pos": 43248542, "end_pos": 43225542, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000144099.1", "url": "https://www.ensembl.org/id/ENSBTAT00000144099.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106640.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106640.1" } ] } }, { "isoform_ac": "Q5E9C4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9C4/entry#Q5E9C4-1", "sequence": { "sequence": "MTEDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDIEKLCTFSQRFPLPSMYRALVWKVLLGILPPHHESHVQVMTYRKEQYSDVLHALKVIRFVSDATPQSEVYLYMHRLESGKLPRSPSFPLEPEDEVFLAIAKAMEEMVEDSVDCYWIMRCFVNQLNSKYRDTLPQLPKAFEQYLNLEDSRLLSHLKACCAVSTLPYELWFKKCFAGCLPESSLQRIWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVSKAIDLWHKHCGTPVHSA", "length": 293, "header": "sp|Q5E9C4-1|TBCD7_BOVIN Isoform 1 of TBC1 domain family member 7 OS=Bos taurus OX=9913 GN=TBC1D7 PE=2 SV=2 CANONICAL=Q5E9C4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C4", "url": "https://www.uniprot.org/uniprotkb/Q5E9C4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "A whole-genome assembly of the domestic cow, Bos taurus.", "journal": "Genome Biol.", "date": "2009", "authors": "Zimin Aleksey V, Delcher Arthur L, Florea Liliana, Kelley David R, Schatz Michael C, Puiu Daniela, Hanrahan Finnian, Pertea Geo, Van Tassell Curtis P, Sonstegard Tad S, Mar\u00e7ais Guillaume, Roberts Michael, Subramanian Poorani, Yorke James A, Salzberg Steven L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C4", "url": "https://www.uniprot.org/uniprotkb/Q5E9C4" } ], "reference": [ { "type": "PubMed", "id": "19393038", "url": "https://glygen.org/publication/PubMed/19393038" } ] } ], "pathway": [ { "id": "bta:532704", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532704", "resource": "KEGG Pathway" }, { "id": "R-BTA-8854214", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854214", "resource": "Reactome", "description": "TBC/RABGAPs" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A809-1", "protein_name": "TBC1 domain family member 7", "gene_name": "TBC1D7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTDDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDIEKLCTFSQRFPLPSLYRALVWKVLLGILPPHHESHARVMAYRKEQYSDVLHALDVIRFVSDATPQVEVFLYMHRLESGKLPRSPSFPLEPEDEVFLAIAKAMEEMVEDSVDCYWITRCFVNQLDSKYRDFLPQLPKAFEQYLNLEDSRLLSHLKACSAVSRLPYDLWFKRCFAGCLPEPSLQRVWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVSKAIDLWHKHCGTPVHSA", "length": 293 }, "evidence": [ { "id": "Q5E9C4", "url": "https://omabrowser.org/oma/group/Q5E9C4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MTP9-1", "protein_name": "TBC1 domain family member 7", "gene_name": "LOC100767925", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTDDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDPLDIEKLCTFSQRFPLPSMYRALVWKVLLGILPPHHDSHAQVMAYRKDQYSDVLHALTVVRFISDATPQVEVYLRMYQLESGKLPRSPSFPMEPEDEVFLAIAKAMEEMVEDSIDCYWLTRCFVKQLHSKFRDSLPQLPKAFEQYLNLEDSRLLSHLKTCSAVSKLPYDLWFKRCFAGCLPESSLQRVWDKVVSGSCKILVFVAVEILLTFKIKVMALNSVEKITEFLENIPQDSSDAIVSKAIDLWHKHCGTPAHSA", "length": 293 }, "evidence": [ { "id": "Q5E9C4", "url": "https://omabrowser.org/oma/group/Q5E9C4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0ABK0M1L8-1", "protein_name": "TBC1 domain family member 7", "gene_name": "Tbc1d7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTDDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDVASWFLGKLKESRLWFPFVEDIEKLCTFSQRFPLPSMYRVLVWKVLLGILPPHHDSHAQVMAYRKDQYSDVLHALTVVRFISDATPQGEVYLRMYQLESGKLPRSPSFPLELEDEVFLAIAKAMEEMVEDSVDCYWITRCFVKQFNNKYRDALPQLPRAFEQYLNLEDSRLLSHLKTCSAVSKLPYDLWFKRCFAGCLPESSLQRVWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVSKAIDLWHKHCGTPVHSA", "length": 314 }, "evidence": [ { "id": "Q5E9C4", "url": "https://omabrowser.org/oma/group/Q5E9C4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1QRX7-1", "protein_name": "TBC1 domain family member 7", "gene_name": "tbc1d7", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MADDPQRNFRSAYYEKVGFRGVEEKKSLEILLKDNPLDVEKLSTFSQRFPLPSMYRIHVWKVLLGILPPHSDSHALVRQYRVDQFEDVSCALTVMRFIHASTPQTEIYLRMFQLENHTLPRRTELRPPDAEDENFLAIARAMEEIVDDPVDCFWLVRCFINQFKHKFGDSIPHLPKSLEHFLSQEDVCLLSHLKASGALALLPYSLWFRRCFAGCLPESSLQRVWDKVISGSCKILVFVAVEILLSHKIVIMGMNQPDAIYHFLSNMPQENTDAIVTKAIDLWHKYCGTPMHSV", "length": 294 }, "evidence": [ { "id": "Q5E9C4", "url": "https://omabrowser.org/oma/group/Q5E9C4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9D0K0-1", "protein_name": "TBC1 domain family member 7", "gene_name": "Tbc1d7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTDDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDIEKLCTFSQRFPLPSMYRALVWKALLGILPPHHDTHSQVMAYRKDQYHDILHALTVVRFISDATPQAEVYLRMYQLESGKLPRSPSFPLEPEDEVFLAIAKAMEEMVEDSVDCYWISRCFVKQLNNKYRDALPQLPKAFEQYLNLEDSRLLSHLKTCSAVSKLPYDLWFQRCFAGCLPESSLQRVWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVSKAIDLWHKHCGTPVHSA", "length": 293 }, "evidence": [ { "id": "Q5E9C4", "url": "https://omabrowser.org/oma/group/Q5E9C4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P0N9-1", "protein_name": "TBC1 domain family member 7", "gene_name": "TBC1D7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTEDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDTEKLCTFSQRFPLPSMYRALVWKVLLGILPPHHESHAKVMMYRKEQYLDVLHALKVVRFVSDATPQAEVYLRMYQLESGKLPRSPSFPLEPDDEVFLAIAKAMEEMVEDSVDCYWITRRFVNQLNTKYRDSLPQLPKAFEQYLNLEDGRLLTHLRMCSAAPKLPYDLWFKRCFAGCLPESSLQRVWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVSKAIDLWHKHCGTPVHSS", "length": 293 }, "evidence": [ { "id": "Q5E9C4", "url": "https://omabrowser.org/oma/group/Q5E9C4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VCC4-1", "protein_name": "TBC1 domain family member 7", "gene_name": "TBC1d7", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNTDERNFRSIYYEKCQINSVEEQKSLNKLLQDDIRNLSKLKQFCMNYTVPNNNRSYLWALVMGILPLHKASTAYVRDQRREMYEDLRRAVTVLRFTDHKQKEQPFMWLIDHKKKAQVMHTMWLIESNRLWHGNTSASLQADDMHFIEIVRTLLQIFDDNVETYWIAKGFYKYTRELKKECVKLKEQTQNILKREDLSLLNHLELLGLFDGNSTLLDNWYITCFAGIICTTHLVKIWDKVCGGSRKIVVFLFVELVKDIRSSILKQTSLADVKRLIETVKDLDGVIIVNKAIKSLQNNSSEVEYTH", "length": 306 }, "evidence": [ { "id": "Q5E9C4", "url": "https://omabrowser.org/oma/group/Q5E9C4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "TSC1-TSC2 complex", "id": "GO:0033596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033596", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C4", "url": "https://www.uniprot.org/uniprotkb/Q5E9C4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C4", "url": "https://www.uniprot.org/uniprotkb/Q5E9C4" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C4", "url": "https://www.uniprot.org/uniprotkb/Q5E9C4" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C4", "url": "https://www.uniprot.org/uniprotkb/Q5E9C4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C4", "url": "https://www.uniprot.org/uniprotkb/Q5E9C4" } ], "pmid": "" }, { "name": "TSC1-TSC2 complex binding", "id": "GO:0062078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062078", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C4", "url": "https://www.uniprot.org/uniprotkb/Q5E9C4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "positive regulation of protein ubiquitination", "id": "GO:0031398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031398", "evidence": [ { "database": "UniProtKB", "id": "Q5E9C4", "url": 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"UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3X3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3X3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MKJ8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MKJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQ12", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQ12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQ12-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQ12-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVX8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T949", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T949", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T949-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T949-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TU45", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TU45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU45-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DD4", "url": "https://www.uniprot.org/uniprotkb/Q58DD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DD4-1", "url": "https://www.uniprot.org/uniprotkb/Q58DD4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRAWILLTWVLVACVSAESRAELTSDKDMYLDNNSIEEASGVYPIDDDDYASASGSGAGEDGESPELTTSRPIPKIPFTSTAPRVETTTLSKIQDKIPAQTKSPEEIDKEKVHLPDSERKTDPAEEDTNVYTEKHSDNLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA", "length": 202, "header": "sp|Q58DD4-1|SDC2_BOVIN Isoform 1 of Syndecan-2 OS=Bos taurus OX=9913 GN=SDC2 PE=2 SV=1 CANONICAL=Q58DD4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M3X3-1", "url": "https://www.uniprot.org/uniprotkb/Q58DD4/entry#A0A3Q1M3X3-1", "sequence": { "sequence": "MYILRGERAELTSDKDMYLDNNSIEEASGVYPIDDDDYASASGSGAGEDGESPELTTSRPIPKIPFTSTAPRVETTTLSKIQDKIPAQTKSPEEIDKEKVHLPDSERKTDPAEEDTNVYTEKHSDNLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA", "length": 189, "header": "tr|A0A3Q1M3X3-1|SDC2_BOVIN Computationally mapped isoform of Syndecan-2 OS=Bos taurus OX=9913 GN=SDC2 PE=2 SV=2 CANONICAL=Q58DD4-1" }, "locus": { "chromosome": "14", "start_pos": 67612300, "end_pos": 67588319, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072257.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072257.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062912.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062912.2" } ] } }, { "isoform_ac": "A0A3Q1MKJ8-1", "url": "https://www.uniprot.org/uniprotkb/Q58DD4/entry#A0A3Q1MKJ8-1", "sequence": { "sequence": "MWAGLPGLYLSRAELTSDKDMYLDNNSIEEASGVYPIDDDDYASASGSGAGEDGESPELTTSRPIPKIPFTSTAPRVETTTLSKIQDKIPAQTKSPEEIDKEKVHLPDSERKTDPAEEDTNVYTEKHSDNLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA", "length": 193, "header": "tr|A0A3Q1MKJ8-1|SDC2_BOVIN Computationally mapped isoform of Syndecan-2 OS=Bos taurus OX=9913 GN=SDC2 PE=2 SV=3 CANONICAL=Q58DD4-1" }, "locus": { "chromosome": "14", "start_pos": 67617917, "end_pos": 67588319, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084329.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084329.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071416.3", "url": "https://www.ensembl.org/id/ENSBTAP00000071416.3" } ] } }, { "isoform_ac": "A0A3Q1MQ12-1", "url": "https://www.uniprot.org/uniprotkb/Q58DD4/entry#A0A3Q1MQ12-1", "sequence": { "sequence": "QSAEAWTEDERTQRSRGAEPPVATGPRSCQSGRNPGGISPGFRWESHCRLLSSGGPEESGEAGWGGKREGEGGGGRERRRRRTRGGRRRRGRRRRRRRGAAAEPLARLGRATLQILRELQPRGSRAPAALPPNFSCSYIRSHLIYSSKKSETEQRHREGVRGGVKPQQSNKILRAASPARSHNPASGVEEPTSEKAPRSRGAAGGSGRSGARSPPSPLEPPEQRSLRQLCSGSFCASSAGRWARSFVFSLVASGRLGATGPGGICGALGSCSPGSWWPACPPSRKAPLAEVTLRSPGMRAKVLPFCRTAEAAEERAELTSDKDMYLDNNSIEEASGVYPIDDDDYASASGSGAGEDGESPELTTSRPIPKIPFTSTAPRVETTTLSKIQDKIPAQTKSPEEIDKEKVHLPDSERKTDPAEEDTNVYTEKHSDNLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA", "length": 496, "header": "tr|A0A3Q1MQ12-1|SDC2_BOVIN Computationally mapped isoform of Syndecan-2 OS=Bos taurus OX=9913 GN=SDC2 PE=2 SV=1 CANONICAL=Q58DD4-1" }, "locus": { "chromosome": "14", "start_pos": 67708225, "end_pos": 67588319, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069051.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069051.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071799.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071799.1" } ] } }, { "isoform_ac": "A0AAA9SVX8-1", "url": "https://www.uniprot.org/uniprotkb/Q58DD4/entry#A0AAA9SVX8-1", "sequence": { "sequence": "MKLCFPLMPNPENWLLMLRAELTSDKDMYLDNNSIEEASGVYPIDDDDYASASGSGAGEDGESPELTTSRPIPKIPFTSTAPRVETTTLSKIQDKIPAQTKSPEEIDKEKVHLPDSERKTDPAEEDTNVYTEKHSDNLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA", "length": 200, "header": "tr|A0AAA9SVX8-1|SDC2_BOVIN Computationally mapped isoform of Syndecan-2 OS=Bos taurus OX=9913 GN=SDC2 PE=2 SV=1 CANONICAL=Q58DD4-1" }, "locus": { "chromosome": "14", "start_pos": 67619316, "end_pos": 67588319, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098548.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098548.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090637.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090637.1" } ] } }, { "isoform_ac": "A0AAA9T949-1", "url": "https://www.uniprot.org/uniprotkb/Q58DD4/entry#A0AAA9T949-1", "sequence": { "sequence": "MKRAELTSDKDMYLDNNSIEEASGVYPIDDDDYASASGSGAGEDGESPELTTSRPIPKIPFTSTAPRVETTTLSKIQDKIPAQTKSPEEIDKEKVHLPDSERKTDPAEEDTNVYTEKHSDNLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA", "length": 184, "header": "tr|A0AAA9T949-1|SDC2_BOVIN Computationally mapped isoform of Syndecan-2 OS=Bos taurus OX=9913 GN=SDC2 PE=2 SV=1 CANONICAL=Q58DD4-1" }, "locus": { "chromosome": "14", "start_pos": 67618238, "end_pos": 67588319, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114126.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114126.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093376.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093376.1" } ] } }, { "isoform_ac": "A0AAA9TAQ5-1", "url": "https://www.uniprot.org/uniprotkb/Q58DD4/entry#A0AAA9TAQ5-1", "sequence": { "sequence": "MRWLDSVTDSVDRAELTSDKDMYLDNNSIEEASGVYPIDDDDYASASGSGAGEDGESPELTTSRPIPKIPFTSTAPRVETTTLSKIQDKIPAQTKSPEEIDKEKVHLPDSERKTDPAEEDTNVYTEKHSDNLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA", "length": 194, "header": "tr|A0AAA9TAQ5-1|SDC2_BOVIN Computationally mapped isoform of Syndecan-2 OS=Bos taurus OX=9913 GN=SDC2 PE=2 SV=1 CANONICAL=Q58DD4-1" }, "locus": { "chromosome": "14", "start_pos": 67691468, "end_pos": 67588319, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114188.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114188.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095080.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095080.1" } ] } }, { "isoform_ac": "A0AAA9TQZ2-1", "url": "https://www.uniprot.org/uniprotkb/Q58DD4/entry#A0AAA9TQZ2-1", "sequence": { "sequence": "MSLTLDWLDLTVSGLGHEHHRWNYKWRKRLNPLDGAGKGLAPQRAELTSDKDMYLDNNSIEEASGVYPIDDDDYASASGSGAGEDGESPELTTSRPIPKIPFTSTAPRVETTTLSKIQDKIPAQTKSPEEIDKEKVHLPDSERKTDPAEEDTNVYTEKHSDNLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA", "length": 225, "header": "tr|A0AAA9TQZ2-1|SDC2_BOVIN Computationally mapped isoform of Syndecan-2 OS=Bos taurus OX=9913 GN=SDC2 PE=2 SV=1 CANONICAL=Q58DD4-1" }, "locus": { "chromosome": "14", "start_pos": 67688091, "end_pos": 67588319, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113200.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113200.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099748.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099748.1" } ] } }, { "isoform_ac": "A0AAA9TU45-1", "url": "https://www.uniprot.org/uniprotkb/Q58DD4/entry#A0AAA9TU45-1", "sequence": { "sequence": "MTSSLEKRAELTSDKDMYLDNNSIEEASGVYPIDDDDYASASGSGAGEDGESPELTTSRPIPKIPFTSTAPRVETTTLSKIQDKIPAQTKSPEEIDKEKVHLPDSERKTDPAEEDTNVYTEKHSDNLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA", "length": 189, "header": "tr|A0AAA9TU45-1|SDC2_BOVIN Computationally mapped isoform of Syndecan-2 OS=Bos taurus OX=9913 GN=SDC2 PE=2 SV=1 CANONICAL=Q58DD4-1" }, "locus": { "chromosome": "14", "start_pos": 67677329, "end_pos": 67588319, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114050.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114050.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101894.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101894.1" } ] } }, { "isoform_ac": "Q58DD4-1", "url": "https://www.uniprot.org/uniprotkb/Q58DD4/entry#Q58DD4-1", "sequence": { "sequence": "MRRAWILLTWVLVACVSAESRAELTSDKDMYLDNNSIEEASGVYPIDDDDYASASGSGAGEDGESPELTTSRPIPKIPFTSTAPRVETTTLSKIQDKIPAQTKSPEEIDKEKVHLPDSERKTDPAEEDTNVYTEKHSDNLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA", "length": 202, "header": "sp|Q58DD4-1|SDC2_BOVIN Isoform 1 of Syndecan-2 OS=Bos taurus OX=9913 GN=SDC2 PE=2 SV=1 CANONICAL=Q58DD4-1" }, "locus": { "chromosome": "14", "start_pos": 67707434, "end_pos": 67588319, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019090.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019090.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019090.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019090.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "S", "relation": "attached", "comment": "O-linked (Xyl...) (glycosaminoglycan) serine", "icn3d_view": {}, "start_pos": 41, "start_aa": "Ser", "end_pos": 41, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser41", "evidence": [ { "id": "Q58DD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DD4#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "S", "relation": "attached", "comment": "O-linked (Xyl...) (glycosaminoglycan) serine", "icn3d_view": {}, "start_pos": 55, "start_aa": "Ser", "end_pos": 55, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser55", "evidence": [ { "id": "Q58DD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DD4#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "S", "relation": "attached", "comment": "O-linked (Xyl...) (glycosaminoglycan) serine", "icn3d_view": {}, "start_pos": 57, "start_aa": "Ser", "end_pos": 57, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser57", "evidence": [ { "id": "Q58DD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DD4#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 188, "end_pos": 188, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DD4", "url": "https://www.uniprot.org/uniprotkb/Q58DD4" } ], "site_lbl": "Ser188" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DD4", "url": "https://www.uniprot.org/uniprotkb/Q58DD4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:615785", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615785", "resource": "KEGG Pathway" }, { "id": "R-BTA-1971475", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1971475", "resource": "Reactome", "description": "Glycosaminoglycan-protein linkage region biosynthesis" }, { "id": "R-BTA-2022928", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022928", "resource": "Reactome", "description": "HS-GAG biosynthesis" }, { "id": "R-BTA-2024096", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2024096", "resource": "Reactome", "description": "HS-GAG degradation" }, { "id": "R-BTA-3000170", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3000170", "resource": "Reactome", "description": "Syndecan interactions" }, { "id": "R-BTA-381426", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "resource": "Reactome", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" }, { "id": "R-BTA-3928662", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928662", "resource": "Reactome", "description": "EPHB-mediated forward signaling" }, { "id": "R-BTA-8957275", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "resource": "Reactome", "description": "Post-translational protein phosphorylation" }, { "id": "R-BTA-975634", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975634", "resource": "Reactome", "description": "Retinoid metabolism and transport" }, { "id": "R-BTA-9769735", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9769735", "resource": "Reactome", "description": "Initiation of coagulation cascade" }, { "id": "R-BTA-9769739", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9769739", "resource": "Reactome", "description": "Regulation of clotting cascade" } ], "orthologs": [ { "uniprot_canonical_ac": "F1S0L5-1", "protein_name": "Syndecan", "gene_name": "SDC2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRRVWILLTLGLVACVSAESRAELTSDKDMYLDNSSIEEASGVYPIDDDDYASASGSGADEDVESPELTTSRPLPKIPITSAAPRVETTTLDKMQNKIPAQTKSPEEIDKEKVHLSDSERKTDPAEEDTNVYTEKHSDNLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA", "length": 202 }, "evidence": [ { "id": "Q58DD4", "url": "https://omabrowser.org/oma/group/Q58DD4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "Q58DD4", "url": "https://www.uniprot.org/uniprotkb/Q58DD4" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q58DD4", "url": "https://www.uniprot.org/uniprotkb/Q58DD4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "Q58DD4", "url": "https://www.uniprot.org/uniprotkb/Q58DD4" } ], "pmid": "" }, { "name": "regulation of dendrite morphogenesis", "id": "GO:0048814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048814", "evidence": [ { "database": "UniProtKB", "id": "Q58DD4", "url": "https://www.uniprot.org/uniprotkb/Q58DD4" } ], "pmid": "" }, { "name": "dendrite morphogenesis", "id": "GO:0048813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048813", "evidence": [ { "database": "UniProtKB", "id": "Q58DD4", "url": "https://www.uniprot.org/uniprotkb/Q58DD4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DD4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 202, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DD4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DD4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 41, 55, 57 ], 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"monoisotopic_mass": 33829.0 }, "refseq": { "ac": "NP_001014881", "name": "inactive C-alpha-formylglycine-generating enzyme 2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014881" }, "gene_names": [ { "name": "SUMF2", "type": "recommended", "evidence": [ { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2" } ] }, { "name": "SUMF2", "type": "synonym", "evidence": [ { "id": "NP_001014881", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014881" } ] } ], "protein_names": [ { "name": "Inactive C-alpha-formylglycine-generating enzyme 2", "type": "recommended", "evidence": [ { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2/entry#names_and_taxonomy" } ] }, { "name": "C-alpha-formylglycine-generating enzyme 2", "type": "synonym", "evidence": [ { "id": "NP_001014881", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014881" } ] }, { "name": "Sulfatase-modifying factor 2", "type": "synonym", "evidence": [ { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2/entry#names_and_taxonomy" } ] }, { "name": "inactive C-alpha-formylglycine-generating enzyme 2 precursor", "type": "synonym", "evidence": [ { "id": "NP_001014881", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014881" } ] }, { "name": "inactive C-alpha-formylglycine-generating enzyme 2", "type": "synonym", "evidence": [ { "id": "NP_001014881", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014881" } ] } ], "function": [ { "annotation": "Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1.", "evidence": [ { "database": "UniProtKB", "id": "Q58CP2", "url": "https://www.uniprot.org/uniprotkb/Q58CP2#function" }, { "database": "UniProtKB", "id": "Q8NBJ7", "url": "https://www.uniprot.org/uniprotkb/Q8NBJ7#function" }, { "database": "UniProtKB", "id": "A0A3Q1M497", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M497#function" }, { "database": "UniProtKB", "id": "ARBA00056360", "url": "https://www.uniprot.org/uniprotkb/ARBA00056360#function" }, { "database": "UniProtKB", "id": "A0AAA9RYE8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYE8#function" }, { "database": "UniProtKB", "id": "A0AAA9S5G4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CP2", "url": "https://www.uniprot.org/uniprotkb/Q58CP2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SUMF2", "url": "https://www.uniprot.org/uniprotkb/Q58CP2", "locus": { "chromosome": "25", "start_pos": 27754859, "end_pos": 27738640, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008190", "url": "https://www.ensembl.org/id/ENSBTAG00000008190" } ] } } ], "crossref": [ { "id": "Q58CP2", "url": "https://alphafold.ebi.ac.uk/entry/Q58CP2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008190", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008190", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "509497", "url": "https://www.ncbi.nlm.nih.gov/gene/509497", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005532", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005532", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051043", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051043", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509497", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509497", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CVRYRAS", "url": "https://omabrowser.org/oma/group/CVRYRAS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M497", "url": "https://www.orthodb.org/?gene=A0A3Q1M497", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q58CP2", "url": "https://www.orthodb.org/?gene=Q58CP2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23150", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23150", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23150:SF33", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23150:SF33", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03781", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03781", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1663150", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1663150", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9840310", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9840310", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001014881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014881", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M497", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M497", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M497-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M497-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYE8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYE8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYE8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5G4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5G4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CP2", "url": "https://www.uniprot.org/uniprotkb/Q58CP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CP2-1", "url": "https://www.uniprot.org/uniprotkb/Q58CP2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGISLSPLLTVLSLLSGRWLELGNGQTVNMVQLPGGRFQMGTDSPDGRDGEGPVREVTVKPFAIDIFPVTNKDFREFVREKKYRTEAEVFGWSFVFEDLVSDELRNKATQRMQSLLWWLPVERAFWRQPAGPGSGIREKLEFPVVHVSWNDARAYCAWRGKRLPTEEEWEFAARGGLKGQVYPWGNKFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPPQNDYGLYDLVGNVWEWTASQYQAADQDMRVLRGASWIDTADGSANHRARVTTRMGNTPDSASDNLGFRCASGAGRPPGEL", "length": 301, "header": "sp|Q58CP2-1|SUMF2_BOVIN Isoform 1 of Inactive C-alpha-formylglycine-generating enzyme 2 OS=Bos taurus OX=9913 GN=SUMF2 PE=2 SV=1 CANONICAL=Q58CP2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M497-1", "url": "https://www.uniprot.org/uniprotkb/Q58CP2/entry#A0A3Q1M497-1", "sequence": { "sequence": "MGISLSPLLTVLSLLSGRWLELGNGQTVNMVQLPGGRFQMGTDSPDGRDGEGPVREVTVKPFAIDIFPVTNKDFREFVREKKYRTEAEVFGWSFVFEDLVSDELRNKATQRMQSLLWWLPVERAFWRQPAGPGSGIREKLEFPVVHVSWNDARAYCAWRGKRLPTEEEWEFAARGGLKGQVYPWGNKFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPPQNDYGLYDLVGNVWEWTASQYQAADQDMRVLRGASWIDTADGSANHRARVTTRFFLAELLV", "length": 282, "header": "tr|A0A3Q1M497-1|SUMF2_BOVIN Computationally mapped isoform of Inactive C-alpha-formylglycine-generating enzyme 2 OS=Bos taurus OX=9913 GN=SUMF2 PE=2 SV=2 CANONICAL=Q58CP2-1" }, "locus": { "chromosome": "25", "start_pos": 27748218, "end_pos": 27738682, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076550.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076550.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065016.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065016.2" } ] } }, { "isoform_ac": "A0AAA9RYE8-1", "url": "https://www.uniprot.org/uniprotkb/Q58CP2/entry#A0AAA9RYE8-1", "sequence": { "sequence": "MGISLSPLLTVLSLLSGRWLELGNGQTVNMVQLPGGRFQMGTDSPDGRDGEGPVREVTVKPFAIDIFPVTNKDFREFVREKKYRTEAEVFGWSFVFEDLVSDELRNKATQRMQSLLWWLPVERAFWRQPAGPGSGIREKLEFPVVHVSWNDARAYCAWRGKRLPTEEEWEFAARGGLKGQVYPWGNKFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPPQNDYGLYDLVGNVWEWTASQYQAADQDMRVLRGASWIDTADGSANHRARVTTRMGNTPDSASDNLGFRCASGAGRPPGELAEGRGLELNPGSRKLELGAPSLRALRRRGPWVAGDSLGVSG", "length": 342, "header": "tr|A0AAA9RYE8-1|SUMF2_BOVIN Computationally mapped isoform of Inactive C-alpha-formylglycine-generating enzyme 2 OS=Bos taurus OX=9913 GN=SUMF2 PE=2 SV=1 CANONICAL=Q58CP2-1" }, "locus": { "chromosome": "25", "start_pos": 27754218, "end_pos": 27738682, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101257.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101257.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074839.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074839.1" } ] } }, { "isoform_ac": "A0AAA9S5G4-1", "url": "https://www.uniprot.org/uniprotkb/Q58CP2/entry#A0AAA9S5G4-1", "sequence": { "sequence": "MGISLSPLLTVLSLLSGRWLELGNGQTVNMVQLPGGRFQMGTDSPDGRDGEGPVREVTVKPFAIDIFPVTNKDFREFVREKKYRTEAEVFGWSFVFEDLVSDELRNKATQRMQSLLWWLPVERAFWRQPAGPGSGIREKLEFPVVHVSWNDARAYCAWRGKRLPTEEEWEFAARGGLKGQVYPWGNKFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPPQNDYGLYDLVGNVWEWTASQYQAADQDMRVLRGASWIDTADGSANHRARVTTRAEGRGLELNPGSRKLELGAPSLRALRRRGPWVAGDSLGVSG", "length": 315, "header": "tr|A0AAA9S5G4-1|SUMF2_BOVIN Computationally mapped isoform of Inactive C-alpha-formylglycine-generating enzyme 2 OS=Bos taurus OX=9913 GN=SUMF2 PE=2 SV=1 CANONICAL=Q58CP2-1" }, "locus": { "chromosome": "25", "start_pos": 27754218, "end_pos": 27738682, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127482.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127482.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080446.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080446.1" } ] } }, { "isoform_ac": "Q58CP2-1", "url": "https://www.uniprot.org/uniprotkb/Q58CP2/entry#Q58CP2-1", "sequence": { "sequence": "MGISLSPLLTVLSLLSGRWLELGNGQTVNMVQLPGGRFQMGTDSPDGRDGEGPVREVTVKPFAIDIFPVTNKDFREFVREKKYRTEAEVFGWSFVFEDLVSDELRNKATQRMQSLLWWLPVERAFWRQPAGPGSGIREKLEFPVVHVSWNDARAYCAWRGKRLPTEEEWEFAARGGLKGQVYPWGNKFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPPQNDYGLYDLVGNVWEWTASQYQAADQDMRVLRGASWIDTADGSANHRARVTTRMGNTPDSASDNLGFRCASGAGRPPGEL", "length": 301, "header": "sp|Q58CP2-1|SUMF2_BOVIN Isoform 1 of Inactive C-alpha-formylglycine-generating enzyme 2 OS=Bos taurus OX=9913 GN=SUMF2 PE=2 SV=1 CANONICAL=Q58CP2-1" }, "locus": { "chromosome": "25", "start_pos": 27748605, "end_pos": 27738682, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010773.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010773.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010773.4", "url": "https://www.ensembl.org/id/ENSBTAP00000010773.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 191, "start_aa": "Asn", "end_pos": 191, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn191", "evidence": [ { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2#ptm_processing" }, { "id": "PRU00498", "database": "PROSITE-ProRule", "url": "https://prosite.expasy.org/rule/PRU00498" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CP2", "url": "https://www.uniprot.org/uniprotkb/Q58CP2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:509497", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509497", "resource": "KEGG Pathway" }, { "id": "R-BTA-1663150", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1663150", "resource": "Reactome", "description": "The activation of arylsulfatases" }, { "id": "R-BTA-9840310", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9840310", "resource": "Reactome", "description": "Glycosphingolipid catabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AED9-1", "protein_name": "Chaperonin containing TCP1 subunit 6A", "gene_name": "SUMF2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAVKALNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLQEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIVAEGFEIAKEKALEVLEQVKVTKEMDRETLIDVAKTSLRTKVHTELADILTEAVVDSVLAVRKPGEPIDLHMVEIMEMKHKSETDTTLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVSAGFFYKSAEEREKLVKAERKFIEDRVSKIIDLKRRVCGDSDKGFIVINQKGIDPFSLDALAKEGIVALRRAKRRNMERLTLACGGTAMNSVEDLTPDCLGHAGLVYEYTLGEEKYTFIEKCDNPRSVTLLIRGPNKHTLTQIKDAVRDGLRAVKNAIEDVSILLLCLVGCVIPGAGALEVAVANALVKHKPNVKGRAQLGVQAFADALLIIPKVLAQNSGYDPQETLVKVQAEHAESGQLTGVDLNTGEPMVAAAAGIWDNYNVKKQLLHSCTVIASNILLVDEIMRAGMSSLKG", "length": 539 }, "evidence": [ { "id": "Q58CP2", "url": "https://omabrowser.org/oma/group/Q58CP2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RIU4-1", "protein_name": "Inactive C-alpha-formylglycine-generating enzyme 2", "gene_name": "SUMF2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGPLLSPLLTLLSLLSGPWLELGNGQTTGMVQLPGGRFQMGTNSPDGRDGEGPVREVTVKPFAIDIFPVTNKDFRDFVREKKYRTEAEAFGWSFVFEDLVPNELRSKATHQMQSLLWWLPVERAFWRQPAGPGSGIRERLEFPVVHVSWNDARAYCAWRGKRLPTEEEWEFAARGGLKGQVYPWGNQFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPPQNNYGLYDLMGNVWEWTASPYQAADQDMRVLRGASWIDTADGSANHRARVTTRMGNTPDSASDNLGFRCASSAGRPPGEL", "length": 301 }, "evidence": [ { "id": "Q58CP2", "url": "https://omabrowser.org/oma/group/Q58CP2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8BPG6-1", "protein_name": "Inactive C-alpha-formylglycine-generating enzyme 2", "gene_name": "Sumf2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRSEFWFPSMGSLLPPVLLLWLLSCPRLQLGHAQDPAMVHLPGGRFLMGTDAPDGRDGEGPAREVTVKPFAIDIFPVTNKDFREFVREKKYQTEAEAFGWSFVFEDFVSPELRKQENLMPAVHWWQPVPKAFWRQPAGPGSGIREKLELPVVHVSWNDAGAYCAWRGRRLPTEEEWEFAARGGLKGQVYPWGNRFQPNRTNLWQGKFPKGDKAEDGFHGLSPVNAFPPQNNYGLYDLMGNVWEWTASTYQPAGQDMRVLRGASWIDTADGSANHRARVTTRMGNTPDSASDNLGFRCASSAGRPKEDL", "length": 308 }, "evidence": [ { "id": "Q58CP2", "url": "https://omabrowser.org/oma/group/Q58CP2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NBJ7-1", "protein_name": "Inactive C-alpha-formylglycine-generating enzyme 2", "gene_name": "SUMF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARHGLPLLPLLSLLVGAWLKLGNGQATSMVQLQGGRFLMGTNSPDSRDGDGPVREATVKPFAIDIFPVTNKDFRDFVREKKYRTEAEMFGWSFVFEDFVSDELRNKATQPMKSVLWWLPVEKAFWRQPAGPGSGIRERLEHPVLHVSWNDARAYCAWRGKRLPTEEEWEFAARGGLKGQVYPWGNWFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPAQNNYGLYDLLGNVWEWTASPYQAAEQDMRVLRGASWIDTADGSANHRARVTTRMGNTPDSASDNLGFRCAADAGRPPGEL", "length": 301 }, "evidence": [ { "id": "Q58CP2", "url": "https://omabrowser.org/oma/group/Q58CP2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q58CP2", "url": "https://www.uniprot.org/uniprotkb/Q58CP2" } ], "pmid": "" }, { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "Q58CP2", "url": "https://www.uniprot.org/uniprotkb/Q58CP2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q58CP2", "url": "https://www.uniprot.org/uniprotkb/Q58CP2" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q58CP2", "url": "https://www.uniprot.org/uniprotkb/Q58CP2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 191, "end_pos": 193, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CP2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 301, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CP2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CP2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Non-canonical ER retention motif", "eco_id": "ECO_0000250", "start_pos": 298, "end_pos": 301, "start_aa": "Pro", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2#function" }, { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2" } ], "binding_site_uniprot": 194, "amino_acid": "Asn", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 194, "end_pos": 194, "start_aa": "Asn", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2#function" }, { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2" } ], "binding_site_uniprot": 195, "amino_acid": "Leu", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 195, "end_pos": 195, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2#function" }, { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2" } ], "binding_site_uniprot": 208, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 208, "end_pos": 208, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2#function" }, { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2" } ], "binding_site_uniprot": 210, "amino_acid": "Phe", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 210, "end_pos": 210, "start_aa": "Phe", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2#function" }, { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2" } ], "binding_site_uniprot": 229, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 229, "end_pos": 229, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2#function" }, { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2" } ], "binding_site_uniprot": 232, "amino_acid": "Gly", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 232, "end_pos": 232, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2#function" }, { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2" } ], "binding_site_uniprot": 234, "amino_acid": "Val", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 234, "end_pos": 234, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2#function" }, { "id": "Q58CP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CP2" } ], "binding_site_uniprot": 236, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 236, "end_pos": 236, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 191 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 191, "end_pos": 193 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q59I47-1", "uniprot_ac": "Q59I47", "uniprot_id": "SMUG1_BOVIN", "mass": { "chemical_mass": 30040.0, "monoisotopic_mass": 30040.0 }, "refseq": { "ac": "NP_001014958", "name": "single-strand selective monofunctional uracil DNA glycosylase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014958" }, "gene_names": [ { "name": "SMUG1", "type": "recommended", "evidence": [ { "id": "Q59I47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59I47" } ] }, { "name": "SMUG1", "type": "synonym", "evidence": [ { "id": "NP_001014958", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014958" } ] } ], "protein_names": [ { "name": "Single-strand selective monofunctional uracil DNA glycosylase", "type": "recommended", "evidence": [ { "id": "Q59I47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59I47/entry#names_and_taxonomy" } ] }, { "name": "3.2.2.-", "type": "synonym", "evidence": [ { "id": "Q59I47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q59I47/entry#names_and_taxonomy" } ] }, { "name": "single-strand selective monofunctional uracil DNA glycosylase", "type": "synonym", "evidence": [ { "id": "NP_001014958", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014958" } ] } ], "function": [ { "annotation": "Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration.", "evidence": [ { "database": "UniProtKB", "id": "Q59I47", "url": "https://www.uniprot.org/uniprotkb/Q59I47#function" }, { "database": "UniProtKB", "id": "Q53HV7", "url": "https://www.uniprot.org/uniprotkb/Q53HV7#function" }, { "database": "UniProtKB", "id": "A0A3Q1M4X6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X6#function" }, { "database": "UniProtKB", "id": "ARBA00060140", "url": "https://www.uniprot.org/uniprotkb/ARBA00060140#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q59I47", "url": "https://www.uniprot.org/uniprotkb/Q59I47" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMUG1", "url": "https://www.uniprot.org/uniprotkb/Q59I47", "locus": { "chromosome": "5", "start_pos": 25862906, "end_pos": 25855745, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021974", "url": "https://www.ensembl.org/id/ENSBTAG00000021974" } ] } } ], "crossref": [ { "id": "Q59I47", "url": "https://alphafold.ebi.ac.uk/entry/Q59I47", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021974", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021974", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19374", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19374", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539771", "url": "https://www.ncbi.nlm.nih.gov/gene/539771", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036895", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036895", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039134", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039134", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539771", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539771", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VANYCPL", "url": "https://omabrowser.org/oma/group/VANYCPL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q59I47", "url": "https://www.orthodb.org/?gene=Q59I47", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13235:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13235:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03167", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03167", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-110329", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110329", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-110357", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110357", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001014958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014958", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4X6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4X6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q59I47", "url": "https://www.uniprot.org/uniprotkb/Q59I47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q59I47-1", "url": "https://www.uniprot.org/uniprotkb/Q59I47-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVPQPFPSGPHLQPAGALMEPQPSPRSLAEGFLQEELRLNDELRQLQFSELVGIVYNPVEYAWEPHRSYVTRYCQGPKQVLFLGMNPGPFGMAQTGVPFGEVSVVRDWLGLGGPVRTPPQEHPKRPVLGLECPQSEVSGARFWGFFRNLCGQPEVFFRHCFVHNLCPLLLLAPSGRNITPAELPAKQREQLLGVCDAALCRQVQLLGVRLVVGVGRVAEQRARRALASLMPEVQVEGLLHPSPRSPQANKGWEAVAKERLNELGLLPLLTS", "length": 272, "header": "sp|Q59I47-1|SMUG1_BOVIN Isoform 1 of Single-strand selective monofunctional uracil DNA glycosylase OS=Bos taurus OX=9913 GN=SMUG1 PE=2 SV=1 CANONICAL=Q59I47-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M4X6-1", "url": "https://www.uniprot.org/uniprotkb/Q59I47/entry#A0A3Q1M4X6-1", "sequence": { "sequence": "MPIITLKIRPCHSSVYPWPCCLQDGSLKIKGDSGMAVPQPFPSGPHLQPAGALMEPQPSPRSLAEGFLQEELRLNDELRQLQFSELVGIVYNPVEYAWEPHRSYVTRYCQGPKQVLFLGMNPGPFGMAQTGVPFGEVSVVRDWLGLGGPVRTPPQEHPKRPVLGLECPQSEVSGARFWGFFRNLCGQPEVFFRHCFVHNLCPLLLLAPSGRNITPAELPAKQREQLLGVCDAALCRQVQLLGVRLVVGVGRVAEQRARRALASLMPEVQVEGLLHPSPRSPQANKGWEAVAKERLNELGLLPLLTS", "length": 306, "header": "tr|A0A3Q1M4X6-1|SMUG1_BOVIN Computationally mapped isoform of Single-strand selective monofunctional uracil DNA glycosylase OS=Bos taurus OX=9913 GN=SMUG1 PE=2 SV=2 CANONICAL=Q59I47-1" }, "locus": { "chromosome": "5", "start_pos": 25861131, "end_pos": 25856487, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082361.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082361.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063312.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063312.2" } ] } }, { "isoform_ac": "A0AAA9SL91-1", "url": "https://www.uniprot.org/uniprotkb/Q59I47/entry#A0AAA9SL91-1", "sequence": { "sequence": "MAVPQPFPSGPHLQPAGALMEPQPSPRSLAEGFLQEELRLNDELRQLQFSELVGIVYNPVEYAWEPHRSYVTRYCQGPKQVLFLGMNPGPFGMAQTGVPFGEVSVVRDWLGLGGPVRTPPQEHPKRPVLGLECPQSEANKGWEAVAKERLNELGLLPLLTS", "length": 161, "header": "tr|A0AAA9SL91-1|SMUG1_BOVIN Computationally mapped isoform of Single-strand selective monofunctional uracil DNA glycosylase OS=Bos taurus OX=9913 GN=SMUG1 PE=2 SV=2 CANONICAL=Q59I47-1" }, "locus": { "chromosome": "5", "start_pos": 25861131, "end_pos": 25859318, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120744.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120744.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086031.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086031.2" } ] } }, { "isoform_ac": "Q59I47-1", "url": "https://www.uniprot.org/uniprotkb/Q59I47/entry#Q59I47-1", "sequence": { "sequence": "MAVPQPFPSGPHLQPAGALMEPQPSPRSLAEGFLQEELRLNDELRQLQFSELVGIVYNPVEYAWEPHRSYVTRYCQGPKQVLFLGMNPGPFGMAQTGVPFGEVSVVRDWLGLGGPVRTPPQEHPKRPVLGLECPQSEVSGARFWGFFRNLCGQPEVFFRHCFVHNLCPLLLLAPSGRNITPAELPAKQREQLLGVCDAALCRQVQLLGVRLVVGVGRVAEQRARRALASLMPEVQVEGLLHPSPRSPQANKGWEAVAKERLNELGLLPLLTS", "length": 272, "header": "sp|Q59I47-1|SMUG1_BOVIN Isoform 1 of Single-strand selective monofunctional uracil DNA glycosylase OS=Bos taurus OX=9913 GN=SMUG1 PE=2 SV=1 CANONICAL=Q59I47-1" }, "locus": { "chromosome": "5", "start_pos": 25861131, "end_pos": 25859318, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029297.7", "url": "https://www.ensembl.org/id/ENSBTAT00000029297.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029297.4", "url": "https://www.ensembl.org/id/ENSBTAP00000029297.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 180, "start_aa": "Thr", "end_pos": 180, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr180", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Linkage analysis reveals two independent loci for ocular disorders in a local Japanese Black cattle population.", "journal": "Anim. Genet.", "date": "2005", "authors": "Ihara N, Fujita T, Shiga K, Itoh M, Watanabe T, Sugimoto Y", "evidence": [ { "database": "UniProtKB", "id": "Q59I47", "url": "https://www.uniprot.org/uniprotkb/Q59I47" } ], "reference": [ { "type": "PubMed", "id": "15771722", "url": "https://glygen.org/publication/PubMed/15771722" } ] } ], "pathway": [ { "id": "bta:539771", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539771", "resource": "KEGG Pathway" }, { "id": "R-BTA-110329", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110329", "resource": "Reactome", "description": "Cleavage of the damaged pyrimidine" }, { "id": "R-BTA-110357", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110357", "resource": "Reactome", "description": "Displacement of DNA glycosylase by APEX1" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1W4T3-1", "protein_name": "Single-strand-selective monofunctional uracil-DNA glycosylase 1", "gene_name": "SMUG1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAVPQAFPLGPLHEPAGALMEPQPSPRSLAEGFLEEELRLNGELKQLQFSEPVGLIYNPVEYAWEPHRSYVTRYCQGPKQVLFLGMNPGPFGMAQTGVPFGEVSMVRDWLGIGGSVLTPPQEHPKRPVLGLECPQSEVSGARFWGFFRNLCGQPEVFFRHCFVHNLCPLLLLAPSGRNLTPAELPAKQREQLLGVCDAALCRQVQLLGVRLVVGVGRVAEQRARRALAGLMPEVQVEGLLHPSPRSPQANKGWEAVAKERLNELGLLPLLTK", "length": 272 }, "evidence": [ { "id": "Q59I47", "url": "https://omabrowser.org/oma/group/Q59I47/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7F7L8-1", "protein_name": "Single-strand selective monofunctional uracil DNA glycosylase isoform X1", "gene_name": "Smug1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MELQAIQGDSGMAVSQAFLPGPTHEPTGPLMEPLPCTRSLAEGFLEEELRLNAELRQLQFPEPVGVIYNPVDYAWEPHSNYVTRYCQGPKEVLFLGMNPGPFGMAQTGVPFGEVNVVRDWLGVGGSVRTPPQEHPKRPVLGLECTQSEVSGARFWGLFRALCGQPHVFFRHCFVHNLCPLLFLAPSGRNLTPAELPAKQREQLLMICDAALCRQVQLLGVRLVVGVGRLAEQRARRALAGLSPEVQVEGLLHPSPRSPQANKGWEAAARERLQELGLLPLLTSECPARSSTP", "length": 292 }, "evidence": [ { "id": "Q59I47", "url": "https://omabrowser.org/oma/group/Q59I47/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q53HV7-1", "protein_name": "Single-strand selective monofunctional uracil DNA glycosylase", "gene_name": "SMUG1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPQAFLLGSIHEPAGALMEPQPCPGSLAESFLEEELRLNAELSQLQFSEPVGIIYNPVEYAWEPHRNYVTRYCQGPKEVLFLGMNPGPFGMAQTGVPFGEVSMVRDWLGIVGPVLTPPQEHPKRPVLGLECPQSEVSGARFWGFFRNLCGQPEVFFHHCFVHNLCPLLFLAPSGRNLTPAELPAKQREQLLGICDAALCRQVQLLGVRLVVGVGRLAEQRARRALAGLMPEVQVEGLLHPSPRNPQANKGWEAVAKERLNELGLLPLLLK", "length": 270 }, "evidence": [ { "id": "Q59I47", "url": "https://omabrowser.org/oma/group/Q59I47/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6P5C5-1", "protein_name": "Single-strand selective monofunctional uracil DNA glycosylase", "gene_name": "Smug1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAASQTFPLGPTHEPASALMEPLPCTRSLAEGFLEEELRLNAELSQLQFPEPVGVIYNPVDYAWEPHRNYVTRYCQGPKEVLFLGMNPGPFGMAQTGVPFGEVNVVRDWLGVGGPVLTPPQEHPKRPVLGLECPQSEVSGARFWGFFRTLCGQPQVFFRHCFVHNLCPLLFLAPSGRNLTPAELPAKQREQLLSICDAALCRQVQLLGVRLVVGVGRLAEQRARRALAGLTPEVQVEGLLHPSPRSAQANKGWEAAARERLQELGLLPLLTDEGSARPT", "length": 279 }, "evidence": [ { "id": "Q59I47", "url": "https://omabrowser.org/oma/group/Q59I47/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q811Q1-1", "protein_name": "Single-strand selective monofunctional uracil-DNA glycosylase", "gene_name": "Smug1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAVSQTFPPGPAHEPASALMEPCARSLAEGFLEEELRLNAELSQLQFPEPVGVIYNPVDYAWEPHRNYVTRYCQGPKEVLFLGMNPGPFGMAQTGVPFGEVNVVRDWLGIGGSVLSPPQEHPKRPVLGLECPQSEVSGARFWGFFRTLCGQPQVFFRHCFVHNLCPLLFLAPSGRNLTPADLPAKHREQLLSICDAALCRQVQLLGVRLVVGVGRLAEQRARRALAGLTPEVQVEGLLHPSPRSPQANKGWETAARERLQELGLLPLLTDEGSVRPTP", "length": 278 }, "evidence": [ { "id": "Q59I47", "url": "https://omabrowser.org/oma/group/Q59I47/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9VEM1-1", "protein_name": "3.2.2.27", "gene_name": "Smug", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLKRKLNQQKCNLEIGEPTKTSARQGSTSEFFDKPLWLKFYETEVKLNEALEKLNPPESTPFIYNPIVYASQLHCDYLRRYMDGPKKLVFVGMNPGPNGMAQTGIPFGNVRTVKLLMQLAGSVDQPPVVHPKRPVAGLDCRIEEPSGVRLWELFLRLAGSMQTFSQQCFVHNFCPLAFFGADGRNITPSEIRGAYKNQLGDLCLHTLEEQLKLLQPDVIVAVGEYVHSALKRSGYAKSNCVSVLRLPHPSPRSTNNTNWPEKAQAFLEEHNLIRFMRNEA", "length": 280 }, "evidence": [ { "id": "Q59I47", "url": "https://omabrowser.org/oma/group/Q59I47/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q59I47", "url": "https://www.uniprot.org/uniprotkb/Q59I47" } ], "pmid": "" }, { "name": "DNA N-glycosylase activity", "id": "GO:0019104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019104", "evidence": [ { "database": "UniProtKB", "id": "Q59I47", "url": "https://www.uniprot.org/uniprotkb/Q59I47" } ], "pmid": "" }, { "name": "uracil DNA N-glycosylase activity", "id": "GO:0004844", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004844", "evidence": [ { "database": "UniProtKB", "id": "Q59I47", "url": "https://www.uniprot.org/uniprotkb/Q59I47" } ], "pmid": "" }, { "name": "single-strand selective uracil DNA N-glycosylase activity", "id": "GO:0017065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017065", "evidence": [ { "database": "UniProtKB", "id": "Q59I47", "url": "https://www.uniprot.org/uniprotkb/Q59I47" } ], "pmid": "" }, { "name": "oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity", "id": "GO:0000703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000703", "evidence": [ { "database": "UniProtKB", "id": "Q59I47", "url": "https://www.uniprot.org/uniprotkb/Q59I47" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q59I47", "url": "https://www.uniprot.org/uniprotkb/Q59I47" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q59I47", "url": "https://www.uniprot.org/uniprotkb/Q59I47" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "Q59I47", "url": "https://www.uniprot.org/uniprotkb/Q59I47" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "base-excision repair", "id": "GO:0006284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006284", "evidence": [ { "database": "UniProtKB", "id": "Q59I47", "url": "https://www.uniprot.org/uniprotkb/Q59I47" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 178, "end_pos": 180, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-110221", "name": "Cleavage of uracil by SMUG1 glycosylase", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q59I47-1" ], "evidence": [ { "id": "R-BTA-110221", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110221" } ] }, { "id": "R-BTA-110351", "name": "Displacement of SMUG1 glycosylase by APEX1 at the AP site", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-50119" ], "output_participant_list": [ "R-BTA-110161" ], "enzyme_list": [ "A0AAA9SUJ2-1", "Q59I47-1" ], "evidence": [ { "id": "R-BTA-110351", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110351" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-110161", "participant_name": "SMUG1 [nucleoplasm]", "crossref": [ { "id": "XP_005206225.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAP00000029297", "database": "ENSEMBL", "url": "" }, { "id": "35039", "database": "VGNC", "url": "" }, { "id": "XP_005206226.1", "database": "RefSeq", "url": "" }, { "id": "Q59I47", "database": "UniProt", "url": "" }, { "id": "ENSBTAT00000029297", "database": "ENSEMBL", "url": "" }, { "id": "XP_015326436.1", "database": "RefSeq", "url": "" }, { "id": "NP_001014958.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAG00000021974", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-50119", "participant_name": "APEX1 [nucleoplasm]", "crossref": [ { "id": "A0A140T846", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000002745", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000003559", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000003559", "database": "ENSEMBL", "url": "" }, { "id": "NP_788782.2", "database": "RefSeq", "url": "" }, { "id": "26011", "database": "VGNC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SUJ2", "gene_name": "APEX1", "activity": [ { "ec_number": "3.1.11.2", "activity": "Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.", "evidence": [ { "id": "A0AAA9SUJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUJ2" } ] }, { "ec_number": "3.1.21.-", "activity": "", "evidence": [ { "id": "A0AAA9SUJ2", "database": "UniProtKB", "url": 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"date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9Q7-1", "uniprot_ac": "Q5E9Q7", "uniprot_id": "2ABB_BOVIN", "mass": { "chemical_mass": 51710.0, "monoisotopic_mass": 51710.0 }, "refseq": { "ac": "NP_001259014", "name": "serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259014" }, "gene_names": [ { "name": "PPP2R2B", "type": "recommended", "evidence": [ { "id": "Q5E9Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7" } ] }, { "name": "PPP2R2B", "type": "synonym", "evidence": [ { "id": "NP_001259014", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259014" } ] } ], "protein_names": [ { "name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform", "type": "recommended", "evidence": [ { "id": "Q5E9Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7/entry#names_and_taxonomy" } ] }, { "name": "BRbeta B-regulatory subunit of protein phosphatase 2A", "type": "synonym", "evidence": [ { "id": "NP_001259014", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259014" } ] }, { "name": "PP2A subunit B isoform B55-beta", "type": "synonym", "evidence": [ { "id": "Q5E9Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7/entry#names_and_taxonomy" } ] }, { "name": "PP2A subunit B isoform PR55-beta", "type": "synonym", "evidence": [ { "id": "Q5E9Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7/entry#names_and_taxonomy" } ] }, { "name": "PP2A subunit B isoform R2-beta", "type": "synonym", "evidence": [ { "id": "Q5E9Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7/entry#names_and_taxonomy" } ] }, { "name": "PP2A subunit B isoform beta", "type": "synonym", "evidence": [ { "id": "Q5E9Q7", "database": "UniProtKB", "url": 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"MEEDIDTRKINNSFLRDHSYATEADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN", "length": 443, "header": "sp|Q5E9Q7-1|2ABB_BOVIN Isoform 1 of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform OS=Bos taurus OX=9913 GN=PPP2R2B PE=2 SV=1 CANONICAL=Q5E9Q7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M5E1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7/entry#A0A3Q1M5E1-1", "sequence": { "sequence": "MNLERRQEHTICGLSSWSSRLGALTQDTLWCFSQLKGTVEIGATEADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN", "length": 465, "header": "tr|A0A3Q1M5E1-1|2ABB_BOVIN Computationally mapped isoform of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform OS=Bos taurus OX=9913 GN=PPP2R2B PE=2 SV=2 CANONICAL=Q5E9Q7-1" }, "locus": { "chromosome": "7", "start_pos": 58309531, "end_pos": 57796644, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070545.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070545.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065504.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065504.2" } ] } }, { "isoform_ac": "A0A3Q1M9B9-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7/entry#A0A3Q1M9B9-1", "sequence": { "sequence": "MIPGLGALTQDTLWCFSQLKGTVEIGATEADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN", "length": 449, "header": "tr|A0A3Q1M9B9-1|2ABB_BOVIN Computationally mapped isoform of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform OS=Bos taurus OX=9913 GN=PPP2R2B PE=2 SV=2 CANONICAL=Q5E9Q7-1" }, "locus": { "chromosome": "7", "start_pos": 58305568, "end_pos": 57796644, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083608.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083608.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065034.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065034.2" } ] } }, { "isoform_ac": "A0A3Q1MH72-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7/entry#A0A3Q1MH72-1", "sequence": { "sequence": "MNYPDEITYGNKADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN", "length": 432, "header": "tr|A0A3Q1MH72-1|2ABB_BOVIN Computationally mapped isoform of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform OS=Bos taurus OX=9913 GN=PPP2R2B PE=2 SV=1 CANONICAL=Q5E9Q7-1" }, "locus": { "chromosome": "7", "start_pos": 58088099, "end_pos": 57796644, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067103.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067103.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068406.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068406.1" } ] } }, { "isoform_ac": "A0A3Q1MJU7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7/entry#A0A3Q1MJU7-1", "sequence": { "sequence": "MEEDIDTRKINNSFLRDHSYATEEHFRLASFSLPSSLLHWSKPPPSRTWTVVMTYQQDYLSPCLYPLSALSDIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN", "length": 490, "header": "tr|A0A3Q1MJU7-1|2ABB_BOVIN Computationally mapped isoform of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform OS=Bos taurus OX=9913 GN=PPP2R2B PE=2 SV=2 CANONICAL=Q5E9Q7-1" }, "locus": { "chromosome": "7", "start_pos": 58109749, "end_pos": 57796644, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074552.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074552.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071664.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071664.2" } ] } }, { "isoform_ac": "A0A3Q1N515-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7/entry#A0A3Q1N515-1", "sequence": { "sequence": "MKSPMETKKGKAVCGFHNAESLVELGWPTMPDIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN", "length": 450, "header": "tr|A0A3Q1N515-1|2ABB_BOVIN Computationally mapped isoform of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform OS=Bos taurus OX=9913 GN=PPP2R2B PE=2 SV=2 CANONICAL=Q5E9Q7-1" }, "locus": { "chromosome": "7", "start_pos": 58088086, "end_pos": 57796644, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079481.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079481.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065068.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065068.2" } ] } }, { "isoform_ac": "A0AAA9S0F3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7/entry#A0AAA9S0F3-1", "sequence": { "sequence": "MVLQPAERHCGDWSHRRLGPWCSPTGSPAPLSCETGCGEGTWILVCRLLVPTQVSLLSMEEDIDTRKINNSFLRDHSYATEADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN", "length": 501, "header": "tr|A0AAA9S0F3-1|2ABB_BOVIN Computationally mapped isoform of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform OS=Bos taurus OX=9913 GN=PPP2R2B PE=2 SV=1 CANONICAL=Q5E9Q7-1" }, "locus": { "chromosome": "7", "start_pos": 58305412, "end_pos": 57796644, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100343.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100343.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078444.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078444.1" } ] } }, { "isoform_ac": "A0AAA9SBE3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7/entry#A0AAA9SBE3-1", "sequence": { "sequence": "MKCFSRYLPYIFRPPNTILSSSCHTEADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN", "length": 446, "header": "tr|A0AAA9SBE3-1|2ABB_BOVIN Computationally mapped isoform of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform OS=Bos taurus OX=9913 GN=PPP2R2B PE=2 SV=1 CANONICAL=Q5E9Q7-1" }, "locus": { "chromosome": "7", "start_pos": 58269201, "end_pos": 57796644, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111445.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111445.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081215.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081215.1" } ] } }, { "isoform_ac": "A0AAA9SP76-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7/entry#A0AAA9SP76-1", "sequence": { "sequence": "MLLSLPALHLQTSEHHPLFQLPHGRLGPWCSPTGSPAPLSCETGCGEGTWILVCRLLVPTQVSLLSMEEDIDTRKINNSFLRDHSYATEADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN", "length": 509, "header": "tr|A0AAA9SP76-1|2ABB_BOVIN Computationally mapped isoform of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform OS=Bos taurus OX=9913 GN=PPP2R2B PE=2 SV=1 CANONICAL=Q5E9Q7-1" }, "locus": { "chromosome": "7", "start_pos": 58269196, "end_pos": 57796644, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104122.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104122.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088118.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088118.1" } ] } }, { "isoform_ac": "A0AAA9SQ04-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7/entry#A0AAA9SQ04-1", "sequence": { "sequence": "MVLQPAERHCGDWSHRRLLTTLGQNIRDGSQSVLCQWTRHSECKDQHADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN", "length": 467, "header": "tr|A0AAA9SQ04-1|2ABB_BOVIN Computationally mapped isoform of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform OS=Bos taurus OX=9913 GN=PPP2R2B PE=2 SV=1 CANONICAL=Q5E9Q7-1" }, "locus": { "chromosome": "7", "start_pos": 58305412, "end_pos": 57796644, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130949.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130949.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085007.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085007.1" } ] } }, { "isoform_ac": "Q5E9Q7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7/entry#Q5E9Q7-1", "sequence": { "sequence": "MEEDIDTRKINNSFLRDHSYATEADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN", "length": 443, "header": "sp|Q5E9Q7-1|2ABB_BOVIN Isoform 1 of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform OS=Bos taurus OX=9913 GN=PPP2R2B PE=2 SV=1 CANONICAL=Q5E9Q7-1" }, "locus": { "chromosome": "7", "start_pos": 58109749, "end_pos": 57796644, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002427.4", "url": "https://www.ensembl.org/id/ENSBTAT00000002427.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002427.2", "url": "https://www.ensembl.org/id/ENSBTAP00000002427.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 275, "end_pos": 275, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q7", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7" } ], "site_lbl": "Ser275" }, { "start_pos": 295, "end_pos": 295, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q7", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7" } ], "site_lbl": "Tyr295" }, { "start_pos": 298, "end_pos": 298, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q7", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7" } ], "site_lbl": "Thr298" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q7", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "The protein phosphatase PP2A/B\u03b1 binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies.", "journal": "The Journal of biological chemistry", "date": "2012-04-27", "authors": "Sontag Jean-Marie, Nunbhakdi-Craig Viyada, White Charles L, Halpain Shelley, Sontag Estelle", "evidence": [ { "database": "RefSeq", "id": "NP_001259014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259014" } ], "reference": [ { "type": "PubMed", "id": "22403409", "url": "https://glygen.org/publication/PubMed/22403409" } ] }, { "title": "Activation of transient receptor potential vanilloid 1 decreases endothelial nitric oxide synthase phosphorylation at Thr497 by protein phosphatase 2B-dependent dephosphorylation of protein kinase C.", "journal": "Acta physiologica (Oxford, England)", "date": "2013-10", "authors": "Ching L-C, Zhao J-F, Su K-H, Shyue S-K, Hsu C-P, Lu T-M, Lin S-J, Lee T-S", "evidence": [ { "database": "RefSeq", "id": "NP_001259014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259014" } ], "reference": [ { "type": "PubMed", "id": "24028645", "url": "https://glygen.org/publication/PubMed/24028645" } ] } ], "pathway": [ { "id": "bta:509290", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509290", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PC44-1", "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B", "gene_name": "PPP2R2B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEEDVETRKINSSFLRDHSYATEADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQPHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEDGRLRDPSMITSLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRTSALCDRHAKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAVLKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN", "length": 443 }, "evidence": [ { "id": "Q5E9Q7", "url": "https://omabrowser.org/oma/group/Q5E9Q7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A480P307-1", "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B", "gene_name": "PPP2R2B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKCFSRYLPYIFRPPNTILSSSCHTEADIISAVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN", "length": 446 }, "evidence": [ { "id": "Q5E9Q7", "url": "https://omabrowser.org/oma/group/Q5E9Q7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P36877-1", "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform", "gene_name": "Ppp2r2b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEEDIDTRKINNSFLRDHSYATEADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTAKVWDLNMENRPVETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN", "length": 443 }, "evidence": [ { "id": "Q5E9Q7", "url": "https://omabrowser.org/oma/group/Q5E9Q7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q00005-1", "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform", "gene_name": "PPP2R2B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"MNGGDDAATSGPPPSLEWRFSQVFGERTAGEEVQEVDIISAIEFDKSGDHLATGDRGGRVVLFERTDTKDHGGSRKDLEQTDYPVRHPEFRYKTEFQSHEPEFDYLKSLEIEEKINKIRWCQPANGALFLLSTNDKTIKYWKVQEKKIKKISEMNIDPSESSNIPPQLVTNGLPADKGHDYLSKDFSFPPGGIPSLRLPVVVTSQETNLVARCRRVYAHAHDYHINSISNSSDGETFISADDLRVNLWNLEISNQSFNIVDVKPTNMEDLTEVITSAEFHPIHCNMLAYSSSKGSIRLIDMRQSALCDSHTKLFEEPEAPGSRSFFTEIIASISDIKFSKDGRYILSRDYMTLKLWDINMDSGPVASYQVHEHLRPRLCDLYENDSIFDKFECCLSGDGLRVATGSYSNLFRVFGASQGSTEAATLEASKNPMRRQIQTPARPSRSIGSMTRVVRRGSESPGTEANGNAYDFTTKLLHMAWHPTENSIACAAANSLYMYYA", "length": 501 }, "evidence": [ { "id": "Q5E9Q7", "url": "https://omabrowser.org/oma/group/Q5E9Q7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q6ZWR4-1", "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform", "gene_name": "Ppp2r2b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEDIDTRKINNSFLRDHSYATEADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN", "length": 443 }, "evidence": [ { "id": "Q5E9Q7", "url": "https://omabrowser.org/oma/group/Q5E9Q7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q7", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q7", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q7", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7" } ], "pmid": "" }, { "name": "protein phosphatase type 2A complex", "id": "GO:0000159", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000159", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q7", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein phosphatase regulator activity", "id": "GO:0019888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019888", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q7", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 11, "end_pos": 13, "annotation": "n_glycosylation_sequon" }, { "start_pos": 205, "end_pos": 207, "annotation": "n_glycosylation_sequon" }, { "start_pos": 273, "end_pos": 275, "annotation": "n_glycosylation_sequon" }, { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" }, { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9Q7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 443, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9Q7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9Q7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 275, 295, 298 ], "sequon_annotation_sites": [ { "start_pos": 11, "end_pos": 13 }, { "start_pos": 205, "end_pos": 207 }, { "start_pos": 273, "end_pos": 275 }, { "start_pos": 33, "end_pos": 35 }, { "start_pos": 347, "end_pos": 349 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": 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} ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EAB0-1", "uniprot_ac": "Q5EAB0", "uniprot_id": "MPZL2_BOVIN", "mass": { "chemical_mass": 24456.0, "monoisotopic_mass": 24456.0 }, "refseq": { "ac": "NP_001015673", "name": "myelin protein zero-like protein 2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015673" }, "gene_names": [ { "name": "MPZL2", "type": "recommended", "evidence": [ { "id": "Q5EAB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB0" } ] }, { "name": "EVA1", "type": "synonym", "evidence": [ { "id": "NP_001015673", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015673" }, { "id": "Q5EAB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB0" } ] }, { "name": "MPZL2", "type": "synonym", "evidence": [ { "id": "NP_001015673", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015673" } ] } ], "protein_names": [ { "name": "Myelin protein zero-like protein 2", "type": "recommended", "evidence": [ { "id": "Q5EAB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB0/entry#names_and_taxonomy" } ] }, { "name": "Epithelial V-like antigen 1", "type": "synonym", "evidence": [ { "id": "Q5EAB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB0/entry#names_and_taxonomy" } ] }, { "name": "epithelial V-like antigen 1", "type": "synonym", "evidence": [ { "id": "NP_001015673", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015673" } ] }, { "name": "myelin protein zero-like protein 2 precursor", "type": "synonym", "evidence": [ { "id": "NP_001015673", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015673" } ] }, { "name": "myelin protein zero-like protein 2", "type": "synonym", "evidence": [ { "id": "NP_001015673", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015673" } ] } ], "function": [ { "annotation": "Mediates homophilic cell-cell adhesion.", "evidence": [ { "database": "UniProtKB", "id": "Q5EAB0", "url": "https://www.uniprot.org/uniprotkb/Q5EAB0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EAB0", "url": "https://www.uniprot.org/uniprotkb/Q5EAB0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MPZL2", "url": "https://www.uniprot.org/uniprotkb/Q5EAB0", "locus": { "chromosome": "15", "start_pos": 28942899, "end_pos": 28953445, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033510", "url": "https://www.ensembl.org/id/ENSBTAG00000033510" } ] } } ], "crossref": [ { "id": "Q5EAB0", "url": "https://alphafold.ebi.ac.uk/entry/Q5EAB0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033510", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033510", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05880", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05880", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540423", "url": "https://www.ncbi.nlm.nih.gov/gene/540423", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000920", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000920", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540423", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540423", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FHEQPYP", "url": "https://omabrowser.org/oma/group/FHEQPYP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M9H5", "url": "https://www.orthodb.org/?gene=A0A3Q1M9H5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5EAB0", "url": "https://www.orthodb.org/?gene=Q5EAB0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13869", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13869", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13869:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13869:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015673", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9H5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9H5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9H5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9H5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EAB0", "url": "https://www.uniprot.org/uniprotkb/Q5EAB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EAB0-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAB0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYGKSPTRAVLFLLGLQLTALWPTAAVEIYTPRVLEAVNGTDVRLKCTFSSFAPVGDALTVTWNFRPRDGGPEQFVFYYHVDPFKPMSGRFKDRVAWDGNPERYDVSILLWKLQFDDNGTYTCQVKNPPDVDGLIGEIQLSVVQTVRFSEIHFLALAIGSACALMVIIVIVVVLFQHFRKKRRAERAHRVVEIKSKEEEKLNQEKKASVSLEYTD", "length": 215, "header": "sp|Q5EAB0-1|MPZL2_BOVIN Isoform 1 of Myelin protein zero-like protein 2 OS=Bos taurus OX=9913 GN=MPZL2 PE=2 SV=1 CANONICAL=Q5EAB0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M9H5-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAB0/entry#A0A3Q1M9H5-1", "sequence": { "sequence": "ELGHLTSVGCPAAAAAKSLQLCPTLCDPIDSSPPGPAVPGILQARTPYSDLYFGSVSRNSLKTHLLLTLHCLFSIAALWPTAAVEIYTPRVLEAVNGTDVRLKCTFSSFAPVGDALTVTWNFRPRDGGPEQFVFYYHVDPFKPMSGRFKDRVAWDGNPERYDVSILLWKLQFDDNGTYTCQVKNPPDVDGLIGEIQLSVVQTVRFSEIHFLALAIGSACALMVIIVIVVVLFQHFRKKRRAERAHRVVEIKSKEEEKLNQEKKASVSLEYTD", "length": 272, "header": "tr|A0A3Q1M9H5-1|MPZL2_BOVIN Computationally mapped isoform of Myelin protein zero-like protein 2 OS=Bos taurus OX=9913 GN=MPZL2 PE=2 SV=2 CANONICAL=Q5EAB0-1" }, "locus": { "chromosome": "15", "start_pos": 28952286, "end_pos": 28945715, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077328.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077328.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067214.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067214.2" } ] } }, { "isoform_ac": "Q5EAB0-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAB0/entry#Q5EAB0-1", "sequence": { "sequence": "MYGKSPTRAVLFLLGLQLTALWPTAAVEIYTPRVLEAVNGTDVRLKCTFSSFAPVGDALTVTWNFRPRDGGPEQFVFYYHVDPFKPMSGRFKDRVAWDGNPERYDVSILLWKLQFDDNGTYTCQVKNPPDVDGLIGEIQLSVVQTVRFSEIHFLALAIGSACALMVIIVIVVVLFQHFRKKRRAERAHRVVEIKSKEEEKLNQEKKASVSLEYTD", "length": 215, "header": "sp|Q5EAB0-1|MPZL2_BOVIN Isoform 1 of Myelin protein zero-like protein 2 OS=Bos taurus OX=9913 GN=MPZL2 PE=2 SV=1 CANONICAL=Q5EAB0-1" }, "locus": { "chromosome": "15", "start_pos": 28953204, "end_pos": 28945715, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001633.3", "url": "https://www.ensembl.org/id/ENSBTAT00000001633.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001633.1", "url": "https://www.ensembl.org/id/ENSBTAP00000001633.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 118, "start_aa": "Asn", "end_pos": 118, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn118", "evidence": [ { "id": "Q5EAB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB0#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 39, "start_aa": "Asn", "end_pos": 39, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn39", "evidence": [ { "id": "Q5EAB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB0#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EAB0", "url": "https://www.uniprot.org/uniprotkb/Q5EAB0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:540423", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540423", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4AAE2-1", "protein_name": "Myelin protein zero-like 2", "gene_name": "Mpzl2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYGKSLARVLPFLLSLQLTVFYPTTAVEIYTSGALEAVNGTDIRLKCTFSSFAPVGDALTVTWNFRPRDGGREQFVFYYHMDPFRPMSGRFKDRVVWDGNPERYDVSIMLWKLQFDDNGTYTCQVKNPPDVDGLIGTIRLSVVHTVPFSEIYFLAVAIGSACALMIIIVIVVVLFQHFRKKRWAERADKSEGTKSKEEEKLNQGTKVSVYVEDTD", "length": 215 }, "evidence": [ { "id": "Q5EAB0", "url": "https://omabrowser.org/oma/group/Q5EAB0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O60487-1", "protein_name": "Myelin protein zero-like protein 2", "gene_name": "MPZL2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYGKSSTRAVLLLLGIQLTALWPIAAVEIYTSRVLEAVNGTDARLKCTFSSFAPVGDALTVTWNFRPLDGGPEQFVFYYHIDPFQPMSGRFKDRVSWDGNPERYDASILLWKLQFDDNGTYTCQVKNPPDVDGVIGEIRLSVVHTVRFSEIHFLALAIGSACALMIIIVIVVVLFQHYRKKRWAERAHKVVEIKSKEEERLNQEKKVSVYLEDTD", "length": 215 }, "evidence": [ { "id": "Q5EAB0", "url": "https://omabrowser.org/oma/group/Q5EAB0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O70255-1", "protein_name": "Myelin protein zero-like protein 2", "gene_name": "Mpzl2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYGKSPALVLPLLLSLQLTALCPTEAVEIYTSGALEAVNGTDVRLKCTFSSFAPVGDALTVTWNFRPRDGGREQFVFYYHMDPFRPMSGRFKDRVVWDGNPERYDVSILLWKLQFDDNGTYTCQVKNPPDVDGLVGTIRLSVVHTVPFSEIYFLAVAIGSACALMIIVVIVVVLFQHFRKKRWADRADKAEGTKSKEEEKLNQGNKVSVFVEDTD", "length": 215 }, "evidence": [ { "id": "Q5EAB0", "url": "https://omabrowser.org/oma/group/Q5EAB0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q5EAB0", "url": "https://www.uniprot.org/uniprotkb/Q5EAB0" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q5EAB0", "url": "https://www.uniprot.org/uniprotkb/Q5EAB0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "Q5EAB0", "url": "https://www.uniprot.org/uniprotkb/Q5EAB0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 118, "end_pos": 120, "annotation": "n_glycosylation_sequon" }, { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EAB0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 215, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EAB0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EAB0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 39, 118 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 118, "end_pos": 120 }, { "start_pos": 39, "end_pos": 41 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EAC5-1", "uniprot_ac": "Q5EAC5", "uniprot_id": "ZN410_BOVIN", "mass": { "chemical_mass": 50860.0, "monoisotopic_mass": 50860.0 }, "refseq": { "ac": "NP_001019662", "name": "zinc finger protein 410 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019662" }, "gene_names": [ { "name": "ZNF410", "type": "recommended", "evidence": [ { "id": "Q5EAC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ] }, { "name": "C14orf44", "type": "synonym", "evidence": [ { "id": "NP_001019662", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019662" } ] }, { "name": "FAM161B", "type": "synonym", "evidence": [ { "id": "NP_001019662", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019662" } ] }, { "name": "ZNF410", "type": "synonym", "evidence": [ { "id": "NP_001019662", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019662" } ] } ], "protein_names": [ { "name": "Zinc finger protein 410", "type": "recommended", "evidence": [ { "id": "Q5EAC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5/entry#names_and_taxonomy" } ] }, { "name": "clones 23667 and 23775 zinc finger protein", "type": "synonym", "evidence": [ { "id": "NP_001019662", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019662" } ] }, { "name": "family with sequence similarity 161, member B", "type": "synonym", "evidence": [ { "id": "NP_001019662", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019662" } ] }, { "name": "zinc finger protein 410 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001019662", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019662" } ] } ], "function": [ { "annotation": "Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells. Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells. May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence. May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose. However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4.", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC5", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5#function" }, { "database": "UniProtKB", "id": "Q86VK4", "url": "https://www.uniprot.org/uniprotkb/Q86VK4#function" }, { "database": "UniProtKB", "id": "A0A3Q1MBE0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBE0#function" }, { "database": "UniProtKB", "id": "ARBA00055956", "url": "https://www.uniprot.org/uniprotkb/ARBA00055956#function" }, { "database": "UniProtKB", "id": "A0AAA9RXU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXU0#function" }, { "database": "UniProtKB", "id": "A0AAA9T9K3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K3#function" }, { "database": "UniProtKB", "id": "F6QI02", "url": "https://www.uniprot.org/uniprotkb/F6QI02#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EAC5", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF410", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5", "locus": { "chromosome": "10", "start_pos": 85320048, "end_pos": 85277929, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020327", "url": "https://www.ensembl.org/id/ENSBTAG00000020327" } ] } } ], "crossref": [ { "id": "Q5EAC5", "url": "https://alphafold.ebi.ac.uk/entry/Q5EAC5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020327", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020327", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507530", "url": "https://www.ncbi.nlm.nih.gov/gene/507530", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051061", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051061", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507530", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507530", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "XNDRSFI", "url": "https://omabrowser.org/oma/group/XNDRSFI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MBE0", "url": "https://www.orthodb.org/?gene=A0A3Q1MBE0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MVS0", "url": "https://www.orthodb.org/?gene=A0A3Q1MVS0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5EAC5", "url": "https://www.orthodb.org/?gene=Q5EAC5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14003", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14003", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14003:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14003:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46179", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46179", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46179:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46179:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001019662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019662", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBE0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBE0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVS0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVS0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVS0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVS0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXU0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXU0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9K3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9K3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QI02", "url": "https://www.uniprot.org/uniprotkb/F6QI02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QI02-1", "url": "https://www.uniprot.org/uniprotkb/F6QI02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EAC5", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EAC5-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSDELESKPELLVQFVQNTSIPLGQGLVESEAKDITCLSLLPVTEASECSRLMLPDDTPNHTNSSKEVPSSAVLRSLQVNVGPDGEETRAQTVQKSPEFLSTPESPSLLQDLQPSDSTSFILLNLTRAGLGSSAEHLVFVQDEADDSGNDFLSSESTDSSIPWFLRVQELAHDSLIAATRAQLAKNAKTSSNGENVHLGSGDGQPKDSGPLPQMEKKLKCTVEGCDRTFVWPAHFKYHLKTHRNDRSFICPAAGCGKSFYVLQRLKVHMRTHNGEKPFVCPESNCGKQFTTAGNLKNHLRIHTGEKPFLCEAQGCGRSFAEYSSLRKHLVVHSGEKPHQCQVCGKTFSQSGSRNVHMRKHHLQMGAAGSQEQEPAAEPLMGSSLLEEASVTSKNLVSMNSQPSLGGESLNLPNTNSILGVDDEVLAEGSPRPLSSVPDVTHHLVTMQSGRQSYELLNQGDLTERRT", "length": 467, "header": "sp|Q5EAC5-1|ZN410_BOVIN Isoform 1 of Zinc finger protein 410 OS=Bos taurus OX=9913 GN=ZNF410 PE=2 SV=1 CANONICAL=Q5EAC5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MBE0-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5/entry#A0A3Q1MBE0-1", "sequence": { "sequence": "MLSDELESKPELLVQFVQNTSIPLGQGLVESEAKDITCLSLLPVTEASECSRLMLPDDTPNHTNSSKEVPSSAVLRSLQVNVGPDGEETRAQTVQKSPEFLSTPESPSLLQDLQPSDSTSFILLNLTRAGLGSSAEHLVFVQDEADDSGNDFLSSESTDSSIPWFLRVQELAHDSLIAATRAQLAKNAKTSSNGENVHLGSGDGQPKDSGPLPQMEKKLKCTVEGCDRTFVWPAHFKYHLKTHRNDRSFICPAAGCGKSFYVLQRLKVHMRTHNGEKPFVCPESNCGKQFTTAGNLKNHLRIHTGEKPFLCEAQGCGRSFAEYSSLRKHLVVHSGEKPHQCQVCGKTFSQSGSRNVHMRKHHLQMGAAGSQEQEPAEVLAEGSPRPLSSVPDVTHHLVTMQSGRQSYEVSVLTAVNPQELLNQGDLTERRT", "length": 431, "header": "tr|A0A3Q1MBE0-1|ZN410_BOVIN Computationally mapped isoform of Zinc finger protein 410 OS=Bos taurus OX=9913 GN=ZNF410 PE=2 SV=2 CANONICAL=Q5EAC5-1" }, "locus": { "chromosome": "10", "start_pos": 85319298, "end_pos": 85293905, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068595.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068595.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071388.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071388.2" } ] } }, { "isoform_ac": "A0A3Q1MVS0-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5/entry#A0A3Q1MVS0-1", "sequence": { "sequence": "MLSDELESKPELLVQFVQNTSIPLGQGLVESEAKDITCLSLLPVTEASECSRLMLPDDTPNHTNSSKEVPSSAVLRSLQVNVGPDGEETRAQTVQKSPEFLSTPESPSLLQDLQPSDSTSFILLNLTRAGLGSSAEHLVFVQDEADDSGNDFLSSESTDSSIPWFLRVQELAHDSLIAATRAQLAKNAKTSSNGENVHLGSGDGQPKDSGPLPQMEKKLKCTVEGCDRTFVWPAHFKYHLKTHRNDRSFICPAAGCGKSFYVLQRLKVHMRTHNGEKPFVCPESNCGEKPFLCEAQGCGRSFAEYSSLRKHLVVHSGEKPHQCQVCGKTFSQSGSRNVHMRKHHLQMGAAGSQEQEPAAEPLMGSSLLEEASVTSKNLVSMNSQPSLGGESLNLPNTNSILGVDDEVLAEGSPRPLSSVPDVTHHLVTMQSGRQSYEVSVLTAVNPQELLNQGDLTERRT", "length": 460, "header": "tr|A0A3Q1MVS0-1|ZN410_BOVIN Computationally mapped isoform of Zinc finger protein 410 OS=Bos taurus OX=9913 GN=ZNF410 PE=2 SV=3 CANONICAL=Q5EAC5-1" }, "locus": { "chromosome": "10", "start_pos": 85319298, "end_pos": 85293905, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078718.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078718.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059241.3", "url": "https://www.ensembl.org/id/ENSBTAP00000059241.3" } ] } }, { "isoform_ac": "A0AAA9RXU0-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5/entry#A0AAA9RXU0-1", "sequence": { "sequence": "MLSDELESKPELLVQFVQNTSIPLGQGLVESEAKDITCLSLLPVTEASECSRLMLPGLGSSAEHLVFVQDEADDSGNDFLSSESTDSSIPWFLRVQELAHDSLIAATRAQLAKNAKTSSNGENVHLGSGDGQPKDSGPLPQMEKKLKCTVEGCDRTFVWPAHFKYHLKTHRNDRSFICPAAGCGKSFYVLQRLKVHMRTHNGEKPFVCPESNCGKQFTTAGNLKNHLRIHTGEKPFLCEAQGCGRSFAEYSSLRKHLVVHSGEKPHQCQVCGKTFSQSGSRNVHMRKHHLQMGAAGSQEQEPAAEPLMGSSLLEEASVTSKNLVSMNSQPSLGGESLNLPNTNSILGVDDEVLAEGSPRPLSSVPDVTHHLVTMQSGRQSYEVSVLTAVNPQELLNQGDLTERRT", "length": 405, "header": "tr|A0AAA9RXU0-1|ZN410_BOVIN Computationally mapped isoform of Zinc finger protein 410 OS=Bos taurus OX=9913 GN=ZNF410 PE=2 SV=1 CANONICAL=Q5EAC5-1" }, "locus": { "chromosome": "10", "start_pos": 85319298, "end_pos": 85293905, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135996.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135996.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076038.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076038.1" } ] } }, { "isoform_ac": "A0AAA9T9K3-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5/entry#A0AAA9T9K3-1", "sequence": { "sequence": "YLSMKTDTLLVQFVQNTSIPLGQGLVESEAKDITCLSLLPVTEASECSRLMLPDDTPNHTNSSKEVPSSAVLRSLQVNVGPDGEETRAQTVQKSPEFLSTPESPSLLQDLQPSDSTSFILLNLTRAGLGSSAEHLVFVQDEADDSGNDFLSSESTDSSIPWFLRVQELAHDSLIAATRAQLAKNAKTSSNGENVHLGSGDGQPKDSGPLPQMEKKLKCTVEGCDRTFVWPAHFKYHLKTHRNDRSFICPAAGCGKSFYVLQRLKVHMRTHNGEKPFVCPESNCGKQFTTAGNLKNHLRIHTGEKPFLCEAQGCGRSFAEYSSLRKHLVVHSGEKPHQCQVCGKTFSQSGSRNVHMRKHHLQMGAAGSQEQEPAAEPLMGSSLLEEASVTSKNLVSMNSQPSLGGESLNLPNTNSILGVDDEVLAEGSPRPLSSVPDVTHHLVTMQSGRQSYEAEPTEHMGMCPLVC", "length": 466, "header": "tr|A0AAA9T9K3-1|ZN410_BOVIN Computationally mapped isoform of Zinc finger protein 410 OS=Bos taurus OX=9913 GN=ZNF410 PE=2 SV=2 CANONICAL=Q5EAC5-1" }, "locus": { "chromosome": "10", "start_pos": 85315006, "end_pos": 85295146, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096987.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096987.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093545.2", "url": "https://www.ensembl.org/id/ENSBTAP00000093545.2" } ] } }, { "isoform_ac": "F6QI02-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5/entry#F6QI02-1", "sequence": { "sequence": "MLSDELESKPELLVQFVQNTSIPLGQGLVESEAKDITCLSLLPVTEASECSRLMLPDDTPNHTNSSKEVPSSAVLRSLQVNVGPDGEETRAQTVQKSPEFLSTPESPSLLQDLQPSDSTSFILLNLTRAGLGSSAEHLVFVQDEADDSGNDFLSSESTDSSIPWFLRVQELAHDSLIAATRAQLAKNAKTSSNGENVHLGSGDGQPKDSGPLPQMEKKLKCTVEGCDRTFVWPAHFKYHLKTHRNDRSFICPAAGCGKSFYVLQRLKVHMRTHNGEKPFVCPESNCGKQFTTAGNLKNHLRIHTGEKPFLCEAQGCGRSFAEYSSLRKHLVVHSGEKPHQCQVCGKTFSQSGSRNVHMRKHHLQMGAAGSQEQEPAAEPLMGSSLLEEASVTSKNLVSMNSQPSLGGESLNLPNTNSILGVDDEVLAEGSPRPLSSVPDVTHHLVTMQSGRQSYEVSVLTAVNPQEDILLP", "length": 471, "header": "tr|F6QI02-1|F6QI02_BOVIN Computationally mapped isoform of Zinc finger protein 410 OS=Bos taurus OX=9913 GN=ZNF410 PE=4 SV=1 CANONICAL=Q5EAC5-1" }, "locus": { "chromosome": "10", "start_pos": 85319046, "end_pos": 85293905, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043166.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043166.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040756.2", "url": "https://www.ensembl.org/id/ENSBTAP00000040756.2" } ] } }, { "isoform_ac": "Q5EAC5-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5/entry#Q5EAC5-1", "sequence": { "sequence": "MLSDELESKPELLVQFVQNTSIPLGQGLVESEAKDITCLSLLPVTEASECSRLMLPDDTPNHTNSSKEVPSSAVLRSLQVNVGPDGEETRAQTVQKSPEFLSTPESPSLLQDLQPSDSTSFILLNLTRAGLGSSAEHLVFVQDEADDSGNDFLSSESTDSSIPWFLRVQELAHDSLIAATRAQLAKNAKTSSNGENVHLGSGDGQPKDSGPLPQMEKKLKCTVEGCDRTFVWPAHFKYHLKTHRNDRSFICPAAGCGKSFYVLQRLKVHMRTHNGEKPFVCPESNCGKQFTTAGNLKNHLRIHTGEKPFLCEAQGCGRSFAEYSSLRKHLVVHSGEKPHQCQVCGKTFSQSGSRNVHMRKHHLQMGAAGSQEQEPAAEPLMGSSLLEEASVTSKNLVSMNSQPSLGGESLNLPNTNSILGVDDEVLAEGSPRPLSSVPDVTHHLVTMQSGRQSYELLNQGDLTERRT", "length": 467, "header": "sp|Q5EAC5-1|ZN410_BOVIN Isoform 1 of Zinc finger protein 410 OS=Bos taurus OX=9913 GN=ZNF410 PE=2 SV=1 CANONICAL=Q5EAC5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC5", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:507530", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507530", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC5", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC5", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC5", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "pmid": "" }, { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC5", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC5", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC5", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC5", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC5", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC5", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC5", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC5", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC5", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC5", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC5", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" }, { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" }, { "start_pos": 64, "end_pos": 66, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EAC5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 467, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EAC5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EAC5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q5EAC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5#function" }, { "id": "Q5EAC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "binding_site_uniprot": 221, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "structural", "eco_id": "ECO_0000250", "start_pos": 221, "end_pos": 221, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5EAC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5#function" }, { "id": "Q5EAC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "binding_site_uniprot": 226, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "structural", "eco_id": "ECO_0000250", "start_pos": 226, "end_pos": 226, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5EAC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5#function" }, { "id": "Q5EAC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "binding_site_uniprot": 239, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "structural", "eco_id": "ECO_0000250", "start_pos": 239, "end_pos": 239, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5EAC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5#function" }, { "id": "Q5EAC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "binding_site_uniprot": 243, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "structural", "eco_id": "ECO_0000250", "start_pos": 243, "end_pos": 243, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5EAC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5#function" }, { "id": "Q5EAC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "binding_site_uniprot": 251, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "structural", "eco_id": "ECO_0000250", "start_pos": 251, "end_pos": 251, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5EAC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5#function" }, { "id": "Q5EAC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC5" } ], "binding_site_uniprot": 256, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "structural", "eco_id": "ECO_0000250", "start_pos": 256, "end_pos": 256, 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"database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504536", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504536", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AHYFNDE", "url": "https://omabrowser.org/oma/group/AHYFNDE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MBF4", "url": "https://www.orthodb.org/?gene=A0A3Q1MBF4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q56JZ7", "url": "https://www.orthodb.org/?gene=Q56JZ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46259", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46259", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46259:SF1", "url": 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"Protein" ] }, { "id": "A0AAA9T759", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T759", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T759-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T759-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JZ7", "url": "https://www.uniprot.org/uniprotkb/Q56JZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JZ7-1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGGLAPSKSTVYVSNLPFSLTNNDLYRIFSKYGKVVKVTIMKDKDTRRSKGVAFILFLDKDSAQNCTRAINNKQLFGRVIKASIAIDNGRAAEFIRRRNYFDKSKCYECGESGHLSYACPKNMLGEREPPKKKEKKKKKKIPEPEEEIEEVEESEDEGEDPALDSLSQAIAFQQAKIEEEQKKWKPSSGGPSTSDDSRRPRIKKSTYFSDEEELSD", "length": 217, "header": "sp|Q56JZ7-1|ZCRB1_BOVIN Isoform 1 of Zinc finger CCHC-type and RNA-binding motif-containing protein 1 OS=Bos taurus OX=9913 GN=ZCRB1 PE=2 SV=1 CANONICAL=Q56JZ7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MBF4-1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ7/entry#A0A3Q1MBF4-1", "sequence": { "sequence": "MTYDEQGPTGLGMGEGRGERNLFICFIYCCLIFNWLFVYALRVTIMKDKDTRRSKGVAFILFLDKDSAQNCTRAINNKQLFGRVIKASIAIDNGRAAEFIRRRNYFDKSKCYECGESGHLSYACPKNMLGEREPPKKKEKKKKKKIPEPEEEIEEVEESEDEGEDPALDSLSQAIAFQQAKIEEEQKKWKPSSGGPSTSDDSRRPRIKKSTYFSDEEELSD", "length": 221, "header": "tr|A0A3Q1MBF4-1|ZCRB1_BOVIN Computationally mapped isoform of Zinc finger CCHC-type and RNA-binding motif-containing protein 1 OS=Bos taurus OX=9913 GN=ZCRB1 PE=2 SV=2 CANONICAL=Q56JZ7-1" }, "locus": { "chromosome": "5", "start_pos": 38372040, "end_pos": 38366782, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069057.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069057.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065993.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065993.2" } ] } }, { "isoform_ac": "A0AAA9T759-1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ7/entry#A0AAA9T759-1", "sequence": { "sequence": "MSGGLAPSKSTVYVSNLPFSLTNNDLYRIFSKYGKVVKVTIMKDKDTRRSKGVAFILFLDKDSAQNCTRAINNKQLFGRVIKASIAIDNGRAAEFIRRRNYFDKSKCYECGESGHLSYACPKNMLGEREPPKKKEKKKKKKIPEPEEEIKPKLKKNKKNGNPVQEVLQHQMIQDAQG", "length": 177, "header": "tr|A0AAA9T759-1|ZCRB1_BOVIN Computationally mapped isoform of Zinc finger CCHC-type and RNA-binding motif-containing protein 1 OS=Bos taurus OX=9913 GN=ZCRB1 PE=2 SV=1 CANONICAL=Q56JZ7-1" }, "locus": { "chromosome": "5", "start_pos": 38372040, "end_pos": 38356414, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099149.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099149.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092437.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092437.1" } ] } }, { "isoform_ac": "Q56JZ7-1", "url": "https://www.uniprot.org/uniprotkb/Q56JZ7/entry#Q56JZ7-1", "sequence": { "sequence": "MSGGLAPSKSTVYVSNLPFSLTNNDLYRIFSKYGKVVKVTIMKDKDTRRSKGVAFILFLDKDSAQNCTRAINNKQLFGRVIKASIAIDNGRAAEFIRRRNYFDKSKCYECGESGHLSYACPKNMLGEREPPKKKEKKKKKKIPEPEEEIEEVEESEDEGEDPALDSLSQAIAFQQAKIEEEQKKWKPSSGGPSTSDDSRRPRIKKSTYFSDEEELSD", "length": 217, "header": "sp|Q56JZ7-1|ZCRB1_BOVIN Isoform 1 of Zinc finger CCHC-type and RNA-binding motif-containing protein 1 OS=Bos taurus OX=9913 GN=ZCRB1 PE=2 SV=1 CANONICAL=Q56JZ7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 155, "end_pos": 155, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ7", "url": "https://www.uniprot.org/uniprotkb/Q56JZ7" } ], "site_lbl": "Ser155" }, { "start_pos": 210, "end_pos": 210, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ7", "url": "https://www.uniprot.org/uniprotkb/Q56JZ7" } ], "site_lbl": "Ser210" }, { "start_pos": 216, "end_pos": 216, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ7", "url": "https://www.uniprot.org/uniprotkb/Q56JZ7" } ], "site_lbl": "Ser216" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504536", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504536", "resource": "KEGG Pathway" }, { "id": "R-BTA-72165", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72165", "resource": "Reactome", "description": "mRNA Splicing - Minor Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1TVT7-1", "protein_name": "Zinc finger CCHC-type and RNA-binding motif-containing protein 1", "gene_name": "ZCRB1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGGLAPSKSTVYVSNLPFSLTNNDLYRIFSKYGKVVKVTIMKDKDTRKSKGVAFILFLDKDSAQNCTRAINNKQLFGRVIKASIAIDNGRAAEFIRRRNYFDKSKCYECGESGHLSYACPKNMLGEREPPKKKEKKKKKKIPEPEEEIEEVEESDDEGEDPALDSLSQAIAFQQAKIEEEQRKWKPSSGGPSTSDDSRRPRIKKSTYFSDEEELSD", "length": 217 }, "evidence": [ { "id": "Q56JZ7", "url": "https://omabrowser.org/oma/group/Q56JZ7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2N728-1", "protein_name": "Zinc finger CCHC-type and RNA-binding motif-containing protein 1", "gene_name": "Zcrb1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSGGLAPSKSTVYVSNLPFSLTNNDLYRIFSKYGKVVKVTIMKDKDTRRSKGVAFILFLDKDSALNCTRAINNKQLFGRVIKASIAIDNGRAAEFIRRRNYFDKSKCYECGESGHLSYACPKNMLGEREPPKKKEKKKKKKVPEPEEVEEVEVSEEEGEDPALDSLSQAIAFQQAKIEEEQNKWRPSPGGPSTSDDSRRPRIKKSAYFSDEEELSD", "length": 216 }, "evidence": [ { "id": "Q56JZ7", "url": "https://omabrowser.org/oma/group/Q56JZ7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E1BTK3-1", "protein_name": "Zinc finger CCHC-type and RNA-binding motif-containing protein 1", "gene_name": "ZCRB1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGGLAPSKSTVYVSNLPFALTNNDLYRIFSKYGKVVKVTIMKDKDTRKSKGVAFILFLDKESAQNCSRALNNKQLFGRVIKASIAIDNGRAAEFIRRRNYFDKSKCYECGEAGHLSYACPKNMLGEREPPKKKEKKKRKKVVEPEEIEEEEESEEEGEDPALDSLSQAIAVQQAKIEEEQQRWTQTAGESSVSDDSKRPRIKKSAYFSDEEELSD", "length": 216 }, "evidence": [ { "id": "Q56JZ7", "url": "https://omabrowser.org/oma/group/Q56JZ7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q499V6-1", "protein_name": "Zinc finger CCHC-type and RNA-binding motif-containing protein 1", "gene_name": "Zcrb1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGGLAPSKSTVYVSNLPFSLTNNDLYRIFSKYGKVVKVTIMKDKDTRKSKGVAFILFLDKDSALNCTRAINNKQLFGRVIKASIAIDNGRAAEFIRRRNYFDKSKCYECGESGHLSYACPKNMLGEREPPKKKEKKKKKKVPEPEEEIEEVEVSEEEGEDPALDSLSQAIAFQQAKIEEEQNKWRPSTGGPSTSDDSRRPRIKKSAYFSDEEELSD", "length": 217 }, "evidence": [ { "id": "Q56JZ7", "url": "https://omabrowser.org/oma/group/Q56JZ7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5SP50-1", "protein_name": "Zinc finger CCHC-type and RNA-binding motif-containing protein 1", "gene_name": "zcrb1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSGGLAPSKSTVYVSNIPFSLTNSDMHKLCSKYGKVVKVTIVKDKHTRMSKGVAFVLFLDRESAYNCSRSLNNKQLFGRMVKASIAIDNGRAAEFIRKRNYTDKSKCYECGEEGHLSYACPKNLLGEREPPPKKEKKKKKKVQQPEEVEPEDSEEEGEDPALDSLSQAIAFQQARIEEEEKRRKQAAEDASQASTSEDTHKPRIKKSAYFSDEEELSD", "length": 218 }, "evidence": [ { "id": "Q56JZ7", "url": "https://omabrowser.org/oma/group/Q56JZ7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8TBF4-1", "protein_name": "Zinc finger CCHC-type and RNA-binding motif-containing protein 1", "gene_name": "ZCRB1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGGLAPSKSTVYVSNLPFSLTNNDLYRIFSKYGKVVKVTIMKDKDTRKSKGVAFILFLDKDSAQNCTRAINNKQLFGRVIKASIAIDNGRAAEFIRRRNYFDKSKCYECGESGHLSYACPKNMLGEREPPKKKEKKKKKKAPEPEEEIEEVEESEDEGEDPALDSLSQAIAFQQAKIEEEQKKWKPSSGVPSTSDDSRRPRIKKSTYFSDEEELSD", "length": 217 }, "evidence": [ { "id": "Q56JZ7", "url": "https://omabrowser.org/oma/group/Q56JZ7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CZ96-1", "protein_name": "Zinc finger CCHC-type and RNA-binding motif-containing protein 1", "gene_name": "Zcrb1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGGLAPSKSTVYVSNLPFSLTNNDLYRIFSKYGKVVKVTIMKDKDTRKSKGVAFILFLDKDSALNCTRAINNKQLFGRVIKASIAIDNGRAAEFIRRRNYFDKSKCYECGESGHLSYACPKNMLGEREPPKKKEKKKKRKLPEPEEEIEEVEVSEEEGEDPALDSLSQAIAFQQAKIEEEQSKWRPNPGGPSTSDDSRRPRIKKSAYFSDEEELSD", "length": 217 }, "evidence": [ { "id": "Q56JZ7", "url": "https://omabrowser.org/oma/group/Q56JZ7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ7", "url": "https://www.uniprot.org/uniprotkb/Q56JZ7" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ7", "url": "https://www.uniprot.org/uniprotkb/Q56JZ7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ7", "url": "https://www.uniprot.org/uniprotkb/Q56JZ7" } ], "pmid": "" }, { "name": "U12-type spliceosomal complex", "id": "GO:0005689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005689", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ7", "url": "https://www.uniprot.org/uniprotkb/Q56JZ7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "Q56JZ7", "url": "https://www.uniprot.org/uniprotkb/Q56JZ7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q56JZ7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 217, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q56JZ7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q56JZ7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q56JZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JZ7" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000255", "start_pos": 10, "end_pos": 88, "start_aa": "Ser", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 155, 210, 216 ], "sequon_annotation_sites": [ { "start_pos": 66, "end_pos": 68 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q7YS80-1", "uniprot_ac": "Q7YS80", "uniprot_id": "MYF6_BOVIN", "mass": { "chemical_mass": 26976.0, "monoisotopic_mass": 26976.0 }, "refseq": { "ac": "NP_861527", "name": "myogenic factor 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861527" }, "gene_names": [ { "name": "MYF6", "type": "recommended", "evidence": [ { "id": "Q7YS80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS80" } ] }, { "name": "MRF4", "type": "synonym", "evidence": [ { "id": "NP_861527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861527" }, { "id": "Q7YS80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS80" } ] }, { "name": "MYF6", "type": "synonym", "evidence": [ { "id": "NP_861527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861527" } ] } ], "protein_names": [ { "name": "Myogenic factor 6", "type": "recommended", "evidence": [ { "id": "Q7YS80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS80/entry#names_and_taxonomy" } ] }, { "name": "Muscle-specific regulatory factor 4", "type": "synonym", "evidence": [ { "id": "Q7YS80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS80/entry#names_and_taxonomy" } ] }, { "name": "Myf-6", "type": "synonym", "evidence": [ { "id": "Q7YS80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YS80/entry#names_and_taxonomy" } ] }, { "name": "muscle-specific regulatory factor 4", "type": "synonym", "evidence": [ { "id": "NP_861527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861527" } ] }, { "name": "myf-6", "type": "synonym", "evidence": [ { "id": "NP_861527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861527" } ] }, { "name": "myogenic factor 6 (herculin)", "type": "synonym", "evidence": [ { "id": "NP_861527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861527" } ] }, { "name": "myogenic factor 6, transcription activator", "type": "synonym", "evidence": [ { "id": "NP_861527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861527" } ] }, { "name": "myogenic factor 6", "type": "synonym", "evidence": [ { "id": "NP_861527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861527" } ] } ], "function": [ { "annotation": "Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q7YS80", "url": "https://www.uniprot.org/uniprotkb/Q7YS80#function" } ] }, { "annotation": "MRF4 and H-FABP genes are associated with growth traits in Qinchuan cattle and related hybrids [MRF4]", "evidence": [ { "database": "RefSeq", "id": "NP_861527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861527" }, { "database": "PubMed", "id": "20582633", "url": "https://glygen.org/publication/PubMed/20582633" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q7YS80", "url": "https://www.uniprot.org/uniprotkb/Q7YS80" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYF6", "url": "https://www.uniprot.org/uniprotkb/Q7YS80", "locus": { "chromosome": "5", 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"database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039704", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039704", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281336", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281336", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SPCQDQI", "url": "https://omabrowser.org/oma/group/SPCQDQI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MBU6", "url": "https://www.orthodb.org/?gene=A0A3Q1MBU6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q7YS80", "url": "https://www.orthodb.org/?gene=Q7YS80", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11534", "url": 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"https://www.uniprot.org/uniprotkb/Q3ZBS3/entry#names_and_taxonomy" } ] }, { "name": "Golgi adaptor HA1/AP1 adaptin sigma-1B subunit", "type": "synonym", "evidence": [ { "id": "Q3ZBS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS3/entry#names_and_taxonomy" } ] }, { "name": "Sigma 1B subunit of AP-1 clathrin", "type": "synonym", "evidence": [ { "id": "Q3ZBS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS3/entry#names_and_taxonomy" } ] }, { "name": "Sigma-adaptin 1B", "type": "synonym", "evidence": [ { "id": "Q3ZBS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS3/entry#names_and_taxonomy" } ] }, { "name": "Sigma1B-adaptin", "type": "synonym", "evidence": [ { "id": "Q3ZBS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS3/entry#names_and_taxonomy" } ] }, { "name": "adapter-related protein complex 1 sigma-1B subunit", "type": "synonym", "evidence": [ { "id": "NP_001035681", 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] }, { "id": "bta:616331", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616331", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MBU7", "url": "https://www.orthodb.org/?gene=A0A3Q1MBU7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MLF5", "url": "https://www.orthodb.org/?gene=A0A3Q1MLF5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBS3", "url": "https://www.orthodb.org/?gene=Q3ZBS3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11753", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11753", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01217", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01217", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2132295", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "database": 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127670367, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068520.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068520.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071566.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071566.2" } ] } }, { "isoform_ac": "A0A3Q1MLF5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS3/entry#A0A3Q1MLF5-1", "sequence": { "sequence": "MQFMLLFSRQGKLRLQKWYVPLSDKEKKKITRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQESKHLEGQTTLRWGK", "length": 156, "header": "tr|A0A3Q1MLF5-1|AP1S2_BOVIN Computationally mapped isoform of AP-1 complex subunit sigma-2 OS=Bos taurus OX=9913 GN=AP1S2 PE=2 SV=2 CANONICAL=Q3ZBS3-1" }, "locus": { "chromosome": "X", "start_pos": 127677522, "end_pos": 127670367, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081704.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081704.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071846.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071846.2" } ] } }, { "isoform_ac": "A0AAA9STM1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS3/entry#A0AAA9STM1-1", "sequence": { "sequence": "MQFMLLFSRQGKLRLQKWYVPLSDKEKKKITRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQESQNEEWGGLSEDIL", "length": 156, "header": "tr|A0AAA9STM1-1|AP1S2_BOVIN Computationally mapped isoform of AP-1 complex subunit sigma-2 OS=Bos taurus OX=9913 GN=AP1S2 PE=2 SV=2 CANONICAL=Q3ZBS3-1" }, "locus": { "chromosome": "X", "start_pos": 127681364, "end_pos": 127670367, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089448.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089448.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086435.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086435.2" } ] } }, { "isoform_ac": "A0AAA9TIN4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS3/entry#A0AAA9TIN4-1", "sequence": { "sequence": "MQFMLLFSRQGKLRLQKWYVPLSDKEKKKITRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQEPRHEYFNVPVY", "length": 153, "header": "tr|A0AAA9TIN4-1|AP1S2_BOVIN Computationally mapped isoform of AP-1 complex subunit sigma-2 OS=Bos taurus OX=9913 GN=AP1S2 PE=2 SV=1 CANONICAL=Q3ZBS3-1" }, "locus": { "chromosome": "X", "start_pos": 127688787, "end_pos": 127670367, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112390.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112390.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096997.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096997.1" } ] } }, { "isoform_ac": "A0ABI0P3S5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS3/entry#A0ABI0P3S5-1", "sequence": { "sequence": "MQFMLLFSRQGKLRLQKWYVPLSDKEKKKITRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQEEAETPRSVLEEIGLT", "length": 157, "header": "tr|A0ABI0P3S5-1|A0ABI0P3S5_BOVIN Computationally mapped isoform of AP complex subunit sigma OS=Bos taurus OX=9913 GN=AP1S2 PE=3 SV=1 CANONICAL=Q3ZBS3-1" }, "locus": { "chromosome": "X", "start_pos": 127693755, "end_pos": 127670367, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000148302.1", "url": "https://www.ensembl.org/id/ENSBTAT00000148302.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105973.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105973.1" } ] } }, { "isoform_ac": "Q3ZBS3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS3/entry#Q3ZBS3-1", "sequence": { "sequence": "MQFMLLFSRQGKLRLQKWYVPLSDKEKKKITRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQEDAKEAETPRSVLEEIGLT", "length": 160, "header": "sp|Q3ZBS3-1|AP1S2_BOVIN Isoform 1 of AP-1 complex subunit sigma-2 OS=Bos taurus OX=9913 GN=AP1S2 PE=2 SV=1 CANONICAL=Q3ZBS3-1" }, "locus": { "chromosome": "X", "start_pos": 127693755, "end_pos": 127670367, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027212.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027212.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027212.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027212.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616331", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616331", "resource": "KEGG Pathway" }, { "id": "R-BTA-2132295", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "resource": "Reactome", "description": "MHC class II antigen presentation" }, { "id": "R-BTA-432720", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432720", "resource": "Reactome", "description": "Lysosome Vesicle Biogenesis" }, { "id": "R-BTA-432722", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432722", "resource": "Reactome", "description": "Golgi Associated Vesicle Biogenesis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "clathrin-coated pit", "id": "GO:0005905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005905", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS3" } ], "pmid": "" }, { "name": "AP-1 adaptor complex", "id": "GO:0030121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030121", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS3" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "clathrin adaptor activity", "id": "GO:0035615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035615", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBS3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 160, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBS3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBS3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q8SPX7-1", "uniprot_ac": "Q8SPX7", "uniprot_id": "CRYL1_BOVIN", "mass": { "chemical_mass": 35072.0, "monoisotopic_mass": 35072.0 }, "refseq": { "ac": "NP_776718", "name": "lambda-crystallin homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776718" }, "gene_names": [ { "name": "CRYL1", "type": "recommended", "evidence": [ { "id": "Q8SPX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7" } ] }, { "name": "CRYL1", "type": "synonym", "evidence": [ { "id": "NP_776718", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776718" } ] } ], "protein_names": [ { "name": "Lambda-crystallin homolog", "type": "recommended", "evidence": [ { "id": "Q8SPX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7/entry#names_and_taxonomy" } ] }, { "name": "1.1.1.45", "type": "synonym", "evidence": [ { "id": "Q8SPX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7/entry#names_and_taxonomy" } ] }, { "name": "Gul3DH", "type": "synonym", "evidence": [ { "id": "Q8SPX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7/entry#names_and_taxonomy" } ] }, { "name": "L-gulonate 3-dehydrogenase", "type": "synonym", "evidence": [ { "id": "NP_776718", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776718" }, { "id": "Q8SPX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7/entry#names_and_taxonomy" } ] }, { "name": "gul3DH", "type": "synonym", "evidence": [ { "id": "NP_776718", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776718" } ] }, { "name": "lambda-crystallin homolog", "type": "synonym", "evidence": [ { "id": "NP_776718", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776718" } ] } ], "function": [ { "annotation": "Catalyzes the conversion of L-gulonate to 3-dehydro-L-gulonate (By similarity). It also exhibits low dehydrogenase activity toward L-3-hydroxybutyrate (HBA) and L-threonate (By similarity). Utilizes NAD as the sole cosubstrate and shows no activity with NADP (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q8SPX7", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7#function" }, { "database": "UniProtKB", "id": "Q9Y2S2", "url": "https://www.uniprot.org/uniprotkb/Q9Y2S2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q8SPX7", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CRYL1", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7", "locus": { "chromosome": "12", "start_pos": 35985469, "end_pos": 35929014, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011726", "url": "https://www.ensembl.org/id/ENSBTAG00000011726" } ] } } ], "crossref": [ { "id": "Q8SPX7", "url": "https://alphafold.ebi.ac.uk/entry/Q8SPX7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011726", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011726", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "281725", "url": "https://www.ncbi.nlm.nih.gov/gene/281725", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006176", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006176", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006180", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006180", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008927", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008927", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022694", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022694", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281725", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281725", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RDNCLTH", "url": "https://omabrowser.org/oma/group/RDNCLTH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MBW0", "url": "https://www.orthodb.org/?gene=A0A3Q1MBW0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q8SPX7", "url": "https://www.orthodb.org/?gene=Q8SPX7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48075", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48075", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48075:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48075:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00725", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00725", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02737", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02737", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5661270", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5661270", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_776718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776718", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "12889", "url": "https://www.rhea-db.org/rhea/12889", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MBW0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBW0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYW4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYW4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVL7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVL7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1X8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1X8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1X8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1X8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8SPX7", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8SPX7-1", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASPGSSAPGGVAVVGSGLIGRSWAMLFASAGFRVKLFDIEPRQVTDALVSLRKEMKMLELSGYLKGELGAEEQLSLISGCSDLREAVEGALHVQECVPENLELKRKLFAQLDKIADDHVILSSSSSCLLPSKLFAGLAHVKQCLVAHPVNPPYYVPLVELVPHPETAPATVDRTYALMRRVGQSPVRLLREIDGFALNRLQYAVIAEAWRLVEEGVVSPGDLDLVMSDGLGLRYAFIGPLETMHLNAEGMLSYCDRYGEGMKRVLKTFGPVPEFSGATAEKVHQAMCVKVPDDAEHLAARRAWRDGCLMRLAQLKHQLPQ", "length": 321, "header": "sp|Q8SPX7-1|CRYL1_BOVIN Isoform 1 of Lambda-crystallin homolog OS=Bos taurus OX=9913 GN=CRYL1 PE=2 SV=3 CANONICAL=Q8SPX7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MBW0-1", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7/entry#A0A3Q1MBW0-1", "sequence": { "sequence": "AVKTWSCKPSGVSVTGRCVGLIGRSWAMLFASAGFRVKLFDIEPRQVTDALVSLRKEMKMLELSGYLKGELGAEEQLSLISGCSDLREAVEGALHVQECVPENLELKRKLFAQLDKIADDHVILSSSSSCLLPSKLFAGLAHVKQCLVAHPVNPPYYVPLVELVPHPETAPATVDRTYALMRRVGQSPVRLLREIDGFALNRLQYAVIAEAWRLVEEGVVSPGDLDLVMSDGLGLRYAFIGPLETMHLNAEGMLSYCDRYGEGMKRVLKTFGPVPEFSGATAEKVHQAMCVKVPDDAEHLAARRAWRDGCLMRLAQLKHQLPQ", "length": 323, "header": "tr|A0A3Q1MBW0-1|CRYL1_BOVIN Computationally mapped isoform of Lambda-crystallin homolog OS=Bos taurus OX=9913 GN=CRYL1 PE=2 SV=2 CANONICAL=Q8SPX7-1" }, "locus": { "chromosome": "12", "start_pos": 35985028, "end_pos": 35931906, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087107.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087107.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066198.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066198.2" } ] } }, { "isoform_ac": "A0AAA9SYW4-1", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7/entry#A0AAA9SYW4-1", "sequence": { "sequence": "MASPGSSAPGGVAVVGSGLIGRSWAMLFASAGFRVKLFDIEPRQVTDALVSLRKEMKMLELSGYLKGELGAEEQLSLISGCSDLREAVEGALHVQECVPENLELKRKLFAQLDKIADDHVILSSSSSCLLPSKLFAGLAHVKQCLVAHPVNPPYYVPLVELVPHPETAPATVDRTYALMRRVGQSPVRLLREIDGFALNRLQYAVIAEAWRLVEMASPSSRWPPAWHLGIVVQPLISGAEVKMAACFSSSLSCEQRVPPKVAARWGNSSGLKGSPFSGHRESGAPGPDLLRGGRCGVSG", "length": 299, "header": "tr|A0AAA9SYW4-1|CRYL1_BOVIN Computationally mapped isoform of Lambda-crystallin homolog OS=Bos taurus OX=9913 GN=CRYL1 PE=2 SV=1 CANONICAL=Q8SPX7-1" }, "locus": { "chromosome": "12", "start_pos": 35980585, "end_pos": 35929064, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113414.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113414.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089469.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089469.1" } ] } }, { "isoform_ac": "A0AAA9TVL7-1", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7/entry#A0AAA9TVL7-1", "sequence": { "sequence": "MASPGSSAPGGVAVVGSGLIGRSWAMLFASAGFRVKLFDIEPRQVTDALVSLRKEMKMLELSGYLKGELGAEEQLSLISGCSDLREAVEGALHVQECVPENLELKRKLFAQLDKIADDHVILSSSSSCLLPSKLFAGLAHVKQCLVAHPVNPPYYVPLVELVPHPETAPATVDRTYALMRRVGQSPVRLLREIDGFALNRLQYAVIAEAWRLVEEGVVSPGDLDLVMSDGLGLRYAFIGPLETMHLNAEARVPTRHKLPVSGVSAGCWPSRQWAFIRELRACCRKWSYVAAAAAKSLQSCPTLCDPVDGSPPGSPVPGILQARTLEWVAISFSKA", "length": 335, "header": "tr|A0AAA9TVL7-1|CRYL1_BOVIN Computationally mapped isoform of Lambda-crystallin homolog OS=Bos taurus OX=9913 GN=CRYL1 PE=2 SV=1 CANONICAL=Q8SPX7-1" }, "locus": { "chromosome": "12", "start_pos": 35982266, "end_pos": 35929064, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112552.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112552.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101458.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101458.1" } ] } }, { "isoform_ac": "A0AAA9TY70-1", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7/entry#A0AAA9TY70-1", "sequence": { "sequence": "MVGWHHRLDGHEFDGLIGRSWAMLFASAGFRVKLFDIEPRQVTDALVSLRKEMKMLELSGYLKGELGAEEQLSLISGCSDLREAVEGALHVQVNPPYYVPLVELVPHPETAPATVDRTYALMRRVGQSPVRLLREIDGFALNRLQYAVIAEAWRLVEEGVVSPGDLDLVMSDGLGLRYAFIGPLETMHLNAEGMLSYCDRYGEGMKRVLKTFGPVPEFSGATAEKVHQAMCVKVPDDAEHLAARRAWRDGCLMRLAQLKHQLPQ", "length": 264, "header": "tr|A0AAA9TY70-1|CRYL1_BOVIN Computationally mapped isoform of Lambda-crystallin homolog OS=Bos taurus OX=9913 GN=CRYL1 PE=2 SV=2 CANONICAL=Q8SPX7-1" }, "locus": { "chromosome": "12", "start_pos": 35985028, "end_pos": 35931110, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111998.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111998.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103302.2", "url": "https://www.ensembl.org/id/ENSBTAP00000103302.2" } ] } }, { "isoform_ac": "A0AAA9U1X8-1", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7/entry#A0AAA9U1X8-1", "sequence": { "sequence": "MVGWHHRLDGHEFDGLIGRSWAMLFASAGFRVKLFDIEPRQVTDALVSLRKEMKMLELSGYLKGELGAEEQLSLISGCSDLREAVEGALHVQECVPENLELKRKLFAQLDKIADDHVILSSSSSCLLPSKLFAGLAHVKQCLVAHPVNPPYYVPLVELVPHPETAPATVDRTYALMRRVGQSPVRLLREIDGFALNRLQYAVIAEAWRLVEEGVVSPGDLDLVMSDGLGLRYAFIGPLETMHLNAEGMLSYCDRYGEGMKRVLKTFGPVPEFSGATAEKVHQAMCVKVPDDAEHLAARRAWRDGCLMRLAQLKHQLPQ", "length": 318, "header": "tr|A0AAA9U1X8-1|CRYL1_BOVIN Computationally mapped isoform of Lambda-crystallin homolog OS=Bos taurus OX=9913 GN=CRYL1 PE=2 SV=1 CANONICAL=Q8SPX7-1" }, "locus": { "chromosome": "12", "start_pos": 35985028, "end_pos": 35931110, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114544.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114544.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103322.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103322.1" } ] } }, { "isoform_ac": "Q8SPX7-1", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7/entry#Q8SPX7-1", "sequence": { "sequence": "MASPGSSAPGGVAVVGSGLIGRSWAMLFASAGFRVKLFDIEPRQVTDALVSLRKEMKMLELSGYLKGELGAEEQLSLISGCSDLREAVEGALHVQECVPENLELKRKLFAQLDKIADDHVILSSSSSCLLPSKLFAGLAHVKQCLVAHPVNPPYYVPLVELVPHPETAPATVDRTYALMRRVGQSPVRLLREIDGFALNRLQYAVIAEAWRLVEEGVVSPGDLDLVMSDGLGLRYAFIGPLETMHLNAEGMLSYCDRYGEGMKRVLKTFGPVPEFSGATAEKVHQAMCVKVPDDAEHLAARRAWRDGCLMRLAQLKHQLPQ", "length": 321, "header": "sp|Q8SPX7-1|CRYL1_BOVIN Isoform 1 of Lambda-crystallin homolog OS=Bos taurus OX=9913 GN=CRYL1 PE=2 SV=3 CANONICAL=Q8SPX7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 3, "end_pos": 3, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8SPX7", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7" } ], "site_lbl": "Ser3" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Human CRYL1, a novel enzyme-crystallin overexpressed in liver and kidney and downregulated in 58% of liver cancer tissues from 60 Chinese patients, and four new homologs from other mammalians.", "journal": "Gene", "date": "2003", "authors": "Chen J, Yu L, Li D, Gao Q, Wang J, Huang X, Bi G, Wu H, Zhao S", "evidence": [ { "database": "UniProtKB", "id": "Q8SPX7", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7" } ], "reference": [ { "type": "PubMed", "id": "12527201", "url": "https://glygen.org/publication/PubMed/12527201" } ] } ], "pathway": [ { "id": "bta:281725", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281725", "resource": "KEGG Pathway" }, { "id": "R-BTA-5661270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5661270", "resource": "Reactome", "description": "Formation of xylulose-5-phosphate" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2ME42-1", "protein_name": "Lambda-crystallin homolog", "gene_name": "Cryl1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASPAAGGVVIVGSGLIGRSWAMLFASGGFKVKLYDIEQQQITNALENIRKEMKLLEQSGSLKGSLSAEQQLSLISGCGNLAEAVEGAMHIQECVPENLELKKKIFAQLDRIVDDRVILSSSSSCLLPSKLFTGLAHVKQCVVAHPVNPPYYVPLVELVPHPETAPATMDRTYALMKRIGQSPVRLLKEIDGFVLNRLQYAVISEAWRMMEEGIVSPNDLDLVMSDGLGMRYAFIGPLETMHLNAEGIVSYCDRYSDGMKRVLKTFGPVPEFSGATVEKVNQDICMKVPDDPEHLAARRKWRDDCLMKLAKLKHQVQPQ", "length": 319 }, "evidence": [ { "id": "Q8SPX7", "url": "https://omabrowser.org/oma/group/Q8SPX7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0XSC9-1", "protein_name": "L-gulonate 3-dehydrogenase", "gene_name": "CRYL1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MESSHVAIIGSGLIGCSWAMVFAAGGFKVKLYDIAQQQLTTALENVRKQMKELEESGFLKGTLSAEKQLALISVCTDMKAAVEGATFIQECTPENLELKKMIFSQLDLIVDDSVILSSSTSCLLPSKLFTGLKHVKQCIVSHPVNPPYFVPLVEIVPHPETDPSVTEKTYALMKKVGQSPVKLNREIEGFVLNRLQYAVISEAWRLVGEGVISPTDLDVVMSDGLGMRYAFIGPLETMHLNAEGISNYCERYREGMKLVLNTFGPVPEFSGEIEQKINQAMSEKVPAVPKHLGARREWRDDCLIGLAKLKKQMKSN", "length": 316 }, "evidence": [ { "id": "Q8SPX7", "url": "https://omabrowser.org/oma/group/Q8SPX7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q811X6-1", "protein_name": "Lambda-crystallin homolog", "gene_name": "Cryl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASPAAGGVVIIGSGLIGRSWAMLFASGGFKVKLYDIEQQQITNALESIRKEMKSLEQSGSLKGSLGAEQQLSLISGCGNLAEAVEGAMHIQECVPENLELKKKIFAQLDRIVDDQVILSSSSSCLLPSKLFTGLAHVKQCIVAHPVNPPYYVPLVELVPHPETAPATMDRTYALMKKIRQTPVRVLKEIDGFVLNRLQYAIISEAWRLVEEGIVSPNDLDLVMSDGLGMRYAFIGPLETMHLNAEGMVSYCDRYSEGMKRVLKTFGPVPEFSGDTVEKVNQDMCMKVPDDPEHLAARRHWRDDCLMQLSKLKHQMQPQ", "length": 319 }, "evidence": [ { "id": "Q8SPX7", "url": "https://omabrowser.org/oma/group/Q8SPX7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99KP3-1", "protein_name": "Lambda-crystallin homolog", "gene_name": "Cryl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASPAAGGVVIVGSGLIGRSWAMLFASGGFKVKLYDIEQQQITDALENIRKEMKSLEQSGSLKGSLSAERQLSLISGCGNLAEAVEGAVHIQECVPENLELKKKIFAQLDRIVDDRVILSSSSSCLLPSKLFSGLAHVKQCIVAHPVNPPYYVPLVELVPHPETAPATMDRTYALMKKIGQSPVRVLKEIDGFVLNRLQYAVISEAWRLVEEEIVSPSDLDLVMSDGLGMRYAFIGPLETMHLNAEGVISYCERYSEGMKHVLSTFGPVPEFSGATVERVSEDMCMKVPDDPEHLAARRQWRDDCLMKLSILKYQMQPK", "length": 319 }, "evidence": [ { "id": "Q8SPX7", "url": "https://omabrowser.org/oma/group/Q8SPX7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VXI1-1", "protein_name": "L-gulonate 3-dehydrogenase", "gene_name": "Had1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSAKNEKVGIVGSGLIGRSWSMLFASVGYQVVLYDILPEQVSTALTATQKELQDLEAKGLLRGKLTAAQQFACISGTNDLKELVKGAIFVQECIPERLDLKKALYKQLDAVVGPNTILSSSTSTFLPSLFSADLKNKANVLVSHPVNPPYYVPLVEIVPAPWTKPEWVKKTRALMEEIGQKPVTLSREIEGFALNRIQYAILNETWRLVEAGILNVKDIDSVMSNGLGPRYAFLGPLETAHLNAEGMANYFERYSNTIYAVSETMGPTPKMEGPVAVEVAKQLGEMVPLDQLAQRRNYRDNCLTQLSILKNKLNQ", "length": 315 }, "evidence": [ { "id": "Q8SPX7", "url": "https://omabrowser.org/oma/group/Q8SPX7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y2S2-1", "protein_name": "Lambda-crystallin homolog", "gene_name": "CRYL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASSAAGCVVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ", "length": 319 }, "evidence": [ { "id": "Q8SPX7", "url": "https://omabrowser.org/oma/group/Q8SPX7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "L-gulonate 3-dehydrogenase activity", "id": "GO:0050104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050104", "evidence": [ { "database": "UniProtKB", "id": "Q8SPX7", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q8SPX7", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7" } ], "pmid": "" }, { "name": "NAD+ binding", "id": "GO:0070403", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070403", "evidence": [ { "database": "UniProtKB", "id": "Q8SPX7", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "id": "GO:0016616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016616", "evidence": [ { "database": "UniProtKB", "id": "Q8SPX7", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q8SPX7", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q8SPX7", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "Q8SPX7", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7" } ], "pmid": "" }, { "name": "D-glucuronate catabolic process to D-xylulose 5-phosphate", "id": "GO:0019640", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019640", "evidence": [ { "database": "UniProtKB", "id": "Q8SPX7", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12889", "name": "", "equation": "L-gulonate + NAD(+) = 3-dehydro-L-gulonate + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8SPX7-1" ], "evidence": [ { "id": "12889", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12889" } ] }, { "id": "R-BTA-5661290", "name": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-5661262" ], "enzyme_list": [ "Q8SPX7-1" ], "evidence": [ { "id": "R-BTA-5661290", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5661290" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-5661262", "participant_name": "3-dehydro-L-gulonate [cytosol]", "crossref": [ { "id": "ZINC000100028960", "database": "ZINC", "url": "" }, { "id": "57655", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q8SPX7", "gene_name": "CRYL1", "activity": [ { "ec_number": "1.1.1.45", "activity": "L-gulonate + NAD(+) = 3-dehydro-L-gulonate + NADH + H(+).", "evidence": [ { "id": "Q8SPX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7" } ] }, { "ec_number": "1.1.1.45", "activity": "", "evidence": [ { "id": "Q8SPX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPX7" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q8SPX7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 321, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q8SPX7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q8SPX7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.1.1.45", "ec_name": "L-gulonate + NAD(+) = 3-dehydro-L-gulonate + NADH + H(+).", "evidence": [ { "id": "1.1.1.45", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.45" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 3 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q6R4Q5-1", "uniprot_ac": "Q6R4Q5", "uniprot_id": "SC5AA_BOVIN", "mass": { "chemical_mass": 64726.0, "monoisotopic_mass": 64726.0 }, "refseq": { "ac": "NP_001001442", "name": "sodium/mannose cotransporter SLC5A10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001442" }, "gene_names": [ { "name": "SLC5A10", "type": "recommended", "evidence": [ { "id": "Q6R4Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5" } ] }, { "name": "SGLT5", "type": "synonym", "evidence": [ { "id": "NP_001001442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001442" }, { "id": "Q6R4Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5" } ] }, { "name": "SLC5A10", "type": "synonym", "evidence": [ { "id": "NP_001001442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001442" } ] } ], "protein_names": [ { "name": "Sodium/mannose cotransporter SLC5A10", "type": "recommended", "evidence": [ { "id": "Q6R4Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5/entry#names_and_taxonomy" } ] }, { "name": "Na(+)/glucose cotransporter 5", "type": "synonym", "evidence": [ { "id": "NP_001001442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001442" }, { "id": "Q6R4Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5/entry#names_and_taxonomy" } ] }, { "name": "Na+/glucose cotransporter-related protein", "type": "synonym", "evidence": [ { "id": "NP_001001442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001442" } ] }, { "name": "Sodium/glucose cotransporter 5", "type": "synonym", "evidence": [ { "id": "Q6R4Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5/entry#names_and_taxonomy" } ] }, { "name": "Solute carrier family 5 member 10", "type": "synonym", "evidence": [ { "id": "Q6R4Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5/entry#names_and_taxonomy" } ] }, { "name": "sodium/glucose cotransporter 5", "type": "synonym", "evidence": [ { "id": "NP_001001442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001442" } ] }, { "name": "sodium/mannose cotransporter SLC5A10", "type": "synonym", "evidence": [ { "id": "NP_001001442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001442" } ] }, { "name": "solute carrier family 5 (sodium/glucose cotransporter), member 10", "type": "synonym", "evidence": [ { "id": "NP_001001442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001442" } ] } ], "function": [ { "annotation": "Electrogenic Na+-coupled sugar symporter that actively transports D-mannose or D-fructose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2 (By similarity). Has likely evolved to enable renal reabsorption of D-mannose, an important constituent of oligosaccharide chains of glycoproteins. Contributes to dietary D-fructose reabsorption from glomerular filtrate across the brush border of the kidney (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q6R4Q5", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5#function" }, { "database": "UniProtKB", "id": "Q5SWY8", "url": "https://www.uniprot.org/uniprotkb/Q5SWY8#function" }, { "database": "UniProtKB", "id": "A0PJK1", "url": "https://www.uniprot.org/uniprotkb/A0PJK1#function" }, { "database": "UniProtKB", "id": "A0AAA9S6R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R9#function" }, { "database": "UniProtKB", "id": "ARBA00045692", "url": "https://www.uniprot.org/uniprotkb/ARBA00045692#function" }, { "database": "UniProtKB", "id": "A0A3Q1MC50", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC50#function" }, { "database": "UniProtKB", "id": "A0A3Q1MG49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MG49#function" } ] }, { "annotation": "Na+-dependent glucose cotransporters (SGLT)5 mRNA was found predominantly in bovine kidney, only at very low levels in bovine testes, skeletal muscle, and spleen", "evidence": [ { "database": "RefSeq", "id": "NP_001001442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001442" }, { "database": "PubMed", "id": "15591382", "url": "https://glygen.org/publication/PubMed/15591382" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6R4Q5", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC5A10", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5", "locus": { "chromosome": "19", "start_pos": 34214709, "end_pos": 34269734, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003700", "url": "https://www.ensembl.org/id/ENSBTAG00000003700" } ] } } ], "crossref": [ { "id": "Q6R4Q5", "url": "https://alphafold.ebi.ac.uk/entry/Q6R4Q5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003700", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003700", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "407227", "url": "https://www.ncbi.nlm.nih.gov/gene/407227", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018212", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018212", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038377", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038377", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:407227", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:407227", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LFGGMWS", "url": "https://omabrowser.org/oma/group/LFGGMWS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MC50", "url": "https://www.orthodb.org/?gene=A0A3Q1MC50", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MG49", "url": "https://www.orthodb.org/?gene=A0A3Q1MG49", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q6R4Q5", "url": "https://www.orthodb.org/?gene=Q6R4Q5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11819", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11819:SF128", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819:SF128", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00474", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00474", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-189200", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-189200", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001001442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001442", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "72907", "url": "https://www.rhea-db.org/rhea/72907", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "72915", "url": "https://www.rhea-db.org/rhea/72915", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MC50", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC50-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC50-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MG49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MG49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MG49-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MG49-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6R9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6R4Q5", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6R4Q5-1", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVDNSTSDAHTPGRQLTVVDIAIIAVYFALNVAVGIWSSCRASRNTVRGYFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWNATYVLLALAWVFVPIYLSSEIVTMPEYMQKRYGGQRIRMYLSVLSLLLSVFTKISIDLYAGALFVHICLGWNFYLSTVIMLAITALYTIAGGLTAVIYTDALQTLVMVAGAVILTIKAFEQIGGYEQLAEAYAQAVPSRTISNTTCHVPRADAMHMFRDPYTADLPWTGMTFGLTIMAAWYWCTDQVIVQRSLSARDLNHAKGGSILASYLKMLPMGLMVMPGMISRVLFPDDVGCVVPAECLRACGAEIGCSNIAYPKLVMELMPTGLRGLMVAVMMAALMSSLTSIFNSSSTLFTMDIWRRLRPRAGERELLLVGRLVIVVLVGVSVAWIPVLQGSNGGQLFIYMQSVTSSLAPPVTAVFVLGIFWRRANEQGAFWGLMAGLAVGATRLVLEFLHPAPPCGHPDTRPPILHGVHYLHFAVALFLLSGAVVVAGSLLTPHPQGVQIQSLTWWTLAQDLPLGVKTGDGRASQRHAFWARVCGVNAILLMCVNIFFYTYFA", "length": 597, "header": "sp|Q6R4Q5-1|SC5AA_BOVIN Isoform 1 of Sodium/mannose cotransporter SLC5A10 OS=Bos taurus OX=9913 GN=SLC5A10 PE=2 SV=1 CANONICAL=Q6R4Q5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MC50-1", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5/entry#A0A3Q1MC50-1", "sequence": { "sequence": "VDNSTSDAHTPGRQLTVVDIAIIAVYFALNVAVGIWSSCRASRNTVRGYFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWNATYVLLALAWVFVPIYLSSEIVTMPEYMQKRYGGQRIRMYLSVLSLLLSVFTKISIDLYAGALFVHICLGWNFYLSTVIMLAITALYTIAAFEQIGGYEQLAEAYAQAVPSRTISNTTCHVPRADAMHMFRDPYTADLPWTGMTFGLTIMAAWYWCTDQVIVQRSLSARDLNHAKGGSILASYLKMLPMGLMVMPGMISRVLFPDDVGCVVPAECLRACGAEIGCSNIAYPKLVMELMPTGLRGLMVAVMMAALMSSLTSIFNSSSTLFTMDIWRRLRPRAGERELLLVGRLVIVVLVGVSVAWIPVLQGSNGGQLFIYMQSVTSSLAPPVTAVFVLGIFWRRANEQGAFWGLMAGLAVGATRLVLEFLHPAPPCGHPDTRPPILHGVHYLHFAVALFLLSGAVVVAGSLLTPHPQGVQIQSLTWWTLAQDLPLGVKTGDGRASQRHAFWARVCGVNAILLMCVNIFFYTYFA", "length": 568, "header": "tr|A0A3Q1MC50-1|SC5AA_BOVIN Computationally mapped isoform of Sodium/mannose cotransporter SLC5A10 OS=Bos taurus OX=9913 GN=SLC5A10 PE=2 SV=2 CANONICAL=Q6R4Q5-1" }, "locus": { "chromosome": "19", "start_pos": 34269694, "end_pos": 34214926, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081820.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081820.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067892.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067892.2" } ] } }, { "isoform_ac": "A0A3Q1MG49-1", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5/entry#A0A3Q1MG49-1", "sequence": { "sequence": "MAVDNSTSDAHTPGRQLTVVDIAIIAVYFALNVAVGIWSSCRASRNTVRGYFLAGRDMTWWPVSAPQPLPPLLALGPHLTPRSATYVLLALAWVFVPIYLSSEIVTMPEYMQKRYGGQRIRMYLSVLSLLLSVFTKISIDLYAGALFVHICLGWNFYLSTVIMLAITALYTIAGGLTAVIYTDALQTLVMVAGAVILTIKAFEQIGGYEQLAEAYAQAVPSRTISNTTCHVPRADAMHMFRDPYTADLPWTGMTFGLTIMAAWYWCTDQVIVQRSLSARDLNHAKGGSILASYLKMLPMGLMVMPGMISRVLFPDDVGCVVPAECLRACGAEIGCSNIAYPKLVMELMPTGLRGLMVAVMMAALMSSLTSIFNSSSTLFTMDIWRRLRPRAGERELLLVGRLVIVVLVGVSVAWIPVLQGSNGGQLFIYMQSVTSSLAPPVTAVFVLGIFWRRANEQGAFWGLMAGLAVGATRLVLEFLHPAPPCGHPDTRPPILHGVHYLHFAVALFLLSGAVVVAGSLLTPHPQGVQIQSLTWWTLAQDLPLGVKTGDGRASQRHAFWARVCGVNAILLMCVNIFFYTYFA", "length": 583, "header": "tr|A0A3Q1MG49-1|SC5AA_BOVIN Computationally mapped isoform of Sodium/mannose cotransporter SLC5A10 OS=Bos taurus OX=9913 GN=SLC5A10 PE=2 SV=1 CANONICAL=Q6R4Q5-1" }, "locus": { "chromosome": "19", "start_pos": 34269700, "end_pos": 34214926, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075780.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075780.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070135.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070135.1" } ] } }, { "isoform_ac": "A0AAA9S6R9-1", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5/entry#A0AAA9S6R9-1", "sequence": { "sequence": "VDNSTSDAHTPGRQLTVVDIAIIAVYFALNVAVGIWSSCRASRNTVRGYFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWNATYVLLALAWVFVPIYLSSEIVTMPEYMQKRYGGQRIRMYLSVLSLLLSVFTKISIDLYAGALFVHICLGWNFYLSTVIMLAITALYTIAGGLTAVIYTDALQTLVMVAGAVILTIKAFEQIGGYEQLAEAYAQAVPSRTISNTTCHVPRADAMHMFRDPYTADLPWTGMTFGLTIMAAWYWCTDQVIVQRSLSARDLNHAKGGSILASYLKMLPMGLMVMPGMISRVLFPGLRGLMVAVMMAALMSSLTSIFNSSSTLFTMDIWRRLRPRAGERELLLVGRLVIVVLVGVSVAWIPVLQGSNGGQLFIYMQSVTSSLAPPVTAVFVLGIFWRRANEQGAFWGLMAGLAVGATRLVLEFLHPAPPCGHPDTRPPILHGVHYLHFAVALFLLSGAVVVAGSLLTPHPQGVQIQSLTWWTLAQDLPLGVKTGDGRASQRHAFWARVCGVNAILLMCVNIFFYTYFA", "length": 559, "header": "tr|A0AAA9S6R9-1|SC5AA_BOVIN Computationally mapped isoform of Sodium/mannose cotransporter SLC5A10 OS=Bos taurus OX=9913 GN=SLC5A10 PE=2 SV=1 CANONICAL=Q6R4Q5-1" }, "locus": { "chromosome": "19", "start_pos": 34269694, "end_pos": 34214926, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107955.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107955.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078986.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078986.1" } ] } }, { "isoform_ac": "Q6R4Q5-1", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5/entry#Q6R4Q5-1", "sequence": { "sequence": "MAVDNSTSDAHTPGRQLTVVDIAIIAVYFALNVAVGIWSSCRASRNTVRGYFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWNATYVLLALAWVFVPIYLSSEIVTMPEYMQKRYGGQRIRMYLSVLSLLLSVFTKISIDLYAGALFVHICLGWNFYLSTVIMLAITALYTIAGGLTAVIYTDALQTLVMVAGAVILTIKAFEQIGGYEQLAEAYAQAVPSRTISNTTCHVPRADAMHMFRDPYTADLPWTGMTFGLTIMAAWYWCTDQVIVQRSLSARDLNHAKGGSILASYLKMLPMGLMVMPGMISRVLFPDDVGCVVPAECLRACGAEIGCSNIAYPKLVMELMPTGLRGLMVAVMMAALMSSLTSIFNSSSTLFTMDIWRRLRPRAGERELLLVGRLVIVVLVGVSVAWIPVLQGSNGGQLFIYMQSVTSSLAPPVTAVFVLGIFWRRANEQGAFWGLMAGLAVGATRLVLEFLHPAPPCGHPDTRPPILHGVHYLHFAVALFLLSGAVVVAGSLLTPHPQGVQIQSLTWWTLAQDLPLGVKTGDGRASQRHAFWARVCGVNAILLMCVNIFFYTYFA", "length": 597, "header": "sp|Q6R4Q5-1|SC5AA_BOVIN Isoform 1 of Sodium/mannose cotransporter SLC5A10 OS=Bos taurus OX=9913 GN=SLC5A10 PE=2 SV=1 CANONICAL=Q6R4Q5-1" }, "locus": { "chromosome": "19", "start_pos": 34269700, "end_pos": 34214926, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004823.3", "url": "https://www.ensembl.org/id/ENSBTAT00000004823.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004823.2", "url": "https://www.ensembl.org/id/ENSBTAP00000004823.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 5, "start_aa": "Asn", "end_pos": 5, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn5", "evidence": [ { "id": "Q6R4Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 97, "start_aa": "Asn", "end_pos": 97, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn97", "evidence": [ { "id": "Q6R4Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Cloning and expression of bovine sodium/glucose cotransporters.", "journal": "J. Dairy Sci.", "date": "2005", "authors": "Zhao F-Q, Zheng Y-C, Wall E H, McFadden T B", "evidence": [ { "database": "UniProtKB", "id": "Q6R4Q5", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5" }, { "database": "RefSeq", "id": "NP_001001442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001442" } ], "reference": [ { "type": "PubMed", "id": "15591382", "url": "https://glygen.org/publication/PubMed/15591382" } ] } ], "pathway": [ { "id": "bta:407227", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:407227", "resource": "KEGG Pathway" }, { "id": "R-BTA-189200", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-189200", "resource": "Reactome", "description": "Cellular hexose transport" } ], "orthologs": [ { "uniprot_canonical_ac": "A0PJK1-1", "protein_name": "Sodium/mannose cotransporter SLC5A10", "gene_name": "SLC5A10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAANSTSDLHTPGTQLSVADIIVITVYFALNVAVGIWSSCRASRNTVNGYFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWNATYVLLALAWVFVPIYISSEIVTLPEYIQKRYGGQRIRMYLSVLSLLLSVFTKISLDLYAGALFVHICLGWNFYLSTILTLGITALYTIAGGLAAVIYTDALQTLIMVVGAVILTIKAFDQIGGYGQLEAAYAQAIPSRTIANTTCHLPRTDAMHMFRDPHTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARDLNHAKAGSILASYLKMLPMGLIIMPGMISRALFPDDVGCVVPSECLRACGAEVGCSNIAYPKLVMELMPIGLRGLMIAVMLAALMSSLTSIFNSSSTLFTMDIWRRLRPRSGERELLLVGRLVIVALIGVSVAWIPVLQDSNSGQLFIYMQSVTSSLAPPVTAVFVLGVFWRRANEQGAFWGLIAGLVVGATRLVLEFLNPAPPCGEPDTRPAVLGSIHYLHFAVALFALSGAVVVAGSLLTPPPQSVQIENLTWWTLAQDVPLGTKAGDGQTPQKHAFWARVCGFNAILLMCVNIFFYAYFA", "length": 596 }, "evidence": [ { "id": "Q6R4Q5", "url": "https://omabrowser.org/oma/group/Q6R4Q5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5SWY8-1", "protein_name": "Sodium/mannose cotransporter SLC5A10", "gene_name": "Slc5a10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGNSTGDAHVPGSQLSVTDIIVISVYFALNVAVGIWSACRANKNTVSGYFLAGRDMAWWPIGASLFASSEGSGLFVGLAGSGAAGGLAVAGFEWNATYVLLALAWVFVPIYISSEIVTLPEYIQKRFGGQRIRTYLSVLSLMLSVFTKISIDLYAGALFVHICLGWNFYLSTILTLAITALYTIAGGLATVIYTDALQTIIMVVGAVILAVKAFNQIGGYEQLEAAYAQAIPSRTIPNTTCHLPRADAMHMFRDPSTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARNLNHAKAGSILASYLKMLPMGLMIMPGMISRVLFPDDVGCVVPSECLRACGAEIGCSNIAYPKLVMELMPIGLRGLMIAVMMAALLSSLTSIFNSSSTLFTMDIWRQLRPSAGERELLLVGRLVIVVLIGVSVAWIPVLQGSNSGQLFIYMQSVTSSLAPPVTAIFILGIFWRRANEQGAFWGLMAGLVVGALRLVLEFLYPEPPCGQIDTRPAPLRSLHYLHFAIALFLLTCAVMAAGSLLSPPPQQRQIENLTWWTLAPNWSLGTKTGDGQTPQKRAFWARVCNVNAIFLMCVNIFFYAYFA", "length": 596 }, "evidence": [ { "id": "Q6R4Q5", "url": "https://omabrowser.org/oma/group/Q6R4Q5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q6R4Q5", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "Q6R4Q5", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "mannose:sodium symporter activity", "id": "GO:0140929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140929", "evidence": [ { "database": "UniProtKB", "id": "Q6R4Q5", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5" } ], "pmid": "" }, { "name": "fructose:sodium symporter activity", "id": "GO:0140930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140930", "evidence": [ { "database": "UniProtKB", "id": "Q6R4Q5", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5" } ], "pmid": "" }, { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "Q6R4Q5", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5" } ], "pmid": "" }, { "name": "carbohydrate:monoatomic cation symporter activity", "id": "GO:0005402", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005402", "evidence": [ { "database": "UniProtKB", "id": "Q6R4Q5", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5" } ], "pmid": "" }, { "name": "hexose transmembrane transporter activity", "id": "GO:0015149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015149", "evidence": [ { "database": "UniProtKB", "id": "Q6R4Q5", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5" } ], "pmid": "" }, { "name": "solute:sodium symporter activity", "id": "GO:0015370", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015370", "evidence": [ { "database": "UniProtKB", "id": "Q6R4Q5", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "sodium ion transport", "id": "GO:0006814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006814", "evidence": [ { "database": "UniProtKB", "id": "Q6R4Q5", "url": "https://www.uniprot.org/uniprotkb/Q6R4Q5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 240, "end_pos": 242, "annotation": "n_glycosylation_sequon" }, { "start_pos": 387, "end_pos": 389, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "72907", "name": "", "equation": "D-mannose(out) + Na(+)(out) = D-mannose(in) + Na(+)(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "72907", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/72907" } ] }, { "id": "72915", "name": "", "equation": "D-fructopyranose(out) + Na(+)(out) = D-fructopyranose(in) + Na(+)(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "72915", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/72915" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q6R4Q5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 597, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q6R4Q5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q6R4Q5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 5, 97 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 240, "end_pos": 242 }, { "start_pos": 387, "end_pos": 389 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 97, "end_pos": 99 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZCI8-1", "uniprot_ac": "Q3ZCI8", "uniprot_id": "REEP4_BOVIN", "mass": { "chemical_mass": 29597.0, "monoisotopic_mass": 29597.0 }, "refseq": { "ac": "NP_001029705", "name": "receptor expression-enhancing protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029705" }, "gene_names": [ { "name": "REEP4", "type": "recommended", "evidence": [ { "id": "Q3ZCI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8" } ] }, { "name": "REEP4", "type": "synonym", "evidence": [ { "id": "NP_001029705", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029705" } ] } ], "protein_names": [ { "name": "Receptor expression-enhancing protein 4", "type": "recommended", "evidence": [ { "id": "Q3ZCI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8/entry#names_and_taxonomy" } ] }, { "name": "receptor expression-enhancing protein 4", "type": "synonym", "evidence": [ { "id": "NP_001029705", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029705" } ] } ], "function": [ { "annotation": "Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.", "evidence": [ { "database": "UniProtKB", "id": "A0A452DIE6", "url": "https://www.uniprot.org/uniprotkb/A0A452DIE6#function" }, { "database": "UniProtKB", "id": "ARBA00037282", "url": "https://www.uniprot.org/uniprotkb/ARBA00037282#function" }, { "database": "UniProtKB", "id": "A0AAA9SA35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA35#function" }, { "database": "UniProtKB", "id": "A0A3Q1MDF2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDF2#function" }, { "database": "UniProtKB", "id": "Q3ZCI8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "REEP4", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8", "locus": { "chromosome": "8", "start_pos": 69452233, "end_pos": 69456231, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009504", "url": "https://www.ensembl.org/id/ENSBTAG00000009504" } ] } } ], "crossref": [ { "id": "Q3ZCI8", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCI8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009504", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009504", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "519613", "url": "https://www.ncbi.nlm.nih.gov/gene/519613", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004345", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004345", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519613", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519613", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DTDDECW", "url": "https://omabrowser.org/oma/group/DTDDECW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MDF2", "url": "https://www.orthodb.org/?gene=A0A3Q1MDF2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIE6", "url": "https://www.orthodb.org/?gene=A0A452DIE6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZCI8", "url": "https://www.orthodb.org/?gene=Q3ZCI8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12300", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12300", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12300:SF36", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12300:SF36", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03134", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03134", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029705", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDF2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDF2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIE6", "url": "https://www.uniprot.org/uniprotkb/A0A452DIE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIE6-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIE6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA35-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCI8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCI8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSWMICRLVVLVFGMLYPAYASYKAVKTKNIREYVRWMMYWIVFALFMAVETFTDIFISWFPFYYEIKMAFVLWLLSPYTRGASMLYRKFVHPSLSRHEKEIDTYIVQAKERSYETVLSFGKRGLNIAASAAVQAATKSQGALAGKLRSFSMQDLRTIPDGPAPTYQDPLYLEDQVPHRRPPIGYRAGGLRDSDTDNECWSDTEVVPQPPARPREKPLGRSQSLRVIKRKPLAREGTSRSLKVRTRKKTAPSDMDS", "length": 257, "header": "sp|Q3ZCI8-1|REEP4_BOVIN Isoform 1 of Receptor expression-enhancing protein 4 OS=Bos taurus OX=9913 GN=REEP4 PE=2 SV=1 CANONICAL=Q3ZCI8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MDF2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8/entry#A0A3Q1MDF2-1", "sequence": { "sequence": "MGHFCRPEQAWGVCKQQGREVASRALTQAQVVQAKREEQGRLVFGMLYPAYASYKAVKTKNIREYVRWMMYWIVFALFMAVETFTDIFISWFPFYYEIKMAFVLWLLSPYTRGASMLYRKFVHPSLSRHEKEIDTYIVQAKERSYETVLSFGKRGLNIAASAAVQAATKSQGALAGKLRSFSMQDLRTIPDGPAPTYQDPLYLEDQVPHRRPPIGYRAGGLRDSDTDNECWSDTEVVPQPPARPREKPLGRSQSLRVIKRKPLAREGTSRSLKVRTRKKTAPSDMDS", "length": 287, "header": "tr|A0A3Q1MDF2-1|REEP4_BOVIN Computationally mapped isoform of Receptor expression-enhancing protein 4 OS=Bos taurus OX=9913 GN=REEP4 PE=2 SV=2 CANONICAL=Q3ZCI8-1" }, "locus": { "chromosome": "8", "start_pos": 69455153, "end_pos": 69452654, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073453.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073453.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068957.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068957.2" } ] } }, { "isoform_ac": "A0A452DIE6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8/entry#A0A452DIE6-1", "sequence": { "sequence": "MVSWMICRLVVLVFGMLYPAYASYKAVKTKNIREYVRWMMYWIVFALFMAVETFTDIFISWFPFYYEIKMAFVLWLLSPYTRGASMLYRKFVHPSLSRHEKEIDTYIVQAKERSYETVLSFGKRGLNIAASAAVQAATKSQGALAGKLRSFSMQDLRTIPDGPAPTYQDPLYLEDQVPHRRPPIGEWAEGPETVPPRERNGFLPWGWRKAWLSLPPALRLCQCLALPPGSFSSTQGTGQGACETVTLIMSVGPTRKWSPSHQPGPERSRWAAARACV", "length": 277, "header": "tr|A0A452DIE6-1|REEP4_BOVIN Computationally mapped isoform of Receptor expression-enhancing protein 4 OS=Bos taurus OX=9913 GN=REEP4 PE=2 SV=1 CANONICAL=Q3ZCI8-1" }, "locus": { "chromosome": "8", "start_pos": 69455793, "end_pos": 69452654, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012505.3", "url": "https://www.ensembl.org/id/ENSBTAT00000012505.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012505.3", "url": "https://www.ensembl.org/id/ENSBTAP00000012505.3" } ] } }, { "isoform_ac": "A0AAA9SA35-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8/entry#A0AAA9SA35-1", "sequence": { "sequence": "MVSWMICRLVVLVFGMLYPAYASYKAVKTKNIREYVRWMMYWIVFALFMAVETFTDIFISWFPFYYEIKMAFVLWLLSPYTRGASMLYRKFVHPSLSRHEKEIDTYIVQAKERSYETVLSFGKRGLNIAASAAVQAATKGTGQGACETVTLIMSVGPTRKWSPSHQPGPERSRW", "length": 174, "header": "tr|A0AAA9SA35-1|REEP4_BOVIN Computationally mapped isoform of Receptor expression-enhancing protein 4 OS=Bos taurus OX=9913 GN=REEP4 PE=2 SV=1 CANONICAL=Q3ZCI8-1" }, "locus": { "chromosome": "8", "start_pos": 69455793, "end_pos": 69452863, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134280.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134280.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080781.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080781.1" } ] } }, { "isoform_ac": "Q3ZCI8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8/entry#Q3ZCI8-1", "sequence": { "sequence": "MVSWMICRLVVLVFGMLYPAYASYKAVKTKNIREYVRWMMYWIVFALFMAVETFTDIFISWFPFYYEIKMAFVLWLLSPYTRGASMLYRKFVHPSLSRHEKEIDTYIVQAKERSYETVLSFGKRGLNIAASAAVQAATKSQGALAGKLRSFSMQDLRTIPDGPAPTYQDPLYLEDQVPHRRPPIGYRAGGLRDSDTDNECWSDTEVVPQPPARPREKPLGRSQSLRVIKRKPLAREGTSRSLKVRTRKKTAPSDMDS", "length": 257, "header": "sp|Q3ZCI8-1|REEP4_BOVIN Isoform 1 of Receptor expression-enhancing protein 4 OS=Bos taurus OX=9913 GN=REEP4 PE=2 SV=1 CANONICAL=Q3ZCI8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 152, "end_pos": 152, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8" } ], "site_lbl": "Ser152" }, { "start_pos": 194, "end_pos": 194, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8" } ], "site_lbl": "Ser194" }, { "start_pos": 196, "end_pos": 196, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8" } ], "site_lbl": "Thr196" }, { "start_pos": 202, "end_pos": 202, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8" } ], "site_lbl": "Ser202" }, { "start_pos": 250, "end_pos": 250, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8" } ], "site_lbl": "Thr250" }, { "start_pos": 253, "end_pos": 253, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8" } ], "site_lbl": "Ser253" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:519613", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519613", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RMB6-1", "protein_name": "Receptor expression-enhancing protein", "gene_name": "REEP4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVSWMICRLVVLVFGMLYPAYASYKAVKTKNIREYVRWMMYWIVFALFMAVETFTDIFVSWFPFYYEIKMAFVLWLLSPYTKGASLLYRKFVHPSLSRHEKEIDTYIVQAKERSYETVLSFGKRGLNIAASAAVQAATKSQGALAGRLRSFSMQDLRSIPDDSTPVYQDPLYLEDQVPRRRPPIGYRAGGLQDSDTEEECWSDTEAVPQPPARPREKPLGRSQSLRLAKRKPLTREGTSRSLKVRTRKKTAPSDMDS", "length": 257 }, "evidence": [ { "id": "Q3ZCI8", "url": "https://omabrowser.org/oma/group/Q3ZCI8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GUX6-1", "protein_name": "Receptor expression-enhancing protein", "gene_name": "Reep4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVSWMICRLVVLVFGMLYPAYASYKAVKSKNIREYVRWMMYWIVFAIFMAAETFTDVFISWFPFYYEIKMAFVLWLLSPYTKGASLLYRKFVHPSLSRHEKEIDACIVQAKERSYETMLSFGKRSLNIAASAAVQAATKSQGALAGRLRSFSMQDLRSIPDTPAPTYQDPLYLEDQIPRRRPPIGYRPGGLQDSDTEDECWSDNEITPQPTVRPREKPLGRSQSLRVVKRKPLIREGTSRSLKVRTRKKTMPSDMDS", "length": 257 }, "evidence": [ { "id": "Q3ZCI8", "url": "https://omabrowser.org/oma/group/Q3ZCI8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q4QQW1-1", "protein_name": "Receptor expression-enhancing protein 4", "gene_name": "Reep4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVSWMICRLVVLIFGMLYPAYASYKAVKSKNIREYVRWMMYWIVFAIFMAAETFTDIFISWFPFYYEIKMAFVLWLLSPYTKGASLLYRKFVHPSLSRHEKEIDACIVQAKERSYETMLSFGKRSLNMAASAAVQAATKSQGALAGRLRSFSMQDLRSIPDTSAPTYQDPLYLEDQAPRRRPPIGYRPGGLQDSDTEDECWSDNEIAPQPPVRPREKPLSRSQSLRVVKRKPLVREGTSRSLKVRTRKKTIPSDLDS", "length": 257 }, "evidence": [ { "id": "Q3ZCI8", "url": "https://omabrowser.org/oma/group/Q3ZCI8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9H6H4-1", "protein_name": "Receptor expression-enhancing protein 4", "gene_name": "REEP4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVSWMICRLVVLVFGMLCPAYASYKAVKTKNIREYVRWMMYWIVFALFMAAEIVTDIFISWFPFYYEIKMAFVLWLLSPYTKGASLLYRKFVHPSLSRHEKEIDAYIVQAKERSYETVLSFGKRGLNIAASAAVQAATKSQGALAGRLRSFSMQDLRSISDAPAPAYHDPLYLEDQVSHRRPPIGYRAGGLQDSDTEDECWSDTEAVPRAPARPREKPLIRSQSLRVVKRKPPVREGTSRSLKVRTRKKTVPSDVDS", "length": 257 }, "evidence": [ { "id": "Q3ZCI8", "url": "https://omabrowser.org/oma/group/Q3ZCI8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "endoplasmic reticulum tubular network organization", "id": "GO:0071786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071786", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8" } ], "pmid": "" }, { "name": "mitotic nuclear membrane reassembly", "id": "GO:0007084", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007084", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8" } ], "pmid": "" }, { "name": "nuclear envelope organization", "id": "GO:0006998", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006998", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8" } ], "pmid": "" }, { "name": "cytoplasmic microtubule", "id": "GO:0005881", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005881", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8" } ], "pmid": "" }, { "name": "endoplasmic reticulum tubular network", "id": "GO:0071782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071782", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCI8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 257, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCI8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCI8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 152, 194, 196, 202, 250, 253 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q5E9D5-1", "uniprot_ac": "Q5E9D5", "uniprot_id": "DEST_BOVIN", "mass": { "chemical_mass": 18506.0, "monoisotopic_mass": 18506.0 }, "refseq": { "ac": "NP_001015586", "name": "destrin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015586" }, "gene_names": [ { "name": "DSTN", "type": "recommended", "evidence": [ { "id": "Q5E9D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9D5" } ] }, { "name": "DSTN", "type": "synonym", "evidence": [ { "id": "NP_001015586", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015586" } ] } ], "protein_names": [ { "name": "Destrin", "type": "recommended", "evidence": [ { "id": "Q5E9D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9D5/entry#names_and_taxonomy" } ] }, { "name": "ADF", "type": "synonym", "evidence": [ { "id": "NP_001015586", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015586" }, { "id": "Q5E9D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9D5/entry#names_and_taxonomy" } ] }, { "name": "Actin-depolymerizing factor", "type": "synonym", "evidence": [ { "id": "Q5E9D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9D5/entry#names_and_taxonomy" } ] }, { "name": "actin-depolymerizing factor", "type": "synonym", "evidence": [ { "id": "NP_001015586", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015586" } ] }, { "name": "destrin", "type": "synonym", "evidence": [ { "id": "NP_001015586", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015586" } ] } ], "function": [ { "annotation": "Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9D5", "url": "https://www.uniprot.org/uniprotkb/Q5E9D5#function" }, { "database": "UniProtKB", "id": "P60981", "url": "https://www.uniprot.org/uniprotkb/P60981#function" }, { "database": "UniProtKB", "id": "Q9R0P5", "url": "https://www.uniprot.org/uniprotkb/Q9R0P5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9D5", "url": "https://www.uniprot.org/uniprotkb/Q5E9D5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DSTN", "url": "https://www.uniprot.org/uniprotkb/Q5E9D5", "locus": { "chromosome": "13", "start_pos": 37980310, "end_pos": 37954743, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015434", "url": "https://www.ensembl.org/id/ENSBTAG00000015434" } ] } } ], "crossref": [ { "id": "Q5E9D5", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9D5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd11286", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11286", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513267", "url": "https://www.ncbi.nlm.nih.gov/gene/513267", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513267", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513267", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ITFYSWS", "url": "https://omabrowser.org/oma/group/ITFYSWS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MFL7", "url": "https://www.orthodb.org/?gene=A0A3Q1MFL7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1ML30", "url": "https://www.orthodb.org/?gene=A0A3Q1ML30", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5E9D5", "url": "https://www.orthodb.org/?gene=Q5E9D5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11913", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11913", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00241", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00241", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015586", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFL7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFL7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFL7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ML30", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ML30-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML30-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFT4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFT4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9D5", "url": "https://www.uniprot.org/uniprotkb/Q5E9D5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9D5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9D5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDVGVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASSKDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV", "length": 165, "header": "sp|Q5E9D5-1|DEST_BOVIN Isoform 1 of Destrin OS=Bos taurus OX=9913 GN=DSTN PE=2 SV=3 CANONICAL=Q5E9D5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MFL7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9D5/entry#A0A3Q1MFL7-1", "sequence": { "sequence": "MMGVDFLIISAFQEHRAQASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDVGVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASSKDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV", "length": 182, "header": "tr|A0A3Q1MFL7-1|DEST_BOVIN Computationally mapped isoform of Destrin OS=Bos taurus OX=9913 GN=DSTN PE=2 SV=2 CANONICAL=Q5E9D5-1" }, "locus": { "chromosome": "13", "start_pos": 37979363, "end_pos": 37958303, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073890.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073890.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067752.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067752.2" } ] } }, { "isoform_ac": "A0A3Q1ML30-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9D5/entry#A0A3Q1ML30-1", "sequence": { "sequence": "ASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDVGVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASSKDAIKKKFQGIKHECQANGPEDLNRACIAEKLGPGRTSSPRVACNCTCGVEQV", "length": 172, "header": "tr|A0A3Q1ML30-1|DEST_BOVIN Computationally mapped isoform of Destrin OS=Bos taurus OX=9913 GN=DSTN PE=2 SV=3 CANONICAL=Q5E9D5-1" }, "locus": { "chromosome": "13", "start_pos": 37980307, "end_pos": 37974528, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069150.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069150.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069973.3", "url": "https://www.ensembl.org/id/ENSBTAP00000069973.3" } ] } }, { "isoform_ac": "A0AAA9TFT4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9D5/entry#A0AAA9TFT4-1", "sequence": { "sequence": "MDSSVQGLHRASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDVGVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASSKDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV", "length": 174, "header": "tr|A0AAA9TFT4-1|DEST_BOVIN Computationally mapped isoform of Destrin OS=Bos taurus OX=9913 GN=DSTN PE=2 SV=1 CANONICAL=Q5E9D5-1" }, "locus": { "chromosome": "13", "start_pos": 37979363, "end_pos": 37959750, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129812.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129812.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095041.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095041.1" } ] } }, { "isoform_ac": "Q5E9D5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9D5/entry#Q5E9D5-1", "sequence": { "sequence": "MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDVGVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASSKDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV", "length": 165, "header": "sp|Q5E9D5-1|DEST_BOVIN Isoform 1 of Destrin OS=Bos taurus OX=9913 GN=DSTN PE=2 SV=3 CANONICAL=Q5E9D5-1" }, "locus": { "chromosome": "13", "start_pos": 37979363, "end_pos": 37954821, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020512.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020512.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020512.3", "url": "https://www.ensembl.org/id/ENSBTAP00000020512.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 3, "end_pos": 3, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9D5", "url": "https://www.uniprot.org/uniprotkb/Q5E9D5" } ], "site_lbl": "Ser3" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9D5", "url": "https://www.uniprot.org/uniprotkb/Q5E9D5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:513267", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513267", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3GVX2-1", "protein_name": "Destrin", "gene_name": "Dstn", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASGVQVADEVCRIFYDMKVRKCSSPEEIKKRKKAVIFCLSADKKCIVVEEGKEILVGDVGDTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPEQAPLKSKMIYASSKDAIKKKFQGIKHEYQANGPEDLNRTSIAEKLGGSLIVAFEGSPV", "length": 165 }, "evidence": [ { "id": "Q5E9D5", "url": "https://omabrowser.org/oma/group/Q5E9D5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P45594-1", "protein_name": "Cofilin/actin-depolymerizing factor homolog", "gene_name": "tsr", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MASGVTVSDVCKTTYEEIKKDKKHRYVIFYIRDEKQIDVETVADRNAEYDQFLEDIQKCGPGECRYGLFDFEYMHQCQGTSESSKKQKLFLMSWCPDTAKVKKKMLYSSSFDALKKSLVGVQKYIQATDLSEASREAVEEKLRATDRQ", "length": 148 }, "evidence": [ { "id": "Q5E9D5", "url": "https://omabrowser.org/oma/group/Q5E9D5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P60981-1", "protein_name": "Destrin", "gene_name": "DSTN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDVGVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASSKDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV", "length": 165 }, "evidence": [ { "id": "Q5E9D5", "url": "https://omabrowser.org/oma/group/Q5E9D5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P60982-1", "protein_name": "Destrin", "gene_name": "DSTN", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDVGVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASSKDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV", "length": 165 }, "evidence": [ { "id": "Q5E9D5", "url": "https://omabrowser.org/oma/group/Q5E9D5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q7M0E3-1", 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The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. 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"url": "https://www.uniprot.org/uniprotkb/Q5E988" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPS5", "url": "https://www.uniprot.org/uniprotkb/Q5E988", "locus": { "chromosome": "18", "start_pos": 65665845, "end_pos": 65660240, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015989", "url": "https://www.ensembl.org/id/ENSBTAG00000015989" } ] } } ], "crossref": [ { "id": "Q5E988", "url": "https://alphafold.ebi.ac.uk/entry/Q5E988", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015989", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015989", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14867", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14867", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506229", "url": "https://www.ncbi.nlm.nih.gov/gene/506229", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000235", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000235", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020606", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020606", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023798", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023798", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036823", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036823", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506229", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506229", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KMNIVER", "url": "https://omabrowser.org/oma/group/KMNIVER/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E988", "url": "https://www.orthodb.org/?gene=Q5E988", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11205", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11205", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00177", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00177", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015531", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MID4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MID4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MID4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MID4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYL2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E988", "url": "https://www.uniprot.org/uniprotkb/Q5E988", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E988-1", "url": "https://www.uniprot.org/uniprotkb/Q5E988-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTEWETAAPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKRFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR", "length": 204, "header": "sp|Q5E988-1|RS5_BOVIN Isoform 1 of Small ribosomal subunit protein uS7 OS=Bos taurus OX=9913 GN=RPS5 PE=2 SV=3 CANONICAL=Q5E988-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MID4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E988/entry#A0A3Q1MID4-1", "sequence": { "sequence": "MTEWETAAPAVAETPDIKLFGKWSTDDVQINDISLQVATVFPRRWFLPQYHFPQVDYIAVKEKYAKYLPHSAGRYAAKRFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR", "length": 223, "header": "tr|A0A3Q1MID4-1|RS5_BOVIN Computationally mapped isoform of Small ribosomal subunit protein uS7 OS=Bos taurus OX=9913 GN=RPS5 PE=2 SV=2 CANONICAL=Q5E988-1" }, "locus": { "chromosome": "18", "start_pos": 65665800, "end_pos": 65661039, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073108.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073108.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074064.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074064.2" } ] } }, { "isoform_ac": "A0AAA9RYL2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E988/entry#A0AAA9RYL2-1", "sequence": { "sequence": "MTEWETAAPAVAETPDIKLFGKWSTDDVQINDISLQNPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR", "length": 134, "header": "tr|A0AAA9RYL2-1|RS5_BOVIN Computationally mapped isoform of Small ribosomal subunit protein uS7 OS=Bos taurus OX=9913 GN=RPS5 PE=2 SV=1 CANONICAL=Q5E988-1" }, "locus": { "chromosome": "18", "start_pos": 65665800, "end_pos": 65661039, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093289.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093289.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076220.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076220.1" } ] } }, { "isoform_ac": "Q5E988-1", "url": "https://www.uniprot.org/uniprotkb/Q5E988/entry#Q5E988-1", "sequence": { "sequence": "MTEWETAAPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKRFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR", "length": 204, "header": "sp|Q5E988-1|RS5_BOVIN Isoform 1 of Small ribosomal subunit protein uS7 OS=Bos taurus OX=9913 GN=RPS5 PE=2 SV=3 CANONICAL=Q5E988-1" }, "locus": { "chromosome": "18", "start_pos": 65665800, "end_pos": 65661039, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021268.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021268.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021268.3", "url": "https://www.ensembl.org/id/ENSBTAP00000021268.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 142, "end_pos": 142, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E988", "url": "https://www.uniprot.org/uniprotkb/Q5E988" } ], "site_lbl": "Ser142" }, { "start_pos": 14, "end_pos": 14, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E988", "url": "https://www.uniprot.org/uniprotkb/Q5E988" } ], "site_lbl": "Thr14" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E988", "url": "https://www.uniprot.org/uniprotkb/Q5E988" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:506229", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506229", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72649", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "resource": "Reactome", "description": "Translation initiation complex formation" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "resource": "Reactome", "description": "Formation of the ternary complex, and subsequently, the 43S complex" }, { "id": "R-BTA-72702", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "resource": "Reactome", "description": "Ribosomal scanning and start codon recognition" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "F2Z5E6-1", "protein_name": "Small ribosomal subunit protein uS7", "gene_name": "RPS5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTEWETAAPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKRFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR", "length": 204 }, "evidence": [ { "id": "Q5E988", "url": "https://omabrowser.org/oma/group/Q5E988/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P24050-1", "protein_name": "Small ribosomal subunit protein uS7", "gene_name": "Rps5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTEWETATPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAANGFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINARKGSSNSYAIKKKDELERVAKSNR", "length": 204 }, "evidence": [ { "id": "Q5E988", "url": "https://omabrowser.org/oma/group/Q5E988/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P26783-1", "protein_name": "Small ribosomal subunit protein uS7", "gene_name": "RPS5", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSDTEAPVEVQEDFEVVEEFTPVVLATPIPEEVQQAQTEIKLFNKWSFEEVEVKDASLVDYVQVRQPIFVAHTAGRYANKRFRKAQCPIIERLTNSLMMNGRNNGKKLKAVRIIKHTLDIINVLTDQNPIQVVVDAITNTGPREDTTRVGGGGAARRQAVDVSPLRRVNQAIALLTIGAREAAFRNIKTIAETLAEELINAAKGSSTSYAIKKKDELERVAKSNR", "length": 225 }, "evidence": [ { "id": "Q5E988", "url": "https://omabrowser.org/oma/group/Q5E988/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P46782-1", "protein_name": "Small ribosomal subunit protein uS7", "gene_name": "RPS5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTEWETAAPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKRFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR", "length": 204 }, "evidence": [ { "id": "Q5E988", "url": "https://omabrowser.org/oma/group/Q5E988/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P97461-1", "protein_name": "Small ribosomal subunit protein uS7", "gene_name": "Rps5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTEWEAATPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKRFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR", "length": 204 }, "evidence": [ { "id": "Q5E988", "url": "https://omabrowser.org/oma/group/Q5E988/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54MA6-1", "protein_name": "Small ribosomal subunit protein uS7", "gene_name": "rps5", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTSEVALFGKWSYSGVTCPDISLQDYICVKKNVFTPHSAGRYNKVRFRKAQCPIVERLANSMMMFGRNAGKKVMAVRIIEQAFEIIYLLTDKNPLQVLVEAVMNSGPREDSTRIGSAGTVRRQAVDVSPMRRVNHAVYLLTQGTRAAAFRNIRTVAECLADELINASKGSPNSYSIKQKDALERTAKSHR", "length": 190 }, "evidence": [ { "id": "Q5E988", "url": "https://omabrowser.org/oma/group/Q5E988/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9ZUT9-1", "protein_name": "Small ribosomal subunit protein uS7z", "gene_name": "RPS5A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAASAEIDAEIQQQLTNEVKLFNRWSFDDVSVTDISLVDYIGVQPSKHATFVPHTAGRYSVKRFRKAQCPIVERLTNSLMMHGRNNGKKLMAVRIVKHAMEIIHLLSDLNPIQVIIDAIVNSGPREDATRIGSAGVVRRQAVDISPLRRVNQAIFLLTTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDEIERVAKANR", "length": 207 }, "evidence": [ { "id": "Q5E988", "url": "https://omabrowser.org/oma/group/Q5E988/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "Q5E988", "url": "https://www.uniprot.org/uniprotkb/Q5E988" } ], "pmid": "" }, { "name": "rRNA binding", "id": "GO:0019843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019843", "evidence": [ { "database": "UniProtKB", "id": "Q5E988", "url": "https://www.uniprot.org/uniprotkb/Q5E988" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q5E988", "url": "https://www.uniprot.org/uniprotkb/Q5E988" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q5E988", "url": "https://www.uniprot.org/uniprotkb/Q5E988" } ], "pmid": "" }, { "name": "ribosomal small subunit biogenesis", "id": "GO:0042274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042274", "evidence": [ { "database": "UniProtKB", "id": "Q5E988", "url": "https://www.uniprot.org/uniprotkb/Q5E988" } ], "pmid": "" }, { "name": "regulation of translational fidelity", "id": "GO:0006450", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006450", "evidence": [ { "database": "UniProtKB", "id": "Q5E988", "url": "https://www.uniprot.org/uniprotkb/Q5E988" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "Q5E988", "url": "https://www.uniprot.org/uniprotkb/Q5E988" } ], "pmid": "" }, { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "Q5E988", "url": "https://www.uniprot.org/uniprotkb/Q5E988" } ], "pmid": "" }, { "name": "cytosolic small ribosomal subunit", "id": "GO:0022627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022627", "evidence": [ { "database": "UniProtKB", "id": "Q5E988", "url": "https://www.uniprot.org/uniprotkb/Q5E988" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q5E988", "url": "https://www.uniprot.org/uniprotkb/Q5E988" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "Q5E988", "url": "https://www.uniprot.org/uniprotkb/Q5E988" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q5E988", "url": "https://www.uniprot.org/uniprotkb/Q5E988" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E988-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 204, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E988-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E988" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 14, 142 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZC98-1", "uniprot_ac": "Q3ZC98", "uniprot_id": "NUP85_BOVIN", "mass": { "chemical_mass": 74710.0, "monoisotopic_mass": 74710.0 }, "refseq": { "ac": "NP_001029559", "name": "nuclear pore complex protein Nup85", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029559" }, "gene_names": [ { "name": "NUP85", "type": "recommended", "evidence": [ { "id": "Q3ZC98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98" } ] }, { "name": "NUP85", "type": "synonym", "evidence": [ { "id": "NP_001029559", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029559" } ] } ], "protein_names": [ { "name": "Nuclear pore complex protein Nup85", "type": "recommended", "evidence": [ { "id": "Q3ZC98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98/entry#names_and_taxonomy" } ] }, { "name": "85 kDa nucleoporin", "type": "synonym", "evidence": [ { "id": "NP_001029559", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029559" }, { "id": "Q3ZC98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98/entry#names_and_taxonomy" } ] }, { "name": "Nucleoporin Nup85", "type": "synonym", "evidence": [ { "id": "Q3ZC98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98/entry#names_and_taxonomy" } ] }, { "name": "nuclear pore complex protein Nup85", "type": "synonym", "evidence": [ { "id": "NP_001029559", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029559" } ] }, { "name": "nucleoporin NUP85", "type": "synonym", "evidence": [ { "id": "NP_001029559", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029559" } ] } ], "function": [ { "annotation": "Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade. Involved in nephrogenesis.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC98", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98#function" }, { "database": "UniProtKB", "id": "Q9BW27", "url": "https://www.uniprot.org/uniprotkb/Q9BW27#function" } ] }, { "annotation": "Functions as a component of the nuclear pore complex (NPC).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RT08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RT08#function" }, { "database": "UniProtKB", "id": "RU365073", "url": "https://www.uniprot.org/uniprotkb/RU365073#function" }, { "database": "UniProtKB", "id": "A0AAA9S5H4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5H4#function" }, { "database": "UniProtKB", "id": "A0A3Q1MJA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJA8#function" }, { "database": "UniProtKB", "id": "A0AAA9TYD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYD3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], 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"https://www.reactome.org/PathwayBrowser/#R-BTA-4551638", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4570464", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4570464", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4615885", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4615885", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9615933", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9615933", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9648025", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029559", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJA8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJA8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RT08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RT08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RT08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RT08-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5H4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5H4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5H4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5H4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYD3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC98", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC98-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEFDGEPTVTWIPGVNSQKKQMCFDWGPGEMLVCETSFNKKEKSEMVAGCPFIHIIRKDIDVYSKILRKLFNESHGIFVGLQRIEEELTGKSRKAQLVRVSKNYRSVIRACMEEMHQFAVADKDSAIGRQFSSQVSILSAVELIWNLCEILFIEVAPAGPLLLYLLDWVRLHVCEVDSLSADVLGSENPSKHESFWNLVTTLVLQGRLDEARQMLSKEADSNPTSAGMCRVLGDLMRTMPILSPGNTQTLTELELRWQHWHEECERHLQDGTFASNPHLESLCKVLLGDDAALLEHKELLSNWYHFLVTRLLYSQPTVKPMDLHLYAQSSLDLFLGGESSPEPLDNILMAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYASGLFAHHSLWQLGVDYCDHCPELGRVSLELHIERIPLTTEQKALKVLRVCEQRQMTEQVRSICKVLAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLSDRLTFLGKYREFHRLYGEKCFVDAASLLLSLMTSQIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYELLRCLEDLTSGRPLCGEPDAQQLQDDDIETTKVEILRLALARNLARSIIKEGSLEGS", "length": 656, "header": "sp|Q3ZC98-1|NUP85_BOVIN Isoform 1 of Nuclear pore complex protein Nup85 OS=Bos taurus OX=9913 GN=NUP85 PE=2 SV=1 CANONICAL=Q3ZC98-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MJA8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98/entry#A0A3Q1MJA8-1", "sequence": { "sequence": "MAGGFFTPSVTSWIPGVNSQKKQMCFDWGPGEMLVCETSFNKKEKSEMVAGCPFIHIIRKDIDVYSKILRKLFNESHGIFVGLQRIEEELTGKSRKAQLVRVSKNYRSVIRACMEEMHQFAVADKDSAIGRQFSSQVSILSAVELIWNLCEILFIEVAPAGPLLLYLLDWVRLHVCEVDSLSADVLGSENPSKHESFWNLVTTLVLQGRLDEARQMLSKEADSNPTSAGMCRVLGDLMRTMPILSPGNTQTLTELELRWQHWHEECERHLQDGTFASNPHLESLCKVLLGDDAALLEHKELLSNWYHFLVTRLLYSQPTVKPMDLHLYAQSSLDLFLGGESSPEPLDNILMAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYASGLFAHHSLWQLGVDYCDHCPELGRVSLELHIERIPLTTEQKALKVLRVCEQRQMTEQVRSICKVLAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLSDRLTFLGKYREFHRLYGEKCFVDAASLLLSLMTSQIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYELLRCLEDLTSGRPLCGEPDAQQLQDDDIETTKVEILRLALARNLARSIIKEGSLEGS", "length": 657, "header": "tr|A0A3Q1MJA8-1|NUP85_BOVIN Computationally mapped isoform of Nuclear pore complex protein Nup85 OS=Bos taurus OX=9913 GN=NUP85 PE=2 SV=3 CANONICAL=Q3ZC98-1" }, "locus": { "chromosome": "19", "start_pos": 56264648, "end_pos": 56241182, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083920.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083920.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071419.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071419.2" } ] } }, { "isoform_ac": "A0AAA9RT08-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98/entry#A0AAA9RT08-1", "sequence": { "sequence": "MTNTGASASATVPRWIPGVNSQKKQMCFDWGPGEMLVCETSFNKKEKSEMVAGCPFIHIIRKDIDVYSKILRKLFNESHGIFVGLQRIEEELTGKSRKAQLVRVSKNYRSVIRACMEEMHQFAVADKDSAIGRQFSSQVSILSAVELIWNLCEILFIEVAPAGPLLLYLLDWVRLHVCEVDSLSADVLGSENPSKHESFWNLVTTLVLQGRLDEARQMLSKEADSNPTSAGMCRVLGDLMRTMPILSPGNTQTLTELELRWQHWHEECERHLQDGTFASNPHLESLCKVLLGDDAALLEHKELLSNWYHFLVTRLLYSQPTVKPMDLHLYAQSSLDLFLGGESSPEPLDNILMAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYASGLFAHHSLWQLGVDYCDHCPELGRVSLELHIERIPLTTEQKALKVLRVCEQRQMTEQVRSICKVLAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLSDRLTFLGKYREFHRLYGEKCFVDAASLLLSLMTSQIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYELLRCLEDLTSGRPLCGEPDAQQLQDDDIETTKVEILRLALARNLARSIIKEGSLEGS", "length": 659, "header": "tr|A0AAA9RT08-1|NUP85_BOVIN Computationally mapped isoform of Nuclear pore complex protein Nup85 OS=Bos taurus OX=9913 GN=NUP85 PE=2 SV=1 CANONICAL=Q3ZC98-1" }, "locus": { "chromosome": "19", "start_pos": 56268150, "end_pos": 56241182, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117669.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117669.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074877.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074877.1" } ] } }, { "isoform_ac": "A0AAA9S5H4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98/entry#A0AAA9S5H4-1", "sequence": { "sequence": "MEKAAAPTTRACRPRRGEETQWIPGVNSQKKQMCFDWGPGEMLVCETSFNKKEKSEMVAGCPFIHIIRKDIDVYSKILRKLFNESHGIFVGLQRIEEELTGKSRKAQLVRVSKNYRSVIRACMEEMHQFAVADKDSAIGRQFSSQVSILSAVELIWNLCEILFIEVAPAGPLLLYLLDWVRLHVCEVDSLSADVLGSENPSKHESFWNLVTTLVLQGRLDEARQMLSKEADSNPTSAGMCRVLGDLMRTMPILSPGNTQTLTELELRWQHWHEECERHLQDGTFASNPHLESLCKVLLGDDAALLEHKELLSNWYHFLVTRLLYSQPTVKPMDLHLYAQSSLDLFLGGESSPEPLDNILMAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYASGLFAHHSLWQLGVDYCDHCPELGRVSLELHIERIPLTTEQKALKVLRVCEQRQMTEQVRSICKVLAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLSDRLTFLGKYREFHRLYGEKCFVDAASLLLSLMTSQIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYELLRCLEDLTSGRPLCGEPDAQQLQDDDIETTKVEILRLALARNLARSIIKEGSLEGS", "length": 666, "header": "tr|A0AAA9S5H4-1|NUP85_BOVIN Computationally mapped isoform of Nuclear pore complex protein Nup85 OS=Bos taurus OX=9913 GN=NUP85 PE=2 SV=1 CANONICAL=Q3ZC98-1" }, "locus": { "chromosome": "19", "start_pos": 56269442, "end_pos": 56241182, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121601.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121601.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078482.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078482.1" } ] } }, { "isoform_ac": "A0AAA9TYD3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98/entry#A0AAA9TYD3-1", "sequence": { "sequence": "MEEFDGEPTVTWIPGVNSQKKQMCFDWGPGEMLVCETSFNKKEKSEMVAGCPFIHIIRKDIDVYSKILRKLFNESHGIFVGLQRIEEELTGKSRKAQLVRVSKNYRSVIRACMEEMHQFAVADKDSAIGRQFSSQVSILSAVELIWNLCEILFIEVAPAGPLLLYLLDWVRLHVCEVDSLSADVLGSENPSKHESFWNLPGNTQTLTELELRWQHWHEECERHLQDGTFASNPHLESLCKVLLGDDAALLEHKELLSNWYHFLVTRLLYSQPTVKPMDLHLYAQSSLDLFLGGESSPEPLDNILMAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYASGLFAHHSLWQLGVDYCDHCPELGRVSLELHIERIPLTTEQKALKVLRVCEQRQMTEQVRSICKVLAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLSDRLTFLGKYREFHRLYGEKCFVDAASLLLSLMTSQIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYELLRCLEDLTSGRPLCGEPDAQQLQDDDIETTKVEILRLALARNLARSIIKEGSLEGS", "length": 611, "header": "tr|A0AAA9TYD3-1|NUP85_BOVIN Computationally mapped isoform of Nuclear pore complex protein Nup85 OS=Bos taurus OX=9913 GN=NUP85 PE=2 SV=1 CANONICAL=Q3ZC98-1" }, "locus": { "chromosome": "19", "start_pos": 56268957, "end_pos": 56241182, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101567.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101567.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102516.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102516.1" } ] } }, { "isoform_ac": "Q3ZC98-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98/entry#Q3ZC98-1", "sequence": { "sequence": "MEEFDGEPTVTWIPGVNSQKKQMCFDWGPGEMLVCETSFNKKEKSEMVAGCPFIHIIRKDIDVYSKILRKLFNESHGIFVGLQRIEEELTGKSRKAQLVRVSKNYRSVIRACMEEMHQFAVADKDSAIGRQFSSQVSILSAVELIWNLCEILFIEVAPAGPLLLYLLDWVRLHVCEVDSLSADVLGSENPSKHESFWNLVTTLVLQGRLDEARQMLSKEADSNPTSAGMCRVLGDLMRTMPILSPGNTQTLTELELRWQHWHEECERHLQDGTFASNPHLESLCKVLLGDDAALLEHKELLSNWYHFLVTRLLYSQPTVKPMDLHLYAQSSLDLFLGGESSPEPLDNILMAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYASGLFAHHSLWQLGVDYCDHCPELGRVSLELHIERIPLTTEQKALKVLRVCEQRQMTEQVRSICKVLAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLSDRLTFLGKYREFHRLYGEKCFVDAASLLLSLMTSQIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYELLRCLEDLTSGRPLCGEPDAQQLQDDDIETTKVEILRLALARNLARSIIKEGSLEGS", "length": 656, "header": "sp|Q3ZC98-1|NUP85_BOVIN Isoform 1 of Nuclear pore complex protein Nup85 OS=Bos taurus OX=9913 GN=NUP85 PE=2 SV=1 CANONICAL=Q3ZC98-1" }, "locus": { "chromosome": "19", "start_pos": 56268957, "end_pos": 56241182, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034688.6", "url": "https://www.ensembl.org/id/ENSBTAT00000034688.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034574.4", "url": "https://www.ensembl.org/id/ENSBTAP00000034574.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC98", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:510540", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510540", "resource": "KEGG Pathway" }, { "id": "R-BTA-141430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "resource": "Reactome", "description": "Inactivation of APC/C via direct inhibition of the APC/C complex" }, { "id": "R-BTA-141444", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "resource": "Reactome", "description": "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" }, { "id": "R-BTA-159227", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159227", "resource": "Reactome", "description": "Transport of the SLBP independent Mature mRNA" }, { "id": "R-BTA-159230", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159230", "resource": "Reactome", "description": "Transport of the SLBP Dependant Mature mRNA" }, { "id": "R-BTA-159231", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159231", "resource": "Reactome", "description": "Transport of Mature mRNA Derived from an Intronless Transcript" }, { "id": "R-BTA-159236", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159236", "resource": "Reactome", "description": "Transport of Mature mRNA derived from an Intron-Containing Transcript" }, { "id": "R-BTA-1855170", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855170", "resource": "Reactome", "description": "IPs transport between nucleus and cytosol" }, { "id": "R-BTA-1855196", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855196", "resource": "Reactome", "description": "IP3 and IP4 transport between cytosol and nucleus" }, { "id": "R-BTA-1855229", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855229", "resource": "Reactome", "description": "IP6 and IP7 transport between cytosol and nucleus" }, { "id": "R-BTA-191859", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-191859", "resource": "Reactome", "description": "snRNP Assembly" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2500257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "resource": "Reactome", "description": "Resolution of Sister Chromatid Cohesion" }, { "id": "R-BTA-3108214", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3108214", "resource": "Reactome", "description": "SUMOylation of DNA damage response and repair proteins" }, { "id": "R-BTA-3232142", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3232142", "resource": "Reactome", "description": "SUMOylation of ubiquitinylation proteins" }, { "id": "R-BTA-3301854", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3301854", "resource": "Reactome", "description": "Nuclear Pore Complex (NPC) Disassembly" }, { "id": "R-BTA-3371453", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371453", "resource": "Reactome", "description": "Regulation of HSF1-mediated heat shock response" }, { "id": "R-BTA-4085377", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4085377", "resource": "Reactome", "description": "SUMOylation of SUMOylation proteins" }, { "id": "R-BTA-4551638", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4551638", "resource": "Reactome", "description": "SUMOylation of chromatin organization proteins" }, { "id": "R-BTA-4570464", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4570464", "resource": "Reactome", "description": "SUMOylation of RNA binding proteins" }, { "id": "R-BTA-4615885", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4615885", "resource": "Reactome", "description": "SUMOylation of DNA replication proteins" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" }, { "id": "R-BTA-9615933", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9615933", "resource": "Reactome", "description": "Postmitotic nuclear pore complex (NPC) reformation" }, { "id": "R-BTA-9648025", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "resource": "Reactome", "description": "EML4 and NUDC in mitotic spindle formation" } ], "orthologs": [ { "uniprot_canonical_ac": "A1YK02-1", "protein_name": "Nuclear pore complex protein Nup75", "gene_name": "Nup75", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSDSGVFAFELGDDLATRCGNTLTGVFVPGSRIALSAYRHVTHSSRDEPTENAGQVPVLIYMAQESTLFDEPVLRSVLAEANATFATLQQLGSRATRAEYVNISRAYRSIVRSCLEKLEQAKKSPEVQTDEARLQRLCDAIVVFYAAECLWHLFEILYIQSNQLVVPQLLDWARFHSPHAEDRATDLLLMGEEASESDDYWSIVKSLIMLGEIDVTRAVLSQNRKAGQTSFKAAEQILKSMPVYQEGYALQKFHSQWEFWHVDTERKIQSGLFATEPELEQLIRLVAGDSEQWDAGIKESQDFYEYLPGYLLFTKPTCKPFELKIAAAKWLNRWCLLRPEREQCSMNRMVSQLMDHDLRLFIYDAQKLNDTHWFSTHLIDLIHHCGQLKSYFDQNNIDLPALRHSMIYEYGSYLMTSHNMWQLGIDYLDCCKQEGQAAIELLLPRITLRSERQATKLINLARQRGLISVEREICKVLSKRSYDNERYGNALEWAIRSKDVLLVTAVADFILKHYSKTGCMLCPDTIANVGGRMFASPRLVFLSKYFEFYEFYRTRDFLSASELLVNLLESKITPDYFWPSLLIDSMPLLESKDPKIFAKETVAILHHIETDLVPIIERDVSKYGKHHTETVFKDYRVENVDEIMNLLRLACARNLARALIIENTLPVV", "length": 668 }, "evidence": [ { "id": "Q3ZC98", "url": "https://omabrowser.org/oma/group/Q3ZC98/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q4QQS8-1", "protein_name": "Nuclear pore complex protein Nup85", "gene_name": "Nup85", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEELDCEPAVTWIPGVNSKKKQMCFDWGPGEMLLCETSFNKTDKSEKVPSCPFIYIIRKDVDVYSQILRKLFNESHGIFVGLQRLEEELSGKSRKAQLVRVSKNYRSVIRACMEEMHQVAIAAKDPASGRQFSSQVSILSAMELIWNLCEILFIEVAPAGPLLLHLLDWVRLHVCEVDSLSADVLGSDHPSKHESFWNLVTVLVLQGRLDEARQMLSKEADASPSSAGMCRVLGDLMRTMPILSPGNTQTLTELELKWQHWREECERHLQDNTFAANPHLESLCKIMLGDEATLLEQKELMSNWYHFLVTRLLYSNPTVKPTDLHLYAQSSLDMFLGGESSPEPLDNILMAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCRLLQSHNLYFGSNMREFLLLEYASGLFAHHSLWQLGVDYFDYCPELGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVGSICKILAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLSDRLTFLGKYREFHRLYGEKRFGDAASLLLSLMTSQIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYELMRCLEDLASRRPECGEPDAQRLQDDDIETTKVEMLRLALARNLARAIIREGSLEGS", "length": 656 }, "evidence": [ { "id": "Q3ZC98", "url": "https://omabrowser.org/oma/group/Q3ZC98/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R480-1", "protein_name": "Nuclear pore complex protein Nup85", "gene_name": "Nup85", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEELDCEPAVTWIPGVNSKKKQMCFDWGPGEMLLCETSFNQTGKSEKVPSCPFIYIIRKDVDVYSQILRKLFNESHGIFVGLQKIEEELSGKSRKAQLVRVSKNYRSVIRACMEEMHQVAIAAKDPASGRQFSSQVSILSAMELIWNLCEILFIEVAPAGPLLLHLLDWVRLHVCEVDSLSADVLGGDNPSKHENFWDLVTVLVLQGRLDEARQMLAKEADANPSCAGMCRVLGDLMRTMPILSPGNTQTLTELELKWQHWREECERHLQDNTFAANPRLESLCKIMLGDEAALLEQKELLSNWYHFLVTRLLYSNPTVKPIDLHFYAQSSLDMFLGGESSPEPLDNILMAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCRLLQSHNLYFGSNMREFLLLEYASGLFAHHSLWQLGVDYFDYCPELGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVKSICKILAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGSAMMLSDRLTFLGKYREFHRLYGEKRFGDAASLLLSLMTSQIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYELMRCLEDLASGRPECGEPDAQRLQDDDIETTKVEMLRLALARNLARAIIREGSLEGS", "length": 656 }, "evidence": [ { "id": "Q3ZC98", "url": "https://omabrowser.org/oma/group/Q3ZC98/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8RXH2-1", "protein_name": "Nuclear pore complex protein NUP85", "gene_name": "NUP85", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MPGMSSESGGGELVLFSTKEKTPVLYPLSYGLKSPVHRLSISWGCGNNLRVTVLRNPELRDDDDGEVGGKVVNVRLSGEDGEISDPQWRRIAYGSVSPFALLQSRRNSISSLSKMDMSSSLYQTAWWEYVMEYSRDIKSLLSNTISLPAPLIEDPRSVIKNAEEPTSLKAAWELMELFYADKTCLSWLPERLVDWLSEYDILLSSSHPTIYSKLQDFQKELVGLQAIEDDPRYWEVMASALSVGWLEIVVKLLHLHGSYQLDQLGHRETENGLVEAVAVLISKMPRMRPQLEDGKFGECSAAKPDFMKTRERWQSQITKLECSAFWVQCAHHQTREGLRNMLKIMIGNADCLRAATCNWMELFVSHLLYLRPFTKGLDGMHSLAQKCVQSKPVNTSHKLLRLLIGILGENTEVVLAECSKEFGSWMVAHAMELLTAGSEEGEVLVHEEQRKLGGINMEELHRLVYAQVLSSHALTWQIAPIYLASCEKQGLGLLELLFYRQPVQENQMLIKSLEICRLYELSNVSAKLMKISGVHHWKHGRKGSGIFWLQQARDENCLSVIAQQLFDSVGKSLSDESLKQWEGLVELLGSESQISGGLDFLHKYRDFKRSLKVVHDGKTIDAAHEAVERLVSLMKSPSTPQRFWLPLLHDSLKLLNWPERSLLNVTQTNLMLNKLQELSIARLRPGFIESELSAQAVGSVRLALATNLGRAFLEEC", "length": 716 }, "evidence": [ { "id": "Q3ZC98", "url": "https://omabrowser.org/oma/group/Q3ZC98/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9BW27-1", "protein_name": "Nuclear pore complex protein Nup85", "gene_name": "NUP85", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEELDGEPTVTLIPGVNSKKNQMYFDWGPGEMLVCETSFNKKEKSEMVPSCPFIYIIRKDVDVYSQILRKLFNESHGIFLGLQRIDEELTGKSRKSQLVRVSKNYRSVIRACMEEMHQVAIAAKDPANGRQFSSQVSILSAMELIWNLCEILFIEVAPAGPLLLHLLDWVRLHVCEVDSLSADVLGSENPSKHDSFWNLVTILVLQGRLDEARQMLSKEADASPASAGICRIMGDLMRTMPILSPGNTQTLTELELKWQHWHEECERYLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWYHFLVTRLLYSNPTVKPIDLHYYAQSSLDLFLGGESSPEPLDNILLAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYASGLFAHPSLWQLGVDYFDYCPELGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLSDRLTFLGKYREFHRMYGEKRFADAASLLLSLMTSRIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYELMRCLEDLTSRRPVHGESDTEQLQDDDIETTKVEMLRLSLARNLARAIIREGSLEGS", "length": 656 }, "evidence": [ { "id": "Q3ZC98", "url": "https://omabrowser.org/oma/group/Q3ZC98/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "nephron development", "id": "GO:0072006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072006", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC98", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98" } ], "pmid": "" }, { "name": "mRNA export from nucleus", "id": "GO:0006406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006406", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC98", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC98", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98" } ], "pmid": "" }, { "name": "protein import into nucleus", "id": "GO:0006606", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006606", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC98", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC98", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98" } ], "pmid": "" }, { "name": "mRNA transport", "id": "GO:0051028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051028", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC98", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "nuclear pore outer ring", "id": "GO:0031080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031080", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC98", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC98", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98" } ], "pmid": "" }, { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC98", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC98", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC98", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98" } ], "pmid": "" }, { "name": "nuclear pore", "id": "GO:0005643", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005643", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC98", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC98", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC98", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of nuclear pore", "id": "GO:0017056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017056", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC98", "url": "https://www.uniprot.org/uniprotkb/Q3ZC98" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZC98-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 656, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZC98-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZC98" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 73, "end_pos": 75 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q95L54-1", "uniprot_ac": "Q95L54", "uniprot_id": "ANXA8_BOVIN", "mass": { "chemical_mass": 36787.0, "monoisotopic_mass": 36787.0 }, "refseq": { "ac": "NP_776666", "name": "annexin A8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776666" }, "gene_names": [ { "name": "ANXA8L1", "type": "recommended", "evidence": [ { "id": "Q95L54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95L54" } ] }, { "name": "ANXA8", "type": "recommended", "evidence": [ { "id": "Q95L54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95L54" } ] }, { "name": "ANXA8L1", "type": "synonym", "evidence": [ { "id": "NP_776666", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776666" } ] }, { "name": "ANXA8", "type": "synonym", "evidence": [ { "id": "NP_776666", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776666" } ] } ], "protein_names": [ { "name": "Annexin A8", "type": "recommended", "evidence": [ { "id": "Q95L54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95L54/entry#names_and_taxonomy" } ] }, { "name": "Annexin VIII", "type": "synonym", "evidence": [ { "id": "Q95L54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95L54/entry#names_and_taxonomy" } ] }, { "name": "Annexin-8", "type": "synonym", "evidence": [ { "id": "Q95L54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95L54/entry#names_and_taxonomy" } ] }, { "name": "annexin A8", "type": "synonym", "evidence": [ { "id": "NP_776666", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776666" } ] }, { "name": "annexin VIII", "type": "synonym", "evidence": [ { "id": "NP_776666", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776666" } ] }, { "name": "annexin-8", "type": "synonym", "evidence": [ { "id": "NP_776666", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776666" } ] } ], "function": [ { "annotation": "Annexin VIII was expressed by growth plate, not epiphyseal, chondrocytes. In osteoarthritic cartilage, it was seen in a subset of mid- to deep zone chondrocytes & the matrix around them; none was detected in normal articular cartilage.", "evidence": [ { "database": "RefSeq", "id": "NP_776666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776666" }, { "database": "PubMed", "id": "12369789", "url": "https://glygen.org/publication/PubMed/12369789" } ] }, { "annotation": "This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.", "evidence": [ { "database": "UniProtKB", "id": "Q95L54", "url": "https://www.uniprot.org/uniprotkb/Q95L54#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q95L54", "url": "https://www.uniprot.org/uniprotkb/Q95L54" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANXA8", "url": "https://www.uniprot.org/uniprotkb/Q95L54", "locus": {} } ], "crossref": [ { "id": "Q95L54", "url": "https://alphafold.ebi.ac.uk/entry/Q95L54", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018499", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018499", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "281627", "url": "https://www.ncbi.nlm.nih.gov/gene/281627", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009115", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009115", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037104", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037104", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281627", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281627", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CYVEHDV", "url": "https://omabrowser.org/oma/group/CYVEHDV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q95L54", "url": "https://www.orthodb.org/?gene=Q95L54", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10502", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10502", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10502:SF133", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10502:SF133", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00191", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00191", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_776666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776666", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTA5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTA5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTA5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGS6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAG1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAG1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAG1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAG1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q95L54", "url": "https://www.uniprot.org/uniprotkb/Q95L54", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q95L54-1", "url": "https://www.uniprot.org/uniprotkb/Q95L54-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAWWKAWVEQEGVSVKGSPHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNAQRQQIAKSFKAQFGKDLIETLKSELSGKFERLIIALMYPPYRYEAKELYDAMKGIGTKEGVIIEILASRTKNQLQEIMKAYEEDYGSNLEEDIKADTSGYLERILVCLLQGSRDDLSGYVDPGLALQDAQDLYAAGEKICGTDEMKFITILCTRSATHLMRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTRNLHGYFAERLYFAMKGAGTLDGTLIRNIVSRSEIDLNLIKNQFKKMYGKTLSSMIMEDTSGDYKNALLNLVGSDL", "length": 327, "header": "sp|Q95L54-1|ANXA8_BOVIN Isoform 1 of Annexin A8 OS=Bos taurus OX=9913 GN=ANXA8 PE=2 SV=1 CANONICAL=Q95L54-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MTA5-1", "url": "https://www.uniprot.org/uniprotkb/Q95L54/entry#A0A3Q1MTA5-1", "sequence": { "sequence": "MEAWILLQVEQEGVSVKGSPHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNAQRQQIAKSFKAQFGKDLIETLKSELSGKFERLIIALMYPPYRYEAKELYDAMKGIGTKEGVIIEILASRTKNQLQEIMKAYEEDYGSNLEEDIKADTSGYLERILVCLLQGSRDDLSGYVDPGLALQDAQDLYAAGEKICGTDEMKFITILCTRSATHLMRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTRNLHGYFAERLYFAMKGAGTLDGTLIRNIVSRSEIDLNLIKNQFKKMYGKTLSSMIMEDTSGDYKNALLNLVGSDL", "length": 328, "header": "tr|A0A3Q1MTA5-1|ANXA8_BOVIN Computationally mapped isoform of Annexin A8 OS=Bos taurus OX=9913 GN=ANXA8 PE=2 SV=1 CANONICAL=Q95L54-1" }, "locus": { "chromosome": "28", "start_pos": 41965179, "end_pos": 41954763, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068445.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068445.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073504.1", "url": "https://www.ensembl.org/id/ENSBTAP00000073504.1" } ] } }, { "isoform_ac": "A0AAA9SGS6-1", "url": "https://www.uniprot.org/uniprotkb/Q95L54/entry#A0AAA9SGS6-1", "sequence": { "sequence": "MAWWKAWVEQEGVSVKGSPHFNPDPDAETLYKAMKGIGYVSPLLGHHAAALSSPAPISPWGKWGCSCHAPAGTNEQAIIDVLTKRSNAQRQQIAKSFKAQFGKDLIETLKSELSGKFERLIIALMYPPYRYEAKELYDAMKGSRDDLSGYVDPGLALQDAQDLYAAGEKICGTDEMKFITILCTRSATHLMRVKCTRNLHGYFAERLYFAMKGAGTLDGTLIRNIVSRSEIDLNLIKNQFKKMYGKTLSSMIMEDTSGDYKNALLNLVGSDL", "length": 272, "header": "tr|A0AAA9SGS6-1|ANXA8_BOVIN Computationally mapped isoform of Annexin A8 OS=Bos taurus OX=9913 GN=ANXA8 PE=2 SV=1 CANONICAL=Q95L54-1" }, "locus": { "chromosome": "28", "start_pos": 41970115, "end_pos": 41954763, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099192.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099192.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085390.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085390.1" } ] } }, { "isoform_ac": "A0AAA9TAG1-1", "url": "https://www.uniprot.org/uniprotkb/Q95L54/entry#A0AAA9TAG1-1", "sequence": { "sequence": "MAWWKAWVEQEGVSVKGSPHFNPDPDAETLYKAMKGIGYVSPLLGHHAAALSSPAPISPWGKWGCSCHAPAGTNEQAIIDVLTKRSNAQRQQIAKSFKAQFGKDLIETLKSELSGKFERLIIALMYPPYRYEAKELYDAMKGIGTKEGVIIEILASRTKNQLQEIMKAYEEDYGSNLEEDIKADTSGYLERILVCLLQGSRDDLSGYVDPGLALQDAQDLYAAGEKICGTDEMKFITILCTRSATHLMRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTRNLHGYFAERLYFAMKGAGTLDGTLIRNIVSRSEIDLNLIKNQFKKMYGKTLSSMIMEDTSGDYKNALLNLVGSDL", "length": 361, "header": "tr|A0AAA9TAG1-1|ANXA8_BOVIN Computationally mapped isoform of Annexin A8 OS=Bos taurus OX=9913 GN=ANXA8 PE=2 SV=1 CANONICAL=Q95L54-1" }, "locus": { "chromosome": "28", "start_pos": 41970115, "end_pos": 41954763, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130572.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130572.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095684.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095684.1" } ] } }, { "isoform_ac": "A0AAA9TYH4-1", "url": "https://www.uniprot.org/uniprotkb/Q95L54/entry#A0AAA9TYH4-1", "sequence": { "sequence": "MAWWKAWDLIETLKSELSGKFERLIIALMYPPYRYEAKELYDAMKGIGTKEGVIIEILASRTKNQLQEIMKAYEEDYGSNLEEDIKADTSGYLERILVCLLQGSRDDLSGYVDPGLALQDAQDLYAAGEKICGTDEMKFITILCTRSATHLMRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTRNLHGYFAERLYFAMKGAGTLDGTLIRNIVSRSEIDLNLIKNQFKKMYGKTLSSMIMEDTSGDYKNALLNLVGSDL", "length": 265, "header": "tr|A0AAA9TYH4-1|ANXA8_BOVIN Computationally mapped isoform of Annexin A8 OS=Bos taurus OX=9913 GN=ANXA8 PE=2 SV=1 CANONICAL=Q95L54-1" }, "locus": { "chromosome": "28", "start_pos": 41970115, "end_pos": 41954763, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092429.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092429.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101740.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101740.1" } ] } }, { "isoform_ac": "Q95L54-1", "url": "https://www.uniprot.org/uniprotkb/Q95L54/entry#Q95L54-1", "sequence": { "sequence": "MAWWKAWVEQEGVSVKGSPHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNAQRQQIAKSFKAQFGKDLIETLKSELSGKFERLIIALMYPPYRYEAKELYDAMKGIGTKEGVIIEILASRTKNQLQEIMKAYEEDYGSNLEEDIKADTSGYLERILVCLLQGSRDDLSGYVDPGLALQDAQDLYAAGEKICGTDEMKFITILCTRSATHLMRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTRNLHGYFAERLYFAMKGAGTLDGTLIRNIVSRSEIDLNLIKNQFKKMYGKTLSSMIMEDTSGDYKNALLNLVGSDL", "length": 327, "header": "sp|Q95L54-1|ANXA8_BOVIN Isoform 1 of Annexin A8 OS=Bos taurus OX=9913 GN=ANXA8 PE=2 SV=1 CANONICAL=Q95L54-1" }, "locus": { "chromosome": "28", "start_pos": 41970115, "end_pos": 41954763, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046510.4", "url": "https://www.ensembl.org/id/ENSBTAT00000046510.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043804.2", "url": "https://www.ensembl.org/id/ENSBTAP00000043804.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Annexin VIII is differentially expressed by chondrocytes in the mammalian growth plate during endochondral ossification and in osteoarthritic cartilage.", "journal": "Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research", "date": "2002-10", "authors": "White Alicia H, Watson Rachel E B, Newman Bill, Freemont Anthony J, Wallis Gillian A", "evidence": [ { "database": "RefSeq", "id": "NP_776666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776666" } ], "reference": [ { "type": "PubMed", "id": "12369789", "url": "https://glygen.org/publication/PubMed/12369789" } ] }, { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q95L54", "url": "https://www.uniprot.org/uniprotkb/Q95L54" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:281627", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281627", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2M6L5-1", "protein_name": "Annexin", "gene_name": "LOC100773073", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAWWKAWVEQEGVTVKGSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNVQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYKYEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSNLEEDIQADTSGYLERILVCLLQGSRDDVSGFVDPGLALQDAQDLYAAGEKIHGTDEMKFITILCTRSATHLMRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTRNLHSYFAERLHYAMKGAGTRDGTLIRNIVSRSEIDLNLIKGQFQKMYGKTLSSMIMGDTSGDYKNALLNLVGSDP", "length": 327 }, "evidence": [ { "id": "Q95L54", "url": "https://omabrowser.org/oma/group/Q95L54/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0Z986-1", "protein_name": "Annexin", "gene_name": "ANXA8L1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAWWKAWSEEEGKPVIGVYSNFDPTPDAQTLYKAMKGLGTDEQAIIEVLTKRSNKQRQEIAKSFKAQFGKDLIDSLRSELSGNFERLIVALMYPPYKYEAKELYDAMKGVGTSEDVIIEILASRTKAQIKEIIKAYKEEYGSDLEHDIASETSGYFKQILVCLLQGERDNASLYVDTALARQDAETLFSAGEKIKGTDEIQFITILCKRSATHLLKVFEEYQKLAGKSIEDSIKSETKGSLEDAMLAIVRCTRNIRQYFAERLYHALKGAGTDDGTLIRVIVSRNEVDLNLIKDEFRRIAGQPLSSMIVDDTSGDYKTALLNLCGSD", "length": 327 }, "evidence": [ { "id": "Q95L54", "url": "https://omabrowser.org/oma/group/Q95L54/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SEN1-1", "protein_name": "Annexin", "gene_name": "ANXA8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAWWKAWIEQEGVSVKGSPHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNAQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIIALMYPPYKYEAKELHDAMEGLGTKEGVIIEILASRTKNQLQEIMKAYEEDYGSSLEEDIQADTSGYLERILVCLLQGSRDDLSGFVDPGLALQDAQDLYAAGEKIRGTDEMKFITILCTRSATHLMRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTRNLHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKGQFNKMYGKTLSSMIMEDTSGDYKNALLNLVGSDP", "length": 327 }, "evidence": [ { "id": "Q95L54", "url": "https://omabrowser.org/oma/group/Q95L54/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O35640-1", "protein_name": "Annexin A8", "gene_name": "Anxa8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAWWKAWVEQEGVSVKGSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNVQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYSYEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSTLEEDIQGDTSGYLERILVCLLQGSRDDVSGFVDPGLVLQDAQALHEAGEKIMGTDEMKFITILCTRSATHLMRVFEEYEKIANKCIEDSIKSETHGSLEEAMLTVVKCTRNVHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKGQFKKMYGKTLSSMIMADTSGYYKTALLNLVGTDL", "length": 327 }, "evidence": [ { "id": "Q95L54", "url": "https://omabrowser.org/oma/group/Q95L54/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P24639-1", "protein_name": "Annexin A7", "gene_name": "nxnA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSYPPNQGYPPQSNSPQPGQYGAPQQGYPPQQGYPPQQGYPPQQGYPPQQGYPPQQGYPPQQGYPPQQGYPPQQGYPPQQGYPPQQGYPPQQGYPPQQGYPPQQGYPPQQGYPPQQGYPPQGYPPQQGYPPVGVPVGVPVGFAPGMVVGYHQGYFVGTITHDCKHDAEVLRKAMKGIGTNESDLIKVLANRNWAEREQIKREFSAKYSKDLIQDIKSETSGNFEKCLVALLTEPAHFDVEQIHSACAGAGTNENTIIEILVTRSNVQMEYIKQIFKNKHGKSLKDRLESEASGDFKKLLEKLTEPRDESPVINPMQVSKDAEDLYKAGEGKIGTDEKEFIKILTSRSLPHIAAVASEYIKHHKKHSLIKAIDSEFSGSIKTGLIAIVTYALNPYGYFAEILNKSMKGAGTNDNKLIRTVVTQMHNMPQIKTAYSTLFKNSLAHDIQADCSGDFKKLLLDIIS", "length": 462 }, "evidence": [ { "id": "Q95L54", "url": "https://omabrowser.org/oma/group/Q95L54/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q4FZU6-1", "protein_name": "Annexin A8", "gene_name": "Anxa8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAWWKAWVEQEGVSVKGSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNVQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSTLEEDIQGDTSGYLERILVCLLQGCRDDVSGFVDPGLALQDAQDLHAAGEKILGTDEMKFITILCTRSATHLMRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTRNVHSYFAERLYYAMKGAGTLDGTLIRNIVSRSEIDLNLIKSQFQKMYGKTLSSMIMGDTSGYYKTALLNLVGTDL", "length": 327 }, "evidence": [ { "id": "Q95L54", "url": "https://omabrowser.org/oma/group/Q95L54/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5VT79-1", "protein_name": "Annexin A8-like protein 1", "gene_name": "ANXA8L1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAWWKAWIEQEGVTVKSSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCLLQGSRDDVSSFVDPALALQDAQDLYAAGEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSLVGSDP", "length": 327 }, "evidence": [ { "id": "Q95L54", "url": "https://omabrowser.org/oma/group/Q95L54/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q95L54", "url": "https://www.uniprot.org/uniprotkb/Q95L54" } ], "pmid": "" }, { "name": "sarcolemma", "id": "GO:0042383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383", "evidence": [ { "database": "UniProtKB", "id": "Q95L54", "url": "https://www.uniprot.org/uniprotkb/Q95L54" } ], "pmid": "" }, { "name": "vesicle membrane", "id": "GO:0012506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012506", "evidence": [ { "database": "UniProtKB", "id": "Q95L54", "url": "https://www.uniprot.org/uniprotkb/Q95L54" } ], "pmid": "" }, { "name": "chromaffin granule membrane", "id": "GO:0042584", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042584", "evidence": [ { "database": "UniProtKB", "id": "Q95L54", "url": "https://www.uniprot.org/uniprotkb/Q95L54" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q95L54", "url": "https://www.uniprot.org/uniprotkb/Q95L54" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "blood coagulation", "id": "GO:0007596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596", "evidence": [ { "database": "UniProtKB", "id": "Q95L54", "url": "https://www.uniprot.org/uniprotkb/Q95L54" } ], "pmid": "" }, { "name": "endosome organization", "id": "GO:0007032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007032", "evidence": [ { "database": "UniProtKB", "id": "Q95L54", "url": "https://www.uniprot.org/uniprotkb/Q95L54" } ], "pmid": "" }, { "name": "endosomal transport", "id": "GO:0016197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016197", "evidence": [ { "database": "UniProtKB", "id": "Q95L54", "url": "https://www.uniprot.org/uniprotkb/Q95L54" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q95L54", "url": "https://www.uniprot.org/uniprotkb/Q95L54" } ], "pmid": "" }, { "name": "calcium-dependent phospholipid binding", "id": "GO:0005544", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005544", "evidence": [ { "database": "UniProtKB", "id": "Q95L54", "url": "https://www.uniprot.org/uniprotkb/Q95L54" } ], "pmid": "" }, { "name": "phosphatidylserine binding", "id": "GO:0001786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001786", "evidence": [ { "database": "UniProtKB", "id": "Q95L54", "url": "https://www.uniprot.org/uniprotkb/Q95L54" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q95L54-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 327, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q95L54-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q95L54" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "A0AAA9TYH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYH4#function" }, { "id": "A0AAA9TYH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYH4" }, { "id": "PIRSR609115-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609115-1" } ], "binding_site_uniprot": 204, "amino_acid": "Ile", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 204, "end_pos": 204, "start_aa": "Ile", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TYH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYH4#function" }, { "id": "A0AAA9TYH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYH4" }, { "id": "PIRSR609115-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609115-1" } ], "binding_site_uniprot": 206, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 206, "end_pos": 206, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TYH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYH4#function" }, { "id": "A0AAA9TYH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYH4" }, { "id": "PIRSR609115-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR609115-1" } ], "binding_site_uniprot": 208, "amino_acid": "Arg", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 208, "end_pos": 208, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SGS6", "database": "UniProtKB", "url": 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"id": "IPR012721", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012721", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017998", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017998", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027410", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027410", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281047", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281047", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WGLKYAV", "url": "https://omabrowser.org/oma/group/WGLKYAV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MTL6", "url": "https://www.orthodb.org/?gene=A0A3Q1MTL6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZCI9", "url": "https://www.orthodb.org/?gene=Q3ZCI9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11353", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11353", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00003iyg", "url": "https://www.rcsb.org/structure/pdb_00003iyg", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00004b2t", "url": "https://www.rcsb.org/structure/pdb_00004b2t", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3IYG", "url": "https://www.rcsb.org/structure/3IYG", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4B2T", "url": "https://www.rcsb.org/structure/4B2T", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00118", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00118", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-390471", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390471", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5620922", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620922", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6814122", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814122", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001028781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028781", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MTL6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTL6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTL6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8S3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8S3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8S3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8S3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCI9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALHVPKAPGFAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRLGLSVSEVIEGYEIACKKAHEILPDLVCCSAKNLRDVDEVSSLLHTSVMSKQYGNEVFLAKLIAQACVSIFPDSGHFNVDNIRVCKILGSGVHSSSVLHGMVFKKETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKSAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGRVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLNPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDMLEAGVLDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKKDWDEDQND", "length": 548, "header": "sp|Q3ZCI9-1|TCPQ_BOVIN Isoform 1 of T-complex protein 1 subunit theta OS=Bos taurus OX=9913 GN=CCT8 PE=1 SV=3 CANONICAL=Q3ZCI9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MTL6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9/entry#A0A3Q1MTL6-1", "sequence": { "sequence": "MALHVPKAPGFAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRLGLSVSEVIEGYEIACKKAHEILPDLVCCSAKNLRDVDEVSSLLHTSVMSKQYGNEVFLAKLIAQACVSIFPDSGHFNVDNIRVCKILGSGVHSSSVLHGMVFKKETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKSAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGRVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLNPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDMLEAGVLDTYLGKYWAIKLATNAAVTVLRVDQIIMAKLAGGPKAPKPQGNWDKDGWQDESHI", "length": 553, "header": "tr|A0A3Q1MTL6-1|TCPQ_BOVIN Computationally mapped isoform of T-complex protein 1 subunit theta OS=Bos taurus OX=9913 GN=CCT8 PE=1 SV=2 CANONICAL=Q3ZCI9-1" }, "locus": { "chromosome": "1", "start_pos": 7127399, "end_pos": 7114280, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096559.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096559.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100399.2", "url": "https://www.ensembl.org/id/ENSBTAP00000100399.2" } ] } }, { "isoform_ac": "A0AAA9S8S3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9/entry#A0AAA9S8S3-1", "sequence": { "sequence": "MHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRLGLSVSEVIEGYEIACKKAHEILPDLVCCSAKNLRDVDEVSSLLHTSVMSKQYGNEVFLAKLIAQACVSIFPDSGHFNVDNIRVCKILGSGVHSSSVLHGMVFKKETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKSAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGRVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLNPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDMLEAGVLDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKKDWDEDQND", "length": 529, "header": "tr|A0AAA9S8S3-1|TCPQ_BOVIN Computationally mapped isoform of T-complex protein 1 subunit theta OS=Bos taurus OX=9913 GN=CCT8 PE=1 SV=2 CANONICAL=Q3ZCI9-1" }, "locus": { "chromosome": "1", "start_pos": 7127799, "end_pos": 7115635, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116027.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116027.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082444.2", "url": "https://www.ensembl.org/id/ENSBTAP00000082444.2" } ] } }, { "isoform_ac": "Q3ZCI9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9/entry#Q3ZCI9-1", "sequence": { "sequence": "MALHVPKAPGFAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRLGLSVSEVIEGYEIACKKAHEILPDLVCCSAKNLRDVDEVSSLLHTSVMSKQYGNEVFLAKLIAQACVSIFPDSGHFNVDNIRVCKILGSGVHSSSVLHGMVFKKETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKSAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGRVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLNPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDMLEAGVLDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKKDWDEDQND", "length": 548, "header": "sp|Q3ZCI9-1|TCPQ_BOVIN Isoform 1 of T-complex protein 1 subunit theta OS=Bos taurus OX=9913 GN=CCT8 PE=1 SV=3 CANONICAL=Q3ZCI9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 162, "end_pos": 162, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ], "site_lbl": "Ser162" }, { "start_pos": 23, "end_pos": 23, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ], "site_lbl": "Ser23" }, { "start_pos": 269, "end_pos": 269, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ], "site_lbl": "Ser269" }, { "start_pos": 30, "end_pos": 30, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ], "site_lbl": "Tyr30" }, { "start_pos": 317, "end_pos": 317, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ], "site_lbl": "Ser317" }, { "start_pos": 505, "end_pos": 505, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ], "site_lbl": "Tyr505" }, { "start_pos": 537, "end_pos": 537, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ], "site_lbl": "Ser537" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Association of CRISP2, CCT8, PEBP1 mRNA abundance in sperm and sire conception rate in Holstein bulls.", "journal": "Theriogenology", "date": "2011-08", "authors": "Arangasamy A, Kasimanickam V R, DeJarnette J M, Kasimanickam R K", "evidence": [ { "database": "RefSeq", "id": "NP_001028781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028781" } ], "reference": [ { "type": "PubMed", "id": "21529916", "url": "https://glygen.org/publication/PubMed/21529916" } ] } ], "pathway": [ { "id": "bta:281047", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281047", "resource": "KEGG Pathway" }, { "id": "R-BTA-390471", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390471", "resource": "Reactome", "description": "Association of TriC/CCT with target proteins during biosynthesis" }, { "id": "R-BTA-5620922", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620922", "resource": "Reactome", "description": "BBSome-mediated cargo-targeting to cilium" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-BTA-6814122", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814122", "resource": "Reactome", "description": "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YCQ1-1", "protein_name": "T-complex protein 1 subunit theta", "gene_name": "CCT8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MALHVPKAPGFAQMLKEGAKHYSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMLVMASHMQEQEVGDGTNFVLVFAGVLLELAEDLLRMGLSVSEVIEGYEKACKKALEILPDLVCCSAKNLRDVDEVASLLHTSVMSKQYGNESFLSKLIAQACVSILPDSGHFNVDNIRVCKIVGAGVSASSVLHGMVFKKETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKNAEELMNFSKGEENLMDLQVKAIADSGANVVVTGGKVADMALHYANKYNLMIVRLNSKWDLRRLCKTVGATALPRLTPPTLEEMGHCNSVYLSEVGDTQVVVFKHEKEDGAISTILIRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLDQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGFDIEAEAAAVKDMLEAGILDTYLGKYWGIKLATNAAVTVLRVDQIIMAKTAGGPKVPKQQGHWDKDDWRDEPEQ", "length": 553 }, "evidence": [ { "id": "Q3ZCI9", "url": "https://omabrowser.org/oma/group/Q3ZCI9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABB5UQR5-1", "protein_name": "T-complex protein 1 subunit theta", "gene_name": "CCT8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALHVPKAPGFAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPDLVCCSAKNLRDVDEVSSLLHTSVMSKQYGNEAFLAKLIAQACVSIFPDSGHFNVDNIRVCKILGSGVLSSVLHGMVFKKETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMEAQVKAIADTGANVVVTGGKVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFESIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDMLEAGVLDTYLGKYWAIKLATNAAVTVLRVDQIIMAKLAGGPKAPKPQGNWDKDGWQDESHI", "length": 552 }, "evidence": [ { "id": "Q3ZCI9", "url": "https://omabrowser.org/oma/group/Q3ZCI9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4ACB8-1", "protein_name": "T-complex protein 1 subunit theta", "gene_name": "Cct8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALHVPKAPGFAQMLKDGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINRLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVITGYEIACKKAHEILPDLVCCSAKNLRDVDEVSSLLRTSIMSKQYGSEEFLAKLISQACVSIFPDSGNFNVDNIRVCKILGSGVYSSSVLHGMVFKKETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIAGTGANVIVTGGKVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPKLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYSVHQEGNKNVGLDIEAEVPAVKDMLEASILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKKDWDDDQND", "length": 548 }, "evidence": [ { "id": "Q3ZCI9", "url": "https://omabrowser.org/oma/group/Q3ZCI9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P42932-1", "protein_name": "T-complex protein 1 subunit theta", "gene_name": "Cct8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALHVPKAPGFAQMLKDGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINRLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVISGYEIACKKAHEILPELVCCSAKNLRDVDEVSSLLRTSIMSKQYGSETFLAKLIAQACVSIFPDSGNFNVDNIRVCKILGSGIYSSSVLHGMVFKKETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIAGTGANVIVTGGKVADIALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPKLTPPVQEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYSVHQEGNKNVGLDIEAEVPAVKDMLEASILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKKDWDDDQND", "length": 548 }, "evidence": [ { "id": "Q3ZCI9", "url": "https://omabrowser.org/oma/group/Q3ZCI9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P47079-1", "protein_name": "T-complex protein 1 subunit theta", "gene_name": "CCT8", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMAKKAGGPRAPQGPRPGNWDQED", "length": 568 }, "evidence": [ { "id": "Q3ZCI9", "url": "https://omabrowser.org/oma/group/Q3ZCI9/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P50990-1", "protein_name": "T-complex protein 1 subunit theta", "gene_name": "CCT8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALHVPKAPGFAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSIMSKQYGNEVFLAKLIAQACVSIFPDSGHFNVDNIRVCKILGSGISSSSVLHGMVFKKETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDMLEAGILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKKDWDDDQND", "length": 548 }, "evidence": [ { "id": "Q3ZCI9", "url": "https://omabrowser.org/oma/group/Q3ZCI9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q552J0-1", "protein_name": "T-complex protein 1 subunit theta", "gene_name": "cct8", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLGLTDMLKDGAKHFAGKDEAILRNIDATKQLSEITRTSLGPNGMNKMIINHLEKLFVTNDAATIIRELDVIHPAAKMLVMAAQMQEQEMGDGTNYVVTLTGEFLQKAATLLEMGLHPSEIITGFEKAGAKLQEIIESMIVYNLKDITDKKEVTKCLKSAIASKQYGYEEFLSEIITNACLQVLPKKAVNFNIDNVRVTKIPGGGVTDTSVIKGFVIPMDAEGTIKRMEKAKIAVFTMGIDLGRTETTGKVLITNEDELLQFSKGEEDSIRETITAIANTGVKVIISGSTVSELALHYIERFKIMLVRIQSKFQLRRVCKAIGATPLVKLGAPIPEELGYCDEVLVEEIGSTKCCIFRQNKEESEISTIVVRGSTNNILDDIERAIDDGVNVFKGMCKDGRFLAGAGAFEIEASRKLQAFADATPGLSQYSIRQYAEAFEIIPRTLAETSGHDSSKAISNIYAAHTKGNTNYGLDIESGQPKSVLEMDVLDAFASKLFAIKLATNTANTVLRVDQIIMSKPAGGPKPPKMGPTDADD", "length": 537 }, "evidence": [ { "id": "Q3ZCI9", "url": "https://omabrowser.org/oma/group/Q3ZCI9/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q94K05-1", "protein_name": "T-complex protein 1 subunit theta", "gene_name": "CCT8", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVGMSMQPYGIQSMLKEGYRHLSGLDEAVIKNIEACKELSTITRTSLGPNGMNKMVINHLDKLFVTNDAATIVNELEIQHPAAKLLVLAAKAQQEEIGDGANLTISFAGELLQNAEELIRMGLHPSEIISGYTKAVSKAVEILEQLVETGSETMDVRNKDEVISRMRAAVASKQFGQEEIICSLVTDACIQVCPKNPTNFNVDNVRVSKLLGGGLHNSCIVRGMVLKSDAVGSIKRMEKAKVAVFAGGVDTTATETKGTVLIHSAEQLENYAKTEEAKVEELIKAVAESGAKVIVSGGSIGEMALHFCERYKIMVLKISSKFELRRFCRTAGAVAHLKLSRPSPEDLGYVDSISVEEIGGVTVTIARNEEGGNSISTVVLRGSTDSILDDLERAVDDGVNTYKAMCRDSRIVPGAAATEIELAQRLKEYANAEIGLDKYAITKYAESFEFVPKTLADNAGLNAMEIIAALYTGHGSGNTKLGIDLEEGACKDVSETKVWDLFATKLFALKYASDAACTVLRVDQIIMAKPAGGPRRDAAQAAGAGAEED", "length": 549 }, "evidence": [ { "id": "Q3ZCI9", "url": "https://omabrowser.org/oma/group/Q3ZCI9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ], "pmid": "" }, { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ], "pmid": "" }, { "name": "ATP-dependent protein folding chaperone", "id": "GO:0140662", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140662", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ], "pmid": "" }, { "name": "chaperonin-containing T-complex", "id": "GO:0005832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005832", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCI9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 267, "end_pos": 269, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] }, { "id": "R-BTA-391266", "name": "Association of CCT/TriC with sphingosine kinase 1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-391266", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-391266" } ] }, { "id": "R-BTA-5624125", "name": "Formation of the BBSome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBH0-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-5624125", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5624125" } ] }, { "id": "R-BTA-6798748", "name": "Exocytosis of secretory granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, secretory granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P19120-1", "P68401-1", "A0JNA3-1", "F1MMD5-1", "A0AAA9S4U4-1", "P80177-1", "Q0II59-1", "Q0VCM4-1", "Q3SWY3-1", "Q3SYU2-1", "F1MHT1-1", "A0AAA9RV00-1", "A0ABI0P3F2-1", "P62935-1", "P68103-1", "Q3T0Q4-1", "A0A452DJA8-1", "E1BNY9-1", "A0A3Q1LMV5-1", "A0A3Q1LTT9-1", "A1A4J1-1", "F1MQ78-1", "G3X757-1", "P00432-1", "Q76LV2-1", "A0A140T8A5-1", "A0A3Q1LR63-1", "Q56JW4-1", "Q3T0A3-1", "Q3ZBD7-1", "Q58DK5-1", "Q3SZ62-1", "Q3T0V9-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6798748", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798748" } ] }, { "id": "R-BTA-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, azurophil granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O77834-1", "Q29451-1", "P07514-1", "A0JNA3-1", "Q32PF2-1", "Q3MI05-1", "F1MUP9-1", "H7BWW2-1", "Q08DD1-1", "Q2KIM0-1", "Q3ZBH0-1", "F1MU24-1", "A0AAA9U1E9-1", "A0ABI0NJH4-1", "F1N144-1", "F1N5H2-1", "P80189-1", "P46196-1", "A7YWG4-1", "E1BPI3-1", "A0AAA9SWY4-1", "A0A3Q1LUG9-1", "F1MGY9-1", "G3X757-1", "A0A3Q1NDQ7-1", "Q2KJ64-1", "Q3ZCI9-1", "E1B725-1" ], "evidence": [ { "id": "R-BTA-6798751", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798751" } ] }, { "id": "R-BTA-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, ficolin-1-rich granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P19120-1", "P68401-1", "P80227-1", "A0JNA3-1", "F1MMD5-1", "Q32PF2-1", "Q3SZH7-1", "A0AAA9S4U4-1", "A0AAA9S9V5-1", "P07688-1", "O46414-1", "P25326-1", "P80177-1", "Q0VCM4-1", "Q3SWY3-1", "Q3SYU2-1", "F1MHT1-1", "F1MMR6-1", "A0ABI0NJH4-1", "A0AAA9RV00-1", "A0ABI0P3F2-1", "P05689-1", "P46196-1", "P52176-1", "P62935-1", "P68103-1", "Q17QB3-1", "Q3T0Q4-1", "Q27970-1", "A0A452DJA8-1", "E1BNY9-1", "A0A3Q1LMV5-1", "A0A3Q1LTT9-1", "A0AAA9SYX5-1", "A1A4J1-1", "E1BB52-1", "F1MQ78-1", "G3X757-1", "P00432-1", "Q76LV2-1", "A0A140T8A5-1", "A0A3Q1LR63-1", "A0A3Q1NDQ7-1", "Q3T0A3-1", "Q3ZBD7-1", "Q58DK5-1", "Q3SZ62-1", "Q3T0V9-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6800434", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6800434" } ] }, { "id": "R-BTA-6814119", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6814119", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814119" } ] }, { "id": "R-BTA-6814120", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6814120", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814120" } ] }, { "id": "R-BTA-6814121", "name": "PDCL binds G-protein beta and TRiC/CCT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6814121", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814121" } ] }, { "id": "R-BTA-6814124", "name": "ATP binds G-protein beta associated TRiC/CCT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6814124", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814124" } ] }, { "id": "R-BTA-8850527", "name": "PDCL releases folded G-beta from TRiC/CCT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-8850527", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8850527" } ] }, { "id": "R-BTA-8850529", "name": "RGS proteins bind GNB5 and CCT/TRiC", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-8850529", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8850529" } ] }, { "id": "R-BTA-8850534", "name": "PDCL promotes G-protein beta 5 folding", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-8850534", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8850534" } ] }, { "id": "R-BTA-8850539", "name": "Release of GNB5:RGS dimers from CCT/TRiC", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2NKZ1-1", "Q3ZBH0-1", "Q3MHL7-1", "Q3T0K2-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-8850539", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8850539" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T8A5", "gene_name": "IDH1", "activity": [ { "ec_number": "1.1.1.42", "activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] }, { "ec_number": "1.1.1.42", "activity": "", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] } ] }, { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LMV5", "gene_name": "LOC281806", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LR63", "gene_name": "HK3", "activity": [ { "ec_number": "2.7.1.1", "activity": "D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR63" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR63" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LTT9", "gene_name": "MAPK14", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LTT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT9" } ] } ] }, { "uniprot_ac": "A0A3Q1LUG9", "gene_name": "TXNDC5", "activity": [ { "ec_number": "5.3.4.1", "activity": "Catalyzes the rearrangement of -S-S- bonds in proteins.", "evidence": [ { "id": "A0A3Q1LUG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9" } ] }, { "ec_number": "5.3.4.1", "activity": "", "evidence": [ { "id": "A0A3Q1LUG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NDQ7", "gene_name": "GLB1", "activity": [ { "ec_number": "3.2.1.23", "activity": "Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.", "evidence": [ { "id": "A0A3Q1NDQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDQ7" } ] }, { "ec_number": "3.2.1.23", "activity": "", "evidence": [ { "id": "A0A3Q1NDQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDQ7" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0A452DJA8", "gene_name": "PNP", "activity": [ { "ec_number": "2.4.2.1", "activity": "adenosine + phosphate = alpha-D-ribose 1-phosphate + adenine.", "evidence": [ { "id": "A0A452DJA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DJA8" } ] }, { "ec_number": "2.4.2.1", "activity": "", "evidence": [ { "id": "A0A452DJA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DJA8" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", 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{ "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9S9V5", "gene_name": "CANT1", "activity": [ { "ec_number": "3.6.1.6", "activity": "a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ] }, { "ec_number": "3.6.1.6", "activity": "", "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SWY4", "gene_name": "CPPED1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": 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{ "ec_number": "3.1.6.4", "activity": "", "evidence": [ { "id": "A0AAA9U1E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1E9" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", 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units of heparan sulfate and keratan sulfate.", "evidence": [ { "id": "A0ABI0NJH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJH4" } ] }, { "ec_number": "3.1.6.14", "activity": "", "evidence": [ { "id": "A0ABI0NJH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJH4" } ] } ] }, { "uniprot_ac": "A0ABI0NSA6", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] } ] }, { "uniprot_ac": "A0ABI0NX25", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JNA3", "gene_name": "IMPDH1", "activity": [ { "ec_number": "1.1.1.205", "activity": "IMP + NAD(+) + H2O = XMP + NADH + H(+).", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A1A4J1", "gene_name": "PFKL", "activity": [ { "ec_number": "2.7.1.11", "activity": "beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+).", "evidence": [ { "id": "A1A4J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4J1" } ] }, { "ec_number": "2.7.1.11", "activity": "", "evidence": [ { "id": "A1A4J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4J1" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7YWG4", "gene_name": "GGH", "activity": [ { "ec_number": "3.4.19.9", "activity": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate.", "evidence": [ { "id": "A7YWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWG4" } ] }, { "ec_number": "3.4.19.9", "activity": "", "evidence": [ { "id": "A7YWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWG4" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B725", "gene_name": "GLA", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "E1B725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BNY9", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPI3", "gene_name": "FRK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MGY9", "gene_name": "AGA", "activity": [ { "ec_number": "3.5.1.26", "activity": "N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+).", "evidence": [ { "id": "F1MGY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGY9" } ] }, { "ec_number": "3.5.1.26", "activity": "", "evidence": [ { "id": "F1MGY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGY9" } ] } ] }, { "uniprot_ac": "F1MHT1", "gene_name": "AGL", "activity": [ { "ec_number": "2.4.1.25", "activity": "Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan.", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] }, { "ec_number": "3.2.1.33", "activity": "Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] }, { "ec_number": "3.2.1.33", "activity": "", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] }, { "ec_number": "2.4.1.25", "activity": "", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMR6", "gene_name": "CTSD", "activity": [ { "ec_number": "3.4.23.5", "activity": "Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.", "evidence": [ { "id": "F1MMR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMR6" } ] }, { "ec_number": "3.4.23.5", "activity": "", "evidence": [ { "id": "F1MMR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMR6" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MQ78", "gene_name": "ALOX5", "activity": [ { "ec_number": "1.13.11.34", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = leukotriene A4 + H2O.", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] }, { "ec_number": "1.13.11.12", "activity": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate.", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] }, { "ec_number": "1.13.11.34", "activity": "", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] }, { "ec_number": "1.13.11.12", "activity": "", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MU24", "gene_name": "PYGB", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "F1MU24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU24" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "F1MU24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU24" } ] } ] }, { "uniprot_ac": "F1MUP9", "gene_name": "VAT1", "activity": [ { "ec_number": "1.6.5.5", "activity": "2 1,2-naphthoquinone + NADPH + H(+) = 2 1,2-naphthosemiquinone + NADP(+).", "evidence": [ { "id": "F1MUP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUP9" } ] }, { "ec_number": "1.6.5.5", "activity": "", "evidence": [ { "id": "F1MUP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUP9" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N144", "gene_name": "ADA2", "activity": [ { "ec_number": "3.5.4.4", "activity": "2'-deoxyadenosine + H2O + H(+) = 2'-deoxyinosine + NH4(+).", "evidence": [ { "id": "F1N144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N144" } ] }, { "ec_number": "3.5.4.4", "activity": "", "evidence": [ { "id": "F1N144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N144" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F1N5H2", "gene_name": "FUCA2", "activity": [ { "ec_number": "3.2.1.51", "activity": "an alpha-L-fucoside + H2O = L-fucose + an alcohol.", "evidence": [ { "id": "F1N5H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5H2" } ] }, { "ec_number": "3.2.1.51", "activity": "", "evidence": [ { "id": "F1N5H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5H2" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "H7BWW2", "gene_name": "HEXB", "activity": [ { "ec_number": "3.2.1.52", "activity": "Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.", "evidence": [ { "id": "H7BWW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H7BWW2" } ] }, { "ec_number": "3.2.1.52", "activity": "", "evidence": [ { "id": "H7BWW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H7BWW2" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "O46414", "gene_name": "FTH1", "activity": [ { "ec_number": "1.16.3.1", "activity": "4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O.", "evidence": [ { "id": "O46414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46414" } ] }, { "ec_number": "1.16.3.1", "activity": "", "evidence": [ { "id": "O46414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46414" } ] } ] }, { "uniprot_ac": "O77834", "gene_name": "PRDX6", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "O77834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77834" } ] }, { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O77834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77834" } ] }, { "ec_number": "2.3.1.23", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA.", "evidence": [ { "id": "O77834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77834" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "O77834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77834" } ] } ] }, { "uniprot_ac": "P00432", "gene_name": "CAT", "activity": [ { "ec_number": "1.11.1.6", "activity": "2 H2O2 = O2 + 2 H2O.", "evidence": [ { "id": "P00432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00432" } ] }, { "ec_number": "1.11.1.6", "activity": "", "evidence": [ { "id": "P00432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00432" } ] } ] }, { "uniprot_ac": "P05689", "gene_name": "CTSZ", "activity": [ { "ec_number": "3.4.18.1", "activity": "Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.", "evidence": [ { "id": "P05689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05689" } ] }, { "ec_number": "3.4.18.1", "activity": "", "evidence": [ { "id": "P05689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05689" } ] } ] }, { "uniprot_ac": "P07514", "gene_name": "CYB5R3", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+).", "evidence": [ { "id": "P07514", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07514" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "P07514", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07514" } ] } ] }, { "uniprot_ac": "P07688", "gene_name": "CTSB", "activity": [ { "ec_number": "3.4.22.1", "activity": "Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.", "evidence": [ { "id": "P07688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07688" } ] }, { "ec_number": "3.4.22.1", "activity": "", "evidence": [ { "id": "P07688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07688" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P25326", "gene_name": "CTSS", "activity": [ { "ec_number": "3.4.22.27", "activity": "Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.", "evidence": [ { "id": "P25326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25326" } ] }, { "ec_number": "3.4.22.27", "activity": "", "evidence": [ { "id": "P25326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25326" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P52176", "gene_name": "MMP9", "activity": [ { "ec_number": "3.4.24.35", "activity": "Cleavage of gelatin types I and V and collagen types IV and V.", "evidence": [ { "id": "P52176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52176" } ] }, { "ec_number": "3.4.24.35", "activity": "", "evidence": [ { "id": "P52176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52176" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P62935", "gene_name": "PPIA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P62935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62935" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P62935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62935" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "P68401", "gene_name": "PAFAH1B2P68402", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P68401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68401" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "P68401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68401" } ] } ] }, { "uniprot_ac": "P80177", "gene_name": "MIF", "activity": [ { "ec_number": "5.3.2.1", "activity": "3-phenylpyruvate = enol-phenylpyruvate.", "evidence": [ { "id": "P80177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80177" } ] }, { "ec_number": "5.3.3.12", "activity": "L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.", "evidence": [ { "id": "P80177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80177" } ] }, { "ec_number": "5.3.2.1", "activity": "", "evidence": [ { "id": "P80177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80177" } ] }, { "ec_number": "5.3.3.12", "activity": "", "evidence": [ { "id": "P80177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80177" } ] } ] }, { "uniprot_ac": "P80189", "gene_name": "LYS", "activity": [ { "ec_number": "3.2.1.17", "activity": "Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.", "evidence": [ { "id": "P80189", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80189" } ] }, { "ec_number": "3.2.1.17", "activity": "", "evidence": [ { "id": "P80189", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80189" } ] } ] }, { "uniprot_ac": "P80227", "gene_name": "APEH", "activity": [ { "ec_number": "3.4.19.1", "activity": "Internal cleavage of oxidized and glycated proteins.", "evidence": [ { "id": "P80227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80227" } ] }, { "ec_number": "3.4.19.1", "activity": "", "evidence": [ { "id": "P80227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80227" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q08DD1", "gene_name": "ARSA", "activity": [ { "ec_number": "3.1.6.8", "activity": "an N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine + H2O = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + sulfate + H(+).", "evidence": [ { "id": "Q08DD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DD1" } ] }, { "ec_number": "3.1.6.8", "activity": "", "evidence": [ { "id": "Q08DD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DD1" } ] } ] }, { "uniprot_ac": "Q0II59", "gene_name": "PDXK", "activity": [ { "ec_number": "2.7.1.35", "activity": "pyridoxine + ATP = pyridoxine 5'-phosphate + ADP + H(+).", "evidence": [ { "id": "Q0II59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II59" } ] }, { "ec_number": "2.7.1.35", "activity": "", "evidence": [ { "id": "Q0II59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II59" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCM4", "gene_name": "PYGL", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "Q0VCM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCM4" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "Q0VCM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCM4" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q17QB3", "gene_name": "ASAH1", "activity": [ { "ec_number": "3.5.1.23", "activity": "an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid.", "evidence": [ { "id": "Q17QB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB3" } ] }, { "ec_number": "3.5.1.23", "activity": "", "evidence": [ { "id": "Q17QB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB3" } ] }, { "ec_number": "3.5.1.-", "activity": "", "evidence": [ { "id": "Q17QB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB3" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q27970", "gene_name": "CAPN1", "activity": [ { "ec_number": "3.4.22.52", "activity": "Broad endopeptidase specificity.", "evidence": [ { "id": "Q27970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27970" } ] }, { "ec_number": "3.4.22.52", "activity": "", "evidence": [ { "id": "Q27970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27970" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] } ] }, { "uniprot_ac": "Q29451", "gene_name": "MAN2B1", "activity": [ { "ec_number": "3.2.1.24", "activity": "Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.", "evidence": [ { "id": "Q29451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29451" } ] }, { "ec_number": "3.2.1.24", "activity": "", "evidence": [ { "id": "Q29451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29451" } ] } ] }, { "uniprot_ac": "Q29S22", "gene_name": "DDX47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2KIM0", "gene_name": "FUCA1", "activity": [ { "ec_number": "3.2.1.51", "activity": "an alpha-L-fucoside + H2O = L-fucose + an alcohol.", "evidence": [ { "id": "Q2KIM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIM0" } ] }, { "ec_number": "3.2.1.51", "activity": "", "evidence": [ { "id": "Q2KIM0", "database": "UniProtKB", "url": 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{ "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TBP1", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] } ] }, { "uniprot_ac": "Q2TBU9", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] } ] }, { "uniprot_ac": "Q32L40", "gene_name": "TCP1", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ] } ] }, { "uniprot_ac": "Q32LC7", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] } ] }, { "uniprot_ac": "Q32PF2", "gene_name": "ACLY", "activity": [ { "ec_number": "2.3.3.8", "activity": "oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA.", "evidence": [ { "id": "Q32PF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF2" } ] }, { "ec_number": "2.3.3.8", "activity": "", "evidence": [ { "id": "Q32PF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF2" } ] } ] }, { "uniprot_ac": "Q3B7N1", "gene_name": "CHD1L", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3B7N1", "database": 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"https://www.uniprot.org/uniprotkb/Q58D84/entry#names_and_taxonomy" } ] }, { "name": "follistatin-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001017950", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017950" } ] }, { "name": "follistatin-related protein 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001017950", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017950" } ] }, { "name": "follistatin-related protein 1", "type": "synonym", "evidence": [ { "id": "NP_001017950", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017950" } ] } ], "function": [ { "annotation": "Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (By similarity). Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter. Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity). Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q58D84", "url": "https://www.uniprot.org/uniprotkb/Q58D84#function" }, { "database": "UniProtKB", "id": "Q12841", "url": "https://www.uniprot.org/uniprotkb/Q12841#function" }, { "database": "UniProtKB", "id": "Q62356", "url": "https://www.uniprot.org/uniprotkb/Q62356#function" }, { "database": "UniProtKB", "id": "A0AAA9SBS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBS4#function" }, { "database": "UniProtKB", "id": "ARBA00045812", "url": "https://www.uniprot.org/uniprotkb/ARBA00045812#function" }, { "database": "UniProtKB", "id": "A0A3Q1MTZ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTZ0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": 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"https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16233", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534482", "url": "https://www.ncbi.nlm.nih.gov/gene/534482", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003645", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003645", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015369", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015369", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036773", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036773", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050653", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050653", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534482", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534482", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CIERCKP", "url": "https://omabrowser.org/oma/group/CIERCKP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MTZ0", "url": "https://www.orthodb.org/?gene=A0A3Q1MTZ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q58D84", "url": "https://www.orthodb.org/?gene=Q58D84", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10913", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10913", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10913:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10913:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07648", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07648", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09289", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09289", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23244", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23244", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23564", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23564", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-201451", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201451", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8957275", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001017950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017950", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTZ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTZ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTZ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTZ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBS4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D84", "url": "https://www.uniprot.org/uniprotkb/Q58D84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D84-1", "url": "https://www.uniprot.org/uniprotkb/Q58D84-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMWRRWLALALVAVAWVHAEEQVRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKGSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAINITTYADQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQTQAEEEMTRYVQELQKHQETAEKSKRVSTKEI", "length": 307, "header": "sp|Q58D84-1|FSTL1_BOVIN Isoform 1 of Follistatin-related protein 1 OS=Bos taurus OX=9913 GN=FSTL1 PE=2 SV=1 CANONICAL=Q58D84-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MTZ0-1", "url": "https://www.uniprot.org/uniprotkb/Q58D84/entry#A0A3Q1MTZ0-1", "sequence": { "sequence": "FIVSPWIALELLEDKDCAFISPEQVRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKGKWFLTAQPTPFPAVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKGSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAINITTYADQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQTQAEEEMTRYVQELQKHQVSCWFR", "length": 304, "header": "tr|A0A3Q1MTZ0-1|FSTL1_BOVIN Computationally mapped isoform of Follistatin-related protein 1 OS=Bos taurus OX=9913 GN=FSTL1 PE=2 SV=2 CANONICAL=Q58D84-1" }, "locus": { "chromosome": "1", "start_pos": 65156781, "end_pos": 65144709, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072624.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072624.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073919.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073919.2" } ] } }, { "isoform_ac": "A0AAA9SBS4-1", "url": "https://www.uniprot.org/uniprotkb/Q58D84/entry#A0AAA9SBS4-1", "sequence": { "sequence": "MWRRWLALALVAVAWVHAEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKGSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAINITTYADQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQTQAEEEMTRYVQELQKHQETAEKSKRVSTKEI", "length": 271, "header": "tr|A0AAA9SBS4-1|FSTL1_BOVIN Computationally mapped isoform of Follistatin-related protein 1 OS=Bos taurus OX=9913 GN=FSTL1 PE=2 SV=1 CANONICAL=Q58D84-1" }, "locus": { "chromosome": "1", "start_pos": 65198072, "end_pos": 65141109, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125201.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125201.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082842.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082842.1" } ] } }, { "isoform_ac": "Q58D84-1", "url": "https://www.uniprot.org/uniprotkb/Q58D84/entry#Q58D84-1", "sequence": { "sequence": "MMWRRWLALALVAVAWVHAEEQVRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKGSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAINITTYADQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQTQAEEEMTRYVQELQKHQETAEKSKRVSTKEI", "length": 307, "header": "sp|Q58D84-1|FSTL1_BOVIN Isoform 1 of Follistatin-related protein 1 OS=Bos taurus OX=9913 GN=FSTL1 PE=2 SV=1 CANONICAL=Q58D84-1" }, "locus": { "chromosome": "1", "start_pos": 65198236, "end_pos": 65141109, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029891.4", "url": "https://www.ensembl.org/id/ENSBTAT00000029891.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029886.3", "url": "https://www.ensembl.org/id/ENSBTAP00000029886.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 143, "start_aa": "Asn", "end_pos": 143, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn143", "evidence": [ { "id": "Q58D84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D84#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 174, "start_aa": "Asn", "end_pos": 174, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn174", "evidence": [ { "id": "Q58D84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D84#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 179, "start_aa": "Asn", "end_pos": 179, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn179", "evidence": [ { "id": "Q58D84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D84#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 164, "end_pos": 164, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58D84", "url": "https://www.uniprot.org/uniprotkb/Q58D84" } ], "site_lbl": "Ser164" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58D84", "url": "https://www.uniprot.org/uniprotkb/Q58D84" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:534482", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534482", "resource": "KEGG Pathway" }, { "id": "R-BTA-201451", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201451", "resource": "Reactome", "description": "Signaling by BMP" }, { "id": "R-BTA-381426", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "resource": "Reactome", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" }, { "id": "R-BTA-8957275", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "resource": "Reactome", "description": "Post-translational protein phosphorylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BP22-1", "protein_name": "Follistatin-related protein 1", "gene_name": "FSTL1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMWTRWLALALVAVAWVHAEEEPRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKGSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGTQTQTEEEMTRYVQELQKHQETAEKTKRVSTKEI", "length": 307 }, "evidence": [ { "id": "Q58D84", "url": "https://omabrowser.org/oma/group/Q58D84/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q12841-1", "protein_name": "Follistatin-related protein 1", "gene_name": "FSTL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWKRWLALALALVAVAWVRAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKGSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQTQTEEEMTRYVQELQKHQETAEKTKRVSTKEI", "length": 308 }, "evidence": [ { "id": "Q58D84", "url": "https://omabrowser.org/oma/group/Q58D84/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q62356-1", "protein_name": "Follistatin-related protein 1", "gene_name": "Fstl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWKRWLALSLVTIALVHGEEEPRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSASPSASPVVCYQANRDELRRRLIQWLEAEIIPDGWFSKGSNYSEILDKYFKSFDNGDSHLDSSEFLKFVEQNETAINITTYADQENNKLLRSLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCSCGHWVCTAMTCDGKNQKGVQTHTEEEKTGYVQELQKHQGTAEKTKKVNTKEI", "length": 306 }, "evidence": [ { "id": "Q58D84", "url": "https://omabrowser.org/oma/group/Q58D84/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q58D84", "url": "https://www.uniprot.org/uniprotkb/Q58D84" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "Q58D84", "url": "https://www.uniprot.org/uniprotkb/Q58D84" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q58D84", "url": "https://www.uniprot.org/uniprotkb/Q58D84" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q58D84", "url": "https://www.uniprot.org/uniprotkb/Q58D84" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "Q58D84", "url": "https://www.uniprot.org/uniprotkb/Q58D84" } ], "pmid": "" }, { "name": "endothelial cell migration", "id": "GO:0043542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043542", "evidence": [ { "database": "UniProtKB", "id": "Q58D84", "url": "https://www.uniprot.org/uniprotkb/Q58D84" } ], "pmid": "" }, { "name": "regulation of BMP signaling pathway", "id": "GO:0030510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030510", "evidence": [ { "database": "UniProtKB", "id": "Q58D84", "url": "https://www.uniprot.org/uniprotkb/Q58D84" } ], "pmid": "" }, { "name": "endothelial cell differentiation", "id": "GO:0045446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045446", "evidence": [ { "database": "UniProtKB", "id": "Q58D84", "url": "https://www.uniprot.org/uniprotkb/Q58D84" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 143, "end_pos": 145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 174, "end_pos": 176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58D84-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 307, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58D84-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58D84" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58D84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D84" }, { "id": "PRU00448", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00448" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand 1", "eco_id": "ECO_0000255", "start_pos": 143, "end_pos": 177, "start_aa": "Asn", "end_aa": "Ala", "glycosite_overlap": "Asn174,Asn143" }, { "evidence": [ { "id": "Q58D84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D84" }, { "id": "PRU00448", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00448" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand 2", "eco_id": "ECO_0000255", "start_pos": 192, "end_pos": 227, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58D84", "database": "UniProtKB", "url": 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"count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 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"table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q56JU9-1", "uniprot_ac": "Q56JU9", "uniprot_id": "RS24_BOVIN", "mass": { "chemical_mass": 15197.0, "monoisotopic_mass": 15197.0 }, "refseq": { "ac": "NP_001020510", "name": "small ribosomal subunit protein eS24", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020510" }, "gene_names": [ { "name": "RPS24", "type": "recommended", "evidence": [ { "id": "Q56JU9", "database": "UniProtKB", 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the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.", "evidence": [ { "database": "UniProtKB", "id": "Q56JU9", "url": "https://www.uniprot.org/uniprotkb/Q56JU9#function" }, { "database": "UniProtKB", "id": "P62847", "url": "https://www.uniprot.org/uniprotkb/P62847#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q56JU9", "url": "https://www.uniprot.org/uniprotkb/Q56JU9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPS24", "url": "https://www.uniprot.org/uniprotkb/Q56JU9", "locus": { "chromosome": "28", "start_pos": 33731624, "end_pos": 33725422, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013264", "url": "https://www.ensembl.org/id/ENSBTAG00000013264" } ] } } ], "crossref": [ { "id": "Q56JU9", "url": "https://alphafold.ebi.ac.uk/entry/Q56JU9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013264", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013264", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "530464", "url": "https://www.ncbi.nlm.nih.gov/gene/530464", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001976", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001976", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012678", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012678", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053709", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530464", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530464", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IRVKKYM", "url": "https://omabrowser.org/oma/group/IRVKKYM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q56JU9", "url": "https://www.orthodb.org/?gene=Q56JU9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10496", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10496", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01282", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01282", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001020510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020510", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1N3Q0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3Q0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N3Q0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3Q0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NDD3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NDD3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDD3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NMC5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMC5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NMC5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMC5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2R1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2R1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2R1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2R1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JU9", "url": "https://www.uniprot.org/uniprotkb/Q56JU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JU9-1", "url": "https://www.uniprot.org/uniprotkb/Q56JU9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JU9-2", "url": "https://www.uniprot.org/uniprotkb/Q56JU9-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVGAGKKK", "length": 131, "header": "sp|Q56JU9-1|RS24_BOVIN Isoform 1 of Small ribosomal subunit protein eS24 OS=Bos taurus OX=9913 GN=RPS24 PE=2 SV=2 CANONICAL=Q56JU9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N3Q0-1", "url": "https://www.uniprot.org/uniprotkb/Q56JU9/entry#A0A3Q1N3Q0-1", "sequence": { "sequence": "MNDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVGAGKKKE", "length": 132, "header": "tr|A0A3Q1N3Q0-1|RS24_BOVIN Computationally mapped isoform of Small ribosomal subunit protein eS24 OS=Bos taurus OX=9913 GN=RPS24 PE=2 SV=2 CANONICAL=Q56JU9-1" }, "locus": { "chromosome": "28", "start_pos": 33730620, "end_pos": 33725461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074310.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074310.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064217.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064217.2" } ] } }, { "isoform_ac": "A0A3Q1NDD3-1", "url": "https://www.uniprot.org/uniprotkb/Q56JU9/entry#A0A3Q1NDD3-1", "sequence": { "sequence": "MNDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVGAGKKKK", "length": 132, "header": "tr|A0A3Q1NDD3-1|RS24_BOVIN Computationally mapped isoform of Small ribosomal subunit protein eS24 OS=Bos taurus OX=9913 GN=RPS24 PE=2 SV=2 CANONICAL=Q56JU9-1" }, "locus": { "chromosome": "28", "start_pos": 33728667, "end_pos": 33725461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071428.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071428.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069494.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069494.2" } ] } }, { "isoform_ac": "A0A3Q1NMC5-1", "url": "https://www.uniprot.org/uniprotkb/Q56JU9/entry#A0A3Q1NMC5-1", "sequence": { "sequence": "MNDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVGAGKKKVTCFEKPLSWRLDNRRSKDSAVTVSVVIVQIFHERENKLRPFTCLAVWSIFEVSWECCKLVCYLTELNSPRSHVALSIQ", "length": 210, "header": "tr|A0A3Q1NMC5-1|RS24_BOVIN Computationally mapped isoform of Small ribosomal subunit protein eS24 OS=Bos taurus OX=9913 GN=RPS24 PE=2 SV=2 CANONICAL=Q56JU9-1" }, "locus": { "chromosome": "28", "start_pos": 33730807, "end_pos": 33725461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079785.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079785.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073735.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073735.2" } ] } }, { "isoform_ac": "A0ABI0P2R1-1", "url": "https://www.uniprot.org/uniprotkb/Q56JU9/entry#A0ABI0P2R1-1", "sequence": { "sequence": "MKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVGAGKKV", "length": 122, "header": "tr|A0ABI0P2R1-1|A0ABI0P2R1_BOVIN Computationally mapped isoform of 40S ribosomal protein S24 OS=Bos taurus OX=9913 GN=RPS24 PE=3 SV=1 CANONICAL=Q56JU9-1" }, "locus": { "chromosome": "28", "start_pos": 33728042, "end_pos": 33726874, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145655.1", "url": 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"https://www.uniprot.org/uniprotkb/Q56JU9/entry#Q56JU9-2", "sequence": { "sequence": "MNDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVGAGKK", "length": 130, "header": "sp|Q56JU9-2|RS24_BOVIN Isoform 2 of Small ribosomal subunit protein eS24 OS=Bos taurus OX=9913 GN=RPS24 PE=2 SV=2 CANONICAL=Q56JU9-1" }, "locus": { "chromosome": "28", "start_pos": 33728039, "end_pos": 33725461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046662.2", "url": "https://www.ensembl.org/id/ENSBTAT00000046662.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043937.1", "url": "https://www.ensembl.org/id/ENSBTAP00000043937.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 9, "end_pos": 9, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q56JU9", "url": 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"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZLU2-1", "protein_name": "40S ribosomal protein S24", "gene_name": "RPS24", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVGAGKKNNLVFLPFLLPVLLDNRRNEVSSSNWMYFRWKMDNNRLHNSIKKYGKNCSGKKLFI", "length": 186 }, "evidence": [ { "id": "Q56JU9", "url": "https://omabrowser.org/oma/group/Q56JU9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P0CX31-1", "protein_name": "Small ribosomal subunit protein eS24A", "gene_name": "RPS24A", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSDAVTIRTRKVISNPLLARKQFVVDVLHPNRANVSKDELREKLAEVYKAEKDAVSVFGFRTQFGGGKSVGFGLVYNSVAEAKKFEPTYRLVRYGLAEKVEKASRQQRKQKKNRDKKIFGTGKRLAKKVARRNAD", "length": 135 }, "evidence": [ { "id": "Q56JU9", "url": "https://omabrowser.org/oma/group/Q56JU9/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P0CX32-1", "protein_name": "Small ribosomal subunit protein eS24B", 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activator 28 subunit beta", "type": "synonym", "evidence": [ { "id": "NP_001014889", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014889" } ] }, { "name": "proteasome activator complex subunit 2", "type": "synonym", "evidence": [ { "id": "NP_001014889", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014889" } ] } ], "function": [ { "annotation": "Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1N568", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N568#function" }, { "database": "UniProtKB", "id": "ARBA00037467", "url": "https://www.uniprot.org/uniprotkb/ARBA00037467#function" }, { "database": "UniProtKB", "id": "Q5E9G3", "url": "https://www.uniprot.org/uniprotkb/Q5E9G3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9G3", "url": "https://www.uniprot.org/uniprotkb/Q5E9G3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSME2", "url": "https://www.uniprot.org/uniprotkb/Q5E9G3", "locus": { "chromosome": "10", "start_pos": 21007790, "end_pos": 21004530, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005814", "url": "https://www.ensembl.org/id/ENSBTAG00000005814" } ] } } ], "crossref": [ { "id": "Q5E9G3", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9G3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005814", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005814", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "509857", "url": "https://www.ncbi.nlm.nih.gov/gene/509857", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009077", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009077", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036996", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036996", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036997", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036997", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509857", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509857", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KKPPKCG", "url": "https://omabrowser.org/oma/group/KKPPKCG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N568", "url": "https://www.orthodb.org/?gene=A0A3Q1N568", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5E9G3", "url": "https://www.orthodb.org/?gene=Q5E9G3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10660", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10660", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10660:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10660:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02251", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02251", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02252", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02252", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1236974", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1236974", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1236978", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1236978", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9907900", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9907900", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9912633", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9912633", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001014889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014889", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1N568", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N568", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N568-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N568-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9G3", "url": "https://www.uniprot.org/uniprotkb/Q5E9G3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9G3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9G3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKPCGVRLSGEALKQVDVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSFNVTDLNSLRAPLDIPIPDPPPKDDEMETDKQEKKEVPKCGFLPGNEKVLALLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASKETHVMDYRALVHERDEAVYGDLRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY", "length": 239, "header": "sp|Q5E9G3-1|PSME2_BOVIN Isoform 1 of Proteasome activator complex subunit 2 OS=Bos taurus OX=9913 GN=PSME2 PE=1 SV=3 CANONICAL=Q5E9G3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N568-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9G3/entry#A0A3Q1N568-1", "sequence": { "sequence": "LSVQVDVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSFNVTDLNSLRAPLDIPIPDPPPKDDEMETDKQEKKEKEEEVAREREMALPKCGFLPGNEKVLALLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASKETHVMDYRALVHERDEAVYGDLRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY", "length": 239, "header": "tr|A0A3Q1N568-1|PSME2_BOVIN Computationally mapped isoform of Proteasome activator complex subunit 2 OS=Bos taurus OX=9913 GN=PSME2 PE=1 SV=2 CANONICAL=Q5E9G3-1" }, "locus": { "chromosome": "10", "start_pos": 21007744, "end_pos": 21004950, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077746.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077746.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065215.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065215.2" } ] } }, { "isoform_ac": "Q5E9G3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9G3/entry#Q5E9G3-1", "sequence": { "sequence": "MAKPCGVRLSGEALKQVDVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSFNVTDLNSLRAPLDIPIPDPPPKDDEMETDKQEKKEVPKCGFLPGNEKVLALLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASKETHVMDYRALVHERDEAVYGDLRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY", "length": 239, "header": "sp|Q5E9G3-1|PSME2_BOVIN Isoform 1 of Proteasome activator complex subunit 2 OS=Bos taurus OX=9913 GN=PSME2 PE=1 SV=3 CANONICAL=Q5E9G3-1" }, "locus": { "chromosome": "10", "start_pos": 21007744, "end_pos": 21004601, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007642.3", "url": "https://www.ensembl.org/id/ENSBTAT00000007642.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007642.1", "url": "https://www.ensembl.org/id/ENSBTAP00000007642.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 10, "end_pos": 10, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G3", "url": "https://www.uniprot.org/uniprotkb/Q5E9G3" } ], "site_lbl": "Ser10" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G3", "url": "https://www.uniprot.org/uniprotkb/Q5E9G3" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "PA28, an activator of the 20 S proteasome, is composed of two nonidentical but homologous subunits.", "journal": "J. Biol. Chem.", "date": "1994", "authors": "Mott J D, Pramanik B C, Moomaw C R, Afendis S J, DeMartino G N, Slaughter C A", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G3", "url": "https://www.uniprot.org/uniprotkb/Q5E9G3" } ], "reference": [ { "type": "PubMed", "id": "7989312", "url": "https://glygen.org/publication/PubMed/7989312" } ] } ], "pathway": [ { "id": "bta:509857", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509857", "resource": "KEGG Pathway" }, { "id": "R-BTA-1236974", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1236974", "resource": "Reactome", "description": "ER-Phagosome pathway" }, { "id": "R-BTA-1236978", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1236978", "resource": "Reactome", "description": "Cross-presentation of soluble exogenous antigens (endosomes)" }, { "id": "R-BTA-9907900", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9907900", "resource": "Reactome", "description": "Proteasome assembly" }, { "id": "R-BTA-9912633", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9912633", "resource": "Reactome", "description": "Antigen processing: Ub, ATP-independent proteasomal degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "G3HDE3-1", "protein_name": "Proteasome activator complex subunit 2", "gene_name": "Psme2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAKPCGVRLSGEARKQVDVFRQNLFQEADDFLSTFLPRKIISLSQLLQEDFLNVADLSSLRAPLDIPIPDPPPKDDEMETDKQEKKEVPKCGFLPGNEKLLALFAVVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVRDLRAFYAELYHIISNNLEKIVNPKGEEKPSMY", "length": 239 }, "evidence": [ { "id": "Q5E9G3", "url": "https://omabrowser.org/oma/group/Q5E9G3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P97372-1", "protein_name": "Proteasome activator complex subunit 2", "gene_name": "Psme2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKPCGVRLSGEARKQVDVFRQNLFQEADDFLCTFLPRKIISLSQLLQEDSLNVADLSSLRAPLDIPIPDPPPKDDEMETDKQEKKEVPKCGYLPGNEKLLALLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASKDTHVMDYRALVHERDEAAYGALRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY", "length": 239 }, "evidence": [ { "id": "Q5E9G3", "url": "https://omabrowser.org/oma/group/Q5E9G3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q63798-1", "protein_name": "Proteasome activator complex subunit 2", "gene_name": "Psme2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAKPCGVRLSGEARKQVDAFRQNLFQEAEDFLCTFLPRKIISLSQLLQEDSLNVADLSSLRAPLDIPIPDPPPKDDEMETEQEKKEVPKCGFLPGNEKLLALLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTAISKYFSERGDAVAKASKDTHVMDYRALVHERDEAAYGALRAMVLDLRAFYAELHHIISSNLEKIVNPKGEEKPSMY", "length": 238 }, "evidence": [ { "id": "Q5E9G3", "url": "https://omabrowser.org/oma/group/Q5E9G3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9UL46-1", "protein_name": "Proteasome activator complex subunit 2", "gene_name": "PSME2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSLRAPLDIPIPDPPPKDDEMETDKQEKKEVHKCGFLPGNEKVLSLLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY", "length": 239 }, "evidence": [ { "id": "Q5E9G3", "url": "https://omabrowser.org/oma/group/Q5E9G3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G3", "url": 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"uniprot_id": "STX7_BOVIN", "mass": { "chemical_mass": 29656.0, "monoisotopic_mass": 29656.0 }, "refseq": { "ac": "NP_001071332", "name": "syntaxin-7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071332" }, "gene_names": [ { "name": "STX7", "type": "recommended", "evidence": [ { "id": "Q3ZBT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ] }, { "name": "STX7", "type": "synonym", "evidence": [ { "id": "NP_001071332", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071332" } ] } ], "protein_names": [ { "name": "Syntaxin-7", "type": "recommended", "evidence": [ { "id": "Q3ZBT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5/entry#names_and_taxonomy" } ] }, { "name": "syntaxin-7", "type": "synonym", "evidence": [ { "id": "NP_001071332", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071332" } ] } ], "function": [ { "annotation": "May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NGJ6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NGJ6#function" }, { "database": "UniProtKB", "id": "ARBA00037599", "url": "https://www.uniprot.org/uniprotkb/ARBA00037599#function" }, { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STX7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5", "locus": { "chromosome": "9", "start_pos": 70392456, "end_pos": 70449105, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017139", "url": "https://www.ensembl.org/id/ENSBTAG00000017139" } ] } } ], "crossref": [ { "id": "Q3ZBT5", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBT5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017139", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017139", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00179", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00179", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15875", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15875", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507031", "url": "https://www.ncbi.nlm.nih.gov/gene/507031", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000727", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000727", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045242", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045242", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507031", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507031", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LMTYTKQ", "url": "https://omabrowser.org/oma/group/LMTYTKQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NGJ6", "url": "https://www.orthodb.org/?gene=A0A3Q1NGJ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBT5", "url": "https://www.orthodb.org/?gene=Q3ZBT5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19957", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19957", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19957:SF90", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19957:SF90", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05739", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05739", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14523", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14523", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071332", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NGJ6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NGJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NGJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NGJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBT5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSYTPGVGGDPAQLAQRISSNIQKITQCSAEIQRTLNQLGTPQDSPELRQQLQQKQQYTNQLAKETDKYIKEFGSLPTTPSDQRQRKIQKDRLVAEFTASLTNFQKVQRQAAEREKEFVARVRASSRVSGGFPEESSKERNLVSWESQTQPQAQLQDEEITEDDLRLIQERESSIRQLEADIMDINEIFKDLGMMIHEQGDVIDSIEANVENAEVHVQQANQQLSRAADYQRKSRKTLCIIIFILVIGVVIIGLIIWGVKG", "length": 261, "header": "sp|Q3ZBT5-1|STX7_BOVIN Isoform 1 of Syntaxin-7 OS=Bos taurus OX=9913 GN=STX7 PE=2 SV=1 CANONICAL=Q3ZBT5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NGJ6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5/entry#A0A3Q1NGJ6-1", "sequence": { "sequence": "MSYTPGVGGDPAQLAQRISSNIQKITQCSAEIQRTLNQLGTPQDSPELRQQLQQKQQYTNQLAKETDKYIKEFGSLPTTPSDQRQRKIQKDRLVAEFTASLTNFQKVQRQAAEREKEFVARVRASSRVSGGFPEESSKERNLVSWESQTQPQAQLQDEEITEDDLRLIQERESSIRQLEADIMDINEIFKDLGMMIHEQGDVIDSIEANVENAEVHVQQANQQLSRAADYQKKDSWMLL", "length": 239, "header": "tr|A0A3Q1NGJ6-1|STX7_BOVIN Computationally mapped isoform of Syntaxin-7 OS=Bos taurus OX=9913 GN=STX7 PE=2 SV=2 CANONICAL=Q3ZBT5-1" }, "locus": { "chromosome": "9", "start_pos": 70439175, "end_pos": 70394421, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084405.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084405.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070937.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070937.2" } ] } }, { "isoform_ac": "Q3ZBT5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5/entry#Q3ZBT5-1", "sequence": { "sequence": "MSYTPGVGGDPAQLAQRISSNIQKITQCSAEIQRTLNQLGTPQDSPELRQQLQQKQQYTNQLAKETDKYIKEFGSLPTTPSDQRQRKIQKDRLVAEFTASLTNFQKVQRQAAEREKEFVARVRASSRVSGGFPEESSKERNLVSWESQTQPQAQLQDEEITEDDLRLIQERESSIRQLEADIMDINEIFKDLGMMIHEQGDVIDSIEANVENAEVHVQQANQQLSRAADYQRKSRKTLCIIIFILVIGVVIIGLIIWGVKG", "length": 261, "header": "sp|Q3ZBT5-1|STX7_BOVIN Isoform 1 of Syntaxin-7 OS=Bos taurus OX=9913 GN=STX7 PE=2 SV=1 CANONICAL=Q3ZBT5-1" }, "locus": { "chromosome": "9", "start_pos": 70439175, "end_pos": 70393724, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022780.5", "url": "https://www.ensembl.org/id/ENSBTAT00000022780.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022780.3", "url": "https://www.ensembl.org/id/ENSBTAP00000022780.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 125, "end_pos": 125, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", 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"", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "site_lbl": "Ser45" }, { "start_pos": 4, "end_pos": 4, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "site_lbl": "Thr4" }, { "start_pos": 75, "end_pos": 75, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "site_lbl": "Ser75" }, { "start_pos": 79, "end_pos": 79, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "site_lbl": "Thr79" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507031", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507031", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QD51-1", "protein_name": "Syntaxin-7", "gene_name": "STX7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSYTPGIGGDPAQLAQCISSNIQKITQCSVEIQRTLNQLGTPQDTPELRQQLQQKQQYTNQLAKETDKYIKEFGSLPTTPSEQRQRKIQKDRLVAEFTTSLTNFQKVQRQAAEKEKEFVARVRASSRVSGGFPEETSKERNLVSWESQTQPQVQVQDEEITEDDLRLIHERESSIRQLEADIMDINEIFKDLGMMIHEQGDVIDSIEANVESSEVHVQQANQQLSRAADYQRKSRKTLCIIIFILVIGVVIIGFIIWRVKS", "length": 261 }, "evidence": [ { "id": "Q3ZBT5", "url": "https://omabrowser.org/oma/group/Q3ZBT5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O15400-1", "protein_name": "Syntaxin-7", "gene_name": "STX7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSYTPGVGGDPAQLAQRISSNIQKITQCSVEIQRTLNQLGTPQDSPELRQQLQQKQQYTNQLAKETDKYIKEFGSLPTTPSEQRQRKIQKDRLVAEFTTSLTNFQKVQRQAAEREKEFVARVRASSRVSGSFPEDSSKERNLVSWESQTQPQVQVQDEEITEDDLRLIHERESSIRQLEADIMDINEIFKDLGMMIHEQGDVIDSIEANVENAEVHVQQANQQLSRAADYQRKSRKTLCIIILILVIGVAIISLIIWGLNH", "length": 261 }, "evidence": [ { "id": "Q3ZBT5", "url": "https://omabrowser.org/oma/group/Q3ZBT5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O70257-1", "protein_name": "Syntaxin-7", "gene_name": "Stx7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSYTPGIGGDPAQLAQRISSNIQKITQCSAEIQRTLNQLGTPQDTPELRQQLQQEQQYTNQLAKETDKYIKEFGFLPTTPSEQRQRKIQKDRLVAEFTTALTNFQKVQRQAAEREKEFVARVRASSRVSGGFPEDSSKEKNFVSWESQTQPQVQVQDEEITEDDLRLIHERESSIRQLEADIMDINEIFKDLGMMIHEQGDVIDSIEANVESAEVHVQQANQQLSRAANYQRKSRKTLCIIILILVVGIVIIFFIVWGLKG", "length": 261 }, "evidence": [ { "id": "Q3ZBT5", "url": "https://omabrowser.org/oma/group/Q3ZBT5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O70439-1", "protein_name": "Syntaxin-7", "gene_name": "Stx7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSYTPGIGGDSAQLAQRISSNIQKITQCSVEIQRTLNQLGTPQDSPELRQLLQQKQQYTNQLAKETDKYIKEFGSLPTTPSEQRQRKIQKDRLVAEFTTSLTNFQKAQRQAAEREKEFVARVRASSRVSGGFPEDSSKEKNLVSWESQTQPQVQVQDEEITEDDLRLIHERESSIRQLEADIMDINEIFKDLGMMIHEQGDMIDSIEANVESAEVHVQQANQQLSRAADYQRKSRKTLCIIIFILVVRIVIICLIVWGLKG", "length": 261 }, "evidence": [ { "id": "Q3ZBT5", "url": "https://omabrowser.org/oma/group/Q3ZBT5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P93654-1", "protein_name": "Syntaxin-22", "gene_name": "SYP22", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSFQDLESGRGRSTRKFNGGRQDSTQAVASGIFQINTGVSTFQRLVNTLGTPKDTPELREKLHKTRLHIGQLVKDTSAKLKEASETDHQSGVNPSKKIADAKLARDFQAVLKEFQKAQQTAAERETTYTPFVPQSALPSSYTAGEVDKVPEQRAQLQESKRQELVLLDNEIAFNEAVIEEREQGIQEIHQQIGEVNEIFKDLAVLVNDQGVMIDDIGTHIDNSRAATSQGKSQLVQAAKTQKSNSSLTCLLLVIFGIVLLIVIIVLAA", "length": 268 }, "evidence": [ { "id": "Q3ZBT5", "url": "https://omabrowser.org/oma/group/Q3ZBT5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q54JY7-1", "protein_name": "Syntaxin-7A", "gene_name": "syn7A", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MYNNNNNFGGGGYNQGGGYNSGGYNNNGGGYNNNNGGYNNNNNNNGGYNNNRPQQQQQQQQQYVNNNNNSFDNNGYGGDDDVTNNSDYQSTTRNIQQIQNAVQILTKLVQLLGTPKDSMDTREKIRNCVDSTTHLISSESGKVKNLTSLASRSRDSKNKLLYQKLVKEFNNCLQQFKDIAQVATKKEKTTPLPVAPDHQQPTTFGRNNNSNNNNQNNHFLNNQQPYYDDDNREDEHQSLMESSRRQQLAQIEAEREYQNSIIQERDEGIRKIEQSIVEINEIFVDLSGLVAEQGVMINTIEASLESTTINTKEGVNHLREASKNQKSSRNKMCWIVLILLIVCAVLGVILFFTLRK", "length": 356 }, "evidence": [ { "id": "Q3ZBT5", "url": "https://omabrowser.org/oma/group/Q3ZBT5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "chloride channel inhibitor activity", "id": "GO:0019869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019869", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" }, { "name": "syntaxin binding", "id": "GO:0019905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019905", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" }, { "name": "SNARE binding", "id": "GO:0000149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000149", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" }, { "name": "SNAP receptor activity", "id": "GO:0005484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005484", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" }, { "name": "positive regulation of T cell mediated cytotoxicity", "id": "GO:0001916", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001916", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" }, { "name": "regulation of protein localization to plasma membrane", "id": "GO:1903076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903076", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" }, { "name": "positive regulation of receptor localization to synapse", "id": "GO:1902685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902685", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" }, { "name": "vesicle fusion", "id": "GO:0006906", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006906", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" }, { "name": "vesicle docking", "id": "GO:0048278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048278", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 11, "go_terms": [ { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" }, { "name": "recycling endosome", "id": "GO:0055037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" }, { "name": "tertiary granule", "id": "GO:0070820", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070820", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" }, { "name": "endocytic vesicle", "id": "GO:0030139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030139", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" }, { "name": "azurophil granule", "id": "GO:0042582", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042582", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" }, { "name": "synaptic vesicle", "id": "GO:0008021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" }, { "name": "SNARE complex", "id": "GO:0031201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031201", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" }, { "name": "immunological synapse", "id": "GO:0001772", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001772", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBT5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 261, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBT5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBT5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZBT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT5" }, { "id": "PRU00202", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00202" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "t-SNARE coiled-coil homology", "eco_id": "ECO_0000255", "start_pos": 165, "end_pos": 227, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 4, 45, 75, 79, 125, 126, 129, 205 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 8 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZC82-1", "uniprot_ac": "Q3ZC82", "uniprot_id": "ZC3HE_BOVIN", "mass": { "chemical_mass": 82023.0, "monoisotopic_mass": 82023.0 }, "refseq": { "ac": "NP_001029578", "name": "zinc finger CCCH domain-containing protein 14 isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029578" }, "gene_names": [ { "name": "ZC3H14", "type": "recommended", "evidence": [ { "id": "Q3ZC82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82" } ] }, { "name": "ZC3H14", "type": "synonym", "evidence": [ { "id": "NP_001029578", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029578" } ] } ], "protein_names": [ { "name": "Zinc finger CCCH domain-containing protein 14", "type": "recommended", "evidence": [ { "id": "Q3ZC82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82/entry#names_and_taxonomy" } ] }, { "name": "zinc finger CCCH domain-containing protein 14 isoform 2", "type": "synonym", "evidence": [ { "id": "NP_001029578", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029578" } ] }, { "name": "zinc finger CCCH domain-containing protein 14", "type": "synonym", "evidence": [ { "id": "NP_001029578", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029578" } ] } ], "function": [ { "annotation": "RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs. Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome. Required for spermatogenesis via involvement in circRNA biogenesis. Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation. Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NMZ1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMZ1#function" }, { "database": "UniProtKB", "id": "ARBA00059881", "url": "https://www.uniprot.org/uniprotkb/ARBA00059881#function" }, { "database": "UniProtKB", "id": "F1N567", "url": "https://www.uniprot.org/uniprotkb/F1N567#function" }, { "database": "UniProtKB", "id": "A0AAA9TH13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH13#function" }, { "database": "UniProtKB", "id": "Q3ZC82", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82#function" }, { "database": "UniProtKB", "id": "Q6PJT7", "url": "https://www.uniprot.org/uniprotkb/Q6PJT7#function" }, { "database": "UniProtKB", "id": "F1N565", "url": "https://www.uniprot.org/uniprotkb/F1N565#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZC82", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZC3H14", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82", "locus": { "chromosome": "10", "start_pos": 100300816, "end_pos": 100258222, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030453", "url": "https://www.ensembl.org/id/ENSBTAG00000030453" } ] } } ], "crossref": [ { "id": "Q3ZC82", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZC82", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030453", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030453", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511473", "url": "https://www.ncbi.nlm.nih.gov/gene/511473", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000571", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000571", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040366", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040366", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511473", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511473", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CPYTHVS", "url": "https://omabrowser.org/oma/group/CPYTHVS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NMZ1", "url": "https://www.orthodb.org/?gene=A0A3Q1NMZ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N565", "url": "https://www.orthodb.org/?gene=F1N565", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N567", "url": "https://www.orthodb.org/?gene=F1N567", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZC82", "url": "https://www.orthodb.org/?gene=Q3ZC82", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14738", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14738", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14738:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14738:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14608", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14608", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029578", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NMZ1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NMZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH13", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH13-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH13-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N565", "url": "https://www.uniprot.org/uniprotkb/F1N565", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N565-1", "url": "https://www.uniprot.org/uniprotkb/F1N565-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N567", "url": "https://www.uniprot.org/uniprotkb/F1N567", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N567-1", "url": "https://www.uniprot.org/uniprotkb/F1N567-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC82", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC82-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC82-2", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEIGTEISRKIRSAIKGKLQELGAYVDEELPDYIMVMVANKKSQDQMTEDLSLFLGNNTIRFTVWLHGVLDKLRSVTTDPASLKSSDTNLFDGNVPSNKSSFSRGDERRHEAAVPPLAVSSTRPEKRESRVSTSSQEQKATNVRQTYDDGAATRLMSTVKPLRELAPSEDVIDIKPEPDDLIDEDLNFVQENPLSQKKTTVTLTYGSSRPSIEIYRPPATRNTDSGAHLNRLQFQQQQNSIHAAKQLDIQSSRVYETGRLCEPEVLNSLEETYSPFFRSNAEKMSIEEENFRKRKLPVVSSVVKVKKFSHDGEEEEEDDDCGSRTGSISSSVSVPAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVSQKQTLPVAPRTRTSQEDLLAEVAQGHGRVPRISSPVKEEEAQGGSVDERQGTQQRQLLSRLQIDPVMAETLQISQDYYDMESMVHADTRSFILKKPKLCEELVVAASQASGMETADALQARSGHLVQTRDLVQPDKPASPKFIVTLDGVPSPPGYMSDQEEDMCSEGMRPAQHPAASHGGLAGLLHPQRSRVLSRQLEDPDGSFANAEMSELSVAQKPEKLLERCKYWPACKNGDECAYHHPVSPCKAFPNCKFAEKCLFVHPNCKYDAKCTKPDCPFTHMSRRTPGLPPKPVTAPAPPSSSQLCRYFPACKKMECPFYHPKHCRFNTQCTRPDCAFYHPTITVPPRHALKWIRPQTSD", "length": 735, "header": "sp|Q3ZC82-1|ZC3HE_BOVIN Isoform 1 of Zinc finger CCCH domain-containing protein 14 OS=Bos taurus OX=9913 GN=ZC3H14 PE=2 SV=2 CANONICAL=Q3ZC82-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NMZ1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82/entry#A0A3Q1NMZ1-1", "sequence": { "sequence": "MEIGTEISRKIRSAIKGKLQELGAYVDEELPDYIMVMVANKKSQDQMTEDLSLFLGNNTIRFTVWLHGVLDKLRSVTTDPASLKSSDTNLFDGNVPSNKSSFSRGDERRHEAAVPPLAVSSTRPEKRESRVSTSSQEQKATNVRQTYDDGAATRLMSTVKPLRELAPSEDVIDIKPEPDDLIDEDLNFVQENPLSQKKTTVTLTYGSSRPSIEIYRPPATRNTDSGAHLNRLQFQQQQNSIHAAKQLDIQSSRVYETGRLCEPEVLNSLEETYSPFFRSNAEKMSIEEENFRKRKLPVVSSVVKVKKFSHDGEEEEEDDDCGSRTGSISSSVSVPAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVSQKQTLPVAPRTRTSQEDLLAEVAQGHGRVPRISSPVKEEEAQGGSVDERQDTRSFILKKPKLCEELVVAASQASGMETADALQARSGHLVQTRDLVQPDKPASPKFIVTLDGVPSPPGYMSDQEEDMCSEGMRPAQHPAASHGGLAGLLHPQRSRVLSRQLEDPDGSFANAEMSELSVAQKPEKLLERCKYWPACKNGDECAYHHPVSPCKAFPNCKFAEKCLFVHPNCKYDAKCTKPDCPFTHMSRRTPGLPPKPVTAPAPPSSSQLCRYFPACKKMECPFYHPKHCRFNTQCTRPDCAFYHPTITVPPRHALKWIRPQTSD", "length": 699, "header": "tr|A0A3Q1NMZ1-1|ZC3HE_BOVIN Computationally mapped isoform of Zinc finger CCCH domain-containing protein 14 OS=Bos taurus OX=9913 GN=ZC3H14 PE=2 SV=3 CANONICAL=Q3ZC82-1" }, "locus": { "chromosome": "10", "start_pos": 100299552, "end_pos": 100258280, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071203.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071203.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074037.3", "url": "https://www.ensembl.org/id/ENSBTAP00000074037.3" } ] } }, { "isoform_ac": "A0AAA9TH13-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82/entry#A0AAA9TH13-1", "sequence": { "sequence": "MKMSSRFPSPSLPIFFSPGPVDLGSVTSSSCSLNELDSISHLLRKISTDINEIKGMKAAVLTVEANLFDLNVRVSQNEAKISSLEVKMNEYSTSEGSRQFEDLQEEVDFASQSRTTDVKIIGFLRNIEKGTQQRQLLSRLQIDPVMAETLQISQAEMSELSVAQKPEKLLERCKYWPACKNGDECAYHHPVSPCKAFPNCKFAEKCLFVHPNCKYDAKCTKPDCPFTHMSRRTPGLPPKPVTAPAPPSSSQLCRYFPACKKMECPFYHPKHCRFNTQCTRPDCAFYHPTITVPPRHALKWIRPQTSD", "length": 307, "header": "tr|A0AAA9TH13-1|ZC3HE_BOVIN Computationally mapped isoform of Zinc finger CCCH domain-containing protein 14 OS=Bos taurus OX=9913 GN=ZC3H14 PE=2 SV=2 CANONICAL=Q3ZC82-1" }, "locus": { "chromosome": "10", "start_pos": 100299552, "end_pos": 100283332, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088742.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088742.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096160.2", "url": "https://www.ensembl.org/id/ENSBTAP00000096160.2" } ] } }, { "isoform_ac": "F1N565-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82/entry#F1N565-1", "sequence": { "sequence": "MEIGTEISRKIRSAIKGKLQELGAYVDEELPDYIMVMVANKKSQDQMTEDLSLFLGNNTIRFTVWLHGVLDKLRSVTTDPASLKSSDTNLFDGNVPSNKSSFSRGDERRHEAAVPPLAVSSTRPEKRESRVSTSSQEQKATNVRQTYDDGAATRLMSTVKPLRELAPSEDVIDIKPEPDDLIDEDLNFVQENPLSQKKTTVTLTYGSSRPSIEIYRPPATRNTDSGAHLNRLQFQQQQNSIHAAKQLDIQSSRVYETGRLCEPEVLNSLEETYSPFFRSNAEKMSIEEENFRKRKLPVVSSVVKVKKFSHDGEEEEEDDDCGSRTGSISSSVSVPAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVSQKQTLPVAPRTRTSQEDLLAEVAQGHGRVPRISSPVKEEEAQGGSVDERQGTQQRQLLSRLQIDPVMAETLQISQAHIGTSHGLPQDRGEHLIYVWWDRCWKLWFLDYSVSTPTEFSSPVFRTPQSTTIFPYPSWPAQKDYYDMESMVHADTRSFILKKPKLCEELVVAASQASGMETADALQARSGHLVQTRDLVQPDKPASPKFIVTLDGVPSPPGYMSDQEEDMCSEGMRPAQHPAASHGGLAGLLHPQRSRVLSRQLEDPDGSFANAEMSELSVAQKPEKLLERCKYWPACKNGDECAYHHPVSPCKAFPNCKFAEKCLFVHPNCKYDAKCTKPDCPFTHMSRRTPGLPPKPVTAPAPPSSSQLCRYFPACKKMECPFYHPKHCRFNTQCTRPDCAFYHPTITVPPRHALKWIRPQTSD", "length": 799, "header": "tr|F1N565-1|ZC3HE_BOVIN Computationally mapped isoform of Zinc finger CCCH domain-containing protein 14 OS=Bos taurus OX=9913 GN=ZC3H14 PE=2 SV=4 CANONICAL=Q3ZC82-1" }, "locus": { "chromosome": "10", "start_pos": 100299552, "end_pos": 100258280, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000042987.5", "url": "https://www.ensembl.org/id/ENSBTAT00000042987.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040588.5", "url": "https://www.ensembl.org/id/ENSBTAP00000040588.5" } ] } }, { "isoform_ac": "F1N567-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82/entry#F1N567-1", "sequence": { "sequence": "GGFLTEVARKQSNEELPDYIMVMVANKKSQDQMTEDLSLFLGNNTIRFTVWLHGVLDKLRSVTTDPASLKSSDTNLFDGNVPSNKSSFSRGDERRHEAAVPPLAVSSTRPEKRESRVSTSSQEQKATNVRQTYDDGAATRLMSTVKPLRELAPSEDVIDIKPEPDDLIDEDLNFVQENPLSQKKTTVTLTYGSSRPSIEIYRPPATRNTDSGAHLNRLQFQQQQNSIHAAKQLDIQSSRVYETGRLCEPEVLNSLEETYSPFFRSNAEKMSIEEENFRKRKLPVVSSVVKVKKFSHDGEEEEEDDDCGSRTGSISSSVSVPAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVSQKQTLPVAPRTRTSQEDLLAEVAQGHGRVPRISSPVKEEEAQGGSVDERQGTQQRQLLSRLQIDPVMAETLQISQDYYDMESMVHADTRSFILKKPKLCEELVVAASQASGMETADALQARSGHLVQTRDLVQPDKPASPKFIVTLDGVPSPPGYMSDQEEDMCSEGMRPAQHPAASHGGLAGLLHPQRSRVLSRQLEDPDGSFANAEMSELSVAQKPEKLLERCKYWPACKNGDECAYHHPVSPCKAFPNCKFAEKCLFVHPNCKYDAKCTKPDCPFTHMSRRTPGLPPKPVTAPAPPSSSQLCRYFPACKKMECPFYHPKHCRFNTQCTRPDCAFYHPTITVPPRHALKWIRPQTR", "length": 720, "header": "tr|F1N567-1|ZC3HE_BOVIN Computationally mapped isoform of Zinc finger CCCH domain-containing protein 14 OS=Bos taurus OX=9913 GN=ZC3H14 PE=2 SV=4 CANONICAL=Q3ZC82-1" }, "locus": { "chromosome": "10", "start_pos": 100299061, "end_pos": 100263051, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000042986.5", "url": "https://www.ensembl.org/id/ENSBTAT00000042986.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040586.5", "url": "https://www.ensembl.org/id/ENSBTAP00000040586.5" } ] } }, { "isoform_ac": "Q3ZC82-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82/entry#Q3ZC82-1", "sequence": { "sequence": "MEIGTEISRKIRSAIKGKLQELGAYVDEELPDYIMVMVANKKSQDQMTEDLSLFLGNNTIRFTVWLHGVLDKLRSVTTDPASLKSSDTNLFDGNVPSNKSSFSRGDERRHEAAVPPLAVSSTRPEKRESRVSTSSQEQKATNVRQTYDDGAATRLMSTVKPLRELAPSEDVIDIKPEPDDLIDEDLNFVQENPLSQKKTTVTLTYGSSRPSIEIYRPPATRNTDSGAHLNRLQFQQQQNSIHAAKQLDIQSSRVYETGRLCEPEVLNSLEETYSPFFRSNAEKMSIEEENFRKRKLPVVSSVVKVKKFSHDGEEEEEDDDCGSRTGSISSSVSVPAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVSQKQTLPVAPRTRTSQEDLLAEVAQGHGRVPRISSPVKEEEAQGGSVDERQGTQQRQLLSRLQIDPVMAETLQISQDYYDMESMVHADTRSFILKKPKLCEELVVAASQASGMETADALQARSGHLVQTRDLVQPDKPASPKFIVTLDGVPSPPGYMSDQEEDMCSEGMRPAQHPAASHGGLAGLLHPQRSRVLSRQLEDPDGSFANAEMSELSVAQKPEKLLERCKYWPACKNGDECAYHHPVSPCKAFPNCKFAEKCLFVHPNCKYDAKCTKPDCPFTHMSRRTPGLPPKPVTAPAPPSSSQLCRYFPACKKMECPFYHPKHCRFNTQCTRPDCAFYHPTITVPPRHALKWIRPQTSD", "length": 735, "header": "sp|Q3ZC82-1|ZC3HE_BOVIN Isoform 1 of Zinc finger CCCH domain-containing protein 14 OS=Bos taurus OX=9913 GN=ZC3H14 PE=2 SV=2 CANONICAL=Q3ZC82-1" }, "locus": { "chromosome": "10", "start_pos": 100299552, "end_pos": 100258280, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086942.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086942.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064177.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064177.1" } ] } }, { "isoform_ac": "Q3ZC82-2", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82/entry#Q3ZC82-2", "sequence": { "sequence": "MEIGTEISRKIRSAIKGKLQELGAYVDEELPDYIMVMVANKKSQDQMTEDLSLFLGNNTIRFTVWLHGVLDKLRSVTTDPASLKSSDTNLFDGNVPSNKSSFSRGDERRHEAAVPPLAVSSTRPEKRESRVSTSSQEQKATNVRQTYDDGAATRLMSTVKPLRELAPSEDVIDIKPEPDDLIDEDLNFVQENPLSQKKTTVTLTYGSSRPSIEIYRPPATRNTDSGAHLNRLQFQQQQNSIHAAKQLDIQSSRVYETGRLCEPEVLNSLEETYSPFFRSNAEKMSIEEENFRKRKLPVVSSVVKVKKFSHDGEEEEEDDDCGSRTGSISSSVSVPAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVSQKQTLPVAPRTRTSQEDLLAEVAQGHGRVPRISSPVKEEEAQGGSVDERQGTQQRQLLSRLQIDPVMAETLQISQAEMSELSVAQKPEKLLERCKYWPACKNGDECAYHHPVSPCKAFPNCKFAEKCLFVHPNCKYDAKCTKPDCPFTHMSRRTPGLPPKPVTAPAPPSSSQLCRYFPACKKMECPFYHPKHCRFNTQCTRPDCAFYHPTITVPPRHALKWIRPQTSD", "length": 604, "header": "sp|Q3ZC82-2|ZC3HE_BOVIN Isoform 2 of Zinc finger CCCH domain-containing protein 14 OS=Bos taurus OX=9913 GN=ZC3H14 PE=2 SV=2 CANONICAL=Q3ZC82-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 240, "end_pos": 240, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC82", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82" } ], "site_lbl": "Ser240" }, { "start_pos": 309, "end_pos": 309, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC82", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82" } ], "site_lbl": "Ser309" }, { "start_pos": 327, "end_pos": 327, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC82", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82" } ], "site_lbl": "Ser327" }, { "start_pos": 343, "end_pos": 343, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC82", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82" } ], "site_lbl": "Ser343" }, { "start_pos": 390, "end_pos": 390, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC82", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82" } ], "site_lbl": "Ser390" }, { "start_pos": 409, "end_pos": 409, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC82", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82" } ], "site_lbl": "Ser409" }, { "start_pos": 421, "end_pos": 421, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC82", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82" } ], "site_lbl": "Ser421" }, { "start_pos": 498, "end_pos": 498, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC82", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82" } ], "site_lbl": "Ser498" }, { "start_pos": 515, "end_pos": 515, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC82", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82" } ], "site_lbl": "Ser515" }, { "start_pos": 527, "end_pos": 527, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC82", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82" } ], "site_lbl": "Ser527" }, { "start_pos": 620, "end_pos": 620, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC82", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82" } ], "site_lbl": "Ser620" }, { "start_pos": 85, "end_pos": 85, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC82", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82" } ], "site_lbl": "Ser85" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511473", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511473", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z443-1", "protein_name": "Zinc finger CCCH domain-containing protein 14", "gene_name": "ZC3H14", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNDLLKPSGTFVFAPWERKGAIKGKLQELGAYVDEELPDYIMVMVANKKSQEQMTEDLSLFLGNNTVRFTVWLHGVLDKLRSVTTEPSGTKSSEPNIFESNHSSSKSSSCVSDERRREDTLPPLAVSSTRSERTDSRVSTSSQEQRNTASRQSCEDGSASRLMSTVKPLRELSPSEAVIDIKPEPDDLIDEDLNFVQENPLSRKKPIVTVTYGSSRPTAEIYRPPASRSADGSLQVHRLPQQGNLQGNRQLDTQSCRSLETVQLCNPEAFGSLAESYRPTSKLSADKVGSEEEGSRKRRLPIVSSVVKVKKFCNDGEEEEEEEDYGLRTGSISSSVSVPAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSAVPQKQTVPVAPRTRISPEESHLEVIHLQSRLPALCSQLQVEEPKEQAVEGIQGAEQKELSSRLQVDPVIEDTLQVTQDYYDGESMVHTDTRSFILKKPKLSEEIAAQNQQLGKRATEAMRVLSGRLIQTRDQIAQPEKPASPKFIVTLDGVPSPPGYLSDQEEEDMYITEGLKPIPQNICAGKGLKGLRAQQMQIVTRQLDSSDVEMEQLNVLQKQEKVLERCKYWPACKNGDECVYHHPTQPCKVFPNCKFADKCLFIHPNCKYDAKCTKPDCPYTHASRRNPLPSPKPVPLPTQSVSSSSPLCKFFPACKKMECPFYHPKHCRFNTQCTRPDCTFYHPTIAVPPRHALKWTRTQTSE", "length": 737 }, "evidence": [ { "id": "Q3ZC82", "url": "https://omabrowser.org/oma/group/Q3ZC82/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q5TYQ8-1", "protein_name": "Zinc finger CCCH domain-containing protein 14", "gene_name": "zc3h14", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEIGTEISKKIRTAIKGKLQEFGAYVDEELPDYIMVMVANKKNPQQMADDLSLFLGNNTIKFTVWLHGVLEKLRSVAVEPPSLGPSVVHSETSIPAENSRRGAEPRALAVSSSRSDKAEGRVSSSAHENRASKRGSSERPSRLTSAVKPLMEASAEAVIDIKPDLDDDLISYDPVEHSLTSGHSQALYSRSTAERQRPAVESSRRTADTYRSSDISRGQDRSERGYRSSAESSRDLSRKRKAPVASSVVRVHRGHERGLEIEDLEEEEEDEDYGLASKVSLPSKPERKPTLPPAKQANKNLILKAISEAQESINKTTSQYTVPQRQTVPVAPRTRSASDEMSNAAIRLVQEHLHALTPQDTLHNTQSRGLASRLQLEVPEEDSREPHEYELQVLEAARLKALDTRSFIMRQPEVEQPPPIRSRLSAVNQNENAPTTSRMVQARERAEAVGGSSPKFIVTLDGVPSPLANRTDQEMETEDELNTTADLPENNNNNNTTTTTSKPAVHLRLGADLRNACDDEVEEMDIEAVQAKRQKLPERCKFWPTCKSGDECLYHHPNTQCKVFPNCKFADKCLFIHPNCKFDAKCTKADCPFTHVSRRLNSNPTRAAPALTSTVCRFFPECKKVDCPFYHPKPCRFATQCKRADCTFYHPAVAVPPRSALKWTKTQSS", "length": 669 }, "evidence": [ { "id": "Q3ZC82", "url": "https://omabrowser.org/oma/group/Q3ZC82/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6PJT7-1", "protein_name": "Zinc finger CCCH domain-containing protein 14", "gene_name": "ZC3H14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEIGTEISRKIRSAIKGKLQELGAYVDEELPDYIMVMVANKKSQDQMTEDLSLFLGNNTIRFTVWLHGVLDKLRSVTTEPSSLKSSDTNIFDSNVPSNKSNFSRGDERRHEAAVPPLAIPSARPEKRDSRVSTSSQESKTTNVRQTYDDGAATRLMSTVKPLREPAPSEDVIDIKPEPDDLIDEDLNFVQENPLSQKKPTVTLTYGSSRPSIEIYRPPASRNADSGVHLNRLQFQQQQNSIHAAKQLDMQSSWVYETGRLCEPEVLNSLEETYSPFFRNNSEKMSMEDENFRKRKLPVVSSVVKVKKFNHDGEEEEEDDDYGSRTGSISSSVSVPAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVPQKQTLPVAPRTRTSQEELLAEVVQGQSRTPRISPPIKEEETKGDSVEKNQGTQQRQLLSRLQIDPVMAETLQMSQDYYDMESMVHADTRSFILKKPKLSEEVVVAPNQESGMKTADSLRVLSGHLMQTRDLVQPDKPASPKFIVTLDGVPSPPGYMSDQEEDMCFEGMKPVNQTAASNKGLRGLLHPQQLHLLSRQLEDPNGSFSNAEMSELSVAQKPEKLLERCKYWPACKNGDECAYHHPISPCKAFPNCKFAEKCLFVHPNCKYDAKCTKPDCPFTHVSRRIPVLSPKPAVAPPAPPSSSQLCRYFPACKKMECPFYHPKHCRFNTQCTRPDCTFYHPTINVPPRHALKWIRPQTSE", "length": 736 }, "evidence": [ { "id": "Q3ZC82", "url": "https://omabrowser.org/oma/group/Q3ZC82/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7TMD5-1", "protein_name": "Zinc finger CCCH domain-containing protein 14", "gene_name": "Zc3h14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEIGTEISRKIRSAIKGKLQELGAYVDEELPDYIMVMVANKKSQDQMTEDLSLFLGNNTIRFTVWLHGVLDKLRSVTTEPSSLKSPDTSIFDSNVPSNKSSFSRGDERRHEAAIPPLAVSSSRPEKRDSRVSTSSQEHKSTNVRHSYDDGASTRLMSTVKPLREPAPSEDVIDIKPEPDDLIDEDLNFVQENSLSQKKPTVTLTYGSSRPSIEIYRPPASRNADTGTHLNRPQLQQQQSSTHTAKQLDGQSSQVYEAGRLCEPEVLGSVEDTYSPFFRNNLDKMNIEEENFRKRKLPVVSSVVKVKRFSHDGEEEEEDEDYGTRVGSLSSSVSVPAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYPAVPQKQTLPVAPRTRTSQEEVLAEMVQGQNRAPRISPPVKEEEAKGDNAEKIEGTQQRQLLSRLQIDPVTVDTMELSQDYYDMESMVHADTRSFILKKPKLSEEIVVTPNQDSGMKTADALRVLSGHLMQTRDLVQPDKPASPKFIVTLDGVPSPPGYMSDQEEEMCFEGMKPVNQTSASNKGLRGLLHPQQLHLLSRQLEDPDGSFSNAEMTDLSVAQKPEKLLERCKYWPACKNGDECVYHHPISPCKAFPNCKFAEKCLFVHPNCKYDAKCTKADCPFTHMSRRGPVLTPKPAVSSPAPSSNGQFCRYFPACKKMECPFYHPKHCRFNTQCTRPDCTFYHPTITVPPRHALKWIRPQTSE", "length": 736 }, "evidence": [ { "id": "Q3ZC82", "url": "https://omabrowser.org/oma/group/Q3ZC82/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BJ05-1", "protein_name": "Zinc finger CCCH domain-containing protein 14", "gene_name": "Zc3h14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEIGTEISRKIRSAIKGKLQELGAYVDEELPDYIMVMVANKKSQDQMTEDLSLFLGNNTIRFTVWLHGVLDKLRSVTTEPSSLKSPDASIFDSHVPSNKSSFSRGDERRHEAAVPPLAVSSSRPEKRDSRVSTSSQEQKSTNVRHSYDDGASTRLMSTVKPLREPAPSEDVIDIKPEPDDLIDEDLNFVQENPLSQKKPTVTLTYGSSRPSIEIYRPPASRNADTGTHLNRLQLHPQQSSAHAAKQLDVQSSQVSEAGRLCEPPVLSSVEDTYSPFFRNNLDKMSIEDENFRKRKLPVVSSVVKVKRFSHDGEEEEEDEDYGTRIGSLSSSVSVPAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSAVPQKQTLPVAPRTRTSQEELLAEMVQGQNRAPRISPPVKEEEAKGDNTGKSQGTQQRQLLSRLQIDPVMVETMEMSQDYYDMESMVHADTRSFILKKPKLSEEIVVTPNQDSGMKTADALRVLSGHLMQTRDLVQPDKPASPKFIVTLDGVPSPPGYMSDQEEEMCFEGMKPVNQTSASNKGLRGLLHPQQLHLLSRQLEDPDGSFSNAEMTDLSVAQKPEKLLERCKYWPACKNGDECVYHHPISPCKAFPNCKFAEKCLFVHPNCKYDTKCTKADCPFTHMSRRASILTPKPVSSPAPSSNGQLCRYFPACKKMECPFYHPKHCRFNTQCTRPDCTFYHPTITVPPRHALKWIRPQSSE", "length": 735 }, "evidence": [ { "id": "Q3ZC82", "url": "https://omabrowser.org/oma/group/Q3ZC82/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "pre-mRNA binding", "id": "GO:0036002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036002", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC82", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC82", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82" } ], "pmid": "" }, { "name": "poly(A) binding", "id": "GO:0008143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008143", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC82", "url": "https://www.uniprot.org/uniprotkb/Q3ZC82" } ], "pmid": "" }, { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC82", "url": 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{ "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBV3-1", "uniprot_ac": "Q3ZBV3", "uniprot_id": "MGN_BOVIN", "mass": { "chemical_mass": 17164.0, "monoisotopic_mass": 17164.0 }, "refseq": { "ac": "NP_001029417", "name": "protein mago nashi homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029417" }, "gene_names": [ { "name": "MAGOH", "type": "recommended", "evidence": [ { "id": "Q3ZBV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3" } ] }, { "name": "MAGOH", "type": "synonym", "evidence": [ { "id": "NP_001029417", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029417" } ] } ], "protein_names": [ { "name": "Protein mago nashi homolog", "type": "recommended", "evidence": [ { "id": "Q3ZBV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3/entry#names_and_taxonomy" } ] }, { "name": "mago homolog, exon junction complex core component", "type": "synonym", "evidence": [ { "id": "NP_001029417", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029417" } ] }, { "name": "mago-nashi homolog, proliferation-associated", "type": "synonym", "evidence": [ { "id": "NP_001029417", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029417" } ] }, { "name": "protein mago nashi homolog", "type": "synonym", "evidence": [ { "id": "NP_001029417", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029417" } ] } ], "function": [ { "annotation": "Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S pre-initiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3#function" }, { "database": "UniProtKB", "id": "P61326", "url": "https://www.uniprot.org/uniprotkb/P61326#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAGOH", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3", "locus": { "chromosome": "3", "start_pos": 93012322, "end_pos": 93003066, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003485", "url": "https://www.ensembl.org/id/ENSBTAG00000003485" } ] } } ], "crossref": [ { "id": "Q3ZBV3", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBV3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003485", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003485", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11295", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11295", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505417", "url": "https://www.ncbi.nlm.nih.gov/gene/505417", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004023", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004023", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036605", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036605", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505417", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505417", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NQTDEFY", "url": "https://omabrowser.org/oma/group/NQTDEFY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DHY5", "url": "https://www.orthodb.org/?gene=A0A452DHY5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBV3", "url": "https://www.orthodb.org/?gene=Q3ZBV3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12638", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12638", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12638:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12638:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12638:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12638:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02792", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02792", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-159236", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159236", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029417", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DHY5", "url": "https://www.uniprot.org/uniprotkb/A0A452DHY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DHY5-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DHY5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9B8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9B8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBV3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBV3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI", "length": 146, "header": "sp|Q3ZBV3-1|MGN_BOVIN Isoform 1 of Protein mago nashi homolog OS=Bos taurus OX=9913 GN=MAGOH PE=2 SV=1 CANONICAL=Q3ZBV3-1" }, "isoforms": [ { "isoform_ac": "A0A452DHY5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3/entry#A0A452DHY5-1", "sequence": { "sequence": "RAMESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI", "length": 148, "header": "tr|A0A452DHY5-1|MGN_BOVIN Computationally mapped isoform of Protein mago nashi homolog OS=Bos taurus OX=9913 GN=MAGOH PE=2 SV=1 CANONICAL=Q3ZBV3-1" }, "locus": { "chromosome": "3", "start_pos": 93012180, "end_pos": 93003161, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004528.3", "url": "https://www.ensembl.org/id/ENSBTAT00000004528.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004528.3", "url": "https://www.ensembl.org/id/ENSBTAP00000004528.3" } ] } }, { "isoform_ac": "A0AAA9T9B8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3/entry#A0AAA9T9B8-1", "sequence": { "sequence": "MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI", "length": 109, "header": "tr|A0AAA9T9B8-1|MGN_BOVIN Computationally mapped isoform of Protein mago nashi homolog OS=Bos taurus OX=9913 GN=MAGOH PE=2 SV=1 CANONICAL=Q3ZBV3-1" }, "locus": { "chromosome": "3", "start_pos": 93012180, "end_pos": 93003161, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091284.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091284.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094592.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094592.1" } ] } }, { "isoform_ac": "Q3ZBV3-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3/entry#Q3ZBV3-1", "sequence": { "sequence": "MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI", "length": 146, "header": "sp|Q3ZBV3-1|MGN_BOVIN Isoform 1 of Protein mago nashi homolog OS=Bos taurus OX=9913 GN=MAGOH PE=2 SV=1 CANONICAL=Q3ZBV3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505417", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505417", "resource": "KEGG Pathway" }, { "id": "R-BTA-159236", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159236", "resource": "Reactome", "description": "Transport of Mature mRNA derived from an Intron-Containing Transcript" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1WAU1-1", "protein_name": "Mago homolog, exon junction complex subunit", "gene_name": "MAGOH", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI", "length": 146 }, "evidence": [ { "id": "Q3ZBV3", "url": "https://omabrowser.org/oma/group/Q3ZBV3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MEL4-1", "protein_name": "Protein mago nashi homolog 2 isoform X1", "gene_name": "Magohb", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSMASDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI", "length": 148 }, "evidence": [ { "id": "Q3ZBV3", "url": "https://omabrowser.org/oma/group/Q3ZBV3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P61326-1", "protein_name": "Protein mago nashi homolog", "gene_name": "MAGOH", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI", "length": 146 }, "evidence": [ { "id": "Q3ZBV3", "url": "https://omabrowser.org/oma/group/Q3ZBV3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q27W02-1", "protein_name": "Protein mago nashi homolog", "gene_name": "Magoh", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI", "length": 146 }, "evidence": [ { "id": "Q3ZBV3", "url": "https://omabrowser.org/oma/group/Q3ZBV3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q566Y8-1", "protein_name": "Protein mago nashi homolog", "gene_name": "magoh", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSTSDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI", "length": 147 }, "evidence": [ { "id": "Q3ZBV3", "url": "https://omabrowser.org/oma/group/Q3ZBV3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q96A72-1", "protein_name": "Protein mago nashi homolog 2", "gene_name": "MAGOHB", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAVASDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI", "length": 148 }, "evidence": [ { "id": "Q3ZBV3", "url": "https://omabrowser.org/oma/group/Q3ZBV3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3" } ], "pmid": "" }, { "name": "catalytic step 2 spliceosome", "id": "GO:0071013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071013", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3" } ], "pmid": "" }, { "name": "exon-exon junction complex", "id": "GO:0035145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035145", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3" } ], "pmid": "" }, { "name": "exon-exon junction subcomplex mago-y14", "id": "GO:1990501", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990501", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3" } ], "pmid": "" }, { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "mRNA export from nucleus", "id": "GO:0006406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006406", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3" } ], "pmid": "" }, { "name": "regulation of translation", "id": "GO:0006417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006417", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3" } ], "pmid": "" }, { "name": "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "id": "GO:0000184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000184", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3" } ], "pmid": "" }, { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3" } ], "pmid": "" }, { "name": "regulation of alternative mRNA splicing, via spliceosome", "id": "GO:0000381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000381", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3" } ], "pmid": "" }, { "name": "regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "id": "GO:2000622", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000622", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3" } ], "pmid": "" }, { "name": "mRNA transport", "id": "GO:0051028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051028", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 36, "end_pos": 38, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBV3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 146, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBV3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBV3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 111, "end_pos": 113 }, { "start_pos": 36, "end_pos": 38 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q5EA68-1", "uniprot_ac": "Q5EA68", "uniprot_id": "S61A1_BOVIN", "mass": { "chemical_mass": 52225.0, "monoisotopic_mass": 52225.0 }, "refseq": { "ac": "NP_001035594", "name": "protein transport protein Sec61 subunit alpha isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035594" }, "gene_names": [ { "name": "SEC61A1", "type": "recommended", "evidence": [ { "id": "Q5EA68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA68" } ] }, { "name": "SEC61A1", "type": "synonym", "evidence": [ { "id": "NP_001035594", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035594" } ] } ], "protein_names": [ { "name": "Protein transport protein Sec61 subunit alpha isoform 1", "type": "recommended", "evidence": [ { "id": "Q5EA68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA68/entry#names_and_taxonomy" } ] }, { "name": "SEC61 translocon alpha 1 subunit", "type": "synonym", "evidence": [ { "id": "NP_001035594", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035594" } ] }, { "name": "Sec61 alpha 1 subunit", "type": "synonym", "evidence": [ { "id": "NP_001035594", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035594" } ] }, { "name": "Sec61 alpha form 1", "type": "synonym", "evidence": [ { "id": "NP_001035594", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035594" } ] }, { "name": "Sec61 alpha-1", "type": "synonym", "evidence": [ { "id": "Q5EA68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA68/entry#names_and_taxonomy" } ] }, { "name": "protein transport protein Sec61 subunit alpha isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001035594", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035594" } ] }, { "name": "protein transport protein Sec61 subunit alpha", "type": "synonym", "evidence": [ { "id": "NP_001035594", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035594" } ] }, { "name": "sec61 alpha-1", "type": "synonym", "evidence": [ { "id": "NP_001035594", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035594" } ] } ], "function": [ { "annotation": "Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (By similarity). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5EA68", "url": "https://www.uniprot.org/uniprotkb/Q5EA68#function" }, { "database": "UniProtKB", "id": "P61619", "url": "https://www.uniprot.org/uniprotkb/P61619#function" }, { "database": "UniProtKB", "id": "P61620", "url": "https://www.uniprot.org/uniprotkb/P61620#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA68", "url": "https://www.uniprot.org/uniprotkb/Q5EA68" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SEC61A1", "url": "https://www.uniprot.org/uniprotkb/Q5EA68", "locus": { "chromosome": "22", "start_pos": 59545677, "end_pos": 59559392, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004937", "url": "https://www.ensembl.org/id/ENSBTAG00000004937" } ] } } ], "crossref": [ { "id": "Q5EA68", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA68", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004937", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004937", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505064", "url": "https://www.ncbi.nlm.nih.gov/gene/505064", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002208", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002208", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019561", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019561", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030659", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030659", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505064", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505064", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PMMRQMF", "url": "https://omabrowser.org/oma/group/PMMRQMF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DI19", "url": "https://www.orthodb.org/?gene=A0A452DI19", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5EA68", "url": "https://www.orthodb.org/?gene=Q5EA68", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10906", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10906", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10559", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10559", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035594", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DI19", "url": "https://www.uniprot.org/uniprotkb/A0A452DI19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DI19-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DI19-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMH5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMH5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA68", "url": "https://www.uniprot.org/uniprotkb/Q5EA68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA68-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA68-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMTITIGQSIVYVMTGMYGDPSEMGAGVCLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF", "length": 476, "header": "sp|Q5EA68-1|S61A1_BOVIN Isoform 1 of Protein transport protein Sec61 subunit alpha isoform 1 OS=Bos taurus OX=9913 GN=SEC61A1 PE=2 SV=3 CANONICAL=Q5EA68-1" }, "isoforms": [ { "isoform_ac": "A0A452DI19-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA68/entry#A0A452DI19-1", "sequence": { "sequence": "MGLLSEFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMTITIGQSIVYVMTGMYGDPSEMGAGVCLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF", "length": 478, "header": "tr|A0A452DI19-1|S61A1_BOVIN Computationally mapped isoform of Protein transport protein Sec61 subunit alpha isoform 1 OS=Bos taurus OX=9913 GN=SEC61A1 PE=2 SV=1 CANONICAL=Q5EA68-1" }, "locus": { "chromosome": "22", "start_pos": 59559392, "end_pos": 59547305, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083552.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083552.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057558.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057558.2" } ] } }, { "isoform_ac": "A0AAA9TMH5-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA68/entry#A0AAA9TMH5-1", "sequence": { "sequence": "MGIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMTITIGQSIVYVMTGMYGDPSEMGAGVCLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF", "length": 346, "header": "tr|A0AAA9TMH5-1|S61A1_BOVIN Computationally mapped isoform of Protein transport protein Sec61 subunit alpha isoform 1 OS=Bos taurus OX=9913 GN=SEC61A1 PE=2 SV=1 CANONICAL=Q5EA68-1" }, "locus": { "chromosome": "22", "start_pos": 59558229, "end_pos": 59547305, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122939.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122939.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097528.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097528.1" } ] } }, { "isoform_ac": "Q5EA68-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA68/entry#Q5EA68-1", "sequence": { "sequence": "MGIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMTITIGQSIVYVMTGMYGDPSEMGAGVCLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF", "length": 476, "header": "sp|Q5EA68-1|S61A1_BOVIN Isoform 1 of Protein transport protein Sec61 subunit alpha isoform 1 OS=Bos taurus OX=9913 GN=SEC61A1 PE=2 SV=3 CANONICAL=Q5EA68-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA68", "url": "https://www.uniprot.org/uniprotkb/Q5EA68" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:505064", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505064", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P32915-1", "protein_name": "Protein transport protein SEC61", "gene_name": "SEC61", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSSNRVLDLFKPFESFLPEVIAPERKVPYNQKLIWTGVSLLIFLILGQIPLYGIVSSETSDPLYWLRAMLASNRGTLLELGVSPIITSSMIFQFLQGTQLLQIRPESKQDRELFQIAQKVCAIILILGQALVVVMTGNYGAPSDLGLPICLLLIFQLMFASLIVMLLDELLSKGYGLGSGISLFTATNIAEQIFWRAFAPTTVNSGRGKEFEGAVIAFFHLLAVRKDKKRALVEAFYRTNLPNMFQVLMTVAIFLFVLYLQGFRYELPIRSTKVRGQIGIYPIKLFYTSNTPIMLQSALTSNIFLISQILFQKYPTNPLIRLIGVWGIRPGTQGPQMALSGLAYYIQPLMSLSEALLDPIKTIVYITFVLGSCAVFSKTWIEISGTSPRDIAKQFKDQGMVINGKRETSIYRELKKIIPTAAAFGGATIGALSVGSDLLGTLGSGASILMATTTIYGYYEAAAKEGGFTKNLVPGFSDLM", "length": 480 }, "evidence": [ { "id": "Q5EA68", "url": "https://omabrowser.org/oma/group/Q5EA68/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P61619-1", "protein_name": "Protein transport protein Sec61 subunit alpha isoform 1", "gene_name": "SEC61A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF", "length": 476 }, "evidence": [ { "id": "Q5EA68", "url": "https://omabrowser.org/oma/group/Q5EA68/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P61620-1", "protein_name": "Protein transport protein Sec61 subunit alpha isoform 1", "gene_name": "Sec61a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF", "length": 476 }, "evidence": [ { "id": "Q5EA68", "url": "https://omabrowser.org/oma/group/Q5EA68/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54XK2-1", "protein_name": "Protein transport protein Sec61 subunit alpha", "gene_name": "sec61a", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGFRFLDIVKPFTSLVPEVGQPDRKIPFREKVLWTAICLFIFLVCSQIPLYGIRSTDSSDPFYWAKVIMASNRGTLMELGISPIVTSGMVMQLLAGAKLIEIDQSVKADRDLFSAAQKLFGMLICVGQGVAYIWSGSYGDPAVLGFGNCFLIVLQLFFAGIIVMLLDELLQKGYGIGSGISLFIATNICETIVWKTFSPTTVSVGKGTEFEGAVIALFHLLLTRNDKVRALKEAFYRQNLPNITNLLATVLIFMVVIYFQGFRVDLPVKSTRVSGQQGTYPIKLFYTSNIPIILQSALVSNLYFISQLLYRRFPDNILVNLFGAWRTSEYSQQMIPVSGLTYYISSPNNMSAVLADPFHALFYITFMLTSCALFSKVWIEVSGSSARDVAKQLKDQQMTMKGHRDTSVIKELNRYIPTAAAFGGLCIGALTVVADFMGAIGSGTGILLAVTIIYQYFETFVKEQQELSGGIGGLF", "length": 475 }, "evidence": [ { "id": "Q5EA68", "url": "https://omabrowser.org/oma/group/Q5EA68/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q90ZM2-1", "protein_name": "Protein transport protein Sec61 subunit alpha-like 1", "gene_name": "sec61al1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAIKFLEVIKPFCAVLPEIQKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQAIVYVMTGMYGDPSEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGTEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATVFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSTRFSGNFLVNLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLDDPVHAVIYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGGLSVMADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF", "length": 476 }, "evidence": [ { "id": "Q5EA68", "url": "https://omabrowser.org/oma/group/Q5EA68/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "protein insertion into ER membrane", "id": "GO:0045048", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045048", "evidence": [ { "database": "UniProtKB", "id": "Q5EA68", "url": "https://www.uniprot.org/uniprotkb/Q5EA68" } ], "pmid": "" }, { "name": "cotranslational protein targeting to membrane", "id": "GO:0006613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006613", "evidence": [ { "database": "UniProtKB", "id": "Q5EA68", "url": "https://www.uniprot.org/uniprotkb/Q5EA68" } ], "pmid": "" }, { "name": "post-translational protein targeting to membrane, translocation", "id": "GO:0031204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031204", "evidence": [ { "database": "UniProtKB", "id": "Q5EA68", "url": "https://www.uniprot.org/uniprotkb/Q5EA68" } ], "pmid": "" }, { "name": "protein targeting to ER", "id": "GO:0045047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045047", "evidence": [ { "database": "UniProtKB", "id": "Q5EA68", "url": "https://www.uniprot.org/uniprotkb/Q5EA68" } ], "pmid": "" }, { "name": "pronephric nephron development", "id": "GO:0039019", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0039019", "evidence": [ { "database": "UniProtKB", "id": "Q5EA68", "url": "https://www.uniprot.org/uniprotkb/Q5EA68" } ], "pmid": "" }, { "name": "SRP-dependent cotranslational protein targeting to membrane, translocation", "id": "GO:0006616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006616", "evidence": [ { "database": "UniProtKB", "id": "Q5EA68", "url": "https://www.uniprot.org/uniprotkb/Q5EA68" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q5EA68", "url": "https://www.uniprot.org/uniprotkb/Q5EA68" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q5EA68", "url": "https://www.uniprot.org/uniprotkb/Q5EA68" } ], "pmid": "" }, { "name": "Sec61 translocon complex", "id": "GO:0005784", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005784", "evidence": [ { "database": "UniProtKB", "id": "Q5EA68", "url": "https://www.uniprot.org/uniprotkb/Q5EA68" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "signal sequence binding", "id": "GO:0005048", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005048", "evidence": [ { "database": "UniProtKB", "id": "Q5EA68", "url": "https://www.uniprot.org/uniprotkb/Q5EA68" } ], "pmid": "" }, { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "Q5EA68", "url": "https://www.uniprot.org/uniprotkb/Q5EA68" } ], "pmid": "" }, { "name": "protein transmembrane transporter activity", "id": "GO:0008320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008320", "evidence": [ { "database": "UniProtKB", "id": "Q5EA68", "url": "https://www.uniprot.org/uniprotkb/Q5EA68" } ], "pmid": "" }, { "name": "calcium channel activity", "id": "GO:0005262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005262", "evidence": [ { "database": "UniProtKB", "id": "Q5EA68", "url": "https://www.uniprot.org/uniprotkb/Q5EA68" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA68-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 476, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA68-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA68" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q8HYI9-1", "uniprot_ac": "Q8HYI9", "uniprot_id": "PFD5_BOVIN", "mass": { "chemical_mass": 17385.0, "monoisotopic_mass": 17385.0 }, "refseq": { "ac": "NP_777157", "name": "prefoldin subunit 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777157" }, "gene_names": [ { "name": "PFDN5", "type": "recommended", "evidence": [ { "id": "Q8HYI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HYI9" } ] }, { "name": "PFDN5", "type": "synonym", "evidence": [ { "id": "NP_777157", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777157" } ] } ], "protein_names": [ { "name": "Prefoldin subunit 5", "type": "recommended", "evidence": [ { "id": "Q8HYI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HYI9/entry#names_and_taxonomy" } ] }, { "name": "prefoldin 5", "type": "synonym", "evidence": [ { "id": "NP_777157", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777157" } ] }, { "name": "prefoldin subunit 5", "type": "synonym", "evidence": [ { "id": "NP_777157", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777157" } ] } ], "function": [ { "annotation": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q8HYI9", "url": "https://www.uniprot.org/uniprotkb/Q8HYI9#function" }, { "database": "UniProtKB", "id": "A0A452DI96", "url": "https://www.uniprot.org/uniprotkb/A0A452DI96#function" }, { "database": "UniProtKB", "id": "ARBA00057914", "url": "https://www.uniprot.org/uniprotkb/ARBA00057914#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q8HYI9", "url": "https://www.uniprot.org/uniprotkb/Q8HYI9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PFDN5", "url": "https://www.uniprot.org/uniprotkb/Q8HYI9", "locus": { "chromosome": "5", "start_pos": 26724556, "end_pos": 26728661, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008935", "url": "https://www.ensembl.org/id/ENSBTAG00000008935" } ] } } ], "crossref": [ { "id": "Q8HYI9", "url": "https://alphafold.ebi.ac.uk/entry/Q8HYI9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008935", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008935", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23157", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23157", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282848", "url": "https://www.ncbi.nlm.nih.gov/gene/282848", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004127", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004127", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009053", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009053", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282848", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282848", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QAKFKAC", "url": "https://omabrowser.org/oma/group/QAKFKAC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DI96", "url": "https://www.orthodb.org/?gene=A0A452DI96", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q8HYI9", "url": "https://www.orthodb.org/?gene=Q8HYI9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12674", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12674", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12674:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12674:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02996", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02996", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_777157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777157", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DI96", "url": "https://www.uniprot.org/uniprotkb/A0A452DI96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DI96-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DI96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXW7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TB61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TB61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB61-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8HYI9", "url": "https://www.uniprot.org/uniprotkb/Q8HYI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8HYI9-1", "url": "https://www.uniprot.org/uniprotkb/Q8HYI9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQSVNITELNLPQLEMLKNQLDQEVEFLSTSIAQLKVVQTKYVEAKDCLNVLKKNNEGKELLVPLTSSMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKDFFKRKIDFLTKQMEKIQPALQEKHAMKQAVMEMMSQKIQQLTTLGAAQATAKA", "length": 154, "header": "sp|Q8HYI9-1|PFD5_BOVIN Isoform 1 of Prefoldin subunit 5 OS=Bos taurus OX=9913 GN=PFDN5 PE=2 SV=1 CANONICAL=Q8HYI9-1" }, "isoforms": [ { "isoform_ac": "A0A452DI96-1", "url": "https://www.uniprot.org/uniprotkb/Q8HYI9/entry#A0A452DI96-1", "sequence": { "sequence": "MAQSVNITELNLPQLEMLKNQLDQEVEFLSTSIAQLKVVQTKYVEAKDCLNVLKKNNEGTGFPLILASQMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKDFFKRKIDFLTKQMEKIQPALQEKHAMKQAVMEMMSQKIQQLTTLGAAQATAKA", "length": 154, "header": "tr|A0A452DI96-1|PFD5_BOVIN Computationally mapped isoform of Prefoldin subunit 5 OS=Bos taurus OX=9913 GN=PFDN5 PE=2 SV=1 CANONICAL=Q8HYI9-1" }, "locus": { "chromosome": "5", "start_pos": 26728656, "end_pos": 26725032, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011762.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011762.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011762.6", "url": "https://www.ensembl.org/id/ENSBTAP00000011762.6" } ] } }, { "isoform_ac": "A0AAA9SXW7-1", "url": "https://www.uniprot.org/uniprotkb/Q8HYI9/entry#A0AAA9SXW7-1", "sequence": { "sequence": "MAQSVNITELNLPQLEMLKNQLDQMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKDFFKRKIDFLTKQMEKIQPALQEKHAMKQAVMEMMSQKIQQLTTLGAAQATAKA", "length": 109, "header": "tr|A0AAA9SXW7-1|PFD5_BOVIN Computationally mapped isoform of Prefoldin subunit 5 OS=Bos taurus OX=9913 GN=PFDN5 PE=2 SV=1 CANONICAL=Q8HYI9-1" }, "locus": { "chromosome": "5", "start_pos": 26728656, "end_pos": 26725032, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110190.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110190.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089080.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089080.1" } ] } }, { "isoform_ac": "A0AAA9TB61-1", "url": "https://www.uniprot.org/uniprotkb/Q8HYI9/entry#A0AAA9TB61-1", "sequence": { "sequence": "MAQSVNITELNLPQLEMLKNQLDQTAEDAKDFFKRKIDFLTKQMEKIQPALQEKHAMKQAVMEMMSQKIQQLTTLGAAQATAKA", "length": 84, "header": "tr|A0AAA9TB61-1|PFD5_BOVIN Computationally mapped isoform of Prefoldin subunit 5 OS=Bos taurus OX=9913 GN=PFDN5 PE=2 SV=1 CANONICAL=Q8HYI9-1" }, "locus": { "chromosome": "5", "start_pos": 26728656, "end_pos": 26725032, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122320.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122320.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095943.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095943.1" } ] } }, { "isoform_ac": "Q8HYI9-1", "url": "https://www.uniprot.org/uniprotkb/Q8HYI9/entry#Q8HYI9-1", "sequence": { "sequence": "MAQSVNITELNLPQLEMLKNQLDQEVEFLSTSIAQLKVVQTKYVEAKDCLNVLKKNNEGKELLVPLTSSMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKDFFKRKIDFLTKQMEKIQPALQEKHAMKQAVMEMMSQKIQQLTTLGAAQATAKA", "length": 154, "header": "sp|Q8HYI9-1|PFD5_BOVIN Isoform 1 of Prefoldin subunit 5 OS=Bos taurus OX=9913 GN=PFDN5 PE=2 SV=1 CANONICAL=Q8HYI9-1" }, "locus": { "chromosome": "5", "start_pos": 26728656, "end_pos": 26725032, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081994.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081994.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061773.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061773.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:282848", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282848", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5NXK7-1", "protein_name": "Prefoldin subunit 5", "gene_name": "PFDN5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAQAVNVAELPLPQLEVLKNQLDQEVEFLSSSITQLKVVQTKYVEAKDCLNVLNKSNEGKDLLVPLTSSMYVPGKLSDVERVLIDVGTGYYVEKTADDAREFFKRKIDFLTKQMEKIQPALQEKHAMKQAVVEMMSQKIQQLTALGAAQGATTKA", "length": 155 }, "evidence": [ { "id": "Q8HYI9", "url": "https://omabrowser.org/oma/group/Q8HYI9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F7FF81-1", "protein_name": "Prefoldin subunit 5", "gene_name": "Pfdn5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"sequence": { "sequence": "MASSSSRGEMEKMGIDQLKALKEQADLEVNLLQDSLNNIRTATVRLDAAAAALNDLSLRPQGKKMLVPLTASLYVPGTLDEADKVLVDIGTGYFIEKTMDDGKDYCQRKINLLKSNFDQLFEVAAKKKSVADEAGMVLQAKVKQLTAATTS", "length": 151 }, "evidence": [ { "id": "Q8HYI9", "url": "https://omabrowser.org/oma/group/Q8HYI9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q04493-1", "protein_name": "Prefoldin subunit 5", "gene_name": "GIM5", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSSQKIDLTKLNPEQLNAVKQQFDQELQHFTQSLQALTMAKGKFTECIDDIKTVSQAGNEGQKLLVPASASLYIPGKIVDNKKFMVDIGTGYYVEKSAEAAIAFYQKKVDKLNKESVQIQDIIKEKTQYSLSIEAQIRQAAIRQHEAMSKQQQQQQKKESSTA", "length": 163 }, "evidence": [ { "id": "Q8HYI9", "url": "https://omabrowser.org/oma/group/Q8HYI9/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54V55-1", "protein_name": "Probable prefoldin subunit 5", "gene_name": "pfdn5", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSEPQQQQVNLGSLSLEQLQMVREQVEAEIQQLSESIQQLKHASNKYIEAKEAMGGLKGTDGKDMLVPLTSSIYLPGKINSNEKVLVDIGTGYYVEMGIEQGQNFSNRKVQLITEQVNKVQTAINMKRQNLESIVQVAQSKISLYKQQQAQQSQQQVQQK", "length": 160 }, "evidence": [ { "id": "Q8HYI9", "url": "https://omabrowser.org/oma/group/Q8HYI9/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q99471-1", "protein_name": "Prefoldin subunit 5", "gene_name": "PFDN5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQSINITELNLPQLEMLKNQLDQEVEFLSTSIAQLKVVQTKYVEAKDCLNVLNKSNEGKELLVPLTSSMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKDFFKRKIDFLTKQMEKIQPALQEKHAMKQAVMEMMSQKIQQLTALGAAQATAKA", "length": 154 }, "evidence": [ { "id": "Q8HYI9", "url": "https://omabrowser.org/oma/group/Q8HYI9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VCZ8-1", "protein_name": "Probable prefoldin subunit 5", "gene_name": "Pfdn5", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAATPSAPAKSEMIDLTKLSPEQLIQIKQEFEQEITNVQDSLSTLHGCQAKYAGSKEALGTFQPNWENRQILVPLTSSMYVPGRVKDLNRFVIDIGTGYYIEKDLEGSKDYFKRRVEYVQEQIEKIEKIHLQKTRFYNSVMSVLEMKQAAAAKLQSQQQSQPAVTQSS", "length": 168 }, "evidence": [ { "id": "Q8HYI9", "url": "https://omabrowser.org/oma/group/Q8HYI9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9WU28-1", "protein_name": "Prefoldin subunit 5", "gene_name": "Pfdn5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQSINITELNLPQLEMLKNQLDQEVEFLSTSIAQLKVVQTKYVEAKDCLNVLNKSNEGKELLVPLTSSMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKDFFKRKIDFLTKQMEKIQPALQEKHAMKQAVMEMMSQKIQQLTALGAAQATVKA", "length": 154 }, "evidence": [ { "id": "Q8HYI9", "url": "https://omabrowser.org/oma/group/Q8HYI9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q8HYI9", "url": "https://www.uniprot.org/uniprotkb/Q8HYI9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q8HYI9", "url": "https://www.uniprot.org/uniprotkb/Q8HYI9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q8HYI9", "url": "https://www.uniprot.org/uniprotkb/Q8HYI9" } ], "pmid": "" }, { "name": "prefoldin complex", "id": "GO:0016272", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016272", "evidence": [ { "database": "UniProtKB", "id": "Q8HYI9", "url": 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} ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBK6-1", "uniprot_ac": "Q3ZBK6", "uniprot_id": "LSM4_BOVIN", "mass": { "chemical_mass": 15350.0, "monoisotopic_mass": 15350.0 }, "refseq": { "ac": "NP_001030513", "name": "U6 snRNA-associated Sm-like protein LSm4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030513" }, "gene_names": [ { "name": "LSM4", "type": "recommended", "evidence": [ { "id": "Q3ZBK6", "database": "UniProtKB", "url": 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The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A9M7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9M7#function" }, { "database": "UniProtKB", "id": "ARBA00056431", "url": "https://www.uniprot.org/uniprotkb/ARBA00056431#function" }, { "database": "UniProtKB", "id": "A0A452DI98", "url": "https://www.uniprot.org/uniprotkb/A0A452DI98#function" }, { "database": "UniProtKB", "id": "Q3ZBK6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK6#function" }, { "database": "UniProtKB", "id": "Q9Y4Z0", "url": "https://www.uniprot.org/uniprotkb/Q9Y4Z0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LSM4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK6", "locus": { "chromosome": "7", "start_pos": 4893672, "end_pos": 4881009, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008578", "url": "https://www.ensembl.org/id/ENSBTAG00000008578" } ] } } ], "crossref": [ { "id": "Q3ZBK6", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBK6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008578", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008578", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01723", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01723", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613634", "url": "https://www.ncbi.nlm.nih.gov/gene/613634", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001163", "database": 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"https://www.orthodb.org/?gene=A0A452DI98", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBK6", "url": "https://www.orthodb.org/?gene=Q3ZBK6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23338", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23338", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01423", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01423", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-430039", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-430039", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030513", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DI98", "url": "https://www.uniprot.org/uniprotkb/A0A452DI98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DI98-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DI98-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A9M7", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9M7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A9M7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A9M7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBK6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBK6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLPLSLLKTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVKEEVVAKGRGRGGLQQQKQQKGRGMGGAGRGVFGGRGRGGIPGTGRGQPEKKPGRQAGKQ", "length": 139, "header": "sp|Q3ZBK6-1|LSM4_BOVIN Isoform 1 of U6 snRNA-associated Sm-like protein LSm4 OS=Bos taurus OX=9913 GN=LSM4 PE=2 SV=1 CANONICAL=Q3ZBK6-1" }, "isoforms": [ { "isoform_ac": "A0A452DI98-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK6/entry#A0A452DI98-1", "sequence": { "sequence": "MLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVKEEVVAKGRGRGGLQQQKQQKGRGMGGAGRGVFGGRGRGGIPGTGRGQPEKKPGRQAGKQ", "length": 125, "header": "tr|A0A452DI98-1|LSM4_BOVIN Computationally mapped isoform of U6 snRNA-associated Sm-like protein LSm4 OS=Bos taurus OX=9913 GN=LSM4 PE=2 SV=2 CANONICAL=Q3ZBK6-1" }, "locus": { "chromosome": "7", "start_pos": 4893132, "end_pos": 4881084, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011312.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011312.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011312.7", "url": "https://www.ensembl.org/id/ENSBTAP00000011312.7" } ] } }, { "isoform_ac": "A0AAF7A9M7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK6/entry#A0AAF7A9M7-1", "sequence": { "sequence": "MCTYTPSLLDLLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVKEEVVAKGRGRGGLQQQKQQKGRGMGGAGRGRPFSPPSPLVPGTHLGGLYAEPGRT", "length": 131, "header": "tr|A0AAF7A9M7-1|LSM4_BOVIN Computationally mapped isoform of U6 snRNA-associated Sm-like protein LSm4 OS=Bos taurus OX=9913 GN=LSM4 PE=2 SV=1 CANONICAL=Q3ZBK6-1" }, "locus": { "chromosome": "7", "start_pos": 4891959, "end_pos": 4887705, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085767.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085767.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065542.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065542.2" } ] } }, { "isoform_ac": "Q3ZBK6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK6/entry#Q3ZBK6-1", "sequence": { "sequence": "MLPLSLLKTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVKEEVVAKGRGRGGLQQQKQQKGRGMGGAGRGVFGGRGRGGIPGTGRGQPEKKPGRQAGKQ", "length": 139, "header": "sp|Q3ZBK6-1|LSM4_BOVIN Isoform 1 of U6 snRNA-associated Sm-like protein LSm4 OS=Bos taurus OX=9913 GN=LSM4 PE=2 SV=1 CANONICAL=Q3ZBK6-1" }, "locus": { "chromosome": "7", "start_pos": 4893132, "end_pos": 4881084, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110193.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110193.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100020.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100020.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613634", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613634", "resource": "KEGG Pathway" }, { "id": "R-BTA-430039", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-430039", "resource": "Reactome", "description": "mRNA decay by 5' to 3' exoribonuclease" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4FR34-1", "protein_name": "U6 snRNA-associated Sm-like protein LSm4", "gene_name": "LSM4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLPLSLLKTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVKEEVVAKGRGRGGLQQQKQQKGRGMGGAGRGVFGGRGRGGIPGTGRGQPEKKPGRQAGKQ", "length": 139 }, "evidence": [ { "id": "Q3ZBK6", "url": "https://omabrowser.org/oma/group/Q3ZBK6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q54KX4-1", "protein_name": "Probable U6 snRNA-associated Sm-like protein LSm4", "gene_name": "lsm4", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLPLSLLRTGQGHQIMVELKNGETYNGLLVNCDNWMNINLKNVIRTSKDSDKFWKIQSCYIRGNTIKYISVPDEIIDLVAEEEQTLRTTYQQRNDSNRGRGRGDGFAGRGRGDASGRGRGDNSYRGGRGGGNNNSGGGDSSPAGRGRGEYRGSSRGGRGDFRGSSRGGRGGNNNSTA", "length": 177 }, "evidence": [ { "id": "Q3ZBK6", "url": "https://omabrowser.org/oma/group/Q3ZBK6/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9QXA5-1", "protein_name": "U6 snRNA-associated Sm-like protein LSm4", "gene_name": "Lsm4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPLSLLKTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVREEAAKGRGRGGPQQKQQKGRGMGGAGRGVFGGRGRGGIPGAGRGQPEKKPGRQAGKQ", "length": 137 }, "evidence": [ { "id": "Q3ZBK6", "url": "https://omabrowser.org/oma/group/Q3ZBK6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VKW8-1", "protein_name": "U6 snRNA-associated Sm-like protein LSm4", "gene_name": "CG5356", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLPLSLLKTAQSHPMLVELKNGETYNGHLVSCDSWMNINLRDVICTSKDGDRFWRMPECYIRGSTIKYLRIPDEVIDMVKEDAQAKSRNRTEMNKNRGGNSSQNQRGGRPGGGNRNNVGNRPGQGYGGAANNAMRLGGAAGQGNRLPHAAKNRK", "length": 154 }, "evidence": [ { "id": "Q3ZBK6", "url": "https://omabrowser.org/oma/group/Q3ZBK6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y4Z0-1", "protein_name": "U6 snRNA-associated Sm-like protein LSm4", "gene_name": "LSM4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLPLSLLKTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVKEEVVAKGRGRGGLQQQKQQKGRGMGGAGRGVFGGRGRGGIPGTGRGQPEKKPGRQAGKQ", "length": 139 }, "evidence": [ { "id": "Q3ZBK6", "url": "https://omabrowser.org/oma/group/Q3ZBK6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], 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splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK6" } ], "pmid": "" }, { "name": "P-body assembly", "id": "GO:0033962", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033962", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "PH domain binding", "id": "GO:0042731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042731", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK6" } ], "pmid": "" }, { "name": "U6 snRNA binding", "id": "GO:0017070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017070", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK6" } ], "pmid": "" }, { "name": 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"recommended", "evidence": [ { "id": "Q5EAB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4" } ] }, { "name": "CHID1", "type": "synonym", "evidence": [ { "id": "NP_001015515", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015515" } ] } ], "protein_names": [ { "name": "Chitinase domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q5EAB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4/entry#names_and_taxonomy" } ] }, { "name": "chitinase domain-containing protein 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001015515", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015515" } ] }, { "name": "chitinase domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001015515", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015515" } ] } ], "function": [ { "annotation": "Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro).", "evidence": [ { "database": "UniProtKB", "id": "A0A452DIF4", "url": "https://www.uniprot.org/uniprotkb/A0A452DIF4#function" }, { "database": "UniProtKB", "id": "ARBA00037756", "url": "https://www.uniprot.org/uniprotkb/ARBA00037756#function" }, { "database": "UniProtKB", "id": "G3MXK6", "url": "https://www.uniprot.org/uniprotkb/G3MXK6#function" }, { "database": "UniProtKB", "id": "A0AAF7A0P8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A0P8#function" }, { "database": "UniProtKB", "id": "Q5EAB4", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4#function" }, { "database": "UniProtKB", "id": "A0ABI0NRJ6", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRJ6#function" }, { "database": "UniProtKB", "id": "A0ABI0P064", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P064#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EAB4", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHID1", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4", "locus": { "chromosome": "29", "start_pos": 50511865, "end_pos": 50492784, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009899", "url": "https://www.ensembl.org/id/ENSBTAG00000009899" } ] } } ], "crossref": [ { "id": "Q5EAB4", "url": "https://alphafold.ebi.ac.uk/entry/Q5EAB4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009899", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009899", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02876", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02876", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504781", "url": "https://www.ncbi.nlm.nih.gov/gene/504781", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001223", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001223", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011583", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011583", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029070", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029070", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504781", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504781", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YSINERI", "url": "https://omabrowser.org/oma/group/YSINERI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIF4", "url": "https://www.orthodb.org/?gene=A0A452DIF4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3MXK6", "url": "https://www.orthodb.org/?gene=G3MXK6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q5EAB4", "url": "https://www.orthodb.org/?gene=Q5EAB4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46066", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46066", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46066:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46066:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00704", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00704", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-114608", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015515", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015515", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DIF4", "url": "https://www.uniprot.org/uniprotkb/A0A452DIF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIF4-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIF4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A0P8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A0P8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A0P8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A0P8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRJ6", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P064", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P064", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P064-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P064-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MXK6", "url": "https://www.uniprot.org/uniprotkb/G3MXK6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MXK6-1", "url": "https://www.uniprot.org/uniprotkb/G3MXK6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EAB4", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EAB4-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRVLLGTLWLTLACSSVHATLSKSDAKKAASKTLQEKTQVSGKPAQERGLVVTDLRAEDVVLEHRSYCSAKAHRKHFAGDVLGYITPWNRHGYDVAKIFGGKFTHVAPVWLQLRRHGREMFEVTGLDDVDQGWLRAVRKQAKGLRIVPRLRFEDWTYEDFDSVLDNEDEIEELSRTVVQVAKSQHFDGLVVEVWNQLLVQKHAGLIHLLTHMAEALHQARLLVFLVIPPAVAPGTNKLGMFTNTEFEQLAPVLDGFSLMTYDYSTAQPAGPNAPLPWVRACVQVLDPKSKWRSKILLGLNFYGMDYSASKDAREPIIGARYIQTLKDHRPQVVWDSQAAEHFFEYKKSRGGRHVVFYPTLKSLQERLELAQELGVGLSIWELGQGLDYFYDLL", "length": 393, "header": "sp|Q5EAB4-1|CHID1_BOVIN Isoform 1 of Chitinase domain-containing protein 1 OS=Bos taurus OX=9913 GN=CHID1 PE=2 SV=1 CANONICAL=Q5EAB4-1" }, "isoforms": [ { "isoform_ac": "A0A452DIF4-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4/entry#A0A452DIF4-1", "sequence": { "sequence": "MRVLLGTLWLTLACSSVHATLSKSDAKKAASKTLQEKTQVSGKPAQERGLVVTDLRAEDVVLEHRSYCSAKAHRKHFAGDVLGYITPWNRHGYDVAKIFGGKFTHVAPVWLQLRRHGREMFEVTGLDDVDQGWLRAVRKQAKGLRIVPRLRFEDWTYEDFDSVLDNEDEIEELSRTVVQVAKSQHFDGLVVEVWNQLLVQKHAGLIHLLTHMAEALHQARLLVFLVIPPAVAPGTNKLGMFTNTEFEQLAPVLDGFSLMTYDYSTAQPAGPNAPLPWVRACVQVLDPKSKWRSKILLGLNFYGMDYSASKDAREPIIGARYIQTLKDHRPQVVWDSQAAEHFFEYKNSLRAGAAGPTLPPPQSLQERLELAQELGVGLSIWELGQGLDYFYDLL", "length": 394, "header": "tr|A0A452DIF4-1|CHID1_BOVIN Computationally mapped isoform of Chitinase domain-containing protein 1 OS=Bos taurus OX=9913 GN=CHID1 PE=2 SV=1 CANONICAL=Q5EAB4-1" }, "locus": { "chromosome": "29", "start_pos": 50511782, "end_pos": 50496333, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013065.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013065.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013065.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013065.5" } ] } }, { "isoform_ac": "A0AAF7A0P8-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4/entry#A0AAF7A0P8-1", "sequence": { "sequence": "MEELAFRRTDKPPGTPLTSQPTCPHYPVRQAIWKVPRPLESSPARVSSWHVSASPVLWSRTPELAQRAQSCRGLWPYQPARTSPLDPEVGPCCDPPSMRVLLGTLWLTLACSSVHATLSKSDAKKAASKTLQEKTQVSGKPAQERGLVVTDLRAEDVVLEHRSYCSAKAHRKHFAGDVLGYITPWNRHGYDVAKIFGGKFTHVAPVWLQLRRHGREMFEVTGLDDVDQGWLRAVRKQAKGLRIVPRLRFEDWTYEDFDSVLDNEDEIEELSRTVVQVAKSQHFDGLVVEVWNQLLVQKHAGLIHLLTHMAEALHQARLLVFLVIPPAVAPGTNKLGMFTNTEFEQLAPVLDGFSLMTYDYSTAQPAGPNAPLPWVRACVQVLDPKSKWRSKILLGLNFYGMDYSASKDAREPIIGARYIQTLKDHRPQVVWDSQAAEHFFEYKKSRGGRHVVFYPTLKSLQERLELAQELGVGLSIWELGQGLDYFYDLL", "length": 490, "header": "tr|A0AAF7A0P8-1|CHID1_BOVIN Computationally mapped isoform of Chitinase domain-containing protein 1 OS=Bos taurus OX=9913 GN=CHID1 PE=2 SV=1 CANONICAL=Q5EAB4-1" }, "locus": { "chromosome": "29", "start_pos": 50511782, "end_pos": 50493703, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074326.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074326.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060623.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060623.2" } ] } }, { "isoform_ac": "A0ABI0NRJ6-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4/entry#A0ABI0NRJ6-1", "sequence": { "sequence": "MRVLLGTLWLTLACSSVHATLSKSDAKKAASKTLQEKTQVSGKPAQERGLVVTDLRAEDVVLEHRSYCSAKAHRKHFAGDVLGYITPWNRHGYDVAKIFGGKFTHVAPVWLQLRRHGREMFEVTGLDDVDQGWLRAVRKQAKGLRIVPRLRFEDWTYEDFDSVLDNEDEIEELSRTVVQVAKSQHFDGLVVEVWNQLLVQKHAGLIHLLTHMAEALHQARLLVFLVIPPAVAPGTNKLGMFTNTEFEQLAPVLDGFSLMTYDYSTAQPAGPNAPLPWVRACVQVHPDTEGPPAPGRVGQPGRRALLRVQEKPRREARRLLSDAEVLAGAAGAGPGAGRGAVHLGARARPGLFLRPAVGRACSQHALF", "length": 367, "header": "tr|A0ABI0NRJ6-1|A0ABI0NRJ6_BOVIN Computationally mapped isoform of Chitinase domain-containing protein 1 OS=Bos taurus OX=9913 GN=CHID1 PE=3 SV=1 CANONICAL=Q5EAB4-1" }, "locus": { "chromosome": "29", "start_pos": 50511814, "end_pos": 50496333, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151993.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151993.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106290.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106290.1" } ] } }, { "isoform_ac": "A0ABI0P064-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4/entry#A0ABI0P064-1", "sequence": { "sequence": "MRVLLGTLWLTLACSSVHATLSKSDAKKAASKTLQEKTQVSGKPAQERGLVVTDLRAEDVVLEHRSYCSAKAHRKHFAGDVLGYITPWNRHGYDVAKIFGGKFTHVAPVWLQLRRHGREMFEVTGLDDVDQGWLRAVRKQAKGLRIVPRLRFEDWTYEDFDSVLDNEDEIEELSRTVVQVAKSQHFDGLVVEVWNQLLVQKHAGLIHLLTHMAEALHQARLLVFLVIPPAVAPGTNKLGMFTNTEFEQLAPVLDGFSLMTYDYSTAQPAGPNAPLPWVRACVQVLDPKSKWRSKILLGLNFYGMDYSASKDAREPIIGARSRGGRHVVFYPTLKSLQERLELAQELGVGLSIWELGQGLDYFYDLL", "length": 366, "header": "tr|A0ABI0P064-1|A0ABI0P064_BOVIN Computationally mapped isoform of Chitinase domain-containing protein 1 OS=Bos taurus OX=9913 GN=CHID1 PE=3 SV=1 CANONICAL=Q5EAB4-1" }, "locus": { "chromosome": "29", "start_pos": 50511782, "end_pos": 50496333, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000137523.1", "url": "https://www.ensembl.org/id/ENSBTAT00000137523.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105982.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105982.1" } ] } }, { "isoform_ac": "G3MXK6-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4/entry#G3MXK6-1", "sequence": { "sequence": "MRVLLGTLWLTLACSSVHATLSKSDAKKAASKTLQEKTQVSGKPAQERGLVVTDLRAEDVVLEHRSYCSAKAHRKHFAGDVLGYITPWNRHGYDVAKIFGGKFTHVAPVWLQLRRHGREMFEVTGLDDVDQGWLRAVRKQAKGLRIVPRLRFEDWTYEDFDSVLDNEDEIEELSRTVVQVAKSQHFDGLVVEVWNQLLVQKHATNKLGMFTNTEFEQLAPVLDGFSLMTYDYSTAQPAGPNAPLPWVRACVQVLDPKSKWRSKILLGLNFYGMDYSASKDAREPIIGARYIQTLKDHRPQVVWDSQAAEHFFEYKKSRGGRHVVFYPTLKSLQERLELAQELGVGLSIWELGQGLDYFYDLL", "length": 362, "header": "tr|G3MXK6-1|CHID1_BOVIN Computationally mapped isoform of Chitinase domain-containing protein 1 OS=Bos taurus OX=9913 GN=CHID1 PE=2 SV=3 CANONICAL=Q5EAB4-1" }, "locus": { "chromosome": "29", "start_pos": 50511782, "end_pos": 50496333, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065869.4", "url": "https://www.ensembl.org/id/ENSBTAT00000065869.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054273.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054273.3" } ] } }, { "isoform_ac": "Q5EAB4-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4/entry#Q5EAB4-1", "sequence": { "sequence": "MRVLLGTLWLTLACSSVHATLSKSDAKKAASKTLQEKTQVSGKPAQERGLVVTDLRAEDVVLEHRSYCSAKAHRKHFAGDVLGYITPWNRHGYDVAKIFGGKFTHVAPVWLQLRRHGREMFEVTGLDDVDQGWLRAVRKQAKGLRIVPRLRFEDWTYEDFDSVLDNEDEIEELSRTVVQVAKSQHFDGLVVEVWNQLLVQKHAGLIHLLTHMAEALHQARLLVFLVIPPAVAPGTNKLGMFTNTEFEQLAPVLDGFSLMTYDYSTAQPAGPNAPLPWVRACVQVLDPKSKWRSKILLGLNFYGMDYSASKDAREPIIGARYIQTLKDHRPQVVWDSQAAEHFFEYKKSRGGRHVVFYPTLKSLQERLELAQELGVGLSIWELGQGLDYFYDLL", "length": 393, "header": "sp|Q5EAB4-1|CHID1_BOVIN Isoform 1 of Chitinase domain-containing protein 1 OS=Bos taurus OX=9913 GN=CHID1 PE=2 SV=1 CANONICAL=Q5EAB4-1" }, "locus": { "chromosome": "29", "start_pos": 50511782, "end_pos": 50496333, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054178.4", "url": "https://www.ensembl.org/id/ENSBTAT00000054178.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050339.2", "url": "https://www.ensembl.org/id/ENSBTAP00000050339.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EAB4", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:504781", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504781", "resource": "KEGG Pathway" }, { "id": "R-BTA-114608", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "resource": "Reactome", "description": "Platelet degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZRT1-1", "protein_name": "Chitinase domain-containing protein 1", "gene_name": "CHID1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRFLCISVCLTMICWLAEGTLSKTDAKKAATKKLEEKTLHSDKNVQDRGLVVTDPKAKDIILEHRSYCSKKTKERHFSGDVLGYITPWNSHGYDIAKIFGNKFTLISPVWLQVRRRGKERFQFTGLHDVDKGWMKDVRKNSKNIKIVPRILFDGWTYHDFESVFGSEDEIEELSQSMVLLAKNENFDGFVVEVWSQLGNQKQKELIHLLIHLSEALHEAQLKLILVIPPAVAAGTNQPGMFTKKEFDQLASAVDSFSLMTYDYSTPQRPGPNSPLPWVRACIQVLDPDSKWRNKILLGLNFYGMDYSALGALGEPILGTRYIETLKEHKPKIVWDEQIAEHYFEYKKNKGGKHAIFYPTLKSIQLRLELAKELGTGISIWELGQGLDYFYDLL", "length": 393 }, "evidence": [ { "id": "Q5EAB4", "url": "https://omabrowser.org/oma/group/Q5EAB4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RZ01-1", "protein_name": "Chitinase domain-containing protein 1", "gene_name": "CHID1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRSLLGALWLALACGSAHGTLSKSDAKKAASKTLPEKTQVAGVPVQERGLVVTDLRAEDVVLEHRSYCSAKALRKHFAGDVLGYVTPWNSHGYDIAKIFAGKFTHVAPVWLQLRRHGREMFEVTGLDDVDQGWMRAVRKQTKGLRIVPRLRFEDWTYEDFRNVLDSEDEIEELSRTVVQVAKSQRFDGFVVEVWNQLLIQKHVGLIHMLTHVVEALHQARLLAILVIPPAVAPGTNKLGVFTHKEFEQLAPLLDGFSLMTYDYSTAQQPGPNAPLSWVRACVQVLDPKSRWRSKILLGLNFYGMDYAASKDAREPIIGARYIQTLKDHRPRITWDSQAAEHVFEYKKNRGGRHIVFYPTLKSLQVRLELARELGVGLSIWELGQGLDYFYDLL", "length": 393 }, "evidence": [ { "id": "Q5EAB4", "url": "https://omabrowser.org/oma/group/Q5EAB4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q54G42-1", "protein_name": "Chitinase domain-containing protein 1", "gene_name": "chid1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKKQLILCLFLLSLLMISTFVTNADDNDNEIYEEEEDFTTNRDVKQRGLVRENVSAKQIINNYNKYFKNVDIKNFEQGNTLVYITPWNGKGYDVATKWAKKFTHISPVWHQVKFENNKVMIEGDHNIDKKWMEKVKENSDQKSKILPRFSFEGQQWGSKESFQKYIDPKLIDSLVSTVKKNNYDGLVIEGIVHINKQLRDPFLISLSEKLHSIGKEIILVIYPFRQKGQETGFGAKDFELLSNHIDGVSLMTYDFGPSGGMNAPKVWVEDNLKFLLPNGENKNSKKIFMGIPFYGYKIGENDQSDAIVGSEFISVLKQNKSKKLKFDQNTHEHIFTYKNKKNQQVSMTYPSLLFIEDRIQLANKYKVSISIWEIGQGLDYFMDLL", "length": 385 }, "evidence": [ { "id": "Q5EAB4", "url": "https://omabrowser.org/oma/group/Q5EAB4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q922Q9-1", "protein_name": "Chitinase domain-containing protein 1", "gene_name": "Chid1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWPLLHVLWLALVCGSVHTTLSKSDAKKAASKMLLEKTQFSDKPVQDRGLVVTDIKAEDVVLEHRSYCSSRARERNFAGEVLGYVTPWNSHGYDVAKVFGSKFTQISPVWLQLKRRGREMFEITGLHDVDQGWMRAVKKHAKGVRIVPRLLFEDWTYDDFRNVLDSEDEIEELSKTVAQVAKNQHFDGFVVEVWSQLLSQKHVGLIHMLTHLAEALHQARLLVILVIPPAVTPGTDQLGMFTHKEFEQLAPILDGFSLMTYDYSTSQQPGPNAPLSWIRACVQVLDPKSQWRSKILLGLNFYGMDYAASKDAREPVIGARYVQTLKDHRPRVVWDSQAAEHFFEYKKNRGGRHVVFYPTLKSLQVRLELARELGVGVSIWELGQGLDYFYDLL", "length": 393 }, "evidence": [ { "id": "Q5EAB4", "url": "https://omabrowser.org/oma/group/Q5EAB4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BWS9-1", "protein_name": "Chitinase domain-containing protein 1", "gene_name": "CHID1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRTLFNLLWLALACSPVHTTLSKSDAKKAASKTLLEKSQFSDKPVQDRGLVVTDLKAESVVLEHRSYCSAKARDRHFAGDVLGYVTPWNSHGYDVTKVFGSKFTQISPVWLQLKRRGREMFEVTGLHDVDQGWMRAVRKHAKGLHIVPRLLFEDWTYDDFRNVLDSEDEIEELSKTVVQVAKNQHFDGFVVEVWNQLLSQKRVGLIHMLTHLAEALHQARLLALLVIPPAITPGTDQLGMFTHKEFEQLAPVLDGFSLMTYDYSTAHQPGPNAPLSWVRACVQVLDPKSKWRSKILLGLNFYGMDYATSKDAREPVVGARYIQTLKDHRPRMVWDSQASEHFFEYKKSRSGRHVVFYPTLKSLQVRLELARELGVGVSIWELGQGLDYFYDLL", "length": 393 }, "evidence": [ { "id": "Q5EAB4", "url": "https://omabrowser.org/oma/group/Q5EAB4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9M159-1", "protein_name": "Chitinase domain-containing protein 1", "gene_name": "F2N1.39-01", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MARRRRSSAAESLKRRNDGYESLCQVVQQDSDRRLITIFVIFFIVIPAVSIAVYKVKFADRVIQTESSIRQKGIVKTDINFQEILTEHSKASENSTRHYDYPVLAYITPWNSKGYDMAKIFNSKFTHLSPVWYDLKSQGSGLVLEGRHNADKGWIQELRSRGNALILPRVVLEAIPGEMLNKKKLREKAISLIVTECKEMEYNGIVLESWSRWAAYGVLHDPDLRKMALKFVKQLGDALHSTSSPRNNQQHMQFMYVVGPPRSEKLQMYDFGPEDLQFLKDSVDGFSLMTYDFSNPQNPGPNAPVKWIDLTLKLLLGSSNNIDSNIARKVLLGINFYGNDFVISGDSGGGGAITGRDYLALLQKHKPTFRWDKESGEHLFMYRDDKNIKHAVFYPTLMSILLRLENARLWGIGISIWEIGQGLDYFFDLL", "length": 430 }, "evidence": [ { "id": "Q5EAB4", "url": "https://omabrowser.org/oma/group/Q5EAB4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VLS0-1", "protein_name": "Chitinase domain-containing protein 1", "gene_name": "Dmel\\CG8460", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MRAPDALLLRVALLLLLLTTVRGTLAPDSHKSKSKTKESALRGGPQDQDVFDLGLVSPEPLAKDIVSNHRGYFKETGLRRFNGTTLGYVTPWNSHGYDVAKIFAKKFDIISPVWLQIVKQGDRYAVAGTHDIDAGWLTDVRRKGKQVHNQRTVKVFPRFIFDHFTDRDIKLLLSDAQERTKVNDVLIKCCKDNGFDGLVLEVWSQLAGRIDDKILYTLVLQMAKELQKQQLRLILVIPPFRKETGHLFGEKHMDKLFKHIYAFSLMTYDFSSVQRPGANAPLYFVRKAVETIAPEGCADMTAKRAKILLGLNMYGNDYTPDGGGPITFSQYLDLVRHVKKHLTYDERDVENFFEIKNDDGRHIVFYPTLYSINERIKLAQELGTGISIWELGQGLNYFYDLF", "length": 402 }, "evidence": [ { "id": "Q5EAB4", "url": "https://omabrowser.org/oma/group/Q5EAB4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "oligosaccharide binding", "id": "GO:0070492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070492", "evidence": [ { "database": "UniProtKB", "id": "Q5EAB4", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4" } ], "pmid": "" }, { "name": "chitin binding", "id": "GO:0008061", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008061", "evidence": [ { "database": "UniProtKB", "id": "Q5EAB4", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q5EAB4", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "Q5EAB4", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "Q5EAB4", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q5EAB4", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "Q5EAB4", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "Q5EAB4", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "Q5EAB4", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4" } ], "pmid": "" }, { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "Q5EAB4", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4" } ], "pmid": "" }, { "name": "negative regulation of cytokine production involved in inflammatory response", "id": "GO:1900016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900016", "evidence": [ { "database": "UniProtKB", "id": "Q5EAB4", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EAB4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 393, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EAB4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EAB4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5EAB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB4" }, { "id": "PRU01258", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01258" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GH18", "eco_id": "ECO_0000255", "start_pos": 79, "end_pos": 393, "start_aa": "Gly", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", 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"field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZCC8-1", "uniprot_ac": "Q3ZCC8", "uniprot_id": "TPPP3_BOVIN", "mass": { "chemical_mass": 18942.0, "monoisotopic_mass": 18942.0 }, "refseq": { "ac": "NP_001029946", "name": "tubulin polymerization-promoting protein family member 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029946" }, "gene_names": [ { "name": "TPPP3", "type": "recommended", "evidence": [ { "id": "Q3ZCC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC8" } ] }, { "name": "TPPP3", "type": "synonym", "evidence": [ { "id": "NP_001029946", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029946" } ] } ], "protein_names": [ { "name": "Tubulin polymerization-promoting protein family member 3", "type": "recommended", "evidence": [ { "id": "Q3ZCC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC8/entry#names_and_taxonomy" } ] }, { "name": "tubulin polymerization-promoting protein family member 3", "type": "synonym", "evidence": [ { "id": "NP_001029946", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029946" } ] } ], "function": [ { "annotation": "Regulator of microtubule dynamic that has microtubule bundling activity (By similarity). Required for embryo implantation; possibly by regulating beta-catenin (By similarity). Also required for decidualization via regulation of beta-catenin (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC8#function" }, { "database": "UniProtKB", "id": "Q9BW30", "url": "https://www.uniprot.org/uniprotkb/Q9BW30#function" }, { "database": "UniProtKB", "id": "Q9CRB6", "url": "https://www.uniprot.org/uniprotkb/Q9CRB6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TPPP3", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC8", "locus": { "chromosome": "18", "start_pos": 34998704, "end_pos": 35005408, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019822", "url": "https://www.ensembl.org/id/ENSBTAG00000019822" } ] } } ], "crossref": [ { "id": "Q3ZCC8", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCC8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019822", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019822", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614988", "url": "https://www.ncbi.nlm.nih.gov/gene/614988", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614988", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614988", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EAFNSIC", "url": "https://omabrowser.org/oma/group/EAFNSIC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJS8", "url": "https://www.orthodb.org/?gene=A0A452DJS8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q3ZCC8", "url": "https://www.orthodb.org/?gene=Q3ZCC8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12932", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12932", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12932:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12932:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05517", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05517", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029946", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DJS8", "url": "https://www.uniprot.org/uniprotkb/A0A452DJS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJS8-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJS8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCC8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCC8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASTDVAGLEESFRKFAIHGDPKASGHEMNGKNWAKLCKDCKVADGKAVTGTDVDIVFSKVKAKSARVINYEEFKKALEELAPKRFKGKSKEEAFDAICQLVAGKEPANVGVTKAKTGGAVERLTDTSKYTGSHKERFDESGKGKGIAGRQDILDDSGYVSAYKNAGTYDAKVKK", "length": 176, "header": "sp|Q3ZCC8-1|TPPP3_BOVIN Isoform 1 of Tubulin polymerization-promoting protein family member 3 OS=Bos taurus OX=9913 GN=TPPP3 PE=1 SV=1 CANONICAL=Q3ZCC8-1" }, "isoforms": [ { "isoform_ac": "A0A452DJS8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC8/entry#A0A452DJS8-1", "sequence": { "sequence": "MAASTDVAGLEESFRKFAIHGDPKASGHEMNGKNWAKLCKDCKVADGKAVTGTDVDIVFSKVKAKSARVINYEEFKKALEELAPKRFKGKSKEEAFDAICQLVAGKEPANVGVTKAKTGGAVERLTDTSKYTGSHKERFDESGKGKGIAGRQDILDDSGYVSAYKNAAPL", "length": 170, "header": "tr|A0A452DJS8-1|TPPP3_BOVIN Computationally mapped isoform of Tubulin polymerization-promoting protein family member 3 OS=Bos taurus OX=9913 GN=TPPP3 PE=1 SV=1 CANONICAL=Q3ZCC8-1" }, "locus": { "chromosome": "18", "start_pos": 35002961, "end_pos": 34998791, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026407.5", "url": "https://www.ensembl.org/id/ENSBTAT00000026407.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026407.4", "url": "https://www.ensembl.org/id/ENSBTAP00000026407.4" } ] } }, { "isoform_ac": "Q3ZCC8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC8/entry#Q3ZCC8-1", "sequence": { "sequence": "MAASTDVAGLEESFRKFAIHGDPKASGHEMNGKNWAKLCKDCKVADGKAVTGTDVDIVFSKVKAKSARVINYEEFKKALEELAPKRFKGKSKEEAFDAICQLVAGKEPANVGVTKAKTGGAVERLTDTSKYTGSHKERFDESGKGKGIAGRQDILDDSGYVSAYKNAGTYDAKVKK", "length": 176, "header": "sp|Q3ZCC8-1|TPPP3_BOVIN Isoform 1 of Tubulin polymerization-promoting protein family member 3 OS=Bos taurus OX=9913 GN=TPPP3 PE=1 SV=1 CANONICAL=Q3ZCC8-1" }, "locus": { "chromosome": "18", "start_pos": 35002961, "end_pos": 35002201, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126221.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126221.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080601.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080601.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions.", "journal": "Biochemistry", "date": "2006", "authors": "Vincze O, Tokesi N, Olah J, Hlavanda E, Zotter A, Horvath I, Lehotzky A, Tirian L, Medzihradszky KF, Kovacs J, Orosz F, Ovadi J", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC8" } ], "reference": [ { "type": "PubMed", "id": "17105200", "url": "https://glygen.org/publication/PubMed/17105200" } ] } ], "pathway": [ { "id": "bta:614988", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614988", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1UMD5-1", "protein_name": "Tubulin polymerization-promoting protein family member 3", "gene_name": "TPPP3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAASTDVAGLEESFRKFAIHGDPKASGQEMNGKNWAKLCKDCKVADGKAVTGTDVDIVFSKVKGKSARVINYEEFKKALEELAPKRFKGKSKEEAFDAICQLVAGKEPANVGVTKAKTGGAVERLTDTSKYTGSHKERFDESGKGKGIAGRQDILDDSGYVSAYKNAGTYDAKVKK", "length": 176 }, "evidence": [ { "id": "Q3ZCC8", "url": "https://omabrowser.org/oma/group/Q3ZCC8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "E7FG48-1", "protein_name": "Tubulin polymerization-promoting protein family member 3", "gene_name": "tppp3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAESTDMDQLLNSFKKFAVHGDTKATGKELNGKNWAKLCKDCKVIDGKNVTSTDVDIVFTKVKAKTSRVITYEEFQKALEELAPKRFKGQSKEEALESIYKLIEGKEPTNIGVTKVAKTAAVDRLTDTSKYTGSHKERFDETGKGKGKGGREEIVEHTGYVGAYKNAGKYDEKTKAK", "length": 177 }, "evidence": [ { "id": "Q3ZCC8", "url": "https://omabrowser.org/oma/group/Q3ZCC8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3HZM0-1", "protein_name": "Tubulin polymerization-promoting protein family member 3", "gene_name": "Tppp3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAASTDVAGLEESFRKFAIHGDPKASGQEMNGKNWAKLCKDCKVADGKAVTGTDVDIVFSKVKAKSARVINYEEFKKALEELATKRFKGKSKEEAFDAICQLVAGKEPANLGVTKAKTGGAVDRLTDTSKYTGSHKERFDESGKGKGIAGRQDILDDSGYVSAYKNAGTYDAKVKK", "length": 176 }, "evidence": [ { "id": "Q3ZCC8", "url": "https://omabrowser.org/oma/group/Q3ZCC8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5PPN5-1", "protein_name": "Tubulin polymerization-promoting protein family member 3", "gene_name": "Tppp3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAASTDIAGLEESFRKFAIHGDPKASGQEMNGKNWAKLCKDCKVADGKAVTGTDVDIVFSKVKAKSARVINYEEFKKALEELATKRFKGKTKEEAFDAICQLIAGKEPANIGVTKAKTGGAVDRLTDTSKYTGSHKERFDESGKGKGIAGRQDILDDSGYVSAYKNAGTYDAKVKK", "length": 176 }, "evidence": [ { "id": "Q3ZCC8", "url": "https://omabrowser.org/oma/group/Q3ZCC8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9BW30-1", "protein_name": "Tubulin 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} ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VV43-1", "protein_name": "Tubulin polymerization-promoting protein homolog", "gene_name": "ringer", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSEVAAANGSPSPAPTPEVPATELAQLALEDEPKVSFSDQFKAFSKFGDSKSDGKLITLSQSDKWMKQAKVIDKKITTTDTGIHFKKFKAMKISLSDYNKFLDDLAKTKKVELSEIKQKLASCGAPGVVSVSAGKAAAAVDRLTDTSKYTGSHKERFDASGKGKGIAGRRNVVDGSGYVSGYQHKDTYDNAH", "length": 192 }, "evidence": [ { "id": "Q3ZCC8", "url": "https://omabrowser.org/oma/group/Q3ZCC8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "microtubule polymerization", "id": "GO:0046785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046785", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCC8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCC8" } ], "pmid": "" }, { "name": "embryo 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"pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCC8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 176, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCC8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCC8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", 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"title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EAC0-1", "uniprot_ac": "Q5EAC0", "uniprot_id": "S2538_BOVIN", "mass": { "chemical_mass": 33798.0, "monoisotopic_mass": 33798.0 }, "refseq": { "ac": "NP_001014905", "name": "mitochondrial glycine transporter", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014905" }, "gene_names": [ { "name": "SLC25A38", "type": "recommended", "evidence": [ { "id": "Q5EAC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC0" } ] }, { "name": "SLC25A38", "type": "synonym", "evidence": [ { "id": "NP_001014905", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014905" } ] } ], "protein_names": [ { "name": "Mitochondrial glycine transporter", "type": "recommended", "evidence": [ { "id": "Q5EAC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC0/entry#names_and_taxonomy" } ] }, { "name": "Solute carrier family 25 member 38", "type": "synonym", 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Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RT14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RT14#function" }, { "database": "HAMAP", "id": "MF_03064", "url": "https://hamap.expasy.org/signature/MF_03064" }, { "database": "UniProtKB", "id": "A0AAA9T5A6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5A6#function" }, { "database": "UniProtKB", "id": "A0AAA9TY83", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY83#function" }, { "database": "UniProtKB", "id": "Q5EAC0", "url": "https://www.uniprot.org/uniprotkb/Q5EAC0#function" } ] }, { "annotation": "Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RT14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RT14#function" }, { "database": "UniProtKB", "id": "ARBA00034083", "url": "https://www.uniprot.org/uniprotkb/ARBA00034083#function" }, { "database": "UniProtKB", "id": "A0AAA9T5A6", "url": 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"https://www.ensembl.org/id/ENSBTAG00000022721" } ] } } ], "crossref": [ { "id": "Q5EAC0", "url": "https://alphafold.ebi.ac.uk/entry/Q5EAC0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022721", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022721", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512325", "url": "https://www.ncbi.nlm.nih.gov/gene/512325", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030847", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030847", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512325", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512325", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WGIYEEL", "url": "https://omabrowser.org/oma/group/WGIYEEL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EAC0", "url": "https://www.orthodb.org/?gene=Q5EAC0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46181", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46181", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46181:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46181:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00153", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00153", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014905", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "70715", "url": "https://www.rhea-db.org/rhea/70715", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RT14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RT14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RT14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RT14-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5A6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5A6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5A6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5A6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY83", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY83-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY83-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EAC0", "url": "https://www.uniprot.org/uniprotkb/Q5EAC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EAC0-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAC0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIQKSRPALLQHQDVGDRVETLMLQPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSAHGSRRVGMLALLLNVVRTESPLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESIILGAGSRSVAGVCMSPITVIKTRYESGRYGYESVYAALRSICHSEGFRGLFSGLTATLLRDAPFSGIYLMFYSQTKNVVLHRTDQLDAVLVPVVNFSCGIFAGILASLVTQPADVIKTHMQLFPMKFRWIGQSVTLIFKDYGLRGFFQGSVPRALRRTLMAAMAWTVYEEMMAKMGLKS", "length": 306, "header": "sp|Q5EAC0-1|S2538_BOVIN Isoform 1 of Mitochondrial glycine transporter OS=Bos taurus OX=9913 GN=SLC25A38 PE=2 SV=2 CANONICAL=Q5EAC0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RT14-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAC0/entry#A0AAA9RT14-1", "sequence": { "sequence": "MHRRGQLQPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSAHGSRRVGMLALLLNVVRTESPLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESIILGAGSRSVAGVCMSPITVIKTRYESGRYGYESVYAALRSICHSEGFRGLFSGLTATLLRDAPFSGIYLMFYSQTKNVVLHRTDQLDAVLVPVVNFSCGIFAGILASLVTQPADVIKTHMQLFPMKFRWIGQSVTLIFKDYGLRGFFQGSVPRALRRTLMAAMAWTVYEEMMAKMGLKS", "length": 289, "header": "tr|A0AAA9RT14-1|S2538_BOVIN Computationally mapped isoform of Mitochondrial glycine transporter OS=Bos taurus OX=9913 GN=SLC25A38 PE=2 SV=1 CANONICAL=Q5EAC0-1" }, "locus": { "chromosome": "22", "start_pos": 12659551, "end_pos": 12648874, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098489.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098489.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075922.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075922.1" } ] } }, { "isoform_ac": "A0AAA9T5A6-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAC0/entry#A0AAA9T5A6-1", "sequence": { "sequence": "MIQKSRPALLQHQDVGDRVETLMSEAGHRQLQPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSAHGSRRVGMLALLLNVVRTESPLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESIILGAGSRSVAGVCMSPITVIKTRYESGRYGYESVYAALRSICHSEGFRGLFSGLTATLLRDAPFSGIYLMFYSQTKNVVLHRTDQLDAVLVPVVNFSCGIFAGILASLVTQPADVIKTHMQLFPMKFRWIGQSVTLIFKDYGLRGFFQGSVPRALRRTLMAAMAWTVYEEMMAKMGLKS", "length": 313, "header": "tr|A0AAA9T5A6-1|S2538_BOVIN Computationally mapped isoform of Mitochondrial glycine transporter OS=Bos taurus OX=9913 GN=SLC25A38 PE=2 SV=1 CANONICAL=Q5EAC0-1" }, "locus": { "chromosome": "22", "start_pos": 12659551, "end_pos": 12646036, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128944.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128944.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093007.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093007.1" } ] } }, { "isoform_ac": "A0AAA9TY83-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAC0/entry#A0AAA9TY83-1", "sequence": { "sequence": "GHRQLQPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSAHGSRRVGMLALLLNVVRTESPLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESIILGAGSRSVAGVCMSPITVIKTRYESGRYGYESVYAALRSICHSEGFRGLFSGLTATLLRDAPFSGIYLMFYSQTKNVVLHHQLDAVLVPVVNFSCGIFAGILASLVTQPADVIKTHMQLFPMKFRWIGQSVTLIFKDYGLRGFFQGSVPRALRRTLMAAMAWTVYEEMMAKMGLKS", "length": 285, "header": "tr|A0AAA9TY83-1|S2538_BOVIN Computationally mapped isoform of Mitochondrial glycine transporter OS=Bos taurus OX=9913 GN=SLC25A38 PE=2 SV=1 CANONICAL=Q5EAC0-1" }, "locus": { "chromosome": "22", "start_pos": 12659551, "end_pos": 12653298, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129189.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129189.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101626.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101626.1" } ] } }, { "isoform_ac": "Q5EAC0-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAC0/entry#Q5EAC0-1", "sequence": { "sequence": "MIQKSRPALLQHQDVGDRVETLMLQPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSAHGSRRVGMLALLLNVVRTESPLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESIILGAGSRSVAGVCMSPITVIKTRYESGRYGYESVYAALRSICHSEGFRGLFSGLTATLLRDAPFSGIYLMFYSQTKNVVLHRTDQLDAVLVPVVNFSCGIFAGILASLVTQPADVIKTHMQLFPMKFRWIGQSVTLIFKDYGLRGFFQGSVPRALRRTLMAAMAWTVYEEMMAKMGLKS", "length": 306, "header": "sp|Q5EAC0-1|S2538_BOVIN Isoform 1 of Mitochondrial glycine transporter OS=Bos taurus OX=9913 GN=SLC25A38 PE=2 SV=2 CANONICAL=Q5EAC0-1" }, "locus": { "chromosome": "22", "start_pos": 12659551, "end_pos": 12646036, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020606.8", "url": "https://www.ensembl.org/id/ENSBTAT00000020606.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020606.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020606.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC0", "url": "https://www.uniprot.org/uniprotkb/Q5EAC0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:512325", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512325", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YS54-1", "protein_name": "Mitochondrial glycine transporter", "gene_name": "SLC25A38", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPGREAEMHPVLKAFVCGSISGTCSTLLFQPLDLLKTRLQTLQPTVGGSGRAGMVTVLFRVVRTESLLGLWKGVSPSFARCIPGVGIYFSTLYTMKQKFLGDRSPTALESVFLGATARAISGICMLPVTVVKTRYESGRFGYGSVYGALRSIYQTEGARGMFSGLTATLLRDAPFSGIYLMFYTQTKKLTPQDQLDPVLMPVVNFGCGIFAGILASLATQPADVIKTHMQLSPEKYRRTSQAIAFIYKDFGLVGFFRGGVPRALRRTLMAAMAWTVYEQMMEKMGLKS", "length": 288 }, "evidence": [ { "id": "Q5EAC0", "url": "https://omabrowser.org/oma/group/Q5EAC0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q07534-1", "protein_name": "Mitochondrial glycine transporter", "gene_name": "HEM25", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTEQATKPRNSSHLIGGFFGGLTSAVALQPLDLLKTRIQQDKKATLWKNLKEIDSPLQLWRGTLPSALRTSIGSALYLSCLNLMRSSLAKRRNAVPSLTNDSNIVYNKSSSLPRLTMYENLLTGAFARGLVGYITMPITVIKVRYESTLYNYSSLKEAITHIYTKEGLFGFFRGFGATCLRDAPYAGLYVLLYEKSKQLLPMVLPSRFIHYNPEGGFTTYTSTTVNTTSAVLSASLATTVTAPFDTIKTRMQLEPSKFTNSFNTFTSIVKNENVLKLFSGLSMRLARKAFSAGIAWGIYEELVKRFM", "length": 307 }, "evidence": [ { "id": "Q5EAC0", "url": "https://omabrowser.org/oma/group/Q5EAC0/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q499U1-1", "protein_name": "Mitochondrial glycine transporter", "gene_name": "Slc25a38", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGVSAEPRSLSVARAGLASPVIEKARSALLPSQDVEDTVETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDVGPRRVGMLSVFLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSSKQYFLRGHPPTALESVILGMGSRSVAGVCMSPITVVKTRYESGAYSYESVYAALRSIYCSEGSRGLFRGLTATLLRDAPFSGLYLMFYSQTRATVLHGADELDAALMPLVNFSCGVFAGILASLVTQPADVIKTHMQLSTVKCQCIGQVATLILKTHGLRGFFHGSVPRALRRTLMAAMAWTVYEEMMAKMGLKS", "length": 326 }, "evidence": [ { "id": "Q5EAC0", "url": "https://omabrowser.org/oma/group/Q5EAC0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91XD8-1", "protein_name": "Mitochondrial glycine transporter", "gene_name": "Slc25a38", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGVSAEPRSLSVAGAGLASPVIEKARSALLQSQDVEDTVETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQALQPSDLGPRRVGMLAVFLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSSKQYFLRGHPPTALESVILGMGSRSVAGVCMSPITVIKTRYESGTYSYESIYAALRSIYCSEGHRGLFRGLTATLLRDAPFSGLYLMFYSQTRTAVLHGTAQLDAALIPLINFSCGIFAGVLASLVTQPADVIKTHMQLSPVKFQWIGQAATLIFKNHGLRGFFHGSVPRALRRTLMAAMAWTVYEEMMARMGLKS", "length": 326 }, "evidence": [ { "id": "Q5EAC0", "url": "https://omabrowser.org/oma/group/Q5EAC0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96DW6-1", "protein_name": "Mitochondrial glycine transporter", "gene_name": "SLC25A38", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIQNSRPSLLQPQDVGDTVETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESVMLGVGSRSVAGVCMSPITVIKTRYESGKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQLYPLKFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEMMAKMGLKS", "length": 304 }, "evidence": [ { "id": "Q5EAC0", "url": "https://omabrowser.org/oma/group/Q5EAC0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "glycine transmembrane transporter activity", "id": "GO:0015187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015187", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC0", "url": "https://www.uniprot.org/uniprotkb/Q5EAC0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC0", "url": "https://www.uniprot.org/uniprotkb/Q5EAC0" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC0", "url": "https://www.uniprot.org/uniprotkb/Q5EAC0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "erythrocyte differentiation", "id": "GO:0030218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030218", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC0", "url": "https://www.uniprot.org/uniprotkb/Q5EAC0" } ], "pmid": "" }, { "name": "glycine import into mitochondrion", "id": "GO:1904983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904983", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC0", "url": "https://www.uniprot.org/uniprotkb/Q5EAC0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "70715", "name": "", "equation": "glycine(in) = glycine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "70715", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70715" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EAC0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 306, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EAC0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EAC0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 222, "end_pos": 224 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA00-1", "uniprot_ac": "Q5EA00", "uniprot_id": "SMAP2_BOVIN", "mass": { "chemical_mass": 46900.0, "monoisotopic_mass": 46900.0 }, "refseq": { "ac": "NP_001069138", "name": "stromal membrane-associated protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069138" }, "gene_names": [ { "name": "SMAP2", "type": "recommended", "evidence": [ { "id": "Q5EA00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA00" } ] }, { "name": "SMAP1L", "type": "synonym", "evidence": [ { "id": "NP_001069138", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069138" }, { "id": "Q5EA00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA00" } ] }, { "name": "SMAP2", "type": "synonym", "evidence": [ { "id": "NP_001069138", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069138" } ] } ], "protein_names": [ { "name": "Stromal membrane-associated protein 2", "type": "recommended", "evidence": [ { "id": "Q5EA00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA00/entry#names_and_taxonomy" } ] }, { "name": "Stromal membrane-associated protein 1-like", "type": "synonym", "evidence": [ { "id": "Q5EA00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA00/entry#names_and_taxonomy" } ] }, { "name": "stromal membrane-associated GTPase-activating protein 2", "type": "synonym", "evidence": [ { "id": "NP_001069138", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069138" } ] }, { "name": "stromal membrane-associated protein 2", "type": "synonym", "evidence": [ { "id": "NP_001069138", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069138" } ] } ], "function": [ { "annotation": "GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5EA00", "url": "https://www.uniprot.org/uniprotkb/Q5EA00#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA00", "url": "https://www.uniprot.org/uniprotkb/Q5EA00" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMAP2", "url": "https://www.uniprot.org/uniprotkb/Q5EA00", "locus": { "chromosome": "3", "start_pos": 105710017, "end_pos": 105757346, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021922", "url": "https://www.ensembl.org/id/ENSBTAG00000021922" } ] } } ], "crossref": [ { "id": "Q5EA00", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA00", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021922", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021922", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08859", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08859", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514465", "url": "https://www.ncbi.nlm.nih.gov/gene/514465", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037278", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037278", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038508", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038508", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051718", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051718", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514465", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514465", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MMGYGQS", "url": "https://omabrowser.org/oma/group/MMGYGQS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EA00", "url": "https://www.orthodb.org/?gene=Q5EA00", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45705", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45705", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45705:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45705:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069138", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RTE3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTE3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTE3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNX2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPP2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPP2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV84-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA00", "url": "https://www.uniprot.org/uniprotkb/Q5EA00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA00-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA00-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTGKSVKDVDRYQAVLANLLLEEDNKFCADCQSKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTQEQIQCMQEMGNGKANRLYEAYLPETFRRPQIDHAVEGFIRDKYEKKKYMDRSLDINAFRKEKDNKWKRGSEPAPEKKMEPVVFEKVKMPQKKEDPQLPRKTSPKSKAPVVDLLGLDAPVSCSIANGKTSNTLEKDLDLLASVSSPSSSVSRKVVGSMPTPGSAGSVPENLNLFPEPGSKSEETSKKQLSKDSILSLYGSQTPQMPTQAMFMAPAQMAYPTAYPSFPGVTPPNSLMGSMMPPPVGMVAQPGASGMVAPMAMPAGYMGGMQASMMGVPNGMMTTQQASYMAGMAAMPQTMYGVQPAQQLQWNLTQMTQQMAGMNFCGTNGMLSYGQSMNGGNGQAANQTLSPQMWK", "length": 429, "header": "sp|Q5EA00-1|SMAP2_BOVIN Isoform 1 of Stromal membrane-associated protein 2 OS=Bos taurus OX=9913 GN=SMAP2 PE=2 SV=1 CANONICAL=Q5EA00-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RTE3-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA00/entry#A0AAA9RTE3-1", "sequence": { "sequence": "MVFKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTQEQIQCMQEMGNGKANRLYEAYLPETFRRPQIDHAVEGFIRDKYEKKKYMDRSLDINAFRKEKDNKWKRGSEPAPEKKMEPVVFEKVKMPQKKEDPQLPRKTSPKSKAPVVDLLGLDAPVSCSIANGKTSNTLEKDLDLLASVSSPSSSVSRKVVGSMPTPGSAGSVPENLNLFPEPGSKSEETSKKQLSKDSILSLYGSQTPQMPTQAMFMAPAQMAYPTAYPSFPGVTPPNSLMGSMMPPPVGMVAQPGASGMVAPMAMPAGYMGGMQASMMGVPNGMMTTQQASYMAGMAAMPQTMYGVQPAQQLQWNLTQMTQQMAGMNFCGTNGMLSYGQSMNGGNGQAANQTLSPQMWK", "length": 399, "header": "tr|A0AAA9RTE3-1|SMAP2_BOVIN Computationally mapped isoform of Stromal membrane-associated protein 2 OS=Bos taurus OX=9913 GN=SMAP2 PE=2 SV=1 CANONICAL=Q5EA00-1" }, "locus": { "chromosome": "3", "start_pos": 105756412, "end_pos": 105711261, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134731.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134731.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075138.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075138.1" } ] } }, { "isoform_ac": "A0AAA9RVZ8-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA00/entry#A0AAA9RVZ8-1", "sequence": { "sequence": "MQRVLRIAALKRASSDQLALGERGDHRTHSLLCCCCCPVPSSRPSLQPHGLKSARPLCSSPSPEVCRSSLSSILDLKNILSYSEGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTQEQIQCMQEMGNGKANRLYEAYLPETFRRPQIDHAVEGFIRDKYEKKKYMDRSLDINAFRKEKDNKWKRGSEPAPEKKMEPVVFEKVKMPQKKEDPQLPRKTSPKSKAPVVDLLGLDAPVSCSIANGKTSNTLEKDLDLLASVSSPSSSVSRKVVGSMPTPGSAGSVPENLNLFPEPGSKSEETSKKQLSKDSILSLYGSQTPQMPTQAMFMAPAQMAYPTAYPSFPGVTPPNSLMGSMMPPPVGMVAQPGASGMVAPMAMPAGYMGGMQASMMGVPNGMMTTQQASYMAGMAAMPQTMYGVQPAQQLQWNLTQMTQQMAGMNFCGTNGMLSYGQSMNGGNGQAANQTLSPQMWK", "length": 479, "header": "tr|A0AAA9RVZ8-1|SMAP2_BOVIN Computationally mapped isoform of Stromal membrane-associated protein 2 OS=Bos taurus OX=9913 GN=SMAP2 PE=2 SV=1 CANONICAL=Q5EA00-1" }, "locus": { "chromosome": "3", "start_pos": 105748508, "end_pos": 105711261, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096369.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096369.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077570.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077570.1" } ] } }, { "isoform_ac": "A0AAA9SNX2-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA00/entry#A0AAA9SNX2-1", "sequence": { "sequence": "MQRVLRIAALKRGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTQEQIQCMQEMGNGKANRLYEAYLPETFRRPQIDHAVEGFIRDKYEKKKYMDRSLDINAFRKEKDNKWKRGSEPAPEKKMEPVVFEKVKMPQKKEDPQLPRKTSPKSKAPVVDLLGLDAPVSCSIANGKTSNTLEKDLDLLASVSSPSSSVSRKVVGSMPTPGSAGSVPENLNLFPEPGSKSEETSKKQLSKDSILSLYGSQTPQMPTQAMFMAPAQMAYPTAYPSFPGVTPPNSLMGSMMPPPVGMVAQPGASGMVAPMAMPAGYMGGMQASMMGVPNGMMTTQQASYMAGMAAMPQTMYGVQPAQQLQWNLTQMTQQMAGMNFCGTNGMLSYGQSMNGGNGQAANQTLSPQMWK", "length": 407, "header": "tr|A0AAA9SNX2-1|SMAP2_BOVIN Computationally mapped isoform of Stromal membrane-associated protein 2 OS=Bos taurus OX=9913 GN=SMAP2 PE=2 SV=1 CANONICAL=Q5EA00-1" }, "locus": { "chromosome": "3", "start_pos": 105748508, "end_pos": 105711261, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104022.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104022.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087064.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087064.1" } ] } }, { "isoform_ac": "A0AAA9TPP2-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA00/entry#A0AAA9TPP2-1", "sequence": { "sequence": "MNLHTQAQALGFPGAESKKWRKMILIPVQLVISSMNLGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTQEQIQCMQEMGNGKANRLYEAYLPETFRRPQIDHAVEGFIRDKYEKKKYMDRSLDINAFRKEKDNKWKRGSEPAPEKKMEPVVFEKVKMPQKKEDPQLPRKTSPKSKAPVVDLLGLDAPVSCSIANGKTSNTLEKDLDLLASVSSPSSSVSRKVVGSMPTPGSAGSVPENLNLFPEPGSKSEETSKKQLSKDSILSLYGSQTPQMPTQAMFMAPAQMAYPTAYPSFPGVTPPNSLMGSMMPPPVGMVAQPGASGMVAPMAMPAGYMGGMQASMMGVPNGMMTTQQASYMAGMAAMPQTMYGVQPAQQLQWNLTQMTQQMAGMNFCGTNGMLSYGQSMNGGNGQAANQTLSPQMWK", "length": 432, "header": "tr|A0AAA9TPP2-1|SMAP2_BOVIN Computationally mapped isoform of Stromal membrane-associated protein 2 OS=Bos taurus OX=9913 GN=SMAP2 PE=2 SV=1 CANONICAL=Q5EA00-1" }, "locus": { "chromosome": "3", "start_pos": 105743644, "end_pos": 105711261, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121216.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121216.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098987.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098987.1" } ] } }, { "isoform_ac": "A0AAA9TV84-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA00/entry#A0AAA9TV84-1", "sequence": { "sequence": "MEKVDGARFSQNDVLQVTAHVELFVSYRPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTQEQIQCMQEMGNGKANRLYEAYLPETFRRPQIDHAVEGFIRDKYEKKKYMDRSLDINAFRKEKDNKWKRGSEPAPEKKMEPVVFEKVKMPQKKEDPQLPRKTSPKSKAPVVDLLGLDAPVSCSIANGKTSNTLEKDLDLLASVSSPSSSVSRKVVGSMPTPGSAGSVPENLNLFPEPGSKSEETSKKQLSKDSILSLYGSQTPQMPTQAMFMAPAQMAYPTAYPSFPGVTPPNSLMGSMMPPPVGMVAQPGASGMVAPMAMPAGYMGGMQASMMGVPNGMMTTQQASYMAGMAAMPQTMYGVQPAQQLQWNLTQMTQQMAGMNFCGTNGMLSYGQSMNGGNGQAANQTLSPQMWK", "length": 422, "header": "tr|A0AAA9TV84-1|SMAP2_BOVIN Computationally mapped isoform of Stromal membrane-associated protein 2 OS=Bos taurus OX=9913 GN=SMAP2 PE=2 SV=2 CANONICAL=Q5EA00-1" }, "locus": { "chromosome": "3", "start_pos": 105741334, "end_pos": 105711261, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110908.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110908.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101309.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101309.1" } ] } }, { "isoform_ac": "Q5EA00-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA00/entry#Q5EA00-1", "sequence": { "sequence": "MTGKSVKDVDRYQAVLANLLLEEDNKFCADCQSKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTQEQIQCMQEMGNGKANRLYEAYLPETFRRPQIDHAVEGFIRDKYEKKKYMDRSLDINAFRKEKDNKWKRGSEPAPEKKMEPVVFEKVKMPQKKEDPQLPRKTSPKSKAPVVDLLGLDAPVSCSIANGKTSNTLEKDLDLLASVSSPSSSVSRKVVGSMPTPGSAGSVPENLNLFPEPGSKSEETSKKQLSKDSILSLYGSQTPQMPTQAMFMAPAQMAYPTAYPSFPGVTPPNSLMGSMMPPPVGMVAQPGASGMVAPMAMPAGYMGGMQASMMGVPNGMMTTQQASYMAGMAAMPQTMYGVQPAQQLQWNLTQMTQQMAGMNFCGTNGMLSYGQSMNGGNGQAANQTLSPQMWK", "length": 429, "header": "sp|Q5EA00-1|SMAP2_BOVIN Isoform 1 of Stromal membrane-associated protein 2 OS=Bos taurus OX=9913 GN=SMAP2 PE=2 SV=1 CANONICAL=Q5EA00-1" }, "locus": { "chromosome": "3", "start_pos": 105756946, "end_pos": 105711261, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029227.6", "url": "https://www.ensembl.org/id/ENSBTAT00000029227.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029227.5", "url": "https://www.ensembl.org/id/ENSBTAP00000029227.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 234, "start_aa": "Thr", "end_pos": 234, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr234", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 127, "end_pos": 127, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA00", "url": "https://www.uniprot.org/uniprotkb/Q5EA00" } ], "site_lbl": "Ser127" }, { "start_pos": 219, "end_pos": 219, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA00", "url": "https://www.uniprot.org/uniprotkb/Q5EA00" } ], "site_lbl": "Ser219" }, { "start_pos": 223, "end_pos": 223, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA00", "url": "https://www.uniprot.org/uniprotkb/Q5EA00" } ], "site_lbl": "Ser223" }, { "start_pos": 225, "end_pos": 225, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA00", "url": "https://www.uniprot.org/uniprotkb/Q5EA00" } ], "site_lbl": "Ser225" }, { "start_pos": 231, "end_pos": 231, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA00", "url": "https://www.uniprot.org/uniprotkb/Q5EA00" } ], "site_lbl": "Ser231" }, { "start_pos": 240, "end_pos": 240, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA00", "url": "https://www.uniprot.org/uniprotkb/Q5EA00" } ], "site_lbl": "Ser240" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA00", "url": "https://www.uniprot.org/uniprotkb/Q5EA00" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:514465", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514465", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8J8XM71-1", "protein_name": "Small ArfGAP2", "gene_name": "Smap2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTGKSVKDVDRYQAVLANLLLEEDNKFCADCQSKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTQEQIQCMQEMGNGKANRLYEAYLPETFRRPQIDPFFDSSLISVCRAVEGFIRDKYEKKKYMDRSLDINVLRKEKDDKWKRGSEPAPEKKMEPVVFEKVKMPQKKEDAQLPRKSSPKSAAPVMDLLGLDAPVACSIANSKTSNALEKDLDLLASVPSPSSVSRKAVGSMPTAGSAGSVPENLNLFPEPGSKSEETGKKQLSKDSILSLYGSQTPQMPAQAMFMAPAQMAYPTAYPSFPGVTPPNSIMGSMMPPPVGMVAHPGASGMVTPMAMPAGYMGGMQASMAGVPSGMMTTQQAGYMASMAAMPQTVYGVQPAQQLQWNLTQMTQQMAGMNFYGANGMMSYGQSMGGGNGQAANQTLSPQMWK", "length": 439 }, "evidence": [ { "id": "Q5EA00", "url": "https://omabrowser.org/oma/group/Q5EA00/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5F413-1", "protein_name": "Stromal membrane-associated protein 2", "gene_name": "SMAP2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTGKSVRDVERYQAVLGSLLSEEENKYCADCQAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTQEQIQCMQEMGNGKANRLYEAFLPENFRRPQTDQAVEGFIRDKYEKKKYMDRSIDINTFRKEKDDKWKKSNEPVSERKLEPIVFEKVKMPQKKEETQQSRKSSPKSTEPVIDLLGLDAPVPSTLTNGRPCSLEKDLDLFASVGLNSDSRKVSGSMPTSGSAGSVPENLNLFPEPGGKGEEAGKKQLSKDSILSLYGSQTPQLPAQGAMFMAPAQMAYPAAAYTSFPGVPPSSSMMGGMMAPSVGVMAQHGAAGMVTPMAIPAGYVGNVQAAVIGVPNGMMAAQQAGYVAGMAAVPQPVYGVQPAQQLQWNITQMTQQMAGMNFYGANGVMGYGQSMGGGGAQGSNQSLSTQLWK", "length": 428 }, "evidence": [ { "id": "Q5EA00", "url": "https://omabrowser.org/oma/group/Q5EA00/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q7TN29-1", "protein_name": "Stromal membrane-associated protein 2", "gene_name": "Smap2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTGKSVKDVDRYQAVLANLLLEEDNKFCADCQSKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTQEQIQCMQEMGNGKANRLYEAYLPETFRRPQIDPAVEGFIRDKYEKKKYMDRSLDINVLRKEKDDKWKRGNEPAPEKKMEPVVFEKVKMPQKKEDAQLPRKSSPKSAAPVMDLLGLDAPVACSIANSKTSNALEKDLDLLASVPSPSSVSRKAVGSMPTAGSAGSVPENLNLFPEPGSKSEETGKKQLSKDSILSLYGSQTPQMPAQAMFMAPAQMAYPTAYPSFPGVTPPNSIMGGMVPPPVGMVAQPGASGMLTPMAMPAGYMGGMQASMMGVPNGMMTTQQAGYMASMAAMPQTVYGVQPAQQLQWNLTQMTQQMAGMNFYGANGMMNYGQSMGGGNGQAANQTLSPQMWK", "length": 428 }, "evidence": [ { "id": "Q5EA00", "url": "https://omabrowser.org/oma/group/Q5EA00/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WU79-1", "protein_name": "Stromal membrane-associated protein 2", "gene_name": "SMAP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTGKSVKDVDRYQAVLANLLLEEDNKFCADCQSKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTQEQIQCMQEMGNGKANRLYEAYLPETFRRPQIDPAVEGFIRDKYEKKKYMDRSLDINAFRKEKDDKWKRGSEPVPEKKLEPVVFEKVKMPQKKEDPQLPRKSSPKSTAPVMDLLGLDAPVACSIANSKTSNTLEKDLDLLASVPSPSSSGSRKVVGSMPTAGSAGSVPENLNLFPEPGSKSEEIGKKQLSKDSILSLYGSQTPQMPTQAMFMAPAQMAYPTAYPSFPGVTPPNSIMGSMMPPPVGMVAQPGASGMVAPMAMPAGYMGGMQASMMGVPNGMMTTQQAGYMAGMAAMPQTVYGVQPAQQLQWNLTQMTQQMAGMNFYGANGMMNYGQSMSGGNGQAANQTLSPQMWK", "length": 429 }, "evidence": [ { "id": "Q5EA00", "url": "https://omabrowser.org/oma/group/Q5EA00/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "Q5EA00", "url": "https://www.uniprot.org/uniprotkb/Q5EA00" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q5EA00", "url": "https://www.uniprot.org/uniprotkb/Q5EA00" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5EA00", "url": "https://www.uniprot.org/uniprotkb/Q5EA00" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5EA00", "url": "https://www.uniprot.org/uniprotkb/Q5EA00" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 385, "end_pos": 387, "annotation": "n_glycosylation_sequon" }, { "start_pos": 420, "end_pos": 422, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA00-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 429, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA00-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA00" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5EA00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA00" }, { "id": "PRU00288", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00288" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Arf-GAP", "eco_id": "ECO_0000255", "start_pos": 13, "end_pos": 137, "start_aa": "Gln", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 234 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 127, 219, 223, 225, 231, 240 ], "sequon_annotation_sites": [ { "start_pos": 385, "end_pos": 387 }, { "start_pos": 420, "end_pos": 422 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBL4-1", "uniprot_ac": "Q3ZBL4", "uniprot_id": "LZTL1_BOVIN", "mass": { "chemical_mass": 34577.0, "monoisotopic_mass": 34577.0 }, "refseq": { "ac": "NP_001029597", "name": "leucine zipper transcription factor-like protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029597" }, "gene_names": [ { "name": "LZTFL1", "type": "recommended", "evidence": [ { "id": "Q3ZBL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL4" } ] }, { "name": "LZTFL1", "type": "synonym", "evidence": [ { "id": "NP_001029597", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029597" } ] } ], "protein_names": [ { "name": "Leucine zipper transcription factor-like protein 1", "type": "recommended", "evidence": [ { "id": "Q3ZBL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL4/entry#names_and_taxonomy" } ] }, { "name": "leucine zipper transcription factor-like protein 1", "type": "synonym", "evidence": [ { "id": "NP_001029597", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029597" } ] } ], "function": [ { "annotation": "Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RVK0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVK0#function" }, { "database": "UniProtKB", "id": "ARBA00024898", "url": "https://www.uniprot.org/uniprotkb/ARBA00024898#function" }, { "database": "UniProtKB", "id": "Q3ZBL4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LZTFL1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL4", "locus": { "chromosome": "22", "start_pos": 53489385, "end_pos": 53471323, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001484", "url": "https://www.ensembl.org/id/ENSBTAG00000001484" } ] } } ], "crossref": [ { "id": "Q3ZBL4", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBL4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001484", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001484", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512570", "url": "https://www.ncbi.nlm.nih.gov/gene/512570", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512570", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512570", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QMEGTTA", "url": "https://omabrowser.org/oma/group/QMEGTTA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBL4", "url": "https://www.orthodb.org/?gene=Q3ZBL4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21635", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21635", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21635:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21635:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15294", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15294", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5620922", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620922", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029597", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RVK0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVK0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVK0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBL4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBL4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAELGLNEHHQNEVINYMRFARSKRGLRLKTVDSCFQDLKESRLVEETFTVDEVSEVLNGLQAVVHSEVESELINTAYTNVLLLRQLFSQAEKWYLKLQTDISELENRELLEQVAEFEKAEFTSSNKKSIIDSMKPKLAPLHEGGAAELLNKEIIRLQEENEKLKSRLKTIESQATDALDEKSKLERALQDLQLEHGSQKDFIKAQDLSDLENTVAALKSEFQKTLNDQTENQKSLEENLATAKHDLLRVQEQLSMAEKELEKKFQQTAAFRNMKEILTKKNDQIKDLRKRLAKYEPED", "length": 299, "header": "sp|Q3ZBL4-1|LZTL1_BOVIN Isoform 1 of Leucine zipper transcription factor-like protein 1 OS=Bos taurus OX=9913 GN=LZTFL1 PE=2 SV=1 CANONICAL=Q3ZBL4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RVK0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL4/entry#A0AAA9RVK0-1", "sequence": { "sequence": "MAELGLNEHHQNEVINYMRFARSKRGLRLKTVDSCFQDLKESRLVEETFTVDEVSEVLNGLQAVVHSEVESELINTAYTNVLLLRQLFSQAEKWYLKLQTDISELENRELLEQVAEFEKAEFTSSNKKSIIDSMKPKLAPLHEGGAAELLNKATDALDEKSKLERALQDLQLEHGSQKDFIKAQDLSDLENTVAALKSEFQKTLNDQTENQKSLEENLATAKHDLLRVQEQLSMAEKELEKKFQQTAAFRNMKEILTKKNDQIKDLRKRLAKYEPED", "length": 277, "header": "tr|A0AAA9RVK0-1|LZTL1_BOVIN Computationally mapped isoform of Leucine zipper transcription factor-like protein 1 OS=Bos taurus OX=9913 GN=LZTFL1 PE=2 SV=1 CANONICAL=Q3ZBL4-1" }, "locus": { "chromosome": "22", "start_pos": 53488965, "end_pos": 53471453, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122915.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122915.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076353.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076353.1" } ] } }, { "isoform_ac": "Q3ZBL4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL4/entry#Q3ZBL4-1", "sequence": { "sequence": "MAELGLNEHHQNEVINYMRFARSKRGLRLKTVDSCFQDLKESRLVEETFTVDEVSEVLNGLQAVVHSEVESELINTAYTNVLLLRQLFSQAEKWYLKLQTDISELENRELLEQVAEFEKAEFTSSNKKSIIDSMKPKLAPLHEGGAAELLNKEIIRLQEENEKLKSRLKTIESQATDALDEKSKLERALQDLQLEHGSQKDFIKAQDLSDLENTVAALKSEFQKTLNDQTENQKSLEENLATAKHDLLRVQEQLSMAEKELEKKFQQTAAFRNMKEILTKKNDQIKDLRKRLAKYEPED", "length": 299, "header": "sp|Q3ZBL4-1|LZTL1_BOVIN Isoform 1 of Leucine zipper transcription factor-like protein 1 OS=Bos taurus OX=9913 GN=LZTFL1 PE=2 SV=1 CANONICAL=Q3ZBL4-1" }, "locus": { "chromosome": "22", "start_pos": 53488965, "end_pos": 53471453, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001942.8", "url": "https://www.ensembl.org/id/ENSBTAT00000001942.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001942.6", "url": "https://www.ensembl.org/id/ENSBTAP00000001942.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:512570", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512570", "resource": "KEGG Pathway" }, { "id": "R-BTA-5620922", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620922", "resource": "Reactome", "description": "BBSome-mediated cargo-targeting to cilium" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1T8S2-1", "protein_name": "Leucine zipper transcription factor-like protein 1", "gene_name": "LZTFL1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAELGLNEHHQNEVINYMRFARSKRGLRLKTVDSCFQDLKESRLVEETFTIDEVSEVLNGLQAVVHGEVESELINTAYTNVLLLRQLFSQAEKWYLKLQTDISELENRELLEQVAEFEKAEFISSNKKPIIDNIRPKLAPLNEGGAAELLNKEILRLQEENEKLKSRLKATETQATNALDEKSKLEKALQDLQLDQGNQKDFVKAQDLSDLENTVAALKSEFQKTLNDQTENQKSLEENLATAKHDLLRVQEQLSMAEKELEKKFQQTAAYRNMKEILTKKNDQIKDLRKRLAKYEPED", "length": 299 }, "evidence": [ { "id": "Q3ZBL4", "url": "https://omabrowser.org/oma/group/Q3ZBL4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7GYY4-1", "protein_name": "Leucine zipper transcription factor-like protein 1", "gene_name": "Lztfl1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNYPCLYARLCCLTTVCRQPQAELGLNEHHQNEVINYMRFARSKRGLRLKTVDACFQDLKESRLVEETFTMDEVMEVLNGLQSVVHSEVESELINTAYTNVLLLRQLFSQAEKWYLKLQTDISELENRELLEQIAEFEKAEFTSSSKKPIIDITKPKLVPINEGGTTELLNKEILRLQQENEKLKSRLKTIEIQTTNALDEKSKLERTLQDLQIDQENQQDFIKAHDLDDLENTVAALRDEFQKTLNDQTENQKSLEQNLAAAKHDLLRVQEQLSLAEKELEKKFQQTAAYRNMKEILTKKNDQIKDLRKRLAKYESED", "length": 319 }, "evidence": [ { "id": "Q3ZBL4", "url": "https://omabrowser.org/oma/group/Q3ZBL4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q562C6-1", "protein_name": "Leucine zipper transcription factor-like protein 1", "gene_name": "Lztfl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAELGLNEHHQNEVINYMRFARSKRGLRLKTVDSCFQDLKESRLVEETFTIDEVSEVLNGLQAVVHSEVESELINTAHTNVLLLRQLFSQAEKWYLKLQTDVSELENRELLEQVAEFEKAEFASSNKKPIIDITKPKLVPINEGGTTELLNKEILRLQQENEKLKSRLKTIETQAVNALDEKSKLERVLQDLQLDQGNQQDFIKAQDLDDLENTVAALKSEFQKTLNDKTENQKSLEENLAAAKHDLLRVQEQLSMAEKELEKKFQQTAAYRNMKEILTKKNDQIKDLRKRLAKYESED", "length": 299 }, "evidence": [ { "id": "Q3ZBL4", "url": "https://omabrowser.org/oma/group/Q3ZBL4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9JHQ5-1", "protein_name": "Leucine zipper transcription factor-like protein 1", "gene_name": "Lztfl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAELGLNEHHQNEVINYMRFARSKRGLRLKTVDSCFQDLKDSRLVEETFTIDEVSEVLNGLQAVVHSEVESELINTAYTNVLLLRQLFSQAEKWYLKLQTDISELENRELLEQVAEFEKAEFVSSSKKPIIDITKPKLVPINEGGTTELLNKEILRLQQENEKLKSRLKTIEIQAVNALDEKSKLERVLQDLQLDQENQQDLLKAQDLDDLENTVATLRSEFQKTLNDKTENQKSLEENLAAAKHDLLRVQEQLSMAEKELEKKFQQTAAYRNMKEILTKKNDQIKDLRKRLAKYESED", "length": 299 }, "evidence": [ { "id": "Q3ZBL4", "url": "https://omabrowser.org/oma/group/Q3ZBL4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NQ48-1", "protein_name": "Leucine zipper transcription factor-like protein 1", "gene_name": "LZTFL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAELGLNEHHQNEVINYMRFARSKRGLRLKTVDSCFQDLKESRLVEDTFTIDEVSEVLNGLQAVVHSEVESELINTAYTNVLLLRQLFAQAEKWYLKLQTDISELENRELLEQVAEFEKAEITSSNKKPILDVTKPKLAPLNEGGTAELLNKEILRLQEENEKLKSRLKTIEIQATNALDEKSKLEKALQDLQLDQGNQKDFIKAQDLSNLENTVAALKSEFQKTLNDKTENQKSLEENLATAKHDLLRVQEQLHMAEKELEKKFQQTAAYRNMKEILTKKNDQIKDLRKRLAQYEPED", "length": 299 }, "evidence": [ { "id": "Q3ZBL4", "url": "https://omabrowser.org/oma/group/Q3ZBL4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL4" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL4" } ], "pmid": "" }, { "name": "manchette", "id": "GO:0002177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002177", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL4" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL4" } ], "pmid": "" }, { "name": "negative regulation of protein localization to cilium", "id": "GO:1903565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903565", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL4" } ], "pmid": "" }, { "name": "negative regulation of protein localization to ciliary membrane", "id": "GO:1903568", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903568", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBL4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 299, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBL4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBL4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q862I1-1", "uniprot_ac": "Q862I1", "uniprot_id": "RL24_BOVIN", "mass": { "chemical_mass": 17779.0, "monoisotopic_mass": 17779.0 }, "refseq": { "ac": "NP_776880", "name": "large ribosomal subunit protein eL24", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776880" }, "gene_names": [ { "name": "RPL24", "type": "recommended", "evidence": [ { "id": "Q862I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q862I1" } ] }, { "name": "RPL24", "type": "synonym", "evidence": [ { "id": "NP_776880", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776880" } ] } ], "protein_names": [ { "name": "Large 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The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q862I1", "url": "https://www.uniprot.org/uniprotkb/Q862I1#function" }, { "database": "UniProtKB", "id": "P83731", "url": "https://www.uniprot.org/uniprotkb/P83731#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q862I1", "url": "https://www.uniprot.org/uniprotkb/Q862I1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL24", "url": "https://www.uniprot.org/uniprotkb/Q862I1", "locus": { "chromosome": "1", "start_pos": 46061447, "end_pos": 46066949, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013461", "url": "https://www.ensembl.org/id/ENSBTAG00000013461" } ] } } ], 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}, { "id": "IPR023442", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023442", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056366", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056366", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282048", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282048", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PGHGKKM", "url": "https://omabrowser.org/oma/group/PGHGKKM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q862I1", "url": "https://www.orthodb.org/?gene=Q862I1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10792", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10792", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10792:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10792:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10792:SF44", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10792:SF44", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10792:SF54", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10792:SF54", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01246", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01246", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": 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"https://www.uniprot.org/uniprotkb/A0AAA9TJY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJY5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJY5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q862I1", "url": "https://www.uniprot.org/uniprotkb/Q862I1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q862I1-1", "url": "https://www.uniprot.org/uniprotkb/Q862I1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKVELCSFSGYKIYPGHGRRYARTDGKVFQFLNAKCESAFLSKRNPRQINWTVLYRRKHKKGQSEEIQKKRTRRAVKFQRAITGASLADIMAKRNQKPEVRKAQREQAIRAAKEAKKAKQASKKTAMAAAKAPTKAAPKQKIVKPVKVSAPRVGGKR", "length": 157, "header": "sp|Q862I1-1|RL24_BOVIN Isoform 1 of Large ribosomal subunit protein eL24 OS=Bos taurus OX=9913 GN=RPL24 PE=2 SV=2 CANONICAL=Q862I1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZH1-1", "url": "https://www.uniprot.org/uniprotkb/Q862I1/entry#A0AAA9RZH1-1", "sequence": { "sequence": "MKVELCSFSGYKIYPGHGRRYARTDGKVFQFLNAKCESAFLSKRNPRQINWTVLYRRKHKKGQSEEIQKKRTRRAVKFQRAITGASLADIMAKRNQKPEVRKAQREQAIRLPQRQHLSKRL", "length": 121, "header": "tr|A0AAA9RZH1-1|RL24_BOVIN Computationally mapped isoform of Large ribosomal subunit protein eL24 OS=Bos taurus OX=9913 GN=RPL24 PE=2 SV=1 CANONICAL=Q862I1-1" }, "locus": { "chromosome": "1", "start_pos": 46066911, "end_pos": 46061535, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112430.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112430.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078989.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078989.1" } ] } }, { "isoform_ac": "A0AAA9SMB3-1", "url": "https://www.uniprot.org/uniprotkb/Q862I1/entry#A0AAA9SMB3-1", "sequence": { "sequence": "MKVELCSFSGYKIYPGHGRRYARTDGKVFQFLNAKCESAFLSKRNPRQINWTVLYRRKHKKGQSEEIQKKRTRRAVKFQRAITGASLADIMAKRNQKPEVRKAQREQAIRAAKEAKKAKQASKKTAMAAAKVIVRFLRF", "length": 139, "header": "tr|A0AAA9SMB3-1|RL24_BOVIN Computationally mapped isoform of Large ribosomal subunit protein eL24 OS=Bos taurus OX=9913 GN=RPL24 PE=2 SV=1 CANONICAL=Q862I1-1" }, "locus": { "chromosome": "1", "start_pos": 46066911, "end_pos": 46062163, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127783.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127783.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087507.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087507.1" } ] } }, { "isoform_ac": "A0AAA9TJY5-1", "url": "https://www.uniprot.org/uniprotkb/Q862I1/entry#A0AAA9TJY5-1", "sequence": { "sequence": "MKVELCSFSGYKIYPGHGRRYARTDGKVFQFLNAKCESAFLSKRNPRQINWTVLYRRKHKKGQSEEIQKKRTRRAVKFQRAITGASLADIMAKRNQKPEVRKAQREQAIRKVKVKSLSRVRLLATPWTAAYQAPPSMGFPGLPRKQKRLSKHLKRQQWLLQRLPQRQHLSKRL", "length": 173, "header": "tr|A0AAA9TJY5-1|RL24_BOVIN Computationally mapped isoform of Large ribosomal subunit protein eL24 OS=Bos taurus OX=9913 GN=RPL24 PE=2 SV=1 CANONICAL=Q862I1-1" }, "locus": { "chromosome": "1", "start_pos": 46066911, "end_pos": 46061535, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130779.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130779.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097237.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097237.1" } ] } }, { "isoform_ac": "Q862I1-1", "url": "https://www.uniprot.org/uniprotkb/Q862I1/entry#Q862I1-1", "sequence": { "sequence": "MKVELCSFSGYKIYPGHGRRYARTDGKVFQFLNAKCESAFLSKRNPRQINWTVLYRRKHKKGQSEEIQKKRTRRAVKFQRAITGASLADIMAKRNQKPEVRKAQREQAIRAAKEAKKAKQASKKTAMAAAKAPTKAAPKQKIVKPVKVSAPRVGGKR", "length": 157, "header": "sp|Q862I1-1|RL24_BOVIN Isoform 1 of Large ribosomal subunit protein eL24 OS=Bos taurus OX=9913 GN=RPL24 PE=2 SV=2 CANONICAL=Q862I1-1" }, "locus": { "chromosome": "1", "start_pos": 46066911, "end_pos": 46061491, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017905.5", "url": 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"NP_001015628", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015628" }, { "id": "Q5E966", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E966/entry#names_and_taxonomy" } ] }, { "name": "eIF3i", "type": "synonym", "evidence": [ { "id": "Q5E966", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E966/entry#names_and_taxonomy" } ] }, { "name": "eukaryotic translation initiation factor 3 subunit 2", "type": "synonym", "evidence": [ { "id": "NP_001015628", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015628" } ] }, { "name": "eukaryotic translation initiation factor 3 subunit I", "type": "synonym", "evidence": [ { "id": "NP_001015628", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015628" } ] }, { "name": "eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa", "type": "synonym", "evidence": [ { "id": "NP_001015628", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015628" } ] } ], "function": [ { "annotation": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5Y1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5Y1#function" }, { "database": "HAMAP", "id": "MF_03008", "url": "https://hamap.expasy.org/signature/MF_03008" }, { "database": "UniProtKB", "id": "A0AAA9U0C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0C5#function" }, { "database": "UniProtKB", "id": "A0AAA9TYL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYL2#function" }, { "database": "UniProtKB", "id": "Q5E966", "url": "https://www.uniprot.org/uniprotkb/Q5E966#function" }, { "database": "UniProtKB", "id": "A0AAA9TNT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNT3#function" }, { "database": "UniProtKB", "id": "ARBA00057041", "url": "https://www.uniprot.org/uniprotkb/ARBA00057041#function" }, { "database": "UniProtKB", "id": "A0AAF6ZTU5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZTU5#function" }, { "database": "UniProtKB", "id": "A0AAA9RZX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZX4#function" }, { "database": "UniProtKB", "id": "A0AAA9SK82", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK82#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E966", "url": "https://www.uniprot.org/uniprotkb/Q5E966" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF3I", "url": "https://www.uniprot.org/uniprotkb/Q5E966", "locus": { "chromosome": "2", "start_pos": 121295602, "end_pos": 121306440, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014388", "url": "https://www.ensembl.org/id/ENSBTAG00000014388" } ] } } ], "crossref": [ { "id": "Q5E966", "url": "https://alphafold.ebi.ac.uk/entry/Q5E966", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014388", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014388", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "521747", "url": "https://www.ncbi.nlm.nih.gov/gene/521747", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027525", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027525", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521747", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521747", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VWFSHNG", "url": "https://omabrowser.org/oma/group/VWFSHNG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E966", "url": "https://www.orthodb.org/?gene=Q5E966", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19877", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19877", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19877:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19877:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24805", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24805", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015628", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RZX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZX4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZX4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZX4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHA0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK82", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK82", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK82-1", "url": 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYL2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0C5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0C5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0C5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZTU5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZTU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZTU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZTU5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E966", "url": "https://www.uniprot.org/uniprotkb/Q5E966", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E966-1", "url": "https://www.uniprot.org/uniprotkb/Q5E966-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDSNEPYMRIPCNDSKITSAVWGPLGECIIAGHEGGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEA", "length": 325, "header": "sp|Q5E966-1|EIF3I_BOVIN Isoform 1 of Eukaryotic translation initiation factor 3 subunit I OS=Bos taurus OX=9913 GN=EIF3I PE=2 SV=1 CANONICAL=Q5E966-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZX4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E966/entry#A0AAA9RZX4-1", "sequence": { "sequence": "MIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDSNEPYMRIPCNDSKITSAVWGPLGECIIAGHEGGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEA", "length": 294, "header": "tr|A0AAA9RZX4-1|EIF3I_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 3 subunit I OS=Bos taurus OX=9913 GN=EIF3I PE=2 SV=1 CANONICAL=Q5E966-1" }, "locus": { "chromosome": "2", "start_pos": 121305985, "end_pos": 121298447, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100281.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100281.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075369.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075369.1" } ] } }, { "isoform_ac": "A0AAA9SHA0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E966/entry#A0AAA9SHA0-1", "sequence": { "sequence": "MKPILLQGHERSITQIKYNREGDLLFTVAKDPSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEA", "length": 181, "header": "tr|A0AAA9SHA0-1|EIF3I_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 3 subunit I OS=Bos taurus OX=9913 GN=EIF3I PE=2 SV=1 CANONICAL=Q5E966-1" }, "locus": { "chromosome": "2", "start_pos": 121305985, "end_pos": 121298447, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109964.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109964.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083289.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083289.1" } ] } }, { "isoform_ac": "A0AAA9SK82-1", "url": "https://www.uniprot.org/uniprotkb/Q5E966/entry#A0AAA9SK82-1", "sequence": { "sequence": "MGRRGAHSGEEQNYSTRIGEQTTWRRGKLILGRREMKALKKIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDSNEPYMRIPCNDSKITSAVWGPLGECIIAGHEGGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEA", "length": 334, "header": "tr|A0AAA9SK82-1|EIF3I_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 3 subunit I OS=Bos taurus OX=9913 GN=EIF3I PE=2 SV=1 CANONICAL=Q5E966-1" }, "locus": { "chromosome": "2", "start_pos": 121305505, "end_pos": 121298447, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129432.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129432.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084331.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084331.1" } ] } }, { "isoform_ac": "A0AAA9T5Y1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E966/entry#A0AAA9T5Y1-1", "sequence": { "sequence": "MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDSNEPYMRIPCNDSKITSAVWGPLGECIIAGHEGGELNQYSAKRAQPSTESAVCHRRRGLYIKLRINGASSQKRELFHRHEQSVWRHRVKGSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEA", "length": 373, "header": "tr|A0AAA9T5Y1-1|EIF3I_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 3 subunit I OS=Bos taurus OX=9913 GN=EIF3I PE=2 SV=1 CANONICAL=Q5E966-1" }, "locus": { "chromosome": "2", "start_pos": 121305985, "end_pos": 121298447, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114399.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114399.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092150.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092150.1" } ] } }, { "isoform_ac": "A0AAA9TNT3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E966/entry#A0AAA9TNT3-1", "sequence": { "sequence": "MDPGAQPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDSNEPYMRIPCNDSKITSAVWGPLGECIIAGHEGGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEA", "length": 329, "header": "tr|A0AAA9TNT3-1|EIF3I_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 3 subunit I OS=Bos taurus OX=9913 GN=EIF3I PE=2 SV=1 CANONICAL=Q5E966-1" }, "locus": { "chromosome": "2", "start_pos": 121306241, "end_pos": 121298447, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105853.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105853.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100023.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100023.1" } ] } }, { "isoform_ac": "A0AAA9TRF5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E966/entry#A0AAA9TRF5-1", "sequence": { "sequence": "MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDSNEPYMRIPCNDSKITSAVWGPLGECIIAGHEGGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYDHVLPLGL", "length": 249, "header": "tr|A0AAA9TRF5-1|EIF3I_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 3 subunit I OS=Bos taurus OX=9913 GN=EIF3I PE=2 SV=1 CANONICAL=Q5E966-1" }, "locus": { "chromosome": "2", "start_pos": 121305985, "end_pos": 121298728, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095789.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095789.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099898.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099898.1" } ] } }, { "isoform_ac": "A0AAA9TYL2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E966/entry#A0AAA9TYL2-1", "sequence": { "sequence": "MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETDSNEPYMRIPCNDSKITSAVWGPLGECIIAGHEGGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEA", "length": 275, "header": "tr|A0AAA9TYL2-1|EIF3I_BOVIN Computationally mapped 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mapped isoform of Eukaryotic translation initiation factor 3 subunit I OS=Bos taurus OX=9913 GN=EIF3I PE=2 SV=1 CANONICAL=Q5E966-1" }, "locus": { "chromosome": "2", "start_pos": 121305985, "end_pos": 121295602, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077067.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077067.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057668.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057668.2" } ] } }, { "isoform_ac": "Q5E966-1", "url": "https://www.uniprot.org/uniprotkb/Q5E966/entry#Q5E966-1", "sequence": { "sequence": "MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDSNEPYMRIPCNDSKITSAVWGPLGECIIAGHEGGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEA", "length": 325, "header": "sp|Q5E966-1|EIF3I_BOVIN Isoform 1 of Eukaryotic translation initiation factor 3 subunit I OS=Bos taurus OX=9913 GN=EIF3I PE=2 SV=1 CANONICAL=Q5E966-1" }, "locus": { "chromosome": "2", "start_pos": 121306107, "end_pos": 121298447, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019134.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019134.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019134.3", "url": "https://www.ensembl.org/id/ENSBTAP00000019134.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 219, "end_pos": 219, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E966", "url": "https://www.uniprot.org/uniprotkb/Q5E966" } ], "site_lbl": "Thr219" }, { "start_pos": 308, "end_pos": 308, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q5E966", "url": "https://www.uniprot.org/uniprotkb/Q5E966" } ], "site_lbl": "Tyr308" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E966", "url": "https://www.uniprot.org/uniprotkb/Q5E966" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:521747", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521747", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-72649", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "resource": "Reactome", "description": "Translation initiation complex formation" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "resource": "Reactome", "description": "Formation of the ternary complex, and subsequently, the 43S complex" }, { "id": "R-BTA-72702", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "resource": "Reactome", "description": "Ribosomal scanning and start codon recognition" } ], "orthologs": [ { "uniprot_canonical_ac": "B0BNA7-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit I", "gene_name": "Eif3i", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDSNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTSLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEA", "length": 325 }, "evidence": [ { "id": "Q5E966", "url": "https://omabrowser.org/oma/group/Q5E966/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1C6T8-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit I", "gene_name": "EIF3I", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYNGHTGAVWCVDADWDTRHVLTGSADNSCRLWDCETGKQLALVKTSSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIENNEPYMKIPCSDSKITSAVWGPLGEFIIAGHESGELNQFSAKSGEQLSNIKEHTKQINDIQTSRDMTMFITASKDNTAKLFDCTTLEHLKTFRTERPVNSAALSPIFDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEA", "length": 325 }, "evidence": [ { "id": "Q5E966", "url": "https://omabrowser.org/oma/group/Q5E966/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3H945-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit I", "gene_name": "Eif3i", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKPILLQGHERSITQIKYNREGDLLFTVAKDPTVNVWYSVNGERLGTYIGHGGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMLSTDKQMGYQCSVSFFDLRDPSQIDTNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVSVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTSLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEA", "length": 325 }, "evidence": [ { "id": "Q5E966", "url": "https://omabrowser.org/oma/group/Q5E966/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O02195-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit I", "gene_name": "eIF3i", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": 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"MKAIKLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFTKYCVTGSADYSIKLWDVSNGQCVATWKSPVPVKRVEFSPCGNYFLAILDNVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKYETDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIRLHHFEKSYFDFKYDVEKAAEAKEHMQEAN", "length": 347 }, "evidence": [ { "id": "Q5E966", "url": "https://omabrowser.org/oma/group/Q5E966/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q13347-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit I", "gene_name": "EIF3I", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"UniProtKB", "id": "Q5E966", "url": "https://www.uniprot.org/uniprotkb/Q5E966" } ], "pmid": "" }, { "name": "formation of cytoplasmic translation initiation complex", "id": "GO:0001732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001732", "evidence": [ { "database": "UniProtKB", "id": "Q5E966", "url": "https://www.uniprot.org/uniprotkb/Q5E966" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q5E966", "url": "https://www.uniprot.org/uniprotkb/Q5E966" } ], "pmid": "" }, { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "Q5E966", "url": "https://www.uniprot.org/uniprotkb/Q5E966" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "eukaryotic 43S 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"MAFKDTGKTPVEPEVAIHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVKGPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVEVEVTIADA", "length": 119 }, "evidence": [ { "id": "Q3ZBH8", "url": "https://omabrowser.org/oma/group/Q3ZBH8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P60867-1", "protein_name": "Small ribosomal subunit protein uS10", "gene_name": "Rps20", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFKDTGKTPVEPEVAIHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVKGPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVEVEVTIADA", "length": 119 }, "evidence": [ { "id": "Q3ZBH8", "url": "https://omabrowser.org/oma/group/Q3ZBH8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P60868-1", "protein_name": "Small ribosomal subunit protein uS10", "gene_name": "Rps20", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAFKDTGKTPVEPEVAIHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVKGPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVEVEVTIADA", "length": 119 }, "evidence": [ { "id": "Q3ZBH8", "url": "https://omabrowser.org/oma/group/Q3ZBH8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBH8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH8" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBH8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBH8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosolic small ribosomal subunit", "id": "GO:0022627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022627", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBH8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH8" } ], "pmid": "" }, { "name": "cytosolic ribosome", "id": "GO:0022626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022626", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBH8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH8" } ], "pmid": "" }, { "name": "small ribosomal subunit", "id": "GO:0015935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015935", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBH8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBH8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 119, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBH8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBH8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 9, 93 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { 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"table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q866T7-1", "uniprot_ac": "Q866T7", "uniprot_id": "CXD2_BOVIN", "mass": { "chemical_mass": 36126.0, "monoisotopic_mass": 36126.0 }, "refseq": { "ac": "NP_777108", "name": "gap junction delta-2 protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777108" }, "gene_names": [ { "name": "GJD2", "type": "recommended", "evidence": [ { "id": "Q866T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q866T7" } ] }, { "name": "CXNS", "type": "synonym", "evidence": [ { "id": "NP_777108", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777108" } ] }, { "name": "Cx36", "type": "synonym", "evidence": [ { "id": "NP_777108", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777108" } ] }, { "name": "GJA9", "type": "synonym", "evidence": [ { "id": "Q866T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q866T7" } ] }, { "name": "GJD2", "type": "synonym", "evidence": [ { "id": "NP_777108", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777108" } ] } ], "protein_names": [ { "name": "Gap junction delta-2 protein", "type": "recommended", "evidence": [ { "id": "Q866T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q866T7/entry#names_and_taxonomy" } ] }, { "name": "Connexin-36", "type": "synonym", "evidence": [ { "id": "Q866T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q866T7/entry#names_and_taxonomy" } ] }, { "name": "Cx36", "type": "synonym", "evidence": [ { "id": "Q866T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q866T7/entry#names_and_taxonomy" } ] }, { "name": "Gap junction alpha-9 protein", "type": "synonym", "evidence": [ { "id": "Q866T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q866T7/entry#names_and_taxonomy" } ] }, { "name": "connexin S", "type": "synonym", "evidence": [ { "id": "NP_777108", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777108" } ] }, { "name": "connexin-36", "type": "synonym", "evidence": [ { "id": "NP_777108", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777108" } ] }, { "name": "gap junction alpha-9 protein", "type": "synonym", "evidence": [ { "id": "NP_777108", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777108" } ] }, { "name": "gap junction delta-2 protein", "type": "synonym", "evidence": [ { "id": "NP_777108", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777108" } ] }, { "name": "gap junction membrane channel protein alpha 9", "type": "synonym", "evidence": [ { "id": "NP_777108", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777108" } ] }, { "name": "gap junction protein, alpha 9, 36kDa", "type": "synonym", "evidence": [ { "id": "NP_777108", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777108" } ] }, { "name": "gap junction protein, alpha 9, 59kDa", "type": "synonym", "evidence": [ { "id": "NP_777108", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777108" } ] }, { "name": "gap junction protein, delta 2, 36kDa", "type": "synonym", "evidence": [ { "id": "NP_777108", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777108" } ] } ], "function": [ { "annotation": "Interneuronal communication at gap junctions made by connexin 36 may not be regulated by direct phosphorylation of connexin 36, but possibly by phosphorylation of associated proteins.", "evidence": [ { "database": "RefSeq", "id": "NP_777108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777108" }, { "database": "PubMed", "id": "14658767", "url": "https://glygen.org/publication/PubMed/14658767" } ] }, { "annotation": "One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.", "evidence": [ { "database": "UniProtKB", "id": "Q866T7", "url": "https://www.uniprot.org/uniprotkb/Q866T7#function" }, { "database": "UniProtKB", "id": "A0AAA9S127", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S127#function" }, { "database": "UniProtKB", "id": "ARBA00003922", "url": "https://www.uniprot.org/uniprotkb/ARBA00003922#function" } ] }, { "annotation": "Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage. Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S127", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S127#function" }, { "database": "UniProtKB", "id": "RU000630", "url": "https://www.uniprot.org/uniprotkb/RU000630#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q866T7", "url": "https://www.uniprot.org/uniprotkb/Q866T7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GJD2", "url": "https://www.uniprot.org/uniprotkb/Q866T7", "locus": { "chromosome": "10", "start_pos": 30231349, "end_pos": 30257852, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021730", "url": "https://www.ensembl.org/id/ENSBTAG00000021730" } ] } } ], "crossref": [ { "id": "Q866T7", "url": "https://alphafold.ebi.ac.uk/entry/Q866T7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021730", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021730", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "282577", "url": "https://www.ncbi.nlm.nih.gov/gene/282577", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002260", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002260", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013092", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013092", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019570", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019570", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282577", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282577", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KEMEPDC", "url": "https://omabrowser.org/oma/group/KEMEPDC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q866T7", "url": "https://www.orthodb.org/?gene=Q866T7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11984", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11984:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00029", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00029", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-112303", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112303", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-190861", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-190861", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_777108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777108", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S127", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S127", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S127-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S127-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q866T7", "url": "https://www.uniprot.org/uniprotkb/Q866T7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q866T7-1", "url": "https://www.uniprot.org/uniprotkb/Q866T7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQPGCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDPPESMGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSGLRTASRSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECDRYPCIKEVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSVYEIRNKDLPRVSVPNFGRTQSSDSAYV", "length": 321, "header": "sp|Q866T7-1|CXD2_BOVIN Isoform 1 of Gap junction delta-2 protein OS=Bos taurus OX=9913 GN=GJD2 PE=2 SV=1 CANONICAL=Q866T7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S127-1", "url": "https://www.uniprot.org/uniprotkb/Q866T7/entry#A0AAA9S127-1", "sequence": { "sequence": "MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQPGCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDPPESMGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSGLRTASRSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECDRYPCIKEVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSVYEIRNKDLPRVYSSTWAAVTKYHEWSGLNKRNLSSHHSAICKSKIKFSTEDHHTTILWTPLQGLKP", "length": 360, "header": "tr|A0AAA9S127-1|CXD2_BOVIN Computationally mapped isoform of Gap junction delta-2 protein OS=Bos taurus OX=9913 GN=GJD2 PE=2 SV=1 CANONICAL=Q866T7-1" }, "locus": { "chromosome": "10", "start_pos": 30257275, "end_pos": 30231504, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133535.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133535.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077363.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077363.1" } ] } }, { "isoform_ac": "Q866T7-1", "url": "https://www.uniprot.org/uniprotkb/Q866T7/entry#Q866T7-1", "sequence": { "sequence": "MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQPGCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDPPESMGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSGLRTASRSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECDRYPCIKEVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSVYEIRNKDLPRVSVPNFGRTQSSDSAYV", "length": 321, "header": "sp|Q866T7-1|CXD2_BOVIN Isoform 1 of Gap junction delta-2 protein OS=Bos taurus OX=9913 GN=GJD2 PE=2 SV=1 CANONICAL=Q866T7-1" }, "locus": { "chromosome": "10", "start_pos": 30257275, "end_pos": 30255326, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028966.4", "url": "https://www.ensembl.org/id/ENSBTAT00000028966.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028966.2", "url": "https://www.ensembl.org/id/ENSBTAP00000028966.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Connexin 36 in bovine retina: lack of phosphorylation but evidence for association with phosphorylated proteins.", "journal": "Visual neuroscience", "date": "2003", "authors": "Sitaramayya Ari, Crabb John W, Matesic Diane F, Margulis Alexander, Singh Vinita, Pulukuri Sadhona, Dang Loan", "evidence": [ { "database": "RefSeq", "id": "NP_777108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777108" } ], "reference": [ { "type": "PubMed", "id": "14658767", "url": "https://glygen.org/publication/PubMed/14658767" } ] } ], "pathway": [ { "id": "bta:282577", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282577", "resource": "KEGG Pathway" }, { "id": "R-BTA-112303", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112303", "resource": "Reactome", "description": "Electric Transmission Across Gap Junctions" }, { "id": "R-BTA-190861", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-190861", "resource": "Reactome", "description": "Gap junction assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AL56-1", "protein_name": "Gap junction protein", "gene_name": "GJD2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQPGCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDPPESMGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSGLRTAARSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECDRYPCIKEVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSVYEIRNKDLPRVSVPNFGRTQSSDSAYV", "length": 321 }, "evidence": [ { "id": "Q866T7", "url": "https://omabrowser.org/oma/group/Q866T7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H5Q1-1", "protein_name": "Gap junction protein", "gene_name": "Gjd2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQPGCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDPTESIGGPGGTGVGGSGGSKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSGLRTAARSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSVYEIRNKDLPRVSVPNFGRTQSSDSAYV", "length": 321 }, "evidence": [ { "id": "Q866T7", "url": "https://omabrowser.org/oma/group/Q866T7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O54851-1", "protein_name": "Gap junction delta-2 protein", "gene_name": "Gjd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQPGCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDPAESIGGPGGTGGGGSGGSKREDKKLQNAIVNGVLQNTETTSKETEPDCLEVKELTPHPSGLRTAARSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSVYEIRNKDLPRVSVPNFGRTQSSDSAYV", "length": 321 }, "evidence": [ { "id": "Q866T7", "url": "https://omabrowser.org/oma/group/Q866T7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O70610-1", "protein_name": "Gap junction delta-2 protein", "gene_name": "Gjd2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQPGCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDPAESIGGPGGTGGGGSGGSKREDKKLQNAIVNGVLQNTETTSKETEPDCLEVKELAPHPSGLRTAARSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSVYEIRNKDLPRVSVPNFGRTQSSDSAYV", "length": 321 }, "evidence": [ { "id": "Q866T7", "url": "https://omabrowser.org/oma/group/Q866T7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8JFD6-1", "protein_name": "Gap junction protein", "gene_name": "gjd2b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQSMFVCNTLQPGCNQACYDKAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQKERRYSTIYLSLDKDPDTMRRDDSKKIKNTIVNGVLQNTENSTKESEPDCLEVKEIPNSAMRTTKSKMRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFNVPAVYECDRYPCIKDVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKTAVRGVQARRKSIYEIRNKDLPRMSMPNFGRTQSSDSAYV", "length": 304 }, "evidence": [ { "id": "Q866T7", "url": "https://omabrowser.org/oma/group/Q866T7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9UKL4-1", "protein_name": "Gap junction delta-2 protein", "gene_name": "GJD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQPGCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDPPESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSGLRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRGAQAKRKSIYEIRNKDLPRVSVPNFGRTQSSDSAYV", "length": 321 }, "evidence": [ { "id": "Q866T7", "url": "https://omabrowser.org/oma/group/Q866T7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell-cell signaling", "id": "GO:0007267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007267", "evidence": [ { "database": "UniProtKB", "id": "Q866T7", "url": "https://www.uniprot.org/uniprotkb/Q866T7" } ], "pmid": "" }, { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "Q866T7", "url": "https://www.uniprot.org/uniprotkb/Q866T7" } ], "pmid": "" }, { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "Q866T7", "url": "https://www.uniprot.org/uniprotkb/Q866T7" } ], "pmid": "" }, { "name": "cell communication", "id": "GO:0007154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007154", "evidence": [ { "database": "UniProtKB", "id": "Q866T7", "url": "https://www.uniprot.org/uniprotkb/Q866T7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "Q866T7", "url": "https://www.uniprot.org/uniprotkb/Q866T7" } ], "pmid": "" }, { "name": "connexin complex", "id": "GO:0005922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005922", "evidence": [ { "database": "UniProtKB", "id": "Q866T7", "url": "https://www.uniprot.org/uniprotkb/Q866T7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "gap junction channel activity", "id": "GO:0005243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005243", "evidence": [ { "database": "UniProtKB", "id": "Q866T7", "url": "https://www.uniprot.org/uniprotkb/Q866T7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q866T7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 321, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q866T7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q866T7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 159, "end_pos": 161 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9T6-1", "uniprot_ac": "Q5E9T6", "uniprot_id": "LGI1_BOVIN", "mass": { "chemical_mass": 61161.0, "monoisotopic_mass": 61161.0 }, "refseq": { "ac": "NP_001040056", "name": "leucine-rich glioma-inactivated protein 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040056" }, "gene_names": [ { "name": "LGI1", "type": "recommended", "evidence": [ { "id": "Q5E9T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6" } ] }, { "name": "LGI1", "type": "synonym", "evidence": [ { "id": "NP_001040056", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040056" } ] } ], "protein_names": [ { "name": "Leucine-rich glioma-inactivated protein 1", "type": "recommended", "evidence": [ { "id": "Q5E9T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich glioma-inactivated protein 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001040056", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040056" } ] }, { "name": "leucine-rich glioma-inactivated protein 1", "type": "synonym", "evidence": [ { "id": "NP_001040056", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040056" } ] } ], "function": [ { "annotation": "Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T6", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6#function" }, { "database": "UniProtKB", "id": "O95970", "url": "https://www.uniprot.org/uniprotkb/O95970#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9T6", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LGI1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6", "locus": { "chromosome": "26", "start_pos": 15284717, "end_pos": 15237569, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005106", "url": "https://www.ensembl.org/id/ENSBTAG00000005106" } ] } } ], "crossref": [ { "id": "Q5E9T6", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9T6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005106", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005106", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617080", "url": "https://www.ncbi.nlm.nih.gov/gene/617080", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005492", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005492", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051295", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051295", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617080", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617080", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VEMNFRN", "url": "https://omabrowser.org/oma/group/VEMNFRN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9T6", "url": "https://www.orthodb.org/?gene=Q5E9T6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24367", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24367", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24367:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24367:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03736", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03736", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5682910", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5682910", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001040056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040056", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S158", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S158", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S158-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S158-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBB6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBB6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9T6", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9T6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESERSQRMGNACIPLKRIAYCLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARSIPRTVPPDVISLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLSHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYMNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIARTPQTLRTPHLILSSSSQRPVIYQWNKAIQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA", "length": 533, "header": "sp|Q5E9T6-1|LGI1_BOVIN Isoform 1 of Leucine-rich glioma-inactivated protein 1 OS=Bos taurus OX=9913 GN=LGI1 PE=2 SV=1 CANONICAL=Q5E9T6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S158-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6/entry#A0AAA9S158-1", "sequence": { "sequence": "MESERSQRMGNACIPLKRIAYCLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLSHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYMNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIARTPQTLRTPHLILSSSSQRPVIYQWNKAIQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA", "length": 509, "header": "tr|A0AAA9S158-1|LGI1_BOVIN Computationally mapped isoform of Leucine-rich glioma-inactivated protein 1 OS=Bos taurus OX=9913 GN=LGI1 PE=2 SV=1 CANONICAL=Q5E9T6-1" }, "locus": { "chromosome": "26", "start_pos": 15277537, "end_pos": 15237860, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088613.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088613.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077051.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077051.1" } ] } }, { "isoform_ac": "A0AAA9SBB6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6/entry#A0AAA9SBB6-1", "sequence": { "sequence": "MESERSQRMGNACIPLKRIAYCLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLSHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYMNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIARTPQTLRTPHLILSSSSQRPVIYQWNKAIQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA", "length": 557, "header": "tr|A0AAA9SBB6-1|LGI1_BOVIN Computationally mapped isoform of Leucine-rich glioma-inactivated protein 1 OS=Bos taurus OX=9913 GN=LGI1 PE=2 SV=1 CANONICAL=Q5E9T6-1" }, "locus": { "chromosome": "26", "start_pos": 15277537, "end_pos": 15237860, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091034.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091034.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083385.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083385.1" } ] } }, { "isoform_ac": "A0AAA9SJN3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6/entry#A0AAA9SJN3-1", "sequence": { "sequence": "MESERSQRMGNACIPLKRIAYCLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLSHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYMNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGLSWWCPCQ", "length": 288, "header": "tr|A0AAA9SJN3-1|LGI1_BOVIN Computationally mapped isoform of Leucine-rich glioma-inactivated protein 1 OS=Bos taurus OX=9913 GN=LGI1 PE=2 SV=1 CANONICAL=Q5E9T6-1" }, "locus": { "chromosome": "26", "start_pos": 15284717, "end_pos": 15237860, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107301.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107301.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084107.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084107.1" } ] } }, { "isoform_ac": "Q5E9T6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6/entry#Q5E9T6-1", "sequence": { "sequence": "MESERSQRMGNACIPLKRIAYCLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARSIPRTVPPDVISLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLSHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYMNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIARTPQTLRTPHLILSSSSQRPVIYQWNKAIQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA", "length": 533, "header": "sp|Q5E9T6-1|LGI1_BOVIN Isoform 1 of Leucine-rich glioma-inactivated protein 1 OS=Bos taurus OX=9913 GN=LGI1 PE=2 SV=1 CANONICAL=Q5E9T6-1" }, "locus": { "chromosome": "26", "start_pos": 15277537, "end_pos": 15237860, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006728.5", "url": "https://www.ensembl.org/id/ENSBTAT00000006728.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006728.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006728.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 168, "start_aa": "Asn", "end_pos": 168, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn168", "evidence": [ { "id": "Q5E9T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 253, "start_aa": "Asn", "end_pos": 253, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn253", "evidence": [ { "id": "Q5E9T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 398, "start_aa": "Asn", "end_pos": 398, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn398", "evidence": [ { "id": "Q5E9T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T6", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:617080", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617080", "resource": "KEGG Pathway" }, { "id": "R-BTA-5682910", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5682910", "resource": "Reactome", "description": "LGI-ADAM interactions" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PFF3-1", "protein_name": "Leucine-rich glioma-inactivated protein 1", "gene_name": "LGI1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGNASRPFRRIAYFLCLLSVLLLTEGKKPVKPKCPAWCTCTKDNALCENARSIPRSVPPDVISLSFVRSAFTKIPEGSFLLTPSLQLLLFTSNTFDVISDDAFMGLPHLEYLFIENNSIKSISRNTFRGLKSLIHLSLANNNLQSLPKDIFKGLDSLTNVDLRGNAFNCDCKLKWLVEWLGSTNATVEDIYCESPPEYKKRKINSLSSKEFDCIITEFEVFQSLPYQSLSVDTFSYMNDEHVVIAQPFTGKCIFLEWDHVEVMFRNYDNITGTSTVVCKPIVIESQLYVIVAQLFGGSHIYKRDIFANKFIKIQDIEILKIRKPNDIETFRIAEDWYFVVADSSKAGFTTVYKWNGNGFYSHQSLHAWYRDTDVEFLEIAGKPHLILSSSSQRPVIYQWNKGTNEFVKRFDIQDMEDAYAVKHFKVKEDVYICLTRFIGDSKVMKWGGSAFLDLQRMPSRGSMVFQPLQIRNYQYAILGSDYSFTQVYYWDAEKAKFVKFQELNIQAPRSFIHVSIDKRDFLFASSFKGTTLIYKHVRVDLSA", "length": 543 }, "evidence": [ { "id": "Q5E9T6", "url": "https://omabrowser.org/oma/group/Q5E9T6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8C2LGF5-1", "protein_name": "Leucine-rich glioma-inactivated protein 1", "gene_name": "Lgi1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MESERSRRMGNACIPLKRIAYFLCLFSVVLLTEGKKPAKPKCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSPKDFDCIITEFAKSQDLPYQSLSIDTFSYMNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIDTQLYVIVAQLFGGSHIYKRDGFANKFIKIQDIEVLKIRKPNDIETFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIARTPLTLRTPHLILSSSSQRPVIYQWSKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA", "length": 557 }, "evidence": [ { "id": "Q5E9T6", "url": "https://omabrowser.org/oma/group/Q5E9T6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8D0X5U1-1", "protein_name": "Leucine-rich glioma-inactivated protein 1", "gene_name": "LGI1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQVRSLLQQLDPSHLAAPHRSLPRAVHRWSKEQLTNQLQVPVLKSREAEAKEKGGLLCDLVLEQDNHHLNSRNPVHVWGYFFDCMESERSQRMGNACIPLKRIAYCLCLLSALWLTEGKKPAKPKCPAVCTCTKDNALCENARSIPRNVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSTKDFDCIITEFAKSQDLPYQSLSIDTFSYMNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIARTPQTLRTPHLILSSSSQRPVIYQWNKAIQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA", "length": 641 }, "evidence": [ { "id": "Q5E9T6", "url": "https://omabrowser.org/oma/group/Q5E9T6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O95970-1", "protein_name": "Leucine-rich glioma-inactivated protein 1", "gene_name": "LGI1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA", "length": 557 }, "evidence": [ { "id": "Q5E9T6", "url": "https://omabrowser.org/oma/group/Q5E9T6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8K4Y5-1", "protein_name": "Leucine-rich glioma-inactivated protein 1", "gene_name": "Lgi1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MESESIRRMGNACIPLKRIAYFLCLFSVVLLTEGKKPAKPKCPAVCTCSKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSPKDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIDTQLYVIVAQLFGGSHIYKRDGFANKFIKIQDIEVLKIRKPNDIETFKIEDNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIARPPLTLRTPHLILSSSSQRPVIYQWSKATQLFINQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA", "length": 557 }, "evidence": [ { "id": "Q5E9T6", "url": "https://omabrowser.org/oma/group/Q5E9T6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9JIA1-1", "protein_name": "Leucine-rich glioma-inactivated protein 1", "gene_name": "Lgi1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESESSRRMGNACIPLKRIAYFLCLFSVVLLTEGKKPAKPKCPAVCTCSKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNAFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSPKDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIDTQLYVIVAQLFGGSHIYKRDGFANKFIKIQDIEVLKIRKPNDIETFKIEDNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIARPPLALRTPHLILSSSSQRPVIYQWSKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA", "length": 557 }, "evidence": [ { "id": "Q5E9T6", "url": "https://omabrowser.org/oma/group/Q5E9T6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T6", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T6", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T6", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T6", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6" } ], "pmid": "" }, { "name": "synaptic cleft", "id": "GO:0043083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043083", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T6", "url": "https://www.uniprot.org/uniprotkb/Q5E9T6" } ], "pmid": "" }, { "name": 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Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. 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"MASGDRRQPQAATKPAFGEEEAAELVDKVFGLKAVWVRPLPSYDDQNFHVKVSDGGEAEGAEEYVLKITNSEDSQQPALIEAQTRAMVFLSAHGFPSATPRLTKDGGIMSVQEGGSRPGNQKYVVRLLTYLPGTPVAKIAAPTQLLYDIGKLAASLDKALTEQFHHPSVSSLHRGQFIWNLANVPLLEQYVDALGQNEYREVVEWVIQQFKEKVTPKISSFRPCINHGDLNDHNILVVPGSPRGAAPQYRVSGVLDFSDMSYGRYVFEAAIAIMYMMVESAEPLRVGGHVLAGFESVVPLTGGERAALFLLARCPAAPAPCLEDMTPEPPYFLQKAACTRLSMPWRQSDTRVLAWASWPTMVFCWLQRGATFISSSMRFSSQKRSTN", "length": 387 }, "evidence": [ { "id": "Q3ZCK9", "url": "https://omabrowser.org/oma/group/Q3ZCK9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3H0C2-1", "protein_name": "Proteasome subunit alpha type", "gene_name": "Psma4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTMIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQKEKDK", "length": 261 }, "evidence": [ { "id": "Q3ZCK9", "url": "https://omabrowser.org/oma/group/Q3ZCK9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O81148-1", "protein_name": "Proteasome subunit alpha type-4-A", "gene_name": "PAC1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSRRYDSRTTIFSPEGRLYQVEYAMEAIGNAGSAIGILSKDGVVLIGEKKVTSKLLQTSTSAEKMYKIDDHVACAVAGIMSDANILINTARVQAQRYTFMYQEPMPVEQLVQSLCDTKQGYTQFGGLRPFGVSFLFAGWDKHHGFQLYMSDPSGNYGGWKAAAVGANNQAAQSILKQDYKDDATREEAVELALKVLTKTMDSTSLTSEKLELAEVYLTPSKTVKYHVHSPESLTKLLVKHGVTQPAAETS", "length": 250 }, "evidence": [ { "id": "Q3ZCK9", "url": "https://omabrowser.org/oma/group/Q3ZCK9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P18053-1", "protein_name": "Proteasome subunit alpha type-4", "gene_name": "Prosalpha3", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MARRYDSRTTIFSPEGRLYQVEYAMEAISHAGTCLGILAEDGILLAAECRSTNKLLDSAIPSEKIYRLNDNMVCSVAGITSDANVLTSELRLIAQRYQFSYGEVIPCEQLVSHLCDIKQAYTQYGGKRPFGVSLLYMGWDNKYGYQLYQSDPSGNYGGWKATCIGNNFGAAISMLKQELADKENVKLTLADAKDLAIKVLSMTLDTTKLTPEKVEMATLQRVDNKTVYSVLEKPDVEKLIEKYTKVQAEAEAAKKEKQAKQPTK", "length": 264 }, "evidence": [ { "id": "Q3ZCK9", "url": "https://omabrowser.org/oma/group/Q3ZCK9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P21670-1", "protein_name": "Proteasome subunit alpha type-4", "gene_name": "Psma4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAVKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQREKDK", "length": 261 }, "evidence": [ { "id": "Q3ZCK9", "url": "https://omabrowser.org/oma/group/Q3ZCK9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P23638-1", "protein_name": "Proteasome subunit alpha type-3", "gene_name": "PRE9", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MGSRRYDSRTTIFSPEGRLYQVEYALESISHAGTAIGIMASDGIVLAAERKVTSTLLEQDTSTEKLYKLNDKIAVAVAGLTADAEILINTARIHAQNYLKTYNEDIPVEILVRRLSDIKQGYTQHGGLRPFGVSFIYAGYDDRYGYQLYTSNPSGNYTGWKAISVGANTSAAQTLLQMDYKDDMKVDDAIELALKTLSKTTDSSALTYDRLEFATIRKGANDGEVYQKIFKPQEIKDILVKTGITKKDEDEEADEDMK", "length": 258 }, "evidence": [ { "id": "Q3ZCK9", "url": "https://omabrowser.org/oma/group/Q3ZCK9/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P25789-1", "protein_name": "Proteasome subunit alpha type-4", "gene_name": "PSMA4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQKEKDK", "length": 261 }, "evidence": [ { "id": "Q3ZCK9", "url": "https://omabrowser.org/oma/group/Q3ZCK9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P34119-1", "protein_name": "Proteasome subunit alpha type-4", "gene_name": "psmA4", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MARRYDQRTTIFSPEGRVYQVEYAMTAIRHAGATVGILAKDGIVLAAEKKTTAKLLDSSTSISEKMFKIDEHVVCAVAGITSDANILINYARLSSQRFFYQYQEPMPVEQLVSQICDTKQGYTQYGGLRPFGVSFLYAGWDRHYGFQLYQSDPSGNFAGWKATSIGGENSQVAQSVLRSNYKPDISLKEALQLALKVLTKTMDRSNINSEKLEFSYFTKQGDNVVYHIFTAAELDAFIKETDLEQETEDN", "length": 250 }, "evidence": [ { "id": "Q3ZCK9", "url": "https://omabrowser.org/oma/group/Q3ZCK9/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9R1P0-1", "protein_name": "Proteasome subunit alpha type-4", "gene_name": "Psma4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAVKVLNKTMDVSKLSAEKVEIATLTRESGKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQREKDK", "length": 261 }, "evidence": [ { "id": "Q3ZCK9", "url": "https://omabrowser.org/oma/group/Q3ZCK9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK9" } ], "pmid": "" }, { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK9" } ], "pmid": "" }, { "name": "proteasome core complex, alpha-subunit complex", "id": "GO:0019773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019773", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK9" } ], "pmid": "" }, { "name": "proteasome core complex", "id": "GO:0005839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005839", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK9" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK9" } ], "pmid": "" }, { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK9" } ], "pmid": "" }, { "name": "regulation of proteasomal protein catabolic process", "id": "GO:0061136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061136", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCK9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 261, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCK9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCK9" }, { "pdb_id": "1iru", "pdb_chain": "c/q", "start_pos": 1, "end_pos": 261, "overlap": "1.0", "method": "X-Ray_Crystallography", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/1iru.pdb", "url_external": "https://www.rcsb.org/structure/1iru" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 13, 75, 173 ], "sequon_annotation_sites": [ { "start_pos": 166, "end_pos": 168 }, { "start_pos": 198, "end_pos": 200 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { 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"kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q4U0T9-1", "uniprot_ac": "Q4U0T9", "uniprot_id": "CSRP3_BOVIN", "mass": { "chemical_mass": 20953.0, "monoisotopic_mass": 20953.0 }, "refseq": { "ac": "NP_001019860", "name": "cysteine and glycine-rich protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019860" }, "gene_names": [ { "name": "CSRP3", "type": "recommended", "evidence": [ { "id": "Q4U0T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U0T9" } ] }, { "name": "CRP3", "type": "synonym", "evidence": [ { "id": "NP_001019860", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019860" } ] }, { "name": "CSRP3", "type": "synonym", "evidence": [ { "id": "NP_001019860", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019860" } ] } ], "protein_names": [ { "name": "Cysteine and glycine-rich protein 3", "type": "recommended", "evidence": [ { "id": "Q4U0T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U0T9/entry#names_and_taxonomy" } ] }, { "name": "CRP3", "type": "synonym", "evidence": [ { "id": "Q4U0T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U0T9/entry#names_and_taxonomy" } ] }, { "name": "Cysteine-rich protein 3", "type": "synonym", "evidence": [ { "id": "Q4U0T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U0T9/entry#names_and_taxonomy" } ] }, { "name": "cysteine and glycine-rich protein 3 (cardiac LIM protein)", "type": "synonym", "evidence": [ { "id": "NP_001019860", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019860" } ] }, { "name": "cysteine and glycine-rich protein 3", "type": "synonym", "evidence": [ { "id": "NP_001019860", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019860" } ] }, { "name": "cysteine-rich protein 3", "type": "synonym", "evidence": [ { "id": "NP_001019860", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019860" } ] } ], "function": [ { "annotation": "Data support the high potential of the CSRP3 as a marker gene for the improvement of growth performance and carcass traits in selection programs", "evidence": [ { "database": "RefSeq", "id": "NP_001019860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019860" }, { "database": "PubMed", "id": "24279998", "url": "https://glygen.org/publication/PubMed/24279998" } ] }, { "annotation": "Positive regulator of myogenesis. Acts as a cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation. The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly. Proposed to contribute to the maintenance of muscle cell integrity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association. In vitro can inhibit PKC/PRKCA activity. Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q4U0T9", "url": "https://www.uniprot.org/uniprotkb/Q4U0T9#function" }, { "database": "UniProtKB", "id": "P50462", "url": "https://www.uniprot.org/uniprotkb/P50462#function" }, { "database": "UniProtKB", "id": "P50461", "url": "https://www.uniprot.org/uniprotkb/P50461#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q4U0T9", "url": "https://www.uniprot.org/uniprotkb/Q4U0T9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CSRP3", "url": "https://www.uniprot.org/uniprotkb/Q4U0T9", "locus": { "chromosome": "29", "start_pos": 25764911, "end_pos": 25744235, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011869", "url": "https://www.ensembl.org/id/ENSBTAG00000011869" } ] } } ], "crossref": [ { "id": "Q4U0T9", "url": "https://alphafold.ebi.ac.uk/entry/Q4U0T9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011869", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011869", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09481", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09481", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09482", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09482", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540407", "url": "https://www.ncbi.nlm.nih.gov/gene/540407", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540407", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540407", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TCYGRRY", "url": "https://omabrowser.org/oma/group/TCYGRRY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q4U0T9", "url": "https://www.orthodb.org/?gene=Q4U0T9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24215", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24215", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24215:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24215:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001019860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019860", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S499", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S499", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S499-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S499-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q4U0T9", "url": "https://www.uniprot.org/uniprotkb/Q4U0T9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q4U0T9-1", "url": "https://www.uniprot.org/uniprotkb/Q4U0T9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPNWGGGAKCGACEKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRRYGPKGIGYGQGAGCLSTDTGEHLGLQFQQSPKQARSATTSSNPSKFAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTGIGFGGLTHQVEKKD", "length": 194, "header": "sp|Q4U0T9-1|CSRP3_BOVIN Isoform 1 of Cysteine and glycine-rich protein 3 OS=Bos taurus OX=9913 GN=CSRP3 PE=2 SV=1 CANONICAL=Q4U0T9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S499-1", "url": "https://www.uniprot.org/uniprotkb/Q4U0T9/entry#A0AAA9S499-1", "sequence": { "sequence": "MSCSGELGQLPQEDTVEKGDVEVACRKALDSTTVAAHESEIYCKVCYGRRYGPKGIGYGQGAGCLSTDTGEHLGLQFQQSPKQARSATTSSNPSKFAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTGIGFGGLTHQVEKKD", "length": 179, "header": "tr|A0AAA9S499-1|CSRP3_BOVIN Computationally mapped isoform of Cysteine and glycine-rich protein 3 OS=Bos taurus OX=9913 GN=CSRP3 PE=2 SV=1 CANONICAL=Q4U0T9-1" }, "locus": { "chromosome": "29", "start_pos": 25764649, "end_pos": 25758074, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095746.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095746.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080762.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080762.1" } ] } }, { "isoform_ac": "Q4U0T9-1", "url": "https://www.uniprot.org/uniprotkb/Q4U0T9/entry#Q4U0T9-1", "sequence": { "sequence": "MPNWGGGAKCGACEKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRRYGPKGIGYGQGAGCLSTDTGEHLGLQFQQSPKQARSATTSSNPSKFAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTGIGFGGLTHQVEKKD", "length": 194, "header": "sp|Q4U0T9-1|CSRP3_BOVIN Isoform 1 of Cysteine and glycine-rich protein 3 OS=Bos taurus OX=9913 GN=CSRP3 PE=2 SV=1 CANONICAL=Q4U0T9-1" }, "locus": { "chromosome": "29", "start_pos": 25764649, "end_pos": 25754706, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030320.3", "url": "https://www.ensembl.org/id/ENSBTAT00000030320.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030304.1", "url": "https://www.ensembl.org/id/ENSBTAP00000030304.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 153, "end_pos": 153, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q4U0T9", "url": "https://www.uniprot.org/uniprotkb/Q4U0T9" } ], "site_lbl": "Ser153" }, { "start_pos": 95, "end_pos": 95, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q4U0T9", "url": "https://www.uniprot.org/uniprotkb/Q4U0T9" } ], "site_lbl": "Ser95" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Expression, SNV identification, linkage disequilibrium, and combined genotype association analysis of the muscle-specific gene CSRP3 in Chinese cattle.", "journal": "Gene", "date": "2014-02-01", "authors": "He Hua, Zhang Hui-Lin, Li Zhi-Xiong, Liu Yu, Liu Xiao-Lin", "evidence": [ { "database": "RefSeq", "id": "NP_001019860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019860" } ], "reference": [ { "type": "PubMed", "id": "24279998", "url": "https://glygen.org/publication/PubMed/24279998" } ] } ], "pathway": [ { "id": "bta:540407", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540407", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7HU10-1", "protein_name": "Cysteine and glycine-rich protein 3", "gene_name": "Csrp3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPNWGGGAKCGACEKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRRYGPKGIGFGQGAGCLSTDTGEHLGLQFQQSPKPARAATTSNPSKFSAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTGIGFGGLTQQVEKKE", "length": 194 }, "evidence": [ { "id": "Q4U0T9", "url": "https://omabrowser.org/oma/group/Q4U0T9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1NWZ2-1", "protein_name": "Cysteine and glycine rich protein 3", "gene_name": "CSRP3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPNWGGGAKCGACEKTVYHAEEIQCNGRSFHKTCFLCMACRKALDSTTVAAHESEIYCKTCYGRKYGPKGVGFGQGAGCLSTDTGDHLGLNLQQGSPKPARPSTPTNPSKFAKKMVDVDKCPRCGKSVYAAEKIMGGGKPWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKNFGPKGIGFGGLTQVEKKE", "length": 194 }, "evidence": [ { "id": "Q4U0T9", "url": "https://omabrowser.org/oma/group/Q4U0T9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1QJC0-1", "protein_name": "Cysteine and glycine-rich protein 1", "gene_name": "csrp3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPNWGGGAKCAACEKTVYHAEEIQCNSRSFHKTCFICMVCRKGLDSTTVAAHESEIYCKTCYGKKYGPKGYGYGQGAGALSSDPVNNEELQPQEPKAPRPAPANSNSSKFAQKFGSTDRCPRCSKAVYAAEKIMGAGKPWHKTCFRCLLCGKSLESTTVTDKDGELYCKVCYAKNFGPKGRGLGNPGMVEESV", "length": 193 }, "evidence": [ { "id": "Q4U0T9", "url": "https://omabrowser.org/oma/group/Q4U0T9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P50461-1", "protein_name": "Cysteine and glycine-rich protein 3", "gene_name": "CSRP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPNWGGGAKCGACEKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRRYGPKGIGYGQGAGCLSTDTGEHLGLQFQQSPKPARSVTTSNPSKFTAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTGIGFGGLTQQVEKKE", "length": 194 }, "evidence": [ { "id": "Q4U0T9", "url": "https://omabrowser.org/oma/group/Q4U0T9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P50462-1", "protein_name": "Cysteine and glycine-rich protein 3", "gene_name": "Csrp3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPNWGGGAKCGACEKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRRYGPKGIGFGQGAGCLSTDTGEHLGLQFQQSPKPARAATTSNPSKFSAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTGIGFGGLTQQVEKKE", "length": 194 }, "evidence": [ { "id": "Q4U0T9", "url": "https://omabrowser.org/oma/group/Q4U0T9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P50463-1", "protein_name": "Cysteine and glycine-rich protein 3", "gene_name": "Csrp3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPNWGGGAKCGACDKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRKYGPKGIGFGQGAGCLSTDTGEHLGLQFQQSPKPARAATTSNPSKFSAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFPCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTGIGFGGLTHQVEKKE", "length": 194 }, "evidence": [ { "id": "Q4U0T9", "url": "https://omabrowser.org/oma/group/Q4U0T9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "detection of muscle stretch", "id": "GO:0035995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035995", "evidence": [ { "database": "UniProtKB", "id": "Q4U0T9", "url": "https://www.uniprot.org/uniprotkb/Q4U0T9" } ], "pmid": "" }, { "name": "establishment of protein localization to 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"count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBV8-1", "uniprot_ac": "Q3ZBV8", "uniprot_id": "SYTC_BOVIN", "mass": { "chemical_mass": 83492.0, "monoisotopic_mass": 83492.0 }, "refseq": { "ac": "NP_001029542", "name": "threonine--tRNA ligase 1, cytoplasmic", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029542" }, "gene_names": [ { "name": "TARS1", "type": "recommended", "evidence": [ { "id": "Q3ZBV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8" } ] }, { "name": "TARS1", "type": "synonym", "evidence": [ { "id": "NP_001029542", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029542" } ] }, { "name": "TARS", "type": "synonym", "evidence": [ { "id": "NP_001029542", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029542" }, { "id": "Q3ZBV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8" } ] } ], "protein_names": [ { "name": "Threonine--tRNA ligase 1, cytoplasmic", "type": "recommended", "evidence": [ { "id": "Q3ZBV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8/entry#names_and_taxonomy" } ] }, { "name": "6.1.1.3", "type": "synonym", "evidence": [ { "id": "Q3ZBV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8/entry#names_and_taxonomy" } ] }, { "name": "ThrRS", "type": "synonym", "evidence": [ { "id": "Q3ZBV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8/entry#names_and_taxonomy" } ] }, { "name": "Threonine--tRNA ligase, cytoplasmic", "type": "synonym", "evidence": [ { "id": "Q3ZBV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8/entry#names_and_taxonomy" } ] }, { "name": "Threonyl-tRNA synthetase 1", "type": "synonym", "evidence": [ { "id": "Q3ZBV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8/entry#names_and_taxonomy" } ] }, { "name": "Threonyl-tRNA synthetase", "type": "synonym", "evidence": [ { "id": "Q3ZBV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8/entry#names_and_taxonomy" } ] }, { "name": "thrRS", "type": "synonym", "evidence": [ { "id": "NP_001029542", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029542" } ] }, { "name": "threonine--tRNA ligase 1, cytoplasmic", "type": "synonym", "evidence": [ { "id": "NP_001029542", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029542" } ] }, { "name": "threonine--tRNA ligase, cytoplasmic", "type": "synonym", "evidence": [ { "id": "NP_001029542", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029542" } ] }, { "name": "threonyl-tRNA synthetase, cytoplasmic", "type": "synonym", "evidence": [ { "id": "NP_001029542", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029542" } ] } ], "function": [ { "annotation": "Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). 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[ "Protein Classification" ] }, { "id": "IPR002320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004154", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004154", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012676", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012676", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012947", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012947", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018163", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033728", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033728", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036621", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036621", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045864", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045864", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047246", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047246", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510075", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510075", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MMNQRLW", "url": "https://omabrowser.org/oma/group/MMNQRLW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBV8", "url": "https://www.orthodb.org/?gene=Q3ZBV8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11451", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11451", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11451:SF36", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11451:SF36", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00587", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00587", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02824", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02824", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03129", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03129", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07973", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07973", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029542", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "24624", "url": "https://www.rhea-db.org/rhea/24624", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S5J7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5J7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5J7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5J7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBV8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBV8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEEQASSPSAKMGDEEKPVGAGEEKQKEGSKKKNKEGSGDGGRAELNPWPEYINTRLEMYNKLKAEHDSILAEKAEKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVIAKVNKAVWDLDRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIENGFYYDMYLEEGGVSSNDFSSLETLCKKIIKEKQAFERLEVKKETLLEMFKYNKFKCRILNEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKTLKIHKNSSTYWEGKSDMETLQRIYGISFPDPKMLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNTLIEFIRSEYRKRGFQEVVTPNIYNSRLWVTSGHWEHYSENMFSFEVEKELFALKPMNCPGHCLMFDHRPRSWRELPLRVADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSIFGFSFKLNLSTRPEKFLGDIEVWNQAEKQLENSLNDFGEKWELNPGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTFVSHDGDDKKKPVIIHRAILGSVERMIAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHNAKFMVDIDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKTSGTVNIRTRDNKVHGERTISETIERLQQLKHSRSKQAEEEF", "length": 723, "header": "sp|Q3ZBV8-1|SYTC_BOVIN Isoform 1 of Threonine--tRNA ligase 1, cytoplasmic OS=Bos taurus OX=9913 GN=TARS1 PE=2 SV=1 CANONICAL=Q3ZBV8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5J7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8/entry#A0AAA9S5J7-1", "sequence": { "sequence": "MSEEQASSPSAKMGDEEKPVGAGEEKQKEGSKKKNKEGSGDGGRAEGSGILLSSVGPGTESICS", "length": 64, "header": "tr|A0AAA9S5J7-1|SYTC_BOVIN Computationally mapped isoform of Threonine--tRNA ligase 1, cytoplasmic OS=Bos taurus OX=9913 GN=TARS1 PE=2 SV=1 CANONICAL=Q3ZBV8-1" }, "locus": { "chromosome": "20", "start_pos": 40332876, "end_pos": 40327005, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105479.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105479.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079128.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079128.1" } ] } }, { "isoform_ac": "A0AAA9TMW0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8/entry#A0AAA9TMW0-1", "sequence": { "sequence": "MSEEQASSPSAKMGDEEKPVGAGEEKQKEGSKKKNKEGSGDGGRAESRPGRQHCHC", "length": 56, "header": "tr|A0AAA9TMW0-1|SYTC_BOVIN Computationally mapped isoform of Threonine--tRNA ligase 1, cytoplasmic OS=Bos taurus OX=9913 GN=TARS1 PE=2 SV=1 CANONICAL=Q3ZBV8-1" }, "locus": { "chromosome": "20", "start_pos": 40332876, "end_pos": 40322198, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087987.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087987.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097685.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097685.1" } ] } }, { "isoform_ac": "Q3ZBV8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8/entry#Q3ZBV8-1", "sequence": { "sequence": "MSEEQASSPSAKMGDEEKPVGAGEEKQKEGSKKKNKEGSGDGGRAELNPWPEYINTRLEMYNKLKAEHDSILAEKAEKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVIAKVNKAVWDLDRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIENGFYYDMYLEEGGVSSNDFSSLETLCKKIIKEKQAFERLEVKKETLLEMFKYNKFKCRILNEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKTLKIHKNSSTYWEGKSDMETLQRIYGISFPDPKMLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNTLIEFIRSEYRKRGFQEVVTPNIYNSRLWVTSGHWEHYSENMFSFEVEKELFALKPMNCPGHCLMFDHRPRSWRELPLRVADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSIFGFSFKLNLSTRPEKFLGDIEVWNQAEKQLENSLNDFGEKWELNPGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTFVSHDGDDKKKPVIIHRAILGSVERMIAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHNAKFMVDIDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKTSGTVNIRTRDNKVHGERTISETIERLQQLKHSRSKQAEEEF", "length": 723, "header": "sp|Q3ZBV8-1|SYTC_BOVIN Isoform 1 of Threonine--tRNA ligase 1, cytoplasmic OS=Bos taurus OX=9913 GN=TARS1 PE=2 SV=1 CANONICAL=Q3ZBV8-1" }, "locus": { "chromosome": "20", "start_pos": 40332876, "end_pos": 40310065, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018947.5", "url": "https://www.ensembl.org/id/ENSBTAT00000018947.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018947.3", "url": "https://www.ensembl.org/id/ENSBTAP00000018947.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 629, "start_aa": "Thr", "end_pos": 629, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr629", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 246, "end_pos": 246, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8" } ], "site_lbl": "Thr246" }, { "start_pos": 298, "end_pos": 298, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8" } ], "site_lbl": "Tyr298" }, { "start_pos": 39, "end_pos": 39, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8" } ], "site_lbl": "Ser39" }, { "start_pos": 453, "end_pos": 453, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8" } ], "site_lbl": "Thr453" }, { "start_pos": 702, "end_pos": 702, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8" } ], "site_lbl": "Ser702" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:510075", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510075", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O04630-1", "protein_name": "Threonine--tRNA ligase, mitochondrial 1", "gene_name": "THRRS", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MLLRLTARSIRRFTTSSSSLPLLSSSSFCTVPTMAANHPKDEAYLSAVIPKRIKLFEQIQANQLENLKSLPHDPIKVTLPDGNVKEGKKWETTPMDIAAQISKGLANSALISAVDDVLWDMNRPLEGDCKLELFKFDSDKGRDTLWHSSAHILGQALEQEYGCQLCIGPCTTRGEGFYYDGFYGELGLSDNHFPSIEAGAAKAAKEAQPFERIEVTKDQALEMFSENNFKVELINGLPADMTITVYRCGPLVDLCRGPHIPNTSFVKAFKCLRASSAYWKGDKDRESLQRVYGISYPDQKQLKKYLQFLEEAKKYDHRLLGQKQELFFSHQLSPGSYFFLPLGTRVYNRLMDFIKNQYWHRGYTEVITPNMYNMELWQTSGHADNYKDNMFTFNIEKQEFGLKPMNCPGHCLIFQHRVRSYRELPMRLADFGVLHRNEASGALSGLTRVRRFQQDDAHIFCTTEQVKGEVQGVLEFIDYVYKVFGFTYELKLSTRPEKYLGDLETWDKAEADLKEAIEAFGKPLVLNEGDGAFYGPKIDITVSDAMNRKFQCATLQLDFQLPIRFNLEYAAEDEAKKSRPVMIHRAVLGSVERMFAILLEHYKGKWPFWISPRQAIVCPISEKSQQYAEKVQKQIKDAGFYVDADLTDRKIDKKVREAQLAQYNYILVVGETEAATGQVSVRVRDNAAHSVKSIEDLLEEFKAKTAEFV", "length": 709 }, "evidence": [ { "id": "Q3ZBV8", "url": "https://omabrowser.org/oma/group/Q3ZBV8/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P26639-1", "protein_name": "Threonine--tRNA ligase 1, cytoplasmic", "gene_name": "TARS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFEEKASSPSGKMGGEEKPIGAGEEKQKEGGKKKNKEGSGDGGRAELNPWPEYIYTRLEMYNILKAEHDSILAEKAEKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVIAKVNNVVWDLDRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIENGFYYDMYLEEGGVSSNDFSSLEALCKKIIKEKQAFERLEVKKETLLAMFKYNKFKCRILNEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKALKIHKNSSTYWEGKADMETLQRIYGISFPDPKMLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNALIEFIRSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSVFGFSFKLNLSTRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERMIAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRSKQAEEEF", "length": 723 }, "evidence": [ { "id": "Q3ZBV8", "url": "https://omabrowser.org/oma/group/Q3ZBV8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5XHY5-1", "protein_name": "Threonine--tRNA ligase 1, cytoplasmic", "gene_name": "Tars1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSEEKASSPSGKMDGEKPLNPWPEYINTRLDMYHKLKAEHDSILAEKAAKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVVAKVNKVVWDLDRPLETDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIENGFYYDMYLEEGGVSSNDFSSLETLCKKIIKEKQTFERLEVKKETLLEMFKYNKFKCRILNEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKTLKIHKNSSTYWEGKADMETLQRIYGISFPDPKLLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNTLMEFIRSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKEQFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSVFGFSFKLNLSTRPEKFLGDIEIWNQAEKQLENSLNEFGEKWELNPGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERMIAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQEFHDAKFMVDIDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKASGTVNIRTRDNKVHGERTVGETVERLQQLKQLRSKQAEEEF", "length": 695 }, "evidence": [ { "id": "Q3ZBV8", "url": "https://omabrowser.org/oma/group/Q3ZBV8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D0R2-1", "protein_name": "Threonine--tRNA ligase 1, cytoplasmic", "gene_name": "Tars1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSQEKASSPSGKMDGEKPVDASEEKRKEGGKKKSKDGGGDGGRAELNPWPEYINTRLDMYNKLKAEHDSILAEKAAKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVVAKVNKVVWDLDRPLETDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIENGFYYDMYLEEGGVSSNDFSSLETLCKKIIKEKQTFERLEVKKETLLEMFKYNKFKCRILNEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKTLKIHKNSSTYWEGKADMETLQRIYGISFPDPKLLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNTLMEFIRSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKEQFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSVFGFSFKLNLSTRPEKFLGDIEIWNQAEKQLENSLNEFGEKWELNPGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERMIAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADTDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKASGTVNIRTRDNKVHGERTVEETVRRLQQLKQTRSKQAEEEF", "length": 722 }, "evidence": [ { "id": "Q3ZBV8", "url": "https://omabrowser.org/oma/group/Q3ZBV8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VKB0-1", "protein_name": "threonine--tRNA ligase", "gene_name": "ThrRS", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLKLAPQGGRYYSQISRICQWILPKIQTQSKPPKQQQQQQPQLKEQQQHSYATLAAKMKKEKKEKPSGGGDTRKELSPLPKYIEERNVFWEKCKAEYEAELAAKKREPIKVTLPDGKQVDATSWETTPYEVARGISQGLADNTVISKVNGEVWDLDRVLEGNCTLQLLKFDDPEAQAVFWHSSAHIMGEAMERIYGGHLCYGPPIENGFYYDMHLEGEGISTNDYGAMEGLVKQIVKEKQNFERLEMKKSDLLEMFKYNEFKVRILNEKVTTDRTTVYKCGSLIDLCRGPHVRHTGKVKALKITKNSSTYWEGKADAETLQRVYGISFPDPKQLKEWEKLQEEAAKRDHRKIGREQELFFFHELSPGSCFFQPRGAHIYNTLMGFIKAEYRKRGFQEVISPNIYNAKLWMTSGHWQHYAENMFSFEAEKEKFALKPMNCPGHCLIFDNRNRSWRELPLRMADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAPEQIKSEMKGCLEFLKYVYTIFGFSFQLVLSTRPDNYLGELEQWNDAEKALAESLNEFGMPWKENPGDGAFYGPKIDITIMDALKRAHQCATIQLDFQLPIRFNLSYIADDGEKKRPVIIHRAILGSVERMIAILTENFAGKWPFWLSPRQVMVVPVGPAYDQYAQSVRDQLHDAGFMSEADCDAGDTMNKKIRNAQLAQFNFILVVGDKERSSNTVNVRTRDNKVHGEVSVAELITKLQKIRDEFIANEDSF", "length": 747 }, "evidence": [ { "id": "Q3ZBV8", "url": "https://omabrowser.org/oma/group/Q3ZBV8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8" } ], "pmid": "" }, { "name": "threonine-tRNA ligase activity", "id": "GO:0004829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "threonyl-tRNA aminoacylation", "id": "GO:0006435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006435", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 280, "end_pos": 282, "annotation": "n_glycosylation_sequon" }, { "start_pos": 497, "end_pos": 499, "annotation": "n_glycosylation_sequon" }, { "start_pos": 572, "end_pos": 574, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "24624", "name": "", "equation": "tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S7D5-1", "A6QNM8-1", "Q3ZBV8-1" ], "evidence": [ { "id": "24624", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24624" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9S7D5", "gene_name": "TARS2", "activity": [ { "ec_number": "6.1.1.3", "activity": "tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+).", "evidence": [ { "id": "A0AAA9S7D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5" } ] }, { "ec_number": "6.1.1.3", "activity": "", "evidence": [ { "id": "A0AAA9S7D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7D5" } ] } ] }, { "uniprot_ac": "A6QNM8", "gene_name": "TARS3", "activity": [ { "ec_number": "6.1.1.3", "activity": "tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+).", "evidence": [ { "id": "A6QNM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM8" } ] }, { "ec_number": "6.1.1.3", "activity": "", "evidence": [ { "id": "A6QNM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNM8" } ] } ] }, { "uniprot_ac": "Q3ZBV8", "gene_name": "TARS1", "activity": [ { "ec_number": "6.1.1.3", "activity": "tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+).", "evidence": [ { "id": "Q3ZBV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8" } ] }, { "ec_number": "6.1.1.3", "activity": "", "evidence": [ { "id": "Q3ZBV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBV8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 723, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBV8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBV8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZBV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV8" }, { "id": "PRU01228", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01228" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TGS", "eco_id": "ECO_0000255", "start_pos": 79, "end_pos": 143, "start_aa": "Asp", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.1.1.3", "ec_name": "tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+).", "evidence": [ { "id": "6.1.1.3", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.3" }, { "id": "6.1.1.3", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.1.1.3" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 629 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 39, 246, 298, 453, 702 ], "sequon_annotation_sites": [ { "start_pos": 280, "end_pos": 282 }, { "start_pos": 497, "end_pos": 499 }, { "start_pos": 572, "end_pos": 574 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q58DU5-1", "uniprot_ac": "Q58DU5", "uniprot_id": "PSA3_BOVIN", "mass": { "chemical_mass": 28405.0, "monoisotopic_mass": 28405.0 }, "refseq": { "ac": "NP_001029407", "name": "proteasome subunit alpha type-3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029407" }, "gene_names": [ { "name": "PSMA3", "type": "recommended", "evidence": [ { "id": "Q58DU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DU5" } ] }, { "name": "PSMA3", "type": "synonym", "evidence": [ { "id": "NP_001029407", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029407" } ] } ], "protein_names": [ { "name": "Proteasome subunit alpha type-3", "type": "recommended", "evidence": [ { "id": "Q58DU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DU5/entry#names_and_taxonomy" } ] }, { "name": "proteasome (prosome, macropain) subunit, alpha type, 3", "type": "synonym", "evidence": [ { "id": "NP_001029407", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029407" } ] }, { "name": "proteasome alpha 3 subunit", "type": "synonym", "evidence": [ { "id": "NP_001029407", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029407" } ] }, { "name": "proteasome subunit alpha 3", "type": "synonym", "evidence": [ { "id": "NP_001029407", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029407" } ] }, { "name": "proteasome subunit alpha type-3", "type": "synonym", "evidence": [ { "id": "NP_001029407", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029407" } ] } ], "function": [ { "annotation": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. 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CANONICAL=Q58DU5-1" }, "locus": { "chromosome": "10", "start_pos": 70576246, "end_pos": 70551851, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094648.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094648.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080983.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080983.1" } ] } }, { "isoform_ac": "A0AAA9TFB5-1", "url": "https://www.uniprot.org/uniprotkb/Q58DU5/entry#A0AAA9TFB5-1", "sequence": { "sequence": "MSSLSSTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDVVKEVAKIIYIVHDEVKDKAFELELSWVGEITNGRHEIVPKDVREEAEKYAKESLKEEDESDDDNM", "length": 248, "header": "tr|A0AAA9TFB5-1|PSA3_BOVIN Computationally mapped isoform of Proteasome subunit alpha type-3 OS=Bos taurus OX=9913 GN=PSMA3 PE=1 SV=1 CANONICAL=Q58DU5-1" }, "locus": { "chromosome": "10", "start_pos": 70576246, 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"ENSBTAT00000003636.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003636.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003636.4", "url": "https://www.ensembl.org/id/ENSBTAP00000003636.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 243, "end_pos": 243, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DU5", "url": "https://www.uniprot.org/uniprotkb/Q58DU5" } ], "site_lbl": "Ser243" }, { "start_pos": 250, "end_pos": 250, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DU5", "url": "https://www.uniprot.org/uniprotkb/Q58DU5" } ], "site_lbl": "Ser250" } ], "glycation": [], "keywords": [], "publication": [ { "title": "The structure of the mammalian 20S proteasome at 2.75 A resolution.", "journal": "Structure", "date": "2002", "authors": "Unno Masaki, Mizushima Tsunehiro, Morimoto Yukio, Tomisugi Yoshikazu, Tanaka Keiji, Yasuoka Noritake, Tsukihara Tomitake", "evidence": [ { "database": "UniProtKB", "id": "Q58DU5", "url": "https://www.uniprot.org/uniprotkb/Q58DU5" } ], "reference": [ { "type": "PubMed", "id": "12015144", "url": "https://glygen.org/publication/PubMed/12015144" } ] }, { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DU5", "url": "https://www.uniprot.org/uniprotkb/Q58DU5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:505176", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505176", "resource": "KEGG 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"resource": "Reactome", "description": "ABC-family protein mediated transport" }, { "id": "R-BTA-450408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450408", "resource": "Reactome", "description": "AUF1 (hnRNP D0) binds and destabilizes mRNA" }, { "id": "R-BTA-4608870", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4608870", "resource": "Reactome", "description": "Asymmetric localization of PCP proteins" }, { "id": "R-BTA-4641257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641257", "resource": "Reactome", "description": "Degradation of AXIN" }, { "id": "R-BTA-4641258", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641258", "resource": "Reactome", "description": "Degradation of DVL" }, { "id": "R-BTA-5358346", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5358346", "resource": "Reactome", "description": "Hedgehog ligand biogenesis" }, { "id": "R-BTA-5607761", "name": "", 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"glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P21242-1", "protein_name": "Probable proteasome subunit alpha type-7", "gene_name": "PRE10", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTSIGTGYDLSNSVFSPDGRNFQVEYAVKAVENGTTSIGIKCNDGVVFAVEKLITSKLLVPQKNVKIQVVDRHIGCVYSGLIPDGRHLVNRGREEAASFKKLYKTPIPIPAFADRLGQYVQAHTLYNSVRPFGVSTIFGGVDKNGAHLYMLEPSGSYWGYKGAATGKGRQSAKAELEKLVDHHPEGLSAREAVKQAAKIIYLAHEDNKEKDFELEISWCSLSETNGLHKFVKGDLLQEAIDFAQKEINGDDDEDEDDSDNVMSSDDENAPVATNANATTDQEGDIHLE", "length": 288 }, "evidence": [ { "id": "Q58DU5", "url": "https://omabrowser.org/oma/group/Q58DU5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P25788-1", "protein_name": "Proteasome subunit alpha type-3", "gene_name": "PSMA3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYAKESLKEEDESDDDNM", "length": 255 }, "evidence": [ { "id": "Q58DU5", "url": "https://omabrowser.org/oma/group/Q58DU5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q27563-1", "protein_name": "Proteasome subunit alpha type-3", "gene_name": "psmA3", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSSVGSGYDLYVSTYSPDGKLFQVDYANKAVENSGTLVAIKAKDGVVLGVEKLVPSKMLCSGSNRRVHHIDTHVGVAIAGFLADARQLITRARSEAKNYKSTYGQPIPIKVLSQRIASYNHMHTLYGSVRPFGCSIAITGIDQYGPQLFLVEPSGSCVGYFGASLGKGKQAAKNELEKIKFSEMTCREAIKEVSRIIYSVHDEVKDKDFELELGWISTETNNVHQIVPKELHDEAEAYAKQSLEDANM", "length": 248 }, "evidence": [ { "id": "Q58DU5", "url": "https://omabrowser.org/oma/group/Q58DU5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9V5C6-1", "protein_name": "Proteasome subunit alpha type-3", "gene_name": "Prosalpha7", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSTIGTGYDLSASQFSPDGRVFQIDYASKAVEKSGTVIGIRGKDAVVLAVEKIITSKLYEPDAGGRIFTIEKNIGMAVAGLVADGNFVADIARQEAANYRQQFEQAIPLKHLCHRVAGYVHAYTLYSAVRPFGLSIILASWDEVEGPQLYKIEPSGSSFGYFACASGKAKQLAKTEMEKLKMDMRTDELVESAGEIIYKVHDELKDKDFRFEMGLVGRVTGGLHLINPSELTEKARKAGDAANKDEDSDNETH", "length": 253 }, "evidence": [ { "id": "Q58DU5", "url": "https://omabrowser.org/oma/group/Q58DU5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q58DU5", "url": "https://www.uniprot.org/uniprotkb/Q58DU5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q58DU5", "url": "https://www.uniprot.org/uniprotkb/Q58DU5" } ], "pmid": "" }, { "name": "proteasome core complex, alpha-subunit complex", "id": "GO:0019773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019773", "evidence": [ { "database": "UniProtKB", "id": "Q58DU5", "url": "https://www.uniprot.org/uniprotkb/Q58DU5" } ], "pmid": "" }, { "name": "proteasome core complex", "id": "GO:0005839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005839", "evidence": [ { "database": "UniProtKB", "id": "Q58DU5", "url": "https://www.uniprot.org/uniprotkb/Q58DU5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q58DU5", "url": "https://www.uniprot.org/uniprotkb/Q58DU5" } ], "pmid": "" }, { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "Q58DU5", "url": "https://www.uniprot.org/uniprotkb/Q58DU5" } ], "pmid": "" }, { "name": "regulation of proteasomal protein catabolic process", "id": "GO:0061136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061136", "evidence": [ { "database": "UniProtKB", "id": "Q58DU5", "url": "https://www.uniprot.org/uniprotkb/Q58DU5" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "Q58DU5", "url": "https://www.uniprot.org/uniprotkb/Q58DU5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "Q58DU5", "url": "https://www.uniprot.org/uniprotkb/Q58DU5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DU5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 255, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DU5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DU5" }, { "pdb_id": "1iru", "pdb_chain": "g/u", "start_pos": 2, "end_pos": 255, "overlap": "1.0", "method": "X-Ray_Crystallography", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/1iru.pdb", "url_external": "https://www.rcsb.org/structure/1iru" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 243, 250 ], "sequon_annotation_sites": [ { "start_pos": 33, "end_pos": 35 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DN4-1", "uniprot_ac": "Q58DN4", "uniprot_id": "PPME1_BOVIN", "mass": { "chemical_mass": 41710.0, "monoisotopic_mass": 41710.0 }, "refseq": { "ac": "NP_001069524", "name": "protein phosphatase methylesterase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069524" }, "gene_names": [ { "name": "PPME1", "type": "recommended", "evidence": [ { "id": "Q58DN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN4" } ] }, { "name": "PME1MGC133824", "type": "synonym", "evidence": [ { "id": "NP_001069524", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069524" } ] }, { "name": "PME1", "type": "synonym", "evidence": [ { "id": "Q58DN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN4" } ] }, { "name": "PPME1", "type": "synonym", "evidence": [ { "id": "NP_001069524", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069524" } ] } ], "protein_names": [ { "name": "Protein phosphatase methylesterase 1", "type": "recommended", "evidence": [ { "id": "Q58DN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN4/entry#names_and_taxonomy" } ] }, { "name": "3.1.1.89", "type": "synonym", "evidence": [ { "id": "Q58DN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN4/entry#names_and_taxonomy" } ] }, { "name": "PME-1", "type": "synonym", "evidence": [ { "id": "NP_001069524", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069524" }, { "id": "Q58DN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN4/entry#names_and_taxonomy" } ] }, { "name": "protein phosphatase methylesterase 1", "type": "synonym", "evidence": [ { "id": "NP_001069524", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069524" } ] } ], "function": [ { "annotation": "Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9J1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9J1#function" }, { "database": "UniProtKB", "id": "ARBA00024698", "url": "https://www.uniprot.org/uniprotkb/ARBA00024698#function" }, { "database": "UniProtKB", "id": "Q58DN4", "url": "https://www.uniprot.org/uniprotkb/Q58DN4#function" }, { "database": "UniProtKB", "id": "A0ABI0NNG0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNG0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DN4", "url": "https://www.uniprot.org/uniprotkb/Q58DN4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPME1", "url": "https://www.uniprot.org/uniprotkb/Q58DN4", "locus": { "chromosome": "15", "start_pos": 53631288, "end_pos": 53580198, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027612", "url": "https://www.ensembl.org/id/ENSBTAG00000027612" } ] } } ], "crossref": [ { "id": "Q58DN4", "url": "https://alphafold.ebi.ac.uk/entry/Q58DN4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027612", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027612", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "535390", "url": "https://www.ncbi.nlm.nih.gov/gene/535390", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000639", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000639", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016812", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016812", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535390", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535390", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VMVCHHG", "url": "https://omabrowser.org/oma/group/VMVCHHG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DN4", "url": "https://www.orthodb.org/?gene=Q58DN4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14189", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14189", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14189:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14189:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00561", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00561", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12697", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12697", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-69273", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69273", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001069524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069524", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "48548", "url": "https://www.rhea-db.org/rhea/48548", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S9J1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9J1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9J1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9J1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NNG0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NNG0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNG0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DN4", "url": "https://www.uniprot.org/uniprotkb/Q58DN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DN4-1", "url": "https://www.uniprot.org/uniprotkb/Q58DN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFSPVPWSQYFESMEDVEVENETGKDTFRVYKSGSEGPVLLLLHGGGHSALSWAVFTAAIISRVQCRIVALDLRGHGETKVRNSEDLSAETMAKDVGNVVEAMYGDLPPPIMLIGHSMGGAIAVHTASSNLVPSLLGLCMIDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESVNKRKKEDDMETKKDHPYTWRIELAKTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQ", "length": 380, "header": "sp|Q58DN4-1|PPME1_BOVIN Isoform 1 of Protein phosphatase methylesterase 1 OS=Bos taurus OX=9913 GN=PPME1 PE=2 SV=3 CANONICAL=Q58DN4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9J1-1", "url": "https://www.uniprot.org/uniprotkb/Q58DN4/entry#A0AAA9S9J1-1", "sequence": { "sequence": "MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFSPVPWSQYFESMEDVEVENETGKDTFRVYKSGSEGPVLLLLHGGGHSALSWAVFTAAIISRVQCRIVALDLRGHGETKVRNSEDLSAETMAKDVGNVVEAMYGDLPPPIMLIGHSMGGAIAVHTASSNLVPSLLGLCMIDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESVNKRKKEDDMEGLPSETQNLLLLLQTKKDHPYTWRIELAKTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQCVFPGC", "length": 400, "header": "tr|A0AAA9S9J1-1|PPME1_BOVIN Computationally mapped isoform of Protein phosphatase methylesterase 1 OS=Bos taurus OX=9913 GN=PPME1 PE=2 SV=1 CANONICAL=Q58DN4-1" }, "locus": { "chromosome": "15", "start_pos": 53630284, "end_pos": 53580321, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128836.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128836.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082751.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082751.1" } ] } }, { "isoform_ac": "A0ABI0NNG0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DN4/entry#A0ABI0NNG0-1", "sequence": { "sequence": "MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFSPVPWSQYFESMEDVEVENETGKDISFSGSEGPVLLLLHGGGHSALSWAVFTAAIISRVQCRIVALDLRGHGETKVRNSEDLSAETMAKDVGNVVEAMYGDLPPPIMLIGHSMGGAIAVHTASSNLVPSLLGLCMIDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESVNKRKKEDDMETKKDHPYTWRIELAKTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQW", "length": 378, "header": "tr|A0ABI0NNG0-1|A0ABI0NNG0_BOVIN Computationally mapped isoform of Protein phosphatase methylesterase 1 OS=Bos taurus OX=9913 GN=PPME1 PE=3 SV=1 CANONICAL=Q58DN4-1" }, "locus": { "chromosome": "15", "start_pos": 53628936, "end_pos": 53580321, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147307.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147307.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106898.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106898.1" } ] } }, { "isoform_ac": "Q58DN4-1", "url": "https://www.uniprot.org/uniprotkb/Q58DN4/entry#Q58DN4-1", "sequence": { "sequence": "MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFSPVPWSQYFESMEDVEVENETGKDTFRVYKSGSEGPVLLLLHGGGHSALSWAVFTAAIISRVQCRIVALDLRGHGETKVRNSEDLSAETMAKDVGNVVEAMYGDLPPPIMLIGHSMGGAIAVHTASSNLVPSLLGLCMIDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESVNKRKKEDDMETKKDHPYTWRIELAKTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQ", "length": 380, "header": "sp|Q58DN4-1|PPME1_BOVIN Isoform 1 of Protein phosphatase methylesterase 1 OS=Bos taurus OX=9913 GN=PPME1 PE=2 SV=3 CANONICAL=Q58DN4-1" }, "locus": { "chromosome": "15", "start_pos": 53628935, "end_pos": 53580321, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039760.7", "url": "https://www.ensembl.org/id/ENSBTAT00000039760.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039548.4", "url": "https://www.ensembl.org/id/ENSBTAP00000039548.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 15, "end_pos": 15, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DN4", "url": "https://www.uniprot.org/uniprotkb/Q58DN4" } ], "site_lbl": "Ser15" }, { "start_pos": 42, "end_pos": 42, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DN4", "url": "https://www.uniprot.org/uniprotkb/Q58DN4" } ], "site_lbl": "Ser42" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DN4", "url": "https://www.uniprot.org/uniprotkb/Q58DN4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:535390", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535390", "resource": "KEGG Pathway" }, { "id": "R-BTA-69273", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69273", "resource": "Reactome", "description": "Cyclin A/B1/B2 associated events during G2/M transition" } ], "orthologs": [ { "uniprot_canonical_ac": "P38796-1", "protein_name": "Protein phosphatase methylesterase 1", "gene_name": "PPE1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSDDLRRKIALSQFERAKNVLDATFQEAYEDDENDGDALGSLPSFNGQSNRNRKYTGKTGSTTDRISSKEKSSLPTWSDFFDNKELVSLPDRDLDVNTYYTLPTSLLSNTTSIPIFIFHHGAGSSGLSFANLAKELNTKLEGRCGCFAFDARGHAETKFKKADAPICFDRDSFIKDFVSLLNYWFKSKISQEPLQKVSVILIGHSLGGSICTFAYPKLSTELQKKILGITMLDIVEEAAIMALNKVEHFLQNTPNVFESINDAVDWHVQHALSRLRSSAEIAIPALFAPLKSGKVVRITNLKTFSPFWDTWFTDLSHSFVGLPVSKLLILAGNENLDKELIVGQMQGKYQLVVFQDSGHFIQEDSPIKTAITLIDFWKRNDSRNVVIKTNWGQHKTVQNT", "length": 400 }, "evidence": [ { "id": "Q58DN4", "url": "https://omabrowser.org/oma/group/Q58DN4/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q4FZT2-1", "protein_name": "Protein phosphatase methylesterase 1", "gene_name": "Ppme1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFTPVPWSQYFESMEDVEVENETGKDTFRVYKSGSEGPVLLLLHGGGHSALSWAVFTAAIISRVQCRIVALDLRSHGETKVKNSEDLSAETMAKDVGNVVEAMYGDLPPPVMLIGHSMGGAIAVHTAAANLVPSLLGLCMIDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEGITSPESSKSIVEGIIEEEEEDEEGSESVNKRKKEDDMETKKDHPYTWRIELAKTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQCVFPGC", "length": 386 }, "evidence": [ { "id": "Q58DN4", "url": "https://omabrowser.org/oma/group/Q58DN4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q54TN3-1", "protein_name": "Probable protein phosphatase methylesterase 1", "gene_name": "ppme1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFRGIYKGSLPPIDPSSIHHGESLADQLQDKDYYSVGWNQYFDQSRDIKLPGTENTFRIYESNVDVVDNGYLFVFLHGGGYTSLSWSLVVDKIKKKNLEKKVRMMCYDCRGHGETKTSDDSNLSIETMVDDCANLINYYQDIIYKNEGGGGGNDDDDQKERLKVIIVGHSMGGSVVIKTSSTNRINNLFGLIVIDVVEGTALLALSSMKSILAKRPKSFDSVKDAIKWSISSNTVKNIESARVSLYFINNFFFFFLTDWFSGLSKEFLSSMALKLLILAGTDRLDRELTIAQMQGKFQLILLPLCGHVIQEDVPTGPKINI", "length": 321 }, "evidence": [ { "id": "Q58DN4", "url": "https://omabrowser.org/oma/group/Q58DN4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8BVQ5-1", "protein_name": "Protein phosphatase methylesterase 1", "gene_name": "Ppme1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFTPVPWSQYFESMEDVEVENETGKDTFRVYKSGSEGPVLLLLHGGGHSALSWAVFTAAIISRVQCRIVALDLRGHGETKVKNSEDLSAETMAKDVGNVVEAMYGDLPPPVMLIGHSMGGAIAVHTAAANLVPSLLGLCMIDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESVNKRKKEDDMETKKDHPYTWRIELAKTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQCVFPGC", "length": 386 }, "evidence": [ { "id": "Q58DN4", "url": "https://omabrowser.org/oma/group/Q58DN4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y570-1", "protein_name": "Protein phosphatase methylesterase 1", "gene_name": "PPME1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFSPVPWSQYFESMEDVEVENETGKDTFRVYKSGSEGPVLLLLHGGGHSALSWAVFTAAIISRVQCRIVALDLRSHGETKVKNPEDLSAETMAKDVGNVVEAMYGDLPPPIMLIGHSMGGAIAVHTASSNLVPSLLGLCMIDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESISKRKKEDDMETKKDHPYTWRIELAKTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQCVFPGC", "length": 386 }, "evidence": [ { "id": "Q58DN4", "url": "https://omabrowser.org/oma/group/Q58DN4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein phosphatase 2A binding", "id": "GO:0051721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051721", "evidence": [ { "database": "UniProtKB", "id": "Q58DN4", "url": "https://www.uniprot.org/uniprotkb/Q58DN4" } ], "pmid": "" }, { "name": "protein methylesterase activity", "id": "GO:0051723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051723", "evidence": [ { "database": "UniProtKB", "id": "Q58DN4", "url": "https://www.uniprot.org/uniprotkb/Q58DN4" } ], "pmid": "" }, { "name": "protein phosphatase inhibitor activity", "id": "GO:0004864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004864", "evidence": [ { "database": "UniProtKB", "id": "Q58DN4", "url": "https://www.uniprot.org/uniprotkb/Q58DN4" } ], "pmid": "" }, { "name": "lncRNA binding", "id": "GO:0106222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106222", "evidence": [ { "database": "UniProtKB", "id": "Q58DN4", "url": "https://www.uniprot.org/uniprotkb/Q58DN4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "Q58DN4", "url": "https://www.uniprot.org/uniprotkb/Q58DN4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 60, "end_pos": 62, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "48548", "name": "", "equation": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q58DN4-1" ], "evidence": [ { "id": "48548", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48548" } ] }, { "id": "R-BTA-8856951", "name": "PP2A demethylation by PPME1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-ALL-8857797" ], "enzyme_list": [ "P67774-1", "Q0P594-1", "Q58DN4-1" ], "evidence": [ { "id": "R-BTA-8856951", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856951" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-8857797", "participant_name": "methanol [nucleoplasm]", "crossref": [ { "id": "C00132", "database": "COMPOUND", "url": "" }, { "id": "17790", "database": "ChEBI", "url": "" }, { "id": "HMDB0001875", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "P67774", "gene_name": "PPP2CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] } ] }, { "uniprot_ac": "Q0P594", "gene_name": "PPP2CB", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] } ] }, { "uniprot_ac": "Q58DN4", "gene_name": "PPME1", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q58DN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN4" } ] }, { "ec_number": "3.1.1.89", "activity": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+).", "evidence": [ { "id": "Q58DN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN4" } ] }, { "ec_number": "3.1.1.89", "activity": "", "evidence": [ { "id": "Q58DN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DN4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 380, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DN4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DN4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.1.89", "ec_name": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+).", "evidence": [ { "id": "3.1.1.89", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.89" }, { "id": "3.1.1.89", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.89" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 15, 42 ], "sequon_annotation_sites": [ { "start_pos": 60, "end_pos": 62 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5BIP7-1", "uniprot_ac": "Q5BIP7", "uniprot_id": "LIAS_BOVIN", "mass": { "chemical_mass": 42035.0, "monoisotopic_mass": 42035.0 }, "refseq": { "ac": "NP_001017944", "name": "lipoyl synthase, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017944" }, "gene_names": [ { "name": "LIAS", "type": "recommended", "evidence": [ { "id": "Q5BIP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7" } ] }, { "name": "LIAS", "type": "synonym", "evidence": [ { "id": "NP_001017944", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017944" } ] } ], "protein_names": [ { "name": "Lipoyl synthase, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q5BIP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7/entry#names_and_taxonomy" } ] }, { "name": "2.8.1.8", "type": "synonym", "evidence": [ { "id": "Q5BIP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7/entry#names_and_taxonomy" } ] }, { "name": "LS", "type": "synonym", "evidence": [ { "id": "NP_001017944", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017944" }, { "id": "Q5BIP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7/entry#names_and_taxonomy" } ] }, { "name": "Lip-syn", "type": "synonym", "evidence": [ { "id": "Q5BIP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7/entry#names_and_taxonomy" } ] }, { "name": "Lipoate synthase", "type": "synonym", "evidence": [ { "id": "Q5BIP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7/entry#names_and_taxonomy" } ] }, { "name": "Lipoic acid synthase", "type": "synonym", "evidence": [ { "id": "Q5BIP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7/entry#names_and_taxonomy" } ] }, { "name": "lip-syn", "type": "synonym", "evidence": [ { "id": "NP_001017944", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017944" } ] }, { "name": "lipoate synthase", "type": "synonym", "evidence": [ { "id": "NP_001017944", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017944" } ] }, { "name": "lipoic acid synthase", "type": "synonym", "evidence": [ { "id": "NP_001017944", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017944" } ] }, { "name": "lipoyl synthase, mitochondrial precursor", "type": "synonym", "evidence": [ { "id": "NP_001017944", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017944" } ] }, { "name": "lipoyl synthase, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001017944", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017944" } ] } ], "function": [ { "annotation": "Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SI71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI71#function" }, { "database": "HAMAP", "id": "MF_03123", "url": "https://hamap.expasy.org/signature/MF_03123" }, { "database": "UniProtKB", "id": "A0AAA9SPT8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT8#function" }, { "database": "UniProtKB", "id": "A0AAA9SRH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRH8#function" }, { "database": "UniProtKB", "id": "Q5BIP7", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5BIP7", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LIAS", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7", "locus": { "chromosome": "6", "start_pos": 58581438, "end_pos": 58569574, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014520", "url": "https://www.ensembl.org/id/ENSBTAG00000014520" } ] } } ], "crossref": [ { "id": "Q5BIP7", "url": "https://alphafold.ebi.ac.uk/entry/Q5BIP7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014520", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014520", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01335", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01335", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "530865", "url": "https://www.ncbi.nlm.nih.gov/gene/530865", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003698", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003698", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007197", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031691", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058240", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058240", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530865", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530865", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PYCDIDF", "url": "https://omabrowser.org/oma/group/PYCDIDF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5BIP7", "url": "https://www.orthodb.org/?gene=Q5BIP7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10949", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10949", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10949:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10949:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04055", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04055", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16881", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16881", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9857492", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9857492", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001017944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017944", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16585", "url": "https://www.rhea-db.org/rhea/16585", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S9V1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9V1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPT8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPT8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRH8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRH8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRH8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG25-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLN4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BIP7", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BIP7-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLRCGGAVRTVGPRVFGRYVFSPVREVSFLPDEKKEFLQSGPDLQEFISGNLADKSTWDEYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDANEPYNTAKAIAEWGLDYVVLTSVDRDDMPDGGAEHFAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQRKVRDPRANFDQSLRVLKHAKEVRPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTKRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYKAGEFFLKNLVAKRKTKAL", "length": 372, "header": "sp|Q5BIP7-1|LIAS_BOVIN Isoform 1 of Lipoyl synthase, mitochondrial OS=Bos taurus OX=9913 GN=LIAS PE=2 SV=1 CANONICAL=Q5BIP7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9V1-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7/entry#A0AAA9S9V1-1", "sequence": { "sequence": "MSLRCGGAVRTVGPRVFGRYVFSPVREVSFLPDEKKEFLQSGPDLQEFISGNLADKSTWDEYKGNLKRQKGERCVRKLDVPILESVGEVENMLPPQPQSWKVRDPRANFDQSLRVLKHAKEVRPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTKRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYKAGEFFLKNLVAKRKTKAL", "length": 226, "header": "tr|A0AAA9S9V1-1|LIAS_BOVIN Computationally mapped isoform of Lipoyl synthase, mitochondrial OS=Bos taurus OX=9913 GN=LIAS PE=2 SV=1 CANONICAL=Q5BIP7-1" }, "locus": { "chromosome": "6", "start_pos": 58581145, "end_pos": 58569644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123252.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123252.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078925.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078925.1" } ] } }, { "isoform_ac": "A0AAA9SI71-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7/entry#A0AAA9SI71-1", "sequence": { "sequence": "IRIKCGIYVFSPVREVSFLPDEKKEFLQSGPDLQEFISGNLADKSTWDEYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDANEPYNTAKAIAEWGLDYVVLTSVDRDDMPDGGAEHFAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQRKVRDPRANFDQSLRVLKHAKEVRPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTKRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYKAGKLNGRACFCLVQNFNVILLAIIRFFTFVISALILINSLS", "length": 383, "header": "tr|A0AAA9SI71-1|LIAS_BOVIN Computationally mapped isoform of Lipoyl synthase, mitochondrial OS=Bos taurus OX=9913 GN=LIAS PE=2 SV=1 CANONICAL=Q5BIP7-1" }, "locus": { "chromosome": "6", "start_pos": 58579504, "end_pos": 58570431, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114754.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114754.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082243.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082243.1" } ] } }, { "isoform_ac": "A0AAA9SPT8-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7/entry#A0AAA9SPT8-1", "sequence": { "sequence": "MSLRCGGAVRTVGPRVFGRYVFSPVREVSFLPDEKKEFLQSGPDLQEFISGNLADKSTWDEYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDANEPYNTAKAIAEWGLDYVVLTSVDRDDMPDGGAEHFAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQRKVRDPRANFDQSLRVLKHAKEVRPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTKRHLKVNFS", "length": 322, "header": "tr|A0AAA9SPT8-1|LIAS_BOVIN Computationally mapped isoform of Lipoyl synthase, mitochondrial OS=Bos taurus OX=9913 GN=LIAS PE=2 SV=1 CANONICAL=Q5BIP7-1" }, "locus": { "chromosome": "6", "start_pos": 58581107, "end_pos": 58569644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127331.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127331.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086007.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086007.1" } ] } }, { "isoform_ac": "A0AAA9SRH8-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7/entry#A0AAA9SRH8-1", "sequence": { "sequence": "MSLRCGGAVRTVGPRVFGRYVFSPVREVSFLPDEKKEFLQSGPDLQEFISGNLADKSTWDEYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDANEPYNTAKAIAEWGLDYVVLTSVDRDDMPDGGAEHFAKTVSYLKERKVRDPRANFDQSLRVLKHAKEVRPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTKRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYKAGEFFLKNLVAKRKTKAL", "length": 329, "header": "tr|A0AAA9SRH8-1|LIAS_BOVIN Computationally mapped isoform of Lipoyl synthase, mitochondrial OS=Bos taurus OX=9913 GN=LIAS PE=2 SV=1 CANONICAL=Q5BIP7-1" }, "locus": { "chromosome": "6", "start_pos": 58581145, "end_pos": 58569644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123633.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123633.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085582.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085582.1" } ] } }, { "isoform_ac": "A0AAA9TG25-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7/entry#A0AAA9TG25-1", "sequence": { "sequence": "MSLRCGGAVRTVGPRVFGRYVFSPVREVSFLPDEKKEFLQSGPDLQEFISGNLADKSTWDEYKGNLKRQKGERCVRKLDVPILESVGEVENMLPPQPQSWNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQRKVRDPRANFDQSLRVLKHAKEVRPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTKRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYKAGEFFLKNLVAKRKTKAL", "length": 269, "header": "tr|A0AAA9TG25-1|LIAS_BOVIN Computationally mapped isoform of Lipoyl synthase, mitochondrial OS=Bos taurus OX=9913 GN=LIAS PE=2 SV=1 CANONICAL=Q5BIP7-1" }, "locus": { "chromosome": "6", "start_pos": 58581145, "end_pos": 58569644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133269.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133269.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095800.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095800.1" } ] } }, { "isoform_ac": "A0AAA9TLN4-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7/entry#A0AAA9TLN4-1", "sequence": { "sequence": "MSLRCGGAVRTVGPRVFGRYVFSPVREVSFLPDEKKEFLQSGPDLQEFISGNLADKSTWDEYKGNLKRQKGERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQRKVRDPRANFDQSLRVLKHAKEVRPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTKRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYKAGEFFLKNLVAKRKTKAL", "length": 242, "header": "tr|A0AAA9TLN4-1|LIAS_BOVIN Computationally mapped isoform of Lipoyl synthase, mitochondrial OS=Bos taurus OX=9913 GN=LIAS PE=2 SV=1 CANONICAL=Q5BIP7-1" }, "locus": { "chromosome": "6", "start_pos": 58581145, "end_pos": 58569644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105909.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105909.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098130.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098130.1" } ] } }, { "isoform_ac": "Q5BIP7-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7/entry#Q5BIP7-1", "sequence": { "sequence": "MSLRCGGAVRTVGPRVFGRYVFSPVREVSFLPDEKKEFLQSGPDLQEFISGNLADKSTWDEYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDANEPYNTAKAIAEWGLDYVVLTSVDRDDMPDGGAEHFAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQRKVRDPRANFDQSLRVLKHAKEVRPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTKRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYKAGEFFLKNLVAKRKTKAL", "length": 372, "header": "sp|Q5BIP7-1|LIAS_BOVIN Isoform 1 of Lipoyl synthase, mitochondrial OS=Bos taurus OX=9913 GN=LIAS PE=2 SV=1 CANONICAL=Q5BIP7-1" }, "locus": { "chromosome": "6", "start_pos": 58581145, "end_pos": 58569644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019299.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019299.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019299.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019299.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP7", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:530865", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530865", "resource": "KEGG Pathway" }, { "id": "R-BTA-9857492", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9857492", "resource": "Reactome", "description": "Protein lipoylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YXK1-1", "protein_name": "Lipoyl synthase, mitochondrial", "gene_name": "LIAS", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSLLPGSCRGASATTARRLLLLLGPHARVSENHLCNQYGTSSSLREETKKILQTGPDLEDFVSGDLADKSVWADYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRSLNLHTNHRMARVGRDLKYHQAPTSLSQAGLPTSTLNTARARLPRAPSNLALNTSRDGASTASLGSLFQHLTTVLVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTAKNPPPLDPEEPYNTAKAIAEWGLDYVVLTSVDRDDMPDGGAEHFAKTVSHLKERNSKIVVECLTPDFRGDLNAVEKVALSGLDVYAHNVETVPELQRKVRDPRANFEQSVRVLKHAKAVQPRVISKTSLMLGLGETDEQVLATMKLLREAGVDCLTLGQYMQPTKRHLKVEEYVTPEKFKYWEKVGNDLGFHYTASGPLVRSSYKAGEFFLKNLVEKRKTKVI", "length": 454 }, "evidence": [ { "id": "Q5BIP7", "url": "https://omabrowser.org/oma/group/Q5BIP7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O43766-1", "protein_name": "Lipoyl synthase, mitochondrial", "gene_name": "LIAS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLRCGDAARTLGPRVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDYVVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYKAGEFFLKNLVAKRKTKDL", "length": 372 }, "evidence": [ { "id": "Q5BIP7", "url": "https://omabrowser.org/oma/group/Q5BIP7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P32875-1", "protein_name": "Lipoyl synthase, mitochondrial", "gene_name": "LIP5", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MYRRSVGVLFVGRNTRWISSTIRCGTSATRPIRSNALNTDSDNASVRVPVGNSTEVENATSQLTGTSGKRRKGNRKRITEFKDALNLGPSFADFVSGKASKMILDPLEKARQNTEEAKKLPRWLKVPIPKGTNYHKLKGDVKELGLSTVCEEARCPNIGECWGGKDKSKATATIMLLGDTCTRGCRFCSVKTNRTPSKPDPMEPENTAEAIKRWGLGYVVLTTVDRDDLVDGGANHLAETVRKIKQKAPNTLVETLSGDFRGDLKMVDIMAQCGLDVYAHNLETVESLTPHVRDRRATYRQSLSVLERAKATVPSLITKTSIMLGLGETDEQITQTLKDLRNIQCDVVTFGQYMRPTKRHMKVVEYVKPEKFDYWKERALEMGFLYCASGPLVRSSYKAGEAFIENVLKKRNMK", "length": 414 }, "evidence": [ { "id": "Q5BIP7", "url": "https://omabrowser.org/oma/group/Q5BIP7/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q5XIH4-1", "protein_name": "Lipoyl synthase, mitochondrial", "gene_name": "Lias", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALRCWDAARSLGSRIFGRYACSVRALSSLPDEKKKFLHNGPDLQDFVSGDLADKSTWDDYKGNLKRQKGERLRLPPWLKTKIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDPSEPDNTARAIAEWGLDYVVLTSVDRDDVVDGGAEHIAKTVSCLKERNPKILVECLTPDFRGDLRAVEKVALSGLDVYAHNVETVPELQRKVRDPRANFDQSLRVLKHAKEVQPDVVSKTSIMLGLGETDEQVYATMKALRAADVDCLTLGQYMQPTKRHLKVEEYVTPEKFKYWEEVGNELGFHYTASGPLVRSSYKAGEFFLKNLVAKRKTKVSKV", "length": 373 }, "evidence": [ { "id": "Q5BIP7", "url": "https://omabrowser.org/oma/group/Q5BIP7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7JQW6-1", "protein_name": "Lipoyl synthase, mitochondrial", "gene_name": "Las", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLRALKTHAEAPIVVATRAASTNAEKLEEIRERLAKGPNFHDFVQNPDNTRNEWEQYDGKLRREKGEEQRLRLPPWLKTTIPVGKNYAKIKAQMRELKLSTVCEEARCPNIGECWGGGEHGTQTATIMLMGDTCTRGCRFCSVKTARKPPPLDVNEPVNTATAIASWGLDYIVLTSVDRDDLPDGGSEHIAETVREIKARNSNIFVECLVPDFRGNLECVKTIANSGLDVYAHNIETVEKLTPYVRDRRAHYRQTLQVLTEAKRFNPNLITKSSIMLGLGETDEEIENTLKDLREAGVDCVTLGQYMQPTNKHLKVIEYVTPEKFKHWEERGNELGFLYTASGPLVRSSYKAGEFFITSILENRKKRQNDTEVPKKQ", "length": 377 }, "evidence": [ { "id": "Q5BIP7", "url": "https://omabrowser.org/oma/group/Q5BIP7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q99M04-1", "protein_name": "Lipoyl synthase, mitochondrial", "gene_name": "Lias", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALRCWDTARSLGSRIFGRYAFTVRALSSLPDKKKEFLHNGPDLQDFVSGDLADKSTWDEYKGNLKRQKGERLRLPPWLKTKIPMGKNYNKLKNTLRNLSLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDANEPDNTAKAIAEWGLDYVVLTSVDRDDVADGGAEHIAKTVSCLKERNPKILVECLTPDFRGDLRAVEKVALSGLDVYAHNVETVPELQRKVRDPRANFDQSLRVLRHAKEVQPDVVSKTSIMLGLGETDEQVYATLKALRAADVDCLTLGQYMQPTKRHLKVEEYVTPEKFKYWEKVGNELGFLYTASGPLVRSSYKAGEFFLKNLVARRKTKASKV", "length": 373 }, "evidence": [ { "id": "Q5BIP7", "url": "https://omabrowser.org/oma/group/Q5BIP7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9ZWT1-1", "protein_name": "Lipoyl synthase, mitochondrial", "gene_name": "LIP1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MHSRSALLYRFLRPASRCFSSSSAVTPVTVTQSPKSLEALRARLANESPSLTDFIHGDTYSVEVGTKKKPLPKPKWMKESIPGGERYVQIKKKLRDLKLHTVCEEAKCPNLGECWSGGETGTATATIMILGDTCTRGCRFCNVKTSRTPPPPDPNEPNNVAEAIASWGVDYVVITSVDRDDLPDQGSGHFAETVQRLKFLKPEMLIEALVPDFRGDGGCVEKVSKSGLDVLAHNIETVEELQSFVRDHRANFKQSLDVLRMAKEYAPAGTLTKTSVMLGCGETPDQVVKTMEKVRAAGVDVMTFGQYMRPSKRHMPVAEYVTPDAFERYRLLGMEMGFRYVASGPMVRSSYKAGEYYIKSMIEADRVASPSTSP", "length": 374 }, "evidence": [ { "id": "Q5BIP7", "url": "https://omabrowser.org/oma/group/Q5BIP7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP7", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP7", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7" } ], "pmid": "" }, { "name": "4 iron, 4 sulfur cluster binding", "id": "GO:0051539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051539", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP7", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7" } ], "pmid": "" }, { "name": "lipoate synthase activity", "id": "GO:0016992", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016992", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP7", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein lipoylation", "id": "GO:0009249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009249", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP7", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7" } ], "pmid": "" }, { "name": "lipoate biosynthetic process", "id": "GO:0009107", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009107", "evidence": [ { "database": "UniProtKB", "id": "Q5BIP7", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16585", "name": "", "equation": "[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5BIP7-1" ], "evidence": [ { "id": "16585", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16585" } ] }, { "id": "R-BTA-6793591", "name": "LIAS synthesizes lipoyl-GCSH", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-2162265", "R-BTA-6793586" ], "output_participant_list": [ "R-ALL-1655881", "R-ALL-379705", "R-ALL-9857621", "R-ALL-6793613" ], "enzyme_list": [ "Q5BIP7-1" ], "evidence": [ { "id": "R-BTA-6793591", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6793591" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1655881", "participant_name": "H2S [mitochondrial matrix]", "crossref": [ { "id": "29919", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-2162265", "participant_name": "AdoMet [mitochondrial matrix]", "crossref": [ { "id": "8145813", "database": "PubChem Substance", "url": "" }, { "id": "ZINC000004214738", "database": "ZINC", "url": "" }, { "id": "ZINC000004228231", "database": "ZINC", "url": "" }, { "id": "59789", "database": "ChEBI", "url": "" }, { "id": "C00019", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-379705", "participant_name": "L-Met [mitochondrial matrix]", "crossref": [ { "id": "57844", "database": "ChEBI", "url": "" }, { "id": "ZINC000001532529", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-6793613", "participant_name": "5dAde [mitochondrial matrix]", "crossref": [ { "id": "ZINC000001999286", "database": "ZINC", "url": "" }, { "id": "17319", "database": "ChEBI", "url": "" }, { "id": "HMDB0001983", "database": "HMDB Metabolite", "url": "" }, { "id": "C05198", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-9857621", "participant_name": "Fe3+ [mitochondrial matrix]", "crossref": [ { "id": "C14819", "database": "COMPOUND", "url": "" }, { "id": "HMDB0015531", "database": "HMDB Metabolite", "url": "" }, { "id": "29034", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-BTA-6793586", "participant_name": "GCSH [mitochondrial matrix]", "crossref": [ { "id": "P20821", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000006795", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000008936", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000008936", "database": "ENSEMBL", "url": "" }, { "id": "3KLR", "database": "PDB", "url": "" }, { "id": "3WDN", "database": "PDB", "url": "" }, { "id": "NP_777269.1", "database": "RefSeq", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q5BIP7", "gene_name": "LIAS", "activity": [ { "ec_number": "2.8.1.8", "activity": "[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin].", "evidence": [ { "id": "Q5BIP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7" } ] }, { "ec_number": "2.8.1.8", "activity": "", "evidence": [ { "id": "Q5BIP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5BIP7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 372, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5BIP7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5BIP7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5BIP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP7" }, { "id": "PRU01266", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01266" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Radical SAM core", "eco_id": "ECO_0000255", "start_pos": 122, "end_pos": 341, "start_aa": "Glu", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.8.1.8", "ec_name": "[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin].", "evidence": [ { "id": "2.8.1.8", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.8" }, { "id": "2.8.1.8", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.8.1.8" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E975-1", "uniprot_ac": "Q5E975", "uniprot_id": "TM230_BOVIN", "mass": { "chemical_mass": 13158.0, "monoisotopic_mass": 13158.0 }, "refseq": { "ac": "NP_001014930", "name": "transmembrane protein 230", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014930" }, "gene_names": [ { "name": "TMEM230", "type": "recommended", "evidence": [ { "id": "Q5E975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E975" } ] }, { "name": "C13H20orf30", "type": "synonym", "evidence": [ { "id": "NP_001014930", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014930" } ] }, { "name": "C20orf30", "type": "synonym", "evidence": [ { "id": "NP_001014930", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014930" } ] }, { "name": "TMEM230", "type": "synonym", "evidence": [ { "id": "NP_001014930", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014930" } ] } ], "protein_names": [ { "name": "Transmembrane protein 230", "type": "recommended", "evidence": [ { "id": "Q5E975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E975/entry#names_and_taxonomy" } ] }, { "name": "UPF0414 transmembrane protein C20orf30 homolog", "type": "synonym", "evidence": [ { "id": "NP_001014930", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014930" } ] }, { "name": "transmembrane protein 230", "type": "synonym", "evidence": [ { "id": "NP_001014930", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014930" } ] } ], "function": [ { "annotation": "Involved in trafficking and recycling of synaptic vesicles.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAI7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI7#function" }, { "database": "UniProtKB", "id": "ARBA00024003", "url": 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CANONICAL=Q5E975-1" }, "locus": { "chromosome": "13", "start_pos": 47427273, "end_pos": 47422335, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090401.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090401.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083101.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083101.1" } ] } }, { "isoform_ac": "Q5E975-1", "url": "https://www.uniprot.org/uniprotkb/Q5E975/entry#Q5E975-1", "sequence": { "sequence": "MMPSRTNLATGIPSSKVKYSRLSSTDDGYIDLQFKKSPPKIPYKAIALATVLFLIGAFLIIIGSLLLAGYISKGGADRAVPVLIIGILVFLPGFYHLRIAYYASKGYRGYSYDDIPDFDD", "length": 120, "header": "sp|Q5E975-1|TM230_BOVIN Isoform 1 of Transmembrane protein 230 OS=Bos taurus OX=9913 GN=TMEM230 PE=2 SV=1 CANONICAL=Q5E975-1" }, "locus": { "chromosome": "13", "start_pos": 47427349, "end_pos": 47422335, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007965.3", "url": 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"UPK3B_BOVIN", "mass": { "chemical_mass": 30587.0, "monoisotopic_mass": 30587.0 }, "refseq": { "ac": "NP_001012690", "name": "uroplakin-3b precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012690" }, "gene_names": [ { "name": "UPK3B", "type": "recommended", "evidence": [ { "id": "Q864V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q864V4" } ] }, { "name": "UPK3B", "type": "synonym", "evidence": [ { "id": "NP_001012690", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012690" } ] } ], "protein_names": [ { "name": "Uroplakin-3b", "type": "recommended", "evidence": [ { "id": "Q864V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q864V4/entry#names_and_taxonomy" } ] }, { "name": "UP3b", "type": "synonym", "evidence": [ { "id": "NP_001012690", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012690" }, { "id": "Q864V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q864V4/entry#names_and_taxonomy" } ] }, { "name": "UPIIIb", "type": "synonym", "evidence": [ { "id": "NP_001012690", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012690" }, { "id": "Q864V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q864V4/entry#names_and_taxonomy" } ] }, { "name": "Uroplakin IIIb", "type": "synonym", "evidence": [ { "id": "Q864V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q864V4/entry#names_and_taxonomy" } ] }, { "name": "p35", "type": "synonym", "evidence": [ { "id": "NP_001012690", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012690" }, { "id": "Q864V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q864V4/entry#names_and_taxonomy" } ] }, { "name": "uroplakin IIIB", "type": "synonym", "evidence": [ { "id": "NP_001012690", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012690" } ] }, { "name": "uroplakin-3b precursor", "type": "synonym", "evidence": [ { "id": "NP_001012690", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012690" } ] }, { "name": "uroplakin-3b", "type": "synonym", "evidence": [ { "id": "NP_001012690", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012690" } ] } ], "function": [ { "annotation": "Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q864V4", "url": "https://www.uniprot.org/uniprotkb/Q864V4#function" } ] }, { "annotation": "These results indicate that p35 (uroplakin IIIb) is a urothelial differentiation product structurally and functionally related to uroplakin III, and that p35-UPIb interaction in the ER is an important early step in urothelial plaque assembly.", "evidence": [ { "database": "RefSeq", "id": "NP_001012690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012690" }, { "database": "PubMed", "id": "12446744", "url": "https://glygen.org/publication/PubMed/12446744" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q864V4", "url": "https://www.uniprot.org/uniprotkb/Q864V4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UPK3B", "url": "https://www.uniprot.org/uniprotkb/Q864V4", "locus": { "chromosome": "25", "start_pos": 34509114, "end_pos": 34504084, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021430", "url": "https://www.ensembl.org/id/ENSBTAG00000021430" } ] } } ], "crossref": [ { "id": "Q864V4", "url": "https://alphafold.ebi.ac.uk/entry/Q864V4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021430", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021430", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09969", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09969", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282115", "url": "https://www.ncbi.nlm.nih.gov/gene/282115", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR024831", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024831", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282115", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282115", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HFSSLWW", "url": "https://omabrowser.org/oma/group/HFSSLWW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q864V4", "url": "https://www.orthodb.org/?gene=Q864V4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15446", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15446", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15446:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15446:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001012690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012690", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SGG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGG9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q864V4", "url": "https://www.uniprot.org/uniprotkb/Q864V4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q864V4-1", "url": "https://www.uniprot.org/uniprotkb/Q864V4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLPSRQPRLWLLLLVVLGWPQPCLTLDLIPYTPRITSWDLEGKVTATTFSLEQPRCVLDRHSSAADTVWLVVAFSNASRVFQNPQTLAEIPASPRLLTDGHYMTLPLTMDQLPCEDPADGSGRAPVLRVGNDAGCLADLHQPRYCNAPLPGPGPYRVKFLLTNSRGSPQAETRWSDLIALRQGKSPGSIDTWPGRRSGDMIIITSILSSLAGLLLLAFLAASSVRFSSLWWPEEAPEQLRIGSFMGKRYMTHHIPPSEAATLPVGCEPGLERFPSLSP", "length": 279, "header": "sp|Q864V4-1|UPK3B_BOVIN Isoform 1 of Uroplakin-3b OS=Bos taurus OX=9913 GN=UPK3B PE=1 SV=1 CANONICAL=Q864V4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGG9-1", "url": "https://www.uniprot.org/uniprotkb/Q864V4/entry#A0AAA9SGG9-1", "sequence": { "sequence": "MGLPSRQPRLWLLLLVVLGWPQPCLTLDLIPYTPRITSWDLEGKVTATTFSLEQPRCVLDRHSSAADTVWLVVAFSNASRVFQNPQTLAEIPASPRLLTDGHYMTLPLTMDQLPCEDPADGSGRAPVLRVGNDAGCLADLHQPRYCNAPLPGPGPYREVPRLHRHVARAAEWRHDHHHLHPVFSGRPLAPGLPGSLQRALLQPVVAGGGPGAAADRLLHGKALHDPPHPAQRGSYPAGGLRAWPGTLPQPQPLAWPTWLGLGQWGPGG", "length": 268, "header": "tr|A0AAA9SGG9-1|UPK3B_BOVIN Computationally mapped isoform of Uroplakin-3b OS=Bos taurus OX=9913 GN=UPK3B PE=1 SV=1 CANONICAL=Q864V4-1" }, "locus": { "chromosome": "25", "start_pos": 34507857, "end_pos": 34504229, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131182.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131182.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085264.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085264.1" } ] } }, { "isoform_ac": "Q864V4-1", "url": "https://www.uniprot.org/uniprotkb/Q864V4/entry#Q864V4-1", "sequence": { "sequence": "MGLPSRQPRLWLLLLVVLGWPQPCLTLDLIPYTPRITSWDLEGKVTATTFSLEQPRCVLDRHSSAADTVWLVVAFSNASRVFQNPQTLAEIPASPRLLTDGHYMTLPLTMDQLPCEDPADGSGRAPVLRVGNDAGCLADLHQPRYCNAPLPGPGPYRVKFLLTNSRGSPQAETRWSDLIALRQGKSPGSIDTWPGRRSGDMIIITSILSSLAGLLLLAFLAASSVRFSSLWWPEEAPEQLRIGSFMGKRYMTHHIPPSEAATLPVGCEPGLERFPSLSP", "length": 279, "header": "sp|Q864V4-1|UPK3B_BOVIN Isoform 1 of Uroplakin-3b OS=Bos taurus OX=9913 GN=UPK3B PE=1 SV=1 CANONICAL=Q864V4-1" }, "locus": { "chromosome": "25", "start_pos": 34507810, "end_pos": 34504229, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044381.2", "url": "https://www.ensembl.org/id/ENSBTAT00000044381.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041883.1", "url": "https://www.ensembl.org/id/ENSBTAP00000041883.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 77, "start_aa": "Asn", "end_pos": 77, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn77", "evidence": [ { "id": "Q864V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q864V4#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly.", "journal": "J. Cell Biol.", "date": "2002", "authors": "Deng FM, Liang FX, Tu L, Resing KA, Hu P, Supino M, Hu CC, Zhou G, Ding M, Kreibich G, Sun TT", "evidence": [ { "database": "UniProtKB", "id": "Q864V4", "url": "https://www.uniprot.org/uniprotkb/Q864V4" }, { "database": "RefSeq", "id": "NP_001012690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012690" } ], "reference": [ { "type": "PubMed", "id": "12446744", "url": "https://glygen.org/publication/PubMed/12446744" } ] } ], "pathway": [ { "id": "bta:282115", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282115", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZKW6-1", "protein_name": "Uroplakin 3B", "gene_name": "Upk3b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEFTRMRPHPWPLLLPVLMWLPQSLSLDLIPYTPQITARDLGGKVTATTFSLEQPRCVFDEHASSNDTIWLVVAFSNASRDFQNPQTAAKIPTFPQLLTDGHYMTLPLSLDQLPCEDLTGGSGGVQVLRVGNDFGCYQRPYCNAPLPSQGPYSVKFLVMDAGGPPKAETKWSNPIFLHQGKNPNAIDTWPGRRSGCMIVITSILPVLAGLLLLAFLAASTTRFSSLWWPEEAPEQLRIGSFMGKRYMTHHIPPSEAATLPVGCEPGLDPLPSLSP", "length": 275 }, "evidence": [ { "id": "Q864V4", "url": "https://omabrowser.org/oma/group/Q864V4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80YF6-1", "protein_name": "Uroplakin-3b", "gene_name": "Upk3b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVRTRWQPPLRALLLLVLVWLPQSLSLDLIAYVPQITAWDLEGKITATTFSLEQPRCVFDEHVSTKDTIWLVVAFSNASRDFQNPQTAAKIPTFPQLLTDGHYMTLPLSLDQLPCEDLTGGSGGAPVLRVGNDFGCYQRPYCNAPLPSQGPYSVKFLVMDAAGPPKAETKWSNPIYLHQGKNPNSIDTWPGRRSGCMIVITSILSALAGLLLLAFLAASTTRFSSLWWPEEAPEQLRIGSFMGKRYMTHHIPPSEAATLPVGCEPGLDPLPSLSP", "length": 275 }, "evidence": [ { "id": "Q864V4", "url": "https://omabrowser.org/oma/group/Q864V4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BT76-1", "protein_name": "Uroplakin-3b", "gene_name": "UPK3B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGLPWGQPHLGLQMLLLALNCLRPSLSLGEWGSWMDASSQTQGAGGPAGVIGPWAPAPLRLGEAAPGTPTPVSVAHLLSPVATELVPYTPQITAWDLEGKVTATTFSLEQPRCVFDGLASASDTVWLVVAFSNASRGFQNPETLADIPASPQLLTDGHYMTLPLSPDQLPCGDPMAGSGGAPVLRVGHDHGCHQQPFCNAPLPGPGPYREDPRIHRHLARAAKWQHDRHYLHPLFSGRPPTLGLLGSLYHALLQPVVAGGGPGAAADRLLHGQALHDPPHPTQRGRHTAGGLQAWPGPPPQPQPLAWPLCMGLGEMGRWE", "length": 320 }, "evidence": [ { "id": "Q864V4", "url": "https://omabrowser.org/oma/group/Q864V4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q864V4", "url": "https://www.uniprot.org/uniprotkb/Q864V4" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q864V4", "url": "https://www.uniprot.org/uniprotkb/Q864V4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q864V4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 279, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q864V4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q864V4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 77 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58CR4-1", "uniprot_ac": "Q58CR4", "uniprot_id": "DOLK_BOVIN", "mass": { "chemical_mass": 59190.0, "monoisotopic_mass": 59190.0 }, "refseq": { "ac": "NP_001030442", "name": "dolichol kinase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030442" }, "gene_names": [ { "name": "DOLK", "type": "recommended", "evidence": [ { "id": "Q58CR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CR4" } ] }, { "name": "DOLK", "type": "synonym", "evidence": [ { "id": "NP_001030442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030442" } ] }, { "name": "TMEM15", "type": "synonym", "evidence": [ { "id": "NP_001030442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030442" }, { "id": "Q58CR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CR4" } ] } ], "protein_names": [ { "name": "Dolichol kinase", "type": "recommended", "evidence": [ { "id": "Q58CR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CR4/entry#names_and_taxonomy" } ] }, { "name": "2.7.1.108", "type": "synonym", "evidence": [ { "id": "Q58CR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CR4/entry#names_and_taxonomy" } ] }, { "name": "Transmembrane protein 15", "type": "synonym", "evidence": [ { "id": "Q58CR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CR4/entry#names_and_taxonomy" } ] }, { "name": "dolichol kinase", "type": "synonym", "evidence": [ { "id": "NP_001030442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030442" } ] }, { "name": "transmembrane protein 15", "type": "synonym", "evidence": [ { "id": "NP_001030442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030442" } ] } ], "function": [ { "annotation": "Catalyzes CTP-mediated phosphorylation of dolichol, the terminal step in de novo dolichyl monophosphate (Dol-P) biosynthesis. Dol-P is a lipid carrier essential for the synthesis of N-linked and O-linked oligosaccharides and for GPI anchors.", "evidence": [ { "database": "UniProtKB", "id": "Q58CR4", "url": "https://www.uniprot.org/uniprotkb/Q58CR4#function" }, { "database": "UniProtKB", "id": "Q9UPQ8", "url": "https://www.uniprot.org/uniprotkb/Q9UPQ8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CR4", "url": "https://www.uniprot.org/uniprotkb/Q58CR4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DOLK", "url": "https://www.uniprot.org/uniprotkb/Q58CR4", "locus": { "chromosome": "11", "start_pos": 99441038, "end_pos": 99446955, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010601", "url": "https://www.ensembl.org/id/ENSBTAG00000010601" } ] } } ], "crossref": [ { "id": "Q58CR4", "url": "https://alphafold.ebi.ac.uk/entry/Q58CR4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010601", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010601", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "526844", "url": "https://www.ncbi.nlm.nih.gov/gene/526844", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526844", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526844", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EIHWPGT", "url": "https://omabrowser.org/oma/group/EIHWPGT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58CR4", "url": "https://www.orthodb.org/?gene=Q58CR4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13205", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13205", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13205:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13205:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF28421", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28421", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-446199", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-446199", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030442", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13133", "url": "https://www.rhea-db.org/rhea/13133", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SJU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJU4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJU4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW22-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CR4", "url": "https://www.uniprot.org/uniprotkb/Q58CR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CR4-1", "url": "https://www.uniprot.org/uniprotkb/Q58CR4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTRECAPPTPGSGAPLSGSVLAEAAVVFVVVLSIHAAVWDRYSWCAVALAVQAFYVQYKWDRLLQQGSAVFQFRMSANSGLLPASVVMPLLGLVMKERCQAAGNPYFERFGIVVAATGMAVALFSSVLALGITRPVPTNTCVISGLAGGVIIYIMKHSLSVGEVIEVLEALLIFVYLNMILLYLLPRCFTPGEALLVLGGISFMLNQLIKRSLTVVESQGDPLDFFLLVVVVGMVLMGIFFSTLFVFMDSGTWASSIFFHLMTCVLGLGVVLPWLHRLIRRNPLLWLFQFLFQTETRVYLLAYWCLLATVACLVVLYQNAKRSSSESKKHQAPTITRKYFHFIVVATYIPGIILDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSLLSLFLDERDSGPLILTHIYLLLGMSLPIWLVPRPCTQKGSLGGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALILIFDSGVDLNYSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA", "length": 538, "header": "sp|Q58CR4-1|DOLK_BOVIN Isoform 1 of Dolichol kinase OS=Bos taurus OX=9913 GN=DOLK PE=2 SV=1 CANONICAL=Q58CR4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJU4-1", "url": "https://www.uniprot.org/uniprotkb/Q58CR4/entry#A0AAA9SJU4-1", "sequence": { "sequence": "MTRECAPPTPGSGAPLSGSVLAEAAVVFVVVLSIHAAVWDRYSWCAVALAVQAFYVQYKWDRLLQQGSAVFQFRMSANSGLLPASVVMPLLGLVMKERCQAAGNPYFERFGIVVAATGMAVALFSSVLALGITRPVPTNTCVISGLAGGVIIYIMKHSLSVGEVIEVLEALLIFVYLNMILLYLLPRCFTPGEALLVLGGISFMLNQLIKRSLTVVESQGDPLDFFLLVVVVGMVLMGIFFSTLFVFMDSGTWASSIFFHLMTCVLGLGVVLPWLHRLIRRNPLLWLFQFLFQTETRVYLLAYWCLLATVACLVVLYQNAKRSSSESKKHQAPTITRKYFHFIVVATYIPGIILDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSLLSLFLDERDSGPLILTHIYLLLGMSLPIWLVPRALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALILIFDSGVDLNYSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA", "length": 526, "header": "tr|A0AAA9SJU4-1|DOLK_BOVIN Computationally mapped isoform of Dolichol kinase OS=Bos taurus OX=9913 GN=DOLK PE=2 SV=1 CANONICAL=Q58CR4-1" }, "locus": { "chromosome": "11", "start_pos": 99445412, "end_pos": 99443799, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096964.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096964.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086571.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086571.1" } ] } }, { "isoform_ac": "A0AAA9SW22-1", "url": "https://www.uniprot.org/uniprotkb/Q58CR4/entry#A0AAA9SW22-1", "sequence": { "sequence": "MWGRGQHGVAGREAAVVFVVVLSIHAAVWDRYSWCAVALAVQAFYVQYKWDRLLQQGSAVFQFRMSANSGLLPASVVMPLLGLVMKERCQAAGNPYFERFGIVVAATGMAVALFSSVLALGITRPVPTNTCVISGLAGGVIIYIMKHSLSVGEVIEVLEALLIFVYLNMILLYLLPRCFTPGEALLVLGGISFMLNQLIKRSLTVVESQGDPLDFFLLVVVVGMVLMGIFFSTLFVFMDSGTWASSIFFHLMTCVLGLGVVLPWLHRLIRRNPLLWLFQFLFQTETRVYLLAYWCLLATVACLVVLYQNAKRSSSESKKHQAPTITRKYFHFIVVATYIPGIILDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSLLSLFLDERDSGPLILTHIYLLLGMSLPIWLVPRPCTQKGSLGGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALILIFDSGVDLNYSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA", "length": 528, "header": "tr|A0AAA9SW22-1|DOLK_BOVIN Computationally mapped isoform of Dolichol kinase OS=Bos taurus OX=9913 GN=DOLK PE=2 SV=1 CANONICAL=Q58CR4-1" }, "locus": { "chromosome": "11", "start_pos": 99445729, "end_pos": 99443799, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129286.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129286.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088216.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088216.1" } ] } }, { "isoform_ac": "Q58CR4-1", "url": "https://www.uniprot.org/uniprotkb/Q58CR4/entry#Q58CR4-1", "sequence": { "sequence": "MTRECAPPTPGSGAPLSGSVLAEAAVVFVVVLSIHAAVWDRYSWCAVALAVQAFYVQYKWDRLLQQGSAVFQFRMSANSGLLPASVVMPLLGLVMKERCQAAGNPYFERFGIVVAATGMAVALFSSVLALGITRPVPTNTCVISGLAGGVIIYIMKHSLSVGEVIEVLEALLIFVYLNMILLYLLPRCFTPGEALLVLGGISFMLNQLIKRSLTVVESQGDPLDFFLLVVVVGMVLMGIFFSTLFVFMDSGTWASSIFFHLMTCVLGLGVVLPWLHRLIRRNPLLWLFQFLFQTETRVYLLAYWCLLATVACLVVLYQNAKRSSSESKKHQAPTITRKYFHFIVVATYIPGIILDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSLLSLFLDERDSGPLILTHIYLLLGMSLPIWLVPRPCTQKGSLGGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALILIFDSGVDLNYSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA", "length": 538, "header": "sp|Q58CR4-1|DOLK_BOVIN Isoform 1 of Dolichol kinase OS=Bos taurus OX=9913 GN=DOLK PE=2 SV=1 CANONICAL=Q58CR4-1" }, "locus": { "chromosome": "11", "start_pos": 99445412, "end_pos": 99443799, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101751.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101751.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096537.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096537.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 9, "start_aa": "Thr", "end_pos": 9, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr9", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CR4", "url": "https://www.uniprot.org/uniprotkb/Q58CR4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:526844", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526844", "resource": "KEGG Pathway" }, { "id": "R-BTA-446199", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-446199", "resource": "Reactome", "description": "Synthesis of dolichyl-phosphate" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1TP87-1", "protein_name": "dolichol kinase", "gene_name": "DOLK", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTRECAPPASGSGAPLSGSVLAEAAVVFIVVLSIHAAVWDRYSWCAVALAVQAFYVQYKWDRLLQQGSAVFQFRMSANSGLLPASVVMPLLGLVMKERCQAAGNPYFERFGIVVAATGMAVALFSSVLALGITRPVPTNTCVISGLAGGVIIYIMKHSLSVGEVIEVLEVLLIFVYLNMILLYLLPRCFTPGEALLVLGGISFMLNQLIKRSLTVVESQGDPLDFFLLVVVVGMVLMGIFFSTLFVFMDSGTWASSIFFHLMTCVLGLGVVLPWLHRLIRRNPLLWLFQFLFQTETRVYLLAYWSLLATLACLVVLYQNAKRSSSESKKHQAPTIARKYFHFIVVATYIPGIIFDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSLLSLFLDERDSGPLILTHIYLLLGMSLPIWLVPRPCTQKGSLGGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALILIFDSGVDLNYSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA", "length": 538 }, "evidence": [ { "id": "Q58CR4", "url": "https://omabrowser.org/oma/group/Q58CR4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZLM6-1", "protein_name": "dolichol kinase", "gene_name": "Dolk", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTRQCPPQAPESGFALSGSVLAEAAVVFAVVLSIHAAVWDRYSWCAVALAVQAFYVQYKWDRLLQQGNAVFQFRMSANSGLLPASMVMPLLGLVMKERCLTAGNPYFERFGIVVAATGMAVALFSSVLALGITRPVPTNTCAISGLAGGIIIYIMKHSLSVGEVIEVLEVLLIFVYLNMILLYLLPRCFTPGEALLVLGGISFVLNQLIKRSLTESQGDPVDFFLLVVVVGMVLMGVFFSTLFVFMDSGTWASSIFFHLMTCVLGLGVVLPWLHWLIRRNPLLWLLQFLFYTETRIYLLAYWSLLATMACLVVLYQNAKRSSSESKKHKAPTITRKYFHFIVVATYIPGIIFDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSLLSLFLDERDSGPLILTHIYLLLGMSLPIWLIPRPCAQKGSLGGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALILIFDSGVDLNYSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA", "length": 536 }, "evidence": [ { "id": "Q58CR4", "url": "https://omabrowser.org/oma/group/Q58CR4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3IGZ1-1", "protein_name": "dolichol kinase", "gene_name": "Dolk", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTRQCPPPVAESGFPLSGSVLAEAAVVFAVVLSIHAAVWDRYSWCAVALAVQAFYVQYKWDRLLQQGNAVFQFRMSANSGLLPASMVMPLLGLVMKERCQTAGNPYFERFGVVVAATGMAVALFSSVLALGITRPVPTNTCAISGLAGGIIIYIMKHSLSVGEVIEVLEVLLVFVYLNMILLYLLPRCFTPGEALLVLGGISFVLNQLIKRSLTESQGDPVDFFLLVVVVGMVLMGVFFSTLFVFMDSGTWASSIFFHLMTCVLGLGVVLPWLHWLIRRNPLLWLLQFLFYTETRIYLLAYWSLLATMACLVVLYQNAKRSSSESKKHKAPAITRKYFHFIVVATYIPGIIFDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSLLSLFLDERDSGPLILTHIYLLLGMSLPIWLIPRPCTQKDSLGGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALILIFDSGVDLNYSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA", "length": 536 }, "evidence": [ { "id": "Q58CR4", "url": "https://omabrowser.org/oma/group/Q58CR4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8R2Y3-1", "protein_name": "Dolichol kinase", "gene_name": "Dolk", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTRQCPPQESGAALSGSVLAEAAVVFAVVLSIHAAVWDRYSWCAVALAVQAFYVQYKWDRLLQQGNAVFQFRMSANSGLLPASMVMPLLGLVMKERCQTAGNPYFERFGIVVAATGMAVALFSSVLALGITRPVPTNTCAISGLAGGVIIYIMRHSLSVGEVIEVLEVLLIFVYLNMILLYLLPRCFTPGEALLVLGGISFVLNQLIKRSLTESQGDPVDFFLLVVVVGMVLMGVFFSTLFVFMDSGTWASSIFFHLMTCVLGLGVVLPWLHWLIRRNPLLWLLQFLFYTETRIYLLAYWSLLASVACLVVLYQNAKRSSSESKKHRAPTITRKYFHFIVVATYIPGIIFDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSLLSLFLDERDSGPLILTHIYLLLGMSLPIWLIPRPCTQKDSLEGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALILIFDSGVDLNYSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA", "length": 534 }, "evidence": [ { "id": "Q58CR4", "url": "https://omabrowser.org/oma/group/Q58CR4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UPQ8-1", "protein_name": "Dolichol kinase", "gene_name": "DOLK", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTRECPSPAPGPGAPLSGSVLAEAAVVFAVVLSIHATVWDRYSWCAVALAVQAFYVQYKWDRLLQQGSAVFQFRMSANSGLLPASMVMPLLGLVMKERCQTAGNPFFERFGIVVAATGMAVALFSSVLALGITRPVPTNTCVILGLAGGVIIYIMKHSLSVGEVIEVLEVLLIFVYLNMILLYLLPRCFTPGEALLVLGGISFVLNQLIKRSLTLVESQGDPVDFFLLVVVVGMVLMGIFFSTLFVFMDSGTWASSIFFHLMTCVLSLGVVLPWLHRLIRRNPLLWLLQFLFQTDTRIYLLAYWSLLATLACLVVLYQNAKRSSSESKKHQAPTIARKYFHLIVVATYIPGIIFDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSFLSLFLDERDSGPLILTHIYLLLGMSLPIWLIPRPCTQKGSLGGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALILIFDSGVDLNYSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA", "length": 538 }, "evidence": [ { "id": "Q58CR4", "url": "https://omabrowser.org/oma/group/Q58CR4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "R4GI61-1", "protein_name": "dolichol kinase", "gene_name": "DOLK", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLNKPVLVESLIVFSIVLCVHAVVWDRYSWCAVALAIQAFYVQFKWDRLLQQGGAVFQFRTTANSGLLPASMVIPLLGIAMKERCKAAGIVYFERFGIVVASTGMLVALFLSVIAVGITKPVPTNTCILSGVAGSIIIYTMKHSLTVSEVIEVLEVLLIFVYLSMILLYLLPRCFTPGEALLVLGGISFVLNQLIKRSLNVIEGRGEPIDFFLLVAVIGVVILGLFFTVLFIFMDSGTWISSMFFHMMTAVLGLGVIMPWLYRLIRRNPLFWLLQFLFQTQTRVYLLIYWTLLAASACGIVFYQNAKRSSESKKHQASTITRKYFHFIVVATYVPGLIYDRQLLHVAAVLCLAVFIFLEYIRYFRIKPFGQTLRYLLSLFLDERDSGPLILTHIYLLLGMSLPVWLFPRSCAPKGALSGAGALVPYAGVLAVGVGDTMASVFGSTMGEIKWPGTKKTFEGTMTAIFAQIIAVALILIFDSSVNLNSSYAWILVSVSLVSLLEAYTTQIDNLLLPLYLQIMFMV", "length": 523 }, "evidence": [ { "id": "Q58CR4", "url": "https://omabrowser.org/oma/group/Q58CR4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q58CR4", "url": "https://www.uniprot.org/uniprotkb/Q58CR4" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q58CR4", "url": "https://www.uniprot.org/uniprotkb/Q58CR4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "dolichol kinase activity", "id": "GO:0004168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004168", "evidence": [ { "database": "UniProtKB", "id": "Q58CR4", "url": "https://www.uniprot.org/uniprotkb/Q58CR4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "dolichyl monophosphate biosynthetic process", "id": "GO:0043048", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043048", "evidence": [ { "database": "UniProtKB", "id": "Q58CR4", "url": "https://www.uniprot.org/uniprotkb/Q58CR4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 500, "end_pos": 502, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13133", "name": "", "equation": "a di-trans,poly-cis-dolichol + CTP = a di-trans,poly-cis-dolichyl phosphate + CDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q58CR4-1" ], "evidence": [ { "id": "13133", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13133" } ] }, { "id": "R-BTA-446195", "name": "DOLK phosphorylates DCHOL to DOLP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-110614", "R-ALL-449221" ], "output_participant_list": [ "R-ALL-110094" ], "enzyme_list": [ "Q58CR4-1" ], "evidence": [ { "id": "R-BTA-446195", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-446195" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-110094", "participant_name": "CDP [cytosol]", "crossref": [ { "id": "58069", "database": "ChEBI", "url": "" }, { "id": "C00112", "database": "COMPOUND", "url": "" }, { "id": "ZINC000008215624", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-110614", "participant_name": "CTP [cytosol]", "crossref": [ { "id": "37563", "database": "ChEBI", "url": "" }, { "id": "ZINC000003861746", "database": "ZINC", "url": "" }, { "id": "C00063", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-449221", "participant_name": "DCHOL [cytoplasmic side of endoplasmic reticulum membrane]", "crossref": [ { "id": "16091", "database": "ChEBI", "url": "" }, { "id": "C00381", "database": "COMPOUND", "url": "" }, { "id": "ZINC000030320742", "database": "ZINC", "url": "" }, { "id": "ZINC000030320745", "database": "ZINC", "url": "" }, { "id": "HMDB0005176", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q58CR4", "gene_name": "DOLK", "activity": [ { "ec_number": "2.7.1.108", "activity": "a di-trans,poly-cis-dolichol + CTP = a di-trans,poly-cis-dolichyl phosphate + CDP + H(+).", "evidence": [ { "id": "Q58CR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CR4" } ] }, { "ec_number": "2.7.1.108", "activity": "", "evidence": [ { "id": "Q58CR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CR4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CR4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 538, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CR4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CR4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.1.108", "ec_name": "a di-trans,poly-cis-dolichol + CTP = a di-trans,poly-cis-dolichyl phosphate + CDP + H(+).", "evidence": [ { "id": "2.7.1.108", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.108" }, { "id": "2.7.1.108", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.108" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 9 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 500, "end_pos": 502 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9J7-1", "uniprot_ac": "Q5E9J7", "uniprot_id": "ADAT2_BOVIN", "mass": { "chemical_mass": 21127.0, "monoisotopic_mass": 21127.0 }, "refseq": { "ac": "NP_001029952", "name": "tRNA-specific adenosine-34 deaminase catalytic subunit ADAT2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029952" }, "gene_names": [ { "name": "ADAT2", "type": "recommended", "evidence": [ { "id": "Q5E9J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7" } ] }, { "name": "DEADC1", "type": "recommended", "evidence": [ { "id": "Q5E9J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7" } ] }, { "name": "ADAT2", "type": "synonym", "evidence": [ { "id": "NP_001029952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029952" }, { "id": "Q5E9J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7" } ] }, { "name": "DEADC1", "type": "synonym", "evidence": [ { "id": "NP_001029952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029952" } ] } ], "protein_names": [ { "name": "tRNA-specific adenosine-34 deaminase catalytic subunit ADAT2", "type": "recommended", "evidence": [ { "id": "Q5E9J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7/entry#names_and_taxonomy" } ] }, { "name": "3.5.4.33", "type": "synonym", "evidence": [ { "id": "Q5E9J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7/entry#names_and_taxonomy" } ] }, { "name": "Deaminase domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "Q5E9J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7/entry#names_and_taxonomy" } ] }, { "name": "adenosine deaminase, tRNA-specific 2, TAD2 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029952" } ] }, { "name": "deaminase domain containing 1", "type": "synonym", "evidence": [ { "id": "NP_001029952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029952" } ] }, { "name": "deaminase domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001029952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029952" } ] }, { "name": "tRNA-specific adenosine deaminase 2", "type": "synonym", "evidence": [ { "id": "NP_001029952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029952" } ] }, { "name": "tRNA-specific adenosine-34 deaminase catalytic subunit ADAT2", "type": "synonym", "evidence": [ { "id": "NP_001029952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029952" } ] }, { "name": "tRNA-specific adenosine-34 deaminase subunit ADAT2", "type": "synonym", "evidence": [ { "id": "NP_001029952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029952" } ] } ], "function": [ { "annotation": "Catalytic subunit of the tRNA-specific adenosine-34 deaminase complex, composed of the ADAT2 catalytic subunit and the ADAT3 regulatory subunit, which deaminates adenosine-34 (the first, also called wobble position of the anticodon) to inosine in many tRNAs. Inosine-34 allows the decoding of 3 different nucleotides at the third position of mRNA codons, as inosine is able to pair with U, C, and A. Binding of the ADAT2-ADAT3 complex to tRNA is mediated by the N-terminus of ADAT3 which rotates with respect to the catalytic domain of the complex, formed by ADAT2 and the ADAT3 C-terminal domain, to position the tRNA anticodon stem-loop correctly in the ADAT2 active site. The ADAT2-ADAT3 complex is required for radial migration of projection neurons in the developing brain cortex, and the catalytic activity of the complex is necessary for this function.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J7", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7#function" }, { "database": "UniProtKB", "id": "Q6P6J0", "url": "https://www.uniprot.org/uniprotkb/Q6P6J0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9J7", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DEADC1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7", "locus": {} } ], "crossref": [ { "id": "Q5E9J7", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9J7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000026519", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026519", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01285", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01285", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615418", "url": "https://www.ncbi.nlm.nih.gov/gene/615418", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002125", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002125", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016192", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016192", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016193", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016193", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615418", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615418", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PCQMCAG", "url": "https://omabrowser.org/oma/group/PCQMCAG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9J7", "url": "https://www.orthodb.org/?gene=Q5E9J7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11079", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11079", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11079:SF149", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11079:SF149", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00383", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00383", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029952", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "43168", "url": "https://www.rhea-db.org/rhea/43168", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SK62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK62-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK62-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9J7", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9J7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAKAGPTAATDGAYSVSAEETEKWMEQAMQMAKDALDNTEVPVGCLMVYNNEVVGKGRNEVNQTKNATRHAEMVAIDQALDWCRRRGRSPSEVFEHTVLYVTVEPCIMCAAALRLMRIPLVVYGCQNERFGGCGSVLDIASADLPSTGKPFQCTPGYRAEEAVEMLKTFYKQENPNAPKSKVRKKECHKS", "length": 191, "header": "sp|Q5E9J7-1|ADAT2_BOVIN Isoform 1 of tRNA-specific adenosine-34 deaminase catalytic subunit ADAT2 OS=Bos taurus OX=9913 GN=DEADC1 PE=2 SV=1 CANONICAL=Q5E9J7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SK62-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7/entry#A0AAA9SK62-1", "sequence": { "sequence": "MEAKAGPTAATDGAYSVSAEETEKWMEQAMQMAKDALDNTEVPVGCLMVYNNEVVGKGRNEVNQTKNGSHLPLASMAPWPLCQHFPQATRHAEMVAIDQALDWCRRRGRSPSEVFEHTVLYVTVEPCIMCAAALRLMRIPLVVYGCQNERFGGCGSVLDIASADLPSTGKPFQCTPGYRAEEAVEMLKTFYKQENPNAPKSKVRKKECHKS", "length": 211, "header": "tr|A0AAA9SK62-1|ADAT2_BOVIN Computationally mapped isoform of tRNA-specific adenosine-34 deaminase catalytic subunit ADAT2 OS=Bos taurus OX=9913 GN=DEADC1 PE=2 SV=1 CANONICAL=Q5E9J7-1" }, "locus": { "chromosome": "9", "start_pos": 80913035, "end_pos": 80887273, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116169.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116169.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084309.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084309.1" } ] } }, { "isoform_ac": "Q5E9J7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7/entry#Q5E9J7-1", "sequence": { "sequence": "MEAKAGPTAATDGAYSVSAEETEKWMEQAMQMAKDALDNTEVPVGCLMVYNNEVVGKGRNEVNQTKNATRHAEMVAIDQALDWCRRRGRSPSEVFEHTVLYVTVEPCIMCAAALRLMRIPLVVYGCQNERFGGCGSVLDIASADLPSTGKPFQCTPGYRAEEAVEMLKTFYKQENPNAPKSKVRKKECHKS", "length": 191, "header": "sp|Q5E9J7-1|ADAT2_BOVIN Isoform 1 of tRNA-specific adenosine-34 deaminase catalytic subunit ADAT2 OS=Bos taurus OX=9913 GN=DEADC1 PE=2 SV=1 CANONICAL=Q5E9J7-1" }, "locus": { "chromosome": "9", "start_pos": 80913035, "end_pos": 80887273, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037717.4", "url": "https://www.ensembl.org/id/ENSBTAT00000037717.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037541.2", "url": "https://www.ensembl.org/id/ENSBTAP00000037541.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 8, "start_aa": "Thr", "end_pos": 8, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr8", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J7", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:615418", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615418", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287ATE6-1", "protein_name": "tRNA-specific adenosine-34 deaminase catalytic subunit ADAT2", "gene_name": "ADAT2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEAKGESTPAADGECSVSAEETEKWMEQAMQMAKEALENTEVPVGCLMVYNNEVVGKGRNEVNQTKNATRHAEMVAIDQVLDWCHRGGKSPSEVFERTVLYVTVEPCIMCAAALRLMKIPLVVYGCQNERFGGCGSVLDIASADLPNTGRPFQCIPGYRAEEAVEMLKTFYKQENPNAPKSKVRKKECQKS", "length": 191 }, "evidence": [ { "id": "Q5E9J7", "url": "https://omabrowser.org/oma/group/Q5E9J7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1P565-1", "protein_name": "tRNA-specific adenosine-34 deaminase catalytic subunit ADAT2", "gene_name": "ADAT2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEDEAAWMERAFSMAQEALEAGEVPVGCLLVYDGAAIGKGRNEVNETKNATRHAEMVAIDQVLEWCQQHKKDHEEVFSHSVLYVTVEPCIMCAAALRLMKIPRVVYGCRNERFGGCGSVLSISSDDIVDTGEPFECIAGYRAKDAVEMLKAFYRQENPNAPKSKVRKKDNRK", "length": 172 }, "evidence": [ { "id": "Q5E9J7", "url": "https://omabrowser.org/oma/group/Q5E9J7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P47058-1", "protein_name": "tRNA-specific adenosine-34 deaminase catalytic subunit TAD2", "gene_name": "TAD2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MQHIKHMRTAVRLARYALDHDETPVACIFVHTPTGQVMAYGMNDTNKSLTGVAHAEFMGIDQIKAMLGSRGVVDVFKDITLYVTVEPCIMCASALKQLDIGKVVFGCGNERFGGNGTVLSVNHDTCTLVPKNNSAAGYESIPGILRKEAIMLLRYFYVRQNERAPKPRSKSDRVLDKNTFPPMEWSKYLNEEAFIETFGDDYRTCFANKVDLSSNSVDWDLIDSHQDNIIQELEEQCKMFKFNVHKKSKV", "length": 250 }, "evidence": [ { "id": "Q5E9J7", "url": "https://omabrowser.org/oma/group/Q5E9J7/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q5RIV4-1", "protein_name": "tRNA-specific adenosine-34 deaminase catalytic subunit ADAT2", "gene_name": "adat2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MQEVGVDPEKNDFLQPSDSEVQTWMAKAFDMAVEALENGEVPVGCLMVYNNEIIGKGRNEVNETKNATRHAEMVALDQVLDWCRLREKDCKEVCEQTVLYVTVEPCIMCAAALRLLRIPFVVYGCKNERFGGCGSVLDVSSDHLPHTGTSFKCIAGYRAEEAVEMLKTFYKQENPNAPKPKVRKDSINPQDGAAVIQVMRGPPDEETETIAHLS", "length": 214 }, "evidence": [ { "id": "Q5E9J7", "url": "https://omabrowser.org/oma/group/Q5E9J7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6P6J0-1", "protein_name": "tRNA-specific adenosine-34 deaminase catalytic subunit ADAT2", "gene_name": "Adat2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEKVESTTTPDGPCVVSVQETEKWMEEAMRMAKEALENIEVPVGCLMVYNNEVVGKGRNEVNQTKNATRHAEMVAIDQVLDWCHQHGQSPSTVFEHTVLYVTVEPCIMCAAALRLMKIPLVVYGCQNERFGGCGSVLNIASADLPNTGRPFQCIPGYRAEEAVELLKTFYKQENPNAPKSKVRKKDCQKS", "length": 191 }, "evidence": [ { "id": "Q5E9J7", "url": "https://omabrowser.org/oma/group/Q5E9J7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7Z6V5-1", "protein_name": "tRNA-specific adenosine-34 deaminase catalytic subunit ADAT2", "gene_name": "ADAT2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEAKAAPKPAASGACSVSAEETEKWMEEAMHMAKEALENTEVPVGCLMVYNNEVVGKGRNEVNQTKNATRHAEMVAIDQVLDWCRQSGKSPSEVFEHTVLYVTVEPCIMCAAALRLMKIPLVVYGCQNERFGGCGSVLNIASADLPNTGRPFQCIPGYRAEEAVEMLKTFYKQENPNAPKSKVRKKECQKS", "length": 191 }, "evidence": [ { "id": "Q5E9J7", "url": "https://omabrowser.org/oma/group/Q5E9J7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VEM0-1", "protein_name": "CMP/dCMP-type deaminase domain-containing protein", "gene_name": "Dmel\\CG5292", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAAFMEEALVEARRARDAGEVPVGCVFVHGDKVVARGGNEVNVHRNATRHAEFICIDAILASCRERRLPARQLFSEITVVVTVEPCIMCSAALHTLGVKEIIYGCENDRFGGKTVVDVAAVVGHRIEITGGVRADEAMALLKDFYKGDNPAAPPQAKKKK", "length": 160 }, "evidence": [ { "id": "Q5E9J7", "url": "https://omabrowser.org/oma/group/Q5E9J7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J7", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J7", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J7", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7" } ], "pmid": "" }, { "name": "tRNA-specific adenosine-34 deaminase activity", "id": "GO:0052717", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052717", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J7", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "tRNA wobble adenosine to inosine editing", "id": "GO:0002100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002100", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J7", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" }, { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "43168", "name": "", "equation": "adenosine(34) in tRNA + H2O + H(+) = inosine(34) in tRNA + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9J7-1" ], "evidence": [ { "id": "43168", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43168" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q5E9J7", "gene_name": "DEADC1", "activity": [ { "ec_number": "3.5.4.33", "activity": "adenosine(34) in tRNA + H2O + H(+) = inosine(34) in tRNA + NH4(+).", "evidence": [ { "id": "Q5E9J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7" } ] }, { "ec_number": "3.5.4.33", "activity": "", "evidence": [ { "id": "Q5E9J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9J7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 191, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9J7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9J7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5E9J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7" }, { "id": "PRU01083", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01083" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CMP/dCMP-type deaminase", "eco_id": "ECO_0000255", "start_pos": 20, "end_pos": 145, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "Q5E9J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7#function" }, { "id": "Q5E9J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7" } ], "binding_site_uniprot": 107, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000250", "start_pos": 107, "end_pos": 107, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5E9J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7#function" }, { "id": "Q5E9J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7" } ], "binding_site_uniprot": 110, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000250", "start_pos": 110, "end_pos": 110, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5E9J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7#function" }, { "id": "Q5E9J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J7" } ], "binding_site_uniprot": 71, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000250", "start_pos": 71, "end_pos": 71, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.5.4.33", "ec_name": "adenosine(34) in tRNA + H2O + H(+) = inosine(34) in tRNA + NH4(+).", "evidence": [ { "id": "3.5.4.33", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.33" }, { "id": "3.5.4.33", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.5.4.33" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 8 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 63, "end_pos": 65 }, { "start_pos": 67, "end_pos": 69 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9U4-1", "uniprot_ac": "Q5E9U4", "uniprot_id": "TYW3_BOVIN", "mass": { "chemical_mass": 29303.0, "monoisotopic_mass": 29303.0 }, "refseq": { "ac": "NP_001015620", "name": "tRNA wybutosine-synthesizing protein 3 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015620" }, "gene_names": [ { "name": "TYW3", "type": "recommended", "evidence": [ { "id": "Q5E9U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4" } ] }, { "name": "TYW3", "type": "synonym", "evidence": [ { "id": "NP_001015620", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015620" } ] } ], "protein_names": [ { "name": "tRNA wybutosine-synthesizing protein 3 homolog", "type": "recommended", "evidence": [ { "id": "Q5E9U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.282", "type": "synonym", "evidence": [ { "id": "Q5E9U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4/entry#names_and_taxonomy" } ] }, { "name": "tRNA wybutosine-synthesizing protein 3 homolog", "type": "synonym", "evidence": [ { "id": "NP_001015620", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015620" } ] }, { "name": "tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))- methyltransferase", "type": "synonym", "evidence": [ { "id": "NP_001015620", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015620" } ] }, { "name": "tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase", "type": "synonym", "evidence": [ { "id": "Q5E9U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4/entry#names_and_taxonomy" } ] }, { "name": "tRNA-yW-synthesizing protein 3", "type": "synonym", "evidence": [ { "id": "NP_001015620", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015620" }, { "id": "Q5E9U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SKW2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKW2#function" }, { "database": "UniProtKB", "id": "ARBA00025378", "url": "https://www.uniprot.org/uniprotkb/ARBA00025378#function" } ] }, { "annotation": "S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of wybutosine, a hyper modified guanosine with a tricyclic base located at position 37 of eukaryotic phenylalanine tRNA (tRNA(Phe)) that contributes to maintenance of the translational reading frame. Catalyzes the methylation of 4-demethylwyosine, generating intermediates required for the formation of mature wybutosine.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U4", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4#function" }, { "database": "UniProtKB", "id": "P53177", "url": "https://www.uniprot.org/uniprotkb/P53177#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9U4", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TYW3", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4", "locus": { "chromosome": "3", "start_pos": 69968112, "end_pos": 69990582, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005196", "url": "https://www.ensembl.org/id/ENSBTAG00000005196" } ] } } ], "crossref": [ { "id": "Q5E9U4", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9U4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005196", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005196", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "519731", "url": "https://www.ncbi.nlm.nih.gov/gene/519731", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036602", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036602", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519731", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519731", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TWLYVSH", "url": "https://omabrowser.org/oma/group/TWLYVSH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9U4", "url": "https://www.orthodb.org/?gene=Q5E9U4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48418", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48418", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48418:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48418:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02676", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02676", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015620", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "36635", "url": "https://www.rhea-db.org/rhea/36635", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SKW2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKW2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKW2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9U4", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9U4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLSAEFKRWKAQCLSKADLSRKGSVDEDVLEIVQLLNGQEQFFTTSSCAGRIILLDRSVNGSEVQKQNCCWLLVTHKACVKDDVIVALQKAKGDAILKFEPLVLHVQCRQLQDAQILHSVAIDSGFRNSGITVGKRGKTMLAVRSTHGLEVPLSHQGKLMVTEEYINFLLKIANQKMEENKKRIERFYHCLQHALEKETVSTTSQPKEKVNTSYIRKKKRNPGKARGKRVNEEHDKELENNDHDDPGISDTIFPEDY", "length": 258, "header": "sp|Q5E9U4-1|TYW3_BOVIN Isoform 1 of tRNA wybutosine-synthesizing protein 3 homolog OS=Bos taurus OX=9913 GN=TYW3 PE=2 SV=1 CANONICAL=Q5E9U4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKW2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4/entry#A0AAA9SKW2-1", "sequence": { "sequence": "MDLSAEFKRWKAQCLSKADLSRKGSVDEDVLEIVQLLNGQEQFFTTSSCAGRIILLDRSVNGSEVQKQNCCWLLVTHKACVKDDVIIFVMGKIAASNPSRKRFTFKIHALFPKDSESSCLIVALQKAKGDAILKFEPLVLHVQCRQLQDAQILHSVAIDSGFRNSGITVGKRGKTMLAVRSTHGLEVPLSHQGKLMVTEEYINFLLKIANQKMEENKKRIERFYHCLQHALEKETVSTTSQPKEKVNTSYIRKKKRNPGKARGKRVNEEHDKELENNDHDDPGISDTIFPEDY", "length": 293, "header": "tr|A0AAA9SKW2-1|TYW3_BOVIN Computationally mapped isoform of tRNA wybutosine-synthesizing protein 3 homolog OS=Bos taurus OX=9913 GN=TYW3 PE=2 SV=1 CANONICAL=Q5E9U4-1" }, "locus": { "chromosome": "3", "start_pos": 69990544, "end_pos": 69968374, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119584.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119584.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084547.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084547.1" } ] } }, { "isoform_ac": "Q5E9U4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4/entry#Q5E9U4-1", "sequence": { "sequence": "MDLSAEFKRWKAQCLSKADLSRKGSVDEDVLEIVQLLNGQEQFFTTSSCAGRIILLDRSVNGSEVQKQNCCWLLVTHKACVKDDVIVALQKAKGDAILKFEPLVLHVQCRQLQDAQILHSVAIDSGFRNSGITVGKRGKTMLAVRSTHGLEVPLSHQGKLMVTEEYINFLLKIANQKMEENKKRIERFYHCLQHALEKETVSTTSQPKEKVNTSYIRKKKRNPGKARGKRVNEEHDKELENNDHDDPGISDTIFPEDY", "length": 258, "header": "sp|Q5E9U4-1|TYW3_BOVIN Isoform 1 of tRNA wybutosine-synthesizing protein 3 homolog OS=Bos taurus OX=9913 GN=TYW3 PE=2 SV=1 CANONICAL=Q5E9U4-1" }, "locus": { "chromosome": "3", "start_pos": 69990544, "end_pos": 69968374, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006849.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006849.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006849.4", "url": "https://www.ensembl.org/id/ENSBTAP00000006849.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 25, "end_pos": 25, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U4", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4" } ], "site_lbl": "Ser25" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U4", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:519731", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519731", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PIG9-1", "protein_name": "tRNA wybutosine-synthesizing protein 3 homolog", "gene_name": "TYW3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAFGRWKAQRLARADCSRRGALDERAAGVVRLLNGRAPFCTTSSCSGRLVLAEGGAAESAGVPAAIPKKRCRWLLVAHEPCGRADVMAALEKATGDVVFKFEPFVLHVLCQELQDAQLLHSVAIESGFKNSGITVGRGGKIMMAVRSAHCLEVPLSHMGKLMVSEEYIEFLVHVANQKMEENARRIDRFYKHLEAALEAAGGVSNSPSTDTQEVHAVYVRRRKRRTVQTQDVLPSPEGHNEELEPGDDPEGSLDIFAGITL", "length": 262 }, "evidence": [ { "id": "Q5E9U4", "url": "https://omabrowser.org/oma/group/Q5E9U4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P53177-1", "protein_name": "tRNA wybutosine-synthesizing protein 3", "gene_name": "TYW3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAAQNAFEQKKRAILNEIDSTQPDLSPKGTIDELCLPIIDLINASADMVTTSSCSGRVSVFLEGTKSYNGEVKIGGKGQGGKWLYVTHDREKVIGWLDELKSKSEFSFELSGKEIPTEKVTGSIRYILYKYEPFILHVKCRDFQAASKLYNTAMSCGFRESGIGSNNLVAIRINIKLDVPLGYLDETSGTLKFFVTPEYVSVLDSLSLSKFDENTRKMQALYDRIEKELINCAPDVNSKVNITPIETKEERRERKKREGMERQRQLKSPQNVL", "length": 273 }, "evidence": [ { "id": "Q5E9U4", "url": "https://omabrowser.org/oma/group/Q5E9U4/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q19QT9-1", "protein_name": "tRNA wybutosine-synthesizing protein 3 homolog", "gene_name": "TYW3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDRRAEFKRWKAQCLSKADFSRKGCVDEDVVEIVQLLNGREQFFTTSSCAGRIILLEQGMDSLEVQKQNCCWLLVSHKPCVKDDVIVALKKANGDAILKFEPLVLHVQCRQLQDAQILHSVAIDSGFRNSGITVGKRGKTMLAVRSTHGLEVPLSHKGKLMVTEEYIDFLLKIANHKMEENKKRIERFYNCLQLALEKETTTTNSHPKEKIKEKNNSYKKKSNPGKAHDKCVTEENDKVLENDDDDDPGISVTIFPEDY", "length": 259 }, "evidence": [ { "id": "Q5E9U4", "url": "https://omabrowser.org/oma/group/Q5E9U4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6DHJ1-1", "protein_name": "tRNA wybutosine-synthesizing protein 3 homolog", "gene_name": "tyw3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDGDSFQQWKNQCLNKCDFSKKGSVDEDISHVVSFINSQDRYFTTSSCSGRIILFDAVSDCPDVQKQNCSWLFVTHQKCQMEDVVRGLEKSVGDATFKFEPFVLHVQCKQLEDAQLLHTVAINSGFRNSGITVGKKGKIIMAVRSTHCLEVPLSHRSHVLVTHQYLDFLVGVANQKMEENLKRIQRFSECLQAALQPQEEKCSFKEADNKTVYRRRRKRTQDVSVTDSSQNTQEHHENTEEEIDCDLLFLL", "length": 251 }, "evidence": [ { "id": "Q5E9U4", "url": "https://omabrowser.org/oma/group/Q5E9U4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6IPR3-1", "protein_name": "tRNA wybutosine-synthesizing protein 3 homolog", "gene_name": "TYW3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDRSAEFRKWKAQCLSKADLSRKGSVDEDVVELVQFLNMRDQFFTTSSCAGRILLLDRGINGFEVQKQNCCWLLVTHKLCVKDDVIVALKKANGDATLKFEPFVLHVQCRQLQDAQILHSMAIDSGFRNSGITVGKRGKTMLAVRSTHGLEVPLSHKGKLMVTEEYIDFLLNVANQKMEENKKRIERFYNCLQHALERETMTNLHPKIKEKNNSSYIHKKKRNPEKTRAQCITKESDEELENDDDDDLGINVTIFPEDY", "length": 259 }, "evidence": [ { "id": "Q5E9U4", "url": "https://omabrowser.org/oma/group/Q5E9U4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BSA9-1", "protein_name": "tRNA wybutosine-synthesizing protein 3 homolog", "gene_name": "Tyw3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDRSAEFGRWKAQSLSKADLSRKGSVDEDAVEVVELLNSREEFFTTSSCAGRILLLDGSTEGSGVQKQHCCWLLVTHKPCARDDVMAALKGATSEAVLKFEPFILHVQCRTLQDAQTLHSVAIDSGFRNSGITVGKRGKTMLAVRGTHGLEVPLTHKGKLMVTEEYIEFLLTIANQKMEENKRRIGRFYNYLQHALKRETISNSHSKIKERNNPLCTHKNRRSQGKAQGPSTTEDNGRELEDGDGLEISAALFLGDD", "length": 257 }, "evidence": [ { "id": "Q5E9U4", "url": "https://omabrowser.org/oma/group/Q5E9U4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "tRNA methyltransferase activity", "id": "GO:0008175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008175", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U4", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4" } ], "pmid": "" }, { "name": "methyltransferase activity", "id": "GO:0008168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008168", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U4", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U4", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "tRNA methylation", "id": "GO:0030488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030488", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U4", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4" } ], "pmid": "" }, { "name": "wybutosine biosynthetic process", "id": "GO:0031591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031591", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U4", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4" } ], "pmid": "" }, { "name": "tRNA processing", "id": "GO:0008033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008033", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U4", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4" } ], "pmid": "" }, { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U4", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 212, "end_pos": 214, "annotation": "n_glycosylation_sequon" }, { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "36635", "name": "", "equation": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9U4-1" ], "evidence": [ { "id": "36635", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36635" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q5E9U4", "gene_name": "TYW3", "activity": [ { "ec_number": "2.1.1.282", "activity": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "Q5E9U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4" } ] }, { "ec_number": "2.1.1.282", "activity": "", "evidence": [ { "id": "Q5E9U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9U4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9U4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 258, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9U4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9U4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.1.1.282", "ec_name": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "2.1.1.282", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.282" }, { "id": "2.1.1.282", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.282" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 25 ], "sequon_annotation_sites": [ { "start_pos": 212, "end_pos": 214 }, { "start_pos": 61, "end_pos": 63 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBW2-1", "uniprot_ac": "Q3ZBW2", "uniprot_id": "HAOX2_BOVIN", "mass": { "chemical_mass": 39253.0, "monoisotopic_mass": 39253.0 }, "refseq": { "ac": "NP_001030243", "name": "2-Hydroxyacid oxidase 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030243" }, "gene_names": [ { "name": "HAO2", "type": "recommended", "evidence": [ { "id": "Q3ZBW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2" } ] }, { "name": "HAO2", "type": "synonym", "evidence": [ { "id": "NP_001030243", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030243" } ] }, { "name": "HAOX2", "type": "synonym", "evidence": [ { "id": "NP_001030243", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030243" } ] } ], "protein_names": [ { "name": "2-Hydroxyacid oxidase 2", "type": "recommended", "evidence": [ { "id": "Q3ZBW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2/entry#names_and_taxonomy" } ] }, { "name": "(S)-2-hydroxy-acid oxidase, peroxisomal", "type": "synonym", "evidence": [ { "id": "NP_001030243", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030243" }, { "id": "Q3ZBW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2/entry#names_and_taxonomy" } ] }, { "name": "(S)-hydroxy-acid oxidase, peroxisomal", "type": "synonym", "evidence": [ { "id": "NP_001030243", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030243" } ] }, { "name": "1.1.3.15", "type": "synonym", "evidence": [ { "id": "Q3ZBW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2/entry#names_and_taxonomy" } ] }, { "name": "2-Hydroxyacid oxidase 2", "type": "synonym", "evidence": [ { "id": "NP_001030243", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030243" } ] }, { "name": "HAOX2", "type": "synonym", "evidence": [ { "id": "Q3ZBW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2/entry#names_and_taxonomy" } ] }, { "name": "hydroxyacid oxidase 2 (long chain)", "type": "synonym", "evidence": [ { "id": "NP_001030243", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030243" } ] }, { "name": "long chain alpha-hydroxy acid oxidase", "type": "synonym", "evidence": [ { "id": "NP_001030243", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030243" } ] }, { "name": "long-chain L-2-hydroxy acid oxidase", "type": "synonym", "evidence": [ { "id": "NP_001030243", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030243" } ] } ], "function": [ { "annotation": "Oxidase that catalyzes the oxidation of medium and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, to the corresponding 2-oxoacids. Its role in the oxidation of 2-hydroxy fatty acids may contribute to the general pathway of fatty acid alpha-oxidation. Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2#function" }, { "database": "UniProtKB", "id": "Q9NYQ3", "url": "https://www.uniprot.org/uniprotkb/Q9NYQ3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HAO2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2", "locus": { "chromosome": "3", "start_pos": 23732791, "end_pos": 23763956, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000123", "url": "https://www.ensembl.org/id/ENSBTAG00000000123" } ] } } ], "crossref": [ { "id": "Q3ZBW2", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBW2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000123", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000123", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02809", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02809", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509481", "url": "https://www.ncbi.nlm.nih.gov/gene/509481", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000262", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000262", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012133", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012133", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509481", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509481", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WADFQYE", "url": "https://omabrowser.org/oma/group/WADFQYE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBW2", "url": "https://www.orthodb.org/?gene=Q3ZBW2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10578", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10578", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10578:SF149", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10578:SF149", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01070", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01070", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-390918", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390918", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9033241", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033241", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030243", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030243", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16789", "url": "https://www.rhea-db.org/rhea/16789", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67940", "url": "https://www.rhea-db.org/rhea/67940", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67944", "url": "https://www.rhea-db.org/rhea/67944", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SMK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBW2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBW2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLVCLTDFREHAREHLSKSTWDFIEGGADDCCTRDENMAAFKKIRLRPRYLKDVSKVDMRTTIQGAEISAPICIAPTGFHRLAWPDGEMSTARAAQAASICYITSTYASCSLEDIVAAAPRGLRWFQLYVHPNRQINKQMIQKVESLGFKALVITVDVPKVGNRRNDITNQVDLMKKLLLKDLGSPEMGNVMPYFQMSPIDPSICWEDLSWFQSMTRLPIILKGILTKEDAELAVKHNVHGIIVSNHGGRQLDEVPASIDALTEVVAAVKGKVEVYLDGGIRTGNDVLKALALGAKCVFVGRPILWGLAYKGEHGVKEVLDILKNEFHTSMTLTGCRSVAEINQDLIQFSRL", "length": 353, "header": "sp|Q3ZBW2-1|HAOX2_BOVIN Isoform 1 of 2-Hydroxyacid oxidase 2 OS=Bos taurus OX=9913 GN=HAO2 PE=2 SV=1 CANONICAL=Q3ZBW2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMK1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2/entry#A0AAA9SMK1-1", "sequence": { "sequence": "MPLVCLTDFREHAREHLSKSTWDFIEGGADDCCTRDENMAAFKKIRLRPRYLKDVSKVDMRTTIQGAEISAPICIAPTGFHRLAWPDGEMSTARAAQAASICYITSTYASCSLEDIVAAAPRGLRWFQLYVHPNRQINKQMIQKVESLGFKALVITVDVPKVGNRRNDITNQVDLMKKLLLKDLGSPEMGNVMPYFQMSPIDPSICWEDLSWFQSMTRLPIILKGILTKEDAELAVKHNVHGIIVSNHGGRQLDEVPASIDALTEVVAAVKGKVEVYLDGGIRTGNDVLKALALGAKCVFVGRPILWGLAYKGEHGVKEVLDILKNEFHTSMTLTGKQVSGINEVTIKQCS", "length": 351, "header": "tr|A0AAA9SMK1-1|HAOX2_BOVIN Computationally mapped isoform of 2-Hydroxyacid oxidase 2 OS=Bos taurus OX=9913 GN=HAO2 PE=2 SV=1 CANONICAL=Q3ZBW2-1" }, "locus": { "chromosome": "3", "start_pos": 23748968, "end_pos": 23737170, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135895.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135895.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085175.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085175.1" } ] } }, { "isoform_ac": "Q3ZBW2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2/entry#Q3ZBW2-1", "sequence": { "sequence": "MPLVCLTDFREHAREHLSKSTWDFIEGGADDCCTRDENMAAFKKIRLRPRYLKDVSKVDMRTTIQGAEISAPICIAPTGFHRLAWPDGEMSTARAAQAASICYITSTYASCSLEDIVAAAPRGLRWFQLYVHPNRQINKQMIQKVESLGFKALVITVDVPKVGNRRNDITNQVDLMKKLLLKDLGSPEMGNVMPYFQMSPIDPSICWEDLSWFQSMTRLPIILKGILTKEDAELAVKHNVHGIIVSNHGGRQLDEVPASIDALTEVVAAVKGKVEVYLDGGIRTGNDVLKALALGAKCVFVGRPILWGLAYKGEHGVKEVLDILKNEFHTSMTLTGCRSVAEINQDLIQFSRL", "length": 353, "header": "sp|Q3ZBW2-1|HAOX2_BOVIN Isoform 1 of 2-Hydroxyacid oxidase 2 OS=Bos taurus OX=9913 GN=HAO2 PE=2 SV=1 CANONICAL=Q3ZBW2-1" }, "locus": { "chromosome": "3", "start_pos": 23748968, "end_pos": 23734062, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000134.4", "url": "https://www.ensembl.org/id/ENSBTAT00000000134.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000134.3", "url": "https://www.ensembl.org/id/ENSBTAP00000000134.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:509481", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509481", "resource": "KEGG Pathway" }, { "id": "R-BTA-390918", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390918", "resource": "Reactome", "description": "Peroxisomal lipid metabolism" }, { "id": "R-BTA-9033241", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033241", "resource": "Reactome", "description": "Peroxisomal protein import" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BQZ1-1", "protein_name": "(S)-2-hydroxy-acid oxidase", "gene_name": "HAO2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPLVCLTDFQDHARERLSKSTWDFIEGGADACLTRDDNVAAFKKIRLRPRYLKDVSKVDTRITIQGEEISAPICIAPMGFHCLAWPDGEMSTARAARAAGICYVTSMYASCSLEDIVGTAPGGLRWFQLYVHPNRQLNKQLIQKVESLGFKALVITVDVPKIGNRRHNMANQVDLQKTLLLKDLGLSAKGNSMPYFQMSPIDPSICWDDLSWFQSLTRLPIILKGILTKEDAELAVKHNVHGIIVSNHGGRQLDEVPASIDALSEVVAAVKGKIEVYLDGGIRTGNDVLKALALGAKCVFVGRPILWGLACKGEHGVEEVLNILKNEFHTSMTLTGCRSVAEINRDLIQFSRL", "length": 353 }, "evidence": [ { "id": "Q3ZBW2", "url": "https://omabrowser.org/oma/group/Q3ZBW2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V1A097-1", "protein_name": "(S)-2-hydroxy-acid oxidase", "gene_name": "HAO2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVEGFPEHLCAMAMVCLLDFEAYAEKYLPKIAWDFFAAGADECSTRDENILAYKRIRFRPRMLRDVSMLDTRTKILGTEISFPVGIAPTGFHQLAWPDGEKSTARAAKAMGTCYIASTYSTCSLEEIAAAAPGGFRWFQLYIHRNRAVSRQLVQQAEALGFQGLVLTADLPYTGKRRNDVRNGFRLPPHMKLKNLEGAFEGDDRSEYGLPPNSLDPSVTWDDIYWLRSLTHLPIVIKGILTKEDAELAVRHGVQGIIVSNHGGRQLDGAPATIDALVEVVEAVRDRVEVYLDGGIRKGSDVLKALALGAKCVFIGRPALWGLAYKGEEGLQDVLRILRDEFRLSMALAGCASISEIGQDLVQFSKL", "length": 366 }, "evidence": [ { "id": "Q3ZBW2", "url": "https://omabrowser.org/oma/group/Q3ZBW2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0AC58GDQ2-1", "protein_name": "(S)-2-hydroxy-acid oxidase", "gene_name": "hao2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MERHKRMNLLGSSREEGVCAEMAMVCLDDFEEYAKQHLSKSTWDYYEAGADECCTRDDNLQAYKRIRLRPRILRDVSINDTRTSVLGREISFPVGIAPTAFHCLAWHEGELATARATEALNTCYIASTYATCSVEEIAAAAPNGYRWFQLYLYRDRKLSEQIVHRVEALGYKALVLTVDVPYTGKRRNDIRNQFKLPPHLKVKNFEGMFQEQTEAQEEYGIPANTLDPSISWKDVCWLQSLTRLPIIIKGILTKEDAELAVEHGVQGIIVSNHGGRQLDGGPATIDCLPEIVDTVQGRVEVYMDGGIRTGNDVLKAIALGARCVFIGRPAIWGLAYKGEDGVKEILNILHDEFRLSMVLAGCRNVAEINRNLIQFSRL", "length": 378 }, "evidence": [ { "id": "Q3ZBW2", "url": "https://omabrowser.org/oma/group/Q3ZBW2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q07523-1", "protein_name": "2-Hydroxyacid oxidase 2", "gene_name": "Hao2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPLVCLADFKAHAQKQLSKTSWDFIEGEADDGITYSENIAAFKRIRLRPRYLRDMSKVDTRTTIQGQEISAPICISPTAFHSIAWPDGEKSTARAAQEANICYVISSYASYSLEDIVAAAPEGFRWFQLYMKSDWDFNKQMVQRAEALGFKALVITIDTPVLGNRRRDKRNQLNLEANILLKDLRALKEEKPTQSVPVSFPKASFCWNDLSLLQSITRLPIILKGILTKEDAELAMKHNVQGIVVSNHGGRQLDEVSASIDALREVVAAVKGKIEVYMDGGVRTGTDVLKALALGARCIFLGRPILWGLACKGEDGVKEVLDILTAELHRCMTLSGCQSVAEISPDLIQFSRL", "length": 353 }, "evidence": [ { "id": "Q3ZBW2", "url": "https://omabrowser.org/oma/group/Q3ZBW2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NYQ2-1", "protein_name": "2-Hydroxyacid oxidase 2", "gene_name": "Hao2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLLCLADFKAQAQKQLSKTSWDFIEGEADDGITYNDNLAAFRRIRLRPRYLRDVSKIDTRTTIQGQEINAPICISPTAFHSIAWADGEKSTAKAAQKANICYVISSYASYTVEDIVAAAPGGLHWFQLYVQPDWDINKQMVQRIEALGFKALVVTVDAPVLGNRRGNKRSLLDLEANIKLKDLRSPGESKSGLPTPLSMPSSSSCWNDLPLLQSMTRLPIILKGILTKEDAELAVKHNIRGIIVSNHGGRQLDEVPASIDALREVVAAVNGKIEVYMDGGVRTGNDVLKALALGARCIFLGRPIIWGLACKGEDGVKEVLDILKEELHTCMALSGCRSVAEISPDLIQFSRL", "length": 353 }, "evidence": [ { "id": "Q3ZBW2", "url": "https://omabrowser.org/oma/group/Q3ZBW2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NYQ3-1", "protein_name": "2-Hydroxyacid oxidase 2", "gene_name": "HAO2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLVCLTDFQAHAREQLSKSTRDFIEGGADDSITRDDNIAAFKRIRLRPRYLRDVSEVDTRTTIQGEEISAPICIAPTGFHCLVWPDGEMSTARAAQAAGICYITSTFASCSLEDIVIAAPEGLRWFQLYVHPDLQLNKQLIQRVESLGFKALVITLDTPVCGNRRHDIRNQLRRNLTLTDLQSPKKGNAIPYFQMTPISTSLCWNDLSWFQSITRLPIILKGILTKEDAELAVKHNVQGIIVSNHGGRQLDEVLASIDALTEVVAAVKGKIEVYLDGGVRTGNDVLKALALGAKCIFLGRPILWGLACKGEHGVKEVLNILTNEFHTSMALTGCRSVAEINRNLVQFSRL", "length": 351 }, "evidence": [ { "id": "Q3ZBW2", "url": "https://omabrowser.org/oma/group/Q3ZBW2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "peroxisomal matrix", "id": "GO:0005782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005782", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2" } ], "pmid": "" }, { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "fatty acid oxidation", "id": "GO:0019395", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019395", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "FMN binding", "id": "GO:0010181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010181", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2" } ], "pmid": "" }, { "name": "(S)-2-hydroxy-acid oxidase activity", "id": "GO:0003973", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003973", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBW2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16789", "name": "", "equation": "a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SC38-1", "Q3ZBW2-1" ], "evidence": [ { "id": "16789", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16789" } ] }, { "id": "67940", "name": "", "equation": "2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SC38-1", "Q3ZBW2-1" ], "evidence": [ { "id": "67940", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67940" } ] }, { "id": "67944", "name": "", "equation": "2-hydroxyhexadecanoate + O2 = 2-oxohexadecanoate + H2O2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBW2-1" ], "evidence": [ { "id": "67944", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67944" } ] }, { "id": "R-BTA-6787811", "name": "HAO2 tetramer oxidises 2OH-PALM", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal matrix", "input_participant_list": [ "R-ALL-6787810" ], "output_participant_list": [ "R-ALL-6787814" ], "enzyme_list": [ "Q3ZBW2-1" ], "evidence": [ { "id": "R-BTA-6787811", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6787811" } ] }, { "id": "R-BTA-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LQH8-1", "Q3SZP5-1", "A0AAA9TBR3-1", "A0AAA9TZC7-1", "A0A3Q1LS67-1", "A0AAA9SXG3-1", "F1MYR5-1", "O19094-1", "Q29448-1", "Q3SX23-1", "F1MQP2-1", "F1MVP8-1", "A0AAA9TYP4-1", "Q24K02-1", "F6RWU6-1", "A0A3Q1LTU2-1", "A0A3Q1LYY4-1", "A0AAA9TW47-1", "A0AAA9SND8-1", "F1MV74-1", "P00432-1", "A0A140T8A5-1", "Q29RU9-1", "Q3ZBW2-1", "A0AAA9SC38-1", "A0AAA9SAI8-1" ], "evidence": [ { "id": "R-BTA-9033235", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033235" } ] }, { "id": "R-BTA-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LQH8-1", "Q3SZP5-1", "A0AAA9TBR3-1", "A0AAA9TZC7-1", "A0A3Q1LS67-1", "A0AAA9SXG3-1", "F1MYR5-1", "O19094-1", "Q29448-1", "Q3SX23-1", "F1MQP2-1", "F1MVP8-1", "A0AAA9TYP4-1", "Q24K02-1", "F6RWU6-1", "A0A3Q1LTU2-1", "A0A3Q1LYY4-1", "A0AAA9TW47-1", "A0AAA9SND8-1", "F1MV74-1", "P00432-1", "A0A140T8A5-1", "Q29RU9-1", "Q3ZBW2-1", "A0AAA9SC38-1", "A0AAA9SAI8-1" ], "evidence": [ { "id": "R-BTA-9033236", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033236" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-6787810", "participant_name": "2OH-PALM [peroxisomal matrix]", "crossref": [ { "id": "65097", "database": "ChEBI", "url": "" }, { "id": "ZINC000014278032", "database": "ZINC", "url": "" }, { "id": "ZINC000014278035", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-6787814", "participant_name": "2oxo-PALM [peroxisomal matrix]", "crossref": [ { "id": "176593", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A140T8A5", "gene_name": "IDH1", "activity": [ { "ec_number": "1.1.1.42", "activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] }, { "ec_number": "1.1.1.42", "activity": "", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] } ] }, { "uniprot_ac": "A0A3Q1LQH8", "gene_name": "GNPAT", "activity": [ { "ec_number": "2.3.1.42", "activity": "dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA.", "evidence": [ { "id": "A0A3Q1LQH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQH8" } ] }, { "ec_number": "2.3.1.42", "activity": "", "evidence": [ { "id": "A0A3Q1LQH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LS67", "gene_name": "ECH1", "activity": [ { "ec_number": "5.3.3.21", "activity": "a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA.", "evidence": [ { "id": "A0A3Q1LS67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS67" } ] }, { "ec_number": "5.3.3.21", "activity": "", "evidence": [ { "id": "A0A3Q1LS67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS67" } ] } ] }, { "uniprot_ac": "A0A3Q1LTU2", "gene_name": "PEX10", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LTU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTU2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LTU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LYY4", "gene_name": "CRAT", "activity": [ { "ec_number": "2.3.1.137", "activity": "octanoyl-CoA + (R)-carnitine = O-octanoyl-(R)-carnitine + CoA.", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ] }, { "ec_number": "2.3.1.7", "activity": "(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA.", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ] }, { "ec_number": "2.3.1.137", "activity": "", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ] }, { "ec_number": "2.3.1.7", "activity": "", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ] } ] }, { "uniprot_ac": "A0AAA9SAI8", "gene_name": "TYSND1", "activity": [ { "ec_number": "3.4.21.-", "activity": "", "evidence": [ { "id": "A0AAA9SAI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI8" } ] } ] }, { "uniprot_ac": "A0AAA9SC38", "gene_name": "HAO1", "activity": [ { "ec_number": "1.1.3.15", "activity": "glycolate + O2 = glyoxylate + H2O2.", "evidence": [ { "id": "A0AAA9SC38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38" } ] }, { "ec_number": "1.1.3.15", "activity": "", "evidence": [ { "id": "A0AAA9SC38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38" } ] } ] }, { "uniprot_ac": "A0AAA9SND8", "gene_name": "EHHADH", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "4.2.1.17", "activity": "(3S)-3-hydroxyadipyl-CoA = (E)-2,3-didehydroadipoyl-CoA + H2O.", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "5.3.3.8", "activity": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "4.2.1.17", "activity": "", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "5.3.3.8", "activity": "", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] } ] }, { "uniprot_ac": "A0AAA9SXG3", "gene_name": "DAO", "activity": [ { "ec_number": "1.4.3.3", "activity": "D-lysine + O2 + H2O = 6-amino-2-oxohexanoate + H2O2 + NH4(+).", "evidence": [ { "id": "A0AAA9SXG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG3" } ] }, { "ec_number": "1.4.3.3", "activity": "", "evidence": [ { "id": "A0AAA9SXG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG3" } ] } ] }, { "uniprot_ac": "A0AAA9TBR3", "gene_name": "PAOX", "activity": [ { "ec_number": "1.5.3.13", "activity": "N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2.", "evidence": [ { "id": "A0AAA9TBR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3" } ] }, { "ec_number": "1.5.3.13", "activity": "", "evidence": [ { "id": "A0AAA9TBR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3" } ] } ] }, { "uniprot_ac": "A0AAA9TW47", "gene_name": "GSTK1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0AAA9TW47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW47" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0AAA9TW47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW47" } ] } ] }, { "uniprot_ac": "A0AAA9TYP4", "gene_name": "PECR", "activity": [ { "ec_number": "1.3.1.38", "activity": "a (2E)-enoyl-CoA + NADPH + H(+) = a 2,3-saturated acyl-CoA + NADP(+).", "evidence": [ { "id": "A0AAA9TYP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYP4" } ] }, { "ec_number": "1.3.1.38", "activity": "", "evidence": [ { "id": "A0AAA9TYP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYP4" } ] } ] }, { "uniprot_ac": "A0AAA9TZC7", "gene_name": "ECI2", "activity": [ { "ec_number": "5.3.3.8", "activity": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.", "evidence": [ { "id": "A0AAA9TZC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZC7" } ] }, { "ec_number": "5.3.3.8", "activity": "", "evidence": [ { "id": "A0AAA9TZC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZC7" } ] } ] }, { "uniprot_ac": "F1MQP2", "gene_name": "SLC27A2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "F1MQP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQP2" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "F1MQP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQP2" } ] } ] }, { "uniprot_ac": "F1MV74", "gene_name": "SCP2", "activity": [ { "ec_number": "2.3.1.176", "activity": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA.", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.16", "activity": "an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.155", "activity": "tetradecanoyl-CoA + acetyl-CoA = 3-oxohexadecanoyl-CoA + CoA.", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.155", "activity": "", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.176", "activity": "", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] } ] }, { "uniprot_ac": "F1MVP8", "gene_name": "HACL1", "activity": [ { "ec_number": "4.1.2.63", "activity": "2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA.", "evidence": [ { "id": "F1MVP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVP8" } ] }, { "ec_number": "4.1.2.63", "activity": "", "evidence": [ { "id": "F1MVP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVP8" } ] } ] }, { "uniprot_ac": "F1MYR5", "gene_name": "NOS2", "activity": [ { "ec_number": "1.14.13.39", "activity": "2 L-arginine + 3 NADPH + 4 O2 + H(+) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H2O.", "evidence": [ { "id": "F1MYR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYR5" } ] }, { "ec_number": "1.14.13.39", "activity": "", "evidence": [ { "id": "F1MYR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYR5" } ] } ] }, { "uniprot_ac": "F6RWU6", "gene_name": "ACOT8", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.3", "activity": "succinyl-CoA + H2O = succinate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.11", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.5", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.27", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] } ] }, { "uniprot_ac": "O19094", "gene_name": "CROT", "activity": [ { "ec_number": "2.3.1.137", "activity": "octanoyl-CoA + (R)-carnitine = O-octanoyl-(R)-carnitine + CoA.", "evidence": [ { "id": "O19094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O19094" } ] }, { "ec_number": "2.3.1.137", "activity": "", "evidence": [ { "id": "O19094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O19094" } ] } ] }, { "uniprot_ac": "P00432", "gene_name": "CAT", "activity": [ { "ec_number": "1.11.1.6", "activity": "2 H2O2 = O2 + 2 H2O.", "evidence": [ { "id": "P00432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00432" } ] }, { "ec_number": "1.11.1.6", "activity": "", "evidence": [ { "id": "P00432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00432" } ] } ] }, { "uniprot_ac": "Q24K02", "gene_name": "IDE", "activity": [ { "ec_number": "3.4.24.56", "activity": "Degradation of insulin, glucagon and other polypeptides. No action on proteins.", "evidence": [ { "id": "Q24K02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K02" } ] }, { "ec_number": "3.4.24.56", "activity": "", "evidence": [ { "id": "Q24K02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K02" } ] } ] }, { "uniprot_ac": "Q29448", "gene_name": "HMGCL", "activity": [ { "ec_number": "4.1.3.4", "activity": "(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.", "evidence": [ { "id": "Q29448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29448" } ] }, { "ec_number": "4.1.3.4", "activity": "", "evidence": [ { "id": "Q29448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29448" } ] } ] }, { "uniprot_ac": "Q29RU9", "gene_name": "PIPOX", "activity": [ { "ec_number": "1.5.3.1", "activity": "sarcosine + O2 + H2O = formaldehyde + glycine + H2O2.", "evidence": [ { "id": "Q29RU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU9" } ] }, { "ec_number": "1.5.3.7", "activity": "L-pipecolate + O2 = L-1-piperideine-6-carboxylate + H2O2 + H(+).", "evidence": [ { "id": "Q29RU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU9" } ] }, { "ec_number": "1.5.3.1", "activity": "", "evidence": [ { "id": "Q29RU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU9" } ] }, { "ec_number": "1.5.3.7", "activity": "", "evidence": [ { "id": "Q29RU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU9" } ] } ] }, { "uniprot_ac": "Q3SX23", "gene_name": "LONP2", "activity": [ { "ec_number": "3.4.21.-", "activity": "", "evidence": [ { "id": "Q3SX23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX23" } ] }, { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "Q3SX23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX23" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "Q3SX23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX23" } ] } ] }, { "uniprot_ac": "Q3SZP5", "gene_name": "ACOX1", "activity": [ { "ec_number": "1.3.3.6", "activity": "a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2.", "evidence": [ { "id": "Q3SZP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZP5" } ] }, { "ec_number": "1.3.3.6", "activity": "", "evidence": [ { "id": "Q3SZP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZP5" } ] } ] }, { "uniprot_ac": "Q3ZBW2", "gene_name": "HAO2", "activity": [ { "ec_number": "1.1.3.15", "activity": "glycolate + O2 = glyoxylate + H2O2.", "evidence": [ { "id": "Q3ZBW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2" } ] }, { "ec_number": "1.1.3.15", "activity": "", "evidence": [ { "id": "Q3ZBW2", "database": "UniProtKB", "url": 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Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. 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"categories": [ "Protein Classification" ] }, { "id": "IPR029064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050257", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050257", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520891", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520891", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EDNYEAR", "url": "https://omabrowser.org/oma/group/EDNYEAR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E950", "url": "https://www.orthodb.org/?gene=Q5E950", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23105", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23105", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01248", "url": 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"https://www.uniprot.org/uniprotkb/Q5E950-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTKIKADPDGPEAQADACCGERTYHELLVNLNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFINKGEKGIMVLAGDTLPIEVYCHLPVMCEDRNLPYVYIPSKTDLGAAAGSKRPTCVIMVKPHEEYQEAYDECLEEVQALPPPM", "length": 153, "header": "sp|Q5E950-1|NHP2_BOVIN Isoform 1 of H/ACA ribonucleoprotein complex subunit 2 OS=Bos taurus OX=9913 GN=NHP2 PE=2 SV=1 CANONICAL=Q5E950-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQ23-1", "url": "https://www.uniprot.org/uniprotkb/Q5E950/entry#A0AAA9SQ23-1", "sequence": { "sequence": "MTKIKADPDGPEAQADACCGERTYHELLVNLNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFINKGEKGTWVQPLALSAPPA", "length": 90, "header": "tr|A0AAA9SQ23-1|NHP2_BOVIN Computationally mapped isoform of H/ACA ribonucleoprotein complex subunit 2 OS=Bos taurus OX=9913 GN=NHP2 PE=2 SV=1 CANONICAL=Q5E950-1" }, "locus": { "chromosome": "7", "start_pos": 39247953, "end_pos": 39244389, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132941.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132941.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087471.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087471.1" } ] } }, { "isoform_ac": "Q5E950-1", "url": "https://www.uniprot.org/uniprotkb/Q5E950/entry#Q5E950-1", "sequence": { "sequence": "MTKIKADPDGPEAQADACCGERTYHELLVNLNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFINKGEKGIMVLAGDTLPIEVYCHLPVMCEDRNLPYVYIPSKTDLGAAAGSKRPTCVIMVKPHEEYQEAYDECLEEVQALPPPM", "length": 153, "header": "sp|Q5E950-1|NHP2_BOVIN Isoform 1 of H/ACA ribonucleoprotein complex subunit 2 OS=Bos taurus OX=9913 GN=NHP2 PE=2 SV=1 CANONICAL=Q5E950-1" }, "locus": { "chromosome": "7", "start_pos": 39247953, "end_pos": 39244306, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008363.4", "url": "https://www.ensembl.org/id/ENSBTAT00000008363.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008363.3", "url": "https://www.ensembl.org/id/ENSBTAP00000008363.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E950", "url": "https://www.uniprot.org/uniprotkb/Q5E950" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:520891", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520891", "resource": "KEGG Pathway" }, { "id": "R-BTA-171319", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-171319", "resource": "Reactome", "description": "Telomere Extension By Telomerase" }, { "id": "R-BTA-174430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174430", "resource": "Reactome", "description": "Telomere C-strand synthesis initiation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BMH8-1", "protein_name": "H/ACA ribonucleoprotein complex subunit 2", "gene_name": "NHP2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTRKRFLKRRPRVLGSWALGCRVAAMTKIKADPDGPEAQADACCGERTYHELLVNLNPIAQPLASRKLTRKLYKCIKKAVKQKQIRRGVKEVQKFINKGEKGIMVLAGDTLPVEVYCHLPVMCEDRNLPYVYIPSKTDLGAAAGSKRPTCVIMVKPHEEYQEAYDECLEEVQALPPPM", "length": 178 }, "evidence": [ { "id": "Q5E950", "url": "https://omabrowser.org/oma/group/Q5E950/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H2E1-1", "protein_name": "H/ACA ribonucleoprotein complex subunit 2", "gene_name": "Nhp2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": 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protein", "gene_name": "nhp2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTKVKKEKAGEEETGGTEKSYQELIANINPIANPLASRKLSKKLYKCVKKAAKVKQIRRGVKEVQKFINKGETGIVVFAGDTLPIDVYCHLPIMCEDRSLPYAYVPSKVDLGSSAGSKRPTCVIMIKPHDEYKEAYDECVEEVTSLPKPI", "length": 150 }, "evidence": [ { "id": "Q5E950", "url": "https://omabrowser.org/oma/group/Q5E950/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9CRB2-1", "protein_name": "H/ACA ribonucleoprotein complex subunit 2", "gene_name": "Nhp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTKVKAAPEESEAQAEGCSEERTYKELLVNLNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFVNKGEKGIMVLAGDTLPIEVYCHLPVLCEDQNLPYVYIPSKTDLGAATGSKRPTCVIMVKPHEEYQETYDKCLEEVQALPTPL", "length": 153 }, "evidence": [ { "id": "Q5E950", "url": "https://omabrowser.org/oma/group/Q5E950/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NX24-1", "protein_name": "H/ACA ribonucleoprotein complex subunit 2", "gene_name": "NHP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTKIKADPDGPEAQAEACSGERTYQELLVNQNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFVNKGEKGIMVLAGDTLPIEVYCHLPVMCEDRNLPYVYIPSKTDLGAAAGSKRPTCVIMVKPHEEYQEAYDECLEEVQSLPLPL", "length": 153 }, "evidence": [ { "id": "Q5E950", "url": "https://omabrowser.org/oma/group/Q5E950/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9V3U2-1", "protein_name": "H/ACA ribonucleoprotein complex subunit 2", "gene_name": "NHP2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGKVKVERSEDADESVVASGDVTIKEEESYDDKLIFVNAIAKPMAGKKLAKKCYKLVKKAMKHKTFLRNGLKDVQTRLRKGETGICIFAGDVTPVDIMCHLPAVCEEKGIPYTYTPSRADLGAAMGVKRGTVALLVRQNEEYKDLYDEVKEELSALNIPV", "length": 160 }, "evidence": [ { "id": "Q5E950", "url": "https://omabrowser.org/oma/group/Q5E950/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Cajal body", "id": "GO:0015030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015030", "evidence": [ { "database": "UniProtKB", "id": "Q5E950", "url": "https://www.uniprot.org/uniprotkb/Q5E950" } ], "pmid": "" }, { "name": "telomerase holoenzyme complex", "id": "GO:0005697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005697", "evidence": [ { "database": "UniProtKB", "id": "Q5E950", "url": "https://www.uniprot.org/uniprotkb/Q5E950" } ], "pmid": "" }, { "name": "box H/ACA snoRNP complex", "id": "GO:0031429", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031429", "evidence": [ { "database": "UniProtKB", "id": "Q5E950", "url": "https://www.uniprot.org/uniprotkb/Q5E950" } ], "pmid": "" }, { "name": "box H/ACA telomerase RNP complex", "id": "GO:0090661", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090661", "evidence": [ { "database": "UniProtKB", "id": "Q5E950", "url": "https://www.uniprot.org/uniprotkb/Q5E950" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "rRNA pseudouridine synthesis", "id": "GO:0031118", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031118", "evidence": [ { "database": "UniProtKB", "id": "Q5E950", "url": "https://www.uniprot.org/uniprotkb/Q5E950" } ], "pmid": "" }, { "name": "snRNA pseudouridine synthesis", "id": "GO:0031120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031120", "evidence": [ { "database": "UniProtKB", "id": "Q5E950", "url": "https://www.uniprot.org/uniprotkb/Q5E950" } ], "pmid": "" }, { "name": "telomere maintenance via telomerase", "id": "GO:0007004", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007004", "evidence": [ { "database": "UniProtKB", "id": "Q5E950", "url": "https://www.uniprot.org/uniprotkb/Q5E950" } ], "pmid": "" }, { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "Q5E950", "url": "https://www.uniprot.org/uniprotkb/Q5E950" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "box H/ACA snoRNA binding", "id": "GO:0034513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034513", "evidence": [ { "database": "UniProtKB", "id": "Q5E950", "url": "https://www.uniprot.org/uniprotkb/Q5E950" } ], "pmid": "" }, { "name": "telomerase RNA binding", "id": "GO:0070034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070034", "evidence": [ { "database": "UniProtKB", "id": "Q5E950", "url": "https://www.uniprot.org/uniprotkb/Q5E950" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q5E950", "url": "https://www.uniprot.org/uniprotkb/Q5E950" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E950-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 153, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E950-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E950" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBP2-1", "uniprot_ac": "Q3ZBP2", "uniprot_id": "NEPR1_BOVIN", "mass": { "chemical_mass": 14267.0, "monoisotopic_mass": 14267.0 }, "refseq": { "ac": "NP_001029475", "name": "nuclear envelope phosphatase-regulatory subunit 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029475" }, "gene_names": [ { "name": "CNEP1R1", "type": "recommended", "evidence": [ { "id": "Q3ZBP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP2" } ] }, { "name": "CNEP1R1", "type": "synonym", "evidence": [ { "id": "NP_001029475", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029475" } ] }, { "name": "TMEM188", "type": "synonym", "evidence": [ { "id": "NP_001029475", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029475" }, { "id": "Q3ZBP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP2" } ] } ], "protein_names": [ { "name": "Nuclear envelope phosphatase-regulatory subunit 1", "type": "recommended", "evidence": [ { "id": "Q3ZBP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP2/entry#names_and_taxonomy" } ] }, { "name": "Transmembrane protein 188", "type": "synonym", "evidence": [ { "id": "Q3ZBP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP2/entry#names_and_taxonomy" } ] }, { "name": "nuclear envelope phosphatase-regulatory subunit 1", "type": "synonym", "evidence": [ { "id": "NP_001029475", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029475" } ] }, { "name": "transmembrane protein 188", "type": "synonym", "evidence": [ { "id": "NP_001029475", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029475" } ] } ], "function": [ { "annotation": "Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CNEP1R1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP2", "locus": { "chromosome": "18", "start_pos": 18465539, "end_pos": 18450876, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033078", "url": "https://www.ensembl.org/id/ENSBTAG00000033078" } ] } } ], "crossref": [ { "id": "Q3ZBP2", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBP2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033078", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033078", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507593", "url": "https://www.ncbi.nlm.nih.gov/gene/507593", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019168", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019168", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507593", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507593", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NHPFFAI", "url": "https://omabrowser.org/oma/group/NHPFFAI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBP2", "url": "https://www.orthodb.org/?gene=Q3ZBP2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20996", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20996", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20996:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20996:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09771", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09771", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-4419969", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4419969", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029475", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SR37", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR37", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR37-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR37-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBP2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBP2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNSLEQAEDLKAFERRLTEYIHCLQPATGRWRMLLIVVSVCTATGAWNWLIDPETQKVSFFTSLWNHPFFTISCITLIGLFFAGIHKRVVAPSIIAARCRTVLAEYNMSCDDTGKLILKPRPHVQ", "length": 125, "header": "sp|Q3ZBP2-1|NEPR1_BOVIN Isoform 1 of Nuclear envelope phosphatase-regulatory subunit 1 OS=Bos taurus OX=9913 GN=CNEP1R1 PE=2 SV=1 CANONICAL=Q3ZBP2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SR37-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP2/entry#A0AAA9SR37-1", "sequence": { "sequence": "VQDLKQLEYLKFIAFERRLTEYIHCLQPATGRWRMLLIVVSVCTATGAWNWLIDPETQKVSFFTSLWNHPFFTISCITLIGLFFAGIHKRVVAPSIIAARCRTVLAEYNMSCDDVSIFIRKL", "length": 122, "header": "tr|A0AAA9SR37-1|NEPR1_BOVIN Computationally mapped isoform of Nuclear envelope phosphatase-regulatory subunit 1 OS=Bos taurus OX=9913 GN=CNEP1R1 PE=2 SV=1 CANONICAL=Q3ZBP2-1" }, "locus": { "chromosome": "18", "start_pos": 18459430, "end_pos": 18451985, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125452.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125452.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086439.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086439.1" } ] } }, { "isoform_ac": "Q3ZBP2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP2/entry#Q3ZBP2-1", "sequence": { "sequence": "MNSLEQAEDLKAFERRLTEYIHCLQPATGRWRMLLIVVSVCTATGAWNWLIDPETQKVSFFTSLWNHPFFTISCITLIGLFFAGIHKRVVAPSIIAARCRTVLAEYNMSCDDTGKLILKPRPHVQ", "length": 125, "header": "sp|Q3ZBP2-1|NEPR1_BOVIN Isoform 1 of Nuclear envelope phosphatase-regulatory subunit 1 OS=Bos taurus OX=9913 GN=CNEP1R1 PE=2 SV=1 CANONICAL=Q3ZBP2-1" }, "locus": { "chromosome": "18", "start_pos": 18464220, "end_pos": 18451005, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152764.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152764.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107646.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107646.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507593", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507593", "resource": "KEGG Pathway" }, { "id": "R-BTA-4419969", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4419969", "resource": "Reactome", "description": "Depolymerization of the Nuclear Lamina" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BAE1-1", "protein_name": "Nuclear envelope phosphatase-regulatory subunit 1", "gene_name": "CNEP1R1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNSLEQAEDLKAFERRLTEYIHCLQPATGRWRMLLIVVSVCTATGAWNWLIDPETQKVSFFTSLWNHPFFTISCITLIGLFFAGIHKRVVAPSMYPLLQIIAARCRTVLAEYNMSCDDTGKLILKPRPHVQ", "length": 131 }, "evidence": [ { "id": "Q3ZBP2", "url": "https://omabrowser.org/oma/group/Q3ZBP2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZVT8-1", "protein_name": "Nuclear envelope phosphatase-regulatory subunit 1", "gene_name": "CNEP1R1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNLKCCPSLNSNLNDLKAFERRLTEYIACLQPATGRWRMILIVVSVCTATGAWNWLIDPETQKVSFFTSLWNHPFFTISCITLIGLFFAGIHKRVVAPSIIAARCRTVLAEYNMSCDDTGKLILKPRPHVQ", "length": 131 }, "evidence": [ { "id": "Q3ZBP2", "url": "https://omabrowser.org/oma/group/Q3ZBP2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q3UJ81-1", "protein_name": "Nuclear envelope phosphatase-regulatory subunit 1", "gene_name": "Cnep1r1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNSLEQAEDLKAFERRLTEYIHCLQPATGRWRMLLIVVSVCTATGAWNWLIDPETQKVSFFTSLWNHPFFTISCITLIGLFFAGIHKRVVAPSIIAARCRTVLAEYNMSCDDTGKLILKPRPHVQ", "length": 125 }, "evidence": [ { "id": "Q3ZBP2", "url": "https://omabrowser.org/oma/group/Q3ZBP2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q561X0-1", "protein_name": "Nuclear envelope phosphatase-regulatory subunit 1", "gene_name": "cnep1r1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNSLEQAEDLKAFERRLTEYVSCLQPATGRWRMILIVVSVCTATGAWNWLIDPDTQKVSFFSSLWNHPFFTISCVTLIGLFFAGIHKRVVAPSIIAARCRTVLAEYNMSCDDTGKLILKPRPHIQ", "length": 125 }, "evidence": [ { "id": "Q3ZBP2", "url": "https://omabrowser.org/oma/group/Q3ZBP2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8N9A8-1", "protein_name": "Nuclear envelope phosphatase-regulatory subunit 1", "gene_name": "CNEP1R1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNSLEQAEDLKAFERRLTEYIHCLQPATGRWRMLLIVVSVCTATGAWNWLIDPETQKVSFFTSLWNHPFFTISCITLIGLFFAGIHKRVVAPSIIAARCRTVLAEYNMSCDDTGKLILKPRPHVQ", "length": 125 }, "evidence": [ { "id": "Q3ZBP2", "url": "https://omabrowser.org/oma/group/Q3ZBP2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8T0B1-1", "protein_name": "Nuclear envelope phosphatase-regulatory subunit 1 homolog", "gene_name": "Cnep1r2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEPSACEDLKAFERRLTEVVSSYRPSTFRWRKLLAVVLSAMSMCTAISAWYWLRDPRTTVVPLTESLWIHPVFTVATLTLVVLFILGIQKLVIAPQIITSRTRMVLGDFNMSCDDTGKLILKPRQSNNNST", "length": 131 }, "evidence": [ { "id": "Q3ZBP2", "url": "https://omabrowser.org/oma/group/Q3ZBP2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP2", "url": 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{ "uniprot_canonical_ac": "Q6WZ19-1", "uniprot_ac": "Q6WZ19", "uniprot_id": "NGB_BOVIN", "mass": { "chemical_mass": 16904.0, "monoisotopic_mass": 16904.0 }, "refseq": { "ac": "NP_001001853", "name": "neuroglobin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001853" }, "gene_names": [ { "name": "NGB", "type": "recommended", "evidence": [ { "id": "Q6WZ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19" } ] }, { "name": "GLNH", "type": "synonym", "evidence": [ { "id": "NP_001001853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001853" } ] }, { "name": "NGB", "type": "synonym", "evidence": [ { "id": "NP_001001853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001853" } ] } ], "protein_names": [ { "name": "Neuroglobin", "type": "recommended", "evidence": [ { "id": "Q6WZ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19/entry#names_and_taxonomy" } ] }, { "name": "1.7.-.-", "type": "synonym", "evidence": [ { "id": "Q6WZ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19/entry#names_and_taxonomy" } ] }, { "name": "Nitrite reductase", "type": "synonym", "evidence": [ { "id": "Q6WZ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19/entry#names_and_taxonomy" } ] }, { "name": "globin H", "type": "synonym", "evidence": [ { "id": "NP_001001853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001853" } ] }, { "name": "neuroglobin", "type": "synonym", "evidence": [ { "id": "NP_001001853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001853" } ] }, { "name": "nitrite reductase", "type": "synonym", "evidence": [ { "id": "NP_001001853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001853" } ] } ], "function": [ { "annotation": "Monomeric globin with a bis-histidyl six-coordinate heme-iron atom through which it can bind dioxygen, carbon monoxide and nitric oxide. Could help transport oxygen and increase its availability to the metabolically active neuronal tissues, though its low quantity in tissues as well as its high affinity for dioxygen, which may limit its oxygen-releasing ability, argue against it. The ferrous/deoxygenated form exhibits a nitrite reductase activity and it could produce nitric oxide which in turn inhibits cellular respiration in response to hypoxia. In its ferrous/deoxygenated state, it may also exhibit GDI (Guanine nucleotide Dissociation Inhibitor) activity toward heterotrimeric G-alpha proteins, thereby regulating signal transduction to facilitate neuroprotective responses in the wake of hypoxia and associated oxidative stress.", "evidence": [ { "database": "UniProtKB", "id": "Q6WZ19", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19#function" }, { "database": "UniProtKB", "id": "Q9NPG2", "url": "https://www.uniprot.org/uniprotkb/Q9NPG2#function" }, { "database": "UniProtKB", "id": "A0AAA9SS12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS12#function" }, { "database": "UniProtKB", "id": "ARBA00045651", "url": "https://www.uniprot.org/uniprotkb/ARBA00045651#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6WZ19", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NGB", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19", "locus": { "chromosome": "10", "start_pos": 88465536, "end_pos": 88470675, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016285", "url": "https://www.ensembl.org/id/ENSBTAG00000016285" } ] } } ], "crossref": [ { "id": "Q6WZ19", "url": "https://alphafold.ebi.ac.uk/entry/Q6WZ19", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016285", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016285", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08920", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08920", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "414920", "url": "https://www.ncbi.nlm.nih.gov/gene/414920", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012292", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012292", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050532", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050532", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:414920", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:414920", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GRKLMAM", "url": "https://omabrowser.org/oma/group/GRKLMAM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q6WZ19", "url": "https://www.orthodb.org/?gene=Q6WZ19", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46458", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46458", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46458:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46458:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00042", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00042", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8981607", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8981607", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001001853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001853", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "77711", "url": "https://www.rhea-db.org/rhea/77711", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SS12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS12-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6WZ19", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6WZ19-1", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELPEPELIRQSWREVSRSPLEHGTVLFARLFDLEPDLLPLFQYNCRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLAGLGRKHRAVGVKLSSFSTVGESLLYMLEKCLGPAFTPATRAAWSQLYGAVVQAMSRGWGGE", "length": 151, "header": "sp|Q6WZ19-1|NGB_BOVIN Isoform 1 of Neuroglobin OS=Bos taurus OX=9913 GN=NGB PE=2 SV=2 CANONICAL=Q6WZ19-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SS12-1", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19/entry#A0AAA9SS12-1", "sequence": { "sequence": "MSRRRPSRRRRSGARRLVAQPLRLFPRRPRHVLASAHTPLPAELSGGRPGSSPAAHLPILWAPRCGPSPAVCLLSVLSLGDDCRGAHRCPYGEKPRLFDLEPDLLPLFQYNCRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLAGLGRKHRAVGVKLSSFSTVGESLLYMLEKCLGPAFTPATRAAWSQLYGAVVQAMSRGWGGE", "length": 217, "header": "tr|A0AAA9SS12-1|NGB_BOVIN Computationally mapped isoform of Neuroglobin OS=Bos taurus OX=9913 GN=NGB PE=2 SV=1 CANONICAL=Q6WZ19-1" }, "locus": { "chromosome": "10", "start_pos": 88470233, "end_pos": 88466540, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120657.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120657.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086751.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086751.1" } ] } }, { "isoform_ac": "Q6WZ19-1", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19/entry#Q6WZ19-1", "sequence": { "sequence": "MELPEPELIRQSWREVSRSPLEHGTVLFARLFDLEPDLLPLFQYNCRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLAGLGRKHRAVGVKLSSFSTVGESLLYMLEKCLGPAFTPATRAAWSQLYGAVVQAMSRGWGGE", "length": 151, "header": "sp|Q6WZ19-1|NGB_BOVIN Isoform 1 of Neuroglobin OS=Bos taurus OX=9913 GN=NGB PE=2 SV=2 CANONICAL=Q6WZ19-1" }, "locus": { "chromosome": "10", "start_pos": 88470377, "end_pos": 88466540, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021661.4", "url": "https://www.ensembl.org/id/ENSBTAT00000021661.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021661.2", "url": "https://www.ensembl.org/id/ENSBTAP00000021661.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Neuroglobin and cytoglobin: genes, proteins and evolution.", "journal": "IUBMB Life", "date": "2004", "authors": "Burmester Thorsten, Haberkamp Mark, Mitz Stephanie, Roesner Anja, Schmidt Marc, Ebner Bettina, Gerlach Frank, Fuchs Christine, Hankeln Thomas", "evidence": [ { "database": "UniProtKB", "id": "Q6WZ19", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19" } ], "reference": [ { "type": "PubMed", "id": "15804835", "url": "https://glygen.org/publication/PubMed/15804835" } ] } ], "pathway": [ { "id": "bta:414920", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:414920", "resource": "KEGG Pathway" }, { "id": "R-BTA-8981607", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8981607", "resource": "Reactome", "description": "Intracellular oxygen transport" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2N370-1", "protein_name": "Neuroglobin", "gene_name": "Ngb", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MELPEPELIRQSWQAVSRSPLEHGTVLFSRLFTLEPSLLPLFQYNGRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLAGLGRKHRAVGVRLSSFSVGSETVGESLLYMLENCLGPDFTPATKAAWSQLYGAVVQAMSRDWDRE", "length": 155 }, "evidence": [ { "id": "Q6WZ19", "url": "https://omabrowser.org/oma/group/Q6WZ19/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6WZ17-1", "protein_name": "Neuroglobin", "gene_name": "NGB", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MERPEHELIRQSWRAVSRSPLEHGTVLFARLFDLEPDLLPLFQYNCRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLAGLGRKHRAVGVKLSSFSAVGESLLYMLEKCLGPTFTPATRAAWSQLYGAVVQAMSRGWNGE", "length": 151 }, "evidence": [ { "id": "Q6WZ19", "url": "https://omabrowser.org/oma/group/Q6WZ19/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q90YJ2-1", "protein_name": "Neuroglobin", "gene_name": "ngb", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEKLSEKDKGLIRDSWESLGKNKVPHGIVLFTRLFELDPALLTLFSYSTNCGDAPECLSSPEFLEHVTKVMLVIDAAVSHLDDLHTLEDFLLNLGRKHQAVGVNTQSFALVGESLLYMLQSSLGPAYTTSLRQAWLTMYSIVVSAMTRGWAKNGEHKSN", "length": 159 }, "evidence": [ { "id": "Q6WZ19", "url": "https://omabrowser.org/oma/group/Q6WZ19/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q99JA8-1", "protein_name": "Neuroglobin", "gene_name": "Ngb", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MERPESELIRQSWRAVSRSPLEHGTVLFSRLFALEPSLLPLFQYNGRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLATLGRKHRAVGVRLSSFSTVGESLLYMLEKCLGPDFTPATRTAWSQLYGAVVQAMSRGWDGE", "length": 151 }, "evidence": [ { "id": "Q6WZ19", "url": "https://omabrowser.org/oma/group/Q6WZ19/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9ER97-1", "protein_name": "Neuroglobin", "gene_name": "Ngb", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERPESELIRQSWRVVSRSPLEHGTVLFARLFALEPSLLPLFQYNGRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLTSLGRKHRAVGVRLSSFSTVGESLLYMLEKCLGPDFTPATRTAWSRLYGAVVQAMSRGWDGE", "length": 151 }, "evidence": [ { "id": "Q6WZ19", "url": "https://omabrowser.org/oma/group/Q6WZ19/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NPG2-1", "protein_name": "Neuroglobin", "gene_name": "NGB", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MERPEPELIRQSWRAVSRSPLEHGTVLFARLFALEPDLLPLFQYNCRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHRAVGVKLSSFSTVGESLLYMLEKCLGPAFTPATRAAWSQLYGAVVQAMSRGWDGE", "length": 151 }, "evidence": [ { "id": "Q6WZ19", "url": "https://omabrowser.org/oma/group/Q6WZ19/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q6WZ19", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q6WZ19", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q6WZ19", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "Q6WZ19", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19" } ], "pmid": "" }, { "name": "GDP-dissociation inhibitor activity", "id": "GO:0005092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005092", "evidence": [ { "database": "UniProtKB", "id": "Q6WZ19", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19" } ], "pmid": "" }, { "name": "oxygen binding", "id": "GO:0019825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019825", "evidence": [ { "database": "UniProtKB", "id": "Q6WZ19", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19" } ], "pmid": "" }, { "name": "oxygen carrier activity", "id": "GO:0005344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005344", "evidence": [ { "database": "UniProtKB", "id": "Q6WZ19", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19" } ], "pmid": "" }, { "name": "nitrite reductase activity", "id": "GO:0098809", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098809", "evidence": [ { "database": "UniProtKB", "id": "Q6WZ19", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "response to hypoxia", "id": "GO:0001666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001666", "evidence": [ { "database": "UniProtKB", "id": "Q6WZ19", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19" } ], "pmid": "" }, { "name": "cellular response to hypoxia", "id": "GO:0071456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071456", "evidence": [ { "database": "UniProtKB", "id": "Q6WZ19", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19" } ], "pmid": "" }, { "name": "oxygen transport", "id": "GO:0015671", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015671", "evidence": [ { "database": "UniProtKB", "id": "Q6WZ19", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "77711", "name": "", "equation": "Fe(III)-heme b-[protein] + nitric oxide + H2O = Fe(II)-heme b-[protein] + nitrite + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6WZ19-1", "P02192-1", "E1BMU2-1" ], "evidence": [ { "id": "77711", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/77711" } ] }, { "id": "R-BTA-8981610", "name": "Neuroglobin binds oxygen", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6WZ19-1" ], "evidence": [ { "id": "R-BTA-8981610", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8981610" } ] }, { "id": "R-BTA-8981621", "name": "Neuroglobin:oxygen dissociates", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6WZ19-1" ], "evidence": [ { "id": "R-BTA-8981621", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8981621" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "E1BMU2", "gene_name": "CYGB", "activity": [ { "ec_number": "1.15.1.1", "activity": "2 superoxide + 2 H(+) = H2O2 + O2.", "evidence": [ { "id": "E1BMU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMU2" } ] }, { "ec_number": "1.15.1.1", "activity": "", "evidence": [ { "id": "E1BMU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMU2" } ] } ] }, { "uniprot_ac": "P02192", "gene_name": "MB", "activity": [ { "ec_number": "1.11.1.-", "activity": "", "evidence": [ { "id": "P02192", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P02192" } ] }, { "ec_number": "1.7.-.-", "activity": "", "evidence": [ { "id": "P02192", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P02192" } ] } ] }, { "uniprot_ac": "Q6WZ19", "gene_name": "NGB", "activity": [ { "ec_number": "1.7.-.-", "activity": "", "evidence": [ { "id": "Q6WZ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q6WZ19-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 151, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q6WZ19-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q6WZ19" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q6WZ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6WZ19" }, { "id": "PRU00238", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00238" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Globin", "eco_id": "ECO_0000255", "start_pos": 1, "end_pos": 149, "start_aa": "Met", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBU9-1", "uniprot_ac": "Q3ZBU9", "uniprot_id": "UBXN4_BOVIN", "mass": { "chemical_mass": 56784.0, "monoisotopic_mass": 56784.0 }, "refseq": { "ac": "NP_001030491", "name": "UBX domain-containing protein 4", "summary": "", "url": 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"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030491" } ] }, { "name": "UBX domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001030491", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030491" }, { "id": "Q3ZBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU9/entry#names_and_taxonomy" } ] }, { "name": "UBX domain-containing protein 4", "type": "synonym", "evidence": [ { "id": "NP_001030491", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030491" } ] } ], "function": [ { "annotation": "Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBU9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU9#function" }, { "database": "UniProtKB", "id": "Q92575", "url": "https://www.uniprot.org/uniprotkb/Q92575#function" }, { "database": "UniProtKB", "id": "A0AAA9SUA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA0#function" }, { "database": "UniProtKB", "id": "ARBA00046062", "url": "https://www.uniprot.org/uniprotkb/ARBA00046062#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBU9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBXN4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU9", "locus": { "chromosome": "2", "start_pos": 61587687, "end_pos": 61617749, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015169", "url": "https://www.ensembl.org/id/ENSBTAG00000015169" } ] } } ], "crossref": [ { "id": "Q3ZBU9", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBU9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015169", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015169", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16117", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16117", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "536181", "url": "https://www.ncbi.nlm.nih.gov/gene/536181", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536181", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536181", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FEPNNTS", "url": "https://omabrowser.org/oma/group/FEPNNTS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBU9", "url": "https://www.orthodb.org/?gene=Q3ZBU9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46424", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46424", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46424:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46424:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00789", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00789", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23187", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23187", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030491", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SUA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUA0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUA0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBU9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBU9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLWFQGAIPAAIASAKRSGAVFVVFVAGDDEQSTQMAASWEDEKVTEASSNSFVAIKIDTRSEACLQFSQIYPVVCVPSSFFIGDSGIPLEVIAGSISADELVTRIHKVRQMHSLKGEASLANGSQSEGSVSTPSASFEHNNTSENCQSRNVELCETPSTSDTKSDSATGGESSGQTTVSQEPSGCSNQRPTEDLTVRVERLTKKLEERREEKRKEEEQREIKKEIERRKTGKEMLDYKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLAKQAEMEIKRETSTKERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNFSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTTSMVHSSSGDFWTLLGTVLYPFLAIWRLISNFLFSNPPPAQTSVRAASLETSNLASSSNSEKREPVRKRVLEKRGEDFKKEGKIYRLRTQDDGEDENNTWNGNSTQQM", "length": 508, "header": "sp|Q3ZBU9-1|UBXN4_BOVIN Isoform 1 of UBX domain-containing protein 4 OS=Bos taurus OX=9913 GN=UBXN4 PE=2 SV=2 CANONICAL=Q3ZBU9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUA0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU9/entry#A0AAA9SUA0-1", "sequence": { "sequence": "MAASWEDEKVTEASSNSFVAIKIDTRSEACLQFSQIYPVVCVPSSFFIGDSGIPLEVIAGSISADELVTRIHKVRQMHSLKGEASLANGSQSEGSVSTPSASFEHNNTSENCQSRNVELCETPSTSDTKSDSATGGESSGQTTVSQEPSGCSNQRPTEDLTVRVERLTKKLEERREEKRKEEEQREIKKEIERRKTGKEMLDYKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLAKQAEMEIKRETSTKERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNFSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTTSMVHSSSGDFWTLLGTVLYPFLAIWRLISNFLFSNPPPAQTSVRAASLETSNLASSSNSEKREPVRKRVLEKRGEDFKKEGKIYRLRTQDDGEDENNTWNGNSTQQM", "length": 473, "header": "tr|A0AAA9SUA0-1|UBXN4_BOVIN Computationally mapped isoform of UBX domain-containing protein 4 OS=Bos taurus OX=9913 GN=UBXN4 PE=2 SV=1 CANONICAL=Q3ZBU9-1" }, "locus": { "chromosome": "2", "start_pos": 61611050, "end_pos": 61588167, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104483.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104483.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088910.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088910.1" } ] } }, { "isoform_ac": "Q3ZBU9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU9/entry#Q3ZBU9-1", "sequence": { "sequence": "MLWFQGAIPAAIASAKRSGAVFVVFVAGDDEQSTQMAASWEDEKVTEASSNSFVAIKIDTRSEACLQFSQIYPVVCVPSSFFIGDSGIPLEVIAGSISADELVTRIHKVRQMHSLKGEASLANGSQSEGSVSTPSASFEHNNTSENCQSRNVELCETPSTSDTKSDSATGGESSGQTTVSQEPSGCSNQRPTEDLTVRVERLTKKLEERREEKRKEEEQREIKKEIERRKTGKEMLDYKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLAKQAEMEIKRETSTKERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNFSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTTSMVHSSSGDFWTLLGTVLYPFLAIWRLISNFLFSNPPPAQTSVRAASLETSNLASSSNSEKREPVRKRVLEKRGEDFKKEGKIYRLRTQDDGEDENNTWNGNSTQQM", "length": 508, "header": "sp|Q3ZBU9-1|UBXN4_BOVIN Isoform 1 of UBX domain-containing protein 4 OS=Bos taurus OX=9913 GN=UBXN4 PE=2 SV=2 CANONICAL=Q3ZBU9-1" }, "locus": { "chromosome": "2", "start_pos": 61617550, "end_pos": 61588167, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020184.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020184.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020184.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020184.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 133, "start_aa": "Thr", "end_pos": 133, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr133", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 489, "end_pos": 489, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBU9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU9" } ], "site_lbl": "Thr489" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:536181", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536181", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z4X3-1", "protein_name": "UBX domain-containing protein 4", "gene_name": "UBXN4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MMWFGGSIPAAIAAAKQQSSVFVVFVSGEDEQSTEMAARWEDAQVTEAASDGFVAIKIDTKSEACLQFSQIYPVVCVPSSFFIGDNGIPLEVIAGSVSVEELVTRIHKVKQMHAEKGRPLENPCQSSAPCPSSPSDGAPENVQSTAEDPRGSPESVMSEPRPSDALADGANSGQASQEATQSSDEQVSNAQPANDLALKVERITKKLEERREEKRKEEEQKEIKKEIERRKTGKEMLEYKRRQEEELTKRMLEERNREKAEEKAARERIRQQIALDRAERAARFAKSKEEAEAAKAAALQAKQAEIEARKEASQKERSAIARIQFRLPDGSSFTNQFPSEARLEEARQFAAQTVGNAYGNFSLATMFPRREFTKEDYGKKLLELELAPSASVVLLPAGRPATSVVQASGGDLWKFLGTILYPLLAVWRFISNFLFTSPPPSESTVRTVHQQDHSNPSNSNNVEQSRQTVRKRVTEKRGEDFKKEGKIYRLRTQDDGEDENNTWNGNSTQQM", "length": 511 }, "evidence": [ { "id": "Q3ZBU9", "url": "https://omabrowser.org/oma/group/Q3ZBU9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S0D8-1", "protein_name": "UBX domain-containing protein 4", "gene_name": "UBXN4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLWFQGAIPAAIASAKRSGAVFVVFVAGDDEQSTQMAASWEDDKVTEASSNNFVAIKIDTKSEACLQFSQIYPVVCVPSSFFIGDSGIPLEVIAGSVSADELVSRIHKVQQMHTLKGETSVANGSQSESSVSTPSNSSEHNNTSENCQSGNVELRKTPPTSPDKKSDSAAGGESSGHATVSQEPSGCSNQRPTEDLTVRVERLTKKLEERREEKRKEEEQREIKKEIERRKTGKEMLDYKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLAKQAEVEAKRDSSTRERSSVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNFSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTTSMVHSSSGDFWTLLGTVLYPFLAIWRLISNFLFSNPPAQTSVRTASVESSNLASASNSEKREPVRKRVLEKRGEDFKKEGKIYRLRTQDDGEDENNTWNGNSTQQM", "length": 508 }, "evidence": [ { "id": "Q3ZBU9", "url": "https://omabrowser.org/oma/group/Q3ZBU9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GZQ8-1", "protein_name": "UBX domain-containing protein 4", "gene_name": "Ubxn4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLWFQGAIPAAIASAKRSGAVFVVFVAGDDEQSTQMAASWEDEKVTEASSNNFVAIKIDTKSEACLQFSQIYPVVCIPSSFFIGDNGIPLEVIAGSVSADELVTRIHKVQQMHSSKGETVTNDNQSESSVSTPSASFEPNDICENTESRNPELCETPAAADTKSDTATGGECSSHDNPSQEPHGCSNQRPAEDLTVRVERLTKKLEERREEKRKEEEQREIKKEIERRKTGKEMLDYKRKQEEELTKRMLEERSREKAEDRAARERIKQQIALDRAERAARFAKTKEVEAAKAAALLARQAEAEVRRESSARDRSTVARIQFRLPDGSSFTNQFPSDALLEEARQFAAQTVGNTYGNFSLATMFPRREFTREDYKRKLLDLELAPSASVVLLPAGRPTTSIVHPSSGDIWTLLGTVLYPFLAIWRLISNFLFSNPPPAQTSVRATSSEPSNPASSNKSEKREPVRKRVLEKRGEDFKKEGKIYRLRTQDDGEDENNTWNGNSTQQM", "length": 506 }, "evidence": [ { "id": "Q3ZBU9", "url": "https://omabrowser.org/oma/group/Q3ZBU9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5HZY0-1", "protein_name": "UBX domain-containing protein 4", "gene_name": "Ubxn4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLWFQGAIPAAIASAKRSGAVFVVFVAGDDEQSTQMAASWEDEKVREASSDNFVAIKIDTKSEACLQFSQIYPVVCVPSSFFIGDSGIPLEVIAGSVSADELVTRIHKVQQMHSLKGETSVTNDKQSESSVSTPSASFEPDICESAESRNTELCETPTTSDPKSDTAAGGECAGHDSLSQEPPGCSNQRPAEDLTVRVERLTKKLEERREEKRKEEAQREIKKEIERRKTGKEMLDYKRKQEEELTKRMLEERSREKAEDRAARERIKQQIALDRAERAARFAKTKEAEAAKAAALLAKQAEAEVKRESSTRDRSTIARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNFSLATMFPRREFTREDYKRKLLDLELAPSASVVLLPAGRPATSIVPSSSGDIWTLLGTVLYPFLAIWRLISNFLFSNPPPAQTSARATSTEPSNSASSSKSEKREPVRKRVLEKRGEDFKKEGKIYRLRTQDDGEDENNTWNGNSTQQM", "length": 506 }, "evidence": [ { "id": "Q3ZBU9", "url": "https://omabrowser.org/oma/group/Q3ZBU9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VCH8-1", "protein_name": "UBX domain-containing protein 4", "gene_name": "Ubxn4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLWFQGAIPAAIASAKRSGAVFVVFVAGDDEQSIQMAASWEDEKVTQASSNNFVAIKIDTKSEACLQFSQIYPVVCVPSSFFIGDSGIPLEVIAGSVSADELVTRIHKVQQMHSSKGEASVTNDNQSESSVSTPSASFEPDVCENPESKNTELCETPATSDIKSDTATGGECTGHDSHSQEPHGCSNQRPAEDLTVRVERLTKKLEERREEKRKEEAQREIKKEIERRKTGKEMLDYKRKQEEELTKRMLEERSREKAEDRAARERIKQQIALDRAERAARFAKTKEAEAAKAAALLTKQAGTEVKRESTARDRSTIARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNFSLATMFPRREFTREDYKRRLLDLELAPSASVVLLPAGRPATSIVHSSSGDIWTLLGTVLYPFLAIWRLISNFLFSNPPPAQTSARATSTEPSNSASSSKSEKREPVRKRMLEKRGEDFKKEGKIYRLRTQDDGEDENNTWNGNSTQQM", "length": 506 }, "evidence": [ { "id": "Q3ZBU9", "url": "https://omabrowser.org/oma/group/Q3ZBU9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92575-1", "protein_name": "UBX domain-containing protein 4", "gene_name": "UBXN4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLWFQGAIPAAIATAKRSGAVFVVFVAGDDEQSTQMAASWEDDKVTEASSNSFVAIKIDTKSEACLQFSQIYPVVCVPSSFFIGDSGIPLEVIAGSVSADELVTRIHKVRQMHLLKSETSVANGSQSESSVSTPSASFEPNNTCENSQSRNAELCEIPPTSDTKSDTATGGESAGHATSSQEPSGCSDQRPAEDLNIRVERLTKKLEERREEKRKEEEQREIKKEIERRKTGKEMLDYKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLAKQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNFSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSSGDIWTLLGTVLYPFLAIWRLISNFLFSNPPPTQTSVRVTSSEPPNPASSSKSEKREPVRKRVLEKRGDDFKKEGKIYRLRTQDDGEDENNTWNGNSTQQM", "length": 508 }, "evidence": [ { "id": "Q3ZBU9", "url": "https://omabrowser.org/oma/group/Q3ZBU9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9ZW74-1", "protein_name": "Plant UBX domain-containing protein 11", "gene_name": "PUX11", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEALSSLTFKGSLPEAIFEAKGKKKLFVVYISGEDEESDKLNRLTWTDASVADSLSKYCILVHIQAGSVDATNFSAIYPYSSVPCIAAIGFSGTQVWRTEGFITAEDLASSLEKAWLGLHIQETTASIFSAALASQNSETPVSSASSVVLPPGSVPLDAAVASPSTASSVQPSETKSTVTSASTTENNDGTVAVKGKESAEPSNLCDTTKNQPAPSVDGTKANVEHEATETPLRVQAEKEPIRPTAPGTNDNTSRVRSSVDRKRKQGTVINEEDSGVGVSGRDINLTKSVDTKETMKPKDEGGEEEDGEKSKKASDVHLNIRLPDGSSLQEKFSVTSILRMVKDYVNSNQTIGLGAYDLAVPYPRKVYTDQDLDKSLSELRLFDRQALVVVPRKRATVYQRGTSYSESNNNTDPNSGGYFAYVRRVLSYANPFSYFGGGTANASSSVPERQTRPNTEVRNNLGQVGTSFQDPSEGRSNVRNRRPTTSRIGSNIHTLNHNEDEAPFGDGNAFWNGNSTQYGGGSGGDSNDRR", "length": 531 }, "evidence": [ { "id": "Q3ZBU9", "url": "https://omabrowser.org/oma/group/Q3ZBU9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBU9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU9" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBU9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU9" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBU9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "ERAD pathway", "id": "GO:0036503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBU9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU9" } ], "pmid": "" }, { "name": "response to unfolded protein", "id": "GO:0006986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006986", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBU9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" }, { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" }, { "start_pos": 359, "end_pos": 361, "annotation": "n_glycosylation_sequon" }, { "start_pos": 497, "end_pos": 499, "annotation": "n_glycosylation_sequon" }, { "start_pos": 503, "end_pos": 505, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBU9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 508, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBU9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBU9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBU9" }, { "id": "PRU00215", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00215" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBX", "eco_id": "ECO_0000255", "start_pos": 315, "end_pos": 393, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 133 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 489 ], "sequon_annotation_sites": [ { "start_pos": 123, "end_pos": 125 }, { "start_pos": 141, "end_pos": 143 }, { "start_pos": 142, "end_pos": 144 }, { "start_pos": 359, "end_pos": 361 }, { "start_pos": 497, "end_pos": 499 }, { "start_pos": 503, "end_pos": 505 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZC15-1", "uniprot_ac": "Q3ZC15", "uniprot_id": "RCAN2_BOVIN", "mass": { "chemical_mass": 21938.0, "monoisotopic_mass": 21938.0 }, "refseq": { "ac": 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"https://www.ebi.ac.uk/interpro/entry/IPR034919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525636", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525636", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ESGCHFD", "url": "https://omabrowser.org/oma/group/ESGCHFD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZC15", "url": "https://www.orthodb.org/?gene=Q3ZC15", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10300", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10300", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10300:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10300:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04847", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04847", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015632", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015632", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SVQ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVQ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVQ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVQ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC15", "url": "https://www.uniprot.org/uniprotkb/Q3ZC15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC15-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC15-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC15-2", "url": "https://www.uniprot.org/uniprotkb/Q3ZC15-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPAPSMDCDVSTLVACVVDVEVFTNQEVKEKFEGLFRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPASPPVGWQPISDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDIEEEEDPKTSPKPKIIQTRRPGPPPSVSN", "length": 197, "header": "sp|Q3ZC15-1|RCAN2_BOVIN Isoform 1 of Calcipressin-2 OS=Bos taurus OX=9913 GN=RCAN2 PE=2 SV=1 CANONICAL=Q3ZC15-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVQ4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC15/entry#A0AAA9SVQ4-1", "sequence": { "sequence": "MMAIFTYSENRMRGDSYFIGMRSLGQQGHIPEDGGLFLLCCIDRDWAVTQCFTEEAFQAITDFTDLPNSLFACNVHQSVFEGEESKEKFEGLFRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPASPPVGWQPISDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDIEEEEDPKTSPKPKIIQTRRPGPPPSVSN", "length": 254, "header": "tr|A0AAA9SVQ4-1|RCAN2_BOVIN Computationally mapped isoform of Calcipressin-2 OS=Bos taurus OX=9913 GN=RCAN2 PE=2 SV=1 CANONICAL=Q3ZC15-1" }, "locus": { "chromosome": "23", "start_pos": 19733896, "end_pos": 19455307, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094302.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094302.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088275.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088275.1" } ] } }, { "isoform_ac": "Q3ZC15-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC15/entry#Q3ZC15-1", "sequence": { "sequence": "MPAPSMDCDVSTLVACVVDVEVFTNQEVKEKFEGLFRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPASPPVGWQPISDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDIEEEEDPKTSPKPKIIQTRRPGPPPSVSN", "length": 197, "header": "sp|Q3ZC15-1|RCAN2_BOVIN Isoform 1 of Calcipressin-2 OS=Bos taurus OX=9913 GN=RCAN2 PE=2 SV=1 CANONICAL=Q3ZC15-1" }, "locus": { "chromosome": "23", "start_pos": 19555030, "end_pos": 19455307, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046658.4", "url": "https://www.ensembl.org/id/ENSBTAT00000046658.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043934.3", "url": "https://www.ensembl.org/id/ENSBTAP00000043934.3" } ] } }, { "isoform_ac": "Q3ZC15-2", "url": "https://www.uniprot.org/uniprotkb/Q3ZC15/entry#Q3ZC15-2", "sequence": { "sequence": "MRGDSYFIGMRSLGQQGHIPEDGGLFLLCCIDRDWAVTQCFTEEAFQAITDFTDLPNSLFACNVHQSVFEGEESKEKFEGLFRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPASPPVGWQPISDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDIEEEEDPKTSPKPKIIQTRRPGPPPSVSN", "length": 243, "header": "sp|Q3ZC15-2|RCAN2_BOVIN Isoform 2 of Calcipressin-2 OS=Bos taurus OX=9913 GN=RCAN2 PE=2 SV=1 CANONICAL=Q3ZC15-1" }, "locus": { "chromosome": "23", "start_pos": 19685336, "end_pos": 19455307, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053783.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053783.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048923.2", "url": "https://www.ensembl.org/id/ENSBTAP00000048923.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 157, "start_aa": "Thr", "end_pos": 157, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr157", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 167, "end_pos": 167, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC15", "url": "https://www.uniprot.org/uniprotkb/Q3ZC15" } ], "site_lbl": "Ser167" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC15", "url": "https://www.uniprot.org/uniprotkb/Q3ZC15" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:525636", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525636", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1V5F5-1", "protein_name": "Calcipressin-2", "gene_name": "RCAN2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPAPSMDCDASTLVACVVDVEVFTNQEVKEKFEGLFRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPASPPVGWQPISDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDIEEEEDPKTSPKPKIIQTRRPGPPPSVSN", "length": 197 }, "evidence": [ { "id": "Q3ZC15", "url": "https://omabrowser.org/oma/group/Q3ZC15/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q14206-1", "protein_name": "Calcipressin-2", "gene_name": "RCAN2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPAPSMDCDVSTLVACVVDVEVFTNQEVKEKFEGLFRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPINDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDIEEEEDPKTSPKPKIIQTRRPGLPPSVSN", "length": 197 }, "evidence": [ { "id": "Q3ZC15", "url": "https://omabrowser.org/oma/group/Q3ZC15/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8CH27-1", "protein_name": "Calcipressin-2", "gene_name": "Rcan2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPAPSMDCDVSTLVACVVDVEVFTNQEVKEKFEGLFRTYDECVTFQLFKSFRRVRINFSHPKAAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWKPISDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDLEEEEDPKTSPKPKIIQTRRPGLPPSVSN", "length": 197 }, "evidence": [ { "id": "Q3ZC15", "url": "https://omabrowser.org/oma/group/Q3ZC15/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9JHG2-1", "protein_name": "Calcipressin-2", "gene_name": "Rcan2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPAPSMDCDVSTLVACVVDVEVFTNQEVKEKFEGLFRTYDECVTFQLFKSFRRVRINFSHPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWKPISDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDMEEEEDPKTSPKPKIIQTRRPGLPPSVSN", "length": 197 }, "evidence": [ { "id": "Q3ZC15", "url": "https://omabrowser.org/oma/group/Q3ZC15/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, 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"table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBJ0-1", "uniprot_ac": "Q3ZBJ0", "uniprot_id": "ENY2_BOVIN", "mass": { "chemical_mass": 11529.0, "monoisotopic_mass": 11529.0 }, "refseq": { "ac": "NP_001029919", "name": "transcription and mRNA export factor ENY2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029919" }, "gene_names": [ { "name": "ENY2", "type": "recommended", "evidence": [ { "id": "Q3ZBJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ0" } ] }, { "name": "ENY2", "type": "synonym", "evidence": [ { "id": "NP_001029919", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029919" } ] } ], "protein_names": [ { "name": "Transcription and mRNA export factor ENY2", "type": "recommended", "evidence": [ { "id": "Q3ZBJ0", "database": "UniProtKB", "url": 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both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). 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}, "evidence": [ { "id": "Q3ZBJ0", "url": "https://omabrowser.org/oma/group/Q3ZBJ0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2M774-1", "protein_name": "Transcription and mRNA export factor ENY2", "gene_name": "Eny2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVVSKMNKDAQMRAAINQKLIETGERERLKELLRAKLIECGWKDQLKAHCKEVIKEKGLEHVTVDDLVAEITPKGRALVPDSVKKELLQRIRTFLAQHASL", "length": 101 }, "evidence": [ { "id": "Q3ZBJ0", "url": "https://omabrowser.org/oma/group/Q3ZBJ0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZWF5-1", "protein_name": "Transcription and mRNA export factor ENY2", "gene_name": "Eny2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVSKMNKDAQMRAAINQKLIETGERERLKELLRAKLIECGWKDQLKAHCKEVIKEKGLEHVTVDDLVAEITPKGRALVPDSVKKELLQRIRTFLAQHASL", "length": 100 }, "evidence": [ { "id": "Q3ZBJ0", "url": "https://omabrowser.org/oma/group/Q3ZBJ0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6DH42-1", "protein_name": "Transcription and mRNA export factor ENY2", "gene_name": "eny2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSKESQMRAAINQKLIEMGERERLKELLRAKLIECGWRDQLKALCKEVIKEKGIENVTVEDLVAGVTPKGRALVPDSVKKELLQRIRAFLAQHST", "length": 95 }, "evidence": [ { "id": "Q3ZBJ0", "url": "https://omabrowser.org/oma/group/Q3ZBJ0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6NQ54-1", "protein_name": "Transcription and mRNA export factor ENY2", "gene_name": "ENY2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MKHSVNRPPTPDEDDVADGFEKDKVTLREIINVKLVESGEKENLMELVRDRLVECGWKDEMRIACREHVKKKGRKDVTVDELIRVITPKGRASVPDSVKAELLNRIQNFIVSAAL", "length": 115 }, "evidence": [ { "id": "Q3ZBJ0", "url": 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Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_991358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991358" }, { "database": "PubMed", "id": "20682045", "url": "https://glygen.org/publication/PubMed/20682045" } ] }, { "annotation": "Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY56#function" }, { "database": "UniProtKB", "id": "RU363059", "url": "https://www.uniprot.org/uniprotkb/RU363059#function" }, { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4#function" }, { "database": "UniProtKB", "id": "Q9BUN8", "url": "https://www.uniprot.org/uniprotkb/Q9BUN8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DERL1", "url": "https://www.uniprot.org/uniprotkb/Q71SS4", "locus": { "chromosome": "14", "start_pos": 16738151, "end_pos": 16714564, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020693", "url": "https://www.ensembl.org/id/ENSBTAG00000020693" } ] } } ], "crossref": [ { "id": "Q71SS4", "url": "https://alphafold.ebi.ac.uk/entry/Q71SS4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020693", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020693", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "404121", "url": "https://www.ncbi.nlm.nih.gov/gene/404121", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:404121", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404121", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LWRCVTS", "url": "https://omabrowser.org/oma/group/LWRCVTS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q71SS4", "url": "https://www.orthodb.org/?gene=Q71SS4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11009", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11009", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04511", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04511", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-382556", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-532668", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-532668", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9931269", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931269", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_991358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991358", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SY56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY56-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q71SS4-1", "url": "https://www.uniprot.org/uniprotkb/Q71SS4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDIGDWFRSIPTITRYWFAATVAVPLVGKLGLISPAYFFLWPEAFLYRFQIWRPITATFYFPVGPGTGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDMQLLMIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGDQ", "length": 251, "header": "sp|Q71SS4-1|DERL1_BOVIN Isoform 1 of Derlin-1 OS=Bos taurus OX=9913 GN=DERL1 PE=2 SV=1 CANONICAL=Q71SS4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SY56-1", "url": "https://www.uniprot.org/uniprotkb/Q71SS4/entry#A0AAA9SY56-1", "sequence": { "sequence": "MSDIGDWFRSIPTITRYWFAATVAVPLVGKLGLISPAYFFLWPEAFLYRFQACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGDQ", "length": 151, "header": "tr|A0AAA9SY56-1|DERL1_BOVIN Computationally mapped isoform of Derlin-1 OS=Bos taurus OX=9913 GN=DERL1 PE=2 SV=1 CANONICAL=Q71SS4-1" }, "locus": { "chromosome": "14", "start_pos": 16736483, "end_pos": 16714759, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112133.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112133.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090294.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090294.1" } ] } }, { "isoform_ac": "Q71SS4-1", "url": "https://www.uniprot.org/uniprotkb/Q71SS4/entry#Q71SS4-1", "sequence": { "sequence": "MSDIGDWFRSIPTITRYWFAATVAVPLVGKLGLISPAYFFLWPEAFLYRFQIWRPITATFYFPVGPGTGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDMQLLMIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGDQ", "length": 251, "header": "sp|Q71SS4-1|DERL1_BOVIN Isoform 1 of Derlin-1 OS=Bos taurus OX=9913 GN=DERL1 PE=2 SV=1 CANONICAL=Q71SS4-1" }, "locus": { "chromosome": "14", "start_pos": 16736483, "end_pos": 16714759, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079315.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079315.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070517.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070517.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 201, "end_pos": 201, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "site_lbl": "Ser201" }, { "start_pos": 202, "end_pos": 202, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "site_lbl": "Thr202" }, { "start_pos": 226, "end_pos": 226, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "site_lbl": "Ser226" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "Molecular characterization and expression of DERL1 in bovine ovarian follicles and corpora lutea.", "journal": "Reproductive biology and endocrinology : RB&E", "date": "2010-08-03", "authors": "Ndiaye Kalidou, Lussier Jacques G, Pate Joy L", "evidence": [ { "database": "RefSeq", "id": "NP_991358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991358" } ], "reference": [ { "type": "PubMed", "id": "20682045", "url": "https://glygen.org/publication/PubMed/20682045" } ] } ], "pathway": [ { "id": "bta:404121", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404121", "resource": "KEGG Pathway" }, { "id": "R-BTA-382556", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-382556", "resource": "Reactome", "description": "ABC-family protein mediated transport" }, { "id": "R-BTA-532668", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-532668", "resource": "Reactome", "description": "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" }, { "id": "R-BTA-9931269", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931269", "resource": "Reactome", "description": "AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BBB9-1", "protein_name": "Derlin", "gene_name": "DERL1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYFFLWPEAFLYRFQACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGDQ", "length": 151 }, "evidence": [ { "id": "Q71SS4", "url": "https://omabrowser.org/oma/group/Q71SS4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0ABK0LU34-1", "protein_name": "Derlin", "gene_name": "Derl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSDIGDWFRSIPAITRYWFAATVAVPLIGKLGIISPAYFFLWPEAFLYRFQIWRPFTATFYFPVGPGTGFLYLVNLYFLYQYSTRLEAGAFDGRPADYLFMLLFNWICIVITGLAMDMQLLMIPLIMSVLYVWAQLNRDLIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGLSLRHLRTWERKTALPERHGPHRTQSSFLRTTWSSKWMLWEVHVVVVIQASCKPLSSHLLRGPETTSQQDACRSP", "length": 312 }, "evidence": [ { "id": "Q71SS4", "url": "https://omabrowser.org/oma/group/Q71SS4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1Q4W3-1", "protein_name": "Derlin", "gene_name": "derl1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSDIGDWFKNIPFITRYWFAGSIAVPLIGKLGLIGPMYLVLWPEAFFHKFQIWRPITATLYFPVGPGTGFLYLVNLYFLYQYSSRLETGAFDGRPADYMFMLLFNWICIVITGLMMDMQLLMIPLIMSVLYVWAQLNRDTIVSFWFGTRFKACYLPWVILGFNYIIGGSVVNELIGNLVGHLYFFLMFKYPMDLGGRSFLSTPQFLYQMFPNRRGGVSGFGVPPSRRPMPQEQAGGGGGGGGGGGGGGRHNWGQGFRLGDD", "length": 261 }, "evidence": [ { "id": "Q71SS4", "url": "https://omabrowser.org/oma/group/Q71SS4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q99J56-1", "protein_name": "Derlin-1", "gene_name": "Derl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDIGDWFRSIPAITRYWFAATVAVPLIGKLGIISPAYFFLWPEAFLYRFQIWRPFTATFYFPVGPGTGFLYLVNLYFLYQYSTRLEAGAFDGRPADYLFMLLFNWICIVITGLAMDMQLLMIPLIMSVLYVWAQLNRDLIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGDQ", "length": 251 }, "evidence": [ { "id": "Q71SS4", "url": "https://omabrowser.org/oma/group/Q71SS4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BUN8-1", "protein_name": "Derlin-1", "gene_name": "DERL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQIWRPITATFYFPVGPGTGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDMQLLMIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGDQ", "length": 251 }, "evidence": [ { "id": "Q71SS4", "url": "https://omabrowser.org/oma/group/Q71SS4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VQ57-1", "protein_name": "Derlin-1", "gene_name": "Der-1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDAGVWYRSLPRFTRYWLTATVVLSMLCRFDVIPLHWLHLDRSAVFSKLQLWRCMTSLFVFPISSNTAFHFLINCFFIVQYSSKLEKDQYSRSPADYLYLLIVSAVLANIGGMIFNVYFLMDTLVLAITYIWCQLNKDVTVSFWFGTRFKAMYLPWVLAAFEFIFHFSLASLVGIFVGHVYYFFKFQYSQDLGGTPLLETPQFLKRLVPDVSGGFGGFGLPPESRAPPRQATESPWGRGMTLGRN", "length": 245 }, "evidence": [ { "id": "Q71SS4", "url": "https://omabrowser.org/oma/group/Q71SS4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "Derlin-1-VIMP complex", "id": "GO:0036502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036502", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" }, { "name": "Derlin-1 retrotranslocation complex", "id": "GO:0036513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036513", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" }, { "name": "endoplasmic reticulum quality control compartment", "id": "GO:0044322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044322", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "signal recognition particle binding", "id": "GO:0005047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005047", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" }, { "name": "ATPase binding", "id": "GO:0051117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051117", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" }, { "name": "ubiquitin-specific protease binding", "id": "GO:1990381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990381", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" }, { "name": "MHC class I protein binding", "id": "GO:0042288", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042288", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" }, { "name": "positive regulation of protein ubiquitination", "id": "GO:0031398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031398", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" }, { "name": "endoplasmic reticulum unfolded protein response", "id": "GO:0030968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030968", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" }, { "name": "ERAD pathway", "id": "GO:0036503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" }, { "name": "protein destabilization", "id": "GO:0031648", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031648", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" }, { "name": "cellular response to misfolded protein", "id": "GO:0071218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071218", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" }, { "name": "retrograde protein transport, ER to cytosol", "id": "GO:0030970", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030970", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" }, { "name": "response to stress", "id": "GO:0006950", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006950", "evidence": [ { "database": "UniProtKB", "id": "Q71SS4", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q71SS4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 251, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q71SS4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q71SS4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q71SS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q71SS4" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "SHP-box", "eco_id": "ECO_0000250", "start_pos": 241, "end_pos": 248, "start_aa": "Asn", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 201, 202, 226 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": 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"table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5BIR6-1", "uniprot_ac": "Q5BIR6", "uniprot_id": "MED17_BOVIN", "mass": { "chemical_mass": 72737.0, "monoisotopic_mass": 72737.0 }, "refseq": { "ac": "NP_001029902", "name": "mediator of RNA polymerase II transcription subunit 17", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029902" }, "gene_names": [ { "name": "MED17", "type": "recommended", "evidence": [ { "id": "Q5BIR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6" } ] }, { "name": "CRSP6", "type": "synonym", "evidence": [ { "id": "NP_001029902", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029902" }, { "id": "Q5BIR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6" } ] }, { "name": "MED17", "type": "synonym", "evidence": [ { "id": "NP_001029902", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029902" } ] } ], "protein_names": [ { "name": "Mediator of RNA polymerase II transcription subunit 17", "type": "recommended", "evidence": [ { "id": "Q5BIR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6/entry#names_and_taxonomy" } ] }, { "name": "CRSP complex subunit 6", "type": "synonym", "evidence": [ { "id": "NP_001029902", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029902" }, { "id": "Q5BIR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6/entry#names_and_taxonomy" } ] }, { "name": "Cofactor required for Sp1 transcriptional activation subunit 6", "type": "synonym", "evidence": [ { "id": "Q5BIR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6/entry#names_and_taxonomy" } ] }, { "name": "Mediator complex subunit 17", "type": "synonym", "evidence": [ { "id": "Q5BIR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6/entry#names_and_taxonomy" } ] }, { "name": "cofactor required for Sp1 transcriptional activation subunit 6", "type": "synonym", "evidence": [ { "id": "NP_001029902", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029902" } ] }, { "name": "cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa", "type": "synonym", "evidence": [ { "id": "NP_001029902", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029902" } ] }, { "name": "mediator of RNA polymerase II transcription subunit 17", "type": "synonym", "evidence": [ { "id": "NP_001029902", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029902" } ] } ], "function": [ { "annotation": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5BIR6", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6#function" }, { "database": "UniProtKB", "id": "A0AAA9TC09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC09#function" }, { "database": "UniProtKB", "id": "RU364140", "url": "https://www.uniprot.org/uniprotkb/RU364140#function" }, { "database": "UniProtKB", "id": "ARBA00025687", "url": "https://www.uniprot.org/uniprotkb/ARBA00025687#function" }, { "database": "UniProtKB", "id": "A0AAA9TYF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYF5#function" }, { "database": "UniProtKB", "id": "A0AAA9SZX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZX3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5BIR6", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MED17", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6", "locus": { "chromosome": "29", "start_pos": 1013693, "end_pos": 1043535, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003552", "url": "https://www.ensembl.org/id/ENSBTAG00000003552" } ] } } ], "crossref": [ { "id": "Q5BIR6", "url": "https://alphafold.ebi.ac.uk/entry/Q5BIR6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003552", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003552", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "541303", "url": "https://www.ncbi.nlm.nih.gov/gene/541303", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019313", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019313", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541303", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541303", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HMSYEPQ", "url": "https://omabrowser.org/oma/group/HMSYEPQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5BIR6", "url": "https://www.orthodb.org/?gene=Q5BIR6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13114", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13114", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13114:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13114:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10156", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10156", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9841922", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9841922", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029902", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SZX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZX3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC09-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYF5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BIR6", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BIR6-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGAEGDAQDWAGAGSSADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIRVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSPKSATEKQSPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINSIQSSEGLLEKIIKQAKHIFLRSRTAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSHEGQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPVESIGNASAITVASPNGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWNHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL", "length": 651, "header": "sp|Q5BIR6-1|MED17_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 17 OS=Bos taurus OX=9913 GN=MED17 PE=2 SV=1 CANONICAL=Q5BIR6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZX3-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6/entry#A0AAA9SZX3-1", "sequence": { "sequence": "MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGAEGDAQDWAGAGSSADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIRVSIQKQAPDIGDLGTVNLFKRPLPKSKPGLQLSISLCHSSNDKKSPKSATEKQSPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINSIQSSEGLLEKIIKQAKHIFLRSRTAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSHEGQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPVESIGNASAITVASPNGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWNHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL", "length": 600, "header": "tr|A0AAA9SZX3-1|MED17_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 17 OS=Bos taurus OX=9913 GN=MED17 PE=2 SV=1 CANONICAL=Q5BIR6-1" }, "locus": { "chromosome": "29", "start_pos": 1043421, "end_pos": 1014782, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133682.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133682.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088933.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088933.1" } ] } }, { "isoform_ac": "A0AAA9TC09-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6/entry#A0AAA9TC09-1", "sequence": { "sequence": "MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGAEGDAQDWAGAGSSADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIRVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSPKSATEKQSPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINSIQSSEGLLEKIIKQAKHIFLRSRTAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSHEGQELQDFLLSQFVMALKVAARLWFSFPVTSVKTFQKVMFYKIASGIIFVGHSKKFSGIKWKAETLFIKWSCLCLHLVLVYCDFFFWTSFQIFFPQRSFQKLSGMFADQQ", "length": 626, "header": "tr|A0AAA9TC09-1|MED17_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 17 OS=Bos taurus OX=9913 GN=MED17 PE=2 SV=1 CANONICAL=Q5BIR6-1" }, "locus": { "chromosome": "29", "start_pos": 1043421, "end_pos": 1014697, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134954.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134954.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095581.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095581.1" } ] } }, { "isoform_ac": "A0AAA9TYF5-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6/entry#A0AAA9TYF5-1", "sequence": { "sequence": "MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGAEGDAQDWAGAGSSADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIRVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSPKSATEKQSPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINSIQSSEGLLEKIIKQAKHIFLRSRSIQLQLNIGVEQIRVVHRDGRVITLSHEGQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPVESIGNASAITVASPNGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWNHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL", "length": 605, "header": "tr|A0AAA9TYF5-1|MED17_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 17 OS=Bos taurus OX=9913 GN=MED17 PE=2 SV=1 CANONICAL=Q5BIR6-1" }, "locus": { "chromosome": "29", "start_pos": 1043421, "end_pos": 1014782, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121033.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121033.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102258.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102258.1" } ] } }, { "isoform_ac": "Q5BIR6-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6/entry#Q5BIR6-1", "sequence": { "sequence": "MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGAEGDAQDWAGAGSSADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIRVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSPKSATEKQSPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINSIQSSEGLLEKIIKQAKHIFLRSRTAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSHEGQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPVESIGNASAITVASPNGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWNHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL", "length": 651, "header": "sp|Q5BIR6-1|MED17_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 17 OS=Bos taurus OX=9913 GN=MED17 PE=2 SV=1 CANONICAL=Q5BIR6-1" }, "locus": { "chromosome": "29", "start_pos": 1043421, "end_pos": 1014782, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004623.5", "url": "https://www.ensembl.org/id/ENSBTAT00000004623.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004623.4", "url": "https://www.ensembl.org/id/ENSBTAP00000004623.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5BIR6", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:541303", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541303", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" }, { "id": "R-BTA-9841922", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9841922", "resource": "Reactome", "description": "MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis" } ], "orthologs": [ { "uniprot_canonical_ac": "D4ABU0-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 17", "gene_name": "Med17", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGPDGDAPDWAGAGADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQSPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPSLQLSISLCHSSDDKKSQKCAPEKPGQEGHLYVLEHNLHLLIREFHKQTLSSIVMPHPASAPFGHKRMRLSGPQAFDKNEINSIQSTEGLLEKIIKQAKHIFLRSRTAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQVRVVHRDGRVITLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWSHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL", "length": 649 }, "evidence": [ { "id": "Q5BIR6", "url": "https://omabrowser.org/oma/group/Q5BIR6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NY10-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 17", "gene_name": "MED17", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGVPAVRISIESACEKQVQEVGLDGSETYLQPLSMSQNLARLAQRIDFSQGSGSEEDEPGSAGRAWAEPSEAEDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVKDKKFMTLDPVVQDPPPPKQNPQFLQLISKKKSLAGAAQILLKGAERLSKSVAENQENKRQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFLHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPMPKSKPGTPHWQTKLETAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPGLQLSISLCHSSNDKKSQKSASEKQNPEDHLYVLEHNLHQLIRECHKQTLSSVVMPHPASAPFGHKRMRLAGPQAFDKNEISSLQTNEGLLEKIIKQAKHIFLRRRTARTIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWHVLSFSNHVGLGPVESIGNASAITVASPNGDYAISVRNGPESGSKVMVQFPRSQCKDLPKGDVLQDNKWNHLRGPFKEVQWNKMEGRNFVYKMELLMAALTPC", "length": 643 }, "evidence": [ { "id": "Q5BIR6", "url": "https://omabrowser.org/oma/group/Q5BIR6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HSP6-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 17", "gene_name": "Med17", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEDEAAGPDGDAQDWAGAGAEQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQSPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSQKCATEKPGPEDHLYVLEHNLHLLIREFHKQTLSSIVMPHPASAPFGHKRMRLSGPQAFDKNEINSIQSTEGLLEKIIKQAKHIFLRSRTAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQVRVVHRDGRVITLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWSHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL", "length": 649 }, "evidence": [ { "id": "Q5BIR6", "url": "https://omabrowser.org/oma/group/Q5BIR6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8VCD5-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 17", "gene_name": "Med17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGPDGDAPDWGGAGADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQSPQTLQLISKKKSLAGAAQILLKGAERLTKSVAENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPSLQLSISLCHSSDDKKSQKCAAEKPGQEDHLYVLEHNLHLLIREFHKQTLSSIVMPHPASAPFGHKRMRLSGPQAFDKNEINSIQSTEGLLEKIIKQAKHIFLRSRTAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQVRVVHRDGRVIMLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWSHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL", "length": 649 }, "evidence": [ { "id": "Q5BIR6", "url": "https://omabrowser.org/oma/group/Q5BIR6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NVC6-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 17", "gene_name": "MED17", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGVRAVRISIESACEKQVHEVGLDGTETYLPPLSMSQNLARLAQRIDFSQGSGSEEEEAAGTEGDAQEWPGAGSSADQDDEEGVVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDLDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQVPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSQKFATEKQCPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINSLQSSEGLLEKIIKQAKHIFLRSRAAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSYQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDNKWSHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL", "length": 651 }, "evidence": [ { "id": "Q5BIR6", "url": "https://omabrowser.org/oma/group/Q5BIR6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VEC1-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 17", "gene_name": "MED17", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSNSVNISVETTCENQIREIGYDGTELYQPPPTLSESLAKCAARIDFSKTSLDDLKKEEKSAAAAADEDKDATQFQESLWPWDAVRNKLKDALTEICVLSDVISIAKDKRYLVLDPLLEEADDTKPIVQVYSRKKAISQAAQVLLSGAERLRNAHSEQRNRNVSDFHIELLRLRQNWRLKKVSNAIIGDLSYRTAGSKFGMSGTFEVTKAEETGDEDTASSSNSSSSVSGNNGMQLKASSALRVIVPAELQGVAYIKVITQKDQEDLCTAQLNLMGHGPNITAQVGVWQKTLEFAQNVLFCKELFAQLAREAIQLQAPIPHVVIGNQIRATLLPNIQLIISLCHSTTFDSSQPAPINDHDHVLEHSLHQLLREVHYKNSHHPFPHPASAPLGPTKKRMLAGPMAADRETLLDMTKSQTILEQIIAQAQHIFMRKRTQYVLDTLARDVKDPQIVSHWNAMNSPTMSCVKINIVTHGYDAIGRTSLVIHVKERSLKCICRDGRVMRLSYEPQELRDLILCQINSHQISCLISLARCMSWTVLSNSNHLGIGKVEPLGNASSCLLASPNSDRMIAVQIRCDPQIDVKVYIARSPRQDFFPSPLVPEKLWENLGGTFKEVRFDKIEGKSFLNKMEFLMASLTSNTA", "length": 642 }, "evidence": [ { "id": "Q5BIR6", "url": "https://omabrowser.org/oma/group/Q5BIR6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of transcription initiation by RNA polymerase II", "id": "GO:0060261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060261", "evidence": [ { "database": "UniProtKB", "id": "Q5BIR6", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q5BIR6", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q5BIR6", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "Q5BIR6", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6" } ], "pmid": "" }, { "name": "nuclear thyroid hormone receptor binding", "id": "GO:0046966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046966", "evidence": [ { "database": "UniProtKB", "id": "Q5BIR6", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6" } ], "pmid": "" }, { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "Q5BIR6", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mediator complex", "id": "GO:0016592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "evidence": [ { "database": "UniProtKB", "id": "Q5BIR6", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6" } ], "pmid": "" }, { "name": "core mediator complex", "id": "GO:0070847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070847", "evidence": [ { "database": "UniProtKB", "id": "Q5BIR6", "url": "https://www.uniprot.org/uniprotkb/Q5BIR6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 565, "end_pos": 567, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5BIR6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 651, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5BIR6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5BIR6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 565, "end_pos": 567 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5BIM1-1", "uniprot_ac": "Q5BIM1", "uniprot_id": "TRI45_BOVIN", "mass": { "chemical_mass": 63754.0, "monoisotopic_mass": 63754.0 }, "refseq": { "ac": "NP_001014952", "name": "E3 ubiquitin-protein ligase TRIM45", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014952" }, "gene_names": [ { "name": "TRIM45", "type": "recommended", "evidence": [ { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1" } ] }, { "name": "TRIM45", "type": "synonym", "evidence": [ { "id": "NP_001014952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014952" } ] } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase TRIM45", "type": "recommended", "evidence": [ { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.27", "type": "synonym", "evidence": [ { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1/entry#names_and_taxonomy" } ] }, { "name": "E3 ubiquitin-protein ligase TRIM45", "type": "synonym", "evidence": [ { "id": "NP_001014952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014952" } ] }, { "name": "RING finger protein 99", "type": "synonym", "evidence": [ { "id": "NP_001014952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014952" }, { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1/entry#names_and_taxonomy" } ] }, { "name": "Tripartite motif-containing protein 45", "type": "synonym", "evidence": [ { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1/entry#names_and_taxonomy" } ] }, { "name": "tripartite motif-containing protein 45", "type": "synonym", "evidence": [ { "id": "NP_001014952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014952" } ] } ], "function": [ { "annotation": "E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response. Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response. May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q5BIM1", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1#function" }, { "database": "UniProtKB", "id": "Q9H8W5", "url": "https://www.uniprot.org/uniprotkb/Q9H8W5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5BIM1", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRIM45", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1", "locus": { "chromosome": "3", "start_pos": 26109125, "end_pos": 26099669, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001748", "url": "https://www.ensembl.org/id/ENSBTAG00000001748" } ] } } ], "crossref": [ { "id": "Q5BIM1", "url": "https://alphafold.ebi.ac.uk/entry/Q5BIM1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001748", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001748", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16588", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16588", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19785", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19785", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19809", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19809", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539091", "url": "https://www.ncbi.nlm.nih.gov/gene/539091", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001298", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001298", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003649", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003649", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017868", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017868", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539091", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539091", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TRCPLCM", "url": "https://omabrowser.org/oma/group/TRCPLCM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5BIM1", "url": "https://www.orthodb.org/?gene=Q5BIM1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR25462", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR25462", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR25462:SF291", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR25462:SF291", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00630", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00630", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00643", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00643", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13445", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13445", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014952", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T059", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T059", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T059-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T059-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BIM1", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BIM1-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEKRRPLLGFVGKLPSGTTAGNSGKTHCPLCMGLFKAPRLLPCLHTVCTTCLEQLEPFSVVDIRGGESDTSSEGSVFQELKPRALQPQIGILCPVCDAQVDLPMGGVKALTIDHLAMNDVMLESLRGEGQGLVCDLCSDREVEKRCQTCKANLCRFCCQAHRRQKKTTYHTMVDLKDLKGYSQIGKPILCPAHPAEELRLFCELCDRPVCRDCVVGEHREHPCDFTSNVIHKHGDSVRELLRGTQPHVEALEEALAQIKGTNSAVQERVKAVAADIRTFSEGYIKAIEEHRDKLLKQLEDIRVQKENSLQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKGVVVERLTKLNKVEYSAHPGVNEKISFSPKQKAGLCRGYEVYGAINTKEVDPAKCVLQGEDLHRAREKQPASFIVLCKDATGESMGRGGDNVQVTVIPNDKKDSPVKTMVHDNKDGTYYVSYTPKEPGTYTVLVCVKEQHVQGSPFTVTVRKRHRSHPGVFHCCTFCSSGGQKTARCACGGTMPGGYLGCGHGHKGHPGRPHWSCCGKFAEKSECTWAGGQSAPRSLLRTVAL", "length": 580, "header": "sp|Q5BIM1-1|TRI45_BOVIN Isoform 1 of E3 ubiquitin-protein ligase TRIM45 OS=Bos taurus OX=9913 GN=TRIM45 PE=2 SV=1 CANONICAL=Q5BIM1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T059-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1/entry#A0AAA9T059-1", "sequence": { "sequence": "MWNFQSLLDAGGVTLEGGGARSGDGRPSLTNCPGPFLILSTNVGNMAEKRRPLLGFVGKLPSGTTAGNSGKTHCPLCMGLFKAPRLLPCLHTVCTTCLEQLEPFSVVDIRGGESDTSSEGSVFQELKPRALQPQIGILCPVCDAQVDLPMGGVKALTIDHLAMNDVMLESLRGEGQGLVCDLCSDREVEKRCQTCKANLCRFCCQAHRRQKKTTYHTMVDLKDLKGYSQIGKPILCPAHPAEELRLFCELCDRPVCRDCVVGEHREHPCDFTSNVIHKHGDSVRELLRGTQPHVEALEEALAQIKGTNSAVQERVKAVAADIRTFSEGYIKAIEEHRDKLLKQLEDIRVQKENSLQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKGVVVERLTKLNKVEYSAHPGVNEKISFSPKQKAGLCRGYEVYGAINTKEVDPAKCVLQGEDLHRAREKQPASFIVLCKDATGESMGRGGDNVQVTVIPNDKKDSPVKTMVHDNKDGTYYVSYTPKEPGTYTVLVCVKEQHVQGSPFTVTVRKRHRSHPGVFHCCTFCSSGGQKTARCACGGTMPGGYLGCGHGHKGHPGRPHWSCCGKFAEKSECTWAGGQSAPRSLLRTVAL", "length": 625, "header": "tr|A0AAA9T059-1|TRI45_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase TRIM45 OS=Bos taurus OX=9913 GN=TRIM45 PE=2 SV=1 CANONICAL=Q5BIM1-1" }, "locus": { "chromosome": "3", "start_pos": 26109000, "end_pos": 26099702, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100859.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100859.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092125.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092125.1" } ] } }, { "isoform_ac": "Q5BIM1-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1/entry#Q5BIM1-1", "sequence": { "sequence": "MAEKRRPLLGFVGKLPSGTTAGNSGKTHCPLCMGLFKAPRLLPCLHTVCTTCLEQLEPFSVVDIRGGESDTSSEGSVFQELKPRALQPQIGILCPVCDAQVDLPMGGVKALTIDHLAMNDVMLESLRGEGQGLVCDLCSDREVEKRCQTCKANLCRFCCQAHRRQKKTTYHTMVDLKDLKGYSQIGKPILCPAHPAEELRLFCELCDRPVCRDCVVGEHREHPCDFTSNVIHKHGDSVRELLRGTQPHVEALEEALAQIKGTNSAVQERVKAVAADIRTFSEGYIKAIEEHRDKLLKQLEDIRVQKENSLQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKGVVVERLTKLNKVEYSAHPGVNEKISFSPKQKAGLCRGYEVYGAINTKEVDPAKCVLQGEDLHRAREKQPASFIVLCKDATGESMGRGGDNVQVTVIPNDKKDSPVKTMVHDNKDGTYYVSYTPKEPGTYTVLVCVKEQHVQGSPFTVTVRKRHRSHPGVFHCCTFCSSGGQKTARCACGGTMPGGYLGCGHGHKGHPGRPHWSCCGKFAEKSECTWAGGQSAPRSLLRTVAL", "length": 580, "header": "sp|Q5BIM1-1|TRI45_BOVIN Isoform 1 of E3 ubiquitin-protein ligase TRIM45 OS=Bos taurus OX=9913 GN=TRIM45 PE=2 SV=1 CANONICAL=Q5BIM1-1" }, "locus": { "chromosome": "3", "start_pos": 26109000, "end_pos": 26100399, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002293.5", "url": "https://www.ensembl.org/id/ENSBTAT00000002293.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002293.3", "url": "https://www.ensembl.org/id/ENSBTAP00000002293.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5BIM1", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:539091", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539091", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZIL2-1", "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "TRIM45", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAASRCPVCAEPCVEARLLPCLHSLCAPCLRRLGTLGEPGRAAAAFSVLCPLCDAEVALPPGGLGQLVPDYTALGRGGAAGTAGCDLCADGAAARRCQTCGAHLCLFCCQAHRRQKKTASHVVMELESTKDCSQAGKPFFCPSHPSEELGLFCEQCDQPVCQDCVAERHRQHPYDFTSNAVHRHGDSLRELLRSTQQRMSALEDVLGQTDGVGSAIRARAEAVATEICLFARGYVKAIEEHRDRLLKQLEDLKVQKENLLHLQKAQLQQLLLDMRTGVEFTERLLTSGSDLGILVTKGVVASRLAKLNSAAYSTHPSVDDSIQFSPQERAGQCHGYEVFGAVICKAVDPAKCTLQGEGLRSARQNELTGFTLLCSDTTGERMGRGGEAVVVTITHKDKKDCAVKPTVCDNGDGTYHISYSPEEPGLYAVCVYVKGQHVQGSPFIVMVKSQFRKHQGMFHCCTFCSSGGQKAARCACGGTMPGGYQGCGHGHKGHPGCPHWSCCGQVKMSSECLSGLPSDRSQRSLLRTVEL", "length": 531 }, "evidence": [ { "id": "Q5BIM1", "url": "https://omabrowser.org/oma/group/Q5BIM1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A7S9-1", "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "Trim45", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSENRKPLPGFVNKLQDASASGSSGKTHCPSCLRLFKVPRLLPCLHTVCTSCLERLDPFSVVDIRGGDSDTSSEGSIFQEPKSCSLKPQIGILCPVCDAQVDLPLGGVKALTVDHLAMNDVMLESLHGEGQGLVCDLCSDREVEKRCQTCKANLCHFCCQAHRRQKKTTDHTMVDLKDLKGYSRVGKPILCPSHPAEELRLFCELCDRPVCRDCVVGEHREHPYDFTSNVIHKHGDSVRELLRDTQPHVEALEDALAQIKSSNNALQERVEAVAADVRTFSEGYIRAIEEHRDKLLRQLDDIRVQKENSLQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILVTKGVVVERLRKLNKVEYSARPGVNHKICFSPQEKARCQGYEVYGAINTQEVDPAQCVLQGEDLHRAREKQTASFTLVCKDATGESMSRGGDNVRVEVVPKNKKDSPIRTVVQDNKDGSYRVSYTPKEPGVYTVWVGIREQQVQGSPFNVTVRRKHRPHPGVFHCCTFCSSGGQKTARCACGGTMPGGYLGCGHGHKGHPGRPHWSCCGKFIEKSECSYSTGQSAPRSLLRTVAL", "length": 579 }, "evidence": [ { "id": "Q5BIM1", "url": "https://omabrowser.org/oma/group/Q5BIM1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H907-1", "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "Trim45", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSENRKPLLGFVHKVPDANASGSSGKTHCPSCLGLFKAPRLLPCLHTVCTTCLEKLEPFSVVDIRGGDSDTSSERSIFQEPKSRSLQPQIGILCPVCDAQVDLPLGGVKALTIDHLAMNDVMLQSLRGEGQGLVCDLCSDREVEKRCQTCKANLCHFCCQAHRRQKKTMYHSMVDLKDLKGYSRVGKPILCPTHPAEELRLFCELCDQPVCRDCVVGEHREHPYDFTSNVIHKHGDSVRELLRGTQPHVEALEEALAQIKTMNSGLQERVEAVAADVRTFSEGYIKAIEEHRDKLLQQLDTIRVQKENSLQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKGVVVERLQKLNKVEYSSRPGVNDKICFSPREKAGQCRGYEVYGTINTKEVDPAKCVLQGEDLQRAREKQTTSFTLLCKDASGESLGRGGEDVQVAVVPKDKKDSPIRTVVQDNKDGSYHVSFTPKEAGVYIVWVCIREQHVQGSPFTVTVRRKHRSHPGVFHCCTFCSSGGQKTARCACGGTMPGGYLGCGHGHKGHPGRPHWSCCGKFIEKSDCTYTGGQSAPRSLLRTVAL", "length": 580 }, "evidence": [ { "id": "Q5BIM1", "url": "https://omabrowser.org/oma/group/Q5BIM1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6PFY8-1", "protein_name": "E3 ubiquitin-protein ligase TRIM45", "gene_name": "Trim45", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSEIRKPLLGFVHKLQDANASGSSGKTHCPTCLRLFKVPRLLPCLHTVCTTCLEKLDPFSVVDIRGGDSDTSSEGSVFQDPELCSLQPQIGILCPVCDAQVDLPLGGVKALTVDHLAMNDVLLENLRGEGQGLVCDLCSDREVEKRCQTCKANLCHFCCQAHRRQKKTTYHTMVDLKDLKGYSQVGKPILCPSHPAEELRLFCELCDRPVCRDCVVGEHREHPYDFTSNVIHKHGDSVRELLRDTQPHVEALEDALAQIKSVNNALQERVEAVAADVRTFSEGYIKAIEEHRDKLLQQLDDIRIQRETALQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKGVVVERLRKLNKVEYSARPGVNHKICFSPQEKAGQCQGYEVYGAINTQEVDPAQCVLQGEDLHRAREKQTASFTLFCKDASGQSMGRGGDNVHVEVVPKDKKDSPIRTVVQDNKDGSYRVSYTPKEPGIYTVWVCIREQHVQGSPFNVTVRRKHRPHPGVFHCCTFCSSGGQKAARCACGGTMPGGYLGCGHGHKGHPGRPHWSCCGKFIEKSECSFTSGQGAPRSLLRTVAL", "length": 580 }, "evidence": [ { "id": "Q5BIM1", "url": "https://omabrowser.org/oma/group/Q5BIM1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H8W5-1", "protein_name": "E3 ubiquitin-protein ligase TRIM45", "gene_name": "TRIM45", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSENRKPLLGFVSKLTSGTALGNSGKTHCPLCLGLFKAPRLLPCLHTVCTTCLEQLEPFSVVDIRGGDSDTSSEGSIFQELKPRSLQSQIGILCPVCDAQVDLPMGGVKALTIDHLAVNDVMLESLRGEGQGLVCDLCNDREVEKRCQTCKANLCHFCCQAHRRQKKTTYHTMVDLKDLKGYSRIGKPILCPVHPAEELRLFCEFCDRPVCQDCVVGEHREHPCDFTSNVIHKHGDSVWELLKGTQPHVEALEEALAQIHIINSALQKRVEAVAADVRTFSEGYIKAIEEHRDKLLKQLEDIRAQKENSLQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKRVVVERLRKLNKVQYSTRPGVNDKIRFCPQEKAGQCRGYEIYGTINTKEVDPAKCVLQGEDLHRAREKQTASFTLLCKDAAGEIMGRGGDNVQVAVVPKDKKDSPVRTMVQDNKDGTYYISYTPKEPGVYTVWVCIKEQHVQGSPFTVMVRRKHRPHSGVFHCCTFCSSGGQKTARCACGGTMPGGYLGCGHGHKGHPGHPHWSCCGKFNEKSECTWTGGQSAPRSLLRTVAL", "length": 580 }, "evidence": [ { "id": "Q5BIM1", "url": "https://omabrowser.org/oma/group/Q5BIM1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q5BIM1", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5BIM1", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5BIM1", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q5BIM1", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "Q5BIM1", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of inflammatory response", "id": "GO:0050728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050728", "evidence": [ { "database": "UniProtKB", "id": "Q5BIM1", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q5BIM1", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1" } ], "pmid": "" }, { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "Q5BIM1", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5BIM1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 580, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5BIM1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5BIM1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1#function" }, { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1" }, { "id": "PRU00024", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00024" } ], "binding_site_uniprot": 135, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 135, "end_pos": 135, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1#function" }, { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1" }, { "id": "PRU00024", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00024" } ], "binding_site_uniprot": 138, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 138, "end_pos": 138, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1#function" }, { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1" }, { "id": "PRU00024", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00024" } ], "binding_site_uniprot": 158, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 158, "end_pos": 158, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1#function" }, { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1" }, { "id": "PRU00024", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00024" } ], "binding_site_uniprot": 162, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 162, "end_pos": 162, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1#function" }, { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1" }, { "id": "PRU00024", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00024" } ], "binding_site_uniprot": 191, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 191, "end_pos": 191, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1#function" }, { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1" }, { "id": "PRU00024", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00024" } ], "binding_site_uniprot": 194, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 194, "end_pos": 194, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1#function" }, { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1" }, { "id": "PRU00024", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00024" } ], "binding_site_uniprot": 214, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 214, "end_pos": 214, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1#function" }, { "id": "Q5BIM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIM1" }, { "id": "PRU00024", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00024" } ], "binding_site_uniprot": 219, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "2", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 219, "end_pos": 219, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9Z2-1", "uniprot_ac": "Q5E9Z2", "uniprot_id": "HABP2_BOVIN", "mass": { "chemical_mass": 62441.0, "monoisotopic_mass": 62441.0 }, "refseq": { "ac": "NP_001014868", "name": "factor VII-activating protease precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014868" }, "gene_names": [ { "name": "HABP2", "type": "recommended", "evidence": [ { "id": "Q5E9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2" } ] }, { "name": "FSAP", "type": "synonym", "evidence": [ { "id": "NP_001014868", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014868" } ] }, { "name": "HABP2", "type": "synonym", "evidence": [ { "id": "NP_001014868", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014868" } ] }, { "name": "PHBP", "type": "synonym", "evidence": [ { "id": "NP_001014868", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014868" } ] } ], "protein_names": [ { "name": "Factor VII-activating protease", "type": "recommended", "evidence": [ { "id": "Q5E9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2/entry#names_and_taxonomy" } ] }, { "name": "3.4.21.-", "type": "synonym", "evidence": [ { "id": "Q5E9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2/entry#names_and_taxonomy" } ] }, { "name": "FSAP", "type": "synonym", "evidence": [ { "id": "Q5E9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2/entry#names_and_taxonomy" } ] }, { "name": "FVII activator", "type": "synonym", "evidence": [ { "id": "NP_001014868", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014868" }, { "id": "Q5E9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2/entry#names_and_taxonomy" } ] }, { "name": "Hepatocyte growth factor activator-like protein", "type": "synonym", "evidence": [ { "id": "Q5E9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2/entry#names_and_taxonomy" } ] }, { "name": "Hyaluronan-binding protein 2", "type": "synonym", "evidence": [ { "id": "Q5E9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2/entry#names_and_taxonomy" } ] }, { "name": "PHBP", "type": "synonym", "evidence": [ { "id": "Q5E9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2/entry#names_and_taxonomy" } ] }, { "name": "Plasma hyaluronan-binding protein", "type": "synonym", "evidence": [ { "id": "Q5E9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2/entry#names_and_taxonomy" } ] }, { "name": "factor VII-activating protease precursor", "type": "synonym", "evidence": [ { "id": "NP_001014868", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014868" } ] }, { "name": "factor VII-activating protease", "type": "synonym", "evidence": [ { "id": "NP_001014868", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014868" } ] }, { "name": "hepatocyte growth factor activator-like protein", "type": "synonym", "evidence": [ { "id": "NP_001014868", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014868" } ] }, { "name": "plasma hyaluronan-binding protein", "type": "synonym", "evidence": [ { "id": "NP_001014868", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014868" } ] } ], "function": [ { "annotation": "Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII. May function as a tumor suppressor negatively regulating cell proliferation and cell migration.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z2", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2#function" }, { "database": "UniProtKB", "id": "Q14520", "url": "https://www.uniprot.org/uniprotkb/Q14520#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z2", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HABP2", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2", "locus": { "chromosome": "26", "start_pos": 34062274, "end_pos": 34026815, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019322", "url": "https://www.ensembl.org/id/ENSBTAG00000019322" } ] } } ], "crossref": [ { "id": "Q5E9Z2", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9Z2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019322", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019322", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00108", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00108", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507993", "url": "https://www.ncbi.nlm.nih.gov/gene/507993", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012224", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012224", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050127", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050127", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507993", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507993", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GKTACGF", "url": "https://omabrowser.org/oma/group/GKTACGF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9Z2", "url": "https://www.orthodb.org/?gene=Q5E9Z2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24264", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24264", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24264:SF40", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24264:SF40", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00008", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00008", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00051", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00051", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014868", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T1Q8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1Q8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9Z2", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9Z2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFARMSDLHVLLLMVLAGKTAFGLSLLSFLTEPDPDWTPDQYEYSQEYNNQEENASSTTAYSDNPDWYYEEDDPCLSNPCTHGGDCLVSGATFTCRCPDPFSGNRCQNVQNKCKNNPCGRGDCLITQSPPYHRCACKHPYRGSDCSRVVPVCRPNPCQNGGTCSRQRRRSKFTCACPDQFKGKLCEIGPDDCYVDDGYSYRGRVSKTIHQHTCLYWNSHLLLQEKYNMFMEDAEAHGIGEHNFCRNPDGDKKPWCFIKVNNVKVKWEYCDVPACSALDVANPEGRPTEPLTKFPEFGSCGRTEIAEKKVKRIFGGFKSTAGKHPWQASLQTSLRLTVSTPQGHYCGGALIHPCWVLTAAHCTEIKTKYLKVVLGDQDLTKTEFHEQSFGVQKIFKYSHYIEIDDIPYNDIALLKLKPVDGHCALESKYVKTVCLPDGPFLSGTECYISGWGVTETGEGSRHLLDAKVKLISNTICNSRQLYDHSIDDNMICAGNLQKPGQDSCQGDSGGPLTCEKDGTSYIYGIVSWGLECGKRPGVYTQVTKFLTWIKATMEKEASF", "length": 558, "header": "sp|Q5E9Z2-1|HABP2_BOVIN Isoform 1 of Factor VII-activating protease OS=Bos taurus OX=9913 GN=HABP2 PE=2 SV=1 CANONICAL=Q5E9Z2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T1Q8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2/entry#A0AAA9T1Q8-1", "sequence": { "sequence": "HSQSFHDMRVLIMQKNFACFPLSLITGSVVPLLFGGRRQKSHERRGVSRLLFIANLDFCSCALDPCLSNPCTHGGDCLVSGATFTCRCPDPFSGNRCQNVQNKCKNNPCGRGDCLITQSPPYHRCACKHPYRGSDCSRVVPVCRPNPCQNGGTCSRQRRRSKFTCACPDQFKGKLCEIGPDDCYVDDGYSYRGRVSKTIHQHTCLYWNSHLLLQEKYNMFMEDAEAHGIGEHNFCRNPDGDKKPWCFIKVNNVKVKWEYCDVPACSALDVANPEGRPTEPLTKFPEFGSCGRTEIAEKKVKRIFGGFKSTAGKHPWQASLQTSLRLTVSTPQGHYCGGALIHPCWVLTAAHCTEIKTKYLKVVLGDQDLTKTEFHEQSFGVQKIFKYSHYIEIDDIPYNDIALLKLKPVDGHCALESKYVKTVCLPDGPFLSGTECYISGWGVTETGEGSRHLLDAKVKLISNTICNSRQLYDHSIDDNMICAGNLQKPGQDSCQGDSGGPLTCEKDGTSYIYGIVSWGLECGKRPGVYTQVTKFLTWIKATMEKEASF", "length": 549, "header": "tr|A0AAA9T1Q8-1|HABP2_BOVIN Computationally mapped isoform of Factor VII-activating protease OS=Bos taurus OX=9913 GN=HABP2 PE=2 SV=1 CANONICAL=Q5E9Z2-1" }, "locus": { "chromosome": "26", "start_pos": 34061122, "end_pos": 34048032, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102628.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102628.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090341.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090341.1" } ] } }, { "isoform_ac": "Q5E9Z2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2/entry#Q5E9Z2-1", "sequence": { "sequence": "MFARMSDLHVLLLMVLAGKTAFGLSLLSFLTEPDPDWTPDQYEYSQEYNNQEENASSTTAYSDNPDWYYEEDDPCLSNPCTHGGDCLVSGATFTCRCPDPFSGNRCQNVQNKCKNNPCGRGDCLITQSPPYHRCACKHPYRGSDCSRVVPVCRPNPCQNGGTCSRQRRRSKFTCACPDQFKGKLCEIGPDDCYVDDGYSYRGRVSKTIHQHTCLYWNSHLLLQEKYNMFMEDAEAHGIGEHNFCRNPDGDKKPWCFIKVNNVKVKWEYCDVPACSALDVANPEGRPTEPLTKFPEFGSCGRTEIAEKKVKRIFGGFKSTAGKHPWQASLQTSLRLTVSTPQGHYCGGALIHPCWVLTAAHCTEIKTKYLKVVLGDQDLTKTEFHEQSFGVQKIFKYSHYIEIDDIPYNDIALLKLKPVDGHCALESKYVKTVCLPDGPFLSGTECYISGWGVTETGEGSRHLLDAKVKLISNTICNSRQLYDHSIDDNMICAGNLQKPGQDSCQGDSGGPLTCEKDGTSYIYGIVSWGLECGKRPGVYTQVTKFLTWIKATMEKEASF", "length": 558, "header": "sp|Q5E9Z2-1|HABP2_BOVIN Isoform 1 of Factor VII-activating protease OS=Bos taurus OX=9913 GN=HABP2 PE=2 SV=1 CANONICAL=Q5E9Z2-1" }, "locus": { "chromosome": "26", "start_pos": 34061122, "end_pos": 34026901, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025732.4", "url": "https://www.ensembl.org/id/ENSBTAT00000025732.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025732.3", "url": "https://www.ensembl.org/id/ENSBTAP00000025732.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 54, "start_aa": "Asn", "end_pos": 54, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn54", "evidence": [ { "id": "Q5E9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z2", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:507993", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507993", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q14520-1", "protein_name": "Factor VII-activating protease", "gene_name": "HABP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFARMSDLHVLLLMALVGKTACGFSLMSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLTHAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPCGRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPDQFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTAAHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGSRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVYTQVTKFLNWIKATIKSESGF", "length": 560 }, "evidence": [ { "id": "Q5E9Z2", "url": "https://omabrowser.org/oma/group/Q5E9Z2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6L711-1", "protein_name": "Factor VII-activating protease", "gene_name": "Habp2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSVVMLVFRVLLLIALVGNSAIGLSLMPFIAPPDPDWTPDDYYYSYEQSSPDKDASVTQTSPENPDWYYEDDDPCQSNPCEHGGDCIIRGNTFSCSCPAPFSGSRCQTVQNKCKDNPCVQGDCLITQTPPYYRCACKYPYTGPDCSKVLPVCRPNPCQNGGVCSRHRRRSRFSCACPDQYKGRFCEIGPDDCYVGDGYSYRGKVSRTVNQNPCLYWNSHLLLQENYNMFMEDAETHGIADHNFCRNPDGDHKPWCFVKVNSEKVKWEYCNVEVCPESDAANPVGSLQEPVMELPGFDSCGKTEMTEHAVKRIYGGFKSTAGKHPWQVSLQTSLPLTTSMPQGHFCGGSLIHPCWVLTAAHCTDMSTKHLKVVLGDQDLKKTESHEQTFRVEKILKYSQYNERDEIPHNDIALLKLKPVGGHCALESKYVKTVCLPSDPFPSGTECHISGWGVTETGEGSRQLLDAKVKLIANALCNSRQLYDHTIDDSMICAGNLQKPGSDTCQGDSGGPLTCEKDGTYYVYGIVSWGQECGKKPGVYTQVTKFLNWIKTTMHKEAGL", "length": 558 }, "evidence": [ { "id": "Q5E9Z2", "url": "https://omabrowser.org/oma/group/Q5E9Z2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8K0D2-1", "protein_name": "Factor VII-activating protease", "gene_name": "Habp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFVRMLVFRVLLLIALVGKSVIGLSLMSFIAPPDPDWTPDDYYYSYEQSSPDEDPSVTQTTPENPDWYYEDDDPCQSNPCEHGGDCIIRGDTFSCSCPAPFSGSRCQTAQNKCKDNPCVHGDCLITQKHPYYRCACKYPYTGPDCSKVLPACRPNPCQNGGVCSRHRRRSRFTCACPDQYKGKFCEIGPDDCYVGDGYSYRGKVSKTVNQNPCLYWNSHLLLQETYNMFMEDAETHGIAEHNFCRNPDGDHKPWCFVKVNSEKVKWEYCDVTVCPVPDTPNPVESLLEPVMELPGFESCGKTEVAEHAVKRIYGGFKSTAGKHPWQVSLQTSLPLTTSMPQGHFCGGALIHPCWVLTAAHCTDINTKHLKVVLGDQDLKKTESHEQTFRVEKILKYSQYNERDEIPHNDIALLKLKPVGGHCALESRYVKTVCLPSDPFPSGTECHISGWGVTETGEGSRQLLDAKVKLIANPLCNSRQLYDHTIDDSMICAGNLQKPGSDTCQGDSGGPLTCEKDGTYYVYGIVSWGQECGKKPGVYTQVTKFLNWIKTTMHREAGL", "length": 558 }, "evidence": [ { "id": "Q5E9Z2", "url": "https://omabrowser.org/oma/group/Q5E9Z2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z2", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z2", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z2", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z2", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z2", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2" } ], "pmid": "" }, { "name": "blood coagulation", "id": "GO:0007596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z2", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 54, "end_pos": 56, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9Z2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 558, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9Z2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9Z2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5E9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2" }, { "id": "PRU00076", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00076" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like 1", "eco_id": "ECO_0000255", "start_pos": 71, "end_pos": 107, "start_aa": "Glu", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5E9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2" }, { "id": "PRU00076", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00076" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like 2", "eco_id": "ECO_0000255", "start_pos": 109, "end_pos": 146, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5E9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2" }, { "id": "PRU00076", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00076" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like 3", "eco_id": "ECO_0000255", "start_pos": 148, "end_pos": 186, "start_aa": "Val", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5E9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2" }, { "id": "PRU00121", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00121" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kringle", "eco_id": "ECO_0000255", "start_pos": 191, "end_pos": 274, "start_aa": "Asp", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5E9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z2" }, { "id": "PRU00274", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00274" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000255", "start_pos": 312, "end_pos": 553, 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"count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5BIS9-1", "uniprot_ac": "Q5BIS9", "uniprot_id": "AAKB1_BOVIN", "mass": { "chemical_mass": 30287.0, "monoisotopic_mass": 30287.0 }, "refseq": { "ac": "NP_001019729", "name": "5'-AMP-activated protein kinase subunit beta-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019729" }, "gene_names": [ { "name": "PRKAB1", "type": "recommended", "evidence": [ { "id": "Q5BIS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIS9" } ] }, { "name": "PRKAB1", "type": "synonym", "evidence": [ { "id": "NP_001019729", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019729" } ] } ], "protein_names": [ { "name": "5'-AMP-activated protein kinase subunit beta-1", "type": "recommended", "evidence": [ { "id": "Q5BIS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIS9/entry#names_and_taxonomy" } ] }, { "name": "5'-AMP-activated protein kinase subunit beta-1", "type": "synonym", "evidence": [ { "id": "NP_001019729", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019729" } ] }, { "name": "AMP-activated protein kinase beta 1 non-catalytic subunit", "type": "synonym", "evidence": [ { "id": "NP_001019729", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019729" } ] }, { "name": "AMPK beta-1 chain", "type": "synonym", "evidence": [ { "id": "NP_001019729", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019729" } ] }, { "name": "AMPK subunit beta-1", "type": "synonym", "evidence": [ { "id": "NP_001019729", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019729" }, { "id": "Q5BIS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIS9/entry#names_and_taxonomy" } ] }, { "name": "AMPKb", "type": "synonym", "evidence": [ { "id": "NP_001019729", "database": "RefSeq", "url": 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In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5D0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D0#function" }, { "database": "UniProtKB", "id": "ARBA00025180", "url": "https://www.uniprot.org/uniprotkb/ARBA00025180#function" }, { "database": "UniProtKB", "id": "A0AAA9TNR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNR6#function" }, { "database": "UniProtKB", "id": "Q5BIS9", "url": "https://www.uniprot.org/uniprotkb/Q5BIS9#function" } ] }, { "annotation": "Sequence analysis of 811 Chinese indigenous bovine individuals revealed 29 single nucleotide polymorphisms (SNPs) of bovine PRKAB1 gene.", "evidence": [ { "database": "RefSeq", "id": "NP_001019729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019729" }, { "database": "PubMed", "id": "19578998", "url": "https://glygen.org/publication/PubMed/19578998" } ] }, { "annotation": "The extent of genetic polymorphisms in the promoter region of PRKAB1 gene was investigated in a sample of 811 Chinese indigenous bovine individuals.", "evidence": [ { "database": "RefSeq", "id": "NP_001019729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019729" }, { "database": "PubMed", "id": "19609721", "url": "https://glygen.org/publication/PubMed/19609721" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5BIS9", "url": "https://www.uniprot.org/uniprotkb/Q5BIS9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRKAB1", "url": "https://www.uniprot.org/uniprotkb/Q5BIS9", "locus": { "chromosome": "17", "start_pos": 55738716, "end_pos": 55759908, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005940", "url": "https://www.ensembl.org/id/ENSBTAG00000005940" } ] } } ], "crossref": [ { "id": "Q5BIS9", "url": "https://alphafold.ebi.ac.uk/entry/Q5BIS9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005940", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005940", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02859", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02859", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534107", "url": "https://www.ncbi.nlm.nih.gov/gene/534107", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037256", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037256", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534107", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534107", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QRTINAP", "url": "https://omabrowser.org/oma/group/QRTINAP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5BIS9", "url": "https://www.orthodb.org/?gene=Q5BIS9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10343", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10343", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10343:SF84", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10343:SF84", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04739", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04739", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16561", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16561", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1632852", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380972", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380972", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5628897", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804756", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9931269", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931269", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001019729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019729", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T5D0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5D0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNR6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BIS9", "url": "https://www.uniprot.org/uniprotkb/Q5BIS9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BIS9-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIS9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNTSSERAALDRQGGHKTPRRDSSGGSKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPVVTSQLGTVNNVIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYISKPEERFKAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI", "length": 270, "header": "sp|Q5BIS9-1|AAKB1_BOVIN Isoform 1 of 5'-AMP-activated protein kinase subunit beta-1 OS=Bos taurus OX=9913 GN=PRKAB1 PE=2 SV=3 CANONICAL=Q5BIS9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T5D0-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIS9/entry#A0AAA9T5D0-1", "sequence": { "sequence": "MGNTSSERAALDRQGGHKTPRRDSSGGSKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPVVTSQLGTVNNVIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYISKPEERFKAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKMALGEHGPENQHLELAGLPRRPQASEPRPHSRAPGYQHIPPGPQLVTCKLHR", "length": 297, "header": "tr|A0AAA9T5D0-1|AAKB1_BOVIN Computationally mapped isoform of 5'-AMP-activated protein kinase subunit beta-1 OS=Bos taurus OX=9913 GN=PRKAB1 PE=2 SV=1 CANONICAL=Q5BIS9-1" }, "locus": { "chromosome": "17", "start_pos": 55759643, "end_pos": 55738879, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089730.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089730.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090941.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090941.1" } ] } }, { "isoform_ac": "A0AAA9TNR6-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIS9/entry#A0AAA9TNR6-1", "sequence": { "sequence": "MGNTSSERAALDRQGGHKTPRRDSSGGSKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPVVTSQLGTVNNVIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYISKPEERFKAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKYIPLEIDAHTHTHTPASS", "length": 263, "header": "tr|A0AAA9TNR6-1|AAKB1_BOVIN Computationally mapped isoform of 5'-AMP-activated protein kinase subunit beta-1 OS=Bos taurus OX=9913 GN=PRKAB1 PE=2 SV=1 CANONICAL=Q5BIS9-1" }, "locus": { "chromosome": "17", "start_pos": 55759643, "end_pos": 55748760, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123391.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123391.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097980.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097980.1" } ] } }, { "isoform_ac": "Q5BIS9-1", "url": "https://www.uniprot.org/uniprotkb/Q5BIS9/entry#Q5BIS9-1", "sequence": { "sequence": "MGNTSSERAALDRQGGHKTPRRDSSGGSKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPVVTSQLGTVNNVIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYISKPEERFKAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI", "length": 270, "header": "sp|Q5BIS9-1|AAKB1_BOVIN Isoform 1 of 5'-AMP-activated protein kinase subunit beta-1 OS=Bos taurus OX=9913 GN=PRKAB1 PE=2 SV=3 CANONICAL=Q5BIS9-1" }, "locus": { "chromosome": "17", "start_pos": 55759643, "end_pos": 55751728, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007798.5", "url": "https://www.ensembl.org/id/ENSBTAT00000007798.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007798.3", "url": "https://www.ensembl.org/id/ENSBTAP00000007798.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 101, "end_pos": 101, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5BIS9", "url": "https://www.uniprot.org/uniprotkb/Q5BIS9" } ], "site_lbl": "Ser101" }, { "start_pos": 108, "end_pos": 108, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by autocatalysis", "evidence": [ { "database": "UniProtKB", "id": "Q5BIS9", "url": "https://www.uniprot.org/uniprotkb/Q5BIS9" } ], "site_lbl": "Ser108" }, { "start_pos": 148, "end_pos": 148, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5BIS9", "url": "https://www.uniprot.org/uniprotkb/Q5BIS9" } ], "site_lbl": "Thr148" }, { "start_pos": 182, "end_pos": 182, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5BIS9", "url": "https://www.uniprot.org/uniprotkb/Q5BIS9" } ], "site_lbl": "Ser182" }, { 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"kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5BIS9", "url": "https://www.uniprot.org/uniprotkb/Q5BIS9" } ], "site_lbl": "Ser96" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5BIS9", "url": "https://www.uniprot.org/uniprotkb/Q5BIS9" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "Single nucleotide polymorphisms and haplotypic diversity in the bovine PRKAB1 gene.", "journal": "Molecular biotechnology", "date": "2009-11", "authors": "Zhang Qin, Chen Hong, Zhao Sheng, Zhang Li, Zhang Liangzhi, Li Fei, Wang Xueming", "evidence": [ { "database": "RefSeq", "id": "NP_001019729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019729" } ], "reference": [ { "type": "PubMed", "id": "19578998", "url": "https://glygen.org/publication/PubMed/19578998" } ] }, { "title": "Polymorphisms in the promoter region of bovine PRKAB1 gene.", "journal": "Molecular biology reports", "date": "2010-01", "authors": "Zhang Qin, Chen Hong, Zhao Sheng, Zhang Li, Zhang Liangzhi, Wang Xueming", "evidence": [ { "database": "RefSeq", "id": "NP_001019729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019729" } ], "reference": [ { "type": "PubMed", "id": "19609721", "url": "https://glygen.org/publication/PubMed/19609721" } ] } ], "pathway": [ { "id": "bta:534107", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534107", "resource": "KEGG Pathway" }, { "id": "R-BTA-1632852", "name": "", "url": 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"field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9E3-1", "uniprot_ac": "Q5E9E3", "uniprot_id": "C1QA_BOVIN", "mass": { "chemical_mass": 25802.0, "monoisotopic_mass": 25802.0 }, "refseq": { "ac": "NP_001014945", "name": "complement C1q subcomponent subunit A precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014945" }, "gene_names": [ { "name": "C1QA", "type": "recommended", "evidence": [ { "id": "Q5E9E3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ] }, { "name": "C1QA", "type": "synonym", "evidence": [ { "id": "NP_001014945", "database": "RefSeq", "url": 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The C1Q subcomplex also recognizes and binds phosphatidylserine exposed on the surface of cells undergoing programmed cell death, possibly promoting activation of the complement system.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3#function" }, { "database": "UniProtKB", "id": "P02745", "url": "https://www.uniprot.org/uniprotkb/P02745#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C1QA", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3", "locus": { "chromosome": "2", "start_pos": 130189866, "end_pos": 130200036, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007153", "url": "https://www.ensembl.org/id/ENSBTAG00000007153" } ] } } ], "crossref": [ { "id": "Q5E9E3", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9E3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007153", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007153", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534961", "url": "https://www.ncbi.nlm.nih.gov/gene/534961", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534961", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534961", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MEGPQGW", "url": "https://omabrowser.org/oma/group/MEGPQGW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9E3", "url": "https://www.orthodb.org/?gene=Q5E9E3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15427", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15427", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15427:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15427:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00386", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00386", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-173623", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-173623", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-977606", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977606", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001014945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014945", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T666", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T666", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T666-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T666-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YR30", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YR30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR30-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9E3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAPRGWLVISVLAISLASSVTEDVCRAPDGTHGSAGIPGRPGRPGLKGERGEPGAPAIQTGIRGLKGDQGDPGPPGNPGRMGYPGPSGPMGPAGLPGLKGTKGSPGNIKDQPRPAFSAVGPNSVSRDNVVVFGKVITNQENVYQNNTGRFRCSVPGYYYFTFQVVSNWDICLSIRSSRRDQIQPLGFCDFNSKGFFQVVSGGTVLHLQQGDQVWIEKDPSKGRIYHGSEADSIFSGFLIFPSA", "length": 244, "header": "sp|Q5E9E3-1|C1QA_BOVIN Isoform 1 of Complement C1q subcomponent subunit A OS=Bos taurus OX=9913 GN=C1QA PE=2 SV=1 CANONICAL=Q5E9E3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T666-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3/entry#A0AAA9T666-1", "sequence": { "sequence": "MNTCCFCDREKVLQVTDLREGSFYPAALCLRESHCPPGTPLPPPSRQPLASLSSACTSCGWGRMSRAPVLLSGTMEAPRGWLVISVLAISLASSVTEDVCRAPDGTHGSAGIPGRPGRPGLKGERGEPGAPAIQTGIRGLKGDQGDPGPPGNPGRMGYPGPSGPMGPAGLPGLKGTKGSPGNIKDQPRPAFSAVGPNSVSRDNVVVFGKVITNQENVYQNNTGRFRCSVPGYYYFTFQVVSNWDICLSIRSSRRDQIQPLGFCDFNSKGFFQVVSGGTVLHLQQGDQVWIEKDPSKGRIYHGSEADSIFSGFLIFPSA", "length": 318, "header": "tr|A0AAA9T666-1|C1QA_BOVIN Computationally mapped isoform of Complement C1q subcomponent subunit A OS=Bos taurus OX=9913 GN=C1QA PE=2 SV=1 CANONICAL=Q5E9E3-1" }, "locus": { "chromosome": "2", "start_pos": 130193113, "end_pos": 130190057, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088648.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088648.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093363.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093363.1" } ] } }, { "isoform_ac": "A0AAF6YR30-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3/entry#A0AAF6YR30-1", "sequence": { "sequence": "MEGEILKAPRGGEGFRKKAKIKTISIIKSRPGEGEKVDRGSKIDKMQSKKMMLEGTLQTSLPAFSLVFSLFLRNGTMEAPRGWLVISVLAISLASSVTEDVCRAPDGTHGSAGIPGRPGRPGLKGERGEPGAPAIQTGIRGLKGDQGDPGPPGNPGRMGYPGPSGPMGPAGLPGLKGTKGSPGNIKDQPRPAFSAVGPNSVSRDNVVVFGKVITNQENVYQNNTGRFRCSVPGYYYFTFQVVSNWDICLSIRSSRRDQIQPLGFCDFNSKGFFQVVSGGTVLHLQQGDQVWIEKDPSKGRIYHGSEADSIFSGFLIFPSA", "length": 320, "header": "tr|A0AAF6YR30-1|C1QA_BOVIN Computationally mapped isoform of Complement C1q subcomponent subunit A OS=Bos taurus OX=9913 GN=C1QA PE=2 SV=1 CANONICAL=Q5E9E3-1" }, "locus": { "chromosome": "2", "start_pos": 130197312, "end_pos": 130190057, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009415.4", "url": "https://www.ensembl.org/id/ENSBTAT00000009415.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009415.3", "url": "https://www.ensembl.org/id/ENSBTAP00000009415.3" } ] } }, { "isoform_ac": "Q5E9E3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3/entry#Q5E9E3-1", "sequence": { "sequence": "MEAPRGWLVISVLAISLASSVTEDVCRAPDGTHGSAGIPGRPGRPGLKGERGEPGAPAIQTGIRGLKGDQGDPGPPGNPGRMGYPGPSGPMGPAGLPGLKGTKGSPGNIKDQPRPAFSAVGPNSVSRDNVVVFGKVITNQENVYQNNTGRFRCSVPGYYYFTFQVVSNWDICLSIRSSRRDQIQPLGFCDFNSKGFFQVVSGGTVLHLQQGDQVWIEKDPSKGRIYHGSEADSIFSGFLIFPSA", "length": 244, "header": "sp|Q5E9E3-1|C1QA_BOVIN Isoform 1 of Complement C1q subcomponent subunit A OS=Bos taurus OX=9913 GN=C1QA PE=2 SV=1 CANONICAL=Q5E9E3-1" }, "locus": { "chromosome": "2", "start_pos": 130191813, "end_pos": 130190057, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000040146.5", "url": "https://www.ensembl.org/id/ENSBTAT00000040146.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039925.3", "url": "https://www.ensembl.org/id/ENSBTAP00000039925.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-galactosylation", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "K", "relation": "attached", "comment": "O-linked (Gal...) hydroxylysine;O-galactosylation", "icn3d_view": {}, "start_pos": 100, "start_aa": "Lys", "end_pos": 100, "end_aa": "Lys", "residue": "Lys", "site_lbl": "Lys100", "evidence": [ { "id": "Q5E9E3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 146, "start_aa": "Asn", "end_pos": 146, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn146", "evidence": [ { "id": "Q5E9E3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-galactosylation", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "K", "relation": "attached", "comment": "O-linked (Gal...) hydroxylysine;O-galactosylation", "icn3d_view": {}, "start_pos": 48, "start_aa": "Lys", "end_pos": 48, "end_aa": "Lys", "residue": "Lys", "site_lbl": "Lys48", "evidence": [ { "id": "Q5E9E3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-galactosylation", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "K", "relation": "attached", "comment": "O-linked (Gal...) hydroxylysine;O-galactosylation", "icn3d_view": {}, "start_pos": 67, "start_aa": "Lys", "end_pos": 67, "end_aa": "Lys", "residue": "Lys", "site_lbl": "Lys67", "evidence": [ { "id": "Q5E9E3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:534961", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534961", "resource": "KEGG Pathway" }, { "id": "R-BTA-173623", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-173623", "resource": "Reactome", "description": "Classical antibody-mediated complement activation" }, { "id": "R-BTA-977606", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977606", "resource": "Reactome", "description": "Regulation of Complement cascade" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BNF7-1", "protein_name": "Complement C1q subcomponent subunit A", "gene_name": "C1QA", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEAPRGWLVIMISVLAVSLASSAAQDTCRDLDGRDGAAGKPGRPGRPGPKGERGEPGAPAFQTGIRGLKGDQGESGSPGKPGRMGYPGPSGPPGLPGLPGLKGIKGNPGNIKDQRRPAFSAVRQNPPTSGNVVIFDEVITNQEGAYKSQLGQFICDVPGYYYFTFQVVSKWDLCLYIMSSRRDQVQQSLGFCDFNSKGLFQVVSGGTVLQLQRGDKVWIQRDPNKGRIYQGSEADSVFSGFLIFPST", "length": 247 }, "evidence": [ { "id": "Q5E9E3", "url": "https://omabrowser.org/oma/group/Q5E9E3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2QPU2-1", "protein_name": "Complement C1q subcomponent subunit A", "gene_name": "C1qa", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEASWGWLVACVLAMTLVSTVTEDVCRAPNGKDGVAGNPGRPGRPGPKGERGEPGAAGIRTGIRGLKGDQGESGPPGKPGNMGFPGPTGPLGSSGPQGLKGVKGNPGNIRDQPRPAFSAIRQNPPTVGNVVIFDKVITNEEGPYQNKTGRFICAVPGFYYFTFQVTSKWDICLSIMFSSHGQTRSPLGFCDANSKGLFQVVSGSTVLHLQRGDQVWIEKDPAKGRIYQGTEVDSIFSGFLIFPSA", "length": 245 }, "evidence": [ { "id": "Q5E9E3", "url": "https://omabrowser.org/oma/group/Q5E9E3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0Z078-1", "protein_name": "Complement C1q subcomponent subunit A", "gene_name": "C1QA", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQLSLWLVTSSLAAVLGMEQLEDGVCRAPNGKDGFPGIPGLDGRPGQKGDVGEPGRSAPRTGIRGPKGDKGESGLPGIPGNRGYHGPPGLPGMPGMPGLKGAKGNAGSFQQQQHPAFSASRTMSLFRGTTVVFNNIITNEENSYSPQTGEFTCSIPGIYYFAYQVVSNGDLCLSITKNAERVVSFCDNNSRNILQVNSGSSVLSLAMGDRVSVNTIPTKGNLIYHGSEADSVFSGFMLYPQTG", "length": 243 }, "evidence": [ { "id": "Q5E9E3", "url": "https://omabrowser.org/oma/group/Q5E9E3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P02745-1", "protein_name": "Complement C1q subcomponent subunit A", "gene_name": "C1QA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGPRGWLVLCVLAISLASMVTEDLCRAPDGKKGEAGRPGRRGRPGLKGEQGEPGAPGIRTGIQGLKGDQGEPGPSGNPGKVGYPGPSGPLGARGIPGIKGTKGSPGNIKDQPRPAFSAIRRNPPMGGNVVIFDTVITNQEEPYQNHSGRFVCTVPGYYYFTFQVLSQWEICLSIVSSSRGQVRRSLGFCDTTNKGLFQVVSGGMVLQLQQGDQVWVEKDPKKGHIYQGSEADSVFSGFLIFPSA", "length": 245 }, "evidence": [ { "id": "Q5E9E3", "url": "https://omabrowser.org/oma/group/Q5E9E3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P98086-1", "protein_name": "Complement C1q subcomponent subunit A", "gene_name": "C1qa", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METSQGWLVACVLTMTLVWTVAEDVCRAPNGKDGAPGNPGRPGRPGLKGERGEPGAAGIRTGIRGFKGDPGESGPPGKPGNVGLPGPSGPLGDSGPQGLKGVKGNPGNIRDQPRPAFSAIRQNPMTLGNVVIFDKVLTNQESPYQNHTGRFICAVPGFYYFNFQVISKWDLCLFIKSSSGGQPRDSLSFSNTNNKGLFQVLAGGTVLQLRRGDEVWIEKDPAKGRIYQGTEADSIFSGFLIFPSA", "length": 245 }, "evidence": [ { "id": "Q5E9E3", "url": "https://omabrowser.org/oma/group/Q5E9E3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "pmid": "" }, { "name": "complement component C1 complex", "id": "GO:0005602", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005602", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "pmid": "" }, { "name": "extrinsic component of presynaptic membrane", "id": "GO:0098888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098888", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "pmid": "" }, { "name": "extrinsic component of postsynaptic membrane", "id": "GO:0098890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098890", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "pmid": "" }, { "name": "complement component C1q complex", "id": "GO:0062167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062167", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "pmid": "" }, { "name": "symbiont cell surface", "id": "GO:0106139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106139", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "pmid": "" }, { "name": "complement activation, classical pathway", "id": "GO:0006958", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006958", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "pmid": "" }, { "name": "microglial cell activation", "id": "GO:0001774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001774", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "pmid": "" }, { "name": "neuron remodeling", "id": "GO:0016322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016322", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "pmid": "" }, { "name": "astrocyte activation", "id": "GO:0048143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048143", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "pmid": "" }, { "name": "complement-mediated synapse pruning", "id": "GO:0150062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150062", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "pmid": "" }, { "name": "vertebrate eye-specific patterning", "id": "GO:0150064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150064", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "pmid": "" }, { "name": "phosphatidylserine binding", "id": "GO:0001786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001786", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "pmid": "" }, { "name": "IgM binding", "id": "GO:0001791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001791", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "pmid": "" }, { "name": "IgG binding", "id": "GO:0019864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019864", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E3", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9E3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 244, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9E3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9E3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5E9E3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" }, { "id": "PRU00368", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00368" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C1q", "eco_id": "ECO_0000255", "start_pos": 110, "end_pos": 244, "start_aa": "Lys", "end_aa": "Ala", "glycosite_overlap": "Asn146" } ], "binding_sites": [ { "evidence": [ { "id": "Q5E9E3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3#function" }, { "id": "Q5E9E3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9E3" } ], "binding_site_uniprot": 198, "amino_acid": "Gln", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 198, "end_pos": 198, "start_aa": "Gln", "end_aa": "Gln", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": 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"https://www.uniprot.org/uniprotkb/Q5EA83/entry#names_and_taxonomy" } ] }, { "name": "HDC", "type": "synonym", "evidence": [ { "id": "Q5EA83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA83/entry#names_and_taxonomy" } ] }, { "name": "histidine decarboxylase", "type": "synonym", "evidence": [ { "id": "NP_001019722", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019722" } ] } ], "function": [ { "annotation": "Catalyzes the biosynthesis of histamine from histidine.", "evidence": [ { "database": "UniProtKB", "id": "Q5EA83", "url": "https://www.uniprot.org/uniprotkb/Q5EA83#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA83", "url": "https://www.uniprot.org/uniprotkb/Q5EA83" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HDC", "url": "https://www.uniprot.org/uniprotkb/Q5EA83", "locus": { "chromosome": "10", "start_pos": 60004776, "end_pos": 59982866, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009911", "url": "https://www.ensembl.org/id/ENSBTAG00000009911" } ] } } ], "crossref": [ { "id": "Q5EA83", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA83", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009911", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009911", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06450", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06450", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515950", "url": "https://www.ncbi.nlm.nih.gov/gene/515950", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021115", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021115", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515950", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515950", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ERDPSHY", "url": "https://omabrowser.org/oma/group/ERDPSHY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EA83", "url": "https://www.orthodb.org/?gene=Q5EA83", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11999", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11999", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11999:SF68", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11999:SF68", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00282", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00282", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-70921", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70921", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001019722", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019722", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "20840", "url": "https://www.rhea-db.org/rhea/20840", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T965", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T965", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T965-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T965-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT55-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA83", "url": "https://www.uniprot.org/uniprotkb/Q5EA83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA83-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA83-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMEPEEYRERGKEMVDYICQYLTTVRERRVTPDVRPGYLRAQLPESAPMEPDSWDSIFGDIERIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPEHFLHHHPGSQGGGVLQSTVSESTLIALLAARKNKILEMKASEPEADESFLNARLVAYASDQAHSSVEKAGLISLVKMKFLPVDENFSLRGEALQKAIKEDRERGLVPIFVCATLGTTGVCAFDCLSELGPICAREGLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVDPVYLRHADSGVATDFMHWQIPLSRRFRSIKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPFFEIPAKRHLGLVVFRLKGPNCLTESVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIQDAATLILSQHCTSQPSPQGANLILQTRGPRALAKEMSFPSVNGAGDDPAHSRKIVMQPPRVGASPVSRHLETLLDPLDDCFSEEAPDVTEHKLSSFLFSYLSVQNKRKAVRSLSCNSVPVSAQKQLTTEGSVKNGSSSRVRIFSRFPEEVMMLKKSAFKKLIKFYSVPNFPECSSQCGLQLPCCPLQAMV", "length": 658, "header": "sp|Q5EA83-1|DCHS_BOVIN Isoform 1 of Histidine decarboxylase OS=Bos taurus OX=9913 GN=HDC PE=2 SV=1 CANONICAL=Q5EA83-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T965-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA83/entry#A0AAA9T965-1", "sequence": { "sequence": "MMEPEEYRERGKEMVDYICQYLTTVRERRVTPDVRPGYLRAQLPESAPMEPDSWDSIFGDIERIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPEHFLHHHPGSQGGGVLQSTVSESTLIALLAARKNKILEMKASEPEADESFLNARLVAYASDQAHSSVEKAGLISLVKMKFLPVDENFSLRGEALQKAIKEDRERGLVPIFVCATLGTTGVCAFDCLSELGPICAREGLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVDPVYLRHADSGVATDFMGTEMAKYFESLVRNDPFFEIPAKRHLGLVVFRLKGPNCLTESVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIQDAATLILSQHCTSQPSPQGANLILQTRGPRALAKEMSFPSVNGAGDDPAHSRKIVMQPPRVGASPVSRHLETLLDPLDDCFSEEAPDVTEHKLSSFLFSYLSVQNKRKAVRSLSCNSVPVSAQKQLTTEGSVKNGSSSRVRIFSRFPEEVMMLKKSAFKKLIKFYSVPNFPECSSQCGLQLPCCPLQAMV", "length": 625, "header": "tr|A0AAA9T965-1|DCHS_BOVIN Computationally mapped isoform of Histidine decarboxylase OS=Bos taurus OX=9913 GN=HDC PE=2 SV=1 CANONICAL=Q5EA83-1" }, "locus": { "chromosome": "10", "start_pos": 60004444, "end_pos": 59982883, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128550.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128550.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093151.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093151.1" } ] } }, { "isoform_ac": "A0AAA9TT55-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA83/entry#A0AAA9TT55-1", "sequence": { "sequence": "SEMVDYICQYLTTVRERRVTPDVRPGYLRAQLPESAPMEPDSWDSIFGDIERIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPEHFLHHHPGSQGGGVLQSTVSESTLIALLAARKNKILEMKASEPEADESFLNARLVAYASDQAHSSVEKAGLISLVKMKFLPVDENFSLRGEALQKAIKEDRERGLVPIFVCATLGTTGVCAFDCLSELGPICAREGLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVDPVYLRHADSGVATDFMHWQIPLSRRFRSIKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPFFEIPAKRHLGLVVFRLKGPNCLTESVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIQDAATLILSQHCTSQPSPQGANLILQTRGPRALAKEMSFPSVNGAGDDPAHSRKIVMQPPRVGASPVSRHLETLLDPLDDCFSEEAPDVTEHKLSSFLFSYLSVQNKRKAVRSLSCNSVPVSAQKQLTTEGSVKNGSSSRVRIFSRFPEEVMMLKKSAFKKLIKFYSVPNFPECSSQCGLQLPCCPLQAMV", "length": 647, "header": "tr|A0AAA9TT55-1|DCHS_BOVIN Computationally mapped isoform of Histidine decarboxylase OS=Bos taurus OX=9913 GN=HDC PE=2 SV=1 CANONICAL=Q5EA83-1" }, "locus": { "chromosome": "10", "start_pos": 60004444, "end_pos": 59984985, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096798.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096798.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101549.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101549.1" } ] } }, { "isoform_ac": "Q5EA83-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA83/entry#Q5EA83-1", "sequence": { "sequence": "MMEPEEYRERGKEMVDYICQYLTTVRERRVTPDVRPGYLRAQLPESAPMEPDSWDSIFGDIERIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPEHFLHHHPGSQGGGVLQSTVSESTLIALLAARKNKILEMKASEPEADESFLNARLVAYASDQAHSSVEKAGLISLVKMKFLPVDENFSLRGEALQKAIKEDRERGLVPIFVCATLGTTGVCAFDCLSELGPICAREGLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVDPVYLRHADSGVATDFMHWQIPLSRRFRSIKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPFFEIPAKRHLGLVVFRLKGPNCLTESVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIQDAATLILSQHCTSQPSPQGANLILQTRGPRALAKEMSFPSVNGAGDDPAHSRKIVMQPPRVGASPVSRHLETLLDPLDDCFSEEAPDVTEHKLSSFLFSYLSVQNKRKAVRSLSCNSVPVSAQKQLTTEGSVKNGSSSRVRIFSRFPEEVMMLKKSAFKKLIKFYSVPNFPECSSQCGLQLPCCPLQAMV", "length": 658, "header": "sp|Q5EA83-1|DCHS_BOVIN Isoform 1 of Histidine decarboxylase OS=Bos taurus OX=9913 GN=HDC PE=2 SV=1 CANONICAL=Q5EA83-1" }, "locus": { "chromosome": "10", "start_pos": 60004444, "end_pos": 59982883, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013083.4", "url": "https://www.ensembl.org/id/ENSBTAT00000013083.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013083.2", "url": "https://www.ensembl.org/id/ENSBTAP00000013083.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA83", "url": "https://www.uniprot.org/uniprotkb/Q5EA83" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:515950", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515950", "resource": "KEGG Pathway" }, { "id": "R-BTA-70921", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70921", "resource": "Reactome", "description": "Histidine catabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z172-1", "protein_name": "Histidine decarboxylase", "gene_name": "HDC", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQKGLCYNKREEWKEMVDYICQYLSNVRERRVTPDVQPGYMRAQLPDSAPMDPDSWDNIFGDIEKIIMPGVVHWQSPHMHAYFPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPDKFLHHHPDSVGGGVLQSTVSESTLVALLAARKNKILEMKLSEPDADESSLNSRLIAYASDQAHSSVEKAGLISLVKMKFLPVDENFSLRGETLKKAIAEDRKKGLVPIFVCATLGTTGVCAFDSLSELGPICGAEGLWLHIDAAYAGTAFLCPEFRLFLDGIEYADSFAFNPSKWMMVHFDCTGFWVKDKYKLHQTFSVNPVYLRHPNSGAAVDFMHWQIPLSRRFRSLKLWFVIRSFGVKKLQAHVRHGTETAKFFESLVRSDPLFEIPAKRHLGLVVFRLKGPNWLTEKLLKELSSSGRLFLIPATIHDKFIIRFTVTSQFTTREDILQDWNIIQRTAAQIISQHNELHCVSSGDEAKIPNMISEPSSSVISHASQLYLEGKYKIPSRKIVGQPKKLAASPSTCVISQQVQGQGDLDDCFPEDVQDVTKHKLTSFLFSYLSVQGKKKTARSLSCNSVPMTDLLEQCNPKTTDSDQKEPHANGRILSRLPEEVMMLKKSAFKKLIKFYSVPSFSECSIQCGLQLPCCPLQAIV", "length": 667 }, "evidence": [ { "id": "Q5EA83", "url": "https://omabrowser.org/oma/group/Q5EA83/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SQH5-1", "protein_name": "Histidine decarboxylase", "gene_name": "HDC", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMGPEEYRERGKEMVDYICQYLSTVRERRVTPDVRPGYLRGQLPERAPEEPDSWDSIFGDIERIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPVCTELEMNVMDWLAKMLGLPDHFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKASEPGADESCLNARLIAYASDQAHSSVEKAGLISLVKMKFLPVDDNFSLRGEALQKAIEEDRERGLVPVFVCATLGTTGVCAFDCLSELGPICASEGLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPVYLRHANSGAATDFMHWQIPLSRRFRSIKLWFVIRSFGVKNLQAHVRHGIEMAKYFESLVRNDPFFEIPAKRHLGLVVFRLKGPNCLTESVLKEIAKAGHLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIHDAATLILSQHCTSQPSPRLGNLIPQTQGPRALAKEMSFPSVNGAEDDPAQARKIIRQPPSVGASLVRGGGSCHLEILQDPFDDCFSEEAPDVTKHKLSSFLFSYLSVQNKKKAVRSLSCNSVPVSAQKPLPTDGSVKNGGSSRVRIFSRFPEEMMVLKKSAFKKLIKFYSVPSFPECSSQCGFQLPCCPLQAMV", "length": 662 }, "evidence": [ { "id": "Q5EA83", "url": "https://omabrowser.org/oma/group/Q5EA83/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P19113-1", "protein_name": "Histidine decarboxylase", "gene_name": "HDC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGDIERIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPEHFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESCLNARLVAYASDQAHSSVEKAGLISLVKMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDCLSELGPICAREGLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVATDFMHWQIPLSRRFRSVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNCLTENVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIRDAATLILSQHCTSQPSPRVGNLISQIRGARAWACGTSLQSVSGAGDDPVQARKIIKQPQRVGAGPMKRENGLHLETLLDPVDDCFSEEAPDATKHKLSSFLFSYLSVQTKKKTVRSLSCNSVPVSAQKPLPTEASVKNGGSSRVRIFSRFPEDMMMLKKSAFKKLIKFYSVPSFPECSSQCGLQLPCCPLQAMV", "length": 662 }, "evidence": [ { "id": "Q5EA83", "url": "https://omabrowser.org/oma/group/Q5EA83/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P23738-1", "protein_name": "Histidine decarboxylase", "gene_name": "Hdc", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMEPCEYREYREYYRARGKEMVDYISQYLSTVRERQVTPNVQPGYLRAQLPASAPEEPDSWDSIFGDIERVIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNIMDWLAKMLGLPEYFLHHHPSSRGGGVLQSTVSESTLIALLAARKNKILAMKACEPDANESSLNARLVAYTSDQAHSSVEKAGLISLVKIRFLPVDDNFSLRGEALQKAIEEDKQQGLVPVFVCATLGTTGVCAFDRLSELGPICASEGLWLHVDAAYAGTAFLCPELRGFLEGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGAATDFMHWQIPLSRRFRSIKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRSDPSFEIPAKRHLGLVVFRLKGPNCLTESVLKEIAKAGQLFLIPATIQDKLIIRFTVTSQFTTKEDILRDWHLIQEAANLVLSQHCTSQPSPRAKNVIPPPPGTRGLSLESVSEGGDDPAQARKIIKQPGASLARREGGSDLETMPDPFDDCFSEEAPNTTKHKLSSFLFSYLSVQNRRKTTRSLSCNSVPMSAQKSLPADASLKNGGSFRARIFSGFPEQMMMMKKGAFKKLIKFYSVPSFPECSSQCARQLPCCPLEAMV", "length": 662 }, "evidence": [ { "id": "Q5EA83", "url": "https://omabrowser.org/oma/group/Q5EA83/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5EA83", "url": "https://www.uniprot.org/uniprotkb/Q5EA83" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "Q5EA83", "url": "https://www.uniprot.org/uniprotkb/Q5EA83" } ], "pmid": "" }, { "name": "histidine decarboxylase activity", "id": "GO:0004398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004398", "evidence": [ { "database": "UniProtKB", "id": "Q5EA83", "url": "https://www.uniprot.org/uniprotkb/Q5EA83" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "L-histidine catabolic process", "id": "GO:0006548", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006548", "evidence": [ { "database": "UniProtKB", "id": "Q5EA83", "url": "https://www.uniprot.org/uniprotkb/Q5EA83" } ], "pmid": "" }, { "name": "histamine biosynthetic process", "id": "GO:0001694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001694", "evidence": [ { "database": "UniProtKB", "id": "Q5EA83", "url": "https://www.uniprot.org/uniprotkb/Q5EA83" } ], "pmid": "" }, { "name": "catecholamine biosynthetic process", "id": "GO:0042423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042423", "evidence": [ { "database": "UniProtKB", "id": "Q5EA83", "url": "https://www.uniprot.org/uniprotkb/Q5EA83" } ], "pmid": "" }, { "name": "amino acid metabolic process", "id": "GO:0006520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006520", "evidence": [ { "database": "UniProtKB", "id": "Q5EA83", "url": "https://www.uniprot.org/uniprotkb/Q5EA83" } ], "pmid": "" }, { "name": "carboxylic acid metabolic process", "id": "GO:0019752", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019752", "evidence": [ { "database": "UniProtKB", "id": "Q5EA83", "url": "https://www.uniprot.org/uniprotkb/Q5EA83" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 216, "end_pos": 218, "annotation": "n_glycosylation_sequon" }, { "start_pos": 602, "end_pos": 604, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20840", "name": "", "equation": "L-histidine + H(+) = histamine + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5EA83-1" ], "evidence": [ { "id": "20840", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20840" } ] }, { "id": "R-BTA-977301", "name": "Histidine is decarboxylated to histamine", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-175992" ], "enzyme_list": [ "Q5EA83-1" ], "evidence": [ { "id": "R-BTA-977301", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977301" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-175992", "participant_name": "Hist [cytosol]", "crossref": [ { "id": "ZINC000000388081", "database": "ZINC", "url": "" }, { "id": "58432", "database": "ChEBI", "url": "" }, { "id": "C00388", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q5EA83", "gene_name": "HDC", "activity": [ { "ec_number": "4.1.1.22", "activity": "L-histidine + H(+) = histamine + CO2.", "evidence": [ { "id": "Q5EA83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA83" } ] }, { "ec_number": "4.1.1.22", "activity": "", "evidence": [ { "id": "Q5EA83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA83" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA83-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 658, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA83-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA83" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "4.1.1.22", "ec_name": "L-histidine + H(+) = histamine + CO2.", "evidence": [ { "id": "4.1.1.22", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.22" }, { "id": "4.1.1.22", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=4.1.1.22" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 216, "end_pos": 218 }, { "start_pos": 602, "end_pos": 604 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q56JV9-1", "uniprot_ac": "Q56JV9", "uniprot_id": "RS3A_BOVIN", "mass": { "chemical_mass": 29945.0, "monoisotopic_mass": 29945.0 }, "refseq": { "ac": "NP_001029210", "name": "small ribosomal subunit protein eS1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029210" }, "gene_names": [ { "name": "RPS3A", "type": "recommended", "evidence": [ { "id": "Q56JV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV9" } ] }, { "name": "RPS3AE", "type": "synonym", "evidence": [ { "id": "NP_001029210", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029210" } ] }, { "name": "RPS3A", "type": "synonym", "evidence": [ { "id": "NP_001029210", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029210" } ] } ], "protein_names": [ { "name": "Small ribosomal subunit protein eS1", "type": "recommended", "evidence": [ { "id": "Q56JV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV9/entry#names_and_taxonomy" } ] }, { "name": "40S ribosomal protein S3a", "type": "synonym", "evidence": [ { "id": "NP_001029210", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029210" }, { "id": "Q56JV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JV9/entry#names_and_taxonomy" } ] }, { "name": "Ribosomal protein S3Ae", "type": "synonym", "evidence": [ { "id": "NP_001029210", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029210" } ] }, { "name": "small ribosomal subunit protein eS1", "type": "synonym", "evidence": [ { "id": "NP_001029210", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029210" } ] } ], "function": [ { "annotation": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q56JV9", "url": "https://www.uniprot.org/uniprotkb/Q56JV9#function" }, { "database": "UniProtKB", "id": "P61247", "url": "https://www.uniprot.org/uniprotkb/P61247#function" }, { "database": "HAMAP", "id": "MF_03122", "url": "https://hamap.expasy.org/signature/MF_03122" } ] }, { "annotation": "May play a role during erythropoiesis through regulation of transcription factor DDIT3.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9F0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9F0#function" }, { "database": "HAMAP", "id": "MF_03122", "url": "https://hamap.expasy.org/signature/MF_03122" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q56JV9", "url": "https://www.uniprot.org/uniprotkb/Q56JV9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPS3A", "url": "https://www.uniprot.org/uniprotkb/Q56JV9", "locus": { "chromosome": "17", "start_pos": 6717402, "end_pos": 6722090, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009908", "url": "https://www.ensembl.org/id/ENSBTAG00000009908" } ] } } ], "crossref": [ { "id": "Q56JV9", "url": "https://alphafold.ebi.ac.uk/entry/Q56JV9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009908", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009908", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "282053", "url": "https://www.ncbi.nlm.nih.gov/gene/282053", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018281", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018281", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282053", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282053", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TRFKGHE", "url": "https://omabrowser.org/oma/group/TRFKGHE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q56JV9", "url": "https://www.orthodb.org/?gene=Q56JV9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11830", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11830", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01015", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01015", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029210", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T9F0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9F0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9F0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9F0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JV9", "url": "https://www.uniprot.org/uniprotkb/Q56JV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JV9-1", "url": "https://www.uniprot.org/uniprotkb/Q56JV9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVGKNKRLTKGGKKGAKKKVVDPFSKKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRNNQIRKTSYAQHQQVRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKACQSIYPLHDVFVRKVKMLKKPKFELGKLMELHGEGSSSGKATGDETGAKVERADGYEPPVQESV", "length": 264, "header": "sp|Q56JV9-1|RS3A_BOVIN Isoform 1 of Small ribosomal subunit protein eS1 OS=Bos taurus OX=9913 GN=RPS3A PE=2 SV=3 CANONICAL=Q56JV9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T9F0-1", "url": "https://www.uniprot.org/uniprotkb/Q56JV9/entry#A0AAA9T9F0-1", "sequence": { "sequence": "MSKTLLWFIQDPASLRCLGRVEAGSFLVDPFSKKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRNNQIRKTSYAQHQQVRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKACQSIYPLHDVFVRKVKMLKKPKFELGKLMELHGEGSSSGKATGDETGAKVERADGYEPPVQESV", "length": 270, "header": "tr|A0AAA9T9F0-1|RS3A_BOVIN Computationally mapped isoform of Small ribosomal subunit protein eS1 OS=Bos taurus OX=9913 GN=RPS3A PE=2 SV=1 CANONICAL=Q56JV9-1" }, "locus": { "chromosome": "17", "start_pos": 6721703, "end_pos": 6717450, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120936.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120936.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095326.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095326.1" } ] } }, { "isoform_ac": "Q56JV9-1", "url": "https://www.uniprot.org/uniprotkb/Q56JV9/entry#Q56JV9-1", "sequence": { "sequence": "MAVGKNKRLTKGGKKGAKKKVVDPFSKKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRNNQIRKTSYAQHQQVRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKACQSIYPLHDVFVRKVKMLKKPKFELGKLMELHGEGSSSGKATGDETGAKVERADGYEPPVQESV", "length": 264, "header": "sp|Q56JV9-1|RS3A_BOVIN Isoform 1 of Small ribosomal subunit protein eS1 OS=Bos taurus OX=9913 GN=RPS3A PE=2 SV=3 CANONICAL=Q56JV9-1" }, "locus": { "chromosome": "17", "start_pos": 6722064, "end_pos": 6717450, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013079.4", "url": "https://www.ensembl.org/id/ENSBTAT00000013079.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013079.2", "url": "https://www.ensembl.org/id/ENSBTAP00000013079.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 236, "end_pos": 236, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q56JV9", "url": "https://www.uniprot.org/uniprotkb/Q56JV9" } ], "site_lbl": "Ser236" }, { "start_pos": 237, "end_pos": 237, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q56JV9", "url": "https://www.uniprot.org/uniprotkb/Q56JV9" } ], "site_lbl": "Ser237" }, { "start_pos": 256, "end_pos": 256, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q56JV9", "url": "https://www.uniprot.org/uniprotkb/Q56JV9" } ], "site_lbl": "Tyr256" }, { "start_pos": 263, "end_pos": 263, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q56JV9", "url": "https://www.uniprot.org/uniprotkb/Q56JV9" } ], "site_lbl": "Ser263" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:282053", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282053", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72649", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "resource": "Reactome", "description": "Translation initiation complex formation" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "resource": "Reactome", "description": "Formation of the ternary complex, and subsequently, the 43S complex" }, { "id": "R-BTA-72702", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "resource": "Reactome", "description": "Ribosomal scanning and start codon recognition" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1SK65-1", "protein_name": "Small ribosomal subunit protein eS1", "gene_name": "RPS3A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAVGKNKRLTKGGKKGAKKKVVDPFSKKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRNNQIRKTSYAQHQQVRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKACQSIYPLHDVFVRKVKMLKKPKFELGKLMELHGEGSSSGKATGDETGAKVERADGYEPPVQESV", "length": 264 }, "evidence": [ { "id": "Q56JV9", "url": "https://omabrowser.org/oma/group/Q56JV9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HKG8-1", "protein_name": "Small ribosomal subunit protein eS1", "gene_name": "Rps3a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAVGKNKRLTKGGKKGAKKKVVDPFSKKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRNNQIRKTSYAQHQQVRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKACQSIYPLHDVFVRKVKMLKKPKFELGKLMELHGEGGSSGKTTGDETGAKVERADGYEPPVQESV", "length": 264 }, "evidence": [ { "id": "Q56JV9", "url": "https://omabrowser.org/oma/group/Q56JV9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P23248-1", "protein_name": "Small ribosomal subunit protein eS1B", "gene_name": "RPS1B", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAVGKNKRLSRGKKGLKKKVVDPFTRKEWFDIKAPSTFENRNVGKTLVNKSTGLKNASDALKGRVVEVCLADLQGSEDHSFRKVKLRVDEVQGKNLLTNFHGMDFTTDKLRSMVRKWQTLIEANVTVKTSDDYVLRIFAIAFTRKQANQVKRHSYAQSSHIRAIRKVISEILTREVQNSTLAQLTSKLIPEVINKEIENATKDIFPLQNIHVRKVKLLKQPKFDVGALMALHGEGSGEEKGKKVSGFKDEVLETV", "length": 255 }, "evidence": [ { "id": "Q56JV9", "url": "https://omabrowser.org/oma/group/Q56JV9/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P49242-1", "protein_name": "Small ribosomal subunit protein eS1", "gene_name": "Rps3a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAVGKNKRLTKGGKKGAKKKVVDPFSKKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRNNQIRKTSYAQHQQVRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKACQSIYPLHDVFVRKVKMLKKPKFELGKLMELHGEGGSSGKTTGDETGAKVERADGYEPPVQESV", "length": 264 }, "evidence": [ { "id": "Q56JV9", "url": "https://omabrowser.org/oma/group/Q56JV9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P55830-1", "protein_name": "Small ribosomal subunit protein eS1", "gene_name": "RpS3A", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAVGKNKGLSKGGKKGGKKKVVDPFSRKDWYDVKAPNMFQTRQIGKTLVNRTQGQRIASDYLKGRVFEVSLADLQKDIDPERSFRKFRLIAEDVQDRNVLCNFHGMDLTTDKYRSMVKKWQTLIEAIVEAKTVDGYLLRVFCIGFTAKDQQSQRKTCYAQQSQVRKIRARMTDIITNEVSGADLKQLVNKLALDSIAKDIEKSCQRIYPLHDVYIRKVKVLKKPRFDVSKLLELHGDGGGKSVEAVVSSEGAVIDRPEGYEPPVQEAV", "length": 268 }, "evidence": [ { "id": "Q56JV9", "url": "https://omabrowser.org/oma/group/Q56JV9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P61247-1", "protein_name": "Small ribosomal subunit protein eS1", "gene_name": "RPS3A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAVGKNKRLTKGGKKGAKKKVVDPFSKKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRNNQIRKTSYAQHQQVRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKACQSIYPLHDVFVRKVKMLKKPKFELGKLMELHGEGSSSGKATGDETGAKVERADGYEPPVQESV", "length": 264 }, "evidence": [ { "id": "Q56JV9", "url": "https://omabrowser.org/oma/group/Q56JV9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P97351-1", "protein_name": "Small ribosomal subunit protein eS1", "gene_name": "Rps3a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAVGKNKRLTKGGKKGAKKKVVDPFSKKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRNNQIRKTSYAQHQQVRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKACQSIYPLHDVFVRKVKMLKKPKFELGKLMELHGEGGSSGKAAGDETGAKVERADGYEPPVQESV", "length": 264 }, "evidence": [ { "id": "Q56JV9", "url": "https://omabrowser.org/oma/group/Q56JV9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54ZW5-1", "protein_name": "Small ribosomal subunit protein eS1", "gene_name": "rps3a", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MADKKKKGSKKGGKKVDPFTRKEWYVVRAPTQFFKSPADNKVGFTPVNRTQGTKLASDGLKGRVYEVSLADMKDDESQVFRKIKLRAEEVEGRNVLTNFYGMDLTSDKLRSLIHKWSTLIECFVDVKTTDGYFLRVFAICFTKKGESQKKKTSYAKTSRVKAIRKKMVDILTETVSSNDLKTVVDYLIGVSLNGVTTNASGFAPTLAEKIRIEGSSIFPIHNVFIRKVKVLKTPKVDAAKLSELYASSATSTIAPTEEVGTAVERTEETTTTA", "length": 273 }, "evidence": [ { "id": "Q56JV9", "url": "https://omabrowser.org/oma/group/Q56JV9/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6PBY1-1", "protein_name": "Small ribosomal subunit protein eS1", "gene_name": "rps3a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAVGKNKRLTKGGKKGAKKKIVDPFSKKDWYDVKAPAMFNIRNLGKTLVTRTQGTRIASDGLKGRVFEVSLADLQNDEVAFRKFKLVTEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRTNQIRKTSYAQHQQVRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSVGKDIEKACQSIYPLHDVYVRKVKMLKKPKFELGKLMELHGEGGSTSAAAKPAEGDTGAKVERADGYEPPIQESV", "length": 267 }, "evidence": [ { "id": "Q56JV9", "url": "https://omabrowser.org/oma/group/Q56JV9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9CAV0-1", "protein_name": "Small ribosomal subunit protein eS1z", "gene_name": "RPS3AA", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAVGKNKRISKGRKGGKKKAVDPFSKKDWYDVKAPSIFTHRNVGKTLVSRTQGTKIASEGLKHRVFEVSLADLQGDEDNAYRKIRLRAEDVQGRNVLCQFWGMDFTTDKLRSLVKKWQTLIEAHVDVKTTDSYTLRLFCIAFTKRRANQVKRTCYAQSSQIRQIRRKMRDIMVREASSCDLKDLVAKFIPEAIGREIEKATQGIYPLQNVFIRKVKILKAPKFDLGKLMDVHGDYSAEDVGVKVDRPADEMAVEEPTEIIGA", "length": 262 }, "evidence": [ { "id": "Q56JV9", "url": "https://omabrowser.org/oma/group/Q56JV9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q56JV9", "url": "https://www.uniprot.org/uniprotkb/Q56JV9" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q56JV9", "url": "https://www.uniprot.org/uniprotkb/Q56JV9" } ], "pmid": "" }, { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "Q56JV9", "url": "https://www.uniprot.org/uniprotkb/Q56JV9" } ], "pmid": "" }, { "name": "cytosolic small ribosomal subunit", "id": "GO:0022627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022627", "evidence": [ { "database": "UniProtKB", "id": "Q56JV9", "url": "https://www.uniprot.org/uniprotkb/Q56JV9" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q56JV9", "url": "https://www.uniprot.org/uniprotkb/Q56JV9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q56JV9", "url": "https://www.uniprot.org/uniprotkb/Q56JV9" } ], "pmid": "" }, { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q56JV9", "url": "https://www.uniprot.org/uniprotkb/Q56JV9" } ], "pmid": "" }, { "name": "ribosomal small subunit biogenesis", "id": "GO:0042274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042274", "evidence": [ { "database": "UniProtKB", "id": "Q56JV9", "url": "https://www.uniprot.org/uniprotkb/Q56JV9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q56JV9", "url": "https://www.uniprot.org/uniprotkb/Q56JV9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q56JV9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 264, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q56JV9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q56JV9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 236, 237, 256, 263 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBI6-1", "uniprot_ac": "Q3ZBI6", "uniprot_id": "FHL3_BOVIN", "mass": { "chemical_mass": 31182.0, "monoisotopic_mass": 31182.0 }, "refseq": { "ac": "NP_001029395", "name": "four and a half LIM domains protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029395" }, "gene_names": [ { "name": "FHL3", "type": "recommended", "evidence": [ { "id": "Q3ZBI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI6" } ] }, { "name": "FHL3", "type": "synonym", "evidence": [ { "id": "NP_001029395", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029395" } ] } ], "protein_names": [ { "name": "Four and a half LIM domains protein 3", "type": "recommended", "evidence": [ { "id": "Q3ZBI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI6/entry#names_and_taxonomy" } ] }, { "name": "FHL-3", "type": "synonym", "evidence": [ { "id": "NP_001029395", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029395" }, { "id": "Q3ZBI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI6/entry#names_and_taxonomy" } ] }, { "name": "four and a half LIM domains protein 3", "type": "synonym", "evidence": [ { "id": "NP_001029395", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029395" } ] } ], "function": [ { "annotation": "Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI6#function" }, { "database": "UniProtKB", "id": "Q9R059", "url": "https://www.uniprot.org/uniprotkb/Q9R059#function" }, { "database": "UniProtKB", "id": "A0AAA9TEH7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEH7#function" }, { "database": "UniProtKB", "id": "ARBA00054878", "url": "https://www.uniprot.org/uniprotkb/ARBA00054878#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBI6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FHL3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI6", "locus": { "chromosome": "3", "start_pos": 107967690, "end_pos": 107959498, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007300", "url": "https://www.ensembl.org/id/ENSBTAG00000007300" } ] } } ], "crossref": [ { "id": "Q3ZBI6", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBI6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007300", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007300", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09346", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09346", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09423", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09423", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09427", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09427", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09434", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09434", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504795", "url": "https://www.ncbi.nlm.nih.gov/gene/504795", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056807", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056807", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504795", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504795", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QWHQTCF", "url": "https://omabrowser.org/oma/group/QWHQTCF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBI6", "url": "https://www.orthodb.org/?gene=Q3ZBI6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24205", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24205", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24205:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24205:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029395", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TEH7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEH7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEH7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEH7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBI6", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBI6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEAFDCAKCSESLYGRKYIQTDDGPYCVPCYDNTFANTCAECQQLIGHDSRELFYEDRHFHEGCFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSSQCSACGETVMPGSRKLEYGGQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFAPRCARCSKTLTQGGVTYRDQPWHRECLVCTGCQTPLAGQQFTSREDDPYCVTCFGELFAPKCSSCKRPITGLGGGKYVSFEDRHWHHSCFSCARCSTSLVGQGFVPDGDQVLCQGCSQAGP", "length": 280, "header": "sp|Q3ZBI6-1|FHL3_BOVIN Isoform 1 of Four and a half LIM domains protein 3 OS=Bos taurus OX=9913 GN=FHL3 PE=2 SV=1 CANONICAL=Q3ZBI6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TEH7-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI6/entry#A0AAA9TEH7-1", "sequence": { "sequence": "MSEAFDCAKCSESLYGRKYIQTDDGPYCVPCYDNTFANTCAECQQLIGHDSRELFYEDRHFHEGCFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSSQCSACGETVMPGSRKLEYGGQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFAPRCARCSKTLTQGGVTYRDQPWHRECLVCTGCQTPLAGQQFTSREDDPYCVTCFGELFAPKCSSCKRPITGLGGGKYVSFEDRHWHHSCFSCARCSTSLD", "length": 259, "header": "tr|A0AAA9TEH7-1|FHL3_BOVIN Computationally mapped isoform of Four and a half LIM domains protein 3 OS=Bos taurus OX=9913 GN=FHL3 PE=2 SV=1 CANONICAL=Q3ZBI6-1" }, "locus": { "chromosome": "3", "start_pos": 107967560, "end_pos": 107964545, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113804.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113804.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095339.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095339.1" } ] } }, { "isoform_ac": "Q3ZBI6-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBI6/entry#Q3ZBI6-1", "sequence": { "sequence": "MSEAFDCAKCSESLYGRKYIQTDDGPYCVPCYDNTFANTCAECQQLIGHDSRELFYEDRHFHEGCFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSSQCSACGETVMPGSRKLEYGGQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFAPRCARCSKTLTQGGVTYRDQPWHRECLVCTGCQTPLAGQQFTSREDDPYCVTCFGELFAPKCSSCKRPITGLGGGKYVSFEDRHWHHSCFSCARCSTSLVGQGFVPDGDQVLCQGCSQAGP", "length": 280, "header": "sp|Q3ZBI6-1|FHL3_BOVIN Isoform 1 of Four and a half LIM domains protein 3 OS=Bos taurus OX=9913 GN=FHL3 PE=2 SV=1 CANONICAL=Q3ZBI6-1" }, "locus": { "chromosome": "3", "start_pos": 107966532, "end_pos": 107964545, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009604.6", "url": "https://www.ensembl.org/id/ENSBTAT00000009604.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009604.3", "url": "https://www.ensembl.org/id/ENSBTAP00000009604.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504795", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504795", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6A1C9-1", "protein_name": "Four and a half LIM domains protein 3", "gene_name": "Fhl3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSEAFDCAKCNESLYGRKYIQTDSGPYCVPCYDNTFANTCAECQQLIGHDSRELFYEDRHFHEGCFRCCRCQRSLADEPFTCQDSELLCNECYCTAFSSQCSACGETVMPGSRKLEYGGQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFAPRCARCSKTLTQGGVTYRDQPWHRECLVCTGCQTPLAGQQFTSRDDDPYCVACFGELFAPKCSSCKRPITGGSGSEGAGKSADVILGEPKGQQCPQTCRANLQPSSRTRWRQVRVLRRPTLAPQLLFLCPLLHLPGGPRLCTRWRPSSVPGLQPSRPLSPGS", "length": 321 }, "evidence": [ { "id": "Q3ZBI6", "url": "https://omabrowser.org/oma/group/Q3ZBI6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A9J7FF68-1", "protein_name": "Four and a half LIM domains protein 3", "gene_name": "Fhl3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSPYLNSYGHPGNEEGLLSITTMSEAFDCAKCSESLYGRKYIQTDSGPYCVPCYDNTFANTCAECQQLIGHDSRELFYEDRHFHEGCFRCCRCQRSLADEPFTCQDSELLCNDCYCTAFSSQCSACGETVMPGSRKLEYGGQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFAPRCARCSKTLTQGGVTYRDQPWHRECLVCTGCKTPLAGQQFTSRDDDPYCVACFGELFAPKCSSCKRPITGGSSGEAAGGGKYVSFEDRHWHHSCFSCARCSTSLVGQGFVPDGDQVLCQGCSQAGP", "length": 308 }, "evidence": [ { "id": "Q3ZBI6", "url": "https://omabrowser.org/oma/group/Q3ZBI6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E7EZP9-1", "protein_name": "Four and a half LIM domains protein 3", "gene_name": "fhl3a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSERFDCDNCKESLYGRKYIQAEENPYCIPCYDSLFANTCDECKELIGHDSRELFYEDRHYHEHCFRCFRCDRSLADEPFTSQDDALLCNDCYCNEFSSKCVACDKTVMPGTRKLEYAGSTWHEGCFICNSCQQPIGSKSFIPDKDDHYCVPCYENKFAPRCTRCKQALAKGGVTYRDEPWHKECFVCTSCKVQLAGQHFTSRDDSPYCIKCFGNLYAKKCEACNKPITGFGGGKYISFEDRQWHQPCFTCSRCSVSLVGAGFFPEQDEILCRNCNSTL", "length": 279 }, "evidence": [ { "id": "Q3ZBI6", "url": "https://omabrowser.org/oma/group/Q3ZBI6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q13643-1", "protein_name": "Four and a half LIM domains protein 3", "gene_name": "FHL3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSESFDCAKCNESLYGRKYIQTDSGPYCVPCYDNTFANTCAECQQLIGHDSRELFYEDRHFHEGCFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSSQCSACGETVMPGSRKLEYGGQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFAPRCARCSKTLTQGGVTYRDQPWHRECLVCTGCQTPLAGQQFTSRDEDPYCVACFGELFAPKCSSCKRPIVGLGGGKYVSFEDRHWHHNCFSCARCSTSLVGQGFVPDGDQVLCQGCSQAGP", "length": 280 }, "evidence": [ { "id": "Q3ZBI6", "url": "https://omabrowser.org/oma/group/Q3ZBI6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9R059-1", "protein_name": "Four and a half LIM domains protein 3", "gene_name": "Fhl3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-200425", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-200425", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029521", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029521", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "12661", "url": "https://www.rhea-db.org/rhea/12661", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9THF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THF6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THF6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DK1", "url": "https://www.uniprot.org/uniprotkb/Q58DK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DK1-1", "url": "https://www.uniprot.org/uniprotkb/Q58DK1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEAHQAVAFQFTVTPEGVDFQLSREVLKHIYLSVIRSWKKRLIRIKNGILRGVYPGSPTSWLVVVMATAGSSYYNVDISMGLVYYIQRWLPEGRPYRTPYTRTLFSMAIFSTGVWMMGIFFFRQTLKLLLSYHGWMFELHGQTSHLTRVWAVCVRLLSGRRPMLYSFQTSLPKLPVPSVPATVHRYLESVEHLLDDEQYYRMETLAKEFEEKTAPRLQKYLVLKSWWATNYVSDWWEEYVYLRGRNPIVVNSNYYVMDLVLVKNTDVQAARLGNAVHAMITYRRKLDREEIKPVMALGLVPMCSYQMERMFNTTRIPGKDTDVLQHLPDSRHVAVYHKGRFFKVWLYEGSRLLKPRDLEMQFQRILDDPSPPQPGEERLAALTAGGRVEWAQARQAFFSSGKNKAALDAIERAAFFVALDEESHHYDPEDEASLSLYGKALLHGNCYNRWFDKSFTLISFKNGQLGLNTEHAWADAPIIGHLWEFVLGTDSFHLGYTETGHCLGKPNPVLPPPQRLQWDIPKQCQAVIESSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDRGKFCLTYEASMTRMFREGRTETVRSCTRESTAFVQAMVQGRHLNEDLQRLFRKAAEKHQNMYRLAMTGAGIDRHLFCLYVVSKYLGVESPFLAEVLSEPWRLSTSQIAQFQIRMFDPNKYPKHLGAGGGFGPVADDGYGVSYMIAGENTIFFHVSSKFSSSETNAQRFGNQIRQALLDIANLFQVPKADG", "length": 771, "header": "sp|Q58DK1-1|CPT1B_BOVIN Isoform 1 of Carnitine O-palmitoyltransferase 1, muscle isoform OS=Bos taurus OX=9913 GN=CPT1B PE=2 SV=1 CANONICAL=Q58DK1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9THF6-1", "url": "https://www.uniprot.org/uniprotkb/Q58DK1/entry#A0AAA9THF6-1", "sequence": { "sequence": "MAEAHQAVAFQFTVTPEGVDFQLSREVLKHIYLSVIRSWKKRLIRIKNGILRGVYPGSPTSWLVVVMATAGSSYYNVDISMGLVYYIQRWLPEGRPYRTPYTRTLFSMAIFSTGVWMMGIFFFRQTLKLLLSYHGWMFELHGQTSHLTRVWAVCVRLLSGRRPMLYSFQTSLPKLPVPSVPATVHRYLESVEHLLDDEQYYRMETLAKEFEEKTAPRLQKYLVLKSWWATNYVSDWWEEYVYLRGRNPIVVNSNYYVMDLVLVKNTDVQAARLGNAVHAMITYRRKLDREEIKPVMALGLVPMCSYQMERMFNTTRIPGKDTDVLQHLPDSRHVAVYHKGRFFKVWLYEGSRLLKPRDLEMQFQRILDDPSPPQPGEERLAALTAGGRVEWAQARQAFFSSGKNKAALDAIERAAFFVALDEESHHYDPEDEASLSLYGKALLHGNCYNRWFDKSFTLISFKNGQLGLNTEHAWADAPIIGHLWEFVLGTDSFHLGYTETGHCLGKPNPVLPPPQRLQWDIPKQPSGLLDMTPESCWRALPPADPSVSWQCQAVIESSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDRGKFCLTYEASMTRMFREGRTETVRSCTRESTAFVQAMVQGRHLVSPRGLVLATARPLRVRGQTYSSRPCFCPQNEDLQRLFRKAAEKHQNMYRLAMTGAGIDRHLFCLYVVSKYLGVESPFLAEVSVDGHVCPQARSRWLCLLHAPPRPVDWPRAAAFPLARGCWREWGWTDKRDMSGGGSAHEGNAEAQGDWGVRAEGAFSAQTATKAVAWDKEEQLGVRVEAGAGQAGPMMEGSVQML", "length": 847, "header": "tr|A0AAA9THF6-1|CPT1B_BOVIN Computationally mapped isoform of Carnitine O-palmitoyltransferase 1, muscle isoform OS=Bos taurus OX=9913 GN=CPT1B PE=2 SV=2 CANONICAL=Q58DK1-1" }, "locus": { "chromosome": "5", "start_pos": 119896400, "end_pos": 119890319, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136013.2", "url": "https://www.ensembl.org/id/ENSBTAT00000136013.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097954.2", "url": "https://www.ensembl.org/id/ENSBTAP00000097954.2" } ] } }, { "isoform_ac": "A0AAA9TYJ3-1", "url": "https://www.uniprot.org/uniprotkb/Q58DK1/entry#A0AAA9TYJ3-1", "sequence": { "sequence": "MAEAHQAVAFQFTVTPEGVDFQLSREVLKHIYLSVIRSWKKRLIRIKNGILRGVYPGSPTSWLVVVMATAGSSYYNVDISMGLVYYIQRWLPEGRPYRTPYTRTLFSMAIFSTGVWMMGIFFFRQTLKLLLSYHGWMFELHGQTSHLTRVWAYLESVEHLLDDEQYYRMETLAKEFEEKTAPRLQKYLVLKSWWATNYVSDWWEEYVYLRGRNPIVVNSNYYVMDLVLVKNTDVQAARLGNAVHAMITYRRKLDREEIKPVMALGLVPMCSYQMERMFNTTRIPGKDTDVLQHLPDSRHVAVYHKGRFFKVWLYEGSRLLKPRDLEMQFQRILDDPSPPQPGEERLAALTAGGRVEWAQARQAFFSSGKNKAALDAIERAAFFVALDEESHHYDPEDEASLSLYGKALLHGNCYNRWFDKSFTLISFKNGQLGLNTEHAWADAPIIGHLWEFVLGTDSFHLGYTETGHCLGKPNPVLPPPQRLQWDIPKQCQAVIESSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDRGKFCLTYEASMTRMFREGRTETVRSCTRESTAFVQAMVQGRHLNEDLQRLFRKAAEKHQNMYRLAMTGAGIDRHLFCLYVVSKYLGVESPFLAEVLSEPWRLSTSQIAQFQIRMFDPNKYPKHLGAGGGFGPVADDGYGVSYMIAGENTIFFHVSSKFSSSETNAQRFGNQIRQALLDIANLFQVPKADG", "length": 737, "header": "tr|A0AAA9TYJ3-1|CPT1B_BOVIN Computationally mapped isoform of Carnitine O-palmitoyltransferase 1, muscle isoform OS=Bos taurus OX=9913 GN=CPT1B PE=2 SV=1 CANONICAL=Q58DK1-1" }, "locus": { "chromosome": "5", "start_pos": 119896400, "end_pos": 119889186, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110005.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110005.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102304.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102304.1" } ] } }, { "isoform_ac": "Q58DK1-1", "url": "https://www.uniprot.org/uniprotkb/Q58DK1/entry#Q58DK1-1", "sequence": { "sequence": "MAEAHQAVAFQFTVTPEGVDFQLSREVLKHIYLSVIRSWKKRLIRIKNGILRGVYPGSPTSWLVVVMATAGSSYYNVDISMGLVYYIQRWLPEGRPYRTPYTRTLFSMAIFSTGVWMMGIFFFRQTLKLLLSYHGWMFELHGQTSHLTRVWAVCVRLLSGRRPMLYSFQTSLPKLPVPSVPATVHRYLESVEHLLDDEQYYRMETLAKEFEEKTAPRLQKYLVLKSWWATNYVSDWWEEYVYLRGRNPIVVNSNYYVMDLVLVKNTDVQAARLGNAVHAMITYRRKLDREEIKPVMALGLVPMCSYQMERMFNTTRIPGKDTDVLQHLPDSRHVAVYHKGRFFKVWLYEGSRLLKPRDLEMQFQRILDDPSPPQPGEERLAALTAGGRVEWAQARQAFFSSGKNKAALDAIERAAFFVALDEESHHYDPEDEASLSLYGKALLHGNCYNRWFDKSFTLISFKNGQLGLNTEHAWADAPIIGHLWEFVLGTDSFHLGYTETGHCLGKPNPVLPPPQRLQWDIPKQCQAVIESSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDRGKFCLTYEASMTRMFREGRTETVRSCTRESTAFVQAMVQGRHLNEDLQRLFRKAAEKHQNMYRLAMTGAGIDRHLFCLYVVSKYLGVESPFLAEVLSEPWRLSTSQIAQFQIRMFDPNKYPKHLGAGGGFGPVADDGYGVSYMIAGENTIFFHVSSKFSSSETNAQRFGNQIRQALLDIANLFQVPKADG", "length": 771, "header": "sp|Q58DK1-1|CPT1B_BOVIN Isoform 1 of Carnitine O-palmitoyltransferase 1, muscle isoform OS=Bos taurus OX=9913 GN=CPT1B PE=2 SV=1 CANONICAL=Q58DK1-1" }, "locus": { "chromosome": "5", "start_pos": 119896400, "end_pos": 119889186, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021357.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021357.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021357.4", "url": "https://www.ensembl.org/id/ENSBTAP00000021357.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DK1", "url": "https://www.uniprot.org/uniprotkb/Q58DK1" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "Effect of NEFA and glucose levels on CPT-I mRNA expression and translation in cultured bovine hepatocytes.", "journal": "The Journal of veterinary medical science", "date": "2011-01", "authors": "Xu Chuang, Wang Zhe, Zhang Ri-He, Zhang Hong-You, Fu Shi-Xin, Xia Cheng", "evidence": [ { "database": "RefSeq", "id": "NP_001029521", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029521" } ], "reference": [ { "type": "PubMed", "id": "20716862", "url": "https://glygen.org/publication/PubMed/20716862" } ] }, { "title": "Abomasal infusion of arginine stimulates SCD and C/EBP\u00df gene expression, and decreases CPT1\u00df gene expression in bovine adipose tissue independent of conjugated linoleic acid.", "journal": "Amino acids", "date": "2014-02", "authors": "Choi Seong Ho, Wickersham Tryon A, Wu Guoyao, Gilmore L Anne, Edwards Holly D, Park Sung Kwon, Kim Kyoung Hoon, Smith Stephen B", "evidence": [ { "database": "RefSeq", "id": "NP_001029521", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029521" } ], "reference": [ { "type": "PubMed", "id": "24327170", "url": "https://glygen.org/publication/PubMed/24327170" } ] }, { "title": "The PPAR\u03b4 Agonist GW501516 Improves Lipolytic/Lipogenic Balance through CPT1 and PEPCK during the Development of Pre-Implantation Bovine Embryos.", "journal": "International journal of molecular sciences", "date": "2019-12-02", "authors": "Idrees Muhammad, Xu Lianguang, El Sheikh Marwa, Sidrat Tabinda, Song Seok-Hwan, Joo Myeong-Don, Lee Kyeong-Lim, Kong Il-Keun", "evidence": [ { "database": "RefSeq", "id": "NP_001029521", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029521" } ], "reference": [ { "type": "PubMed", "id": "31810173", "url": "https://glygen.org/publication/PubMed/31810173" } ] } ], "pathway": [ { "id": "bta:509459", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509459", "resource": "KEGG Pathway" }, { "id": "R-BTA-200425", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-200425", "resource": "Reactome", "description": "Carnitine shuttle" } ], "orthologs": [ { "uniprot_canonical_ac": "F6P7Z9-1", "protein_name": "Carnitine O-palmitoyltransferase 1, muscle isoform", "gene_name": "cpt1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAEAHQAVAFQFTVTPDGIDLQLSREVLKHIYISGVTSWKKRAIRFKNSVLTGVYPASPSSWLFVVIAIMSTMYARIDPSMGTIDKIKTSLPVSEFMTVQTQTVLSAILFATGLWLSVIFLLRYLLKALLSYHAWIFESHGKMSYSTKVWLSLVKLLSGRRPLLYSFQGSLPHLPVPSIDDTIRRYLESVRPLLDDEQYKQMETVANDFKKDPAPKLQKHLKLKSWWATNYVSDWWEEYIYLRGRDPIMVNSNFYTMDLLYVIPTYRQAARAGNVVHAMLQYRRKLERGELTPLRALGIVPMCSFQYERMFNTTRIPGIETDFVQHLKDRKHLVVYHRGRLFKVWLYYGGRHLWPSELELQFQRILDDKSEPQPGELKLPSLTAGNRVPWARARLKYFGEGVNRASLEAIETAAFFLTLDDEAHGYDPENIRSLDLYAKSLLHGKCYDRWFDKSFNLIVYKNGKMGVNTEHSWADSPIIGHMWEYVLATDCFHLGYTAEGHCKGDVNKTLAPPTRLQWDIPKACQEIIEGSYRIAKGIADDVDFHGCLFNEFGKGLIKKCRTSPDAFIQLALQLAQYRDKGEFCLTYESSMTRMFREGRTETVRSCTCESTAFVRAMEDDTTTNEQRLALFKQAAEKHQNMYRLAMTGAGIDRHLFCLYIVSKVMGIDSPFLKQVLSEPWRLSTSQTPQQQLNLIDTQKFPKYVSAGGGFGPVADDGYGVSYIIVGENLITFHISSKFSSPETDSFRFGQNIRQAMQDIRALFNQKEKKM", "length": 770 }, "evidence": [ { "id": "Q58DK1", "url": "https://omabrowser.org/oma/group/Q58DK1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q63704-1", "protein_name": "Carnitine O-palmitoyltransferase 1, muscle isoform", "gene_name": "Cpt1b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEAHQAVAFQFTVTPDGVDFRLSREALRHIYLSGINSWKKRLIRIKNGILRGVYPGSPTSWLVVVMATVGSNYCKVDISMGLVHCIQRCLPTRYGSYGTPQTETLLSMVIFSTGVWATGIFLFRQTLKLLLSYHGWMFEMHSKTSHATKIWAICVRLLSSRRPMLYSFQTSLPKLPVPSVPATIHRYLDSVRPLLDDEAYFRMESLAKEFQDKIAPRLQKYLVLKSWWATNYVSDWWEEYVYLRGRSPIMVNSNYYAMDFVLIKNTSQQAARLGNTVHAMIMYRRKLDREEIKPVMALGMVPMCSYQMERMFNTTRIPGKETDLLQHLSESRHVAVYHKGRFFKVWLYEGSCLLKPRDLEMQFQRILDDTSPPQPGEEKLAALTAGGRVEWAEARQKFFSSGKNKMSLDTIERAAFFVALDEDSHCYNPDDEASLSLYGKSLLHGNCYNRWFDKSFTLISCKNGQLGLNTEHSWADAPIIGHLWEFVLATDTFHLGYTETGHCVGEPNTKLPPPQRMQWDIPEQCQTAIENSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDKGKFCLTYEASMTRMFREGRTETVRSCTSESTAFVRAMMTGSHKKQDLQDLFRKASEKHQNMYRLAMTGAGIDRHLFCLYIVSKYLGVRSPFLDEVLSEPWSLSTSQIPQFQICMFDPKQYPNHLGAGGGFGPVADHGYGVSYMIAGENTMFFHVSSKLSSSETNALRFGNHIRQALLDIADLFKISKTDS", "length": 772 }, "evidence": [ { "id": "Q58DK1", "url": "https://omabrowser.org/oma/group/Q58DK1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q924X2-1", "protein_name": "Carnitine O-palmitoyltransferase 1, muscle isoform", "gene_name": "Cpt1b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEAHQAVAFQFTVTPDGVDFRLSREALRHIYLSGINSWKKRLIRIKNGILRGVYPGSPTSWLVVVMATVGSNYCKVDISMGLVDCIQRCLPERYGHFGTPQTEALLSMVIFSTGVWATGIFFFRQTLKLLLSYHGWMFEMHSKTSHATKIWAICVRLLSSRRPMLYSFQTSLPKLPVPSVPATIHRYLDSVRPLLDDEAYYRMETLAKEFQDKTAPRLQKYLVLKSWWATNYVSDWWEEYVYLRSRSPLMVNSNYYAMDFVLIKNTNVQAARLGNAVHAMIMYRRKLDREEIKPVMALGMVPMCSYQMERMFNTTRIPGKETDLLQHLSESRHVAVYHKGRFFKVWLYEGSRLLKPRDLEMQFQRILDDPSPPQPGEEKLAALTAGGRVEWAEARQTFFSSGKNKMSLDAIERAAFFVTLDEDSHCYNPDDETSLSLYGKALLHGNCYNRWFDKSFTLISCKNGLLGLNTEHSWADAPIIGHLWEFVLGTDTFHLGYTETGHCVGEPNTTLPPPQRLPWDIPEQCREAIENSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDKGKFCLTYEASMTRMFREGRTETVRSCTNESAAFVQAMMKGSHKKQDLQDLFRKASEKHQNMYRLAMTGAGIDRHLFCLYIVSKYLGVSSPFLAEVLSEPWSLSTSQIPQFQICMFDPKQYPNHLGAGGGFGPVADDGYGVSYMIAGENTMFFHISSKYSSSETNAQRFGNHIRQALLDIAELFKISKTDS", "length": 772 }, "evidence": [ { "id": "Q58DK1", "url": "https://omabrowser.org/oma/group/Q58DK1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "carnitine O-palmitoyltransferase activity", "id": "GO:0004095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004095", "evidence": [ { "database": "UniProtKB", "id": "Q58DK1", "url": "https://www.uniprot.org/uniprotkb/Q58DK1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q58DK1", "url": "https://www.uniprot.org/uniprotkb/Q58DK1" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "Q58DK1", "url": "https://www.uniprot.org/uniprotkb/Q58DK1" } ], "pmid": "" }, { "name": "mitochondrial intermembrane space", "id": "GO:0005758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005758", "evidence": [ { "database": "UniProtKB", "id": "Q58DK1", "url": "https://www.uniprot.org/uniprotkb/Q58DK1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "Q58DK1", "url": "https://www.uniprot.org/uniprotkb/Q58DK1" } ], "pmid": "" }, { "name": "fatty acid beta-oxidation", "id": "GO:0006635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006635", "evidence": [ { "database": "UniProtKB", "id": "Q58DK1", "url": "https://www.uniprot.org/uniprotkb/Q58DK1" } ], "pmid": "" }, { "name": "long-chain fatty acid transport", "id": "GO:0015909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015909", "evidence": [ { "database": "UniProtKB", "id": "Q58DK1", "url": "https://www.uniprot.org/uniprotkb/Q58DK1" } ], "pmid": "" }, { "name": "carnitine metabolic process", "id": "GO:0009437", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009437", "evidence": [ { "database": "UniProtKB", "id": "Q58DK1", "url": "https://www.uniprot.org/uniprotkb/Q58DK1" } ], "pmid": "" }, { "name": "response to blue light", "id": "GO:0009637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009637", "evidence": [ { "database": "UniProtKB", "id": "Q58DK1", "url": "https://www.uniprot.org/uniprotkb/Q58DK1" } ], "pmid": "" }, { "name": "carnitine shuttle", "id": "GO:0006853", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006853", "evidence": [ { "database": "UniProtKB", "id": "Q58DK1", "url": "https://www.uniprot.org/uniprotkb/Q58DK1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 313, "end_pos": 315, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12661", "name": "", "equation": "(R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KJB7-1", "F1N1M7-1", "Q58DK1-1", "A0A3Q1M507-1" ], "evidence": [ { "id": "12661", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12661" } ] }, { "id": "R-BTA-9911362", "name": "CPT1B transfers PALM to CAR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, mitochondrial intermembrane space, mitochondrial outer membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q58DK1-1" ], "evidence": [ { "id": "R-BTA-9911362", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9911362" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M507", "gene_name": "CPT1A", "activity": [ { "ec_number": "2.3.1.21", "activity": "(R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA.", "evidence": [ { "id": "A0A3Q1M507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M507" } ] }, { "ec_number": "2.3.1.21", "activity": "", "evidence": [ { "id": "A0A3Q1M507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M507" } ] } ] }, { "uniprot_ac": "F1N1M7", "gene_name": "CPT2", "activity": [ { "ec_number": 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Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T5", "url": "https://www.uniprot.org/uniprotkb/Q5E9T5#function" }, { "database": "UniProtKB", "id": "Q9D328", "url": "https://www.uniprot.org/uniprotkb/Q9D328#function" }, { "database": "UniProtKB", "id": "Q53FP2", "url": "https://www.uniprot.org/uniprotkb/Q53FP2#function" }, { "database": "UniProtKB", "id": "A0AAA9TIR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIR8#function" }, { "database": "UniProtKB", "id": "ARBA00046118", "url": "https://www.uniprot.org/uniprotkb/ARBA00046118#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9T5", "url": "https://www.uniprot.org/uniprotkb/Q5E9T5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM35A", "url": "https://www.uniprot.org/uniprotkb/Q5E9T5", "locus": { "chromosome": "X", "start_pos": 51064358, "end_pos": 51076888, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021252", "url": "https://www.ensembl.org/id/ENSBTAG00000021252" } ] } } ], "crossref": [ { "id": "Q5E9T5", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9T5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021252", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021252", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533337", "url": "https://www.ncbi.nlm.nih.gov/gene/533337", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR040399", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040399", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533337", "url": 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] }, { "id": "A0AAA9TIR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIR8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9T5", "url": "https://www.uniprot.org/uniprotkb/Q5E9T5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9T5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASPRTVTVVALSVALGLFFVFMGTIKLTPRLSKDAYSEMKRAYKSYVRALPLLKKMGINSILLRKSIGALEVACGIVMTLVPGRPKDVANFFLLLLVLAVLFFHQLVGDPLKRYAHALVFGILLTCRLLIARKPEDRSSEKKSSPPGNAGSDGNAGNTEEQPSLYEKAPQGKMKLS", "length": 177, "header": "sp|Q5E9T5-1|NACHO_BOVIN Isoform 1 of Novel acetylcholine receptor chaperone OS=Bos taurus OX=9913 GN=TMEM35A PE=2 SV=1 CANONICAL=Q5E9T5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TIR8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T5/entry#A0AAA9TIR8-1", "sequence": { "sequence": "MQFPLEKRRKERGNCCIQISTAAVPEKRAYKSYVRALPLLKKMGINSILLRKSIGALEVACGIVMTLVPGRPKDVANFFLLLLVLAVLFFHQLVGDPLKRYAHALVFGILLTCRLLIARKPEDRSSEKKSSPPGNAGSDGNAGNTEEQPSLYEKAPQGKMKLS", "length": 163, "header": "tr|A0AAA9TIR8-1|NACHO_BOVIN Computationally mapped isoform of Novel acetylcholine receptor chaperone OS=Bos taurus OX=9913 GN=TMEM35A PE=2 SV=1 CANONICAL=Q5E9T5-1" }, "locus": { "chromosome": "X", "start_pos": 51070259, "end_pos": 51065780, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096931.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096931.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096129.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096129.1" } ] } }, { "isoform_ac": "Q5E9T5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9T5/entry#Q5E9T5-1", "sequence": { "sequence": "MASPRTVTVVALSVALGLFFVFMGTIKLTPRLSKDAYSEMKRAYKSYVRALPLLKKMGINSILLRKSIGALEVACGIVMTLVPGRPKDVANFFLLLLVLAVLFFHQLVGDPLKRYAHALVFGILLTCRLLIARKPEDRSSEKKSSPPGNAGSDGNAGNTEEQPSLYEKAPQGKMKLS", "length": 177, "header": "sp|Q5E9T5-1|NACHO_BOVIN Isoform 1 of Novel acetylcholine receptor chaperone OS=Bos taurus OX=9913 GN=TMEM35A PE=2 SV=1 CANONICAL=Q5E9T5-1" }, "locus": { "chromosome": "X", "start_pos": 51076780, "end_pos": 51065780, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028319.5", "url": "https://www.ensembl.org/id/ENSBTAT00000028319.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028319.3", "url": "https://www.ensembl.org/id/ENSBTAP00000028319.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9T5", "url": "https://www.uniprot.org/uniprotkb/Q5E9T5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:533337", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533337", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "I3LKJ0-1", "protein_name": "Novel acetylcholine receptor chaperone", "gene_name": "TMEM35A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASPRTVTVVALSVALGLFFVFMGTIKLTPRLSKDAYNEMKRAYKSYVRALPLLKKMGINSILLRKSIGALEVACGIVMTLVPGRPKDVANFFLLLLVLAVLFFHQLVGDPLKRYAHALVFGILLTCRLLIARKPEDRSSEKKSSPPGNAGGATASNAGNTEEQPTLYEKAPQGKMKLS", "length": 179 }, "evidence": [ { "id": "Q5E9T5", "url": "https://omabrowser.org/oma/group/Q5E9T5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q53FP2-1", "protein_name": "Novel acetylcholine receptor chaperone", "gene_name": "TMEM35A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASPRTVTIVALSVALGLFFVFMGTIKLTPRLSKDAYSEMKRAYKSYVRALPLLKKMGINSILLRKSIGALEVACGIVMTLVPGRPKDVANFFLLLLVLAVLFFHQLVGDPLKRYAHALVFGILLTCRLLIARKPEDRSSEKKPLPGNAEEQPSLYEKAPQGKVKVS", "length": 167 }, "evidence": [ { "id": "Q5E9T5", "url": "https://omabrowser.org/oma/group/Q5E9T5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q58EL2-1", "protein_name": "Novel acetylcholine receptor chaperone", "gene_name": "tmem35a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MASPRTVTIVALSFALGLFFVFMGTIKLTPRLSKDAYSEMKRAYKSYAKALPALKKMGVSSVLLRKIIGTLEVGCGIVLTLVPGRPKDVANFILLLVMLAVLFFHQLVGDPLKRYAHALVFGILLTCRLLIARQAEDRPEREERREEQINAQEKNKVKVS", "length": 160 }, "evidence": [ { "id": "Q5E9T5", "url": 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], "protein_names": [ { "name": "U6 snRNA-associated Sm-like protein LSm1", "type": "recommended", "evidence": [ { "id": "Q5E9Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8/entry#names_and_taxonomy" } ] }, { "name": "LSM1 homolog, U6 small nuclear RNA associated", "type": "synonym", "evidence": [ { "id": "NP_001017952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017952" } ] }, { "name": "LSM1, U6 small nuclear RNA associated", "type": "synonym", "evidence": [ { "id": "NP_001017952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017952" } ] }, { "name": "U6 snRNA-associated Sm-like protein LSm1", "type": "synonym", "evidence": [ { "id": "NP_001017952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017952" } ] } ], "function": [ { "annotation": "Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z8", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8#function" }, { "database": "UniProtKB", "id": "O15116", "url": "https://www.uniprot.org/uniprotkb/O15116#function" }, { "database": "UniProtKB", "id": "P47017", "url": "https://www.uniprot.org/uniprotkb/P47017#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z8", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LSM1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8", "locus": { "chromosome": "27", "start_pos": 33337991, "end_pos": 33348726, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001612", "url": "https://www.ensembl.org/id/ENSBTAG00000001612" } ] } } ], "crossref": [ { "id": "Q5E9Z8", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9Z8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001612", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001612", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01728", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01728", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535447", "url": "https://www.ncbi.nlm.nih.gov/gene/535447", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001163", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010920", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010920", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034104", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034104", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044642", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044642", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047575", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047575", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535447", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535447", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IGYLRCV", "url": "https://omabrowser.org/oma/group/IGYLRCV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9Z8", "url": "https://www.orthodb.org/?gene=Q5E9Z8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15588", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15588", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15588:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15588:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01423", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01423", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-430039", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-430039", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001017952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017952", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TS05", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS05-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS05-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9Z8", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9Z8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNYMPGTASLIEDIDKKHLVLLRDGRTLIGFLRSIDQFANLVLHQTVERIHVGKKYGDIPRGIFVVRGENVVLLGEIDLEKESDTPLQQVSIEEILEEQRVEQQTKLEAEKLKVQALKDRGLSIPRADTLEEY", "length": 133, "header": "sp|Q5E9Z8-1|LSM1_BOVIN Isoform 1 of U6 snRNA-associated Sm-like protein LSm1 OS=Bos taurus OX=9913 GN=LSM1 PE=2 SV=1 CANONICAL=Q5E9Z8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TS05-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8/entry#A0AAA9TS05-1", "sequence": { "sequence": "MNYMPGTASLIEDIDKKHLVLLRDGRTLIGFLRSIDQFGLRKGE", "length": 44, "header": "tr|A0AAA9TS05-1|LSM1_BOVIN Computationally mapped isoform of U6 snRNA-associated Sm-like protein LSm1 OS=Bos taurus OX=9913 GN=LSM1 PE=2 SV=1 CANONICAL=Q5E9Z8-1" }, "locus": { "chromosome": "27", "start_pos": 33348551, "end_pos": 33338995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121962.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121962.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099822.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099822.1" } ] } }, { "isoform_ac": "Q5E9Z8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8/entry#Q5E9Z8-1", "sequence": { "sequence": "MNYMPGTASLIEDIDKKHLVLLRDGRTLIGFLRSIDQFANLVLHQTVERIHVGKKYGDIPRGIFVVRGENVVLLGEIDLEKESDTPLQQVSIEEILEEQRVEQQTKLEAEKLKVQALKDRGLSIPRADTLEEY", "length": 133, "header": "sp|Q5E9Z8-1|LSM1_BOVIN Isoform 1 of U6 snRNA-associated Sm-like protein LSm1 OS=Bos taurus OX=9913 GN=LSM1 PE=2 SV=1 CANONICAL=Q5E9Z8-1" }, "locus": { "chromosome": "27", "start_pos": 33348551, "end_pos": 33338844, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002113.3", "url": "https://www.ensembl.org/id/ENSBTAT00000002113.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002113.1", "url": "https://www.ensembl.org/id/ENSBTAP00000002113.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 123, "end_pos": 123, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z8", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8" } ], "site_lbl": "Ser123" }, { "start_pos": 129, "end_pos": 129, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z8", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8" } ], "site_lbl": "Thr129" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z8", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:535447", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535447", "resource": "KEGG Pathway" }, { "id": "R-BTA-430039", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-430039", "resource": "Reactome", "description": "mRNA decay by 5' to 3' exoribonuclease" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VW00-1", "protein_name": "U6 snRNA-associated Sm-like protein LSm1", "gene_name": "LSM1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNYMPGTASLIEDIDKKHLVLLRDGRTLIGFLRSIDQFANLVLHQTVERIHVGKKYGDIPRGIFVVRGENVVLLGEIDLEKESDTPLQQVSIEEILEEQRVEQQARLEAEKLKVQALKDRGLSIPRADTLDEY", "length": 133 }, "evidence": [ { "id": "Q5E9Z8", "url": "https://omabrowser.org/oma/group/Q5E9Z8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0ABK0LWE5-1", "protein_name": "U6 snRNA-associated Sm-like protein LSm1", "gene_name": "Lsm1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "GTGGPAEVSRDVRGTRARCSSSCGQASAAGHAPGTRWWRGEHARGRRGAEALREELRRRRVGTHQKSVLPRGESDVLTPGGCLPVKQDTPAPDPAEEALLSDSPAGDTSNATLESGCYQVNEKHLVLLRDGRTLIGFLRSIDQFANLVLHQTVERIHVGRKYGDIPRGIFVVRGENVVLLGEIDLEKESDTPLQQVSIEEILEEQRVEQQSRLEAEKLKVQALKDRGLSIPRADTLDEY", "length": 239 }, "evidence": [ { "id": "Q5E9Z8", "url": "https://omabrowser.org/oma/group/Q5E9Z8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H1I6-1", "protein_name": "U6 snRNA-associated Sm-like protein LSm1", "gene_name": "Lsm1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNYMPGTASLIEDIDKKHLVLLRDGRTLIGFLRSIDQFANLVLHQTVERIHVGKKYGDIPRGIFVVRGENVVLLGEIDLEKESDTPLQQVSIEEILEEQRVEQQTRLEAEKLKVQALKDRGLSIPRADTLDEY", "length": 133 }, "evidence": [ { "id": "Q5E9Z8", "url": "https://omabrowser.org/oma/group/Q5E9Z8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O15116-1", "protein_name": "U6 snRNA-associated Sm-like protein LSm1", "gene_name": "LSM1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNYMPGTASLIEDIDKKHLVLLRDGRTLIGFLRSIDQFANLVLHQTVERIHVGKKYGDIPRGIFVVRGENVVLLGEIDLEKESDTPLQQVSIEEILEEQRVEQQTKLEAEKLKVQALKDRGLSIPRADTLDEY", "length": 133 }, "evidence": [ { "id": "Q5E9Z8", "url": "https://omabrowser.org/oma/group/Q5E9Z8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54W83-1", "protein_name": "Probable U6 snRNA-associated Sm-like protein LSm1", "gene_name": "lsm1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSSGLGDEVDKKLIVVLRDGRKFIGIMRTFDQFANIVLQDTIERIYVGDCYSDKNLGLFFIRGDNVVILGEIDPDKEVQEKKLKKISWDEITKAAALEKIKKEEEEQLKRRIMTESGLTIDSILNIDDF", "length": 129 }, "evidence": [ { "id": "Q5E9Z8", "url": "https://omabrowser.org/oma/group/Q5E9Z8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8VC85-1", "protein_name": "U6 snRNA-associated Sm-like protein LSm1", "gene_name": "Lsm1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNYMPGTASLIEDIDKKHLVLLRDGRTLIGFLRSIDQFANLVLHQTVERIHVGKKYGDIPRGIFVVRGENVVLLGEIDLEKESDTPLQQVSIEEILEEQRVQQQTRLEAEKLKVQTLKDRGLSIPRADTLDEY", "length": 133 }, "evidence": [ { "id": "Q5E9Z8", "url": "https://omabrowser.org/oma/group/Q5E9Z8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9W2K2-1", "protein_name": "U6 snRNA-associated Sm-like protein LSm1", "gene_name": "LSm1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDDLNPLAGTAHLLEEVDKKLMVLLRDGRTLIGYLRSVDQFANLVLQRTIERIHVGNEYGDIPRGVFIIRGENVVLLGEIDREKEQKLPLKEISVDEILDAQRREQEQRQEKHRLVSKALKERGLAVDANIINEDFC", "length": 137 }, "evidence": [ { "id": "Q5E9Z8", "url": "https://omabrowser.org/oma/group/Q5E9Z8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "deadenylation-dependent decapping of nuclear-transcribed mRNA", "id": "GO:0000290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000290", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z8", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z8", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z8", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8" } ], "pmid": "" }, { "name": "histone mRNA catabolic process", "id": "GO:0071044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071044", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z8", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z8", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z8", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8" } ], "pmid": "" }, { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z8", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z8", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8" } ], "pmid": "" }, { "name": "Lsm1-7-Pat1 complex", "id": "GO:1990726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990726", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Z8", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9Z8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 133, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9Z8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9Z8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5E9Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z8" }, { "id": "PRU01346", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01346" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sm", "eco_id": "ECO_0000255", "start_pos": 5, "end_pos": 80, "start_aa": "Pro", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 123, 129 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q8HZJ4-1", "uniprot_ac": "Q8HZJ4", "uniprot_id": "CABP4_BOVIN", "mass": { "chemical_mass": 31164.0, "monoisotopic_mass": 31164.0 }, "refseq": { "ac": "NP_776681", "name": "calcium-binding protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776681" }, "gene_names": [ { "name": "CABP4", "type": "recommended", "evidence": [ { "id": "Q8HZJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ4" } ] }, { "name": "CABP4", "type": "synonym", "evidence": [ { "id": "NP_776681", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776681" } ] } ], "protein_names": [ { "name": "Calcium-binding protein 4", "type": "recommended", "evidence": [ { "id": "Q8HZJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ4/entry#names_and_taxonomy" } ] }, { "name": "CaBP4", "type": "synonym", "evidence": [ { "id": "Q8HZJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ4/entry#names_and_taxonomy" } ] }, { "name": "calcium-binding protein 4", "type": "synonym", "evidence": [ { "id": "NP_776681", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776681" } ] } ], "function": [ { "annotation": "May play a role in normal synaptic function, probably through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1F, shifting the activation range to more hyperpolarized voltages (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q8HZJ4", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q8HZJ4", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CABP4", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ4", "locus": { "chromosome": "29", "start_pos": 45346973, "end_pos": 45343481, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004785", "url": "https://www.ensembl.org/id/ENSBTAG00000004785" } ] } } ], "crossref": [ { "id": "Q8HZJ4", "url": "https://alphafold.ebi.ac.uk/entry/Q8HZJ4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004785", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004785", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "281656", "url": "https://www.ncbi.nlm.nih.gov/gene/281656", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043582", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043582", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281656", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281656", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EQTPIQG", "url": "https://omabrowser.org/oma/group/EQTPIQG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q8HZJ4", "url": "https://www.orthodb.org/?gene=Q8HZJ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45917", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45917", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45917:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45917:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_776681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776681", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TTM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTM1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8HZJ4", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8HZJ4-1", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEEQGRGRHGPDPAPRPQKPPVEVLASSSGAEGPPLMRKRSSKREKGLRGSRKGPSSSGEQTPMQGPEAPGSSKNPSRTREGQEGPIPSASGLAPRRQSHRHRPGPQHDAAQRMYGPLLNRIFGKDRELGPEELDELQAAFEEFDTDHDGYIGYRDLGECMRTLGYMPTEMELIEVSQHVKMRMGGRVDFEEFVEMMGPKLREETAHMLGLRELRIAFREFDRDRDGRITVAELREAAPALLGEPLVGPELEEMLQEVDLNGDGTVDFNEFVMMLSRH", "length": 279, "header": "sp|Q8HZJ4-1|CABP4_BOVIN Isoform 1 of Calcium-binding protein 4 OS=Bos taurus OX=9913 GN=CABP4 PE=2 SV=1 CANONICAL=Q8HZJ4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TTM1-1", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ4/entry#A0AAA9TTM1-1", "sequence": { "sequence": "MAEPRLAPGTCWSMPLQDRELGPEELDELQAAFEEFDTDHDGYIGYRDLGECMRTLGYMPTEMELIEVSQHVKMRMGGRVDFEEFVEMMGPKLREETAHMLGLRELRIAFREFDRDRDGRITVAELREAAPALLGEPLVGPELEEMLQEVDLNGDGTVDFNEFVMMLSRH", "length": 170, "header": "tr|A0AAA9TTM1-1|CABP4_BOVIN Computationally mapped isoform of Calcium-binding protein 4 OS=Bos taurus OX=9913 GN=CABP4 PE=2 SV=2 CANONICAL=Q8HZJ4-1" }, "locus": { "chromosome": "29", "start_pos": 45346640, "end_pos": 45344241, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134481.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134481.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100422.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100422.1" } ] } }, { "isoform_ac": "Q8HZJ4-1", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ4/entry#Q8HZJ4-1", "sequence": { "sequence": "MAEEQGRGRHGPDPAPRPQKPPVEVLASSSGAEGPPLMRKRSSKREKGLRGSRKGPSSSGEQTPMQGPEAPGSSKNPSRTREGQEGPIPSASGLAPRRQSHRHRPGPQHDAAQRMYGPLLNRIFGKDRELGPEELDELQAAFEEFDTDHDGYIGYRDLGECMRTLGYMPTEMELIEVSQHVKMRMGGRVDFEEFVEMMGPKLREETAHMLGLRELRIAFREFDRDRDGRITVAELREAAPALLGEPLVGPELEEMLQEVDLNGDGTVDFNEFVMMLSRH", "length": 279, "header": "sp|Q8HZJ4-1|CABP4_BOVIN Isoform 1 of Calcium-binding protein 4 OS=Bos taurus OX=9913 GN=CABP4 PE=2 SV=1 CANONICAL=Q8HZJ4-1" }, "locus": { "chromosome": "29", "start_pos": 45346640, "end_pos": 45343532, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006283.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006283.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006283.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006283.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 42, "end_pos": 42, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8HZJ4", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ4" } ], "site_lbl": "Ser42" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function.", "journal": "Nat. Neurosci.", "date": "2004", "authors": "Haeseleer F, Imanishi Y, Maeda T, Possin DE, Maeda A, Lee A, Rieke F, Palczewski K", "evidence": [ { "database": "UniProtKB", "id": "Q8HZJ4", "url": "https://www.uniprot.org/uniprotkb/Q8HZJ4" } ], "reference": [ { "type": "PubMed", "id": "15452577", "url": "https://glygen.org/publication/PubMed/15452577" } ] } ], "pathway": [ { "id": "bta:281656", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281656", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QL39-1", "protein_name": "Calcium-binding protein 4", "gene_name": "CABP4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATEQRGEQHGAPQQPPGGVEASGRGAEGLPLTRRRSSKKKGLRGSRKDSGSSGEQPPPQGPEAPESSKNPSRTREGQEGPGPVAPALASRRQSHRHRPASQHDAAQRTYGPLLNRIFGKDRELGPEELDELRAAFEEFDTDHDGHIGYRELGECMRTLGYMPTEMELIEVSQHVKMRMGGRVDFEEFVEMMGPKLREETAHMLGVRELRIAFREFDRDRDGRITVAELRQAAPALLGEPLAGSELDEMLREVDLNGDGTVDFDGEFPILPATPPHSSGSQAEPSASGAAGGGVSLTWTCPSPAPSLPQSL", "length": 311 }, "evidence": [ { "id": "Q8HZJ4", "url": "https://omabrowser.org/oma/group/Q8HZJ4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Z718-1", "protein_name": "Calcium binding protein 4", "gene_name": "CABP4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPRSRGDKGAPKNTEASGKGKRGEVGESAPKAPEAGGPPGSPDAESRHGGHGRKNSKKGAGDPHAASTKAYSPFLNTVFGKERELSPEELDELLDAFKEFDTDQDGFISYKDLGACMRTLGYMPTEMELIEISQHIKMRMGGRVDFEDFVQMMGPKLREETAHMVGVRELKIAFREFDVNGDGEISSAEMRQAIAALLGEQLKAQEVDEILQDVDLNGDGRVDFDEFVMMLSSR", "length": 234 }, "evidence": [ { "id": "Q8HZJ4", "url": 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"n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBL5-1", "uniprot_ac": "Q3ZBL5", "uniprot_id": "PTH2_BOVIN", "mass": { "chemical_mass": 19291.0, "monoisotopic_mass": 19291.0 }, "refseq": { "ac": "NP_001029691", "name": "peptidyl-tRNA hydrolase 2, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029691" }, "gene_names": [ { "name": "PTRH2", "type": "recommended", "evidence": [ { "id": "Q3ZBL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5" } ] }, { "name": "BIT1", "type": "synonym", "evidence": [ { "id": "NP_001029691", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029691" }, { "id": "Q3ZBL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5" } ] }, { "name": "PTRH2", "type": "synonym", "evidence": [ { "id": "NP_001029691", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029691" } ] } ], "protein_names": [ { "name": "Peptidyl-tRNA hydrolase 2, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q3ZBL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5/entry#names_and_taxonomy" } ] }, { "name": "3.1.1.29", "type": "synonym", "evidence": [ { "id": "Q3ZBL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5/entry#names_and_taxonomy" } ] }, { "name": "Bcl-2 inhibitor of transcription", "type": "synonym", "evidence": [ { "id": "NP_001029691", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029691" }, { "id": "Q3ZBL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5/entry#names_and_taxonomy" } ] }, { "name": "PTH 2", "type": "synonym", "evidence": [ { "id": "NP_001029691", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029691" }, { "id": "Q3ZBL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5/entry#names_and_taxonomy" } ] }, { "name": "peptidyl-tRNA hydrolase 2, mitochondrial precursor", "type": "synonym", "evidence": [ { "id": "NP_001029691", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029691" } ] }, { "name": "peptidyl-tRNA hydrolase 2, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001029691", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029691" } ] } ], "function": [ { "annotation": "Peptidyl-tRNA hydrolase which releases tRNAs from the ribosome during protein synthesis. Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5#function" }, { "database": "UniProtKB", "id": "Q9Y3E5", "url": "https://www.uniprot.org/uniprotkb/Q9Y3E5#function" }, { "database": "UniProtKB", "id": "A0AAA9TY37", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY37#function" }, { "database": "UniProtKB", "id": "ARBA00059027", "url": "https://www.uniprot.org/uniprotkb/ARBA00059027#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTRH2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5", "locus": { "chromosome": "19", "start_pos": 10654194, "end_pos": 10674481, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000055796", "url": "https://www.ensembl.org/id/ENSBTAG00000055796" } ] } } ], "crossref": [ { "id": "Q3ZBL5", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBL5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016710", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016710", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02430", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02430", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "516595", "url": "https://www.ncbi.nlm.nih.gov/gene/516595", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002833", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002833", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023476", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023476", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516595", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516595", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GHAAVEC", "url": "https://omabrowser.org/oma/group/GHAAVEC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBL5", "url": "https://www.orthodb.org/?gene=Q3ZBL5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12649", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12649", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12649:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12649:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01981", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01981", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689880", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029691", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "54448", "url": "https://www.rhea-db.org/rhea/54448", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TY37", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY37", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY37-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY37-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBL5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MISRSLVMEYLTNPGALSLAAGVACGVCLGWGLRMRFGMLPKSSVRETNPDTETEASILGESGEYKMILVVRNDLKMGKGKVAAQCSHAAVSAYKQIQRRNPELLKEWEYCGQPKVVVKAPDEETLVELLTHAKVLGLTVSLIQDAGRTQIAPGSRTVLGIGPGPADLIDKVTGHLKLY", "length": 179, "header": "sp|Q3ZBL5-1|PTH2_BOVIN Isoform 1 of Peptidyl-tRNA hydrolase 2, mitochondrial OS=Bos taurus OX=9913 GN=PTRH2 PE=2 SV=1 CANONICAL=Q3ZBL5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TY37-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5/entry#A0AAA9TY37-1", "sequence": { "sequence": "MTAFFSFQMISRSLVMEYLTNPGALSLAAGVACGVCLGWGLRMRFGMLPKSSVRETNPDTETEASILGESGEYKMILVVRNDLKMGKGKVAAQCSHAAVSAYKQIQRRNPELLKEWEYCGQPKVVVKAPDEETLVELLTHAKVLGLTVSLIQDAGRTQIAPGSRTVLGIGPGPADLIDKVTGHLKLY", "length": 187, "header": "tr|A0AAA9TY37-1|PTH2_BOVIN Computationally mapped isoform of Peptidyl-tRNA hydrolase 2, mitochondrial OS=Bos taurus OX=9913 GN=PTRH2 PE=2 SV=1 CANONICAL=Q3ZBL5-1" }, "locus": { "chromosome": "19", "start_pos": 10665922, "end_pos": 10665362, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109156.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109156.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102106.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102106.1" } ] } }, { "isoform_ac": "Q3ZBL5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5/entry#Q3ZBL5-1", "sequence": { "sequence": "MISRSLVMEYLTNPGALSLAAGVACGVCLGWGLRMRFGMLPKSSVRETNPDTETEASILGESGEYKMILVVRNDLKMGKGKVAAQCSHAAVSAYKQIQRRNPELLKEWEYCGQPKVVVKAPDEETLVELLTHAKVLGLTVSLIQDAGRTQIAPGSRTVLGIGPGPADLIDKVTGHLKLY", "length": 179, "header": "sp|Q3ZBL5-1|PTH2_BOVIN Isoform 1 of Peptidyl-tRNA hydrolase 2, mitochondrial OS=Bos taurus OX=9913 GN=PTRH2 PE=2 SV=1 CANONICAL=Q3ZBL5-1" }, "locus": { "chromosome": "19", "start_pos": 10665898, "end_pos": 10665362, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135417.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135417.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083810.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083810.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:516595", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516595", "resource": "KEGG Pathway" }, { "id": "R-BTA-5689880", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689880", "resource": "Reactome", "description": "Ub-specific processing proteases" } ], "orthologs": [ { "uniprot_canonical_ac": "E1BWS4-1", "protein_name": "Peptidyl-tRNA hydrolase 2, mitochondrial", "gene_name": "PTRH2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDYLSKPGFLSILAGVACGVCLGWGIRGRFLRQHRAMAASAGSCGTEANVMGESGEFKMVLIVRNDLKMGKGKVAAQCSHAAVSAYKQIQRRNPELLKQWEYCGQPKVVLKAPDEETLIQLLIDAKRLGLTVSLVQDAGRTQIAPGSQTVLGIGPGPADVIDKVSGHLKLF", "length": 171 }, "evidence": [ { "id": "Q3ZBL5", "url": "https://omabrowser.org/oma/group/Q3ZBL5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S227-1", "protein_name": "Peptidyl-tRNA hydrolase 2, mitochondrial", "gene_name": "PTRH2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MISMPLVMEYLANPGALSFAAGVACGMCLGWGLRVRFGMIPKSSVSETDTDTETEASILGESGEYKMILVVRNDLKMGKGKVAAQCSHAAVSAYKQIQRRNPELLQQWEYCGQPKVVVKAPDEETLVELLTHAKMLGLTVSLIQDAGRTQIAPGSRTVLGIGPGPVDLIDKVTGHLKLY", "length": 179 }, "evidence": [ { "id": "Q3ZBL5", "url": "https://omabrowser.org/oma/group/Q3ZBL5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O97067-1", "protein_name": "Probable peptidyl-tRNA hydrolase 2", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGDKLLDPTQIINGLAVMLSFFVGYRYALKRGDAKDSVTEGAATPFSQESSVSSGSEASVSDKGYGGLNDNFKMVLVVRNDLKMGKGKIAAQCGHGAVGAYQRAVVRTPRLLRSWENCGCAKIAVRVESEAELMAIKKEAERQQLNTCLIRDAGRTQIEANSKTVLAVGPAAAADIDRVTGHLKLL", "length": 186 }, "evidence": [ { "id": "Q3ZBL5", "url": "https://omabrowser.org/oma/group/Q3ZBL5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q8R2Y8-1", "protein_name": "Peptidyl-tRNA hydrolase 2, mitochondrial", "gene_name": "Ptrh2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSKFLTMEYLVHPGTLSLAAGVACGMCLGWGLRSHLGMFPQNSTSEANRDTETGTEASILGESGEYKMILVVRTDLKMGKGKVAAQCSHAAVSAYKQTQRRSPQVLKEWEYCGQPKVVVKAPDEDTLIQLLTHAKTLGLTVSLIQDAGRTQIEPGSRTVLGIGPGPVELIDEVTGHLKLY", "length": 181 }, "evidence": [ { "id": "Q3ZBL5", "url": "https://omabrowser.org/oma/group/Q3ZBL5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y3E5-1", "protein_name": "Peptidyl-tRNA hydrolase 2, mitochondrial", "gene_name": "PTRH2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPSKSLVMEYLAHPSTLGLAVGVACGMCLGWSLRVCFGMLPKSKTSKTHTDTESEASILGDSGEYKMILVVRNDLKMGKGKVAAQCSHAAVSAYKQIQRRNPEMLKQWEYCGQPKVVVKAPDEETLIALLAHAKMLGLTVSLIQDAGRTQIAPGSQTVLGIGPGPADLIDKVTGHLKLY", "length": 179 }, "evidence": [ { "id": "Q3ZBL5", "url": "https://omabrowser.org/oma/group/Q3ZBL5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "peptidyl-tRNA hydrolase activity", "id": "GO:0004045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004045", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of anoikis", "id": "GO:2000210", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000210", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5" } ], "pmid": "" }, { "name": "negative regulation of anoikis", "id": "GO:2000811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000811", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBL5", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "54448", "name": "", "equation": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3SZ85-1", "Q3ZBL5-1", "Q3T116-1", "A0AAA9SGN5-1" ], "evidence": [ { "id": "54448", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/54448" } ] }, { "id": "R-BTA-5696872", "name": "USP30 deubiquitinates Ub-MOM proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, mitochondrial outer membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2HJF8-1", "Q24K02-1", "F1MSB6-1", "E1BGD5-1", "A0A3Q1LK42-1", "Q3ZBL5-1" ], "evidence": [ { "id": "R-BTA-5696872", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696872" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LK42", "gene_name": "FKBP8", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A3Q1LK42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LK42" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A3Q1LK42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LK42" } ] } ] }, { "uniprot_ac": "A0AAA9SGN5", "gene_name": "PTRH1", "activity": [ { "ec_number": "3.1.1.29", "activity": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+).", "evidence": [ { "id": "A0AAA9SGN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN5" } ] }, { "ec_number": "3.1.1.29", "activity": "", "evidence": [ { "id": "A0AAA9SGN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN5" } ] } ] }, { "uniprot_ac": "E1BGD5", "gene_name": "MUL1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BGD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGD5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BGD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGD5" } ] } ] }, { "uniprot_ac": "F1MSB6", "gene_name": "USP30", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "F1MSB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSB6" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "F1MSB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSB6" } ] } ] }, { "uniprot_ac": "Q24K02", "gene_name": "IDE", "activity": [ { "ec_number": "3.4.24.56", "activity": "Degradation of insulin, glucagon and other polypeptides. No action on proteins.", "evidence": [ { "id": "Q24K02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K02" } ] }, { "ec_number": "3.4.24.56", "activity": "", "evidence": [ { "id": "Q24K02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K02" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q3SZ85", "gene_name": "PTRHD1", "activity": [ { "ec_number": "3.1.1.29", "activity": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+).", "evidence": [ { "id": "Q3SZ85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ85" } ] }, { "ec_number": "3.1.1.29", "activity": "", "evidence": [ { "id": "Q3SZ85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ85" } ] } ] }, { "uniprot_ac": "Q3T116", "gene_name": "MRPL58", "activity": [ { "ec_number": "3.1.1.29", "activity": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+).", "evidence": [ { "id": "Q3T116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T116" } ] }, { "ec_number": "3.1.1.29", "activity": "", "evidence": [ { "id": "Q3T116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T116" } ] } ] }, { "uniprot_ac": "Q3ZBL5", "gene_name": "PTRH2", "activity": [ { "ec_number": "3.1.1.29", "activity": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+).", "evidence": [ { "id": "Q3ZBL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5" } ] }, { "ec_number": "3.1.1.29", "activity": "", "evidence": [ { "id": "Q3ZBL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBL5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 179, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBL5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBL5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.1.29", "ec_name": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+).", "evidence": [ { "id": "3.1.1.29", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29" }, { "id": "3.1.1.29", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.29" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q95J56-1", "uniprot_ac": "Q95J56", "uniprot_id": "DJC14_BOVIN", "mass": { "chemical_mass": 78178.0, "monoisotopic_mass": 78178.0 }, "refseq": { "ac": "NP_776699", "name": "dnaJ homolog subfamily C member 14", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776699" }, "gene_names": [ { "name": "DNAJC14", "type": "recommended", "evidence": [ { "id": "Q95J56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95J56" } ] }, { "name": "DNAJ1", "type": "synonym", "evidence": [ { "id": "NP_776699", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776699" } ] }, { "name": "DNAJC14", "type": "synonym", "evidence": [ { "id": "NP_776699", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776699" } ] }, { "name": "jiv", "type": "synonym", "evidence": [ { "id": "NP_776699", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776699" } ] } ], "protein_names": [ { "name": "DnaJ homolog subfamily C member 14", "type": "recommended", "evidence": [ { "id": "Q95J56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95J56/entry#names_and_taxonomy" } ] }, { "name": "DnaJ (Hsp40) homolog, subfamily C, member 14", "type": "synonym", "evidence": [ { "id": "NP_776699", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776699" } ] }, { "name": "J domain protein interacting with viral protein", "type": "synonym", "evidence": [ { "id": "Q95J56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95J56/entry#names_and_taxonomy" } ] }, { "name": "J-domain protein Jiv", "type": "synonym", "evidence": [ { "id": "NP_776699", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776699" } ] }, { "name": "Jiv", "type": "synonym", "evidence": [ { "id": "Q95J56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95J56/entry#names_and_taxonomy" } ] }, { "name": "contains putative zinc finger domain", "type": "synonym", "evidence": [ { "id": "NP_776699", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776699" } ] }, { "name": "dnaJ homolog subfamily C member 14", "type": "synonym", "evidence": [ { "id": "NP_776699", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776699" } ] }, { "name": "dopamine receptor interacting protein", "type": "synonym", "evidence": [ { "id": "NP_776699", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776699" } ] }, { "name": "j domain protein interacting with viral protein", "type": "synonym", "evidence": [ { "id": "NP_776699", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776699" } ] } ], "function": [ { "annotation": "Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity). Promotes cleavage of pestivirus polyprotein.", "evidence": [ { "database": "UniProtKB", "id": "Q95J56", "url": "https://www.uniprot.org/uniprotkb/Q95J56#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q95J56", "url": "https://www.uniprot.org/uniprotkb/Q95J56" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAJC14", "url": "https://www.uniprot.org/uniprotkb/Q95J56", "locus": { "chromosome": "5", "start_pos": 57449491, "end_pos": 57439666, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020664", "url": "https://www.ensembl.org/id/ENSBTAG00000020664" } ] } } ], "crossref": [ { "id": "Q95J56", "url": "https://alphafold.ebi.ac.uk/entry/Q95J56", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020664", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020664", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "281691", "url": "https://www.ncbi.nlm.nih.gov/gene/281691", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q95J56", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q95J56*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032843", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032843", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281691", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281691", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WLELPWF", "url": "https://omabrowser.org/oma/group/WLELPWF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q95J56", "url": "https://www.orthodb.org/?gene=Q95J56", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44665", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44665", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44665:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44665:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14901", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14901", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_776699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776699", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9U128", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U128", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U128-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U128-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q95J56", "url": "https://www.uniprot.org/uniprotkb/Q95J56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q95J56-1", "url": "https://www.uniprot.org/uniprotkb/Q95J56-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQKHPGEGGLCGAHHSGGASLRTLGPSVDPDILSFSGLRDSAGSAPNGTRCLTEHSSPKYTQPPNPAHWSDPSHGPPRGPGPPLAEEDPDQSEASSEESGVDQELSRENETGYQDDGNSSFLSIPSTCNCQGTPGIPEGPYSEGRDSSSSNFCHHCTSPALGEDEELEGEYDEEEPLKFPSDVSRVPSEKKPAPRRQRHRVPAKEDTREGGRRDPRSPGRHRLGRKRSQADKRRGLGLWGAEELCQLGQAGFWWLIELLVLVGEYVETCGHLIYACRQLKGSDLDLLRVWVGVWAGRLRGWAQVMFQFLSQGFCYGAGLFTRFLRLVGALLLLALALLLGCLQLGWRFLVGLSDRLGWRDKATWIFSWLASPTWQRCLILLRESRPWQQLVRIVQWGWLELPWVKQRTNRQANAPVAGGRYCQPEEEVARLLTMAGVPEDELNPFHVLGVEATASDVELKKAYRQLAVMVHPDKNHHPRAEEAFKVLRAAWDIVSNPERRKEYEMKRMAENELSRSVNEFLSKLQEAMNTMMCSRCQGKHRRFEMDREPKSARYCAECNRLHPAEEGDFWAESSMLGLKITYFALMDGKVYDITEWAGCQRVGISPDTHRVPYHISFGSRMPGTSGRQRATPDAPPADLQDFLSRIFQVPPGQMSNGNFFAAPQPGPGATAASKPNSTVPKGEAKPKRRKKVRRPFQR", "length": 699, "header": "sp|Q95J56-1|DJC14_BOVIN Isoform 1 of DnaJ homolog subfamily C member 14 OS=Bos taurus OX=9913 GN=DNAJC14 PE=1 SV=1 CANONICAL=Q95J56-1" }, "isoforms": [ { "isoform_ac": "A0AAA9U128-1", "url": "https://www.uniprot.org/uniprotkb/Q95J56/entry#A0AAA9U128-1", "sequence": { "sequence": "MAQKHPGEGGLCGAHHSGGASLRTLGPSVDPDILSFSGLRDSAGSAPNGTRCLTEHSSPKYTQPPNPAHWSDPSHGPPRGPGPPLAEEDPDQSEASSEESGVDQELSRENETGYQDDGNSSFLSIPSTCNCQGTPGIPEGPYSEGRDSSSSNFCHHCTSPALGEDEELEGEYDEEEPLKFPSDVSRVPSEKKPAPRRQRHRVPAKEDTREGGRRDPRSPGRHRLGRKRSQADKRRGLGLWGAEELCQLGQAGFWWLIELLVLVGEYVETCGHLIYACRQLKGSDLDLLRVWVGVWAGRLRGWAQVMFQFLSQGFCYGAGLFTRFLRLVGALLLLALALLLGCLQLGWRFLVGLSDRLGWRDKATWIFSWLASPTWQRCLILLRESRPWQQLVRIVQWGWLELPWVKQRTNRQANAPVAGGRYCQPEEEVARLLTMAGVPEDELNPFHVLGVEATASDVELKKAYRQLAVMVHPDKNHHPRAEEAFKVLRAAWDIVSNPERRKEYEMKRMAENELSRSVNEFLSKLQEAMNTMMCSRCQGKHRRFEMDREPKSARYCAECNRLHPAEEGDFWAESSMLGLKITYFALMDGKVYDITEWAGCQRVGISPDTHRVPYHISFGSRMPGTSGRQRATPDAPPADLQDFLSRIFQVPPGQMSNGNFFAAPQPGPGATAASKPNSTVPKGEAKPKRRKKGCLQRSSSGLLLAAASLTPLVRLPPFF", "length": 719, "header": "tr|A0AAA9U128-1|DJC14_BOVIN Computationally mapped isoform of DnaJ homolog subfamily C member 14 OS=Bos taurus OX=9913 GN=DNAJC14 PE=1 SV=1 CANONICAL=Q95J56-1" }, "locus": { "chromosome": "5", "start_pos": 57449009, "end_pos": 57439722, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100823.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100823.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102860.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102860.1" } ] } }, { "isoform_ac": "Q95J56-1", "url": "https://www.uniprot.org/uniprotkb/Q95J56/entry#Q95J56-1", "sequence": { "sequence": "MAQKHPGEGGLCGAHHSGGASLRTLGPSVDPDILSFSGLRDSAGSAPNGTRCLTEHSSPKYTQPPNPAHWSDPSHGPPRGPGPPLAEEDPDQSEASSEESGVDQELSRENETGYQDDGNSSFLSIPSTCNCQGTPGIPEGPYSEGRDSSSSNFCHHCTSPALGEDEELEGEYDEEEPLKFPSDVSRVPSEKKPAPRRQRHRVPAKEDTREGGRRDPRSPGRHRLGRKRSQADKRRGLGLWGAEELCQLGQAGFWWLIELLVLVGEYVETCGHLIYACRQLKGSDLDLLRVWVGVWAGRLRGWAQVMFQFLSQGFCYGAGLFTRFLRLVGALLLLALALLLGCLQLGWRFLVGLSDRLGWRDKATWIFSWLASPTWQRCLILLRESRPWQQLVRIVQWGWLELPWVKQRTNRQANAPVAGGRYCQPEEEVARLLTMAGVPEDELNPFHVLGVEATASDVELKKAYRQLAVMVHPDKNHHPRAEEAFKVLRAAWDIVSNPERRKEYEMKRMAENELSRSVNEFLSKLQEAMNTMMCSRCQGKHRRFEMDREPKSARYCAECNRLHPAEEGDFWAESSMLGLKITYFALMDGKVYDITEWAGCQRVGISPDTHRVPYHISFGSRMPGTSGRQRATPDAPPADLQDFLSRIFQVPPGQMSNGNFFAAPQPGPGATAASKPNSTVPKGEAKPKRRKKVRRPFQR", "length": 699, "header": "sp|Q95J56-1|DJC14_BOVIN Isoform 1 of DnaJ homolog subfamily C member 14 OS=Bos taurus OX=9913 GN=DNAJC14 PE=1 SV=1 CANONICAL=Q95J56-1" }, "locus": { "chromosome": "5", "start_pos": 57445179, "end_pos": 57439722, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027541.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027541.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027541.3", "url": "https://www.ensembl.org/id/ENSBTAP00000027541.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "A cellular J-domain protein modulates polyprotein processing and cytopathogenicity of a pestivirus.", "journal": "J. Virol.", "date": "2001", "authors": "Rinck G, Birghan C, Harada T, Meyers G, Thiel HJ, Tautz N", "evidence": [ { "database": "UniProtKB", "id": "Q95J56", "url": "https://www.uniprot.org/uniprotkb/Q95J56" } ], "reference": [ { "type": "PubMed", "id": "11533209", "url": "https://glygen.org/publication/PubMed/11533209" } ] }, { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q95J56", "url": "https://www.uniprot.org/uniprotkb/Q95J56" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:281691", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281691", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SPJ3-1", "protein_name": "DnaJ homolog subfamily C member 14", "gene_name": "DNAJC14", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAQKHPGERGLCGAHHSGGASLRTLGPSVDPEILSFSGLRDSAGPAPNGARCLTEHSSPKYTQPPNPAHWSDPSHGPPRGPGPPRNGEDPDQSEASSEEESGVDQELSKENEAGYQEDGNPSFLSIPSACDCQGIPGIPEGPYSQGGDSSSSNFCHHCTTPALGEDEELEEEYDDEEPLKFPNDFSRVPSGKKPPPRRQRHRIPAKEDTREGGRRDPRPGRHRLGRKRSQADKRRGLGLWGAEELCQLGQAGFWWLIELLVLVGEYVETCGHLIYACRQLKGSDLDLFRVWVGVWAGRLGTWAQLMFQFLSQGFSCGAGLFIRFLRLLGALLLWVLALLLGCLQLGWWFLVGLGDRLGWRGKAAWLFSWLASPTWQRCLILLKDSRPWQQLVRMVQRGWLELPWVKQRTDRQGNAPVASGRYCQPEEEVARLLTMAGVPEDELNPFHVLGVEATASDVELKKAYRQLAVMVHPDKNRHPRAEEAFKVLRAAWDIVSNPERRKEYEMKRMAENELSRSVNEFLSKLQDDLKEAMNTMMCSRCQGKHRRFEMDREPKNARYCAECKRLHPAEEGDFWAESSMFGLKITYFALMDGKVYDITEWAGCQRVGISPDTHRVPYHISFGSRMPGTSGRQRATPDAPPADLQDFLSRIFQVPPGQMSNGNFFAGPQPGSGATAASKPNSTVPKGEAKPKRRKKVRRPFQR", "length": 703 }, "evidence": [ { "id": "Q95J56", "url": "https://omabrowser.org/oma/group/Q95J56/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HRL2-1", "protein_name": "DnaJ homolog subfamily C member 14", "gene_name": "Dnajc14", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAQKHPGEGGLCGAHHTGGASLRTSGPSVDPEILSFSGLRDSTETAPNGTRCLTEPSGSKYTQPPNPAHWSDPSHGPPRGPGPPREGGYLDESETSSEGSGADQELSRENETGYQEDGSPSFLSIPSACNCQGSPGIPEGTYSEEGDGSSSNFCHHCTSPALGEDEELEEEYDDEEPLKFPSDFSRVSSGKKPPSRRQRHRFLTKEDTRDSGRRDPRSPGRHRLGRKRNQTDKRRGLGLWGVEELCQLGQAGFWWLIELLVLVGEYVETCGHLIYACRQLKGSDLNLFRVWVGSWAGRLGGWAQVMVQCLSQSFSCAAGLFTRLLRLVGAFLLLALALLLGCLQLGWRFLVGLGDRLGWRDRTTRLFSWLASPAVHRCLTLLRDSRPWQQLVRLVQRNWLEFPWVKPRTNKQGNAPAASGRHCQPEEEVARLLTMAGVPEDELNPFHVLGVEATASDMELKKAYRQLAVMVHPDKNHHPRAEEAFKVLRAAWDIVSNPERRKEYEMKRMAENELSRSVNEFLSKLQDDLKEAMNTMMCSRCQGKHRRFEMDREPKSARYCAECNRLHPAEEGDFWAESSMLGLKITYFALMDGKVYDITEWAGCQRVGISPDTHRVPYHISFGSRVPGTSGRQRATPETPPADLQDFLSRIFQVPPGQMSNGNFFAAPHPGPGATATSKPNSTVPKGEAKPKRRKKVRRPFQR", "length": 703 }, "evidence": [ { "id": "Q95J56", "url": "https://omabrowser.org/oma/group/Q95J56/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5XIX0-1", "protein_name": "DnaJ homolog subfamily C member 14", "gene_name": "Dnajc14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQKHPGERGLCGVHHSGGSSLITSGSSVDPEILSFSGLRDSKETAPNGTRCLKEHSDPKCTQPPNPAHWSDPSHGPPRGPGPPREGGYPDESETCSEESGVDQELSRENETGYQEDGSPSFLPIPSACNCQGSPGVPEGTCSEEGDGSSSSFCHHCTSPALGEDEELEEEYDDEEPLKFPSDFSRVSSGKKPPSRRQRHRFLTKEDVRDSGRRDPKAPGRHRLARKRSQTDKRRGLGLWGVEELCQLGQAGFWWLIELLVLVGEYVETCGYLIYACRKLKGSDLDLFRIWVGVWARRLGGWARVMFQFLSQSFFSVAGLFIRLLRVVGAFLLLALALFLGCLQLGWRFLVGLGDRLGWRGKAAWLFSWLDSPALHHFLTLLKDSRPWQQLVRVIQWGWLELPWVKQRTQRQGTAHVASGRYCQPEEEVARLLTMAGVPEDELNPFHVLGVEATASDIELKKAYRQLAVMVHPDKNHHPRAEEAFKVLRAAWDIVSNPERRKEYEMKRMAENELSRSVNEFLSKLQDDLKEAMNTMMCSRCQGKHRRFEMDREPKSARYCAECNRLHPAEEGDFWAESSMLGLKITYFALMDGKVYDITEWAGCQRVGISPDTHRVPYHISFGSRVPGTSGRQRATPESPPADLQDFLSRIFQVPPGPMSNGNFFAAPHPGPGTTSTSRPNSSVPKGEAKPKRRKKVRRPFQR", "length": 703 }, "evidence": [ { "id": "Q95J56", "url": "https://omabrowser.org/oma/group/Q95J56/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6Y2X3-1", "protein_name": "DnaJ homolog subfamily C member 14", "gene_name": "DNAJC14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQKHPGERGLYGAHHSGGASLRTLGPSVDPEIPSFSGLRDSAGTAPNGTRCLTEHSGPKHTQHPNPAHWLDPSHGPPGGPGPPRDAEDPDQSETSSEEESGVDQELSKENETGNQKDGNSFLSIPSACNCQGTPGIPEGPYSEGGNGSSSNFCHHCTSPALGEDELEEEYDDEESLKFPSDFSRVSSGKKPPSRRQRHRFPTKEDTREGGRRDPRSPGRHRLGRKRSQADKRKGLGLWGAEELCQLGQAGFWWLIELLVLVGEYVETCGHLIYACRQLKSSDLDLFRVWMGVWTGRLGGWAQVMFQFLSQGFYCGVGLFTRFLKLLGALLLLALALFLGFLQLGWRFLVGLGDRLGWRDKATWLFSWLDSPALQRCLTLLRDSRPWQRLVRIVQWGWLELPWVKQNINRQGNAPVASGRYCQPEEEVARLLTMAGVPEDELNPFHVLGVEATASDVELKKAYRQLAVMVHPDKNHHPRAEEAFKVLRAAWDIVSNAEKRKEYEMKRMAENELSRSVNEFLSKLQDDLKEAMNTMMCSRCQGKHRRFEMDREPKSARYCAECNRLHPAEEGDFWAESSMLGLKITYFALMDGKVYDITEWAGCQRVGISPDTHRVPYHISFGSRIPGTRGRQRATPDAPPADLQDFLSRIFQVPPGQMPNGNFFAAPQPAPGAAAASKPNSTVPKGEAKPKRRKKVRRPFQR", "length": 702 }, "evidence": [ { "id": "Q95J56", "url": "https://omabrowser.org/oma/group/Q95J56/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q921R4-1", "protein_name": "DnaJ homolog subfamily C member 14", "gene_name": "Dnajc14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQKHPGERRLCGAHRSGGTSLSTSGSSVDPEILSFSGLRDSAETAPNGTRCLKEHSGPKYTQPPNPAHWSDPSHGPPRGPGPPRGGGYPDESETGSEESGVDQELSRENETGYQEDGSPSFLSIPSACNCQGSPGVPEGTYSEEGDGSSSSLCHHCTSPALGEDEELEEEYDDEEPLKFPSDFSRVSSGKKPLSRRQKHRFLIKEDVRDSGRREPKAPGRHRLARKRSQTDKRRGLGLWGVEELCQLGQAGFWWLIELLVLVGEYVETCGHLIYACRKLKGSDLDLFRVWVGVWARRLGGWARMMFQFLSQSFFCVVGLLIRILRVVGAFLLLALALFLGCLQLGWRFSVGLGNRLGWRDKTAWLFSWLGSPALHHCLTLLKDSRPWQQLVRLIQWGWQELPWVKQRTKKQGNAPVASGRYCQPEEEVTRLLTMAGVPEDELNPFHVLGVEATASDTELKKAYRQLAVMVHPDKNHHPRAEEAFKILRAAWDIVSNPERRKEYEMKRMAENELSRSVNEFLSKLQDDLKEAMNTMMCSRCQGKHRRFEMDREPKSARYCAECNRLHPAEEGDFWAESSMLGLKITYFALMDGKVYDITEWAGCQRVGISPDTHRVPYHISFGSRVPGTSGRQRATPESPPADLQDFLSRIFQVPPGPMSNGNFFAAPHPGPGTTSTSRPNSSVPKGEAKPKRRKKVRRPFQR", "length": 703 }, "evidence": [ { "id": "Q95J56", "url": "https://omabrowser.org/oma/group/Q95J56/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "dopamine receptor binding", "id": "GO:0050780", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050780", "evidence": [ { "database": "UniProtKB", "id": "Q95J56", "url": "https://www.uniprot.org/uniprotkb/Q95J56" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q95J56", "url": "https://www.uniprot.org/uniprotkb/Q95J56" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q95J56", "url": "https://www.uniprot.org/uniprotkb/Q95J56" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" }, { "start_pos": 677, "end_pos": 679, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q95J56-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 699, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q95J56-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q95J56" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q95J56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95J56" }, { "id": "PRU00286", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00286" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "J", "eco_id": "ECO_0000255", "start_pos": 444, "end_pos": 508, "start_aa": "Asn", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 }, { "start_pos": 119, "end_pos": 121 }, { "start_pos": 48, "end_pos": 50 }, { "start_pos": 677, "end_pos": 679 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q8HYB6-1", "uniprot_ac": "Q8HYB6", "uniprot_id": "GBRL1_BOVIN", "mass": { "chemical_mass": 14044.0, "monoisotopic_mass": 14044.0 }, "refseq": { "ac": "NP_001028788", "name": "gamma-aminobutyric acid receptor-associated protein-like 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028788" }, "gene_names": [ { "name": "GABARAPL1", "type": "recommended", "evidence": [ { "id": "Q8HYB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HYB6" } ] }, { "name": "GABARAPL1", "type": "synonym", "evidence": [ { "id": "NP_001028788", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028788" } ] } ], "protein_names": [ { "name": "Gamma-aminobutyric acid receptor-associated protein-like 1", "type": "recommended", "evidence": [ { "id": "Q8HYB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HYB6/entry#names_and_taxonomy" } ] }, { "name": "GABA(A) receptor-associated protein like 1", "type": "synonym", "evidence": [ { "id": "NP_001028788", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028788" } ] }, { "name": "GABA(A) receptor-associated protein-like 1", "type": "synonym", "evidence": [ { "id": "Q8HYB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HYB6/entry#names_and_taxonomy" } ] }, { "name": "MDBK gamma-aminobutyric acid-receptor-associated protein", "type": "synonym", "evidence": [ { "id": "NP_001028788", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028788" } ] }, { "name": "gamma-aminobutyric acid receptor-associated protein-like 1", "type": "synonym", "evidence": [ { "id": "NP_001028788", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028788" } ] } ], "function": [ { "annotation": "Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover.", "evidence": [ { "database": "UniProtKB", "id": "Q8HYB6", "url": "https://www.uniprot.org/uniprotkb/Q8HYB6#function" }, { "database": "UniProtKB", "id": "Q9H0R8", "url": "https://www.uniprot.org/uniprotkb/Q9H0R8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q8HYB6", "url": "https://www.uniprot.org/uniprotkb/Q8HYB6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GABARAPL1", "url": "https://www.uniprot.org/uniprotkb/Q8HYB6", "locus": { "chromosome": "5", "start_pos": 99763640, "end_pos": 99773990, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011765", "url": "https://www.ensembl.org/id/ENSBTAG00000011765" } ] } } ], "crossref": [ { "id": "Q8HYB6", "url": "https://alphafold.ebi.ac.uk/entry/Q8HYB6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011765", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011765", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16127", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16127", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "338472", "url": "https://www.ncbi.nlm.nih.gov/gene/338472", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004241", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004241", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:338472", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:338472", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KNQIRAK", "url": "https://omabrowser.org/oma/group/KNQIRAK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q8HYB6", "url": "https://www.orthodb.org/?gene=Q8HYB6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10969", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10969", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02991", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02991", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1632852", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001028788", "url": 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"A0AAA9U1D3-1", "url": "https://www.uniprot.org/uniprotkb/Q8HYB6/entry#A0AAA9U1D3-1", "sequence": { "sequence": "MKFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEEDYFLYVAYSDESVYGKVMIWVGSRNLHPDGTFQFISRHFSSSP", "length": 144, "header": "tr|A0AAA9U1D3-1|GBRL1_BOVIN Computationally mapped isoform of Gamma-aminobutyric acid receptor-associated protein-like 1 OS=Bos taurus OX=9913 GN=GABARAPL1 PE=3 SV=1 CANONICAL=Q8HYB6-1" }, "locus": { "chromosome": "5", "start_pos": 99773736, "end_pos": 99764644, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128784.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128784.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103886.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103886.1" } ] } }, { "isoform_ac": "Q8HYB6-1", "url": "https://www.uniprot.org/uniprotkb/Q8HYB6/entry#Q8HYB6-1", "sequence": { "sequence": 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"start_pos": 87, "start_aa": "Thr", "end_pos": 87, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr87", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Cellular sequences in pestivirus genomes encoding gamma-aminobutyric acid (A) receptor-associated protein and Golgi-associated ATPase enhancer of 16 kilodaltons.", "journal": "J. 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"length": 117 }, "evidence": [ { "id": "Q8HYB6", "url": "https://omabrowser.org/oma/group/Q8HYB6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZZH1-1", "protein_name": "GABA type A receptor associated protein like 1", "gene_name": "GABARAPL1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "SRSGTARSCAPLCSACVRCAGVVAFAECPVVGDGGRAVAGSAVSHHEVPVQGRPPVRVQEKRRRENQEEIPRQSPLGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEEDYFLYVAYSDESVYGK", "length": 136 }, "evidence": [ { "id": "Q8HYB6", "url": "https://omabrowser.org/oma/group/Q8HYB6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3I1V1-1", "protein_name": "Gamma-aminobutyric acid receptor-associated protein-like 1 isoform X1", "gene_name": "Gabarapl1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEEDYFLYVAYSDESVYGK", "length": 117 }, "evidence": [ { "id": "Q8HYB6", "url": "https://omabrowser.org/oma/group/Q8HYB6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8R3R8-1", "protein_name": "Gamma-aminobutyric acid receptor-associated protein-like 1", "gene_name": "Gabarapl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEEDYFLYVAYSDESVYGK", "length": 117 }, "evidence": [ { "id": "Q8HYB6", "url": "https://omabrowser.org/oma/group/Q8HYB6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H0R8-1", "protein_name": "Gamma-aminobutyric acid receptor-associated protein-like 1", "gene_name": "GABARAPL1", "tax_id": 9606, "organism": "Homo sapiens", 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"type": "synonym", "evidence": [ { "id": "NP_001019658", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019658" } ] }, { "name": "protease inhibitor 16", "type": "synonym", "evidence": [ { "id": "NP_001019658", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019658" } ] } ], "function": [ { "annotation": "May inhibit cardiomyocyte growth.", "evidence": [ { "database": "UniProtKB", "id": "Q58D34", "url": "https://www.uniprot.org/uniprotkb/Q58D34#function" }, { "database": "UniProtKB", "id": "Q9ET66", "url": "https://www.uniprot.org/uniprotkb/Q9ET66#function" }, { "database": "UniProtKB", "id": "A0AAF6YJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ25#function" }, { "database": "UniProtKB", "id": "ARBA00058129", "url": "https://www.uniprot.org/uniprotkb/ARBA00058129#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58D34", "url": "https://www.uniprot.org/uniprotkb/Q58D34" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PI16", "url": "https://www.uniprot.org/uniprotkb/Q58D34", "locus": { "chromosome": "23", "start_pos": 10875472, "end_pos": 10861191, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002092", "url": "https://www.ensembl.org/id/ENSBTAG00000002092" } ] } } ], "crossref": [ { "id": "Q58D34", "url": "https://alphafold.ebi.ac.uk/entry/Q58D34", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002092", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002092", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05559", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05559", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507058", "url": 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"Q58D34", "url": "https://www.orthodb.org/?gene=Q58D34", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10334", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10334", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00188", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00188", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001019658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019658", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YJ25", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YJ25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJ25-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D34", "url": "https://www.uniprot.org/uniprotkb/Q58D34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D34-1", "url": "https://www.uniprot.org/uniprotkb/Q58D34-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHGSGSLLACLLPPLLLLGAAPGPAGALSEEEKHVMVELHNLYRTQVSPPATNMLQMRWDEELAAFAKAYAQQCVWGHNKERGRRGENLFAITGEGLDVPLAMEEWHHEREHYNLSAISCAAGQMCGHYTQVVWAKTERIGCGSHFCEKLQGVEETNIHLLVCNYEPPGNVKGQRPYQEGTPCSQCPLGYHCKNSLCEPIRGPEEAQDLSSLVPEAPSSLATEASSSRREGIDSSLATEPPPFLVTEVSGSLATKVLSSVETKAPSSLVTEDSPSMATKTPLSLATKVPSVLATHSLLSLDKRPATLLPKSTHDPIPKSADKEASSTRMPSRIPESSLHPKISLMGTREPLPLSQEEGEAEAELAHCSEILASVFPAQEKPGELQTTLKHKGHSSSKSLSNSPSASATANAVGGRTLALQSSLPDAEGPGKHGFRSGSNASPGHVGGLLLGLLLLLPLVLAGIF", "length": 464, "header": "sp|Q58D34-1|PI16_BOVIN Isoform 1 of Peptidase inhibitor 16 OS=Bos taurus OX=9913 GN=PI16 PE=2 SV=1 CANONICAL=Q58D34-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YJ25-1", "url": "https://www.uniprot.org/uniprotkb/Q58D34/entry#A0AAF6YJ25-1", "sequence": { "sequence": "MHGSGSLLACLLPPLLLLGAAPGPAGALSEEEKHVMVELHNLYRTQVSPPATNMLQMRWDEELAAFAKAYAQQCVWGHNKERGRRGENLFAITGEGLDVPLAMEEWHHEREHYNLSAISCAAGQMCGHYTQVVWAKTERIGCGSHFCEKLQGVEETNIHLLVCNYEPPGNVKGQRPYQEGTPCSQCPLGYHCKNSLCEPIRGPEEAQDLSSLVPEAPSSLATEASSSRREGIDSSLATEPPPFLVTEVSGSLATKVLSSVETKAPSSLVTEDSPSMATKTPLSLATKVPSVLATHSLLSLDKRPATLLPKSTHDPIPKSADKEASSTRMPSRIPESSLHPKISLMGTREPLPLSQEEGEAEAELAHCSEILASVFPAQEKPGELQTTLKHKGHSSSKSLSNSPSASATANAVGGRTLALQSSLPGTAKDYFPK", "length": 433, "header": "tr|A0AAF6YJ25-1|PI16_BOVIN Computationally mapped isoform of Peptidase inhibitor 16 OS=Bos taurus OX=9913 GN=PI16 PE=2 SV=1 CANONICAL=Q58D34-1" }, "locus": { "chromosome": "23", "start_pos": 10874468, "end_pos": 10861251, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002703.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002703.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002703.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002703.4" } ] } }, { "isoform_ac": "Q58D34-1", "url": "https://www.uniprot.org/uniprotkb/Q58D34/entry#Q58D34-1", "sequence": { "sequence": "MHGSGSLLACLLPPLLLLGAAPGPAGALSEEEKHVMVELHNLYRTQVSPPATNMLQMRWDEELAAFAKAYAQQCVWGHNKERGRRGENLFAITGEGLDVPLAMEEWHHEREHYNLSAISCAAGQMCGHYTQVVWAKTERIGCGSHFCEKLQGVEETNIHLLVCNYEPPGNVKGQRPYQEGTPCSQCPLGYHCKNSLCEPIRGPEEAQDLSSLVPEAPSSLATEASSSRREGIDSSLATEPPPFLVTEVSGSLATKVLSSVETKAPSSLVTEDSPSMATKTPLSLATKVPSVLATHSLLSLDKRPATLLPKSTHDPIPKSADKEASSTRMPSRIPESSLHPKISLMGTREPLPLSQEEGEAEAELAHCSEILASVFPAQEKPGELQTTLKHKGHSSSKSLSNSPSASATANAVGGRTLALQSSLPDAEGPGKHGFRSGSNASPGHVGGLLLGLLLLLPLVLAGIF", "length": 464, "header": "sp|Q58D34-1|PI16_BOVIN Isoform 1 of Peptidase inhibitor 16 OS=Bos taurus OX=9913 GN=PI16 PE=2 SV=1 CANONICAL=Q58D34-1" }, "locus": { "chromosome": "23", "start_pos": 10872232, "end_pos": 10861251, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047585.5", "url": "https://www.ensembl.org/id/ENSBTAT00000047585.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044778.3", "url": "https://www.ensembl.org/id/ENSBTAP00000044778.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 114, "start_aa": "Asn", "end_pos": 114, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn114", "evidence": [ { "id": "Q58D34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D34#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58D34", "url": "https://www.uniprot.org/uniprotkb/Q58D34" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:507058", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507058", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6UXB8-1", "protein_name": "Peptidase inhibitor 16", "gene_name": "PI16", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHGSCSFLMLLLPLLLLLVATTGPVGALTDEEKRLMVELHNLYRAQVSPTASDMLHMRWDEELAAFAKAYARQCVWGHNKERGRRGENLFAITDEGMDVPLAMEEWHHEREHYNLSAATCSPGQMCGHYTQVVWAKTERIGCGSHFCEKLQGVEETNIELLVCNYEPPGNVKGKRPYQEGTPCSQCPSGYHCKNSLCEPIGSPEDAQDLPYLVTEAPSFRATEASDSRKMGTPSSLATGIPAFLVTEVSGSLATKALPAVETQAPTSLATKDPPSMATEAPPCVTTEVPSILAAHSLPSLDEEPVTFPKSTHVPIPKSADKVTDKTKVPSRSPENSLDPKMSLTGARELLPHAQEEAEAEAELPPSSEVLASVFPAQDKPGELQATLDHTGHTSSKSLPNFPNTSATANATGGRALALQSSLPGAEGPDKPSVVSGLNSGPGHVWGPLLGLLLLPPLVLAGIF", "length": 463 }, "evidence": [ { "id": "Q58D34", "url": "https://omabrowser.org/oma/group/Q58D34/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9ET66-1", "protein_name": "Peptidase inhibitor 16", "gene_name": "Pi16", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHGSCSPWVMLPPPLLLLLLLIATGPTTALTEDEKQTMVDLHNQYRAQVSPPASDMLQMRWDDELAAFAKAYAQKCVWGHNKERGRRGENLFAITDEGMDVPLAVGNWHEEHEYYNFSTATCDPNQMCGHYTQVVWSKTERIGCGSHFCETLQGVEEANIHLLVCNYEPPGNVKGRKPYQEGTPCSQCPLGYSCENSLCEPMRNPEKAQDSPPRVTEVPSTRATEAPSSRETGTPSLATSETLHFSVTKVSDSLATESSPAVETKAPSSLATEGPSSMATEAQAFVTEVPLVSARHMQPSVDEGPVNFLTSTHIPVPKSMDEEASKSSATSVSPKKSLYPKMSLTESGESVPQIQEEAEPKDELSEPEAILPEAEAAPTEAEVELREPEAESPKAESPEAEAESPLSSEALVPVLPAQERGGQKASLEHSGHPASPSLPTFPSASGNATGGRTLALQSSWTGAENPEKADWDLKNSAHVWGPFLGLLLPSLLLLAGMV", "length": 498 }, "evidence": [ { "id": "Q58D34", "url": "https://omabrowser.org/oma/group/Q58D34/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q58D34", "url": "https://www.uniprot.org/uniprotkb/Q58D34" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q58D34", "url": "https://www.uniprot.org/uniprotkb/Q58D34" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "peptidase inhibitor activity", "id": "GO:0030414", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030414", "evidence": [ { "database": "UniProtKB", "id": "Q58D34", "url": "https://www.uniprot.org/uniprotkb/Q58D34" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" }, { "start_pos": 439, "end_pos": 441, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58D34-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 464, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58D34-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58D34" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 114 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 114, "end_pos": 116 }, { "start_pos": 439, "end_pos": 441 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBK9-1", "uniprot_ac": "Q3ZBK9", "uniprot_id": "GP171_BOVIN", "mass": { "chemical_mass": 36780.0, "monoisotopic_mass": 36780.0 }, "refseq": { "ac": "NP_001070470", "name": "G-protein coupled receptor 171", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070470" }, "gene_names": [ { "name": "GPR171", "type": "recommended", "evidence": [ { "id": "Q3ZBK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK9" } ] }, { "name": "GPR171", "type": "synonym", "evidence": [ { "id": "NP_001070470", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070470" } ] } ], "protein_names": [ { "name": "G protein-coupled receptor 171", "type": "recommended", "evidence": [ { "id": "Q3ZBK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK9/entry#names_and_taxonomy" } ] }, { "name": "G-protein coupled receptor 171", "type": "synonym", "evidence": [ { "id": "NP_001070470", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070470" } ] }, { "name": "probable G-protein coupled receptor 171", "type": "synonym", "evidence": [ { "id": "NP_001070470", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070470" } ] } ], "function": [ { "annotation": "G protein-coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to bigLEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception. Acts as a negative regulator T cell function.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK9#function" }, { "database": "UniProtKB", "id": "Q8BG55", "url": "https://www.uniprot.org/uniprotkb/Q8BG55#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPR171", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK9", "locus": { "chromosome": "1", "start_pos": 116903298, "end_pos": 116891720, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009848", "url": "https://www.ensembl.org/id/ENSBTAG00000009848" } ] } } ], "crossref": [ { "id": "Q3ZBK9", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBK9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009848", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009848", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15167", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15167", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "767929", "url": "https://www.ncbi.nlm.nih.gov/gene/767929", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048077", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048077", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767929", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767929", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EPFTYFY", "url": "https://omabrowser.org/oma/group/EPFTYFY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBK9", "url": "https://www.orthodb.org/?gene=Q3ZBK9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24233", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24233", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24233:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24233:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070470", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YU16", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YU16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YU16-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBK9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTNSSTFCPVYRDLEPFTYFFYLVFLIGIIGSCFATWAFIQKNTNHRCVSIYLINLLTADFLLTLALPVKITVDLGVAPWKLRIFHCQVTACLIYINMYLSIIFLAFVSIDRCLQLTYSCKIYRIQEPGFAKMISAVVWLMVLLIMVPNMIIPIKDIKEKPNVGCMEFKSEFGRNWHLLTNFISIAIFFNFSAIILISNCLVIRQLYRNKDNENYPNVKRALISILLVTTGYIICFVPYHIVRIPYTLSQTEVISDCSTRISLFKAKEATLLLAVSNLCFDPILYYHLSKAFRLKITETFASHKESKAQKEKPRSENNA", "length": 319, "header": "sp|Q3ZBK9-1|GP171_BOVIN Isoform 1 of G protein-coupled receptor 171 OS=Bos taurus OX=9913 GN=GPR171 PE=2 SV=1 CANONICAL=Q3ZBK9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YU16-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK9/entry#A0AAF6YU16-1", "sequence": { "sequence": "MTNSSTFCPVYRDLEPFTYFFYLVFLIGIIGSCFATWAFIQKNTNHRCVSIYLINLLTADFLLTLALPVKITVDLGVAPWKLRIFHCQVTACLIYINMYLSIIFLAFVSIDRCLQLTYSCKIYRIQEPGFAKMISAVVWLMVLLIMVPNMIIPIKDIKEKPNVGCMEFKSEFGRNWHLLTNFISIAIFFNFSAIILISNCLVIRQLYRNKDNENYPNVKRALISILLVTTGYIICFVPYHIVRIPYTLSQTEVISDCSTRISLFKAKEATLLLAVSNLCFDPILYYHLSKAFRLKITETFASHKESKAQKEKPSFSPLTDILLPREGLAFSQDSPGMGEKI", "length": 341, "header": "tr|A0AAF6YU16-1|GP171_BOVIN Computationally mapped isoform of G protein-coupled receptor 171 OS=Bos taurus OX=9913 GN=GPR171 PE=2 SV=1 CANONICAL=Q3ZBK9-1" }, "locus": { "chromosome": "1", "start_pos": 116902557, "end_pos": 116897078, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012983.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012983.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012983.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012983.6" } ] } }, { "isoform_ac": "Q3ZBK9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK9/entry#Q3ZBK9-1", "sequence": { "sequence": "MTNSSTFCPVYRDLEPFTYFFYLVFLIGIIGSCFATWAFIQKNTNHRCVSIYLINLLTADFLLTLALPVKITVDLGVAPWKLRIFHCQVTACLIYINMYLSIIFLAFVSIDRCLQLTYSCKIYRIQEPGFAKMISAVVWLMVLLIMVPNMIIPIKDIKEKPNVGCMEFKSEFGRNWHLLTNFISIAIFFNFSAIILISNCLVIRQLYRNKDNENYPNVKRALISILLVTTGYIICFVPYHIVRIPYTLSQTEVISDCSTRISLFKAKEATLLLAVSNLCFDPILYYHLSKAFRLKITETFASHKESKAQKEKPRSENNA", "length": 319, "header": "sp|Q3ZBK9-1|GP171_BOVIN Isoform 1 of G protein-coupled receptor 171 OS=Bos taurus OX=9913 GN=GPR171 PE=2 SV=1 CANONICAL=Q3ZBK9-1" }, "locus": { "chromosome": "1", "start_pos": 116898034, "end_pos": 116897078, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124275.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124275.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094704.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094704.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 3, "start_aa": "Asn", "end_pos": 3, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn3", "evidence": [ { "id": "Q3ZBK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK9#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:767929", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767929", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AG07-1", "protein_name": "G-protein coupled receptor 171", "gene_name": "GPR171", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTNSSIFCPVYRDLEPFTYFFYLVFLVGIIGSCFATWAFLQKNANHRCVSIYLINLLTADFLLTLALPVKIIVDLGVAPWKLKIFHCQVTACLIYINMYLSIIFLAFVSIDRCLQLTYSCKIYRIQEPGFAKMISAVVWLMVLVIMVPNMVIPIKEIKEKPTVGCMEFKTEFGKNWHLLTNFICIAIFLNFSGIILISNCLVIRQLYRNKDNENYPNVKSTLINILLVTTGYIICFVPYHSVRIPYTLSQTEVISDCPTRISLFRAKEATLLLAVSNLCFDPILYYHLSRAFRLRVNETFASHKESKVQKEKSSCENNA", "length": 319 }, "evidence": [ { "id": "Q3ZBK9", "url": "https://omabrowser.org/oma/group/Q3ZBK9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2LHS9-1", "protein_name": "G-protein coupled receptor 171", "gene_name": "Gpr171", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTNSSLFCPVYRDLEPFTYFFYLVFLIGIIGSCFATWAFIQKTTNHRCVSIYLINLLTADFLLTLALPVKIVVDLGVAPWKLRIFHCQVTACLIYINMYLSIIFLAFVSIDRCLQLIHSCKIYRIQEPGFAKMISTVVWLMVLLIMVPNMLIPIKDIKEKSNVGCMEFKKEFGKNWHLLTNFICVAIFLNFSAIILISNFLVIRQLYRNRDDANYPNVKTALINILLVTAGYIICFVPYHAVRIPYTLSQTEVISDCSTRISLFKAKEATLLLAVSNLCFDPILYYHLSKAFRLKVTETFASPKKTKAQKEKSRCENDV", "length": 319 }, "evidence": [ { "id": "Q3ZBK9", "url": "https://omabrowser.org/oma/group/Q3ZBK9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0X174-1", "protein_name": "G-protein coupled receptor 171", "gene_name": "GPR171", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPNNASQCYIKTELQPFTYFYYLIFLTGFLGSCFALWAFTQKGQKQKCMSIYLTNLLTADFLLTLALPVKIIVDLGVAPWKLQIFHCQVTACLIYLNMYLSIIFLGFVSMDRYLQLMHSSKIYRIQEPGFAKILSAVVWTMVLLITVPNMAIPIKTIEERPNARCIDFKTKFGRDWHVFTNFVCTAIFLNFSAVILISNFLVVRQLYQNKYSESYTNVKKALVSILLLTAAYLLCFLPYHVVRIPYTLSQSNAITSCSLKQTLFHAKESTLLFAVSNLCFDPILYYRLSNVFRLKVTEAFMASKQAKVSTDEEAQHRSEQWVQRY", "length": 325 }, "evidence": [ { "id": "Q3ZBK9", "url": "https://omabrowser.org/oma/group/Q3ZBK9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A4Q2-1", "protein_name": "G protein-coupled receptor 171", "gene_name": "Gpr171", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTNSSMFCPIYRDLEPFTYFFYLVYLIGIIGSCFATWAFIQKSTNHRCVSIYLINLLTADFLLTLALPVKIVVDLGVAPWKLRIFHCQVTACLIYINMYLSIIFLAFVSIDRCLQLVHSCKIYRIQEPGFAKMISAVVWLMVLLIMVPNMVIPIKNIKEKSNVGCMEFKREFGKNWHLLTNFICVAIFLNFSAIILISNFLVIRQLYRNRDNANYPSVKSALLNILLVTASYIICFVPYHAVRIPYTLSQTEVISDCSTRIALFKAKEATLLLAVSNLCFDPILYYHLSKAFRLKVTETFASPQKMKAREEKPRRENDVQSTGSAC", "length": 326 }, "evidence": [ { "id": "Q3ZBK9", "url": "https://omabrowser.org/oma/group/Q3ZBK9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O14626-1", "protein_name": "G protein-coupled receptor 171", "gene_name": "GPR171", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTNSSFFCPVYKDLEPFTYFFYLVFLVGIIGSCFATWAFIQKNTNHRCVSIYLINLLTADFLLTLALPVKIVVDLGVAPWKLKIFHCQVTACLIYINMYLSIIFLAFVSIDRCLQLTHSCKIYRIQEPGFAKMISTVVWLMVLLIMVPNMMIPIKDIKEKSNVGCMEFKKEFGRNWHLLTNFICVAIFLNFSAIILISNCLVIRQLYRNKDNENYPNVKKALINILLVTTGYIICFVPYHIVRIPYTLSQTEVITDCSTRISLFKAKEATLLLAVSNLCFDPILYYHLSKAFRSKVTETFASPKETKAQKEKLRCENNA", "length": 319 }, "evidence": [ { "id": "Q3ZBK9", "url": "https://omabrowser.org/oma/group/Q3ZBK9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BG55-1", "protein_name": "G protein-coupled receptor 171", "gene_name": "Gpr171", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTNSSTFCPVYRDLEPFTYFFYLVFLIGIIGSCFATWAFIQKTTNHRCVSIYLINLLTADFLLTLALPVKIIVDLGVAPWKLRIFHCQVTACLIYINMYLSIIFLAFVSIDRCLQLIHSCKIYRIQEPGFAKMISAVVWLMVLLIMVPNMVIPIKDIKEKSNVGCMEFKKEFGRNWHLLTNFICVAIFLNFSVIILISNFLAIRQLYRNRDNTNYPSVKSALLHILLVTASYIICFVPYHAVRIPYTLSQTEVISDCSTRIALFKAKEATLLLAVSNLCFDPILYYHLSKAFRLKVTETFASPKKSKPLEERLRSENDV", "length": 319 }, "evidence": [ { "id": "Q3ZBK9", "url": "https://omabrowser.org/oma/group/Q3ZBK9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK9" } ], "pmid": "" }, { "name": "regulation of sensory perception of pain", "id": "GO:0051930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051930", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK9" } ], "pmid": "" }, { "name": "adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "id": "GO:0007188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007188", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK9" } ], "pmid": "" }, { "name": "regulation of feeding behavior", "id": "GO:0060259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060259", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "G protein-coupled peptide receptor activity", "id": "GO:0008528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008528", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK9" } ], "pmid": "" }, { "name": "G protein-coupled purinergic nucleotide receptor activity", "id": "GO:0045028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045028", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK9" } ], "pmid": "" }, { "name": "neuropeptide receptor activity", "id": "GO:0008188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008188", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK9" } ], "pmid": "" }, { "name": "neuropeptide binding", "id": "GO:0042923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042923", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBK9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBK9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBK9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 319, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBK9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBK9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 3 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 190, "end_pos": 192 }, { "start_pos": 3, "end_pos": 5 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 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"exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q5EA37-1", "uniprot_ac": "Q5EA37", "uniprot_id": "YJU2B_BOVIN", "mass": { "chemical_mass": 45481.0, "monoisotopic_mass": 45481.0 }, "refseq": { "ac": "NP_001069812", "name": "probable splicing factor YJU2B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069812" }, "gene_names": [ { "name": "YJU2B", "type": "recommended", "evidence": [ { "id": "Q5EA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA37" } ] }, { "name": "CCDC130", "type": "synonym", "evidence": [ { "id": "NP_001069812", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069812" }, { "id": "Q5EA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA37" } ] }, { "name": "YJU2B", "type": "synonym", "evidence": [ { "id": "NP_001069812", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069812" } ] } ], "protein_names": [ { "name": "Probable splicing factor YJU2B", "type": "recommended", "evidence": [ { "id": "Q5EA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA37/entry#names_and_taxonomy" } ] }, { "name": "Coiled-coil domain-containing protein 130", "type": "synonym", "evidence": [ { "id": "Q5EA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA37/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain containing 130", "type": "synonym", "evidence": [ { "id": "NP_001069812", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069812" } ] }, { "name": "coiled-coil domain-containing protein 130", "type": "synonym", "evidence": [ { "id": "NP_001069812", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069812" } ] }, { "name": "probable splicing factor YJU2B", "type": "synonym", "evidence": [ { "id": "NP_001069812", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069812" } ] } ], "function": [ { "annotation": "May be involved in mRNA splicing.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YYC8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYC8#function" }, { "database": "UniProtKB", "id": "ARBA00037140", "url": "https://www.uniprot.org/uniprotkb/ARBA00037140#function" }, { "database": "UniProtKB", "id": "Q5EA37", "url": "https://www.uniprot.org/uniprotkb/Q5EA37#function" }, { "database": "UniProtKB", "id": "Q9BW85", "url": "https://www.uniprot.org/uniprotkb/Q9BW85#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA37", "url": "https://www.uniprot.org/uniprotkb/Q5EA37" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "YJU2B", "url": "https://www.uniprot.org/uniprotkb/Q5EA37", "locus": { "chromosome": "7", "start_pos": 11886460, "end_pos": 11899523, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002516", "url": "https://www.ensembl.org/id/ENSBTAG00000002516" } ] } } ], "crossref": [ { "id": "Q5EA37", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA37", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002516", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002516", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614791", "url": "https://www.ncbi.nlm.nih.gov/gene/614791", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614791", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614791", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RNMSVWD", "url": "https://omabrowser.org/oma/group/RNMSVWD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EA37", "url": "https://www.orthodb.org/?gene=Q5EA37", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12111", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12111", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12111:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12111:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04502", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04502", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069812", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6YYC8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YYC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YYC8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA37", "url": "https://www.uniprot.org/uniprotkb/Q5EA37", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA37-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA37-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA37-2", "url": "https://www.uniprot.org/uniprotkb/Q5EA37-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGERKGVNKYYPPDFNPEKHGSLNRYHNSHPLRERARKLSQGILIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGNYYTTPIYRFRMKCHLCVNYIEMQTDPANCDYVIVSGAQRKEERWDMEDNEQVLTTEHEKKQKLEMDAMFRLEHGEADRSTLKKALPTLSHIQEAQSAWKDDFALNSMLRKRFREKKKAMQEEEERDQALQAKASLAIPLVPETEDDRRLAALLKFHTLDSYEDKQKLKRTEIISRSWFPSTPGASASSSSSSKTNSVLKKLAQNRRATPTSSPVTMGHLGIVRRRSREVPESPQHVAETFKSGEPQLPEGTNQNRPVSPQDCSLETAETPKNSSALGQEESCQDRPQPPPDTSPEAPNPQDTPQPCSLGSSLVADYSGSESE", "length": 400, "header": "sp|Q5EA37-1|YJU2B_BOVIN Isoform 1 of Probable splicing factor YJU2B OS=Bos taurus OX=9913 GN=YJU2B PE=2 SV=1 CANONICAL=Q5EA37-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YYC8-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA37/entry#A0AAF6YYC8-1", "sequence": { "sequence": "MARSTDTTTATPFGSGLGSCPRASSSSGVRYNAEKKKVGNYYTTPIYRFRMKCHLCVNYIEMQTDPANCDYVIVSGAQRKEERWDMEDNEQVLTTEHEKKQKLEMDAMFRLEHGEADRSTLKKALPTLSHIQEAQSAWKDDFALNSMLRKRFREKKKAMQEEEERDQALQAKASLAIPLVPETEDDRRLAALLKFHTLDSYEDKQKLKRTEIISRSWFPSTPGASASSSSSSKTNSVLKKLAQNRRATPTSSPVTMGHLGIVRRRSREVPESPQHVAETFKSGEPQLPEGTNQNRPVSPQDCSLETAETPKNSSALGQEESCQDRPQPPPDTSPEAPNPQDTPQPCSLGSSLVADYSGSESE", "length": 362, "header": "tr|A0AAF6YYC8-1|YJU2B_BOVIN Computationally mapped isoform of Probable splicing factor YJU2B OS=Bos taurus OX=9913 GN=YJU2B PE=2 SV=1 CANONICAL=Q5EA37-1" }, "locus": { "chromosome": "7", "start_pos": 11892699, "end_pos": 11886682, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017226.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017226.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017226.7", "url": "https://www.ensembl.org/id/ENSBTAP00000017226.7" } ] } }, { "isoform_ac": "Q5EA37-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA37/entry#Q5EA37-1", "sequence": { "sequence": "MGERKGVNKYYPPDFNPEKHGSLNRYHNSHPLRERARKLSQGILIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGNYYTTPIYRFRMKCHLCVNYIEMQTDPANCDYVIVSGAQRKEERWDMEDNEQVLTTEHEKKQKLEMDAMFRLEHGEADRSTLKKALPTLSHIQEAQSAWKDDFALNSMLRKRFREKKKAMQEEEERDQALQAKASLAIPLVPETEDDRRLAALLKFHTLDSYEDKQKLKRTEIISRSWFPSTPGASASSSSSSKTNSVLKKLAQNRRATPTSSPVTMGHLGIVRRRSREVPESPQHVAETFKSGEPQLPEGTNQNRPVSPQDCSLETAETPKNSSALGQEESCQDRPQPPPDTSPEAPNPQDTPQPCSLGSSLVADYSGSESE", "length": 400, "header": "sp|Q5EA37-1|YJU2B_BOVIN Isoform 1 of Probable splicing factor YJU2B OS=Bos taurus OX=9913 GN=YJU2B PE=2 SV=1 CANONICAL=Q5EA37-1" }, "locus": { "chromosome": "7", "start_pos": 11895871, "end_pos": 11886682, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003269.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003269.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003269.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003269.6" } ] } }, { "isoform_ac": "Q5EA37-2", "url": "https://www.uniprot.org/uniprotkb/Q5EA37/entry#Q5EA37-2", "sequence": { "sequence": "MGERKGVNKYYPPDFNPEKHGSLNRYHNSHPLRERARKLSQGILIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGNYYTTPIYRFRMKCHLCVNYIEMQTDPANCDYVIVSGAQRKEERWDMEDNEQVLTTEHEKKQKLEMDAMFRLEHGEADRSTLKKALPTLSHIQEAQSAWKDDFALNSMLRKRFREKKKAMQEEEERDQALQAKASLAIPLVPETEDDRRLAALLKFHTLDSYEDKQKLKRTEIISRSWFPSTPGASASSSSSSKTNSVLKKLAQNRRATPTSSPVTMGHLGIVRRRSREVPESPQHVAETFKSGEPQLPEGTNQNRPVSPQDCSLETAETPKNSSALGQEESCQDRPQPPPDTSLVADYSGSESE", "length": 382, "header": "sp|Q5EA37-2|YJU2B_BOVIN Isoform 2 of Probable splicing factor YJU2B OS=Bos taurus OX=9913 GN=YJU2B PE=2 SV=1 CANONICAL=Q5EA37-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 259, "start_aa": "Thr", "end_pos": 259, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr259", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 310, "end_pos": 310, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA37", "url": "https://www.uniprot.org/uniprotkb/Q5EA37" } ], "site_lbl": "Ser310" }, { "start_pos": 40, "end_pos": 40, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA37", "url": "https://www.uniprot.org/uniprotkb/Q5EA37" } ], "site_lbl": "Ser40" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA37", "url": "https://www.uniprot.org/uniprotkb/Q5EA37" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:614791", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614791", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P13994-1", "protein_name": "Probable splicing factor YJU2B", "gene_name": "YJU2B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGERKGVNKYYPPDFNPEKHGSLNRYHNSHPLRERARKLSQGILIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGNYYTTPIYRFRMKCHLCVNYIEMQTDPANCDYVIVSGAQRKEERWDMADNEQVLTTEHEKKQKLETDAMFRLEHGEADRSTLKKALPTLSHIQEAQSAWKDDFALNSMLRRRFREKKKAIQEEEERDQALQAKASLTIPLVPETEDDRKLAALLKFHTLDSYEDKQKLKRTEIISRSWFPSAPGSASSSKVSGVLKKLAQSRRTALATSPITVGDLGIVRRRSRDVPESPQHAADTPKSGEPRVPEEAAQDRPMSPGDCPPETTETPKCSSPRGQEGSRQDKPLSPAGSSQEAADTPDTRHPCSLGSSLVADYSDSESE", "length": 396 }, "evidence": [ { "id": "Q5EA37", "url": "https://omabrowser.org/oma/group/Q5EA37/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54TR4-1", "protein_name": "Coiled-coil domain-containing protein 130 homolog", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MAERKATNKYYPPDWDPSKGSINQYRGQHHLRDRARKIDQGILIIRFEMPFSVWCLGCECHIGMGVRFNAEKKTVDKYFTSNIYSFKMKCHQCSNQFEIQNDPKNTDYKLISGLKKRIEQFNPEDSELPSSFIIKYDDNNNNNNNNNNNDNNDTLLKLENKKLDIEKGKKESTQLEKLQEIMTNRTINDYQLSSIMRKSFREKKKEDQIELERQKSKGIMIPLLKENQDDIDTAKDIDFNSNSLKRKLDESNKLKRELIKNESILKSTNNVNNNNNVNNNNNNNNNNKIEAIIRKKSKIDPSLFNNNVNKNKSKVNETFTSNLFK", "length": 325 }, "evidence": [ { "id": "Q5EA37", "url": "https://omabrowser.org/oma/group/Q5EA37/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q66I85-1", "protein_name": "Probable splicing factor YJU2B", "gene_name": "yju2b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGERKGVNKWYPPDFDPAKHGSINGYYKTHPLRERARKLSQGILIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGNYYTTPIYRFRMKCHLCVNYIEMQTDPATCDYVIVSGAQRKEERWDMAENEQILTTERNEKEKLETDAMYKLDHGGKDKEKLRAAIPSLNELQEHQSGWKDDFQLNSALRRKFRTEKKVIAEEEEKDNAVRLRTGLSIPLVPEREEDKKLASLLTFQSPDSYEDKKQWKRQEISSRSWFNSPSSAAGGAAGSLLQKLGQQGRGAAVAKALSSSTSTLPILVRRKSESSKSETNNTMSTILPVDTHPAAKDTDATDLPSIVNNINVSINTDINSCTTDACKASSSSEEENSIDSCATGKSLVADYSDSDSGSEV", "length": 390 }, "evidence": [ { "id": "Q5EA37", "url": "https://omabrowser.org/oma/group/Q5EA37/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q7K0F0-1", "protein_name": "Coiled-coil domain-containing protein 130 homolog", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGERKGQNKYYPPDYDPKKGGLNKFQGTHALRERARKIHLGIIIIRFEMPYNIWCDGCKNHIGMGVRYNAEKTKVGMYYTTPVFKFRMKCHLCDNHFEIQTDPGNLDYVILSGARRQENRWDPLQNEQVVPETKEVQKRLFDDAMYKLEHQAKDAKAGADARPVLQKLVERNMSVWDDSYMANSRLRAEFRQQKKEINGQQELDRQLLAKSSLDIALLPETTQDREMAALMKLQTKSALERESEQRLELLMRPALPGATVTTFGGLKRQKVLNTQLQVQDLGIRRKKLEETTSSATNEKPISLVGDYSSSDNDSNG", "length": 316 }, "evidence": [ { "id": "Q5EA37", "url": "https://omabrowser.org/oma/group/Q5EA37/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9C609-1", "protein_name": "Coiled-coil protein (DUF572)", "gene_name": "CWC16A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSTLSAARADNFYYPPEWTPDQGSLNKFQGQHPLRERAKKIGEGILVIRFEMPYNIWCGGCSSMIAKGVRFNAEKKQVGNYYSTKIWSFAMKSPCCKHEIVIQTDPQNCEYVITSGAQKKVEEYEAEDAETMELTAEQEKGKLADPFYRLEHQEVDLQKKKAAEPLLVRLQRVSDARHADDYSLNKALRAQLRRHRKRVAEEETASRKLGLGIRLLPKSEEDIKAASNVKFKSKFDKNRKDKRALIHASSIFPESSYSSSKKRMELEAKRRKISAASASSLLRGGFKASSLSTNPSASKPKVSSVSVRKL", "length": 310 }, "evidence": [ { "id": "Q5EA37", "url": "https://omabrowser.org/oma/group/Q5EA37/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9D516-1", "protein_name": "Probable splicing factor YJU2B", "gene_name": "Yju2b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGERKGQNKYYPPDFNPEKHGSLNRYHNSHPLRERARKLSQGILVIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGNYYTTPIYRFRMKCHLCVNYIEMQTDPANCDYVIVSGASRKEERWDMEDNEQVLTTEHEKKEKLETDAMFRLEHGEADRSTLKKALPTLSHIQEAQNAWKDDFALNSMLRRHFREKKKAMQEEEEKDQALQAKASLAIPLVPESEDDRRLAALLRLHTLDSYEDKQRMKRTEIIHRSWFPSAQGPSASSSKASSVLKKLCQGRRPPPSSTGTVGDLGIVRRKSRDVPESPQCAADNSLSEEQRRPPGTTQGSKTLEEAAEASRTSKTSESKRNCSDQAFPLGSSQEDLLNPNTPNASLVADYSDSESE", "length": 385 }, "evidence": [ { "id": "Q5EA37", "url": "https://omabrowser.org/oma/group/Q5EA37/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "response to virus", "id": "GO:0009615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009615", "evidence": [ { "database": "UniProtKB", "id": "Q5EA37", "url": "https://www.uniprot.org/uniprotkb/Q5EA37" } ], "pmid": "" }, { "name": "mRNA cis splicing, via spliceosome", "id": "GO:0045292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045292", "evidence": [ { "database": "UniProtKB", "id": "Q5EA37", "url": "https://www.uniprot.org/uniprotkb/Q5EA37" } ], "pmid": "" }, { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "Q5EA37", "url": "https://www.uniprot.org/uniprotkb/Q5EA37" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "post-mRNA release spliceosomal complex", "id": "GO:0071014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071014", "evidence": [ { "database": "UniProtKB", "id": "Q5EA37", "url": "https://www.uniprot.org/uniprotkb/Q5EA37" } ], "pmid": "" }, { "name": "U2-type spliceosomal complex", "id": "GO:0005684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005684", "evidence": [ { "database": "UniProtKB", "id": "Q5EA37", "url": "https://www.uniprot.org/uniprotkb/Q5EA37" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA37-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 400, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA37-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA37" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 259 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 40, 310 ], "sequon_annotation_sites": [ { 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{ "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { 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"count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9F6-1", "uniprot_ac": "Q5E9F6", "uniprot_id": "VPS72_BOVIN", "mass": { "chemical_mass": 40651.0, "monoisotopic_mass": 40651.0 }, "refseq": { "ac": "NP_001015658", "name": "vacuolar protein sorting-associated protein 72 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015658" }, "gene_names": [ { "name": "VPS72", "type": "recommended", "evidence": [ { "id": "Q5E9F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9F6" } ] }, { "name": "TCFL1", "type": "synonym", "evidence": [ { "id": "NP_001015658", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015658" }, { "id": "Q5E9F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9F6" } ] }, { "name": "VPS72", "type": "synonym", "evidence": [ { "id": "NP_001015658", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015658" } ] } ], "protein_names": [ { "name": "Vacuolar protein sorting-associated protein 72 homolog", "type": "recommended", "evidence": [ { "id": "Q5E9F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9F6/entry#names_and_taxonomy" } ] }, { "name": "Transcription factor-like 1", "type": "synonym", "evidence": [ { "id": "Q5E9F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9F6/entry#names_and_taxonomy" } ] }, { "name": "transcription factor-like 1", "type": "synonym", "evidence": [ { "id": "NP_001015658", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015658" } ] }, { "name": "vacuolar protein sorting-associated protein 72 homolog", "type": "synonym", "evidence": [ { "id": "NP_001015658", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015658" } ] } ], "function": [ { "annotation": "Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6Z4K2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4K2#function" }, { "database": "UniProtKB", "id": "ARBA00002050", "url": "https://www.uniprot.org/uniprotkb/ARBA00002050#function" }, { "database": "UniProtKB", "id": "Q5E9F6", "url": "https://www.uniprot.org/uniprotkb/Q5E9F6#function" }, { "database": "UniProtKB", "id": "Q15906", "url": "https://www.uniprot.org/uniprotkb/Q15906#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9F6", "url": "https://www.uniprot.org/uniprotkb/Q5E9F6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VPS72", "url": "https://www.uniprot.org/uniprotkb/Q5E9F6", "locus": { "chromosome": "3", "start_pos": 19636725, "end_pos": 19624886, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018074", "url": "https://www.ensembl.org/id/ENSBTAG00000018074" } ] } } ], "crossref": [ { "id": "Q5E9F6", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9F6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018074", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018074", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534883", "url": "https://www.ncbi.nlm.nih.gov/gene/534883", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013272", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013272", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046757", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046757", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534883", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534883", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TGPTIRY", "url": "https://omabrowser.org/oma/group/TGPTIRY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9F6", "url": "https://www.orthodb.org/?gene=Q5E9F6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13275", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13275", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13275:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13275:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05764", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05764", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08265", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08265", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015658", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6Z4K2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4K2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z4K2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4K2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9F6", "url": "https://www.uniprot.org/uniprotkb/Q5E9F6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9F6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9F6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLAGGRAPRKTAGNRLSGLLEKEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSDFDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVSTPAGSSQKTREEKALLPLELQDDGTDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITEELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDVEGLDPAPMASALAARAGTGPVIPPARCSRTFITFSDDATFEEWFPQGRTPKIPVREVCPVTHRPALYRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQKIVIK", "length": 364, "header": "sp|Q5E9F6-1|VPS72_BOVIN Isoform 1 of Vacuolar protein sorting-associated protein 72 homolog OS=Bos taurus OX=9913 GN=VPS72 PE=2 SV=1 CANONICAL=Q5E9F6-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z4K2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9F6/entry#A0AAF6Z4K2-1", "sequence": { "sequence": "MFEESGDDEYQGDQSDTEDEVDSDFDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVSTPAGSSQKTREEKALLPLELQDDGTDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITEELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDVEGLDPAPMASALAARAGTGPVIPPARCSRTFITFSDDATFEEWFPQGRTPKIPVREVCPVTHRPALYRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQKIVIK", "length": 328, "header": "tr|A0AAF6Z4K2-1|VPS72_BOVIN Computationally mapped isoform of Vacuolar protein sorting-associated protein 72 homolog OS=Bos taurus OX=9913 GN=VPS72 PE=2 SV=1 CANONICAL=Q5E9F6-1" }, "locus": { "chromosome": "3", "start_pos": 19636527, "end_pos": 19627113, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024063.5", "url": "https://www.ensembl.org/id/ENSBTAT00000024063.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024063.4", "url": "https://www.ensembl.org/id/ENSBTAP00000024063.4" } ] } }, { "isoform_ac": "Q5E9F6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9F6/entry#Q5E9F6-1", "sequence": { "sequence": "MSLAGGRAPRKTAGNRLSGLLEKEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSDFDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVSTPAGSSQKTREEKALLPLELQDDGTDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITEELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDVEGLDPAPMASALAARAGTGPVIPPARCSRTFITFSDDATFEEWFPQGRTPKIPVREVCPVTHRPALYRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQKIVIK", "length": 364, "header": "sp|Q5E9F6-1|VPS72_BOVIN Isoform 1 of Vacuolar protein sorting-associated protein 72 homolog OS=Bos taurus OX=9913 GN=VPS72 PE=2 SV=1 CANONICAL=Q5E9F6-1" }, "locus": { "chromosome": "3", "start_pos": 19636527, "end_pos": 19624943, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099191.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099191.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076858.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076858.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 129, "end_pos": 129, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9F6", "url": "https://www.uniprot.org/uniprotkb/Q5E9F6" } ], "site_lbl": "Ser129" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9F6", "url": "https://www.uniprot.org/uniprotkb/Q5E9F6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:534883", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534883", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B4J5-1", "protein_name": "Vacuolar protein sorting-associated protein 72 homolog", "gene_name": "VPS72", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSDFDIDEGDEPSSDGETEEPRRKRRVVTKAYKEPLKSLRPRKVSTPAGSSQKTREEKALLPLELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITEELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDVEGLDPTPTASALTPRPGTGPVVPPARCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPALYRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQKIVIK", "length": 364 }, "evidence": [ { "id": "Q5E9F6", "url": "https://omabrowser.org/oma/group/Q5E9F6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MFL1-1", "protein_name": "Vacuolar protein sorting-associated protein 72 homolog", "gene_name": "Vps72", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSDFDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVSTPASSSQKAREEKALLPLELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITEELNLRSLETYERLEADKKKQVHKKRKCPGPVITYHSVTVPLVGEPGPKEENVDVEGLDPAPTASALTAHAGSGPAVPPAHCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPALYRDPVTDIPYATARAFKIIREAYKKYITAHGLPPAASALGPGPPPPEPLPGSGPRALRQKIVIK", "length": 364 }, "evidence": [ { "id": "Q5E9F6", "url": "https://omabrowser.org/oma/group/Q5E9F6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "B1WC45-1", "protein_name": "Vacuolar protein sorting-associated protein 72 homolog", "gene_name": "Vps72", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSDFDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVSTPASSSQKAREEKTLLPLELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITEELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDVEGLDPAPTSSALTAHAGTGPAVPPPHCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPALYRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGAGPRALRQKIVIK", "length": 364 }, "evidence": [ { "id": "Q5E9F6", "url": "https://omabrowser.org/oma/group/Q5E9F6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F4IP06-1", "protein_name": "SWR1 complex subunit 2", "gene_name": "SWC2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": 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"sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA90-1", "uniprot_ac": "Q5EA90", "uniprot_id": "T106A_BOVIN", "mass": { "chemical_mass": 28828.0, "monoisotopic_mass": 28828.0 }, "refseq": { "ac": "NP_001014870", "name": "transmembrane protein 106A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014870" }, "gene_names": [ { "name": "TMEM106A", "type": "recommended", "evidence": [ { "id": "Q5EA90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA90" } ] }, { "name": "TMEM106A", "type": "synonym", "evidence": [ { "id": "NP_001014870", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014870" } ] } ], "protein_names": [ { "name": "Transmembrane protein 106A", "type": "recommended", "evidence": [ { "id": "Q5EA90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA90/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 106A", "type": "synonym", "evidence": [ { "id": "NP_001014870", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014870" } ] } ], "function": [ { "annotation": "Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5EA90", "url": "https://www.uniprot.org/uniprotkb/Q5EA90#function" }, { "database": "UniProtKB", "id": "Q96A25", "url": "https://www.uniprot.org/uniprotkb/Q96A25#function" }, { "database": "UniProtKB", "id": "Q8VC04", "url": "https://www.uniprot.org/uniprotkb/Q8VC04#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA90", "url": "https://www.uniprot.org/uniprotkb/Q5EA90" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM106A", "url": "https://www.uniprot.org/uniprotkb/Q5EA90", "locus": { "chromosome": "19", "start_pos": 43176485, "end_pos": 43169643, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006801", "url": "https://www.ensembl.org/id/ENSBTAG00000006801" } ] } } ], "crossref": [ { "id": "Q5EA90", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA90", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006801", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006801", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508269", "url": "https://www.ncbi.nlm.nih.gov/gene/508269", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048509", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048509", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048511", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048511", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508269", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508269", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CSYLCHS", "url": "https://omabrowser.org/oma/group/CSYLCHS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EA90", "url": "https://www.orthodb.org/?gene=Q5EA90", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28556", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28556", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28556:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28556:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07092", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07092", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21002", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21002", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014870", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6ZU26", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZU26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZU26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZU26-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A7M8", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7M8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A7M8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A7M8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA90", "url": "https://www.uniprot.org/uniprotkb/Q5EA90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA90-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA90-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGETFSQLASQKDENKLILPPNPAFGSKAASYSSMGNSRPFFSCVPCERAAGAGFVTCPTCQGSGEIPRELEKQLVALIPYGDQRLKPRHTKLSVFLAVSICLVTSSLIIFFLFPRTIAVQPVGLNSSTVATDEANVYLNITSILNISNNNYCPITVTQLTIEVLHLSLVVGQVSHSLLLHIGPLASEQMFYAVTNRINDENTYKICTWLEIKVHHVLLYIQGTLTYSYLSRSEQLVFQSYEYVDCRGNTSVPHLLVSHPP", "length": 261, "header": "sp|Q5EA90-1|T106A_BOVIN Isoform 1 of Transmembrane protein 106A OS=Bos taurus OX=9913 GN=TMEM106A PE=2 SV=1 CANONICAL=Q5EA90-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZU26-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA90/entry#A0AAF6ZU26-1", "sequence": { "sequence": "MGETFSQLASQKDENKLILPPNPAFGSKAASYSSMGNSRPFFSCVPCERAAGAGFVTCPTCQGSGEIPRELEKQLVALIPYGDQRLKPRHTKLSVFLAVSICLVTSSLIIFFLFPRTIAVQPVGLNSSTVATDEANVYLNITMFYAVTNRINDENTYKICTWLEIKVHHVLLYIQGTLTYSYLSRSEQLVFQSYEYVDCRGNTSVPHLLVSHPP", "length": 214, "header": "tr|A0AAF6ZU26-1|T106A_BOVIN Computationally mapped isoform of Transmembrane protein 106A OS=Bos taurus OX=9913 GN=TMEM106A PE=2 SV=1 CANONICAL=Q5EA90-1" }, "locus": { "chromosome": "19", "start_pos": 43175193, "end_pos": 43170879, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069834.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069834.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057529.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057529.2" } ] } }, { "isoform_ac": "A0AAF7A7M8-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA90/entry#A0AAF7A7M8-1", "sequence": { "sequence": "MGETFSQLASQKDENKLILPPNPAFGSKAASYSSMGNSRPFFSCVPCERAAGAGFVTCPTCQGSGEIPRGELLVSRLLHFPTRVLLSHRKLSVFLAVSICLVTSSLIIFFLFPRTIAVQPVGLNSSTVATDEANVYLNITSILNISNNNYCPITVTQLTIEVLHLSLVVGQVSHSLLLHIGPLASEQMFYAVTNRINDENTYKICTWLEIKVHHVLLYIQGTLTYSYLSRSEQLVFQSYEYVDCRGNTSVPHLLVSHPP", "length": 259, "header": "tr|A0AAF7A7M8-1|T106A_BOVIN Computationally mapped isoform of Transmembrane protein 106A OS=Bos taurus OX=9913 GN=TMEM106A PE=2 SV=1 CANONICAL=Q5EA90-1" }, "locus": { "chromosome": "19", "start_pos": 43175193, "end_pos": 43170879, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071059.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071059.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063987.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063987.2" } ] } }, { "isoform_ac": "Q5EA90-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA90/entry#Q5EA90-1", "sequence": { "sequence": "MGETFSQLASQKDENKLILPPNPAFGSKAASYSSMGNSRPFFSCVPCERAAGAGFVTCPTCQGSGEIPRELEKQLVALIPYGDQRLKPRHTKLSVFLAVSICLVTSSLIIFFLFPRTIAVQPVGLNSSTVATDEANVYLNITSILNISNNNYCPITVTQLTIEVLHLSLVVGQVSHSLLLHIGPLASEQMFYAVTNRINDENTYKICTWLEIKVHHVLLYIQGTLTYSYLSRSEQLVFQSYEYVDCRGNTSVPHLLVSHPP", "length": 261, "header": "sp|Q5EA90-1|T106A_BOVIN Isoform 1 of Transmembrane protein 106A OS=Bos taurus OX=9913 GN=TMEM106A PE=2 SV=1 CANONICAL=Q5EA90-1" }, "locus": { "chromosome": "19", "start_pos": 43175193, "end_pos": 43170879, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008944.8", "url": "https://www.ensembl.org/id/ENSBTAT00000008944.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008944.5", "url": "https://www.ensembl.org/id/ENSBTAP00000008944.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA90", "url": "https://www.uniprot.org/uniprotkb/Q5EA90" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:508269", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508269", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3HM07-1", "protein_name": "Transmembrane protein 106A isoform X1", "gene_name": "Tmem106a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGKAFSQVTSQQDEGKSILSANPALSSKPANYLSTGNSKPPCSGVLYARAAGAGFVICPTCQGNGEIPREQEKQLVALIPYGDRRLKPPHTKLSVFLAVIICLVTFTLTIFFLYPRSIAVYPIGLNSSMVTFDETHIRLSMTNILNISNSNFYPITVTRLTAEVLHQTSVVGQVTSSLRLHIRPLASEQMPYKVASSILDENTYKICAQLKVKVHHILLHIQGTLTCSYLSHPQQLPFESFEYVDCKENMSMPHLEIPRPA", "length": 261 }, "evidence": [ { "id": "Q5EA90", "url": "https://omabrowser.org/oma/group/Q5EA90/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LND6-1", "protein_name": "Transmembrane protein 106A", "gene_name": "TMEM106A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGETFSQLGSQKDENKSILPPDPTIGRKSASYSSTNSSKVFCSCVPCERATGASFVICPTCQGSGEIPRELEKQLVALIPYGDQRLKPRHTKLSVFLAVFICLVTSSLIAFFLFPRTIAMQPAGLNSSTVAFEETDICLNITVFYAVANRIQEENTYKICTWLKIKVHHVLLHIQGTLTYSYLSHSEQLVFQNYEYVDCRGNTSVPHLLVPHPP", "length": 214 }, "evidence": [ { "id": "Q5EA90", "url": "https://omabrowser.org/oma/group/Q5EA90/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5BK83-1", "protein_name": "Transmembrane protein 106A", "gene_name": "Tmem106a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGKAFSQLTSQKDEDKSILPDNPAMASKAANYFSTGNRKPSHSCVPCEKAASTSFVTCPTCQGNGEIPQELEKQLVALIPYGDQRLKPRRTKLSVFLAVTICLLIFSLTIFFLYPRNIVVHPVGLNSSTVAFDETHVQLNMTNVLNITNSNFYPVTVTQLTAEVLHQTSVVGQVTSSLRLHIGPLASKQMPYEVASRILDENTYKICTWPKIRVHHILVNIQGALTCSYLTHPQQLPFESFEYVDCRENMSMPHLELPRPA", "length": 261 }, "evidence": [ { "id": "Q5EA90", "url": "https://omabrowser.org/oma/group/Q5EA90/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VC04-1", "protein_name": "Transmembrane protein 106A", "gene_name": "Tmem106a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGKAVSQLTSRKDEDKPILPDNPAMASQAANYFSTGSSKPAHSCMPYEKAASSSFVTCPTCQGNGEIPQEQEKQLVALIPYGDQRLKPRRTKLFVFLSVAICLLIFSLTIFFLYPRPIAVRPVGLNSSTVTFEDAHVQLNTTNVLNIFNSNFYPITVTQLTAEVLHQASVVGQVTSSLRLHIGPLASEQMPYEVASRILDENTYKICTWPKIRVHHILLNIQGSLTCSFLSHPQQLPFESFEYVDCRENMSLPHLELPRPA", "length": 261 }, "evidence": [ { "id": "Q5EA90", "url": "https://omabrowser.org/oma/group/Q5EA90/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96A25-1", "protein_name": "Transmembrane protein 106A", "gene_name": "TMEM106A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGKTFSQLGSWREDENKSILSSKPAIGSKAVNYSSTGSSKSFCSCVPCEGTADASFVTCPTCQGSGKIPQELEKQLVALIPYGDQRLKPKHTKLFVFLAVLICLVTSSFIVFFLFPRSVIVQPAGLNSSTVAFDEADIYLNITNILNISNGNYYPIMVTQLTLEVLHLSLVVGQVSNNLLLHIGPLASEQMFYAVATKIRDENTYKICTWLEIKVHHVLLHIQGTLTCSYLSHSEQLVFQSYEYVDCRGNASVPHQLTPHPP", "length": 262 }, "evidence": [ { "id": "Q5EA90", "url": "https://omabrowser.org/oma/group/Q5EA90/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q5EA90", "url": "https://www.uniprot.org/uniprotkb/Q5EA90" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "Q5EA90", "url": "https://www.uniprot.org/uniprotkb/Q5EA90" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "Q5EA90", "url": "https://www.uniprot.org/uniprotkb/Q5EA90" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "Q5EA90", "url": "https://www.uniprot.org/uniprotkb/Q5EA90" } ], "pmid": "" }, { "name": "macrophage activation", "id": "GO:0042116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042116", "evidence": [ { "database": "UniProtKB", "id": "Q5EA90", "url": "https://www.uniprot.org/uniprotkb/Q5EA90" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 249, "end_pos": 251, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA90-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 261, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA90-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA90" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], 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"MGFGDLKSPAGLQVLNDYLADKSYIEGYVPSQADVAVFEAVSGPPPADLCHALRWYNHIKSYEKEKASLPGVKKALGKYGPANVEDTTESGATDSKDDDDIDLFGSDDEEESEEAKRLREERLAQYESKKAKKPALVAKSSILLDVKPWDDETDMAKLEECVRSIQADGLVWGSSKLVPVGYGIKKLQIQCVVEDDKVGTDMLEEQITAFDEYVQSMDVAAFNKI", "length": 225, "header": "sp|Q5E983-1|EF1B_BOVIN Isoform 1 of Elongation factor 1-beta OS=Bos taurus OX=9913 GN=EEF1B PE=2 SV=3 CANONICAL=Q5E983-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZVE8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E983/entry#A0AAF6ZVE8-1", "sequence": { "sequence": "MQPLHKTKKQNKRHAQLLRQQRPKMPSTSSRLAVAMGFGDLKSPAGLQVLNDYLADKSYIEGYVPSQADVAVFEAVSGPPPADLCHALRWYNHIKSYEKEKASLPGVKKALGKYGPANVEDTTESGATDSKDDDDIDLFGSDDEEESEEAKRLREERLAQYESKKAKKPALVAKSSILLDVKPWDDETDMAKLEECVRSIQADGLVWGSSKLVPVGYGIKKLQIQCVVEDDKVGTDMLEEQITAFDEYVQSMDVAAFNKI", "length": 260, "header": "tr|A0AAF6ZVE8-1|EF1B_BOVIN Computationally mapped isoform of Elongation factor 1-beta OS=Bos taurus OX=9913 GN=EEF1B PE=2 SV=1 CANONICAL=Q5E983-1" }, "locus": { "chromosome": "2", "start_pos": 94493336, "end_pos": 94489353, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078391.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078391.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058501.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058501.2" } ] } }, { "isoform_ac": "Q5E983-1", "url": "https://www.uniprot.org/uniprotkb/Q5E983/entry#Q5E983-1", "sequence": { "sequence": "MGFGDLKSPAGLQVLNDYLADKSYIEGYVPSQADVAVFEAVSGPPPADLCHALRWYNHIKSYEKEKASLPGVKKALGKYGPANVEDTTESGATDSKDDDDIDLFGSDDEEESEEAKRLREERLAQYESKKAKKPALVAKSSILLDVKPWDDETDMAKLEECVRSIQADGLVWGSSKLVPVGYGIKKLQIQCVVEDDKVGTDMLEEQITAFDEYVQSMDVAAFNKI", "length": 225, "header": "sp|Q5E983-1|EF1B_BOVIN Isoform 1 of Elongation factor 1-beta OS=Bos taurus OX=9913 GN=EEF1B PE=2 SV=3 CANONICAL=Q5E983-1" }, "locus": { "chromosome": "2", "start_pos": 94493336, "end_pos": 94490466, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029304.2", "url": "https://www.ensembl.org/id/ENSBTAT00000029304.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029304.1", "url": "https://www.ensembl.org/id/ENSBTAP00000029304.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 106, "end_pos": 106, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CK2", "evidence": [ { "database": "UniProtKB", "id": "Q5E983", "url": "https://www.uniprot.org/uniprotkb/Q5E983" } ], "site_lbl": "Ser106" }, { "start_pos": 174, "end_pos": 174, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E983", "url": "https://www.uniprot.org/uniprotkb/Q5E983" } ], "site_lbl": "Ser174" }, { "start_pos": 42, "end_pos": 42, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E983", "url": "https://www.uniprot.org/uniprotkb/Q5E983" } ], "site_lbl": "Ser42" }, { "start_pos": 88, "end_pos": 88, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E983", "url": "https://www.uniprot.org/uniprotkb/Q5E983" } ], "site_lbl": "Thr88" }, { "start_pos": 8, "end_pos": 8, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E983", "url": "https://www.uniprot.org/uniprotkb/Q5E983" } ], "site_lbl": "Ser8" }, { "start_pos": 93, "end_pos": 93, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E983", "url": "https://www.uniprot.org/uniprotkb/Q5E983" } ], "site_lbl": "Thr93" }, { "start_pos": 95, "end_pos": 95, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E983", "url": "https://www.uniprot.org/uniprotkb/Q5E983" } ], "site_lbl": "Ser95" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E983", "url": "https://www.uniprot.org/uniprotkb/Q5E983" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:520875", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520875", "resource": "KEGG Pathway" }, { "id": "R-BTA-156842", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156842", "resource": "Reactome", "description": "Eukaryotic Translation Elongation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZZR6-1", "protein_name": "Elongation factor 1-beta", "gene_name": "EEF1B2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGFGDLKSAAGLRVLNDFLADKSYIEGYVPSQADIAVFEAVGAPPPAELFHALRWYNHIKSYEKQKASLPGIKKALGKYGPADVEDTTGAATDSKDDDDIDLFGSDDEEESEEAKKLREERLAQYESKKSKKPAVVAKSSILLDVKPWDDETDMAKLEECVRSIQADGLVWGSSKLVPVGYGIKKLQIQCVVEDDKVGTDMLEERITAFEDYVQSMDVAAFNKIVLI", "length": 227 }, "evidence": [ { "id": "Q5E983", "url": "https://omabrowser.org/oma/group/Q5E983/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O70251-1", "protein_name": "Elongation factor 1-beta", "gene_name": "Eef1b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGFGDLKTPAGLQVLNDYLADKSYIEGYVPSQADVAVFEAVSGPPPADLCHALRWYNHIKSYEKEKASLPGVKKSLGKYGPSSVEDTTGSGAADAKDDDDIDLFGSDDEEESEEAKKLREERLAQYESKKAKKPAVVAKSSILLDVKPWDDETDMTKLEECVRSIQADGLVWGSSKLVPVGYGIKKLQIQCVVEDDKVGTDMLEEQITAFEDYVQSMDVAAFNKI", "length": 225 }, "evidence": [ { "id": "Q5E983", "url": "https://omabrowser.org/oma/group/Q5E983/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O96827-1", "protein_name": "Probable elongation factor 1-beta", "gene_name": "eEF1beta", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAFGDVTTPQGLKELNAFLADNSYISGYTPSKADLSVFDALGKAPSADNVNVARWYRHIASFEAAERAAWSGTPLPQLAGGKPTVAAAAKPAADDDDDVDLFGSDDEEDEEAERIKQERVAAYAAKKSKKPALIAKSSVLLDVKPWDDETDMKEMENNVRTIEMDGLLWGASKLVPVGYGINKLQIMCVIEDDKVSIDLLQEKIEEFEDFVQSVDIAAFNKI", "length": 222 }, "evidence": [ { "id": "Q5E983", "url": "https://omabrowser.org/oma/group/Q5E983/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P24534-1", "protein_name": "Elongation factor 1-beta", "gene_name": "EEF1B2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGFGDLKSPAGLQVLNDYLADKSYIEGYVPSQADVAVFEAVSSPPPADLCHALRWYNHIKSYEKEKASLPGVKKALGKYGPADVEDTTGSGATDSKDDDDIDLFGSDDEEESEEAKRLREERLAQYESKKAKKPALVAKSSILLDVKPWDDETDMAKLEECVRSIQADGLVWGSSKLVPVGYGIKKLQIQCVVEDDKVGTDMLEEQITAFEDYVQSMDVAAFNKI", "length": 225 }, "evidence": [ { "id": "Q5E983", "url": "https://omabrowser.org/oma/group/Q5E983/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P32471-1", "protein_name": "Elongation factor 1-beta", "gene_name": "EFB1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MASTDFSKIETLKQLNASLADKSYIEGTAVSQADVTVFKAFQSAYPEFSRWFNHIASKADEFDSFPAASAAAAEEEEDDDVDLFGSDDEEADAEAEKLKAERIAAYNAKKAAKPAKPAAKSIVTLDVKPWDDETNLEEMVANVKAIEMEGLTWGAHQFIPIGFGIKKLQINCVVEDDKVSLDDLQQSIEEDEDHVQSTDIAAMQKL", "length": 206 }, "evidence": [ { "id": "Q5E983", "url": "https://omabrowser.org/oma/group/Q5E983/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q9GRF8-1", "protein_name": "Elongation factor 1-beta", "gene_name": "efa1B", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MPSFADLTTENGLVELNKFVSDKTYIVGFVPSSADVQAFNLVKTAPCATKYPHAARWFNTIASYSAAEQGQFEKVTETVTIAAPAAPKADDDVDLFGSDDEDDEEYERQLEERRKKAMEHKKPKETVIAKSSILLDVKPWDDETDMVELEKCVRSIEMDGLVWGASKLVAVGYGIKKLVINLVVEDLKVSTDELEEKIKDFEDYVQSVDVAAFNKI", "length": 216 }, "evidence": [ { "id": "Q5E983", "url": "https://omabrowser.org/oma/group/Q5E983/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9SCX3-1", "protein_name": "Elongation factor 1-beta 2", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAVTFSDLHTEEGVKSVEEHLAGKTYISGDQLSVDDVKVYAAVPVKPSDAFPNASKWYESVASQLAKSFPGKAVGVQFGGSAAAAPAVEAEAPAAAADDDDDMDLFGDETEEEKKAAEEREAAKKDTKKPKESGKSSVLMDVKPWDDETDMKKLEEAVRGVEMPGLFWGASKLVPVGYGIKKLTIMFTIVDDLVSPDNLIEDFLTSEPNNEYIQSCDIVAFNKI", "length": 224 }, "evidence": [ { "id": "Q5E983", "url": "https://omabrowser.org/oma/group/Q5E983/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5E983", "url": "https://www.uniprot.org/uniprotkb/Q5E983" } ], "pmid": "" }, { "name": "eukaryotic translation elongation factor 1 complex", "id": "GO:0005853", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005853", "evidence": [ { "database": "UniProtKB", "id": "Q5E983", "url": "https://www.uniprot.org/uniprotkb/Q5E983" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q5E983", "url": "https://www.uniprot.org/uniprotkb/Q5E983" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "Q5E983", "url": "https://www.uniprot.org/uniprotkb/Q5E983" } ], "pmid": "" }, { "name": "translation elongation factor activity", "id": "GO:0003746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003746", "evidence": [ { "database": "UniProtKB", "id": "Q5E983", "url": "https://www.uniprot.org/uniprotkb/Q5E983" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translational elongation", "id": "GO:0006414", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006414", "evidence": [ { "database": "UniProtKB", "id": "Q5E983", "url": "https://www.uniprot.org/uniprotkb/Q5E983" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E983-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 225, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E983-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E983" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 8, 42, 88, 93, 95, 106, 174 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9Q3-1", "uniprot_ac": "Q5E9Q3", "uniprot_id": "MITOK_BOVIN", "mass": { "chemical_mass": 44985.0, "monoisotopic_mass": 44985.0 }, "refseq": { "ac": "NP_001015619", "name": "mitochondrial potassium channel", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015619" }, "gene_names": [ { "name": "CCDC51", "type": "recommended", "evidence": [ { "id": "Q5E9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3" } ] }, { "name": "CCDC51", "type": "synonym", "evidence": [ { "id": "NP_001015619", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015619" } ] }, { "name": "MITOK", "type": "synonym", "evidence": [ { "id": "NP_001015619", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015619" } ] }, { "name": "Mitok", "type": "synonym", "evidence": [ { "id": "Q5E9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3" } ] } ], "protein_names": [ { "name": "Mitochondrial potassium channel", "type": "recommended", "evidence": [ { "id": "Q5E9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3/entry#names_and_taxonomy" } ] }, { "name": "Coiled-coil domain-containing protein 51", "type": "synonym", "evidence": [ { "id": "Q5E9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3/entry#names_and_taxonomy" } ] }, { "name": "MITOK", "type": "synonym", "evidence": [ { "id": "Q5E9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain-containing protein 51", "type": "synonym", "evidence": [ { "id": "NP_001015619", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015619" } ] }, { "name": "mitochondrial potassium channel", "type": "synonym", "evidence": [ { "id": "NP_001015619", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015619" } ] } ], "function": [ { "annotation": "Pore-forming subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). Together with ATP-binding subunit ABCB8/MITOSUR of the mitoK(ATP) channel, mediates ATP-dependent K(+) currents across the mitochondrial inner membrane. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix. May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q3", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3#function" }, { "database": "UniProtKB", "id": "Q3URS9", "url": "https://www.uniprot.org/uniprotkb/Q3URS9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q3", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC51", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3", "locus": { "chromosome": "22", "start_pos": 51432980, "end_pos": 51423704, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013413", "url": "https://www.ensembl.org/id/ENSBTAG00000013413" } ] } } ], "crossref": [ { "id": "Q5E9Q3", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9Q3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013413", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013413", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "517515", "url": "https://www.ncbi.nlm.nih.gov/gene/517515", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR037660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517515", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517515", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "STATTWW", "url": "https://omabrowser.org/oma/group/STATTWW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9Q3", "url": "https://www.orthodb.org/?gene=Q5E9Q3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28624", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28624", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28624:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28624:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001015619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015619", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29463", "url": "https://www.rhea-db.org/rhea/29463", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6ZWN5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZWN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZWN5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9Q3", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9Q3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTGRSRVLAMRHVGGVSPVLVRRDLFLTRTLCSHGPSQPREKRPEEVALGLYHRLTALGAALGHSIRQRASSTAKTWWDRYEEFVGLNEVREAQGNVTEAEKVFMVARGLVREAREDLESQQTKLKEVRDRLDRISRDDNQYLELATLEHRMLQEEKRLRMTYLRAEDSEREKFSLFSAAVRESHEKERTRAERTKNWSLIGSVLGALIGVAGSTYVNRVRLQELKALLLEAQKGPVSLQEAIREQASSYSLQQRDLRDLVADLKGLVQAGTGQGSLSQAGSSPTQDRDTDVLSAALREQLSHSRQVRSRLEGLREQLDGLEKTVSQVAGVVQLAKAAAHPGLESADGALPGSLLEQGSMIMALSDTEQRLEAQVNRNTVYGTLVTCATFVAVLPVLYMLFRAS", "length": 404, "header": "sp|Q5E9Q3-1|MITOK_BOVIN Isoform 1 of Mitochondrial potassium channel OS=Bos taurus OX=9913 GN=CCDC51 PE=2 SV=1 CANONICAL=Q5E9Q3-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZWN5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3/entry#A0AAF6ZWN5-1", "sequence": { "sequence": "MNKTVPALAERPFCHGPSQPREKRPEEVALGLYHRLTALGAALGHSIRQRASSTAKTWWDRYEEFVGLNEVREAQGNVTEAEKVFMVARGLVREAREDLESQQTKLKEVRDRLDRISRDDNQYLELATLEHRMLQEEKRLRMTYLRAEDSEREKFSLFSAAVRESHEKERTRAERTKNWSLIGSVLGALIGVAGSTYVNRVRLQELKALLLEAQKGPVSLQEAIREQASSYSLQQRDLRDLVADLKGLVQAGTGQGSLSQAGSSPTQDRDTDVLSAALREQLSHSRQVRSRLEGLREQLDGLEKTVSQVAGVVQLAKAAAHPGLESADGALPGSLLEQGSMIMALSDTEQRLEAQVNRNTVYGTLVTCATFVAVLPVLYMLFRAS", "length": 385, "header": "tr|A0AAF6ZWN5-1|MITOK_BOVIN Computationally mapped isoform of Mitochondrial potassium channel OS=Bos taurus OX=9913 GN=CCDC51 PE=2 SV=1 CANONICAL=Q5E9Q3-1" }, "locus": { "chromosome": "22", "start_pos": 51432746, "end_pos": 51429841, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069946.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069946.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058493.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058493.2" } ] } }, { "isoform_ac": "Q5E9Q3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3/entry#Q5E9Q3-1", "sequence": { "sequence": "MTGRSRVLAMRHVGGVSPVLVRRDLFLTRTLCSHGPSQPREKRPEEVALGLYHRLTALGAALGHSIRQRASSTAKTWWDRYEEFVGLNEVREAQGNVTEAEKVFMVARGLVREAREDLESQQTKLKEVRDRLDRISRDDNQYLELATLEHRMLQEEKRLRMTYLRAEDSEREKFSLFSAAVRESHEKERTRAERTKNWSLIGSVLGALIGVAGSTYVNRVRLQELKALLLEAQKGPVSLQEAIREQASSYSLQQRDLRDLVADLKGLVQAGTGQGSLSQAGSSPTQDRDTDVLSAALREQLSHSRQVRSRLEGLREQLDGLEKTVSQVAGVVQLAKAAAHPGLESADGALPGSLLEQGSMIMALSDTEQRLEAQVNRNTVYGTLVTCATFVAVLPVLYMLFRAS", "length": 404, "header": "sp|Q5E9Q3-1|MITOK_BOVIN Isoform 1 of Mitochondrial potassium channel OS=Bos taurus OX=9913 GN=CCDC51 PE=2 SV=1 CANONICAL=Q5E9Q3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 65, "end_pos": 65, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q3", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3" } ], "site_lbl": "Ser65" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q3", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:517515", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517515", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZJG3-1", "protein_name": "Coiled-coil domain containing 51", "gene_name": "CCDC51", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGPMKYKSSVSSVSCGLQYHHALIKQSQKMNVHLVRTYCAPGPKRPEGKSAIETAVGILNRVAEAGAVVGKNSLQKISATGKNWWDKYEEFVGLNEVREAQGKVTEAENVFMIARGIVRQARENVEAQQIKLKEVRDRLDRVSRDDTQYLELATLEHRLLQEEKRYRAAYLNAEESEREKFSLFSAAVRESHEKERTRAEKTKNWSIIGSVLGAIIGVLGSTYVNRVRLQELKVLVLEAQKAPINLQEAIKEQASTYDLQQKDLSDVIADLKNILQTKTSQGTKEGVSLAREDRSDSIKIDSLLIPLKEQLNYTKQVSSCLGSLQQQFTRLQESVAQIISEVQSVKLAVHSRPMDRVTARSSGESKGQASAVRDVILELCDTERRLESQIKRNSIYSTALTCTVFAVSLPVLYILLKGN", "length": 419 }, "evidence": [ { "id": "Q5E9Q3", "url": "https://omabrowser.org/oma/group/Q5E9Q3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1QRW6-1", "protein_name": "Mitochondrial potassium channel", "gene_name": "ccdc51", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRFRTNTVFPGSFVSTCLYRHQGFNPVQWSLHRSYCTQQQSPKDEPNKTTSAKERTASALAYAGELGKQWGRNAVKTTSVTVNYWWERYEEFVGLNEVRDAQSKVTEAEKAFMVARGIVREAHTSLEALQVRLKEVRDRLDRVSREEAHYLELATLEHKLLQEERRLRTSHENAEEAEREKFALFSAAVRESHDKERTRAERTKNWSIIGSVLGAIIGVMGSTYINRVRLQELKSLLLEAQKGPVSLQEAIKVQASLHKTQQDELSNLIHSLRTTLKGSGEDAKIGKPAIVQPAAAVVQSSTSGASEEAIQEILQNSQKAQGLIESLKPQLEQVWESLSKVGTELQTVKTTLQSRPLEKPVIQTRGTQLFVCDTETVVQGLGQTEKRLEAQINKTSLYNTVLTCAAFAVTVPVLYVLLRGT", "length": 421 }, "evidence": [ { "id": "Q5E9Q3", "url": "https://omabrowser.org/oma/group/Q5E9Q3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q3URS9-1", "protein_name": "Mitochondrial potassium channel", "gene_name": "Ccdc51", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTGCSPVFAMQHVVGVPRILVRRTFLGTDVTMTRTLCSPGPREKRPEAAALGLFHRLPELGRTLSHTVRHQAASTAKAWWDRYEEFVGLNEVREAQGNVTEAEKVFMVARGLVREAREGLEAQQTKLKEVRDRLDRVSREDNQYLELATLEHRMLQEEKRLRIAYLRAEDSEREKFSLFSAAVRESHEKERTRAERTKNWSLIGSVLGALIGVAGSTYVNRVRLQELKALLLEAQKGPASLQEAIREQASSYSLQQKDLQDLMMDLRGLVHAEQGQGSGSPTGSSTRGKDIDGLSATMKEQLRHSRQVYSCLEGLREQLDGLEKTCSQMAGVLQLAQAPAHPGTVGPVDGALPSSLLEHGSVILALSEMEQRLEAQANRNTVSSTLVTCVTFLATLPLLYMLFKTS", "length": 406 }, "evidence": [ { "id": "Q5E9Q3", "url": "https://omabrowser.org/oma/group/Q5E9Q3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5PPN7-1", "protein_name": "Mitochondrial potassium channel", "gene_name": "Ccdc51", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTGCSPVFTMQQVVGVSHRLVWRTFRGTDLLMTRTLCSPGPSRPGEKRPEAAALGLYHRLPELGRTLSHTIRNQAASTAKAWWDRYEEFVGLNEVREAQGNVTEAEKVFMVARGLVREAREDLEAQQTKLKEVRDRLDRVSREDNQYLELATLEHRMLQEEKRLRIAYLRAEDSEREKFSLFSAAVRESHEKERTRAERTKNWSLIGSVLGALIGVAGSTYVNRVRLQELKALLLEAQKGPVSLQEAIREQASSYSLQQKDLQNLMVDLRGLVHVGQDQGSGSPTGPSSPRGKDIDGLSAAMKEQLNHSRQVYSCLEGLREQLDSLEKTCSQMAGVVRLAKVPAHPGMVEPLDGALPSSLLEHGSTMLALSEMEQRLEAQANRNAISSTLVTCVTFMATLPLLYMLFKTS", "length": 410 }, "evidence": [ { "id": "Q5E9Q3", "url": "https://omabrowser.org/oma/group/Q5E9Q3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96ER9-1", "protein_name": "Mitochondrial potassium channel", "gene_name": "CCDC51", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMGRSPGFAMQHIVGVPHVLVRRGLLGRDLFMTRTLCSPGPSQPGEKRPEEVALGLHHRLPALGRALGHSIQQRATSTAKTWWDRYEEFVGLNEVREAQGKVTEAEKVFMVARGLVREAREDLEVHQAKLKEVRDRLDRVSREDSQYLELATLEHRMLQEEKRLRTAYLRAEDSEREKFSLFSAAVRESHEKERTRAERTKNWSLIGSVLGALIGVAGSTYVNRVRLQELKALLLEAQKGPVSLQEAIREQASSYSRQQRDLHNLMVDLRGLVHAAGPGQDSGSQAGSPPTRDRDVDVLSAALKEQLSHSRQVHSCLEGLREQLDGLEKTCSQMAGVVQLVKSAAHPGLVEPADGAMPSFLLEQGSMILALSDTEQRLEAQVNRNTIYSTLVTCVTFVATLPVLYMLFKAS", "length": 411 }, "evidence": [ { "id": "Q5E9Q3", "url": "https://omabrowser.org/oma/group/Q5E9Q3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q3", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q3", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3" } ], "pmid": "" }, { "name": "mitochondrial ATP-gated potassium channel complex", "id": "GO:0062157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062157", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q3", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell volume homeostasis", "id": "GO:0006884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006884", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q3", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3" } ], "pmid": "" }, { "name": "potassium ion transmembrane transport", "id": "GO:0071805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q3", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3" } ], "pmid": "" }, { "name": "mitochondrial potassium ion transmembrane transport", "id": "GO:0140141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140141", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q3", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "mitochondrial ATP-gated potassium channel activity", "id": "GO:0062156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062156", "evidence": [ { "database": "UniProtKB", "id": "Q5E9Q3", "url": "https://www.uniprot.org/uniprotkb/Q5E9Q3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 197, "end_pos": 199, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29463", "name": "", "equation": "K(+)(in) = K(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35526-1" ], "evidence": [ { "id": "29463", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29463" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P35526", "gene_name": "CLIC5", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "P35526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35526" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9Q3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 404, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9Q3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9Q3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 65 ], "sequon_annotation_sites": [ { "start_pos": 197, "end_pos": 199 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58D45-1", "uniprot_ac": "Q58D45", "uniprot_id": "CDIP1_BOVIN", "mass": { "chemical_mass": 21864.0, "monoisotopic_mass": 21864.0 }, "refseq": { "ac": "NP_001014892", "name": "cell death-inducing p53-target protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014892" }, "gene_names": [ { "name": "CDIP1", "type": "recommended", "evidence": [ { "id": "Q58D45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D45" } ] }, { "name": "C16orf5", "type": "synonym", "evidence": [ { "id": "NP_001014892", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014892" } ] }, { "name": "C25H16orf5", "type": "synonym", "evidence": [ { "id": "NP_001014892", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014892" } ] }, { "name": "CDIP1", "type": "synonym", "evidence": [ { "id": "NP_001014892", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014892" } ] } ], "protein_names": [ { "name": "Cell death-inducing p53-target protein 1", "type": "recommended", "evidence": [ { "id": "Q58D45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D45/entry#names_and_taxonomy" } ] }, { "name": "LITAF-like protein", "type": "synonym", "evidence": [ { "id": "NP_001014892", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014892" }, { "id": "Q58D45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D45/entry#names_and_taxonomy" } ] }, { "name": "cell death-inducing p53-target protein 1", "type": "synonym", "evidence": [ { "id": "NP_001014892", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014892" } ] } ], "function": [ { "annotation": "Acts as an important p53/TP53-apoptotic effector. Regulates TNF-mediated apoptosis in a p53/TP53-dependent manner.", "evidence": [ { "database": "UniProtKB", "id": "Q58D45", "url": "https://www.uniprot.org/uniprotkb/Q58D45#function" }, { "database": "UniProtKB", "id": "Q9H305", "url": "https://www.uniprot.org/uniprotkb/Q9H305#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58D45", "url": "https://www.uniprot.org/uniprotkb/Q58D45" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDIP1", "url": "https://www.uniprot.org/uniprotkb/Q58D45", "locus": { "chromosome": "25", "start_pos": 3654953, "end_pos": 3679061, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018938", "url": "https://www.ensembl.org/id/ENSBTAG00000018938" } ] } } ], "crossref": [ { "id": "Q58D45", "url": "https://alphafold.ebi.ac.uk/entry/Q58D45", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018938", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018938", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510242", "url": "https://www.ncbi.nlm.nih.gov/gene/510242", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006629", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006629", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510242", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510242", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YTYKRVC", "url": "https://omabrowser.org/oma/group/YTYKRVC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58D45", "url": "https://www.orthodb.org/?gene=Q58D45", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23292", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23292", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23292:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23292:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10601", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10601", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014892", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAF6ZZT0", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZZT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZZT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZZT0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D45", "url": "https://www.uniprot.org/uniprotkb/Q58D45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D45-1", "url": "https://www.uniprot.org/uniprotkb/Q58D45-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D45-2", "url": "https://www.uniprot.org/uniprotkb/Q58D45-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSNDPPPPYPGGPTAPLLEEKSGAPPTPGRTSPAVMQPPPGMSLPPADIGPPPYEPPGHPMPQPGFIPPHVNADGTYMPSGFYPPPGPHPPMGYYPPGPYPPGPYAGPGGHTATVLVPSGAATTVTVLQGEIFEGAPVQTVCPHCQQAITTKISYEIGLMNFVLGFFCCFMGCDLGCCLIPCLINDFKDVTHTCPSCKAYIYTYKRLC", "length": 208, "header": "sp|Q58D45-1|CDIP1_BOVIN Isoform 1 of Cell death-inducing p53-target protein 1 OS=Bos taurus OX=9913 GN=CDIP1 PE=2 SV=1 CANONICAL=Q58D45-1" }, "isoforms": [ { "isoform_ac": "A0AAF6ZZT0-1", "url": "https://www.uniprot.org/uniprotkb/Q58D45/entry#A0AAF6ZZT0-1", "sequence": { "sequence": "MPFTAAGSCTWSRAPPTTKPLRFLPRPPPHPGRTSPAVMQPPPGMSLPPADIGPPPYEPPGHPMPQPGFIPPHVNADGTYMPSGFYPPPGPHPPMGYYPPGPYPPGPYAGPGGHTATVLVPSGAATTVTVLQGEIFEGAPVQTVCPHCQQAITTKISYEIGLMNFVLGFFCCFMGCDLGCCLIPCLINDFKDVTHTCPSCKAYIYTYKRLC", "length": 211, "header": "tr|A0AAF6ZZT0-1|CDIP1_BOVIN Computationally mapped isoform of Cell death-inducing p53-target protein 1 OS=Bos taurus OX=9913 GN=CDIP1 PE=2 SV=1 CANONICAL=Q58D45-1" }, "locus": { "chromosome": "25", "start_pos": 3657257, "end_pos": 3656178, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079049.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079049.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060751.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060751.2" } ] } }, { "isoform_ac": "Q58D45-1", "url": "https://www.uniprot.org/uniprotkb/Q58D45/entry#Q58D45-1", "sequence": { "sequence": "MSNDPPPPYPGGPTAPLLEEKSGAPPTPGRTSPAVMQPPPGMSLPPADIGPPPYEPPGHPMPQPGFIPPHVNADGTYMPSGFYPPPGPHPPMGYYPPGPYPPGPYAGPGGHTATVLVPSGAATTVTVLQGEIFEGAPVQTVCPHCQQAITTKISYEIGLMNFVLGFFCCFMGCDLGCCLIPCLINDFKDVTHTCPSCKAYIYTYKRLC", "length": 208, "header": "sp|Q58D45-1|CDIP1_BOVIN Isoform 1 of Cell death-inducing p53-target protein 1 OS=Bos taurus OX=9913 GN=CDIP1 PE=2 SV=1 CANONICAL=Q58D45-1" }, "locus": { "chromosome": "25", "start_pos": 3657352, "end_pos": 3656178, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037513.6", "url": "https://www.ensembl.org/id/ENSBTAT00000037513.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037343.6", "url": "https://www.ensembl.org/id/ENSBTAP00000037343.6" } ] } }, { "isoform_ac": "Q58D45-2", "url": "https://www.uniprot.org/uniprotkb/Q58D45/entry#Q58D45-2", "sequence": { "sequence": "MSNDPPPPYPGGPTAPLLEEKSGAPPTPGRTSPAVMQPPPGMSLPPADIGPPPYEPPGHPMPQPGFIPPHVNADGTYMPSGFYPPPGPHPPMGYYPPGPYPPGPYAGPGGHTATVLVPSGAATTVTVLQGEIFEGAPVQTVCPHCQQAITTKISYEIGLMNFVLGFFCCFMGPPSLLMQV", "length": 180, "header": "sp|Q58D45-2|CDIP1_BOVIN Isoform 2 of Cell death-inducing p53-target protein 1 OS=Bos taurus OX=9913 GN=CDIP1 PE=2 SV=1 CANONICAL=Q58D45-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 14, "start_aa": "Thr", "end_pos": 14, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr14", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 27, "start_aa": "Thr", "end_pos": 27, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr27", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58D45", "url": "https://www.uniprot.org/uniprotkb/Q58D45" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:510242", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510242", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YZD4-1", "protein_name": "Cell death-inducing p53-target protein 1", "gene_name": "CDIP1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSNDPPPPYPGGPSAPPIEEKHGPPPATGTAGPGCQRGAAAERAGAGGALPADVREFGLLVAQGMNLWARCLGAVPDGHFPVPSVLSPQSLPVCFIPLPRSPSFSCCVLFPWRGSGSLSRAITICCLLSWLLTLCFLSDGISPAMVQPQGAPIPPPEFGPPPYEPPQPGFVPPHMPTDGSGPYVPPGYYPPPGPHPPMGYYPAPGHYPSPSGHTATVLVPSGTATTVTVLQGEIFQGAPVQTVCPHCQQAITTKISYEIGLMSFLLGFFCCFVGCDLCCCLIPCLFDDFKDVTHTCPNCKAYIYTYKRMC", "length": 310 }, "evidence": [ { "id": "Q58D45", "url": "https://omabrowser.org/oma/group/Q58D45/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HS66-1", "protein_name": "Cell death-inducing p53-target protein 1", "gene_name": "Cdip1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSNEPPPPYPGGPTAPLLEEKSGAPPTPGRASPAVMQPPPGMPLPSADIAPPPYEPPGHPVPQPGFVPPHMSADGAYMPAGFYPPPGPHPPMGYYPPGPYPPGPYPGPGGHTATVLVPSGAATTVTVLQGEIFEGAPVQTVCPHCQQAITTKISYEIGLMNFVLGFFCCFMGCDLGCCLIPCLINDFKDVTHTCPSCKAYIYTYKRLC", "length": 208 }, "evidence": [ { "id": "Q58D45", "url": "https://omabrowser.org/oma/group/Q58D45/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q54HX8-1", "protein_name": "Cell death-inducing p53-target protein 1 homolog", "gene_name": "litaf", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGQDNINLNKVDGQPSSPPQEQQQQQQYPPQGYPQQQQYPPQQGYPPQQYPPQQGYPPQQYPPQQGYPQQQPPQQYPAPVGAPQQPYMATQQVVVQQVYVQPTFGVVPVDCICQHCQTRMSTKTSYKSGSMVWLVCVLLIIFGCWLGCCLIPFGIDSLKDVQHKCSHCKKVLYRFDRMSGK", "length": 181 }, "evidence": [ { "id": "Q58D45", "url": "https://omabrowser.org/oma/group/Q58D45/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5U2U6-1", "protein_name": "Cell death-inducing p53-target protein 1", "gene_name": "Cdip1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSNEPPPPYPGGPTAPLLEEKSGAPHTPGRTSPAVMQPPPGMPLPSADIAPPPYEPPGHPVPQPGFVPPHMNADGTYMPAGFYPPPGPHPPMGYYPPGPYPPGSYPGPGGHTATVLVPSGAATTVTVLQGEIFEGAPVQTVCPHCQQAITTKISYEIGLMNFVLGFFCCFMGCDLGCCLIPCLINDFKDVTHTCPSCKAYICTYKRLC", "length": 208 }, "evidence": [ { "id": "Q58D45", "url": "https://omabrowser.org/oma/group/Q58D45/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9DB75-1", "protein_name": "Cell death-inducing p53-target protein 1", "gene_name": "Cdip1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSNEPPPPYPGGPTAPLLEEKSGAPLTPGRTSPAVMQPPPGMPLPSADIAPPPYEPPGQPVPQPGFVPPHMNADGTYMPAGFYPPPGPHPPMGYYPPGPYPPGPYPGPGGHTATVLVPSGAATTVTVLQGEIFEGAPVQTVCPHCQQAITTKISYEIGLMNFVLGFFCCFMGCDLGCCLIPCLINDFKDVTHTCPSCKAYICTYKRLC", "length": 208 }, "evidence": [ { "id": "Q58D45", "url": "https://omabrowser.org/oma/group/Q58D45/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H305-1", "protein_name": "Cell death-inducing p53-target protein 1", "gene_name": "CDIP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSEPPPPYPGGPTAPLLEEKSGAPPTPGRSSPAVMQPPPGMPLPPADIGPPPYEPPGHPMPQPGFIPPHMSADGTYMPPGFYPPPGPHPPMGYYPPGPYTPGPYPGPGGHTATVLVPSGAATTVTVLQGEIFEGAPVQTVCPHCQQAITTKISYEIGLMNFVLGFFCCFMGCDLGCCLIPCLINDFKDVTHTCPSCKAYIYTYKRLC", "length": 208 }, "evidence": [ { "id": "Q58D45", "url": "https://omabrowser.org/oma/group/Q58D45/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q58D45", "url": "https://www.uniprot.org/uniprotkb/Q58D45" } ], "pmid": "" }, { "name": "cytoplasmic side of lysosomal membrane", "id": "GO:0098574", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098574", "evidence": [ { "database": "UniProtKB", "id": "Q58D45", "url": "https://www.uniprot.org/uniprotkb/Q58D45" } ], "pmid": "" }, { "name": "cytoplasmic side of late endosome membrane", "id": "GO:0098560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098560", "evidence": [ { "database": "UniProtKB", "id": "Q58D45", "url": "https://www.uniprot.org/uniprotkb/Q58D45" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q58D45", "url": "https://www.uniprot.org/uniprotkb/Q58D45" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "Q58D45", "url": "https://www.uniprot.org/uniprotkb/Q58D45" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q58D45", "url": "https://www.uniprot.org/uniprotkb/Q58D45" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q58D45", "url": "https://www.uniprot.org/uniprotkb/Q58D45" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "id": "GO:0042771", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042771", "evidence": [ { "database": "UniProtKB", "id": "Q58D45", "url": "https://www.uniprot.org/uniprotkb/Q58D45" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q58D45", "url": "https://www.uniprot.org/uniprotkb/Q58D45" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58D45-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 208, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58D45-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58D45" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58D45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D45" }, { "id": "PRU01181", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01181" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LITAF", "eco_id": "ECO_0000255", "start_pos": 122, "end_pos": 206, "start_aa": "Ala", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "Q58D45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D45#function" }, { "id": "Q58D45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D45" } ], "binding_site_uniprot": 142, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 142, "end_pos": 142, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58D45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D45#function" }, { "id": "Q58D45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D45" } ], "binding_site_uniprot": 145, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 145, "end_pos": 145, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58D45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D45#function" }, { "id": "Q58D45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D45" } ], "binding_site_uniprot": 194, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 194, "end_pos": 194, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58D45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D45#function" }, { "id": "Q58D45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D45" } ], "binding_site_uniprot": 197, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 197, "end_pos": 197, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 14, 27 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBJ3-1", "uniprot_ac": "Q3ZBJ3", "uniprot_id": "FXYD7_BOVIN", "mass": { "chemical_mass": 8352.0, "monoisotopic_mass": 8352.0 }, "refseq": { "ac": "NP_001032716", "name": "FXYD domain-containing ion transport regulator 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032716" }, "gene_names": [ { "name": "FXYD7", "type": "recommended", "evidence": [ { "id": "Q3ZBJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ3" } ] }, { "name": "FXYD7", "type": "synonym", "evidence": [ { "id": "NP_001032716", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032716" } ] } ], "protein_names": [ { "name": "FXYD domain-containing ion transport regulator 7", "type": "recommended", "evidence": [ { "id": "Q3ZBJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ3/entry#names_and_taxonomy" } ] }, { "name": "FXYD domain-containing ion transport regulator 7", "type": "synonym", "evidence": [ { "id": "NP_001032716", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032716" } ] } ], "function": [ { "annotation": "Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (By similarity). Reduces the apparent affinity for external K(+), an effect that depends on the presence of external Na(+) and voltage (By similarity). Increases the apparent affinity for intracellular Na(+) (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBJ3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ3#function" }, { "database": "UniProtKB", "id": "P59648", "url": "https://www.uniprot.org/uniprotkb/P59648#function" }, { "database": "UniProtKB", "id": "P58549", "url": "https://www.uniprot.org/uniprotkb/P58549#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBJ3", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FXYD7", "url": "https://www.uniprot.org/uniprotkb/Q3ZBJ3", "locus": { "chromosome": "18", "start_pos": 45877888, "end_pos": 45868746, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": 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kinase S-type, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001029828", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029828" } ] }, { "name": "creatine kinase, mitochondrial 2 (sarcomeric)", "type": "synonym", "evidence": [ { "id": "NP_001029828", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029828" } ] }, { "name": "mib-CK", "type": "synonym", "evidence": [ { "id": "NP_001029828", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029828" } ] }, { "name": "sarcomeric mitochondrial creatine kinase", "type": "synonym", "evidence": [ { "id": "NP_001029828", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029828" } ] } ], "function": [ { "annotation": "Data show that mtCK-cardiolipin domains were observed not only with unsaturated cardiolipins, but also with the cardiolipin precursor phosphatidylglycerol.", "evidence": [ { "database": "RefSeq", "id": "NP_001029828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029828" }, { "database": "PubMed", "id": "21256109", "url": "https://glygen.org/publication/PubMed/21256109" } ] }, { "annotation": "Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CKMT2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1", "locus": { "chromosome": "7", "start_pos": 81274992, "end_pos": 81249468, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001003", "url": "https://www.ensembl.org/id/ENSBTAG00000001003" } ] } } ], "crossref": [ { "id": "Q3ZBP1", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBP1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00716", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00716", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538944", "url": "https://www.ncbi.nlm.nih.gov/gene/538944", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q3ZBP1", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q3ZBP1*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000749", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000749", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014746", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014746", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022414", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022414", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022415", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022415", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036802", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036802", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538944", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538944", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3ZBP1", "url": "https://www.orthodb.org/?gene=Q3ZBP1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11547", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11547", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11547:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11547:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00217", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00217", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02807", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02807", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029828", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17157", "url": "https://www.rhea-db.org/rhea/17157", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3ZBP1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBP1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASTFSKLLTGRNASLLFATLGTGALTTGYLLNKQNVCAAAREQHKLFPPSADYPDLRKHNNCMAECLTPAIYAKLRNKVTPSGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVMKHPTDLDASKITQGQFDERYVLSSRVRTGRSIRGLSLPPACSRAELREVENVAITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCAGMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKDPRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGKK", "length": 419, "header": "sp|Q3ZBP1-1|KCRS_BOVIN Isoform 1 of Creatine kinase S-type, mitochondrial OS=Bos taurus OX=9913 GN=CKMT2 PE=2 SV=1 CANONICAL=Q3ZBP1-1" }, "isoforms": [ { "isoform_ac": "Q3ZBP1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1/entry#Q3ZBP1-1", "sequence": { "sequence": "MASTFSKLLTGRNASLLFATLGTGALTTGYLLNKQNVCAAAREQHKLFPPSADYPDLRKHNNCMAECLTPAIYAKLRNKVTPSGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVMKHPTDLDASKITQGQFDERYVLSSRVRTGRSIRGLSLPPACSRAELREVENVAITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCAGMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKDPRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGKK", "length": 419, "header": "sp|Q3ZBP1-1|KCRS_BOVIN Isoform 1 of Creatine kinase S-type, mitochondrial OS=Bos taurus OX=9913 GN=CKMT2 PE=2 SV=1 CANONICAL=Q3ZBP1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 255, "end_pos": 255, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1" } ], "site_lbl": "Tyr255" }, { "start_pos": 356, "end_pos": 356, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1" } ], "site_lbl": "Thr356" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Acyl chain composition determines cardiolipin clustering induced by mitochondrial creatine kinase binding to monolayers.", "journal": "Biochimica et biophysica acta", "date": "2011-04", "authors": "Maniti Ofelia, Cheniour Mouhedine, Lecompte Marie-France, Marcillat Olivier, Buchet Ren\u00e9, Vial Christian, Granjon Thierry", "evidence": [ { "database": "RefSeq", "id": "NP_001029828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029828" } ], "reference": [ { "type": "PubMed", "id": "21256109", "url": "https://glygen.org/publication/PubMed/21256109" } ] } ], "pathway": [ { "id": "bta:538944", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538944", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "phosphocreatine biosynthetic process", "id": "GO:0046314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046314", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "creatine kinase activity", "id": "GO:0004111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004111", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 13, "end_pos": 15, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17157", "name": "", "equation": "creatine + ATP = N-phosphocreatine + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZIA4-1", "Q5EA61-1", "Q9TTK8-1", "Q9XSC6-1", "Q3ZBP1-1" ], "evidence": [ { "id": "17157", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6ZIA4", "gene_name": "CKB", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "A0AAF6ZIA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "A0AAF6ZIA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4" } ] } ] }, { "uniprot_ac": "Q3ZBP1", "gene_name": "CKMT2", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "Q3ZBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "Q3ZBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1" } ] } ] }, { "uniprot_ac": "Q5EA61", "gene_name": "CKB", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "Q5EA61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA61" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "Q5EA61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA61" } ] } ] }, { "uniprot_ac": "Q9TTK8", "gene_name": "CKMT1", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ] } ] }, { "uniprot_ac": "Q9XSC6", "gene_name": "CKM", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "Q9XSC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "Q9XSC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBP1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 419, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBP1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBP1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1" }, { "id": "PRU00843", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00843" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phosphagen kinase C-terminal", "eco_id": "ECO_0000255", "start_pos": 159, "end_pos": 401, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q3ZBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1" }, { "id": "PRU00842", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phosphagen kinase N-terminal", "eco_id": "ECO_0000255", "start_pos": 46, "end_pos": 132, "start_aa": "Lys", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.3.2", "ec_name": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "2.7.3.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2" }, { "id": "2.7.3.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.3.2" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 255, 356 ], "sequon_annotation_sites": [ { "start_pos": 13, "end_pos": 15 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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}, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBP4-1", "uniprot_ac": "Q3ZBP4", "uniprot_id": "RCAN1_BOVIN", "mass": { "chemical_mass": 22691.0, "monoisotopic_mass": 22691.0 }, "refseq": { "ac": "NP_001029851", "name": "calcipressin-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029851" }, "gene_names": [ { "name": "RCAN1", "type": "recommended", "evidence": [ { "id": "Q3ZBP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP4" } ] }, { "name": "DSCR1", "type": "synonym", "evidence": [ { "id": "NP_001029851", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029851" }, { "id": "Q3ZBP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP4" } ] }, { "name": "RCAN1", "type": "synonym", "evidence": [ { "id": "NP_001029851", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029851" } ] } ], "protein_names": [ { "name": "Calcipressin-1", "type": "recommended", "evidence": [ { "id": "Q3ZBP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP4/entry#names_and_taxonomy" } ] }, { "name": "Down syndrome critical region protein 1", "type": "synonym", "evidence": [ { "id": "Q3ZBP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP4/entry#names_and_taxonomy" } ] }, { "name": "Regulator of calcineurin 1", "type": "synonym", "evidence": [ { "id": "Q3ZBP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP4/entry#names_and_taxonomy" } ] }, { "name": "calcipressin-1", "type": "synonym", "evidence": [ { "id": "NP_001029851", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029851" } ] }, { "name": "down syndrome critical region protein 1", "type": "synonym", "evidence": [ { "id": "NP_001029851", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029851" } ] } ], "function": [ { "annotation": "Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP4#function" }, { "database": "UniProtKB", "id": "Q9JHG6", "url": "https://www.uniprot.org/uniprotkb/Q9JHG6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RCAN1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP4", "locus": { "chromosome": "1", "start_pos": 1002223, "end_pos": 991023, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020035", "url": "https://www.ensembl.org/id/ENSBTAG00000020035" } ] } } ], "crossref": [ { "id": "Q3ZBP4", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBP4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020035", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020035", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12708", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12708", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539640", "url": "https://www.ncbi.nlm.nih.gov/gene/539640", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006931", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006931", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034906", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034906", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539640", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539640", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RIMQTRC", "url": "https://omabrowser.org/oma/group/RIMQTRC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBP4", "url": "https://www.orthodb.org/?gene=Q3ZBP4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10300", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10300", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10300:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10300:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04847", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04847", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029851", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBP4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBP4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHFRNFNYSFSSLIACVANSEIFSESETRAKFESLFRTYDKDITFQYFKSFKRVRINFSNPLSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQENEEEDEMERMKRPKPKIIQTRRPEYTPIHLS", "length": 197, "header": "sp|Q3ZBP4-1|RCAN1_BOVIN Isoform 1 of Calcipressin-1 OS=Bos taurus OX=9913 GN=RCAN1 PE=2 SV=1 CANONICAL=Q3ZBP4-1" }, "isoforms": [ { "isoform_ac": "Q3ZBP4-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP4/entry#Q3ZBP4-1", "sequence": { "sequence": "MHFRNFNYSFSSLIACVANSEIFSESETRAKFESLFRTYDKDITFQYFKSFKRVRINFSNPLSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQENEEEDEMERMKRPKPKIIQTRRPEYTPIHLS", "length": 197, "header": "sp|Q3ZBP4-1|RCAN1_BOVIN Isoform 1 of Calcipressin-1 OS=Bos taurus OX=9913 GN=RCAN1 PE=2 SV=1 CANONICAL=Q3ZBP4-1" }, "locus": { "chromosome": "1", "start_pos": 1000621, "end_pos": 991103, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037243.4", "url": "https://www.ensembl.org/id/ENSBTAT00000037243.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037080.2", "url": "https://www.ensembl.org/id/ENSBTAP00000037080.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 108, "end_pos": 108, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP4" } ], "site_lbl": "Ser108" }, { "start_pos": 112, "end_pos": 112, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP4" } ], "site_lbl": "Ser112" }, { "start_pos": 163, "end_pos": 163, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP4" } ], "site_lbl": "Ser163" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBP4", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:539640", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539640", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YP85-1", "protein_name": "Calcipressin-1", "gene_name": "RCAN1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MESGDGGGGRGPAGREEPPLGEAREEEEETEALPPPEAEPDWSFAGGEMEAVVLQDLPTATIACNLDPRVFQDGQCRAKFESLFRTYDRDITFQYFKSFKRVRINFSNPLSAADARVQLHKTEFLGKEIKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGDKYELHAATDTTPSVVVHVCESDQENDVEEEIKKPKPKIIQTRRPDYTPSHLS", "length": 242 }, "evidence": [ { "id": "Q3ZBP4", "url": "https://omabrowser.org/oma/group/Q3ZBP4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SGX6-1", "protein_name": "Calcipressin-1", "gene_name": "RCAN1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEDGLAGSRLGAATEAAEARAQPGVTLRPFAPFSGAAEADEGSGDWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRAKFESLFRTYDKDITFQYFKSFKRVRINFSNPLSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQENEDEDEMERMKRPKPKIIQTRRPEYTPIHLS", "length": 249 }, "evidence": [ { "id": "Q3ZBP4", "url": "https://omabrowser.org/oma/group/Q3ZBP4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O35847-1", "protein_name": "Calcipressin-1", "gene_name": "RCAN1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MHFRDFNYNFSSLIACVANGDVFSESETRAKFESLFRTYDKDITFQYFKSFKRVRINFSNPLSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQENEEEEEMERMKRPKPKIIQTRRPEYTPIHLS", "length": 197 }, "evidence": [ { "id": "Q3ZBP4", "url": "https://omabrowser.org/oma/group/Q3ZBP4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P53805-1", "protein_name": "Calcipressin-1", "gene_name": "RCAN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEDGVAGPQLGAAAEAAEAAEARARPGVTLRPFAPLSGAAEADEGGGDWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRAKFESLFRTYDKDITFQYFKSFKRVRINFSNPFSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQEKEEEEEMERMRRPKPKIIQTRRPEYTPIHLS", "length": 252 }, "evidence": [ { "id": "Q3ZBP4", "url": "https://omabrowser.org/oma/group/Q3ZBP4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6IN33-1", "protein_name": "Calcipressin-1", "gene_name": "Rcan1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHFRDFNYNFSSLIACVANGDVFSESETRAKFESLFRTYDKDITFQYFKSFKRVRINFSNPLSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQEEEEEEEEEMERMKRPKPKIIQTRRPEYTPIHLS", "length": 199 }, "evidence": [ { "id": "Q3ZBP4", "url": "https://omabrowser.org/oma/group/Q3ZBP4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9JHG6-1", "protein_name": "Calcipressin-1", "gene_name": "Rcan1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEDGVAGPRLGEVAEAVEARAPRRVTLRPFAPFSAAAEGDGGGGGDWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRAKFESLFRTYDKDTTFQYFKSFKRVRINFSNPLSAADARLRLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQENEEEEEEMERMKRPKPKIIQTRRPEYTPIHLS", "length": 251 }, "evidence": [ { "id": "Q3ZBP4", "url": "https://omabrowser.org/oma/group/Q3ZBP4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": 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"SCNM1_BOVIN", "mass": { "chemical_mass": 25999.0, "monoisotopic_mass": 25999.0 }, "refseq": { "ac": "NP_001029426", "name": "sodium channel modifier 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029426" }, "gene_names": [ { "name": "SCNM1", "type": "recommended", "evidence": [ { "id": "Q3ZBR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR0" } ] }, { "name": "SCNM1", "type": "synonym", "evidence": [ { "id": "NP_001029426", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029426" } ] } ], "protein_names": [ { "name": "Sodium channel modifier 1", "type": "recommended", "evidence": [ { "id": "Q3ZBR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR0/entry#names_and_taxonomy" } ] }, { "name": "sodium channel modifier 1", "type": "synonym", "evidence": [ { "id": "NP_001029426", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029426" } ] } ], "function": [ { "annotation": "As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Plays a role in the regulation of primary cilia length and Hedgehog signaling.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR0#function" }, { "database": "UniProtKB", "id": "Q9BWG6", "url": "https://www.uniprot.org/uniprotkb/Q9BWG6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SCNM1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR0", "locus": { "chromosome": "3", "start_pos": 19641911, "end_pos": 19644982, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018070", "url": "https://www.ensembl.org/id/ENSBTAG00000018070" } ] } } ], "crossref": [ { "id": "Q3ZBR0", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBR0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018070", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018070", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505644", "url": "https://www.ncbi.nlm.nih.gov/gene/505644", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031622", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031622", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031625", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031625", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033570", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033570", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505644", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505644", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NGKYACT", "url": "https://omabrowser.org/oma/group/NGKYACT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBR0", "url": "https://www.orthodb.org/?gene=Q3ZBR0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32297", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32297", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32297:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32297:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15803", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15803", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15805", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15805", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029426", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBR0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBR0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLQLFYGKKPPGKGTEQNPRQHNELRREETTAEAPLLTQTRLITQSALHRAPHYNSCCRRKYRPEAPRPSVSRPPLPPPEVEPQGGKISREPEPEAGSQTKESATVSSPAPMSPTRRRALDHYLTLRSSGWIPDGRGRWIKDENVEFDSDEEEPPDLPLD", "length": 230, "header": "sp|Q3ZBR0-1|SCNM1_BOVIN Isoform 1 of Sodium channel modifier 1 OS=Bos taurus OX=9913 GN=SCNM1 PE=2 SV=1 CANONICAL=Q3ZBR0-1" }, "isoforms": [ { "isoform_ac": "Q3ZBR0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR0/entry#Q3ZBR0-1", "sequence": { "sequence": "MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLQLFYGKKPPGKGTEQNPRQHNELRREETTAEAPLLTQTRLITQSALHRAPHYNSCCRRKYRPEAPRPSVSRPPLPPPEVEPQGGKISREPEPEAGSQTKESATVSSPAPMSPTRRRALDHYLTLRSSGWIPDGRGRWIKDENVEFDSDEEEPPDLPLD", "length": 230, "header": "sp|Q3ZBR0-1|SCNM1_BOVIN Isoform 1 of Sodium channel modifier 1 OS=Bos taurus OX=9913 GN=SCNM1 PE=2 SV=1 CANONICAL=Q3ZBR0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 183, "end_pos": 183, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR0" } ], "site_lbl": "Ser183" }, { "start_pos": 219, "end_pos": 219, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR0" } ], "site_lbl": "Ser219" }, { "start_pos": 2, "end_pos": 2, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR0" } ], "site_lbl": "Ser2" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505644", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505644", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZSG3-1", "protein_name": "Tropomodulin 4", "gene_name": "Tmod4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSYQKELEKYRDIDEDEILRTLSPEELEQLDCELQEMDPENMLLPAGLRQRDQTKKSPTGPLDRDALLQYLEQQALEVKERDDLVPFTGEKKGKPFIQPKREIPAQEQITLEPELEEALSHATDAEMCDIAAILGMYTLMSNKQYYDAICSGEICNTEGISSVVQPDKYKPVPDEPPNPTNIEEMLKRVRSNDKELEEVNLNNIQDIPIPVLSDLCEAMKTNTYVRSFSLVATKSGDPIANAVADMLRENRSLLSLNIESNFISSTGLMAVLKAVRENATLTELRVDNQRQWPGDAVEMEMATVLEQCPSIVRFGYHFTQQGPRARAANAMTRNNELRRQQKKR", "length": 345 }, "evidence": [ { "id": "Q3ZBR0", "url": "https://omabrowser.org/oma/group/Q3ZBR0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SSY2-1", "protein_name": "Sodium channel modifier 1", "gene_name": "SCNM1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLQLFYGKKHPGKGLEPNPRQQNELRREETKAEAPLLTQTRLITQSALHRAPHYNSCCRRKNRPEAPRPSVSRSAFSPPEVESQSERISRELEPAAASQTKESATVSSPAPMSPTRRRALDHYLTLRSSGWIPDGQGRWIKDENVEFDSDEEEPPDLPLD", "length": 230 }, "evidence": [ { "id": "Q3ZBR0", "url": "https://omabrowser.org/oma/group/Q3ZBR0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H2Z2-1", "protein_name": "Sodium channel modifier 1", "gene_name": "Scnm1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLKLFYGKKQSGKKTEQKPRQQNELKTESKAEAPLLTQTRLITQSALHRAPHYSSCCRRKHRPEAPAPSVSSSPLPAPEVGLQSAKISREPETKAGSHAKESSDLLASAPISPTKRRVLNHYLTLRSSGWIPDGQGRWIKDENVEFDSDEEEPPDLPLD", "length": 229 }, "evidence": [ { "id": "Q3ZBR0", "url": "https://omabrowser.org/oma/group/Q3ZBR0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q2YDS5-1", "protein_name": "Sodium channel modifier 1", "gene_name": "scnm1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSFKREGDDQSQLNILKKRRVSDLLSNFIPDDEATLMKNGRYSCLVCSHRPVFDTVDMLVVHRKGKRHLEGMKWFYGKKNQLRREIDKRRHQDYVKAEDDRQEPSSSAPLLTQTRKITHHALLRTVPYSSCHKKASERSESSSKEHRNDLANSHLSMRTESNDSRTTVHQGPSEVKGEAKKKKKGASTLSSSVCEPLTEQRRRELDHYLKLKSSGWLQDRSGKWVKDENVEFDSDEEEPTLLPPCSESS", "length": 249 }, "evidence": [ { "id": "Q3ZBR0", "url": "https://omabrowser.org/oma/group/Q3ZBR0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9BWG6-1", "protein_name": "Sodium channel modifier 1", "gene_name": "SCNM1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLQLFYGKKQPGKERKQNPKHQNELRREETKAEAPLLTQTRLITQSALHRAPHYNSCCRRKYRPEAPGPSVSLSPMPPSEVKLQSGKISREPEPAAGPQAEESATVSAPAPMSPTRRRALDHYLTLRSSGWIPDGRGRWVKDENVEFDSDEEEPPDLPLD", "length": 230 }, "evidence": [ { "id": "Q3ZBR0", "url": "https://omabrowser.org/oma/group/Q3ZBR0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR0" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR0" } ], "pmid": "" }, { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR0" } ], "pmid": "" }, { "name": "alternative mRNA splicing, via spliceosome", "id": "GO:0000380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000380", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR0", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBR0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 230, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBR0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBR0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZBR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR0" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Bipartite nuclear localization signal", "eco_id": "ECO_0000255", "start_pos": 4, "end_pos": 20, "start_aa": "Lys", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 2, 183, 219 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBR9-1", "uniprot_ac": "Q3ZBR9", "uniprot_id": "ERMIN_BOVIN", "mass": { "chemical_mass": 32392.0, "monoisotopic_mass": 32392.0 }, "refseq": { "ac": "NP_001029971", "name": "ermin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029971" }, "gene_names": [ { "name": "ERMN", "type": "recommended", "evidence": [ { "id": "Q3ZBR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ] }, { "name": "ERMN", "type": "synonym", "evidence": [ { "id": "NP_001029971", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029971" } ] } ], "protein_names": [ { "name": "Ermin", "type": "recommended", "evidence": [ { "id": "Q3ZBR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9/entry#names_and_taxonomy" } ] }, { "name": "JN", "type": "synonym", "evidence": [ { "id": "NP_001029971", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029971" }, { "id": "Q3ZBR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9/entry#names_and_taxonomy" } ] }, { "name": "Juxtanodin", "type": "synonym", "evidence": [ { "id": "Q3ZBR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9/entry#names_and_taxonomy" } ] }, { "name": "ermin, ERM-like protein", "type": "synonym", "evidence": [ { "id": "NP_001029971", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029971" } ] }, { "name": "ermin", "type": "synonym", "evidence": [ { "id": "NP_001029971", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029971" } ] }, { "name": "juxtanodin", "type": "synonym", "evidence": [ { "id": "NP_001029971", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029971" } ] } ], "function": [ { "annotation": "Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ERMN", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9", "locus": { "chromosome": "2", "start_pos": 39016770, "end_pos": 39011315, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012912", "url": "https://www.ensembl.org/id/ENSBTAG00000012912" } ] } } ], "crossref": [ { "id": "Q3ZBR9", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBR9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012912", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012912", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617274", "url": "https://www.ncbi.nlm.nih.gov/gene/617274", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008954", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008954", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045346", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045346", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617274", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617274", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TPPYYRV", "url": "https://omabrowser.org/oma/group/TPPYYRV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBR9", "url": "https://www.orthodb.org/?gene=Q3ZBR9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47137", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47137", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47137:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47137:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF20491", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20491", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029971", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBR9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTDVPVTFSQVECNGDTPPENGQQKITKITEGASDVDGTPPHCRVEPRLDVPTERNQEKSEKLQEDILLSSSMDEKILKEKPEEKLYVVHKALTDLSLQEAAVDKMALREGHQWEKIPLSSSNQEISRQKERISEQPLEEREDEELENTALQATEIEWLGFQKSSQVDLSHSKQDEEQEVWDEEINNDDDDDCKDDEDEVRVIEFKKKNEEDTQLKEEGDASEDSPLSSPSSQPVTPDEQPTFGKKGDFSRNAYSRYNTISYRKIRKGNTKQRIDEFESMIN", "length": 282, "header": "sp|Q3ZBR9-1|ERMIN_BOVIN Isoform 1 of Ermin OS=Bos taurus OX=9913 GN=ERMN PE=2 SV=1 CANONICAL=Q3ZBR9-1" }, "isoforms": [ { "isoform_ac": "Q3ZBR9-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9/entry#Q3ZBR9-1", "sequence": { "sequence": "MTDVPVTFSQVECNGDTPPENGQQKITKITEGASDVDGTPPHCRVEPRLDVPTERNQEKSEKLQEDILLSSSMDEKILKEKPEEKLYVVHKALTDLSLQEAAVDKMALREGHQWEKIPLSSSNQEISRQKERISEQPLEEREDEELENTALQATEIEWLGFQKSSQVDLSHSKQDEEQEVWDEEINNDDDDDCKDDEDEVRVIEFKKKNEEDTQLKEEGDASEDSPLSSPSSQPVTPDEQPTFGKKGDFSRNAYSRYNTISYRKIRKGNTKQRIDEFESMIN", "length": 282, "header": "sp|Q3ZBR9-1|ERMIN_BOVIN Isoform 1 of Ermin OS=Bos taurus OX=9913 GN=ERMN PE=2 SV=1 CANONICAL=Q3ZBR9-1" }, "locus": { "chromosome": "2", "start_pos": 39016299, "end_pos": 39011572, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000143484.1", "url": "https://www.ensembl.org/id/ENSBTAT00000143484.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106368.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106368.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 225, "end_pos": 225, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ], "site_lbl": "Ser225" }, { "start_pos": 229, "end_pos": 229, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ], "site_lbl": "Ser229" }, { "start_pos": 232, "end_pos": 232, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ], "site_lbl": "Ser232" }, { "start_pos": 236, "end_pos": 236, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ], "site_lbl": "Thr236" }, { "start_pos": 72, "end_pos": 72, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ], "site_lbl": "Ser72" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:617274", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617274", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AH29-1", "protein_name": "Ermin", "gene_name": "ERMN", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTDIPVTFSRVECNGDAPPENGQQKFAEIPEEASDVDGTPPYCRVEPRLENVPPEGNPEQSEKLQGNIQLNSPMDEKILKEKPEENLYIVRKAITDLSLQETSVDEMTFRGGHQWEKIPLRSSNQEISRQKERIAEQPLEERENEDLKNEAQQATEIEWLGFRKPSQVDVFRSKHDEQEVWDEEINNDDDDYKDDEDEVRVIEFKKKNEDGSQLKEEGHAREDSPLSSPSSQPVTPDEQPPFGKKGDISRNAYSRYNTISYRKIRKGNTKQRIDEFESMMHL", "length": 282 }, "evidence": [ { "id": "Q3ZBR9", "url": "https://omabrowser.org/oma/group/Q3ZBR9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HHT6-1", "protein_name": "Ermin", "gene_name": "Ermn", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTDVPVTPSGTECNGDRPPENDQQHITQTSKGTDDADETQPYYRDEPSVEDLPARGNQEERGNTIENILPKESADEKILHENPEDDVFVVHKAIKDLSLQEASAEDIAFREGHPWKKIPLSSSDLEMSTQKENIFHQPQEHREDENTVYQATEIEWLGFRKASQVDILHSKCDEEPEVWNEEINEEDVDDCNDDEDEVRVIEFKRKHSEGSQLKEENHVRQDSPLSTPSSQPGTPEEQPVLGKKGDISRNAYSRYNTISYRKIRKGNTKQRIDEFESMMHL", "length": 281 }, "evidence": [ { "id": "Q3ZBR9", "url": "https://omabrowser.org/oma/group/Q3ZBR9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5EBJ4-1", "protein_name": "Ermin", "gene_name": "Ermn", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTDTPETLSGTECNGDRPPENGQQPSSQTRQETTDADETQAYYKVEPSLEDLPAKENQEETGNTKGNILPKGPEDEKILNENPEENLFVVHQAIKDLSLQEISAEDMAFREGHPWKKIPPNSSNLEVSRQKERTAQQQLEQRGDASTTEIEWLGFQKSRPVDILHSKCDEEEEEEEEVWNEEINEEDVDECAEEEDEVRVIEFKRKHREGSPLKEESLAREDSPLGSPGSQPGTPDEQPVFGKKGDIARNSYSRYNTISYRKIRKGNTKQRIDEFESMMHL", "length": 281 }, "evidence": [ { "id": "Q3ZBR9", "url": "https://omabrowser.org/oma/group/Q3ZBR9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5RJL0-1", "protein_name": "Ermin", "gene_name": "Ermn", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTDTPVTLSGSECNGDRPPENGQQPSSQTRKTTDADETQTYYGVEPSLQHLPAKENQEESGNSKGNVLPRGSEDEKILNENTEENLFVVHQAIQDLSLQETSAEDTVFQEGHPWKKIPLNSHNLDMSRQKERIVHQHLEQREDESAAHQATEIEWLGFQKSSQVDILHSKCDEEEEVWNEEINEEDVDECAEDEGEDEVRVIEFKRKYREGSPLKEESLAREDSPLSSPSSQPGTPDEQLVLGKKGDIARNSYSRYNTISYRKIRKGNTKQRIDEFESMMHL", "length": 282 }, "evidence": [ { "id": "Q3ZBR9", "url": "https://omabrowser.org/oma/group/Q3ZBR9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8TAM6-1", "protein_name": "Ermin", "gene_name": "ERMN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTDVPATFTQAECNGDKPPENGQQTITKISEELTDVDSPLPHYRVEPSLEGALTKGSQEERRKLQGNMLLNSSMEDKMLKENPEEKLFIVHKAITDLSLQETSADEMTFREGHQWEKIPLSGSNQEIRRQKERITEQPLKEEEDEDRKNKGHQAAEIEWLGFRKPSQADMLHSKHDEEQKVWDEEIDDDDDDNCNNDEDEVRVIEFKKKHEEVSQFKEEGDASEDSPLSSASSQAVTPDEQPTLGKKSDISRNAYSRYNTISYRKIRKGNTKQRIDEFESMMHL", "length": 284 }, "evidence": [ { "id": "Q3ZBR9", "url": "https://omabrowser.org/oma/group/Q3ZBR9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of cell projection organization", "id": "GO:0031344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031344", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ], "pmid": "" }, { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ], "pmid": "" }, { "name": "regulation of cell shape", "id": "GO:0008360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008360", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ], "pmid": "" }, { "name": "morphogenesis of a branching structure", "id": "GO:0001763", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001763", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "internode region of axon", "id": "GO:0033269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033269", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ], "pmid": "" }, { "name": "myelin sheath", "id": "GO:0043209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043209", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ], "pmid": "" }, { "name": "filopodium", "id": "GO:0030175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030175", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ], "pmid": "" }, { "name": "paranode region of axon", "id": "GO:0033270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033270", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBR9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBR9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBR9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 282, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBR9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBR9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 72, 225, 229, 232, 236 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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}, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBS1-1", "uniprot_ac": "Q3ZBS1", "uniprot_id": "MACIR_BOVIN", "mass": { "chemical_mass": 23130.0, "monoisotopic_mass": 23130.0 }, "refseq": { "ac": "NP_001069596", "name": "macrophage immunometabolism regulator", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069596" }, "gene_names": [ { "name": "MACIR", "type": "recommended", "evidence": [ { "id": "Q3ZBS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS1" } ] }, { "name": "C7H5orf30", "type": "synonym", "evidence": [ { "id": "NP_001069596", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069596" } ] }, { "name": "MACIR", "type": "synonym", "evidence": [ { "id": "NP_001069596", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069596" } ] } ], "protein_names": [ { "name": "Macrophage immunometabolism regulator", "type": "recommended", "evidence": [ { "id": "Q3ZBS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS1/entry#names_and_taxonomy" } ] }, { "name": "UNC119-binding protein C5orf30 homolog", "type": "synonym", "evidence": [ { "id": "NP_001069596", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069596" } ] }, { "name": "UPF0684 protein C5orf30 homolog", "type": "synonym", "evidence": [ { "id": "NP_001069596", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069596" } ] }, { "name": "chromosome 7 C5orf30 homolog", "type": "synonym", "evidence": [ { "id": "NP_001069596", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069596" } ] }, { "name": "macrophage immunometabolism regulator", "type": "synonym", "evidence": [ { "id": "NP_001069596", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069596" } ] } ], "function": [ { "annotation": "Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages. The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis. May play also a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B. May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS1#function" }, { "database": "UniProtKB", "id": "Q96GV9", "url": "https://www.uniprot.org/uniprotkb/Q96GV9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MACIR", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS1", "locus": { "chromosome": "7", "start_pos": 102290921, "end_pos": 102269104, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000055286", "url": 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"categories": [ "Protein Classification" ] }, { "id": "PTHR31224", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31224", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31224:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31224:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15435", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15435", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069596", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBS1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBS1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVDVNGESRSALTTLPLPVAEASSPGKAEAEKPRCSSTPCSPMRRTVSGYQILHMDSNYLVGFTTGEELLKLAQKCTGAEESKGEAVPSLRSKQLDVGLARSSRLYKTRSRYYQPYEIPAVNGRRRRRMPSSGDKCTKSLPYEPYKALHGPLPLCLLKGKRAHSKSLDYLNLDKMNIKEPADTEVLQYQLQHLTLRGDRVFARNNT", "length": 207, "header": "sp|Q3ZBS1-1|MACIR_BOVIN Isoform 1 of Macrophage immunometabolism regulator OS=Bos taurus OX=9913 GN=MACIR PE=2 SV=1 CANONICAL=Q3ZBS1-1" }, "isoforms": [ { "isoform_ac": "Q3ZBS1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS1/entry#Q3ZBS1-1", "sequence": { "sequence": "MEVDVNGESRSALTTLPLPVAEASSPGKAEAEKPRCSSTPCSPMRRTVSGYQILHMDSNYLVGFTTGEELLKLAQKCTGAEESKGEAVPSLRSKQLDVGLARSSRLYKTRSRYYQPYEIPAVNGRRRRRMPSSGDKCTKSLPYEPYKALHGPLPLCLLKGKRAHSKSLDYLNLDKMNIKEPADTEVLQYQLQHLTLRGDRVFARNNT", "length": 207, "header": "sp|Q3ZBS1-1|MACIR_BOVIN Isoform 1 of Macrophage immunometabolism regulator OS=Bos taurus OX=9913 GN=MACIR PE=2 SV=1 CANONICAL=Q3ZBS1-1" }, "locus": { "chromosome": "7", "start_pos": 102288369, "end_pos": 102287749, "strand": "-", "evidence": [ { 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"evidence": [ { "database": "UniProtKB", "id": "Q3ZBS1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS1" } ], "site_lbl": "Ser25" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538782", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538782", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B3DHS1-1", "protein_name": "Macrophage immunometabolism regulator", "gene_name": "macir", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEMDASGASRAPISVLPAAEVKSTLKPEADKPRCSSTPCSPIKSTVSGYQILHMNSNYLVGFTTGEELLKLAQKWSSPDSSNTEALPSPIKKPVDLGLHRASRIYKAKSRYYQPYDIPAVNGRRRRRMPSSGDSCLKSIVSGEPSKALHGPLPLCLLKGKRVYSKSLDYLNLDKMSLREPVDTEVLQYQLQHLNLRGERVFTRNKT", "length": 206 }, "evidence": [ { "id": "Q3ZBS1", "url": "https://omabrowser.org/oma/group/Q3ZBS1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZPS9-1", "protein_name": "Macrophage immunometabolism regulator", "gene_name": "Macir", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEMDVNGEPRSTLTTLPLPAAEGSSPGKAEAEKPRCSSTPCSPMRRTVSGYQILHMDSNYLVGFTTGEELLKLAQKCTGGEDSKGEAMPPLRSRQLDAGLARSSRLYKTRSRYYQPYEIPAVNGRRRRRMPSSGDKCTKSLPYEPYKALHGPLPLCLLKGKRAHSKSLDYLNLDKMSIKEPADTEVLQYQLQHLTLRGDRVFARNNT", "length": 207 }, "evidence": [ { "id": "Q3ZBS1", "url": "https://omabrowser.org/oma/group/Q3ZBS1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HQD1-1", "protein_name": "Macrophage immunometabolism regulator", "gene_name": "Macir", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEVDINGESRSTLTTLPLPVAEGSSPGKAEAEKPRCSSTPCSPMRRTVSGYQILHMDSNYLVGFATGEELLKLAQKCTGGEESQGEAMPPFRSKQLDAGLARSSRLYKTRSRYYQPYEIPAVNGRRRRRMPSSGDKCTKSLPYEPYKALHGPLPLCLLKGKRAHSKSLDYLNLDKMSIKEPADTEVLQYQLQHLTLRGDRVFARNNT", "length": 207 }, "evidence": [ { "id": "Q3ZBS1", "url": "https://omabrowser.org/oma/group/Q3ZBS1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LQ30-1", "protein_name": "Macrophage immunometabolism regulator", "gene_name": "MACIR", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEVDVNGESRSTLTSLPLPVAEASSPGKAEAEKPRCSSTPCSPMRRTVSGYQILHMDSNYLVGFTTGEELLKLAQKCTGGEESKGEAVPSLRSKQLDAGLARSSRLYKTRSRYYQPYEIPAVNGRRRRRMPSSGDKCTKSLPYEPYKALHGPLPLCLLKGKRAHSKSLDYLNLDKMNIKEPADTEVLQYQLQHLTLRGDRVFARNNT", "length": 207 }, "evidence": [ { "id": "Q3ZBS1", "url": "https://omabrowser.org/oma/group/Q3ZBS1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8VEB3-1", "protein_name": "Macrophage immunometabolism regulator", "gene_name": "Macir", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEVDINGDSRSTLTTLPLPVAEGSSPGKAEAEKPRCSSTPCSPMRRTVSGYQILHMDSNYLVGFTTGEELLKLAQKCTGGEDSKGEAMPALRAKQLDTGLARSSRLYKTRSRYYQPYEIPAVNGRRRRRMPSSGDKCTKPLPYEPYKALHGPLPLCLLKGKRAHSKSLDYLNLDKMNIKEPADTEVLQYQLQHLTLRGDRVFARNNT", "length": 207 }, "evidence": [ { "id": "Q3ZBS1", "url": "https://omabrowser.org/oma/group/Q3ZBS1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96GV9-1", "protein_name": "Macrophage immunometabolism regulator", "gene_name": "MACIR", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEVDINGESRSTLTTLPFPGAEANSPGKAEAEKPRCSSTPCSPMRRTVSGYQILHMDSNYLVGFTTGEELLKLAQKCTGGEESKAEAMPSLRSKQLDAGLARSSRLYKTRSRYYQPYEIPAVNGRRRRRMPSSGDKCTKSLPYEPYKALHGPLPLCLLKGKRAHSKSLDYLNLDKMIKEPADTEVLQYQLQHLTLRGDRVFARNNT", "length": 206 }, "evidence": [ { "id": "Q3ZBS1", "url": "https://omabrowser.org/oma/group/Q3ZBS1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "R4GHF6-1", "protein_name": "Macrophage immunometabolism regulator", "gene_name": "MACIR", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEVDINGESRSAISTLPVPMAEVSAAGRTEAEKPRCSSTPCSPMRRTVSGYQILHMDSNYLVGFATGEELLKLAQKCTGNEESKGESGPNLRSKQLDSGLARSSRLYKARSRYYQPYEIPAVNGRRRRRMPSSGDKCTKALPHEPYKALHGPLPLCLLKGKRAHSKSLDYLNLDKMSIKEPADTEVLQYQLQHLTLRGDRMFARNNT", "length": 207 }, "evidence": [ { "id": "Q3ZBS1", "url": "https://omabrowser.org/oma/group/Q3ZBS1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "negative regulation of fibroblast migration", "id": "GO:0010764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010764", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS1" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": 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"GO:1900016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900016", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS1" } ], "pmid": "" }, { "name": "ciliary transition zone", "id": "GO:0035869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035869", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBS1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBS1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { 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"sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBT0-1", "uniprot_ac": "Q3ZBT0", "uniprot_id": "CPZIP_BOVIN", "mass": { "chemical_mass": 40536.0, "monoisotopic_mass": 40536.0 }, "refseq": { "ac": "NP_001029590", "name": "capZ-interacting protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029590" }, "gene_names": [ { "name": "RCSD1", "type": "recommended", "evidence": [ { "id": "Q3ZBT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT0" } ] }, { "name": "CAPZIP", "type": "synonym", "evidence": [ { "id": "Q3ZBT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT0" } ] }, { "name": "RCSD1", "type": "synonym", "evidence": [ { "id": "NP_001029590", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029590" } ] } ], "protein_names": [ { "name": "CapZ-interacting protein", "type": 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"kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZBT2-1", "uniprot_ac": "Q3ZBT2", "uniprot_id": "FBX9_BOVIN", "mass": { "chemical_mass": 50817.0, "monoisotopic_mass": 50817.0 }, "refseq": { "ac": "NP_001029584", "name": "F-box only protein 9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029584" }, "gene_names": [ { "name": "FBXO9", "type": "recommended", "evidence": [ { "id": "Q3ZBT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT2" } ] }, { "name": "FBXO9", "type": "synonym", "evidence": [ { "id": "NP_001029584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029584" } ] } ], "protein_names": [ { "name": "F-box only protein 9", "type": "recommended", "evidence": [ { "id": "Q3ZBT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT2/entry#names_and_taxonomy" } ] }, { "name": "F-box only protein 9", "type": "synonym", "evidence": [ { "id": "NP_001029584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029584" } ] } ], "function": [ { "annotation": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway (By similarity). Also regulates PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT2#function" }, { "database": "UniProtKB", "id": "Q9UK97", "url": "https://www.uniprot.org/uniprotkb/Q9UK97#function" }, { "database": "UniProtKB", "id": "Q8BK06", "url": "https://www.uniprot.org/uniprotkb/Q8BK06#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO9", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT2", "locus": { "chromosome": "23", "start_pos": 25297258, "end_pos": 25275775, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015083", "url": "https://www.ensembl.org/id/ENSBTAG00000015083" } ] } } ], "crossref": [ { "id": "Q3ZBT2", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBT2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015083", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015083", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22089", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22089", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511798", "url": "https://www.ncbi.nlm.nih.gov/gene/511798", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511798", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511798", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RWNRLDF", "url": "https://omabrowser.org/oma/group/RWNRLDF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBT2", "url": "https://www.orthodb.org/?gene=Q3ZBT2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12874", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12874", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12874:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12874:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19270", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19270", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029584", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBT2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBT2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEAEEDCHSEAVREGDDDDENESPAETDLQAQLQRFRAQWMFELAPGGGSGNLESRPCRAARGSLLRAADTRGKQELAKEEKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGNSYIEDTDDDSKMADLLSYFQQQLTFQESVLKLCQPELESSQTHISALPMEVLMYVFRWVVSSDLDLRSLEQLSQVCRGFYICARDPEIWRLACLKVWGRSCIKLVPYTSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYVRFFPDGHVMMLTTPEEPQSIVPRLRTRNTRTDAILLGHYRLSQDTDNQTKVFAVITKKKEEKALDHKYRYFRRAPVQEADQNFHVGLQLCSSGHQSFNKLIWIHHSCHITYKSTGETAVTAFEIDKMYTPLLFARVRSYTAFSERPL", "length": 437, "header": "sp|Q3ZBT2-1|FBX9_BOVIN Isoform 1 of F-box only protein 9 OS=Bos taurus OX=9913 GN=FBXO9 PE=2 SV=2 CANONICAL=Q3ZBT2-1" }, "isoforms": [ { "isoform_ac": "Q3ZBT2-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT2/entry#Q3ZBT2-1", "sequence": { "sequence": "MAEAEEDCHSEAVREGDDDDENESPAETDLQAQLQRFRAQWMFELAPGGGSGNLESRPCRAARGSLLRAADTRGKQELAKEEKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGNSYIEDTDDDSKMADLLSYFQQQLTFQESVLKLCQPELESSQTHISALPMEVLMYVFRWVVSSDLDLRSLEQLSQVCRGFYICARDPEIWRLACLKVWGRSCIKLVPYTSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYVRFFPDGHVMMLTTPEEPQSIVPRLRTRNTRTDAILLGHYRLSQDTDNQTKVFAVITKKKEEKALDHKYRYFRRAPVQEADQNFHVGLQLCSSGHQSFNKLIWIHHSCHITYKSTGETAVTAFEIDKMYTPLLFARVRSYTAFSERPL", "length": 437, "header": "sp|Q3ZBT2-1|FBX9_BOVIN Isoform 1 of F-box only protein 9 OS=Bos taurus OX=9913 GN=FBXO9 PE=2 SV=2 CANONICAL=Q3ZBT2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 126, "end_pos": 126, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT2" } ], "site_lbl": "Ser126" } ], "glycation": [], "keywords": [], "publication": [ { "title": "A whole-genome assembly of the domestic cow, Bos taurus.", "journal": "Genome Biol.", "date": "2009", "authors": "Zimin Aleksey V, Delcher Arthur L, Florea Liliana, Kelley David R, Schatz Michael C, Puiu Daniela, Hanrahan Finnian, Pertea Geo, Van Tassell Curtis P, Sonstegard Tad S, Mar\u00e7ais Guillaume, Roberts Michael, Subramanian Poorani, Yorke James A, Salzberg Steven L", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT2" } ], "reference": [ { "type": "PubMed", "id": "19393038", "url": "https://glygen.org/publication/PubMed/19393038" } ] } ], "pathway": [ { "id": "bta:511798", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511798", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7JMJ2-1", "protein_name": "F-box only protein", "gene_name": "Fbxo9", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSAEAEEDCHSDAVRVGDDENESPAERDLQAQLQMFRAQWMFELAPGVGSSNLETRPCRAGRGSILKAAADTKGRQELAKEEKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGNSYIEDNDDDSKMADLLSYFQQQLTFQESVLKLCQPELETSQTHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWRLACLKVWGRSCMKLVPYSSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYIRFFPDGHVMMLTTPEEPQSIVPRLRTRNTRTDAILLGHYRLTQDADNQTKVFAVITKKKEDKPLDYKYRYFRRVPVQEADHSFHVGLQLCSSGHQRFNKLIWIHHSCHITYKSTGETAVSAFEIDKMYTPLLFARVRSYTAFSERPL", "length": 437 }, "evidence": [ { "id": "Q3ZBT2", "url": "https://omabrowser.org/oma/group/Q3ZBT2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1S7C6-1", "protein_name": "F-box only protein", "gene_name": "FBXO9", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAEAEEDCHSDAARAGDDDEKDSSAETDLQAQLQMFRAQWMFELAPGGGSSSLETRPYTASRGSLLKAADTKGKQELAKEEKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGNSYIEDEDEDEDSKTADLLAYFQQQLTFQESVLKLCQPELESSQTHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSQVCRGFYICARDPEIWRLACLKVWGRSCMKLVPYTSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYIRFFPDGHVMMLTTPEEPPSIVPRLRTRNTRTEAILLGHYRLSQDTDNQTKVFAVITKKKEEKPLDYKYRYFRRVPVQEADQSFHVGLQLCSSGHQRFNKLIWIHHSCHITYKSTGETAVTAFEMDKMYTPLLFARVRSYTAFSERPL", "length": 438 }, "evidence": [ { "id": "Q3ZBT2", "url": "https://omabrowser.org/oma/group/Q3ZBT2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q12347-1", "protein_name": "F-box protein HRT3", "gene_name": "HRT3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MIVDYEKDPRAKEAIAIWEKGVLKEKDGSMSDAINFYRSALKIHDNVESLYRKKILDEWMLHKKLSGLSMTTDAPDEQNETGKDDLSVEENAELQPCWILEILPDDILLRIIKKVILMSGESWVNLSMTCSTFSKLCFHDSVPFKTFAKYIYSKQIYDKMAMDLNGITDINTFEKEIWRGDDYRMLRERPYIKFEGVYISVVNYVRYGSNAESSLSLLKPVHMITYYRYFRFYENGQCLRLLSTDEPSAVVKHFSKENKPRHSHMCYWSLGFDYDFGHLKITRSDEKYTFIEEFQIKNQGNKRYQRLKWLSSIVVDKEGNASNCSLRNEKSFFFSRVKSFKDPG", "length": 344 }, "evidence": [ { "id": "Q3ZBT2", "url": "https://omabrowser.org/oma/group/Q3ZBT2/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q5U2X1-1", "protein_name": "F-box only protein 9", "gene_name": "Fbxo9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEAEEDCHSDAVRVGDEGHESPAERDLQAQLQMFRAQWMFELTPGVGSSNVESRPCRAGRSSILKAAADKGRQELAKEEKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGSSYIEDNEDASKMADLLSYFQQQLTFQESVLKLCQPELETSQTHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWRLACLKVWGRSCMKLVPFSSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYIRFFPDGHVMMLTTPEEPPSIVPRLRTRNTRTDAILLGHYRLSQDADNQTKVFAVITKKKEEKPLDHKYRYFRRVPVQEADHNFHVGLQLCSSGHQRFNKLIWIHHSCHITYRSTGETAVSAFDIDKMYTPLFFARVRSYTAFSERPL", "length": 435 }, "evidence": [ { "id": "Q3ZBT2", "url": "https://omabrowser.org/oma/group/Q3ZBT2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6P3K3-1", "protein_name": "F-box only protein 9", "gene_name": "fbxo9", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAESNQNTDGAVEEGEDENTGDSNLQMELSAFRAKWMSELQPSSGGQRSFSRNAELRRRQETAKEEKARELFLKAVEEEQNGAVYEAIKYYKSAMQLVPDIEFKINYSRTPDPERGGSYLESSENNREIDDLLTYFQHQLTLGNDAMKLCEHETETSQVHISALPFEVLMYIFRWVVSCDLDLRALEQLSLVCRGFYICARDPEIWRSACLRVWGRSCTKMLPYSSWREMFLERPRVRFDGVYISKTSYIRQGEESLDGFYRAWHQVEYYRYLRFFPDGQVMMLTTPEDPLVTVPRLRSKNSRMDSIMFGHYRLSQDTDNQTKVYVVVSKRKEEKVSEYQRSRFCRRNPVPEAERSFHVGLQLSSGGRQRFNKLVWIHHSCHITYRSTGETVVTAFDVDKMYTPLFFARVKSYTAFSERPL", "length": 421 }, "evidence": [ { "id": "Q3ZBT2", "url": "https://omabrowser.org/oma/group/Q3ZBT2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8BK06-1", "protein_name": "F-box only protein 9", "gene_name": "Fbxo9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAEAEEDCHSDADRVGDEGNESPAERDLQAQLQMFRAQWMFELTPGVGSSHGETRPCRAGRSSMLKAAADTKGRQELAKEEKARELFLQAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGSGYIEENEDASKMADLLSYFQQQLTLQESVLKLCQPELETSQTHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWRLACLKVWGRSCMKLVPYASWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYMRFFPDGHVMMLTTPEEPPSIVPRLRTRNTRTDAILLGHYRLSQDADNQTKVFAVITKKKEEKPLDHKYRYFRRVPVQEADHSFHVGLQLCSSGHQRFNKLIWIHHSCHITYKATGETAVSAFEIDKMYTPLLFARVRSYTAFSERPL", "length": 437 }, "evidence": [ { "id": "Q3ZBT2", "url": "https://omabrowser.org/oma/group/Q3ZBT2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UK97-1", "protein_name": "F-box only protein 9", "gene_name": "FBXO9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPDIIWVFPPQAEAEEDCHSDTVRADDDEENESPAETDLQAQLQMFRAQWMFELAPGVSSSNLENRPCRAARGSLQKTSADTKGKQEQAKEEKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGNSYIEDNDDDSKMADLLSYFQQQLTFQESVLKLCQPELESSQIHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWRLACLKVWGRSCIKLVPYTSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYIRFFPDGHVMMLTTPEEPQSIVPRLRTRNTRTDAILLGHYRLSQDTDNQTKVFAVITKKKEEKPLDYKYRYFRRVPVQEADQSFHVGLQLCSSGHQRFNKLIWIHHSCHITYKSTGETAVSAFEIDKMYTPLFFARVRSYTAFSERPL", "length": 447 }, "evidence": [ { "id": "Q3ZBT2", "url": "https://omabrowser.org/oma/group/Q3ZBT2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VG61-1", "protein_name": "F-box only protein 9", "gene_name": "Dmel\\CG5961", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSDVDSDGEEPTRKTGTNALDEFRENWQRELQEHTTNTGSRSHSEAGDRLTAANSNLSEADLLQAKAESLYRTAVQLEQRGKVYDALPFYRKATQIVPDIEFRFYEQQKQKLSNDVSKKYLNLANDLAKQLDLGQSDGEEVVDNLYEKFQHDLRQKNIYNGKMIASSRDANVLTTGLHFADLPPEIVMRILRWVVSAQLDMRSLEQCAAVCKGFYVYARDEELWRLACVKVWGHNVGTLEAQDSDVSNVFHSWRDMFIRRDRVLFNGCYISKTTYLRMGENSFQDQFYRPVQLVEYYRYIRFLPDGKVLMMTTADEPAQGVSKLKHVNNVRAEMLRGRYRLFGSTVTLVLQKSQQRGPANVRQRRGSIMPVDEDSSQFLIELRIAGTTKRRCAQLVWSHYTLVQKRNKVDISSEFDLTEAKYPALRFSTVKSYHLDADAPLA", "length": 442 }, "evidence": [ { "id": "Q3ZBT2", "url": "https://omabrowser.org/oma/group/Q3ZBT2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT2" } ], "pmid": "" }, { "name": "SCF ubiquitin ligase complex", "id": "GO:0019005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019005", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT2" } ], "pmid": "" }, { "name": "regulation of TOR signaling", "id": "GO:0032006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032006", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT2" } ], "pmid": "" }, { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBT2", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" }, { "start_pos": 337, "end_pos": 339, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBT2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 437, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBT2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBT2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZBT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBT2" }, { "id": "PRU00080", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00080" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-box", "eco_id": "ECO_0000255", "start_pos": 175, "end_pos": 226, "start_aa": "Gln", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 126 ], "sequon_annotation_sites": [ { "start_pos": 22, "end_pos": 24 }, { "start_pos": 337, "end_pos": 339 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 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"table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q3ZBV1-1", "uniprot_ac": "Q3ZBV1", "uniprot_id": "IST1_BOVIN", "mass": { "chemical_mass": 39791.0, "monoisotopic_mass": 39791.0 }, "refseq": { "ac": "NP_001029507", "name": "IST1 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029507" }, "gene_names": [ { "name": "IST1", "type": "recommended", "evidence": [ { "id": "Q3ZBV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV1" } ] }, { "name": "CHMP8", "type": "synonym", "evidence": [ { "id": "NP_001029507", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029507" } ] }, { "name": "IST1", "type": "synonym", "evidence": [ { "id": "NP_001029507", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029507" } ] } ], "protein_names": [ { "name": "IST1 homolog", "type": "recommended", "evidence": [ { "id": "Q3ZBV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV1/entry#names_and_taxonomy" } ] }, { "name": "CHMP8", "type": "synonym", "evidence": [ { "id": "Q3ZBV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV1/entry#names_and_taxonomy" } ] }, { "name": "Charged multivesicular body protein 8", "type": "synonym", "evidence": [ { "id": "Q3ZBV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV1/entry#names_and_taxonomy" } ] }, { "name": "IST1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001029507", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029507" } ] }, { "name": "IST1, ESCRT-III associated factor", "type": "synonym", "evidence": [ { "id": "NP_001029507", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029507" } ] }, { "name": "charged multivesicular body protein 8", "type": "synonym", "evidence": [ { "id": "NP_001029507", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029507" } ] } ], "function": [ { "annotation": "ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (By similarity). Is required for efficient abscission during cytokinesis (By similarity). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (By similarity). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (By similarity). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (By similarity). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV1#function" }, { "database": "UniProtKB", "id": "P53990", "url": "https://www.uniprot.org/uniprotkb/P53990#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IST1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV1", "locus": { "chromosome": "18", "start_pos": 39164240, "end_pos": 39179416, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019883", "url": "https://www.ensembl.org/id/ENSBTAG00000019883" } ] } } ], "crossref": [ { "id": "Q3ZBV1", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBV1", "database": "AlphaFoldDB", "categories": [] }, { "id": "508900", "url": "https://www.ncbi.nlm.nih.gov/gene/508900", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005061", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005061", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042277", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042277", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508900", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508900", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3ZBV1", "url": "https://www.orthodb.org/?gene=Q3ZBV1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12161", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12161", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12161:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12161:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03398", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03398", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029507", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBV1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBV1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGSGIKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGGGGFTAPVGGPDGTVPMPMPMPMPSPNTPFSYPLPKGPSDFNGLPVGTYQAFPNIHPPQIPATPPSYESVDDINADKNVSSTQIVGPGPKPEPPAKPASRLTETYDNFVLPELPSVPDTLPTASPGANTSASEDIDFDDLSRRFEELKKKT", "length": 364, "header": "sp|Q3ZBV1-1|IST1_BOVIN Isoform 1 of IST1 homolog OS=Bos taurus OX=9913 GN=IST1 PE=2 SV=1 CANONICAL=Q3ZBV1-1" }, "isoforms": [ { "isoform_ac": "Q3ZBV1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV1/entry#Q3ZBV1-1", "sequence": { "sequence": "MLGSGIKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGGGGFTAPVGGPDGTVPMPMPMPMPSPNTPFSYPLPKGPSDFNGLPVGTYQAFPNIHPPQIPATPPSYESVDDINADKNVSSTQIVGPGPKPEPPAKPASRLTETYDNFVLPELPSVPDTLPTASPGANTSASEDIDFDDLSRRFEELKKKT", "length": 364, "header": "sp|Q3ZBV1-1|IST1_BOVIN Isoform 1 of IST1 homolog OS=Bos taurus OX=9913 GN=IST1 PE=2 SV=1 CANONICAL=Q3ZBV1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 43, "end_pos": 43, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV1" } ], "site_lbl": "Tyr43" }, { "start_pos": 4, "end_pos": 4, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV1" } ], "site_lbl": "Ser4" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508900", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508900", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV1" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV1" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV1" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV1" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV1" } ], "pmid": "" }, { "name": "intracellular protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBV1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBV1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" }, { "start_pos": 341, "end_pos": 343, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZBV1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 364, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZBV1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZBV1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 4, 43 ], "sequon_annotation_sites": [ { "start_pos": 291, "end_pos": 293 }, { "start_pos": 341, "end_pos": 343 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"categories": [ "Protein Classification" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030452", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBZ1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBZ1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASRQAPLCGLAPCCLWLLGVVLLMNASARPANHSSARERAGNREENEILPPDHLNGVKLEMDGHLNKDFHQEVFLGKDMDDFEEDAEPRKSRRKLMVIFSKVDLNTDRRISAKEMQKWIMQKTAEHFQEAVAESRAHFRAVDPDGDGHVSWDEYKVKFLATKGHNEREVAEKIKNKWDLNIDEETQEVLENLKDRWYQADNPPPDLLLTESEFLSFLHPEHSRGMLQFMVKEIIRDLDQDGDKKLSLSEFISLPVGTVENQQGQDVDDSWVRDRKREFEELIDANHDGIVTMAELEDYMDPMNEFSALNEAKQMIAIADENQNHYLEPEEVLKYSEFFTGSKLVDYARSVHEEF", "length": 355, 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"id": "NP_001030569", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030569" } ] }, { "name": "hsc70/Hsp90-organizing protein", "type": "synonym", "evidence": [ { "id": "NP_001030569", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030569" } ] }, { "name": "stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein)", "type": "synonym", "evidence": [ { "id": "NP_001030569", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030569" } ] }, { "name": "stress-induced-phosphoprotein 1", "type": "synonym", "evidence": [ { "id": "NP_001030569", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030569" } ] } ], "function": [ { "annotation": "Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBZ8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBZ8#function" }, { "database": "UniProtKB", "id": "O35814", "url": "https://www.uniprot.org/uniprotkb/O35814#function" }, { "database": "UniProtKB", "id": "P31948", "url": "https://www.uniprot.org/uniprotkb/P31948#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZBZ8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBZ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STIP1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBZ8", "locus": { "chromosome": "29", "start_pos": 42508869, "end_pos": 42496125, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015663", "url": "https://www.ensembl.org/id/ENSBTAG00000015663" } ] } } ], "crossref": [ { "id": "Q3ZBZ8", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZBZ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015663", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015663", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617109", "url": "https://www.ncbi.nlm.nih.gov/gene/617109", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006636", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006636", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041243", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041243", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617109", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617109", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MYSAREN", "url": "https://omabrowser.org/oma/group/MYSAREN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZBZ8", "url": "https://www.orthodb.org/?gene=Q3ZBZ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22904", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22904", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22904:SF523", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22904:SF523", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13181", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13181", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13414", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13414", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13424", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13424", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17830", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17830", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3371497", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371497", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9696273", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696273", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030569", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030569", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZBZ8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZBZ8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQVNELKEKGNKALSAGNIDDALQCYSEAIKLDPQNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKQTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNPFNMPNLYQKLESDPRTKTLLADPTYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLLGVDLGSMDEEEEVATPPPPPPPKKETKPEPMEEDLPENKKQALREKELGNEAYKKKDFDTALKHYDKAKDLDPTNMTYITNQAAVYFEKGDYGQCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSNCKEAADGYQRCVMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKIQKLMDVGLIAIR", "length": 543, "header": "sp|Q3ZBZ8-1|STIP1_BOVIN Isoform 1 of Stress-induced-phosphoprotein 1 OS=Bos taurus OX=9913 GN=STIP1 PE=2 SV=1 CANONICAL=Q3ZBZ8-1" }, "isoforms": [ { "isoform_ac": "Q3ZBZ8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZBZ8/entry#Q3ZBZ8-1", "sequence": { "sequence": "MEQVNELKEKGNKALSAGNIDDALQCYSEAIKLDPQNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKQTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNPFNMPNLYQKLESDPRTKTLLADPTYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLLGVDLGSMDEEEEVATPPPPPPPKKETKPEPMEEDLPENKKQALREKELGNEAYKKKDFDTALKHYDKAKDLDPTNMTYITNQAAVYFEKGDYGQCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSNCKEAADGYQRCVMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKIQKLMDVGLIAIR", "length": 543, "header": "sp|Q3ZBZ8-1|STIP1_BOVIN Isoform 1 of Stress-induced-phosphoprotein 1 OS=Bos taurus OX=9913 GN=STIP1 PE=2 SV=1 CANONICAL=Q3ZBZ8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 16, "end_pos": 16, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBZ8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBZ8" } ], "site_lbl": "Ser16" }, { "start_pos": 198, "end_pos": 198, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBZ8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBZ8" } ], "site_lbl": "Thr198" }, { "start_pos": 332, "end_pos": 332, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBZ8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBZ8" } ], "site_lbl": "Thr332" }, { "start_pos": 354, "end_pos": 354, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBZ8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBZ8" } ], "site_lbl": "Tyr354" }, { "start_pos": 481, "end_pos": 481, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZBZ8", "url": "https://www.uniprot.org/uniprotkb/Q3ZBZ8" } ], "site_lbl": "Ser481" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617109", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617109", "resource": "KEGG Pathway" }, { "id": "R-BTA-3371497", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371497", "resource": "Reactome", "description": "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" }, { "id": "R-BTA-9696273", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696273", "resource": "Reactome", "description": "RND1 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D1UVZ9-1", "protein_name": "Stress-induced-phosphoprotein 1", "gene_name": "STIP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEQVNELKEKGNKALSAGNIDDALQCYSEAIKLDPQNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNPFNMPNLYQKLESDPRTKALLADPSYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLLGVDLGSMDEEEEVATPPPPPPPKKEPKPEPMEEDLPENKKQALKEKELGNEAYKKKDFDTALKHYDRAKDLDPTNMTYMTNQAAVYFEKGDYGKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDANCKEAADGYQRCVMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKIQKLMDVGLIAIR", "length": 543 }, "evidence": [ { "id": "Q3ZBZ8", "url": "https://omabrowser.org/oma/group/Q3ZBZ8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O35814-1", "protein_name": "Stress-induced-phosphoprotein 1", "gene_name": "Stip1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEQVNELKEKGNKALSAGNIDDALQCYSEAIKLDPQNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNLQLKEGLQNMEARLAERKFMNPFNLPNLYQKLENDPRTRTLLSDPTYRELIEQLQNKPSDLGTKLQDPRVMTTLSVLLGVDLGSMDEEEEAATPPPPPPPKKEAKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDKALKHYDKAKELDPTNMTYITNQAAVHFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEERYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPRDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKIQKLMDVGLIAIR", "length": 543 }, "evidence": [ { "id": "Q3ZBZ8", "url": "https://omabrowser.org/oma/group/Q3ZBZ8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P15705-1", "protein_name": "Heat shock protein STI1", "gene_name": "STI1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSLTADEYKQQGNAAFTAKDYDKAIELFTKAIEVSETPNHVLYSNRSACYTSLKKFSDALNDANECVKINPSWSKGYNRLGAAHLGLGDLDEAESNYKKALELDASNKAAKEGLDQVHRTQQARQAQPDLGLTQLFADPNLIENLKKNPKTSEMMKDPQLVAKLIGYKQNPQAIGQDLFTDPRLMTIMATLMGVDLNMDDINQSNSMPKEPETSKSTEQKKDAEPQSDSTTSKENSSKAPQKEESKESEPMEVDEDDSKIEADKEKAEGNKFYKARQFDEAIEHYNKAWELHKDITYLNNRAAAEYEKGEYETAISTLNDAVEQGREMRADYKVISKSFARIGNAYHKLGDLKKTIEYYQKSLTEHRTADILTKLRNAEKELKKAEAEAYVNPEKAEEARLEGKEYFTKSDWPNAVKAYTEMIKRAPEDARGYSNRAAALAKLMSFPEAIADCNKAIEKDPNFVRAYIRKATAQIAVKEYASALETLDAARTKDAEVNNGSSAREIDQLYYKASQQRFQPGTSNETPEETYQRAMKDPEVAAIMQDPVMQSILQQAQQNPAALQEHMKNPEVFKKIQTLIAAGIIRTGR", "length": 589 }, "evidence": [ { "id": "Q3ZBZ8", "url": "https://omabrowser.org/oma/group/Q3ZBZ8/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P31948-1", "protein_name": "Stress-induced-phosphoprotein 1", "gene_name": "STIP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKIQKLMDVGLIAIR", "length": 543 }, "evidence": [ { "id": "Q3ZBZ8", "url": "https://omabrowser.org/oma/group/Q3ZBZ8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54DA8-1", "protein_name": "Protein STIP1 homolog", "gene_name": "sti1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSENAQKATEFKNQGNAAFSSKDYNSAVKCFDQAIELDPSNHILYSNRSASLLALDKNEDALTDAKKAIELKPDWSKGYLRETNALYKLGRFEEAEKSAEAGLKIDPTNQQLEDALEDAQYATTGAKDPASAMANLFSAQNLTKLRFNPKTAPFFQQPDFVAIMDQISKNPSLFSQYIADQRFSTCLGVLLGVDINQGPGAPPQSQQPTPQQPTPTPQQPTPTPQQPKPTEAPKKPEAPPMTESQKERDLGNKAYAKKEFEQAIVHYDKAVELDSSDILAMNNKAAVLIEQQKLDEAIETCKKALEKAQEIRADYRVKSKVYTRLGNIYLKKNQLDDAYKAYSSAVLEDKNADTTANMKKIEKLKKQRDDEAYLSVDQSIIEKNKGVEHFKKGEFPEAIKCFEEAIRRNPKDHTIYSNRSAAYSKLLEYKLAIKDADKCIELEPTFIKGYIRKGTALFAMREYQQALEVYDQGLRIEANNPELLDLSRKTVAALTKLQSTLTDEERLQQAAKDPEIQKILSDPIMNQILKDMSENPAAAQDHLKNPLIMAKFQKLVNAGIVKLG", "length": 564 }, "evidence": [ { "id": "Q3ZBZ8", "url": "https://omabrowser.org/oma/group/Q3ZBZ8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q60864-1", "protein_name": "Stress-induced-phosphoprotein 1", "gene_name": "Stip1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEQVNELKEKGNKALSAGNIDDALQCYSEAIKLDPQNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNLQLKEGLQNMEARLAERKFMNPFNLPNLYQKLENDPRTRSLLSDPTYRELIEQLQNKPSDLGTKLQDPRVMTTLSVLLGVDLGSMDEEEEAATPPPPPPPKKEPKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDKALKHYDRAKELDPTNMTYITNQAAVHFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPRDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKIQKLMDVGLIAIR", "length": 543 }, "evidence": [ { "id": "Q3ZBZ8", "url": "https://omabrowser.org/oma/group/Q3ZBZ8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9STH1-1", "protein_name": "Hsp70-Hsp90 organizing protein 3", "gene_name": "HOP3", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAEEAKSKGNAAFSSGDYATAITHFTEAINLSPTNHILYSNRSASYASLHRYEEALSDAKKTIELKPDWSKGYSRLGAAFIGLSKFDEAVDSYKKGLEIDPSNEMLKSGLADASRSRVSSKSNPFVDAFQGKEMWEKLTADPGTRVYLEQDDFVKTMKEIQRNPNNLNLYMKDKRVMKALGVLLNVKFGGSSGEDTEMKEADERKEPEPEMEPMELTEEERQKKERKEKALKEKGEGNVAYKKKDFGRAVEHYTKAMELDDEDISYLTNRAAVYLEMGKYEECIEDCDKAVERGRELRSDFKMIARALTRKGSALVKMARCSKDFEPAIETFQKALTEHRNPDTLKKLNDAEKVKKELEQQEYFDPTIAEEEREKGNGFFKEQKYPEAVKHYSEAIKRNPNDVRAYSNRAACYTKLGALPEGLKDAEKCIELDPSFTKGYSRKGAIQFFMKEYDKAMETYQEGLKHDPKNQEFLDGVRRCVEQINKASRGDLTPEELKERQAKAMQDPEVQNILSDPVMRQVLVDFQENPKAAQEHMKNPMVMNKIQKLVSAGIVQVR", "length": 558 }, "evidence": [ { "id": "Q3ZBZ8", "url": "https://omabrowser.org/oma/group/Q3ZBZ8/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VPN5-1", "protein_name": "Stress-induced-phosphoprotein 1", "gene_name": "Stip1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": 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"uniprot_canonical_ac": "Q3ZC48-1", "uniprot_ac": "Q3ZC48", "uniprot_id": "DRAM2_BOVIN", "mass": { "chemical_mass": 29923.0, "monoisotopic_mass": 29923.0 }, "refseq": { "ac": "NP_001070464", "name": "DNA damage-regulated autophagy modulator protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070464" }, "gene_names": [ { "name": "DRAM2", "type": "recommended", "evidence": [ { "id": "Q3ZC48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC48" } ] }, { "name": "DRAM2", "type": "synonym", "evidence": [ { "id": "NP_001070464", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070464" } ] }, { "name": "TMEM77", "type": "synonym", "evidence": [ { "id": "NP_001070464", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070464" }, { "id": "Q3ZC48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC48" } ] } ], "protein_names": [ { "name": "DNA damage-regulated autophagy modulator protein 2", "type": "recommended", "evidence": [ { "id": "Q3ZC48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC48/entry#names_and_taxonomy" } ] }, { "name": "DNA damage-regulated autophagy modulator protein 2", "type": "synonym", "evidence": [ { "id": "NP_001070464", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070464" } ] }, { "name": "Transmembrane protein 77", "type": "synonym", "evidence": [ { "id": "Q3ZC48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC48/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 77", "type": "synonym", "evidence": [ { "id": "NP_001070464", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070464" } ] } ], "function": [ { "annotation": "Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC48", "url": "https://www.uniprot.org/uniprotkb/Q3ZC48#function" }, { "database": "UniProtKB", "id": "Q6UX65", "url": "https://www.uniprot.org/uniprotkb/Q6UX65#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZC48", "url": "https://www.uniprot.org/uniprotkb/Q3ZC48" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DRAM2", "url": "https://www.uniprot.org/uniprotkb/Q3ZC48", "locus": { "chromosome": "3", "start_pos": 32300437, "end_pos": 32272397, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009888", "url": "https://www.ensembl.org/id/ENSBTAG00000009888" } ] } } ], "crossref": [ { "id": "Q3ZC48", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZC48", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009888", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009888", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767922", "url": "https://www.ncbi.nlm.nih.gov/gene/767922", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050911", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050911", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767922", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767922", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SEWCLAF", "url": "https://omabrowser.org/oma/group/SEWCLAF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZC48", "url": "https://www.orthodb.org/?gene=Q3ZC48", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21324", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21324", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21324:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21324:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10277", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10277", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001070464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070464", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZC48", "url": "https://www.uniprot.org/uniprotkb/Q3ZC48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZC48-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC48-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWWFQQGLSFLPSALVIWTAAAFIFSYITAITLHHVDPVLPYISDTGTVAPEKCLFGAMLNIAAVLCVATIYVRYKQVHALNPEENRIIRLNKAGLVLGLLSCLGLSLVANFQKTTFFAVHVCGAVLTFGMGSLYMFVQTILSYQMQPKIHGKQVFWIRLLLVIWCGVSAFSMLTCSSLLYNGSFGADIVQKLHWNPEDKGYVLHMITTAAEWSMSLSFFGFFLTYIRDFQKISLRVEATLHGLTLYDTAPCPVNNERTWLLSRDV", "length": 266, "header": "sp|Q3ZC48-1|DRAM2_BOVIN Isoform 1 of DNA damage-regulated autophagy modulator protein 2 OS=Bos taurus OX=9913 GN=DRAM2 PE=2 SV=1 CANONICAL=Q3ZC48-1" }, "isoforms": [ { "isoform_ac": "Q3ZC48-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC48/entry#Q3ZC48-1", "sequence": { "sequence": "MWWFQQGLSFLPSALVIWTAAAFIFSYITAITLHHVDPVLPYISDTGTVAPEKCLFGAMLNIAAVLCVATIYVRYKQVHALNPEENRIIRLNKAGLVLGLLSCLGLSLVANFQKTTFFAVHVCGAVLTFGMGSLYMFVQTILSYQMQPKIHGKQVFWIRLLLVIWCGVSAFSMLTCSSLLYNGSFGADIVQKLHWNPEDKGYVLHMITTAAEWSMSLSFFGFFLTYIRDFQKISLRVEATLHGLTLYDTAPCPVNNERTWLLSRDV", "length": 266, "header": "sp|Q3ZC48-1|DRAM2_BOVIN Isoform 1 of DNA damage-regulated autophagy modulator protein 2 OS=Bos taurus OX=9913 GN=DRAM2 PE=2 SV=1 CANONICAL=Q3ZC48-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767922", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767922", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1A1G7-1", "protein_name": "DNA damage regulated autophagy modulator 2", "gene_name": "DRAM2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MWWFQQGLSFLPVALVVWSAATFVFSYITAIVLRHVDPLVPYISDTGTIPPERCLFGIMLNVSSFLGMATMYVRYKQVYALNPDKSRIVKLNKIGLTLGLMSCFGLCIIANFQKCILYYIHVVGACLTFGVGAIYMLVQTILSYLMQPEVHSKDIFWIRLTVLLWCGSSIASMFVSSLVLYSGLYGTDLVQKLHWDPQEKGYTAHIVSTASEWSLAFSFLSFFLTYIRDFQKISLRAVVSLHGQTLYNTPQSFATDEQRLLIAGSI", "length": 266 }, "evidence": [ { "id": "Q3ZC48", "url": "https://omabrowser.org/oma/group/Q3ZC48/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1R7U0-1", "protein_name": "DNA damage-regulated autophagy modulator protein 2b isoform X1", "gene_name": "dram2b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMWWFQEGLCVLPVALVVWTAATFIFAYITAVVLRHVDPLVPYISDTGTVAPERCVFGVMLNVSAFLGVATMYVRYKQLQALADVEDTRLNRLNVVGFVFGCCSSFGMCVVANFQKTTLFSMHLVGAILTFGIGALYVFIQTALSYLMQPHIHSKTMFWTRLSVGIWTLSSIISMFVSSVIMYSTLPGVEVNKKLHWTPGEPGFTAHIVSTISEWSLALSFISFFLTYIRDFKKINLRASAELQSNHLYESQHYRPVSARGPTETSPLLTGSI", "length": 273 }, "evidence": [ { "id": "Q3ZC48", "url": "https://omabrowser.org/oma/group/Q3ZC48/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1S630-1", "protein_name": "DNA damage regulated autophagy modulator 2", "gene_name": "DRAM2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MWWFQQGLSFLPSALLIWTAAAFIFSYITAITLHHVDPVLPYISDTGTVAPEKCLFGAMLNIAAVLCVATIYVRYKQVHALNPEENCIIRLNKAGLVLGLLSCLGLSVVANFQKTTFFAVHVCGAILTFGMGSLYMFVQTILSYQMQPKIHGKQVFWIRLLLVIWCGVSALIMLTCSSLLYSSSFGTDIVQKLHWNPEDKGYALHMITAAAEWSMSFSFFGFFLTYIRDFQKISLRVEANLHGLTLYDTAPCPVNNERTRLLSRDI", "length": 266 }, "evidence": [ { "id": "Q3ZC48", "url": "https://omabrowser.org/oma/group/Q3ZC48/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q559G4-1", "protein_name": "CWH43-like N-terminal domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MISSKTTQIKPFYILCIISLIVPITFITTYAITEVRGDDDQIIPYISDTIDFAPESCIGTFGLSIIAFLMIIVVFIKHLIIKNNIIEKEYFDDKKEKKELRFNRFSTSMGFISGLSMHGVSSFQFHNANLVHVIFAALFFLCGFIYLLTQTILDIKNSSDIPLKVLIIRKILICISCLFIGYIITQFFIDNLAAIFEIMSALSIFAYMVTFFYEFSNLTLNIEFSKSIKKINGNGGYHNIESN", "length": 243 }, "evidence": [ { "id": "Q3ZC48", "url": "https://omabrowser.org/oma/group/Q3ZC48/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6UX65-1", "protein_name": "DNA damage-regulated autophagy modulator protein 2", "gene_name": "DRAM2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWWFQQGLSFLPSALVIWTSAAFIFSYITAVTLHHIDPALPYISDTGTVAPEKCLFGAMLNIAAVLCIATIYVRYKQVHALSPEENVIIKLNKAGLVLGILSCLGLSIVANFQKTTLFAAHVSGAVLTFGMGSLYMFVQTILSYQMQPKIHGKQVFWIRLLLVIWCGVSALSMLTCSSVLHSGNFGTDLEQKLHWNPEDKGYVLHMITTAAEWSMSFSFFGFFLTYIRDFQKISLRVEANLHGLTLYDTAPCPINNERTRLLSRDI", "length": 266 }, "evidence": [ { "id": "Q3ZC48", "url": "https://omabrowser.org/oma/group/Q3ZC48/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CR48-1", "protein_name": "DNA damage-regulated autophagy modulator protein 2", "gene_name": "Dram2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWWFQQGLSFLPSALVIWTFATFIFSYITAITLHHVDPALPYISDTGTIPPERCLFGVMLNIAAVLGIATMYVRYKQVHALNPEENLIIKLNKAGLVLGILSCLGLSLVANFQKSTLFIVHVCGAVLAFSMGSFYMFVQTILSYQMQPKIHSKQVFWVRLLLVIWCGVSALSMMTCSSILYSSDFGPDVVQKLHWNPEDKGYVLHLVTTAAEWSMSFSFFGFFLTYIRDFQKITLRVEANLHGLTLYDTVPCPVNNERTPLLSRDFQ", "length": 267 }, "evidence": [ { "id": "Q3ZC48", "url": "https://omabrowser.org/oma/group/Q3ZC48/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "regulation of autophagy", "id": "GO:0010506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010506", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC48", "url": "https://www.uniprot.org/uniprotkb/Q3ZC48" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC48", "url": "https://www.uniprot.org/uniprotkb/Q3ZC48" } ], "pmid": "" }, { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC48", "url": "https://www.uniprot.org/uniprotkb/Q3ZC48" } ], "pmid": "" }, { "name": "photoreceptor cell maintenance", "id": "GO:0045494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045494", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC48", "url": "https://www.uniprot.org/uniprotkb/Q3ZC48" } ], "pmid": "" }, { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC48", "url": "https://www.uniprot.org/uniprotkb/Q3ZC48" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC48", "url": "https://www.uniprot.org/uniprotkb/Q3ZC48" } ], "pmid": "" 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"MKDPSRSSTSPSIINEDVIINGHSHEDDNPFAEYMWMENEEEFNRQIEEELWEEEFIERCFQEMLEEEEEHEWFIPARDLPQTMDQIQDQFNDLVISDGSSLEDLVVKSNLNPNAKEFVPGVKY", "length": 124, "header": "sp|Q3ZC67-1|PAIP2_BOVIN Isoform 1 of Polyadenylate-binding protein-interacting protein 2 OS=Bos taurus OX=9913 GN=PAIP2 PE=2 SV=1 CANONICAL=Q3ZC67-1" }, "isoforms": [ { "isoform_ac": "Q3ZC67-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC67/entry#Q3ZC67-1", "sequence": { "sequence": "MKDPSRSSTSPSIINEDVIINGHSHEDDNPFAEYMWMENEEEFNRQIEEELWEEEFIERCFQEMLEEEEEHEWFIPARDLPQTMDQIQDQFNDLVISDGSSLEDLVVKSNLNPNAKEFVPGVKY", "length": 124, "header": "sp|Q3ZC67-1|PAIP2_BOVIN Isoform 1 of Polyadenylate-binding protein-interacting protein 2 OS=Bos taurus OX=9913 GN=PAIP2 PE=2 SV=1 CANONICAL=Q3ZC67-1" }, "locus": { "chromosome": "7", "start_pos": 50645033, "end_pos": 50641115, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010815.4", "url": "https://www.ensembl.org/id/ENSBTAT00000010815.4" }, { "database": "Ensembl 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"tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKDPSRSSTSPSIINEDVIINGHSHEDDNPFAEYMWMENEEEFNRQIEEELWEEEFIERCFQEMLEEEEEHEWFIPARDLPQTMDQIQDQFNDLVISDGSSLEDLVVKSNLNPNAKEFVPGVKY", "length": 124 }, "evidence": [ { "id": "Q3ZC67", "url": "https://omabrowser.org/oma/group/Q3ZC67/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5ZJS6-1", "protein_name": "Polyadenylate-binding protein-interacting protein 2", "gene_name": "PAIP2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKDPSRSSTSPSIISEDVIINGHSHEDDNPFAEYMWMENEEEFNRQIEEELWEEEFIERCFQEMLEEEEEHEWFIPARDLPQTMDQIQDQFNDLVISDSSSLEDLVVKSNLNPNAKEFVPGVKYLNI", "length": 127 }, "evidence": [ { "id": "Q3ZC67", "url": "https://omabrowser.org/oma/group/Q3ZC67/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6AXZ0-1", "protein_name": "Polyadenylate-binding protein-interacting protein 2", "gene_name": "Paip2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKDPSRSSTSPSIINDDVIINGHSHEEDNPFAEYMWMENEEEFNRQIEEELWEEEFIERCFQEMLEEEEEHEWFIPARDLPQTMDQIQDQFNDLVISDGSSLEDLVVKSNLNPNAKEFVPGVKY", "length": 124 }, "evidence": [ { "id": "Q3ZC67", "url": "https://omabrowser.org/oma/group/Q3ZC67/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9BPZ3-1", "protein_name": "Polyadenylate-binding protein-interacting protein 2", "gene_name": "PAIP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKDPSRSSTSPSIINEDVIINGHSHEDDNPFAEYMWMENEEEFNRQIEEELWEEEFIERCFQEMLEEEEEHEWFIPARDLPQTMDQIQDQFNDLVISDGSSLEDLVVKSNLNPNAKEFVPGVKYGNI", "length": 127 }, "evidence": [ { "id": "Q3ZC67", "url": "https://omabrowser.org/oma/group/Q3ZC67/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D6V8-1", "protein_name": "Polyadenylate-binding 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"MQANSSAKSLPTECPDYQPIHHLHLVVYSVVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPLRLSYYARHYWPFPDFLCQLAGAVFQMNMYGSCIFLTLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPTILAHQPSSCARDGRNVSLCFESFSDKLWKGSLLPLLLLAEALGFLLPLAAVVYSSGRVFWTLARPDATRSQRRRKTVRLLLASLVIFLLCFVPYNATLAVYGLLRGEVVPASSEARKKVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGLRAPLRDRTLAANGAQEALAEPLTETAHASTLTTTSQGQLQPSDPRSSFTPSHEDSSF", "length": 367, "header": "sp|Q3ZC80-1|LPAR5_BOVIN Isoform 1 of Lysophosphatidic acid receptor 5 OS=Bos taurus OX=9913 GN=LPAR5 PE=2 SV=1 CANONICAL=Q3ZC80-1" }, "isoforms": [ { "isoform_ac": "Q3ZC80-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZC80/entry#Q3ZC80-1", "sequence": { "sequence": "MQANSSAKSLPTECPDYQPIHHLHLVVYSVVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPLRLSYYARHYWPFPDFLCQLAGAVFQMNMYGSCIFLTLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPTILAHQPSSCARDGRNVSLCFESFSDKLWKGSLLPLLLLAEALGFLLPLAAVVYSSGRVFWTLARPDATRSQRRRKTVRLLLASLVIFLLCFVPYNATLAVYGLLRGEVVPASSEARKKVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGLRAPLRDRTLAANGAQEALAEPLTETAHASTLTTTSQGQLQPSDPRSSFTPSHEDSSF", "length": 367, "header": "sp|Q3ZC80-1|LPAR5_BOVIN Isoform 1 of Lysophosphatidic acid receptor 5 OS=Bos taurus OX=9913 GN=LPAR5 PE=2 SV=1 CANONICAL=Q3ZC80-1" }, "locus": { "chromosome": "5", "start_pos": 103810574, "end_pos": 103810304, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119896.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119896.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089293.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089293.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 170, "start_aa": "Asn", "end_pos": 170, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn170", "evidence": [ { "id": "Q3ZC80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC80#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 4, "start_aa": "Asn", "end_pos": 4, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn4", "evidence": [ { "id": "Q3ZC80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC80#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:507598", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507598", "resource": "KEGG Pathway" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" }, { "id": "R-BTA-419408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-419408", "resource": "Reactome", "description": "Lysosphingolipid and LPA receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287ABI5-1", "protein_name": "Lysophosphatidic acid receptor 5", "gene_name": "LPAR5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLANFTNPLTSGPVFKCPDHQSTHRLHLVVYSLVLATGLPLNALALWVFLRELRVHSVVSVYMCNLAASDLLFTLSLPLRLSYYARHYWPFSDLLCQLASAVFQMNMYGSCIFLTLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPTVLAHRPSSCIRNDSHEVHLCFENFSDELWKGRLLPLLLLAEALGFLLPLAAVVYSSGCVFWTLARPDATRSHRRRKTVRLLLASLVIFLLCFVPYNATLAVYGLLRGNVVPASTSAREQVREVLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGLSTPLRTRTSATTPPEQPAEPAHAIGTGTAASQGLLGPSKLGSSFTQCPEDSCL", "length": 367 }, "evidence": [ { "id": "Q3ZC80", "url": "https://omabrowser.org/oma/group/Q3ZC80/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZDJ0-1", "protein_name": "Lysophosphatidic acid receptor 5", "gene_name": "LPAR5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSAANVSQPCKDYSFYHKLLLPGYILIFITGLTLNVMALWIFVRYLRLKSVVMIYMFNLAVSDLTFTLPLPLRLYYYFNHEWPFGNTLCQVSGSVFQINMYGSCIFLMCINLDRYIAIVHPLRWRHLRRPKVARLLCLVVWVVILMGSIPTAIVHKQNHCESQNQTTYLCFESFSDNMWQKNLFPLVVLAEILGFLLPLSAVTYCSIQIFRELCQTRQPKTLRQQKTVRLLLVNLVIFVIFFVPYNTTLAVYGLIKARVIDVEKQMQASVREVLIVTMMLASMNCTLDPLIYYFSTEGFRNTFKKLRRGQTWHSDTGVIRNQVVEQKSTRNHAASTAKQLPSENFHCPGEAVPALPTTVFLNGPIEDSEI", "length": 370 }, "evidence": [ { "id": "Q3ZC80", "url": "https://omabrowser.org/oma/group/Q3ZC80/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4ADR1-1", "protein_name": "Lysophosphatidic acid receptor 5", "gene_name": "Lpar5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPQTSFSPHLDAMFANSSANTSSTDSSVPQCRDYRSTHRLHMVVYSLVLATGLPLNALALWVFLRVLRVHSVVSVYMCNLAASDLLFTLSLPLRLSYYARHHWPFPDFLCQTSGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPLVARRLCLGVWALILLFAVPAARVHSPTTCKYENVTLSLCFESFSDELWKGRLLPLLLLAETLGFLLPLAAVVYSSGRVFWTLARPDATQSHRRQKTVRLLLANLIIFLLCFVPYNSTLAVYGLLRANLVKNSLQARDQVRGVLMIMVLLAGANCVLDPLVYYFSAEGFRNTLRNLGAPFHTRPLPTNGTRGELTEPPSESTQNTGQDATSQRLLQPANLGTRTDNGPQDSAL", "length": 384 }, "evidence": [ { "id": "Q3ZC80", "url": "https://omabrowser.org/oma/group/Q3ZC80/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q149R9-1", "protein_name": "Lysophosphatidic acid receptor 5", "gene_name": "Lpar5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFANSSANTTSTNSSVLQCPDYRDTHRLHMVVYSLVLATGLPLNALALWVFLRVLRVHSVVSVYMCNLAASDLLFTLSLPLRLSYYAQHHWPFPGFLCQTSGAIFQMNMYGSCLFLMLINVDRYAAIVHPLRLRHLRRPRVARRLCLGVWALILLFAVPAARVHSPSHCTYKNITVRLCFESFSDELWKGRLLPLLLLAEILGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLIIFLLCFVPYNSTLAVYGLLRANLVKNSIQDRDQVRGVLMIMVLLAGANCVLDPLVYYFSAEGFRNTLRNLGAPLNTRPLATNGAAGVLTELPSESTQNTGQDATSQVLLQPATLGTPPDNCSQDSAL", "length": 372 }, "evidence": [ { "id": "Q3ZC80", "url": "https://omabrowser.org/oma/group/Q3ZC80/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H1C0-1", "protein_name": "Lysophosphatidic acid receptor 5", "gene_name": "LPAR5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGLGTPHRARTSATNGTRAALAQSERSAVTTDATRPDAASQGLLRPSDSHSLSSFTQCPQDSAL", "length": 372 }, "evidence": [ { "id": "Q3ZC80", "url": "https://omabrowser.org/oma/group/Q3ZC80/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC80", "url": "https://www.uniprot.org/uniprotkb/Q3ZC80" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC80", "url": "https://www.uniprot.org/uniprotkb/Q3ZC80" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "behavioral response to pain", "id": "GO:0048266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048266", "evidence": [ { "database": "UniProtKB", "id": "Q3ZC80", "url": "https://www.uniprot.org/uniprotkb/Q3ZC80" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 250, "end_pos": 252, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZC80-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 367, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZC80-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZC80" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 4, 170 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 170, "end_pos": 172 }, { "start_pos": 250, "end_pos": 252 }, { "start_pos": 4, "end_pos": 6 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { 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"site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZCB8-1", "uniprot_ac": "Q3ZCB8", "uniprot_id": "EMC3_BOVIN", "mass": { "chemical_mass": 29920.0, "monoisotopic_mass": 29920.0 }, "refseq": { "ac": "NP_001030228", "name": "ER membrane protein complex subunit 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030228" }, "gene_names": [ { "name": "EMC3", "type": "recommended", "evidence": [ { "id": "Q3ZCB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB8" } ] }, { "name": "EMC3", "type": "synonym", "evidence": [ { "id": "NP_001030228", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030228" } ] }, { "name": "TMEM111", "type": "synonym", "evidence": [ { "id": "NP_001030228", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030228" }, { "id": "Q3ZCB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB8" } ] } ], "protein_names": [ { "name": "ER membrane protein complex subunit 3", "type": "recommended", "evidence": [ { "id": "Q3ZCB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB8/entry#names_and_taxonomy" } ] }, { "name": "ER membrane protein complex subunit 3", "type": "synonym", "evidence": [ { "id": "NP_001030228", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030228" } ] }, { "name": "Transmembrane protein 111", "type": "synonym", "evidence": [ { "id": "Q3ZCB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB8/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 111", "type": "synonym", "evidence": [ { "id": "NP_001030228", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030228" } ] } ], "function": [ { "annotation": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCB8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB8#function" }, { "database": "UniProtKB", "id": "Q9P0I2", "url": "https://www.uniprot.org/uniprotkb/Q9P0I2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCB8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EMC3", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB8", "locus": { "chromosome": "22", "start_pos": 16803771, "end_pos": 16789209, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003882", "url": "https://www.ensembl.org/id/ENSBTAG00000003882" } ] } } ], "crossref": [ { "id": "Q3ZCB8", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCB8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003882", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003882", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508371", "url": "https://www.ncbi.nlm.nih.gov/gene/508371", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002809", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002809", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008568", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008568", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508371", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508371", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DSINMID", "url": "https://omabrowser.org/oma/group/DSINMID/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZCB8", "url": "https://www.orthodb.org/?gene=Q3ZCB8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13116", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13116", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13116:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13116:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01956", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01956", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030228", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZCB8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCB8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKLTQEQVSDSQVLIRSRVLRENGKYIPKQSFLTRKYYFNNPEDGFFKKTKRKVVPPSPVTDPTMLTDMMKGNVTNVLPMILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLRSIYSLILGQDNAADQSRMMQEQMTGAAMAMPADTNKAFKTEWEALELTDHQWALDDVEEELMAKDLHFEGMFKKELQTSIF", "length": 261, "header": "sp|Q3ZCB8-1|EMC3_BOVIN Isoform 1 of ER membrane protein complex subunit 3 OS=Bos taurus OX=9913 GN=EMC3 PE=2 SV=3 CANONICAL=Q3ZCB8-1" }, "isoforms": [ { "isoform_ac": "Q3ZCB8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB8/entry#Q3ZCB8-1", "sequence": { "sequence": "MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKLTQEQVSDSQVLIRSRVLRENGKYIPKQSFLTRKYYFNNPEDGFFKKTKRKVVPPSPVTDPTMLTDMMKGNVTNVLPMILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLRSIYSLILGQDNAADQSRMMQEQMTGAAMAMPADTNKAFKTEWEALELTDHQWALDDVEEELMAKDLHFEGMFKKELQTSIF", "length": 261, "header": "sp|Q3ZCB8-1|EMC3_BOVIN Isoform 1 of ER membrane protein complex subunit 3 OS=Bos taurus OX=9913 GN=EMC3 PE=2 SV=3 CANONICAL=Q3ZCB8-1" }, "locus": { "chromosome": "22", "start_pos": 16803402, "end_pos": 16789354, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005064.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005064.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005064.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005064.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508371", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508371", "resource": "KEGG Pathway" }, { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1UUJ9-1", "protein_name": "ER membrane protein complex subunit 3", "gene_name": "EMC3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKLTQEQVSDSQVLIRSRVLRENGKYIPKQSFLTRKYYFNNPEDGFFKKTKRKVVPPSPMTDPTMLTDMMKGNVTNVLPMILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLRSIYSLILGQDNAADQSRMMQEQMTGAAVAMPADTNKAFKTEWEALELTDHQWALDDVEEELMAKDLHFEGMFKKELQTSIF", "length": 261 }, "evidence": [ { "id": "Q3ZCB8", "url": "https://omabrowser.org/oma/group/Q3ZCB8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "E1BQV4-1", "protein_name": "ER membrane protein complex subunit 3", "gene_name": "EMC3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSEPELLLDSNIRLWVVLPIVFITFFVGMIRHYVSILLQSDKRLTQEQVSDSQVLIRSRVLRENGKYIPKQSFLTRKYYFNNPEDGFFKKTKRKVVPPSPMTDPTMLTDMMKGNVTNVLPMILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLRSIYTLILGQDNAADQSRVMQEQMTGAAMAMPADTNKAFKTEWEALELTDHQWALEDVEEELMAKDLHFEGMFKEELQTSIF", "length": 261 }, "evidence": [ { "id": "Q3ZCB8", "url": "https://omabrowser.org/oma/group/Q3ZCB8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3GX34-1", "protein_name": "ER membrane protein complex subunit 3", "gene_name": "Emc3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKLTQEQVSDSQVLIRSRVLRENGKYIPKQSFLTRKYYFNNPEDGFFKKTKRKVVPPSPMTDPTMLTDMMKGNVTNVLPMILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLRSIYSLILGQDNAADQSRMMQEQMTGAAMAMPADTNKAFKTEWEALELTDHQWALDDVEEELMSRDLHFEGMFKKELQTSIF", "length": 261 }, "evidence": [ { "id": "Q3ZCB8", "url": "https://omabrowser.org/oma/group/Q3ZCB8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5U2V8-1", "protein_name": "ER membrane protein complex subunit 3", "gene_name": "Emc3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKLTQEQVSDSQVLIRSRVLRENGKYIPKQSFLTRKYYFNNPEDGFFKKTKRKVVPPSPMTDPTMLTDMMKGNVTNVLPMILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLRSIYSLILGQDNAADQSRMMQEQMTGAAMAMPADTNKAFKTEWEALELTDHQWALDDVEEELMARDLHFEGMFKKELQTSIF", "length": 261 }, "evidence": [ { "id": "Q3ZCB8", "url": "https://omabrowser.org/oma/group/Q3ZCB8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7SXW4-1", "protein_name": "ER membrane protein complex subunit 3", "gene_name": "emc3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAEPELLLDSNIRLWVVLPIVFITFLVGVIRHYVSILLQSDKKLTLEQVSDSQVLIRSRVLRENGKYIPKQSFLMRKFYFNNQEDGFFKKTKRKVVPPSPMTDPSMLTDMMKGNVTNVLPMILIGGWINWTFSGFVTTKVPFPLTLRFKPMLQQGIELLSLDASWVSSASWYFLNVFGLRSMYSLILGQDNGADQSRIMQEQMSGAAMAMPADTNKAFKAEWEALELTDHQWALENVEEDLMSKDLDLSGMFSKDLPTGIF", "length": 261 }, "evidence": [ { "id": "Q3ZCB8", "url": "https://omabrowser.org/oma/group/Q3ZCB8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q99KI3-1", "protein_name": "ER membrane protein complex subunit 3", "gene_name": "Emc3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKLTQEQVSDSQVLIRSRVLRENGKYIPKQSFLTRKYYFNNPEDGFFKKTKRKVVPPSPMTDPTMLTDMMKGNVTNVLPMILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLRSIYSLILGQDNAADQSRMMQEQMTGAAMAMPADTNKAFKTEWEALELTDHQWALDDVEEELMARDLHFEGMFKKELQTSIF", "length": 261 }, "evidence": [ { "id": "Q3ZCB8", "url": "https://omabrowser.org/oma/group/Q3ZCB8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P0I2-1", "protein_name": "ER membrane protein complex subunit 3", "gene_name": "EMC3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKLTQEQVSDSQVLIRSRVLRENGKYIPKQSFLTRKYYFNNPEDGFFKKTKRKVVPPSPMTDPTMLTDMMKGNVTNVLPMILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLRSIYSLILGQDNAADQSRMMQEQMTGAAMAMPADTNKAFKTEWEALELTDHQWALDDVEEELMAKDLHFEGMFKKELQTSIF", "length": 261 }, "evidence": [ { "id": "Q3ZCB8", "url": "https://omabrowser.org/oma/group/Q3ZCB8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9SU27-1", "protein_name": "ER membrane protein complex subunit 3", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAEDLVLDTAIRDWVLIPLSVVMVLIGILRYFVSKLMRSTPTPDAKMVKEGQVVIRARNLKVGANFIPPKSFRARRFYFSNEENGLLHVPKGEAQNPQAAMFSDPNMAMDMMKKNLSMIIPQTLTFAWVNFFFSGFVAAKIPFPLTQRFRSMLQNGIDLSTVDVSYVSSRSWYFLNLFGLRGLFSLILGDENAIDDTQRMMQMGGFGFDASKSLGAEKDGLDIIQHEWALPRFEQRAESVLRKLVK", "length": 246 }, "evidence": [ { "id": "Q3ZCB8", "url": "https://omabrowser.org/oma/group/Q3ZCB8/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "EMC complex", "id": "GO:0072546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072546", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCB8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCB8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB8" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCB8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "tail-anchored membrane protein insertion into ER membrane", "id": "GO:0071816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071816", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCB8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB8" } ], "pmid": "" }, { "name": "protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "id": "GO:0045050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045050", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCB8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "membrane insertase activity", "id": "GO:0032977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032977", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCB8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCB8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" }, { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCB8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 261, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCB8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCB8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 114, "end_pos": 116 }, { "start_pos": 129, "end_pos": 131 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZCD8-1", "uniprot_ac": "Q3ZCD8", "uniprot_id": "MFF_BOVIN", "mass": { "chemical_mass": 25060.0, "monoisotopic_mass": 25060.0 }, "refseq": { "ac": "NP_001029439", "name": "mitochondrial fission factor isoform 10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029439" }, "gene_names": [ { "name": "MFF", "type": "recommended", "evidence": [ { "id": "Q3ZCD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8" } ] }, { "name": "C2H2orf33", "type": "synonym", "evidence": [ { "id": "NP_001029439", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029439" } ] }, { "name": "C2orf33", "type": "synonym", "evidence": [ { "id": "NP_001029439", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029439" } ] }, { "name": "MFF", "type": "synonym", "evidence": [ { "id": "NP_001029439", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029439" } ] } ], "protein_names": [ { "name": "Mitochondrial fission factor", "type": "recommended", "evidence": [ { "id": "Q3ZCD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial fission factor isoform 10", "type": "synonym", "evidence": [ { "id": "NP_001029439", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029439" } ] } ], "function": [ { "annotation": "Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCD8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8#function" }, { "database": "UniProtKB", "id": "Q6PCP5", "url": "https://www.uniprot.org/uniprotkb/Q6PCP5#function" }, { "database": "UniProtKB", "id": "Q9GZY8", "url": "https://www.uniprot.org/uniprotkb/Q9GZY8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCD8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MFF", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8", "locus": { "chromosome": "2", "start_pos": 115514827, "end_pos": 115486535, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021319", "url": "https://www.ensembl.org/id/ENSBTAG00000021319" } ] } } ], "crossref": [ { "id": "Q3ZCD8", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCD8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021319", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021319", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506291", "url": "https://www.ncbi.nlm.nih.gov/gene/506291", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008518", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008518", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506291", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506291", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3ZCD8", "url": "https://www.orthodb.org/?gene=Q3ZCD8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16501", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16501", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16501:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16501:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05644", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05644", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029439", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZCD8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCD8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEISRIQYEMEYTEGISQRMRVPEKLKVAPPNADLEQGFQEGVSNASVIMQVPERIVVAGNNEDIPFSRPADLDLIQSTPFKPLALKTPPRVLTLSERPLDFLDLERPAPTPQNEEIRAVGRLKRERSMSENAVRQNGQLVKTDSMYGISNIDAMIEGTSEDMTVVDAASLRRQIIKLNRRLQLLEEENKERAKREMVMYSITVAFWLLNSWLWFRR", "length": 218, "header": "sp|Q3ZCD8-1|MFF_BOVIN Isoform 1 of Mitochondrial fission factor OS=Bos taurus OX=9913 GN=MFF PE=2 SV=1 CANONICAL=Q3ZCD8-1" }, "isoforms": [ { "isoform_ac": "Q3ZCD8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8/entry#Q3ZCD8-1", "sequence": { "sequence": "MAEISRIQYEMEYTEGISQRMRVPEKLKVAPPNADLEQGFQEGVSNASVIMQVPERIVVAGNNEDIPFSRPADLDLIQSTPFKPLALKTPPRVLTLSERPLDFLDLERPAPTPQNEEIRAVGRLKRERSMSENAVRQNGQLVKTDSMYGISNIDAMIEGTSEDMTVVDAASLRRQIIKLNRRLQLLEEENKERAKREMVMYSITVAFWLLNSWLWFRR", "length": 218, "header": "sp|Q3ZCD8-1|MFF_BOVIN Isoform 1 of Mitochondrial fission factor OS=Bos taurus OX=9913 GN=MFF PE=2 SV=1 CANONICAL=Q3ZCD8-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 112, "start_aa": "Thr", "end_pos": 112, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr112", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 129, "end_pos": 129, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCD8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8" } ], "site_lbl": "Ser129" }, { "start_pos": 131, "end_pos": 131, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCD8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8" } ], "site_lbl": "Ser131" }, { "start_pos": 146, "end_pos": 146, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCD8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8" } ], "site_lbl": "Ser146" }, { "start_pos": 171, "end_pos": 171, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCD8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8" } ], "site_lbl": "Ser171" }, { "start_pos": 89, "end_pos": 89, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCD8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8" } ], "site_lbl": "Thr89" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:506291", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506291", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCD8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8" } ], "pmid": "" }, { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCD8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8" } ], "pmid": "" }, { "name": "synaptic vesicle", "id": "GO:0008021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCD8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCD8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein targeting to mitochondrion", "id": "GO:0006626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006626", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCD8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8" } ], "pmid": "" }, { "name": "mitochondrial fission", "id": "GO:0000266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000266", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCD8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8" } ], "pmid": "" }, { "name": "positive regulation of mitochondrial fission", "id": "GO:0090141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090141", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCD8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCD8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCD8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 218, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCD8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCD8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 112 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 89, 129, 131, 146, 171 ], "sequon_annotation_sites": [ { "start_pos": 46, "end_pos": 48 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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}, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZCE0-1", "uniprot_ac": "Q3ZCE0", "uniprot_id": "LSM8_BOVIN", "mass": { "chemical_mass": 10403.0, "monoisotopic_mass": 10403.0 }, "refseq": { "ac": "NP_001029912", "name": "LSM8 homolog, U6 small nuclear RNA associated", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029912" }, "gene_names": [ { "name": "LSM8", "type": "recommended", "evidence": [ { "id": "Q3ZCE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCE0" } ] }, { "name": "LSM8", "type": "synonym", "evidence": [ { "id": "NP_001029912", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029912" } ] }, { "name": "NAA38", "type": "synonym", "evidence": [ { "id": "NP_001029912", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029912" } ] } ], "protein_names": [ { "name": "U6 snRNA-associated Sm-like protein LSm8", "type": "recommended", "evidence": [ { "id": "Q3ZCE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCE0/entry#names_and_taxonomy" } ] }, { "name": "LSM8 homolog, U6 small nuclear RNA associated", "type": "synonym", "evidence": [ { "id": "NP_001029912", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029912" } ] }, { "name": "U6 snRNA-associated Sm-like protein LSm8", "type": "synonym", "evidence": [ { "id": "NP_001029912", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029912" } ] } ], "function": [ { "annotation": "Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCE0", "url": "https://www.uniprot.org/uniprotkb/Q3ZCE0#function" }, { "database": "UniProtKB", "id": "O95777", "url": "https://www.uniprot.org/uniprotkb/O95777#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCE0", "url": "https://www.uniprot.org/uniprotkb/Q3ZCE0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LSM8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCE0", "locus": { "chromosome": "4", "start_pos": 82805846, "end_pos": 82786232, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012649", "url": "https://www.ensembl.org/id/ENSBTAG00000012649" } ] } } ], "crossref": [ { "id": "Q3ZCE0", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCE0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012649", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012649", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01727", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01727", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613630", "url": "https://www.ncbi.nlm.nih.gov/gene/613630", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001163", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010920", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010920", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044642", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044642", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047575", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047575", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613630", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613630", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AACDQTT", "url": "https://omabrowser.org/oma/group/AACDQTT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZCE0", "url": "https://www.orthodb.org/?gene=Q3ZCE0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15588", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15588", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15588:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15588:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01423", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01423", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029912", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZCE0", "url": "https://www.uniprot.org/uniprotkb/Q3ZCE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCE0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCE0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSALENYINRTVAVITSDGRMIVGTLKGFDQTINLILDESHERVFSSSQGVEQVVLGLYIVRGDNVAVIGEIDEETDSALDLGNIRAEPLNSVAH", "length": 96, "header": "sp|Q3ZCE0-1|LSM8_BOVIN Isoform 1 of U6 snRNA-associated Sm-like protein LSm8 OS=Bos taurus OX=9913 GN=LSM8 PE=3 SV=3 CANONICAL=Q3ZCE0-1" }, "isoforms": [ { "isoform_ac": "Q3ZCE0-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCE0/entry#Q3ZCE0-1", "sequence": { "sequence": "MTSALENYINRTVAVITSDGRMIVGTLKGFDQTINLILDESHERVFSSSQGVEQVVLGLYIVRGDNVAVIGEIDEETDSALDLGNIRAEPLNSVAH", "length": 96, "header": "sp|Q3ZCE0-1|LSM8_BOVIN Isoform 1 of U6 snRNA-associated Sm-like protein LSm8 OS=Bos taurus OX=9913 GN=LSM8 PE=3 SV=3 CANONICAL=Q3ZCE0-1" }, "locus": { "chromosome": "4", "start_pos": 82793649, "end_pos": 82786434, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000150969.1", "url": "https://www.ensembl.org/id/ENSBTAT00000150969.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107448.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107448.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613630", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613630", "resource": "KEGG Pathway" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1W3A0-1", "protein_name": "U6 snRNA-associated Sm-like protein LSm8", "gene_name": "LSM8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTSALENYINRTVAVITSDGRMIVGTLKGFDQTINLILDESHERVFSSSQGVEQVVLGLYIVRGDNVAVIGEIDEETDSALDLGNIRAEPLNSVAH", "length": 96 }, "evidence": [ { "id": "Q3ZCE0", "url": "https://omabrowser.org/oma/group/Q3ZCE0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "E1BZ75-1", "protein_name": "U6 snRNA-associated Sm-like protein LSm8", "gene_name": "LSM8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTSALENYINRTVAVITSDGRMIVGTLKGFDQTINLILDESHERVFSSSQGVEQVVLGLYIVRGDNVAVIGEIDEETDSALDLGNIRAEPLNSVVH", "length": 96 }, "evidence": [ { "id": "Q3ZCE0", "url": "https://omabrowser.org/oma/group/Q3ZCE0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O95777-1", "protein_name": "U6 snRNA-associated Sm-like protein LSm8", "gene_name": "LSM8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTSALENYINRTVAVITSDGRMIVGTLKGFDQTINLILDESHERVFSSSQGVEQVVLGLYIVRGDNVAVIGEIDEETDSALDLGNIRAEPLNSVAH", "length": 96 }, "evidence": [ { "id": "Q3ZCE0", "url": "https://omabrowser.org/oma/group/Q3ZCE0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q1ZXD5-1", "protein_name": "Probable U6 snRNA-associated Sm-like protein LSm8", "gene_name": "lsm8", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MAMLESYLKKQVLVLTADGRSIIGTLRGIDQTINVVLEKCHERVYSDEGIEVIPLGVHLIKGDDVAVIGEVDDELDKKLNLKEIIAEPMKPIVH", "length": 94 }, "evidence": [ { "id": "Q3ZCE0", "url": "https://omabrowser.org/oma/group/Q3ZCE0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6ZWM4-1", "protein_name": "U6 snRNA-associated Sm-like protein LSm8", "gene_name": "Lsm8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTSALENYINRTVAVITSDGRMIVGTLKGFDQTINLILDESHERVFSSSQGVEQVVLGLYIVRGDNVAVIGEIDEETDSALDLGNIRAEPLNSVAH", "length": 96 }, "evidence": [ { "id": "Q3ZCE0", "url": "https://omabrowser.org/oma/group/Q3ZCE0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8VYI0-1", "protein_name": "Sm-like protein LSM8", "gene_name": "LSM8", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAATTGLETLVDQIISVITNDGRNIVGVLKGFDQATNIILDESHERVFSTKEGVQQHVLGLYIIRGDNIGVIGELDEELDASLDFSKLRAHPLKPVVH", "length": 98 }, "evidence": [ { "id": "Q3ZCE0", "url": "https://omabrowser.org/oma/group/Q3ZCE0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9W087-1", "protein_name": "U6 snRNA-associated Sm-like protein LSm8", "gene_name": "l(3)neo7", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSGLESYINHTVSIITADGRNFIGTLKGFDQTINIIIDECHERVFSTTSGIEQIVLGLHIIRGDNIAVIGLIDETIDSRLDLANIRGEPLGPVVH", "length": 95 }, "evidence": [ { "id": "Q3ZCE0", "url": "https://omabrowser.org/oma/group/Q3ZCE0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCE0", "url": "https://www.uniprot.org/uniprotkb/Q3ZCE0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCE0", "url": "https://www.uniprot.org/uniprotkb/Q3ZCE0" } ], "pmid": "" }, { "name": "precatalytic spliceosome", "id": "GO:0071011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071011", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCE0", "url": "https://www.uniprot.org/uniprotkb/Q3ZCE0" } ], "pmid": "" }, { "name": "Lsm2-8 complex", "id": "GO:0120115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120115", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCE0", "url": "https://www.uniprot.org/uniprotkb/Q3ZCE0" } ], "pmid": "" }, { "name": "U4/U6 x U5 tri-snRNP complex", "id": "GO:0046540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046540", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCE0", "url": "https://www.uniprot.org/uniprotkb/Q3ZCE0" } ], "pmid": "" }, { "name": "U6 snRNP", "id": "GO:0005688", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005688", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCE0", "url": "https://www.uniprot.org/uniprotkb/Q3ZCE0" } ], "pmid": "" }, { "name": "U2-type precatalytic spliceosome", "id": "GO:0071005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071005", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCE0", "url": "https://www.uniprot.org/uniprotkb/Q3ZCE0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCE0", "url": "https://www.uniprot.org/uniprotkb/Q3ZCE0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 10, "end_pos": 12, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCE0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 96, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCE0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCE0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q3ZCE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCE0" }, { "id": "PRU01346", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01346" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sm", "eco_id": "ECO_0000255", "start_pos": 1, "end_pos": 76, "start_aa": "Met", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 10, "end_pos": 12 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZCF5-1", "uniprot_ac": "Q3ZCF5", "uniprot_id": "OAT_BOVIN", "mass": { "chemical_mass": 48075.0, "monoisotopic_mass": 48075.0 }, "refseq": { "ac": "NP_001029412", "name": "ornithine aminotransferase, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029412" }, "gene_names": [ { "name": "OAT", "type": "recommended", "evidence": [ { "id": "Q3ZCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF5" } ] }, { "name": "OAT", "type": "synonym", "evidence": [ { "id": "NP_001029412", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029412" } ] } ], "protein_names": [ { "name": "Ornithine aminotransferase, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q3ZCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF5/entry#names_and_taxonomy" } ] }, { "name": "2.6.1.13", "type": "synonym", "evidence": [ { "id": "Q3ZCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF5/entry#names_and_taxonomy" } ] }, { "name": "Ornithine--oxo-acid aminotransferase", "type": "synonym", "evidence": [ { "id": "Q3ZCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF5/entry#names_and_taxonomy" } ] }, { "name": "ornithine aminotransferase (gyrate atrophy)", "type": "synonym", "evidence": [ { "id": "NP_001029412", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029412" } ] }, { "name": "ornithine aminotransferase, mitochondrial precursor", "type": "synonym", "evidence": [ { "id": "NP_001029412", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029412" } ] }, { "name": "ornithine aminotransferase, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001029412", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029412" } ] }, { "name": "ornithine--oxo-acid aminotransferase", "type": "synonym", "evidence": [ { "id": "NP_001029412", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029412" } ] } ], "function": [ { "annotation": "Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF5#function" }, { "database": "UniProtKB", "id": "P04181", "url": "https://www.uniprot.org/uniprotkb/P04181#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OAT", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF5", "locus": { "chromosome": "26", "start_pos": 44045036, "end_pos": 44064355, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006928", "url": "https://www.ensembl.org/id/ENSBTAG00000006928" } ] } } ], "crossref": [ { "id": "Q3ZCF5", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCF5", "database": "AlphaFoldDB", "categories": [] }, { "id": "2.6.1.13", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.6.1.13&UniProtAcc=Q3ZCF5", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd00610", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00610", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505323", "url": "https://www.ncbi.nlm.nih.gov/gene/505323", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005814", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005814", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049704", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049704", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505323", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505323", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3ZCF5", "url": "https://www.orthodb.org/?gene=Q3ZCF5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11986", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11986", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11986:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11986:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00202", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00202", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029412", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "25160", "url": "https://www.rhea-db.org/rhea/25160", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3ZCF5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCF5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSKLARLQTVAGLGLGVHSSVASATSVATKKTVQGPPSSDYIFERESKYGAHNYHPLPVALERGKGIYVWDVEGRKYFDFLSAYSAVNQGHCHPKIVDALKSQVDKLTLTSRAFYNNVLGEYEEYVTKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIPKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFEIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLVGVRELCTQHQVLFIADEIQTGLARTGRWLAIDHENVRPDIVLLGKALSGGLYPVSAVLCDDEIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENAEKMGIILRNELMKLPSDVVTTVRGKGLLNAIVIRETKDCDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDEILEAVEIINKTILSF", "length": 439, "header": "sp|Q3ZCF5-1|OAT_BOVIN Isoform 1 of Ornithine aminotransferase, mitochondrial OS=Bos taurus OX=9913 GN=OAT PE=2 SV=1 CANONICAL=Q3ZCF5-1" }, "isoforms": [ { "isoform_ac": "Q3ZCF5-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF5/entry#Q3ZCF5-1", "sequence": { "sequence": "MLSKLARLQTVAGLGLGVHSSVASATSVATKKTVQGPPSSDYIFERESKYGAHNYHPLPVALERGKGIYVWDVEGRKYFDFLSAYSAVNQGHCHPKIVDALKSQVDKLTLTSRAFYNNVLGEYEEYVTKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIPKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFEIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLVGVRELCTQHQVLFIADEIQTGLARTGRWLAIDHENVRPDIVLLGKALSGGLYPVSAVLCDDEIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENAEKMGIILRNELMKLPSDVVTTVRGKGLLNAIVIRETKDCDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDEILEAVEIINKTILSF", "length": 439, "header": "sp|Q3ZCF5-1|OAT_BOVIN Isoform 1 of Ornithine aminotransferase, mitochondrial OS=Bos taurus OX=9913 GN=OAT PE=2 SV=1 CANONICAL=Q3ZCF5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:505323", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505323", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF5" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF5", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0010121", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF5" } ], "pmid": "" }, { "name": "L-arginine catabolic process to L-glutamate", "id": "GO:0019544", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019544", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCF5", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 433, "end_pos": 435, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "25160", "name": "", "equation": "L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZCF5-1", "F1MYG0-1" ], "evidence": [ { "id": "25160", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/25160" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MYG0", "gene_name": "OAT", "activity": [ { "ec_number": "2.6.1.13", "activity": "L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate.", "evidence": [ { "id": "F1MYG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG0" } ] }, { "ec_number": "2.6.1.13", "activity": "", "evidence": [ { "id": "F1MYG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG0" } ] } ] }, { "uniprot_ac": "Q3ZCF5", "gene_name": "OAT", "activity": [ { "ec_number": "2.6.1.13", "activity": "L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate.", "evidence": [ { "id": "Q3ZCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF5" } ] }, { "ec_number": "2.6.1.13", "activity": "", "evidence": [ { "id": "Q3ZCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCF5" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCF5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 439, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCF5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCF5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.6.1.13", "ec_name": "L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate.", "evidence": [ { "id": "2.6.1.13", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.13" }, { "id": "2.6.1.13", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.6.1.13" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 433, "end_pos": 435 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { 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"total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q3ZCG8-1", "uniprot_ac": "Q3ZCG8", "uniprot_id": "EMC6_BOVIN", "mass": { "chemical_mass": 12130.0, "monoisotopic_mass": 12130.0 }, "refseq": { "ac": "NP_001071503", "name": "ER membrane protein complex subunit 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071503" }, "gene_names": [ { "name": "EMC6", "type": "recommended", "evidence": [ { "id": "Q3ZCG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCG8" } ] }, { "name": "EMC6", "type": "synonym", "evidence": [ { "id": "NP_001071503", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071503" } ] }, { "name": "TMEM93", "type": "synonym", "evidence": [ { "id": "NP_001071503", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071503" }, { "id": "Q3ZCG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCG8" } ] } ], "protein_names": [ { "name": "ER membrane protein complex subunit 6", "type": "recommended", "evidence": [ { "id": "Q3ZCG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCG8/entry#names_and_taxonomy" } ] }, { "name": "ER membrane protein complex subunit 6", "type": "synonym", "evidence": [ { "id": "NP_001071503", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071503" } ] }, { "name": "Transmembrane protein 93", "type": "synonym", "evidence": [ { "id": "Q3ZCG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCG8/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 93", "type": "synonym", "evidence": [ { "id": "NP_001071503", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071503" } ] } ], "function": [ { "annotation": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCG8#function" }, { "database": "UniProtKB", "id": "Q9BV81", "url": "https://www.uniprot.org/uniprotkb/Q9BV81#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCG8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EMC6", "url": "https://www.uniprot.org/uniprotkb/Q3ZCG8", "locus": { "chromosome": "19", "start_pos": 24366614, "end_pos": 24363589, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025121", "url": "https://www.ensembl.org/id/ENSBTAG00000025121" } ] } } ], "crossref": [ { "id": "Q3ZCG8", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCG8", "database": "AlphaFoldDB", "categories": [] }, { "id": "613551", "url": "https://www.ncbi.nlm.nih.gov/gene/613551", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613551", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613551", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3ZCG8", "url": "https://www.orthodb.org/?gene=Q3ZCG8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20994", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20994", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20994:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20994:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07019", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07019", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071503", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZCG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCG8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCG8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAVVAKREGPPFISEAAVRGNAAVLDYCRTSVSALSGATAGILGLTGLYGFIFYLLASILLSLLLILKARRRWNKYFKSRRPLFTGGLIGGLFTYVLFWTFLYGMVHVY", "length": 110, "header": "sp|Q3ZCG8-1|EMC6_BOVIN Isoform 1 of ER membrane protein complex subunit 6 OS=Bos taurus OX=9913 GN=EMC6 PE=3 SV=1 CANONICAL=Q3ZCG8-1" }, "isoforms": [ { "isoform_ac": "Q3ZCG8-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCG8/entry#Q3ZCG8-1", "sequence": { "sequence": "MAAVVAKREGPPFISEAAVRGNAAVLDYCRTSVSALSGATAGILGLTGLYGFIFYLLASILLSLLLILKARRRWNKYFKSRRPLFTGGLIGGLFTYVLFWTFLYGMVHVY", "length": 110, "header": "sp|Q3ZCG8-1|EMC6_BOVIN Isoform 1 of ER membrane protein complex subunit 6 OS=Bos taurus OX=9913 GN=EMC6 PE=3 SV=1 CANONICAL=Q3ZCG8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613551", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613551", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "EMC complex", "id": "GO:0072546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072546", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCG8", "url": 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"database": "UniProtKB", "id": "Q3ZCG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCG8" } ], "pmid": "" }, { "name": "protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "id": "GO:0045050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045050", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCG8", "url": "https://www.uniprot.org/uniprotkb/Q3ZCG8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q3ZCG8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 110, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q3ZCG8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q3ZCG8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], 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The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK1#function" }, { "database": "HAMAP", "id": "MF_03011", "url": "https://hamap.expasy.org/signature/MF_03011" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF3L", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK1", "locus": { "chromosome": "5", "start_pos": 109683992, "end_pos": 109663166, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010790", "url": "https://www.ensembl.org/id/ENSBTAG00000010790" } ] } } ], "crossref": [ { "id": "Q3ZCK1", "url": "https://alphafold.ebi.ac.uk/entry/Q3ZCK1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010790", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010790", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514449", "url": "https://www.ncbi.nlm.nih.gov/gene/514449", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019382", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019382", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514449", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514449", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AGWFIRN", "url": "https://omabrowser.org/oma/group/AGWFIRN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q3ZCK1", "url": "https://www.orthodb.org/?gene=Q3ZCK1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13242", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13242", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13242:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13242:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10255", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10255", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030373", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q3ZCK1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3ZCK1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSYPADDYESEAAYDPYAYPGDYDMHTGDPKQDLAYERQYEQQTYQVIPEVIKNFIQYFHKTVSDLIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAETIAPQVGNDAVFLILYKELYYRHIYAKVSGGPSLEQRFESYYNYCNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVLNVLHSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKKSMYSRVPECQVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMINKQNEQMHALLAIALTMYPMRIDESIHLQLREKYGDKMLRMQKGDPQVYEELFSYSCPKFLSPVVPNYDNVHPNYHKEPFLQQLKVFSDEVQQQAQLSTIRSFLKLYTTMPVAKLAGFLDLTEQEFRIQLLVFKHKMKNLVWTSGISALDGEFQSASEVDFYIDKDMIHIADTKVARRYGDFFIRQIHKFEELNRTLKKMGQRP", "length": 564, "header": "sp|Q3ZCK1-1|EIF3L_BOVIN Isoform 1 of Eukaryotic translation initiation factor 3 subunit L OS=Bos taurus OX=9913 GN=EIF3L PE=2 SV=1 CANONICAL=Q3ZCK1-1" }, "isoforms": [ { "isoform_ac": "Q3ZCK1-1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK1/entry#Q3ZCK1-1", "sequence": { "sequence": "MSYPADDYESEAAYDPYAYPGDYDMHTGDPKQDLAYERQYEQQTYQVIPEVIKNFIQYFHKTVSDLIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAETIAPQVGNDAVFLILYKELYYRHIYAKVSGGPSLEQRFESYYNYCNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVLNVLHSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKKSMYSRVPECQVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMINKQNEQMHALLAIALTMYPMRIDESIHLQLREKYGDKMLRMQKGDPQVYEELFSYSCPKFLSPVVPNYDNVHPNYHKEPFLQQLKVFSDEVQQQAQLSTIRSFLKLYTTMPVAKLAGFLDLTEQEFRIQLLVFKHKMKNLVWTSGISALDGEFQSASEVDFYIDKDMIHIADTKVARRYGDFFIRQIHKFEELNRTLKKMGQRP", "length": 564, "header": "sp|Q3ZCK1-1|EIF3L_BOVIN Isoform 1 of Eukaryotic translation initiation factor 3 subunit L OS=Bos taurus OX=9913 GN=EIF3L PE=2 SV=1 CANONICAL=Q3ZCK1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514449", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514449", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-72649", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "resource": "Reactome", "description": "Translation initiation complex formation" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "resource": "Reactome", "description": "Formation of the ternary complex, and subsequently, the 43S complex" }, { "id": "R-BTA-72702", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72702", "resource": "Reactome", "description": "Ribosomal scanning and start codon recognition" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MQ91-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit L", "gene_name": "Eif3l", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSYPADDYESEAAYDPYAYPGDYDMHTGDPKQDLAYERQYEQQTYQVIPEVIKNFIQYFHKTVSDLIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAEAIAPQVGNDAVFLILYKELYYRHIYAKVSGGPSLEQRFESYYNYCNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVLNVLHSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKKSMYSRVPECQVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMINKQNEQMHALLAIALTMYPMRIDESIHLQLREKYGDKMLRMQKGDPQVYEELFSYACPKFLSPVVPNYDNVHPNYHKEPFLQQLKVFSDEVQQQAQLSTIRSFLKLYTTMPVAKLAGFLDLTEQEFRIQLLVFKHKMKNLVWTSGISALDGEFQSASEVDFYIDKDMIHIADTKVARRYGDFFIRQIHKFEELNRTLKKMGQRP", "length": 564 }, "evidence": [ { "id": "Q3ZCK1", "url": "https://omabrowser.org/oma/group/Q3ZCK1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F4JY76-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit L", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MASSNEYEEGPGERESGYDPNMVPDSVKSFVSHMYRHIRDKNVYEIHQMCETSFQSISERLFKDTPWPSVEAIAPYVDNDHVFCLLYREMWFRHLYARLSPTLKQRIDSYDNYCSLFQVVLHGVVNMQLPNQWLWDMVDEFVYQFQSFCQFRAKLKNKTEEEIALLRQHDKAWNVYGVLNFLQALVEKSCIIQILEHDKDGLEFTETDGYDFSGGSNVLKVLGYFSMVGLLRVHCLLGDYHTALKWLQPIDITQPGVYTSVIGCHIATIYHYGFATLMLRRYVDAVREFNKILLYIFKTKQYHQKSPQYEQLLKKNEQMYALLALSLSLCPQTKLVDESVNSQLRDKYGEKMMRMLRSDDEAFGIYDELFSYACPKFITPSAPPTFEEPLVNYNQDAYRLQLKMFLYEVKQQQLLSGVRTFLKVYSSISLAKLANYMEVDEPTLRTILLTYKHKTHSVDSDGRIISNADIDFFINNDMIYVVESKPAKRYGDFFLRQIAKLEGVINDMDRVKLE", "length": 514 }, "evidence": [ { "id": "Q3ZCK1", "url": "https://omabrowser.org/oma/group/Q3ZCK1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "G3V7G9-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit L", "gene_name": "Eif3l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSYPADDYESETAYDPYAYPGDYDMHTGDPKQDLAYERQYEQQTYQVIPEVIKNFIQYFHKTVSDLIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAEAIAPQVGNDAVFLILYKELYYRHIYAKVSGGPSLEQRFESYYNYCNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVLNVLHSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKKSMYSRVPECQVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMINKQNEQMHALLAIALTMYPMRIDESIHLQLREKYGDKMLRMQKGDPQVYEELFSYACPKFLSPVVPNYDNVHPNYHKEPFLQQLKVFSDEVQQQAQLSTIRSFLKLYTTMPVAKLAGFLDLTEQEFRIQLLVFKHKMKNLVWTSGISALDGEFQSASEVDFYIDKDMIHIADTKVARRYGDFFIRQIHKFEELNRTLKKMGQRP", "length": 564 }, "evidence": [ { "id": "Q3ZCK1", "url": "https://omabrowser.org/oma/group/Q3ZCK1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5F428-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit L", "gene_name": "EIF3L", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAYPGEDYDNDAAYDPYAYSNDYDMHTGDPKQDLAYERQYEQQTYQVIPEVIKNFIQYFHKTVSDLIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAEAIAPQVGNDAVFLILYKELYYRHIYAKVSGGPTLEQRFESYYNYCNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVLNVLHSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKKSMYSRVPECQVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMINKQNEQMHALLAIALTMYPMRIDESIHLQLREKYGDKMLRMQKGDAQVYEELFSYACPKFLSPVVPNYDNVHPNYHKEPFLQQLKVFADEVQQQAQLSTIRSFLKLYTTMPVAKLAGFLDLTEQEFRIQLLVFKHKMKNLVWTSGISALDGEFQSASEVDFYIDKDMIHIADTKVARRYGDFFIRQIHKFEELNRTLKKMGQRP", "length": 564 }, "evidence": [ { "id": "Q3ZCK1", "url": "https://omabrowser.org/oma/group/Q3ZCK1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q7T2A5-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit L", "gene_name": "eif3l", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSYPAEEEDVNYDPYSYPNDYDYHTGDPKADLAYERQYEHQQTYHVIPEVIKNFLQYFHKTISDLIDQKVYELQANRVSSESIEQKIYEIQDVYENSWNKLTDRFFKTSPWPEAEAIASLVGNDAVFLILYKELYYRHIYAKVSGGPTLDQRFESYYNYCNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIEFLRNNPKIWNVHSVLNVLHSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKKSMYSRVPECQITTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTRNMFQRTTYKYEMINKQNEQMHGLLAIALTMYPMRIDESIHTQLREKYGDKMLRMQKGDLQVFEELFSFACPKFLSPVVPNYENVHPNYHKEPFQQQLKVFAEEVQQQAQLSTIRSFLKLYTTMPVAKLAGFLDMSEQEFRIQLLVFKHKMKNLVWTSGISALDGEFQSASEVDFYIDKDMIHIADTKVARRYGDFFIRQIHKFEELNRTLKKMPLNTGASISSSSTSRAT", "length": 576 }, "evidence": [ { "id": "Q3ZCK1", "url": "https://omabrowser.org/oma/group/Q3ZCK1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q86LA2-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit L", "gene_name": "eif3L", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSQTNNAGTTNTNTNQNNNRKGGNNKNYQNRNNNNQQQQGGQQQQQQQHRNKHQNQQGNQNQQGNQQGGGNQQQNKQGGHRGGKTPSNVESFPINLSQQQVQQLQAYQQQTQQNQSAQFQSNFLPPATALYTPVINYFINLYNNFKSQSHQDILVSYDSFFKSCETYYPHCALPTIENLIPILGDKFEESSFTDRFFVLLYKEIYYRYYYALVFQPNINTCVESWQNYYQIFHTLLSANSPNDVEIDLPNAWLWDLVDEFVYQYHTFAKFKLKKQDVDFLSENPEIWDTTNVIRYLYYIIKKSQIFSANTNRFESSSEDFCSHPVYKMLGYYSVISLVRVQCLLGDYTLALKTLELIDMGKKAMYTYVTACHITLYYYLGFAYLMSRKYNEATKALNTILVSVASKSKSQNFQSDHNEKKTDKMYALLTICQALYPNKIDENVSNNLKEKFGDKLLRLQKGDLSVYEELYTFAAPRCIGPVPPYISGFNVTALDPHRLQLSLFLEEVKQQSLLTTIRSYITLYSTISIQKLAGLLQIDPEDLRVKLTCYKHKLFNVLGKGETKWNNQLDIDFYIDQDMIHIDNRLYAKETDSFINSILKFEGSLTPSYNWM", "length": 611 }, "evidence": [ { "id": "Q3ZCK1", "url": "https://omabrowser.org/oma/group/Q3ZCK1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8QZY1-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit L", "gene_name": "Eif3l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSYPADDYESEAAYDPYAYPGDYDMHTGDPKQDLAYERQYEQQTYQVIPEVIKNFIQYFHKTVSDLIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAEAIAPQVGNDAVFLILYKELYYRHIYAKVSGGPSLEQRFESYYNYCNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQSFSQYRCKTAKKSEGEMDFLRSNPKVWNVHSVLNVLHSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKKSMYSRVPECQVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMINKQNEQMHALLAIALTMYPMRIDESIHLQLREKYGDKMLRMQKGDPQVYEELFSYACPKFLSPVVPNYDNVHPNYHKEPFLQQLKVFSDEVQQQAQLSTIRSFLKLYTTMPVAKLAGFLDLTEQEFRIQLLVFKHKMKNLVWTSGISALDGEFQSASEVDFYIDKDMIHIADTKVARRYGDFFIRQIHKFEELNRTLKKMGQRP", "length": 564 }, "evidence": [ { "id": "Q3ZCK1", "url": "https://omabrowser.org/oma/group/Q3ZCK1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VTU4-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit L", "gene_name": "eIF3l", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MYGGDEYATNSDYYDDYAHTGDPQLDMEYERNYYAARMPDNVKYFLINFCQAIKEGNLYDIQNMYENTFPQISDHHFDKTAWPEEQEVAAIVDNDKVFLILYKELYYRHIHARIPGGPKLEQRINSFFNYCDFFNLIISAQNPVMLELPDIWLWELVDEFVYQFQNFAQYRARLTEKSQDEIQQLCVNHSNEWSILCILNVLHSLVDISNIKKQLEAISQGVDPQTVAGDFGKLSFYKMLGYFSLVGLLRVHSLLGDYYQAIKVLEPIEIHKKSAYSHIPACQISTSYYVGFAYMMMRRYADAIRTFSDILLYIQRTKQLYSTRSYQNDQINKQAEQMYHLLAICLVLHPQCIDESIQQVLREKNYHDAMFKMQCGDLEVFKSFFVFACPRFVSPCPPAVDAPMDDYVKDPMEHQLQVFMDEVRQQKDLPTTRSYLKLYTTLPLTKLASFIDPNASEDDVSKLLIRLLCFKHKMRNLVWSKGPSGLEGTFKSGSELDFYIDDDMIHIADTKVSHRYGDFFVRKILKFNDLNRKLKNINI", "length": 539 }, "evidence": [ { "id": "Q3ZCK1", "url": "https://omabrowser.org/oma/group/Q3ZCK1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y262-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit L", "gene_name": "EIF3L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSYPADDYESEAAYDPYAYPSDYDMHTGDPKQDLAYERQYEQQTYQVIPEVIKNFIQYFHKTVSDLIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAEAIAPQVGNDAVFLILYKELYYRHIYAKVSGGPSLEQRFESYYNYCNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVLNVLHSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKKSMYSRVPECQVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMINKQNEQMHALLAIALTMYPMRIDESIHLQLREKYGDKMLRMQKGDPQVYEELFSYSCPKFLSPVVPNYDNVHPNYHKEPFLQQLKVFSDEVQQQAQLSTIRSFLKLYTTMPVAKLAGFLDLTEQEFRIQLLVFKHKMKNLVWTSGISALDGEFQSASEVDFYIDKDMIHIADTKVARRYGDFFIRQIHKFEELNRTLKKMGQRP", "length": 564 }, "evidence": [ { "id": "Q3ZCK1", "url": "https://omabrowser.org/oma/group/Q3ZCK1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK1" } ], "pmid": "" }, { "name": "eukaryotic 43S preinitiation complex", "id": "GO:0016282", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016282", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK1" } ], "pmid": "" }, { "name": "eukaryotic 48S preinitiation complex", "id": "GO:0033290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033290", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK1" } ], "pmid": "" }, { "name": "eukaryotic translation initiation factor 3 complex", "id": "GO:0005852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005852", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "translational initiation", "id": "GO:0006413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006413", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK1" } ], "pmid": "" }, { "name": "formation of cytoplasmic translation initiation complex", "id": "GO:0001732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001732", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "Q3ZCK1", "url": "https://www.uniprot.org/uniprotkb/Q3ZCK1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 554, "end_pos": 556, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": 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"RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033293" } ] } ], "protein_names": [ { "name": "Serpin A3-3", "type": "recommended", "evidence": [ { "id": "Q3ZEJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZEJ6/entry#names_and_taxonomy" } ] }, { "name": "Endopin-1B", "type": "synonym", "evidence": [ { "id": "Q3ZEJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZEJ6/entry#names_and_taxonomy" } ] }, { "name": "Muscle endopin-1B", "type": "synonym", "evidence": [ { "id": "Q3ZEJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZEJ6/entry#names_and_taxonomy" } ] }, { "name": "Serpin A3-4", "type": "synonym", "evidence": [ { "id": "NP_001033293", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033293" } ] }, { "name": "endopin-1B", "type": "synonym", "evidence": [ { "id": "NP_001033293", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033293" } ] }, { "name": "mEndopin-1B", "type": "synonym", "evidence": [ { "id": "NP_001033293", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033293" }, { "id": "Q3ZEJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZEJ6/entry#names_and_taxonomy" } ] }, { "name": "muscle endopin-1B", "type": "synonym", "evidence": [ { "id": "NP_001033293", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033293" } ] }, { "name": "serpin A3-3 precursor", "type": "synonym", "evidence": [ { "id": "NP_001033293", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033293" } ] }, { "name": "serpin A3-3", "type": "synonym", "evidence": [ { "id": "NP_001033293", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033293" } ] } ], "function": [ { "annotation": "Data demonstrate the strong inhibition of human initiator and effector caspases 3 and 8 by bovine SERPINA3-1 and A3-3.", "evidence": [ { "database": 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Strongly inhibits elastase and trypsin stoichiometrically at the molar ratio of 1:1. Acts as a moderate inhibitor of plasmin and chymotrypsin. 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"16716310", "url": "https://glygen.org/publication/PubMed/16716310" } ] }, { "title": "An original SERPINA3 gene cluster: elucidation of genomic organization and gene expression in the Bos taurus 21q24 region.", "journal": "BMC Genomics", "date": "2008", "authors": "Pelissier Patrick, Delourme Didier, Germot Agnes, Blanchet Xavier, Becila Samira, Maftah Abderrahman, Leveziel Hubert, Ouali Ahmed, Bremaud Laure", "evidence": [ { "database": "UniProtKB", "id": "Q3ZEJ6", "url": "https://www.uniprot.org/uniprotkb/Q3ZEJ6" } ], "reference": [ { "type": "PubMed", "id": "18384666", "url": "https://glygen.org/publication/PubMed/18384666" } ] }, { "title": "Inhibition of human initiator caspase 8 and effector caspase 3 by cross-class inhibitory bovSERPINA3-1 and A3-3.", "journal": "FEBS letters", "date": "2009-09-03", "authors": "Herrera-Mendez Carlos H, Becila Samira, Blanchet Xavier, Pelissier Patrick, Delourme Didier, Coulis Gerald, Sentandreu Miguel A, Boudjellal Abdelghani, Bremaud Laure, Ouali Ahmed", "evidence": [ { "database": "RefSeq", "id": "NP_001033293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033293" } ], "reference": [ { "type": "PubMed", "id": "19665028", "url": "https://glygen.org/publication/PubMed/19665028" } ] }, { "title": "Mutagenesis of the bovSERPINA3-3 demonstrates the requirement of aspartate-371 for intermolecular interaction and formation of dimers.", "journal": "Protein science : a publication of the Protein Society", "date": "2012-07", "authors": "Blanchet X, P\u00e9r\u00e9-Brissaud A, Duprat N, Pinault E, Delourme D, Ouali A, Combet C, Maftah A, P\u00e9lissier P, Br\u00e9maud L", "evidence": [ { "database": "RefSeq", "id": "NP_001033293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033293" } ], "reference": [ { "type": "PubMed", "id": "22505318", "url": "https://glygen.org/publication/PubMed/22505318" } ] } ], "pathway": [ { "id": "bta:615103", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615103", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "Q3ZEJ6", "url": "https://www.uniprot.org/uniprotkb/Q3ZEJ6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q3ZEJ6", "url": "https://www.uniprot.org/uniprotkb/Q3ZEJ6" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "Q3ZEJ6", "url": "https://www.uniprot.org/uniprotkb/Q3ZEJ6" } ], "pmid": "" }, { "name": "chromaffin granule", "id": "GO:0042583", "url": 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} ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:510397", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510397", "resource": "KEGG Pathway" }, { "id": "R-BTA-375276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375276", "resource": "Reactome", "description": "Peptide ligand-binding receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "P49683-1", "protein_name": "Prolactin-releasing peptide receptor", "gene_name": "PRLHR", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q4JIJ2-1", "uniprot_ac": "Q4JIJ2", "uniprot_id": "MTRR_BOVIN", "mass": { "chemical_mass": 77163.0, "monoisotopic_mass": 77163.0 }, "refseq": { "ac": "NP_001025470", "name": "methionine synthase reductase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025470" }, "gene_names": [ { "name": "MTRR", "type": "recommended", "evidence": [ { "id": "Q4JIJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2" } ] }, { "name": "MSR", "type": "synonym", "evidence": [ { "id": "NP_001025470", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025470" } ] }, { "name": "MTRR", "type": "synonym", "evidence": [ { "id": "NP_001025470", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025470" } ] } ], "protein_names": [ { "name": "Methionine synthase reductase", "type": "recommended", "evidence": [ { "id": "Q4JIJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2/entry#names_and_taxonomy" } ] }, { "name": "1.16.1.8", "type": "synonym", "evidence": [ { "id": "Q4JIJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2/entry#names_and_taxonomy" } ] }, { "name": "AqCbl reductase", "type": "synonym", "evidence": [ { "id": "Q4JIJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2/entry#names_and_taxonomy" } ] }, { "name": "Aquacobalamin reductase", "type": "synonym", "evidence": [ { "id": "Q4JIJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2/entry#names_and_taxonomy" } ] }, { "name": "MSR", "type": "synonym", "evidence": [ { "id": "Q4JIJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2/entry#names_and_taxonomy" } ] }, { "name": "aqCbl reductase", "type": "synonym", "evidence": [ { "id": "NP_001025470", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025470" } ] }, { "name": "aquacobalamin reductase", "type": "synonym", "evidence": [ { "id": "NP_001025470", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025470" } ] }, { "name": "methionine synthase reductase", "type": "synonym", "evidence": [ { "id": "NP_001025470", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025470" } ] } ], "function": [ { "annotation": "Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin. Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (By similarity). Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance (By similarity). Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme. Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin; this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q4JIJ2", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2#function" }, { "database": "UniProtKB", "id": "Q9UBK8", "url": "https://www.uniprot.org/uniprotkb/Q9UBK8#function" }, { "database": "UniProtKB", "id": "Q8C1A3", "url": "https://www.uniprot.org/uniprotkb/Q8C1A3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q4JIJ2", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MTRR", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2", "locus": { "chromosome": "20", "start_pos": 65311477, "end_pos": 65340840, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009401", "url": "https://www.ensembl.org/id/ENSBTAG00000009401" } ] } } ], "crossref": [ { "id": "Q4JIJ2", "url": "https://alphafold.ebi.ac.uk/entry/Q4JIJ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06203", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06203", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507991", "url": "https://www.ncbi.nlm.nih.gov/gene/507991", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001094", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001094", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001709", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017927", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017927", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023173", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023173", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039261", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039261", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507991", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507991", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q4JIJ2", "url": "https://www.orthodb.org/?gene=Q4JIJ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19384", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19384", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19384:SF84", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19384:SF84", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00175", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00175", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00258", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00258", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00667", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00667", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001025470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025470", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "20752", "url": "https://www.rhea-db.org/rhea/20752", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "23908", "url": "https://www.rhea-db.org/rhea/23908", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q4JIJ2", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q4JIJ2-1", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRFLLLYATQRGQAKAIAEEISEKAVTYGFSADLHCISESDKYDLKTETAPLVMVVSTTGNGDPPDTARKFVKAIKDKTLPPDFLAHLRYGLLGLGDSEYTYFCNGGKVIDKRLQELGAQRFYDTGHADDCVGLELVVEPWINGLWAALEKHFLSNRGREDTSETLTMASHASRDAVTPELLHVESQVGLLKLDDSGGKAAKVLEQNAVNSNQSSTLIVDFEASLTHSVPPLSQASLNIPSLPPEYLEVHLEEALGQEESHASVSLVDPVFHVPVSKAVQLTTNDAIKTTLLIELDISKTDFSYQPGDAFNVICPNSDSEVQFLLQRLQLADRREHHVAVTIKADTRKKGAALPQHVPERCSLQFLLTWCLEIRAVPKKAFLRALADHTGDSAERRRLQELCSRQGAADYTRFVREAGACLSDLLRAFPSCQPPLGLLLEHLPKLQPRPYSCASSSLFHPGKLHFIFNIVEFLSNTTEVILRRGVCTGWLATLVESILQPYMCANHVDGKKALAPKISISPRTTNSFHLPDDPSVPIIMVGPGAGVAPFIGFLQHREKLQEQHPGGHFGATWLFFGCRHKERDYLFRDELRHFLKCGVLTHLEVSFSRDVAVGEEEGPAKYVQDSLQRHSKQVAGVLLQDSGYVYVCGDAKNMAKDVHDALVEIISRETGVEKLEAMKTLATLKEEKRYLQDIW", "length": 695, "header": "sp|Q4JIJ2-1|MTRR_BOVIN Isoform 1 of Methionine synthase reductase OS=Bos taurus OX=9913 GN=MTRR PE=2 SV=1 CANONICAL=Q4JIJ2-1" }, "isoforms": [ { "isoform_ac": "Q4JIJ2-1", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2/entry#Q4JIJ2-1", "sequence": { "sequence": "MRRFLLLYATQRGQAKAIAEEISEKAVTYGFSADLHCISESDKYDLKTETAPLVMVVSTTGNGDPPDTARKFVKAIKDKTLPPDFLAHLRYGLLGLGDSEYTYFCNGGKVIDKRLQELGAQRFYDTGHADDCVGLELVVEPWINGLWAALEKHFLSNRGREDTSETLTMASHASRDAVTPELLHVESQVGLLKLDDSGGKAAKVLEQNAVNSNQSSTLIVDFEASLTHSVPPLSQASLNIPSLPPEYLEVHLEEALGQEESHASVSLVDPVFHVPVSKAVQLTTNDAIKTTLLIELDISKTDFSYQPGDAFNVICPNSDSEVQFLLQRLQLADRREHHVAVTIKADTRKKGAALPQHVPERCSLQFLLTWCLEIRAVPKKAFLRALADHTGDSAERRRLQELCSRQGAADYTRFVREAGACLSDLLRAFPSCQPPLGLLLEHLPKLQPRPYSCASSSLFHPGKLHFIFNIVEFLSNTTEVILRRGVCTGWLATLVESILQPYMCANHVDGKKALAPKISISPRTTNSFHLPDDPSVPIIMVGPGAGVAPFIGFLQHREKLQEQHPGGHFGATWLFFGCRHKERDYLFRDELRHFLKCGVLTHLEVSFSRDVAVGEEEGPAKYVQDSLQRHSKQVAGVLLQDSGYVYVCGDAKNMAKDVHDALVEIISRETGVEKLEAMKTLATLKEEKRYLQDIW", "length": 695, "header": "sp|Q4JIJ2-1|MTRR_BOVIN Isoform 1 of Methionine synthase reductase OS=Bos taurus OX=9913 GN=MTRR PE=2 SV=1 CANONICAL=Q4JIJ2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 171, "end_pos": 171, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q4JIJ2", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2" } ], "site_lbl": "Ser171" }, { "start_pos": 187, "end_pos": 187, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q4JIJ2", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2" } ], "site_lbl": "Ser187" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:507991", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507991", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q4JIJ2", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "flavin adenine dinucleotide binding", "id": "GO:0050660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050660", "evidence": [ { "database": "UniProtKB", "id": "Q4JIJ2", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2" } ], "pmid": "" }, { "name": "FMN binding", "id": "GO:0010181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010181", "evidence": [ { "database": "UniProtKB", "id": "Q4JIJ2", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor", "id": "GO:0016723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016723", "evidence": [ { "database": "UniProtKB", "id": "Q4JIJ2", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2" } ], "pmid": "" }, { "name": "[methionine synthase] reductase (NADPH) activity", "id": "GO:0030586", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030586", "evidence": [ { "database": "UniProtKB", "id": "Q4JIJ2", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cobalamin metabolic process", "id": "GO:0009235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009235", "evidence": [ { "database": "UniProtKB", "id": "Q4JIJ2", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2" } ], "pmid": "" }, { "name": "folic acid metabolic process", "id": "GO:0046655", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046655", "evidence": [ { "database": "UniProtKB", "id": "Q4JIJ2", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2" } ], "pmid": "" }, { "name": "methionine biosynthetic process", "id": "GO:0009086", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009086", "evidence": [ { "database": "UniProtKB", "id": "Q4JIJ2", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2" } ], "pmid": "" }, { "name": "homocysteine metabolic process", "id": "GO:0050667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050667", "evidence": [ { "database": "UniProtKB", "id": "Q4JIJ2", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 213, "end_pos": 215, "annotation": "n_glycosylation_sequon" }, { "start_pos": 476, "end_pos": 478, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20752", "name": "", "equation": "2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q4JIJ2-1", "F1MGP5-1" ], "evidence": [ { "id": "20752", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20752" } ] }, { "id": "23908", "name": "", "equation": "2 methylcob(III)alamin-[methionine synthase] + 2 S-adenosyl-L-homocysteine + NADP(+) + H(+) = 2 cob(II)alamin-[methionine synthase] + 2 S-adenosyl-L-methionine + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q4JIJ2-1" ], "evidence": [ { "id": "23908", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23908" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MGP5", "gene_name": "MTRR", "activity": [ { "ec_number": "1.16.1.8", "activity": "2 methylcob(III)alamin-[methionine synthase] + 2 S-adenosyl-L-homocysteine + NADP(+) + H(+) = 2 cob(II)alamin-[methionine synthase] + 2 S-adenosyl-L-methionine + NADPH.", "evidence": [ { "id": "F1MGP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGP5" } ] }, { "ec_number": "1.16.1.8", "activity": "", "evidence": [ { "id": "F1MGP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGP5" } ] } ] }, { "uniprot_ac": "Q4JIJ2", "gene_name": "MTRR", "activity": [ { "ec_number": "1.16.1.8", "activity": "2 methylcob(III)alamin-[methionine synthase] + 2 S-adenosyl-L-homocysteine + NADP(+) + H(+) = 2 cob(II)alamin-[methionine synthase] + 2 S-adenosyl-L-methionine + NADPH.", "evidence": [ { "id": "Q4JIJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2" } ] }, { "ec_number": "1.16.1.8", "activity": "", "evidence": [ { "id": "Q4JIJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q4JIJ2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 695, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q4JIJ2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q4JIJ2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q4JIJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2" }, { "id": "PRU00716", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00716" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAD-binding FR-type", "eco_id": "ECO_0000255", "start_pos": 269, "end_pos": 531, "start_aa": "Asp", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q4JIJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4JIJ2" }, { "id": "PRU00088", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00088" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Flavodoxin-like", "eco_id": "ECO_0000255", "start_pos": 4, "end_pos": 147, "start_aa": "Phe", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.16.1.8", "ec_name": "2 methylcob(III)alamin-[methionine synthase] + 2 S-adenosyl-L-homocysteine + NADP(+) + H(+) = 2 cob(II)alamin-[methionine synthase] + 2 S-adenosyl-L-methionine + NADPH.", "evidence": [ { "id": "1.16.1.8", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.8" }, { "id": "1.16.1.8", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.16.1.8" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 171, 187 ], "sequon_annotation_sites": [ { "start_pos": 213, "end_pos": 215 }, { "start_pos": 476, "end_pos": 478 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", 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"start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q4LAL6-1", "uniprot_ac": "Q4LAL6", "uniprot_id": "ALX4_BOVIN", "mass": { "chemical_mass": 42484.0, "monoisotopic_mass": 42484.0 }, "refseq": { "ac": "NP_001025475", "name": "homeobox protein aristaless-like 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025475" }, "gene_names": [ { "name": "ALX4", "type": "recommended", "evidence": [ { "id": "Q4LAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4LAL6" } ] }, { "name": "ALX4", "type": "synonym", "evidence": [ { "id": "NP_001025475", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025475" } ] } ], "protein_names": [ { "name": "Homeobox protein aristaless-like 4", "type": "recommended", "evidence": [ { "id": "Q4LAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4LAL6/entry#names_and_taxonomy" } ] }, { "name": "aristaless-like homeobox 4", "type": "synonym", "evidence": [ { "id": "NP_001025475", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025475" } ] }, { "name": "homeobox protein aristaless-like 4", "type": "synonym", "evidence": [ { "id": "NP_001025475", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025475" } ] } ], "function": [ { "annotation": "The cloning, genomic structure & expression of ALX4is reported. It has 4 four exons & is on BTA15q28-->q29. Its mRNA encodes a 397-AA protein with a paired-type homeodomain & a C-terminal 'aristaless' domain. It is not involved in syndactyly.", "evidence": [ { "database": "RefSeq", "id": "NP_001025475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025475" }, { "database": "PubMed", "id": "17065792", "url": "https://glygen.org/publication/PubMed/17065792" } ] }, { "annotation": "Transcription factor involved in skull and limb development.", "evidence": [ { "database": "UniProtKB", "id": "Q4LAL6", "url": "https://www.uniprot.org/uniprotkb/Q4LAL6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q4LAL6", "url": "https://www.uniprot.org/uniprotkb/Q4LAL6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ALX4", "url": "https://www.uniprot.org/uniprotkb/Q4LAL6", "locus": { "chromosome": "15", "start_pos": 74373004, "end_pos": 74417627, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027563", "url": "https://www.ensembl.org/id/ENSBTAG00000027563" } ] } } ], "crossref": [ { "id": "Q4LAL6", "url": "https://alphafold.ebi.ac.uk/entry/Q4LAL6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "594846", "url": "https://www.ncbi.nlm.nih.gov/gene/594846", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003654", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003654", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050649", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050649", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:594846", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:594846", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q4LAL6", "url": "https://www.orthodb.org/?gene=Q4LAL6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24329", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24329", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24329:SF322", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24329:SF322", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03826", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03826", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001025475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025475", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q4LAL6", "url": "https://www.uniprot.org/uniprotkb/Q4LAL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q4LAL6-1", "url": "https://www.uniprot.org/uniprotkb/Q4LAL6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNAETCVSYCESPAAAMDAYYSPVSQSREGSSPFRAYPGGDKFSTTFLSAAAKGQGFGDAKSRARYGAGQQDPAAPLESGAGARGSFSKFQPQPPAPQPQPPAPQPHLYLQRGACKTPPDGSLKLQEGGGGHNAALQVPCYAKESSLGEPELPPDSDTVGMDSSYLSVMEAGVKGPQDRASADLPSPMEKADSESNKGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYELPLLTRAENYAQIQNPSWIGNNGAASPVPACVVPCDPVPACMSPHAHPPGSGASGVTDFLSVSGAGSHVGQTHMGSLFGAAGLSPGLNGYELNGEPDRKTSSIAALRMKAKEHSAAISWAT", "length": 397, "header": "sp|Q4LAL6-1|ALX4_BOVIN Isoform 1 of Homeobox protein aristaless-like 4 OS=Bos taurus OX=9913 GN=ALX4 PE=2 SV=1 CANONICAL=Q4LAL6-1" }, "isoforms": [ { "isoform_ac": "Q4LAL6-1", "url": "https://www.uniprot.org/uniprotkb/Q4LAL6/entry#Q4LAL6-1", "sequence": { "sequence": "MNAETCVSYCESPAAAMDAYYSPVSQSREGSSPFRAYPGGDKFSTTFLSAAAKGQGFGDAKSRARYGAGQQDPAAPLESGAGARGSFSKFQPQPPAPQPQPPAPQPHLYLQRGACKTPPDGSLKLQEGGGGHNAALQVPCYAKESSLGEPELPPDSDTVGMDSSYLSVMEAGVKGPQDRASADLPSPMEKADSESNKGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYELPLLTRAENYAQIQNPSWIGNNGAASPVPACVVPCDPVPACMSPHAHPPGSGASGVTDFLSVSGAGSHVGQTHMGSLFGAAGLSPGLNGYELNGEPDRKTSSIAALRMKAKEHSAAISWAT", "length": 397, "header": "sp|Q4LAL6-1|ALX4_BOVIN Isoform 1 of Homeobox protein aristaless-like 4 OS=Bos taurus OX=9913 GN=ALX4 PE=2 SV=1 CANONICAL=Q4LAL6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 186, "end_pos": 186, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q4LAL6", "url": "https://www.uniprot.org/uniprotkb/Q4LAL6" } ], "site_lbl": "Ser186" } ], "glycation": [], "keywords": [], "publication": [ { "title": "The bovine aristaless-like homeobox 4 (ALX4) as a candidate gene for syndactyly.", "journal": "Cytogenetic and genome research", "date": "2006", "authors": "W\u00f6hlke A, Kuiper H, Distl O, Dr\u00f6gem\u00fcller C", "evidence": [ { "database": "RefSeq", "id": "NP_001025475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025475" } ], "reference": [ { "type": "PubMed", "id": "17065792", "url": "https://glygen.org/publication/PubMed/17065792" } ] } ], "pathway": [ { "id": "bta:594846", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:594846", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q4LAL6", "url": "https://www.uniprot.org/uniprotkb/Q4LAL6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q4LAL6", "url": "https://www.uniprot.org/uniprotkb/Q4LAL6" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q4LAL6", "url": "https://www.uniprot.org/uniprotkb/Q4LAL6" } ], "pmid": "" }, { "name": "neuron development", "id": "GO:0048666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048666", "evidence": [ { "database": "UniProtKB", "id": "Q4LAL6", "url": "https://www.uniprot.org/uniprotkb/Q4LAL6" } ], "pmid": "" }, { "name": "animal organ development", "id": "GO:0048513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048513", "evidence": [ { "database": "UniProtKB", "id": "Q4LAL6", "url": "https://www.uniprot.org/uniprotkb/Q4LAL6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "Q4LAL6", "url": "https://www.uniprot.org/uniprotkb/Q4LAL6" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "Q4LAL6", "url": "https://www.uniprot.org/uniprotkb/Q4LAL6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 203, "end_pos": 205, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q4LAL6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 397, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q4LAL6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q4LAL6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q4LAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4LAL6" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Nucleotide_Binding_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000255", "start_pos": 200, "end_pos": 259, "start_aa": "Lys", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q4LAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4LAL6" }, { "id": "PRU00138", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00138" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "OAR", "eco_id": "ECO_0000255", "start_pos": 377, "end_pos": 390, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 186 ], "sequon_annotation_sites": [ { "start_pos": 203, "end_pos": 205 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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}, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q56JX8-1", "uniprot_ac": "Q56JX8", "uniprot_id": "RS13_BOVIN", "mass": { "chemical_mass": 17222.0, "monoisotopic_mass": 17222.0 }, "refseq": { "ac": "NP_001020513", "name": "small 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ribosomal subunit protein uS15", "type": "synonym", "evidence": [ { "id": "NP_001020513", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020513" } ] } ], "function": [ { "annotation": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.", "evidence": [ { "database": "UniProtKB", "id": "Q56JX8", "url": "https://www.uniprot.org/uniprotkb/Q56JX8#function" }, { "database": "UniProtKB", "id": "P62277", "url": "https://www.uniprot.org/uniprotkb/P62277#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q56JX8", "url": "https://www.uniprot.org/uniprotkb/Q56JX8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPS13", "url": "https://www.uniprot.org/uniprotkb/Q56JX8", "locus": { "chromosome": "15", "start_pos": 35411050, "end_pos": 35408334, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040308", "url": "https://www.ensembl.org/id/ENSBTAG00000040308" } ] } } ], "crossref": [ { "id": "Q56JX8", "url": "https://alphafold.ebi.ac.uk/entry/Q56JX8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040308", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040308", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00353", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00353", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535668", "url": "https://www.ncbi.nlm.nih.gov/gene/535668", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000589", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000589", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009068", "url": 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ribosomal subunit protein uS15 OS=Bos taurus OX=9913 GN=RPS13 PE=2 SV=3 CANONICAL=Q56JX8-1" }, "isoforms": [ { "isoform_ac": "Q56JX8-1", "url": "https://www.uniprot.org/uniprotkb/Q56JX8/entry#Q56JX8-1", "sequence": { "sequence": "MGRMHAPGKGLSQSALPYRRSVPTWLKLTSDDVKEQIYKLAKKGLTPSQIGVILRDSHGVAQVRFVTGNKILRILKSKGLAPDLPEDLYHLIKKAVAVRKHLERNRKDKDAKFRLILIESRIHRLARYYKTKRVLPPNWKYESSTASALVA", "length": 151, "header": "sp|Q56JX8-1|RS13_BOVIN Isoform 1 of Small ribosomal subunit protein uS15 OS=Bos taurus OX=9913 GN=RPS13 PE=2 SV=3 CANONICAL=Q56JX8-1" }, "locus": { "chromosome": "15", "start_pos": 35411007, "end_pos": 35408358, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055693.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055693.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052105.2", "url": "https://www.ensembl.org/id/ENSBTAP00000052105.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 30, "end_pos": 30, 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"https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72649", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72649", "resource": "Reactome", "description": "Translation initiation complex formation" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72695", "resource": "Reactome", "description": "Formation of the ternary complex, and subsequently, the 43S complex" }, { "id": "R-BTA-72702", "name": "", "url": 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"R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "P05756-1", "protein_name": "Small ribosomal subunit protein uS15", "gene_name": "RPS13", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MGRMHSAGKGISSSAIPYSRNAPAWFKLSSESVIEQIVKYARKGLTPSQIGVLLRDAHGVTQARVITGNKIMRILKSNGLAPEIPEDLYYLIKKAVSVRKHLERNRKDKDAKFRLILIESRIHRLARYYRTVAVLPPNWKYESATASALVN", "length": 151 }, "evidence": [ { "id": "Q56JX8", "url": "https://omabrowser.org/oma/group/Q56JX8/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P62277-1", "protein_name": "Small ribosomal subunit protein uS15", "gene_name": "RPS13", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGRMHAPGKGLSQSALPYRRSVPTWLKLTSDDVKEQIYKLAKKGLTPSQIGVILRDSHGVAQVRFVTGNKILRILKSKGLAPDLPEDLYHLIKKAVAVRKHLERNRKDKDAKFRLILIESRIHRLARYYKTKRVLPPNWKYESSTASALVA", "length": 151 }, "evidence": [ { "id": "Q56JX8", "url": "https://omabrowser.org/oma/group/Q56JX8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P62278-1", "protein_name": "Small ribosomal subunit protein uS15", "gene_name": "Rps13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGRMHAPGKGLSQSALPYRRSVPTWLKLTSDDVKEQIYKLAKKGLTPSQIGVILRDSHGVAQVRFVTGNKILRILKSKGLAPDLPEDLYHLIKKAVAVRKHLERNRKDKDAKFRLILIESRIHRLARYYKTKRVLPPNWKYESSTASALVA", "length": 151 }, "evidence": [ { "id": "Q56JX8", "url": "https://omabrowser.org/oma/group/Q56JX8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P62301-1", "protein_name": "Small ribosomal subunit protein uS15", "gene_name": "Rps13", "tax_id": 10090, "organism": "Mus 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"gene_name": "rps13", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGRMHSNGKGISGSSLPYNRKPHAWTKPTASEVCETVCKLAKRGYTPSKIGSSLRDSLGVAQVKNVTGSKILRILKVNGLAPTIPEDLYHLIKKAVTINKHLQRARKDYDGKFHLRLVESRIHRLTRPYRKNGTLAPNWKYESNNASTLVA", "length": 151 }, "evidence": [ { "id": "Q56JX8", "url": "https://omabrowser.org/oma/group/Q56JX8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6ITC7-1", "protein_name": "Small ribosomal subunit protein uS15", "gene_name": "RPS13", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGRMHAPGKGLSQSALPYRRSVPTWLKLTSDDVKEQIYKLAKKGLTPSQIGVILRDSHGVAQVRFVTGNKILRILKSKGLAPDLPEDLYHLIKKAVAVRKHLERNRKDKDAKFRLILIESRIHRLARYYKTKRVLPPNWKYESSTASALVA", "length": 151 }, "evidence": [ { "id": "Q56JX8", "url": "https://omabrowser.org/oma/group/Q56JX8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { 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"uniprot_id": "FABPI_BOVIN", "mass": { "chemical_mass": 15036.0, "monoisotopic_mass": 15036.0 }, "refseq": { "ac": "NP_001020503", "name": "fatty acid-binding protein, intestinal", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020503" }, "gene_names": [ { "name": "FABP2", "type": "recommended", "evidence": [ { "id": "Q56JX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JX9" } ] }, { "name": "FABP2", "type": "synonym", "evidence": [ { "id": "NP_001020503", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020503" } ] }, { "name": "FABPI", "type": "synonym", "evidence": [ { "id": "Q56JX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JX9" } ] } ], "protein_names": [ { "name": "Fatty acid-binding protein, intestinal", "type": "recommended", "evidence": [ { "id": "Q56JX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JX9/entry#names_and_taxonomy" } ] }, { "name": "FABPI", "type": "synonym", "evidence": [ { "id": "NP_001020503", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020503" } ] }, { "name": "Fatty acid-binding protein 2", "type": "synonym", "evidence": [ { "id": "Q56JX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JX9/entry#names_and_taxonomy" } ] }, { "name": "I-FABP", "type": "synonym", "evidence": [ { "id": "NP_001020503", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020503" }, { "id": "Q56JX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JX9/entry#names_and_taxonomy" } ] }, { "name": "Intestinal-type fatty acid-binding protein", "type": "synonym", "evidence": [ { "id": "Q56JX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JX9/entry#names_and_taxonomy" } ] }, { "name": "fatty acid binding protein 2, intestinal", "type": "synonym", "evidence": [ { "id": "NP_001020503", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020503" } ] }, { "name": "fatty acid-binding protein, intestinal", "type": "synonym", "evidence": [ { "id": "NP_001020503", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020503" } ] }, { "name": "intestinal-type fatty acid-binding protein", "type": "synonym", "evidence": [ { "id": "NP_001020503", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020503" } ] } ], "function": [ { "annotation": "FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q56JX9", "url": "https://www.uniprot.org/uniprotkb/Q56JX9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q56JX9", "url": "https://www.uniprot.org/uniprotkb/Q56JX9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FABP2", "url": "https://www.uniprot.org/uniprotkb/Q56JX9", "locus": { "chromosome": "6", "start_pos": 5966720, "end_pos": 5973558, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017045", "url": "https://www.ensembl.org/id/ENSBTAG00000017045" } ] } } ], "crossref": [ { "id": "Q56JX9", "url": "https://alphafold.ebi.ac.uk/entry/Q56JX9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd19445", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19445", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515768", "url": "https://www.ncbi.nlm.nih.gov/gene/515768", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000463", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000463", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000566", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000566", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031272", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031272", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515768", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515768", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q56JX9", "url": "https://www.orthodb.org/?gene=Q56JX9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11955", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11955", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00061", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00061", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001020503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020503", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q56JX9", "url": "https://www.uniprot.org/uniprotkb/Q56JX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q56JX9-1", "url": "https://www.uniprot.org/uniprotkb/Q56JX9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFDGTWKVDRNENYEKFMEKMGINVVKRKLAAHDNLKLIITQEGNKFTVKESSTFRSIEIIFELGVTFNYSLADGTELSGAWALEGDKLVGKFKRLDNGNALNTVREIIGGEMVQTYTYEGVEAKRIFKKE", "length": 132, "header": "sp|Q56JX9-1|FABPI_BOVIN Isoform 1 of Fatty acid-binding protein, intestinal OS=Bos taurus OX=9913 GN=FABP2 PE=2 SV=3 CANONICAL=Q56JX9-1" }, "isoforms": [ { "isoform_ac": "Q56JX9-1", "url": "https://www.uniprot.org/uniprotkb/Q56JX9/entry#Q56JX9-1", "sequence": { "sequence": "MAFDGTWKVDRNENYEKFMEKMGINVVKRKLAAHDNLKLIITQEGNKFTVKESSTFRSIEIIFELGVTFNYSLADGTELSGAWALEGDKLVGKFKRLDNGNALNTVREIIGGEMVQTYTYEGVEAKRIFKKE", "length": 132, "header": "sp|Q56JX9-1|FABPI_BOVIN Isoform 1 of Fatty acid-binding protein, intestinal OS=Bos taurus OX=9913 GN=FABP2 PE=2 SV=3 CANONICAL=Q56JX9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515768", "name": "", "url": 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"go_terms": [ { "name": "fatty acid transport", "id": "GO:0015908", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015908", "evidence": [ { "database": "UniProtKB", "id": "Q56JX9", "url": "https://www.uniprot.org/uniprotkb/Q56JX9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q56JX9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 132, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q56JX9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q56JX9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { 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The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B4 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. 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"Rattus norvegicus", "sequence": { "sequence": "MTDRYTIHSQLEHLQSKYIGTGHADTTKWEWLVNQHRDSYCSYMGHFDLLNYFAIAENESKARVRFNLMEKMLQPSGPPADKPEEN", "length": 86 }, "evidence": [ { "id": "Q56K13", "url": "https://omabrowser.org/oma/group/Q56K13/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H6X4-1", "protein_name": "Splicing factor 3B subunit 5", "gene_name": "Sf3b5", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTDRYTIHSQLEHLQSKYIGTGHADTTKWEWLVNQHRDSYCSYMGHFDLLNYFAIAENESKARVRFNLMEKMLQPSGPPADKPEEN", "length": 86 }, "evidence": [ { "id": "Q56K13", "url": "https://omabrowser.org/oma/group/Q56K13/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P58728-1", "protein_name": "Uncharacterized protein At4g14342", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": 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"phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58CR3-1", "uniprot_ac": "Q58CR3", "uniprot_id": "EIF2D_BOVIN", "mass": { "chemical_mass": 63647.0, "monoisotopic_mass": 63647.0 }, "refseq": { "ac": "NP_001030276", "name": "eukaryotic translation initiation factor 2D", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030276" }, "gene_names": [ { "name": "EIF2D", "type": "recommended", "evidence": [ { "id": "Q58CR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CR3" } ] }, { "name": "EIF2D", "type": "synonym", "evidence": [ { "id": "NP_001030276", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030276" } ] }, { "name": "LGTN", "type": "synonym", "evidence": [ { "id": "NP_001030276", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030276" }, { "id": "Q58CR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CR3" } ] } ], "protein_names": [ { "name": "Eukaryotic translation initiation factor 2D", "type": "recommended", "evidence": [ { "id": "Q58CR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CR3/entry#names_and_taxonomy" } ] }, { "name": "Ligatin", "type": "synonym", "evidence": [ { "id": "Q58CR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CR3/entry#names_and_taxonomy" } ] }, { "name": "eIF2d", "type": "synonym", "evidence": [ { "id": "Q58CR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CR3/entry#names_and_taxonomy" } ] }, { "name": "eukaryotic translation initiation factor 2D", "type": "synonym", "evidence": [ { "id": "NP_001030276", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030276" } ] }, { "name": "ligatin", "type": "synonym", "evidence": [ { "id": "NP_001030276", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030276" } ] } ], "function": [ { "annotation": "Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q58CR3", "url": "https://www.uniprot.org/uniprotkb/Q58CR3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CR3", "url": "https://www.uniprot.org/uniprotkb/Q58CR3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF2D", "url": "https://www.uniprot.org/uniprotkb/Q58CR3", "locus": { "chromosome": "16", "start_pos": 4369660, "end_pos": 4391597, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010432", "url": "https://www.ensembl.org/id/ENSBTAG00000010432" } ] } } ], "crossref": [ { "id": "Q58CR3", "url": "https://alphafold.ebi.ac.uk/entry/Q58CR3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd11608", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11608", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11610", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11610", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21156", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21156", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511844", "url": "https://www.ncbi.nlm.nih.gov/gene/511844", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001950", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001950", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002478", "database": 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"https://www.ebi.ac.uk/interpro/entry/IPR041366", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048248", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048248", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057429", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057429", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058886", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058886", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511844", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511844", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58CR3", "url": "https://www.orthodb.org/?gene=Q58CR3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12217", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12217", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12217:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12217:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01253", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01253", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17832", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17832", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25304", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25304", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26291", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26291", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26292", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26292", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030276", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58CR3", "url": "https://www.uniprot.org/uniprotkb/Q58CR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CR3-1", "url": "https://www.uniprot.org/uniprotkb/Q58CR3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFAKAFRVKSNTAIKGSDRRKLRADVAAVFPTLGTDQVSELVPGKEELNIVKLYAHRGDAVTVYVSGGNPILFELEKNLYPTVYTLWSYPDLLPTFTTWPLVLEKLVGGADLMLPGLVVPPAGLPQVQKGDLCAVALVGNRAPVAVGVAAMSTAEMLASGLKGRGFCVLHSYQDHLWRSGDKSSPPSIAPLALNPPDLSEGKGCVKADTALQGAMRQLTLEEEVQQRCEEKSPSEATEDPGPGGLHVDPMDSKTLQEQMDELLQTCFLHALKCSVRKADLPLLTSTLLGSHMFSCCPEGRQLDIKKSSYKKLSKFLQHMQQEQIIQVQELSKGVESIVAVDWKHPRITSFVIPEPSPTSQTIQEGSREQPYHPPDIKPLYCVPASMTLLFQESGHKKGSVLEGSEVRTFVINYAKKNDLVDADNKNLVKLDPILCDCILEKDEQHTVTKLPWDSLLGRCLEKLQPAYQVTFPGQEPIVKKGRICPIDITLAQKASNKKVTVVRNLEAYGLDPRSVAATLQQRCQASTTVTSAPGLKDSVQVQIQGNQIHHLGRLLLEEYRLPRKHIQGLEKAPKPGKKK", "length": 579, "header": "sp|Q58CR3-1|EIF2D_BOVIN Isoform 1 of Eukaryotic translation initiation factor 2D OS=Bos taurus OX=9913 GN=EIF2D PE=2 SV=1 CANONICAL=Q58CR3-1" }, "isoforms": [ { "isoform_ac": "Q58CR3-1", "url": "https://www.uniprot.org/uniprotkb/Q58CR3/entry#Q58CR3-1", "sequence": { "sequence": "MFAKAFRVKSNTAIKGSDRRKLRADVAAVFPTLGTDQVSELVPGKEELNIVKLYAHRGDAVTVYVSGGNPILFELEKNLYPTVYTLWSYPDLLPTFTTWPLVLEKLVGGADLMLPGLVVPPAGLPQVQKGDLCAVALVGNRAPVAVGVAAMSTAEMLASGLKGRGFCVLHSYQDHLWRSGDKSSPPSIAPLALNPPDLSEGKGCVKADTALQGAMRQLTLEEEVQQRCEEKSPSEATEDPGPGGLHVDPMDSKTLQEQMDELLQTCFLHALKCSVRKADLPLLTSTLLGSHMFSCCPEGRQLDIKKSSYKKLSKFLQHMQQEQIIQVQELSKGVESIVAVDWKHPRITSFVIPEPSPTSQTIQEGSREQPYHPPDIKPLYCVPASMTLLFQESGHKKGSVLEGSEVRTFVINYAKKNDLVDADNKNLVKLDPILCDCILEKDEQHTVTKLPWDSLLGRCLEKLQPAYQVTFPGQEPIVKKGRICPIDITLAQKASNKKVTVVRNLEAYGLDPRSVAATLQQRCQASTTVTSAPGLKDSVQVQIQGNQIHHLGRLLLEEYRLPRKHIQGLEKAPKPGKKK", "length": 579, "header": "sp|Q58CR3-1|EIF2D_BOVIN Isoform 1 of Eukaryotic translation initiation factor 2D OS=Bos taurus OX=9913 GN=EIF2D PE=2 SV=1 CANONICAL=Q58CR3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 232, "end_pos": 232, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58CR3", "url": "https://www.uniprot.org/uniprotkb/Q58CR3" } ], "site_lbl": "Ser232" }, { "start_pos": 356, "end_pos": 356, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58CR3", "url": "https://www.uniprot.org/uniprotkb/Q58CR3" } ], "site_lbl": "Ser356" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CR3", "url": "https://www.uniprot.org/uniprotkb/Q58CR3" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:511844", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511844", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q58CR3", "url": "https://www.uniprot.org/uniprotkb/Q58CR3" } ], "pmid": "" }, { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "Q58CR3", "url": "https://www.uniprot.org/uniprotkb/Q58CR3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58CR3", "url": "https://www.uniprot.org/uniprotkb/Q58CR3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "formation of translation preinitiation complex", "id": "GO:0001731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001731", "evidence": [ { "database": "UniProtKB", "id": "Q58CR3", "url": "https://www.uniprot.org/uniprotkb/Q58CR3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CR3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 579, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CR3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CR3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58CR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CR3" }, { "id": "PRU00161", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00161" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PUA", "eco_id": "ECO_0000255", "start_pos": 93, "end_pos": 173, "start_aa": "Leu", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58CR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CR3" }, { "id": "PRU00200", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00200" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SUI1", "eco_id": "ECO_0000255", "start_pos": 486, "end_pos": 559, "start_aa": "Ile", "end_aa": "Tyr", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58CR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CR3" }, { "id": "PRU01273", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01273" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SWIB/MDM2", "eco_id": "ECO_0000255", "start_pos": 378, "end_pos": 462, "start_aa": "Pro", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 232, 356 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58CX2-1", "uniprot_ac": "Q58CX2", "uniprot_id": "FAKD3_BOVIN", "mass": { "chemical_mass": 75487.0, "monoisotopic_mass": 75487.0 }, "refseq": { "ac": "NP_001019699", "name": "FAST kinase domain-containing protein 3, mitochondrial", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019699" }, "gene_names": [ { "name": "FASTKD3", "type": "recommended", "evidence": [ { "id": "Q58CX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CX2" } ] }, { "name": "FASTKD3", "type": "synonym", "evidence": [ { "id": "NP_001019699", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019699" } ] } ], "protein_names": [ { "name": "FAST kinase domain-containing protein 3, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q58CX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CX2/entry#names_and_taxonomy" } ] }, { "name": "FAST kinase domain-containing protein 3, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001019699", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019699" } ] } ], "function": [ { "annotation": "Required for normal mitochondrial respiration. Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1 mRNA translation and increases mitochondrial complex IV assembly and activity.", "evidence": [ { "database": "UniProtKB", "id": "Q58CX2", "url": "https://www.uniprot.org/uniprotkb/Q58CX2#function" }, { "database": "UniProtKB", "id": "Q14CZ7", "url": "https://www.uniprot.org/uniprotkb/Q14CZ7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CX2", "url": "https://www.uniprot.org/uniprotkb/Q58CX2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FASTKD3", "url": "https://www.uniprot.org/uniprotkb/Q58CX2", "locus": { "chromosome": "20", "start_pos": 65354970, "end_pos": 65345640, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009400", "url": "https://www.ensembl.org/id/ENSBTAG00000009400" } ] } } ], "crossref": [ { "id": "Q58CX2", "url": "https://alphafold.ebi.ac.uk/entry/Q58CX2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009400", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009400", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513260", "url": "https://www.ncbi.nlm.nih.gov/gene/513260", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010622", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010622", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013584", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013584", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513260", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513260", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VQIPYHE", "url": "https://omabrowser.org/oma/group/VQIPYHE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58CX2", "url": "https://www.orthodb.org/?gene=Q58CX2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21228", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21228", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21228:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21228:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06743", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06743", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08368", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08368", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001019699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019699", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58CX2", "url": "https://www.uniprot.org/uniprotkb/Q58CX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CX2-1", "url": "https://www.uniprot.org/uniprotkb/Q58CX2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CX2-2", "url": "https://www.uniprot.org/uniprotkb/Q58CX2-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALVTLRRNLYHLSDFRIHGALAALKTQQVNHVHKTVKEHLCPWFWSQHPGPIRVRFHHAHCKKFHSENGNDLHPVGEPGFSQVHNWDRFEHSVKNVDEQMFYRKLNSFTSSGEILRFVSTLETLPDTMMAGALHRICEVERKDGDQRLPKEILESSAFQALCDRFGRDPSDLSNAGLVTAFQALTLLCGDPQSHLLMNLEAECQHRLERGGLDVHSLCILGETLIKLHGPGCSTLDLIIYQLQGESLETFTPEDIVTVYRLLQASPEKADQQQRFLNKINHFSLSLVSNLSPKLMSQMLTALVVLDQTQALPLVIKLSKYVVRHIARFTSEELRKVLEALIYFGHSDRFFTETLEQHVASLCLTLDPELVSRVMEYCSRKLILSEPIFNAVAETFVCQAEKFSPSQTAKLIEPFGKLNYLPPNASALFRKLENMLLTRFNHFPPKTLLRLLHSCSLIESHPVNFMAKIFSPYFLQQLQGAESYLDRLSLAQLTQLFLTSILECPFYKGPKLLPKFQVKSFLTPCSSLETPMDFHLYKSVMIGLIDLLGARLYFSSKVLTPYCYTIDVEIKLDEDGFVLPFTIDEDVHKRVALCIDGPKRFCLNSKHLLGKEATKQRHLRLLGYQVVQIPYYEIEMLKSRLELVDYLQGKLFSQNSGGHW", "length": 660, "header": "sp|Q58CX2-1|FAKD3_BOVIN Isoform 1 of FAST kinase domain-containing protein 3, mitochondrial OS=Bos taurus OX=9913 GN=FASTKD3 PE=2 SV=2 CANONICAL=Q58CX2-1" }, "isoforms": [ { "isoform_ac": "Q58CX2-1", "url": "https://www.uniprot.org/uniprotkb/Q58CX2/entry#Q58CX2-1", "sequence": { "sequence": "MALVTLRRNLYHLSDFRIHGALAALKTQQVNHVHKTVKEHLCPWFWSQHPGPIRVRFHHAHCKKFHSENGNDLHPVGEPGFSQVHNWDRFEHSVKNVDEQMFYRKLNSFTSSGEILRFVSTLETLPDTMMAGALHRICEVERKDGDQRLPKEILESSAFQALCDRFGRDPSDLSNAGLVTAFQALTLLCGDPQSHLLMNLEAECQHRLERGGLDVHSLCILGETLIKLHGPGCSTLDLIIYQLQGESLETFTPEDIVTVYRLLQASPEKADQQQRFLNKINHFSLSLVSNLSPKLMSQMLTALVVLDQTQALPLVIKLSKYVVRHIARFTSEELRKVLEALIYFGHSDRFFTETLEQHVASLCLTLDPELVSRVMEYCSRKLILSEPIFNAVAETFVCQAEKFSPSQTAKLIEPFGKLNYLPPNASALFRKLENMLLTRFNHFPPKTLLRLLHSCSLIESHPVNFMAKIFSPYFLQQLQGAESYLDRLSLAQLTQLFLTSILECPFYKGPKLLPKFQVKSFLTPCSSLETPMDFHLYKSVMIGLIDLLGARLYFSSKVLTPYCYTIDVEIKLDEDGFVLPFTIDEDVHKRVALCIDGPKRFCLNSKHLLGKEATKQRHLRLLGYQVVQIPYYEIEMLKSRLELVDYLQGKLFSQNSGGHW", "length": 660, "header": "sp|Q58CX2-1|FAKD3_BOVIN Isoform 1 of FAST kinase domain-containing protein 3, mitochondrial OS=Bos taurus OX=9913 GN=FASTKD3 PE=2 SV=2 CANONICAL=Q58CX2-1" }, "locus": {} }, { "isoform_ac": "Q58CX2-2", "url": "https://www.uniprot.org/uniprotkb/Q58CX2/entry#Q58CX2-2", "sequence": { "sequence": "MALVTLRRNLYHLSDFRIHGALAALKTQQVNHVHKTVKEHLCPWFWSQHPGPIRVRFHHAHCKKFHSENGNDLHPVGEPGFSQVHNWDRFEHSVKNVDEQMFYRKLNSFTSSGEILRFVSTLETLPDTMMAGALHRICEVERKDGDQRLPKEILESSAFQALCDRFGRDPSDLSNAGLVTAFQALTLLCGDPQSHLLMNLEAECQHRLERGGLDVHSLCILGETLIKLHGPGCSTLDLIIYQLQGESLETFTPEDIVTVYRLLQASPEKADQQQRFLNKINHFSLSLVSNLSPKLMSQMLTALVVLDQTQALPLVIKLSKYVVRHIARFTSEELRKVLEALIYFGHSDRFFTETLEQHVASLCLTLDPELVSRVMEYCSRKLILSEPIFNAVAETFVCQAEKFSPSQTAKLIEPFGKLNYLPPNASALFRKLENMLLTRFNHFPPKTLLRLLLLPSIFPSIKIFSSEPVLRIKWPKYWSFSISPSHEYSRWIFLEDGLVGSPCSPRDSQEPSPTPQFESINSSVLSSLYSPTVTSRHDYWKNHSFDSMDLCQQGDVFAF", "length": 559, "header": "sp|Q58CX2-2|FAKD3_BOVIN Isoform 2 of FAST kinase domain-containing protein 3, mitochondrial OS=Bos taurus OX=9913 GN=FASTKD3 PE=2 SV=2 CANONICAL=Q58CX2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CX2", "url": "https://www.uniprot.org/uniprotkb/Q58CX2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:513260", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513260", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4IJX1-1", "protein_name": "FAST kinase domain-containing protein 3, mitochondrial isoform X1", "gene_name": "fastkd3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVTLFPMAKTLALRLRVLSLLDYQILKACAGKPLSSPFLQTYTGCFPTCSFHSARAVCTTERDPLFLASGSVRPYQELCLSGSGLSLMHYLSSNEDHAFMKRLSSCSTSQQVLHLLRSYSVLSSAVAASILHRLADLEHDAPEKSWSYLSDVAFNKLCQRLEDNSAELENEVLVGALLSCTRLYLGSRSSLVLRLVLECQKRLDSEKLNVKVLCGISRASFALEGHDSGLVKQAMSQLQKTETAQWKAAELVAVYCMLATGLAEDVLYQDLLNEMNAQALRLVHQMDPEAVSKILGALVTLRQEQALPLVIALCKQAVHQVQSFADAELTVVLSALMHFGHSDHFFVEALERYVPKVAFTAHAETITKVMQFFQHRRILSLPVFNAVAESFVYRAEEYSTWQVSQQITTLGVLGYLPPDAGRLFRKVESVLHARFSQFQPRALLDLLHACTLLQRYPLNFVSKVFSSYFLQLLQGEEGSGLSHVVLAQLTQLYMSVKLECPFYDGPRLLPKFCVKSFLAPFETPVEPQFYNALKSGLVDLLGDQSIVASRVLTPYCYTLDIEIKLDEDGFVLPACHADDVHKRIAVCIDGSQRFAANAKKLLGKEAMKQRHLRILGYEVVQIPYYEFEKLKKKKEVVEYLHKKIFPHSYRLSW", "length": 653 }, "evidence": [ { "id": "Q58CX2", "url": "https://omabrowser.org/oma/group/Q58CX2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q14CZ7-1", "protein_name": "FAST kinase domain-containing protein 3, mitochondrial", "gene_name": "FASTKD3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALITLRKNLYRLSDFQMHRALAALKNKPLNHVHKVVKERLCPWLCSRQPEPFGVKFHHAHCKKFHSKNGNDLHPLGGPVFSQVSDCDRLEQNVKNEESQMFYRRLSNLTSSEEVLSFISTMETLPDTMAAGALQRICEVEKKDGDQGLPKEILENSIFQALCFQFEKEPSQLSNTSLVTALQALILLHVDPQSSLLLNLVAECQNRLRKGGMEVRNLCILGESLITLHSSGCVTLELIINQLQGEKLETFTPEDIVALYRILQACTEKVDEHQTFLNKINNFSLSIVSNLSPKLISQMLTALVVLDQSQAFPLIIKLGKYVVRHVPHFTNEELRRVLEAFIYFGHHDTFFTKALEHRVAAVCLTLDPEVVCRVMEYCSRELILSKPILNAVAETFVCQTEKFSPRQISALMEPFGKLNYLPPNASALFRKLENVLFTHFNYFPPKSLLKLLHSCSLNECHPVNFLAKIFKPLFLQRLQGKESHLDTLSRAQLTQLFLASVLECPFYKGPKLLPKYQVKSFLTPCCSLETPVDSQLYRYVKIGLTNLLGARLYFAPKVLTPYCYTIDVEIKLDEEGFVLPSTANEDIHKRIALCIDGPKRFCSNSKHLLGKEAIKQRHLQLLGYQVVQIPYHEIGMLKSRRELVEYLQRKLFSQNTVHWLQE", "length": 662 }, "evidence": [ { "id": "Q58CX2", "url": "https://omabrowser.org/oma/group/Q58CX2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q68FN9-1", "protein_name": "FAST kinase domain-containing protein 3, mitochondrial", "gene_name": "Fastkd3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAFTLRRAFCHMSVFWMPGAVVALKIHPANNVQKAVRDCLRVWFCSLQPDLFRVRFYHAYCKSFHSENGNDLHPVGEPWFSQAQVWNQPEQTLKNEDEEMLSRRLNSFASFEEVLSFIHTLDTLPVTLASAALLRICEIGKRDDEQRLPKEVLENRVFQALCLRCERDPSHLTNAVLVTVLQSLVIDPQSSLVLSLVAECQRRLRRGSLEVHHLCVLGESLARLQGASCEILKLVICQLQSENLETFAPEDIVSVYRILQACPEEVDKHQTFLNTVNNFSLSIVSYLSPKSISHVLTALVALDQTHARPLLIKLGKSVVRYIPRFTNEELRQVLEAFVYFGHSDRFFTEALEQHVAAQCFSLDPAVASSVMEYCSRKRILSKPIFDVVAEIFVCQSEKFSPSQISELIEPFGKLNYLPPNAPALFRKVENVLFAHLRHFPPKMLLRLLHSCSLIERHPVNFMSKIFSPFFLQRLQGKESYLDRLSLAQMTQLFLTSVLECPFYKGPKLLPKYQVKSFLTPCCSLETPMDLHLYKSVVIGLIDLLGSRLYFASKVLTPYYYTIDVEIKLDEDGFVLPFTVDEDVHTRVALCIDGPQRFCLGSKHLLGKEAIKQRHLRLLGYQVVQVPYHELELLTSRLELVDYLQRKLFSQSSTVHW", "length": 656 }, "evidence": [ { "id": "Q58CX2", "url": "https://omabrowser.org/oma/group/Q58CX2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BSN9-1", "protein_name": "FAST kinase domain-containing protein 3, mitochondrial", "gene_name": "Fastkd3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFITLRRAFCHKSILWIPGAVVALKIHPASHAPKAVTDRLSVCFCSLQPELFRVRFHHAYCKNFHSEKGNDFHPVGEPWSSQAQEWNQPGQSLQNEDEEMLFRRLSYFTSFEEVLSFISALDTLPVPLAMAALLRICEIGRRDGEQRLPEGVLENRAFQALCLRCERDPSHLTNAGLVTALQSLLTLLPADPQSSLMLSLVAECQRRLQRGNLEVHHLCVLGESLAMLQGASCETLKLVVRQLQSKSVETFAPEEITSVYRILQVCPEEVDKHQMFLNTLNNFSISVVPYLSPKSISHVLTALVALDQTHALPLLIKLGKYVVRYIPRFTNEELRKVLEAFVYFGHSDRFFTEALEQHVSALCFSLDPAVASSVMGYCSRKRILSKPIFDVVSEIVVCQWDRLSPSQIAELIEPFGKLNYVPPNAPALFRKVENVLCARLHHFPPKMLLRLLHSCALIERHPVNFMSKLFSPFFLQRLQGKESYLDRLSLAQLTQLFLTSVLECPFYKGPKLLPKYQVKSFLTPCCSLETPLDLHLYKSVVIGLIDLLGSRLYFASKVLTPYYYTIDVEVKLDEDGFVLPCTVDEDIHKRVALCIDGPQRFCLDSKHLLGKEATKQRHLRLLGYQVVQLPYHELELLTSRLELVDYLQRKLFSQSSAVHW", "length": 661 }, "evidence": [ { "id": "Q58CX2", "url": "https://omabrowser.org/oma/group/Q58CX2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "mitochondrial RNA processing", "id": "GO:0000963", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000963", "evidence": [ { "database": "UniProtKB", "id": "Q58CX2", "url": "https://www.uniprot.org/uniprotkb/Q58CX2" } ], "pmid": "" }, { "name": "mitochondrial respiratory chain complex IV assembly", "id": "GO:0033617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033617", "evidence": [ { "database": "UniProtKB", "id": "Q58CX2", "url": "https://www.uniprot.org/uniprotkb/Q58CX2" } ], "pmid": "" }, { "name": "positive regulation of mitochondrial translation", "id": "GO:0070131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070131", "evidence": [ { "database": "UniProtKB", "id": "Q58CX2", "url": "https://www.uniprot.org/uniprotkb/Q58CX2" } ], "pmid": "" }, { "name": "regulation of mitochondrial mRNA stability", "id": "GO:0044528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044528", "evidence": [ { "database": "UniProtKB", "id": "Q58CX2", "url": "https://www.uniprot.org/uniprotkb/Q58CX2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q58CX2", "url": "https://www.uniprot.org/uniprotkb/Q58CX2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q58CX2", "url": "https://www.uniprot.org/uniprotkb/Q58CX2" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q58CX2", "url": "https://www.uniprot.org/uniprotkb/Q58CX2" } ], "pmid": "" }, { "name": "ribonucleoprotein granule", "id": "GO:0035770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035770", "evidence": [ { "database": "UniProtKB", "id": "Q58CX2", "url": "https://www.uniprot.org/uniprotkb/Q58CX2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 290, "end_pos": 292, "annotation": "n_glycosylation_sequon" }, { "start_pos": 424, "end_pos": 426, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CX2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 660, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CX2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CX2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58CX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CX2" }, { "id": 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"count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58CZ2-1", "uniprot_ac": "Q58CZ2", "uniprot_id": "PCMD2_BOVIN", "mass": { "chemical_mass": 40786.0, "monoisotopic_mass": 40786.0 }, "refseq": { "ac": "NP_001019650", "name": "protein-L-isoaspartate O-methyltransferase domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019650" }, "gene_names": [ { "name": "PCMTD2", "type": "recommended", "evidence": [ { "id": "Q58CZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CZ2" } ] }, { "name": "C20orf36", "type": "synonym", "evidence": [ { "id": "NP_001019650", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019650" } ] }, { "name": "PCMTD1", "type": "synonym", "evidence": [ { "id": "NP_001019650", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019650" } ] }, { "name": "PCMTD2", "type": "synonym", "evidence": [ { "id": "NP_001019650", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019650" } ] } ], "protein_names": [ { "name": "Protein-L-isoaspartate O-methyltransferase domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "Q58CZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58CZ2/entry#names_and_taxonomy" } ] }, { "name": "protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1", "type": "synonym", "evidence": [ { "id": "NP_001019650", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019650" } ] }, { "name": "protein-L-isoaspartate O-methyltransferase domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001019650", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019650" } ] } ], "function": [ { "annotation": "May act as a substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May bind to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but probably does not display methyltransferase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ2", "url": "https://www.uniprot.org/uniprotkb/Q58CZ2#function" }, { "database": "UniProtKB", "id": "Q96MG8", "url": "https://www.uniprot.org/uniprotkb/Q96MG8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58CZ2", "url": "https://www.uniprot.org/uniprotkb/Q58CZ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCMTD2", "url": "https://www.uniprot.org/uniprotkb/Q58CZ2", "locus": { "chromosome": "13", "start_pos": 53650816, "end_pos": 53669782, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031715", "url": "https://www.ensembl.org/id/ENSBTAG00000031715" } ] } } ], "crossref": [ { "id": "Q58CZ2", "url": "https://alphafold.ebi.ac.uk/entry/Q58CZ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "505807", "url": "https://www.ncbi.nlm.nih.gov/gene/505807", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000682", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000682", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505807", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505807", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58CZ2", "url": "https://www.orthodb.org/?gene=Q58CZ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11579", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11579", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11579:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11579:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01135", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01135", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001019650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019650", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58CZ2", "url": "https://www.uniprot.org/uniprotkb/Q58CZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58CZ2-1", "url": "https://www.uniprot.org/uniprotkb/Q58CZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGAVSAGEDNDELIDNLKEAQYIRSELVEQAFRAIDRADYYLEEFKENAYKDLAWKHGNIHLSAPCIYSEVMEALDLQPGLSFLNLGSGTGYLSSMVGLILGPFGVNHGVELHSDVTEYAKQKLDFFIRTSDSFDKFDFCEPSFVTGNCLEISPDCSQYDRVYCGAGVQKEHEEYMKSLLKVGGILVMPLEEKLTKITRTGPSAWETKKILAVSFAPLIQPCQSESGKSRLVQLPPLAVRSLQDLARIAIRGTIKKVIHQEAVNKNGNGLKNTPRFKRRRVRRRRLETIVFLDKEVFASRISNPSDDNSSGDLEEERREEEATTPPDAKPEPPVNFLREKVLSLPLPDPLKYYLLYYREK", "length": 361, "header": "sp|Q58CZ2-1|PCMD2_BOVIN Isoform 1 of Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 OS=Bos taurus OX=9913 GN=PCMTD2 PE=2 SV=1 CANONICAL=Q58CZ2-1" }, "isoforms": [ { "isoform_ac": "Q58CZ2-1", "url": "https://www.uniprot.org/uniprotkb/Q58CZ2/entry#Q58CZ2-1", "sequence": { "sequence": "MGGAVSAGEDNDELIDNLKEAQYIRSELVEQAFRAIDRADYYLEEFKENAYKDLAWKHGNIHLSAPCIYSEVMEALDLQPGLSFLNLGSGTGYLSSMVGLILGPFGVNHGVELHSDVTEYAKQKLDFFIRTSDSFDKFDFCEPSFVTGNCLEISPDCSQYDRVYCGAGVQKEHEEYMKSLLKVGGILVMPLEEKLTKITRTGPSAWETKKILAVSFAPLIQPCQSESGKSRLVQLPPLAVRSLQDLARIAIRGTIKKVIHQEAVNKNGNGLKNTPRFKRRRVRRRRLETIVFLDKEVFASRISNPSDDNSSGDLEEERREEEATTPPDAKPEPPVNFLREKVLSLPLPDPLKYYLLYYREK", "length": 361, "header": "sp|Q58CZ2-1|PCMD2_BOVIN Isoform 1 of Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 OS=Bos taurus OX=9913 GN=PCMTD2 PE=2 SV=1 CANONICAL=Q58CZ2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ2", "url": "https://www.uniprot.org/uniprotkb/Q58CZ2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:505807", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505807", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ2", "url": "https://www.uniprot.org/uniprotkb/Q58CZ2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-L-isoaspartate (D-aspartate) O-methyltransferase activity", "id": "GO:0004719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004719", "evidence": [ { "database": "UniProtKB", "id": "Q58CZ2", "url": "https://www.uniprot.org/uniprotkb/Q58CZ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 309, "end_pos": 311, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58CZ2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 361, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58CZ2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58CZ2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 309, "end_pos": 311 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58D05-1", "uniprot_ac": "Q58D05", "uniprot_id": "TRAD1_BOVIN", "mass": { "chemical_mass": 64847.0, "monoisotopic_mass": 64847.0 }, "refseq": { "ac": "NP_001014908", "name": "TRAF-type zinc finger domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014908" }, "gene_names": [ { "name": "TRAFD1", "type": "recommended", "evidence": [ { "id": "Q58D05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D05" } ] }, { "name": "FLN29", "type": "synonym", "evidence": [ { "id": "NP_001014908", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014908" } ] }, { "name": "TRAFD1", "type": "synonym", "evidence": [ { "id": "NP_001014908", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014908" } ] } ], "protein_names": [ { "name": "TRAF-type zinc finger domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q58D05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D05/entry#names_and_taxonomy" } ] }, { "name": "TRAF-type zinc finger domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001014908", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014908" } ] } ], "function": [ { "annotation": "Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q58D05", "url": "https://www.uniprot.org/uniprotkb/Q58D05#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58D05", "url": "https://www.uniprot.org/uniprotkb/Q58D05" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRAFD1", "url": "https://www.uniprot.org/uniprotkb/Q58D05", "locus": { "chromosome": "17", "start_pos": 62027374, "end_pos": 62046790, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008761", "url": "https://www.ensembl.org/id/ENSBTAG00000008761" } ] } } ], "crossref": [ { "id": "Q58D05", "url": "https://alphafold.ebi.ac.uk/entry/Q58D05", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008761", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008761", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512642", "url": "https://www.ncbi.nlm.nih.gov/gene/512642", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051986", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051986", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512642", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512642", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AHQSSEC", "url": "https://omabrowser.org/oma/group/AHQSSEC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58D05", "url": "https://www.orthodb.org/?gene=Q58D05", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16295", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16295", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16295:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16295:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21366", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21366", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014908", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58D05", "url": "https://www.uniprot.org/uniprotkb/Q58D05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D05-1", "url": "https://www.uniprot.org/uniprotkb/Q58D05-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D05-2", "url": "https://www.uniprot.org/uniprotkb/Q58D05-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEFLNDQDTRLCDNCKKEIPVFNFTIHEIHCQRNIGVCPVCKEPFPKCDMETHMATEHCQVTCKCNKKLEKRQLKKHEETECPLRLALCQHCDLELSVLKLKDHEDYCGARTELCGTCGRNVLVKDLKTHPEVCGRDVEEKRVEAAMPPNAYDESWGPDRIWIASQLRQIEALDPPMRLPRRPLRAFESDLFQSRTTNQRSMTAQFPIQNNLLEEQERQERNRSRQTPKERGEDSANLDFMLALSLQNEGQAPTLAEQDFWRVIYEADQSREGPSALNDIRGAVDETMLPCEFCEELYPEELLIDHQTSCNPSCALPPLSVGSTSPRGVEDPDAIFQKLMRESAGGQFESLMGFSSSAPVEDSVVIPCEFCGVQLEEEVLFHHQDQCDQRPATANNHVSEGIPSQDLQPRETSPELPKRRVRHQGDLSSGYMNDLKQEMAKGPTYPLPSSRPPNNTTAPPNRLSTSTSGPRPGCQPSPPRALKLNNLDSQGVRGHSRNSHNGALAPGHVPAAYPARSLYPENLVPSFPRGPSGRYGASSRSEGGRNPRVTPTAASYRSRTAKAKTPKQQGAGDAEEEEE", "length": 580, "header": "sp|Q58D05-1|TRAD1_BOVIN Isoform 1 of TRAF-type zinc finger domain-containing protein 1 OS=Bos taurus OX=9913 GN=TRAFD1 PE=2 SV=1 CANONICAL=Q58D05-1" }, "isoforms": [ { "isoform_ac": "Q58D05-1", "url": "https://www.uniprot.org/uniprotkb/Q58D05/entry#Q58D05-1", "sequence": { "sequence": "MAEFLNDQDTRLCDNCKKEIPVFNFTIHEIHCQRNIGVCPVCKEPFPKCDMETHMATEHCQVTCKCNKKLEKRQLKKHEETECPLRLALCQHCDLELSVLKLKDHEDYCGARTELCGTCGRNVLVKDLKTHPEVCGRDVEEKRVEAAMPPNAYDESWGPDRIWIASQLRQIEALDPPMRLPRRPLRAFESDLFQSRTTNQRSMTAQFPIQNNLLEEQERQERNRSRQTPKERGEDSANLDFMLALSLQNEGQAPTLAEQDFWRVIYEADQSREGPSALNDIRGAVDETMLPCEFCEELYPEELLIDHQTSCNPSCALPPLSVGSTSPRGVEDPDAIFQKLMRESAGGQFESLMGFSSSAPVEDSVVIPCEFCGVQLEEEVLFHHQDQCDQRPATANNHVSEGIPSQDLQPRETSPELPKRRVRHQGDLSSGYMNDLKQEMAKGPTYPLPSSRPPNNTTAPPNRLSTSTSGPRPGCQPSPPRALKLNNLDSQGVRGHSRNSHNGALAPGHVPAAYPARSLYPENLVPSFPRGPSGRYGASSRSEGGRNPRVTPTAASYRSRTAKAKTPKQQGAGDAEEEEE", "length": 580, "header": "sp|Q58D05-1|TRAD1_BOVIN Isoform 1 of TRAF-type zinc finger domain-containing protein 1 OS=Bos taurus OX=9913 GN=TRAFD1 PE=2 SV=1 CANONICAL=Q58D05-1" }, "locus": {} }, { "isoform_ac": "Q58D05-2", "url": "https://www.uniprot.org/uniprotkb/Q58D05/entry#Q58D05-2", "sequence": { "sequence": "MAEFLNDQDTRLCDNCKKEIPVFNFTIHEIHCQRNIGVCPVCKEPFPKCDMETHMATEHCQVTCKCNKKLEKRQLKKHEETECPLRLALCQHCDLELSVLKLKDHEDYCGARTELCGTCGRNVLVKDLKTHPEVCGRDVEEKRVEAAMPPNAYDESWGPDRIWIASQLRQIEALDPPMRLPRRPLRAFESDLFQSRTTNQRSMTAQFPIQNNLLEEQERQERNRSRQTPKERGEDSANLDFMLALSLQNEGQAPTLAEQDFWRVIYEADQSREGPSALNDIRGAVDETMLPCEFCEELYPEELLIDHQTSCNPSCALPPLSVGSTSPRGVEDPDAIFQKLMRESAGGQFESLMGFSSSAPVEDSVVIPCEFCGVQLEEEVLFHHQDQCDQRPATANNHVSEGIPSQDLQPRETSPELPKRRVRHQGDLSSGYMNDLKQEMAKGPTYPLPSSRPPNNTTAPPNRLSTSTSGPRPGCQPSPPRALKLNNLDSQGVRGHSRNSHNGALAPGHVPAAYPARSLYPENLVPSFPRGPSGRYGASSRSEGGRNPRVTPTAASYRSRTAKQAKTPKQQGAGDAEEEEE", "length": 581, "header": "sp|Q58D05-2|TRAD1_BOVIN Isoform 2 of TRAF-type zinc finger domain-containing protein 1 OS=Bos taurus OX=9913 GN=TRAFD1 PE=2 SV=1 CANONICAL=Q58D05-1" }, "locus": { "chromosome": "17", "start_pos": 62043613, "end_pos": 62028195, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011542.6", "url": "https://www.ensembl.org/id/ENSBTAT00000011542.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011542.6", "url": "https://www.ensembl.org/id/ENSBTAP00000011542.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 551, "start_aa": "Thr", "end_pos": 551, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr551", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 553, "start_aa": "Thr", "end_pos": 553, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr553", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 190, "end_pos": 190, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58D05", "url": "https://www.uniprot.org/uniprotkb/Q58D05" } ], "site_lbl": "Ser190" }, { "start_pos": 326, "end_pos": 326, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58D05", "url": "https://www.uniprot.org/uniprotkb/Q58D05" } ], "site_lbl": "Ser326" }, { "start_pos": 414, "end_pos": 414, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58D05", "url": "https://www.uniprot.org/uniprotkb/Q58D05" } ], "site_lbl": "Ser414" }, { "start_pos": 429, "end_pos": 429, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58D05", "url": "https://www.uniprot.org/uniprotkb/Q58D05" } ], "site_lbl": "Ser429" }, { "start_pos": 469, "end_pos": 469, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58D05", "url": "https://www.uniprot.org/uniprotkb/Q58D05" } ], "site_lbl": "Ser469" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58D05", "url": "https://www.uniprot.org/uniprotkb/Q58D05" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:512642", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512642", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5NZ72-1", "protein_name": "TRAF-type zinc finger domain-containing protein 1", "gene_name": "TRAFD1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAVTEVQTQLCGNCKKDIPAANFTIHEIHCSRNLEVCRYCKESVPKSEMKNHIESEHVQVTCKCSMKVEKSLLEDHETSACPLRPAVCQHCDIQLTFNKLQDHESYCGARTEMCSGCGLNIMVKDLKEHPQVCGKEAKRVSKTVPHFEGEDAGLHALRDIRNQLRSDNCAGPLWRMPRVLERQTYSSCVGDRTLKDISRRNVSRTQRNQNQEYGLEQPERNKNINSLYEEQNANLDHMLALSLQNENNPRNNTAAEIHRDVWENRYAKESVPSSCPNETDNSNTLPYDSLLSLNTSNHMKRDEIMLPCEFCEELYPAEDLILHQTGCNPASAFASFSKRGSLDPQKYDDLHNIGYNSCRSDYSSRYQAVQEEGNIIIPCEFCGIQLEEEIVFHHQDQCDLRPATANPADNLPSQQPPSPRDNRERRESPDLARRRIRHQGDVSPGCIEDLRQQRLNCPARGNRALSNAATARNAPLTSSGTVKTSDALNSRGKPRKVAGNEGRLKNRGAGEPASGATPCVRPTQNLHSETFTSSLSRTPVQTSIRSGRGRNPGTSDVPVGFRSRKVKAKPQSPESGYPEEE", "length": 582 }, "evidence": [ { "id": "Q58D05", "url": "https://omabrowser.org/oma/group/Q58D05/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RJM4-1", "protein_name": "TRAF-type zinc finger domain-containing protein 1", "gene_name": "TRAFD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAEFLDDQDTRLCDNCKKEIPVFNFTIHEIHCQRNIGMCAICKEPFPKSDMETHMATEHCQVTCKCNKKLEKRQLKKHEETECPLRLALCQHCDLELSVLKLKDHEDYCGARTELCGSCGRNVLVKDLKTHPEVCGRNEEEKRDEVTMLPNAYDDSWGQDGIWIASQLRQIEALDPPMRLPRRPLRAFESDLFQSRTTSQRSVTAQFPIQNNLLEEQESQERNRRRQTPKEGGEDSANLDFMLALSLQNEGQPPNMAEQDLWRVVCEADQSHEGPSALNDIRGAADGTMLPCEFCEELYPEELLIDHQTSCNPSCALPPLGVGSTSPKGMEDPDVIFQEIMQQAARNQLDSLGLRSSPPVEDSIIIPCEFCGVQLEEEVLFHHQDQCDQRPATANNHVSEGIPRQDFQPRGTSPELPKRRVRHQGDLSSDYMDDIKQEMAKGPTYPLPLSRPINNMTATSNRLSVSTSGPRPGCQPSPPRTLKLNNLDNQGIRGRNRNSHNGALASEQIPAVHPARSLYPENLVSAFPRGPSGRYGASGRSEGGRNSRVTPTTTSYCSRTVKAKPPKQQGAGDAEEEEEEE", "length": 581 }, "evidence": [ { "id": "Q58D05", "url": "https://omabrowser.org/oma/group/Q58D05/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H282-1", "protein_name": "TRAF-type zinc finger domain-containing protein 1", "gene_name": "Trafd1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAEFADDQAARLCDNCKKEIPVFNFTIHEIHCQRNIGVCPVCKEPFPKSDMDVHMATEHCQVTCKCNKKLEKRQLKQHMETECPLRLAVCQHCDLELSVLKLKEHEDYCGARTELCGSCGRNVLVKELKTHPEVCGRVEEEKKNEAALPPDAYDEPWNQDGIWIASQLLRQIEALDPPMRLPGRPLRAFESDPFHSRPISQRNTTAHFPIQNNLFEEQERQERNRSRQSPKESGENNAHLDFMLALSLQNEGQASSMAEQGFWGSVPEADPAHGGPTSLSDIKGAADETLLPCEFCEELYPEELLIDHQTSCNPSHALRSLNTGSSSIRGVEDPGVIFQNFLQQATSNQLDTLVGMSNTAAVEESIIIPCEFCGVQLEEEVLFHHQDQCDQRPATGNHHAMEGIPTQDSQPEDTSPELPKRLVKHQGDPSSGYMDVKQEAAKGSTCSLSPSRTMNNVTTCNPRSECQPSPPRVLKLNNSDSQDRGQSRGSQNGPVASGHAPVIHSIRNIYPENLVPSFPHGPSGRYGASGRSEGGQSSRVTPTAASYHSRAPKAKPPKQQGAGDAEEEEE", "length": 570 }, "evidence": [ { "id": "Q58D05", "url": "https://omabrowser.org/oma/group/Q58D05/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O14545-1", "protein_name": "TRAF-type zinc finger domain-containing protein 1", "gene_name": "TRAFD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHCQVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMRLPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEESANLDFMLALSLQNEGQASSVAEQDFWRAVCEADQSHGGPRSLSDIKGAADEIMLPCEFCEELYPEELLIDHQTSCNPSRALPSLNTGSSSPRGVEEPDVIFQNFLQQAASNQLDSLMGLSNSHPVEESIIIPCEFCGVQLEEEVLFHHQDQCDQRPATATNHVTEGIPRLDSQPQETSPELPRRRVRHQGDLSSGYLDDTKQETANGPTSCLPPSRPINNMTATYNQLSRSTSGPRPGCQPSSPCVPKLSNSDSQDIQGRNRDSQNGAIAPGHVSVIRPPQNLYPENIVPSFSPGPSGRYGASGRSEGGRNSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE", "length": 582 }, "evidence": [ { "id": "Q58D05", "url": "https://omabrowser.org/oma/group/Q58D05/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q3UDK1-1", "protein_name": "TRAF-type zinc finger domain-containing protein 1", "gene_name": "Trafd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEFRDDQASRLCDNCKKEIPVFNFTIHEIHCQRNIGVCPVCKEPFPKSDMDIHMAAEHCQVTCKCNKKLEKRQLKQHAETECPLRLAVCQHCDLELSVVKLKEHEDYCGARTELCGSCGRNVLVKELKTHPEVCGRVEEEKRTEAAIPPEAYDEPWSQDRIWIASQLLRQIEALDPPMRLPGRPLQAFEADPFYSRTTSQRSMAAQFPVQNNLFEEQERQERNRSRQSPKDSAENNAHLDFMLALSLQNEGQATSMVEQGFWESVPEADPARAGPTSLGDIKGAADEILLPCEFCEELYPEELLIDHQTSCNPSHALRSLNTGSSSIRGVEDPGTIFQNFLQQATSNQFDTLMGLSSSAAVEDSIIIPCEFCGVQLEEEVLFYHQDQCDQRPATANHRAVEGIPAQDSQPENTSAELSRRRVKHQGDLSSGYMDDVKPESVKGPTYSMSPNRTMNNVASCNRLLNLPSGPRSDCQRSPPGVLKLNNSDSQDIRGQMRGSQNGPIASGHAPVIHSIQNLYPENFAPSFPHGSPGRYGAGGRSEGGRSSRVSPAAAGYHSRAAKAKPPKQQGAGDAEEEEE", "length": 580 }, "evidence": [ { "id": "Q58D05", "url": "https://omabrowser.org/oma/group/Q58D05/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q99MM4-1", "protein_name": "TRAF-type zinc finger domain-containing protein 1", "gene_name": "Trafd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEFPDDQAARLCDNCKKEIPVFNFTIHEIHCQRNIGVCPVCKEPFPKSDMDIHVATEHCQVTCKCNKKLEKRQLKQHVETECPLRLAVCQHCDLELSVVKLKEHEDYCGARTELCGSCGRNVLVKELQTHPAVCGRVEEEKRSEAAVPPEAYDEPWSQDRIWIASQLLRQIEALDPPMRLPGRPLRAFEADPFYSRTASQRGVTAHFPIQNNLFEEQERQERNRSHQSPKDSAENSAHLDFMLALSLQNEGQASSMVEQGFWESVPEADPARAGPTSLGDIKGAADETLLPCEFCEELYPEELLIDHQTSCNPSHALRSLNTGSSSIRGVEDPGAIFQNFLQQATSNQLDTLMGLSSSAAVEDSIIIPCEFCGVQLEEEVLFHHQDQCDQRPATANHRAMEGIPTQDSQPEDRSPELSRRRVKHQGDLSSGYMDDVKQESVKGSTYSLSPNRTMNNVSTCNRLLNSSGPRSDCQRSPPGVLKLNNSGSQDIRGRIRGSQNGPIASAHAPVIHSIRNLYPENLAPSFPHGSPGRFGASEGSRSSRVTPTAASYHSRAAKAKPPKQQGAGDAEEEEE", "length": 576 }, "evidence": [ { "id": "Q58D05", "url": "https://omabrowser.org/oma/group/Q58D05/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q58D05", "url": "https://www.uniprot.org/uniprotkb/Q58D05" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q58D05", "url": "https://www.uniprot.org/uniprotkb/Q58D05" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of innate immune response", "id": "GO:0045824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045824", "evidence": [ { "database": "UniProtKB", "id": "Q58D05", "url": "https://www.uniprot.org/uniprotkb/Q58D05" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 223, "end_pos": 225, "annotation": "n_glycosylation_sequon" }, { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" }, { "start_pos": 455, "end_pos": 457, "annotation": "n_glycosylation_sequon" }, { "start_pos": 456, "end_pos": 458, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58D05-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 580, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58D05-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58D05" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 551, 553 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 190, 326, 414, 429, 469 ], "sequon_annotation_sites": [ { "start_pos": 223, "end_pos": 225 }, { "start_pos": 24, "end_pos": 26 }, { "start_pos": 455, "end_pos": 457 }, { "start_pos": 456, "end_pos": 458 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58D08-1", "uniprot_ac": "Q58D08", "uniprot_id": "P5CR3_BOVIN", "mass": { "chemical_mass": 32035.0, "monoisotopic_mass": 32035.0 }, "refseq": { "ac": "NP_001014906", "name": "pyrroline-5-carboxylate reductase 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014906" }, "gene_names": [ { "name": "PYCR3", "type": "recommended", "evidence": [ { "id": "Q58D08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D08" } ] }, { "name": "PYCR3", "type": "synonym", "evidence": [ { "id": "NP_001014906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014906" } ] }, { "name": "PYCRL", "type": "synonym", "evidence": [ { "id": "NP_001014906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014906" }, { "id": "Q58D08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D08" } ] } ], "protein_names": [ { "name": "Pyrroline-5-carboxylate reductase 3", "type": "recommended", "evidence": [ { "id": "Q58D08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D08/entry#names_and_taxonomy" } ] }, { "name": "1.5.1.2", "type": "synonym", "evidence": [ { "id": "Q58D08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D08/entry#names_and_taxonomy" } ] }, { "name": "P5C reductase 3", "type": "synonym", "evidence": [ { "id": "NP_001014906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014906" }, { "id": "Q58D08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D08/entry#names_and_taxonomy" } ] }, { "name": "P5CR 3", "type": "synonym", "evidence": [ { "id": "NP_001014906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014906" }, { "id": "Q58D08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D08/entry#names_and_taxonomy" } ] }, { "name": "Pyrroline-5-carboxylate reductase-like protein", "type": "synonym", "evidence": [ { "id": "Q58D08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D08/entry#names_and_taxonomy" } ] }, { "name": "pyrroline-5-carboxylate reductase 3", "type": "synonym", "evidence": [ { "id": "NP_001014906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014906" } ] }, { "name": "pyrroline-5-carboxylate reductase-like protein", "type": "synonym", "evidence": [ { "id": "NP_001014906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014906" } ] } ], "function": [ { "annotation": "Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate (P5C) to L-proline using NAD(P)H. Proline is synthesized from either glutamate or ornithine; both are converted to P5C, and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCR3 is exclusively linked to the biosynthesis of proline from ornithine.", "evidence": [ { "database": "UniProtKB", "id": "Q58D08", "url": "https://www.uniprot.org/uniprotkb/Q58D08#function" }, { "database": "UniProtKB", "id": "Q53H96", "url": "https://www.uniprot.org/uniprotkb/Q53H96#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58D08", "url": "https://www.uniprot.org/uniprotkb/Q58D08" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PYCR3", "url": "https://www.uniprot.org/uniprotkb/Q58D08", "locus": { "chromosome": "14", "start_pos": 1108734, "end_pos": 1101602, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016810", "url": "https://www.ensembl.org/id/ENSBTAG00000016810" } ] } } ], "crossref": [ { "id": "Q58D08", "url": "https://alphafold.ebi.ac.uk/entry/Q58D08", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016810", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016810", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512526", "url": "https://www.ncbi.nlm.nih.gov/gene/512526", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008927", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008927", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028939", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512526", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512526", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AKQTCLG", "url": "https://omabrowser.org/oma/group/AKQTCLG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58D08", "url": "https://www.orthodb.org/?gene=Q58D08", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11645", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11645", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11645:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11645:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03807", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03807", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14748", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14748", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8964539", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8964539", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001014906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014906", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "14105", "url": "https://www.rhea-db.org/rhea/14105", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "14109", "url": "https://www.rhea-db.org/rhea/14109", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58D08", "url": "https://www.uniprot.org/uniprotkb/Q58D08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D08-1", "url": "https://www.uniprot.org/uniprotkb/Q58D08-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAAEESGWRRVGFVGAGRMAEAIAQGLIQAGKVEAEHVLASAPSDRNLCRFRAMGCQTTHSNLEVLHSCSLVFFATKPHILPAVLVEVAPAVTAEHILVSVAAGVSLSTLEKLLPPMARVLRVSPNLPCIVQEGAMVMARGCCAGSYEAQLLRSLLEACGQCEEVPEAQVDVHTGLSGSGVAFVCAFSEALAEGAIKMGMPSGLAHRIAAQTLLGTAKVLLQKGQHPAQLRTDVCTPGGTTIYGLHVLEQGGLRATAMSAVEAATCRARELSRNPSPVVAQVPSVLQALQGEGALAHREHSSVARS", "length": 308, "header": "sp|Q58D08-1|P5CR3_BOVIN Isoform 1 of Pyrroline-5-carboxylate reductase 3 OS=Bos taurus OX=9913 GN=PYCR3 PE=2 SV=1 CANONICAL=Q58D08-1" }, "isoforms": [ { "isoform_ac": "Q58D08-1", "url": "https://www.uniprot.org/uniprotkb/Q58D08/entry#Q58D08-1", "sequence": { "sequence": "MAAAAEESGWRRVGFVGAGRMAEAIAQGLIQAGKVEAEHVLASAPSDRNLCRFRAMGCQTTHSNLEVLHSCSLVFFATKPHILPAVLVEVAPAVTAEHILVSVAAGVSLSTLEKLLPPMARVLRVSPNLPCIVQEGAMVMARGCCAGSYEAQLLRSLLEACGQCEEVPEAQVDVHTGLSGSGVAFVCAFSEALAEGAIKMGMPSGLAHRIAAQTLLGTAKVLLQKGQHPAQLRTDVCTPGGTTIYGLHVLEQGGLRATAMSAVEAATCRARELSRNPSPVVAQVPSVLQALQGEGALAHREHSSVARS", "length": 308, "header": "sp|Q58D08-1|P5CR3_BOVIN Isoform 1 of Pyrroline-5-carboxylate reductase 3 OS=Bos taurus OX=9913 GN=PYCR3 PE=2 SV=1 CANONICAL=Q58D08-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58D08", "url": "https://www.uniprot.org/uniprotkb/Q58D08" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:512526", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512526", "resource": "KEGG Pathway" }, { "id": "R-BTA-8964539", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8964539", "resource": "Reactome", "description": "Glutamate and glutamine metabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A3W3-1", "protein_name": "Pyrroline-5-carboxylate reductase", "gene_name": "PYCR3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAAAETGPRRVGFVGAGRMAEAIAQGLIRAGKVEAQYVLASAPTDRNLCHFRALGCRTTHSNHEVLQSCSLVIFATKPHVLPAVLAEVAPVVTTEHILVSVAAGVPLSTMEELLPPGARVLRVSPNLPCVVQEGAMVLARGRHAGNSEAELLQTLLEACGQCEEVPEAQVDTHTGLSGSGVAFVCAFSEALAEGAIKMGMPSGLAYRIAAQTLLGTAKMLLQKGQHPAQLRTDVCTPGGTTIYGLHALEQGGLRAAAMSAVEAATRRAKEMRKWRG", "length": 277 }, "evidence": [ { "id": "Q58D08", "url": "https://omabrowser.org/oma/group/Q58D08/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q53H96-1", "protein_name": "Pyrroline-5-carboxylate reductase 3", "gene_name": "PYCR3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAEPSPRRVGFVGAGRMAGAIAQGLIRAGKVEAQHILASAPTDRNLCHFQALGCRTTHSNQEVLQSCLLVIFATKPHVLPAVLAEVAPVVTTEHILVSVAAGVSLSTLEELLPPNTRVLRVLPNLPCVVQEGAIVMARGRHVGSSETKLLQHLLEACGRCEEVPEAYVDIHTGLSGSGVAFVCAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYGLHALEQGGLRAATMSAVEAATCRAKELSRK", "length": 274 }, "evidence": [ { "id": "Q58D08", "url": "https://omabrowser.org/oma/group/Q58D08/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5SPD7-1", "protein_name": "Pyrroline-5-carboxylate reductase 3", "gene_name": "pycr3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSLSGASDKTSDSPDVFQIKIGFIGAGNMAFGVAQGIIASGKVPPSNIIISAPSMNNLPRFKEKGVSVTHSNHEVVGGSRLIFLAVKPHIIPQVLKEISQEVTKEHIIVSMAAGITIATLEELLPAGTHVIRIMPNLPCMLLEGALLLSCGSHAGEQEETLLKTLLGPCGLVEFGPESWIDAHVGLSGSGVAFVYVFAEALADGAVKMGMPSTLARRIAAQTILGAGVLLRDSGKLPAELKAEVCTPGGTTIHGIHALEKGGFRAAAIGAVEAASERARELGNKQKKN", "length": 288 }, "evidence": [ { "id": "Q58D08", "url": "https://omabrowser.org/oma/group/Q58D08/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9DCC4-1", "protein_name": "Pyrroline-5-carboxylate reductase 3", "gene_name": "Pycr3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAATMSEPRRVGFVGAGRMAEAIARGLIQAGKVEAKQVLASAPTDNNLCHFRALGCQTTHSNHEVLQNCPLVIFATKPQVLPTVLAEVAPIVTTEHIIVSVAAGISLSTMEGLLPPNTRVLRVSPNLPCVVQEGAMVMARGHHAGNDDAELLQNLLEACGQCIEVPESYVDIHTGLSGSGVAFVCTFSEALAEGAIKMGMPSGLAHRIAAQTLLGTAKMLQQEGKHPAQLRTDVLTPAGTTIHGLHALERGGFRAATMSAVEAATCRAKELSKK", "length": 274 }, "evidence": [ { "id": "Q58D08", "url": "https://omabrowser.org/oma/group/Q58D08/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "pyrroline-5-carboxylate reductase activity", "id": "GO:0004735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004735", "evidence": [ { "database": "UniProtKB", "id": "Q58D08", "url": "https://www.uniprot.org/uniprotkb/Q58D08" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q58D08", "url": "https://www.uniprot.org/uniprotkb/Q58D08" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "L-proline biosynthetic process", "id": "GO:0055129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055129", "evidence": [ { "database": "UniProtKB", "id": "Q58D08", "url": "https://www.uniprot.org/uniprotkb/Q58D08" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "14105", "name": "", "equation": "L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9TES5-1", "Q58DT4-1", "Q17QJ7-1", "Q58D08-1" ], "evidence": [ { "id": "14105", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14105" } ] }, { "id": "14109", "name": "", "equation": "L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9TES5-1", "Q58DT4-1", "Q17QJ7-1", "Q58D08-1" ], "evidence": [ { "id": "14109", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14109" } ] }, { "id": "R-BTA-6783955", "name": "PYCR3 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q58D08-1" ], "evidence": [ { "id": "R-BTA-6783955", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6783955" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9TES5", "gene_name": "PYCR3", "activity": [ { "ec_number": "1.5.1.2", "activity": "L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+).", "evidence": [ { "id": "A0AAA9TES5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES5" } ] }, { "ec_number": "1.5.1.2", "activity": "", "evidence": [ { "id": "A0AAA9TES5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TES5" } ] } ] }, { "uniprot_ac": "Q17QJ7", "gene_name": "PYCR2", "activity": [ { "ec_number": "1.5.1.2", "activity": "L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+).", "evidence": [ { "id": "Q17QJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ7" } ] }, { "ec_number": "1.5.1.2", "activity": "", "evidence": [ { "id": "Q17QJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ7" } ] } ] }, { "uniprot_ac": "Q58D08", "gene_name": "PYCR3", "activity": [ { "ec_number": "1.5.1.2", "activity": "L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+).", "evidence": [ { "id": "Q58D08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D08" } ] }, { "ec_number": "1.5.1.2", "activity": "", "evidence": [ { "id": "Q58D08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D08" } ] } ] }, { "uniprot_ac": "Q58DT4", "gene_name": "PYCR1", "activity": [ { "ec_number": "1.5.1.2", "activity": "L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+).", "evidence": [ { "id": "Q58DT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DT4" } ] }, { "ec_number": "1.5.1.2", "activity": "", "evidence": [ { "id": "Q58DT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DT4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58D08-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 308, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58D08-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58D08" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.5.1.2", "ec_name": "L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+).", "evidence": [ { "id": "1.5.1.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2" }, { "id": "1.5.1.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.5.1.2" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58D15-1", "uniprot_ac": "Q58D15", "uniprot_id": "TRI54_BOVIN", "mass": { "chemical_mass": 41337.0, "monoisotopic_mass": 41337.0 }, "refseq": { "ac": "NP_001017951", "name": "tripartite motif-containing protein 54", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017951" }, "gene_names": [ { "name": "TRIM54", "type": "recommended", "evidence": [ { "id": "Q58D15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D15" } ] }, { "name": "TRIM54", "type": "synonym", "evidence": [ { "id": "NP_001017951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017951" } ] } ], "protein_names": [ { "name": "Tripartite motif-containing protein 54", "type": "recommended", "evidence": [ { "id": "Q58D15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D15/entry#names_and_taxonomy" } ] }, { "name": "ring finger protein 30", "type": "synonym", "evidence": [ { "id": "NP_001017951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017951" } ] }, { "name": "tripartite motif-containing protein 54", "type": "synonym", "evidence": [ { "id": "NP_001017951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017951" } ] } ], "function": [ { "annotation": "May bind and stabilize microtubules during myotubes formation.", "evidence": [ { "database": "UniProtKB", "id": "Q58D15", "url": "https://www.uniprot.org/uniprotkb/Q58D15#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58D15", "url": "https://www.uniprot.org/uniprotkb/Q58D15" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRIM54", "url": "https://www.uniprot.org/uniprotkb/Q58D15", "locus": { "chromosome": "11", "start_pos": 72337030, "end_pos": 72358216, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018267", "url": "https://www.ensembl.org/id/ENSBTAG00000018267" } ] } } ], "crossref": [ { "id": "Q58D15", "url": "https://alphafold.ebi.ac.uk/entry/Q58D15", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018267", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018267", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16761", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16761", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19833", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19833", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535320", "url": "https://www.ncbi.nlm.nih.gov/gene/535320", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033492", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033492", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535320", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535320", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MEDICRT", "url": "https://omabrowser.org/oma/group/MEDICRT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58D15", "url": "https://www.orthodb.org/?gene=Q58D15", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00643", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00643", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13445", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13445", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001017951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017951", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58D15", "url": "https://www.uniprot.org/uniprotkb/Q58D15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D15-1", "url": "https://www.uniprot.org/uniprotkb/Q58D15-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNFTVGFKPLLGDAHSMDNLEKQLICPICLEMFSKPVVILPCQHNLCRKCANDVFQASNPLWQSRSSTTVSSGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESSRPLHSKAEQHLMCEEHEDEKINIYCLSCEVPTCSLCKVFGAHKDCEVAPLPTIYKRQKSELSDGIAMLVAGNDRVQAVITQMEEVCQTIEENSRRQKQLLNQRFEGLCAVLEERKGELLQALAREQEEKLQRVRGLIRQYGDHLEASSKLVESAIQSMEEPQMALYLQQAKELINKVGTMSKVELAGRPEPGYERMDQFTVSVEHVAEMLRTIDFQPGTSGEEEDEEVAVEGEEGNAGPEEERTDGRESTGQH", "length": 366, "header": "sp|Q58D15-1|TRI54_BOVIN Isoform 1 of Tripartite motif-containing protein 54 OS=Bos taurus OX=9913 GN=TRIM54 PE=2 SV=1 CANONICAL=Q58D15-1" }, "isoforms": [ { "isoform_ac": "Q58D15-1", "url": "https://www.uniprot.org/uniprotkb/Q58D15/entry#Q58D15-1", "sequence": { "sequence": "MNFTVGFKPLLGDAHSMDNLEKQLICPICLEMFSKPVVILPCQHNLCRKCANDVFQASNPLWQSRSSTTVSSGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESSRPLHSKAEQHLMCEEHEDEKINIYCLSCEVPTCSLCKVFGAHKDCEVAPLPTIYKRQKSELSDGIAMLVAGNDRVQAVITQMEEVCQTIEENSRRQKQLLNQRFEGLCAVLEERKGELLQALAREQEEKLQRVRGLIRQYGDHLEASSKLVESAIQSMEEPQMALYLQQAKELINKVGTMSKVELAGRPEPGYERMDQFTVSVEHVAEMLRTIDFQPGTSGEEEDEEVAVEGEEGNAGPEEERTDGRESTGQH", "length": 366, "header": "sp|Q58D15-1|TRI54_BOVIN Isoform 1 of Tripartite motif-containing protein 54 OS=Bos taurus OX=9913 GN=TRIM54 PE=2 SV=1 CANONICAL=Q58D15-1" }, "locus": { "chromosome": "11", "start_pos": 72357868, "end_pos": 72337174, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024312.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024312.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024312.4", "url": "https://www.ensembl.org/id/ENSBTAP00000024312.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58D15", "url": "https://www.uniprot.org/uniprotkb/Q58D15" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:535320", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535320", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZKH6-1", "protein_name": "Tripartite motif-containing protein 54", "gene_name": "TRIM54", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNFTVGFKPLLGDAHSMDNLEKQLICPICLEMFSKPVVILPCQHNLCRKCANDVFQASNPLWQSRGSTTVSSGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESSRPLHTKAEQHLMCEEHEDEKINIYCLSCEVPTCSLCKVFGAHKDCEVAPLPTIYKRQKSELSDGIAMLVAGNDRVQAVITQMEEVCQTIEDNSRRQKQLLNQRFEALCAVLEERKGELLQALAKVQEEKLQRVRGLIRQYGDHLEASSKLVESAIQSMEEPQMALYLQQAKELINKVGTMSKVELAGRPEPGYESMEQFRVSVEHVAEMLRTIDFQPGASGEEEDEEVALDGEEGSAGPEEERPDGPEGLH", "length": 364 }, "evidence": [ { "id": "Q58D15", "url": "https://omabrowser.org/oma/group/Q58D15/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A3L7HB16-1", "protein_name": "Tripartite motif-containing protein 54", "gene_name": "Trim54", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNFTVGFKPLLGDAHNMDNLEKQLICPICLEMFSKPVVILPCQHNLCRKCANDVFQASNPLWQSRGSTTVSSGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESSRPLHSKAEQHLMCEEHEDEKINIYCLSCEVPTCSLCKVFGAHKDCEVAPLPTIYKRQKSELSDGIAMLVAGNDRVQAVITQMEEVCQTIEDNSRRQKQLLNQRFETLCAVLEERKGELLQALAREQEEKLQRVRGLIRQYGDHLEVSSKLVESAIQSMEEPQMALYLQQAKELINKVGAMSKVELAGRPEPGYESMEQFSVNVEHVAEMLRTIDFQPGAAGDEEDDEVALEGDESNAGLEEERLDGPEGLH", "length": 364 }, "evidence": [ { "id": "Q58D15", "url": "https://omabrowser.org/oma/group/Q58D15/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5RHH1-1", "protein_name": "Tripartite motif-containing protein 54", "gene_name": "trim54", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNFTLGFKPSIGDSSSMENLERQLICPICLEIFSKPVVILPCQHNLCRKCANDVFQASNPLWQNRASTTVSTGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKSESTRPLLPKTEQQQLMCDQHEEEKINIYCLTCETPTCSMCKVFGAHKDCDVAPLPVIYKKQKTELSDAIAILVAGNDSIQALISQMEDICRSIKDNGRRQIQHISDKFDELYAILEERKRELIETVGCEQDRKLGHVRSLIRRHGDHLEMSVKLVETAIQSMEEPQMAVFLQSTKDVFKKITDTAKASNIERTEVGYESMAHFIINTEDVANMLRHINFRTGKDEEDSGDEAPEGLTTSTGQSGESGTR", "length": 359 }, "evidence": [ { "id": "Q58D15", "url": "https://omabrowser.org/oma/group/Q58D15/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5XIH6-1", "protein_name": "Tripartite motif-containing protein 54", "gene_name": "Trim54", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNFTVGFKPLLGDAHNMDNLEKQLICPICLEMFSKPVVILPCQHNLCRKCANDVFQASNPLWQSRGSTTVSSGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESSRPLHSKAEQHLMCEEHEDEKINIYCLSCEVPTCSLCKVFGAHKDCEVAPLPTIYKRQKSELSDGIAMLVAGNDRVQAVITQMEEVCQTIEDNSRRQKQLLNQKFETLCAVLEERKGELLQALARVQEEKLQRVRSLIRQYGDHLEASSKLVESAIQSMEEPQMALYLQQAKELINKVGAMSKVELAGRPEPGYESMEQFSVIVEHVAEMLRTIDFQPGASGDEEDDEVTLDGEEGNTGLEEERLDGPEGLH", "length": 364 }, "evidence": [ { "id": "Q58D15", "url": "https://omabrowser.org/oma/group/Q58D15/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9BYV2-1", "protein_name": "Tripartite motif-containing protein 54", "gene_name": "TRIM54", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNFTVGFKPLLGDAHSMDNLEKQLICPICLEMFSKPVVILPCQHNLCRKCANDVFQASNPLWQSRGSTTVSSGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESSRPLHSKAEQHLMCEEHEEEKINIYCLSCEVPTCSLCKVFGAHKDCEVAPLPTIYKRQKSELSDGIAMLVAGNDRVQAVITQMEEVCQTIEDNSRRQKQLLNQRFESLCAVLEERKGELLQALAREQEEKLQRVRGLIRQYGDHLEASSKLVESAIQSMEEPQMALYLQQAKELINKVGAMSKVELAGRPEPGYESMEQFTVRVEHVAEMLRTIDFQPGASGEEEEVAPDGEEGSAGPEEERPDGP", "length": 358 }, "evidence": [ { "id": "Q58D15", "url": "https://omabrowser.org/oma/group/Q58D15/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9ERP3-1", "protein_name": "Tripartite motif-containing protein 54", "gene_name": "Trim54", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNFTVGFKPLLGDAHNMDNLEKQLICPICLEMFSKPVVILPCQHNLCRKCANDVFQASNPLWQSRGSTTVSSGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESSRPLHAKAEQHLMCEEHEDEKINIYCLSCEVPTCSLCKVFGAHKDCEVAPLPTIYKRQKSELSDGIAMLVAGNDRVQAVITQMEEVCQTIEDNSRRQKQLLNQRFETLCAVLEERKGELLQALAREQEEKLQRVRGLIRQYGDHLEGSSKLVESAIQSMEEPQMALYLQQAKELINKVGAMSKVELAGRPEPGYESMEQFSVSVEHVAEMLRTIDFQPGAAGDEEDDDMALDGEEGNAGLEEERLDVPEGSGLH", "length": 366 }, "evidence": [ { "id": "Q58D15", "url": "https://omabrowser.org/oma/group/Q58D15/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58D15", "url": "https://www.uniprot.org/uniprotkb/Q58D15" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "Q58D15", "url": "https://www.uniprot.org/uniprotkb/Q58D15" } ], "pmid": "" }, { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "Q58D15", "url": "https://www.uniprot.org/uniprotkb/Q58D15" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q58D15", "url": "https://www.uniprot.org/uniprotkb/Q58D15" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "Q58D15", "url": "https://www.uniprot.org/uniprotkb/Q58D15" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q58D15", "url": "https://www.uniprot.org/uniprotkb/Q58D15" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "Q58D15", "url": "https://www.uniprot.org/uniprotkb/Q58D15" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58D15-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 366, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58D15-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58D15" } ], 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"Q58D56", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:507472", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507472", "resource": "KEGG Pathway" }, { "id": "R-BTA-9629569", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9629569", "resource": "Reactome", "description": "Protein hydroxylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2KAI8-1", "protein_name": "Developmentally regulated GTP binding protein 2", "gene_name": "Drg2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGILEKISEIEKEIARTQKNKATEYHLGLLKAKLAKYRAQLLEPSKSASSKGEGFDVMKSGDARVALIGFPSVGKSTFLSLMTSTASEAASYEFTTLTCIPGVIEYKGANIQLLDLPGIIEGAAQGGSRKRDLASVYAIRAALTQPLSRSLLEKELESVGIRLNKHKPNIYFKPKKGGGISFNSTVTLTQCSEKLVQLILHEYKIFNAEVLFREDCSPDDFIDVIVGNRVYMPCLYVYNKIDQISMEEVDRLARKPNSVVIRQGLCIALADLELTVWRGLALNSYISTCLPSPRTGIKDVHRLQGSVPVRKKALGKPVCHRIHRSLASQFKYALVWGTSTKYSPQRVGLTHTMEHEDVIQIVKK", "length": 364 }, "evidence": [ { "id": "Q58D56", "url": "https://omabrowser.org/oma/group/Q58D56/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NIK3-1", "protein_name": "Developmentally-regulated GTP-binding protein 2", "gene_name": "DRG2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGILEKISEIEKEIARTQKNKATEYHLGLLKAKLAKYRAQLLEPSKSSAAKGEGFDVMKSGDARVALIGFPSVGKSTFLSLMTSTASEAASYEFTTLTCIPGVIEYKGANIQLLDLPGIIEGAAQGKGRGRQVIAVARTADVVIMMLDATKGEVQRALLEKELESVGIRLNKSKPNIYFKPKKGGGISFNSTVTLTQCSEKLVQLILHEYKIFNAEVLFREDCSPDEFIDVIVGNRVYMPCLYVYNKIDQISMEEVDRLARRPHSVVISCGMKLNLDYLLEKLWEYLALTCIYTKKRGQRPDFTDAIILRKGASVEHVCHRIHRSLASQFKYALVWGTSTKYSPQRVGLTHMMEHEDVIQIVKK", "length": 364 }, "evidence": [ { "id": "Q58D56", "url": "https://omabrowser.org/oma/group/Q58D56/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3GVH4-1", "protein_name": "Developmentally-regulated GTP-binding protein 2", "gene_name": "Drg2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGILEKISEIEKEIARTQKNKATEYHLGLLKAKLAKYRAQLLEPSKSASSKGEGFDVMKSGDARVALIGFPSVGKSTFLSLMTSTASEAASYEFTTLTCIPGVIEYKGANIQLLDLPGIIEGAAQGRGRGRQVIAVARTADVVVMMLDATKGDVQRSLLEKELESVGIRLNKHKPNIYFKPKKGGGISFNSTVTLTQCSEKLVQLILHEYKIFNAEVLFREDCSPDEFIDVIVGNRVYMPCLYVYNKIDQISMEEVDRLARKPNSVVISCGMKLNLDYLLEMLWEYLALTCIYTKKRGQRPDFTDAIILRKGASVEHVCHRIHRSLASQFKYALVWGTSTKYSPQRVGLTHTMEHEDVIQIVKK", "length": 364 }, "evidence": [ { "id": "Q58D56", "url": "https://omabrowser.org/oma/group/Q58D56/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P53295-1", "protein_name": "Ribosome-interacting GTPase 2", "gene_name": "RBG2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MGIIDKIKAIEEEMARTQKNKATEHHLGLLKGKLARYRQQLLADEAGSGGGGGSGFEVAKSGDARVVLIGYPSVGKSSLLGKITTTKSEIAHYAFTTLTSVPGVLKYQGAEIQIVDLPGIIYGASQGKGRGRQVVATARTADLVLMVLDATKSEHQRASLEKELENVGIRLNKEKPNIYYKKKETGGVKVTFTSPPKTNLTEQAIKMILRDYRIHNAEVLVRDDQCTIDDFIDVINEQHRNYVKCLYVYNKIDAVSLEEVDKLAREPNTVVMSCEMDLGLQDVVEEIWYQLNLSRVYTKKRGVRPVFDDPLVVRNNSTIGDLCHGIHRDFKDKFKYALVWGSSAKHSPQKCGLNHRIDDEDVVSLFAK", "length": 368 }, "evidence": [ { "id": "Q58D56", "url": "https://omabrowser.org/oma/group/Q58D56/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P55039-1", "protein_name": "Developmentally-regulated GTP-binding protein 2", "gene_name": "DRG2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGILEKISEIEKEIARTQKNKATEYHLGLLKAKLAKYRAQLLEPSKSASSKGEGFDVMKSGDARVALIGFPSVGKSTFLSLMTSTASEAASYEFTTLTCIPGVIEYKGANIQLLDLPGIIEGAAQGKGRGRQVIAVARTADVIIMMLDATKGEVQRSLLEKELESVGIRLNKHKPNIYFKPKKGGGISFNSTVTLTQCSEKLVQLILHEYKIFNAEVLFREDCSPDEFIDVIVGNRVYMPCLYVYNKIDQISMEEVDRLARKPNSVVISCGMKLNLDYLLEMLWEYLALTCIYTKKRGQRPDFTDAIILRKGASVEHVCHRIHRSLASQFKYALVWGTSTKYSPQRVGLTHTMEHEDVIQIVKK", "length": 364 }, "evidence": [ { "id": "Q58D56", "url": "https://omabrowser.org/oma/group/Q58D56/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54WT4-1", "protein_name": "Developmentally-regulated GTP-binding protein 2 homolog", "gene_name": "drg2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGILEKIKDIEAEMSRTQKNKATEYHLGLLKAKLARLRQQLLDPPKSSGKGGDGFEVLKSGDARVALIGFPSVGKSTILTKLTETKSLAAAYEFTTLTCIPGVIQHKGARIQLLDTPGIIEGASQGRGRGRQVIAVARTADLILMMLDANKGEIQKRLLQEELESIGIRLNSQPPNIYFKLKSAGGVNLTATQTLTKITEKLAKSILHEYKIFNCDLVIRCDPTVDELIDAIEGRRSYIRCLYVYNKMDHMSMEDVDRLSRQPNSVVISCNMNLNLDFLLDKIWDYLNLVRVYTKLRGASPDFNDAIILREGATMEDICRFLHKELVSQFKYGIVWGVSAKHCPQRVGISHALEDEDVIQIVKK", "length": 364 }, "evidence": [ { "id": "Q58D56", "url": "https://omabrowser.org/oma/group/Q58D56/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9CAI1-1", "protein_name": "Developmentally-regulated G protein 2", "gene_name": "DRG2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGIVERIKEIEAEMARTQKNKATEYHLGQLKAKIAKLRTQLLEPPKGSSGGGDGFEVTKYGHGRVALIGFPSVGKSTLLTMLTGTHSEAASYEFTTLTCIPGVIHYNDTKIQLLDLPGIIEGASEGKGRGRQVIAVAKSSDLVLMVLDASKSEGHRQILTKELEAVGLRLNKRPPQIYFKKKKTGGISFNTTTPLTRIDEKLCYQILHEYKIHNAEVLFREDATVDDFIDVVEGNRKYIKCVYVYNKIDVVGIDDVDRLARQPNSIVISCNLKLNLDRLLARMWDEMGLVRVYSKPQSQQPDFDEPFVLSADRGGCTVEDFCNQVHRTLVKDMKYALVWGTSARHYPQHCGLFHHLEDEDVVQIVKKKVREEGGRGRFKSHSNAPARIADREKKAPLKQ", "length": 399 }, "evidence": [ { "id": "Q58D56", "url": "https://omabrowser.org/oma/group/Q58D56/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9QXB9-1", "protein_name": "Developmentally-regulated GTP-binding protein 2", "gene_name": "Drg2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGILEKISEIEKEIARTQKNKATEYHLGLLKAKLAKYRAQLLEPSKSASSKGEGFDVMKSGDARVALIGFPSVGKSTFLSLMTSTASEAASYEFTTLTCIPGVIEYKGANIQLLDLPGIIEGAAQGRGRGRQVIAVARTADVVVMMLDATKGDVQRSLLEKELESVGIRLNKHKPNIYFKPKKGGGISFNSTVTLTQCSEKLVQLILHEYKIFNAEVLFREDCSPDDFIDVIVGNRVYMPCLYVYNKIDQISMEEVDRLARKPNSVVISCGMKLNLDYLLEMLWEYLALTCIYTKKRGQRPDFTDAIILRKGASVEHVCHRIHRSLASQFKYALVWGTSTKYSPQRVGLTHTMEHEDVIQIVKK", "length": 364 }, "evidence": [ { "id": "Q58D56", "url": "https://omabrowser.org/oma/group/Q58D56/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VDV2-1", "protein_name": "Developmentally-regulated GTP-binding protein 2", "gene_name": "Dmel\\CG6195", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGILEKIAEIEREIARTQKNKATEYHLGLLKAKLAKYRSQLLEPSKKGEKGDGFDVLKSGDARVALIGFPSVGKSTMLSTLTKTESEAANYEFTTLTCIPGVIEYQGANIQLLDLPGIIEGAAQGKGRGRQVIAVARTADLVLMMLDATKPNVHRELLERELESVGIRLNKRKPNIYFKQKKGGGLSFNATCSLTRCNEKMVQTILHSFKIFNAEVLFREDCTEDEFIDVVTANRVYLPCLYVYNKIDQISIEEVDRLARQPNSIVVSCNMKLNLDYMMEALWEALQLIRVYTKKPGAPPDFDDGLILRKGVSVEHVCHAIHRTLAAQFKYALVWGTSTKYSPQRVGIAHVMADEDVIQVVKK", "length": 363 }, "evidence": [ { "id": "Q58D56", "url": "https://omabrowser.org/oma/group/Q58D56/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "Q58D56", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q58D56", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q58D56", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q58D56", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58D56", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "Q58D56", "url": "https://www.uniprot.org/uniprotkb/Q58D56" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] }, { "id": "R-BTA-9629578", "name": "JMJD7 dimer hydroxlates a lysine residue of DRG2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MEH3-1", "Q58D56-1" ], "evidence": [ { "id": "R-BTA-9629578", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9629578" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] } ] }, { "uniprot_ac": "A0AAA9S5W8", "gene_name": "RAB12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": 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"url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TNQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNQ2" } ] } ] }, { "uniprot_ac": "A0AAA9TS74", "gene_name": "RAB36", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] } ] }, { "uniprot_ac": "A0AAA9TWE6", "gene_name": "RAB35", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TWE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWE6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": 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"evidence": [ { "id": "Q58D65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D65/entry#names_and_taxonomy" } ] }, { "name": "2.5.1.114", "type": "synonym", "evidence": [ { "id": "Q58D65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D65/entry#names_and_taxonomy" } ] }, { "name": "alpha-amino-alpha-carboxypropyl transferase TYW2", "type": "synonym", "evidence": [ { "id": "NP_001019723", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019723" } ] }, { "name": "tRNA wybutosine-synthesizing protein 2 homolog", "type": "synonym", "evidence": [ { "id": "NP_001019723", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019723" } ] }, { "name": "tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase", "type": "synonym", "evidence": [ { "id": "NP_001019723", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019723" }, { "id": "Q58D65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D65/entry#names_and_taxonomy" } ] }, { "name": "tRNA-yW-synthesizing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001019723", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019723" }, { "id": "Q58D65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D65/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.", "evidence": [ { "database": "UniProtKB", "id": "Q58D65", "url": "https://www.uniprot.org/uniprotkb/Q58D65#function" }, { "database": "UniProtKB", "id": "Q53H54", "url": "https://www.uniprot.org/uniprotkb/Q53H54#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58D65", "url": "https://www.uniprot.org/uniprotkb/Q58D65" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TYW2", "url": "https://www.uniprot.org/uniprotkb/Q58D65", "locus": {} } ], "crossref": [ { "id": "Q58D65", "url": "https://alphafold.ebi.ac.uk/entry/Q58D65", "database": "AlphaFoldDB", "categories": [] }, { "id": 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"https://www.ebi.ac.uk/interpro/entry/pfam/PF25133", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001019723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019723", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "36355", "url": "https://www.rhea-db.org/rhea/36355", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58D65", "url": "https://www.uniprot.org/uniprotkb/Q58D65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58D65-1", "url": "https://www.uniprot.org/uniprotkb/Q58D65-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGAGGKPTAVVAVVTEPRFTQRYREYLEKHKLLDRQHRVKKLRDGTVALPVLREALLEQHLRELRNRVAPGSTCVPTQLLDPVPSKKAQSYSPAQRLCLEVSRWVEGRGVTWSAKLEADLPRSWQRHGDLLLLSEDCFQAKQWRHLEPELWETVASALGAQRLAKRGRVSPDSTRTPAVSLLLGDHGWVEHVDNGIRYKFDVTQCMFSFGNITEKLRVASLPCVGEVLVDLYAGIGYFTLPFLVHAEAAFVHACEWNPHAVVALRNNLELNGVADRCQIHFGDNRKLKLSNVADRVNLGLIPSSEEGWPIACRVLKQDAGGILHIHQNVESFPGKTLQPPGSSEMEEHWPSPHQIISNQLNNGATSDSRRKTLSVATKPEWQRWAKAAETRIATLLHQVHGKRWKTQILHIQPVKSYAPHVDHIVLDLECRPCHLVG", "length": 438, "header": "sp|Q58D65-1|TYW2_BOVIN Isoform 1 of tRNA wybutosine-synthesizing protein 2 homolog OS=Bos taurus OX=9913 GN=TYW2 PE=2 SV=1 CANONICAL=Q58D65-1" }, "isoforms": [ { "isoform_ac": "Q58D65-1", "url": "https://www.uniprot.org/uniprotkb/Q58D65/entry#Q58D65-1", "sequence": { "sequence": "MEGAGGKPTAVVAVVTEPRFTQRYREYLEKHKLLDRQHRVKKLRDGTVALPVLREALLEQHLRELRNRVAPGSTCVPTQLLDPVPSKKAQSYSPAQRLCLEVSRWVEGRGVTWSAKLEADLPRSWQRHGDLLLLSEDCFQAKQWRHLEPELWETVASALGAQRLAKRGRVSPDSTRTPAVSLLLGDHGWVEHVDNGIRYKFDVTQCMFSFGNITEKLRVASLPCVGEVLVDLYAGIGYFTLPFLVHAEAAFVHACEWNPHAVVALRNNLELNGVADRCQIHFGDNRKLKLSNVADRVNLGLIPSSEEGWPIACRVLKQDAGGILHIHQNVESFPGKTLQPPGSSEMEEHWPSPHQIISNQLNNGATSDSRRKTLSVATKPEWQRWAKAAETRIATLLHQVHGKRWKTQILHIQPVKSYAPHVDHIVLDLECRPCHLVG", "length": 438, "header": "sp|Q58D65-1|TYW2_BOVIN Isoform 1 of tRNA wybutosine-synthesizing protein 2 homolog OS=Bos taurus OX=9913 GN=TYW2 PE=2 SV=1 CANONICAL=Q58D65-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58D65", "url": "https://www.uniprot.org/uniprotkb/Q58D65" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:516516", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516516", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "tRNA methyltransferase activity", "id": "GO:0008175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008175", "evidence": [ { "database": "UniProtKB", "id": "Q58D65", "url": "https://www.uniprot.org/uniprotkb/Q58D65" } ], "pmid": "" }, { "name": "tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity", "id": "GO:0102522", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102522", "evidence": [ { "database": "UniProtKB", "id": "Q58D65", "url": "https://www.uniprot.org/uniprotkb/Q58D65" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58D65", "url": "https://www.uniprot.org/uniprotkb/Q58D65" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "tRNA methylation", "id": "GO:0030488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030488", "evidence": [ { "database": "UniProtKB", "id": "Q58D65", "url": "https://www.uniprot.org/uniprotkb/Q58D65" } ], "pmid": "" }, { "name": "wybutosine biosynthetic process", "id": "GO:0031591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031591", "evidence": [ { "database": "UniProtKB", "id": "Q58D65", "url": "https://www.uniprot.org/uniprotkb/Q58D65" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 212, "end_pos": 214, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "36355", "name": "", "equation": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F6RWJ0-1", "Q58D65-1" ], "evidence": [ { "id": "36355", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36355" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F6RWJ0", "gene_name": "TRMT12", "activity": [ { "ec_number": "2.5.1.114", "activity": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+).", "evidence": [ { "id": "F6RWJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWJ0" } ] }, { "ec_number": 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{ "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DC0-1", "uniprot_ac": "Q58DC0", "uniprot_id": "CPPED_BOVIN", "mass": { "chemical_mass": 35410.0, "monoisotopic_mass": 35410.0 }, "refseq": { "ac": "NP_001026941", "name": "serine/threonine-protein phosphatase CPPED1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026941" }, "gene_names": [ { "name": "CPPED1", "type": "recommended", "evidence": [ { "id": "Q58DC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC0" } ] }, { "name": "CPPED1", "type": "synonym", "evidence": [ { "id": "NP_001026941", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026941" } ] }, { "name": "CSTP1", "type": "synonym", "evidence": [ { "id": "Q58DC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC0" } ] } ], "protein_names": [ { "name": "Serine/threonine-protein phosphatase CPPED1", "type": "recommended", "evidence": [ { "id": "Q58DC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC0/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.16", "type": "synonym", "evidence": [ { "id": "Q58DC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC0/entry#names_and_taxonomy" } ] }, { "name": "Calcineurin-like phosphoesterase domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "Q58DC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC0/entry#names_and_taxonomy" } ] }, { "name": "calcineurin-like phosphoesterase domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001026941", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026941" } ] }, { "name": "serine/threonine-protein phosphatase CPPED1", "type": "synonym", "evidence": [ { "id": "NP_001026941", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026941" } ] } ], "function": [ { "annotation": "Protein phosphatase that dephosphorylates AKT family kinase 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"categories": [ "Enzyme and Pathway" ] }, { "id": "Q58DC0", "url": "https://www.orthodb.org/?gene=Q58DC0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43143", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43143", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43143:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43143:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00149", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00149", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001026941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026941", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "20629", "url": "https://www.rhea-db.org/rhea/20629", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "47004", "url": "https://www.rhea-db.org/rhea/47004", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58DC0", "url": "https://www.uniprot.org/uniprotkb/Q58DC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DC0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DC0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DC0-2", "url": "https://www.uniprot.org/uniprotkb/Q58DC0-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTAEAGGVFHRARGRTLDAFSSEKEREWKGPFYFIQGADPQFGLMKAWATGDCDNGGDEWEQEIRLAEQAVQAINKLNPKPKFFVLCGDLVHAMPGRPWRKEQTEDLQRVLRTVDSDIPLVLVSGNHDVGNVPTPETIAEFQRTWGDDYFSFWVGGVLFLVLNSQFLYDASRCPALKQEHDHWLDQQLRIAGQRACRHAVVFQHIPLFLQSIGEDDDYFNLTKSVRKEMADKFVEAGVKAVFSGHYHRNAGGTYRNLDMVVSSAIGCQLGTDTHGLRVVVVTAEKITHRYYSLDELSEKGIEDDLMDLLKEN", "length": 313, "header": "sp|Q58DC0-1|CPPED_BOVIN Isoform 1 of Serine/threonine-protein phosphatase CPPED1 OS=Bos taurus OX=9913 GN=CPPED1 PE=2 SV=1 CANONICAL=Q58DC0-1" }, "isoforms": [ { "isoform_ac": "Q58DC0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DC0/entry#Q58DC0-1", "sequence": { "sequence": "MSTAEAGGVFHRARGRTLDAFSSEKEREWKGPFYFIQGADPQFGLMKAWATGDCDNGGDEWEQEIRLAEQAVQAINKLNPKPKFFVLCGDLVHAMPGRPWRKEQTEDLQRVLRTVDSDIPLVLVSGNHDVGNVPTPETIAEFQRTWGDDYFSFWVGGVLFLVLNSQFLYDASRCPALKQEHDHWLDQQLRIAGQRACRHAVVFQHIPLFLQSIGEDDDYFNLTKSVRKEMADKFVEAGVKAVFSGHYHRNAGGTYRNLDMVVSSAIGCQLGTDTHGLRVVVVTAEKITHRYYSLDELSEKGIEDDLMDLLKEN", "length": 313, "header": "sp|Q58DC0-1|CPPED_BOVIN Isoform 1 of Serine/threonine-protein phosphatase CPPED1 OS=Bos taurus OX=9913 GN=CPPED1 PE=2 SV=1 CANONICAL=Q58DC0-1" }, "locus": {} }, { "isoform_ac": "Q58DC0-2", "url": "https://www.uniprot.org/uniprotkb/Q58DC0/entry#Q58DC0-2", "sequence": { "sequence": "MSTAEAGGVFHRARGRTLDAFSSEKEREWKGPFYFIQGADPQFGLMKAWATGDCDNGGDEWEQEIRLAEQAVQAINKLNPKPKFFVLCGDLVHAMPGRPWRKEQTEDLQRVLRTVDSDIPLVLVSGNHDVGNVPTPETIAEFQRTWGDDYFSFWVGGVLFLVLNSQFLYDASRCPALKQEHDHWLDQQLRIAGQRACRHAVVFQHIPLFLQSIGEDDDYFNLTKSVRKEMADKFVEAGTCVHAHTHKMKMPYHQRSPVPVAPCASPARTAHFSSWEPLRFSFPEKWRILSSFPALSVTWQDSSCDNCYVSFWPN", "length": 314, "header": "sp|Q58DC0-2|CPPED_BOVIN Isoform 2 of Serine/threonine-protein phosphatase CPPED1 OS=Bos taurus OX=9913 GN=CPPED1 PE=2 SV=1 CANONICAL=Q58DC0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 135, "start_aa": "Thr", "end_pos": 135, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr135", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 293, "end_pos": 293, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DC0", "url": "https://www.uniprot.org/uniprotkb/Q58DC0" } ], "site_lbl": "Ser293" }, { "start_pos": 2, "end_pos": 2, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DC0", "url": "https://www.uniprot.org/uniprotkb/Q58DC0" } ], "site_lbl": "Ser2" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DC0", "url": "https://www.uniprot.org/uniprotkb/Q58DC0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:537938", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537938", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58DC0", "url": "https://www.uniprot.org/uniprotkb/Q58DC0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q58DC0", "url": "https://www.uniprot.org/uniprotkb/Q58DC0" } ], "pmid": "" }, { "name": "protein serine/threonine phosphatase activity", "id": "GO:0004722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004722", "evidence": [ { "database": "UniProtKB", "id": "Q58DC0", "url": "https://www.uniprot.org/uniprotkb/Q58DC0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 221, "end_pos": 223, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20629", "name": "", "equation": "O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BEW5-1", "A0AAA9TV14-1", "A0AAA9S745-1", "A0A3Q1MV48-1", "F1ME76-1", "E1BAB2-1", "E1BBD9-1", "A0A3Q1N5B2-1", "F1MBQ1-1", "A0AAA9RTM1-1", "A0AAF6YJP2-1", "P48452-1", "F1MI99-1", "G3N3B3-1", "O62830-1", "Q0IIF0-1", "A5PJZ2-1", "Q17QJ3-1", "F6RRD7-1", "Q5BIP9-1", "A0AAA9TT76-1", "A6H772-1", "O62829-1", "P61287-1", "A0AAA9U0H6-1", "Q3ZBF9-1", "Q3SWW9-1", "Q3T0E7-1", "P0C591-1", "P67774-1", "Q0IID7-1", "Q0P594-1", "Q1RMV9-1", "Q2KJ36-1", "Q2PC20-1", "P79126-1", "Q17QI2-1", "Q17QM8-1", "Q2KJD7-1", "E1B9Y5-1", "Q58DC0-1", "A0AAA9SWY4-1", "A0A3Q1LZA9-1", "A0AAA9S454-1", "A0AAA9SCR0-1", "A0AAA9TD32-1", "A0A3Q1N224-1", "E1BMD4-1", "A0AAF6DLF7-1", "F1N580-1", "F1MQM7-1", "F1MW60-1", "F1N719-1", "E1BF95-1", "E1BIE7-1", "F1MEZ2-1", "F1MM08-1", "A0A3Q1MLC5-1", "A0A3Q1MH98-1", "F1MW70-1", "A0A3Q1MZU1-1" ], "evidence": [ { "id": "20629", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20629" } ] }, { "id": "47004", "name": "", "equation": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6DLF7-1", "F1MI92-1", "A0A3Q1MV48-1", "E1BEW5-1", "F1ME76-1", "E1BAB2-1", "E1BBD9-1", "A0A3Q1N5B2-1", "A0ABI0P1A3-1", "F1MBQ1-1", "A0AAA9RTM1-1", "G3N3B3-1", "A0AAF6YJP2-1", "P48452-1", "O62829-1", "Q0IIF0-1", "A5PJZ2-1", "Q17QJ3-1", "F6RRD7-1", "Q5BIP9-1", "A0AAA9TT76-1", "Q0P594-1", "A6H772-1", "O62830-1", "P61287-1", "A0AAA9U0H6-1", "Q3SWW9-1", "Q3T0E7-1", "P0C591-1", "P67774-1", "Q0IID7-1", "Q1RMV9-1", "Q2KJ36-1", "P79126-1", "Q17QI2-1", "Q17QM8-1", "Q2KJD7-1", "E1B9Y5-1", "E1BIZ2-1", "F1MI99-1", "F1MP34-1", "F1MEZ2-1", "F1MQM7-1", "F1MM08-1", "F1N719-1", "A0AAA9T455-1", "Q58DC0-1", "A0AAA9SWY4-1", "A0A3Q1LZA9-1", "A0AAA9S454-1", "A0AAA9SCR0-1", "A0AAA9TD32-1", "A0AAA9TV14-1", "A0AAA9S745-1", "F1N580-1", "E1BMD4-1", "E1BF95-1", "E1BIE7-1", "A0A3Q1N224-1", "A0A3Q1MLC5-1", "A0A3Q1MH98-1", "F1MW70-1", "A0A3Q1MZU1-1" ], "evidence": [ { "id": "47004", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47004" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LZA9", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] } ] }, { "uniprot_ac": "A0A3Q1MH98", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] } ] }, { "uniprot_ac": "A0A3Q1MLC5", "gene_name": "DUSP8", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] } ] }, { "uniprot_ac": "A0A3Q1MV48", "gene_name": "CDC14A", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] } ] }, { "uniprot_ac": "A0A3Q1MZU1", "gene_name": "CTDSPL2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MZU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZU1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MZU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZU1" } ] } ] }, { "uniprot_ac": "A0A3Q1N224", "gene_name": "PHLPP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N224", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N224" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1N224", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N224" } ] } ] }, { "uniprot_ac": "A0A3Q1N5B2", "gene_name": "CDC14B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N5B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5B2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N5B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5B2" } ] } ] }, { "uniprot_ac": "A0AAA9RTM1", "gene_name": "DUSP22", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] } ] }, { "uniprot_ac": "A0AAA9S454", "gene_name": "LOC112441581", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S454" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9S454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S454" } ] } ] }, { "uniprot_ac": "A0AAA9S745", "gene_name": "CTDSPL", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S745", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9S745", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745" } ] } ] }, { "uniprot_ac": "A0AAA9SCR0", "gene_name": "LOC112441582", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SCR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCR0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SCR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCR0" } ] } ] }, { "uniprot_ac": "A0AAA9SWY4", "gene_name": "CPPED1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] } ] }, { "uniprot_ac": "A0AAA9T455", "gene_name": "CDKN3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] } ] }, { "uniprot_ac": "A0AAA9TD32", "gene_name": "CTDP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD32" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD32" } ] } ] }, { "uniprot_ac": "A0AAA9TT76", "gene_name": "PPP3CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TT76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TT76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT76" } ] } ] }, { "uniprot_ac": "A0AAA9TV14", "gene_name": "CTDSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TV14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV14" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TV14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV14" } ] } ] }, { "uniprot_ac": "A0AAA9U0H6", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLF7", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] } ] }, { "uniprot_ac": "A0AAF6YJP2", "gene_name": "SSU72", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ] } ] }, { "uniprot_ac": "A0ABI0P1A3", "gene_name": "SSH2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0ABI0P1A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1A3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0ABI0P1A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1A3" } ] } ] }, { "uniprot_ac": "A5PJZ2", "gene_name": "PPM1L", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A5PJZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A5PJZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJZ2" } ] } ] }, { "uniprot_ac": "A6H772", "gene_name": "PPP4C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A6H772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H772" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A6H772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H772" } ] } ] }, { "uniprot_ac": "E1B9Y5", "gene_name": "PPEF2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1B9Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1B9Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y5" } ] } ] }, { "uniprot_ac": "E1BAB2", "gene_name": "", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB2" } ] } ] }, { "uniprot_ac": "E1BBD9", "gene_name": "LOC112445820", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BBD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BBD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD9" } ] } ] }, { "uniprot_ac": "E1BEW5", "gene_name": "PPTC7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BEW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW5" } ] } ] }, { "uniprot_ac": "E1BF95", "gene_name": "PPM1F", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] } ] }, { "uniprot_ac": "E1BIE7", "gene_name": "PGAM5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] } ] }, { "uniprot_ac": "E1BIZ2", "gene_name": "SSH1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] } ] }, { "uniprot_ac": "E1BMD4", "gene_name": "PHLPP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] } ] }, { "uniprot_ac": "F1MBQ1", "gene_name": "PPEF1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MI92", "gene_name": "SSH3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MW60", "gene_name": "PDXP", "activity": [ { "ec_number": "3.1.3.74", "activity": "pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.74", "activity": "", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] } ] }, { "uniprot_ac": "F1N580", "gene_name": "PPM1E", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] } ] }, { "uniprot_ac": "F1N719", "gene_name": "PPP5C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] } ] }, { "uniprot_ac": "F6RRD7", "gene_name": "RPAP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] } ] }, { "uniprot_ac": "G3N3B3", "gene_name": "PPM1N", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] } ] }, { "uniprot_ac": "O62829", "gene_name": "PPM1A", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] } ] }, { "uniprot_ac": "O62830", "gene_name": "PPM1B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] } ] }, { "uniprot_ac": "P0C591", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] } ] }, { "uniprot_ac": "P48452", "gene_name": "PPP3CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] } ] }, { "uniprot_ac": "P61287", "gene_name": "PPP1CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] } ] }, { "uniprot_ac": "P67774", "gene_name": "PPP2CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] } ] }, { "uniprot_ac": "P79126", "gene_name": "PPM1G", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] } ] }, { "uniprot_ac": "Q0IID7", "gene_name": "DUSP10", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] } ] }, { "uniprot_ac": "Q0IIF0", "gene_name": "ILKAP", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IIF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIF0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IIF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIF0" } ] } ] }, { "uniprot_ac": "Q0P594", "gene_name": "PPP2CB", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] } ] }, { "uniprot_ac": "Q17QI2", "gene_name": "SSU72", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI2" } ] } ] }, { "uniprot_ac": "Q17QJ3", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": 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"MAYYSARLRTRQTYSWVGRPLLDQKLHYQTYKEMSMKREDYSTEIHIQVGQFVLIEGDDDENPYVAKLVELFEDDSELYSKKRARVQWFIRFCEVPVCKQHLLGRKPGTQEIFWYDNPTCNSNISVETIIGSVRVVALAPDEVMPIDLKNKKTFFVKLSWNEKKFKPLPPEVFAQLNKLQEDNHRYQKPMQAKTKSAESPSWTTTEHAVKRIESRHSTSKSRHTASHPVTPRARKRLELSSFPRTPNTRISPAASCASLDSPGRMKRKVAFSEVMSPSKRSLPDGFQTSSPALKAPEKTGEIQHSCTKDAKKTSPDHGMILRARAPALKITETSEERTLTPIGGGRKSSVVPSVILKPEYIKRREGKEPEVQDEAPSTSRIRRKSSVLTLNRIRQQLRFLGNSKSDENDEEFLPAAEISDCDSEEEEASTTPLPRRTPNSVSRNLRSSMKSSLQTPSKTPKKTPEPRTPRDATPRIRSRNLTAQGPTNMLEEARLRLHVAAVPESLPCREQEFQDIYNFVESKLLDQTGGCMYISGVPGTGKTATVHEVICCLQQAAQANEVPPFQYIEVNGMKLTEPHQVYVQILQKLTGKRATANHAAALLAKRFCTQGSSQETTVLLVDELDLLWTQKQDVMYNLFDWPTHKEARLVVLTIANTMDLPERIMMNRVSSRLGLTRMCFQPYTHSQLRQILLSRLRHVKAFEDDAIQLVARKVAALSGDARRCLDICRRATEICEFSCQKPDSPGLVTTAHLLEAIDEMFSSSYITAIKNSSVLEQSFLRAILAEFRRSGLEEATFQQVYIQHVALCRMEGLPYPTMSETMAVCSRLGACRLLLVEPSRNDVLRRVRLNVSQDDVLYALKEE", "length": 863, "header": "sp|Q58DC8-1|ORC1_BOVIN Isoform 1 of Origin recognition complex subunit 1 OS=Bos taurus OX=9913 GN=ORC1 PE=2 SV=2 CANONICAL=Q58DC8-1" }, "isoforms": [ { "isoform_ac": "Q58DC8-1", "url": "https://www.uniprot.org/uniprotkb/Q58DC8/entry#Q58DC8-1", "sequence": { "sequence": "MAYYSARLRTRQTYSWVGRPLLDQKLHYQTYKEMSMKREDYSTEIHIQVGQFVLIEGDDDENPYVAKLVELFEDDSELYSKKRARVQWFIRFCEVPVCKQHLLGRKPGTQEIFWYDNPTCNSNISVETIIGSVRVVALAPDEVMPIDLKNKKTFFVKLSWNEKKFKPLPPEVFAQLNKLQEDNHRYQKPMQAKTKSAESPSWTTTEHAVKRIESRHSTSKSRHTASHPVTPRARKRLELSSFPRTPNTRISPAASCASLDSPGRMKRKVAFSEVMSPSKRSLPDGFQTSSPALKAPEKTGEIQHSCTKDAKKTSPDHGMILRARAPALKITETSEERTLTPIGGGRKSSVVPSVILKPEYIKRREGKEPEVQDEAPSTSRIRRKSSVLTLNRIRQQLRFLGNSKSDENDEEFLPAAEISDCDSEEEEASTTPLPRRTPNSVSRNLRSSMKSSLQTPSKTPKKTPEPRTPRDATPRIRSRNLTAQGPTNMLEEARLRLHVAAVPESLPCREQEFQDIYNFVESKLLDQTGGCMYISGVPGTGKTATVHEVICCLQQAAQANEVPPFQYIEVNGMKLTEPHQVYVQILQKLTGKRATANHAAALLAKRFCTQGSSQETTVLLVDELDLLWTQKQDVMYNLFDWPTHKEARLVVLTIANTMDLPERIMMNRVSSRLGLTRMCFQPYTHSQLRQILLSRLRHVKAFEDDAIQLVARKVAALSGDARRCLDICRRATEICEFSCQKPDSPGLVTTAHLLEAIDEMFSSSYITAIKNSSVLEQSFLRAILAEFRRSGLEEATFQQVYIQHVALCRMEGLPYPTMSETMAVCSRLGACRLLLVEPSRNDVLRRVRLNVSQDDVLYALKEE", "length": 863, "header": "sp|Q58DC8-1|ORC1_BOVIN Isoform 1 of Origin recognition complex subunit 1 OS=Bos taurus OX=9913 GN=ORC1 PE=2 SV=2 CANONICAL=Q58DC8-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 817, "start_aa": "Thr", "end_pos": 817, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr817", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 199, "end_pos": 199, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DC8", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" } ], "site_lbl": "Ser199" }, { "start_pos": 203, "end_pos": 203, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q58DC8", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" } ], "site_lbl": "Thr203" }, { "start_pos": 255, "end_pos": 255, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DC8", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" } ], "site_lbl": "Ser255" }, { "start_pos": 258, "end_pos": 258, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DC8", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" } ], "site_lbl": "Ser258" }, { "start_pos": 276, "end_pos": 276, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DC8", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" } ], "site_lbl": "Ser276" }, { "start_pos": 290, "end_pos": 290, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DC8", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" } ], "site_lbl": "Ser290" }, { "start_pos": 340, "end_pos": 340, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q58DC8", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" } ], "site_lbl": "Thr340" }, { "start_pos": 419, "end_pos": 419, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DC8", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" } ], "site_lbl": "Ser419" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DC8", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:513523", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513523", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA replication origin binding", "id": "GO:0003688", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003688", "evidence": [ { "database": "UniProtKB", "id": "Q58DC8", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "Q58DC8", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q58DC8", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q58DC8", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q58DC8", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA replication initiation", "id": "GO:0006270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006270", "evidence": [ { "database": "UniProtKB", "id": "Q58DC8", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" } ], "pmid": "" }, { "name": "mitotic DNA replication checkpoint signaling", "id": "GO:0033314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033314", "evidence": [ { "database": "UniProtKB", "id": "Q58DC8", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear origin of replication recognition complex", "id": "GO:0005664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005664", "evidence": [ { "database": "UniProtKB", "id": "Q58DC8", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 480, "end_pos": 482, "annotation": "n_glycosylation_sequon" }, { "start_pos": 771, "end_pos": 773, "annotation": "n_glycosylation_sequon" }, { "start_pos": 850, "end_pos": 852, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DC8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 863, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DC8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DC8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q58DC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" }, { "id": "PRU00370", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00370" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BAH", "eco_id": "ECO_0000255", "start_pos": 45, "end_pos": 171, "start_aa": "Ile", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "Q58DC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC8#function" }, { "id": "Q58DC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" } ], "binding_site_uniprot": 622, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 622, "end_pos": 622, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q58DC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC8#function" }, { "id": "Q58DC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC8" } ], "binding_site_uniprot": 623, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 623, "end_pos": 623, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 817 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 199, 203, 255, 258, 276, 290, 340, 419 ], "sequon_annotation_sites": [ { "start_pos": 123, "end_pos": 125 }, { "start_pos": 480, "end_pos": 482 }, { "start_pos": 771, "end_pos": 773 }, { "start_pos": 850, "end_pos": 852 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 8 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DG1-1", "uniprot_ac": "Q58DG1", "uniprot_id": "MYG1_BOVIN", "mass": { "chemical_mass": 42967.0, "monoisotopic_mass": 42967.0 }, "refseq": {}, "gene_names": [ { "name": "MYG1", "type": "recommended", "evidence": [ { "id": "Q58DG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DG1" } ] } ], "protein_names": [ { "name": "MYG1 exonuclease", "type": "recommended", "evidence": [ { "id": "Q58DG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DG1/entry#names_and_taxonomy" } ] }, { "name": "3.1.-.-", "type": "synonym", "evidence": [ { "id": "Q58DG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DG1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk. In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins.", "evidence": [ { "database": "UniProtKB", "id": "Q58DG1", "url": "https://www.uniprot.org/uniprotkb/Q58DG1#function" }, { "database": "UniProtKB", "id": "Q9HB07", "url": "https://www.uniprot.org/uniprotkb/Q9HB07#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DG1", "url": "https://www.uniprot.org/uniprotkb/Q58DG1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYG1", "url": "https://www.uniprot.org/uniprotkb/Q58DG1", "locus": { "chromosome": "5", "start_pos": 26712725, "end_pos": 26724283, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020177", "url": "https://www.ensembl.org/id/ENSBTAG00000020177" } ] } } ], "crossref": [ { "id": "Q58DG1", "url": "https://alphafold.ebi.ac.uk/entry/Q58DG1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020177", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020177", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003226", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003226", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FHCDEVV", "url": "https://omabrowser.org/oma/group/FHCDEVV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11215", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11215", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11215:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11215:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q58DG1", "url": "https://www.uniprot.org/uniprotkb/Q58DG1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DG1-1", "url": "https://www.uniprot.org/uniprotkb/Q58DG1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGHRFLRGFLRVLLPPLPLRSPHLKLSLEPVAPSKRPRSHLMAPPRIGTHNGTFHCDEALACALLRLLPEYREAEIVRTRDPEKLAACDIVVDVGGEYDPQRHRYDHHQRSFTETMSSLSPGKPWQTKLSSAGLIYLHFGHKLLAQLLGTSEEDGMVGTLYDKMYENFVEEVDAVDNGISQWEEGEPRYLLTTTLSARVARLNPTWNQPNQDTEAGFKRAMDLVREEFLQRLDFYQNSWLPARTLVEEALAKRFQVDPSGEIIELEKGGCPWKEHLYQLELGLSPAGTIAFVIYTDQAGQWRVQCVPKEPHSFQSRLPLLEPWRGLRDEALDQISGIPGCIFVHASGFIGGHRTREGALSMARATLAQRPAPTPAPNPMVQ", "length": 381, "header": "sp|Q58DG1-1|MYG1_BOVIN Isoform 1 of MYG1 exonuclease OS=Bos taurus OX=9913 GN=MYG1 PE=2 SV=1 CANONICAL=Q58DG1-1" }, "isoforms": [ { "isoform_ac": "Q58DG1-1", "url": "https://www.uniprot.org/uniprotkb/Q58DG1/entry#Q58DG1-1", "sequence": { "sequence": "MGHRFLRGFLRVLLPPLPLRSPHLKLSLEPVAPSKRPRSHLMAPPRIGTHNGTFHCDEALACALLRLLPEYREAEIVRTRDPEKLAACDIVVDVGGEYDPQRHRYDHHQRSFTETMSSLSPGKPWQTKLSSAGLIYLHFGHKLLAQLLGTSEEDGMVGTLYDKMYENFVEEVDAVDNGISQWEEGEPRYLLTTTLSARVARLNPTWNQPNQDTEAGFKRAMDLVREEFLQRLDFYQNSWLPARTLVEEALAKRFQVDPSGEIIELEKGGCPWKEHLYQLELGLSPAGTIAFVIYTDQAGQWRVQCVPKEPHSFQSRLPLLEPWRGLRDEALDQISGIPGCIFVHASGFIGGHRTREGALSMARATLAQRPAPTPAPNPMVQ", "length": 381, "header": "sp|Q58DG1-1|MYG1_BOVIN Isoform 1 of MYG1 exonuclease OS=Bos taurus OX=9913 GN=MYG1 PE=2 SV=1 CANONICAL=Q58DG1-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 373, "start_aa": "Thr", "end_pos": 373, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr373", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 120, "end_pos": 120, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DG1", "url": "https://www.uniprot.org/uniprotkb/Q58DG1" } ], "site_lbl": "Ser120" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DG1", "url": "https://www.uniprot.org/uniprotkb/Q58DG1" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A140LG01-1", "protein_name": "MYG1 exonuclease", "gene_name": "myg1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTHAHTASPVRLAALQRRQSSSRGSSSSRNHQMRVCSRLLSSVLINKHHLMKMKMKIGTHNGTFHCDEVLACFLLRQLPEYKDAEIVRSRDASVLAECDVVVDVGGEYDHSRQRYDHHQRAFAESFHSVCAQKPWVTKLSSAGLVYVHYGRRVLQQLTHLQEDEPQLEVLYDKMYEGFVEEVDAVDNGISQSDGEQRYTISSTISSRVSYLNPQWNSKEQDTEEGFRKALALVGSEFQDRLLYFTNAWLPARDVVLQAIKSRHQVDVSGQVLLLQQGGCPWKEHLFALEKELQLQELIKFVLYCDQNGHWRVQCVPAGPNTFQNRLSLLEEWRGLRDDALSELSGIPECIFVHAGGFIGGNKTQSGALEMARRTLQTAPTH", "length": 381 }, "evidence": [ { "id": "Q58DG1", "url": "https://omabrowser.org/oma/group/Q58DG1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A287A0Y1-1", "protein_name": "MYG1 exonuclease", "gene_name": "MYG1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGHRFLRGLLPLLLPLPPVPTLWGPHRTLSLEFVLPSKRPRSHLMAPPRIGTHNGTFHCDEALACALLRLLPEYRDAEIVRTRDPEKLASCDIVVDVGGEYDPQRHRYDHHQRSFTETMSSLSPGKPWQTKLSSAGLIYLHFGHKLLAQLLGTSEEDSVVGILYDKMYENFVEEVDAVDNGIAQWEEGEPRYALTTTLSARVARLNPTWNQPNQDTEAGFKRAMDLVREEFLQRLDFYQHSWLPARALVEEALAQRFQVDASGKIIELAKGGCPWKEHLYHLELDLSPPVAISFVIYTDQAGQWRVQCVPKELHSFQSRLPLPEPWRGLRDEALDQVSGIPGCVFVHASGFIGGHRTREGALSMARTTLALHSAPLPPTNPLGQ", "length": 384 }, "evidence": [ { "id": "Q58DG1", "url": "https://omabrowser.org/oma/group/Q58DG1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZZL9-1", "protein_name": "MYG1 exonuclease", "gene_name": "C12orf10", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRAALRAVPLMAAAVAGSGAGPKRARTEPPLRIGTHDGTFHCDEALACYLLRLLPRYRPHPIAQQDAEVVRTRDPQRLAQCDVVVDVGGEYDPERHRYDHHQRSFTQSMQSLQPSKPWTTKLSSAGLVYCHFGSEILAGLLGQPEDSPAVTALYDKLYENFVEEIDAIDNGIAQTDGEPRYALTTNLSARVGHLNPRWNDPDQDTEAGFKRAMELVGSEFMDRLDYYHRAWLPARALVEDAIRRRFEVDTSGVLLELPQGGCPWKEHLFSLEKELVLPDPLQLVLFPDRSGQWRVQSVPVGPRSFESRLPLPEPWRGVRDEALSQLTGIPGCVFVHSSGFIGGNRTREGALEMARRTLALQGVGAQSG", "length": 368 }, "evidence": [ { "id": "Q58DG1", "url": "https://omabrowser.org/oma/group/Q58DG1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F4K000-1", "protein_name": "Metal-dependent protein hydrolase", "gene_name": "MJC20.7", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MMFSVTKGLIRNLALFQVRLPPLVAAVMAPSSVVRVYSTATSPSPSEISVKKVGTHNGSFHCDEALGCFMIRLVDKFSGADIVRSRDPKILAELDAVLDVGGVYDPEHDRYDHHQKGFEEVFGHGFNTKLSSAGLVYKHFGKEIIAKELNVEQDHPDVLRLFLAVYKSFMEAIDAVDNGINRYDTDQPPRYVNNTHLSPRVGRLNLDWIDPDQSQEKENEAFQRAMALAGKEFLESVQFHARSWLPARSIVMQCLEERFKTDPSGEIMILDRFCPWKLHLFELEQEMKIEPLIKYVIYQDERAKQWRVQAVAVAPDRFENRKPLPEKWRGLRDEELSKAAEIPGCVFVHMSGFIGGNQSYDGALSMAQTALTL", "length": 373 }, "evidence": [ { "id": "Q58DG1", "url": "https://omabrowser.org/oma/group/Q58DG1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "G3HV49-1", "protein_name": "MYG1 exonuclease isoform X1", "gene_name": "Myg1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGCFLRDILTVLLPLRSLLQTQRRMLGSESVSPPKRPRSNLMAPPRIGTHNGTFHCDEALACALLRLLPEYKDAEIVRTRDPEKLASCDIVVDVGGEYNPLRHRYDHHQRTFTETMSSLCPGKPWQTKLSSAGLVYLHFGHKLLAQLLGTSEEDSIVDTLYDKMYENFVEEVDAVDNGISQWEEGEPRYALTTTLSARVSRLNPTWNQPNQDTEAGFRRAMDLVQEEFLQRLNFYQHSWLPARALVEEALAQRFQVDSSGKIVELAKGGCPWKEHLYHLESELSPPVAITFVIYTDQAGQWRVQCVPKEPHSFQSRLPLPEPWRGLRDEALDQVSGIPGCIFVHASGFIGGHRTREGALNMARATLAQHPAPTPLANAVVK", "length": 381 }, "evidence": [ { "id": "Q58DG1", "url": "https://omabrowser.org/oma/group/Q58DG1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P40093-1", "protein_name": "MYG1 protein YER156C", "gene_name": "", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MNSVKRVKLNSKMSKQICTHSGSFHADESLAVYMLRLLPEFKDAKLVRSRNPKDWEASDILVDVGAQYDGVKFFDHHQRGFFETFNEKYKTKLSSAGLIFKHYGRDIIKTILNNKVSSSDLDLLYDKVYKQFVEALDANDNGISKYTIPKDSNLEPNFRDNAISIPGIISGMNPNWNEDTSDESFDRCFARASEFIGGVFVTLVRGYGQSWLPAKALVAQAIDERMDVDKSGKIIVLPQFCPWKEHLYELEREKNIEKQIEFVLFTDSSGAWRVSTVPINSTSFQFRRGLPEPLRGLRDEELSTKSGVPGCIFIHAAGFIGGAKSKEAVYELAKMSLA", "length": 338 }, "evidence": [ { "id": "Q58DG1", "url": "https://omabrowser.org/oma/group/Q58DG1/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q55G91-1", "protein_name": "MYG1 protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSDLTICTHSGSFHADEALACYLLKLLPTYKDSKIIRSRDKSVIEKSTVAVDVGAVYNFEKLRFDHHQSGFTETFDDKHDIKLSSAGLIYKHYGKDIIKQRLDTNDSITELLYQKLYDSMIQELDGVDNGVERYPSDIKPRYQSGSSISARVGHLNQGWNEPQDDEIVNKQFEKAMELMGQYFLDRLDYYGKSWLPCRSIVENALENRKQTHSSGEILILDMFCPWKDHLFSLEQEKDIKTPIKFVLFEDTSGQWRVSAVGINLHSFTLRLPLPEEWRGKRDEELSQISGIEGCVFAHANGFIGGNKTREGALLMAIKTLNQSPKTLLE", "length": 329 }, "evidence": [ { "id": "Q58DG1", "url": "https://omabrowser.org/oma/group/Q58DG1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q641W2-1", "protein_name": "MYG1 exonuclease", "gene_name": "Myg1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGRGFLRGVLTLLPLRSVLQVQHCMLVSEPDLPPKRPRNNLMAPPRIGTHNGTFHCDEALACALLRLLPEYRNAEIVRTRDPEKLALCDIVVDVGGEYNPQRHRYDHHQRTFTETMSSLCPGKPWQTKLSSAGLVYLHFGHKLLAQLLGTSEEDSVVDTIYDKMYENFVEEVDAVDNGISQWAEGEPRYALTTTLSARVSRLNPTWNQPDQDTEAGFRRAMDLVQEEFLQRLNFYQHSWLPARALVEEALAQRFKVDSSGEIVELAKGGCPWKEHLYHLESELSPTVAITFVIYTDQAGQWRVQCVPKEPHSFQSRLPLPEPWRGLRDEALDQVSGIPGCIFVHASGFIGGHHTREGALNMARATLAQRTAPVPLANAVVQ", "length": 381 }, "evidence": [ { "id": "Q58DG1", "url": "https://omabrowser.org/oma/group/Q58DG1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8INP9-1", "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG11980", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFRLLPRFPGKLSIMTGVTPPKRSPLWIGTHSGTFHCDELVACFMLKQLDEYKNAEIFRSRDNKALKEKCDIIVDVGGVYDHAKKLYDHHQITFKETFSSVRPDVSEDYNVVRLSSAGLVYCHYGERVIQSILQREKGIKLSPENLQTAFIQIYRNFINELDAIDNGVPMFEGVEPIYKISTHLSARIAKLNPSWQETGVDIEDRFRQAMDTAGREFVDNVVEVSCSWIPARDHVREALKNAKNVHPTGEILVLKNFCPWKSHLFDLEKEYKVEGVPKLVVFNSGNSWRVAGVPVTPGSYLGRKFLPTPWRGLMDDELCDKASIKDLEFIHHTGFIGGAKTEEAAMLLAKKSTEWTEEQ", "length": 359 }, "evidence": [ { "id": "Q58DG1", "url": "https://omabrowser.org/oma/group/Q58DG1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9HB07-1", "protein_name": "MYG1 exonuclease", "gene_name": "MYG1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGHRFLRGLLTLLLPPPPLYTRHRMLGPESVPPPKRSRSKLMAPPRIGTHNGTFHCDEALACALLRLLPEYRDAEIVRTRDPEKLASCDIVVDVGGEYDPRRHRYDHHQRSFTETMSSLSPGKPWQTKLSSAGLIYLHFGHKLLAQLLGTSEEDSMVGTLYDKMYENFVEEVDAVDNGISQWAEGEPRYALTTTLSARVARLNPTWNHPDQDTEAGFKRAMDLVQEEFLQRLDFYQHSWLPARALVEEALAQRFQVDPSGEIVELAKGACPWKEHLYHLESGLSPPVAIFFVIYTDQAGQWRIQCVPKEPHSFQSRLPLPEPWRGLRDEALDQVSGIPGCIFVHASGFIGGHRTREGALSMARATLAQRSYLPQIS", "length": 376 }, "evidence": [ { "id": "Q58DG1", "url": "https://omabrowser.org/oma/group/Q58DG1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JK81-1", "protein_name": "MYG1 exonuclease", "gene_name": "Myg1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGRRFLRGILTLPLRSVLQAQHRMLGSEQDPPAKRPRNNLMAPPRIGTHNGTFHCDEALACALLRLLPEYANAEIVRTRDPEKLASCDIVVDVGGEYNPQSHRYDHHQRTFTETMSSLCPGKPWQTKLSSAGLVYLHFGRKLLAQLLGTSEEDSVVDTIYDKMYENFVEEVDAVDNGISQWAEGEPRYAMTTTLSARVARLNPTWNQPNQDTEAGFRRAMDLVQEEFLQRLNFYQHSWLPARALVEEALAQRFKVDSSGEIVELAKGGCPWKEHLYHLESELSPKVAITFVIYTDQAGQWRVQCVPKEPHSFQSRLPLPEPWRGLRDKALDQVSGIPGCIFVHASGFIGGHHTREGALNMARATLAQRPAPVPLANAVVQ", "length": 380 }, "evidence": [ { "id": "Q58DG1", "url": "https://omabrowser.org/oma/group/Q58DG1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q58DG1", "url": "https://www.uniprot.org/uniprotkb/Q58DG1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q58DG1", "url": "https://www.uniprot.org/uniprotkb/Q58DG1" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q58DG1", "url": "https://www.uniprot.org/uniprotkb/Q58DG1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58DG1", "url": "https://www.uniprot.org/uniprotkb/Q58DG1" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q58DG1", "url": "https://www.uniprot.org/uniprotkb/Q58DG1" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q58DG1", "url": "https://www.uniprot.org/uniprotkb/Q58DG1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "Q58DG1", "url": "https://www.uniprot.org/uniprotkb/Q58DG1" } ], "pmid": "" }, { "name": "nuclease activity", "id": "GO:0004518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004518", "evidence": [ { "database": "UniProtKB", "id": "Q58DG1", "url": "https://www.uniprot.org/uniprotkb/Q58DG1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DG1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 381, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DG1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DG1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 373 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 120 ], "sequon_annotation_sites": [ { "start_pos": 51, "end_pos": 53 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DH1-1", "uniprot_ac": "Q58DH1", "uniprot_id": "XAF1_BOVIN", "mass": { "chemical_mass": 33687.0, "monoisotopic_mass": 33687.0 }, "refseq": { "ac": "NP_001030247", "name": "XIAP-associated factor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030247" }, "gene_names": [ { "name": "XAF1", "type": "recommended", "evidence": [ { "id": "Q58DH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DH1" } ] }, { "name": "BIRC4BP", "type": "synonym", "evidence": [ { "id": "NP_001030247", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030247" } ] }, { "name": "HSXIAPAF1", "type": "synonym", "evidence": [ { "id": "NP_001030247", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030247" } ] }, { "name": "XAF1", "type": "synonym", "evidence": [ { "id": "NP_001030247", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030247" } ] } ], "protein_names": [ { "name": "XIAP-associated factor 1", "type": "recommended", "evidence": [ { "id": "Q58DH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DH1/entry#names_and_taxonomy" } ] }, { "name": "XIAP-associated factor 1", "type": "synonym", "evidence": [ { "id": "NP_001030247", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030247" } ] } ], "function": [ { "annotation": "Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q58DH1", "url": "https://www.uniprot.org/uniprotkb/Q58DH1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DH1", "url": "https://www.uniprot.org/uniprotkb/Q58DH1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "XAF1", "url": "https://www.uniprot.org/uniprotkb/Q58DH1", "locus": { "chromosome": "19", "start_pos": 25148651, "end_pos": 25180285, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011343", "url": "https://www.ensembl.org/id/ENSBTAG00000011343" } ] } } ], "crossref": [ { "id": "Q58DH1", "url": "https://alphafold.ebi.ac.uk/entry/Q58DH1", "database": "AlphaFoldDB", "categories": [] }, { "id": "509740", "url": "https://www.ncbi.nlm.nih.gov/gene/509740", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031220", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031220", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041386", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041386", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051986", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051986", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509740", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509740", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58DH1", "url": "https://www.orthodb.org/?gene=Q58DH1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16295", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16295", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16295:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16295:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF18608", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18608", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21366", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21366", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030247", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58DH1", "url": "https://www.uniprot.org/uniprotkb/Q58DH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DH1-1", "url": "https://www.uniprot.org/uniprotkb/Q58DH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DH1-2", "url": "https://www.uniprot.org/uniprotkb/Q58DH1-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGALQVCRNCKRRVASNHLGLHEAHCLMYLVLCPECKEPVLQHEMEEHCQGGHQQVGCAMCQQSVPKHSLDSHEAQECQERPVECQFCQLAVRLNKVDLHEHHCGQQTELCPDCGQHVMLRVLARHREECQREQLRLQKGKSIPVPESNICCHYCNQMIPGNKYFHHLDRCRRVSGAVTPSPVGKPEIPPSSPLSWAAEDQTSKAEKDVRPKLKNRHRAPFLSEKSTRQAPRGTNKTTNLSLKSNGKLRASSPVEDETAYDILRRCSQCDILLPLPTLNHHQEKCRRLASSKGKQV", "length": 297, "header": "sp|Q58DH1-1|XAF1_BOVIN Isoform 1 of XIAP-associated factor 1 OS=Bos taurus OX=9913 GN=XAF1 PE=2 SV=2 CANONICAL=Q58DH1-1" }, "isoforms": [ { "isoform_ac": "Q58DH1-1", "url": "https://www.uniprot.org/uniprotkb/Q58DH1/entry#Q58DH1-1", "sequence": { "sequence": "MEGALQVCRNCKRRVASNHLGLHEAHCLMYLVLCPECKEPVLQHEMEEHCQGGHQQVGCAMCQQSVPKHSLDSHEAQECQERPVECQFCQLAVRLNKVDLHEHHCGQQTELCPDCGQHVMLRVLARHREECQREQLRLQKGKSIPVPESNICCHYCNQMIPGNKYFHHLDRCRRVSGAVTPSPVGKPEIPPSSPLSWAAEDQTSKAEKDVRPKLKNRHRAPFLSEKSTRQAPRGTNKTTNLSLKSNGKLRASSPVEDETAYDILRRCSQCDILLPLPTLNHHQEKCRRLASSKGKQV", "length": 297, "header": "sp|Q58DH1-1|XAF1_BOVIN Isoform 1 of XIAP-associated factor 1 OS=Bos taurus OX=9913 GN=XAF1 PE=2 SV=2 CANONICAL=Q58DH1-1" }, "locus": {} }, { "isoform_ac": "Q58DH1-2", "url": "https://www.uniprot.org/uniprotkb/Q58DH1/entry#Q58DH1-2", "sequence": { "sequence": "MEGALQVCRNCKRRVASNHLGLHEAHCLMYLVLCPECKEPVLQHEMEEHCQGGHQQVGCAMCQQSVPKHSLDSHEAQECQERPVECQFCQLAVRLNKVDLHEHHCGQQTELCPDCGQHVMLRVLARHREECQREQLRLQKGKSIPVPESNICCHYCNQMIPGNKYFHHLDRCRRVSGAVTPSPVGKPEIPPSSPLSWAAEDQTSKAEKDVRPKLKNRHRAPFLSEKSTRQAPRGTNKTTNLSLKSNGKLRASSPVEDETAYDILRRCSQCDILLPLPTLNHHQRCWFAQELQLNQEEKRTPTLLPENSDQASRPNPAWTPWEIQLYL", "length": 327, "header": "sp|Q58DH1-2|XAF1_BOVIN Isoform 2 of XIAP-associated factor 1 OS=Bos taurus OX=9913 GN=XAF1 PE=2 SV=2 CANONICAL=Q58DH1-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 180, "start_aa": "Thr", "end_pos": 180, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr180", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DH1", "url": "https://www.uniprot.org/uniprotkb/Q58DH1" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:509740", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509740", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q58DH1", "url": "https://www.uniprot.org/uniprotkb/Q58DH1" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q58DH1", "url": "https://www.uniprot.org/uniprotkb/Q58DH1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q58DH1", "url": "https://www.uniprot.org/uniprotkb/Q58DH1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q58DH1", "url": "https://www.uniprot.org/uniprotkb/Q58DH1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 236, "end_pos": 238, "annotation": "n_glycosylation_sequon" }, { "start_pos": 240, "end_pos": 242, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DH1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 297, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DH1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DH1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 180 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 236, "end_pos": 238 }, { "start_pos": 240, "end_pos": 242 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DL1-1", "uniprot_ac": "Q58DL1", "uniprot_id": "ARGI2_BOVIN", "mass": { "chemical_mass": 38616.0, "monoisotopic_mass": 38616.0 }, "refseq": {}, "gene_names": [ { "name": "ARG2", "type": "recommended", "evidence": [ { "id": "Q58DL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DL1" } ] } ], "protein_names": [ { "name": "Arginase-2, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q58DL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DL1/entry#names_and_taxonomy" } ] }, { "name": "3.5.3.1", "type": "synonym", "evidence": [ { "id": "Q58DL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DL1/entry#names_and_taxonomy" } ] }, { "name": "Arginase II", "type": "synonym", "evidence": [ { "id": "Q58DL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DL1/entry#names_and_taxonomy" } ] }, { "name": "Type II arginase", "type": "synonym", "evidence": [ { "id": "Q58DL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DL1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction. Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling. 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"CD53 antigen", "type": "synonym", "evidence": [ { "id": "NP_001029404", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029404" } ] }, { "name": "Cell surface glycoprotein CD53", "type": "synonym", "evidence": [ { "id": "Q58DM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DM3/entry#names_and_taxonomy" } ] }, { "name": "cell surface glycoprotein CD53", "type": "synonym", "evidence": [ { "id": "NP_001029404", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029404" } ] }, { "name": "leukocyte surface antigen CD53", "type": "synonym", "evidence": [ { "id": "NP_001029404", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029404" } ] } ], "function": [ { "annotation": "Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Plays a role in the activation of monocytes and B-cells (By similarity). Acts as an essential regulator of B-cell development by promoting interleukin-7 receptor/IL7R signaling (By similarity). Also promotes, in B-cells, the BCR signaling by recruiting PKC to the plasma membrane in order to phosphorylate its substrates (By similarity). Plays an essential role in B- and T-cells homing to lymph nodes by stabilizing L-selectin/SELL cell surface expression (By similarity). Also mediates metabolic and inflammatory functions in hepatocytes and adipose tissue by promoting TNF and LPS signaling independent of the immune compartment (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q58DM3", "url": "https://www.uniprot.org/uniprotkb/Q58DM3#function" }, { "database": "UniProtKB", "id": "P19397", "url": "https://www.uniprot.org/uniprotkb/P19397#function" }, { "database": "UniProtKB", "id": "Q61451", "url": "https://www.uniprot.org/uniprotkb/Q61451#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DM3", "url": "https://www.uniprot.org/uniprotkb/Q58DM3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CD53", "url": "https://www.uniprot.org/uniprotkb/Q58DM3", "locus": { "chromosome": "3", "start_pos": 32494133, "end_pos": 32532949, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006466", "url": "https://www.ensembl.org/id/ENSBTAG00000006466" } ] } } ], "crossref": [ { "id": "Q58DM3", "url": "https://alphafold.ebi.ac.uk/entry/Q58DM3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006466", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006466", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505040", "url": "https://www.ncbi.nlm.nih.gov/gene/505040", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018503", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018503", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505040", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505040", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IQSFLHC", "url": "https://omabrowser.org/oma/group/IQSFLHC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DM3", "url": "https://www.orthodb.org/?gene=Q58DM3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282:SF39", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282:SF39", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00335", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00335", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001029404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029404", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58DM3", "url": "https://www.uniprot.org/uniprotkb/Q58DM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DM3-1", "url": "https://www.uniprot.org/uniprotkb/Q58DM3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGMSSLKLLKFVLFFFNLIFWFCGCCILGLGIYLLIHSKFGVLFHNLPSLTLGNVLVIVGSVIMVVAFLGCMGSIKENKCLLMSFFVLLLIILLAEVTLAILLFVYEQKLKEYVAEGLTESIQRYNSDNSTKAAWDSIQSFLQCCGVNGTSDWTSGPPASCPKGSAVKGCYIQAKQWFHSNFLYIGITTICVCVIQVLGMSFALTLNCQIDKTSQVLGL", "length": 219, "header": "sp|Q58DM3-1|CD53_BOVIN Isoform 1 of Leukocyte surface antigen CD53 OS=Bos taurus OX=9913 GN=CD53 PE=2 SV=1 CANONICAL=Q58DM3-1" }, "isoforms": [ { "isoform_ac": "Q58DM3-1", "url": "https://www.uniprot.org/uniprotkb/Q58DM3/entry#Q58DM3-1", "sequence": { "sequence": "MGMSSLKLLKFVLFFFNLIFWFCGCCILGLGIYLLIHSKFGVLFHNLPSLTLGNVLVIVGSVIMVVAFLGCMGSIKENKCLLMSFFVLLLIILLAEVTLAILLFVYEQKLKEYVAEGLTESIQRYNSDNSTKAAWDSIQSFLQCCGVNGTSDWTSGPPASCPKGSAVKGCYIQAKQWFHSNFLYIGITTICVCVIQVLGMSFALTLNCQIDKTSQVLGL", "length": 219, "header": "sp|Q58DM3-1|CD53_BOVIN Isoform 1 of Leukocyte surface antigen CD53 OS=Bos taurus OX=9913 GN=CD53 PE=2 SV=1 CANONICAL=Q58DM3-1" }, "locus": { "chromosome": "3", "start_pos": 32515858, "end_pos": 32494913, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008479.5", "url": "https://www.ensembl.org/id/ENSBTAT00000008479.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008479.3", "url": "https://www.ensembl.org/id/ENSBTAP00000008479.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 129, "start_aa": "Asn", "end_pos": 129, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn129", "evidence": [ { "id": "Q58DM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DM3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 148, "start_aa": "Asn", "end_pos": 148, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn148", "evidence": [ { "id": "Q58DM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DM3#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DM3", "url": "https://www.uniprot.org/uniprotkb/Q58DM3" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:505040", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505040", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7F9Z6-1", "protein_name": "Tetraspanin", "gene_name": "Cd53", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVKKRSYYPSMGMSSLKLLKYVLFFFNLLFWVCGCCILGFGIFFLVQNTYGVLFRNLPFLTLGNVLVIVGSIIMVVAFLGCMGSIKENKCLLMSFFVLLMIILLAEVTLAILLFVYEQKLNTYVAEGLNDSIQHYHSDNSTMAAWDFIQSHLQCCGVNSSSDWTSGPPSSCPPGADVQGCYNKAKLWFHSNFLYIGIITICVCVIQVLGMSFALTLNCQIDKTSQALGL", "length": 229 }, "evidence": [ { "id": "Q58DM3", "url": "https://omabrowser.org/oma/group/Q58DM3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1S628-1", "protein_name": "Tetraspanin", "gene_name": "CD53", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGISSLKLLKYVLFFFNLLFWFCGCCILGFGIYLLIHNDFGVLFHKLPSLTLGNVLIIVGSIIMVVAFLGCMGSIKENKCLLMSFFVLLLIILLAEVTLAILLFVYEPKLNVYVAEGLTDSIHRYHSDNSTKAAWDSIQTFLQCCGINGTSDWHGRPPTSCPTDSQVKGCFVKAKLWFHSNFLYIGIITICVCVIQVLGMSFALTLNCQIDKTSQVLGL", "length": 219 }, "evidence": [ { "id": "Q58DM3", "url": "https://omabrowser.org/oma/group/Q58DM3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P19397-1", "protein_name": "Leukocyte surface antigen CD53", "gene_name": "CD53", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGMSSLKLLKYVLFFFNLLFWICGCCILGFGIYLLIHNNFGVLFHNLPSLTLGNVFVIVGSIIMVVAFLGCMGSIKENKCLLMSFFILLLIILLAEVTLAILLFVYEQKLNEYVAKGLTDSIHRYHSDNSTKAAWDSIQSFLQCCGINGTSDWTSGPPASCPSDRKVEGCYAKARLWFHSNFLYIGIITICVCVIEVLGMSFALTLNCQIDKTSQTIGL", "length": 219 }, "evidence": [ { "id": "Q58DM3", "url": "https://omabrowser.org/oma/group/Q58DM3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P24485-1", "protein_name": "Leukocyte surface antigen CD53", "gene_name": "Cd53", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGMSSLKLLKYVLFFFNFLFWVCGCCILGFGIHLLVQNTYGILFRNLPFLTLGNVLVIVGSIIMVVAFLGCMGSIKENKCLLMSFFVLLLLILLAEVTLAILLFVYEKKINTLVAEGLNDSIQHYHSDNSTRMAWDFIQSQLQCCGVNGSSDWISGPPSSCPSGADVQGCYKKGQAWFHSNFLYIGIVTICVCVIQVLGMSFALTLNCQIDKTSQALGL", "length": 219 }, "evidence": [ { "id": "Q58DM3", "url": "https://omabrowser.org/oma/group/Q58DM3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q61451-1", "protein_name": "Leukocyte surface antigen CD53", "gene_name": "Cd53", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGMSSLKLLKYVLFIFNLLFWVCGCCILGFGIYFLVQNTYGVLFRNLPFLTLGNILVIVGSIIMVVAFLGCMGSIKENKCLLMSFFVLLLIILLAEVTIAILLFVYEQKLNTLVAEGLNDSIQHYHSDNSTMKAWDFIQTQLQCCGVNGSSDWTSGPPSSCPSGADVQGCYNKAKSWFHSNFLYIGIITICVCVIQVLGMSFALTLNCQIDKTSQALGL", "length": 219 }, "evidence": [ { "id": "Q58DM3", "url": "https://omabrowser.org/oma/group/Q58DM3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q58DM3", "url": "https://www.uniprot.org/uniprotkb/Q58DM3" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "Q58DM3", "url": "https://www.uniprot.org/uniprotkb/Q58DM3" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "Q58DM3", "url": "https://www.uniprot.org/uniprotkb/Q58DM3" } ], "pmid": "" }, { "name": "immunological synapse", "id": "GO:0001772", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001772", "evidence": [ { "database": "UniProtKB", "id": "Q58DM3", "url": "https://www.uniprot.org/uniprotkb/Q58DM3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q58DM3", "url": "https://www.uniprot.org/uniprotkb/Q58DM3" } ], "pmid": "" }, { "name": "protein-membrane adaptor activity", "id": "GO:0043495", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043495", "evidence": [ { "database": "UniProtKB", "id": "Q58DM3", "url": "https://www.uniprot.org/uniprotkb/Q58DM3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of myoblast fusion", "id": "GO:1901741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901741", "evidence": [ { "database": "UniProtKB", "id": "Q58DM3", "url": "https://www.uniprot.org/uniprotkb/Q58DM3" } ], "pmid": "" }, { "name": "receptor clustering", "id": "GO:0043113", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043113", "evidence": [ { "database": "UniProtKB", "id": "Q58DM3", "url": "https://www.uniprot.org/uniprotkb/Q58DM3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" }, { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DM3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 219, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DM3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DM3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 129, 148 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 129, "end_pos": 131 }, { "start_pos": 148, "end_pos": 150 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", 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}, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DQ3-1", "uniprot_ac": "Q58DQ3", "uniprot_id": "RL6_BOVIN", "mass": { "chemical_mass": 32690.0, "monoisotopic_mass": 32690.0 }, "refseq": { "ac": 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"https://www.uniprot.org/uniprotkb/Q58DQ3/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein eL6", "type": "synonym", "evidence": [ { "id": "NP_001026926", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026926" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q58DQ3", "url": "https://www.uniprot.org/uniprotkb/Q58DQ3#function" }, { "database": "UniProtKB", "id": "Q02878", "url": "https://www.uniprot.org/uniprotkb/Q02878#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DQ3", "url": "https://www.uniprot.org/uniprotkb/Q58DQ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL6", "url": "https://www.uniprot.org/uniprotkb/Q58DQ3", "locus": { "chromosome": "17", "start_pos": 61842303, "end_pos": 61838371, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031723", "url": "https://www.ensembl.org/id/ENSBTAG00000031723" } ] } } ], "crossref": [ { "id": "Q58DQ3", "url": "https://alphafold.ebi.ac.uk/entry/Q58DQ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031723", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031723", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13156", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13156", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511051", "url": "https://www.ncbi.nlm.nih.gov/gene/511051", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005568", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005568", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008991", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008991", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014722", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014722", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041997", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041997", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049633", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049633", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511051", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511051", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KWYNADD", "url": "https://omabrowser.org/oma/group/KWYNADD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DQ3", "url": "https://www.orthodb.org/?gene=Q58DQ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10715", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10715", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10715:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10715:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01159", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01159", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03868", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03868", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001026926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026926", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58DQ3", "url": "https://www.uniprot.org/uniprotkb/Q58DQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DQ3-1", "url": "https://www.uniprot.org/uniprotkb/Q58DQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGEKAEKPDTKEKKPEAKKADAGKKAKKVEKVKKVKKGKPHCSRNPVLVRGIGRYSRSAMYSRKALYKRKYSAAKSKVEKKKKVRVLATVTKPVGGDKNGGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSKHVRKLRASITPGTILIILTGRHRGKRVVFLKQLGSGLLLVTGPLSLNRVPLRRTHQKFVIATSTKIDISGVKIPEHLTDTYFKKKKLRKPRHQEGEIFDTEREKYEITEQRKVDQKAVDSQILRRIKAVPQLQGYLRSVFALTNGIYPHKVVF", "length": 287, "header": "sp|Q58DQ3-1|RL6_BOVIN Isoform 1 of Large ribosomal subunit protein eL6 OS=Bos taurus OX=9913 GN=RPL6 PE=2 SV=3 CANONICAL=Q58DQ3-1" }, "isoforms": [ { "isoform_ac": "Q58DQ3-1", "url": "https://www.uniprot.org/uniprotkb/Q58DQ3/entry#Q58DQ3-1", "sequence": { "sequence": "MAGEKAEKPDTKEKKPEAKKADAGKKAKKVEKVKKVKKGKPHCSRNPVLVRGIGRYSRSAMYSRKALYKRKYSAAKSKVEKKKKVRVLATVTKPVGGDKNGGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSKHVRKLRASITPGTILIILTGRHRGKRVVFLKQLGSGLLLVTGPLSLNRVPLRRTHQKFVIATSTKIDISGVKIPEHLTDTYFKKKKLRKPRHQEGEIFDTEREKYEITEQRKVDQKAVDSQILRRIKAVPQLQGYLRSVFALTNGIYPHKVVF", "length": 287, "header": "sp|Q58DQ3-1|RL6_BOVIN Isoform 1 of Large ribosomal subunit protein eL6 OS=Bos taurus OX=9913 GN=RPL6 PE=2 SV=3 CANONICAL=Q58DQ3-1" }, "locus": { "chromosome": "17", "start_pos": 61842261, "end_pos": 61838373, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033359.5", "url": "https://www.ensembl.org/id/ENSBTAT00000033359.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042411.2", "url": "https://www.ensembl.org/id/ENSBTAP00000042411.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 144, "start_aa": "Thr", "end_pos": 144, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr144", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 126, "end_pos": 126, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DQ3", "url": "https://www.uniprot.org/uniprotkb/Q58DQ3" } ], "site_lbl": "Ser126" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DQ3", "url": "https://www.uniprot.org/uniprotkb/Q58DQ3" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:511051", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511051", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "P05739-1", "protein_name": "Large ribosomal subunit protein eL6B", "gene_name": "RPL6B", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTAQQAPKWYPSEDVAAPKKTRKAVRPQKLRASLVPGTVLILLAGRFRGKRVVYLKHLEDNTLLVTGPFKVNGVPLRRVNARYVIATSTKVSVEGVNVEKFNVEYFAKEKLTKKEKKEANLFPEQQTKEIKTERVEDQKVVDKALLAEIKKTPLLKQYLSASFSLKNGDKPHLLKF", "length": 176 }, "evidence": [ { "id": "Q58DQ3", "url": "https://omabrowser.org/oma/group/Q58DQ3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P21533-1", "protein_name": "Large ribosomal subunit protein eL6", "gene_name": "Rpl6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGEKAEKPDKKEQKPAAKKAGGDATAPRALPAGAVKKSSSKAKKLRKSKPHCSRNPVLVRGIGRYSRSAMYSRKALYKRKYSAAKTKVEKKKKKEKVLATVTKTVGGDKNGGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSQHVRRLRSSITPGTVLIILTGRHRGKRVVFLKQLGSGLLLVTGPLALNRVPLRRTHQKFVIATSTKVDISKVKIPKHLTDAYFKKKPLRKPRHQEGEIFDTEKEKYEITEQRKADQKAVDSQILPKIKAVPQLQGYLRSQFSLTNGMYPHKLVF", "length": 298 }, "evidence": [ { "id": "Q58DQ3", "url": "https://omabrowser.org/oma/group/Q58DQ3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P47911-1", "protein_name": "Large ribosomal subunit protein eL6", "gene_name": "Rpl6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGEKAPDTKEKKPAAKKAGSDAAASRPRAAKVAKKVHPKGKKPKKAKPHCSRNPVLVRGIGRYSRSAMYSRKALYKRKYSAAKTKVEKKKKKEKVLATVTKTVGGDKNGGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSQHVRRLRSSITPGTVLIILTGRHRGKRVVFLKQLDSGLLLVTGPLVINRVPLRRTHQKFVIATSTKVDISDVKIPKHLTDAYFKKKQLRKPRHQEGEIFDTEKEKYEITEQRKADQKAVDLQILPKIKAVPQLQGYLRSQFSLTNGMYPHKLVF", "length": 296 }, "evidence": [ { "id": "Q58DQ3", "url": "https://omabrowser.org/oma/group/Q58DQ3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q02878-1", "protein_name": "Large ribosomal subunit protein eL6", "gene_name": "RPL6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGEKVEKPDTKEKKPEAKKVDAGGKVKKGNLKAKKPKKGKPHCSRNPVLVRGIGRYSRSAMYSRKAMYKRKYSAAKSKVEKKKKEKVLATVTKPVGGDKNGGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRHRGKRVVFLKQLASGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKKLRKPRHQEGEIFDTEKEKYEITEQRKIDQKAVDSQILPKIKAIPQLQGYLRSVFALTNGIYPHKLVF", "length": 288 }, "evidence": [ { "id": "Q58DQ3", "url": "https://omabrowser.org/oma/group/Q58DQ3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q2YGT9-1", "protein_name": "Large ribosomal subunit protein eL6", "gene_name": "RPL6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGEKAEKPGTKEKKPEAKKADAGGKVKKAKKVKKGKPHCSRNPVLVRGIGRYSRSAMYSRKALYKRKYSAAKSKVEKKKKVRVLATVTKPVGGDKNGGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSKHVRKLRASITPGTILIILTGRHRGKRVIFLKQLSSGLLLVTGPLSLNRVPLRRTHQKFVIATSTKIDISGVKIPEHLTDAYFKKKKLRKPRHQEGEIFDTEKEKYEISEQRKVDQKAVDSQILRRIKAVPQLQGYLRSVFALTNGIYPHKLVF", "length": 284 }, "evidence": [ { "id": "Q58DQ3", "url": "https://omabrowser.org/oma/group/Q58DQ3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q54D63-1", "protein_name": "Large ribosomal subunit protein eL6", "gene_name": "rpl6", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MALDNKFVAKGLRLYSARSVANRTKTFVAKKNKVVAPKKVVAPVTPVEKTFGKGKRVIAAKASKFAPSIPAEIRSTAAKKVQQKVALRKSITPGTVLIILAGRFAGKRVVALKQLDSGLILITGPFKVNGVPLRRIDQRYVIATSTKIDVSSVKVAATINDAYFAAEKKSTTKSEGAFFSDEKKAEKKKIADSRVADQKSVDSAILAVLKKEKFLTVYLKTKFYLKKGEFPHQLKF", "length": 236 }, "evidence": [ { "id": "Q58DQ3", "url": "https://omabrowser.org/oma/group/Q58DQ3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9C9C5-1", "protein_name": "Large ribosomal subunit protein eL6x", "gene_name": "RPL6C", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": 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"uniprot_ac": "Q58DT1", "uniprot_id": "RL7_BOVIN", "mass": { "chemical_mass": 29169.0, "monoisotopic_mass": 29169.0 }, "refseq": { "ac": "NP_001014928", "name": "large ribosomal subunit protein uL30", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014928" }, "gene_names": [ { "name": "RPL7", "type": "recommended", "evidence": [ { "id": "Q58DT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DT1" } ] }, { "name": "RPL7", "type": "synonym", "evidence": [ { "id": "NP_001014928", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014928" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein uL30", "type": "recommended", "evidence": [ { "id": "Q58DT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DT1/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L7", "type": "synonym", "evidence": [ { "id": "NP_001014928", "database": "RefSeq", "url": 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The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.", "evidence": [ { "database": "UniProtKB", "id": "Q58DT1", "url": "https://www.uniprot.org/uniprotkb/Q58DT1#function" }, { "database": "UniProtKB", "id": "P18124", "url": "https://www.uniprot.org/uniprotkb/P18124#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DT1", "url": "https://www.uniprot.org/uniprotkb/Q58DT1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL7", "url": "https://www.uniprot.org/uniprotkb/Q58DT1", "locus": {} } ], "crossref": [ { "id": "Q58DT1", "url": "https://alphafold.ebi.ac.uk/entry/Q58DT1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020139", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020139", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01657", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01657", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514966", "url": "https://www.ncbi.nlm.nih.gov/gene/514966", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005998", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005998", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012988", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012988", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035808", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035808", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039699", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039699", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514966", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514966", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IVEPWIA", "url": "https://omabrowser.org/oma/group/IVEPWIA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DT1", "url": "https://www.orthodb.org/?gene=Q58DT1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11524", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11524", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11524:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11524:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00327", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00327", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08079", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08079", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001014928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014928", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58DT1", "url": "https://www.uniprot.org/uniprotkb/Q58DT1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DT1-1", "url": "https://www.uniprot.org/uniprotkb/Q58DT1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGAEEKKKKVPAVPETLKKKRKNFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLGKYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN", "length": 248, "header": "sp|Q58DT1-1|RL7_BOVIN Isoform 1 of Large ribosomal subunit protein uL30 OS=Bos taurus OX=9913 GN=RPL7 PE=2 SV=1 CANONICAL=Q58DT1-1" }, "isoforms": [ { "isoform_ac": "Q58DT1-1", "url": "https://www.uniprot.org/uniprotkb/Q58DT1/entry#Q58DT1-1", "sequence": { "sequence": "MEGAEEKKKKVPAVPETLKKKRKNFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLGKYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN", "length": 248, "header": "sp|Q58DT1-1|RL7_BOVIN Isoform 1 of Large ribosomal subunit protein uL30 OS=Bos taurus OX=9913 GN=RPL7 PE=2 SV=1 CANONICAL=Q58DT1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 139, "end_pos": 139, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q58DT1", "url": "https://www.uniprot.org/uniprotkb/Q58DT1" } ], "site_lbl": "Tyr139" }, { "start_pos": 17, "end_pos": 17, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q58DT1", "url": "https://www.uniprot.org/uniprotkb/Q58DT1" } ], "site_lbl": "Thr17" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DT1", "url": "https://www.uniprot.org/uniprotkb/Q58DT1" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:514966", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514966", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4FHN2-1", "protein_name": "Large ribosomal subunit protein uL30", "gene_name": "RPL7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGSVKEKKKKVPAVPETLKKKRKNFAELRIKRLRKKFAQKMHMLLWKKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLGKYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN", "length": 253 }, "evidence": [ { "id": "Q58DT1", "url": "https://omabrowser.org/oma/group/Q58DT1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P11874-1", "protein_name": "Large ribosomal subunit protein uL30", "gene_name": "rpl7", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSQKVATKTAPVPESILKKRATSQKKAVDVAKLGRAQQLRNSRLNSVYFKRAEKYVSEYHKTEREAIRLNRIAKNSGTFYVPPAAKVAFVIRIRGINGVSPKPRKVLKLLRLLQLNNGVFVKLNKASINMLKLVEPYVAYGFPNLKSIKELIYKRGHLKIDGQRIPLTSNDMVEKQLGKFGIICVEDIIHEITTCGKHFKQVNNSLWPFKLNCPRGGFNMKKTPFLQGGDAGNREHLINNLIHRMN", "length": 246 }, "evidence": [ { "id": "Q58DT1", "url": "https://omabrowser.org/oma/group/Q58DT1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "P14148-1", "protein_name": "Large ribosomal subunit protein uL30", "gene_name": "Rpl7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEAVPEKKKKVATVPGTLKKKVPAGPKTLKKKVPAVPETLKKKRRNFAELKVKRLRKKFALKTLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNSLIARSLGKFGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN", "length": 270 }, "evidence": [ { "id": "Q58DT1", "url": "https://omabrowser.org/oma/group/Q58DT1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P18124-1", "protein_name": "Large ribosomal subunit protein uL30", "gene_name": "RPL7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGVEEKKKEVPAVPETLKKKRRNFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLGKYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN", "length": 248 }, "evidence": [ { "id": "Q58DT1", "url": "https://omabrowser.org/oma/group/Q58DT1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q12213-1", "protein_name": "Large ribosomal subunit protein uL30B", "gene_name": "RPL7B", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSTEKILTPESQLKKTKAQQKTAEQIAAERAARKAANKEKRAIILERNAAYQKEYETAERNIIQAKRDAKAAGSYYVEAQHKLVFVVRIKGINKIPPKPRKVLQLLRLTRINSGTFVKVTKATLELLKLIEPYVAYGYPSYSTIRQLVYKRGFGKINKQRVPLSDNAIIEANLGKYGILSIDDLIHEIITVGPHFKQANNFLWPFKLSNPSGGWGVPRKFKHFIQGGSFGNREEFINKLVKAMN", "length": 244 }, "evidence": [ { "id": "Q58DT1", "url": "https://omabrowser.org/oma/group/Q58DT1/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q5ZJ56-1", "protein_name": "Large ribosomal subunit protein uL30", "gene_name": "RPL7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MADKEAKKVPSVPESLLKRRQAYAAAKAKRLKRLLAQKKFRKAQRKIIYERAKAYHKEYRHMYRQEIRMARMARKAGNYYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVHDLIYKRGYGKINKKRIALTDNSLIRKRLGKLGIICMEDVIHEIYTVGKNFKVVNNFLWPFKLSSPRGGMKKKTIHFVEGGDAGNREDQINRLIRRMN", "length": 246 }, "evidence": [ { "id": "Q58DT1", "url": "https://omabrowser.org/oma/group/Q58DT1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9LHP1-1", "protein_name": "Large ribosomal subunit protein uL30w", "gene_name": "RPL7D", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MTEAESKTVVPESVLKKRKREEEWALAKKQELEAAKKQNAEKRKLIFNRAKQYSKEYQEKERELIQLKREAKLKGGFYVDPEAKLLFIIRIRGINAIDPKTKKILQLLRLRQIFNGVFLKVNKATINMLRRVEPYVTYGYPNLKSVKELIYKRGFGKLNHQRTALTDNSIVDQGLGKHGIICVEDLIHEIMTVGPHFKEANNFLWPFQLKAPLGGMKKKRNHYVEGGDAGNRENFINELVRRMN", "length": 244 }, "evidence": [ { "id": "Q58DT1", "url": "https://omabrowser.org/oma/group/Q58DT1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q58DT1", "url": "https://www.uniprot.org/uniprotkb/Q58DT1" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q58DT1", "url": "https://www.uniprot.org/uniprotkb/Q58DT1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "id": "GO:0000463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000463", "evidence": [ { "database": "UniProtKB", "id": "Q58DT1", "url": "https://www.uniprot.org/uniprotkb/Q58DT1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q58DT1", "url": "https://www.uniprot.org/uniprotkb/Q58DT1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DT1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 248, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DT1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DT1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 17, 139 ], "sequon_annotation_sites": [ { "start_pos": 119, "end_pos": 121 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { 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}, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DT3-1", "uniprot_ac": "Q58DT3", "uniprot_id": "ZDHC4_BOVIN", "mass": { "chemical_mass": 39710.0, "monoisotopic_mass": 39710.0 }, "refseq": { "ac": "NP_001030369", "name": "palmitoyltransferase ZDHHC4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030369" }, "gene_names": [ { "name": "ZDHHC4", "type": "recommended", "evidence": [ { "id": "Q58DT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DT3" } ] }, { "name": "ZDHHC4", "type": "synonym", "evidence": [ { "id": "NP_001030369", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030369" } ] } ], "protein_names": [ { "name": "Palmitoyltransferase ZDHHC4", "type": "recommended", "evidence": [ { "id": "Q58DT3", "database": "UniProtKB", "url": 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"type": "synonym", "evidence": [ { "id": "NP_001030369", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030369" } ] }, { "name": "zinc finger DHHC domain-containing protein 4", "type": "synonym", "evidence": [ { "id": "NP_001030369", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030369" } ] }, { "name": "zinc finger DHHC-type containing 4", "type": "synonym", "evidence": [ { "id": "NP_001030369", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030369" } ] }, { "name": "zinc finger, DHHC domain containing 4", "type": "synonym", "evidence": [ { "id": "NP_001030369", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030369" } ] } ], "function": [ { "annotation": "Palmitoyltransferase that could catalyze the addition of palmitate onto protein substrates including the D(2) dopamine receptor DRD2, GSK3B or MAVS. Mediates GSK3B palmitoylation to prevent its AKT1-mediated phosphorylation leading to activation of the STAT3 signaling pathway. Also catalyzes MAVS palmitoylation which promotes its stabilization and activation by inhibiting 'Lys-48'- but facilitating 'Lys-63'-linked ubiquitination.", "evidence": [ { "database": "UniProtKB", "id": "Q58DT3", "url": "https://www.uniprot.org/uniprotkb/Q58DT3#function" }, { "database": "UniProtKB", "id": "Q9NPG8", "url": "https://www.uniprot.org/uniprotkb/Q9NPG8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DT3", "url": "https://www.uniprot.org/uniprotkb/Q58DT3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZDHHC4", "url": "https://www.uniprot.org/uniprotkb/Q58DT3", "locus": { "chromosome": "25", "start_pos": 38417820, "end_pos": 38409729, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009547", "url": "https://www.ensembl.org/id/ENSBTAG00000009547" } ] } } ], "crossref": [ { "id": "Q58DT3", "url": "https://alphafold.ebi.ac.uk/entry/Q58DT3", "database": "AlphaFoldDB", "categories": [] }, { "id": "514338", "url": "https://www.ncbi.nlm.nih.gov/gene/514338", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001594", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001594", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514338", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514338", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58DT3", "url": "https://www.orthodb.org/?gene=Q58DT3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22883", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22883", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22883:SF466", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22883:SF466", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01529", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01529", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001030369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030369", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "36683", "url": "https://www.rhea-db.org/rhea/36683", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q58DT3", "url": "https://www.uniprot.org/uniprotkb/Q58DT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DT3-1", "url": "https://www.uniprot.org/uniprotkb/Q58DT3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDFLVLFLLYLALVLLGFVMICIGSKTHYLQGLISRGAQVFSYIIPECLQRAMLSVLHYLFHTRNYTFVVLHLILQGMVYTEYTWEIFGLCQQLEFSLYYLFLPYLLLIVNLLFFTLSCVTNPGTITKANELLFLQVYEFDGVMFPKNVRCPTCDLRKPARSKHCSVCNRCVHRFDHHCVWVNNCIGAWNTRYFLSYLFTLTASAATMAVVSTVFLVRLVVMSDVYLQTYVDDLGHLQVVDTVFLVQYLFLTFPRIVFLVGFVVVLSFLLGGYLCFCLYLAATNQTTNEWYKGDRAWCQHCPHVARPPAAEPQAYRNIHSHGLWSNLREIFLPATACYERKEK", "length": 343, "header": "sp|Q58DT3-1|ZDHC4_BOVIN Isoform 1 of Palmitoyltransferase ZDHHC4 OS=Bos taurus OX=9913 GN=ZDHHC4 PE=2 SV=1 CANONICAL=Q58DT3-1" }, "isoforms": [ { "isoform_ac": "Q58DT3-1", "url": "https://www.uniprot.org/uniprotkb/Q58DT3/entry#Q58DT3-1", "sequence": { "sequence": "MDFLVLFLLYLALVLLGFVMICIGSKTHYLQGLISRGAQVFSYIIPECLQRAMLSVLHYLFHTRNYTFVVLHLILQGMVYTEYTWEIFGLCQQLEFSLYYLFLPYLLLIVNLLFFTLSCVTNPGTITKANELLFLQVYEFDGVMFPKNVRCPTCDLRKPARSKHCSVCNRCVHRFDHHCVWVNNCIGAWNTRYFLSYLFTLTASAATMAVVSTVFLVRLVVMSDVYLQTYVDDLGHLQVVDTVFLVQYLFLTFPRIVFLVGFVVVLSFLLGGYLCFCLYLAATNQTTNEWYKGDRAWCQHCPHVARPPAAEPQAYRNIHSHGLWSNLREIFLPATACYERKEK", "length": 343, "header": "sp|Q58DT3-1|ZDHC4_BOVIN Isoform 1 of Palmitoyltransferase ZDHHC4 OS=Bos taurus OX=9913 GN=ZDHHC4 PE=2 SV=1 CANONICAL=Q58DT3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DT3", "url": "https://www.uniprot.org/uniprotkb/Q58DT3" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:514338", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514338", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q58DT3", "url": "https://www.uniprot.org/uniprotkb/Q58DT3" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q58DT3", "url": "https://www.uniprot.org/uniprotkb/Q58DT3" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q58DT3", "url": "https://www.uniprot.org/uniprotkb/Q58DT3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q58DT3", "url": "https://www.uniprot.org/uniprotkb/Q58DT3" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q58DT3", "url": "https://www.uniprot.org/uniprotkb/Q58DT3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein targeting to membrane", "id": "GO:0006612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006612", "evidence": [ { "database": "UniProtKB", "id": "Q58DT3", "url": "https://www.uniprot.org/uniprotkb/Q58DT3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-cysteine S-palmitoyltransferase activity", "id": "GO:0019706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019706", "evidence": [ { "database": "UniProtKB", "id": "Q58DT3", "url": "https://www.uniprot.org/uniprotkb/Q58DT3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 284, "end_pos": 286, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "36683", "name": "", "equation": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3X756-1", "E1BPA5-1", "F1MVC6-1", "E1B987-1", "E1BJK1-1", "F6R785-1", "A0AAA9TDW4-1", "A0AAA9TVJ9-1", "A0AAA9TM40-1", "E1B6X9-1", "E1BKA0-1", "E1BK60-1", "Q58CU4-1", "A2VDT6-1", "A0AAF6ZH94-1", "A0AAA9RZ07-1", "Q0VC89-1", "E1BLT8-1", "G3MXF3-1", "P15103-1", "Q2HJ95-1", "Q58DA8-1", "A0A3Q1M794-1", "A0A3Q1LVW6-1", "Q58DT3-1", "A0A3Q1M403-1", "A0ABI0NXA5-1" ], "evidence": [ { "id": "36683", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36683" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LVW6", "gene_name": "ZDHHC13", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0A3Q1LVW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0A3Q1LVW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6" } ] } ] }, { "uniprot_ac": "A0A3Q1M403", "gene_name": "", "activity": [ { "ec_number": "6.3.1.2", "activity": "L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] }, { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] }, { "ec_number": "6.3.1.2", "activity": "", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] } ] }, { "uniprot_ac": "A0A3Q1M794", "gene_name": "ZDHHC3", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0A3Q1M794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M794" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0A3Q1M794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M794" } ] } ] }, { "uniprot_ac": "A0AAA9RZ07", "gene_name": "ZDHHC8", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9RZ07", 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As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy.", "evidence": [ { "database": "UniProtKB", "id": "Q58DV0", "url": "https://www.uniprot.org/uniprotkb/Q58DV0#function" }, { "database": "UniProtKB", "id": "Q9BRX2", "url": "https://www.uniprot.org/uniprotkb/Q9BRX2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DV0", "url": "https://www.uniprot.org/uniprotkb/Q58DV0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PELO", "url": "https://www.uniprot.org/uniprotkb/Q58DV0", "locus": {} } ], "crossref": [ { "id": "Q58DV0", "url": "https://alphafold.ebi.ac.uk/entry/Q58DV0", "database": "AlphaFoldDB", "categories": [] }, { "id": "528728", "url": "https://www.ncbi.nlm.nih.gov/gene/528728", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004405", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004405", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005140", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005140", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005141", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005141", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005142", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005142", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038069", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038069", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042226", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042226", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058547", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058547", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528728", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528728", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DDLWHLK", "url": "https://omabrowser.org/oma/group/DDLWHLK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DV0", "url": "https://www.orthodb.org/?gene=Q58DV0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10853", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10853", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10853:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10853:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03464", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03464", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03465", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03465", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26356", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26356", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029738", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58DV0", "url": "https://www.uniprot.org/uniprotkb/Q58DV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DV0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DV0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLVRKDIEKDNAGQVTLVPEEPEDMWHTYNLVQVGDSLRASTIRKVQTESSTGSVGSNRVRTTLTLCVEAIDFDSQACQLRVKGTNIQENEYVKMGAYHTIELEPNRQFTLAKKQWDSVVLERIEQACDPAWSADVAAVVMQEGLAHICLVTPSMTLTRAKVEVNIPRKRKGNCSQHDRALERFYEQVVQAIQRHIHFDVVKCVLVASPGFVREQFCDYMFQQAVKTDNKVLLENRSKFLQVHASSGHKYSLKEALCDPTVASRLSDTKAAGEVKALDDFYKMLQHEPDRAFYGLKQVEKANEAMAIDTLLISDELFRHQDVATRSRYVRLVDSVKENAGTVRIFSSLHVSGEQLSQLTGIAAILRFPVPELSDQENDSSSEED", "length": 385, "header": "sp|Q58DV0-1|PELO_BOVIN Isoform 1 of Protein pelota homolog OS=Bos taurus OX=9913 GN=PELO PE=2 SV=2 CANONICAL=Q58DV0-1" }, "isoforms": [ { "isoform_ac": "Q58DV0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DV0/entry#Q58DV0-1", "sequence": { "sequence": "MKLVRKDIEKDNAGQVTLVPEEPEDMWHTYNLVQVGDSLRASTIRKVQTESSTGSVGSNRVRTTLTLCVEAIDFDSQACQLRVKGTNIQENEYVKMGAYHTIELEPNRQFTLAKKQWDSVVLERIEQACDPAWSADVAAVVMQEGLAHICLVTPSMTLTRAKVEVNIPRKRKGNCSQHDRALERFYEQVVQAIQRHIHFDVVKCVLVASPGFVREQFCDYMFQQAVKTDNKVLLENRSKFLQVHASSGHKYSLKEALCDPTVASRLSDTKAAGEVKALDDFYKMLQHEPDRAFYGLKQVEKANEAMAIDTLLISDELFRHQDVATRSRYVRLVDSVKENAGTVRIFSSLHVSGEQLSQLTGIAAILRFPVPELSDQENDSSSEED", "length": 385, "header": "sp|Q58DV0-1|PELO_BOVIN Isoform 1 of Protein pelota homolog OS=Bos taurus OX=9913 GN=PELO PE=2 SV=2 CANONICAL=Q58DV0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 374, "end_pos": 374, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DV0", "url": "https://www.uniprot.org/uniprotkb/Q58DV0" } ], "site_lbl": "Ser374" }, { "start_pos": 380, "end_pos": 380, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DV0", "url": "https://www.uniprot.org/uniprotkb/Q58DV0" } ], "site_lbl": "Ser380" }, { "start_pos": 381, "end_pos": 381, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DV0", "url": "https://www.uniprot.org/uniprotkb/Q58DV0" } ], "site_lbl": "Ser381" }, { "start_pos": 382, "end_pos": 382, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DV0", "url": "https://www.uniprot.org/uniprotkb/Q58DV0" } ], "site_lbl": "Ser382" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DV0", "url": "https://www.uniprot.org/uniprotkb/Q58DV0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:528728", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528728", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3HDZ6-1", "protein_name": "Protein pelota homolog", "gene_name": "Pelo", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKLVRKNIEKDNAGQVTLIPEEPEDMWHTYNLVQVGDSLRASTIRKVQTESSTGSVGSNRVRTTLTLCVEAIDFDSQACQLRVKGTNIQENEYVKMGAYHTIELEPNRQFTLAKKQWDSVVLERIEQACDPAWSADVAAVVMQEGLAHVCLVTPSMTLTRAKVEVNIPRKRKGNCSQHDKALERFYEQVVQAIQRHINFDVVKCVLVASPGFVREQFCDYMFQQAVKTDNKVLLENRSKFLQVHASSGHKYSLKEALCDPTVASRLSDTKAAGEVKALDDFYKMLQHEPDRAFYGLKQVERANEALAIDTLLISDELFRHQDVATRSRYVRLVDSVKDNAGTVRIFSSLHVSGEQLGQLTGVAAILRFPVPELSDQEDDSSSDED", "length": 385 }, "evidence": [ { "id": "Q58DV0", "url": "https://omabrowser.org/oma/group/Q58DV0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "H9L2N7-1", "protein_name": "Protein pelota homolog", "gene_name": "PELO", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKLVRKDLEKDNAGQVTLIPEEPEDMWHTYNLLQVGDSLRASTIRKVQTESSTGSVGSNRIRTTLTLCVEAIDFDSQACQLRVKGTNIQENEYVKMGAYHTIELEPNRQFTLAKKQWDSVVLERIEQACDPAWNADVAAVVMQEGLAHVCLVTPSMTLTRAKVEVNIPRKRKGNCSQHDRALERFYEQVVQAIQRHINFEVVKCVLVASPGFVREQFCDYMFQQAVKTDNKLLLENRSKFLQVHSSSGHKYALKEALCDPAVTSRLSDTKAAGEVKALDDFYKMLQHEPDRAFYGLKHVEKANEAMAIDTLLISDELFRHQDVATRARYVKLVDSVRENMGTVRIFSSLHVSGEQLGQLTGVAAILRFPVAELSDQEDESSSEED", "length": 385 }, "evidence": [ { "id": "Q58DV0", "url": "https://omabrowser.org/oma/group/Q58DV0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P48612-1", "protein_name": "Protein pelota", "gene_name": "pelo", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MKLLGKYVDKGMQGNVTLVPEESEDMWHAYNLIAKGDSVRSTTIRKVQNETATGSSTSSRVRTTLTIAVESIDFDTQACVLRLKGRNIEENQYVKMGAYHTLDLELNRKFELRKPEWDTIALERIEMACDPTQSADVAAVVMQEGLAHVCLITASMTLVRSKIEVSIPRKRKGSVQQHEKGLAKFYEQVMQSILRHVNFDVVKCVLIASPGFVRDQFYDYMFQQAVKMDYKLLLDNKSKFMLVHASSGFKHSLREILQDPAVLAKMSDTKAAGEVKALEQFYMMLQCEPAKAFYGKKHVLQAAESQAIETLLISDNLFRCQDVSLRKEYVNLVESIRDAGGEVKIFSSMHISGEQLAQLTGIAALLRFPMPELEDSDDDDDEDGAAGGVADSDSD", "length": 395 }, "evidence": [ { "id": "Q58DV0", "url": "https://omabrowser.org/oma/group/Q58DV0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q54VC8-1", "protein_name": "Protein pelota homolog", "gene_name": "pelo", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKLIKKYIEKDLSGYVKLQLEEEEDLWHCYNLISVGDLLTSSTVRKIQKETATGSVTSERQKLKITIQVTKIDHDNESSLLRVSGATCVENRFVKLGSFHTIDLEMNREFQLQKQEWDMISLELVKNATDIGQRADVAALIMNEGLANLCLITSAMTVVKSRIEVPVPRKGRSTSDNHQKGLENFFNTILQSMTRNINFDVVKCFIIASPAFVKDKFFQYMMDQSSKNDLYKVFRQNKSKFILTHSSSGHRYSLKEVLSDQAIVQQFSNTKAASEVKILNDFYDMLKKDPNRAFYGYEHVKKANERLAIETLLVTDELFRGKDVKTRKKYVDLVQSVKDNKGDVKLFSGLHVTGEQLSKLSGVAAILRYPLELEDEEEEYHPDESENGDDDDNNNNNNDDDDYSGYKNRSTRTSRDNDDSDDNDNKGNFEDEDYESFSSNR", "length": 441 }, "evidence": [ { "id": "Q58DV0", "url": "https://omabrowser.org/oma/group/Q58DV0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5XIP1-1", "protein_name": "Protein pelota homolog", "gene_name": "Pelo", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKLVRKDIEKDNAGQVTLVPEEPEDMWHTYNLVQVGDSLRASTIRKVQTESSTGSVGSNRVRTTLTLCVEAIDFDSQACQLRVKGTNIQENEYVKMGAYHTIELEPNRQFTLAKKQWDSVVLERIEQACDPAWSADVAAVVMQEGLAHVCLVTPSMTLTRAKVEVNIPRKRKGNCSQHDRALERFYEQVVQAIQRHINFEVVKCILVASPGFVREQFCDYMFQQAVKTDNKVLLENRSKFLQVHASSGHKYSLKEVLCDPTVASRLSDTKAAGEVKALDDFYKMLQHEPDRAFYGLKQVERANEALAIDTLLISDELFRHQDVATRSRYVRLVDSVKENAGTVRIFSSLHVSGEQLGQLTGVAAILRFPVPELSDQEDDSSSEED", "length": 385 }, "evidence": [ { "id": "Q58DV0", "url": "https://omabrowser.org/oma/group/Q58DV0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7ZWC4-1", "protein_name": "Protein pelota homolog", "gene_name": "pelo", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKLVHKDIEKDNAGQVTLIPDEAEDMWHTYNLLQVGDSLRASTIRKVQTESSTGSVGSSRVRTTLTLCVETIDFDSQACQLRVKGTNIQENQYVKMGAYHTIELELNRKFTLAKKVWDSVVLDRIEQACDPAQKADVAAVVMQEGLANLVLVTPAMTLLRAKVEVTIPRKRKGSCTQHDKALERFYEAVMQGILRHFNFDVVKCILVASPGFVKDQFISYLFKEAVRQDCKLLLENRSKFMVVHSSSGHKYSLKEVLCDPAVTARLSDTKAAGEVKALEDFYKMLQQEPDRAFYGLAHVERASEALAIDILLISDTLFRHQDVATRGRYVRLVDNVKENGGTVRIFSSLHVSGEQLNQLSGVAAILRFPIADVSEPEENSSSDED", "length": 385 }, "evidence": [ { "id": "Q58DV0", "url": "https://omabrowser.org/oma/group/Q58DV0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q80X73-1", "protein_name": "Protein pelota homolog", "gene_name": "Pelo", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKLVRKDIEKDNAGQVTLVPEEPEDMWHTFNLVQVGDSLRASTIRKVQTESSTGSVGSNRVRTTLTLCVEAIDFDSQACQLRVKGTNIQENEYVKMGAYHTIELEPNRQFTLAKKQWDSVVLERIEQACDPAWSADVAAVVMQEGLAHVCLVTPSMTLTRAKVEVNIPRKRKGNCSQHDRALERFYEQVVQAIQRHINFEVVKCVLVASPGFVREQFCDYMFQQAVKTDNKVLLENRSKFLQVHASSGHKYSLKEALCDPTVASRLSDTKAAGEVKALDDFYKMLQHEPDRAFYGLKQVERANEALAIDTLLISDELFRHQDVATRSRYVRLVDSVKENAGTVRIFSSLHVSGEQLGQLTGVAAILRFPVPELSDQEDDSSSEED", "length": 385 }, "evidence": [ { "id": "Q58DV0", "url": "https://omabrowser.org/oma/group/Q58DV0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BRX2-1", "protein_name": "Protein pelota homolog", "gene_name": "PELO", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKLVRKNIEKDNAGQVTLVPEEPEDMWHTYNLVQVGDSLRASTIRKVQTESSTGSVGSNRVRTTLTLCVEAIDFDSQACQLRVKGTNIQENEYVKMGAYHTIELEPNRQFTLAKKQWDSVVLERIEQACDPAWSADVAAVVMQEGLAHICLVTPSMTLTRAKVEVNIPRKRKGNCSQHDRALERFYEQVVQAIQRHIHFDVVKCILVASPGFVREQFCDYLFQQAVKTDNKLLLENRSKFLQVHASSGHKYSLKEALCDPTVASRLSDTKAAGEVKALDDFYKMLQHEPDRAFYGLKQVEKANEAMAIDTLLISDELFRHQDVATRSRYVRLVDSVKENAGTVRIFSSLHVSGEQLSQLTGVAAILRFPVPELSDQEGDSSSEED", "length": 385 }, "evidence": [ { "id": "Q58DV0", "url": "https://omabrowser.org/oma/group/Q58DV0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9ZT87-1", "protein_name": "Protein PELOTA 1", "gene_name": "PEL1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MKIVRRDFVRNGPGSVKMVAEDSDDLWYAYNLIAVGDSVMAVTFRKVQREIPGGGRDSERVKLKLEVQVEEVDYDKDGSVLRIRGKNILENEHVKIGAFHTLELELKRPFVLRKEMWDSMALDTLKQASDPAASADLAVVLMQEGLAQIFLVGRSVTSSRARIETSIPRKHGPAIAGYESALKKFFENVLQAFVKHVDFSVVRCAVVASPGFTKDQFHRHLLLEAERRQLRPIIENKSRIILVHTNSGYRHSLGEVLHAPNVMNMIKDTKAAKEVKALNDFHNMLSTEPDRACYGPKHVEVANERMAIQTLLITDELFRNSDVKTRKKYVNLVESVKDSGGDAFIFSAMHVSGEQLAQLTGIAALLRFPLPELEDIEM", "length": 378 }, "evidence": [ { "id": "Q58DV0", "url": "https://omabrowser.org/oma/group/Q58DV0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "rescue of stalled ribosome", "id": "GO:0072344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072344", "evidence": [ { "database": "UniProtKB", "id": "Q58DV0", "url": "https://www.uniprot.org/uniprotkb/Q58DV0" } ], "pmid": "" }, { "name": "ribosome disassembly", "id": "GO:0032790", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032790", "evidence": [ { "database": "UniProtKB", "id": "Q58DV0", "url": "https://www.uniprot.org/uniprotkb/Q58DV0" } ], "pmid": "" }, { "name": "nuclear-transcribed mRNA catabolic process, non-stop decay", "id": "GO:0070481", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070481", "evidence": [ { "database": "UniProtKB", "id": "Q58DV0", "url": "https://www.uniprot.org/uniprotkb/Q58DV0" } ], "pmid": "" }, { "name": "nonfunctional rRNA decay", "id": "GO:0070651", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070651", "evidence": [ { "database": "UniProtKB", "id": "Q58DV0", "url": "https://www.uniprot.org/uniprotkb/Q58DV0" } ], "pmid": "" }, { "name": "RNA surveillance", "id": "GO:0071025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071025", "evidence": [ { "database": "UniProtKB", "id": "Q58DV0", "url": "https://www.uniprot.org/uniprotkb/Q58DV0" } ], "pmid": "" }, { "name": "regulation of translation", "id": "GO:0006417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006417", "evidence": [ { "database": "UniProtKB", "id": "Q58DV0", "url": "https://www.uniprot.org/uniprotkb/Q58DV0" } ], "pmid": "" }, { "name": "nuclear-transcribed mRNA catabolic process, no-go decay", "id": "GO:0070966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070966", "evidence": [ { "database": "UniProtKB", "id": "Q58DV0", "url": "https://www.uniprot.org/uniprotkb/Q58DV0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58DV0", "url": "https://www.uniprot.org/uniprotkb/Q58DV0" } ], "pmid": "" }, { "name": "Dom34-Hbs1 complex", "id": "GO:1990533", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990533", "evidence": [ { "database": "UniProtKB", "id": "Q58DV0", "url": "https://www.uniprot.org/uniprotkb/Q58DV0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q58DV0", "url": "https://www.uniprot.org/uniprotkb/Q58DV0" } ], "pmid": "" }, { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "Q58DV0", "url": "https://www.uniprot.org/uniprotkb/Q58DV0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 174, "end_pos": 176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 236, "end_pos": 238, "annotation": "n_glycosylation_sequon" }, { "start_pos": 378, "end_pos": 380, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q58DV0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 385, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q58DV0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q58DV0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 374, 380, 381, 382 ], "sequon_annotation_sites": [ { "start_pos": 174, "end_pos": 176 }, { "start_pos": 236, "end_pos": 238 }, { "start_pos": 378, "end_pos": 380 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001014894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014894", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58DW0", "url": "https://www.uniprot.org/uniprotkb/Q58DW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DW0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DW0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDIKKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMLNTDLSRILKSPEIQRALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKIRMDKAAAALEAKSDQKGVQGKKPVVGNKEKKAVGDKKLKKPVVGKKAAGTKKPAAEKKPTEKKPTSEEKKAAA", "length": 422, "header": "sp|Q58DW0-1|RL4_BOVIN Isoform 1 of Large ribosomal subunit protein uL4 OS=Bos taurus OX=9913 GN=RPL4 PE=2 SV=3 CANONICAL=Q58DW0-1" }, "isoforms": [ { "isoform_ac": "Q58DW0-1", "url": "https://www.uniprot.org/uniprotkb/Q58DW0/entry#Q58DW0-1", "sequence": { "sequence": "MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDIKKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMLNTDLSRILKSPEIQRALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKIRMDKAAAALEAKSDQKGVQGKKPVVGNKEKKAVGDKKLKKPVVGKKAAGTKKPAAEKKPTEKKPTSEEKKAAA", "length": 422, "header": "sp|Q58DW0-1|RL4_BOVIN Isoform 1 of Large ribosomal subunit protein uL4 OS=Bos taurus OX=9913 GN=RPL4 PE=2 SV=3 CANONICAL=Q58DW0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 266, "end_pos": 266, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q58DW0", "url": "https://www.uniprot.org/uniprotkb/Q58DW0" } ], "site_lbl": "Thr266" }, { "start_pos": 290, "end_pos": 290, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DW0", "url": "https://www.uniprot.org/uniprotkb/Q58DW0" } ], "site_lbl": "Ser290" }, { "start_pos": 295, "end_pos": 295, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DW0", "url": "https://www.uniprot.org/uniprotkb/Q58DW0" } ], "site_lbl": "Ser295" }, { "start_pos": 362, "end_pos": 362, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DW0", "url": "https://www.uniprot.org/uniprotkb/Q58DW0" } ], "site_lbl": "Ser362" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DW0", "url": "https://www.uniprot.org/uniprotkb/Q58DW0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:510547", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510547", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "P09180-1", "protein_name": "Large ribosomal subunit protein uL4", "gene_name": "RpL4", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q58DW5-1", "uniprot_ac": "Q58DW5", "uniprot_id": "RL5_BOVIN", "mass": { "chemical_mass": 34345.0, "monoisotopic_mass": 34345.0 }, "refseq": { "ac": "NP_001030383", "name": "large ribosomal subunit protein uL18", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030383" }, "gene_names": [ { "name": "RPL5", "type": "recommended", "evidence": [ { "id": "Q58DW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW5" } ] }, { "name": "RPL5", "type": "synonym", "evidence": [ { "id": "NP_001030383", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030383" } ] } ], "protein_names": [ { "name": "Large ribosomal subunit protein uL18", "type": "recommended", "evidence": [ { "id": "Q58DW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW5/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L5", "type": "synonym", "evidence": [ { "id": "NP_001030383", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030383" }, { "id": "Q58DW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW5/entry#names_and_taxonomy" } ] }, { "name": "large ribosomal subunit protein uL18", "type": "synonym", "evidence": [ { "id": "NP_001030383", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030383" } ] } ], "function": [ { "annotation": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53.", "evidence": [ { "database": "UniProtKB", "id": "Q58DW5", "url": "https://www.uniprot.org/uniprotkb/Q58DW5#function" }, { "database": "UniProtKB", "id": "P46777", "url": "https://www.uniprot.org/uniprotkb/P46777#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q58DW5", "url": "https://www.uniprot.org/uniprotkb/Q58DW5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL5", "url": "https://www.uniprot.org/uniprotkb/Q58DW5", "locus": {} } ], "crossref": [ { "id": "Q58DW5", "url": "https://alphafold.ebi.ac.uk/entry/Q58DW5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002026", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002026", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00432", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00432", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515238", "url": "https://www.ncbi.nlm.nih.gov/gene/515238", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005485", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005485", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057268", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057268", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515238", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515238", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CQIASAH", "url": "https://omabrowser.org/oma/group/CQIASAH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q58DW5", "url": "https://www.orthodb.org/?gene=Q58DW5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23410", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23410", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23410:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23410:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14204", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14204", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17144", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17144", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001030383", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030383", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q58DW5", "url": "https://www.uniprot.org/uniprotkb/Q58DW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q58DW5-1", "url": "https://www.uniprot.org/uniprotkb/Q58DW5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFSAEVHRKHIMGQNVADYMRYLIEEDEDAYKKQFSQYIKNNVTPDMMEEMYKKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES", "length": 297, "header": "sp|Q58DW5-1|RL5_BOVIN Isoform 1 of Large ribosomal subunit protein uL18 OS=Bos taurus OX=9913 GN=RPL5 PE=2 SV=3 CANONICAL=Q58DW5-1" }, "isoforms": [ { "isoform_ac": "Q58DW5-1", "url": "https://www.uniprot.org/uniprotkb/Q58DW5/entry#Q58DW5-1", "sequence": { "sequence": "MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFSAEVHRKHIMGQNVADYMRYLIEEDEDAYKKQFSQYIKNNVTPDMMEEMYKKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES", "length": 297, "header": "sp|Q58DW5-1|RL5_BOVIN Isoform 1 of Large ribosomal subunit protein uL18 OS=Bos taurus OX=9913 GN=RPL5 PE=2 SV=3 CANONICAL=Q58DW5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 185, "end_pos": 185, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DW5", "url": "https://www.uniprot.org/uniprotkb/Q58DW5" } ], "site_lbl": "Ser185" }, { "start_pos": 232, "end_pos": 232, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q58DW5", "url": "https://www.uniprot.org/uniprotkb/Q58DW5" } ], "site_lbl": "Thr232" }, { "start_pos": 272, "end_pos": 272, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q58DW5", "url": "https://www.uniprot.org/uniprotkb/Q58DW5" } ], "site_lbl": "Ser272" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q58DW5", "url": "https://www.uniprot.org/uniprotkb/Q58DW5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:515238", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515238", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1U3N9-1", "protein_name": "Large ribosomal subunit protein uL18", "gene_name": "RPL5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSKGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHILGQNVADYMRYLIEEDEDAYKKQFSQYIKNNVTPDMMEEMYKKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES", "length": 299 }, "evidence": [ { "id": "Q58DW5", "url": "https://omabrowser.org/oma/group/Q58DW5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P22451-1", "protein_name": "Large ribosomal subunit protein uL18", "gene_name": "RPL5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNKFGLDKIYEGQVEVTGDEYNVESVDGKPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNNITPDGMEEMYKKAHAAIRDNPVHEKKPKREVKKKRVNSTKMSLAQKKDRVAQKKASFLRAQERAADS", "length": 297 }, "evidence": [ { "id": "Q58DW5", "url": "https://omabrowser.org/oma/group/Q58DW5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P46777-1", "protein_name": "Large ribosomal subunit protein uL18", "gene_name": "RPL5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMYKKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES", "length": 297 }, "evidence": [ { "id": "Q58DW5", "url": "https://omabrowser.org/oma/group/Q58DW5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P47962-1", "protein_name": "Large ribosomal subunit protein uL18", "gene_name": "Rpl5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGFVKVVKNKAYFKRYQVRFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVNGGEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMYKKAHAAIRENPVYEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES", "length": 297 }, "evidence": [ { "id": "Q58DW5", "url": "https://omabrowser.org/oma/group/Q58DW5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P49227-1", "protein_name": "Large ribosomal subunit protein uL18y", "gene_name": "RPL5B", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVFVKSSKSNAYFKRYQVKFRRRRDGKTDYRARIRLINQDKNKYNTPKYRFVVRFTNKDIVAQIVSASIAGDIVKASAYAHELPQYGLTVGLTNYAAAYCTGLLLARRVLKMLEMDDEYEGNVEATGEDFSVEPTDSRRPFRALLDVGLIRTTTGNRVFGALKGALDGGLDIPHSDKRFAGFHKENKQLDAEIHRNYIYGGHVSNYMKLLGEDEPEKLQTHFSAYIKKGVEAESIEEMYKKVHAAIRAEPNHKKTEKSAPKEHKRYNLKKLTYEERKNKLIERVKALNGAGGDDDDEDDEE", "length": 301 }, "evidence": [ { "id": "Q58DW5", "url": "https://omabrowser.org/oma/group/Q58DW5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q54XX3-1", "protein_name": "Large ribosomal subunit protein uL18", "gene_name": "rpl5", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGFVKVVKTKAYYSRYQVQFRRRREGKTDYQQRHRLITQDKNKYNSPKYRLVARITNTDVIAQVVYSKIVGDFVLCAAYAHELPRFGVKVGLTNYASCYATGLLLARRLLAKLKLADLYKGAEKVDGKVFLVKPVDDKPRPFKANLDVGLARTSTGAKVFAVLKGAVDGGIYVPHGETRFAGYNAESKKLNAETLRGYIFGKHVASYMTLLQTEDEDAYKKIFSQYIKNGVAPKDIETIYANAHKAIRANPAPAAKSTKSYKDIKSKNLSKRTLKQKKARVASIKASYKARL", "length": 292 }, "evidence": [ { "id": "Q58DW5", "url": "https://omabrowser.org/oma/group/Q58DW5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q58DW5", "url": "https://www.uniprot.org/uniprotkb/Q58DW5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q58DW5", "url": "https://www.uniprot.org/uniprotkb/Q58DW5" } ], "pmid": "" }, { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q58DW5", "url": "https://www.uniprot.org/uniprotkb/Q58DW5" } ], "pmid": "" } ] }, { "name": 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PE=2 SV=1 CANONICAL=Q5BIR3-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 106, "start_aa": "Asn", "end_pos": 106, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn106", "evidence": [ { "id": "Q5BIR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIR3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 303, "start_aa": "Asn", "end_pos": 303, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn303", "evidence": [ { "id": "Q5BIR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIR3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 39, "start_aa": "Asn", "end_pos": 39, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn39", "evidence": [ { "id": "Q5BIR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIR3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 50, "start_aa": "Asn", "end_pos": 50, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn50", "evidence": [ { "id": "Q5BIR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIR3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 55, "start_aa": "Asn", "end_pos": 55, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn55", "evidence": [ { "id": "Q5BIR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIR3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 66, "start_aa": "Asn", "end_pos": 66, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn66", "evidence": [ { "id": "Q5BIR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIR3#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 675, "start_aa": "Thr", "end_pos": 675, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr675", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 77, "start_aa": "Asn", "end_pos": 77, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn77", "evidence": [ { 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[ { "id": "Q5E938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E938" } ] }, { "name": "EIF1", "type": "synonym", "evidence": [ { "id": "NP_001014884", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014884" } ] }, { "name": "SUI1", "type": "synonym", "evidence": [ { "id": "NP_001014884", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014884" }, { "id": "Q5E938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E938" } ] } ], "protein_names": [ { "name": "Eukaryotic translation initiation factor 1", "type": "recommended", "evidence": [ { "id": "Q5E938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E938/entry#names_and_taxonomy" } ] }, { "name": "Protein translation factor SUI1 homolog", "type": "synonym", "evidence": [ { "id": "Q5E938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E938/entry#names_and_taxonomy" } ] }, { "name": "eIF1", "type": "synonym", "evidence": [ { "id": "Q5E938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E938/entry#names_and_taxonomy" } ] }, { "name": "eukaryotic translation initiation factor 1", "type": "synonym", "evidence": [ { "id": "NP_001014884", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014884" } ] }, { "name": "protein translation factor SUI1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001014884", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014884" } ] } ], "function": [ { "annotation": "Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. Together with eIF1A (EIF1AX), EIF1 facilitates scanning and is essential for start codon recognition on the basis of AUG nucleotide context and location relative to the 5'-cap. Participates to initiation codon selection by influencing the conformation of the 40S ribosomal subunit and the positions of bound mRNA and initiator tRNA; this is possible after its binding to the interface surface of the platform of the 40S ribosomal subunit close to the P-site. Together with eIF1A (EIF1AX), also regulates the opening and closing of the mRNA binding channel, which ensures mRNA recruitment, scanning and the fidelity of initiation codon selection. Continuously monitors and protects against premature and partial base-pairing of codons in the 5'-UTR with the anticodon of initiator tRNA. Together with eIF1A (EIF1AX), acts for ribosomal scanning, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. Interacts with EIF4G1, which in a mutual exclusive interaction associates either with EIF1 or with EIF4E on a common binding site. EIF4G1-EIF1 complex promotes ribosome scanning (on both short and long 5'UTR), leaky scanning (on short 5'UTR) which is the bypass of the initial start codon, and discrimination against cap-proximal AUG. Is probably maintained within the 43S PIC in open conformation thanks to EIF1A-EIF5 interaction. Once the correct start codon is reached, EIF1 is physically excluded from the decoding site, shifting the PIC into the closed conformation and arresting it at the start codon.", "evidence": [ { "database": "UniProtKB", "id": "Q5E938", "url": "https://www.uniprot.org/uniprotkb/Q5E938#function" }, { "database": "UniProtKB", "id": "P41567", "url": "https://www.uniprot.org/uniprotkb/P41567#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E938", "url": "https://www.uniprot.org/uniprotkb/Q5E938" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF1", "url": "https://www.uniprot.org/uniprotkb/Q5E938", "locus": { "chromosome": "19", "start_pos": 41909777, "end_pos": 41907220, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": 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"https://www.ebi.ac.uk/interpro/entry/IPR036877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509764", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509764", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VENHIHI", "url": "https://omabrowser.org/oma/group/VENHIHI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E938", "url": "https://www.orthodb.org/?gene=Q5E938", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10388", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10388", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01253", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01253", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014884", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E938", "url": "https://www.uniprot.org/uniprotkb/Q5E938", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E938-1", "url": "https://www.uniprot.org/uniprotkb/Q5E938-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAIQNLHSFDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTVIEHPEYGEVIQLQGDQRKNICQFLVEIGLAKDDQLKVHGF", "length": 113, "header": "sp|Q5E938-1|EIF1_BOVIN Isoform 1 of Eukaryotic translation initiation factor 1 OS=Bos taurus OX=9913 GN=EIF1 PE=3 SV=1 CANONICAL=Q5E938-1" }, "isoforms": [ { "isoform_ac": "Q5E938-1", "url": "https://www.uniprot.org/uniprotkb/Q5E938/entry#Q5E938-1", "sequence": { "sequence": "MSAIQNLHSFDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTVIEHPEYGEVIQLQGDQRKNICQFLVEIGLAKDDQLKVHGF", "length": 113, "header": "sp|Q5E938-1|EIF1_BOVIN Isoform 1 of Eukaryotic translation initiation factor 1 OS=Bos taurus OX=9913 GN=EIF1 PE=3 SV=1 CANONICAL=Q5E938-1" }, "locus": { 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E959-1", "uniprot_ac": "Q5E959", "uniprot_id": "STRAP_BOVIN", "mass": { "chemical_mass": 38485.0, "monoisotopic_mass": 38485.0 }, "refseq": { "ac": "NP_001015567", "name": "serine-threonine kinase receptor-associated protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015567" }, "gene_names": [ { "name": "STRAP", "type": "recommended", "evidence": [ { "id": "Q5E959", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E959" } ] }, { "name": "STRAP", "type": "synonym", "evidence": [ { "id": "NP_001015567", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015567" } ] } ], "protein_names": [ { "name": "Serine-threonine kinase receptor-associated protein", "type": "recommended", "evidence": [ { "id": "Q5E959", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E959/entry#names_and_taxonomy" } ] }, { "name": "serine-threonine kinase receptor-associated protein", "type": "synonym", "evidence": [ { "id": "NP_001015567", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015567" } ] } ], "function": [ { "annotation": "The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E959", "url": "https://www.uniprot.org/uniprotkb/Q5E959#function" }, { "database": "UniProtKB", "id": "Q9Y3F4", "url": "https://www.uniprot.org/uniprotkb/Q9Y3F4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E959", "url": "https://www.uniprot.org/uniprotkb/Q5E959" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STRAP", "url": "https://www.uniprot.org/uniprotkb/Q5E959", "locus": { "chromosome": "5", "start_pos": 94018317, "end_pos": 94039904, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014175", "url": "https://www.ensembl.org/id/ENSBTAG00000014175" } ] } } ], "crossref": [ { "id": "Q5E959", "url": "https://alphafold.ebi.ac.uk/entry/Q5E959", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014175", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014175", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510201", "url": "https://www.ncbi.nlm.nih.gov/gene/510201", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056551", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056551", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510201", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510201", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DGFYGLW", "url": "https://omabrowser.org/oma/group/DGFYGLW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E959", "url": "https://www.orthodb.org/?gene=Q5E959", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19877", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19877", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19877:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19877:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23098", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23098", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2173788", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2173788", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015567", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E959", "url": "https://www.uniprot.org/uniprotkb/Q5E959", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E959-1", "url": "https://www.uniprot.org/uniprotkb/Q5E959-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFVVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGLWKCVLPEEDSGELAKPKINFPETAEEELEEIASENSDSIYSSTPEVKA", "length": 350, "header": "sp|Q5E959-1|STRAP_BOVIN Isoform 1 of Serine-threonine kinase receptor-associated protein OS=Bos taurus OX=9913 GN=STRAP PE=2 SV=1 CANONICAL=Q5E959-1" }, "isoforms": [ { "isoform_ac": "Q5E959-1", "url": "https://www.uniprot.org/uniprotkb/Q5E959/entry#Q5E959-1", "sequence": { "sequence": "MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFVVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGLWKCVLPEEDSGELAKPKINFPETAEEELEEIASENSDSIYSSTPEVKA", "length": 350, "header": "sp|Q5E959-1|STRAP_BOVIN Isoform 1 of Serine-threonine kinase receptor-associated protein OS=Bos taurus OX=9913 GN=STRAP PE=2 SV=1 CANONICAL=Q5E959-1" }, "locus": { "chromosome": "5", "start_pos": 94039624, "end_pos": 94019986, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018840.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018840.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018840.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018840.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 312, "end_pos": 312, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E959", "url": "https://www.uniprot.org/uniprotkb/Q5E959" } ], "site_lbl": "Ser312" }, { "start_pos": 335, "end_pos": 335, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E959", "url": "https://www.uniprot.org/uniprotkb/Q5E959" } ], "site_lbl": "Ser335" }, { "start_pos": 338, "end_pos": 338, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E959", "url": "https://www.uniprot.org/uniprotkb/Q5E959" } ], "site_lbl": "Ser338" }, { "start_pos": 342, "end_pos": 342, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q5E959", "url": "https://www.uniprot.org/uniprotkb/Q5E959" } ], "site_lbl": "Tyr342" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E959", "url": "https://www.uniprot.org/uniprotkb/Q5E959" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:510201", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510201", "resource": "KEGG Pathway" }, { "id": "R-BTA-2173788", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2173788", "resource": "Reactome", "description": "Downregulation of TGF-beta receptor signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VAU7-1", "protein_name": "Serine-threonine kinase receptor-associated protein", "gene_name": "STRAP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHSSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAISLDPIKSFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGLWKCVLPEEDSGELAKPKISFPETAEEELEEITSENSDSIYSSTPEVKA", "length": 350 }, "evidence": [ { "id": "Q5E959", "url": "https://omabrowser.org/oma/group/Q5E959/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q54LT8-1", "protein_name": "Serine-threonine kinase receptor-associated protein", "gene_name": "strap", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MRQPLICSGHSRPVSDLSFSNENSDGSFIVSACLDGSPMLRNGENGDWIGTFEGHKGAVWSSRFNSTASQALTASADYTVKLWDTLNGSEILSIEHQSIVKTADFSNNNSRVVTGGSEKILRIFDLERPNDPLLQISGHTNTIKTATWSVHNDDIVLSGGLDEVIRIWDLRSGTQVSLCAKSSITSMEFSKDRRFLVTTAGNEVTFWDAQSFYPLKVYSLPFDVNCASLHPDNSKFIAGGSDFWVHVYDFSTGNEIEVNKGHHGPVNCCRFSPDGASFASGSLDGTIRLWKGM", "length": 293 }, "evidence": [ { "id": "Q5E959", "url": "https://omabrowser.org/oma/group/Q5E959/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5XIG8-1", "protein_name": "Serine-threonine kinase receptor-associated protein", "gene_name": "Strap", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLEPIKSFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPETAEEELEEIASENSDSIYSSTPEVKA", "length": 350 }, "evidence": [ { "id": "Q5E959", "url": "https://omabrowser.org/oma/group/Q5E959/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5ZL33-1", "protein_name": "Serine-threonine kinase receptor-associated protein", "gene_name": "STRAP", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAMRQTPLTCSGHTRPVVDLAFSGVTPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELITLAHKHIVKSVDFTQDSNYLLTGGQDKLLRIYDLSKPEAEPDVVSGHTSGIKKALWSSDDKQILSADDKTVRLWDRSTMTEVKALNVAMSVSSMEYVPEGQILVITYGKTIAFHSAETLEQIKSFEAPATINSASLHPEKECLVAGGEDFKLYKYDYNTGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTTVGKTYGLWKCVVPEEENAEAAKARTTLPGTAEEEIEEVASENSDSVYSSTPEVKA", "length": 350 }, "evidence": [ { "id": "Q5E959", "url": "https://omabrowser.org/oma/group/Q5E959/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9W1N4-1", "protein_name": "Serine-threonine kinase receptor-associated protein", "gene_name": "wmd", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAANNLRQIPLTCSGHTRPVVHLDFSDICDAGYFLISACKDGSPMLRHGDTGDWVGTFEGHKGAVWNATLNRNATLAASGAADFTGKVWNAVTGAEIHSFQHKHIVKSVAFDRDSENIVTGSNEKLVRVFNLEQPEAQPEEYAGHTGAIKRALFCRGDKCIISAAEDKTVRLWDRMTGIEVQRLQFNSNPNSLEISSDNHILTISHGSSISFWEIDTLKKLKEVKVPTNVASASLHPDKHVFVCGGEDFKMYKFDYITGNEIESFKGHFGPVHSVKFSPDGELYASGSEDGTLRLWQTTVGKTYGLWKCTEPADLGNSISSPREVQAN", "length": 328 }, "evidence": [ { "id": "Q5E959", "url": "https://omabrowser.org/oma/group/Q5E959/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y3F4-1", "protein_name": "Serine-threonine kinase receptor-associated protein", "gene_name": "STRAP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA", "length": 350 }, "evidence": [ { "id": "Q5E959", "url": "https://omabrowser.org/oma/group/Q5E959/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z1Z2-1", "protein_name": "Serine-threonine kinase receptor-associated protein", "gene_name": "Strap", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSDDKQILSADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLEPIKSFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPETAEEELEEIASENSDSIYSSTPEVKA", "length": 350 }, "evidence": [ { "id": "Q5E959", "url": "https://omabrowser.org/oma/group/Q5E959/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q5E959", "url": "https://www.uniprot.org/uniprotkb/Q5E959" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "Q5E959", "url": "https://www.uniprot.org/uniprotkb/Q5E959" } ], "pmid": "" }, { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "Q5E959", "url": "https://www.uniprot.org/uniprotkb/Q5E959" } ], "pmid": "" }, { "name": "U2 snRNP binding", "id": "GO:1990447", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990447", "evidence": [ { "database": "UniProtKB", "id": "Q5E959", "url": "https://www.uniprot.org/uniprotkb/Q5E959" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E959", "url": "https://www.uniprot.org/uniprotkb/Q5E959" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5E959", "url": "https://www.uniprot.org/uniprotkb/Q5E959" } ], "pmid": "" }, { "name": "SMN complex", "id": "GO:0032797", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032797", "evidence": [ { "database": "UniProtKB", "id": "Q5E959", "url": "https://www.uniprot.org/uniprotkb/Q5E959" } ], "pmid": "" }, { "name": "SMN-Sm protein complex", "id": "GO:0034719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034719", "evidence": [ { "database": "UniProtKB", "id": "Q5E959", "url": "https://www.uniprot.org/uniprotkb/Q5E959" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q5E959", "url": "https://www.uniprot.org/uniprotkb/Q5E959" } ], "pmid": "" }, { "name": "maintenance of gastrointestinal epithelium", "id": "GO:0030277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030277", "evidence": [ { "database": "UniProtKB", 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"https://www.uniprot.org/uniprotkb/Q5E964/entry#A0ABI0NWG7-1", "sequence": { "sequence": "MKDVPGFLQQSQSSGPGQAAVWHRLEELYTKKLWHQLTLQVLDFVQDPCFAQGDGLIKLYENFISEFEHRVNPLSLVEIILHVVRQMTDPNVALSFLEKTREKVKSSDEAVILCKTAIGALKLNIGDLQVTKETIEDVEEMLSNLPGVTSVHSRFYDLSSKYYQTIGNHASYYKDALRFLGCVDIKDLPVSEQQERAFTLGLAGLLGDGVFNFGELLMHPVLESLRDTDRQWLIDTLYAFNSGNVERFQTLKTAWGQQPDLAANEAQLLRKIQLLCLMEMTFTRPANHRQLTFEEIARSAKITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQAMSYSSPPTPNAA", "length": 358, "header": "tr|A0ABI0NWG7-1|A0ABI0NWG7_BOVIN Computationally mapped isoform of 26S proteasome non-ATPase regulatory subunit 13 OS=Bos taurus OX=9913 GN=PSMD13 PE=3 SV=1 CANONICAL=Q5E964-1" }, "locus": { "chromosome": "11", "start_pos": 82925300, "end_pos": 82902994, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000139437.1", "url": "https://www.ensembl.org/id/ENSBTAT00000139437.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105344.1", "url": 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"id": "ENSBTAP00000104424.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104424.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E964", "url": "https://www.uniprot.org/uniprotkb/Q5E964" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:513525", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513525", "resource": "KEGG Pathway" }, { "id": "R-BTA-1169091", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1169091", "resource": "Reactome", "description": 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May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity. Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (By similarity). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis. However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E969", "url": "https://www.uniprot.org/uniprotkb/Q5E969#function" }, { "database": "UniProtKB", "id": "Q9NR00", "url": "https://www.uniprot.org/uniprotkb/Q9NR00#function" }, { "database": "UniProtKB", "id": "Q9D915", "url": "https://www.uniprot.org/uniprotkb/Q9D915#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E969", "url": "https://www.uniprot.org/uniprotkb/Q5E969" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TCIM", "url": "https://www.uniprot.org/uniprotkb/Q5E969", "locus": { "chromosome": "27", "start_pos": 35235637, "end_pos": 35231590, "strand": "-", "evidence": [ { 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[ "Protein" ] }, { "id": "Q5E969-1", "url": "https://www.uniprot.org/uniprotkb/Q5E969-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKAKPSHPAFSMSTSLRVSPSIHGYHFDTASRKKAVGNIFENIDQEALQRLFRNSGDKKAEERAKIIFAIDQDLEEKTRALMALKKRTKDKLFQFLKLRKYSIKVH", "length": 106, "header": "sp|Q5E969-1|TCIM_BOVIN Isoform 1 of Transcriptional and immune response regulator OS=Bos taurus OX=9913 GN=TCIM PE=3 SV=1 CANONICAL=Q5E969-1" }, "isoforms": [ { "isoform_ac": "Q5E969-1", "url": "https://www.uniprot.org/uniprotkb/Q5E969/entry#Q5E969-1", "sequence": { "sequence": "MKAKPSHPAFSMSTSLRVSPSIHGYHFDTASRKKAVGNIFENIDQEALQRLFRNSGDKKAEERAKIIFAIDQDLEEKTRALMALKKRTKDKLFQFLKLRKYSIKVH", "length": 106, "header": "sp|Q5E969-1|TCIM_BOVIN Isoform 1 of Transcriptional and immune response regulator OS=Bos taurus OX=9913 GN=TCIM PE=3 SV=1 CANONICAL=Q5E969-1" }, "locus": { "chromosome": "27", "start_pos": 35232973, "end_pos": 35232656, "strand": "-", "evidence": [ { "database": "Ensembl 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"https://www.ncbi.nlm.nih.gov/protein/NP_001014931" } ] } ], "function": [ { "annotation": "Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (By similarity). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E972", "url": "https://www.uniprot.org/uniprotkb/Q5E972#function" }, { "database": "UniProtKB", "id": "Q53FV1", "url": "https://www.uniprot.org/uniprotkb/Q53FV1#function" }, { "database": "UniProtKB", "id": "Q8N138", "url": "https://www.uniprot.org/uniprotkb/Q8N138#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E972", "url": "https://www.uniprot.org/uniprotkb/Q5E972" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ORMDL2", "url": "https://www.uniprot.org/uniprotkb/Q5E972", "locus": { "chromosome": "5", "start_pos": 57446157, "end_pos": 57449119, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020663", "url": "https://www.ensembl.org/id/ENSBTAG00000020663" } ] } } ], "crossref": [ { "id": "Q5E972", "url": "https://alphafold.ebi.ac.uk/entry/Q5E972", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020663", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020663", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515878", "url": "https://www.ncbi.nlm.nih.gov/gene/515878", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007203", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007203", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515878", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515878", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "STHYTHF", "url": 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"Q5E972-1", "url": "https://www.uniprot.org/uniprotkb/Q5E972-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNVGVAHSEVNPNTRVMNSRGIWLAYIILVGLLHVVLLSIPFFSIPVVWTLTNVIHNLVMYVFLHTVKGTPFETPDQGKARLLTHWEQMDYGLQFTSSRKFLSISPIVLYLLASFYTKYDAAHFLINTASLLSVLLPKLPQFHGVRLFGINKY", "length": 153, "header": "sp|Q5E972-1|ORML2_BOVIN Isoform 1 of ORM1-like protein 2 OS=Bos taurus OX=9913 GN=ORMDL2 PE=2 SV=1 CANONICAL=Q5E972-1" }, "isoforms": [ { "isoform_ac": "Q5E972-1", "url": "https://www.uniprot.org/uniprotkb/Q5E972/entry#Q5E972-1", "sequence": { "sequence": "MNVGVAHSEVNPNTRVMNSRGIWLAYIILVGLLHVVLLSIPFFSIPVVWTLTNVIHNLVMYVFLHTVKGTPFETPDQGKARLLTHWEQMDYGLQFTSSRKFLSISPIVLYLLASFYTKYDAAHFLINTASLLSVLLPKLPQFHGVRLFGINKY", "length": 153, "header": "sp|Q5E972-1|ORML2_BOVIN Isoform 1 of ORM1-like protein 2 OS=Bos taurus OX=9913 GN=ORMDL2 PE=2 SV=1 CANONICAL=Q5E972-1" }, "locus": { "chromosome": "5", "start_pos": 57447969, "end_pos": 57446498, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027540.4", "url": "https://www.ensembl.org/id/ENSBTAT00000027540.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027540.3", "url": "https://www.ensembl.org/id/ENSBTAP00000027540.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E972", "url": "https://www.uniprot.org/uniprotkb/Q5E972" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:515878", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515878", "resource": "KEGG Pathway" }, { "id": "R-BTA-1660661", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660661", "resource": "Reactome", "description": "Sphingolipid de novo biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PZC6-1", "protein_name": "ORM1-like protein", "gene_name": "ORMDL2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNVGVAHSEVNPNTRVMSSRGIWLAYVISVAALHVILLSIPFFSIPVVWTLTNVIHNLVMYLLLHTVKGTPFETPDQGKDRLLTHWEQIDYGMQCTSSRKFLSISPVVLYLLTSFYTKYDPAHFMINTASLLSVLLPKLPQFHGVRVFGINKY", "length": 153 }, "evidence": [ { "id": "Q5E972", "url": "https://omabrowser.org/oma/group/Q5E972/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A2I4-1", "protein_name": "ORMDL sphingolipid biosynthesis regulator 2", "gene_name": "Ormdl2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRRTGNNRESADRAKVGHFLETTGVRAVPQAGRAPEAGRMNVGVAHSEVNPNTRVMNSRGIWLAYVILVGLLHVVLLSIPFFSIPVVWTLTNVIHNLAMYVFLHTVKGTPFETPDQGKARLLTHWEQMDYGLQFTSSRKFLSISPIVLYLLASFYTKYDAAHFLINTASLLSVLLPKLPQFHGVRLFGINKY", "length": 192 }, "evidence": [ { "id": "Q5E972", "url": "https://omabrowser.org/oma/group/Q5E972/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HRL3-1", "protein_name": "ORM1-like protein", "gene_name": "Ormdl2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNVGVAHSEVNPNTRVMNSRGIWLAYIVLVGLLHVVLLSIPFFSIPVVWTLTNVIHNLAMYIFLHTVKGTPFETPDQGKARLLTHWEQMDYGLQFTSSRKFLSISPIVLYLLASFYTKYDAAHFIINTASLLSVLLPKLPQFHGVRLFGINKY", "length": 153 }, "evidence": [ { "id": "Q5E972", "url": "https://omabrowser.org/oma/group/Q5E972/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P53224-1", "protein_name": "Protein ORM1", "gene_name": "ORM1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTELDYQGTAEAASTSYSRNQTDLKPFPSAGSASSSIKTTEPVKDHRRRRSSSIISHVEPETFEDENDQQLLPNMNATWVDQRGAWIIHVVIIILLKLFYNLFPGVTTEWSWTLTNMTYVIGSYVMFHLIKGTPFDFNGGAYDNLTMWEQIDDETLYTPSRKFLISVPIALFLVSTHYAHYDLKLFSWNCFLTTFGAVVPKLPVTHRLRISIPGITGRAQIS", "length": 222 }, "evidence": [ { "id": "Q5E972", "url": "https://omabrowser.org/oma/group/Q5E972/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q9CQZ0-1", "protein_name": "ORM1-like protein 2", "gene_name": "Ormdl2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNVGVAHSEVNPNTRVMNSRGIWLAYIILVGLLHVVLLSIPFFSIPVVWTLTNVIHNLAMYIFLHTVKGTPFETPDQGKARLLTHWEQMDYGLQFTSSRKFLSISPIVLYLLASFYTKYDAAHFLINTASLLSVLLPKLPQFHGVRLFGINKY", "length": 153 }, "evidence": [ { "id": "Q5E972", "url": "https://omabrowser.org/oma/group/Q5E972/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VP04-1", "protein_name": "ORM1-like protein", "gene_name": "ORMDL", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTSIAGGHGEANPNSSWLSARGFWLAYLLGLLSVHLLFLSVPFVSIPWAWTATNLLHNAAHLYFLHVIKGAPWLSTENDPSRRWTHWEQIDDGVQMTTTRKFLTAVPIVLFLLTCLYTRNNTEHFIPNFISLVVVTLPKLPQFHGVRLFNINKY", "length": 154 }, "evidence": [ { "id": "Q5E972", "url": "https://omabrowser.org/oma/group/Q5E972/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "serine palmitoyltransferase complex", "id": "GO:0017059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017059", "evidence": [ { "database": "UniProtKB", "id": "Q5E972", "url": "https://www.uniprot.org/uniprotkb/Q5E972" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": 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forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E981", "url": "https://www.uniprot.org/uniprotkb/Q5E981#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E981", "url": "https://www.uniprot.org/uniprotkb/Q5E981" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ID3", "url": "https://www.uniprot.org/uniprotkb/Q5E981", "locus": { "chromosome": "2", "start_pos": 129298367, "end_pos": 129296749, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030425", "url": "https://www.ensembl.org/id/ENSBTAG00000030425" } ] } } ], "crossref": [ { "id": "Q5E981", "url": 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"bta:538690", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538690", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PARGCYE", "url": "https://omabrowser.org/oma/group/PARGCYE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E981", "url": "https://www.orthodb.org/?gene=Q5E981", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11723", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11723", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11723:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11723:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014950", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E981", "url": "https://www.uniprot.org/uniprotkb/Q5E981", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E981-1", "url": "https://www.uniprot.org/uniprotkb/Q5E981-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKALSPVRGCYEAVCCLSERSLAIARGRGKSPAAEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAEPAPGPPDGPHLPIQTAELAPELVISNDQRSFCH", "length": 119, "header": "sp|Q5E981-1|ID3_BOVIN Isoform 1 of DNA-binding protein inhibitor ID-3 OS=Bos taurus OX=9913 GN=ID3 PE=3 SV=1 CANONICAL=Q5E981-1" }, "isoforms": [ { "isoform_ac": "Q5E981-1", "url": "https://www.uniprot.org/uniprotkb/Q5E981/entry#Q5E981-1", "sequence": { "sequence": "MKALSPVRGCYEAVCCLSERSLAIARGRGKSPAAEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAEPAPGPPDGPHLPIQTAELAPELVISNDQRSFCH", "length": 119, "header": "sp|Q5E981-1|ID3_BOVIN Isoform 1 of DNA-binding protein inhibitor ID-3 OS=Bos taurus OX=9913 GN=ID3 PE=3 SV=1 CANONICAL=Q5E981-1" }, "locus": { "chromosome": "2", "start_pos": 129297295, "end_pos": 129296819, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019148.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019148.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019148.3", "url": "https://www.ensembl.org/id/ENSBTAP00000019148.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E981", "url": "https://www.uniprot.org/uniprotkb/Q5E981" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "ID3 regulates progesterone synthesis in bovine cumulus cells through modulation of mitochondrial function.", "journal": "Theriogenology", "date": "2023-06-25", "authors": "Liu Zi-Bin, Zhang Jia-Bao, Li Sheng-Peng, Yu Wen-Jie, Pei Na, Jia Hai-Tao, Li Ze, Lv Wen-Fa, Wang Jun, Kim Nam-Hyung, Yuan Bao, Jiang Hao", "evidence": [ { "database": "RefSeq", "id": "NP_001014950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014950" } ], "reference": [ { "type": "PubMed", "id": "37393744", "url": "https://glygen.org/publication/PubMed/37393744" } ] } ], "pathway": [ { "id": "bta:538690", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538690", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BAT8-1", "protein_name": "DNA-binding protein inhibitor ID-3", "gene_name": "ID3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": 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"MKALSPVRGCYEAVCCLSERSLAIARGRGKSPSTEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAEPAPGPPDGPHLPIQTAELTPELVISKDKRSFCH", "length": 119 }, "evidence": [ { "id": "Q5E981", "url": "https://omabrowser.org/oma/group/Q5E981/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P41138-1", "protein_name": "DNA-binding protein inhibitor ID-3", "gene_name": "Id3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKALSPVRGCYEAVCCLSERSLAIARGRGKSPSAEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAEPAPGPPDGPHLPIQTAELTPELVISKDKRSFCH", "length": 119 }, "evidence": [ { "id": "Q5E981", "url": "https://omabrowser.org/oma/group/Q5E981/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q02535-1", "protein_name": "DNA-binding protein inhibitor ID-3", "gene_name": "ID3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"evidence": [ { "database": "UniProtKB", "id": "Q5E981", "url": "https://www.uniprot.org/uniprotkb/Q5E981" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "Q5E981", "url": "https://www.uniprot.org/uniprotkb/Q5E981" } ], "pmid": "" }, { "name": "bHLH transcription factor binding", "id": "GO:0043425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043425", "evidence": [ { "database": "UniProtKB", "id": "Q5E981", "url": "https://www.uniprot.org/uniprotkb/Q5E981" } ], "pmid": "" }, { "name": "transcription regulator inhibitor activity", "id": "GO:0140416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140416", "evidence": [ { "database": "UniProtKB", "id": "Q5E981", "url": "https://www.uniprot.org/uniprotkb/Q5E981" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q5E981", "url": "https://www.uniprot.org/uniprotkb/Q5E981" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q5E981", "url": "https://www.uniprot.org/uniprotkb/Q5E981" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "Q5E981", "url": "https://www.uniprot.org/uniprotkb/Q5E981" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "Q5E981", "url": "https://www.uniprot.org/uniprotkb/Q5E981" } ], "pmid": "" }, { "name": "central 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"id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E981", "url": "https://www.uniprot.org/uniprotkb/Q5E981" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q5E981", "url": "https://www.uniprot.org/uniprotkb/Q5E981" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E981", "url": "https://www.uniprot.org/uniprotkb/Q5E981" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E981-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 119, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", 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"authors" ] } ] }, { "uniprot_canonical_ac": "Q5E982-1", "uniprot_ac": "Q5E982", "uniprot_id": "DPH5_BOVIN", "mass": { "chemical_mass": 31662.0, "monoisotopic_mass": 31662.0 }, "refseq": { "ac": "NP_001070289", "name": "diphthine methyl ester synthase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070289" }, "gene_names": [ { "name": "DPH5", "type": "recommended", "evidence": [ { "id": "Q5E982", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E982" } ] }, { "name": "CGI-30", "type": "synonym", "evidence": [ { "id": "NP_001070289", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070289" } ] }, { "name": "DPH5", "type": "synonym", "evidence": [ { "id": "NP_001070289", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070289" } ] } ], "protein_names": [ { "name": "Diphthine methyl ester synthase", "type": "recommended", "evidence": [ { "id": "Q5E982", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E982/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.314", "type": "synonym", "evidence": [ { "id": "Q5E982", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E982/entry#names_and_taxonomy" } ] }, { "name": "DPH5 homolog", "type": "synonym", "evidence": [ { "id": "NP_001070289", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070289" } ] }, { "name": "Diphthamide biosynthesis methyltransferase", "type": "synonym", "evidence": [ { "id": "Q5E982", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E982/entry#names_and_taxonomy" } ] }, { "name": "diphthamide biosynthesis methyltransferase", "type": "synonym", "evidence": [ { "id": "NP_001070289", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070289" } ] }, { "name": "diphthine methyl ester synthase", "type": "synonym", "evidence": [ { "id": "NP_001070289", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070289" } ] }, { "name": "diphthine synthase", "type": "synonym", "evidence": [ { "id": "NP_001070289", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070289" } ] } ], "function": [ { "annotation": "S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.", "evidence": [ { "database": "UniProtKB", "id": "Q5E982", "url": "https://www.uniprot.org/uniprotkb/Q5E982#function" }, { "database": "UniProtKB", "id": "P32469", "url": "https://www.uniprot.org/uniprotkb/P32469#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E982", "url": "https://www.uniprot.org/uniprotkb/Q5E982" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DPH5", "url": "https://www.uniprot.org/uniprotkb/Q5E982", "locus": { "chromosome": "3", "start_pos": 42298751, "end_pos": 42259116, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019029", "url": "https://www.ensembl.org/id/ENSBTAG00000019029" } ] } } ], "crossref": [ { "id": "Q5E982", "url": "https://alphafold.ebi.ac.uk/entry/Q5E982", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019029", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019029", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11647", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11647", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508904", "url": "https://www.ncbi.nlm.nih.gov/gene/508904", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004551", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004551", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014776", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014776", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014777", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014777", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035996", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035996", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508904", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508904", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HNASIMS", "url": "https://omabrowser.org/oma/group/HNASIMS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E982", "url": "https://www.orthodb.org/?gene=Q5E982", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10882", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10882", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10882:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10882:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00590", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00590", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5358493", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5358493", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001070289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070289", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "42652", "url": "https://www.rhea-db.org/rhea/42652", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E982", "url": "https://www.uniprot.org/uniprotkb/Q5E982", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E982-1", "url": "https://www.uniprot.org/uniprotkb/Q5E982-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLYMIGLGLGDAKDITVKGLEVVRRCSRVYLETYTSVLTVGKEVLEEFYERKLILADREEVEQEADNILKDADISDVAFLVVGDPFGATTHSDLILRATKLGIPYRVIHNASIMNAVGCCGLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRKIYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGAEDQKIAAGTLQQMSTVDLGGPLHSLIITGGSLHPLEMEMLSLFTIPENSSEAQSIGGL", "length": 285, "header": "sp|Q5E982-1|DPH5_BOVIN Isoform 1 of Diphthine methyl ester synthase OS=Bos taurus OX=9913 GN=DPH5 PE=2 SV=1 CANONICAL=Q5E982-1" }, "isoforms": [ { "isoform_ac": "Q5E982-1", "url": "https://www.uniprot.org/uniprotkb/Q5E982/entry#Q5E982-1", "sequence": { "sequence": "MLYMIGLGLGDAKDITVKGLEVVRRCSRVYLETYTSVLTVGKEVLEEFYERKLILADREEVEQEADNILKDADISDVAFLVVGDPFGATTHSDLILRATKLGIPYRVIHNASIMNAVGCCGLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRKIYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGAEDQKIAAGTLQQMSTVDLGGPLHSLIITGGSLHPLEMEMLSLFTIPENSSEAQSIGGL", "length": 285, "header": "sp|Q5E982-1|DPH5_BOVIN Isoform 1 of Diphthine methyl ester synthase OS=Bos taurus OX=9913 GN=DPH5 PE=2 SV=1 CANONICAL=Q5E982-1" }, "locus": { "chromosome": "3", "start_pos": 42298070, "end_pos": 42259419, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145777.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145777.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106317.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106317.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 171, "end_pos": 171, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E982", "url": "https://www.uniprot.org/uniprotkb/Q5E982" } ], "site_lbl": "Ser171" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E982", "url": "https://www.uniprot.org/uniprotkb/Q5E982" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:508904", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508904", "resource": "KEGG Pathway" }, { "id": "R-BTA-5358493", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5358493", "resource": "Reactome", "description": "Synthesis of diphthamide-EEF2" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4IU56-1", "protein_name": "diphthine methyl ester synthase", "gene_name": "dph5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLYLVGLGLGDAKDITVKGLEIIRKCSRVYLEAYTSILTVGKDALEEYYGRELLLADRDMVEQEADEILKGADVCDVAFLVVGDPFGATTHSDLVLRALNAGIQYRVIHNASIMNAVGCCGLQLYNFGETVSIVFWTDTWRPESFYDKIKKNRDMGLHTLCLLDIKVKEQSMENLMRGRKIYEPPRYMTVAQAAEQLLEILQNRRDRGEELAMTEDTVCVGLARVGAEDQTIRSGTLRELASCDLEGPLHSLIISGHLHPLEVDMLKLFSSPEGLKSLKMTDSSTYVS", "length": 288 }, "evidence": [ { "id": "Q5E982", "url": "https://omabrowser.org/oma/group/Q5E982/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1P418-1", "protein_name": "diphthine methyl ester synthase", "gene_name": "DPH5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLYLVGLGLGDAKDITVKGLEVVRRCRRVYLEAYTSVLTVGKEALEEFYGKELILADRETVEQEADSILKDADVCDVAFLVVGDPFGATTHSDLVLRAVQLGIPYQVIHNASIMNAVGCCGLQLYNFGETVSIVFWTDTWKPESFFDKIKRNRQNGMHTLCLLDIKVKEQSLDNLMKGRKIYEPSRYMSVNQAAEQLLDIIRNRRLQGEEPEITENTICVGLARVGAPDQKIASGTLYQMSTVELGGPLHSMIVTGTMHPLELEMLKLFSVDSSNFENNAFQKTT", "length": 285 }, "evidence": [ { "id": "Q5E982", "url": "https://omabrowser.org/oma/group/Q5E982/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S569-1", "protein_name": "diphthine methyl ester synthase", "gene_name": "DPH5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLYMIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSILTVGKEVLEEFYGRKLILADREEVEQEADNILKDADIGDVAFLVVGDPFGATTHSDLILRATKLGIPYRVIHNASIMNAVGCCGLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRLNGMHTLCLLDIKVKEQSLENLIKGRKIYEPPRYMSVNQAAQQLLEIVQNQRMRGEEPAVTEETLCVGLARVGAEDQKIAAGTLQQMCTVDLGGPLHSLIITGGSLHPLEMEMLRLFSIPEDSSESQSTDAL", "length": 285 }, "evidence": [ { "id": "Q5E982", "url": "https://omabrowser.org/oma/group/Q5E982/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O81769-1", "protein_name": "Probable diphthine methyl ester synthase", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MLYIIGLGLGDEKDITLRGLEAVKKSQKVYMEAYTSLLSFGLSADGLSNLEKFYGKPIILADREMVEEKAGDMIDEAIDNDVAFLVVGDPFGATTHSDLVVRAKTLGVKVEVVHNASVMNAVGICGLQLYHYGETVSIPFFTETWRPDSFYEKIKKNRSLGLHTLCLLDIRVKEPTFESLCRGGKKQYEPPRYMSVNTAIEQLLEVEQKHGDSVYGEDTQCVGFARLGSEDQTIVAGTMKQLESVDFGAPLHCLVIVGETHPVEEEMLEFYKYKSGN", "length": 277 }, "evidence": [ { "id": "Q5E982", "url": "https://omabrowser.org/oma/group/Q5E982/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P32469-1", "protein_name": "Diphthine methyl ester synthase", "gene_name": "DPH5", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MLYLIGLGLSYKSDITVRGLEAIKKCSRVYLEHYTSILMAASQEELESYYGKEIILADRELVETGSKQILNNADKEDVAFLVVGDPFGATTHTDLVLRAKREAIPVEIIHNASVMNAVGACGLQLYNFGQTVSMVFFTDNWRPDSWYDKIWENRKIGLHTLVLLDIKVKEQSIENMARGRLIYEPPRYMSIAQCCEQLLEIEEKRGTKAYTPDTPAVAISRLGSSSQSFKSGTISELANYDSGEPLHSLVILGRQCHELELEYLLEFADDKEKFGKDVANDQEYFKPAAWVPPTEDDSDE", "length": 300 }, "evidence": [ { "id": "Q5E982", "url": "https://omabrowser.org/oma/group/Q5E982/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q75JG8-1", "protein_name": "Diphthine methyl ester synthase", "gene_name": "dph5", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MVLYIIGLGLGDEKDVTIKGFEAIKKSSKIYLEAYTSLLGGSTSIEALEKFYEKKIIIADREMVESGCEEMLKESTENDVSFLVVGDPFGATTHTDLVIRAKELSIPVKVIHNASIMNAIGCCGLQLYSYGQTISMVFFTETTKPDSWYDRVKINRVNGMHTLCLLDIKVKEQSIENMCRGRLIYEPPRFMTVNQCIEQLLEIEEIRKEKVYDQDTLCIGLSRVGQDDQQIISGTMKELLDVDFGAPLHSFIICGDMHFIEKEYFETFRVKKN", "length": 273 }, "evidence": [ { "id": "Q5E982", "url": "https://omabrowser.org/oma/group/Q5E982/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8IN02-1", "protein_name": "diphthine methyl ester synthase", "gene_name": "Dph5", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFYLIGLGLGDLKDITVKGLEIVKQCSRVYLEMYTSILGCSLEDMQEFYGRPLLLADRDLVEQGADEILAGAGESDVALLVVGDPFGATTHTDFILRAKEKNIPYKVIHNASIMNAVGCCGLQLYKFGETVSIPYWDETWKPDSFYDKIKLNRLHNMHTLCLLDIKVKEPTPESLMRKRKEYMPPRFMTVAEAAHQLLSIVEKKDSLEKNTVLNEQSLCVGLARVGQESQQIAVGTLLEMRSTDLGGPLHSLIIPAKEMHPLEVEFLQQYAPSIKLDDYNH", "length": 281 }, "evidence": [ { "id": "Q5E982", "url": "https://omabrowser.org/oma/group/Q5E982/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9CWQ0-1", "protein_name": "Diphthine methyl ester synthase", "gene_name": "Dph5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLILADREEVEQEADNIFKDADVSDVAFLVVGDPFGATTHSDLILRATKLGIPYQVIHNASIMNAVGCCGLQLYRFGETVSIVFWTDTWRPESFFDKVKRNRANGMHTLCLLDIKVKEQSLENLIRGRKIYEPPRYMSVNQAAQQLLEIVQNHRARGEEPAITEETLCVGLARVGAEDQKIAAGTLQQMCTVSLGEPLHSLVITGGNLHPLEMEMLSLFSIPESQSTDGL", "length": 281 }, "evidence": [ { "id": "Q5E982", "url": "https://omabrowser.org/oma/group/Q5E982/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H2P9-1", "protein_name": "Diphthine methyl ester synthase", "gene_name": "DPH5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREEVEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCCGLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRKIYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSINGL", "length": 285 }, "evidence": [ { "id": "Q5E982", "url": "https://omabrowser.org/oma/group/Q5E982/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "diphthine synthase activity", "id": "GO:0004164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004164", "evidence": [ { "database": "UniProtKB", "id": "Q5E982", "url": "https://www.uniprot.org/uniprotkb/Q5E982" } ], "pmid": "" }, { "name": "diphthine methyl ester synthase activity", "id": "GO:0141133", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141133", "evidence": [ { "database": "UniProtKB", "id": "Q5E982", "url": "https://www.uniprot.org/uniprotkb/Q5E982" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5E982", "url": "https://www.uniprot.org/uniprotkb/Q5E982" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "Q5E982", "url": "https://www.uniprot.org/uniprotkb/Q5E982" } ], "pmid": "" }, { "name": "protein histidyl modification to diphthamide", "id": "GO:0017183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017183", "evidence": [ { "database": "UniProtKB", "id": "Q5E982", "url": "https://www.uniprot.org/uniprotkb/Q5E982" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 275, "end_pos": 277, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "42652", "name": "", "equation": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E982-1" ], "evidence": [ { "id": "42652", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42652" } ] }, { "id": "R-BTA-5358484", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-BTA-5358478" ], "output_participant_list": [ "R-BTA-5367025" ], "enzyme_list": [ "Q3SYU2-1", "Q5E982-1" ], "evidence": [ { "id": "R-BTA-5358484", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5358484" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-5358478", "participant_name": "aminocarboxypropyl EEF2 [cytosol]", "crossref": [ { "id": "Q3SYU2", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000004258", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000005581", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000005581", "database": "ENSEMBL", "url": "" }, { "id": "NP_001068589.1", "database": "RefSeq", "url": "" }, { "id": "28335", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-5367025", "participant_name": "Me-diphthine EEF2 [cytosol]", "crossref": [ { "id": "NP_001068589.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAP00000005581", "database": "ENSEMBL", "url": "" }, { "id": "Q3SYU2", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000004258", "database": "ENSEMBL", "url": "" }, { "id": "28335", "database": "VGNC", "url": "" }, { "id": "ENSBTAT00000005581", "database": "ENSEMBL", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q5E982", "gene_name": "DPH5", "activity": [ { "ec_number": "2.1.1.314", "activity": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "Q5E982", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E982" } ] }, { "ec_number": "2.1.1.314", "activity": "", "evidence": [ { "id": "Q5E982", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E982" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E982-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 285, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E982-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E982" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.1.1.314", "ec_name": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+).", "evidence": [ { "id": "2.1.1.314", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.314" }, { "id": "2.1.1.314", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.314" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 171 ], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 }, { "start_pos": 275, "end_pos": 277 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E984-1", "uniprot_ac": "Q5E984", "uniprot_id": "TCTP_BOVIN", "mass": { "chemical_mass": 19581.0, "monoisotopic_mass": 19581.0 }, "refseq": { "ac": "NP_001014410", "name": "translationally-controlled tumor protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014410" }, "gene_names": [ { "name": "TPT1", "type": "recommended", "evidence": [ { "id": "Q5E984", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E984" } ] }, { "name": "TCTP", "type": "synonym", "evidence": [ { "id": "NP_001014410", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014410" } ] }, { "name": "TPT1", "type": "synonym", "evidence": [ { "id": "NP_001014410", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014410" } ] } ], "protein_names": [ { "name": "Translationally-controlled tumor protein", "type": "recommended", "evidence": [ { "id": "Q5E984", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E984/entry#names_and_taxonomy" } ] }, { "name": "TCTP", "type": "synonym", "evidence": [ { "id": "Q5E984", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E984/entry#names_and_taxonomy" } ] }, { "name": "translationally-controlled tumor protein", "type": "synonym", "evidence": [ { "id": "NP_001014410", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014410" } ] } ], "function": [ { "annotation": "Involved in calcium binding and microtubule stabilization (By similarity). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E984", "url": "https://www.uniprot.org/uniprotkb/Q5E984#function" }, { "database": "UniProtKB", "id": "P13693", "url": "https://www.uniprot.org/uniprotkb/P13693#function" } ] }, { "annotation": "Pretreatment of donor cells with phosphorylated TCTP peptide has a beneficial effect on the potential of bovine somatic cell nuclei to develop into normal cloned calves.", "evidence": [ { "database": "RefSeq", "id": "NP_001014410", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014410" }, { "database": "PubMed", "id": "17579559", "url": "https://glygen.org/publication/PubMed/17579559" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E984", "url": "https://www.uniprot.org/uniprotkb/Q5E984" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TPT1", "url": "https://www.uniprot.org/uniprotkb/Q5E984", "locus": {} } ], "crossref": [ { "id": "Q5E984", "url": "https://alphafold.ebi.ac.uk/entry/Q5E984", "database": "AlphaFoldDB", "categories": [] }, { "id": "326599", "url": "https://www.ncbi.nlm.nih.gov/gene/326599", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011323", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011323", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018105", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018105", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034737", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034737", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:326599", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:326599", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E984", "url": "https://www.orthodb.org/?gene=Q5E984", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11991", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11991", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11991:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11991:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00838", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00838", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014410", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014410", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E984", "url": "https://www.uniprot.org/uniprotkb/Q5E984", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E984-1", "url": "https://www.uniprot.org/uniprotkb/Q5E984-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIIYRDLISHDEMFSDIYKIREVADGLCLEVEGKMVSRTEGNIDDSLIGGNASAEGPEGEGTESTVITGVDIVMNHHLQETSFTKEAYKKYIKDYMKSIKGKLEEQRPERVKPFMTGAAEQIKHILANFKNYQFFIGENMNPDGMVALLDYREDGVTPYMIFFKDGLEMEKC", "length": 172, "header": "sp|Q5E984-1|TCTP_BOVIN Isoform 1 of Translationally-controlled tumor protein OS=Bos taurus OX=9913 GN=TPT1 PE=2 SV=1 CANONICAL=Q5E984-1" }, "isoforms": [ { "isoform_ac": "Q5E984-1", "url": "https://www.uniprot.org/uniprotkb/Q5E984/entry#Q5E984-1", "sequence": { "sequence": "MIIYRDLISHDEMFSDIYKIREVADGLCLEVEGKMVSRTEGNIDDSLIGGNASAEGPEGEGTESTVITGVDIVMNHHLQETSFTKEAYKKYIKDYMKSIKGKLEEQRPERVKPFMTGAAEQIKHILANFKNYQFFIGENMNPDGMVALLDYREDGVTPYMIFFKDGLEMEKC", "length": 172, "header": "sp|Q5E984-1|TCTP_BOVIN Isoform 1 of Translationally-controlled tumor protein OS=Bos taurus OX=9913 GN=TPT1 PE=2 SV=1 CANONICAL=Q5E984-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 46, "end_pos": 46, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; 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} ] } } ], "crossref": [ { "id": "Q5E993", "url": "https://alphafold.ebi.ac.uk/entry/Q5E993", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010006", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010006", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616813", "url": "https://www.ncbi.nlm.nih.gov/gene/616813", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039856", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039856", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055217", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616813", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616813", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MSDQEGW", "url": "https://omabrowser.org/oma/group/MSDQEGW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E993", "url": "https://www.orthodb.org/?gene=Q5E993", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12760", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12760", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF22890", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22890", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001073796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073796", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E993", "url": "https://www.uniprot.org/uniprotkb/Q5E993", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E993-1", "url": "https://www.uniprot.org/uniprotkb/Q5E993-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKVSELYDVTWEEMRDKMRKWREENSRNSEQIVEVGEELISEYASKLGDDIWIIYEQVMIAALDYGRDDLALFCLQELRRQFPGSHRVKRLTGMRFEAMERYDDAIQLYDRILQEDPTNTAARKRKIAIRKAQGKNVEAIRELNEYLEQFVGDQEAWHELAELYINEHDYAKAAFCLEELMMTNPYNHLYCQQYAEVKYTQGGLENLELSRKYFAQALKLNNRNMRALFGLYMSASHIASNPKASAKTKKDNMKYASWAASQINKAYQFAGRSKKETKYSLKAVEDMLETLQITQS", "length": 297, "header": "sp|Q5E993-1|EMC2_BOVIN Isoform 1 of ER membrane protein complex subunit 2 OS=Bos taurus OX=9913 GN=EMC2 PE=2 SV=1 CANONICAL=Q5E993-1" }, "isoforms": [ { "isoform_ac": "Q5E993-1", "url": "https://www.uniprot.org/uniprotkb/Q5E993/entry#Q5E993-1", "sequence": { "sequence": "MAKVSELYDVTWEEMRDKMRKWREENSRNSEQIVEVGEELISEYASKLGDDIWIIYEQVMIAALDYGRDDLALFCLQELRRQFPGSHRVKRLTGMRFEAMERYDDAIQLYDRILQEDPTNTAARKRKIAIRKAQGKNVEAIRELNEYLEQFVGDQEAWHELAELYINEHDYAKAAFCLEELMMTNPYNHLYCQQYAEVKYTQGGLENLELSRKYFAQALKLNNRNMRALFGLYMSASHIASNPKASAKTKKDNMKYASWAASQINKAYQFAGRSKKETKYSLKAVEDMLETLQITQS", "length": 297, "header": "sp|Q5E993-1|EMC2_BOVIN Isoform 1 of ER membrane protein complex subunit 2 OS=Bos taurus OX=9913 GN=EMC2 PE=2 SV=1 CANONICAL=Q5E993-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E993", "url": "https://www.uniprot.org/uniprotkb/Q5E993" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:616813", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616813", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2UDL9-1", "protein_name": "ER membrane protein complex subunit 2", "gene_name": "EMC2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAKVSEMYDVTWEDMRDKMRKWREENYRNSEQIVDVGEELINEYASKLGDDIWIIYEQVMIAALDCSRDDLALFCLQELRRQFPGSHRVKRLTGMRFEAMERYDDAIQLYDRILQEDATNTAARKRKIAIRKAQGKNLEAIRELNEYLEQFVGDQEAWHELAELYINEHDYAKAAFCLEELMMANPHNHLYCQQYAEVKYTQGGLENLELSRKYFAQALKLNNRNMRALFGLYMSASHIASNPKASAKMKKDNMKYASWAANQINRAYQFAGRSKKETKYSLKAVEDMLETLQITQS", "length": 297 }, "evidence": [ { "id": "Q5E993", "url": "https://omabrowser.org/oma/group/Q5E993/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B0BNG0-1", "protein_name": "ER membrane protein complex subunit 2", "gene_name": "Emc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAKVTERYDVTWEEMRDKMRKWREENSRNSEQIMEVGEELINDYASKLGDDIWIIYEQVMIAALDYGRDDLALFCLQELRRQFPGSHRVKRLTGMRFEAMERYDDAIQLYDRILQEDPTNTAARKRKIAIRKAQGKNVEAIRELNEYLEQFVGDQEAWHELAELYINEHDYAKAAFCLEELMMTNPHNHLYCQQYAEVKYTQGGLENLELSRKYFAQALKLNNRNMRALFGLYMSASHIASNPKASAKMKKDNIRYAGWAANQINRAYQFAGRSKKETKSSLKAVEDMLETLQITQS", "length": 297 }, "evidence": [ { "id": "Q5E993", "url": "https://omabrowser.org/oma/group/Q5E993/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q15006-1", "protein_name": "ER membrane protein complex subunit 2", "gene_name": "EMC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKVSELYDVTWEEMRDKMRKWREENSRNSEQIVEVGEELINEYASKLGDDIWIIYEQVMIAALDYGRDDLALFCLQELRRQFPGSHRVKRLTGMRFEAMERYDDAIQLYDRILQEDPTNTAARKRKIAIRKAQGKNVEAIRELNEYLEQFVGDQEAWHELAELYINEHDYAKAAFCLEELMMTNPHNHLYCQQYAEVKYTQGGLENLELSRKYFAQALKLNNRNMRALFGLYMSASHIASNPKASAKTKKDNMKYASWAASQINRAYQFAGRSKKETKYSLKAVEDMLETLQITQS", "length": 297 }, "evidence": [ { "id": "Q5E993", "url": "https://omabrowser.org/oma/group/Q5E993/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6TGY8-1", "protein_name": "ER membrane protein complex subunit 2", "gene_name": "emc2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSSISELYDVTWEEMRDKLRKWREENYRNSEQIVDVGEELINEHASKLGDDIWIIYEQVMIAALDCSRDDLAWSCLQELKRQFPDSHRVKRLAGMRLEALERYDDANKLYDSILQDDPTNTAARKRKICILRAQGKSSEAIRELNEYLEQFVGDQEAWHELSELYINEHDYAKAAFCLEELMMTNPHNHLYCEQYAEVKYTQGGLENLELARKYFAQALKLNNRNMRALFGLYMSASHIAASPKVSAKVKKDNVKYAAWAAAQISRAYQMAGRGKKENKCSVKAVEEMLESLQITMS", "length": 297 }, "evidence": [ { "id": "Q5E993", "url": "https://omabrowser.org/oma/group/Q5E993/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q86K48-1", "protein_name": "ER membrane protein complex subunit 2", "gene_name": "emc2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSEMLMLTSSDSIEINRYEEGIRNSGRSFNWVLVRDTLRFLRKSKIRKSNLVSKYGLKLVTQYFNKLEDQEGYDTIEQVIVACLDCGDHTNPKKLFEQLKSKFGKDSVRVQRIHALCLESNNQLAEALQIFESILKKYPSDALSMKRQVAIFKGQGNLSKAIQVLNAYLQIYMCDLEAWLELSSFHISYLSYSTALYCLEEVLLNAPINFVFYIKYAEPLYCLGGNENYNSAVQYYTHALELNSPTEMDKLDHPPTFLPAIYGIIMSIYSLCEEGYQLKESQLKLMEWAQNNLLTITKKYSSNDKINLVKHFIDSTDIFNKE", "length": 322 }, "evidence": [ { "id": "Q5E993", "url": "https://omabrowser.org/oma/group/Q5E993/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9CAU9-1", "protein_name": "ER membrane protein complex subunit 2", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVTKTEEIQLNQLENQVENGGGGVWEYLCLVRKLKVRRSEIVLKHGLSILNDSGKRSALGPDEWTLYEQVAIAAMDCQSLGVAQNCIKVLKKKFPESKRVGKLEALLLEAKGMWEEAEKAYTSLLEDNPLDQVIHKRKVAMAKAQGKSSLAIEHLNKYLEVFMADHDAWRELAEIYVSLQMYKQAAFCYEELILTQPTLPLYHLAYADVLYTIGGLENLIAARKYYAATIDLTGGKSTRALLGICLCGSAIAQISKGRNKEDKDMAAPELQSLAATALEREYKQKAPAKLNLLTSALRNLKIA", "length": 303 }, "evidence": [ { "id": "Q5E993", "url": "https://omabrowser.org/oma/group/Q5E993/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9CRD2-1", "protein_name": "ER membrane protein complex subunit 2", "gene_name": "Emc2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKVTERYDVTWEEMRDKMRKWREENSRNSEQIMEVGEELINDYASKLGDDIWIIYEQVMIAALDYGRDDLALFCLQELRRQFPGSHRVKRLTGMRFEAMERYDDAIQLYDRILQEDPTNTAARKRKIAIRKAQGKTVEAIRELNEYLEQFVGDQEAWHELAELYINEHDYAKAAFCLEELMMTNPHNHLYCQQYAEVKYTQGGLENLELSRKYFAQALKLNNRNMRALFGLYMSASHIASNPKASAKMKKDNIKYASWAANQINRAYQFAGRSKKETKYSLKAVEDMLETLQITQS", "length": 297 }, "evidence": [ { "id": "Q5E993", "url": "https://omabrowser.org/oma/group/Q5E993/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VEQ1-1", "protein_name": "ER membrane protein complex subunit 2", "gene_name": "EMC2A", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSLDYEKMSWSDVRDQFRTWREETGRHSEEVVQLWVAVLEDKVHKTGNERHLILEQVIIAALDTARFDIATKCTKQLSLEFPGSLRVMKFKAMRYEALEQYDEADEVLDAIIAKDETNAAPRKRKIAILKARGRRLEAIKELNEYLKKFMSDQEAWHELCNMYLAEGEFGKAAFCMEEVLLHNPHSHLIHQRLAEIRYTMGGVENMESARTYYSQALKLNPHNLRALYGIYLCCNHLDNSRAVSSKRKELQKLSQWALEQLLTKQTIVPLEAAFGNLEIKSN", "length": 282 }, "evidence": [ { "id": "Q5E993", "url": "https://omabrowser.org/oma/group/Q5E993/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "EMC complex", "id": "GO:0072546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072546", "evidence": [ { "database": "UniProtKB", "id": "Q5E993", "url": "https://www.uniprot.org/uniprotkb/Q5E993" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E993", "url": "https://www.uniprot.org/uniprotkb/Q5E993" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q5E993", "url": "https://www.uniprot.org/uniprotkb/Q5E993" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q5E993", "url": "https://www.uniprot.org/uniprotkb/Q5E993" } ], "pmid": "" }, { "name": "extrinsic component of endoplasmic reticulum membrane", "id": "GO:0042406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042406", "evidence": [ { "database": "UniProtKB", "id": "Q5E993", "url": "https://www.uniprot.org/uniprotkb/Q5E993" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "tail-anchored membrane protein insertion into ER membrane", "id": "GO:0071816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071816", "evidence": [ { "database": "UniProtKB", "id": "Q5E993", "url": "https://www.uniprot.org/uniprotkb/Q5E993" } ], "pmid": "" }, { "name": "protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "id": "GO:0045050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045050", "evidence": [ { "database": "UniProtKB", "id": "Q5E993", "url": "https://www.uniprot.org/uniprotkb/Q5E993" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E993-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 297, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E993-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E993" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": 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"count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E994-1", "uniprot_ac": "Q5E994", "uniprot_id": "CHM1B_BOVIN", "mass": { "chemical_mass": 22022.0, "monoisotopic_mass": 22022.0 }, "refseq": { "ac": "NP_001014904", "name": "charged multivesicular body protein 1b", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014904" }, "gene_names": [ { "name": "CHMP1B", "type": "recommended", "evidence": [ { "id": "Q5E994", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ] }, { "name": "CHMP1.5", "type": "synonym", "evidence": [ { "id": "NP_001014904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014904" } ] }, { "name": "CHMP1B", "type": "synonym", "evidence": [ { "id": "NP_001014904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014904" } ] } ], "protein_names": [ { "name": "Charged multivesicular body protein 1b", "type": "recommended", "evidence": [ { "id": "Q5E994", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E994/entry#names_and_taxonomy" } ] }, { "name": "CHMP1b", "type": "synonym", "evidence": [ { "id": "Q5E994", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E994/entry#names_and_taxonomy" } ] }, { "name": "Chromatin-modifying protein 1b", "type": "synonym", "evidence": [ { "id": "Q5E994", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E994/entry#names_and_taxonomy" } ] }, { "name": "charged multivesicular body protein 1b", "type": "synonym", "evidence": [ { "id": "NP_001014904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014904" } ] }, { "name": "chromatin modifying protein 1B", "type": "synonym", "evidence": [ { "id": "NP_001014904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014904" } ] }, { "name": "chromatin-modifying protein 1b", "type": "synonym", "evidence": [ { "id": "NP_001014904", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014904" } ] } ], "function": [ { "annotation": "Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHMP1B", "url": "https://www.uniprot.org/uniprotkb/Q5E994", "locus": {} } ], "crossref": [ { "id": "Q5E994", "url": "https://alphafold.ebi.ac.uk/entry/Q5E994", "database": "AlphaFoldDB", "categories": [] }, { "id": "512033", "url": "https://www.ncbi.nlm.nih.gov/gene/512033", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512033", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512033", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E994", "url": "https://www.orthodb.org/?gene=Q5E994", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10476", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10476", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03357", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03357", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014904", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E994-1", "url": "https://www.uniprot.org/uniprotkb/Q5E994-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSNMEKHLFNLKFAAKELGRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQGQVDMLLQEMADEAGLDLNMELPQGQTGSVGTSVASAEQDELSQRLARLRDQV", "length": 199, "header": "sp|Q5E994-1|CHM1B_BOVIN Isoform 1 of Charged multivesicular body protein 1b OS=Bos taurus OX=9913 GN=CHMP1B PE=2 SV=1 CANONICAL=Q5E994-1" }, "isoforms": [ { "isoform_ac": "Q5E994-1", "url": "https://www.uniprot.org/uniprotkb/Q5E994/entry#Q5E994-1", "sequence": { "sequence": "MSNMEKHLFNLKFAAKELGRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQGQVDMLLQEMADEAGLDLNMELPQGQTGSVGTSVASAEQDELSQRLARLRDQV", "length": 199, "header": "sp|Q5E994-1|CHM1B_BOVIN Isoform 1 of Charged multivesicular body protein 1b OS=Bos taurus OX=9913 GN=CHMP1B PE=2 SV=1 CANONICAL=Q5E994-1" }, "locus": { "chromosome": "24", "start_pos": 42710034, "end_pos": 42709438, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152614.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152614.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105758.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105758.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:512033", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512033", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 11, "go_terms": [ { "name": "ESCRT III complex", "id": "GO:0000815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000815", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "kinetochore microtubule", "id": "GO:0005828", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005828", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "membrane coat", "id": "GO:0030117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030117", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "multivesicular body", "id": "GO:0005771", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005771", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "multivesicular body membrane", "id": "GO:0032585", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032585", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "amphisome membrane", "id": "GO:1904930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904930", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "plasma membrane repair", "id": "GO:0001778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001778", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "regulation of centrosome duplication", "id": "GO:0010824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010824", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "nuclear membrane reassembly", "id": "GO:0031468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031468", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "viral budding via host ESCRT complex", "id": "GO:0039702", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0039702", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "autophagosome maturation", "id": "GO:0097352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097352", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "mitotic metaphase chromosome alignment", "id": "GO:0007080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007080", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "late endosome to lysosome transport", "id": "GO:1902774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902774", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "regulation of mitotic spindle assembly", "id": "GO:1901673", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901673", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "late endosome to vacuole transport", "id": "GO:0045324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045324", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "endosome transport via multivesicular body sorting pathway", "id": "GO:0032509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032509", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "id": "GO:0043162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043162", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "viral budding from plasma membrane", "id": "GO:0046761", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046761", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "midbody abscission", "id": "GO:0061952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061952", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" }, { "name": "MIT domain binding", "id": "GO:0090541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090541", "evidence": [ { "database": "UniProtKB", "id": "Q5E994", "url": "https://www.uniprot.org/uniprotkb/Q5E994" } ], "pmid": "" } ] } ] }, "pro_annotation": [], 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May have an important role in corneal physiology (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E998", "url": "https://www.uniprot.org/uniprotkb/Q5E998#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E998", "url": "https://www.uniprot.org/uniprotkb/Q5E998" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CTSV", "url": "https://www.uniprot.org/uniprotkb/Q5E998", "locus": { "chromosome": "8", "start_pos": 83553400, "end_pos": 83558493, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017077", "url": "https://www.ensembl.org/id/ENSBTAG00000017077" } ] } } ], "crossref": [ { "id": "Q5E998", "url": "https://alphafold.ebi.ac.uk/entry/Q5E998", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02248", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02248", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000668", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000668", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025661", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025661", "database": "InterPro", 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"MNPSFFLTVLCLGVASAAPKLDPNLDAHWHQWKATHRRLYGMNEEEWRRAVWEKNKKIIDLHNQEYSEGKHGFRMAMNAFGDMTNEEFRQVMNGFQNQKHKKGKLFHEPLLVDVPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGCLDSEESYPYLATDTNSCNYKPECSAANDTGFVDIPQREKALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSNNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV", "length": 334, "header": "sp|Q5E998-1|CATL2_BOVIN Isoform 1 of Cathepsin L2 OS=Bos taurus OX=9913 GN=CTSV PE=2 SV=1 CANONICAL=Q5E998-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 222, "start_aa": "Asn", "end_pos": 222, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn222", "evidence": [ { "id": "Q5E998", "database": "UniProtKB", "url": 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"evidence": [ { "id": "NP_001014875", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014875" } ] }, { "name": "phosphatase that interacts with RNA/RNP complex 1", "type": "synonym", "evidence": [ { "id": "NP_001014875", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014875" } ] } ], "function": [ { "annotation": "Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.", "evidence": [ { "database": "UniProtKB", "id": "Q5E999", "url": "https://www.uniprot.org/uniprotkb/Q5E999#function" }, { "database": "UniProtKB", "id": "O75319", "url": "https://www.uniprot.org/uniprotkb/O75319#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E999", "url": "https://www.uniprot.org/uniprotkb/Q5E999" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DUSP11", "url": "https://www.uniprot.org/uniprotkb/Q5E999", "locus": { "chromosome": "11", "start_pos": 10864268, "end_pos": 10848281, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033255", "url": "https://www.ensembl.org/id/ENSBTAG00000033255" } ] } } ], "crossref": [ { "id": "Q5E999", "url": 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"url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508944", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508944", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E999", "url": "https://www.orthodb.org/?gene=Q5E999", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10367", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10367", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10367:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10367:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00782", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00782", "database": 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"glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 157, "end_pos": 159 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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Recent studies have shown that two protein isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism, and that these C-terminally distinct isoforms have different subcellular localization. Pseudogenes have been identified on chromosomes 1 and 11. [provided by RefSeq, Oct 2015].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303267" }, "gene_names": [ { "name": "LDHB", "type": "recommended", "evidence": [ { "id": "Q5E9B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1" } ] }, { "name": "LDHB", "type": "synonym", "evidence": [ { "id": "NP_001303267", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303267" } ] } ], "protein_names": [ { "name": "L-lactate dehydrogenase B chain", "type": "recommended", "evidence": [ { "id": "Q5E9B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1/entry#names_and_taxonomy" } ] }, { "name": "1.1.1.27", "type": "synonym", "evidence": [ { "id": "Q5E9B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1/entry#names_and_taxonomy" } ] }, { "name": "L-lactate dehydrogenase B chain isoform LDHBx", "type": "synonym", "evidence": [ { "id": "NP_001303267", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303267" } ] }, { "name": "L-lactate dehydrogenase B chain", "type": "synonym", "evidence": [ { "id": "NP_001303267", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303267" } ] }, { "name": "LDH-B", "type": "synonym", "evidence": [ { "id": "NP_001303267", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303267" }, { "id": "Q5E9B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B1", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1#function" }, { "database": "UniProtKB", "id": "P07195", "url": "https://www.uniprot.org/uniprotkb/P07195#function" } ] }, { "annotation": "This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Recent studies have shown that two protein isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism, and that these C-terminally distinct isoforms have different subcellular localization. Pseudogenes have been identified on chromosomes 1 and 11. [provided by RefSeq, Oct 2015].", "evidence": [ { "database": "RefSeq", "id": "NP_001303267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303267" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9B1", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LDHB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1", "locus": { "chromosome": "5", "start_pos": 88562770, "end_pos": 88544523, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019603", "url": "https://www.ensembl.org/id/ENSBTAG00000019603" } ] } } ], "crossref": [ { "id": "Q5E9B1", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9B1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019603", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019603", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "1.1.1.27", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.1.1.27&UniProtAcc=Q5E9B1", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd05293", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05293", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "281275", "url": "https://www.ncbi.nlm.nih.gov/gene/281275", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001557", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001557", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015955", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015955", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018177", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018177", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281275", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281275", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9B1", "url": "https://www.orthodb.org/?gene=Q5E9B1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43128", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43128", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43128:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43128:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00056", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00056", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02866", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02866", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-70268", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70268", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001303267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303267", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "23444", "url": "https://www.rhea-db.org/rhea/23444", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9B1", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9B1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATLKEKLIAPVAEEETRIPNNKITVVGVGQVGMACAISILGKSLTDELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDEEVAQLKKSADTLWGIQKDLKDL", "length": 334, "header": "sp|Q5E9B1-1|LDHB_BOVIN Isoform 1 of L-lactate dehydrogenase B chain OS=Bos taurus OX=9913 GN=LDHB PE=2 SV=4 CANONICAL=Q5E9B1-1" }, "isoforms": [ { "isoform_ac": "Q5E9B1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1/entry#Q5E9B1-1", "sequence": { "sequence": "MATLKEKLIAPVAEEETRIPNNKITVVGVGQVGMACAISILGKSLTDELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDEEVAQLKKSADTLWGIQKDLKDL", "length": 334, "header": "sp|Q5E9B1-1|LDHB_BOVIN Isoform 1 of L-lactate dehydrogenase B chain OS=Bos taurus OX=9913 GN=LDHB PE=2 SV=4 CANONICAL=Q5E9B1-1" }, "locus": { "chromosome": "5", "start_pos": 88562563, "end_pos": 88547375, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026118.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026118.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026118.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026118.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 240, "end_pos": 240, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B1", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1" } ], "site_lbl": "Tyr240" }, { "start_pos": 44, "end_pos": 44, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B1", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1" } ], "site_lbl": "Ser44" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B1", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:281275", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281275", "resource": "KEGG Pathway" }, { "id": "R-BTA-70268", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70268", "resource": "Reactome", "description": "Pyruvate metabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "O23569-1", "protein_name": "L-lactate dehydrogenase", "gene_name": "DL4665W", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEKNASTSSLKDLGPSGLDLTSAFFKPIHNSDPSLPSNRRTKVSVVGVGNVGMAIAQTILTQDLADEIALVDAKPDKLRGEMLDLQHAAAFLPRTKITASVDYEVTAGSDLCIVTAGARQNPGESRLNLLQRNVALFRHIIPPLAKASPDSILIIVSNPVDVLTYVAWKLSGFPVNRVLGSGTNLDSSRFRFLIADHLDVNAQDVQAFIVGEHGDSSVALWSSISVGGIPVLSFLEKNQIAYEKQTLEDIHQAVVGSAYEVIGLKGYTSWAIGYSVANLARTILRDQRKIHPVTVLARGFYGVDGGDVFLSLPALLGRNGVVAVTNVHMTDEEAEKLQKSAKTILEMQSQLGL", "length": 353 }, "evidence": [ { "id": "Q5E9B1", "url": "https://omabrowser.org/oma/group/Q5E9B1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P00336-1", "protein_name": "L-lactate dehydrogenase B chain", "gene_name": "LDHB", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATLKEKLIAPVAEEETTIPNNKITVVGVGQVGMACAISILGKSLTDELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGVHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVQGMYGIENEVFLSLPCVLNARGLTSVINQKLKDDEVAQLKNSADTLWGIQKDLKDL", "length": 334 }, "evidence": [ { "id": "Q5E9B1", "url": "https://omabrowser.org/oma/group/Q5E9B1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P16125-1", "protein_name": "L-lactate dehydrogenase B chain", "gene_name": "Ldhb", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATLKEKLIASVADDEAAVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCTIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVDSAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLRKSADTLWDIQKDLKDL", "length": 334 }, "evidence": [ { "id": "Q5E9B1", "url": "https://omabrowser.org/oma/group/Q5E9B1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P42123-1", "protein_name": "L-lactate dehydrogenase B chain", "gene_name": "Ldhb", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATLKEKLIAPVADDETAVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCTIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVDSAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLRKSADTLWDIQKDLKDL", "length": 334 }, "evidence": [ { "id": "Q5E9B1", "url": "https://omabrowser.org/oma/group/Q5E9B1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q95028-1", "protein_name": "L-lactate dehydrogenase", "gene_name": "Ldh", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAAIKDSLLAQVAEVLPSSGHKVTIVGIGQVGMASAFSILAQNVSKEVCLIDVCADKLQGELMDLQHGSNFLKNPQITASTDFAASANSRLCIVTAGVRQKEGESRLSLVQRNTDILKNIIPKLVEYSPDTILLMVSNPVDIMTYVAWKLSGLPKNRVIGSGTNLDSSRFRFLMSQRLGVAPTSCHGWIIGEHGDSSVPVWSGVNIAGVRLRELNPILGTGEDPEKWNELHKQVVDSAYEVIKLKGYTSWAIGLSTASLASAILRNTSSVAAVSTSVLGEHGIDKDVFLSLPCVLNANGVTSVVKQILTPTEVEQLQKSANIMSDVQAGLKF", "length": 332 }, "evidence": [ { "id": "Q5E9B1", "url": "https://omabrowser.org/oma/group/Q5E9B1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B1", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B1", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "L-lactate dehydrogenase (NAD+) activity", "id": "GO:0004459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004459", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B1", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "lactate metabolic process", "id": "GO:0006089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006089", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B1", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1" } ], "pmid": "" }, { "name": "pyruvate catabolic process", "id": "GO:0042867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042867", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B1", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 223, "end_pos": 225, "annotation": "n_glycosylation_sequon" }, { "start_pos": 267, "end_pos": 269, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "23444", "name": "", "equation": "(S)-lactate + NAD(+) = pyruvate + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BNS9-1", "Q3T056-1", "A0AAA9SB13-1", "P19858-1", "A0A3Q1LY19-1", "Q5E9B1-1", "A0A3Q1M4R3-1" ], "evidence": [ { "id": "23444", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23444" } ] }, { "id": "R-BTA-70510", "name": "LDH tetramer oxidises LACT to PYR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-29708" ], "output_participant_list": [], "enzyme_list": [ "P19858-1", "E1BNS9-1", "Q5E9B1-1" ], "evidence": [ { "id": "R-BTA-70510", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70510" } ] }, { "id": "R-BTA-71849", "name": "LDH tetramer reduces PYR to LACT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P19858-1", "E1BNS9-1", "Q5E9B1-1" ], "evidence": [ { "id": "R-BTA-71849", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71849" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-29708", "participant_name": "LACT [cytosol]", "crossref": [ { "id": "16651", "database": "ChEBI", "url": "" }, { "id": "C00186", "database": "KEGG Gene", "url": "" }, { "id": "5460161", "database": "PubChem Compound", "url": "" }, { "id": "79-33-4", "database": "CAS", "url": "" }, { "id": "L-LACTATE", "database": "AraCyc", "url": "" }, { "id": "ZINC000004658560", "database": "ZINC", "url": "" }, { "id": "C00186", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LY19", "gene_name": "", "activity": [ { "ec_number": "1.1.1.27", "activity": "(S)-lactate + NAD(+) = pyruvate + NADH + H(+).", "evidence": [ { "id": "A0A3Q1LY19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY19" } ] }, { "ec_number": "1.1.1.27", "activity": "", "evidence": [ { "id": "A0A3Q1LY19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY19" } ] } ] }, { "uniprot_ac": "A0A3Q1M4R3", "gene_name": "", "activity": [ { "ec_number": "1.1.1.27", "activity": "(S)-lactate + NAD(+) = pyruvate + NADH + H(+).", "evidence": [ { "id": "A0A3Q1M4R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4R3" } ] }, { "ec_number": "1.1.1.27", "activity": "", "evidence": [ { "id": "A0A3Q1M4R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4R3" } ] } ] }, { "uniprot_ac": "A0AAA9SB13", "gene_name": "LDHA", "activity": [ { "ec_number": "1.1.1.27", "activity": "(S)-lactate + NAD(+) = pyruvate + NADH + H(+).", "evidence": [ { "id": "A0AAA9SB13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB13" } ] }, { "ec_number": "1.1.1.27", "activity": "", "evidence": [ { "id": "A0AAA9SB13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB13" } ] } ] }, { "uniprot_ac": "E1BNS9", "gene_name": "LDHC", "activity": [ { "ec_number": "1.1.1.27", "activity": "(S)-lactate + NAD(+) = pyruvate + NADH + H(+).", "evidence": [ { "id": "E1BNS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS9" } ] }, { "ec_number": "1.1.1.27", "activity": "", "evidence": [ { "id": "E1BNS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS9" } ] } ] }, { "uniprot_ac": "P19858", "gene_name": "LDHA", "activity": [ { "ec_number": "1.1.1.27", "activity": "(S)-lactate + NAD(+) = pyruvate + NADH + H(+).", "evidence": [ { "id": "P19858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19858" } ] }, { "ec_number": "1.1.1.27", "activity": "", "evidence": [ { "id": "P19858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19858" } ] } ] }, { "uniprot_ac": "Q3T056", "gene_name": "LDHAL6B", "activity": [ { "ec_number": "1.1.1.27", "activity": "(S)-lactate + NAD(+) = pyruvate + NADH + H(+).", "evidence": [ { "id": "Q3T056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T056" } ] }, { "ec_number": "1.1.1.27", "activity": "", "evidence": [ { "id": "Q3T056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T056" } ] } ] }, { "uniprot_ac": "Q5E9B1", "gene_name": "LDHB", "activity": [ { "ec_number": "1.1.1.27", "activity": "(S)-lactate + NAD(+) = pyruvate + NADH + H(+).", "evidence": [ { "id": "Q5E9B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1" } ] }, { "ec_number": "1.1.1.27", "activity": "", "evidence": [ { "id": "Q5E9B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B1" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9B1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 334, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9B1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9B1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.1.1.27", "ec_name": "(S)-lactate + NAD(+) = pyruvate + NADH + H(+).", "evidence": [ { "id": "1.1.1.27", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.27" }, { "id": "1.1.1.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.1.1.27" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 44, 240 ], "sequon_annotation_sites": [ { "start_pos": 223, "end_pos": 225 }, { "start_pos": 267, "end_pos": 269 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9B3-1", "uniprot_ac": "Q5E9B3", "uniprot_id": "PGTB2_BOVIN", "mass": { "chemical_mass": 36972.0, "monoisotopic_mass": 36972.0 }, "refseq": { "ac": "NP_001015646", "name": "geranylgeranyl transferase type-2 subunit beta", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015646" }, "gene_names": [ { "name": "RABGGTB", "type": "recommended", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ] }, { "name": "RABGGTB", "type": "synonym", "evidence": [ { "id": "NP_001015646", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015646" } ] } ], "protein_names": [ { "name": "Geranylgeranyl transferase type-2 subunit beta", "type": "recommended", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3/entry#names_and_taxonomy" } ] }, { "name": "2.5.1.60", "type": "synonym", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3/entry#names_and_taxonomy" } ] }, { "name": "GGTase-II-beta", "type": "synonym", "evidence": [ { "id": "NP_001015646", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015646" }, { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3/entry#names_and_taxonomy" } ] }, { "name": "Geranylgeranyl transferase type II subunit beta", "type": "synonym", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3/entry#names_and_taxonomy" } ] }, { "name": "Rab GG transferase beta", "type": "synonym", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3/entry#names_and_taxonomy" } ] }, { "name": "Rab GGTase beta", "type": "synonym", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3/entry#names_and_taxonomy" } ] }, { "name": "Rab geranyl-geranyltransferase subunit beta", "type": "synonym", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3/entry#names_and_taxonomy" } ] }, { "name": "Rab geranylgeranyltransferase beta subunit", "type": "synonym", "evidence": [ { "id": "NP_001015646", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015646" } ] }, { "name": "Rab geranylgeranyltransferase subunit beta", "type": "synonym", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3/entry#names_and_taxonomy" } ] }, { "name": "Type II protein geranyl-geranyltransferase subunit beta", "type": "synonym", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3/entry#names_and_taxonomy" } ] }, { "name": "geranylgeranyl transferase type II subunit beta", "type": "synonym", "evidence": [ { "id": "NP_001015646", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015646" } ] }, { "name": "geranylgeranyl transferase type-2 subunit beta", "type": "synonym", "evidence": [ { "id": "NP_001015646", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015646" } ] }, { "name": "rab GG transferase beta", "type": "synonym", "evidence": [ { "id": "NP_001015646", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015646" } ] }, { "name": "rab GGTase beta", "type": "synonym", "evidence": [ { "id": "NP_001015646", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015646" } ] }, { "name": "rab geranyl-geranyltransferase subunit beta", "type": "synonym", "evidence": [ { "id": "NP_001015646", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015646" } ] }, { "name": "type II protein geranyl-geranyltransferase subunit beta", "type": "synonym", "evidence": [ { "id": "NP_001015646", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015646" } ] } ], "function": [ { "annotation": "Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A (By similarity). Catalytic subunit of the geranylgeranyl transferase type 3 (GGTase-3) complex (By similarity). The GGTase-3 complex geranylgeranylates and targets FBXL2 to the cellular membranes, where FBXL2 forms part of the E3 ubiquitin-protein ligase complex SCF(FBXL2) that mediates the degradation of membrane-anchored proteins (By similarity). The GGTase-3 complex geranylgeranylates Golgi v-SNARE protein YKT6 at 'Cys-194' and this prenylation is required for Golgi SNARE complex assembly (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B3", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3#function" }, { "database": "UniProtKB", "id": "P53611", "url": "https://www.uniprot.org/uniprotkb/P53611#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9B3", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RABGGTB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3", "locus": { "chromosome": "3", "start_pos": 69056998, "end_pos": 69065985, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018447", "url": "https://www.ensembl.org/id/ENSBTAG00000018447" } ] } } ], "crossref": [ { "id": "Q5E9B3", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9B3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018447", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018447", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02894", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02894", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533276", "url": "https://www.ncbi.nlm.nih.gov/gene/533276", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045089", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045089", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533276", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533276", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VKRCQCP", "url": "https://omabrowser.org/oma/group/VKRCQCP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9B3", "url": "https://www.orthodb.org/?gene=Q5E9B3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11774", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11774", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11774:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11774:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00432", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00432", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6803205", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6803205", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8873719", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8873719", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015646", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "21240", "url": "https://www.rhea-db.org/rhea/21240", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9B3", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9B3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQLHRMNREEILTFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSINVIDINKVVEYVQSLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRSFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVSPVFCMPEEVLRRVNVQPELVS", "length": 331, "header": "sp|Q5E9B3-1|PGTB2_BOVIN Isoform 1 of Geranylgeranyl transferase type-2 subunit beta OS=Bos taurus OX=9913 GN=RABGGTB PE=2 SV=1 CANONICAL=Q5E9B3-1" }, "isoforms": [ { "isoform_ac": "Q5E9B3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3/entry#Q5E9B3-1", "sequence": { "sequence": "MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQLHRMNREEILTFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSINVIDINKVVEYVQSLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRSFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVSPVFCMPEEVLRRVNVQPELVS", "length": 331, "header": "sp|Q5E9B3-1|PGTB2_BOVIN Isoform 1 of Geranylgeranyl transferase type-2 subunit beta OS=Bos taurus OX=9913 GN=RABGGTB PE=2 SV=1 CANONICAL=Q5E9B3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 3, "end_pos": 3, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B3", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ], "site_lbl": "Thr3" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B3", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:533276", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533276", "resource": "KEGG Pathway" }, { "id": "R-BTA-6803205", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6803205", "resource": "Reactome", "description": "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" }, { "id": "R-BTA-8873719", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8873719", "resource": "Reactome", "description": "RAB geranylgeranylation" } ], "orthologs": [ { "uniprot_canonical_ac": "B0G172-1", "protein_name": "Probable geranylgeranyl transferase type-2 subunit beta", "gene_name": "rabggtb", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTDNINKESTTTTTTIDHTTNLLIDKHVEYIVKLGSKKDSFEYWVTEHIRMNGMYWGLSSLYLLKSLDKLDKNEVIQWLLSCQKSNGGFGGNTSHDDHLLSTLSAVQILIQYDALDKIDINSVVDYVVKLQREDGSFVGDQWGEVDTRFSYAAIMCLSLLKSLDKINCEKAVEYILSCQNFDGGFGSIPGAESHAGQIFTCVGALSILNEINKIDIDKLGWWLSERQLPNGGLNGRPEKSSDVCYSWWVLSALSAIDRLHWIDNDKLKSYILKCQDNETGGIADKPGDIPDVFHTFFGICGLSLMGYFKDQIESIDPVYALGTKTLQKLGLNLPWNKNL", "length": 339 }, "evidence": [ { "id": "Q5E9B3", "url": "https://omabrowser.org/oma/group/Q5E9B3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "F1P4E5-1", "protein_name": "Geranylgeranyl transferase type-2 subunit beta", "gene_name": "RABGGTB", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGTPQKDVVIKPDAPSTLLSEKHADYIASYGTKKDDYEYCMSEYLRMSGVYWGLTAMDLMGQLHRMNKEEILAFIKSCQHECGGISASIGHDPHLLYTLSAVQILILYESLHVVDVNKIVEYVQSLQKEDGSFAGDKWGEIDTRFSFCAAATLALLGKLDAIDVGKAVEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITDQLHQINVDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKMIGRLHWIDREKLRCFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKAVNPVFCMPEDVLQRINVQPELVS", "length": 331 }, "evidence": [ { "id": "Q5E9B3", "url": "https://omabrowser.org/oma/group/Q5E9B3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3L5Z8-1", "protein_name": "MutS protein homolog 4", "gene_name": "MSH4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLRPESSPASLPVPGDSSLSVEVRPQVPRCSLGLQETPQSGPSAQAASVSSRPDTSGAAGDRSSSSSCPRAPSALPAQGSYCKSKRSYAENTFASDFTLGTSSSSARGSTCPQIVKTPLSAGNHQRSGYKSWTPQMEYSATSSSAVSAHSPSVVVAVVEGRGLARGEIGMASIDLKSPQIILSQFADNTTYAKVITKLKILSPLEIIMSNTACVVGNSTKLFTLITENFKNVNFTTIQRKYFNETKGLEYIEQLCTAEFSTVLMEVQSYYCLAAVAALLKYIEFIQNSLYAPKSLKICFQGSEQTAMIDSSSAQNLELLINNQDSRNNHTLFGVLNYTKTPGGSRRLRSNILEPLVDIETINMRLDCVQELLQDEELFFGLQSVIARFLDTEQLLSVLVQIPKQDTVNAAESKITNLIYLKHTLELVDPLKITLKNCNTPLLRAYYGSLEDKRFGIILDKIKTVINDDARYMKGCLNMRTQKCYAVRSNINEFLDIARRTYTEIVDDIAGMISQLAEKYSLPLRTSFSSARGFFIQMTTDCTALFNDKLPSEFIKISKVKNSYSFTSTDLIKMNERCQESLREIYHMTYMIVCKLLSEIYEHIHCLYKLSDTVSMLDMLLSFAHACTLSDYVRPEFTDTLAIKQGWHPILEKISVEKPVANNTYITEGSNFVIITGPNMSGKSTYLKQIALCQIMAQIGSYVPAEYSSFRIAEQIFTRISTDDDIETNSSTFMKEMKEIAYILHNANDKSLILIDELGRGTNTEEGIGICYAVCEYLLSLKAFTLFATHFLELCHIDVLYPNVENMYFEVQHVKNTSRNKEAILYTYKLSKGLTEEKNYGLKAAEASSLPPSIVLDAKEITTQITRQILQNQRSTPEMERQRAVYHLATRLVQTARNSQLDPDSLRTYLSNLKRKYEADFPRAEQVSGKTEE", "length": 932 }, "evidence": [ { "id": "Q5E9B3", "url": "https://omabrowser.org/oma/group/Q5E9B3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P20133-1", "protein_name": "Geranylgeranyl transferase type-2 subunit beta", "gene_name": "BET2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSGSLTLLKEKHIRYIESLDTKKHNFEYWLTEHLRLNGIYWGLTALCVLDSPETFVKEEVISFVLSCWDDKYGAFAPFPRHDAHLLTTLSAVQILATYDALDVLGKDRKVRLISFIRGNQLEDGSFQGDRFGEVDTRFVYTALSALSILGELTSEVVDPAVDFVLKCYNFDGGFGLCPNAESHAAQAFTCLGALAIANKLDMLSDDQLEEIGWWLCERQLPEGGLNGRPSKLPDVCYSWWVLSSLAIIGRLDWINYEKLTEFILKCQDEKKGGISDRPENEVDVFHTVFGVAGLSLMGYDNLVPIDPIYCMPKSVTSKFKKYPYK", "length": 325 }, "evidence": [ { "id": "Q5E9B3", "url": "https://omabrowser.org/oma/group/Q5E9B3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P53611-1", "protein_name": "Geranylgeranyl transferase type-2 subunit beta", "gene_name": "RABGGTB", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQLHRMNREEILAFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSINVIDVNKVVEYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRNFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVNPVFCMPEEVLQRVNVQPELVS", "length": 331 }, "evidence": [ { "id": "Q5E9B3", "url": "https://omabrowser.org/oma/group/Q5E9B3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q84J75-1", "protein_name": "Geranylgeranyl transferase type-2 subunit beta 1", "gene_name": "RGTB1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSSTSSSQMVQLVADKHVRYILMAEKKKESFESVVMDHLRMNGAYWGLTTLDLLDKLGCVSEEEVISWLMTCQHESGGFAGNTGHDPHILYTLSAVQILALFDKINILDIGKVSSYVAKLQNEDGSFSGDMWGEIDTRFSYIAICCLSILKCLDKINVEKAVKYIVSCKNLDGGFGCTPGAESHAGQIFCCVGALAITGSLHHVDKDSLGWWLCERQLKAGGLNGRPEKLADVCYSWWVLSSLIMIDRVHWIDKAKLVKFILDCQDLDNGGISDRPEDAVDIFHTYFGVAGLSLLEYPGVKVIDPAYALPVDVVNRIIFTK", "length": 321 }, "evidence": [ { "id": "Q5E9B3", "url": "https://omabrowser.org/oma/group/Q5E9B3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9XZ68-1", "protein_name": "Geranylgeranyl transferase type-2 subunit beta", "gene_name": "RabGGTb", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDFTTFVKPSNGGGDSGGGGDADGGGQKLQFWKHVEYIENHGKQEDDYEYCMTEFLRMSGIYWGTTALDIMGQLERLERKSIIEFVKRCQCPNTGGFAPCEGHDPHLLYTLSAIQILCTYDALEEIDREAVVRFVVGLQQPDGSFFGDKWGEVDTRFSFCAVASLTLLGRMEQTIDVEKAVKFVLSCCNQTDGGFGSKPGAESHAGLIYCCVGFFSLTHRLHLLDVDKLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLTIMGRLHWISSEKLQQFILSCQDTETGGFSDRTGNMPDIFHTLFGIGGLSLLGHSGLKAINPTLCMPQYIIDRLGIKPQLLPRP", "length": 347 }, "evidence": [ { "id": "Q5E9B3", "url": "https://omabrowser.org/oma/group/Q5E9B3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "Rab geranylgeranyltransferase activity", "id": "GO:0004663", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004663", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B3", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B3", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B3", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B3", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ], "pmid": "" }, { "name": "protein geranylgeranylation", "id": "GO:0018344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018344", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B3", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Rab-protein geranylgeranyltransferase complex", "id": "GO:0005968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005968", "evidence": [ { "database": "UniProtKB", "id": "Q5E9B3", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21240", "name": "", "equation": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5EA80-1", "A0AAF6Z5M1-1", "Q5EAD5-1", "P29702-1", "Q5E9B3-1", "A0AAA9SWU6-1", "A0AAA9S4G1-1" ], "evidence": [ { "id": "21240", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21240" } ] }, { "id": "R-BTA-6801101", "name": "RABGGTA binds RABGGTB", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9B3-1", "Q5EA80-1" ], "evidence": [ { "id": "R-BTA-6801101", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6801101" } ] }, { "id": "R-BTA-6801109", "name": "CHM binds RGGT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9B3-1", "Q5EA80-1" ], "evidence": [ { "id": "R-BTA-6801109", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6801109" } ] }, { "id": "R-BTA-8870457", "name": "FarC-PTP4A2 binds RABGGTB", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9B3-1" ], "evidence": [ { "id": "R-BTA-8870457", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8870457" } ] }, { "id": "R-BTA-8870461", "name": "RABGGTA and RABGGTB bind", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9B3-1", "Q5EA80-1" ], "evidence": [ { "id": "R-BTA-8870461", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8870461" } ] }, { "id": "R-BTA-8870465", "name": "RGGT binds the RAB-binding subunit", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9B3-1", "Q5EA80-1" ], "evidence": [ { "id": "R-BTA-8870465", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8870465" } ] }, { "id": "R-BTA-8870466", "name": "RGGT:CHM binds RABs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0IIG7-1", "Q8HZJ5-1", "A0A140T898-1", "F1MNI4-1", "Q3MHP2-1", "A0A3S5ZPA2-1", "A6QR46-1", "Q3ZC27-1", "A0AAA9TS74-1", "A0AAA9SV95-1", "A0A3Q1MGR4-1", "P10948-1", "Q2TBH7-1", "F1N2J9-1", "P10949-1", "P11023-1", "Q17R06-1", "A0A3Q1MWA3-1", "F1N7V2-1", "A4FV54-1", "F2Z4D5-1", "Q58DW6-1", "Q17QB7-1", "Q17QU4-1", "Q1RMR4-1", "Q5E9B3-1", "Q5EA80-1", "E1BJA0-1" ], "evidence": [ { "id": "R-BTA-8870466", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8870466" } ] }, { "id": "R-BTA-8870469", "name": "RGGT geranylgeranylates RAB proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-1131164" ], "output_participant_list": [], "enzyme_list": [ "Q0IIG7-1", "Q8HZJ5-1", "A0A140T898-1", "F1MNI4-1", "Q3MHP2-1", "A0A3S5ZPA2-1", "A6QR46-1", "Q3ZC27-1", "A0AAA9TS74-1", "A0AAA9SV95-1", "A0A3Q1MGR4-1", "P10948-1", "Q2TBH7-1", "F1N2J9-1", "P10949-1", "P11023-1", "Q17R06-1", "A0A3Q1MWA3-1", "F1N7V2-1", "A4FV54-1", "F2Z4D5-1", "Q58DW6-1", "Q17QB7-1", "Q17QU4-1", "Q1RMR4-1", "Q5E9B3-1", "Q5EA80-1", "E1BJA0-1" ], "evidence": [ { "id": "R-BTA-8870469", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8870469" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1131164", "participant_name": "geranylgeranyl diphosphate [cytosol]", "crossref": [ { "id": "48861", "database": "ChEBI", "url": "" }, { "id": "C00353", "database": "COMPOUND", "url": "" }, { "id": "3052", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "ZINC000012495043", "database": "ZINC", "url": "" }, { "id": "HMDB0004486", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1MWA3", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MWA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWA3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MWA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWA3" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S4G1", "gene_name": "FNTA", "activity": [ { "ec_number": "2.5.1.58", "activity": "L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] }, { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] }, { "ec_number": "2.5.1.58", "activity": "", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SWU6", "gene_name": "PGGT1B", "activity": [ { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAA9SWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "A0AAA9SWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6" } ] } ] }, { "uniprot_ac": "A0AAA9TS74", "gene_name": "RAB36", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9TS74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS74" } ] } ] }, { "uniprot_ac": "A0AAF6Z5M1", "gene_name": "RABGGTB", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAF6Z5M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "A0AAF6Z5M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1" } ] } ] }, { "uniprot_ac": "A4FV54", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A4FV54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FV54" } ] } ] }, { "uniprot_ac": "A6QR46", "gene_name": "RAB6B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6QR46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR46" } ] } ] }, { "uniprot_ac": "E1BJA0", "gene_name": "RAB33A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] } ] }, { "uniprot_ac": "F1MNI4", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] } ] }, { "uniprot_ac": "F1N2J9", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] } ] }, { "uniprot_ac": "F1N7V2", "gene_name": "RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "P10948", "gene_name": "RAB3B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10948" } ] } ] }, { "uniprot_ac": "P10949", "gene_name": "RAB3C", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10949" } ] } ] }, { "uniprot_ac": "P11023", "gene_name": "RAB3A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P11023", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11023" } ] } ] }, { "uniprot_ac": "P29702", "gene_name": "FNTA", "activity": [ { "ec_number": "2.5.1.58", "activity": "L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "P29702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29702" } ] }, { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "P29702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29702" } ] }, { "ec_number": "2.5.1.58", "activity": "", "evidence": [ { "id": "P29702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29702" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "P29702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29702" } ] } ] }, { "uniprot_ac": "Q0IIG7", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] } ] }, { "uniprot_ac": "Q17QB7", "gene_name": "RAB30", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] } ] }, { "uniprot_ac": "Q17QU4", "gene_name": "RAB39B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] } ] }, { "uniprot_ac": "Q17R06", "gene_name": "RAB21", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] } ] }, { "uniprot_ac": "Q1RMR4", "gene_name": "RAB15", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q1RMR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMR4" } ] } ] }, { "uniprot_ac": "Q2TBH7", "gene_name": "RAB4A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2TBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBH7" } ] } ] }, { "uniprot_ac": "Q3MHP2", "gene_name": "RAB11B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3MHP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP2" } ] } ] }, { "uniprot_ac": "Q3ZC27", "gene_name": "RAB19", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q3ZC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC27" } ] } ] }, { "uniprot_ac": "Q58DW6", "gene_name": "RAB25", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q58DW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DW6" } ] } ] }, { "uniprot_ac": "Q5E9B3", "gene_name": "RABGGTB", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ] } ] }, { "uniprot_ac": "Q5EA80", "gene_name": "RABGGTA", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ] } ] }, { "uniprot_ac": "Q5EAD5", "gene_name": "PGGT1B", "activity": [ { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "Q5EAD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": 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"crossref": [ { "id": "Q5E9E8", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9E8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012758", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012758", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "521829", "url": "https://www.ncbi.nlm.nih.gov/gene/521829", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045231", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045231", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521829", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521829", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HIRAKSM", "url": "https://omabrowser.org/oma/group/HIRAKSM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9E8", "url": "https://www.orthodb.org/?gene=Q5E9E8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21236", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21236", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21236:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21236:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04893", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04893", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029715", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9E8", "url": "https://www.uniprot.org/uniprotkb/Q5E9E8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9E8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9E8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGFDNLNTDFYQTSYSIDDQSQQSYDYGGSGGPYSKQYAGYDYSHQGRFVPADMMQPQQPYTGQIFQPTQTYTPTTPQPFYGNNFEDEPPLLEELGINFDHIWQKTLTVLHPLKVADGSIMNETDLAGPMVFCLAFGATLLLAGKIQFGYVYGISAIGCLGMFCLLNLMSMTGVSFGCVASVLGYCLLPMILLSSFAVIFSLQGMVGIILTAGIIGWCSFSASKIFISALAMEGQQLLVAYPCALLYGVFALISVF", "length": 257, "header": "sp|Q5E9E8-1|YIPF5_BOVIN Isoform 1 of Protein YIPF5 OS=Bos taurus OX=9913 GN=YIPF5 PE=2 SV=1 CANONICAL=Q5E9E8-1" }, "isoforms": [ { "isoform_ac": "Q5E9E8-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9E8/entry#Q5E9E8-1", "sequence": { "sequence": "MSGFDNLNTDFYQTSYSIDDQSQQSYDYGGSGGPYSKQYAGYDYSHQGRFVPADMMQPQQPYTGQIFQPTQTYTPTTPQPFYGNNFEDEPPLLEELGINFDHIWQKTLTVLHPLKVADGSIMNETDLAGPMVFCLAFGATLLLAGKIQFGYVYGISAIGCLGMFCLLNLMSMTGVSFGCVASVLGYCLLPMILLSSFAVIFSLQGMVGIILTAGIIGWCSFSASKIFISALAMEGQQLLVAYPCALLYGVFALISVF", "length": 257, "header": "sp|Q5E9E8-1|YIPF5_BOVIN Isoform 1 of Protein YIPF5 OS=Bos taurus OX=9913 GN=YIPF5 PE=2 SV=1 CANONICAL=Q5E9E8-1" }, "locus": { "chromosome": "7", "start_pos": 55274592, "end_pos": 55260358, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016956.4", "url": "https://www.ensembl.org/id/ENSBTAT00000016956.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016956.3", "url": "https://www.ensembl.org/id/ENSBTAP00000016956.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9E8", "url": "https://www.uniprot.org/uniprotkb/Q5E9E8" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:521829", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521829", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E1C6B9-1", "protein_name": "Protein YIPF", "gene_name": "YIPF5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGFDSFNTDFFQTSYSIDEQAQPYEYGGGRPYSRQYGGYEYSQQSGFVPPEMMQQQPYTGQIYQPTQTYTPTSAQSFYGSNFEDEPPLLEELGINFDHIWQKTLTVLHPLKVADGSIMNETDLAGPMVFCLAFGATLLLAGKIQFGYVYGISAIGCLGMFCLLNLMSMTGVSFGCVASVLGYCLLPMILLSTFAIVFSLQGVMGIILTAGIIGWCSFSASKIFISALAMEGQQLLVAYPCALLYGVFALISVF", "length": 254 }, "evidence": [ { "id": "Q5E9E8", "url": "https://omabrowser.org/oma/group/Q5E9E8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P53039-1", "protein_name": "Protein transport protein YIP1", "gene_name": "YIP1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": 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"https://www.ebi.ac.uk/interpro/entry/IPR039865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041534", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041534", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533147", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533147", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HKFWAYE", "url": "https://omabrowser.org/oma/group/HKFWAYE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9G1", "url": "https://www.orthodb.org/?gene=Q5E9G1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12085", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12085", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12085:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12085:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17958", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17958", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015645", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9G1", "url": "https://www.uniprot.org/uniprotkb/Q5E9G1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9G1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9G1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDWKEILRRRLATPSTSPHKKKSEQELKDEEMDLFTKYYSEWKGGRKNTNEFYKTIPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGPKCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENREALVANDNENSTDLDDT", "length": 453, "header": "sp|Q5E9G1-1|P2R3C_BOVIN Isoform 1 of Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma OS=Bos taurus OX=9913 GN=PPP2R3C PE=2 SV=1 CANONICAL=Q5E9G1-1" }, "isoforms": [ { "isoform_ac": "Q5E9G1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9G1/entry#Q5E9G1-1", "sequence": { "sequence": "MDWKEILRRRLATPSTSPHKKKSEQELKDEEMDLFTKYYSEWKGGRKNTNEFYKTIPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGPKCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENREALVANDNENSTDLDDT", "length": 453, "header": "sp|Q5E9G1-1|P2R3C_BOVIN Isoform 1 of Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma OS=Bos taurus OX=9913 GN=PPP2R3C PE=2 SV=1 CANONICAL=Q5E9G1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G1", "url": "https://www.uniprot.org/uniprotkb/Q5E9G1" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:533147", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533147", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A1B6-1", "protein_name": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma", "gene_name": "PPP2R3C", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDWKEILRRRLAMPNTGPNKKKTEQELKDEEMDLFTKYYSEWKGDRKNTNEFYKTIPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGPKCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENREALVANDNENSTDLDDT", "length": 453 }, "evidence": [ { "id": "Q5E9G1", "url": "https://omabrowser.org/oma/group/Q5E9G1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6AXZ3-1", "protein_name": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma", "gene_name": "Ppp2r3c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDWKDVLRRRLASPNSDPKRKKSEQELKDEEMDLFTKYYSEWKGGRKNTNEFYKTIPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQIPPMIGEEAMINYENFLKVGEKAGPKCKQFFTAKVFAKLLHTDSYGRVSIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENREALVANDNENSADLDDT", "length": 453 }, "evidence": [ { "id": "Q5E9G1", "url": "https://omabrowser.org/oma/group/Q5E9G1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q969Q6-1", "protein_name": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma", "gene_name": "PPP2R3C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDWKEVLRRRLATPNTCPNKKKSEQELKDEEMDLFTKYYSEWKGGRKNTNEFYKTIPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGAKCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENREALVANDSENSADLDDT", "length": 453 }, "evidence": [ { "id": "Q5E9G1", "url": "https://omabrowser.org/oma/group/Q5E9G1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9FEE2-1", "protein_name": "Probable serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit TON2", "gene_name": "TON2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MYSGSSDGESHDTSTQRKIPPASSMLWVRNLRRYIGSGAGLGSEALMELETKRILLEIFKEKQQKSQEAGTIPSFYKKKPEEGSISQRVQKLAKYRFLKKQSDLLLNADDLAAMWVCLRENCVIDDATGAEKMNYEDFCHIASVCTEQIGPKCRRFFSPSNFMKFEKDEAGRIAILPFYLYVMRTVSLTQARIDMSELDEDSDGFLHSDEMESYIGGLIPNLAQLRDMPPAFNQMYCRIASQKFFFFCDPHRRGRACIKKILLSNCLQELMELHQESEEEVTDTEQAENWFSLTSAQRICDMFLALDKDMSGSLCKQELKEYADGTLTEIFIERVFDEHVRRGKIVAGNSREMDFDSFLDFVLALENKDTPEGLTYLFRCLDLQGRGFLTTADIHSLFRDVHQKWIEGGNYELCIEDVRDEIWDMVKPSDPLKITLGDLLGCKQGGTVASMLIDVRGFWAHDNRENLLQEEEEPPEEESQ", "length": 480 }, "evidence": [ { "id": "Q5E9G1", "url": "https://omabrowser.org/oma/group/Q5E9G1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9JK24-1", "protein_name": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma", "gene_name": "Ppp2r3c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDWKDVLRRRLASPNTDPKRKKSEQELKDEEMDLFTKYYSEWKGGRKNTNEFYKTIPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQIPPMIGEEAMINYENFLKVGEKAGPKCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENREALVANDNENSADLDDT", "length": 453 }, "evidence": [ { "id": "Q5E9G1", "url": "https://omabrowser.org/oma/group/Q5E9G1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "regulation of dephosphorylation", "id": "GO:0035303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035303", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G1", "url": "https://www.uniprot.org/uniprotkb/Q5E9G1" } ], "pmid": "" }, { "name": "microtubule 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organization", "id": "GO:0030865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030865", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G1", "url": "https://www.uniprot.org/uniprotkb/Q5E9G1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G1", "url": "https://www.uniprot.org/uniprotkb/Q5E9G1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G1", "url": "https://www.uniprot.org/uniprotkb/Q5E9G1" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "Q5E9G1", "url": "https://www.uniprot.org/uniprotkb/Q5E9G1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, 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Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production. Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H0", "url": "https://www.uniprot.org/uniprotkb/Q5E9H0#function" }, { "database": "UniProtKB", "id": "Q53H76", "url": "https://www.uniprot.org/uniprotkb/Q53H76#function" }, { "database": "UniProtKB", "id": "P97535", "url": "https://www.uniprot.org/uniprotkb/P97535#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9H0", "url": "https://www.uniprot.org/uniprotkb/Q5E9H0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLA1A", "url": "https://www.uniprot.org/uniprotkb/Q5E9H0", "locus": {} } ], "crossref": [ { "id": "Q5E9H0", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9H0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00707", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00707", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515900", "url": "https://www.ncbi.nlm.nih.gov/gene/515900", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013818", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013818", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016272", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016272", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033906", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033906", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515900", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515900", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9H0", "url": "https://www.orthodb.org/?gene=Q5E9H0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11610", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11610", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11610:SF111", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11610:SF111", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00151", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00151", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015610", "url": 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"sequence": "MPPDFWERCFWLWGLLLWLSVGSTGDAPPTPQTNCTDFQNANLLRGTNLKVQFLLFTPLDPSCGQLVEESSDIQNSGFNATLGTKLVIHGFRALGTKPSWIDRFIDALLRAADANVIAVDWVYGSTAAYFSAVENVIKLGLEISRFLRKLLALGVSESSIHIIGISLGAHVGGMVGHFYNGQLGQITGLDPAGPEYTRASLEERLDPGDALFVEAIHTDTDNLGIRIPVGHVDYFINGGQDQPGCPTSIYAGYSYLICDHMRAVHLYISALENSCPLVAFPCTNYKDFLAGQCLDCFNPFLLSCPRIGLVEQGGVKIEPLPKEVKVYLLTTSMAPYCVHHSLVEFHLQEPRNKDTCITVTFLSSSVTSSVKITIPRHQRVGKGVLAHPSPQCQINQVKLKLQASHRVWKKDQTTIIGRFCTAPLPVNDNKKMVCLPEPVNLQASETVSHDLKITCI", "length": 456, "header": "sp|Q5E9H0-1|PLA1A_BOVIN Isoform 1 of Phospholipase A1 member A OS=Bos taurus OX=9913 GN=PLA1A PE=2 SV=1 CANONICAL=Q5E9H0-1" }, "isoforms": [ { "isoform_ac": "Q5E9H0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9H0/entry#Q5E9H0-1", "sequence": { "sequence": "MPPDFWERCFWLWGLLLWLSVGSTGDAPPTPQTNCTDFQNANLLRGTNLKVQFLLFTPLDPSCGQLVEESSDIQNSGFNATLGTKLVIHGFRALGTKPSWIDRFIDALLRAADANVIAVDWVYGSTAAYFSAVENVIKLGLEISRFLRKLLALGVSESSIHIIGISLGAHVGGMVGHFYNGQLGQITGLDPAGPEYTRASLEERLDPGDALFVEAIHTDTDNLGIRIPVGHVDYFINGGQDQPGCPTSIYAGYSYLICDHMRAVHLYISALENSCPLVAFPCTNYKDFLAGQCLDCFNPFLLSCPRIGLVEQGGVKIEPLPKEVKVYLLTTSMAPYCVHHSLVEFHLQEPRNKDTCITVTFLSSSVTSSVKITIPRHQRVGKGVLAHPSPQCQINQVKLKLQASHRVWKKDQTTIIGRFCTAPLPVNDNKKMVCLPEPVNLQASETVSHDLKITCI", "length": 456, "header": "sp|Q5E9H0-1|PLA1A_BOVIN Isoform 1 of Phospholipase A1 member A OS=Bos taurus OX=9913 GN=PLA1A PE=2 SV=1 CANONICAL=Q5E9H0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 30, "start_aa": "Thr", "end_pos": 30, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr30", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 34, "start_aa": "Asn", "end_pos": 34, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn34", "evidence": [ { "id": "Q5E9H0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H0#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H0", "url": "https://www.uniprot.org/uniprotkb/Q5E9H0" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:515900", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515900", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H0", "url": "https://www.uniprot.org/uniprotkb/Q5E9H0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H0", "url": "https://www.uniprot.org/uniprotkb/Q5E9H0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phospholipase A1 activity", "id": "GO:0008970", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008970", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H0", "url": "https://www.uniprot.org/uniprotkb/Q5E9H0" } ], "pmid": "" }, { "name": "phosphatidylserine lysophospholipase activity", "id": "GO:0120560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120560", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H0", "url": "https://www.uniprot.org/uniprotkb/Q5E9H0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" }, { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "32979", "name": "", "equation": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q32KR8-1", "Q5E9H0-1", "Q08DW9-1" ], "evidence": [ { "id": "32979", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/32979" } ] }, { "id": "40491", "name": "", "equation": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + (9Z)-octadecenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q32KR8-1", "Q5E9H0-1" ], "evidence": [ { "id": "40491", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40491" } ] }, { "id": "40499", "name": "", "equation": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = sn-glycero-3-phospho-L-serine + (9Z)-octadecenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3SZ79-1", "Q08DW9-1", "Q32KR8-1", "Q5E9H0-1" ], "evidence": [ { "id": "40499", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40499" } ] }, { "id": "41187", "name": "", "equation": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + hexadecanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q32KR8-1", "Q5E9H0-1" ], "evidence": [ { "id": "41187", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41187" } ] }, { "id": "42212", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O46606-1", "Q32KR8-1", "Q5E9H0-1" ], "evidence": [ { "id": "42212", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42212" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "O46606", "gene_name": "DDHD1", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O46606", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46606" } ] }, { "ec_number": "3.1.1.111", "activity": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = sn-glycero-3-phospho-L-serine + a fatty acid + H(+).", "evidence": [ { "id": "O46606", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46606" } ] }, { "ec_number": "3.1.1.118", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+).", "evidence": [ { "id": "O46606", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46606" } ] }, { "ec_number": "3.1.1.111", "activity": "", "evidence": [ { "id": "O46606", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46606" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "O46606", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46606" } ] } ] }, { "uniprot_ac": "Q08DW9", "gene_name": "ABHD12", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q08DW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DW9" } ] }, { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q08DW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DW9" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q08DW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DW9" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q08DW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DW9" } ] } ] }, { "uniprot_ac": "Q32KR8", "gene_name": "ADPRH", "activity": [ { "ec_number": "3.2.2.19", "activity": "N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + H2O = ADP-D-ribose + L-arginyl-[protein].", "evidence": [ { "id": "Q32KR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KR8" } ] }, { "ec_number": "3.2.2.19", "activity": "", "evidence": [ { "id": "Q32KR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KR8" } ] }, { "ec_number": "3.1.1.111", "activity": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = sn-glycero-3-phospho-L-serine + a fatty acid + H(+).", "evidence": [ { "id": "Q32KR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KR8" } ] }, { "ec_number": "3.1.1.111", "activity": "", "evidence": [ { "id": "Q32KR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KR8" } ] } ] }, { "uniprot_ac": "Q3SZ79", "gene_name": "LIPC", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q3SZ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ79" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q3SZ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ79" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q3SZ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ79" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q3SZ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ79" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q3SZ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ79" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q3SZ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ79" } ] } ] }, { "uniprot_ac": "Q5E9H0", "gene_name": "PLA1A", "activity": [ { "ec_number": "3.1.1.111", "activity": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = sn-glycero-3-phospho-L-serine + a fatty acid + H(+).", "evidence": [ { "id": "Q5E9H0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H0" } ] }, { "ec_number": "3.1.1.111", "activity": "", "evidence": [ { "id": "Q5E9H0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9H0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 456, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9H0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9H0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.1.111", "ec_name": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = sn-glycero-3-phospho-L-serine + a fatty acid + H(+).", "evidence": [ { "id": "3.1.1.111", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111" }, { "id": "3.1.1.111", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.111" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 34 ], "o_linked_sites": [ 30 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 34, "end_pos": 36 }, { "start_pos": 79, "end_pos": 81 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", 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"total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9H5-1", "uniprot_ac": "Q5E9H5", "uniprot_id": "BCS1_BOVIN", "mass": { "chemical_mass": 47504.0, "monoisotopic_mass": 47504.0 }, "refseq": { "ac": "NP_001015671", "name": "mitochondrial chaperone BCS1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015671" }, "gene_names": [ { "name": "BCS1L", "type": "recommended", "evidence": [ { "id": "Q5E9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ] }, { "name": "BCS1L", "type": "synonym", "evidence": [ { "id": "NP_001015671", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015671" } ] } ], "protein_names": [ { "name": "Mitochondrial chaperone BCS1", "type": "recommended", "evidence": [ { "id": "Q5E9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5/entry#names_and_taxonomy" } ] }, { "name": "3.6.1.-", "type": "synonym", "evidence": [ { "id": "Q5E9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5/entry#names_and_taxonomy" } ] }, { "name": "BCS1-like protein", "type": "synonym", "evidence": [ { "id": "NP_001015671", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015671" }, { "id": "Q5E9H5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial chaperone BCS1", "type": "synonym", "evidence": [ { "id": "NP_001015671", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015671" } ] } ], "function": [ { "annotation": "Chaperone necessary for the incorporation of Rieske iron-sulfur protein UQCRFS1 into the mitochondrial respiratory chain complex III (By similarity). Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H5", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5#function" }, { "database": "UniProtKB", "id": "Q9Y276", "url": "https://www.uniprot.org/uniprotkb/Q9Y276#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9H5", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BCS1L", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5", "locus": { "chromosome": "2", "start_pos": 106623100, "end_pos": 106619142, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003813", "url": "https://www.ensembl.org/id/ENSBTAG00000003813" } ] } } ], "crossref": [ { "id": "Q5E9H5", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9H5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003813", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003813", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19510", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19510", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539713", "url": "https://www.ncbi.nlm.nih.gov/gene/539713", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003959", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003959", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014851", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050747", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050747", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057495", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057495", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539713", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539713", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WMTLYQR", "url": "https://omabrowser.org/oma/group/WMTLYQR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9H5", "url": "https://www.orthodb.org/?gene=Q5E9H5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23070", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23070", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00004", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00004", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08740", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08740", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25426", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25426", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015671", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9H5", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9H5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLSDFVLALKDNPYFGAGFGLVGVGTALALARKGAQLGLVAFRRHYMITLEVPARDRSYAWLLSWLTRHSTRTQHLSVETTYLQHESGRISTKFEFVPSPGNHFIWYQGKWIRVERSREMQMIDLQTGTPWESVTFTALGTDRKVFFNILEEARELALQQEEGKTVMYTAVGSEWRPFGYPRRRRPLNSVVLEQGVTERIVRDIREFIDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELQHSICLLSLTDSSLSDDRLNHLLSVAPQQSLVLLEDVDAAFLSRDLAAENPIKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDMKEYVGHCSRWQLTQMFQRFYPGQATSLAENFADRVLQATTQISPAQVQGYFMLYKNDPAGAIQNAESLRR", "length": 419, "header": "sp|Q5E9H5-1|BCS1_BOVIN Isoform 1 of Mitochondrial chaperone BCS1 OS=Bos taurus OX=9913 GN=BCS1L PE=2 SV=1 CANONICAL=Q5E9H5-1" }, "isoforms": [ { "isoform_ac": "Q5E9H5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5/entry#Q5E9H5-1", "sequence": { "sequence": "MPLSDFVLALKDNPYFGAGFGLVGVGTALALARKGAQLGLVAFRRHYMITLEVPARDRSYAWLLSWLTRHSTRTQHLSVETTYLQHESGRISTKFEFVPSPGNHFIWYQGKWIRVERSREMQMIDLQTGTPWESVTFTALGTDRKVFFNILEEARELALQQEEGKTVMYTAVGSEWRPFGYPRRRRPLNSVVLEQGVTERIVRDIREFIDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELQHSICLLSLTDSSLSDDRLNHLLSVAPQQSLVLLEDVDAAFLSRDLAAENPIKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDMKEYVGHCSRWQLTQMFQRFYPGQATSLAENFADRVLQATTQISPAQVQGYFMLYKNDPAGAIQNAESLRR", "length": 419, "header": "sp|Q5E9H5-1|BCS1_BOVIN Isoform 1 of Mitochondrial chaperone BCS1 OS=Bos taurus OX=9913 GN=BCS1L PE=2 SV=1 CANONICAL=Q5E9H5-1" }, "locus": { "chromosome": "2", "start_pos": 106623041, "end_pos": 106620657, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004967.3", "url": "https://www.ensembl.org/id/ENSBTAT00000004967.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004967.1", "url": "https://www.ensembl.org/id/ENSBTAP00000004967.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 181, "end_pos": 181, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H5", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ], "site_lbl": "Tyr181" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H5", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:539713", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539713", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AKM3-1", "protein_name": "Mitochondrial chaperone BCS1", "gene_name": "BCS1L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPFSDFVLALKDNPYFGAGFGLVGVGTALALARKGAQLGLVAFRRHYMITLEVPARDRSYAWLLSWLTRHSARTQHLSVETSYLQHESGRISTKFEFVPSPGNHFIWYQGKWIRVERSREMQMIDLQTGTPWESVTFTALGTDRKIFFNILEEARELALQQEEGKTVMYTAVGSEWRPFGYPRRRRPLNSVVLEQGLADRIVRDIREFIDNPKWYTDRGIPYRRGYLLYGPPGCGKSSFITALAGELQHSICLLSLTDSSLSDDRLNHLLSVAPQQSLVLLEDVDAAFLSRDLAAENPVKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNHVDRLDPALIRPGRVDLKEYVGHCSRWQLTQMFQRFYPGQAPSLAESFADRALQATTQISPAQVQGYFMLYKNDPEGAVRHADSLRR", "length": 419 }, "evidence": [ { "id": "Q5E9H5", "url": "https://omabrowser.org/oma/group/Q5E9H5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MWR2-1", "protein_name": "Mitochondrial chaperone BCS1", "gene_name": "LOC100771607", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPFTDFVLALKDNPYFGAGFGLVGVGTVLAAARKGAQLGLVAFRRHYMITLEVPARDRSYAWLLSWLTRHSTRTQHLSVETSYLQHESGRISTKFEFIPSPGNHFIWYQGKWIRVQRNRDMQMVDLQTGTPWESVIFTALGTDRKVFFNILEEARALALQQEEGKTVMYTAVGSEWRTFGYPRRRRPLDSVVLQQGLADRIVKDIREFIDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGEVEHSICLLSLTDSSLSDDRLNHLLSVAPQQSLVLLEDVDAAFLSRDLAVENPVKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDMKEYVGYCSHWQLTQMFKRFYPGQAPSLAENFAEHVLKATSQISPAQVQGYFMLYKNDPMGAVDNVESLR", "length": 418 }, "evidence": [ { "id": "Q5E9H5", "url": "https://omabrowser.org/oma/group/Q5E9H5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P32839-1", "protein_name": "Mitochondrial chaperone BCS1", "gene_name": "BCS1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSDKPIDIQYDKQATPNLSGVITPPTNETGNDSVREKLSKLVGDAMSNNPYFAAGGGLMILGTGLAVARSGIIKASRVLYRQMIVDLEIQSKDKSYAWFLTWMAKHPQRVSRHLSVRTNYIQHDNGSVSTKFSLVPGPGNHWIRYKGAFILIKRERSAKMIDIANGSPFETVTLTTLYRDKHLFDDILNEAKDIALKTTEGKTVIYTSFGPEWRKFGQPKAKRMLPSVILDSGIKEGILDDVYDFMKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSENNLTDDRLNHLMNNMPERSILLLEDIDAAFNKRSQTGEQGFHSSVTFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKVFVGNATPYQVEKMFMKFYPGETDICKKFVNSVKELDITVSTAQLQGLFVMNKDAPHDALKMVSSLRNANHIF", "length": 456 }, "evidence": [ { "id": "Q5E9H5", "url": "https://omabrowser.org/oma/group/Q5E9H5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54DY9-1", "protein_name": "Probable mitochondrial chaperone BCS1-B", "gene_name": "bcsl1b", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MENVITNNNKGLPKSILKFIPEPIQPLFENPFFSAGFGLIGVGSILAMGRKGFQQAMIQSRRYFFVSVEVPSKDKSFHWLMEWLATKKNKNTRHVSVETTFHQHESGDIVSRINFVPSVGTHYVFYRGRVIKVERSREKNVIDMNSGNLWESITLTTLGTGRQVFQNLIEEAKEMALEKEEGKTLIYTSMGTDWRRFGHPRRKRPISSVILDKGKSELIIQDVKKFLNNSDWYNDRGIPYRRGYLLYGPPGTGKSSFITALAGELQLSICILNLAGKSVSDTSLNQLLATAPQRSIILLEDIDSAIQTGNHDLSAKSNSANAPSISSGGLQYQGYYGNPSVSSGGSALTFSGLLNALDGVAASEGRILFMTTNHLEKLDKVLIRPGRVDLQIEIGLCSSYQMEQMFLKFYPTDFDLAKQFVEKLENYKFSPAQLQAYFMTYSNNSIEAINNLNELIKK", "length": 458 }, "evidence": [ { "id": "Q5E9H5", "url": "https://omabrowser.org/oma/group/Q5E9H5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q7ZV60-1", "protein_name": "Mitochondrial chaperone BCS1", "gene_name": "bcs1l", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTLSDFIGALKDNPYFGAGFGLVGVGTALAVARKGAQVGMIFFRRHYMITLEVPSKDKSYHWLLSWITKHAKHTQHLSVETSYMQHESGKVHTQFDFHPSPGNHIIWYGRKWIRVERVREKQMMDLHTGTPWESVTFTALGRDRQTFFNILQEARELALKQEEGRTVMYTAMGAEWRPFGFPRRRRPLSSVVLESGVAERIVDDVKEFIGNPKWYTDRGIPYRRGYLLYGPPGCGKSSFITALAGELGYSICLMSLSDRSLSDDRLNHLLSVAPQQSIILLEDVDAAFVSRELLPTENPLAYQGMGRLTFSGLLNALDGVASSEARIVFMTTNFIERLDPALVRPGRVDLKQYVGHCSHWQLTQMFRRFYPQESAAEADHFSEQALAAHTDLSAAQVQGHFMLYKTDPAGAIKNIAEIKD", "length": 420 }, "evidence": [ { "id": "Q5E9H5", "url": "https://omabrowser.org/oma/group/Q5E9H5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9CZP5-1", "protein_name": "Mitochondrial chaperone BCS1", "gene_name": "Bcs1l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPFSDFVLALKDNPYFGAGFGLVGVGTALAMARKGAQLGLVAFRRHYMITLEVPARDRSYAWLLSWLTRHSTRTQHLSVETSYLQHESGRISTKFEFIPSPGNHFIWYQGKWIRVERNRDMQMVDLQTGTPWESVTFTALGTDRKVFFNILEEARALALQQEEGKTVMYTAVGSEWRTFGYPRRRRPLDSVVLQQGLADRIVKDIREFIDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSSLSDDRLNHLLSVAPQQSLVLLEDVDAAFLSRDLAVENPIKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNYIDRLDPALIRPGRVDLKEYVGYCSHWQLTQMFQRFYPGQAPSLAENFAEHVLKATSEISPAQVQGYFMLYKNDPMGAVHNIESLR", "length": 418 }, "evidence": [ { "id": "Q5E9H5", "url": "https://omabrowser.org/oma/group/Q5E9H5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VL22-1", "protein_name": "Mitochondrial chaperone BCS1", "gene_name": "Bcs1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTLPDLVAGLSSNPYFGAGFGLFGVGAAAAILRKGLQGGVILFRRHCMITLEVPCRDKSYQWLLKWITIRGARKTQHLSVETNFVQNDNGTIKTSYDFIPSIGKHLFQYKGNWIQVERTREQQTLDLHMGVPWETVTLTAFGNNKGIYFDILEEARQLALEATEGKTVLYTAMGAEWRPFGHPRRRRPTGSVVLDRGTSQRIIADCQDFIKSSLWYTQRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSVCLLNLSERGLTDDRLNHLLNVAPEQSIILLEDIDAAFVSREATPQQKSAFDGLNRITFSGLLNCLDGVGSTEARIVFMTTNYIDRLDPALVRPGRIDLKEYIGYCTQYQLEEMFKNFFASSDTTKAEEFGKRVNSFGRSASPAQIQGFFMKHKLSSPQTVIDSCEDIWENVLDHNKKIN", "length": 431 }, "evidence": [ { "id": "Q5E9H5", "url": "https://omabrowser.org/oma/group/Q5E9H5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y276-1", "protein_name": "Mitochondrial chaperone BCS1", "gene_name": "BCS1L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPLSDFILALKDNPYFGAGFGLVGVGTALALARKGVQLGLVAFRRHYMITLEVPARDRSYAWLLSWLTRHSTRTQHLSVETSYLQHESGRISTKFEFVPSPGNHFIWYRGKWIRVERSREMQMIDLQTGTPWESVTFTALGTDRKVFFNILEEARELALQQEEGKTVMYTAVGSEWRPFGYPRRRRPLNSVVLQQGLADRIVRDVQEFIDNPKWYTDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSSLSDDRLNHLLSVAPQQSLVLLEDVDAAFLSRDLAVENPVKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNHVDRLDPALIRPGRVDLKEYVGYCSHWQLTQMFQRFYPGQAPSLAENFAEHVLRATNQISPAQVQGYFMLYKNDPVGAIHNAESLRR", "length": 419 }, "evidence": [ { "id": "Q5E9H5", "url": "https://omabrowser.org/oma/group/Q5E9H5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H5", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H5", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H5", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H5", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ], "pmid": "" }, { "name": "mitochondrial respiratory chain complex IV assembly", "id": "GO:0033617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033617", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H5", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ], "pmid": "" }, { "name": "mitochondrial respiratory chain complex III assembly", "id": "GO:0034551", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034551", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H5", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ], "pmid": "" }, { "name": "protein insertion into mitochondrial inner membrane from matrix", "id": "GO:0032979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032979", "evidence": [ { "database": "UniProtKB", "id": "Q5E9H5", "url": "https://www.uniprot.org/uniprotkb/Q5E9H5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": 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}, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { 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"url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9H5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 181 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9I7-1", "uniprot_ac": "Q5E9I7", "uniprot_id": "MEP50_BOVIN", "mass": { "chemical_mass": 36789.0, "monoisotopic_mass": 36789.0 }, "refseq": { "ac": "NP_001015584", "name": "methylosome protein WDR77", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015584" }, "gene_names": [ { "name": "WDR77", "type": "recommended", "evidence": [ { "id": "Q5E9I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9I7" } ] }, { "name": "MEP50", "type": "synonym", "evidence": [ { "id": "NP_001015584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015584" }, { "id": "Q5E9I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9I7" } ] }, { "name": "WDR77", "type": "synonym", "evidence": [ { "id": "NP_001015584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015584" } ] } ], "protein_names": [ { "name": "Methylosome protein WDR77", "type": "recommended", "evidence": [ { "id": "Q5E9I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9I7/entry#names_and_taxonomy" } ] }, { "name": "MEP-50", "type": "synonym", "evidence": [ { "id": "NP_001015584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015584" }, { "id": "Q5E9I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9I7/entry#names_and_taxonomy" } ] }, { "name": "Methylosome protein 50", "type": "synonym", "evidence": [ { "id": "Q5E9I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9I7/entry#names_and_taxonomy" } ] }, { "name": "WD repeat-containing protein 77", "type": "synonym", "evidence": [ { "id": "NP_001015584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015584" }, { "id": "Q5E9I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9I7/entry#names_and_taxonomy" } ] }, { "name": "methylosome protein 50", "type": "synonym", "evidence": [ { "id": "NP_001015584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015584" } ] }, { "name": "methylosome protein WDR77", "type": "synonym", "evidence": [ { "id": "NP_001015584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015584" } ] } ], "function": [ { "annotation": "Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I7", "url": "https://www.uniprot.org/uniprotkb/Q5E9I7#function" }, { "database": "UniProtKB", "id": "Q9BQA1", "url": "https://www.uniprot.org/uniprotkb/Q9BQA1#function" }, { "database": "UniProtKB", "id": "Q99J09", "url": "https://www.uniprot.org/uniprotkb/Q99J09#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9I7", "url": "https://www.uniprot.org/uniprotkb/Q5E9I7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR77", "url": "https://www.uniprot.org/uniprotkb/Q5E9I7", "locus": { "chromosome": "3", "start_pos": 31880047, "end_pos": 31863581, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014102", "url": "https://www.ensembl.org/id/ENSBTAG00000014102" } ] } } ], "crossref": [ { "id": "Q5E9I7", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9I7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014102", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014102", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512993", "url": "https://www.ncbi.nlm.nih.gov/gene/512993", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052139", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052139", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512993", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512993", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QMGCNAS", "url": "https://omabrowser.org/oma/group/QMGCNAS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9I7", "url": "https://www.orthodb.org/?gene=Q5E9I7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46853", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46853", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46853:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46853:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-191859", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-191859", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3214858", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214858", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015584", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9I7", "url": "https://www.uniprot.org/uniprotkb/Q5E9I7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9I7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGDRGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTHAVSGSKDFCIKVWDLAQQMVLNSYRAHSGQVTCVAASPHKDSVFLSCGEDNRILLWDTRCPKPASQMGCSASGYLPTSLTWHPQQSEVFVFGDENGTVSLVDTKSAGCAVSSVVHSQCVTGLVFSPHSAPFLASVSEDCSLAVLDSGLSEVFRSRAHRDFVRDATWSPLNHSLLTTVGWDHQVIHHILPTEPLPEPGPKSAAE", "length": 342, "header": "sp|Q5E9I7-1|MEP50_BOVIN Isoform 1 of Methylosome protein WDR77 OS=Bos taurus OX=9913 GN=WDR77 PE=2 SV=1 CANONICAL=Q5E9I7-1" }, "isoforms": [ { "isoform_ac": "Q5E9I7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9I7/entry#Q5E9I7-1", "sequence": { "sequence": "MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGDRGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTHAVSGSKDFCIKVWDLAQQMVLNSYRAHSGQVTCVAASPHKDSVFLSCGEDNRILLWDTRCPKPASQMGCSASGYLPTSLTWHPQQSEVFVFGDENGTVSLVDTKSAGCAVSSVVHSQCVTGLVFSPHSAPFLASVSEDCSLAVLDSGLSEVFRSRAHRDFVRDATWSPLNHSLLTTVGWDHQVIHHILPTEPLPEPGPKSAAE", "length": 342, "header": "sp|Q5E9I7-1|MEP50_BOVIN Isoform 1 of Methylosome protein WDR77 OS=Bos taurus OX=9913 GN=WDR77 PE=2 SV=1 CANONICAL=Q5E9I7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 5, "end_pos": 5, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I7", "url": "https://www.uniprot.org/uniprotkb/Q5E9I7" } ], "site_lbl": "Thr5" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9I7", "url": "https://www.uniprot.org/uniprotkb/Q5E9I7" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:512993", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512993", "resource": "KEGG Pathway" }, { "id": "R-BTA-191859", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-191859", "resource": "Reactome", "description": "snRNP Assembly" }, { "id": "R-BTA-3214858", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214858", "resource": "Reactome", "description": "RMTs methylate histone arginines" } ], "orthologs": [ { "uniprot_canonical_ac": "F1S8D4-1", "protein_name": "Methylosome protein WDR77", "gene_name": "WDR77", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRKETPPSLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGDRGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSSVSVLSSGTQAVSGSKDFCIKVWDLAQQMVLNSYRAHSGQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGYRASGYLPTSLAWHPQRSEVFVFGDENGTVSLVDTKSASCALSATVHSQSVTGLVFSPHSTPFLASVSEDCSLAVLDSGLSKVFRSRAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHILPTEPFPEPGLKSAAE", "length": 342 }, "evidence": [ { "id": "Q5E9I7", "url": "https://omabrowser.org/oma/group/Q5E9I7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q4QR85-1", "protein_name": "Methylosome protein WDR77", "gene_name": "Wdr77", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRKESPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGSLLLGASSLSGRCWAGSLWFFKDPSAAPNEGFCSAGVQTEAGVADLTWVGDKGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVTVLSSGTQAVSGSKDFCIKIWDLAQQMSLNSYRAHAGQVTCVAASPHRETVFLSCSEDSRILLWDTRCPKPASQMGCNASGYLPTSLAWHPQQSEIFVFGDENGSVSLVDTKNASCTLSSAVHSQCVTRLVFSPHSVPFLASLSEDCSLAVLDSSFSEVFRSRAHRDFVRDATWSPLNHSLLTTVGWDHQVIHHVVPLEPLPAPGPDSVVE", "length": 342 }, "evidence": [ { "id": "Q5E9I7", "url": "https://omabrowser.org/oma/group/Q5E9I7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99J09-1", "protein_name": "Methylosome protein WDR77", "gene_name": "Wdr77", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRKDTPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGSLLLGVSSLSGRCWVGSLWFFKDPSAAPNEGFCSAGVQTEAGVADLTWVGDKGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVTVLSSGTQAVSGSKDCCIKIWDLAQQVSLNSYRAHAGQVTCVAASPHKDSVFLSCSEDSRILLWDTRCPKPASQMACNASGYLPTALAWHPQQSEVFVFGDENGSVSLVDTKNASCTLSSAVHSQGVTRLVFSPHSVPLLTSLSEDCSLAVLDSSLSEVFRSRAHRDFVRDATWSPLNHSLLTTVGWDHQVIHHVVPLEPLPNPGPDSVVE", "length": 342 }, "evidence": [ { "id": "Q5E9I7", "url": "https://omabrowser.org/oma/group/Q5E9I7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BQA1-1", "protein_name": "Methylosome protein WDR77", "gene_name": "WDR77", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9J1-1", "uniprot_ac": "Q5E9J1", "uniprot_id": "HNRPF_BOVIN", "mass": { "chemical_mass": 45689.0, "monoisotopic_mass": 45689.0 }, "refseq": { "ac": "NP_001014860", "name": "heterogeneous nuclear ribonucleoprotein F", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014860" }, "gene_names": [ { "name": "HNRNPF", "type": "recommended", "evidence": [ { "id": "Q5E9J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" } ] }, { "name": "HNRNPF", "type": "synonym", "evidence": [ { "id": "NP_001014860", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014860" } ] }, { "name": "HNRPF", "type": "synonym", "evidence": [ { "id": "NP_001014860", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014860" }, { "id": "Q5E9J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" } ] } ], "protein_names": [ { "name": "Heterogeneous nuclear ribonucleoprotein F", "type": "recommended", "evidence": [ { "id": "Q5E9J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1/entry#names_and_taxonomy" } ] }, { "name": "heterogeneous nuclear ribonucleoprotein F", "type": "synonym", "evidence": [ { "id": "NP_001014860", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014860" } ] }, { "name": "hnRNP F", "type": "synonym", "evidence": [ { "id": "NP_001014860", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014860" }, { "id": "Q5E9J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9J1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HNRNPF", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1", "locus": { "chromosome": "28", "start_pos": 13799720, "end_pos": 13823103, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008853", "url": "https://www.ensembl.org/id/ENSBTAG00000008853" } ] } } ], "crossref": [ { "id": "Q5E9J1", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9J1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008853", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008853", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12506", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12506", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12729", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12729", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12731", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12731", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506917", "url": "https://www.ncbi.nlm.nih.gov/gene/506917", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012996", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012996", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506917", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506917", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YYNDEYE", "url": "https://omabrowser.org/oma/group/YYNDEYE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9J1", "url": "https://www.orthodb.org/?gene=Q5E9J1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13976", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13976", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08080", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08080", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF28441", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28441", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72203", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72203", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9770562", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770562", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001014860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014860", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9J1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9J1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMLGPEGGEGFVVKLRGLPWSCSVEDVQNFLSDCTIHDGVAGVHFIYTREGRQSGEAFVELESEDDVKLALKKDRESMGHRYIEVFKSHRTEMDWVLKHSGPNSADTANDGFVRLRGLPFGCTKEEIIQFFSGLEIVPNGITLPVDPEGKITGEAFVQFASQELAEKALGKHKERIGHRYIEVFKSSQEEVRSYSDPPLKFMSVQRPGPYDRPGTARRYIGIVKQAGLERMRSGAYSAGYGGYEEYSGLSDGYGFTTDLFGRDLSYCLSGMYDHRYGDGEFTVQSTTGHCVHMRGLPYKATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEEAVAAMSKDRANMQHRYIELFLNSTTGASNGAYSSQMMQGMGVSTQSTYSGLESQSVSGCYGAGYGGQNSMGGYD", "length": 414, "header": "sp|Q5E9J1-1|HNRPF_BOVIN Isoform 1 of Heterogeneous nuclear ribonucleoprotein F OS=Bos taurus OX=9913 GN=HNRNPF PE=2 SV=3 CANONICAL=Q5E9J1-1" }, "isoforms": [ { "isoform_ac": "Q5E9J1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1/entry#Q5E9J1-1", "sequence": { "sequence": "MMLGPEGGEGFVVKLRGLPWSCSVEDVQNFLSDCTIHDGVAGVHFIYTREGRQSGEAFVELESEDDVKLALKKDRESMGHRYIEVFKSHRTEMDWVLKHSGPNSADTANDGFVRLRGLPFGCTKEEIIQFFSGLEIVPNGITLPVDPEGKITGEAFVQFASQELAEKALGKHKERIGHRYIEVFKSSQEEVRSYSDPPLKFMSVQRPGPYDRPGTARRYIGIVKQAGLERMRSGAYSAGYGGYEEYSGLSDGYGFTTDLFGRDLSYCLSGMYDHRYGDGEFTVQSTTGHCVHMRGLPYKATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEEAVAAMSKDRANMQHRYIELFLNSTTGASNGAYSSQMMQGMGVSTQSTYSGLESQSVSGCYGAGYGGQNSMGGYD", "length": 414, "header": "sp|Q5E9J1-1|HNRPF_BOVIN Isoform 1 of Heterogeneous nuclear ribonucleoprotein F OS=Bos taurus OX=9913 GN=HNRNPF PE=2 SV=3 CANONICAL=Q5E9J1-1" }, "locus": { "chromosome": "28", "start_pos": 13805663, "end_pos": 13804422, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095286.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095286.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103818.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103818.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 104, "end_pos": 104, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" } ], "site_lbl": "Ser104" }, { "start_pos": 161, "end_pos": 161, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" } ], "site_lbl": "Ser161" }, { "start_pos": 187, "end_pos": 187, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" } ], "site_lbl": "Ser187" }, { "start_pos": 193, "end_pos": 193, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" } ], "site_lbl": "Ser193" }, { "start_pos": 195, "end_pos": 195, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" } ], "site_lbl": "Ser195" }, { "start_pos": 215, "end_pos": 215, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" } ], "site_lbl": "Thr215" }, { "start_pos": 265, "end_pos": 265, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" } ], "site_lbl": "Ser265" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:506917", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506917", "resource": "KEGG Pathway" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" }, { "id": "R-BTA-72203", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72203", "resource": "Reactome", "description": "Processing of Capped Intron-Containing Pre-mRNA" }, { "id": "R-BTA-9770562", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770562", "resource": "Reactome", "description": "mRNA Polyadenylation" } ], "orthologs": [ { "uniprot_canonical_ac": "P52597-1", "protein_name": "Heterogeneous nuclear ribonucleoprotein F", "gene_name": "HNRNPF", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMLGPEGGEGFVVKLRGLPWSCSVEDVQNFLSDCTIHDGAAGVHFIYTREGRQSGEAFVELGSEDDVKMALKKDRESMGHRYIEVFKSHRTEMDWVLKHSGPNSADSANDGFVRLRGLPFGCTKEEIVQFFSGLEIVPNGITLPVDPEGKITGEAFVQFASQELAEKALGKHKERIGHRYIEVFKSSQEEVRSYSDPPLKFMSVQRPGPYDRPGTARRYIGIVKQAGLERMRPGAYSTGYGGYEEYSGLSDGYGFTTDLFGRDLSYCLSGMYDHRYGDSEFTVQSTTGHCVHMRGLPYKATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEEAVAAMSKDRANMQHRYIELFLNSTTGASNGAYSSQVMQGMGVSAAQATYSGLESQSVSGCYGAGYSGQNSMGGYD", "length": 415 }, "evidence": [ { "id": "Q5E9J1", "url": "https://omabrowser.org/oma/group/Q5E9J1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q794E4-1", "protein_name": "Heterogeneous nuclear ribonucleoprotein F", "gene_name": "Hnrnpf", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMLGPEGGEGYVVKLRGLPWSCSIEDVQNFLSDCTIHDGVAGVHFIYTREGRQSGEAFVELESEDDVKLALKKDRESMGHRYIEVFKSHRTEMDWVLKHSGPNSADSANDGFVRLRGLPFGCTKEEIVQFFSGLEIVPNGITLPVDPEGKITGEAFVQFASQELAEKALGKHKERIGHRYIEVFKSSQEEVRSYSDPPLKFMSVQRPGPYDRPGTARRYIGIVKQAGLDRMRSGAYSAGYGGYEEYSGLSDGYGFTTDLFGRDLSYCLSGMYDHRYGDSEFTVQSTTGHCVHMRGLPYKATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEEAVAAMSKDRANMQHRYIELFLNSTTGASNGAYSSQVMQGMGVSAAQATYSGLESQSVSGCYGAGYSGQNSMGGYD", "length": 415 }, "evidence": [ { "id": "Q5E9J1", "url": "https://omabrowser.org/oma/group/Q5E9J1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9Z2X1-1", "protein_name": "Heterogeneous nuclear ribonucleoprotein F", "gene_name": "Hnrnpf", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMLGPEGGEGYVVKLRGLPWSCSIEDVQNFLSDCTIHDGVAGVHFIYTREGRQSGEAFVELESEDDVKLALKKDRESMGHRYIEVFKSHRTEMDWVLKHSGPNSADSANDGFVRLRGLPFGCTKEEIVQFFSGLEIVPNGITLPVDPEGKITGEAFVQFASQELAEKALGKHKERIGHRYIEVFKSSQEEVRSYSDPPLKFMSVQRPGPYDRPGTARRYIGIVKQAGLDRMRSGAYSAGYGGYEEYSGLSDGYGFTTDLFGRDLSYCLSGMYDHRYGDSEFTVQSTTGHCVHMRGLPYKATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEEAVAAMSKDRANMQHRYIELFLNSTTGASNGAYSSQVMQGMGVSAAQATYSGLESQSVSGCYGAGYSGQNSMGGYD", "length": 415 }, "evidence": [ { "id": "Q5E9J1", "url": "https://omabrowser.org/oma/group/Q5E9J1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" } ], "pmid": "" }, { "name": "single-stranded RNA binding", "id": "GO:0003727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003727", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" } ], "pmid": "" }, { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" } ], "pmid": "" }, { "name": "regulation of RNA splicing", "id": "GO:0043484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043484", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 362, "end_pos": 364, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9J1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 414, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9J1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9J1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5E9J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM 1", "eco_id": "ECO_0000255", "start_pos": 11, "end_pos": 90, "start_aa": "Phe", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5E9J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM 2", "eco_id": "ECO_0000255", "start_pos": 111, "end_pos": 188, "start_aa": "Gly", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5E9J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J1" }, { "id": "PRU00176", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00176" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM 3", "eco_id": "ECO_0000255", "start_pos": 289, "end_pos": 366, "start_aa": "His", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 104, 161, 187, 193, 195, 215, 265 ], "sequon_annotation_sites": [ { "start_pos": 362, "end_pos": 364 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 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}, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9J4-1", "uniprot_ac": "Q5E9J4", "uniprot_id": "IFT22_BOVIN", "mass": { "chemical_mass": 20872.0, "monoisotopic_mass": 20872.0 }, "refseq": { "ac": "NP_001015612", "name": "intraflagellar transport protein 22 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015612" }, "gene_names": [ { "name": "IFT22", "type": "recommended", "evidence": [ { "id": "Q5E9J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J4" } ] }, { "name": "IFT22", "type": "synonym", "evidence": [ { "id": "NP_001015612", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015612" } ] }, { "name": "RABL5", "type": "synonym", 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"https://www.ncbi.nlm.nih.gov/protein/NP_001015612" } ] }, { "name": "rab-like protein 5", "type": "synonym", "evidence": [ { "id": "NP_001015612", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015612" } ] } ], "function": [ { "annotation": "Small GTPase-like component of the intraflagellar transport (IFT) complex B.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J4", "url": "https://www.uniprot.org/uniprotkb/Q5E9J4#function" }, { "database": "UniProtKB", "id": "A0ABI0NRX7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRX7#function" }, { "database": "UniProtKB", "id": "ARBA00037285", "url": "https://www.uniprot.org/uniprotkb/ARBA00037285#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9J4", "url": "https://www.uniprot.org/uniprotkb/Q5E9J4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IFT22", "url": "https://www.uniprot.org/uniprotkb/Q5E9J4", "locus": { "chromosome": "25", "start_pos": 35414986, "end_pos": 35410034, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014343", "url": "https://www.ensembl.org/id/ENSBTAG00000014343" } ] } } ], "crossref": [ { "id": "Q5E9J4", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9J4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014343", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014343", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "516107", "url": "https://www.ncbi.nlm.nih.gov/gene/516107", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516107", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516107", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NERHDQE", "url": "https://omabrowser.org/oma/group/NERHDQE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9J4", "url": "https://www.orthodb.org/?gene=Q5E9J4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24073", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24073", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08477", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08477", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5620924", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620924", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015612", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NRX7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NRX7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRX7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9J4", "url": "https://www.uniprot.org/uniprotkb/Q5E9J4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9J4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9J4-2", "url": "https://www.uniprot.org/uniprotkb/Q5E9J4-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLKAKILFVGPCESGKTVLANFLTESSDITEYNPTQGVRILEFENPHVTSNNKGTGCEFELWDCGGDPKFESCWPALMKDSHGVVIVFNADIPSHLKEIETWYSCFVQQQFLQNTQCLLIAHHKPGSGSDKDNPALAPPLNKLKLVHSNLEDDPEEIRMEFIKYLRSIINSVSESRDREEMSIIT", "length": 185, "header": "sp|Q5E9J4-1|IFT22_BOVIN Isoform 1 of Intraflagellar transport protein 22 homolog OS=Bos taurus OX=9913 GN=IFT22 PE=2 SV=1 CANONICAL=Q5E9J4-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NRX7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J4/entry#A0ABI0NRX7-1", "sequence": { "sequence": "KSVLPTTQSGGKTVLANFLTESSDITEYNPTQGVRILEFENPHVTSNNKGTGCEFELWDCGGDPKFESCWPALMKDSHGVVIVFNADIPSHLKEIETWYSCFVQQQFLQNTQCLLIAHHKPGSGSDKDNPALAPPLNKLKLVHSNLEDDPEEIRMEFIKYLRSIINSVSESRDREEMSIIT", "length": 181, "header": "tr|A0ABI0NRX7-1|A0ABI0NRX7_BOVIN Computationally mapped isoform of Intraflagellar transport protein 22 homolog OS=Bos taurus OX=9913 GN=IFT22 PE=3 SV=1 CANONICAL=Q5E9J4-1" }, "locus": { "chromosome": "25", "start_pos": 35414459, "end_pos": 35411963, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153136.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153136.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105591.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105591.1" } ] } }, { "isoform_ac": "Q5E9J4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J4/entry#Q5E9J4-1", "sequence": { "sequence": "MLKAKILFVGPCESGKTVLANFLTESSDITEYNPTQGVRILEFENPHVTSNNKGTGCEFELWDCGGDPKFESCWPALMKDSHGVVIVFNADIPSHLKEIETWYSCFVQQQFLQNTQCLLIAHHKPGSGSDKDNPALAPPLNKLKLVHSNLEDDPEEIRMEFIKYLRSIINSVSESRDREEMSIIT", "length": 185, "header": "sp|Q5E9J4-1|IFT22_BOVIN Isoform 1 of Intraflagellar transport protein 22 homolog OS=Bos taurus OX=9913 GN=IFT22 PE=2 SV=1 CANONICAL=Q5E9J4-1" }, "locus": { "chromosome": "25", "start_pos": 35414459, "end_pos": 35410075, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000137922.1", "url": "https://www.ensembl.org/id/ENSBTAT00000137922.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106859.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106859.1" } ] } }, { "isoform_ac": "Q5E9J4-2", "url": "https://www.uniprot.org/uniprotkb/Q5E9J4/entry#Q5E9J4-2", "sequence": { "sequence": "MLKAKILFVGPCESGKTVLANFLTESSDITEYNPTQGVRFESCWPALMKDSHGVVIVFNADIPSHLKEIETWYSCFVQQQFLQNTQCLLIAHHKPGSGSDKDNPALAPPLNKLKLVHSNLEDDPEEIRMEFIKYLRSIINSVSESRDREEMSIIT", "length": 155, "header": "sp|Q5E9J4-2|IFT22_BOVIN Isoform 2 of Intraflagellar transport protein 22 homolog OS=Bos taurus OX=9913 GN=IFT22 PE=2 SV=1 CANONICAL=Q5E9J4-1" }, "locus": { "chromosome": "25", "start_pos": 35414459, "end_pos": 35410075, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019073.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019073.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019073.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019073.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J4", "url": "https://www.uniprot.org/uniprotkb/Q5E9J4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:516107", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516107", "resource": "KEGG Pathway" }, { "id": "R-BTA-5620924", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620924", "resource": "Reactome", "description": "Intraflagellar transport" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1UHM6-1", "protein_name": "Intraflagellar transport protein 22 homolog", "gene_name": "IFT22", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLKAKILFVGPCESGKTVLANFLTESSDITEYHPTQGVRILEFENPHVTSNNKGTGCEFELWDCGGDPKFESCWPALMKDSHGVVIVFNADIPSHLTEIEMWYSCFVQQQFLQDTQCLLIAHHKPGSGSDKGNPTLSPPLNKLKLVHSNLEDDPEEMRMEFIKYLRSIINSVSESRDREEMSIIT", "length": 185 }, "evidence": [ { "id": "Q5E9J4", "url": "https://omabrowser.org/oma/group/Q5E9J4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q567Y6-1", "protein_name": "Intraflagellar transport protein 22 homolog", "gene_name": "ift22", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFKVKILLIGPSECGKTALANFLSDTTESIGADYSPTQGVRILEFESHNLHNGNKSSSCDVELWDCAGDFKFESCWPALMKDSNGVAVVFNPDVPSHLKEIETWYSAFISSQGLLEGQCLLIAHHKPGSGADTNRPSLAPQLNKLPLIHSNLEEEPEEVRQEFNKYLGKVMRMLSESQEREEMSIIT", "length": 187 }, "evidence": [ { "id": "Q5E9J4", "url": "https://omabrowser.org/oma/group/Q5E9J4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5FVJ7-1", "protein_name": "Intraflagellar transport protein 22 homolog", "gene_name": "Ift22", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLKAKILFVGPCESGKTVLANFLTESSDITEYNPTQGVRILEFENPHVTSNNKGTGCEFELWDCGGDSKFESCWPALMKDAHGVVIVFNADIPSHLKEIEMWYSCFVQQQFLQDSHCMLVAHHKPGSGGDKSNLALSPPLNKLKLVHSNLEEDPEEVRVEFIKYLKSIINSMSESRDREEMLIIT", "length": 185 }, "evidence": [ { "id": "Q5E9J4", "url": "https://omabrowser.org/oma/group/Q5E9J4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9DAI2-1", "protein_name": "Intraflagellar transport protein 22 homolog", "gene_name": "Ift22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLKAKILFVGPCESGKTVLANFLTESSDITEYNPTQGVRILEFENPHVTSNNKGTGCEFELWDCGGDSKFESCWPALMKDAHGVVIVFNADIPSHLKEIEMWYSCFVQQQFLQDSHCMLVAHHKPGSGGERGSLALSPPLNKLKLVHSNLEEDPEEVRVEFIKYLKSIINSMSESRDREEMLIIT", "length": 185 }, "evidence": [ { "id": "Q5E9J4", "url": "https://omabrowser.org/oma/group/Q5E9J4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H7X7-1", "protein_name": "Intraflagellar transport protein 22 homolog", "gene_name": "IFT22", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLKAKILFVGPCESGKTVLANFLTESSDITEYSPTQGVRILEFENPHVTSNNKGTGCEFELWDCGGDAKFESCWPALMKDAHGVVIVFNADIPSHRKEMEMWYSCFVQQPSLQDTQCMLIAHHKPGSGDDKGSLSLSPPLNKLKLVHSNLEDDPEEIRMEFIKYLKSIINSMSESRDREEMSIMT", "length": 185 }, "evidence": [ { "id": "Q5E9J4", "url": "https://omabrowser.org/oma/group/Q5E9J4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J4", "url": "https://www.uniprot.org/uniprotkb/Q5E9J4" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J4", "url": "https://www.uniprot.org/uniprotkb/Q5E9J4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J4", "url": "https://www.uniprot.org/uniprotkb/Q5E9J4" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J4", "url": "https://www.uniprot.org/uniprotkb/Q5E9J4" } ], "pmid": "" }, { "name": "intraciliary transport particle B", "id": "GO:0030992", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030992", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J4", "url": "https://www.uniprot.org/uniprotkb/Q5E9J4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J4", "url": "https://www.uniprot.org/uniprotkb/Q5E9J4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9J4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 185, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9J4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9J4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9J5-1", "uniprot_ac": "Q5E9J5", "uniprot_id": "DHCR7_BOVIN", "mass": { "chemical_mass": 54271.0, "monoisotopic_mass": 54271.0 }, "refseq": { "ac": "NP_001014927", "name": "7-dehydrocholesterol reductase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014927" }, "gene_names": [ { "name": "DHCR7", "type": "recommended", "evidence": [ { "id": "Q5E9J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5" } ] }, { "name": "DHCR7", "type": "synonym", "evidence": [ { "id": "NP_001014927", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014927" } ] } ], "protein_names": [ { "name": "7-dehydrocholesterol reductase", "type": "recommended", "evidence": [ { "id": "Q5E9J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5/entry#names_and_taxonomy" } ] }, { "name": "1.3.1.21", "type": "synonym", "evidence": [ { "id": "Q5E9J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5/entry#names_and_taxonomy" } ] }, { "name": "3.3.2.11", "type": "synonym", "evidence": [ { "id": "Q5E9J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5/entry#names_and_taxonomy" } ] }, { "name": "7-DHC reductase", "type": "synonym", "evidence": [ { "id": "NP_001014927", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014927" }, { "id": "Q5E9J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5/entry#names_and_taxonomy" } ] }, { "name": "7-dehydrocholesterol reductase", "type": "synonym", "evidence": [ { "id": "NP_001014927", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014927" } ] }, { "name": "Cholesterol-5,6-epoxide hydrolase subunit DHCR7", "type": "synonym", "evidence": [ { "id": "Q5E9J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5/entry#names_and_taxonomy" } ] }, { "name": "Sterol Delta(7)-reductase", "type": "synonym", "evidence": [ { "id": "Q5E9J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5/entry#names_and_taxonomy" } ] }, { "name": "cholesterol-5,6-epoxide hydrolase subunit DHCR7", "type": "synonym", "evidence": [ { "id": "NP_001014927", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014927" } ] }, { "name": "sterol Delta(7)-reductase", "type": "synonym", "evidence": [ { "id": "NP_001014927", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014927" } ] } ], "function": [ { "annotation": "Component of the microsomal antiestrogen binding site (AEBS), a multiproteic complex at the ER membrane that consists of an association between cholestenol Delta-isomerase/EBP and DHCR7. This complex is responsible for cholesterol-5,6-epoxide hydrolase (ChEH) activity, which consists in the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3beta,5alpha,6beta-triol (CT). The precise role of each component of this complex has not been described yet.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J5", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5#function" }, { "database": "UniProtKB", "id": "Q9UBM7", "url": "https://www.uniprot.org/uniprotkb/Q9UBM7#function" } ] }, { "annotation": "Oxidoreductase that catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core (By similarity). Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta(24)-sterol reductase (DHCR24) to cholesterol (By similarity). Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J5", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5#function" }, { "database": "UniProtKB", "id": "Q9UBM7", "url": "https://www.uniprot.org/uniprotkb/Q9UBM7#function" }, { "database": "UniProtKB", "id": "O88455", "url": "https://www.uniprot.org/uniprotkb/O88455#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9J5", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DHCR7", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5", "locus": { "chromosome": "29", "start_pos": 48285096, "end_pos": 48304702, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016465", "url": "https://www.ensembl.org/id/ENSBTAG00000016465" } ] } } ], "crossref": [ { "id": "Q5E9J5", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9J5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016465", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016465", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514745", "url": "https://www.ncbi.nlm.nih.gov/gene/514745", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001171", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001171", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514745", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514745", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KYGQYWA", "url": "https://omabrowser.org/oma/group/KYGQYWA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9J5", "url": "https://www.orthodb.org/?gene=Q5E9J5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21257", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21257", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21257:SF38", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21257:SF38", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01222", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01222", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6807047", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807047", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9969901", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9969901", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001014927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014927", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11964", "url": "https://www.rhea-db.org/rhea/11964", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "15113", "url": "https://www.rhea-db.org/rhea/15113", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "23984", "url": "https://www.rhea-db.org/rhea/23984", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46740", "url": "https://www.rhea-db.org/rhea/46740", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9J5", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9J5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAKSQPSAPKTKSTSGLTNGNAAAQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYGCSLTVPVADLATGRARLADIWARTPPVTAKAAQIYTAWVTLQVLLYMLLPDFCHKFLPGYVGGVQEGAVTPAGAVNKYEINGLQAWLLTHLLWFANAHLLGWFSPTIIFDNWIPLLWCANILGYTVSTFAMVKGYLFPTDARECKFTGNFFYNYMMGVEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQQELYGHVTNSMVLVNILQAIYVLDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLPTYYALGVLLLGLLGYYIFRMTNHQKDLFRRTDGRCLIWGRKPKAIECSYTSADGQRHHSKLLVSGFWGVARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIFMAILLTHRCLRDEHRCANKYGRDWEHYTAAVPYRLLPGIF", "length": 475, "header": "sp|Q5E9J5-1|DHCR7_BOVIN Isoform 1 of 7-dehydrocholesterol reductase OS=Bos taurus OX=9913 GN=DHCR7 PE=2 SV=1 CANONICAL=Q5E9J5-1" }, "isoforms": [ { "isoform_ac": "Q5E9J5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5/entry#Q5E9J5-1", "sequence": { "sequence": "MAAKSQPSAPKTKSTSGLTNGNAAAQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYGCSLTVPVADLATGRARLADIWARTPPVTAKAAQIYTAWVTLQVLLYMLLPDFCHKFLPGYVGGVQEGAVTPAGAVNKYEINGLQAWLLTHLLWFANAHLLGWFSPTIIFDNWIPLLWCANILGYTVSTFAMVKGYLFPTDARECKFTGNFFYNYMMGVEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQQELYGHVTNSMVLVNILQAIYVLDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLPTYYALGVLLLGLLGYYIFRMTNHQKDLFRRTDGRCLIWGRKPKAIECSYTSADGQRHHSKLLVSGFWGVARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIFMAILLTHRCLRDEHRCANKYGRDWEHYTAAVPYRLLPGIF", "length": 475, "header": "sp|Q5E9J5-1|DHCR7_BOVIN Isoform 1 of 7-dehydrocholesterol reductase OS=Bos taurus OX=9913 GN=DHCR7 PE=2 SV=1 CANONICAL=Q5E9J5-1" }, "locus": { "chromosome": "29", "start_pos": 48296297, "end_pos": 48286336, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021892.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021892.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021892.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021892.6" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 14, "end_pos": 14, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J5", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5" } ], "site_lbl": "Ser14" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J5", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:514745", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514745", "resource": "KEGG Pathway" }, { "id": "R-BTA-6807047", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807047", "resource": "Reactome", "description": "Cholesterol biosynthesis via desmosterol (Bloch pathway)" }, { "id": "R-BTA-9969901", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9969901", "resource": "Reactome", "description": "Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9UBM7-1", "protein_name": "7-dehydrocholesterol reductase", "gene_name": "DHCR7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF", "length": 475 }, "evidence": [ { "id": "Q5E9J5", "url": "https://omabrowser.org/oma/group/Q5E9J5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "7-dehydrocholesterol reductase activity", "id": "GO:0047598", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047598", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J5", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5" } ], "pmid": "" }, { "name": "NADP binding", "id": "GO:0050661", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050661", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J5", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5" } ], "pmid": "" }, { "name": "cholesterol-5,6-oxide hydrolase activity", "id": "GO:0033963", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033963", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J5", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J5", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5" } ], "pmid": "" }, { "name": "nuclear outer membrane", "id": "GO:0005640", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005640", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J5", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cholesterol biosynthetic process", "id": "GO:0006695", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006695", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J5", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5" } ], "pmid": "" }, { "name": "cholesterol biosynthetic process via lathosterol", "id": "GO:0033490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033490", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J5", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5" } ], "pmid": "" }, { "name": "positive regulation of ferroptosis", "id": "GO:0160020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160020", "evidence": [ { "database": "UniProtKB", "id": "Q5E9J5", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 252, "end_pos": 254, "annotation": "n_glycosylation_sequon" }, { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" }, { "start_pos": 407, "end_pos": 409, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11964", "name": "", "equation": "5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9J5-1" ], "evidence": [ { "id": "11964", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11964" } ] }, { "id": "15113", "name": "", "equation": "5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9J5-1" ], "evidence": [ { "id": "15113", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15113" } ] }, { "id": "23984", "name": "", "equation": "cholesterol + NADP(+) = 7-dehydrocholesterol + NADPH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9J5-1" ], "evidence": [ { "id": "23984", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23984" } ] }, { "id": "46740", "name": "", "equation": "7-dehydrodesmosterol + NADPH + H(+) = desmosterol + NADP(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9J5-1" ], "evidence": [ { "id": "46740", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46740" } ] }, { "id": "R-BTA-196402", "name": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-195655" ], "output_participant_list": [ "R-ALL-196420" ], "enzyme_list": [ "Q5E9J5-1" ], "evidence": [ { "id": "R-BTA-196402", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196402" } ] }, { "id": "R-BTA-6807055", "name": "DHCR7 reduces 7-dehydroCHOL to CHOL", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-6807057" ], "output_participant_list": [], "enzyme_list": [ "Q5E9J5-1" ], "evidence": [ { "id": "R-BTA-6807055", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807055" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-195655", "participant_name": "7dhDESOL [endoplasmic reticulum membrane]", "crossref": [ { "id": "27910", "database": "ChEBI", "url": "" }, { "id": "C05107", "database": "COMPOUND", "url": "" }, { "id": "ZINC000004096611", "database": "ZINC", "url": "" }, { "id": "HMDB0003896", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-196420", "participant_name": "DESMOL [endoplasmic reticulum membrane]", "crossref": [ { "id": "17737", "database": "ChEBI", "url": "" }, { "id": "2748", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "HMDB0002719", "database": "HMDB Metabolite", "url": "" }, { "id": "ZINC000003876073", "database": "ZINC", "url": "" }, { "id": "C01802", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-6807057", "participant_name": "7-dehydroCHOL [endoplasmic reticulum membrane]", "crossref": [ { "id": "17759", "database": "ChEBI", "url": "" }, { "id": "C01164", "database": "COMPOUND", "url": "" }, { "id": "ZINC000003860325", "database": "ZINC", "url": "" }, { "id": "HMDB0000032", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q5E9J5", "gene_name": "DHCR7", "activity": [ { "ec_number": "1.3.1.21", "activity": "cholesterol + NADP(+) = 7-dehydrocholesterol + NADPH + H(+).", "evidence": [ { "id": "Q5E9J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5" } ] }, { "ec_number": "3.3.2.11", "activity": "5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol.", "evidence": [ { "id": "Q5E9J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5" } ] }, { "ec_number": "1.3.1.21", "activity": "", "evidence": [ { "id": "Q5E9J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J5" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9J5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 475, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9J5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9J5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.3.1.21", "ec_name": "cholesterol + NADP(+) = 7-dehydrocholesterol + NADPH + H(+).", "evidence": [ { "id": "1.3.1.21", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.21" }, { "id": "1.3.1.21", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.3.1.21" } ] }, { "ec_number": "3.3.2.11", "ec_name": "5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol.", "evidence": [ { "id": "3.3.2.11", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.11" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 14 ], "sequon_annotation_sites": [ { "start_pos": 252, "end_pos": 254 }, { "start_pos": 287, "end_pos": 289 }, { "start_pos": 407, "end_pos": 409 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9K2-1", "uniprot_ac": "Q5E9K2", "uniprot_id": "MED22_BOVIN", "mass": { "chemical_mass": 22381.0, "monoisotopic_mass": 22381.0 }, "refseq": { "ac": "NP_001029914", "name": "mediator of RNA polymerase II transcription subunit 22", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029914" }, "gene_names": [ { "name": "MED22", "type": "recommended", "evidence": [ { "id": "Q5E9K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9K2" } ] }, { "name": "MED22", "type": "synonym", "evidence": [ { "id": "NP_001029914", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029914" } ] }, { "name": "SURF5", "type": "synonym", "evidence": [ { "id": "NP_001029914", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029914" }, { "id": "Q5E9K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9K2" } ] } ], "protein_names": [ { "name": "Mediator of RNA polymerase II transcription subunit 22", "type": "recommended", "evidence": [ { "id": "Q5E9K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9K2/entry#names_and_taxonomy" } ] }, { "name": "Mediator complex subunit 22", "type": "synonym", "evidence": [ { "id": "Q5E9K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9K2/entry#names_and_taxonomy" } ] }, { "name": "Surfeit locus protein 5", "type": "synonym", "evidence": [ { "id": "Q5E9K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9K2/entry#names_and_taxonomy" } ] }, { "name": "mediator of RNA polymerase II transcription subunit 22", "type": "synonym", "evidence": [ { "id": "NP_001029914", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029914" } ] }, { "name": "surfeit 5", "type": "synonym", "evidence": [ { "id": "NP_001029914", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029914" } ] }, { "name": "surfeit locus protein 5", "type": "synonym", "evidence": [ { "id": "NP_001029914", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029914" } ] } ], "function": [ { "annotation": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9K2", "url": "https://www.uniprot.org/uniprotkb/Q5E9K2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9K2", "url": "https://www.uniprot.org/uniprotkb/Q5E9K2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MED22", "url": "https://www.uniprot.org/uniprotkb/Q5E9K2", "locus": { "chromosome": "11", "start_pos": 104249113, "end_pos": 104255141, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011556", "url": "https://www.ensembl.org/id/ENSBTAG00000011556" } ] } } ], "crossref": [ { "id": "Q5E9K2", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9K2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011556", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011556", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613736", "url": "https://www.ncbi.nlm.nih.gov/gene/613736", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613736", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613736", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KQAECDQ", "url": "https://omabrowser.org/oma/group/KQAECDQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9K2", "url": "https://www.orthodb.org/?gene=Q5E9K2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12434", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12434", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12434:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12434:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06179", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06179", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029914", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029914", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9K2", "url": "https://www.uniprot.org/uniprotkb/Q5E9K2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9K2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9K2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9K2-2", "url": "https://www.uniprot.org/uniprotkb/Q5E9K2-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQQRALPQSKETLLQSYNKRLKDDVKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRALQEECDRKLIALRDEVSIDLYELEEEYYSSSSSLCEANDLPLCEAYWRLDPDTDSTDCLSAPLLASPEPSAGGPLQAAAPTHSHAGGPGPTEHA", "length": 201, "header": "sp|Q5E9K2-1|MED22_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 22 OS=Bos taurus OX=9913 GN=MED22 PE=2 SV=1 CANONICAL=Q5E9K2-1" }, "isoforms": [ { "isoform_ac": "Q5E9K2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9K2/entry#Q5E9K2-1", "sequence": { "sequence": "MAQQRALPQSKETLLQSYNKRLKDDVKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRALQEECDRKLIALRDEVSIDLYELEEEYYSSSSSLCEANDLPLCEAYWRLDPDTDSTDCLSAPLLASPEPSAGGPLQAAAPTHSHAGGPGPTEHA", "length": 201, "header": "sp|Q5E9K2-1|MED22_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 22 OS=Bos taurus OX=9913 GN=MED22 PE=2 SV=1 CANONICAL=Q5E9K2-1" }, "locus": {} }, { "isoform_ac": "Q5E9K2-2", "url": "https://www.uniprot.org/uniprotkb/Q5E9K2/entry#Q5E9K2-2", "sequence": { "sequence": "MAQQRALPQSKETLLQSYNKRLKDDVKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRALQEECDRKLIALRDEVSIDLYELEEEYYSSRYK", "length": 140, "header": "sp|Q5E9K2-2|MED22_BOVIN Isoform 2 of Mediator of RNA polymerase II transcription subunit 22 OS=Bos taurus OX=9913 GN=MED22 PE=2 SV=1 CANONICAL=Q5E9K2-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 198, "start_aa": "Thr", "end_pos": 198, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr198", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9K2", "url": "https://www.uniprot.org/uniprotkb/Q5E9K2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:613736", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613736", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480S722-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 22", "gene_name": "MED22", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAQQRALPQSKETLLQSYNKRLKDDVKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAVDQRNQQLRALQEECDRKLIALRDEVSIDLYELEEEYYSSSSSLCEANDLPLCEAYWRLDLDTDSADGLSAPPLMSPEPSAGPLQAAAPAHTHTGGPGPTEHS", "length": 200 }, "evidence": [ { "id": "Q5E9K2", "url": "https://omabrowser.org/oma/group/Q5E9K2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MQ40-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 22", "gene_name": "Med22", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRALQEECDRKLITLRDEVSIDLYELEEEYYSSSSSLCEANDLPLCEAYWRLDLDTDSADGLSAPLLASPETGAGPLQSAASAHSHGGGPGPIEHT", "length": 200 }, "evidence": [ { "id": "Q5E9K2", "url": "https://omabrowser.org/oma/group/Q5E9K2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0JPN6-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 22", "gene_name": "Med22", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRALQEECDRKLITLRDEVSIDLYELEEEYYSSSSSLCEANDLPLCEAYWRLDLDTDSADGLSAPLLASPETGAGPLQSAAPVHSHGGGPGPTEHT", "length": 200 }, "evidence": [ { "id": "Q5E9K2", "url": "https://omabrowser.org/oma/group/Q5E9K2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q15528-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 22", "gene_name": "MED22", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRTLQEECDRKLITLRDEISIDLYELEEEYYSSSSSLCEANDLPLCEAYGRLDLDTDSADGLSAPLLASPEPSAGPLQVAAPAHSHAGGPGPTEHA", "length": 200 }, "evidence": [ { "id": "Q5E9K2", "url": "https://omabrowser.org/oma/group/Q5E9K2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54XB0-1", "protein_name": "Putative mediator of RNA polymerase II transcription subunit 22", "gene_name": "med22", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNTGGNNSLPPQTRGEVLFRDQQFFQKQIDSKIMQLLENYHNIIKISKVNDPLKNASEIYEMETRTSNMLNAGEGLLKIIEELKQNLILNDFSTMAEEVRIQNLVFHKENERTNKSIKLISEELSRSLKELEDEYYNSSYKLPPPSSSK", "length": 149 }, "evidence": [ { "id": "Q5E9K2", "url": "https://omabrowser.org/oma/group/Q5E9K2/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q62276-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 22", "gene_name": "Med22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRALQEECDRKLITLRDEVSIDLYELEEEYYSSSSSLCEANDLPLCEAYWRLDLDADSADGLSAPLLASPETGAGPLQSAAPVHSHGGGPGPTEHT", "length": 200 }, "evidence": [ { "id": "Q5E9K2", "url": "https://omabrowser.org/oma/group/Q5E9K2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q800L3-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 22", "gene_name": "MED22", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAQQRVLPQSKETLLQSYNKRLKDDVKSIMDNFTEIIKTAKIEDETQVSRATQSEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAINQRNQQLRSLQEECDKKLIALRDEISIDLYELEEEYYSSSYSLCDSNDLPLCEAYWREDFDMPSPESLSMPLTTATAEQSIATSQSSTPSHPHVNGHGAGPTDHS", "length": 203 }, "evidence": [ { "id": "Q5E9K2", "url": "https://omabrowser.org/oma/group/Q5E9K2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9SA42-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 22a", "gene_name": "MED22A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MMNKGGGSGGGSGPTAAAAAAALQKQKALLQRVDTDITSVVDNFNQIVNVARVSDPPMKNSQEAYMMEMRASRLVQAADSLLKLVSELKQTAIFSGFASLNDHVEQRIAEFDQEAEKTNRLLARIADDASASLKELESHYYSSAQRSTLD", "length": 150 }, "evidence": [ { "id": "Q5E9K2", "url": "https://omabrowser.org/oma/group/Q5E9K2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9V439-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 22", "gene_name": "MED22", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MASGSRTTILPQSKEALLKSYNARLKDDVRSMLENFEEILKLARRESHSQISKTTQCEQDALEMQVRAANMVRAGESLMKLVADLKQYLILNDFHSVNEAITNNSQLFRNTQSECDKKLMKLRDEMAMDLYDLEEEYYTSIFK", "length": 143 }, "evidence": [ { "id": "Q5E9K2", "url": "https://omabrowser.org/oma/group/Q5E9K2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q5E9K2", "url": "https://www.uniprot.org/uniprotkb/Q5E9K2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q5E9K2", "url": "https://www.uniprot.org/uniprotkb/Q5E9K2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "Q5E9K2", "url": "https://www.uniprot.org/uniprotkb/Q5E9K2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mediator complex", "id": "GO:0016592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "evidence": [ { "database": "UniProtKB", "id": "Q5E9K2", "url": "https://www.uniprot.org/uniprotkb/Q5E9K2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 32, "end_pos": 34, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9K2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 201, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": 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"MNWRFVELLYFLFVWGRISVQPSHQEPAATDQHVSKEFDWLISDRGPFHHSRSYLSFVERHRQGFTTRYKIYREFARWKVRNTAIERRDLVRHPVPLMPEFQRSIRLLGRRPTTQQFIDTVIKKYGTHLLISATLGGEEALTMYMDKSRLDRKSGNATQSVEALHQLASSYFVDRDGTMRRLHEIQISTGAIKVTETRTGPLGCNSYDNLDSVSSVLLQSTESKLHLQGLQIIFPQYLQEKFVQSALSYIMCNGEGEYVCQNSQCRCQCAEEFPQCNCPITDIQIMEYTLASMAKSWAEAYKDLENSDEFKSFMKRLPSNHFLTIGSIHQHWGNDWDLQNRYKLLQSAMEAQRQKIQRTARKLFGLSVRCRHNPNHQLPRERTIQQWLARVQSLLYCNENGFWGTFLESQRSCVCHGSTTLCQRPIPCIIGGNNSCAMCSLANISLCGSCNKGYKLYRGRCEPQNVDSERSEQFISFETDLDFQDLELKYLLQKMDSRLYVHTTFISNEIRLDTFFDPRWRKRLSLTLKSNKNRMDFIHMVIGMSMRICQMRNSSLDPMFFVYINPFSGSHSEGWNMPFGEFGYPRWEKIRLQNSQCYNWTLLLGNRWKTFFETVHIYLRSRTRLPTLLRNETGQGPVDLSDPSKRQFYIKISDVQVFGYSLRFNADLLRSAVQQVNQSYTQGGQFYSSSSVMLLLLDIRDRINRLAPPVAPGKPQLDLFSCMLKHRLKLTNSEIIRVNHALDLYNTEILKQSDQMTAKLC", "length": 761, "header": "sp|Q5E9L2-1|BRNP1_BOVIN Isoform 1 of BMP/retinoic acid-inducible neural-specific protein 1 OS=Bos taurus OX=9913 GN=BRINP1 PE=2 SV=1 CANONICAL=Q5E9L2-1" }, "isoforms": [ { "isoform_ac": "Q5E9L2-1", "url": 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PE=2 SV=1 CANONICAL=Q5E9L2-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 156, "start_aa": "Asn", "end_pos": 156, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn156", "evidence": [ { "id": "Q5E9L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L2#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 433, "start_aa": "Asn", "end_pos": 433, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn433", "evidence": [ { "id": "Q5E9L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L2#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 443, "start_aa": "Asn", "end_pos": 443, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn443", "evidence": [ { "id": "Q5E9L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L2#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 553, "start_aa": "Asn", "end_pos": 553, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn553", "evidence": [ { "id": "Q5E9L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L2#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 599, "start_aa": "Asn", "end_pos": 599, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn599", "evidence": [ { "id": "Q5E9L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L2#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 631, "start_aa": "Asn", "end_pos": 631, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn631", "evidence": [ { "id": "Q5E9L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L2#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 677, "start_aa": "Asn", "end_pos": 677, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn677", "evidence": [ { "id": "Q5E9L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L2#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9L2", "url": "https://www.uniprot.org/uniprotkb/Q5E9L2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:538990", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538990", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5E9L2", "url": "https://www.uniprot.org/uniprotkb/Q5E9L2" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "Q5E9L2", "url": "https://www.uniprot.org/uniprotkb/Q5E9L2" } ], "pmid": "" }, { "name": "neuronal cell body", "id": 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"reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9L2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 761, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9L2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9L2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 156, 433, 443, 553, 599, 631, 677 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 156, "end_pos": 158 }, { "start_pos": 433, "end_pos": 435 }, { "start_pos": 443, "end_pos": 445 }, { "start_pos": 553, "end_pos": 555 }, { "start_pos": 599, "end_pos": 601 }, { "start_pos": 631, "end_pos": 633 }, { "start_pos": 677, "end_pos": 679 } ] }, 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0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 7 }, { "field": "exact_n_linked_sites", "count": 7 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9L7-1", "uniprot_ac": "Q5E9L7", "uniprot_id": "VPS16_BOVIN", "mass": { "chemical_mass": 94813.0, "monoisotopic_mass": 94813.0 }, "refseq": {}, "gene_names": [ { "name": "VPS16", "type": "recommended", "evidence": [ { "id": "Q5E9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L7" } ] } ], "protein_names": [ { "name": "Vacuolar protein sorting-associated protein 16 homolog", "type": "recommended", "evidence": [ { "id": "Q5E9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for recruitment of VPS33A to the HOPS complex. Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS33A but not VPS33B. The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9L7", "url": "https://www.uniprot.org/uniprotkb/Q5E9L7#function" }, { "database": "UniProtKB", "id": "Q9H269", "url": "https://www.uniprot.org/uniprotkb/Q9H269#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9L7", "url": "https://www.uniprot.org/uniprotkb/Q5E9L7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VPS16", "url": "https://www.uniprot.org/uniprotkb/Q5E9L7", "locus": { "chromosome": "13", "start_pos": 52319463, "end_pos": 52347540, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001320", "url": "https://www.ensembl.org/id/ENSBTAG00000001320" } ] } } ], "crossref": [ { "id": 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SV=1 CANONICAL=Q5E9L7-1" }, "isoforms": [ { "isoform_ac": "Q5E9L7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9L7/entry#Q5E9L7-1", "sequence": { "sequence": 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SV=1 CANONICAL=Q5E9L7-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 211, "start_aa": "Thr", "end_pos": 211, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr211", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": 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[ { "database": "UniProtKB", "id": "Q5E9L7", "url": "https://www.uniprot.org/uniprotkb/Q5E9L7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "vacuole fusion, non-autophagic", "id": "GO:0042144", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042144", "evidence": [ { "database": "UniProtKB", "id": "Q5E9L7", "url": "https://www.uniprot.org/uniprotkb/Q5E9L7" } ], "pmid": "" }, { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "Q5E9L7", "url": "https://www.uniprot.org/uniprotkb/Q5E9L7" } ], "pmid": "" }, { "name": "endosomal transport", "id": "GO:0016197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016197", "evidence": [ { "database": "UniProtKB", "id": "Q5E9L7", "url": "https://www.uniprot.org/uniprotkb/Q5E9L7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "Q5E9L7", "url": "https://www.uniprot.org/uniprotkb/Q5E9L7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 211 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { 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Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:352959", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:352959", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FWFAQKA", "url": "https://omabrowser.org/oma/group/FWFAQKA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9M9", "url": "https://www.orthodb.org/?gene=Q5E9M9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46819", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46819", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46819:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46819:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08355", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08355", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08356", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08356", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9013419", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013419", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_847886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_847886", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "64900", "url": "https://www.rhea-db.org/rhea/64900", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9M9", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9M9-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPARAEEITIPADVTPEKVPTHIVDYSETEQTVEELQGEIDKADVVCVVYDVSEEATVEKIRTKWIPLVNGDTKRGPRVPIILVGNKSDLRPGGSMEAVLPIMSQFPEIETCVECSAKNLKNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDMDQALSDQELNAFQTSCFGHPLAPQALEDVKMVVSKNVVGGVRDDQLTLDGFLFLNTLFIQRGRHETTWTILRRFGYGDSLELTADYLCPPLRVPPGCSAELNHRGYQFVQRMFEKHDQDRDGALSPAELQSLFSVFPAAPWGPHLPSTVRTKAGRLPLHGYLCQWTLVTYLDVRRSLEHLGYLGYPTLCEQDSQAHAITVTREKRLDQEKGQTQRNVLLCKVVGARGVGKSSFLRAFLGHSLGHQDAGEPSVYAIDTVQVNGQEKYLILCEVAADSLLTASADASCDVACLMFDGSDLRSFALCASVYKQHYMDGQTPCLFVCSKADLPGGVPLPGLSPAEFCRRHRLPTPTLFSCAGPVEPCMGIFTRLATMATFPHLVHGQLQATSFWLRVALGAMGAAVAAILSFSLYRVLVKSR", "length": 618, "header": "sp|Q5E9M9-1|MIRO2_BOVIN Isoform 1 of Mitochondrial Rho GTPase 2 OS=Bos taurus OX=9913 GN=RHOT2 PE=2 SV=1 CANONICAL=Q5E9M9-1" }, "isoforms": [ { "isoform_ac": "Q5E9M9-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9/entry#Q5E9M9-1", "sequence": { "sequence": "MKRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPARAEEITIPADVTPEKVPTHIVDYSETEQTVEELQGEIDKADVVCVVYDVSEEATVEKIRTKWIPLVNGDTKRGPRVPIILVGNKSDLRPGGSMEAVLPIMSQFPEIETCVECSAKNLKNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDMDQALSDQELNAFQTSCFGHPLAPQALEDVKMVVSKNVVGGVRDDQLTLDGFLFLNTLFIQRGRHETTWTILRRFGYGDSLELTADYLCPPLRVPPGCSAELNHRGYQFVQRMFEKHDQDRDGALSPAELQSLFSVFPAAPWGPHLPSTVRTKAGRLPLHGYLCQWTLVTYLDVRRSLEHLGYLGYPTLCEQDSQAHAITVTREKRLDQEKGQTQRNVLLCKVVGARGVGKSSFLRAFLGHSLGHQDAGEPSVYAIDTVQVNGQEKYLILCEVAADSLLTASADASCDVACLMFDGSDLRSFALCASVYKQHYMDGQTPCLFVCSKADLPGGVPLPGLSPAEFCRRHRLPTPTLFSCAGPVEPCMGIFTRLATMATFPHLVHGQLQATSFWLRVALGAMGAAVAAILSFSLYRVLVKSR", "length": 618, "header": "sp|Q5E9M9-1|MIRO2_BOVIN Isoform 1 of Mitochondrial Rho GTPase 2 OS=Bos taurus OX=9913 GN=RHOT2 PE=2 SV=1 CANONICAL=Q5E9M9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Cloning and characterization of the mouse Arht2 gene which encodes a putative atypical GTPase.", "journal": "Cytogenet. Genome Res.", "date": "2004", "authors": "Shan Y, Hexige S, Guo Z, Wan B, Chen K, Chen X, Ma L, Huang C, Zhao S, Yu L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M9", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ], "reference": [ { "type": "PubMed", "id": "15218247", "url": "https://glygen.org/publication/PubMed/15218247" } ] }, { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M9", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:352959", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:352959", "resource": "KEGG Pathway" }, { "id": "R-BTA-9013419", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013419", "resource": "Reactome", "description": "RHOT2 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z5P2-1", "protein_name": "Mitochondrial Rho GTPase", "gene_name": "RHOT2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKRDVRILLLGEAQVGKTSLIMALVGEEFPEEVPPRAEEITIPADVTPEKVPTHIVDYSESEQTEDELQEEIAKANVVCVVYDVTKEATIEKIRTKWIPMVNGGAEKGARIPIILVGNKSDLQMGSSMEVILPIMNQFSEIETCVECSAKNLKNISELFYYAQKAVLHPTAPLYDPEEKQLRPACSRALTRIFNLSDQDNNQILSDDELNYFQKSCFGNPLAPQALEDVKMVVWKNTTDGVQDSGLTLNGFLFLNTLFIQRGRHETTWTILRRFGYDDELELTDDYLYPQFRLPPGCSTELNHLGYQFLQRLFEKHDKDQDGALSPAELQNFFSVFPCMPWGPELYNTVCTTDKGLLSLHGFLCQWTLIAYLDVRHCLECLGYLGYPILSEQDSQTQALTVTREKRIDLEKGQTQRNVFLCKVLGARGAGKSAFLQAFLGRSLAAQRENPGEPSPYTINTVQVNGQEKYLILHEVSAETQFTKPSDAACDVACLIYDLSDPKSFSYCASIYKQHYMDSQIPCVFVASKTDLPEASQQPGLSPAEFCYKHCLPPPFLFSCHSQGPPGTAIYTKLATAATFPHLNAVELGAASFWLRVALGAAVTALVGFTLYRVLAKNK", "length": 618 }, "evidence": [ { "id": "Q5E9M9", "url": "https://omabrowser.org/oma/group/Q5E9M9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F4J0W4-1", "protein_name": "Mitochondrial Rho GTPase 2", "gene_name": "MIRO2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MMLGGKSSAGGRTSLRVAVAGDKGTGKSSLISAVASETFPDNVPRVLPPITLPADAFPDYIPITIVDTPSSIDNRIKLIEEFRKADVVLLTYACDQPSTLDRLSSYWLPELRRLEIKAPVIVVGCKLDLRDERSPARLEDIMSPIMKEYREIETCIECSALTLIQVPDVFYFASKAVLHPTFPLFDQEKQCLKPRLRRAVQRIFNLCDHDLDGALNDAELNDFQVNCFGAPLDPVELMGVKKVVQERQPDGVTDLGLTLPGFLFLFSLFIERGRPETAWAILRKCGYNDSLELHAELLPVPAKQSPDQSIELTNEAMDFLSGIFQLYDLDNDGALQPAELDDLFQTAPDSPWLEDPYKEAAEKTPGGSLTINGFLSEWALMTLLDPRKSLANLTYIGYGHDPASTFSVTRKRSVDRKKQRTERNVFQCFVFGPKKSGKSALLDSFLGRKFSNSYKATMGERYAANVIDQPGGSKKTLILREIPEDRVKKFLTNKESLAACDVAVVVYDSSDVYSWRKAREILMEVARRGEERGYGTPCLLVAAKDDLDPYPMSVQESDRVCMELGIDIPVSLSMKLGEPNSLFSRIVSTAENPHMSIPETESGRRSRNIRQLVNSSLLFVSVGTAVGFAGLAAYRAYSARKNA", "length": 643 }, "evidence": [ { "id": "Q5E9M9", "url": "https://omabrowser.org/oma/group/Q5E9M9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q32LU1-1", "protein_name": "Mitochondrial Rho GTPase 2", "gene_name": "rhot2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKRDVRILLLGEPKVGKTSLIMSLVGEEFPEQVPLRAEEITIPADVTPEKVPTHIVDYSENEQTDEVLREEIVKANVVCVVYDVTQEETIDKIRTKWIPLVNGGAEKGSKIPIILVGNKSDLRSGSSMETILPIMNQFSEIETCVECSAKNLKNISELFYYAQKAVLHPTAPLYDPEDKQLKAQCVRALSRIFSISDQDNDHILSDAELNCFQKLCFGNPLAPQALEDVKTVVWKNTSDGVQDNGLTLNGFLFLNTLFIQRGRHETTWTILRKFGYDDTLELTDDYLYPVLRVSVGCTTELNHLGHQFLLKLFEKYDEDKDSALSPAELKNLFSVLPYMPWSSTVYSNIPLTDDCYISQHGYLCQWMLLAYLDVHRCLEHLGYLGYPILMEQECQTSAITVTREKALDLDNRQTQRTVFLCKVIGPRGTGKTDFLRAFLQRSTERSDRDPGAPSIYAINTVSIANQDKYLILEEVDVETEFLKAADAACDVACLMYDVSDPDSFNYCASIYKQHYMDSGIPCVVLGSKADLVEVKQHHGMSPSEFCYKHRLPSPLHFSALLTHTHTHIYSKLTWAAMYPHLNGSDMSSTSFWLRVTLGATIAAMLGFALYRAFSRHK", "length": 617 }, "evidence": [ { "id": "Q5E9M9", "url": "https://omabrowser.org/oma/group/Q5E9M9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q7TSA0-1", "protein_name": "Mitochondrial Rho GTPase 2", "gene_name": "Rhot2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPARAEEITIPADVTPEKVPTHIVDYSEAEQTEEELQEEIHKANVVCVVYDVSEEATIEKIRTKWIPLVNGRTATGPRLPIILVGNKSDLRPGSTIEAVLPIMSQFPEIETCVECSAKHLRNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDLDHALSDKELNAFQKSCFGHPLAPQALEDVKRVVCKNVAGGVQDDRLTLEGFLFLNTLFIQRGRHETTWTILRRFGYSDSLELTPDYLCPPLYVPPGCSTELNHRGYQFVQRVFEKHDQDHDGVLSPTELESLFSVFSVAPWGPELLHTVPTEAGCLSLRGYLCQWTLVTYLDVQHCLAHLGYLGYPTLCEQDSQAQAITVTREKRLDQEKGQTQRSVLMCKVLGARGVGKSAFLQAFLGHSLGEARDRDAPEKLPTHTINTVRVSGQEKYLILCEVNADSLLDTSLDTTCDVACLMFDSSDPETFVQCATIYKRYYMDGQTPCLFISSKADLPEGVAPPGLSPAEFCRRHRLPAPASFSCLGPAQSSIDVFTQLATMATFPHLAHTELHPTPFWLRGVLVAVGTAVAAVLSFSLYRVLVKSR", "length": 622 }, "evidence": [ { "id": "Q5E9M9", "url": "https://omabrowser.org/oma/group/Q5E9M9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8IXI1-1", "protein_name": "Mitochondrial Rho GTPase 2", "gene_name": "RHOT2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPPRAEEITIPADVTPEKVPTHIVDYSEAEQTDEELREEIHKANVVCVVYDVSEEATIEKIRTKWIPLVNGGTTQGPRVPIILVGNKSDLRSGSSMEAVLPIMSQFPEIETCVECSAKNLRNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDLDQALSDEELNAFQKSCFGHPLAPQALEDVKTVVCRNVAGGVREDRLTLDGFLFLNTLFIQRGRHETTWTILRRFGYSDALELTADYLSPLIHVPPGCSTELNHLGYQFVQRVFEKHDQDRDGALSPVELQSLFSVFPAAPWGPELPRTVRTEAGRLPLHGYLCQWTLVTYLDVRSCLGHLGYLGYPTLCEQDQAHAITVTREKRLDQEKGQTQRSVLLCKVVGARGVGKSAFLQAFLGRGLGHQDTREQPPGYAIDTVQVNGQEKYLILCEVGTDGLLATSLDATCDVACLMFDGSDPKSFAHCASVYKHHYMDGQTPCLFVSSKADLPEGVAVSGPSPAEFCRKHRLPAPVPFSCAGPAEPSTTIFTQLATMAAFPHLVHAELHPSSFWLRGLLGVVGAAVAAVLSFSLYRVLVKSQ", "length": 618 }, "evidence": [ { "id": "Q5E9M9", "url": "https://omabrowser.org/oma/group/Q5E9M9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8JZN7-1", "protein_name": "Mitochondrial Rho GTPase 2", "gene_name": "Rhot2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPARAEEITIPADVTPEKVPTHIVDYSEAEQTEEELQEEIHKANVVCVVYDVSEETTIEKIRTKWIPLVNGRTATGPRLPIILVGNKSDLRPGSTMEAVLPIMSQFPEIETCVECSAKHLRNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDRDHGLSDEELNAFQKSCFGHPLAPQALEDVKRVVCKNVSGGVQNDRLTLEGFLFLNTLFIQRGRHETTWTILRRFGYSDSLELTPDYLYPALHVPPGCSTELNHRGYQFVQRMFEKHDQDHDGVLSPTELQNLFSVFSGAPWGPELLHTVPTQAGCLPLHGYLCQWTLMTYLDVQQCLAHLGYLGYPTLCEQDSQAQAITVTREKKLDQEKGQTQRSVLMCKVLGARGVGKSAFLQAFLGNSLGEARDPPEKFPLHTINTVRVNGQEKYLILCEVNADSLLDTSLDTTCDVACLMFDSSDPKTFVHCATIYKRYYMDGQTPCLFIASKADLPEGVAPPGLSPAEFCRRHRLPAPASFSCLGPAMPSTDVFTQLATMATFPHLVHTELHPTSFWLRGVLVAVGTAVAAVLSFSLYRVLVKSR", "length": 620 }, "evidence": [ { "id": "Q5E9M9", "url": "https://omabrowser.org/oma/group/Q5E9M9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "mitochondrion transport along microtubule", "id": "GO:0047497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047497", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M9", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ], "pmid": "" }, { "name": "cellular homeostasis", "id": "GO:0019725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019725", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M9", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ], "pmid": "" }, { "name": "mitochondrion organization", "id": "GO:0007005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007005", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M9", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ], "pmid": "" }, { "name": "mitochondrial outer membrane permeabilization", "id": "GO:0097345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097345", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M9", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M9", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ], "pmid": "" }, { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M9", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M9", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M9", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M9", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ], "pmid": "" }, { "name": "GDP binding", "id": "GO:0019003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019003", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M9", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "Q5E9M9", "url": "https://www.uniprot.org/uniprotkb/Q5E9M9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 118, "end_pos": 120, "annotation": "n_glycosylation_sequon" }, { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] }, { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] }, { "id": "64900", "name": "", "equation": "UTP + H2O = UDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MB25-1", "O18956-1", "Q2HJF8-1", "Q5E9M9-1", "A0JND9-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "G3MZH7-1", "A0AAF6YME1-1" ], "evidence": [ { "id": "64900", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/64900" } ] }, { "id": "R-BTA-9018824", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, mitochondrial outer membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9M9-1" ], "evidence": [ { "id": "R-BTA-9018824", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9018824" } ] }, { "id": "R-BTA-9018826", "name": "RHOT2 hydrolyzes GTP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, mitochondrial outer membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9M9-1" ], "evidence": [ { "id": "R-BTA-9018826", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9018826" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BJA0", "gene_name": "RAB33A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "E1BJA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJA0" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MHP4", "gene_name": "RAB22A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MHP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHP4" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MM29", "gene_name": "RASL11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MM29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM29" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNI4", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MNI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI4" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MX39", "gene_name": "RAB42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1MX39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX39" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2J9", "gene_name": "RAB8B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N2J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2J9" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F1N6Y7", "gene_name": "EIF5B", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "F1N6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6Y7" } ] } ] }, { "uniprot_ac": "F1N7V2", "gene_name": "RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "F6Q1G9", "gene_name": "RAB24", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q1G9" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MYK6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3MYK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYK6" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N1U2", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N1U2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "G3N1U2", "database": "UniProtKB", "url": 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"VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P04695", "gene_name": "GNAT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04695" } ] } ] }, { "uniprot_ac": "P04896", "gene_name": "GNAS", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04896" } ] } ] }, { "uniprot_ac": "P08239", "gene_name": "GNAO1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P08239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08239" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] 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"id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00431", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00431", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015591", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9P5", "url": "https://www.uniprot.org/uniprotkb/Q5E9P5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9P5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9P5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELGWWPQLGLAFLQLLLISSLPREYTVINEACPGAEWNIMCRECCEYDQIKCECPGKKEVVGYTIPCCRNEENECDSCLIHPGCTIFENCKTCRNGSWGGTLDDFYVKGIYCAECRAGWYGGDCMRCGQVLRVPKGQILLESYPLNAHCEWTIHAKPGFIIQLRIVMLSLEFDYMCQYDYVEVRDGDSSDSQIIKRFCGNERPAPIRSTGSSLHILFHSDGSKNFDGFHAIFEEITACSSSPCFHDGTCLLDSTGSYKCACLAGYTGKHCENLLEERNCSDPGGPVNGYKKITGGPGLIHGHYAKIGTVLTFFCNSSYVLSGNEMRTCQQNGEWSGKQPICIKACREPKISDLVRRKVLPMQVQSRETPLHQLYSSAFSKQKLQDAPTKKPVLPFGDLPPGYQHLHTQLQYECISPFYRRLGSSRRTCLRTGKWSGRAPSCIPICGKTENVSAPKTQGTRWPWQAAIYRRAGGVHGGGLHKDAWFLVCSGALVNERTVVVAAHCVTDLGRVTVIKTADLKVVLGKFYRDDDRDEKSIQSLRISAIILHPNYDPILLDMDIAILKLLDKARMSTRVQPICLAAPRDLSTSFQESRITVAGWNVLADSRSPGYKDDMLRSGVVRVADSLLCEEQHEAQGIPVSVTDSMFCAGRDPTAPSDICTAETGGIAAVSFPGRASPEPRWHLVGLVSWSYDKTCSHSLSTAFTKVLPFKDWIERNMK", "length": 720, "header": "sp|Q5E9P5-1|PAMR1_BOVIN Isoform 1 of Inactive serine protease PAMR1 OS=Bos taurus OX=9913 GN=PAMR1 PE=2 SV=1 CANONICAL=Q5E9P5-1" }, "isoforms": [ { "isoform_ac": "Q5E9P5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9P5/entry#Q5E9P5-1", "sequence": { "sequence": "MELGWWPQLGLAFLQLLLISSLPREYTVINEACPGAEWNIMCRECCEYDQIKCECPGKKEVVGYTIPCCRNEENECDSCLIHPGCTIFENCKTCRNGSWGGTLDDFYVKGIYCAECRAGWYGGDCMRCGQVLRVPKGQILLESYPLNAHCEWTIHAKPGFIIQLRIVMLSLEFDYMCQYDYVEVRDGDSSDSQIIKRFCGNERPAPIRSTGSSLHILFHSDGSKNFDGFHAIFEEITACSSSPCFHDGTCLLDSTGSYKCACLAGYTGKHCENLLEERNCSDPGGPVNGYKKITGGPGLIHGHYAKIGTVLTFFCNSSYVLSGNEMRTCQQNGEWSGKQPICIKACREPKISDLVRRKVLPMQVQSRETPLHQLYSSAFSKQKLQDAPTKKPVLPFGDLPPGYQHLHTQLQYECISPFYRRLGSSRRTCLRTGKWSGRAPSCIPICGKTENVSAPKTQGTRWPWQAAIYRRAGGVHGGGLHKDAWFLVCSGALVNERTVVVAAHCVTDLGRVTVIKTADLKVVLGKFYRDDDRDEKSIQSLRISAIILHPNYDPILLDMDIAILKLLDKARMSTRVQPICLAAPRDLSTSFQESRITVAGWNVLADSRSPGYKDDMLRSGVVRVADSLLCEEQHEAQGIPVSVTDSMFCAGRDPTAPSDICTAETGGIAAVSFPGRASPEPRWHLVGLVSWSYDKTCSHSLSTAFTKVLPFKDWIERNMK", "length": 720, "header": "sp|Q5E9P5-1|PAMR1_BOVIN Isoform 1 of Inactive serine protease PAMR1 OS=Bos taurus OX=9913 GN=PAMR1 PE=2 SV=1 CANONICAL=Q5E9P5-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 451, "start_aa": "Asn", "end_pos": 451, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn451", "evidence": [ { "id": "Q5E9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9P5#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9P5", "url": "https://www.uniprot.org/uniprotkb/Q5E9P5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:513841", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513841", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q5E9P5", "url": "https://www.uniprot.org/uniprotkb/Q5E9P5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q5E9P5", "url": "https://www.uniprot.org/uniprotkb/Q5E9P5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 279, "end_pos": 281, "annotation": "n_glycosylation_sequon" }, { "start_pos": 316, "end_pos": 318, "annotation": "n_glycosylation_sequon" }, { "start_pos": 451, "end_pos": 453, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9P5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 720, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9P5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9P5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5E9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9P5" }, { "id": "PRU00059", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00059" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CUB", "eco_id": "ECO_0000255", "start_pos": 128, "end_pos": 236, "start_aa": "Cys", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5E9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9P5" }, { "id": "PRU00076", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00076" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000255", "start_pos": 235, "end_pos": 272, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5E9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9P5" }, { "id": "PRU00274", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00274" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000255", "start_pos": 445, "end_pos": 720, "start_aa": "Ile", "end_aa": "Lys", "glycosite_overlap": "Asn451" }, { "evidence": [ { "id": "Q5E9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9P5" }, { "id": "PRU00302", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00302" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sushi 1", "eco_id": "ECO_0000255", "start_pos": 278, "end_pos": 344, "start_aa": "Arg", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5E9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9P5" }, { "id": "PRU00302", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00302" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sushi 2", "eco_id": "ECO_0000255", "start_pos": 387, "end_pos": 444, "start_aa": "Ala", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 451 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 279, "end_pos": 281 }, { "start_pos": 316, "end_pos": 318 }, { "start_pos": 451, "end_pos": 453 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9P6-1", "uniprot_ac": "Q5E9P6", "uniprot_id": "BSCL2_BOVIN", "mass": { "chemical_mass": 44016.0, "monoisotopic_mass": 44016.0 }, "refseq": { "ac": "NP_001015589", "name": "seipin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015589" }, "gene_names": [ { "name": "BSCL2", "type": "recommended", "evidence": [ { "id": "Q5E9P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9P6" } ] }, { "name": "BSCL2", "type": "synonym", "evidence": [ { "id": "NP_001015589", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015589" } ] } ], "protein_names": [ { "name": "Seipin", "type": "recommended", "evidence": [ { "id": "Q5E9P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9P6/entry#names_and_taxonomy" } ] }, { "name": "BSCL2, seipin lipid droplet biogenesis associated", "type": "synonym", "evidence": [ { "id": "NP_001015589", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015589" } ] }, { "name": "Bernardinelli-Seip congenital lipodystrophy 2 (seipin)", "type": "synonym", "evidence": [ { "id": "NP_001015589", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015589" } ] }, { "name": "Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog", "type": "synonym", "evidence": [ { "id": "Q5E9P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9P6/entry#names_and_taxonomy" } ] }, { "name": "bernardinelli-Seip congenital lipodystrophy type 2 protein homolog", "type": "synonym", "evidence": [ { "id": "NP_001015589", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015589" } ] }, { "name": "seipin", "type": "synonym", "evidence": [ { "id": "NP_001015589", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015589" } ] } ], "function": [ { "annotation": "Mediates the formation of lipid droplets during the differentiation and maturation of adipocytes (By similarity). Together with LDAF1, defines the sites of lipid droplet formation in the endoplasmic reticulum and promotes the aggregation of triacylglycerol molecules to form the core of a lipid droplet (nucleation) in the endoplasmic reticulum and drive budding of lipid droplets into the cytoplasm (By similarity). BSCL2 and LDAF1 also regulate protein and lipid delivery from the endoplasmic reticulum into growing lipid droplets: during early adipogenesis, BSCL2 inhibits GPAT3 and GPAT4 activity, thereby preventing phosphatidic acid accumulation that could antagonize PPARG and block differentiation. This inhibition is then relieved by ADIG during adipocyte maturation, allowing expansion of lipid droplets (By similarity). Regulates the maturation of ZFYVE1-positive nascent lipid droplets and the function of the RAB18-ZFYVE1 complex in mediating the formation of endoplasmic reticulum-lipid droplet contacts. Binds anionic phospholipids including phosphatidic acid (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9P6", "url": "https://www.uniprot.org/uniprotkb/Q5E9P6#function" }, { "database": "UniProtKB", "id": "Q96G97", "url": "https://www.uniprot.org/uniprotkb/Q96G97#function" }, { "database": "UniProtKB", "id": "Q9Z2E9", "url": "https://www.uniprot.org/uniprotkb/Q9Z2E9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9P6", "url": "https://www.uniprot.org/uniprotkb/Q5E9P6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BSCL2", "url": "https://www.uniprot.org/uniprotkb/Q5E9P6", "locus": { "chromosome": "29", "start_pos": 41015970, "end_pos": 41027363, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002503", "url": "https://www.ensembl.org/id/ENSBTAG00000002503" } ] } } ], "crossref": [ { "id": "Q5E9P6", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9P6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd23993", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23993", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513558", "url": "https://www.ncbi.nlm.nih.gov/gene/513558", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009617", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009617", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513558", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513558", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9P6", "url": "https://www.orthodb.org/?gene=Q5E9P6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21212", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21212", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21212:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21212:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06775", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06775", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015589", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9P6", "url": "https://www.uniprot.org/uniprotkb/Q5E9P6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9P6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9P6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVNDPPVPALLWAQEMGHVMAGRARKLLLQFGVFFCTILLLLWVSVFLYGSFYYSYMPTVSHLSPVHFHYRTDCESSTSLLCSFPVANVTLAKGGRDRVLMYGQPYRVTLELELPESPVNQDLGMFLVTISCYTRGGRIISTSSRSVMLHYRSSLLQMLDTLVFSSLLLFGFAEQKQLLEVELYPEYRENSYVPTTGAIIEIHSKRIQMYGAYLRIHAHFTGLRYLLYNFPMTCAFVGVASNFTFLSVIVLFSYMQWVWGGIWPRQRLSLQVNIRNRKRSRKDIQRKVSAHQPGPQGQEESPQLSPVTEDGESHADPSGTEGQLSEEEKTEQQPLSGEEELEPEASDGSGSWEDAALLTEANLAASGSAPAPETVGSSEPSAGSVRQRPICSSS", "length": 394, "header": "sp|Q5E9P6-1|BSCL2_BOVIN Isoform 1 of Seipin OS=Bos taurus OX=9913 GN=BSCL2 PE=2 SV=1 CANONICAL=Q5E9P6-1" }, "isoforms": [ { "isoform_ac": "Q5E9P6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9P6/entry#Q5E9P6-1", "sequence": { "sequence": 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"method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9R0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9R0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 258 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 28 ], "sequon_annotation_sites": [ { "start_pos": 341, "end_pos": 343 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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}, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9R1-1", "uniprot_ac": "Q5E9R1", "uniprot_id": "S52A3_BOVIN", "mass": { "chemical_mass": 50530.0, "monoisotopic_mass": 50530.0 }, "refseq": { "ac": "NP_001014864", "name": "solute carrier family 52, riboflavin transporter, member 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014864" }, "gene_names": [ { "name": "SLC52A3", "type": "recommended", "evidence": [ { "id": "Q5E9R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1" } ] }, { "name": "C13H20orf54", "type": "synonym", "evidence": [ { "id": "NP_001014864", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014864" } ] }, { "name": "C20orf54", "type": "synonym", "evidence": [ { "id": "NP_001014864", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014864" } ] }, { "name": "RFT2", "type": "synonym", "evidence": [ { "id": "NP_001014864", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014864" }, { "id": "Q5E9R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1" } ] }, { "name": "SLC52A3", "type": "synonym", "evidence": [ { "id": "NP_001014864", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014864" } ] } ], "protein_names": [ { "name": "Solute carrier family 52, riboflavin transporter, member 3", "type": "recommended", "evidence": [ { "id": "Q5E9R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1/entry#names_and_taxonomy" } ] }, { "name": "RFT2", "type": "synonym", "evidence": [ { "id": "Q5E9R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1/entry#names_and_taxonomy" } ] }, { "name": "Riboflavin transporter 2", "type": "synonym", "evidence": [ { "id": "Q5E9R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1/entry#names_and_taxonomy" } ] }, { "name": "riboflavin transporter 2", "type": "synonym", "evidence": [ { "id": "NP_001014864", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014864" } ] }, { "name": "solute carrier family 52, riboflavin transporter, member 3", "type": "synonym", "evidence": [ { "id": "NP_001014864", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014864" } ] } ], "function": [ { "annotation": "Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9R1", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1#function" }, { "database": "UniProtKB", "id": "Q9NQ40", "url": "https://www.uniprot.org/uniprotkb/Q9NQ40#function" }, { "database": "UniProtKB", "id": "A0ABI0NYQ7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYQ7#function" }, { "database": "UniProtKB", "id": "RU368035", "url": "https://www.uniprot.org/uniprotkb/RU368035#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9R1", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC52A3", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1", "locus": { "chromosome": "13", "start_pos": 60306866, "end_pos": 60290968, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003977", "url": "https://www.ensembl.org/id/ENSBTAG00000003977" } ] } } ], "crossref": [ { "id": "Q5E9R1", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9R1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003977", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003977", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507459", "url": "https://www.ncbi.nlm.nih.gov/gene/507459", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507459", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507459", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CGAAAQM", "url": "https://omabrowser.org/oma/group/CGAAAQM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9R1", "url": "https://www.orthodb.org/?gene=Q5E9R1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12929", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12929", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12929:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12929:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06237", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06237", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-196843", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196843", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001014864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014864", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "35015", "url": "https://www.rhea-db.org/rhea/35015", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0ABI0NYQ7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9R1", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9R1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFLIHLLVCTFGMGSWVAINGLWVELPLLVTELPEGWYLPSYLTVIIQLANVGPLLVTLLHHFRPGCLSEVAVVFTVLGVGTIACTLFAFLWNVTSWVLGSRHSIAFLVLTFFLALVDCTSSVTFLPFMSRLPTYYLTTFFVGEGLSGLLPALVALAQGSGLTTCVNVTEISATTLSPETTRNMDSPQGASSTLVSKLAGTAPSGIHLESRYLPANFSPLVFFLLLSFMMACCFISFFFLQRQPKRWEASIEDLLTSQVTLNSIRPQEGKDLGPPEESGKAQDPPEEKTAPQHLAHLTFIYVLVAFVNALTNGVLPSVQTYSCLSYGPVAYHLSATLSSMASPLTCFLSIFLPNRSLPFLGVLAVLGTSFGAYNMAMAVMSPCPFMQGHWGGEVLIVVSWVLFTGCLSYVKVMLGVILRDHSRSALLWCGAAVQLGSLLGAVVMFPLVNVLRLFSSADFCSLQCSA", "length": 467, "header": "sp|Q5E9R1-1|S52A3_BOVIN Isoform 1 of Solute carrier family 52, riboflavin transporter, member 3 OS=Bos taurus OX=9913 GN=SLC52A3 PE=2 SV=1 CANONICAL=Q5E9R1-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NYQ7-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1/entry#A0ABI0NYQ7-1", "sequence": { "sequence": "MAFLIHLLVCTFGMGSWVAINGLWVELPLLVTELPEGWYLPSYLTVIIQLANVGPLLVTLLHHFRPGCLSEVAVVFTVLGVGTIACTLFAFLWNVTSWVLGSRHSIAFLVLTFFLALVDCTSSVTFLPFMSRLPTYYLTTFFVGEGLSGLLPALVALAQGSGLTTCVNVTEISATTLSPETTRNMDSPQGASSTLVSKLAGTAPSGIHLESRYLPANFSPLVFFLLLSFMMACCFISFFFLQRQPKRWEASIEDLLTSQVTLNSIRPQEGKDLGPPEESGKAQDPPEEKTAPQHLAHLTFIYVLVAFVNALTNGVLPSVQTYSCLSYGPVAYHLSATLSSMASPLTCFLSIFLPNRSLPFLGVLAVLGTSFGAYNMAMAVMSPCPFMQGHWGGEVLIVSVWTVALSTPNP", "length": 410, "header": "tr|A0ABI0NYQ7-1|A0ABI0NYQ7_BOVIN Computationally mapped isoform of Riboflavin transporter OS=Bos taurus OX=9913 GN=SLC52A3 PE=3 SV=1 CANONICAL=Q5E9R1-1" }, "locus": { "chromosome": "13", "start_pos": 60305174, "end_pos": 60300609, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154277.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154277.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105191.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105191.1" } ] } }, { "isoform_ac": "Q5E9R1-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1/entry#Q5E9R1-1", "sequence": { "sequence": "MAFLIHLLVCTFGMGSWVAINGLWVELPLLVTELPEGWYLPSYLTVIIQLANVGPLLVTLLHHFRPGCLSEVAVVFTVLGVGTIACTLFAFLWNVTSWVLGSRHSIAFLVLTFFLALVDCTSSVTFLPFMSRLPTYYLTTFFVGEGLSGLLPALVALAQGSGLTTCVNVTEISATTLSPETTRNMDSPQGASSTLVSKLAGTAPSGIHLESRYLPANFSPLVFFLLLSFMMACCFISFFFLQRQPKRWEASIEDLLTSQVTLNSIRPQEGKDLGPPEESGKAQDPPEEKTAPQHLAHLTFIYVLVAFVNALTNGVLPSVQTYSCLSYGPVAYHLSATLSSMASPLTCFLSIFLPNRSLPFLGVLAVLGTSFGAYNMAMAVMSPCPFMQGHWGGEVLIVVSWVLFTGCLSYVKVMLGVILRDHSRSALLWCGAAVQLGSLLGAVVMFPLVNVLRLFSSADFCSLQCSA", "length": 467, "header": "sp|Q5E9R1-1|S52A3_BOVIN Isoform 1 of Solute carrier family 52, riboflavin transporter, member 3 OS=Bos taurus OX=9913 GN=SLC52A3 PE=2 SV=1 CANONICAL=Q5E9R1-1" }, "locus": { "chromosome": "13", "start_pos": 60306161, "end_pos": 60300609, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005194.5", "url": "https://www.ensembl.org/id/ENSBTAT00000005194.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005194.2", "url": "https://www.ensembl.org/id/ENSBTAP00000005194.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 168, "start_aa": "Asn", "end_pos": 168, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn168", "evidence": [ { "id": "Q5E9R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 94, "start_aa": "Asn", "end_pos": 94, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn94", "evidence": [ { "id": "Q5E9R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 251, "end_pos": 251, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9R1", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1" } ], "site_lbl": "Ser251" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9R1", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:507459", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507459", "resource": "KEGG Pathway" }, { "id": "R-BTA-196843", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196843", "resource": "Reactome", "description": "Vitamin B2 (riboflavin) metabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YLB1-1", "protein_name": "Riboflavin transporter", "gene_name": "SLC52A3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSLLTHLLACAFGMGSWVAINGLWVELPLLVTVLPEQWDLPSYITIIIQMANVGPLFVTLMHRFWPGSLKEVVVIYVVVSVGIVACLLLAFLWDYTSPIVGTTHSTAFLILTFFLALVDCTSSVTFLPFMMQLQAQYLTTFFIGEGLSGLIPALIALGQGSGISSCANVSQMVNITSDNETMEGTIFRMETRYLPARFSTLIFFLLMTAMMVACLVAFFFLTRQPKVWELSQQQLCPSTIILNSFDQILEDDGGTGRGEGYSCPKSTKRPMETHPEKVSYSVAKLAFIYLLITWVSSLTNGVLPSVQSYSCLPYGNTAYHLSATLSSMANPLACIVAMVLPSRSLALLGTLSLAGTGFGAYNMAIAVMSPCPLLQHSQWGDAIIILSWVLFTGTLSYVKVMAGVILRSRSHSALVWYGALEQLGSLLGALLMFPLVNIYGFFQSADYCSLQCPV", "length": 454 }, "evidence": [ { "id": "Q5E9R1", "url": "https://omabrowser.org/oma/group/Q5E9R1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S866-1", "protein_name": "Riboflavin transporter", "gene_name": "SLC52A3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAFLTHLLVCTFGMGSWVAINGLWVELPLLVTELPEGWYLPSYLTVVIQLANIGPLLITLLHHFRPGCLSEVPIIFTVLGVGTVACTLFAFLWNVTSWVLGGHHSIAFLVLTFFLALVDCTSSVTFLPFMSRLPTHYLTTFFVGEGLSGLLPALVALAQGSGLTTCVNVTETSGTTQNPETTRAMDTSQGAGSTLVSELAGTAAQVVHLESRYLPAHFSPLVFFLLLSFMMACCLVAFFFLQHQHKHWEASTEDLLASQITLQPIRPHKEKDLGPPGPEDSGKGQEPPEEKTAPCHPARLTFIYLLVAFVNALTNGVLPSVQTYSCLSYGPVAYHLSATLSSMANPLACFLSMFLPNRSLPFLGVLAVLGTGFGAYNMAMAVMSPCPLMQGHWGGEVLIVVSWVLFIGCLSYVKVMLGVILRDLSRSALLWCGAAVQLGSLLGAVVMFPLVNVFRLFSSADFCSLQCSA", "length": 469 }, "evidence": [ { "id": "Q5E9R1", "url": "https://omabrowser.org/oma/group/Q5E9R1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3I8Z6-1", "protein_name": "Riboflavin transporter", "gene_name": "Slc52a3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MALLTHLLVCIFGMGSWVAINGLWVELPLLVTELPEGWYLPSYLTVVIQLANIGPLLVTLLHRFQPGCLSEVPVIFLILCIGTAACVLLALLWNTTSWIQGGHHSVAFIVLTFFLALVDCTSSVTFLPFMSQLPTYYLTTFFIGEGLSGLVPALVALAQGSGITTCINATETPGTTLSPVTTVESHITQTAHSPSQSPLTWHLESRYLAPRFSPLLFFLLLSFLMGCCLVAFFILQRQPWGRQGSIEDLLHSQVTLHSIRPRDAEDASSLGAPVTSPGKGSVEVSVASLRPAQLTFIYSVVAFVNALTNGVLPSVQTYSCLPYGPVAYHLSATLSSVASPLACFLPIFLPNRSLLFLGLLTVLGTSFGAYNMAMAAMSPCPILQGHWGGEVLIVLSWVLFAACLSYVKVMLGVILRDRSRSALLWCGAAVQLGSLIGALLMFPLVNVLRLFSSADYCSLDCSV", "length": 463 }, "evidence": [ { "id": "Q5E9R1", "url": "https://omabrowser.org/oma/group/Q5E9R1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q4FZU9-1", "protein_name": "Solute carrier family 52, riboflavin transporter, member 3", "gene_name": "Slc52a3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAFLTHLLVCVFGMGSWVAINGLWVELPLLVTKLPEGWYLPSYLTVVIQLANTGPLLVTLMHRFRPGCLSEVPVIFLILCVGTTACILLAFLWSMTSWIQGRQHSVAFIVLTFFLALVDCTSSVTFLPFMSQLPTYYLTTFFIGEGLSGLLPALVALVQGSGITTCVNVTETPGTTLNPVTTMETSITQRTLSPSLTPLTWHLESRYLAPRFSPLLFFLLLSFLMGCCLVAFFLLQRQPWGRQGSIEDLLHSQVTLHSIKPRDTEDTGSVGAPVSSPGKGSVEVSVASLRPAQLAFIYSVVAFVNALTNGVLPSVQTYSCLPYGPVAYHLSATLSSVASPLACFLPIFLPNRSLLFLGVLTVLGTGFGTYNMAMAAMSPCPILQGHWGGEVLIVLSWMLFVACLSYVKVMLGVILRDRSRSALLWCGAAVQLGSLIGALLMFPLVNVLKLFSSADYCSLDCSA", "length": 463 }, "evidence": [ { "id": "Q5E9R1", "url": "https://omabrowser.org/oma/group/Q5E9R1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D6X5-1", "protein_name": "Solute carrier family 52, riboflavin transporter, member 3", "gene_name": "Slc52a3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFLTHLLVCVFGMGSWVAINGLWVELPLLVTELPEAWYLPSYLTVVIQLANIGPLLVTLMHRFRPGCLSEVPVIFLILCVGTAACILLAFLWNVTSWIQGGQHSVAFIVLTFFLALVDCTSSVTFLPFMSQLPTYYLTTFFIGEGLSGLLPALVALVQGSGITTCVNVTETPGTTLNTMETPITQGNLSPSLPSPSWHQESRYLAPRFSPLLFFLLLSFLTGCCLVAFFLLQRQPWGRQGSIEDLLHSQVTLHSIRPRDTEDTSSLGAPVSSPGKGSVEASVASLRPAQLAFIYSVVAFVNALTNGVLPSVQTYSCLPYGPVAYHLSATLSSVASPLACFLPIFLPNRSLLFLGVLTVLGTGFGAYNMAMAAMSPCPVLQGHWGGEVLIVLSWVLFAACLSYVKVMLGVILRDRSRSALLWCGAAVQLGSLIGALLMFPLVNVLKLFSSADYCSLDCSV", "length": 460 }, "evidence": [ { "id": "Q5E9R1", "url": "https://omabrowser.org/oma/group/Q5E9R1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NQ40-1", "protein_name": "Solute carrier family 52, riboflavin transporter, member 3", "gene_name": "SLC52A3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAFLMHLLVCVFGMGSWVTINGLWVELPLLVMELPEGWYLPSYLTVVIQLANIGPLLVTLLHHFRPSCLSEVPIIFTLLGVGTVTCIIFAFLWNMTSWVLDGHHSIAFLVLTFFLALVDCTSSVTFLPFMSRLPTYYLTTFFVGEGLSGLLPALVALAQGSGLTTCVNVTEISDSVPSPVPTRETDIAQGVPRALVSALPGMEAPLSHLESRYLPAHFSPLVFFLLLSIMMACCLVAFFVLQRQPRCWEASVEDLLNDQVTLHSIRPREENDLGPAGTVDSSQGQGYLEEKAAPCCPAHLAFIYTLVAFVNALTNGMLPSVQTYSCLSYGPVAYHLAATLSIVANPLASLVSMFLPNRSLLFLGVLSVLGTCFGGYNMAMAVMSPCPLLQGHWGGEVLIVASWVLFSGCLSYVKVMLGVVLRDLSRSALLWCGAAVQLGSLLGALLMFPLVNVLRLFSSADFCNLHCPA", "length": 469 }, "evidence": [ { "id": "Q5E9R1", "url": "https://omabrowser.org/oma/group/Q5E9R1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q5E9R1", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "sensory perception of sound", "id": "GO:0007605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", "evidence": [ { "database": "UniProtKB", "id": "Q5E9R1", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1" } ], "pmid": "" }, { "name": "riboflavin transport", "id": "GO:0032218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032218", "evidence": [ { "database": "UniProtKB", "id": "Q5E9R1", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "riboflavin transmembrane transporter activity", "id": "GO:0032217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032217", "evidence": [ { "database": "UniProtKB", "id": "Q5E9R1", "url": "https://www.uniprot.org/uniprotkb/Q5E9R1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 168, "end_pos": 170, "annotation": "n_glycosylation_sequon" }, { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 355, "end_pos": 357, "annotation": "n_glycosylation_sequon" }, { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "35015", "name": "", "equation": "riboflavin(in) = riboflavin(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "35015", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/35015" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9R1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 467, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9R1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9R1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 94, 168 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 251 ], "sequon_annotation_sites": [ { "start_pos": 168, "end_pos": 170 }, { "start_pos": 217, "end_pos": 219 }, { "start_pos": 355, "end_pos": 357 }, { "start_pos": 94, "end_pos": 96 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9R2-1", "uniprot_ac": "Q5E9R2", "uniprot_id": "PLCD_BOVIN", "mass": { "chemical_mass": 43907.0, "monoisotopic_mass": 43907.0 }, "refseq": {}, "gene_names": [ { "name": "AGPAT4", "type": "recommended", "evidence": [ { "id": "Q5E9R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9R2" } ] } ], "protein_names": [ { "name": "1-acyl-sn-glycerol-3-phosphate acyltransferase delta", "type": "recommended", "evidence": [ { "id": "Q5E9R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9R2/entry#names_and_taxonomy" } ] }, { "name": "1-AGP acyltransferase 4", "type": "synonym", "evidence": [ { "id": "Q5E9R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9R2/entry#names_and_taxonomy" } ] }, { "name": "1-AGPAT 4", "type": "synonym", "evidence": [ { "id": "Q5E9R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9R2/entry#names_and_taxonomy" } ] }, { "name": "1-acylglycerol-3-phosphate O-acyltransferase 4", "type": "synonym", "evidence": [ { "id": "Q5E9R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9R2/entry#names_and_taxonomy" } ] }, { "name": "2.3.1.51", "type": "synonym", "evidence": [ { "id": "Q5E9R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9R2/entry#names_and_taxonomy" } ] }, { "name": "LPAAT-delta", "type": "synonym", "evidence": [ { "id": "Q5E9R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9R2/entry#names_and_taxonomy" } ] }, { "name": "Lysophosphatidic acid acyltransferase delta", "type": "synonym", "evidence": [ { "id": "Q5E9R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9R2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9R2", "url": "https://www.uniprot.org/uniprotkb/Q5E9R2#function" }, { "database": "UniProtKB", "id": "Q8K4X7", "url": "https://www.uniprot.org/uniprotkb/Q8K4X7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9R2", "url": "https://www.uniprot.org/uniprotkb/Q5E9R2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AGPAT4", "url": "https://www.uniprot.org/uniprotkb/Q5E9R2", "locus": { "chromosome": "9", "start_pos": 96786351, "end_pos": 96922827, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007668", "url": "https://www.ensembl.org/id/ENSBTAG00000007668" } ] } } ], "crossref": [ { "id": "Q5E9R2", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9R2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07990", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07990", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10983", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10983", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10983:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10983:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01553", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01553", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "19709", "url": "https://www.rhea-db.org/rhea/19709", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "55300", "url": "https://www.rhea-db.org/rhea/55300", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "55304", "url": "https://www.rhea-db.org/rhea/55304", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "55308", "url": "https://www.rhea-db.org/rhea/55308", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "55312", "url": "https://www.rhea-db.org/rhea/55312", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9R2", "url": "https://www.uniprot.org/uniprotkb/Q5E9R2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9R2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9R2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLVALLKSHFLCHLIFCYVFIVSGLIINTIQLCTLLLWPVNKQLFRKINCRLSYCVSSQLVMLLEWWSGTECVIYTDPRAYPKYGKENAIVVLNHKFEIDFLCGWSLAERFGVLGGSKVLAKKELAYVPIIGWMWYFTEMVFCTRKWEQDRKTVSESLLHLRDYPEKYFFLIHCEGTRFTEKKHQISMQVAQAKGLPSLKHHLLPRTKGFAVTVRSLRNVVSAVYDCTLNFRNNENPTLLGVLNGKKYHADLYVRRIPLEEVPEEEDKCAAWLHKLYQEKDAFQEEYSRTGTFPETPVVPPRRPWTLVNWLFWASMLLYPFFRFVINMVSSGSSLTLASFVLVFFVASMGVRWMIGVTEIDKGSAYGNMDSKQKHSD", "length": 378, "header": "sp|Q5E9R2-1|PLCD_BOVIN Isoform 1 of 1-acyl-sn-glycerol-3-phosphate acyltransferase delta OS=Bos taurus OX=9913 GN=AGPAT4 PE=2 SV=1 CANONICAL=Q5E9R2-1" }, "isoforms": [ { "isoform_ac": "Q5E9R2-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9R2/entry#Q5E9R2-1", "sequence": { "sequence": "MDLVALLKSHFLCHLIFCYVFIVSGLIINTIQLCTLLLWPVNKQLFRKINCRLSYCVSSQLVMLLEWWSGTECVIYTDPRAYPKYGKENAIVVLNHKFEIDFLCGWSLAERFGVLGGSKVLAKKELAYVPIIGWMWYFTEMVFCTRKWEQDRKTVSESLLHLRDYPEKYFFLIHCEGTRFTEKKHQISMQVAQAKGLPSLKHHLLPRTKGFAVTVRSLRNVVSAVYDCTLNFRNNENPTLLGVLNGKKYHADLYVRRIPLEEVPEEEDKCAAWLHKLYQEKDAFQEEYSRTGTFPETPVVPPRRPWTLVNWLFWASMLLYPFFRFVINMVSSGSSLTLASFVLVFFVASMGVRWMIGVTEIDKGSAYGNMDSKQKHSD", "length": 378, "header": "sp|Q5E9R2-1|PLCD_BOVIN Isoform 1 of 1-acyl-sn-glycerol-3-phosphate acyltransferase delta OS=Bos taurus OX=9913 GN=AGPAT4 PE=2 SV=1 CANONICAL=Q5E9R2-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 214, "start_aa": "Thr", "end_pos": 214, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr214", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9R2", "url": "https://www.uniprot.org/uniprotkb/Q5E9R2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "1-acylglycerol-3-phosphate O-acyltransferase activity", "id": "GO:0003841", "url": 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}, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9S4-1", "uniprot_ac": "Q5E9S4", "uniprot_id": "AT2L1_BOVIN", "mass": { "chemical_mass": 55313.0, "monoisotopic_mass": 55313.0 }, "refseq": { "ac": "NP_001015605", "name": "ethanolamine-phosphate phospho-lyase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015605" }, "gene_names": [ { "name": "ETNPPL", "type": "recommended", "evidence": [ { "id": "Q5E9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9S4" } ] }, { "name": "AGXT2L1", "type": "synonym", "evidence": [ { "id": "NP_001015605", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015605" }, { "id": "Q5E9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9S4" } ] }, { "name": "ETNPPL", "type": "synonym", "evidence": [ { "id": "NP_001015605", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015605" } ] } ], "protein_names": [ { "name": "Ethanolamine-phosphate phospho-lyase", "type": "recommended", "evidence": [ { "id": "Q5E9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9S4/entry#names_and_taxonomy" } ] }, { "name": "4.2.3.2", "type": "synonym", "evidence": [ { "id": "Q5E9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9S4/entry#names_and_taxonomy" } ] }, { "name": "Alanine--glyoxylate aminotransferase 2-like 1", "type": "synonym", "evidence": [ { "id": "Q5E9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9S4/entry#names_and_taxonomy" } ] }, { "name": "alanine--glyoxylate aminotransferase 2-like 1", "type": "synonym", "evidence": [ { "id": "NP_001015605", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015605" } ] }, { "name": "ethanolamine-phosphate phospho-lyase", "type": "synonym", "evidence": [ { "id": "NP_001015605", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015605" } ] } ], "function": [ { "annotation": "Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S4", "url": "https://www.uniprot.org/uniprotkb/Q5E9S4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9S4", "url": "https://www.uniprot.org/uniprotkb/Q5E9S4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ETNPPL", "url": "https://www.uniprot.org/uniprotkb/Q5E9S4", "locus": { "chromosome": "6", "start_pos": 16573065, "end_pos": 16554146, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010284", "url": "https://www.ensembl.org/id/ENSBTAG00000010284" } ] } } ], "crossref": [ { "id": "Q5E9S4", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9S4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010284", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010284", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00610", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00610", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515186", "url": "https://www.ncbi.nlm.nih.gov/gene/515186", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005814", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005814", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049704", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049704", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515186", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515186", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GAIETMK", "url": "https://omabrowser.org/oma/group/GAIETMK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9S4", "url": "https://www.orthodb.org/?gene=Q5E9S4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45688", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45688", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45688:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45688:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00202", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00202", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1483213", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483213", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015605", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17889", "url": "https://www.rhea-db.org/rhea/17889", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9S4", "url": "https://www.uniprot.org/uniprotkb/Q5E9S4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9S4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9S4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCELYSKQETLALRRKHIGPSCKVFFAADPIKIVRAQRQYMFDEKGDQYLDCINNVAHVGHCHPEVVKAAQKQMELLNTNSRFLHDNIVEYAKRLSATLPDRLSVCYFTNSGSEANDLALRLARQFRGHQDVITLDHAYHGHLSSLIEISPYKFQKGKDVKKEFVHVAPAPDTYRGKYREDHVDPASAYADEVKKIIDEAHNSGRKIAAFIAESMQSCGGQIIPPAGYFQKVAEYVRGAGGVFIADEVQVGFGRVGKHFWSFQMFGEDFVPDIVTMGKPMGNGHPMACVVTTKEIAEAFSASGMEYFNTYGGNPVSSAVGLAVLDVIKNEDLQGNATRVGNYLTELLNKQKTKHTLIGDIRGVGLFIGIDLVKDHQQRTPATAEAQHIIYKMKEKRVLLSADGPHRNVLKIKPPMCFTEEDAKFMVEQLDGILTGLEEATGAETESGISKNTPCRTKMPKEAQSELLRDSSLESRENPSQKRNGLCTDSLLSKRLRT", "length": 497, "header": "sp|Q5E9S4-1|AT2L1_BOVIN Isoform 1 of Ethanolamine-phosphate phospho-lyase OS=Bos taurus OX=9913 GN=ETNPPL PE=2 SV=1 CANONICAL=Q5E9S4-1" }, "isoforms": [ { "isoform_ac": "Q5E9S4-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9S4/entry#Q5E9S4-1", "sequence": { "sequence": "MCELYSKQETLALRRKHIGPSCKVFFAADPIKIVRAQRQYMFDEKGDQYLDCINNVAHVGHCHPEVVKAAQKQMELLNTNSRFLHDNIVEYAKRLSATLPDRLSVCYFTNSGSEANDLALRLARQFRGHQDVITLDHAYHGHLSSLIEISPYKFQKGKDVKKEFVHVAPAPDTYRGKYREDHVDPASAYADEVKKIIDEAHNSGRKIAAFIAESMQSCGGQIIPPAGYFQKVAEYVRGAGGVFIADEVQVGFGRVGKHFWSFQMFGEDFVPDIVTMGKPMGNGHPMACVVTTKEIAEAFSASGMEYFNTYGGNPVSSAVGLAVLDVIKNEDLQGNATRVGNYLTELLNKQKTKHTLIGDIRGVGLFIGIDLVKDHQQRTPATAEAQHIIYKMKEKRVLLSADGPHRNVLKIKPPMCFTEEDAKFMVEQLDGILTGLEEATGAETESGISKNTPCRTKMPKEAQSELLRDSSLESRENPSQKRNGLCTDSLLSKRLRT", "length": 497, "header": "sp|Q5E9S4-1|AT2L1_BOVIN Isoform 1 of Ethanolamine-phosphate phospho-lyase OS=Bos taurus OX=9913 GN=ETNPPL PE=2 SV=1 CANONICAL=Q5E9S4-1" }, "locus": { "chromosome": "6", "start_pos": 16572632, "end_pos": 16554257, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013587.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013587.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013587.4", "url": "https://www.ensembl.org/id/ENSBTAP00000013587.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S4", "url": "https://www.uniprot.org/uniprotkb/Q5E9S4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:515186", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515186", "resource": "KEGG Pathway" }, { "id": "R-BTA-1483213", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483213", "resource": "Reactome", "description": "Synthesis of PE" } ], "orthologs": [ { "uniprot_canonical_ac": "F1S126-1", "protein_name": "Ethanolamine-phosphate phospho-lyase", "gene_name": "ETNPPL", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MCELYSKQDTLALRRKHIGPSCKVFFAADPIKIVRAQRQYMFDEKGDRYLDCINNVAHVGHCHPEVVQAAQKQMELLNTNSRFLHDNIVEYAKRLSATLPDKLSVCYFTNSGSEANDLALRLARQFRGHQDVITLDHAYHGHLTSLIEISPYKFQQGKDVKKEFVHVAPSPDTYRGKYREDHADPAGAYADEVKKIIEEAHNRGRKIAAFIAESMQSCGGQIIPPAGYFQKVAEYVRGAGGVFIADEVQVGFGRVGKHFWSFQMLGEDFVPDIITMGKPMGNGHPMACVVTTREIAEAFSSSGIEYFNTYGGNPVSSAVGLAVLDVIENEDLQGNATRVGNYLTELLNKQKAKHTLIGDIRGVGLFIGIDLVKDREKRTPATAEAQHIIYKMKEKRVLLSADGPHRNVLKIKPPMCFTEEDAKFMVDQLDGILTDLEDAFGAKMENVISENSPCRTRMPNEARSEMLRDGAPDPQENPSHKRNGLCTDKHSLLSKRLKT", "length": 499 }, "evidence": [ { "id": "Q5E9S4", "url": "https://omabrowser.org/oma/group/Q5E9S4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "M0R7F6-1", "protein_name": "Ethanolamine-phosphate phospho-lyase", "gene_name": "Etnppl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRELYSKQDTLALREKHIGPSCKIFFAADPIKIMRARGQYMFDEKGERYLDCINNVAHVGHCHPEVVKAAAKQMELLNTNSRFLHDNIIEFAKRLTATLPQTLSVCYFTNSGYVSEANDLALRLARQFRGHQDVITLEHAYHGHLSSLIEISPYKFQEGKDVKKESVHVAPAPDMYRGKYREDHEDPSTAYADEVKKIIEEAQSRGRKIAAFIAESMQSCGGQIIPPAGYFQKVAEHVRQAGGVFIADEVQVGFGRVGKHFWSFQMSGEDFVPDIVTMGKPMGNGHPISCVVTTKEIAEAFSSSGMEYFNTYGGNPVSCAVGLAVLDVIEKENLQGNAVRVGKHLIELLKEQKAKHPLIGDIRGIGLFIGIDLVKDHEERTPATAEAQHVIYEMKGKGILLSADGPHRNVLKIKPPMCFTKEDAKFLVDHLDDVLTVLEEVMDSRSGSVVSENTACRTKTPKEEHVELPNLSATDAREIHSRKRNGACSDQHVLLSKRLKT", "length": 501 }, "evidence": [ { "id": "Q5E9S4", "url": "https://omabrowser.org/oma/group/Q5E9S4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7SY54-1", "protein_name": "Ethanolamine-phosphate phospho-lyase", "gene_name": "etnppl", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MATETLDKQKTIDLRKKHVGPSCKVFFDHDPIKIVRAKGQYMYNEKDEKYLDCINNVAHVGHCHPDVVSAGAKQMELLNTNSRFLHDSLVLYAQRLQATLPEKLSVCYFVNSGSEANDLALRLAWQYTGHKDIITLDNAYHGHVSSLIDISPYKFHQMAGAEPSQHVHVALSPDTYRGKYREDHPDPATAYAENVKEVIEEAHKKGHEIAAFIAESLQSCGGQVIPPMGYFQKVAQHVRNAGGIFIADEVQVGFGRVGTHFWGFQLQGEDFVPDIVTMGKPIGNGHPMSCVITSREIAESFMSSGMEYFNTFGGNPVSCAIGLAVLNVIEKEDLQGNALHVGGYLTQLLEDLKKRHPLVGDVRGRGLFVGLELVRNQSKRTPATAEAQEVIYRLKEQRILLSADGPHRNVLKFKPPMCFSREDAEFAVEKIDQILTDLEKAMVLQRPEAAILETGHIKRKDASDENGLVHPSNGNSHKHTSTIPLSKKTKRN", "length": 492 }, "evidence": [ { "id": "Q5E9S4", "url": "https://omabrowser.org/oma/group/Q5E9S4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8BWU8-1", "protein_name": "Ethanolamine-phosphate phospho-lyase", "gene_name": "Etnppl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MCELYSKQDTLALRERHIGPSCKIFFAADPIKIMRAQGQYMFDEKGERYLDCINNVAHVGHCHPEVVKAAAKQMELLNTNSRFLHDNIIEFAKRLTATLPQELSVCYFTNSGSEANDLALRLARQFRGHQDVITLDHAYHGHLSSLIEISPYKFQKGKDVKRETVHVAPAPDTYRGKYREDHEDPSTAYADEVKKIIEEAHSSGRKIAAFIAESMQSCGGQIIPPAGYFQKVAEHIHKAGGVFIADEVQVGFGRVGRYFWSFQMYGEDFVPDIVTMGKPMGNGHPISCVVTTKEIAEAFSSSGMEYFNTYGGNPVSCAVGLAVLDVIEKENLQGNAVRVGTYLMELLSEQKAKHPLIGDIRGVGLFIGIDLVKDREKRTPATAEAQHIIYEMKGKGVLLSADGPHRNVLKIKPPMCFTEDDAKFLVDHLDGILTVLEEAMDSKSGTVFSENTAYRTKMPKEIQVELPNLSATEAREIPRGKRNGVCSDQQALLSKRLKT", "length": 499 }, "evidence": [ { "id": "Q5E9S4", "url": "https://omabrowser.org/oma/group/Q5E9S4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TBG4-1", "protein_name": "Ethanolamine-phosphate phospho-lyase", "gene_name": "ETNPPL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MCELYSKRDTLGLRKKHIGPSCKVFFASDPIKIVRAQRQYMFDENGEQYLDCINNVAHVGHCHPGVVKAALKQMELLNTNSRFLHDNIVEYAKRLSATLPEKLSVCYFTNSGSEANDLALRLARQFRGHQDVITLDHAYHGHLSSLIEISPYKFQKGKDVKKEFVHVAPTPDTYRGKYREDHADSASAYADEVKKIIEDAHNSGRKIAAFIAESMQSCGGQIIPPAGYFQKVAEYVHGAGGVFIADEVQVGFGRVGKHFWSFQMYGEDFVPDIVTMGKPMGNGHPVACVVTTKEIAEAFSSSGMEYFNTYGGNPVSCAVGLAVLDIIENEDLQGNAKRVGNYLTELLKKQKAKHTLIGDIRGIGLFIGIDLVKDHLKRTPATAEAQHIIYKMKEKRVLLSADGPHRNVLKIKPPMCFTEEDAKFMVDQLDRILTVLEEAMGTKTESVTSENTPCKTKMLKEAHIELLRDSTTDSKENPSRKRNGMCTDTHSLLSKRLKT", "length": 499 }, "evidence": [ { "id": "Q5E9S4", "url": "https://omabrowser.org/oma/group/Q5E9S4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q940M2-1", "protein_name": "Alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial", "gene_name": "AGT2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MALQRQLLKRATSDIYHRRAISLLRTDFSTSPSIADAPPHIPPFVHQPRPYKGPSADEVLQKRKKFLGPSLFHYYQKPLNIVEGKMQYLYDESGRRYLDAFAGIVTVSCGHCHPDILNAITEQSKLLQHATTIYLHHAIGDFAEALAAKMPGNLKVVYFVNSGSEANELAMMMARLYTGSLEMISLRNAYHGGSSNTIGLTALNTWKYPLPQGEIHHVVNPDPYRGVFGSDGSLYAKDVHDHIEYGTSGKVAGFIAETIQGVGGAVELAPGYLKSVYEIVRNAGGVCIADEVQTGFGRTGSHYWGFQTQDVVPDIVTMAKGIGNGLPLGAVVTTPEIASVLASKILFNTFGGNPVCSAGGLAVLNVIDKEKRQEHCAEVGSHLIQRLKDVQKRHDIIGDVRGRGLMVGIELVSDRKDKTPAKAETSVLFEQLRELGILVGKGGLHGNVFRIKPPMCFTKDDADFLVDALDYSISRL", "length": 476 }, "evidence": [ { "id": "Q5E9S4", "url": "https://omabrowser.org/oma/group/Q5E9S4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VU95-1", "protein_name": "Alanine--glyoxylate aminotransferase 2-like", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPFAHEQLNLVASEQLSKTETIKLRNQHIGQACQLFYRSDPLKIVRGQGQYMFDEEGTRYLDCINNVAHVGHCHPEVVRAGALQMATISTNNRFLHDELVQCARTLTSKMPEPLSVCFFVNSGSEANDLALRLARNFTKRQDVITLDHAYHGHLQSVMEVSPYKFNQPGGEAKPDYVHVAPCPDVYGGKFTDKMYPDADMGALYAQPIEEICQKQLAKGQGVAAFIAESLQSCGGQILPPAGYFQAVYDAVRSAGGVCIADEVQVGFGRVGSHYWAFETQNVIPDIVCVAKPMGNGHPVGAVVTTPEIAQAFHATGVAYFNTYGGNPVSCAIANAVMRVIEEEGLQQKALVLGDYLLEECNRLKQEFECIGDVRGAGLFVGIELVQDRKERIPDKKAAHWVVNRMKQLHRVLVSSDGPNDNVIKLKPPMCFNRENADEFLLGFRECLTAVMQERLASATSAAMAATSGVIATATETLANKTKLFERQDRLIKSV", "length": 494 }, "evidence": [ { "id": "Q5E9S4", "url": "https://omabrowser.org/oma/group/Q5E9S4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S4", "url": "https://www.uniprot.org/uniprotkb/Q5E9S4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S4", "url": "https://www.uniprot.org/uniprotkb/Q5E9S4" } ], "pmid": "" }, { "name": "ethanolamine-phosphate phospho-lyase activity", "id": "GO:0050459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050459", "evidence": [ { "database": "UniProtKB", "id": "Q5E9S4", "url": "https://www.uniprot.org/uniprotkb/Q5E9S4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 335, "end_pos": 337, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17889", "name": "", "equation": "phosphoethanolamine + H2O = acetaldehyde + NH4(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9S4-1" ], "evidence": [ { "id": "17889", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17889" } ] }, { "id": "R-BTA-5696415", "name": "PXLP-K278-ETNPPL tetramer hydrolyses PETA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-5696414" ], "output_participant_list": [ "R-ALL-113532", "R-ALL-5693978" ], "enzyme_list": [ "Q5E9S4-1" ], "evidence": [ { "id": "R-BTA-5696415", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696415" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-113532", "participant_name": "CH3CHO [mitochondrial matrix]", "crossref": [ { "id": "8143150", "database": "PubChem Substance", "url": "" }, { "id": "6277", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "HMDB0000990", "database": "HMDB Metabolite", "url": "" }, { "id": "C00084", "database": "COMPOUND", "url": "" }, { "id": "15343", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-5693978", "participant_name": "NH3 [mitochondrial matrix]", "crossref": [ { "id": "HMDB0033934", "database": "HMDB Metabolite", 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"sp|Q5E9U3-1|TMM79_BOVIN Isoform 1 of Transmembrane protein 79 OS=Bos taurus OX=9913 GN=TMEM79 PE=2 SV=1 CANONICAL=Q5E9U3-1" }, "isoforms": [ { "isoform_ac": "Q5E9U3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9U3/entry#Q5E9U3-1", "sequence": { "sequence": "MTEPETLALLEVKGPETLEKSPPQALVPNGRKLEGEDEVESLGAESSRVGSSAESPTAREGTEDGLDSTVSEAATLPWGTGPQPSAPFPDPPGWRNIEPEPPESEPPTKLEELPEDEASLLPEKAARAFVPIDLQCIERRPQEDLVVCCEASEGEHRRTFLPPRATHPEPPECKWAEAVVKPPGHSCGGCGGCGGREALRAVASVGAALILFPCLLYGAYAFLPFDAPRLPTMSSRLIYTLRCGVFATFPIVLGILVYGLSLLCFAALRPFGEPRREVEIHRQYVAQSVQLFILYFFNLAVLSTYLPQDALKLLPLLTGLFAISRLIYWLTFAVGRSFRGFGYGLTFLPLLSMLLWNFYYMFVVEPERMLTASESRLDYPDHARSASDYRPRSRG", "length": 395, "header": "sp|Q5E9U3-1|TMM79_BOVIN Isoform 1 of Transmembrane protein 79 OS=Bos taurus OX=9913 GN=TMEM79 PE=2 SV=1 CANONICAL=Q5E9U3-1" }, "locus": { "chromosome": "3", "start_pos": 14514651, "end_pos": 14510311, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012416.4", "url": 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"protein_name": "Transmembrane protein 79", "gene_name": "TMEM79", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTEPEAMALLEVKGPAALEKSPPQALVPNGEKTEGEGGAESPRAESSRVGSSAGSPTAGQGTEDGLDSTVSEAATLPWGAGPQPSAPFPDPPGWRDIEPEPLESEPATKLEELPEDDACLLPEKAARAFVPIDLQCIERRPQEDLAVRCEASEGERRRTFLPTRAAPAEPPERKWAEAVVRPPGRSCGGCEGCGGHEGLRAVASVGAAFILFPCLLYGAYAFLPFDAPRLPTMSSRLVYTLRCGVFATFPIVLGILVYGLSLLCFSALRPFGEPRREVEIHRRYVAQSVQLFILYFFNLAVLSTYLPQDTLKLLPLLTGLFAISRLIYWLTFAVGRSFRGFGFGLTFLPLLSMLVWNFYYMFVVEPERMFTVSESRLDYPDHARSALDHRPRLWG", "length": 395 }, "evidence": [ { "id": "Q5E9U3", "url": "https://omabrowser.org/oma/group/Q5E9U3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3T1H8-1", "protein_name": "Transmembrane protein 79", "gene_name": "Tmem79", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTEPETLALLDMKDTEISEKSPPQASVLQPEEEGGTESPGAESLRVGSSVGSPTVREGPEDGPDSTISEAATLPWGTDPHPSAPLPDPPGWRDIGPELLESEAPIKSEEPLKEDANLLPEKTVRAFVPIDLQCIERKPQEERIKHREAGPGELRNFLPARLSHPEPPERKWAEAVVRPPGRSCGGCGSCGGREALRAVASVVAALIFFPCLLYGAYAFLPFDAPRLPTMSSRLVYTLRCGVFATFPIVLGLLVYGLSLLCFSALRPFGEPRREVEIHRQYVAQSVQLFILYFFNLAVLSTYLPQDTLKLLPLLTGLFAISRLIYWLTFAVGRSFRGFGYGLTFLPLLAMLVWNLYYMFVVEPERMLSASESRLDYPDHVRSVSDYRPRSWG", "length": 391 }, "evidence": [ { "id": "Q5E9U3", "url": "https://omabrowser.org/oma/group/Q5E9U3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9BSE2-1", "protein_name": "Transmembrane protein 79", "gene_name": "TMEM79", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTEQETLALLEVKRSDSPEKSSPQALVPNGRQPEGEGGAESPGAESLRVGSSAGSPTAIEGAEDGLDSTVSEAATLPWGTGPQPSAPFPDPPGWRDIEPEPPESEPLTKLEELPEDDANLLPEKAARAFVPIDLQCIERQPQEDLIVRCEAGEGECRTFMPPRVTHPDPTERKWAEAVVRPPGCSCGGCGSCGDREWLRAVASVGAALILFPCLLYGAYAFLPFDVPRLPTMSSRLIYTLRCGVFATFPIVLGILVYGLSLLCFSALRPFGEPRREVEIHRRYVAQSVQLFILYFFNLAVLSTYLPQDTLKLLPLLTGLFAVSRLIYWLTFAVGRSFRGFGYGLTFLPLLSMLMWNLYYMFVVEPERMLTATESRLDYPDHARSASDYRPRPWG", "length": 394 }, "evidence": [ { "id": "Q5E9U3", "url": "https://omabrowser.org/oma/group/Q5E9U3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D709-1", "protein_name": "Transmembrane protein 79", "gene_name": "Tmem79", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTEPETLALLDMKEPETPEKSPPQALVLQSEEEGGTESPGTESLRVGSSVGSPIVREGPEDGPDSTISEAATLPWGTDPHPSAPLPDPPGWRDIEPEPLESEAPTKSEEPFKEDANLLPEKTVRAFVPIDLQCIERKPQEERILHRDAGPGELRNFLPARLSHPEPPERKWAEAVVRPPGRSCGGCGSCGGREALRAVASVVAALIFFPCLLYGAYAFLPFDAPRLPTMSSRLVYTLRCGVFATFPIVLGLLVYGLSLLCFSALRPFGEPRREVEIHRQYVAQSVQLFILYFFNLAVLSTYLPQDTLKLLPLLTGLFAISRLIYWLTFAVGRSFRGFGYGLTFLPLLAMLVWNLYYMFVVEPERMLTASESRLDYPDHARSVSDYRPRSWG", "length": 391 }, "evidence": [ { "id": "Q5E9U3", "url": "https://omabrowser.org/oma/group/Q5E9U3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "trans-Golgi network membrane", "id": "GO:0032588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032588", "evidence": [ { "database": "UniProtKB", "id": "Q5E9U3", "url": "https://www.uniprot.org/uniprotkb/Q5E9U3" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": 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"Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V3", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9V3", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYOZ2", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3", "locus": { "chromosome": "6", "start_pos": 6097594, "end_pos": 6135997, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002574", "url": "https://www.ensembl.org/id/ENSBTAG00000002574" } ] } } ], "crossref": [ { "id": "Q5E9V3", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9V3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002574", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002574", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540487", "url": "https://www.ncbi.nlm.nih.gov/gene/540487", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540487", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540487", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "INHRIAM", "url": "https://omabrowser.org/oma/group/INHRIAM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5E9V3", "url": "https://www.orthodb.org/?gene=Q5E9V3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15941", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15941", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15941:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15941:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05556", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05556", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015676", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9V3", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9V3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSHNTMVKQRKQQASAIMKEIHGNDVDVMHLGKKVSIPRDIMLEELSHLSNRGARLFKMRQRRSDKYTFENFQYETKAQINHNIAMQNEKLDGINLESGSQQAPFTPPNTPDPRSPPNPENIAPGYSGPLKEIPPERFNTTAVPKYYQSPWEQAISNDPELLEALYPKFFKPEGKAELPDYRSFNRVATPFGGFEKASKMVKFKVPDFDLLLLTDPRFMAFANPLSGRRSFNRTPKGWISENIPIVITTEPTEDNTIPESEDL", "length": 264, "header": "sp|Q5E9V3-1|MYOZ2_BOVIN Isoform 1 of Myozenin-2 OS=Bos taurus OX=9913 GN=MYOZ2 PE=2 SV=1 CANONICAL=Q5E9V3-1" }, "isoforms": [ { "isoform_ac": "Q5E9V3-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3/entry#Q5E9V3-1", "sequence": { "sequence": "MLSHNTMVKQRKQQASAIMKEIHGNDVDVMHLGKKVSIPRDIMLEELSHLSNRGARLFKMRQRRSDKYTFENFQYETKAQINHNIAMQNEKLDGINLESGSQQAPFTPPNTPDPRSPPNPENIAPGYSGPLKEIPPERFNTTAVPKYYQSPWEQAISNDPELLEALYPKFFKPEGKAELPDYRSFNRVATPFGGFEKASKMVKFKVPDFDLLLLTDPRFMAFANPLSGRRSFNRTPKGWISENIPIVITTEPTEDNTIPESEDL", "length": 264, "header": "sp|Q5E9V3-1|MYOZ2_BOVIN Isoform 1 of Myozenin-2 OS=Bos taurus OX=9913 GN=MYOZ2 PE=2 SV=1 CANONICAL=Q5E9V3-1" }, "locus": { "chromosome": "6", "start_pos": 6135338, "end_pos": 6097783, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003330.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003330.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003330.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003330.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 101, "end_pos": 101, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V3", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3" } ], "site_lbl": "Ser101" }, { "start_pos": 107, "end_pos": 107, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V3", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3" } ], "site_lbl": "Thr107" }, { "start_pos": 111, "end_pos": 111, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V3", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3" } ], "site_lbl": "Thr111" }, { "start_pos": 116, "end_pos": 116, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V3", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3" } ], "site_lbl": "Ser116" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V3", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:540487", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540487", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2KAQ5-1", "protein_name": "Myozenin 2", "gene_name": "Myoz2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSHSAMVKQRKQQASAITKEIHGHDVDGMDLGKKVSVPRDIMIEELSHFGNRGARLFKMRQRRSDKYTFENFQYETKAQINHNLAMQNGRIDGSNLEGGSQQAPSTPPNTPDPRSPPNPENIAPGYSGPLKEIPPERFNTTAVPKYYQSPWEQAIGDDPELLEALYPKLFKPEGKAELPDYRSFNRVATPFGGFEKASKMVKFKVPDFERLLLTDPRFLAFANPLSGRRCFNRTPKGWISENIPVVITTEPAEDVTMPESDDL", "length": 264 }, "evidence": [ { "id": "Q5E9V3", "url": "https://omabrowser.org/oma/group/Q5E9V3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A1L1RJB3-1", "protein_name": "Myozenin 2", "gene_name": "MYOZ2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLSHSAMVKERKQQASAIMDEIQRNVSPSLNLGKKVSTPRDIMVEELSTLSNRGARLFKRRQRRSDKYTYENYHYVANKPRNRGEPIHSVKMDGLSVEGIPQHAPMTPPNTPDPRSPPHPDNIAPGYSGPLKEIPPEKFNTTSVPKYYQSPWIEAIRDDPELLEALYPKLFKPEAKPELPDYRSFNRVATPFGGFERASKLVKFKVPDYNLLMLNDPRFMILANPLATRRSFNRTPKGWTSENIPVVFIQPSDSNNVPETEDL", "length": 263 }, "evidence": [ { "id": "Q5E9V3", "url": "https://omabrowser.org/oma/group/Q5E9V3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8C2N4T4-1", "protein_name": "Myozenin-2", "gene_name": "Myoz2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLSHSAMVKQRKQQASAITKEIHGNDVDGMNLGKKVSIPRDIMIEELSHFSNRGARLFKMRQRRSDKYTFENFQYETKAQINHNIAMQNGKIDGSNLEGGSQQAPSTPPNTPDPRSPPNPENIAPGYSGPLKEIPPERFNTTAVPKYYQSPWEQAIGSDPELLEALYPKLFKPEGKAELPDYRSFNRVATPFGGFEKASKMVKFKVPDFELLLLTDPRFMAFANPLSGRRSFNRTPKGWISENIPVVITTEPTEDTTVPESDDL", "length": 264 }, "evidence": [ { "id": "Q5E9V3", "url": "https://omabrowser.org/oma/group/Q5E9V3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9JJW5-1", "protein_name": "Myozenin-2", "gene_name": "Myoz2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSHSAMVKQRKQQASAITKEIHGHDVDGMDLGKKVSIPRDIMIEELSHFSNRGARLFKMRQRRSDKYTFENFQYESRAQINHNIAMQNGRVDGSNLEGGSQQGPSTPPNTPDPRSPPNPENIAPGYSGPLKEIPPERFNTTAVPKYYRSPWEQAIGSDPELLEALYPKLFKPEGKAELRDYRSFNRVATPFGGFEKASKMVKFKVPDFELLLLTDPRFLAFANPLSGRRCFNRAPKGWVSENIPVVITTEPTEDATVPESDDL", "length": 264 }, "evidence": [ { "id": "Q5E9V3", "url": "https://omabrowser.org/oma/group/Q5E9V3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NPC6-1", "protein_name": "Myozenin-2", "gene_name": "MYOZ2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLSHNTMMKQRKQQATAIMKEVHGNDVDGMDLGKKVSIPRDIMLEELSHLSNRGARLFKMRQRRSDKYTFENFQYQSRAQINHSIAMQNGKVDGSNLEGGSQQAPLTPPNTPDPRSPPNPDNIAPGYSGPLKEIPPEKFNTTAVPKYYQSPWEQAISNDPELLEALYPKLFKPEGKAELPDYRSFNRVATPFGGFEKASRMVKFKVPDFELLLLTDPRFMSFVNPLSGRRSFNRTPKGWISENIPIVITTEPTDDTTVPESEDL", "length": 264 }, "evidence": [ { "id": "Q5E9V3", "url": "https://omabrowser.org/oma/group/Q5E9V3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V3", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3" } ], "pmid": "" }, { "name": "skeletal muscle fiber adaptation", "id": "GO:0043503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043503", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V3", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3" } ], "pmid": "" }, { "name": "negative regulation of calcineurin-NFAT signaling cascade", "id": "GO:0070885", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070885", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V3", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3" } ], "pmid": "" }, { "name": "sarcomere organization", "id": "GO:0045214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045214", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V3", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3" } ], "pmid": "" }, { "name": "skeletal muscle tissue development", "id": "GO:0007519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007519", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V3", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V3", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3" } ], "pmid": "" }, { "name": "FATZ binding", "id": "GO:0051373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051373", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V3", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3" } ], "pmid": "" }, { "name": "telethonin binding", "id": "GO:0031433", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031433", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V3", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V3", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3" } ], "pmid": "" }, { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "Q5E9V3", "url": "https://www.uniprot.org/uniprotkb/Q5E9V3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9V3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 264, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9V3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9V3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 101, 107, 111, 116 ], "sequon_annotation_sites": [ { "start_pos": 140, "end_pos": 142 }, { "start_pos": 233, "end_pos": 235 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9W5-1", "uniprot_ac": "Q5E9W5", "uniprot_id": "G3ST4_BOVIN", "mass": { "chemical_mass": 53830.0, "monoisotopic_mass": 53830.0 }, "refseq": { "ac": "NP_001029709", "name": "galactose-3-O-sulfotransferase 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029709" }, "gene_names": [ { "name": "GAL3ST4", "type": "recommended", "evidence": [ { "id": "Q5E9W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9W5" } ] }, { "name": "GAL3ST4", "type": "synonym", "evidence": [ { "id": "NP_001029709", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029709" } ] }, { "name": "Gal3ST-4", "type": "synonym", "evidence": [ { "id": "NP_001029709", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029709" } ] } ], "protein_names": [ { "name": "Galactose-3-O-sulfotransferase 4", "type": "recommended", "evidence": [ { "id": "Q5E9W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9W5/entry#names_and_taxonomy" } ] }, { "name": "2.8.2.-", "type": "synonym", "evidence": [ { "id": "Q5E9W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9W5/entry#names_and_taxonomy" } ] }, { "name": "Beta-galactose-3-O-sulfotransferase 4", "type": "synonym", "evidence": [ { "id": "Q5E9W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9W5/entry#names_and_taxonomy" } ] }, { "name": "Gal-beta-1,3-GalNAc 3'-sulfotransferase", "type": "synonym", "evidence": [ { "id": "Q5E9W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9W5/entry#names_and_taxonomy" } ] }, { "name": "Gal3ST-4", "type": "synonym", "evidence": [ { "id": "Q5E9W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9W5/entry#names_and_taxonomy" } ] }, { "name": "beta-galactose-3-O-sulfotransferase 4", "type": "synonym", "evidence": [ { "id": "NP_001029709", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029709" } ] }, { "name": "gal-beta-1,3-GalNAc 3'-sulfotransferase", "type": "synonym", "evidence": [ { "id": "NP_001029709", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029709" } ] }, { "name": "galactose-3-O-sulfotransferase 4", "type": "synonym", "evidence": [ { "id": "NP_001029709", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029709" } ] } ], "function": [ { "annotation": "Catalyzes the transfer of a sulfate group from 3'-phosphoadenylyl sulfate (PAPS) to the C-3 hydroxyl group of terminal non-reducing beta-1,3-linked galactose residues, exclusively in O-linked glycoproteins. Participates in galactose sulfation and acts on core 1 (Gal-beta-1,3-GalNAc-R) structures. In vitro, also recognizes Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc-R, asialofetuin and Gal-beta-1,3(6-O-sulfo)GalNAc-R structures as good substrates.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9W5", "url": "https://www.uniprot.org/uniprotkb/Q5E9W5#function" }, { "database": "UniProtKB", "id": "Q96RP7", "url": "https://www.uniprot.org/uniprotkb/Q96RP7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9W5", "url": "https://www.uniprot.org/uniprotkb/Q5E9W5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GAL3ST4", "url": "https://www.uniprot.org/uniprotkb/Q5E9W5", "locus": { "chromosome": "25", "start_pos": 36247358, "end_pos": 36241705, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015017", "url": "https://www.ensembl.org/id/ENSBTAG00000015017" } ] } } ], "crossref": [ { "id": "Q5E9W5", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9W5", "database": "AlphaFoldDB", "categories": [] }, { "id": "520552", "url": "https://www.ncbi.nlm.nih.gov/gene/520552", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520552", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520552", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9W5", "url": "https://www.orthodb.org/?gene=Q5E9W5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14647", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14647", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14647:SF57", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14647:SF57", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06990", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06990", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029709", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9W5", "url": "https://www.uniprot.org/uniprotkb/Q5E9W5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9W5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9W5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGVLSPTRTMRLWGPRSLGVALGVFMTIGFALQLLGGPFQRRLPGLQLRHSWASSLGPAAPSCPPRQHLVFLKTHKSGSSSVLSLLHRYGDRHGLRFALPARYQFGYPRLFQASRVKGYRPQSGGTQPPFHILCHHMRFNLKEVLQVMPSDSFFFSIVRDPAALARSAFSYYKSTSSAFRKAPSLAAFLANPRAFYRPGARGDHYARNLLWFDFGLPFPPELRTKRGNPHVSRDPNPPQLPSGAGPPAHTLDPNALFHPVPIVADGHSQMSSPASLDLGSSSFIQWNLAWLDSVFDLVLVAEYFDESLVLLADALCWGLDDVVGFMHNAQAGGGQDRSTIDDGGLTTEERQLTARARAWNNLDWALYVHFNRSLWARIKQYGQSRLDSAVAELRARREALAKHCLVGGEALDPKYITDRRFRPFQFGSGKVLGYVLRSGLSLQDQEECERLATPELQYKDKLDAKQFPPTVSLPLKTSRRPSP", "length": 483, "header": "sp|Q5E9W5-1|G3ST4_BOVIN Isoform 1 of Galactose-3-O-sulfotransferase 4 OS=Bos taurus OX=9913 GN=GAL3ST4 PE=2 SV=1 CANONICAL=Q5E9W5-1" }, "isoforms": [ { "isoform_ac": "Q5E9W5-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9W5/entry#Q5E9W5-1", "sequence": { "sequence": "MGVLSPTRTMRLWGPRSLGVALGVFMTIGFALQLLGGPFQRRLPGLQLRHSWASSLGPAAPSCPPRQHLVFLKTHKSGSSSVLSLLHRYGDRHGLRFALPARYQFGYPRLFQASRVKGYRPQSGGTQPPFHILCHHMRFNLKEVLQVMPSDSFFFSIVRDPAALARSAFSYYKSTSSAFRKAPSLAAFLANPRAFYRPGARGDHYARNLLWFDFGLPFPPELRTKRGNPHVSRDPNPPQLPSGAGPPAHTLDPNALFHPVPIVADGHSQMSSPASLDLGSSSFIQWNLAWLDSVFDLVLVAEYFDESLVLLADALCWGLDDVVGFMHNAQAGGGQDRSTIDDGGLTTEERQLTARARAWNNLDWALYVHFNRSLWARIKQYGQSRLDSAVAELRARREALAKHCLVGGEALDPKYITDRRFRPFQFGSGKVLGYVLRSGLSLQDQEECERLATPELQYKDKLDAKQFPPTVSLPLKTSRRPSP", "length": 483, "header": "sp|Q5E9W5-1|G3ST4_BOVIN Isoform 1 of Galactose-3-O-sulfotransferase 4 OS=Bos taurus OX=9913 GN=GAL3ST4 PE=2 SV=1 CANONICAL=Q5E9W5-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 371, "start_aa": "Asn", "end_pos": 371, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn371", "evidence": [ { "id": "Q5E9W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9W5#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9W5", "url": "https://www.uniprot.org/uniprotkb/Q5E9W5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:520552", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520552", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "glycolipid biosynthetic process", "id": "GO:0009247", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009247", "evidence": [ { "database": "UniProtKB", "id": "Q5E9W5", "url": "https://www.uniprot.org/uniprotkb/Q5E9W5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi cisterna membrane", "id": "GO:0032580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032580", "evidence": [ { "database": "UniProtKB", "id": "Q5E9W5", "url": "https://www.uniprot.org/uniprotkb/Q5E9W5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "galactose 3-O-sulfotransferase activity", "id": "GO:0050694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050694", "evidence": [ { "database": "UniProtKB", "id": "Q5E9W5", "url": "https://www.uniprot.org/uniprotkb/Q5E9W5" } ], "pmid": "" }, { "name": "galactosylceramide sulfotransferase activity", "id": "GO:0001733", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001733", "evidence": [ { "database": "UniProtKB", "id": "Q5E9W5", "url": "https://www.uniprot.org/uniprotkb/Q5E9W5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9W5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 483, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9W5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9W5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 371 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 371, "end_pos": 373 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9X0-1", "uniprot_ac": "Q5E9X0", "uniprot_id": "GFRA2_BOVIN", "mass": { "chemical_mass": 51659.0, "monoisotopic_mass": 51659.0 }, "refseq": { "ac": "NP_001015595", "name": "GDNF family receptor alpha-2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015595" }, "gene_names": [ { "name": "GFRA2", "type": "recommended", "evidence": [ { "id": "Q5E9X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X0" } ] }, { "name": "GFRA2", "type": "synonym", "evidence": [ { "id": "NP_001015595", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015595" } ] } ], "protein_names": [ { "name": "GDNF family receptor alpha-2", "type": "recommended", "evidence": [ { "id": "Q5E9X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X0/entry#names_and_taxonomy" } ] }, { "name": "GDNF family receptor alpha-2 precursor", "type": "synonym", "evidence": [ { "id": "NP_001015595", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015595" } ] }, { "name": "GDNF receptor alpha-2", "type": "synonym", "evidence": [ { "id": "NP_001015595", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015595" }, { "id": "Q5E9X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X0/entry#names_and_taxonomy" } ] }, { "name": "GDNFR-alpha-2", "type": "synonym", "evidence": [ { "id": "NP_001015595", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015595" }, { "id": "Q5E9X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X0/entry#names_and_taxonomy" } ] }, { "name": "GFR-alpha-2", "type": "synonym", "evidence": [ { "id": "NP_001015595", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015595" }, { "id": "Q5E9X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "GFRA2 influences basal metabolic rates, suggesting a mechanism by which genetic variation may contribute to Residual feed intake. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001015595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015595" }, { "database": "PubMed", "id": "30250203", "url": "https://glygen.org/publication/PubMed/30250203" } ] }, { "annotation": "Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons. NRTN-binding leads to autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X0", "url": "https://www.uniprot.org/uniprotkb/Q5E9X0#function" }, { "database": "UniProtKB", "id": "O00451", "url": "https://www.uniprot.org/uniprotkb/O00451#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9X0", "url": "https://www.uniprot.org/uniprotkb/Q5E9X0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GFRA2", "url": "https://www.uniprot.org/uniprotkb/Q5E9X0", "locus": { "chromosome": "8", "start_pos": 68996147, "end_pos": 69102300, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020665", "url": "https://www.ensembl.org/id/ENSBTAG00000020665" } ] } } ], "crossref": [ { "id": "Q5E9X0", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9X0", "database": "AlphaFoldDB", "categories": [] }, { "id": "514036", "url": "https://www.ncbi.nlm.nih.gov/gene/514036", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016017", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016017", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037193", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037193", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514036", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514036", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9X0", "url": "https://www.orthodb.org/?gene=Q5E9X0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10269", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10269", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10269:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10269:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02351", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02351", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015595", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9X0", "url": "https://www.uniprot.org/uniprotkb/Q5E9X0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9X0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MILANAFCLFFFLDETLRSLASPSSPQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTARLSDIFRLASIFSGTGADPAVSTKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRSLCRTDHLCRSRLADFHANCRASYQTLTSCPTDNYQACLGSYAGMIGFDITPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLKDFTENPCLRNAIQAFGNGTDVNLSPKSPPFQATQAPRVDKTPSLPDDLSDSTSLGTSVISTCTSVQDQGLKANNSKELSMCFTELTTNIIPGSKRVIKPNSGPRRTRPSAALTAASFLMLKLAL", "length": 464, "header": "sp|Q5E9X0-1|GFRA2_BOVIN Isoform 1 of GDNF family receptor alpha-2 OS=Bos taurus OX=9913 GN=GFRA2 PE=2 SV=1 CANONICAL=Q5E9X0-1" }, "isoforms": [ { "isoform_ac": "Q5E9X0-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X0/entry#Q5E9X0-1", "sequence": { "sequence": "MILANAFCLFFFLDETLRSLASPSSPQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTARLSDIFRLASIFSGTGADPAVSTKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRSLCRTDHLCRSRLADFHANCRASYQTLTSCPTDNYQACLGSYAGMIGFDITPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLKDFTENPCLRNAIQAFGNGTDVNLSPKSPPFQATQAPRVDKTPSLPDDLSDSTSLGTSVISTCTSVQDQGLKANNSKELSMCFTELTTNIIPGSKRVIKPNSGPRRTRPSAALTAASFLMLKLAL", "length": 464, "header": "sp|Q5E9X0-1|GFRA2_BOVIN Isoform 1 of GDNF family receptor alpha-2 OS=Bos taurus OX=9913 GN=GFRA2 PE=2 SV=1 CANONICAL=Q5E9X0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 357, "start_aa": "Asn", "end_pos": 357, "end_aa": "Asn", 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"id": "ENSBTAP00000007978.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007978.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 23, "end_pos": 23, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X4", "url": "https://www.uniprot.org/uniprotkb/Q5E9X4" } ], "site_lbl": "Ser23" }, { "start_pos": 25, "end_pos": 25, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X4", "url": "https://www.uniprot.org/uniprotkb/Q5E9X4" } ], "site_lbl": "Ser25" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X4", "url": "https://www.uniprot.org/uniprotkb/Q5E9X4" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:532659", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532659", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7HDV9-1", "protein_name": "Leucine-rich repeat-containing protein 59", "gene_name": "Lrrc59", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATVLDLSCNKLSTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQQAKEAKERELRKREKAEEKERRRKEYDAQKASKREQEKKPKKETNQAPKSKSGSRPRKPPPRKHNRSWVVLKVLLLLLLLCVAGGLVACRMTGLQQQPLCNSVNTIYDNAVQGLRHHEILQWVLQTDSQQ", "length": 307 }, "evidence": [ { "id": "Q5E9X4", "url": "https://omabrowser.org/oma/group/Q5E9X4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3L995-1", "protein_name": "Leucine-rich repeat-containing protein 59", "gene_name": "LRRC59", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALSKATILDLSCNKLTTLPSEFCGLTHLVKLDLSKNKLRQLPADFGRLVNLQHLDLLNNRLVTLPVSFAQLKSLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCANKVLQHMKAVQADQERERQRRLEIDREAEKKWEAKQRAKEAQERELRKREKAEEKERRRKEYDALKAAKREQEKKPKKETNQAPKSKSGSRPRKPPPRKHTRSWAVLKLLLLLLLCVAGGLVACRVTELQQQPLCTSVNTIYDNAVRGLRSHDIVQWVLQTDSQQ", "length": 306 }, "evidence": [ { "id": "Q5E9X4", "url": "https://omabrowser.org/oma/group/Q5E9X4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5RJR8-1", "protein_name": "Leucine-rich repeat-containing protein 59", "gene_name": "Lrrc59", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTKTGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATVLDLSCNKLSTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNRLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQQAKEAKERELRKREKAEEKERRRKEYDAQKASKREQEKKPKKETNQAPKSKSGSRPRKPPPRKHNRSWAVLKGLLLLLLLCVAGGLVVCRVTGLQQQPLCTSVNAIYDNAVQGLRHHEILQWVLQTDSQQ", "length": 307 }, "evidence": [ { "id": "Q5E9X4", "url": "https://omabrowser.org/oma/group/Q5E9X4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q922Q8-1", "protein_name": "Leucine-rich repeat-containing protein 59", "gene_name": "Lrrc59", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATVLDLSCNKLSTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNRLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQQAKEAKERELRKREKAEEKERRRKEYDAQKASKREQEKKPKKEANQAPKSKSGSRPRKPPPRKHTRSWAVLKVLLLLLLLCVAGGLVVCRVTGLHQQPLCTSVNTIYDNAVQGLRHHEILQWVLQTDSQQ", "length": 307 }, "evidence": [ { "id": "Q5E9X4", "url": "https://omabrowser.org/oma/group/Q5E9X4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96AG4-1", "protein_name": "Leucine-rich repeat-containing protein 59", "gene_name": "LRRC59", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKAEEKERRRKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRKPPPRKHTRSWAVLKLLLLLLLFGVAGGLVACRVTELQQQPLCTSVNTIYDNAVQGLRRHEILQWVLQTDSQQ", "length": 307 }, "evidence": [ { "id": "Q5E9X4", "url": "https://omabrowser.org/oma/group/Q5E9X4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X4", "url": "https://www.uniprot.org/uniprotkb/Q5E9X4" } ], "pmid": "" }, { "name": "mitochondrial nucleoid", "id": "GO:0042645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042645", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X4", "url": "https://www.uniprot.org/uniprotkb/Q5E9X4" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X4", "url": "https://www.uniprot.org/uniprotkb/Q5E9X4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5E9X4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 306, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5E9X4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5E9X4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 23, 25 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5E9X6-1", "uniprot_ac": "Q5E9X6", "uniprot_id": "SPSB1_BOVIN", "mass": { "chemical_mass": 30811.0, "monoisotopic_mass": 30811.0 }, "refseq": { "ac": "NP_001029381", "name": "SPRY domain-containing SOCS box protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029381" }, "gene_names": [ { "name": "SPSB1", "type": "recommended", "evidence": [ { "id": "Q5E9X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X6" } ] }, { "name": "SPSB1", "type": "synonym", "evidence": [ { "id": "NP_001029381", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029381" } ] }, { "name": "SSB1", "type": "synonym", "evidence": [ { "id": "NP_001029381", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029381" }, { "id": "Q5E9X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X6" } ] } ], "protein_names": [ { "name": "SPRY domain-containing SOCS box protein 1", "type": "recommended", "evidence": [ { "id": "Q5E9X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X6/entry#names_and_taxonomy" } ] }, { "name": "SPRY domain-containing SOCS box protein 1", "type": "synonym", "evidence": [ { "id": "NP_001029381", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029381" } ] }, { "name": "SPRY domain-containing SOCS box protein SSB-1", "type": "synonym", "evidence": [ { "id": "NP_001029381", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029381" } ] }, { "name": "SSB-1", "type": "synonym", "evidence": [ { "id": "Q5E9X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X6", "url": "https://www.uniprot.org/uniprotkb/Q5E9X6#function" }, { "database": "UniProtKB", "id": "Q96BD6", "url": "https://www.uniprot.org/uniprotkb/Q96BD6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5E9X6", "url": "https://www.uniprot.org/uniprotkb/Q5E9X6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPSB1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X6", "locus": { "chromosome": "16", "start_pos": 44108087, "end_pos": 44138193, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024539", "url": "https://www.ensembl.org/id/ENSBTAG00000024539" } ] } } ], "crossref": [ { "id": "Q5E9X6", "url": "https://alphafold.ebi.ac.uk/entry/Q5E9X6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12906", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12906", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504407", "url": "https://www.ncbi.nlm.nih.gov/gene/504407", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050672", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050672", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504407", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504407", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5E9X6", "url": "https://www.orthodb.org/?gene=Q5E9X6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12245", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12245", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12245:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12245:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07525", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07525", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029381", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5E9X6", "url": "https://www.uniprot.org/uniprotkb/Q5E9X6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5E9X6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLCRRSVRLALGKGRLGEIHALPLPASLKAYLLYQ", "length": 273, "header": "sp|Q5E9X6-1|SPSB1_BOVIN Isoform 1 of SPRY domain-containing SOCS box protein 1 OS=Bos taurus OX=9913 GN=SPSB1 PE=2 SV=1 CANONICAL=Q5E9X6-1" }, "isoforms": [ { "isoform_ac": "Q5E9X6-1", "url": "https://www.uniprot.org/uniprotkb/Q5E9X6/entry#Q5E9X6-1", "sequence": { "sequence": "MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLCRRSVRLALGKGRLGEIHALPLPASLKAYLLYQ", "length": 273, "header": "sp|Q5E9X6-1|SPSB1_BOVIN Isoform 1 of SPRY domain-containing SOCS box protein 1 OS=Bos taurus OX=9913 GN=SPSB1 PE=2 SV=1 CANONICAL=Q5E9X6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 31, "end_pos": 31, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X6", "url": "https://www.uniprot.org/uniprotkb/Q5E9X6" } ], "site_lbl": "Tyr31" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5E9X6", "url": "https://www.uniprot.org/uniprotkb/Q5E9X6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:504407", "name": "", "url": 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Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. 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} ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA10-1", "uniprot_ac": "Q5EA10", "uniprot_id": "PIGM_BOVIN", "mass": { "chemical_mass": 49553.0, "monoisotopic_mass": 49553.0 }, "refseq": { "ac": "NP_001015563", "name": "GPI alpha-1,4-mannosyltransferase I, catalytic subunit", "summary": "", "url": 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"https://www.ncbi.nlm.nih.gov/protein/NP_001015563" } ] }, { "name": "GPI mannosyltransferase 1", "type": "synonym", "evidence": [ { "id": "NP_001015563", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015563" } ] }, { "name": "GPI mannosyltransferase I", "type": "synonym", "evidence": [ { "id": "NP_001015563", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015563" }, { "id": "Q5EA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA10/entry#names_and_taxonomy" } ] }, { "name": "GPI-MT-I", "type": "synonym", "evidence": [ { "id": "NP_001015563", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015563" }, { "id": "Q5EA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA10/entry#names_and_taxonomy" } ] }, { "name": "PIG-M mannosyltransferase", "type": "synonym", "evidence": [ { "id": "NP_001015563", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015563" } ] }, { "name": "PIG-M", "type": "synonym", "evidence": [ { "id": "Q5EA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA10/entry#names_and_taxonomy" } ] }, { "name": "Phosphatidylinositol-glycan biosynthesis class M protein", "type": "synonym", "evidence": [ { "id": "Q5EA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA10/entry#names_and_taxonomy" } ] }, { "name": "phosphatidylinositol glycan, class M", "type": "synonym", "evidence": [ { "id": "NP_001015563", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015563" } ] }, { "name": "phosphatidylinositol-glycan biosynthesis class M protein", "type": "synonym", "evidence": [ { "id": "NP_001015563", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015563" } ] } ], "function": [ { "annotation": "Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to a 2-acyl-6-alpha-D-glucosaminyl-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (glucosaminyl acyl phosphatidylinositol, GlcN-(acyl)PI) intermediate to generate 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H2) and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.", "evidence": [ { "database": "UniProtKB", "id": "Q5EA10", "url": "https://www.uniprot.org/uniprotkb/Q5EA10#function" }, { "database": "UniProtKB", "id": "Q9H3S5", "url": "https://www.uniprot.org/uniprotkb/Q9H3S5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA10", "url": "https://www.uniprot.org/uniprotkb/Q5EA10" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PIGM", "url": "https://www.uniprot.org/uniprotkb/Q5EA10", "locus": { "chromosome": "3", "start_pos": 9652954, "end_pos": 9643975, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002419", "url": "https://www.ensembl.org/id/ENSBTAG00000002419" } ] } } ], "crossref": [ { "id": "Q5EA10", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA10", "database": "AlphaFoldDB", "categories": [] }, { "id": "509680", "url": "https://www.ncbi.nlm.nih.gov/gene/509680", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007704", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007704", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509680", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509680", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5EA10", "url": "https://www.orthodb.org/?gene=Q5EA10", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12886", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12886", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12886:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12886:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05007", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05007", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015563", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "60500", "url": "https://www.rhea-db.org/rhea/60500", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5EA10", "url": "https://www.uniprot.org/uniprotkb/Q5EA10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA10-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA10-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPTTHWGDKFLNLRVPPAGVFVVAFFARVALIFYGVFQDRTLLVRYTDIDYQVFTDAARFVTEGHSPYLRATYRYTPLLAWLLTPNIYLNELFGKFLFISFDLFTAFLLYRLLLLKGLGRRQACGYCVFWLLNPLPMAVSSRGNADSIVASLVLMTLYLIEKRLVACAAVSYGFAVHLKMYPVTYILPIALHLLPERDSDEGLRQSRYSFQVRLYEFLKRLCHRAVLLFVAVAGLTFFALSFGFYYRYGWEFLEHAYLYHLTRRDIRHNFSPYFYMLYLTAESKWSFSLGIAAFLPQFILLSAVSFAYYRDLVFCCFLHTSIFVTFNKVCTSQYFLWYLCLLPLVMPLVRIPWRRAVVLLMLWFIGQALWLAPAYVLEFQGKNTFLFIWLAGLFFLLINCSILIQIISHYKEEPLTDRTKYD", "length": 423, "header": "sp|Q5EA10-1|PIGM_BOVIN Isoform 1 of GPI alpha-1,4-mannosyltransferase I, catalytic subunit OS=Bos taurus OX=9913 GN=PIGM PE=2 SV=1 CANONICAL=Q5EA10-1" }, "isoforms": [ { "isoform_ac": "Q5EA10-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA10/entry#Q5EA10-1", "sequence": { "sequence": "MSPTTHWGDKFLNLRVPPAGVFVVAFFARVALIFYGVFQDRTLLVRYTDIDYQVFTDAARFVTEGHSPYLRATYRYTPLLAWLLTPNIYLNELFGKFLFISFDLFTAFLLYRLLLLKGLGRRQACGYCVFWLLNPLPMAVSSRGNADSIVASLVLMTLYLIEKRLVACAAVSYGFAVHLKMYPVTYILPIALHLLPERDSDEGLRQSRYSFQVRLYEFLKRLCHRAVLLFVAVAGLTFFALSFGFYYRYGWEFLEHAYLYHLTRRDIRHNFSPYFYMLYLTAESKWSFSLGIAAFLPQFILLSAVSFAYYRDLVFCCFLHTSIFVTFNKVCTSQYFLWYLCLLPLVMPLVRIPWRRAVVLLMLWFIGQALWLAPAYVLEFQGKNTFLFIWLAGLFFLLINCSILIQIISHYKEEPLTDRTKYD", "length": 423, "header": "sp|Q5EA10-1|PIGM_BOVIN Isoform 1 of GPI alpha-1,4-mannosyltransferase I, catalytic subunit OS=Bos taurus OX=9913 GN=PIGM PE=2 SV=1 CANONICAL=Q5EA10-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycosyltransferase-activity" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA10", "url": "https://www.uniprot.org/uniprotkb/Q5EA10" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:509680", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509680", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q5EA10", "url": "https://www.uniprot.org/uniprotkb/Q5EA10" } ], "pmid": "" }, { "name": "glycosylphosphatidylinositol-mannosyltransferase I complex", "id": "GO:1990529", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990529", "evidence": [ { "database": "UniProtKB", "id": "Q5EA10", "url": "https://www.uniprot.org/uniprotkb/Q5EA10" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "mannosyltransferase activity", "id": "GO:0000030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000030", "evidence": [ { "database": "UniProtKB", "id": "Q5EA10", "url": "https://www.uniprot.org/uniprotkb/Q5EA10" } ], "pmid": "" }, { "name": "dol-P-Man:GlcN-acyl-PI alpha-1,4-mannosyltransferase activity", "id": "GO:0180041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0180041", "evidence": [ { "database": "UniProtKB", "id": "Q5EA10", "url": "https://www.uniprot.org/uniprotkb/Q5EA10" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "GPI anchor biosynthetic process", "id": "GO:0006506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006506", "evidence": [ { "database": "UniProtKB", "id": "Q5EA10", "url": "https://www.uniprot.org/uniprotkb/Q5EA10" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 270, "end_pos": 272, "annotation": "n_glycosylation_sequon" }, { "start_pos": 400, "end_pos": 402, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "60500", "name": "", "equation": "a 2-acyl-6-alpha-D-glucosaminyl-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = a 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a di-trans,poly-cis-dolichyl phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5EA10-1" ], "evidence": [ { "id": "60500", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60500" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q5EA10", "gene_name": "PIGM", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q5EA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA10" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA10-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 423, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA10-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA10" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 270, "end_pos": 272 }, { "start_pos": 400, "end_pos": 402 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA11-1", "uniprot_ac": "Q5EA11", "uniprot_id": "CNS1_BOVIN", "mass": { "chemical_mass": 44373.0, "monoisotopic_mass": 44373.0 }, "refseq": { "ac": "NP_001015554", "name": "hsp70/Hsp90 co-chaperone CNS1 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015554" }, "gene_names": [ { "name": "TTC4", "type": "recommended", "evidence": [ { "id": "Q5EA11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA11" } ] }, { "name": "TTC4", "type": "synonym", "evidence": [ { "id": "NP_001015554", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015554" } ] } ], "protein_names": [ { "name": "Hsp70/Hsp90 co-chaperone CNS1 homolog", "type": "recommended", "evidence": [ { "id": "Q5EA11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA11/entry#names_and_taxonomy" } ] }, { "name": "TPR repeat protein 4", "type": "synonym", "evidence": [ { "id": "NP_001015554", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015554" }, { "id": "Q5EA11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA11/entry#names_and_taxonomy" } ] }, { "name": "Tetratricopeptide repeat protein 4", "type": "synonym", "evidence": [ { "id": "Q5EA11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA11/entry#names_and_taxonomy" } ] }, { "name": "hsp70/Hsp90 co-chaperone CNS1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001015554", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015554" } ] }, { "name": "tetratricopeptide repeat protein 4", "type": "synonym", "evidence": [ { "id": "NP_001015554", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015554" } ] } ], "function": [ { "annotation": "Co-chaperone that recruits molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1) to nascent polypeptides, facilitating their proper folding into functional proteins (By similarity). Client proteins include eukaryotic elongation factor eEF2, a key player in cellular translation. Stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5EA11", "url": "https://www.uniprot.org/uniprotkb/Q5EA11#function" }, { "database": "UniProtKB", "id": "O95801", "url": "https://www.uniprot.org/uniprotkb/O95801#function" }, { "database": "UniProtKB", "id": "P33313", "url": "https://www.uniprot.org/uniprotkb/P33313#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA11", "url": "https://www.uniprot.org/uniprotkb/Q5EA11" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TTC4", "url": "https://www.uniprot.org/uniprotkb/Q5EA11", "locus": { "chromosome": "3", "start_pos": 91536057, "end_pos": 91564929, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015931", "url": "https://www.ensembl.org/id/ENSBTAG00000015931" } ] } } ], "crossref": [ { "id": "Q5EA11", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA11", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd21380", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21380", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509047", "url": "https://www.ncbi.nlm.nih.gov/gene/509047", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044059", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044059", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509047", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509047", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5EA11", "url": "https://www.orthodb.org/?gene=Q5EA11", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46035", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46035", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46035:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46035:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF18972", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18972", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015554", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EA11", "url": "https://www.uniprot.org/uniprotkb/Q5EA11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA11-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA11-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQQEPGATLDDGMDSFLEKFQSQPYRGGFHESQWEEEFEKIPLFMKNSPSEIDPLENPDLACLQSIIFDEERSPEDQARTYKDEGNDYFKEKDYKKAVISYTEGLKKKCADPDLNAVLYTNRAAAQYYLGNFRSSLNDVTAARKLKPCHLKAIIRGASCHLELKNYVEAVNWCDEGLQIDATEKKLLDLRAKADKLKRTEQRDVRKAKLKEKKQQDQNEALLQAIKARNIRLVAEAAGEDEDSASEGLSELVLYGLSSENPCGARLGVDDQGRLSWPVLFLYPEYAQSDLVSAFHEDSRFIDHLMVMFGETPSWDLEQKYCPDNLEVYFEDEDRAELYCVPPSSTLLQVLQHPRYFVKALTPTFLVCVGSSGFCRNYLRGKKVHQVK", "length": 388, "header": "sp|Q5EA11-1|CNS1_BOVIN Isoform 1 of Hsp70/Hsp90 co-chaperone CNS1 homolog OS=Bos taurus OX=9913 GN=TTC4 PE=2 SV=2 CANONICAL=Q5EA11-1" }, "isoforms": [ { "isoform_ac": "Q5EA11-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA11/entry#Q5EA11-1", "sequence": { "sequence": 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"date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA25-1", "uniprot_ac": "Q5EA25", "uniprot_id": "SRPX2_BOVIN", "mass": { "chemical_mass": 53068.0, "monoisotopic_mass": 53068.0 }, "refseq": { "ac": "NP_001014926", "name": "sushi repeat-containing protein SRPX2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014926" }, "gene_names": [ { "name": "SRPX2", "type": "recommended", "evidence": [ { "id": "Q5EA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" } ] }, { "name": "SRPX2", "type": "synonym", "evidence": [ { "id": "NP_001014926", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014926" } ] } ], "protein_names": [ { "name": "Sushi repeat-containing protein SRPX2", "type": "recommended", "evidence": [ { "id": "Q5EA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA25/entry#names_and_taxonomy" } ] }, { "name": "sushi repeat-containing protein SRPX2 precursor", "type": "synonym", "evidence": [ { "id": "NP_001014926", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014926" } ] }, { "name": "sushi repeat-containing protein SRPX2", "type": "synonym", "evidence": [ { "id": "NP_001014926", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014926" } ] } ], "function": [ { "annotation": "Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5EA25", "url": "https://www.uniprot.org/uniprotkb/Q5EA25#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA25", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SRPX2", "url": "https://www.uniprot.org/uniprotkb/Q5EA25", "locus": { "chromosome": "X", "start_pos": 49677923, "end_pos": 49648346, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037686", "url": "https://www.ensembl.org/id/ENSBTAG00000037686" } ] } } ], "crossref": [ { "id": "Q5EA25", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA25", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00033", "url": 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] }, { "id": "bta:514742", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514742", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5EA25", "url": "https://www.orthodb.org/?gene=Q5EA25", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46343", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46343", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46343:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46343:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00084", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00084", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02494", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02494", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13778", "url": 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"MAIQLTRRGALSLLLFLTPAVMPTWYAGSGYYPDESYNEVYAEEVPQTPILDYKVPRWCYTLNIQDGEATCYSPRGGNYHSSLGTRCELSCDRGFRLIGRRSVQCLPSRRWSGTAYCRQMRCHALPFITSGTYTCTNGVLLDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVCVDIDPPKIRCPHSREKMAEPEKLTARVYWDPPVVKDSADGTITRLTLRGPEPGSHFPEGEHVIRYTAYDRAYNRASCKFIVKVQVRRCPTLKPPLHGYLTCTSAGDNYGATCEYHCDGGYERQGTSSRVCQSSRQWSGSPPVCVPMKINVNVNSAAGLLDQFYEKRRLLIISAPDPSNRYYKMQISMLQQSTCGLDLRHVTIIELVGQPPQEVGRIREHQLSANIIEELRQFQHLTRSYFNMVLIDKQGIDRERYMEPVTPEEIFTFIDDYLLSNEELIQRREQRDICD", "length": 465, "header": "sp|Q5EA25-1|SRPX2_BOVIN Isoform 1 of Sushi repeat-containing protein SRPX2 OS=Bos taurus OX=9913 GN=SRPX2 PE=2 SV=1 CANONICAL=Q5EA25-1" }, "isoforms": [ { "isoform_ac": "Q5EA25-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA25/entry#Q5EA25-1", "sequence": { "sequence": 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Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA25", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:514742", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514742", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "hepatocyte growth factor binding", "id": "GO:0036458", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036458", "evidence": [ { "database": "UniProtKB", "id": "Q5EA25", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" } ], "pmid": "" }, { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "Q5EA25", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q5EA25", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "Q5EA25", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "Q5EA25", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" } ], "pmid": "" }, { "name": "positive regulation of synapse assembly", "id": "GO:0051965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051965", "evidence": [ { "database": "UniProtKB", "id": "Q5EA25", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" } ], "pmid": "" }, { "name": "positive regulation of cell migration involved in sprouting angiogenesis", "id": "GO:0090050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090050", "evidence": [ { "database": "UniProtKB", "id": "Q5EA25", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" } ], "pmid": "" }, { "name": "cell motility", "id": "GO:0048870", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048870", "evidence": [ { "database": "UniProtKB", "id": "Q5EA25", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" } ], "pmid": "" }, { "name": "regulation of phosphorylation", "id": "GO:0042325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042325", "evidence": [ { "database": "UniProtKB", "id": "Q5EA25", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q5EA25", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5EA25", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "Q5EA25", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" } ], "pmid": "" }, { "name": "synaptic membrane", "id": "GO:0097060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097060", "evidence": [ { "database": "UniProtKB", "id": "Q5EA25", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" } ], "pmid": "" }, { "name": "excitatory synapse", "id": "GO:0060076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060076", "evidence": [ { "database": "UniProtKB", "id": "Q5EA25", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA25-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 465, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA25-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA25" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5EA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" }, { "id": "PRU00113", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00113" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HYR", "eco_id": "ECO_0000255", "start_pos": 177, "end_pos": 261, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5EA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" }, { "id": "PRU00302", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00302" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sushi 1", "eco_id": "ECO_0000255", "start_pos": 69, "end_pos": 119, "start_aa": "Ala", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5EA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" }, { "id": "PRU00302", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00302" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sushi 2", "eco_id": "ECO_0000255", "start_pos": 120, "end_pos": 178, "start_aa": "Met", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5EA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA25" }, { "id": "PRU00302", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00302" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sushi 3", "eco_id": "ECO_0000255", "start_pos": 262, "end_pos": 321, "start_aa": "Arg", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA36-1", "uniprot_ac": "Q5EA36", "uniprot_id": "RBM14_BOVIN", "mass": { "chemical_mass": 69603.0, "monoisotopic_mass": 69603.0 }, "refseq": { "ac": "NP_001014901", "name": "RNA-binding protein 14", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014901" }, "gene_names": [ { "name": "RBM14", "type": "recommended", "evidence": [ { "id": "Q5EA36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA36" } ] }, { "name": "RBM14", "type": "synonym", "evidence": [ { "id": "NP_001014901", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014901" } ] } ], "protein_names": [ { "name": "RNA-binding protein 14", "type": "recommended", "evidence": [ { "id": "Q5EA36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA36/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding motif protein 14", "type": "synonym", "evidence": [ { "id": "Q5EA36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA36/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding protein 14", "type": "synonym", "evidence": [ { "id": "NP_001014901", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014901" } ] } ], "function": [ { "annotation": "May function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q5EA36", "url": "https://www.uniprot.org/uniprotkb/Q5EA36#function" }, { "database": "UniProtKB", "id": "Q96PK6", "url": "https://www.uniprot.org/uniprotkb/Q96PK6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA36", "url": "https://www.uniprot.org/uniprotkb/Q5EA36" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RBM14", "url": "https://www.uniprot.org/uniprotkb/Q5EA36", "locus": { "chromosome": "29", "start_pos": 44663023, "end_pos": 44653823, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001225", "url": "https://www.ensembl.org/id/ENSBTAG00000001225" } ] } } ], "crossref": [ { "id": "Q5EA36", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA36", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12608", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12608", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12609", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12609", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511512", "url": "https://www.ncbi.nlm.nih.gov/gene/511512", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "1114000", "url": "https://www.iedb.org/epitope/1114000", "database": "IEDB", "categories": [ "Other" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034506", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034506", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034507", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034507", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511512", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511512", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5EA36", "url": "https://www.orthodb.org/?gene=Q5EA36", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23147", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23147", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PR:Q5EA36", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:Q5EA36", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001014901", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014901", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EA36", "url": "https://www.uniprot.org/uniprotkb/Q5EA36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA36-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA36-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKIFVGNVDGADTTPEELAALFAPYGTVMSCAVMKQFAFVHMRENAGAVRAIEALHGHELRPGRALVVEMSRPRPLNTWKIFVGNVSAACTSQELRSLFERRGRVIECDVVKDYAFVHMEKEADAKAAIAQLNGKEVKGKRINVELSTKGQKKGPGLAIQSGDKTKKPGAGDTAFPGTGGFSATFDYQQAFGNSTGGFDGQARQPTPPFFGRDRSPLRRSPPRASYVAPLTAQPATYRAQPSVSLGAAYRAQPSASLGVGYRTQPMTAQAASYRAQPSVSLGAPYRGQLASPSSQSAAASSLGPYGGAQPSASALSSYGGQPAAASSLNSYGAQGSSLASYGNQPSSYGAQAASSYGVRAAASSYNTQGAANSLGSYGAQAASYGAQSAASSLAYGAQAASYNAQPSASYNAQSAPYAAQQAASYSSQPAAYVAQPATAAAYASQPAAYAAQATTPMAGSYGAQPVVQTQLNSYGAQASMGLSGSYGAQSAAAATGSYGAAAAYGAQPSATLAAPYRTQSSASLAASYAAQQHPQAAASYRGQPGNAYDGTGQPSAAYLSMSQGVVANANSTPPPYERTRLSPPRASYDDPYKKAVAMSKRYGSDRRLAELSDYRRLSESQLSFRRSPTKSSLDYRRLPDAHSDYARYSGSYNDYLRAAQMHSGYQRRM", "length": 669, "header": "sp|Q5EA36-1|RBM14_BOVIN Isoform 1 of RNA-binding protein 14 OS=Bos taurus OX=9913 GN=RBM14 PE=2 SV=1 CANONICAL=Q5EA36-1" }, "isoforms": [ { "isoform_ac": "Q5EA36-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA36/entry#Q5EA36-1", "sequence": { "sequence": "MKIFVGNVDGADTTPEELAALFAPYGTVMSCAVMKQFAFVHMRENAGAVRAIEALHGHELRPGRALVVEMSRPRPLNTWKIFVGNVSAACTSQELRSLFERRGRVIECDVVKDYAFVHMEKEADAKAAIAQLNGKEVKGKRINVELSTKGQKKGPGLAIQSGDKTKKPGAGDTAFPGTGGFSATFDYQQAFGNSTGGFDGQARQPTPPFFGRDRSPLRRSPPRASYVAPLTAQPATYRAQPSVSLGAAYRAQPSASLGVGYRTQPMTAQAASYRAQPSVSLGAPYRGQLASPSSQSAAASSLGPYGGAQPSASALSSYGGQPAAASSLNSYGAQGSSLASYGNQPSSYGAQAASSYGVRAAASSYNTQGAANSLGSYGAQAASYGAQSAASSLAYGAQAASYNAQPSASYNAQSAPYAAQQAASYSSQPAAYVAQPATAAAYASQPAAYAAQATTPMAGSYGAQPVVQTQLNSYGAQASMGLSGSYGAQSAAAATGSYGAAAAYGAQPSATLAAPYRTQSSASLAASYAAQQHPQAAASYRGQPGNAYDGTGQPSAAYLSMSQGVVANANSTPPPYERTRLSPPRASYDDPYKKAVAMSKRYGSDRRLAELSDYRRLSESQLSFRRSPTKSSLDYRRLPDAHSDYARYSGSYNDYLRAAQMHSGYQRRM", "length": 669, "header": "sp|Q5EA36-1|RBM14_BOVIN Isoform 1 of RNA-binding protein 14 OS=Bos taurus OX=9913 GN=RBM14 PE=2 SV=1 CANONICAL=Q5EA36-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 161, "end_pos": 161, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA36", "url": "https://www.uniprot.org/uniprotkb/Q5EA36" } ], "site_lbl": "Ser161" }, { "start_pos": 206, "end_pos": 206, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA36", "url": "https://www.uniprot.org/uniprotkb/Q5EA36" } ], "site_lbl": "Thr206" }, { "start_pos": 220, "end_pos": 220, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA36", "url": "https://www.uniprot.org/uniprotkb/Q5EA36" } ], "site_lbl": "Ser220" }, { "start_pos": 242, "end_pos": 242, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA36", "url": "https://www.uniprot.org/uniprotkb/Q5EA36" } ], "site_lbl": "Ser242" }, { 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"count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA62-1", "uniprot_ac": "Q5EA62", "uniprot_id": "FBLN5_BOVIN", "mass": { "chemical_mass": 50164.0, "monoisotopic_mass": 50164.0 }, "refseq": { "ac": "NP_001014946", "name": "fibulin-5 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014946" }, "gene_names": [ { "name": "FBLN5", "type": "recommended", "evidence": [ { "id": "Q5EA62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA62" } ] }, { "name": "FBLN5", "type": "synonym", "evidence": [ { "id": "NP_001014946", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014946" } ] } ], "protein_names": [ { "name": "Fibulin-5", "type": "recommended", "evidence": [ { "id": "Q5EA62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA62/entry#names_and_taxonomy" } ] }, { "name": "FIBL-5", "type": "synonym", "evidence": [ { "id": "NP_001014946", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014946" }, { "id": "Q5EA62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA62/entry#names_and_taxonomy" } ] }, { "name": "fibulin-5 precursor", "type": "synonym", "evidence": [ { "id": "NP_001014946", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014946" } ] } ], "function": [ { "annotation": "Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN.", "evidence": [ { "database": "UniProtKB", "id": "Q5EA62", "url": "https://www.uniprot.org/uniprotkb/Q5EA62#function" }, { "database": "UniProtKB", "id": "Q9WVH9", "url": "https://www.uniprot.org/uniprotkb/Q9WVH9#function" }, { "database": "UniProtKB", "id": "Q9UBX5", "url": "https://www.uniprot.org/uniprotkb/Q9UBX5#function" } ] }, { "annotation": "These results suggest a novel regulatory mechanism of elastic fiber assembly in which LTBP-2 regulates targeting of DANCE on suitable microfibrils to form elastic fibers.", "evidence": [ { "database": "RefSeq", "id": "NP_001014946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014946" }, { "database": "PubMed", "id": "17581631", "url": "https://glygen.org/publication/PubMed/17581631" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { 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"id": "IPR049883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052235", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052235", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535185", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535185", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5EA62", "url": "https://www.orthodb.org/?gene=Q5EA62", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24050", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24050", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24050:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24050:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07645", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07645", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12662", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12662", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22914", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22914", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014946", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EA62", "url": "https://www.uniprot.org/uniprotkb/Q5EA62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA62-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA62-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGFKRILTVTVLALCLPTPGNAQQQCTNGFDLDRSSGQCLDVDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSNPYSASYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEDDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPAGYILLDDNRSCQDINECEHRNHTCILQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNDGREFYMRQTGPISATLVMTRPIKGPRDIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF", "length": 448, "header": "sp|Q5EA62-1|FBLN5_BOVIN Isoform 1 of Fibulin-5 OS=Bos taurus OX=9913 GN=FBLN5 PE=2 SV=1 CANONICAL=Q5EA62-1" }, "isoforms": [ { "isoform_ac": "Q5EA62-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA62/entry#Q5EA62-1", "sequence": { "sequence": "MPGFKRILTVTVLALCLPTPGNAQQQCTNGFDLDRSSGQCLDVDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSNPYSASYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEDDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPAGYILLDDNRSCQDINECEHRNHTCILQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNDGREFYMRQTGPISATLVMTRPIKGPRDIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF", "length": 448, "header": "sp|Q5EA62-1|FBLN5_BOVIN Isoform 1 of Fibulin-5 OS=Bos taurus OX=9913 GN=FBLN5 PE=2 SV=1 CANONICAL=Q5EA62-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 19, "start_aa": "Thr", "end_pos": 19, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr19", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 283, "start_aa": "Asn", "end_pos": 283, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn283", "evidence": [ { "id": "Q5EA62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA62#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 296, "start_aa": "Asn", "end_pos": 296, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn296", "evidence": [ { "id": "Q5EA62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA62#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA62", "url": "https://www.uniprot.org/uniprotkb/Q5EA62" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "Latent TGF-beta-binding protein 2 binds to DANCE/fibulin-5 and regulates elastic fiber assembly.", "journal": "The EMBO journal", "date": "2007-07-25", "authors": "Hirai Maretoshi, Horiguchi Masahito, Ohbayashi Tetsuya, Kita Toru, Chien Kenneth R, Nakamura Tomoyuki", "evidence": [ { "database": "RefSeq", "id": "NP_001014946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014946" } ], "reference": [ { "type": "PubMed", "id": "17581631", "url": "https://glygen.org/publication/PubMed/17581631" } ] } ], "pathway": [ { "id": "bta:535185", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535185", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "integrin binding", "id": "GO:0005178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005178", "evidence": [ { "database": "UniProtKB", "id": "Q5EA62", "url": "https://www.uniprot.org/uniprotkb/Q5EA62" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q5EA62", "url": 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"evidence": [ { "database": "UniProtKB", "id": "Q5EA62", "url": "https://www.uniprot.org/uniprotkb/Q5EA62" } ], "pmid": "" }, { "name": "elastic fiber assembly", "id": "GO:0048251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048251", "evidence": [ { "database": "UniProtKB", "id": "Q5EA62", "url": "https://www.uniprot.org/uniprotkb/Q5EA62" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 296, "end_pos": 298, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA62-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 448, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA62-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA62" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5EA62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA62" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Cell attachment site", "eco_id": "ECO_0000255", "start_pos": 54, "end_pos": 56, "start_aa": "Arg", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5EA62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA62" }, { "id": "PRU00076", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00076" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like 1; calcium-binding", "eco_id": "ECO_0000255", "start_pos": 42, "end_pos": 82, "start_aa": "Asp", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5EA62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA62" }, { "id": "PRU00076", "database": "PROSITE", "url": 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"sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA66-1", "uniprot_ac": "Q5EA66", "uniprot_id": "ANGL7_BOVIN", "mass": { "chemical_mass": 39457.0, "monoisotopic_mass": 39457.0 }, "refseq": { "ac": "NP_001014909", "name": "angiopoietin-related protein 7 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014909" }, "gene_names": [ { "name": "ANGPTL7", "type": "recommended", "evidence": [ { "id": "Q5EA66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA66" } ] }, { "name": "ANGPTL7", "type": "synonym", "evidence": [ { "id": "NP_001014909", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014909" } ] } ], "protein_names": [ { "name": "Angiopoietin-related protein 7", "type": "recommended", "evidence": [ { "id": "Q5EA66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA66/entry#names_and_taxonomy" } ] }, { "name": "Angiopoietin-like protein 7", "type": "synonym", "evidence": [ { "id": "Q5EA66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA66/entry#names_and_taxonomy" } ] }, { "name": "angiopoietin-like protein 7", "type": "synonym", "evidence": [ { "id": "NP_001014909", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014909" } ] }, { "name": "angiopoietin-related protein 7 precursor", "type": "synonym", "evidence": [ { "id": "NP_001014909", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014909" } ] }, { "name": "angiopoietin-related protein 7", "type": "synonym", "evidence": [ { "id": "NP_001014909", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014909" } ] } ], "function": [ { "annotation": "Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure. Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency.", "evidence": [ { "database": "UniProtKB", "id": "Q5EA66", "url": "https://www.uniprot.org/uniprotkb/Q5EA66#function" }, { "database": "UniProtKB", "id": "O43827", "url": "https://www.uniprot.org/uniprotkb/O43827#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA66", "url": "https://www.uniprot.org/uniprotkb/Q5EA66" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANGPTL7", "url": "https://www.uniprot.org/uniprotkb/Q5EA66", "locus": { "chromosome": "16", "start_pos": 42447039, "end_pos": 42453123, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015340", "url": "https://www.ensembl.org/id/ENSBTAG00000015340" } ] } } ], "crossref": [ { "id": "Q5EA66", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA66", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015340", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015340", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00087", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00087", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512698", "url": "https://www.ncbi.nlm.nih.gov/gene/512698", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512698", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512698", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GWHGANY", "url": "https://omabrowser.org/oma/group/GWHGANY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EA66", "url": "https://www.orthodb.org/?gene=Q5EA66", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47221", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47221", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47221:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47221:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00147", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00147", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014909", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014909", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EA66", "url": "https://www.uniprot.org/uniprotkb/Q5EA66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA66-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA66-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLKKTLSAVAWLCIFLVAFVSHPVWPQKPPKRKTPAELTAATCCEEAKALQAQIANLSSLLSDLGKKQERDWVSVVMQVMELESSAKSMETRLTEAESKYSEMNNQIGIMQLQAAQTVTQTSADAIYDCSSLYQKNYRISGVYKLPPDDFLGSPELEVFCDMETSGGGWTIIQRRKSGLVSFYRDWKQYKQGFGSIRGDFWLGNDHIHRLSRRPTRLRVEMQDWEGNMRYAEYSHFVLGNELNSYRLFLGNYSGDVGNDALIYHNNTAFSTKDKDNDNCLDKCAQLRKGGYWYNCCTDSNLNGVYYRLGEHNKHLDGITWYGWHGSSYSLKRVEMKIRPEDFQP", "length": 344, "header": "sp|Q5EA66-1|ANGL7_BOVIN Isoform 1 of Angiopoietin-related protein 7 OS=Bos taurus OX=9913 GN=ANGPTL7 PE=2 SV=1 CANONICAL=Q5EA66-1" }, "isoforms": [ { "isoform_ac": "Q5EA66-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA66/entry#Q5EA66-1", "sequence": { "sequence": "MLKKTLSAVAWLCIFLVAFVSHPVWPQKPPKRKTPAELTAATCCEEAKALQAQIANLSSLLSDLGKKQERDWVSVVMQVMELESSAKSMETRLTEAESKYSEMNNQIGIMQLQAAQTVTQTSADAIYDCSSLYQKNYRISGVYKLPPDDFLGSPELEVFCDMETSGGGWTIIQRRKSGLVSFYRDWKQYKQGFGSIRGDFWLGNDHIHRLSRRPTRLRVEMQDWEGNMRYAEYSHFVLGNELNSYRLFLGNYSGDVGNDALIYHNNTAFSTKDKDNDNCLDKCAQLRKGGYWYNCCTDSNLNGVYYRLGEHNKHLDGITWYGWHGSSYSLKRVEMKIRPEDFQP", "length": 344, "header": "sp|Q5EA66-1|ANGL7_BOVIN Isoform 1 of Angiopoietin-related protein 7 OS=Bos taurus OX=9913 GN=ANGPTL7 PE=2 SV=1 CANONICAL=Q5EA66-1" }, "locus": { "chromosome": "16", "start_pos": 42452696, "end_pos": 42447934, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020392.3", "url": "https://www.ensembl.org/id/ENSBTAT00000020392.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020392.2", "url": "https://www.ensembl.org/id/ENSBTAP00000020392.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 251, "start_aa": "Asn", "end_pos": 251, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn251", "evidence": [ { "id": "Q5EA66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA66#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 265, "start_aa": "Asn", "end_pos": 265, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn265", "evidence": [ { "id": "Q5EA66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA66#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 56, "start_aa": "Asn", "end_pos": 56, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn56", "evidence": [ { "id": "Q5EA66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA66#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA66", "url": "https://www.uniprot.org/uniprotkb/Q5EA66" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:512698", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512698", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZDK4-1", "protein_name": "Angiopoietin like 7", "gene_name": "Angptl7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLPWWGIQTWEGKVFKYPPSSVSETPALRKAHRGRRPRGRKKTALVSQTLSFLVLLNTDSRRKTCPRGLHTMLRTTWLCILLVASVSRPVWLQKPHKRKTQLKAAGCCEEMRELKAQVANLSSLLGELSRKQESDWVSVVMQVMELESSSKRMESRLTTAESKYSEMNNQIDIMQLQAAQTVTQTSADAIYDCSSLYQKNYRISGVYKLPPDEFLGSPELEVFCDMETSGGGWTIIQRRKSGLVSFYQDWKQYKQGFGSIRGDFWLGNEHIHRLTRQPTRLRVELEDWEGNARYAEYSYFALGNELNSYRLFLGNYSGNVGKDALLYHNNTVFSTKDKDNDNCLDKCAQLRKGGYWYNCCTDSNLNGVYYRLGEHRKHMDGISWYGWHGANYSLKRVEMKIRPEAFTP", "length": 408 }, "evidence": [ { "id": "Q5EA66", "url": "https://omabrowser.org/oma/group/Q5EA66/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O43827-1", "protein_name": "Angiopoietin-related protein 7", "gene_name": "ANGPTL7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLKKPLSAVTWLCIFIVAFVSHPAWLQKLSKHKTPAQPQLKAANCCEEVKELKAQVANLSSLLSELNKKQERDWVSVVMQVMELESNSKRMESRLTDAESKYSEMNNQIDIMQLQAAQTVTQTSADAIYDCSSLYQKNYRISGVYKLPPDDFLGSPELEVFCDMETSGGGWTIIQRRKSGLVSFYRDWKQYKQGFGSIRGDFWLGNEHIHRLSRQPTRLRVEMEDWEGNLRYAEYSHFVLGNELNSYRLFLGNYTGNVGNDALQYHNNTAFSTKDKDNDNCLDKCAQLRKGGYWYNCCTDSNLNGVYYRLGEHNKHLDGITWYGWHGSTYSLKRVEMKIRPEDFKP", "length": 346 }, "evidence": [ { "id": "Q5EA66", "url": "https://omabrowser.org/oma/group/Q5EA66/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R1Q3-1", "protein_name": "Angiopoietin-related protein 7", "gene_name": "Angptl7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRETWLCVILVAFVSHPVWLQKPHKRKTQLKAAGCCEEMRELKAQVANLSSLLGELSRKQESDWVSVVMQVMELESSSKHMESRLSTAESKYSEMNNQIDIMQLQAAQTVTQTSADAIYDCSSLYQKNYRISGVYKLPPDEFLGSPELEVFCDMETSGGGWTIIQRRKSGLVSFYQDWRQYKQGFGSIRGDFWLGNEHIHRLTRQPSRLRVELEDWEGNARYAEYSYFALGNELNSYRLFLGNYSGNVGKDALLYHNNTVFSTKDKDNDNCLDKCAQLRKGGYWYNCCTDSNLNGVYYRLGEHRKHMDGISWYGWHGANYSLKRVEMKIRPEAFKP", "length": 337 }, "evidence": [ { "id": "Q5EA66", "url": "https://omabrowser.org/oma/group/Q5EA66/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q5EA66", "url": "https://www.uniprot.org/uniprotkb/Q5EA66" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q5EA66", "url": "https://www.uniprot.org/uniprotkb/Q5EA66" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "Q5EA66", "url": "https://www.uniprot.org/uniprotkb/Q5EA66" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q5EA66", "url": "https://www.uniprot.org/uniprotkb/Q5EA66" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "blood coagulation", "id": "GO:0007596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596", "evidence": [ { "database": "UniProtKB", "id": "Q5EA66", "url": "https://www.uniprot.org/uniprotkb/Q5EA66" } ], "pmid": "" }, { "name": "regulation of extracellular matrix organization", "id": "GO:1903053", "url": 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[], "sequon_annotation_sites": [ { "start_pos": 251, "end_pos": 253 }, { "start_pos": 265, "end_pos": 267 }, { "start_pos": 56, "end_pos": 58 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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"count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA77-1", "uniprot_ac": "Q5EA77", "uniprot_id": "SNX17_BOVIN", "mass": { "chemical_mass": 52825.0, "monoisotopic_mass": 52825.0 }, "refseq": { "ac": "NP_001015638", "name": "sorting nexin-17", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015638" }, "gene_names": [ { "name": "SNX17", "type": "recommended", "evidence": [ { "id": "Q5EA77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ] }, { "name": "SNX17", "type": "synonym", "evidence": [ { "id": "NP_001015638", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015638" } ] } ], "protein_names": [ { "name": "Sorting nexin-17", "type": "recommended", "evidence": [ { "id": "Q5EA77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA77/entry#names_and_taxonomy" } ] }, { "name": "sorting nexin-17", "type": "synonym", "evidence": [ { "id": "NP_001015638", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015638" } ] } ], "function": [ { "annotation": "Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (By similarity). Binds to NPxY sequences in the cytoplasmic tails of target cargos (By similarity). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (By similarity). Also required for maintenance of normal cell surface levels of APP and LRP1 (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77#function" }, { "database": "UniProtKB", "id": "Q8BVL3", "url": "https://www.uniprot.org/uniprotkb/Q8BVL3#function" }, { "database": "UniProtKB", "id": "Q15036", "url": "https://www.uniprot.org/uniprotkb/Q15036#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNX17", "url": "https://www.uniprot.org/uniprotkb/Q5EA77", "locus": { "chromosome": "11", "start_pos": 72286895, "end_pos": 72292726, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019515", "url": "https://www.ensembl.org/id/ENSBTAG00000019515" } ] } } ], "crossref": [ { "id": "Q5EA77", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA77", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019515", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019515", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06885", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06885", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13337", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13337", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16121", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16121", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "529972", "url": "https://www.ncbi.nlm.nih.gov/gene/529972", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037836", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037836", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040842", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040842", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048767", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048767", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529972", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529972", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RRHCVGV", "url": "https://omabrowser.org/oma/group/RRHCVGV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EA77", "url": "https://www.orthodb.org/?gene=Q5EA77", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12431", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12431", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12431:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12431:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18116", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18116", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21273", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21273", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001015638", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015638", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA77-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA77-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVADIERGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGGTSSPGRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLESPDASRESMVKLSSKLSAVSLRGIGTPGTDASASDVHGNFAFEGIGDEDL", "length": 470, "header": "sp|Q5EA77-1|SNX17_BOVIN Isoform 1 of Sorting nexin-17 OS=Bos taurus OX=9913 GN=SNX17 PE=2 SV=1 CANONICAL=Q5EA77-1" }, "isoforms": [ { "isoform_ac": "Q5EA77-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA77/entry#Q5EA77-1", "sequence": { "sequence": "MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVADIERGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGGTSSPGRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLESPDASRESMVKLSSKLSAVSLRGIGTPGTDASASDVHGNFAFEGIGDEDL", "length": 470, "header": "sp|Q5EA77-1|SNX17_BOVIN Isoform 1 of Sorting nexin-17 OS=Bos taurus OX=9913 GN=SNX17 PE=2 SV=1 CANONICAL=Q5EA77-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 336, "end_pos": 336, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "site_lbl": "Ser336" }, { "start_pos": 407, "end_pos": 407, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "site_lbl": "Ser407" }, { "start_pos": 409, "end_pos": 409, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "site_lbl": "Ser409" }, { "start_pos": 415, "end_pos": 415, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "site_lbl": "Ser415" }, { "start_pos": 421, "end_pos": 421, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "site_lbl": "Ser421" }, { "start_pos": 437, "end_pos": 437, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "site_lbl": "Ser437" }, { "start_pos": 440, "end_pos": 440, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "site_lbl": "Ser440" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:529972", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529972", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Y440-1", "protein_name": "Sorting nexin-17", "gene_name": "SNX17", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MHFSIPETETRAGDGGAAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGTNVVPAFPPKKIFTLTPAEVEQRREQLEKYMQAVRQDPTLGGSETFNSFLRKAQQETQQIPTEEVVLEVLLSNGQKVKVTILTSDQTEDVLEAVASKLDLPDDLVGYFSLFLVRETKDGAFSFVRKLQEFELPYVSVTSLHNPEFRIILRKSYWDSSYDDDVMEHHVGLNLLYAQTVSDIEHGWILVNKEQHRQLKSLQEKVSKKEFIRLAQTLKYYGYLKFDPCVTDFPEKGCHVVVSAGNNELNFQVRLPSEQIKEGSFKVTRMRCWRVTSSLVSVQVPMSNGPSGSSPGKSEVKLELAFEYLMSKDRLQWVTITSPQAIMLSICLQSMVDELMVKKSGGSIRKMFRRRANGALRRSDSQQAVKSPPLLDSPDASREPMAKLSSKLTSVSLRGISHSSSANDVGANDFHGNYAFEGIGDEDL", "length": 475 }, "evidence": [ { "id": "Q5EA77", "url": "https://omabrowser.org/oma/group/Q5EA77/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3GXT9-1", "protein_name": "Sorting nexin-17", "gene_name": "Snx17", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGSFSFVRKLQEFELPYVSVTSLRNHEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIEHGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGGPSSPSQGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLKRSDSQQAVKSPPLLESPDASRESMVKLSSKLSAVSLRGIGSPSTDASASAVHGNFAFEGIGDEDL", "length": 470 }, "evidence": [ { "id": "Q5EA77", "url": "https://omabrowser.org/oma/group/Q5EA77/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q15036-1", "protein_name": "Sorting nexin-17", "gene_name": "SNX17", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIERGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGSTSSPGRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLESPDATRESMVKLSSKLSAVSLRGIGSPSTDASASDVHGNFAFEGIGDEDL", "length": 470 }, "evidence": [ { "id": "Q5EA77", "url": "https://omabrowser.org/oma/group/Q5EA77/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5RID7-1", "protein_name": "Sorting nexin-17", "gene_name": "snx17", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MHFSIPETEVRSDENGSSYVAYNIHVNGVLHCRVRYSQLLGLHEQIKKEYGNNVVPAFPPKKIFTLTPAEVDQRREQLEKYMQAVRQDPILGSSEMFNSFLRKAQQETQQIPTEEVQLEIYLSNGQKVKVNILTSDQTEDVLEAVASKLDLPDELVGYFSLFLVQERADGSCTYVRKLQEFELPYVSITSLHSSDYRIILRKSYWDTAYDSDVMDDRVGLNLLYAQTVSDIDRGWILVNKEQHRQLKSLQEKGSKKEFIRLAQTLKYYGYIKFDPCITDFPEKGCHVIVGAGNNELNFHVKLPNEQMKEGSFKVTRMRCWRVTSSQVPVANGTANPSSSSKCDVKLELAFEYLMSKDRLQWVTITSQQAIMMSICLQSMVDELMVKKSGGSIKKQMQKKRLNGSLQRSDSQQAVKSPPILDSPDPNREQVVKLSTKLSSVSLRGLSSSNSAGDISGNDFHGNYAFEGIGDDDL", "length": 473 }, "evidence": [ { "id": "Q5EA77", "url": "https://omabrowser.org/oma/group/Q5EA77/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6AYS6-1", "protein_name": "Sorting nexin-17", "gene_name": "Snx17", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHFSIPETESRSGDSGGSTYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSDGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIEHGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGGTSTPSRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGNLRRSDSQQAVKSPPLLESPDASRESMVKLSSKLSAVSLRGIGSPSTDASASAVHGNFAFEGIGDEDL", "length": 470 }, "evidence": [ { "id": "Q5EA77", "url": "https://omabrowser.org/oma/group/Q5EA77/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BVL3-1", "protein_name": "Sorting nexin-17", "gene_name": "Snx17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVVPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLVTVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIEHGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGGTSSPSRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLESPDASRESMVKLSSKLSAVSLRGIGSPSTDASASAVHGNFAFEGIGDEDL", "length": 470 }, "evidence": [ { "id": "Q5EA77", "url": "https://omabrowser.org/oma/group/Q5EA77/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VL28-1", "protein_name": "Sorting nexin 17", "gene_name": "Snx17", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MHSSRMHFSIPDTQELGSSPTYTAYNIHINGIHHCVLRYKQLHSLNDQLRRHCVGVPLPPFPPKRLLPLTNGQLEARRSSLEQYLQAVGQDNRLARSAHLQQFLQRAQLDTALAEGQVATDCEEQQLEVQVYTNPAGERILVNCSVQQNASALLKSVCRELQLPDELVRFFCLFLVRRQRKSGELHLVRRLMDFESPYITRLHVQPCELLLRTCYWDSSRDAKLTGSKVALNLLYNQTVADVNREWVVICTPGEGRQLNSLQMQGRAREYMDLVRQLPSYGCLQFDEAQVDYPEPDTMALISIGNKELALRTARGVKIYETKFRVTRMRSWRVSVTHITLESRLEPTHLQLAFEYLIGKQTLRWITINSDQAMLMSVCLQAMVDELLQRGAGSGKDQNSDEEQEQNAVTSSSSTPSSTCSTSTWASSTCSTSTAPTTPPVRFLSEDSAPRSKPRLTTSRTFGAVFFRNDVVDNGARVANGAFEGIGDDDL", "length": 490 }, "evidence": [ { "id": "Q5EA77", "url": "https://omabrowser.org/oma/group/Q5EA77/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "pmid": "" }, { "name": "receptor-mediated endocytosis", "id": "GO:0006898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006898", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "pmid": "" }, { "name": "endocytic recycling", "id": "GO:0032456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032456", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "Q5EA77", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA77-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 470, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA77-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA77" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5EA77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" }, { "id": "PRU00147", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00147" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PX", "eco_id": "ECO_0000255", "start_pos": 1, "end_pos": 109, "start_aa": "Met", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5EA77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA77" }, { "id": "PRU00166", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00166" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ras-associating", "eco_id": "ECO_0000255", "start_pos": 115, "end_pos": 206, "start_aa": "Glu", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 336, 407, 409, 415, 421, 437, 440 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EA84-1", "uniprot_ac": "Q5EA84", "uniprot_id": "DOK1_BOVIN", "mass": { "chemical_mass": 52206.0, "monoisotopic_mass": 52206.0 }, "refseq": { "ac": "NP_001019714", "name": "docking protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019714" }, "gene_names": [ { "name": "DOK1", "type": "recommended", "evidence": [ { "id": "Q5EA84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA84" } ] }, { "name": "DOK1", "type": "synonym", "evidence": [ { "id": "NP_001019714", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019714" } ] } ], "protein_names": [ { "name": "Docking protein 1", "type": "recommended", "evidence": [ { "id": "Q5EA84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA84/entry#names_and_taxonomy" } ] }, { "name": "Downstream of tyrosine kinase 1", "type": "synonym", "evidence": [ { "id": "Q5EA84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA84/entry#names_and_taxonomy" } ] }, { "name": "docking protein 1", "type": "synonym", "evidence": [ { "id": "NP_001019714", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019714" } ] }, { "name": "downstream of tyrosine kinase 1", "type": "synonym", "evidence": [ { "id": "NP_001019714", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019714" } ] } ], "function": [ { "annotation": "DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5EA84", "url": "https://www.uniprot.org/uniprotkb/Q5EA84#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EA84", "url": "https://www.uniprot.org/uniprotkb/Q5EA84" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DOK1", "url": "https://www.uniprot.org/uniprotkb/Q5EA84", "locus": { "chromosome": "11", "start_pos": 10085663, "end_pos": 10103196, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018579", "url": "https://www.ensembl.org/id/ENSBTAG00000018579" } ] } } ], "crossref": [ { "id": "Q5EA84", "url": "https://alphafold.ebi.ac.uk/entry/Q5EA84", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01203", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01203", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14676", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14676", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514962", "url": "https://www.ncbi.nlm.nih.gov/gene/514962", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050996", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050996", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514962", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514962", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5EA84", "url": "https://www.orthodb.org/?gene=Q5EA84", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21258", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21258", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21258:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21258:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02174", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02174", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001019714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019714", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EA84", "url": "https://www.uniprot.org/uniprotkb/Q5EA84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EA84-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA84-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRLDCKVIRLAECVSVAPVAVESPPEPGAASFRLDTAQRSHLLAADAPSSAAWVQTLCQNAFPKGSWALAPAENPPKLSALEMLENSLYSPSWEGSQFWVTVQKTEAAERCGLHGSYVLRVEAERLTLLAPGAQRQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVETAIHRQKIQGKAGQGQDVLRADSHEGEVADGKLASLAAPLELPGSPPALYSEPLDSLRIPPGPSQDSLYSDPLDSTPARAGEGTQLKKALYWDLCEHVQQKLIKAKLTDPKEDPIYDEPEGLAPATLRGLYDLPQEPKDAWWCQARVKEEGYELPYNPAMDDYAVPPPRSTKPFPAPKPQGLALSESGAATGSGSQGHSSDTALYSQVQKSGASGSWDCGLSGVVTDRTGAKSEGST", "length": 483, "header": "sp|Q5EA84-1|DOK1_BOVIN Isoform 1 of Docking protein 1 OS=Bos taurus OX=9913 GN=DOK1 PE=2 SV=1 CANONICAL=Q5EA84-1" }, "isoforms": [ { "isoform_ac": "Q5EA84-1", "url": "https://www.uniprot.org/uniprotkb/Q5EA84/entry#Q5EA84-1", "sequence": { "sequence": "MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRLDCKVIRLAECVSVAPVAVESPPEPGAASFRLDTAQRSHLLAADAPSSAAWVQTLCQNAFPKGSWALAPAENPPKLSALEMLENSLYSPSWEGSQFWVTVQKTEAAERCGLHGSYVLRVEAERLTLLAPGAQRQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVETAIHRQKIQGKAGQGQDVLRADSHEGEVADGKLASLAAPLELPGSPPALYSEPLDSLRIPPGPSQDSLYSDPLDSTPARAGEGTQLKKALYWDLCEHVQQKLIKAKLTDPKEDPIYDEPEGLAPATLRGLYDLPQEPKDAWWCQARVKEEGYELPYNPAMDDYAVPPPRSTKPFPAPKPQGLALSESGAATGSGSQGHSSDTALYSQVQKSGASGSWDCGLSGVVTDRTGAKSEGST", "length": 483, "header": "sp|Q5EA84-1|DOK1_BOVIN Isoform 1 of Docking protein 1 OS=Bos taurus OX=9913 GN=DOK1 PE=2 SV=1 CANONICAL=Q5EA84-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 322, "start_aa": 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"site_lbl": "Tyr296" }, { "start_pos": 337, "end_pos": 337, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA84", "url": "https://www.uniprot.org/uniprotkb/Q5EA84" } ], "site_lbl": "Tyr337" }, { "start_pos": 362, "end_pos": 362, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA84", "url": "https://www.uniprot.org/uniprotkb/Q5EA84" } ], "site_lbl": "Tyr362" }, { "start_pos": 377, "end_pos": 377, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA84", "url": "https://www.uniprot.org/uniprotkb/Q5EA84" } ], "site_lbl": "Tyr377" }, { "start_pos": 398, "end_pos": 398, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": 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"Q5EA98", "url": "https://www.uniprot.org/uniprotkb/Q5EA98" } ], "site_lbl": "Ser132" }, { "start_pos": 133, "end_pos": 133, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA98", "url": "https://www.uniprot.org/uniprotkb/Q5EA98" } ], "site_lbl": "Ser133" }, { "start_pos": 267, "end_pos": 267, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA98", "url": "https://www.uniprot.org/uniprotkb/Q5EA98" } ], "site_lbl": "Thr267" }, { "start_pos": 361, "end_pos": 361, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA98", "url": "https://www.uniprot.org/uniprotkb/Q5EA98" } ], "site_lbl": "Ser361" }, { "start_pos": 432, "end_pos": 432, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA98", "url": "https://www.uniprot.org/uniprotkb/Q5EA98" } ], "site_lbl": "Ser432" }, { "start_pos": 52, "end_pos": 52, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA98", "url": "https://www.uniprot.org/uniprotkb/Q5EA98" } ], "site_lbl": "Ser52" }, { "start_pos": 53, "end_pos": 53, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA98", "url": "https://www.uniprot.org/uniprotkb/Q5EA98" } ], "site_lbl": "Ser53" }, { "start_pos": 94, "end_pos": 94, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EA98", "url": "https://www.uniprot.org/uniprotkb/Q5EA98" } ], "site_lbl": "Ser94" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EA98", "url": "https://www.uniprot.org/uniprotkb/Q5EA98" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:510905", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510905", "resource": "KEGG Pathway" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VC88-1", "protein_name": "Microfibril associated protein 1", "gene_name": "MFAP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSVPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDTSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRDFSAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDTTSFDSAWGQESAQNTKFFKQKAAGVRDVFERPSAKKRKTT", "length": 439 }, "evidence": [ { "id": "Q5EA98", "url": "https://omabrowser.org/oma/group/Q5EA98/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I5ZMN0-1", "protein_name": "Microfibrillar-associated protein 1A like 1", "gene_name": "Mfap1al1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSVPSTLMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRDFSAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDTTSFDSAWGQESAQNTKFFKQKAAGVRDVFERPSAKKRKTT", "length": 438 }, "evidence": [ { "id": "Q5EA98", "url": "https://omabrowser.org/oma/group/Q5EA98/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "C0HKD8-1", "protein_name": "Microfibrillar-associated protein 1A", "gene_name": "Mfap1a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRLEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKREREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRDFSAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDTTSFDSAWGQESAQNTKFFKQKAAGVRDVFERPSAKKRKTT", "length": 439 }, "evidence": [ { "id": "Q5EA98", "url": "https://omabrowser.org/oma/group/Q5EA98/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "C0HKD9-1", "protein_name": "Microfibrillar-associated protein 1B", "gene_name": "Mfap1b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRLEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKREREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRDFSAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDTTSFDSAWGQESAQNTKFFKQKAAGVRDVFERPSAKKRKTT", "length": 439 }, "evidence": [ { "id": "Q5EA98", "url": "https://omabrowser.org/oma/group/Q5EA98/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "G3H0T7-1", "protein_name": "Microfibrillar-associated protein 1", "gene_name": "Mfap1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSVPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMELEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRDFSAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDTTSFDSAWGQESAQNTKFFKQKAAGVRDVFERPSAKKRKTT", "length": 439 }, "evidence": [ { "id": "Q5EA98", "url": "https://omabrowser.org/oma/group/Q5EA98/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O22281-1", "protein_name": "Microfibrillar-associated protein-like protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSVTAGVSESAIAVREKLKGGIGQTKVRRYWPGKAPEWAEEAEEDDDVRMQKFSVLDRAFPKNDDLGVARKDDPRLRRLAQTKVENRDEVRADHRRIRQAEIISTEEEESRNQENRDEDDDEDALEERRRRIKEKNLRRAQEEAALLPLEEEDEIQEEEEEEEESEYETDSEDDMPGIALIKPVFVPKAERDTIAERERLEAEEEALEELAKRKLEQRKIETKQIVVEEVRKDEEIRKNILLEEANIGDVETDDELNEAEEYEVWKTREIGRIKRERDAREAMLREREEIEKLRNMTEQERRDWERKNPKPSSAQPKKKWNFMQKYYHKGAFFQADPDDEAGSAGTDGIFQRDFSAPTGEDRLDKSILPKVMQVKHFGRSGRTKWTHLVNEDTTDWSNPWTSNDPLREKYNKKMAGMDAPIAKPKGSKKMKDWET", "length": 435 }, "evidence": [ { "id": "Q5EA98", "url": "https://omabrowser.org/oma/group/Q5EA98/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P55081-1", "protein_name": "Microfibrillar-associated protein 1", "gene_name": "MFAP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSVPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRDFSAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDTTSFDSAWGQESAQNTKFFKQKAAGVRDVFERPSAKKRKTT", "length": 439 }, "evidence": [ { "id": "Q5EA98", "url": "https://omabrowser.org/oma/group/Q5EA98/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54SU3-1", "protein_name": "Protein MFAP1 homolog", "gene_name": "mfap1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSVASRIRDKLKNNLESSGGHSVVTSGTKVIRYRAGQRPDYAEAEDDQDSHFSNIQNQKSIKEAETNDPRLARFKNRSSNQDEPQSVEERKASRRRHHDDDNDNDTTTTTTTTTSRRIQKTEIIKEDDDNNNNNNNDTKKDHNDDDEDDDRRRRAKERYLKKKEEEEQKQKELEEKQQPFKDIEGESEEEGSSEYETDSEEDDEDEYWDQPPIFRPTFIKKDDRGTIKTDEQWEKEEQEQQAQLEREKEQRKIEAHRKLKDELDRDRKEQEAKELEQKEEEEYDDDEDQDGSKKLLWIQRELERVRLEIHTRLLAEFEKKEFARRRAMTDDQILKEDPSRSRTNIDNSQKKQLKFLQRDYHRGAFFQDDEYIKNKDFSAPTGEDKFNRELLPKVMQVKNFGKAGRTKYTHLKDQDTTEKDSLWNTNYNNKKKYNNNNNNSNSNSSNNNRDYNYRDRDNRS", "length": 460 }, "evidence": [ { "id": "Q5EA98", "url": "https://omabrowser.org/oma/group/Q5EA98/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9W062-1", "protein_name": "Microfibrillar-associated protein 1", "gene_name": "Mfap1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSAATAAAAASGIQSTAGAIPMRNEKGELSMQKVKVQRYISGKRPDYARADSSSEESDDDDFIDTRKRLERHKAERHKLELSRQGGSAEGEERAAGEGQEEDDAEVDDPRLRRLRQRPVDMEDMERERRERHRHIHEPEIMESDSEDEEEDEGAQGAIQRGTNKITLASESDTDAELSDTELENRRTKLRSRMLQQQREEEVLQKEDEKQSESSESESSEYEEETESEEDNEPRLKPLFVRKRDRATIQEKEREAQKQKQLEAEAKRAAKERRRATLRMVEESVKKDLEKTKPETNEACIEDVCTDDENDEVEYEAWKLRELKRMKRDREERDNVEREKLDIDRMRNMTEEERRQELRQNPKVVTNKATKGKYKFLQKYYHRGAFYLDEENDVLKRDFAQATLEDHFDKTILPKVMQVKNFGRCGRTKYTHLVDQDTTKFDSPWYAESSSNIKFHNEHAGGMRQQFDKPTGSKRKKME", "length": 478 }, "evidence": [ { "id": "Q5EA98", "url": "https://omabrowser.org/oma/group/Q5EA98/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "R4GGG5-1", "protein_name": "Microfibrillar associated protein 1", "gene_name": "MFAP1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSAPSALVKQPPIQSTAGAVPVRNEKGELSMEKVKVKRYVSGKRPDYAPMESSEEEDEEFQFIKKAKEQEVEPEEQEEEVANDPRLRRLQNRITEDVEERLARHRKIVEPEVVGESDSEVEGEAWRVEREDTSEEEEEEIDDEEIERRRGMMRQRAQERKTEELEVMELEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRITVQEREAEALKQKELEQEAKRLAEERRKYTLKIVEEEAKKELEENKRSLAALDALDTDDENDEEEYEAWKVRELKRIKRDREEREAMEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRDFSAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDTTSFDSAWGQESAQNTKFFKQKAAGVRDVFERPSAKKRKTT", "length": 439 }, "evidence": [ { "id": "Q5EA98", "url": "https://omabrowser.org/oma/group/Q5EA98/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5EA98", "url": "https://www.uniprot.org/uniprotkb/Q5EA98" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q5EA98", "url": "https://www.uniprot.org/uniprotkb/Q5EA98" } ], "pmid": "" }, { "name": "microfibril", "id": "GO:0001527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001527", "evidence": [ { "database": "UniProtKB", "id": "Q5EA98", "url": "https://www.uniprot.org/uniprotkb/Q5EA98" } ], "pmid": "" }, { "name": "U2-type spliceosomal complex", "id": "GO:0005684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005684", "evidence": [ { "database": "UniProtKB", "id": "Q5EA98", "url": "https://www.uniprot.org/uniprotkb/Q5EA98" } ], "pmid": "" }, { "name": "U2-type precatalytic spliceosome", "id": "GO:0071005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071005", "evidence": [ { "database": "UniProtKB", "id": "Q5EA98", "url": "https://www.uniprot.org/uniprotkb/Q5EA98" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "Q5EA98", "url": "https://www.uniprot.org/uniprotkb/Q5EA98" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 309, "end_pos": 311, "annotation": "n_glycosylation_sequon" }, { "start_pos": 370, "end_pos": 372, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EA98-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 439, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EA98-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EA98" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 52, 53, 94, 116, 118, 132, 133, 267, 361, 432 ], "sequon_annotation_sites": [ { "start_pos": 309, "end_pos": 311 }, { "start_pos": 370, "end_pos": 372 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 10 }, { "field": "total_sites", "count": 10 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EAC2-1", "uniprot_ac": "Q5EAC2", "uniprot_id": "GSHB_BOVIN", "mass": { "chemical_mass": 52066.0, "monoisotopic_mass": 52066.0 }, "refseq": { "ac": "NP_001015630", "name": "glutathione synthetase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015630" }, "gene_names": [ { "name": "GSS", "type": "recommended", "evidence": [ { "id": "Q5EAC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC2" } ] }, { "name": "GSS", "type": "synonym", "evidence": [ { "id": "NP_001015630", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015630" } ] } ], "protein_names": [ { "name": "Glutathione synthetase", "type": "recommended", "evidence": [ { "id": "Q5EAC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC2/entry#names_and_taxonomy" } ] }, { "name": "6.3.2.3", "type": "synonym", "evidence": [ { "id": "Q5EAC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC2/entry#names_and_taxonomy" } ] }, { "name": "GSH synthetase", "type": "synonym", "evidence": [ { "id": "NP_001015630", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015630" }, { "id": "Q5EAC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC2/entry#names_and_taxonomy" } ] }, { "name": "GSH-S", "type": "synonym", "evidence": [ { "id": "NP_001015630", "database": 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Participates in ophthalmate biosynthesis in hepatocytes (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC2", "url": "https://www.uniprot.org/uniprotkb/Q5EAC2#function" }, { "database": "UniProtKB", "id": "P48637", "url": "https://www.uniprot.org/uniprotkb/P48637#function" }, { "database": "UniProtKB", "id": "P51855", "url": "https://www.uniprot.org/uniprotkb/P51855#function" } ] }, { "annotation": "PrP(c) is expressed in all digestive regions of the rat, monkey, and cow; PrP(c) expressing cells appeared scattered throughout the epithelium of fundic and pyloric glands as well as in intestinal villi and crypts.", "evidence": [ { "database": "RefSeq", "id": "NP_001015630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015630" }, { "database": "PubMed", "id": "15891070", "url": "https://glygen.org/publication/PubMed/15891070" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos 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"MATGWGSLLQDEQQLEELARQAVDRALAEGVLLRTSQAPSSSHVVSYAPFTLFPSPVPSALLEQAYAVQADFNLLVDAVSQNAVFLEQTLSSTIKRDSFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQCNPDGSAALKQIEINTVSASFGGLASRTPAVHRHVLSVLGKTKEAAKILSNNPSKGLAMGIAKAWELYGSANAQVLLIAQEKERNIFDQRAIENELLARNIHVIRRKFEDVSEKGSLDQDRRLFMDGQEIAVVYFRDGYMPGHYSLQNWEARLLLERSCAVKCPDIATQLAGTKKVQQELSRVGVLESFLPGQPEAVARLRATFAGLYSLDLGEEGDQAITKAIAAPSCFVLKPQREGGGNNLYGEEMVQALERLKDSEERASYILMEKIEPEPFRNCLLRPGSPARVIQCISELGIFGVYVREGKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYPV", "length": 474, "header": "sp|Q5EAC2-1|GSHB_BOVIN Isoform 1 of Glutathione synthetase OS=Bos taurus OX=9913 GN=GSS PE=2 SV=1 CANONICAL=Q5EAC2-1" }, "isoforms": [ { "isoform_ac": "Q5EAC2-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAC2/entry#Q5EAC2-1", "sequence": { "sequence": 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"enzyme" ], "publication": [ { "title": "Comparative study of PrPc expression in rat, monkey, and cow gastrointestinal tract.", "journal": "Annals of the New York Academy of Sciences", "date": "2005-04", "authors": "Marcos Z, Bodegas M E, Sesma M P, Guembe L", "evidence": [ { "database": "RefSeq", "id": "NP_001015630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015630" } ], "reference": [ { "type": "PubMed", "id": "15891070", "url": "https://glygen.org/publication/PubMed/15891070" } ] }, { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC2", "url": "https://www.uniprot.org/uniprotkb/Q5EAC2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:525059", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525059", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "glutathione synthase activity", "id": "GO:0004363", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004363", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC2", "url": "https://www.uniprot.org/uniprotkb/Q5EAC2" } ], "pmid": "" }, { "name": "glutathione binding", "id": "GO:0043295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043295", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC2", "url": "https://www.uniprot.org/uniprotkb/Q5EAC2" } ], "pmid": "" }, { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC2", "url": 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Inhibits HSP90AA1 ATPase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC6", "url": "https://www.uniprot.org/uniprotkb/Q5EAC6#function" }, { "database": "UniProtKB", "id": "Q16543", "url": "https://www.uniprot.org/uniprotkb/Q16543#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EAC6", "url": "https://www.uniprot.org/uniprotkb/Q5EAC6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDC37", "url": "https://www.uniprot.org/uniprotkb/Q5EAC6", "locus": { "chromosome": "7", "start_pos": 14926956, "end_pos": 14950522, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011699", "url": "https://www.ensembl.org/id/ENSBTAG00000011699" } ] } } ], "crossref": [ { "id": "Q5EAC6", "url": 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"Protein Classification", "Other" ] }, { "id": "PF08564", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08564", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08565", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08565", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1227986", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5675482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5675482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8863795", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8863795", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013418", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013418", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9652282", 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Hsp90 co-chaperone Cdc37 OS=Bos taurus OX=9913 GN=CDC37 PE=2 SV=1 CANONICAL=Q5EAC6-1" }, "isoforms": [ { "isoform_ac": "Q5EAC6-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAC6/entry#Q5EAC6-1", "sequence": { "sequence": "MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEQAEEESEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKDRVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDAKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKSSEAKDGEEAGTGDPLLEATSKSGDEKDVSV", "length": 380, "header": "sp|Q5EAC6-1|CDC37_BOVIN Isoform 1 of Hsp90 co-chaperone Cdc37 OS=Bos taurus OX=9913 GN=CDC37 PE=2 SV=1 CANONICAL=Q5EAC6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 120, "end_pos": 120, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": 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"Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC6", "url": "https://www.uniprot.org/uniprotkb/Q5EAC6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] }, { "title": "Direct interaction of the cell division cycle 37 homolog inhibits endothelial nitric oxide synthase activity.", "journal": "Circulation research", "date": "2006-02-17", "authors": "Harris M Brennan, Bartoli Manuela, Sood Sarika G, Matts Robert L, Venema Richard C", "evidence": [ { "database": "RefSeq", "id": "NP_001030415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030415" } ], "reference": [ { "type": "PubMed", "id": "16410463", "url": "https://glygen.org/publication/PubMed/16410463" } ] } ], "pathway": [ { "id": "bta:520883", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520883", "resource": "KEGG Pathway" }, { "id": "R-BTA-1227986", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1227986", "resource": "Reactome", "description": "Signaling by ERBB2" }, { "id": "R-BTA-5675482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5675482", "resource": "Reactome", "description": "Regulation of necroptotic cell death" }, { "id": "R-BTA-8863795", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8863795", "resource": "Reactome", "description": "Downregulation of ERBB2 signaling" }, { "id": "R-BTA-9013418", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013418", "resource": "Reactome", "description": "RHOBTB2 GTPase cycle" }, { "id": "R-BTA-9652282", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9652282", "resource": "Reactome", "description": "Drug-mediated inhibition of ERBB2 signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XA63-1", "protein_name": "Hsp90 co-chaperone Cdc37", "gene_name": "CDC37", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGVPILSLWWSPTSPYGDLHGGPHPFLRAAPVGIAISPELSPSLWGSPPPPQSCLHPYGGHHPLLRAVPIPVGVTTPSSELSPSLWGSPPPPQSCPHPILIVVPILSLWGSPWWSASPPQGCPHGGHHPLPRVAFQNRLWGPPFPPWGEGKGADPPPPFFPAQSSLLGVRAAPTACTGMGRLEGGGGDVCSLLPTPQSPKNMRQPPPPHTHTHFQARVERMEQFQKEKEELDKGCRECKRKLAECQKKLKELEVAEPGGGSGGVRGERERLQAEAQQLRHEERNWESKMEELRKKEKNMPWNVDTLSKDGFSKSVFNVKAEEKEETEEQKEQKHKTFVERHEKQIKHFGMLRRWDDSQKYLSDNPHLVCEETANYLVIWCIDLEVEEKQALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADQQYMEGFNDELEAFKERVRGRAKARIERAMREYEEEERQKRLGPGGLDPVDVYESLPPELQKCFDAKDVQMLQDTISRMDPTEAKYHMQRCIDSGLWVPNAKAAAEGGGQGGAHGQPGGADSEALYEEIPKESGEEEGGEGKA", "length": 574 }, "evidence": [ { "id": "Q5EAC6", "url": "https://omabrowser.org/oma/group/Q5EAC6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q16543-1", "protein_name": "Hsp90 co-chaperone Cdc37", "gene_name": "CDC37", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPGDPLLEAVPKTGDEKDVSV", "length": 378 }, "evidence": [ { "id": "Q5EAC6", "url": "https://omabrowser.org/oma/group/Q5EAC6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q24276-1", "protein_name": "Hsp90 co-chaperone Cdc37", "gene_name": "Cdc37", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVDYSKWKNIEISDDEDDTHPNIDTPSLFRWRHQARVERMAEMDHEKDELKKKRQSYQARLMDVKERISKKDGDEEALKKELEKIEAEGKELDRIESEMIKKEKKTPWNVDTISKPGFEKTVINKKAGRKPDENLSEEEREQRMKQFVKENEKLCQQYGMLRKYDDSKRFLQEHLHLVGEETANYLVIWSINLEMEEKHELMAHVAHQCICMQYILELAKQLDVDPRACVSSFFSKIQHCHPEYRAQFDSEIEGFKGRIQKRAQEKIQEAIAQAEEEERKERLGPGGLDPADVFESLPDELKACFESRDVELLQKTIAAMPVDVAKLHMKRCVDSGLWVPNAADLEGDKKEEDDSDDVAGGEEKTDDAKSESAAKEEPIYTGVSTEDVD", "length": 389 }, "evidence": [ { "id": "Q5EAC6", "url": "https://omabrowser.org/oma/group/Q5EAC6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q61081-1", "protein_name": "Hsp90 co-chaperone Cdc37", "gene_name": "Cdc37", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"header": "sp|Q5EAC9-1|HSPB8_BOVIN Isoform 1 of Heat shock protein beta-8 OS=Bos taurus OX=9913 GN=HSPB8 PE=2 SV=1 CANONICAL=Q5EAC9-1" }, "isoforms": [ { "isoform_ac": "Q5EAC9-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAC9/entry#Q5EAC9-1", "sequence": { "sequence": "MADGQMPFPCHYTSRRRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSAWPGTLRSGMVPRGPTAMTRFGVPAEGRSPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVEVSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSPFGESSFNNELPQDGQEVTCT", "length": 196, "header": "sp|Q5EAC9-1|HSPB8_BOVIN Isoform 1 of Heat shock protein beta-8 OS=Bos taurus OX=9913 GN=HSPB8 PE=2 SV=1 CANONICAL=Q5EAC9-1" }, "locus": { "chromosome": "17", "start_pos": 56169490, "end_pos": 56157558, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001720.3", "url": "https://www.ensembl.org/id/ENSBTAT00000001720.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001720.2", "url": "https://www.ensembl.org/id/ENSBTAP00000001720.2" } ] } } ], 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"MADGQLPFPCSYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTAPWPEWALPRLSSAWPGTLRSGMVPRGPTATARFGVPAEGRNPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVEVSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSPFGESSFNNELPQDNQEVTCS", "length": 196 }, "evidence": [ { "id": "Q5EAC9", "url": "https://omabrowser.org/oma/group/Q5EAC9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9JK92-1", "protein_name": "Heat shock protein beta-8", "gene_name": "Hspb8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADGQLPFPCSYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTAPWPEWALPRLSSAWPGTLRSGMVPRGPPATARFGVPAEGRSPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVEVSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPATVFASLSPEGLLIIEAPQVPPYSPFGESSFNNELPQDNQEVTCS", "length": 196 }, "evidence": [ { "id": "Q5EAC9", "url": "https://omabrowser.org/oma/group/Q5EAC9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UJY1-1", "protein_name": "Heat shock protein beta-8", "gene_name": "HSPB8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADGQMPFSCHYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSAWPGTLRSGMVPRGPTATARFGVPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVEVSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSTFGESSFNNELPQDSQEVTCT", "length": 196 }, "evidence": [ { "id": "Q5EAC9", "url": "https://omabrowser.org/oma/group/Q5EAC9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC9", "url": "https://www.uniprot.org/uniprotkb/Q5EAC9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC9", "url": "https://www.uniprot.org/uniprotkb/Q5EAC9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC9", "url": "https://www.uniprot.org/uniprotkb/Q5EAC9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC9", "url": "https://www.uniprot.org/uniprotkb/Q5EAC9" } ], "pmid": "" }, { "name": "protein folding chaperone complex", "id": "GO:0101031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0101031", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC9", "url": "https://www.uniprot.org/uniprotkb/Q5EAC9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC9", "url": "https://www.uniprot.org/uniprotkb/Q5EAC9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cellular response to unfolded protein", "id": "GO:0034620", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034620", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC9", "url": "https://www.uniprot.org/uniprotkb/Q5EAC9" } ], "pmid": "" }, { "name": "positive regulation of aggrephagy", "id": "GO:1905337", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905337", "evidence": [ { "database": "UniProtKB", "id": "Q5EAC9", "url": "https://www.uniprot.org/uniprotkb/Q5EAC9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EAC9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 196, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EAC9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EAC9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q5EAC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAC9" }, { "id": "PRU00285", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00285" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "sHSP", "eco_id": "ECO_0000255", "start_pos": 74, "end_pos": 185, "start_aa": "Thr", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 24, 57, 63, 87 ], "sequon_annotation_sites": [ { "start_pos": 138, "end_pos": 140 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EAD5-1", "uniprot_ac": "Q5EAD5", "uniprot_id": "PGTB1_BOVIN", "mass": { "chemical_mass": 42481.0, "monoisotopic_mass": 42481.0 }, "refseq": { "ac": "NP_001015560", "name": "geranylgeranyl transferase type-1 subunit beta", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015560" }, "gene_names": [ { "name": "PGGT1B", "type": "recommended", "evidence": [ { "id": "Q5EAD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5" } ] }, { "name": "PGGT1B", "type": "synonym", "evidence": [ { "id": "NP_001015560", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015560" } ] } ], "protein_names": [ { "name": "Geranylgeranyl transferase type-1 subunit beta", "type": "recommended", "evidence": [ { "id": "Q5EAD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5/entry#names_and_taxonomy" } ] }, { "name": "2.5.1.59", "type": "synonym", "evidence": [ { "id": "Q5EAD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5/entry#names_and_taxonomy" } ] }, { "name": "GGTase-I-beta", "type": "synonym", "evidence": [ { "id": "NP_001015560", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015560" }, { "id": "Q5EAD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5/entry#names_and_taxonomy" } ] }, { "name": "Geranylgeranyl transferase type I subunit beta", "type": "synonym", "evidence": [ { "id": "Q5EAD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5/entry#names_and_taxonomy" } ] }, { "name": "Type I protein geranyl-geranyltransferase subunit beta", "type": "synonym", "evidence": [ { "id": "Q5EAD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5/entry#names_and_taxonomy" } ] }, { "name": "geranylgeranyl transferase type I subunit beta", "type": "synonym", "evidence": [ { "id": "NP_001015560", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015560" } ] }, { "name": "geranylgeranyl transferase type-1 subunit beta", "type": "synonym", "evidence": [ { "id": "NP_001015560", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015560" } ] }, { "name": "protein geranylgeranyltransferase type I, beta subunit", "type": "synonym", "evidence": [ { "id": "NP_001015560", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015560" } ] }, { "name": "type I protein geranyl-geranyltransferase subunit beta", "type": "synonym", "evidence": [ { "id": "NP_001015560", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015560" } ] } ], "function": [ { "annotation": "Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5EAD5", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EAD5", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PGGT1B", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5", "locus": { "chromosome": "10", "start_pos": 4046135, "end_pos": 4104904, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001895", "url": "https://www.ensembl.org/id/ENSBTAG00000001895" } ] } } ], "crossref": [ { "id": "Q5EAD5", "url": "https://alphafold.ebi.ac.uk/entry/Q5EAD5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001895", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001895", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02895", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02895", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL2096987", "url": "https://www.ebi.ac.uk/chembl/target/inspect/CHEMBL2096987", "database": "ChEMBL", "categories": [ "Chemical" ] }, { "id": "509322", "url": "https://www.ncbi.nlm.nih.gov/gene/509322", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045089", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045089", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509322", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509322", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RWCLMRQ", "url": "https://omabrowser.org/oma/group/RWCLMRQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EAD5", "url": "https://www.orthodb.org/?gene=Q5EAD5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11774", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11774", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11774:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11774:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00432", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00432", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PR:Q5EAD5", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:Q5EAD5", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-BTA-9953170", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9953170", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015560", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "21240", "url": "https://www.rhea-db.org/rhea/21240", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5EAD5", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EAD5-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAATEDERPTGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAINYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKQCSENVHIST", "length": 377, "header": "sp|Q5EAD5-1|PGTB1_BOVIN Isoform 1 of Geranylgeranyl transferase type-1 subunit beta OS=Bos taurus OX=9913 GN=PGGT1B PE=2 SV=1 CANONICAL=Q5EAD5-1" }, "isoforms": [ { "isoform_ac": "Q5EAD5-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5/entry#Q5EAD5-1", "sequence": { "sequence": "MAATEDERPTGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAINYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKQCSENVHIST", "length": 377, "header": "sp|Q5EAD5-1|PGTB1_BOVIN Isoform 1 of Geranylgeranyl transferase type-1 subunit beta OS=Bos taurus OX=9913 GN=PGGT1B PE=2 SV=1 CANONICAL=Q5EAD5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EAD5", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:509322", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509322", "resource": "KEGG Pathway" }, { "id": "R-BTA-9953170", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9953170", "resource": "Reactome", "description": "GBP-mediated host defense" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2R1L1-1", "protein_name": "Geranylgeranyl transferase type-1 subunit beta", "gene_name": "PGGT1B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAATEDERPAGSGDGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKPCSENVHIST", "length": 377 }, "evidence": [ { "id": "Q5EAD5", "url": "https://omabrowser.org/oma/group/Q5EAD5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O80642-1", "protein_name": "Geranylgeranyl transferase type-1 subunit beta", "gene_name": "GGB", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSETAVSIDSDRSKSEEEDEEEYSPPVQSSPSANFEKDRHLMYLEMMYELLPYHYQSQEINRLTLAHFIISGLHFLGARDRVDKDVVAKWVLSFQAFPTNRVSLKDGEFYGFFGSRSSQFPIDENGDLKHNGSHLASTYCALAILKVIGHDLSTIDSKSLLISMINLQQDDGSFMPIHIGGETDLRFVYCAAAICYMLDSWSGMDKESAKNYILNCQSYDGGFGLIPGSESHGGATYCAIASLRLMGYIGVDLLSNDSSSSIIDPSLLLNWCLQRQANDGGFQGRTNKPSDTCYAFWIGAVLKLIGGDALIDKMALRKFLMSCQSKYGGFSKFPGQLPDLYHSYYGYTAFSLLEEQGLSPLCPELGLPLLAAPGI", "length": 375 }, "evidence": [ { "id": "Q5EAD5", "url": "https://omabrowser.org/oma/group/Q5EAD5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P53609-1", "protein_name": "Geranylgeranyl transferase type-1 subunit beta", "gene_name": "PGGT1B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST", "length": 377 }, "evidence": [ { "id": "Q5EAD5", "url": "https://omabrowser.org/oma/group/Q5EAD5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P53610-1", "protein_name": "Geranylgeranyl transferase type-1 subunit beta", "gene_name": "Pggt1b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAATEDDRLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKQCSDNVHISS", "length": 377 }, "evidence": [ { "id": "Q5EAD5", "url": "https://omabrowser.org/oma/group/Q5EAD5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q24173-1", "protein_name": "Geranylgeranyl transferase type-1 subunit beta", "gene_name": "betaggt-I", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEDRTDTEPVLLSKHAKNLLRFLNLLPARMASHDNTRSTIVFFAVCGLDVLNSLHLVPPQLRQDIIDWIYGGLVVPRDNEKNCGGFMGCRAMVPKTEDAEILECMRNYQWGHLAMTYTSLAVLVTLGDDLSRLDRKSIVDGVAAVQKPEGSFSACIDGSEDDMRFVYCAATICYMLDYWGDVNKETMFQFITRSLRYDYGFSQELEGEAHGGTTFCALAALHLSGQLHRLDATTVERMKRWLIFRQMDGFQGRPNKPVDTCYSFWIGASLCILDGFELTDYARNREFILSTQDKLIGGFAKWPQATPDPFHTYLGLCGLAFTGEPGLSPVNPSLNMSMAAYAHLQHLHEQWRSADGRGDEDISVSSAFKQQLHLSKGVEATSTTTTSNSPLISAQ", "length": 395 }, "evidence": [ { "id": "Q5EAD5", "url": "https://omabrowser.org/oma/group/Q5EAD5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q55DA3-1", "protein_name": "Geranylgeranyl transferase type-1 subunit beta", "gene_name": "pggt1b", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGSCINEEKLAKFFQRSLNALPAPYTSGLPNHLSLIFFVVSGLDLLNKTDILEKEKQDIINWVYSRQILPSKDNPEINLENCGFRGYNFLGQEFCCDKSVHTSENGPLEYDLPSTPNTYCALLILRILGDDFSGVNKKAIIDSLRKRQRESDGAISGSPNVGDYDLRHLFSACAISFILDDWSAINKESAIDYIKSCLSYEFAFGQTPQQEAHGGPTYCAIASLSLLGRLDVLEPFKEQLTFWLVKKQITGFCGRTNKDPDTCYAFWIGASLMMIDRYDLIDFASINAFIGSAQHEAIGGVAKEPGQLPDVMHSYLSLVGLSFGNIPSIQQVIPCLNLSKRAAGKDWFEKLI", "length": 352 }, "evidence": [ { "id": "Q5EAD5", "url": "https://omabrowser.org/oma/group/Q5EAD5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8BUY9-1", "protein_name": "Geranylgeranyl transferase type-1 subunit beta", "gene_name": "Pggt1b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATTEDDRLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLSRCGFRGSSYLGIPFNPSKNPGAAHPYDSGHIAMTYTGLSCLIILGDDLGRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKQCSDNVHIAT", "length": 377 }, "evidence": [ { "id": "Q5EAD5", "url": "https://omabrowser.org/oma/group/Q5EAD5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein geranylgeranyltransferase activity", "id": "GO:0004661", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004661", "evidence": [ { "database": "UniProtKB", "id": "Q5EAD5", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5" } ], "pmid": "" }, { "name": "CAAX-protein geranylgeranyltransferase activity", "id": "GO:0004662", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004662", "evidence": [ { "database": "UniProtKB", "id": "Q5EAD5", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q5EAD5", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "CAAX-protein geranylgeranyltransferase complex", "id": "GO:0005953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005953", "evidence": [ { "database": "UniProtKB", "id": "Q5EAD5", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein geranylgeranylation", "id": "GO:0018344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018344", "evidence": [ { "database": "UniProtKB", "id": "Q5EAD5", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 345, "end_pos": 347, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21240", "name": "", "equation": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5EA80-1", "A0AAF6Z5M1-1", "Q5EAD5-1", "P29702-1", "Q5E9B3-1", "A0AAA9SWU6-1", "A0AAA9S4G1-1" ], "evidence": [ { "id": "21240", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21240" } ] }, { "id": "R-BTA-9947999", "name": "FNTA:PGGT1B geranylgeranylates GBP2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-BTA-1015673" ], "output_participant_list": [ "R-BTA-9947851" ], "enzyme_list": [ "A0AAA9S4G1-1", "Q5EAD5-1" ], "evidence": [ { "id": "R-BTA-9947999", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9947999" } ] }, { "id": "R-BTA-9954195", "name": "FNTA:PGGT1B geranylgeranylates GBP5", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-9947981", "R-BTA-1031692" ], "output_participant_list": [ "R-BTA-9954196" ], "enzyme_list": [ "A0AAA9S4G1-1", "Q5EAD5-1" ], "evidence": [ { "id": "R-BTA-9954195", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954195" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-9947981", "participant_name": "GGPP [cytosol]", "crossref": [ { "id": "57533", "database": "ChEBI", "url": "" }, { "id": "ZINC000012495043", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-BTA-1015673", "participant_name": "LOC132342100 [cytosol]", "crossref": [ { "id": "F1MDI9", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000037634", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000050757", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000056911", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-1031692", "participant_name": "GBP5 [cytosol]", "crossref": [ { "id": "Q0IID3", "database": "UniProt", "url": "" }, { "id": "XP_015319877.1", "database": "RefSeq", "url": "" }, { "id": "NP_001069214.1", "database": "RefSeq", "url": "" }, { "id": "59183", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-9947851", "participant_name": "LOC132342100 [cytosol]", "crossref": [ { "id": "F1MDI9", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000050757", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000056911", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000037634", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-9954196", "participant_name": "GBP5 [cytosol]", "crossref": [ { "id": "XP_015319877.1", "database": "RefSeq", "url": "" }, { "id": "59183", "database": "VGNC", "url": "" }, { "id": "NP_001069214.1", "database": "RefSeq", "url": "" }, { "id": "Q0IID3", "database": "UniProt", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9S4G1", "gene_name": "FNTA", "activity": [ { "ec_number": "2.5.1.58", "activity": "L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] }, { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] }, { "ec_number": "2.5.1.58", "activity": "", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] } ] }, { "uniprot_ac": "A0AAA9SWU6", "gene_name": "PGGT1B", "activity": [ { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAA9SWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "A0AAA9SWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6" } ] } ] }, { "uniprot_ac": "A0AAF6Z5M1", "gene_name": "RABGGTB", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAF6Z5M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "A0AAF6Z5M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1" } ] } ] }, { "uniprot_ac": "P29702", "gene_name": "FNTA", "activity": [ { "ec_number": "2.5.1.58", "activity": "L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "P29702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29702" } ] }, { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "P29702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29702" } ] }, { "ec_number": "2.5.1.58", "activity": "", "evidence": [ { "id": "P29702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29702" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "P29702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29702" } ] } ] }, { "uniprot_ac": "Q5E9B3", "gene_name": "RABGGTB", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ] } ] }, { "uniprot_ac": "Q5EA80", "gene_name": "RABGGTA", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ] } ] }, { "uniprot_ac": "Q5EAD5", "gene_name": "PGGT1B", "activity": [ { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "Q5EAD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "Q5EAD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EAD5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 377, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EAD5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EAD5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "Q5EAD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5#function" }, { "id": "Q5EAD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5" } ], "binding_site_uniprot": 269, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000250", "start_pos": 269, "end_pos": 269, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5EAD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5#function" }, { "id": "Q5EAD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5" } ], "binding_site_uniprot": 271, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000250", "start_pos": 271, "end_pos": 271, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q5EAD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5#function" }, { "id": "Q5EAD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5" } ], "binding_site_uniprot": 321, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000250", "start_pos": 321, "end_pos": 321, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.5.1.59", "ec_name": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "2.5.1.59", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59" }, { "id": "2.5.1.59", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.5.1.59" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 187, "end_pos": 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[] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.", "evidence": [ { "database": "UniProtKB", "id": "Q5EAD6", "url": "https://www.uniprot.org/uniprotkb/Q5EAD6#function" }, { "database": "UniProtKB", "id": "P61313", "url": "https://www.uniprot.org/uniprotkb/P61313#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EAD6", "url": "https://www.uniprot.org/uniprotkb/Q5EAD6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPL15", "url": "https://www.uniprot.org/uniprotkb/Q5EAD6", "locus": { "chromosome": "27", "start_pos": 42051425, "end_pos": 42055369, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033080", "url": "https://www.ensembl.org/id/ENSBTAG00000033080" } ] } } ], "crossref": [ { "id": "Q5EAD6", "url": "https://alphafold.ebi.ac.uk/entry/Q5EAD6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033080", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033080", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507151", "url": "https://www.ncbi.nlm.nih.gov/gene/507151", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012678", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012678", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020925", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020925", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024794", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024794", "database": "InterPro", "categories": [ "Protein 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"https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001071334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071334", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EAD6", "url": "https://www.uniprot.org/uniprotkb/Q5EAD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EAD6-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAD6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRLGYKAKQGYVIYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSVAEERAGRHCGALRVLNSYWVGEDSTYKFFEVILIDPFHKAIRRNPDTQWITKPVHKHREMRGLTSAGRKSRGLGKGHKFHHTIGGSRRAAWRRRNTLQLHRYR", "length": 204, "header": "sp|Q5EAD6-1|RL15_BOVIN Isoform 1 of Large ribosomal subunit protein eL15 OS=Bos taurus OX=9913 GN=RPL15 PE=2 SV=3 CANONICAL=Q5EAD6-1" }, "isoforms": [ { "isoform_ac": "Q5EAD6-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAD6/entry#Q5EAD6-1", "sequence": { "sequence": "MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRLGYKAKQGYVIYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSVAEERAGRHCGALRVLNSYWVGEDSTYKFFEVILIDPFHKAIRRNPDTQWITKPVHKHREMRGLTSAGRKSRGLGKGHKFHHTIGGSRRAAWRRRNTLQLHRYR", "length": 204, "header": "sp|Q5EAD6-1|RL15_BOVIN Isoform 1 of Large ribosomal subunit protein eL15 OS=Bos taurus OX=9913 GN=RPL15 PE=2 SV=3 CANONICAL=Q5EAD6-1" }, "locus": { "chromosome": "27", "start_pos": 42054918, "end_pos": 42052968, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020729.5", "url": "https://www.ensembl.org/id/ENSBTAT00000020729.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044213.2", "url": "https://www.ensembl.org/id/ENSBTAP00000044213.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 100, "end_pos": 100, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EAD6", "url": "https://www.uniprot.org/uniprotkb/Q5EAD6" } ], "site_lbl": "Ser100" }, { "start_pos": 34, "end_pos": 34, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EAD6", "url": "https://www.uniprot.org/uniprotkb/Q5EAD6" } ], "site_lbl": "Ser34" }, { "start_pos": 97, "end_pos": 97, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EAD6", "url": "https://www.uniprot.org/uniprotkb/Q5EAD6" } ], "site_lbl": "Ser97" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EAD6", "url": "https://www.uniprot.org/uniprotkb/Q5EAD6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:507151", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507151", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "F1NQG5-1", "protein_name": "Ribosomal protein L15", "gene_name": "RPL15", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRLGYKAKQGYVIYRVRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSVAEERAGRHCGALRVLNSYWVGEDSTYKFFEVILIDPFHKAIRRNPDTQWITKPVHKHREMRGLTSAGRKSRGLGKGHKFHHTIGGSRRAAWRRRNTLQLHRYR", "length": 204 }, "evidence": [ { "id": "Q5EAD6", "url": "https://omabrowser.org/oma/group/Q5EAD6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3H1F4-1", "protein_name": "Ribosomal protein L15", "gene_name": "Rpl15", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRLGYKAKQGYVIYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSVAEERAGRHCGALRVLNSYWVGEDSTYKFFEVILIDPFHKAIRRNPDTQWITKPVHKHREMRGLTSAGRKSRGLGKGHKFHHTIGGSRRAAWRRRNTLQLHRYR", "length": 204 }, "evidence": [ { "id": "Q5EAD6", "url": "https://omabrowser.org/oma/group/Q5EAD6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O17445-1", "protein_name": "Large ribosomal subunit protein eL15", "gene_name": "RpL15", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGAYRYMQELYRKKQSDVMRYLLRIRVWQYRQLTKLHRSPRPTRPDKARRLGYRAKQGFVIYRIRVRRGGRKRPVPKGCTYGKPKSHGVNQLKPYRGLQSIAEERVGRRLGGLRVLNSYWIAQDASYKYFEVILIDTHHSAIRRDPKINWICKHVHKHRELRGLTSAGKSSRGIGKGYRYSQTIGGSRRAAWKRKNREHMHRKR", "length": 204 }, "evidence": [ { "id": "Q5EAD6", "url": "https://omabrowser.org/oma/group/Q5EAD6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "O23515-1", "protein_name": "Large ribosomal subunit protein eL15z", "gene_name": "RPL15A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGAYKYVSELWRKKQSDVMRFLQRVRCWEYRQQPSIVRLVRPTRPDKARRLGYKAKQGFVVYRVRVRRGGRKRPVPKGIVYGKPTNQGVTQLKFQRSKRSVAEERAGRKLGGLRVVNSYWLNEDSTYKYYEIILVDPAHNAVRNDPRINWICNPVHKHRELRGLTSEGKKNRGLRGKGHNNHKNRPSRRATWKKNNSLSLRRYR", "length": 204 }, "evidence": [ { "id": "Q5EAD6", "url": "https://omabrowser.org/oma/group/Q5EAD6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P05748-1", "protein_name": "Large ribosomal subunit protein eL15A", "gene_name": "RPL15A", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MGAYKYLEELQRKKQSDVLRFLQRVRVWEYRQKNVIHRAARPTRPDKARRLGYKAKQGFVIYRVRVRRGNRKRPVPKGATYGKPTNQGVNELKYQRSLRATAEERVGRRAANLRVLNSYWVNQDSTYKYFEVILVDPQHKAIRRDARYNWICDPVHKHREARGLTATGKKSRGINKGHKFNNTKAGRRKTWKRQNTLSLWRYRK", "length": 204 }, "evidence": [ { "id": "Q5EAD6", "url": "https://omabrowser.org/oma/group/Q5EAD6/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P61313-1", "protein_name": "Large ribosomal subunit protein eL15", "gene_name": "RPL15", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRLGYKAKQGYVIYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSVAEERAGRHCGALRVLNSYWVGEDSTYKFFEVILIDPFHKAIRRNPDTQWITKPVHKHREMRGLTSAGRKSRGLGKGHKFHHTIGGSRRAAWRRRNTLQLHRYR", "length": 204 }, "evidence": [ { "id": "Q5EAD6", "url": "https://omabrowser.org/oma/group/Q5EAD6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P61314-1", "protein_name": "Large ribosomal subunit protein eL15", "gene_name": "Rpl15", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRLGYKAKQGYVIYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSVAEERAGRHCGALRVLNSYWVGEDSTYKFFEVILIDPFHKAIRRNPDTQWITKPVHKHREMRGLTSAGRKSRGLGKGHKFHHTIGGSRRAAWRRRNTLQLHRYR", "length": 204 }, "evidence": [ { "id": "Q5EAD6", "url": "https://omabrowser.org/oma/group/Q5EAD6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86K01-1", "protein_name": "Large ribosomal subunit protein eL15", "gene_name": "rpl15-2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGAYKYLQELYKKKQSDAVRFLLRVRCWEYRNLPVCHRASHPTRVDKARRLGYKATQGFVVYRIRVRRGGRKRQVPGGRTGGKPKTHGVNELKPSRNLRSVAEERVGRRCPNLRVLNSYWVNQDSTYKYYEVILVDNSHNAIRNDPRYNWICKPVHKHRELRGLTSAGIKARGLRRKGTHRASKTRPSRQANYKRRNTVVFHRYR", "length": 205 }, "evidence": [ { "id": "Q5EAD6", "url": "https://omabrowser.org/oma/group/Q5EAD6/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9CZM2-1", "protein_name": "Large ribosomal subunit protein eL15", "gene_name": "Rpl15", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRLGYKAKQGYVIYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSVAEERAGRHCGALRVLNSYWVGEDSTYKFFEVILIDPFHKAIRRNPDTQWITKPVHKHREMRGLTSAGRKSRGLGKGHKFHHTIGGSRRAAWRRRNTLQLHRYR", "length": 204 }, "evidence": [ { "id": "Q5EAD6", "url": "https://omabrowser.org/oma/group/Q5EAD6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q5EAD6", "url": "https://www.uniprot.org/uniprotkb/Q5EAD6" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q5EAD6", "url": "https://www.uniprot.org/uniprotkb/Q5EAD6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "Q5EAD6", "url": "https://www.uniprot.org/uniprotkb/Q5EAD6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "Q5EAD6", "url": "https://www.uniprot.org/uniprotkb/Q5EAD6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q5EAD6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 204, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q5EAD6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q5EAD6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 34, 97, 100 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EAE2-1", "uniprot_ac": "Q5EAE2", "uniprot_id": "TADA3_BOVIN", "mass": { "chemical_mass": 48902.0, "monoisotopic_mass": 48902.0 }, "refseq": { "ac": "NP_001019682", "name": "transcriptional adapter 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019682" }, "gene_names": [ { "name": "TADA3", "type": "recommended", "evidence": [ { "id": "Q5EAE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2" } ] }, { "name": "ADA3", "type": "synonym", "evidence": [ { "id": "Q5EAE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2" } ] }, { "name": "TADA3L", "type": "synonym", "evidence": [ { "id": "NP_001019682", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019682" }, { "id": "Q5EAE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2" } ] }, { "name": "TADA3", "type": "synonym", "evidence": [ { "id": "NP_001019682", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019682" } ] } ], "protein_names": [ { "name": "Transcriptional adapter 3", "type": "recommended", "evidence": [ { "id": "Q5EAE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2/entry#names_and_taxonomy" } ] }, { "name": "ADA3 homolog", "type": "synonym", "evidence": [ { "id": "NP_001019682", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019682" }, { "id": "Q5EAE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2/entry#names_and_taxonomy" } ] }, { "name": "ADA3-like protein", "type": "synonym", "evidence": [ { "id": "NP_001019682", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019682" }, { "id": "Q5EAE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2/entry#names_and_taxonomy" } ] }, { "name": "Transcriptional adapter 3-like", "type": "synonym", "evidence": [ { "id": "Q5EAE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2/entry#names_and_taxonomy" } ] }, { "name": "transcriptional adapter 3", "type": "synonym", "evidence": [ { "id": "NP_001019682", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019682" } ] } ], "function": [ { "annotation": "Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE2", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EAE2", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TADA3", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2", "locus": { "chromosome": "22", "start_pos": 16933837, "end_pos": 16922281, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007961", "url": "https://www.ensembl.org/id/ENSBTAG00000007961" } ] } } ], "crossref": [ { "id": "Q5EAE2", "url": "https://alphafold.ebi.ac.uk/entry/Q5EAE2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007961", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007961", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510184", "url": "https://www.ncbi.nlm.nih.gov/gene/510184", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510184", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510184", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TPNKFWA", "url": "https://omabrowser.org/oma/group/TPNKFWA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q5EAE2", "url": "https://www.orthodb.org/?gene=Q5EAE2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13556", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13556", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13556:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13556:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10198", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10198", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689880", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9772755", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9772755", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001019682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019682", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EAE2", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EAE2-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKAGHGPGPGPGRPKSKNLQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLLDG", "length": 432, "header": "sp|Q5EAE2-1|TADA3_BOVIN Isoform 1 of Transcriptional adapter 3 OS=Bos taurus OX=9913 GN=TADA3 PE=2 SV=1 CANONICAL=Q5EAE2-1" }, "isoforms": [ { "isoform_ac": "Q5EAE2-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2/entry#Q5EAE2-1", "sequence": { "sequence": "MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKAGHGPGPGPGRPKSKNLQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLLDG", "length": 432, "header": "sp|Q5EAE2-1|TADA3_BOVIN Isoform 1 of Transcriptional adapter 3 OS=Bos taurus OX=9913 GN=TADA3 PE=2 SV=1 CANONICAL=Q5EAE2-1" }, "locus": { "chromosome": "22", "start_pos": 16933482, "end_pos": 16924828, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047754.6", "url": "https://www.ensembl.org/id/ENSBTAT00000047754.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044929.3", "url": "https://www.ensembl.org/id/ENSBTAP00000044929.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 280, "end_pos": 280, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE2", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2" } ], "site_lbl": "Ser280" }, { "start_pos": 298, "end_pos": 298, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE2", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2" } ], "site_lbl": "Ser298" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE2", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:510184", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510184", "resource": "KEGG Pathway" }, { "id": "R-BTA-5689880", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689880", "resource": "Reactome", "description": "Ub-specific processing proteases" }, { "id": "R-BTA-9772755", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9772755", "resource": "Reactome", "description": "Formation of WDR5-containing histone-modifying complexes" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MBA4-1", "protein_name": "Transcriptional adapter 3", "gene_name": "Tada3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKAGHGPGPGPGRPKSKNVQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLLDG", "length": 432 }, "evidence": [ { "id": "Q5EAE2", "url": "https://omabrowser.org/oma/group/Q5EAE2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1SQF7-1", "protein_name": "Transcriptional adapter 3", "gene_name": "TADA3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKAGHGPGPGPGRPKSKNLQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAMADKKKGLMGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLLDG", "length": 432 }, "evidence": [ { "id": "Q5EAE2", "url": "https://omabrowser.org/oma/group/Q5EAE2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O75528-1", "protein_name": "Transcriptional adapter 3", "gene_name": "TADA3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKAGHGPGPGPGRPKSKNLQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLLDG", "length": 432 }, "evidence": [ { "id": "Q5EAE2", "url": "https://omabrowser.org/oma/group/Q5EAE2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q4V8F5-1", "protein_name": "Transcriptional adapter 3", "gene_name": "Tada3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSELKDCPLQFHDFKSVDHMKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRRILKLARDHELGAPPKHGKPKKQKLEGKTGHGPGPGPGRPKSKNVQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLIGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLLDG", "length": 432 }, "evidence": [ { "id": "Q5EAE2", "url": "https://omabrowser.org/oma/group/Q5EAE2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R0L9-1", "protein_name": "Transcriptional adapter 3", "gene_name": "Tada3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKTGHGPGPGPGRPKSKNVQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLIGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLLDG", "length": 432 }, "evidence": [ { "id": "Q5EAE2", "url": "https://omabrowser.org/oma/group/Q5EAE2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "transcription factor TFTC complex", "id": "GO:0033276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033276", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE2", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2" } ], "pmid": "" }, { "name": "SAGA complex", "id": "GO:0000124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000124", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE2", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2" } ], "pmid": "" }, { "name": "mitotic spindle", "id": "GO:0072686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE2", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2" } ], "pmid": "" }, { "name": "ATAC complex", "id": "GO:0140672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140672", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE2", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE2", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE2", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE2", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE2", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE2", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2" } ], "pmid": "" }, { "name": "regulation of embryonic development", "id": "GO:0045995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045995", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE2", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2" } ], "pmid": "" }, { "name": "regulation of cell division", "id": "GO:0051302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051302", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE2", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE2", "url": "https://www.uniprot.org/uniprotkb/Q5EAE2" } ], "pmid": "" }, { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE2", "url": 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"cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 280, 298 ], "sequon_annotation_sites": [ { "start_pos": 360, "end_pos": 362 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q5EAE5-1", "uniprot_ac": "Q5EAE5", "uniprot_id": "JOS1_BOVIN", "mass": { "chemical_mass": 23181.0, "monoisotopic_mass": 23181.0 }, "refseq": { "ac": "NP_001014898", "name": "josephin-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014898" }, "gene_names": [ { "name": "JOSD1", "type": "recommended", "evidence": [ { "id": "Q5EAE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAE5" } ] }, { "name": "JOSD1", "type": "synonym", "evidence": [ { "id": "NP_001014898", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014898" } ] } ], "protein_names": [ { "name": "Josephin-1", "type": "recommended", "evidence": [ { "id": "Q5EAE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAE5/entry#names_and_taxonomy" } ] }, { "name": "3.4.19.12", "type": "synonym", "evidence": [ { "id": "Q5EAE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAE5/entry#names_and_taxonomy" } ] }, { "name": "Josephin domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "Q5EAE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAE5/entry#names_and_taxonomy" } ] }, { "name": "josephin domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001014898", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014898" } ] }, { "name": "josephin-1", "type": "synonym", "evidence": [ { "id": "NP_001014898", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014898" } ] } ], "function": [ { "annotation": "Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE5", "url": "https://www.uniprot.org/uniprotkb/Q5EAE5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EAE5", "url": "https://www.uniprot.org/uniprotkb/Q5EAE5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "JOSD1", "url": "https://www.uniprot.org/uniprotkb/Q5EAE5", "locus": { "chromosome": "5", "start_pos": 110317485, "end_pos": 110328176, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065598", "url": "https://www.ensembl.org/id/ENSBTAG00000065598" } ] } } ], "crossref": [ { "id": "Q5EAE5", "url": "https://alphafold.ebi.ac.uk/entry/Q5EAE5", "database": "AlphaFoldDB", "categories": [] }, { "id": "510781", "url": "https://www.ncbi.nlm.nih.gov/gene/510781", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006155", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006155", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040053", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040053", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510781", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510781", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q5EAE5", "url": "https://www.orthodb.org/?gene=Q5EAE5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13291", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13291", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13291:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13291:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02099", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02099", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014898", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014898", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q5EAE5", "url": "https://www.uniprot.org/uniprotkb/Q5EAE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5EAE5-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAE5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSCVPWKGDKVKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRETLQEIFQRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGAIALTNVMGFIMNLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGKSELRKFLKHHLRGKNCELLLVVPEEVEAHQSWRADV", "length": 202, "header": "sp|Q5EAE5-1|JOS1_BOVIN Isoform 1 of Josephin-1 OS=Bos taurus OX=9913 GN=JOSD1 PE=2 SV=1 CANONICAL=Q5EAE5-1" }, "isoforms": [ { "isoform_ac": "Q5EAE5-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAE5/entry#Q5EAE5-1", "sequence": { "sequence": "MSCVPWKGDKVKSESLELPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRETLQEIFQRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGAIALTNVMGFIMNLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGKSELRKFLKHHLRGKNCELLLVVPEEVEAHQSWRADV", "length": 202, "header": "sp|Q5EAE5-1|JOS1_BOVIN Isoform 1 of Josephin-1 OS=Bos taurus OX=9913 GN=JOSD1 PE=2 SV=1 CANONICAL=Q5EAE5-1" }, "locus": { "chromosome": "5", "start_pos": 110327567, "end_pos": 110319485, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123637.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123637.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095965.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095965.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 15, "end_pos": 15, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE5", "url": "https://www.uniprot.org/uniprotkb/Q5EAE5" } ], "site_lbl": "Ser15" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE5", "url": "https://www.uniprot.org/uniprotkb/Q5EAE5" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:510781", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510781", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { 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Involved in mediating interferon-gamma-induced cell death (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE6", "url": "https://www.uniprot.org/uniprotkb/Q5EAE6#function" }, { "database": "UniProtKB", "id": "Q9I9N1", "url": "https://www.uniprot.org/uniprotkb/Q9I9N1#function" }, { "database": "UniProtKB", "id": "P51397", "url": "https://www.uniprot.org/uniprotkb/P51397#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5EAE6", "url": "https://www.uniprot.org/uniprotkb/Q5EAE6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DAP", "url": "https://www.uniprot.org/uniprotkb/Q5EAE6", "locus": { "chromosome": "20", "start_pos": 62580669, "end_pos": 62513847, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": 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"sequence": { "sequence": "MSSPPEGKLETKAGHPPAVKAGGMRIVQKHPHSGDTREEKDKDDQEWESPSPPKPTVFISGVIARGDKDFPPAAAQVAHQKPHASIDRHPSPRTQHIQQPRK", "length": 102, "header": "sp|Q5EAE6-1|DAP1_BOVIN Isoform 1 of Death-associated protein 1 OS=Bos taurus OX=9913 GN=DAP PE=3 SV=3 CANONICAL=Q5EAE6-1" }, "isoforms": [ { "isoform_ac": "Q5EAE6-1", "url": "https://www.uniprot.org/uniprotkb/Q5EAE6/entry#Q5EAE6-1", "sequence": { "sequence": "MSSPPEGKLETKAGHPPAVKAGGMRIVQKHPHSGDTREEKDKDDQEWESPSPPKPTVFISGVIARGDKDFPPAAAQVAHQKPHASIDRHPSPRTQHIQQPRK", "length": 102, "header": "sp|Q5EAE6-1|DAP1_BOVIN Isoform 1 of Death-associated protein 1 OS=Bos taurus OX=9913 GN=DAP PE=3 SV=3 CANONICAL=Q5EAE6-1" }, "locus": { "chromosome": "20", "start_pos": 62578909, "end_pos": 62513955, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008327.5", "url": "https://www.ensembl.org/id/ENSBTAT00000008327.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008327.2", "url": 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"kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE6", "url": "https://www.uniprot.org/uniprotkb/Q5EAE6" } ], "site_lbl": "Ser91" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE6", "url": "https://www.uniprot.org/uniprotkb/Q5EAE6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:616066", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616066", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": 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"organism": "Mus musculus", "sequence": { "sequence": "MSSPPEGKLETKAGHPPAVKAGGMRIVQKHPHTGDGKEERDKDDQEWESTSPPKPTVFISGVIARGDKDFPPAAAQVAHQKPHASMDKHVSPRTQHIQQPRK", "length": 102 }, "evidence": [ { "id": "Q5EAE6", "url": "https://omabrowser.org/oma/group/Q5EAE6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "apoptotic signaling pathway", "id": "GO:0097190", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097190", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE6", "url": "https://www.uniprot.org/uniprotkb/Q5EAE6" } ], "pmid": "" }, { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "Q5EAE6", "url": "https://www.uniprot.org/uniprotkb/Q5EAE6" } ], "pmid": "" }, { "name": "negative regulation of autophagy", "id": "GO:0010507", "url": 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"type": "synonym", "evidence": [ { "id": "Q5G235", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5G235/entry#names_and_taxonomy" } ] }, { "name": "gamma-secretase subunit PEN-2", "type": "synonym", "evidence": [ { "id": "NP_001008669", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008669" } ] }, { "name": "presenilin enhancer 2 homolog", "type": "synonym", "evidence": [ { "id": "NP_001008669", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008669" } ] }, { "name": "presenilin enhancer protein 2", "type": "synonym", "evidence": [ { "id": "NP_001008669", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008669" } ] } ], "function": [ { "annotation": "Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (By similarity). Besides its role in gamma-secretase complex, acts as a regulator of AMP-activated protein kinase (AMPK) activity in response to calorie restriction: binds metformin, an antidiabetic drug, promoting association with ATP6AP1, a subunit of the V-ATPase complex, leading to V-ATPase complex inhibition on lysosomes and AMPK activation via the AXIN1-STK11/LKB1 axis (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q5G235", "url": "https://www.uniprot.org/uniprotkb/Q5G235#function" }, { "database": "UniProtKB", "id": "Q9NZ42", "url": "https://www.uniprot.org/uniprotkb/Q9NZ42#function" }, { "database": "UniProtKB", "id": "Q9CQR7", "url": "https://www.uniprot.org/uniprotkb/Q9CQR7#function" } ] }, { "annotation": "The PSENEN gene is down-regulated in bovine intramuscular fibroblast cells during differentiation into adipocytes. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_001008669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008669" }, { "database": "PubMed", "id": "19592191", "url": "https://glygen.org/publication/PubMed/19592191" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5G235", "url": "https://www.uniprot.org/uniprotkb/Q5G235" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PSENEN", "url": "https://www.uniprot.org/uniprotkb/Q5G235", "locus": { "chromosome": "18", "start_pos": 46460717, "end_pos": 46458839, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018593", "url": "https://www.ensembl.org/id/ENSBTAG00000018593" } ] } } ], "crossref": [ { "id": "Q5G235", "url": "https://alphafold.ebi.ac.uk/entry/Q5G235", 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"url": "https://www.uniprot.org/uniprotkb/Q5I598", "locus": { "chromosome": "16", "start_pos": 41887672, "end_pos": 41872982, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020698", "url": "https://www.ensembl.org/id/ENSBTAG00000020698" } ] } } ], "crossref": [ { "id": "Q5I598", "url": "https://alphafold.ebi.ac.uk/entry/Q5I598", "database": "AlphaFoldDB", "categories": [] }, { "id": "1.5.1.20", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.5.1.20&UniProtAcc=Q5I598", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd00537", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00537", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "497032", "url": "https://www.ncbi.nlm.nih.gov/gene/497032", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003171", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003171", "database": "InterPro", "categories": [ "Protein 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"https://www.uniprot.org/uniprotkb/Q5I598" } ], "site_lbl": "Ser22" }, { "start_pos": 24, "end_pos": 24, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5I598", "url": "https://www.uniprot.org/uniprotkb/Q5I598" } ], "site_lbl": "Ser24" }, { "start_pos": 25, "end_pos": 25, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5I598", "url": "https://www.uniprot.org/uniprotkb/Q5I598" } ], "site_lbl": "Ser25" }, { "start_pos": 28, "end_pos": 28, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5I598", "url": "https://www.uniprot.org/uniprotkb/Q5I598" } ], "site_lbl": "Ser28" }, { "start_pos": 29, "end_pos": 29, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5I598", "url": "https://www.uniprot.org/uniprotkb/Q5I598" } ], "site_lbl": "Ser29" }, { "start_pos": 33, "end_pos": 33, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5I598", "url": "https://www.uniprot.org/uniprotkb/Q5I598" } ], "site_lbl": "Thr33" }, { "start_pos": 393, "end_pos": 393, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5I598", "url": "https://www.uniprot.org/uniprotkb/Q5I598" } ], "site_lbl": "Ser393" }, { "start_pos": 450, "end_pos": 450, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5I598", "url": "https://www.uniprot.org/uniprotkb/Q5I598" } ], "site_lbl": "Thr450" }, { "start_pos": 93, "end_pos": 93, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5I598", "url": "https://www.uniprot.org/uniprotkb/Q5I598" } ], "site_lbl": "Thr93" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Embryonic MTHFR contributes to blastocyst development.", "journal": "Journal of assisted reproduction and genetics", "date": "2020-08", "authors": "Ishitani Hiroki, Ikeda Shuntaro, Egashira Kai, Sugimoto Miki, Kume Shinichi, Minami Naojiro, Ohta Takeshi", "evidence": [ { "database": "RefSeq", "id": "NP_001011685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011685" } ], "reference": [ { "type": "PubMed", "id": "32767205", "url": "https://glygen.org/publication/PubMed/32767205" } ] } ], "pathway": [ { "id": "bta:497032", "name": "", "url": 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[ "Protein" ] }, { "id": "Q5KR47-1", "url": "https://www.uniprot.org/uniprotkb/Q5KR47-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5KR47-2", "url": "https://www.uniprot.org/uniprotkb/Q5KR47-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAISEELDHALNDMTSI", "length": 284, "header": "sp|Q5KR47-1|TPM3_BOVIN Isoform 1 of Tropomyosin alpha-3 chain OS=Bos taurus OX=9913 GN=TPM3 PE=2 SV=1 CANONICAL=Q5KR47-1" }, "isoforms": [ { "isoform_ac": "Q5KR47-1", "url": "https://www.uniprot.org/uniprotkb/Q5KR47/entry#Q5KR47-1", "sequence": { "sequence": 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The non-muscle isoform may have a role in agonist-mediated receptor internalization.", "evidence": [ { "database": "UniProtKB", "id": "Q5KR48", "url": "https://www.uniprot.org/uniprotkb/Q5KR48#function" }, { "database": "UniProtKB", "id": "P58775", "url": "https://www.uniprot.org/uniprotkb/P58775#function" }, { "database": "UniProtKB", "id": "P58774", "url": "https://www.uniprot.org/uniprotkb/P58774#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q5KR48", "url": "https://www.uniprot.org/uniprotkb/Q5KR48" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TPM2", "url": "https://www.uniprot.org/uniprotkb/Q5KR48", "locus": { "chromosome": "8", "start_pos": 59855656, "end_pos": 59865990, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": 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CANONICAL=Q5KR48-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 108, "end_pos": 108, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q5KR48", "url": "https://www.uniprot.org/uniprotkb/Q5KR48" } ], "site_lbl": "Thr108" }, { "start_pos": 158, "end_pos": 158, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5KR48", "url": "https://www.uniprot.org/uniprotkb/Q5KR48" } ], "site_lbl": "Ser158" }, { "start_pos": 206, "end_pos": 206, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q5KR48", "url": "https://www.uniprot.org/uniprotkb/Q5KR48" } ], "site_lbl": "Ser206" }, { "start_pos": 215, "end_pos": 215, "kinase_uniprot_canonical_ac": "", 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"id": "15641772", "url": "https://glygen.org/publication/PubMed/15641772" } ] }, { "annotation": "Results from DNA and RNA sequence-based association mapping implicate MGST1, a gene with no obvious mechanistic relationship to milk composition regulation, as causally involved in these processes. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001007816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007816" }, { "database": "PubMed", "id": "27146958", "url": "https://glygen.org/publication/PubMed/27146958" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q64L89", "url": "https://www.uniprot.org/uniprotkb/Q64L89" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MGST1", "url": "https://www.uniprot.org/uniprotkb/Q64L89", "locus": { "chromosome": "5", "start_pos": 93497073, "end_pos": 93520490, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008541", "url": "https://www.ensembl.org/id/ENSBTAG00000008541" } ] } } ], "crossref": [ { "id": "Q64L89", "url": 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epithelium: protection against oxidative stress and a potential role in aging.", "journal": "Biochemistry", "date": "2005", "authors": "Maeda A, Crabb JW, Palczewski K", "evidence": [ { "database": "RefSeq", "id": "NP_001007816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007816" } ], "reference": [ { "type": "PubMed", "id": "15641772", "url": "https://glygen.org/publication/PubMed/15641772" } ] }, { "title": "Sequence-based Association Analysis Reveals an MGST1 eQTL with Pleiotropic Effects on Bovine Milk Composition.", "journal": "Scientific reports", "date": "2016-05-05", "authors": "Littlejohn Mathew D, Tiplady Kathryn, Fink Tania A, Lehnert Klaus, Lopdell Thomas, Johnson Thomas, Couldrey Christine, Keehan Mike, Sherlock Richard G, Harland Chad, Scott Andrew, Snell Russell G, Davis Stephen R, Spelman Richard J", "evidence": [ { "database": "RefSeq", "id": "NP_001007816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007816" } ], "reference": [ { "type": "PubMed", "id": 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"https://www.uniprot.org/uniprotkb/Q687Y7/entry#names_and_taxonomy" } ] }, { "name": "IL-17", "type": "synonym", "evidence": [ { "id": "Q687Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q687Y7/entry#names_and_taxonomy" } ] }, { "name": "interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)", "type": "synonym", "evidence": [ { "id": "NP_001008412", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008412" } ] }, { "name": "interleukin-17A precursor", "type": "synonym", "evidence": [ { "id": "NP_001008412", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008412" } ] } ], "function": [ { "annotation": "Calves, like humans, mount a robust IL-17 response during respiratory syncytial virus infection. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001008412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008412" }, { "database": "PubMed", "id": "26942409", "url": "https://glygen.org/publication/PubMed/26942409" } ] }, { "annotation": "Data show that CD4(+) and WC1(+) gammadelta T-cells were induced to produce IL-17 termed Th17 and gammadelta17 cells. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001008412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008412" }, { "database": "PubMed", "id": "24961164", "url": "https://glygen.org/publication/PubMed/24961164" } ] }, { "annotation": "Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines. In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells. Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance. Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation. Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis. As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release. In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers. Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. May play a beneficial role in influenza A virus (H5N1) infection by enhancing B cell recruitment and immune response in the lung. Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense.", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7#function" }, { "database": "UniProtKB", "id": "Q62386", "url": "https://www.uniprot.org/uniprotkb/Q62386#function" } ] }, { "annotation": "IL-17A and IL-17F have a potential to modulate the mammary gland immune response to mastitis-causing pathogens.", "evidence": [ { "database": "RefSeq", "id": "NP_001008412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008412" }, { "database": "PubMed", "id": "22004923", "url": "https://glygen.org/publication/PubMed/22004923" } ] }, { "annotation": "IL-17A was shown to be upregulated, supporting its investigation as a potential biomarker of bTB.", "evidence": [ { "database": "RefSeq", "id": "NP_001008412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008412" }, { "database": "PubMed", "id": "22909117", "url": "https://glygen.org/publication/PubMed/22909117" } ] }, { "annotation": "Our data suggests that Th17-like cells may indeed play a role in early immune responses to Mycobacterium avium sp. paratuberculosis infection and development or control of Johne's disease in cattle.", "evidence": [ { "database": "RefSeq", "id": "NP_001008412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008412" }, { "database": "PubMed", "id": "31593889", "url": "https://glygen.org/publication/PubMed/31593889" } ] }, { "annotation": "The results of this study provide evidence of the role of IL-17 in the immunopathology of tuberculosis and support the use of IL-17 as a potential biomarker with predictive value of prognosis in bTB.", "evidence": [ { "database": "RefSeq", "id": "NP_001008412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008412" }, { "database": "PubMed", "id": "21185783", "url": "https://glygen.org/publication/PubMed/21185783" } ] }, { "annotation": "These results support previous gene transcription studies and extend the observation of increased IL-22 and IL-17A responses in M. bovis-infected animals to the level of protein production. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001008412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008412" }, { "database": "PubMed", "id": "27427303", "url": "https://glygen.org/publication/PubMed/27427303" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL17A", "url": "https://www.uniprot.org/uniprotkb/Q687Y7", "locus": { "chromosome": "23", "start_pos": 24609483, "end_pos": 24605962, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002150", "url": "https://www.ensembl.org/id/ENSBTAG00000002150" } ] } } ], "crossref": [ { "id": "Q687Y7", "url": 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"sp|Q687Y7-1|IL17_BOVIN Isoform 1 of Interleukin-17A OS=Bos taurus OX=9913 GN=IL17A PE=2 SV=1 CANONICAL=Q687Y7-1" }, "isoforms": [ { "isoform_ac": "Q687Y7-1", "url": "https://www.uniprot.org/uniprotkb/Q687Y7/entry#Q687Y7-1", "sequence": { "sequence": "MASMRTSSMSLLLLLSLVALVKAGVIIPQSPGCPPTEDKNFPQHVRVNLNIVNRSTNSRRPTDYHKRSTSPWTLHRNEDPERYPSVIWEAKCSHSGCINAEGKVDHHMNSVTIQQEILVLRRESQHCPHSFRLEKMLVAVGCTCVTPIVRHLA", "length": 153, "header": "sp|Q687Y7-1|IL17_BOVIN Isoform 1 of Interleukin-17A OS=Bos taurus OX=9913 GN=IL17A PE=2 SV=1 CANONICAL=Q687Y7-1" }, "locus": { "chromosome": "23", "start_pos": 24608981, "end_pos": 24606019, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002786.4", "url": "https://www.ensembl.org/id/ENSBTAT00000002786.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002786.3", "url": "https://www.ensembl.org/id/ENSBTAP00000002786.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 53, "start_aa": "Asn", "end_pos": 53, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn53", "evidence": [ { "id": "Q687Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q687Y7#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Increased IL-17 expression is associated with pathology in a bovine model of tuberculosis.", "journal": "Tuberculosis (Edinburgh, Scotland)", "date": "2011-01", "authors": "Blanco Federico Carlos, Bianco Mar\u00eda Ver\u00f3nica, Meikle Virginia, Garbaccio Sergio, Vagnoni Lucas, Forrellad Marina, Klepp Laura In\u00e9s, Cataldi Angel Adri\u00e1n, Bigi Fabiana", "evidence": [ { "database": "RefSeq", "id": "NP_001008412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008412" } ], "reference": [ { "type": "PubMed", "id": "21185783", "url": "https://glygen.org/publication/PubMed/21185783" } ] }, { "title": "Staphylococcal-associated molecular patterns enhance expression of immune defense genes induced by IL-17 in mammary epithelial cells.", "journal": "Cytokine", "date": "2011-12", "authors": "Bougarn Salim, Cunha Patricia, Gilbert Florence B, Harmache Abdallah, Foucras Gilles, Rainard Pascal", "evidence": [ { "database": "RefSeq", "id": "NP_001008412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008412" } ], "reference": [ { "type": "PubMed", "id": "22004923", "url": "https://glygen.org/publication/PubMed/22004923" } ] }, { "title": "Upregulation of IL-17A, CXCL9 and CXCL10 in early-stage granulomas induced by Mycobacterium bovis in cattle.", "journal": "Transboundary and emerging diseases", "date": "2013-12", "authors": "Aranday-Cortes E, Bull N C, Villarreal-Ramos B, Gough J, Hicks D, Ortiz-Pel\u00e1ez A, Vordermeier H M, Salguero F J", "evidence": [ { "database": "RefSeq", "id": "NP_001008412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008412" } ], "reference": [ { "type": "PubMed", "id": "22909117", "url": "https://glygen.org/publication/PubMed/22909117" } ] }, { "title": "Two distinct populations of bovine IL-17\u207a T-cells can be induced and WC1\u207aIL-17\u207a\u03b3\u03b4 T-cells are effective killers of protozoan parasites.", "journal": "Scientific reports", "date": "2014-06-25", "authors": "Peckham R K, Brill R, Foster D S, Bowen A L, Leigh J A, Coffey T J, Flynn R J", "evidence": [ { "database": "RefSeq", "id": "NP_001008412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008412" } ], "reference": [ { "type": "PubMed", "id": "24961164", "url": "https://glygen.org/publication/PubMed/24961164" } ] }, { "title": "Bovine Gamma Delta T Cells Contribute to Exacerbated IL-17 Production in Response to Co-Infection with Bovine RSV and Mannheimia haemolytica.", "journal": "PloS one", "date": "2016", "authors": "McGill Jodi L, Rusk Rachel A, Guerra-Maupome Mariana, Briggs Robert E, Sacco Randy E", "evidence": [ { "database": "RefSeq", "id": "NP_001008412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008412" } ], "reference": [ { "type": "PubMed", "id": "26942409", "url": "https://glygen.org/publication/PubMed/26942409" } ] }, { "title": "CD4+ and \u03b3\u03b4 T Cells are the main Producers of IL-22 and IL-17A in Lymphocytes from Mycobacterium bovis-infected Cattle.", "journal": "Scientific reports", "date": "2016-07-18", "authors": "Steinbach Sabine, Vordermeier H Martin, Jones Gareth J", "evidence": [ { "database": "RefSeq", "id": "NP_001008412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008412" } ], "reference": [ { "type": "PubMed", "id": "27427303", "url": "https://glygen.org/publication/PubMed/27427303" } ] }, { "title": "Mycobacterium avium sp. paratuberculosis (MAP) induces IL-17a production in bovine peripheral blood mononuclear cells (PBMCs) and enhances IL-23R expression in-vivo and in-vitro.", "journal": "Veterinary immunology and immunopathology", "date": "2019-12", "authors": "DeKuiper Justin L, Coussens Paul M", "evidence": [ { "database": "RefSeq", "id": "NP_001008412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008412" } ], "reference": [ { "type": "PubMed", "id": "31593889", "url": "https://glygen.org/publication/PubMed/31593889" } ] } ], "pathway": [ { "id": "bta:282863", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282863", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3I1H2-1", "protein_name": "Interleukin-17A", "gene_name": "Il17a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSPGRTSSVSLLLLLLLSLEAVVKAGLPIPQSSECPNTEAKNFLQNVKVNLKVLNSLSPKVNSRRPSDYLNRSTSPWTLRRNEDPDRYPSVIWEAECRHQRCVNAEGKLDHHMNSVLIQQEILVLRREPENCPVSFRMEKMLVGVGCTCVSSIVRHVA", "length": 158 }, "evidence": [ { "id": "Q687Y7", "url": "https://omabrowser.org/oma/group/Q687Y7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q16552-1", "protein_name": "Interleukin-17A", "gene_name": "IL17A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA", "length": 155 }, "evidence": [ { "id": "Q687Y7", "url": "https://omabrowser.org/oma/group/Q687Y7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q61453-1", "protein_name": "Interleukin-17A", "gene_name": "Il17a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCLMLLLLLNLEATVKAAVLIPQSSVCPNAEANNFLQNVKVNLKVINSLSSKASSRRPSDYLNRSTSPWTLSRNEDPDRYPSVIWEAQCRHQRCVNAEGKLDHHMNSVLIQQEILVLKREPEKCPFTFRVEKMLVGVGCTCVSSIVRHAS", "length": 150 }, "evidence": [ { "id": "Q687Y7", "url": "https://omabrowser.org/oma/group/Q687Y7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q62386-1", "protein_name": "Interleukin-17A", "gene_name": "Il17a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSPGRASSVSLMLLLLLSLAATVKAAAIIPQSSACPNTEAKDFLQNVKVNLKVFNSLGAKVSSRRPSDYLNRSTSPWTLHRNEDPDRYPSVIWEAQCRHQRCVNAEGKLDHHMNSVLIQQEILVLKREPESCPFTFRVEKMLVGVGCTCVASIVRQAA", "length": 158 }, "evidence": [ { "id": "Q687Y7", "url": "https://omabrowser.org/oma/group/Q687Y7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 24, "go_terms": [ { "name": "positive regulation of interleukin-23 production", "id": "GO:0032747", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032747", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "Notch signaling pathway", "id": "GO:0007219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "defense response to Gram-negative bacterium", "id": "GO:0050829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050829", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "defense response 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response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "defense response to fungus", "id": "GO:0050832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050832", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "fibroblast activation", "id": "GO:0072537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072537", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "intestinal epithelial structure maintenance", "id": "GO:0060729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060729", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "gene expression", "id": "GO:0010467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010467", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "positive regulation of osteoclast differentiation", "id": "GO:0045672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045672", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "keratinocyte proliferation", "id": "GO:0043616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043616", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "positive regulation of bicellular tight junction assembly", "id": "GO:1903348", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903348", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "positive regulation of chemokine (C-X-C motif) ligand 1 production", "id": "GO:2000340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000340", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "granulocyte migration", "id": "GO:0097530", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097530", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "interleukin-17A-mediated signaling pathway", "id": "GO:0038173", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038173", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "negative regulation of inflammatory response to wounding", "id": "GO:0106015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106015", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "interleukin-17-mediated signaling pathway", "id": "GO:0097400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097400", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "regulation of primary metabolic process", "id": "GO:0080090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080090", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "positive regulation of antimicrobial peptide production", "id": "GO:0002225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002225", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" }, { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "Q687Y7", "url": "https://www.uniprot.org/uniprotkb/Q687Y7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q687Y7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 153, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q687Y7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q687Y7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 53 ], 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"https://www.uniprot.org/uniprotkb/Q6A198/entry#names_and_taxonomy" } ] }, { "name": "Fucosyltransferase X", "type": "synonym", "evidence": [ { "id": "Q6A198", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6A198/entry#names_and_taxonomy" } ] }, { "name": "GDP-fucose protein O-fucosyltransferase 3 precursor", "type": "synonym", "evidence": [ { "id": "NP_892032", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_892032" } ] }, { "name": "GDP-fucose protein O-fucosyltransferase 3", "type": "synonym", "evidence": [ { "id": "NP_892032", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_892032" } ] }, { "name": "Galactoside 3-L-fucosyltransferase 10", "type": "synonym", "evidence": [ { "id": "Q6A198", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6A198/entry#names_and_taxonomy" } ] }, { "name": "alpha-(1,3)-fucosyltransferase 10", "type": "synonym", "evidence": [ { "id": "NP_892032", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_892032" } ] }, { "name": "alpha-3-fucosyltransferase FUT10", "type": "synonym", "evidence": [ { "id": "NP_892032", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_892032" } ] }, { "name": "fuc-TX", "type": "synonym", "evidence": [ { "id": "NP_892032", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_892032" } ] }, { "name": "fucT-X", "type": "synonym", "evidence": [ { "id": "NP_892032", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_892032" } ] }, { "name": "fucosyltransferase 10 (alpha (1,3) fucosyltransferase)", "type": "synonym", "evidence": [ { "id": "NP_892032", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_892032" } ] }, { "name": "fucosyltransferase X", "type": "synonym", "evidence": [ { "id": "NP_892032", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_892032" } ] }, { "name": "galactoside 3-L-fucosyltransferase 10", "type": "synonym", "evidence": [ { "id": "NP_892032", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_892032" } ] } ], "function": [ { "annotation": "Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1. Attaches fucose through an O-glycosidic linkage. O-fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion. May also show alpha-(1,3)-fucosyltransferase activity toward the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. However, this was tested with a library of synthetic substrates and this activity is unsure in vivo (By similarity). May be involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q6A198", "url": "https://www.uniprot.org/uniprotkb/Q6A198#function" }, { "database": "UniProtKB", "id": "Q6P4F1", "url": "https://www.uniprot.org/uniprotkb/Q6P4F1#function" }, { "database": "UniProtKB", "id": "Q5F2L2", "url": "https://www.uniprot.org/uniprotkb/Q5F2L2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6A198", "url": "https://www.uniprot.org/uniprotkb/Q6A198" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "POFUT3", "url": "https://www.uniprot.org/uniprotkb/Q6A198", "locus": {} } ], "crossref": [ { "id": "Q6A198", "url": "https://alphafold.ebi.ac.uk/entry/Q6A198", "database": "AlphaFoldDB", "categories": [] }, { "id": "360195", "url": "https://www.ncbi.nlm.nih.gov/gene/360195", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001503", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001503", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017176", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017176", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031481", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031481", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055270", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055270", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:360195", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:360195", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q6A198", "url": "https://www.orthodb.org/?gene=Q6A198", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11929", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11929", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11929:SF194", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11929:SF194", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00852", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00852", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17039", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17039", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_892032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_892032", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "63644", "url": "https://www.rhea-db.org/rhea/63644", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "70491", "url": "https://www.rhea-db.org/rhea/70491", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q6A198", "url": "https://www.uniprot.org/uniprotkb/Q6A198", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6A198-1", "url": "https://www.uniprot.org/uniprotkb/Q6A198-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRIQRGKLLAFCLCVMATVFLLITLQVVVELGKFEGKKFKNSHLKDGHAQMEAEPLHLHPFFNREGLTLNRKKTLAADSFPIMLWWSPLTGETGRLGQCGADACFFTINRTYLHHHRTKAFLFYGTDFSIDSLPLPRKAHHDWALFHEESPKNNYKLFHQPVITLFNYTATFSRHSHLPLTTQYLEGTEVLTSLRHLVPLRSKNHLRKSLAPLVYVQSDCDPPSDRDSYVRELMTYIEVDSYGECLRNKPLPPQLSNPASMDADGFFRILAQYKFILAFENAVCDDYITEKLWRPLKLGVVPVYYGSPSIADWLPSNRSAILVSEFSHPRELASYIRALDRDDRRYQAYIEWKLKGEISNQRLLTALRERKWGVQDVKQDNYIDAFECMVCTKVWDNIRLQEKGLPPKRWQADVTHLSCPEPTVFAFSPLVPRRRSLREMWIPSFQQSKKEARALRWLVDRNQNFSTQEFWALVFKD", "length": 478, "header": "sp|Q6A198-1|OFUT3_BOVIN Isoform 1 of GDP-fucose protein O-fucosyltransferase 3 OS=Bos taurus OX=9913 GN=POFUT3 PE=2 SV=1 CANONICAL=Q6A198-1" }, "isoforms": [ { "isoform_ac": "Q6A198-1", "url": "https://www.uniprot.org/uniprotkb/Q6A198/entry#Q6A198-1", "sequence": { "sequence": "MVRIQRGKLLAFCLCVMATVFLLITLQVVVELGKFEGKKFKNSHLKDGHAQMEAEPLHLHPFFNREGLTLNRKKTLAADSFPIMLWWSPLTGETGRLGQCGADACFFTINRTYLHHHRTKAFLFYGTDFSIDSLPLPRKAHHDWALFHEESPKNNYKLFHQPVITLFNYTATFSRHSHLPLTTQYLEGTEVLTSLRHLVPLRSKNHLRKSLAPLVYVQSDCDPPSDRDSYVRELMTYIEVDSYGECLRNKPLPPQLSNPASMDADGFFRILAQYKFILAFENAVCDDYITEKLWRPLKLGVVPVYYGSPSIADWLPSNRSAILVSEFSHPRELASYIRALDRDDRRYQAYIEWKLKGEISNQRLLTALRERKWGVQDVKQDNYIDAFECMVCTKVWDNIRLQEKGLPPKRWQADVTHLSCPEPTVFAFSPLVPRRRSLREMWIPSFQQSKKEARALRWLVDRNQNFSTQEFWALVFKD", "length": 478, "header": "sp|Q6A198-1|OFUT3_BOVIN Isoform 1 of GDP-fucose protein O-fucosyltransferase 3 OS=Bos taurus OX=9913 GN=POFUT3 PE=2 SV=1 CANONICAL=Q6A198-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 110, "start_aa": "Asn", "end_pos": 110, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn110", "evidence": [ { "id": "Q6A198", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6A198#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 168, "start_aa": "Asn", "end_pos": 168, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn168", "evidence": [ { "id": "Q6A198", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6A198#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycosyltransferase-activity", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q6A198", "url": "https://www.uniprot.org/uniprotkb/Q6A198" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:360195", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:360195", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "peptide-O-fucosyltransferase activity", "id": "GO:0046922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046922", "evidence": [ { "database": "UniProtKB", "id": "Q6A198", "url": "https://www.uniprot.org/uniprotkb/Q6A198" } ], "pmid": "" }, { "name": "fucosyltransferase activity", "id": "GO:0008417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008417", "evidence": [ { "database": "UniProtKB", "id": "Q6A198", "url": "https://www.uniprot.org/uniprotkb/Q6A198" } ], "pmid": "" }, { "name": "alpha-(1->3)-fucosyltransferase activity", "id": "GO:0046920", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046920", "evidence": [ { "database": "UniProtKB", "id": "Q6A198", "url": "https://www.uniprot.org/uniprotkb/Q6A198" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q6A198", "url": "https://www.uniprot.org/uniprotkb/Q6A198" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q6A198", "url": "https://www.uniprot.org/uniprotkb/Q6A198" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q6A198", "url": "https://www.uniprot.org/uniprotkb/Q6A198" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of protein secretion", "id": "GO:0050714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050714", "evidence": [ { "database": "UniProtKB", "id": "Q6A198", "url": "https://www.uniprot.org/uniprotkb/Q6A198" } ], "pmid": "" }, { "name": "N-glycan processing", "id": "GO:0006491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006491", "evidence": [ { "database": "UniProtKB", "id": "Q6A198", "url": "https://www.uniprot.org/uniprotkb/Q6A198" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 168, "end_pos": 170, "annotation": "n_glycosylation_sequon" }, { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" }, { "start_pos": 465, "end_pos": 467, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "63644", "name": "", "equation": "L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0ABI0P7D0-1", "A0A3Q1MQ73-1", "Q6A198-1", "F1N557-1", "A0AAA9S1Q8-1" ], "evidence": [ { "id": "63644", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/63644" } ] }, { "id": "70491", "name": "", "equation": "L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0ABI0P7D0-1", "A0A3Q1MQ73-1", "Q6A198-1", "F1N557-1", "A0AAA9S1Q8-1" ], "evidence": [ { "id": "70491", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70491" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MQ73", "gene_name": "POFUT1", "activity": [ { "ec_number": "2.4.1.221", "activity": "L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+).", "evidence": [ { "id": "A0A3Q1MQ73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQ73" } ] }, { "ec_number": "2.4.1.221", "activity": "", "evidence": [ { "id": "A0A3Q1MQ73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQ73" } ] } ] }, { "uniprot_ac": "A0AAA9S1Q8", "gene_name": "FUT11", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0AAA9S1Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Q8" } ] } ] }, { "uniprot_ac": "A0ABI0P7D0", "gene_name": "POFUT2", "activity": [ { "ec_number": "2.4.1.221", "activity": "L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+).", "evidence": [ { "id": "A0ABI0P7D0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P7D0" } ] }, { "ec_number": "2.4.1.221", "activity": "", "evidence": [ { "id": "A0ABI0P7D0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P7D0" } ] } ] }, { "uniprot_ac": "F1N557", "gene_name": "FUT10", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F1N557", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N557" } ] } ] }, { "uniprot_ac": "Q6A198", "gene_name": "POFUT3", "activity": [ { "ec_number": "2.4.1.221", "activity": "L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+).", "evidence": [ { "id": "Q6A198", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6A198" } ] }, { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q6A198", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6A198" } ] }, { "ec_number": "2.4.1.221", "activity": "", "evidence": [ { "id": "Q6A198", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6A198" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q6A198-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 478, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q6A198-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q6A198" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [ { "glytoucan_ac": "G00113FP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G00210ZX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G00301IL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00438EF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00464AQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G00471UP", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G00560KG", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00584LL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G00606LX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G00706QN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G00707RC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00728SN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00754TS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00828CZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G00901NZ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G00978GW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01001RL", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G01092NQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G01169EW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G01243KR", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G01342FO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G01357LV", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01454UB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G01471GI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01522FD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G01553JA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G01744JD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G01747FB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G01823EY", "type": "O-linked", "subtype": "O-mannose core M1" }, { "glytoucan_ac": "G01863JX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G01912GF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G01922RI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G02025MF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G02076VP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G02150AC", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02175PZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G02230VA", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G02370LQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G02377RY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02427KF", "type": "N-linked", "subtype": "Arm-fucosylated" }, { "glytoucan_ac": "G02429WR", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G02441OB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G02442MH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G02494HC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G02522JF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G02786XX", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G02841EM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G03008IO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G03016BW", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G03019AY", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G03093CG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G03177DI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G03266UM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03272YQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G03304QB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03319HQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G03340FG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G03404VQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G03462LS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03484HH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G03591CN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G03708WQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G03792OA", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G03852KN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G03855LZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G03893BA", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G03962UN", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G04002YJ", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G04014FP", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G04078TP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G04114CX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04453SY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G04501IZ", "type": "N-linked", "subtype": "Arm-fucosylated" }, { "glytoucan_ac": "G04506OA", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G04638IX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G04702UE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G04703AJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G04744RZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G04751SB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G05024RF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G05028TR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05081PF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G05081RC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G05107UT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G05121JM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G05143WC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G05245MQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G05250QH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G05343DC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G05378UG", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G05395ZW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G05400IQ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05456PR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05470LY", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G05570RS", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G05667QP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G05690OR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G05862XJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G06067PC", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G06194HJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G06255HU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G06314LQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G06374YY", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G06439PI", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G06477WS", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G06523WI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06593KR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06595MR", "type": "O-linked", "subtype": "O-mannose core M1" }, { "glytoucan_ac": "G06661NM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G06662ZP", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06731AE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G06786CI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G06945SR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G06966YC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G07041CT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G07140RV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G07209EH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G07221OX", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G07233JN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G07410QH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G07478HN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G07492AS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G07528DS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G07572HP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G07595NQ", "type": "O-linked", "subtype": "O-mannose core, other" }, { "glytoucan_ac": "G07639BG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G07646UD", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G07810DU", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G07815PK", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G07865ET", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G07909FX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G07913PZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G07920XA", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G08059ZN", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G08076GV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G08083RQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G08107SW", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G08111FJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G08162SW", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G08190JB", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G08201TX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08264JX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08366OY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G08496HZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G08597BP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G08866CW", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G08896RO", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G08923JC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G09009DV", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G09022KY", "type": "N-linked", "subtype": "Arm-fucosylated" }, { "glytoucan_ac": "G09058KZ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G09095MV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G09128UQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G09142NP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G09255AF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G09263FO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G09403AR", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G09424UT", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G09453OL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G09520ZQ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G09538AR", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G09605DV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G09678FF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G09767ET", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G09777HT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G09781FH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10223RO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G10240SH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G10409DZ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G10463IQ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G10487BH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10507XI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G10537HU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G10580RD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G10604KJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10608NX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10641UB", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G10716SX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G10765FQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G10807RQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G10843VM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G10852MU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G10907RR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G10954DW", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G10993EM", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G11061EX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G11102NL", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G11107QZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G11120EJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11192EU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G11208SX", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G11286QT", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G11287YT", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G11318UD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G11551UU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G11699WH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11762BM", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G11846US", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11848VF", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11889PN", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11907PK", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G11983UH", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G12111NA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12114XT", "type": "O-linked", "subtype": "Core 6" }, { "glytoucan_ac": "G12146BU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G12188JQ", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G12350CH", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G12405JG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G12524BD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G12545NN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G12788IH", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G12894CE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G12902VJ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G12933YP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G12986NJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G13077RN", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G13101AX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13315PT", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G13382WY", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G13496UJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13521NM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G13628SS", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G13634RR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G13646GG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G13663YA", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G13684QB", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13688QP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G13745OH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G13785BU", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13816ZL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13865MD", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G13894RO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G13939BK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G13985ZF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G14047MI", "type": "N-linked", "subtype": "Bisected" }, { "glytoucan_ac": "G14054GG", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G14057WB", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G14077SN", "type": "N-linked", "subtype": "Tetraantennary" }, { 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}, { "glytoucan_ac": "G15216UP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G15249CA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15268QU", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G15522RV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G15577DT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G15635CJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G15772KA", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G15860LG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G16042LM", "type": "N-linked", "subtype": "Arm-fucosylated" }, { "glytoucan_ac": "G16086VT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16157DW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16270SN", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G16289YK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16335FI", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G16433RL", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G16441MS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G16451PE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16476DW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G16502PF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G16536QD", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G16552HD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G16614GV", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G16753NR", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G16767XC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G16776JC", "type": "N-linked", "subtype": "Arm-fucosylated" }, { "glytoucan_ac": "G16798QB", "type": 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3" }, { "glytoucan_ac": "G35367DM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G35452GG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G35455VF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G35528EA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G35623XW", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G35724PH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G35734MQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G35747ZX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G35811WM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G35815ZB", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G35872TD", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G35878KK", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G35929YH", "type": "N-linked", 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"G53520XD", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G53527TY", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G53709ZS", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G53738ZH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53809CJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53889SN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G53894HD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G54083SI", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G54133WC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G54278AD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G54278DQ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G54312CD", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G54409FD", "type": "O-linked", "subtype": "Core 2" }, { 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"G55157XP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G55174HS", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55205VX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55314RK", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G55397SP", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G55413YQ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G55453IK", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G55636WA", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55638XL", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55773UK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G55870EJ", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55880FX", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G55886TV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G55914FN", "type": 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"Q6B411", "url": "https://www.orthodb.org/?gene=Q6B411", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11407", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11407", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11407:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11407:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00062", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00062", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071297", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q6B411", "url": "https://www.uniprot.org/uniprotkb/Q6B411", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6B411-1", "url": "https://www.uniprot.org/uniprotkb/Q6B411-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKALLIVGLLLLSVAVQGKKFQRCELARTLKKLGLDGYRGVSLANWVCLARWESNYNTRATNYNRGDKSTDYGIFQINSRWWCNDGKTPKAVNACRIPCSALLKDDITQAVACAKRVVRDPQGIKAWVAWRNKCQNRDLRSYVQGCRV", "length": 148, "header": "sp|Q6B411-1|LYSM_BOVIN Isoform 1 of Lysozyme C, milk isozyme OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q6B411-1" }, "isoforms": [ { "isoform_ac": "Q6B411-1", "url": "https://www.uniprot.org/uniprotkb/Q6B411/entry#Q6B411-1", "sequence": { "sequence": "MKALLIVGLLLLSVAVQGKKFQRCELARTLKKLGLDGYRGVSLANWVCLARWESNYNTRATNYNRGDKSTDYGIFQINSRWWCNDGKTPKAVNACRIPCSALLKDDITQAVACAKRVVRDPQGIKAWVAWRNKCQNRDLRSYVQGCRV", "length": 148, "header": "sp|Q6B411-1|LYSM_BOVIN Isoform 1 of Lysozyme C, milk isozyme OS=Bos taurus OX=9913 GN= PE=2 SV=1 CANONICAL=Q6B411-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycohydrolase-activity" ], "publication": [ { "title": "Evolution of cow nonstomach lysozyme genes.", "journal": "Genome", "date": "2004", "authors": "Irwin David M", "evidence": [ { "database": "UniProtKB", "id": "Q6B411", "url": "https://www.uniprot.org/uniprotkb/Q6B411" } ], "reference": [ { "type": "PubMed", "id": "15644966", "url": "https://glygen.org/publication/PubMed/15644966" } ] } ], "pathway": [ { "id": "bta:281287", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281287", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P37160-1", "protein_name": "Lysozyme S", "gene_name": "LysS", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MKAFFALVLLAIAAPALAGRTLDRCSLAREMADLGVPRDQLDKWTCIAQHESDYRTWVVGPANSDGSNDYGIFQINDLYWCQADGRFSYNECGLSCNALLTDDITNSVRCAQKVLSQQGWSAWAVWHYCSGWLPSIDECF", "length": 140 }, "evidence": [ { "id": "Q6B411", "url": "https://omabrowser.org/oma/group/Q6B411/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q6B411", "url": "https://www.uniprot.org/uniprotkb/Q6B411" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "defense response to Gram-negative bacterium", "id": "GO:0050829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050829", "evidence": [ { "database": "UniProtKB", "id": "Q6B411", "url": "https://www.uniprot.org/uniprotkb/Q6B411" } ], "pmid": "" }, { "name": "defense response to Gram-positive bacterium", "id": "GO:0050830", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050830", "evidence": [ { "database": "UniProtKB", "id": "Q6B411", "url": "https://www.uniprot.org/uniprotkb/Q6B411" } ], "pmid": "" }, { "name": "killing of cells of another organism", "id": "GO:0031640", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031640", "evidence": [ { "database": "UniProtKB", "id": "Q6B411", "url": "https://www.uniprot.org/uniprotkb/Q6B411" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lysozyme activity", "id": "GO:0003796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003796", "evidence": [ { "database": "UniProtKB", "id": "Q6B411", "url": "https://www.uniprot.org/uniprotkb/Q6B411" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q6B411-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 148, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q6B411-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q6B411" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q6B411", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6B411" }, { "id": "PRU00680", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00680" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C-type lysozyme", "eco_id": "ECO_0000255", "start_pos": 19, "end_pos": 148, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.2.1.17", "ec_name": "Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.", "evidence": [ { "id": "3.2.1.17", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.2.1.17" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q6B4J2-1", "uniprot_ac": "Q6B4J2", "uniprot_id": "VKOR1_BOVIN", "mass": { "chemical_mass": 17967.0, "monoisotopic_mass": 17967.0 }, "refseq": { "ac": "NP_001003903", "name": "vitamin K epoxide reductase complex subunit 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003903" }, "gene_names": [ { "name": "VKORC1", "type": "recommended", "evidence": [ { "id": "Q6B4J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6B4J2" } ] }, { "name": "VKORC1", "type": "synonym", "evidence": [ { "id": "NP_001003903", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003903" } ] } ], "protein_names": [ { "name": "Vitamin K epoxide reductase complex subunit 1", "type": "recommended", "evidence": [ { "id": "Q6B4J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6B4J2/entry#names_and_taxonomy" } ] }, { "name": "1.17.4.4", "type": "synonym", "evidence": [ { "id": "Q6B4J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6B4J2/entry#names_and_taxonomy" } ] }, { "name": "Vitamin K1 2,3-epoxide reductase subunit 1", "type": "synonym", "evidence": [ { "id": "Q6B4J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6B4J2/entry#names_and_taxonomy" } ] }, { "name": "vitamin K epoxide reductase complex subunit 1", "type": "synonym", "evidence": [ { "id": "NP_001003903", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003903" } ] }, { "name": "vitamin K1 2,3-epoxide reductase subunit 1", "type": "synonym", "evidence": [ { "id": "NP_001003903", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003903" } ] } ], "function": [ { "annotation": "Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.", "evidence": [ { "database": "UniProtKB", "id": "Q6B4J2", "url": "https://www.uniprot.org/uniprotkb/Q6B4J2#function" }, { "database": "UniProtKB", "id": "Q9BQB6", "url": "https://www.uniprot.org/uniprotkb/Q9BQB6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6B4J2", "url": "https://www.uniprot.org/uniprotkb/Q6B4J2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VKORC1", "url": "https://www.uniprot.org/uniprotkb/Q6B4J2", "locus": { "chromosome": "25", "start_pos": 27200500, "end_pos": 27203455, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000405", "url": "https://www.ensembl.org/id/ENSBTAG00000000405" } ] } } ], "crossref": [ { "id": "Q6B4J2", "url": "https://alphafold.ebi.ac.uk/entry/Q6B4J2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000405", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000405", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12917", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12917", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL3212", "url": "https://www.ebi.ac.uk/chembl/target/inspect/CHEMBL3212", "database": "ChEMBL", "categories": [ "Chemical" ] }, { "id": "445422", "url": "https://www.ncbi.nlm.nih.gov/gene/445422", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012932", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012932", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038354", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038354", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042406", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042406", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:445422", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:445422", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YVINFAL", "url": "https://omabrowser.org/oma/group/YVINFAL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q6B4J2", "url": "https://www.orthodb.org/?gene=Q6B4J2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14519", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14519", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14519:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14519:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07884", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07884", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6806664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6806664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001003903", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003903", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13817", "url": "https://www.rhea-db.org/rhea/13817", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "57744", "url": "https://www.rhea-db.org/rhea/57744", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q6B4J2", "url": "https://www.uniprot.org/uniprotkb/Q6B4J2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6B4J2-1", "url": "https://www.uniprot.org/uniprotkb/Q6B4J2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGATWRSPGWVRLALCLAGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGKDSILNQSNSIFGCIFYTLQLLLGCLQGRWASVLLRLSCLVSLAGSVYLAWILFFVLYDFCIVCITTYAINVGLTVLSFREVQGPQGKVKGH", "length": 163, "header": "sp|Q6B4J2-1|VKOR1_BOVIN Isoform 1 of Vitamin K epoxide reductase complex subunit 1 OS=Bos taurus OX=9913 GN=VKORC1 PE=2 SV=1 CANONICAL=Q6B4J2-1" }, "isoforms": [ { "isoform_ac": "Q6B4J2-1", "url": "https://www.uniprot.org/uniprotkb/Q6B4J2/entry#Q6B4J2-1", "sequence": { "sequence": "MGATWRSPGWVRLALCLAGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGKDSILNQSNSIFGCIFYTLQLLLGCLQGRWASVLLRLSCLVSLAGSVYLAWILFFVLYDFCIVCITTYAINVGLTVLSFREVQGPQGKVKGH", "length": 163, "header": "sp|Q6B4J2-1|VKOR1_BOVIN Isoform 1 of Vitamin K epoxide reductase complex subunit 1 OS=Bos taurus OX=9913 GN=VKORC1 PE=2 SV=1 CANONICAL=Q6B4J2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:445422", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:445422", "resource": "KEGG Pathway" }, { "id": "R-BTA-6806664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6806664", "resource": "Reactome", "description": "Metabolism of vitamin K" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1TJA8-1", "protein_name": "vitamin-K-epoxide reductase (warfarin-sensitive)", "gene_name": "VKORC1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGTTWRNPGWVRFALCLAGLVLSLYALHVKAARARDRNYRALCDVGTAISCSRVFSSRWGQGFGLVEQVLGKDSVLNQSNSIFGCIFYTLQLLLGCLRGRWASVLLVLSSLVSLAGSVYLAWILFFVLYDFCIVCLTTYAINLGLMVLSFREMQGPQSKVKEH", "length": 163 }, "evidence": [ { "id": "Q6B4J2", "url": "https://omabrowser.org/oma/group/Q6B4J2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A1ZAJ5-1", "protein_name": "vitamin-K-epoxide reductase (warfarin-sensitive)", "gene_name": "Vkor", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEQAYSTASRLRGICVCGLAISVYSLYVKMKLKEDENYRPMCDVNDNISCSLVFKSGYGDGFGLGNITQVNAPNGAIGCAFYILYFLSSFFNHRWLCLVQLIVCTLTLLLCVYLGFLLILVFYDFCLVCVTIYFIHTWLFQEVLRRYRRLYM", "length": 152 }, "evidence": [ { "id": "Q6B4J2", "url": "https://omabrowser.org/oma/group/Q6B4J2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "E7F6X2-1", "protein_name": "vitamin-K-epoxide reductase (warfarin-sensitive)", "gene_name": "vkorc1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSSHSASGVPKWEFRVRLILCILGLVLSVYALHVELSRENNPEYRAMCDLGNSVSCSKVFTSRWGRGFGLVQIFTSKDSVLNQPNSVLGIIFYTLQLGLGQTVSSRAGFFLVMSSWVSVAGSVYLASILAFVLGDFCVVCVSTYIINFALLYTNLKRRTGLEARLKKGKSQ", "length": 171 }, "evidence": [ { "id": "Q6B4J2", "url": "https://omabrowser.org/oma/group/Q6B4J2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3I7D1-1", "protein_name": "vitamin-K-epoxide reductase (warfarin-sensitive)", "gene_name": "Vkorc1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGTTWRSPGRRRLALCLAGLALSLYALHVKAARARDEDYRALCDVGTAISCSRVFSSRWGKGFGLVEHVLGSDSVLNQSNSIFGCIFYTIQLLLGCLRGRWASLLLVLSSLVSFAGSVYLAWILFFVLYDFCIVCITTYAINVGLMLLNFQEVPEHKAKRP", "length": 161 }, "evidence": [ { "id": "Q6B4J2", "url": "https://omabrowser.org/oma/group/Q6B4J2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6TEK4-1", "protein_name": "Vitamin K epoxide reductase complex subunit 1", "gene_name": "Vkorc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGTTWRSPGRLRLALCLAGLALSLYALHVKAARARNEDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGADSILNQSNSIFGCMFYTIQLLLGCLRGRWASILLILSSLVSVAGSLYLAWILFFVLYDFCIVCITTYAINAGLMLLSFQKVPEHKVKKP", "length": 161 }, "evidence": [ { "id": "Q6B4J2", "url": "https://omabrowser.org/oma/group/Q6B4J2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9BQB6-1", "protein_name": "Vitamin K epoxide reductase complex subunit 1", "gene_name": "VKORC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYLAWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH", "length": 163 }, "evidence": [ { "id": "Q6B4J2", "url": "https://omabrowser.org/oma/group/Q6B4J2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "vitamin-K-epoxide reductase (warfarin-sensitive) activity", "id": "GO:0047057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047057", "evidence": [ { "database": "UniProtKB", "id": "Q6B4J2", "url": "https://www.uniprot.org/uniprotkb/Q6B4J2" } ], "pmid": "" }, { "name": "quinone binding", "id": "GO:0048038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048038", "evidence": [ { "database": "UniProtKB", "id": "Q6B4J2", "url": "https://www.uniprot.org/uniprotkb/Q6B4J2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q6B4J2", "url": "https://www.uniprot.org/uniprotkb/Q6B4J2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "blood coagulation", "id": "GO:0007596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596", "evidence": [ { "database": "UniProtKB", "id": "Q6B4J2", "url": "https://www.uniprot.org/uniprotkb/Q6B4J2" } ], "pmid": "" }, { "name": "bone development", "id": "GO:0060348", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060348", "evidence": [ { "database": "UniProtKB", "id": "Q6B4J2", "url": "https://www.uniprot.org/uniprotkb/Q6B4J2" } ], "pmid": "" }, { "name": "peptidyl-glutamic acid carboxylation", "id": "GO:0017187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017187", "evidence": [ { "database": "UniProtKB", "id": "Q6B4J2", "url": "https://www.uniprot.org/uniprotkb/Q6B4J2" } ], "pmid": "" }, { "name": "vitamin K metabolic process", "id": "GO:0042373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042373", "evidence": [ { "database": "UniProtKB", "id": "Q6B4J2", "url": "https://www.uniprot.org/uniprotkb/Q6B4J2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13817", "name": "", "equation": "phylloquinone + [protein]-disulfide + H2O = 2,3-epoxyphylloquinone + [protein]-dithiol", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6B4J2-1" ], "evidence": [ { "id": "13817", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13817" } ] }, { "id": "57744", "name": "", "equation": "phylloquinol + [protein]-disulfide = phylloquinone + [protein]-dithiol", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6B4J2-1" ], "evidence": [ { "id": "57744", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/57744" } ] }, { "id": "R-BTA-159790", "name": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6B4J2-1" ], "evidence": [ { "id": "R-BTA-159790", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159790" } ] }, { "id": "R-BTA-9026967", "name": "VKORC1 inhibitors binds VKORC1 dimer", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6B4J2-1" ], "evidence": [ { "id": "R-BTA-9026967", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9026967" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q6B4J2", "gene_name": "VKORC1", "activity": [ { "ec_number": "1.17.4.4", "activity": "phylloquinol + [protein]-disulfide = phylloquinone + [protein]-dithiol.", "evidence": [ { "id": "Q6B4J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6B4J2" } ] }, { "ec_number": "1.17.4.4", "activity": "", "evidence": [ { "id": "Q6B4J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6B4J2" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q6B4J2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 163, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q6B4J2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q6B4J2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.17.4.4", "ec_name": "phylloquinol + [protein]-disulfide = phylloquinone + [protein]-dithiol.", "evidence": [ { "id": "1.17.4.4", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.17.4.4" }, { "id": "1.17.4.4", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.17.4.4" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q6B855-1", "uniprot_ac": "Q6B855", "uniprot_id": "TKT_BOVIN", "mass": { "chemical_mass": 67906.0, "monoisotopic_mass": 67906.0 }, "refseq": { "ac": "NP_001003906", "name": "transketolase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003906" }, "gene_names": [ { "name": "TKT", "type": "recommended", "evidence": [ { "id": "Q6B855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6B855" } ] }, { "name": "TKT1", "type": "synonym", "evidence": [ { "id": "Q6B855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6B855" } ] }, { "name": "TKT", "type": "synonym", "evidence": [ { "id": "NP_001003906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003906" } ] } ], "protein_names": [ { "name": "Transketolase", "type": "recommended", "evidence": [ { "id": "Q6B855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6B855/entry#names_and_taxonomy" } ] }, { "name": "2.2.1.1", "type": "synonym", "evidence": [ { "id": "Q6B855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6B855/entry#names_and_taxonomy" } ] }, { "name": "TK", "type": "synonym", "evidence": [ { "id": "NP_001003906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003906" }, { "id": "Q6B855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6B855/entry#names_and_taxonomy" } ] }, { "name": "transketolase (Wernicke-Korsakoff syndrome)", "type": "synonym", "evidence": [ { "id": "NP_001003906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003906" } ] }, { "name": "transketolase", "type": "synonym", "evidence": [ { "id": "NP_001003906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003906" } ] } ], "function": [ { "annotation": "Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (By similarity). Thus, catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate (By similarity). The phosphate group of the substrate plays a role in stabilizing the substrate-thiamine intermediate while preventing the formation of the reactive enamine intermediate (By similarity). Can also use fructose-6-phosphate as a ketose donor (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q6B855", "url": "https://www.uniprot.org/uniprotkb/Q6B855#function" }, { "database": "UniProtKB", "id": "P29401", "url": "https://www.uniprot.org/uniprotkb/P29401#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6B855", "url": "https://www.uniprot.org/uniprotkb/Q6B855" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TKT", "url": "https://www.uniprot.org/uniprotkb/Q6B855", "locus": { "chromosome": "22", "start_pos": 47730815, "end_pos": 47707266, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003758", "url": "https://www.ensembl.org/id/ENSBTAG00000003758" } ] } } ], "crossref": [ { "id": "Q6B855", "url": "https://alphafold.ebi.ac.uk/entry/Q6B855", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02012", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02012", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07033", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07033", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "445425", "url": "https://www.ncbi.nlm.nih.gov/gene/445425", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005474", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005474", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005475", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005475", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020826", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020826", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029061", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029061", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033248", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033248", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049557", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049557", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:445425", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:445425", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q6B855", "url": "https://www.orthodb.org/?gene=Q6B855", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43195", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43195", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43195:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43195:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00456", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00456", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02779", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02779", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02780", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02780", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001003906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003906", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10508", "url": "https://www.rhea-db.org/rhea/10508", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q6B855", "url": "https://www.uniprot.org/uniprotkb/Q6B855", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6B855-1", "url": "https://www.uniprot.org/uniprotkb/Q6B855-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKALDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLPESELLNLRKINSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAYTGKYFDKASYRVYCMLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWNAVIVDGHSVEELCKAFGQVKNQPTAIIAKTFKGRGITGIEDKESWHGKPLPKNMADQIIQEISGQIQSKKKILATPPEEDAPSVDITNIRMPTPPNYKVGDKIATRKAYGQALAKLGHASNRIIALDGDTKNSTFSELFKKEHPDRFIECYIAEQNMVSIAVGCATRDRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSIPMSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYKQHEDFQIGQAKVVLKNKDDQVTVIGAGVTLHEALAAADLLKREKINIRVLDPFTIKPLDKKLILDSARATKGRILTVEDHYYEGGIGEAVASAVVGEPGVTVTRLAVSQVPRSGKPAELLKMFGIDRDAIAQAVRGLVTRA", "length": 623, "header": "sp|Q6B855-1|TKT_BOVIN Isoform 1 of Transketolase OS=Bos taurus OX=9913 GN=TKT PE=2 SV=1 CANONICAL=Q6B855-1" }, "isoforms": [ { "isoform_ac": "Q6B855-1", "url": "https://www.uniprot.org/uniprotkb/Q6B855/entry#Q6B855-1", "sequence": { "sequence": 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"sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q6BBL6-1", "uniprot_ac": "Q6BBL6", "uniprot_id": "CLD4_BOVIN", "mass": { "chemical_mass": 22165.0, "monoisotopic_mass": 22165.0 }, "refseq": { "ac": "NP_001014413", "name": "claudin-4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014413" }, "gene_names": [ { "name": "CLDN4", "type": "recommended", "evidence": [ { "id": "Q6BBL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6BBL6" } ] }, { "name": "CLDN4", "type": "synonym", "evidence": [ { "id": "NP_001014413", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014413" } ] } ], "protein_names": [ { "name": "Claudin-4", "type": "recommended", "evidence": [ { "id": "Q6BBL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6BBL6/entry#names_and_taxonomy" } ] }, { "name": "claudin-4", "type": "synonym", "evidence": [ { "id": "NP_001014413", "database": "RefSeq", 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Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.", "evidence": [ { "database": "UniProtKB", "id": "Q6BBL6", "url": "https://www.uniprot.org/uniprotkb/Q6BBL6#function" }, { "database": "UniProtKB", "id": "O35054", "url": "https://www.uniprot.org/uniprotkb/O35054#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6BBL6", "url": "https://www.uniprot.org/uniprotkb/Q6BBL6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLDN4", "url": "https://www.uniprot.org/uniprotkb/Q6BBL6", "locus": { "chromosome": "25", "start_pos": 33477754, "end_pos": 33480098, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026278", "url": 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"database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:414921", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:414921", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NCPPRAD", "url": "https://omabrowser.org/oma/group/NCPPRAD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q6BBL6", "url": "https://www.orthodb.org/?gene=Q6BBL6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00822", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00822", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014413", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q6BBL6", "url": "https://www.uniprot.org/uniprotkb/Q6BBL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6BBL6-1", "url": "https://www.uniprot.org/uniprotkb/Q6BBL6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASMGLQVMGIALAVLGWLGAILSCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALIVICIILAVFGVLLSVVGGKCTNCVDDESSKAKIMIVAGVVFLLAGLLVMVPVSWTANNVIRDFYNPLVASGQKREMGASLYVGWAAAGLLILGGALLCFNCPPRNDKPYSAKYSAARSAPASNYV", "length": 209, "header": "sp|Q6BBL6-1|CLD4_BOVIN Isoform 1 of Claudin-4 OS=Bos taurus OX=9913 GN=CLDN4 PE=2 SV=1 CANONICAL=Q6BBL6-1" }, "isoforms": [ { "isoform_ac": "Q6BBL6-1", "url": "https://www.uniprot.org/uniprotkb/Q6BBL6/entry#Q6BBL6-1", "sequence": { "sequence": "MASMGLQVMGIALAVLGWLGAILSCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALIVICIILAVFGVLLSVVGGKCTNCVDDESSKAKIMIVAGVVFLLAGLLVMVPVSWTANNVIRDFYNPLVASGQKREMGASLYVGWAAAGLLILGGALLCFNCPPRNDKPYSAKYSAARSAPASNYV", "length": 209, "header": "sp|Q6BBL6-1|CLD4_BOVIN Isoform 1 of Claudin-4 OS=Bos taurus OX=9913 GN=CLDN4 PE=2 SV=1 CANONICAL=Q6BBL6-1" }, "locus": { "chromosome": "25", "start_pos": 33479214, "end_pos": 33478588, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037275.6", "url": "https://www.ensembl.org/id/ENSBTAT00000037275.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037110.4", "url": "https://www.ensembl.org/id/ENSBTAP00000037110.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 208, "end_pos": 208, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by EPHA2", "evidence": [ { "database": "UniProtKB", "id": "Q6BBL6", "url": "https://www.uniprot.org/uniprotkb/Q6BBL6" } ], "site_lbl": "Tyr208" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:414921", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:414921", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O14493-1", "protein_name": "Claudin-4", "gene_name": "CLDN4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASMGLQVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNCLEDESAKAKTMIVAGVVFLLAGLMVIVPVSWTAHNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGGLLCCNCPPRTDKPYSAKYSAARSAAASNYV", "length": 209 }, "evidence": [ { "id": "Q6BBL6", "url": "https://omabrowser.org/oma/group/Q6BBL6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q6BBL6", "url": "https://www.uniprot.org/uniprotkb/Q6BBL6" } ], "pmid": "" }, { "name": "bicellular tight junction", "id": "GO:0005923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005923", "evidence": [ { "database": "UniProtKB", "id": "Q6BBL6", "url": "https://www.uniprot.org/uniprotkb/Q6BBL6" } ], "pmid": "" }, { "name": "chloride channel complex", "id": "GO:0034707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034707", "evidence": [ { "database": "UniProtKB", "id": "Q6BBL6", "url": "https://www.uniprot.org/uniprotkb/Q6BBL6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "Q6BBL6", "url": "https://www.uniprot.org/uniprotkb/Q6BBL6" } ], "pmid": "" }, { "name": "establishment of skin barrier", "id": "GO:0061436", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061436", "evidence": [ { "database": "UniProtKB", "id": "Q6BBL6", "url": "https://www.uniprot.org/uniprotkb/Q6BBL6" } ], "pmid": "" }, { "name": "positive regulation of wound healing", "id": "GO:0090303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090303", "evidence": [ { "database": "UniProtKB", "id": "Q6BBL6", "url": "https://www.uniprot.org/uniprotkb/Q6BBL6" } ], "pmid": "" }, { "name": "regulation of cell morphogenesis", "id": "GO:0022604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022604", "evidence": [ { "database": "UniProtKB", "id": "Q6BBL6", "url": "https://www.uniprot.org/uniprotkb/Q6BBL6" } ], "pmid": "" }, { "name": "renal absorption", "id": "GO:0070293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070293", "evidence": [ { "database": "UniProtKB", "id": "Q6BBL6", "url": "https://www.uniprot.org/uniprotkb/Q6BBL6" } ], "pmid": "" }, { "name": "calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules", "id": "GO:0016338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016338", "evidence": [ { "database": "UniProtKB", "id": "Q6BBL6", "url": "https://www.uniprot.org/uniprotkb/Q6BBL6" } ], "pmid": "" }, { "name": "paracellular transport", 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"count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q6EWQ6-1", "uniprot_ac": "Q6EWQ6", "uniprot_id": "DHYS_BOVIN", "mass": { "chemical_mass": 41029.0, "monoisotopic_mass": 41029.0 }, "refseq": { "ac": "NP_001003657", "name": "deoxyhypusine synthase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003657" }, "gene_names": [ { "name": "DHPS", "type": "recommended", "evidence": [ { "id": "Q6EWQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6" } ] }, { "name": "DHPS", "type": "synonym", "evidence": [ { "id": "NP_001003657", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003657" } ] }, { "name": "DYS", "type": "synonym", "evidence": [ { "id": "NP_001003657", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003657" }, { "id": "Q6EWQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6" } ] } ], "protein_names": [ { "name": "Deoxyhypusine synthase", "type": "recommended", "evidence": [ { "id": "Q6EWQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6/entry#names_and_taxonomy" } ] }, { "name": "2.5.1.46", "type": "synonym", "evidence": [ { "id": "Q6EWQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6/entry#names_and_taxonomy" } ] }, { "name": "DHS", "type": "synonym", "evidence": [ { "id": "NP_001003657", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003657" }, { "id": "Q6EWQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6/entry#names_and_taxonomy" } ] }, { "name": "deoxyhypusine synthase", "type": "synonym", "evidence": [ { "id": "NP_001003657", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003657" } ] } ], "function": [ { "annotation": "Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.", "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ6", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6#function" }, { "database": "UniProtKB", "id": "P49366", "url": "https://www.uniprot.org/uniprotkb/P49366#function" } ] }, { "annotation": "The the deduced bovine deoxyhypusine synthase protein showed a 93% identity to the human protein.", "evidence": [ { "database": "RefSeq", "id": "NP_001003657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003657" }, { "database": "PubMed", "id": "15354351", "url": "https://glygen.org/publication/PubMed/15354351" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ6", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DHPS", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6", "locus": { "chromosome": "7", "start_pos": 12820023, "end_pos": 12816113, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006247", "url": "https://www.ensembl.org/id/ENSBTAG00000006247" } ] } } ], "crossref": [ { "id": "Q6EWQ6", "url": "https://alphafold.ebi.ac.uk/entry/Q6EWQ6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006247", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006247", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "2.5.1.46", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.5.1.46&UniProtAcc=Q6EWQ6", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "444988", "url": "https://www.ncbi.nlm.nih.gov/gene/444988", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002773", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002773", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036982", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036982", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:444988", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:444988", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HSIINAN", "url": "https://omabrowser.org/oma/group/HSIINAN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q6EWQ6", "url": "https://www.orthodb.org/?gene=Q6EWQ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11703", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11703", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11703:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11703:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01916", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01916", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-204626", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204626", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001003657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003657", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "33299", "url": "https://www.rhea-db.org/rhea/33299", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q6EWQ6", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6EWQ6-1", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGPQEREVPAAALAAVLKHSSALPFETAQVRGYDFNRGVDYRALLEAFSTTGFQATNFGRAVQQVNAMIEKKLEPLSEDEDQHADLTQSRRPLTGCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDFIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNDNYCKFEDWLMPILDQMVLEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVLSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLKLINTQAIFAKRTGMIILGGGMVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRMDAQPVKVYADASLVFPLLVAETFAQKVDAFMPEKNED", "length": 369, "header": "sp|Q6EWQ6-1|DHYS_BOVIN Isoform 1 of Deoxyhypusine synthase OS=Bos taurus OX=9913 GN=DHPS PE=2 SV=2 CANONICAL=Q6EWQ6-1" }, "isoforms": [ { "isoform_ac": "Q6EWQ6-1", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6/entry#Q6EWQ6-1", "sequence": { "sequence": "MEGPQEREVPAAALAAVLKHSSALPFETAQVRGYDFNRGVDYRALLEAFSTTGFQATNFGRAVQQVNAMIEKKLEPLSEDEDQHADLTQSRRPLTGCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDFIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNDNYCKFEDWLMPILDQMVLEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVLSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLKLINTQAIFAKRTGMIILGGGMVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRMDAQPVKVYADASLVFPLLVAETFAQKVDAFMPEKNED", "length": 369, "header": "sp|Q6EWQ6-1|DHYS_BOVIN Isoform 1 of Deoxyhypusine synthase OS=Bos taurus OX=9913 GN=DHPS PE=2 SV=2 CANONICAL=Q6EWQ6-1" }, "locus": { "chromosome": "7", "start_pos": 12819919, "end_pos": 12816451, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008200.4", "url": "https://www.ensembl.org/id/ENSBTAT00000008200.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008200.2", "url": "https://www.ensembl.org/id/ENSBTAP00000008200.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 78, "end_pos": 78, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ6", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6" } ], "site_lbl": "Ser78" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Molecular cloning of bovine eIF5A and deoxyhypusine synthase cDNA.", "journal": "DNA Seq.", "date": "2004", "authors": "Huang Jenq-Kuen, Tsai Shuhui, Huang George H, Sershon Valerie C, Alley Adrienne M, Wen Lisa", "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ6", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6" }, { "database": "RefSeq", "id": "NP_001003657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003657" } ], "reference": [ { "type": "PubMed", "id": "15354351", "url": "https://glygen.org/publication/PubMed/15354351" } ] } ], "pathway": [ { "id": "bta:444988", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:444988", "resource": "KEGG Pathway" }, { "id": "R-BTA-204626", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204626", "resource": "Reactome", "description": "Hypusine synthesis from eIF5A-lysine" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SEX8-1", "protein_name": "Deoxyhypusine synthase", "gene_name": "DHPS", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEGLPEREAPAAALAAVLKHSSALPSESAQVRGYDFNRGVDYRALLEAFGTTGFQATNFGRAVQQVNAMIEKKLEPLSQDEDQHADLTQSRRPLTGCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNDNYCKFEDWLMPILDQMVLEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVLSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKRSGMIILGGGMVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRMDAQPVKVYADASLVFPLLVAETFAQKANAFMPEKNED", "length": 369 }, "evidence": [ { "id": "Q6EWQ6", "url": "https://omabrowser.org/oma/group/Q6EWQ6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HCV7-1", "protein_name": "Deoxyhypusine synthase", "gene_name": "Dhps", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEGTPQGVAPAAALAAVLKHSSALPPESAQVQGYDFNRGVDYHALLEAFGTTGFQATNFGRAVQQVNAMIEKKLEPLALGEDHHEDLTKSRRPLTGCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLSGKELRENGINRIGNLLVPNDNYCKFEDWLMPILDQMVLEQNTEGVKWTPSKMISRLGKEINNPESVYYWAHKNHIPVLSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINMQAIFAKRSGMIILGGGMVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRMDAQPVKVYADASLVFPLLVAKTFAQKADAFTAEKNED", "length": 369 }, "evidence": [ { "id": "Q6EWQ6", "url": "https://omabrowser.org/oma/group/Q6EWQ6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P38791-1", "protein_name": "Deoxyhypusine synthase", "gene_name": "DYS1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSDINEKLPELLQDAVLKASVPIPDDFVKVQGIDYSKPEATNMRATDLIEAMKTMGFQASSVGTACEIIDSMRSWRGKHIDELDDHEKKGCFDEEGYQKTTIFMGYTSNLISSGVRETLRYLVQHKMVDAVVTSAGGVEEDLIKCLAPTYLGEFALKGKSLRDQGMNRIGNLLVPNDNYCKFEEWIVPILDKMLEEQDEYVKKHGADCLEANQDVDSPIWTPSKMIDRFGKEINDESSVLYWAHKNKIPIFCPSLTDGSIGDMLFFHTFKASPKQLRVDIVGDIRKINSMSMAAYRAGMIILGGGLIKHHIANACLMRNGADYAVYINTGQEYDGSDAGARPDEAVSWGKIKAEAKSVKLFADVTTVLPLIVAATFASGKPIKKVKN", "length": 387 }, "evidence": [ { "id": "Q6EWQ6", "url": "https://omabrowser.org/oma/group/Q6EWQ6/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P49366-1", "protein_name": "Deoxyhypusine synthase", "gene_name": "DHPS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGSLEREAPAGALAAVLKHSSTLPPESTQVRGYDFNRGVNYRALLEAFGTTGFQATNFGRAVQQVNAMIEKKLEPLSQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNENYCKFEDWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVFSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKCTGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQKMDAFMHEKNED", "length": 369 }, "evidence": [ { "id": "Q6EWQ6", "url": "https://omabrowser.org/oma/group/Q6EWQ6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q3TXU5-1", "protein_name": "Deoxyhypusine synthase", "gene_name": "Dhps", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGTPPGAAPSSALAAVLKHSSALPPESAQVQGYDFNRGVDYHALLDAYRTTGFQATNFGRAVQQVNAMIEKKLEPLAVDEDHHADLTQSRRPLTGCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRESGINRIGNLLVPNDNYCKFEDWLMPILDQMVLEQNTEGVKWTPSKMISRLGKEINNPDSVYYWAHKNHIPVLSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKRSGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRMDAQPVKVYADASLVFPLLVAETFAQKADAFRAEKNED", "length": 369 }, "evidence": [ { "id": "Q6EWQ6", "url": "https://omabrowser.org/oma/group/Q6EWQ6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54MQ7-1", "protein_name": "Probable deoxyhypusine synthase", "gene_name": "dhps", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSTNTTTTNATPELAKESVFFQSNHEDLKNRPKVRGYDFNEGVDFSKLFETYKTIGYQASAVGEAIDEINRMISWRLVDEPLKEGEDDDEERKVTRCKIFLGYTSNLVSSGVREIIRYLVQHSMVDVIVSTAGGVEEDFIKCLAPTYMGEFHLEGEKLRRKGLNRIGNLLVPNDNYCKFEDWIMPILDQMVEEQKTKGTVWTPSRVINRLGKEINHEDSIYYWAWKNDIPVYSPALTDGSIGDMMYFHSYNTPGLVLDIISDIRAINNHAVYSKKSGMIILGGGVIKHHICNANLFRNGADYSVFVNTGNEFDGSDSGARPDEAVSWGKIKLDAKPVKVYSEASIVFPILVAETFAKTFKKKSPEELKLNKRSIFD", "length": 376 }, "evidence": [ { "id": "Q6EWQ6", "url": "https://omabrowser.org/oma/group/Q6EWQ6/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6AY53-1", "protein_name": "Deoxyhypusine synthase", "gene_name": "Dhps", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEGTPSGAAPSSALAAVLKHSSALPPESAQVQGYDFNRGVDYHALLEAYGTTGFQATNFGRAVQQVNAMIEKKLEPLAVDEDHHEDLTQSRRPLTGCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNDNYCKFEDWLMPILDQMVQEQNTEGVKWTPSKMISRLGKEINNPESVYYWAHKNHIPVLSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINMQAIFAKRTGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRMDAQPVKVYADASLVFPLLVAETFAQKADAFRAEKNED", "length": 369 }, "evidence": [ { "id": "Q6EWQ6", "url": "https://omabrowser.org/oma/group/Q6EWQ6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9FI94-1", "protein_name": "Deoxyhypusine synthase", "gene_name": "DHS", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEDDRVFSSVHSTVFKESESLEGKCDKIEGYDFNQGVDYPKLMRSMLTTGFQASNLGEAIDVVNQMLDWRLADETTVAEDCSEEEKNPSFRESVKCKIFLGFTSNLVSSGVRDTIRYLVQHHMVDVIVTTTGGVEEDLIKCLAPTFKGDFSLPGAYLRSKGLNRIGNLLVPNDNYCKFEDWIIPIFDEMLKEQKEENVLWTPSKLLARLGKEINNESSYLYWAYKMNIPVFCPGLTDGSLGDMLYFHSFRTSGLIIDVVQDIRAMNGEAVHANPKKTGMIILGGGLPKHHICNANMMRNGADYAVFINTGQEFDGSDSGARPDEAVSWGKIRGSAKTVKVYCDATIAFPLLVAETFATKRDQTCESKT", "length": 368 }, "evidence": [ { "id": "Q6EWQ6", "url": "https://omabrowser.org/oma/group/Q6EWQ6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VSF4-1", "protein_name": "Probable deoxyhypusine synthase", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSTEPSVAKDAVLKRSEALAENTPQVSGYDFNEGLDYSKLFESYVNTGFQATNLGLAIREINRMLDCRDQPLEADQIDSHETDDFIRRRSKCTVFLGYTSNLVSSGLRETIRFLAEHRMIDCIVTTAGGVEEDFIKCLAPTFMGSFELSGRDLRERGINRIGNLLVPNDNYCKFEDWVMPLLDEMLEEQKSQGTIWSPSKIIHRLGERIGDPSSIYYWAAKNQIPVFCPALTDGSLGDMMYFHSFRQPGLVVDILSDLRRLNTMAVKAVNSGMIIVGGGVIKHHICNANLMRNGADYSVFINTASEFDGSDSGARPDEAISWGKIRKDATPVKVYAEASLVFPLIVGETFAKRHHCAGKELPRETNQV", "length": 368 }, "evidence": [ { "id": "Q6EWQ6", "url": "https://omabrowser.org/oma/group/Q6EWQ6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "spermidine metabolic process", "id": "GO:0008216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008216", "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ6", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6" } ], "pmid": "" }, { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ6", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "deoxyhypusine synthase activity", "id": "GO:0034038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034038", "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ6", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ6", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ6", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ6", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "33299", "name": "", "equation": "[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6EWQ6-1" ], "evidence": [ { "id": "33299", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33299" } ] }, { "id": "R-BTA-204617", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6EWQ6-1" ], "evidence": [ { "id": "R-BTA-204617", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204617" } ] }, { "id": "R-BTA-204647", "name": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-204628" ], "enzyme_list": [ "Q6EWQ6-1" ], "evidence": [ { "id": "R-BTA-204647", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204647" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-204628", "participant_name": "1,3-diaminopropane [cytosol]", "crossref": [ { "id": "ZINC000005828682", "database": "ZINC", "url": "" }, { "id": "15725", "database": "ChEBI", "url": "" }, { "id": "HMDB0000002", "database": "HMDB Metabolite", "url": "" }, { "id": "C00986", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q6EWQ6", "gene_name": "DHPS", "activity": [ { "ec_number": "2.5.1.46", "activity": "[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine.", "evidence": [ { "id": "Q6EWQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6" } ] }, { "ec_number": "2.5.1.46", "activity": "", "evidence": [ { "id": "Q6EWQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ6" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q6EWQ6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 369, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q6EWQ6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q6EWQ6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.5.1.46", "ec_name": "[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine.", "evidence": [ { "id": "2.5.1.46", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.46" }, { "id": "2.5.1.46", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.5.1.46" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 78 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"evidence": [ { "id": "NP_001003658", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003658" }, { "id": "Q6EWQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ7/entry#names_and_taxonomy" } ] }, { "name": "eIF-5A1", "type": "synonym", "evidence": [ { "id": "NP_001003658", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003658" }, { "id": "Q6EWQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ7/entry#names_and_taxonomy" } ] }, { "name": "eIF-5A", "type": "synonym", "evidence": [ { "id": "NP_001003658", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003658" }, { "id": "Q6EWQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ7/entry#names_and_taxonomy" } ] }, { "name": "eukaryotic initiation factor 5A", "type": "synonym", "evidence": [ { "id": "NP_001003658", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003658" } ] }, { "name": "eukaryotic translation initiation factor 5A-1", "type": "synonym", "evidence": [ { "id": "NP_001003658", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003658" } ] } ], "function": [ { "annotation": "The deduced bovine eIF5A protein is 100% identical to human Eif5A.", "evidence": [ { "database": "RefSeq", "id": "NP_001003658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003658" }, { "database": "PubMed", "id": "15354351", "url": "https://glygen.org/publication/PubMed/15354351" } ] }, { "annotation": "Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (By similarity). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Also regulates TNF-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival (By similarity). Is required for autophagy by assisting the ribosome in translating the ATG3 protein at a specific amino acid sequence, the 'ASP-ASP-Gly' motif, leading to the increase of the efficiency of ATG3 translation and facilitation of LC3B lipidation and autophagosome formation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ7", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ7#function" }, { "database": "UniProtKB", "id": "P63241", "url": "https://www.uniprot.org/uniprotkb/P63241#function" }, { "database": "UniProtKB", "id": "P23301", "url": "https://www.uniprot.org/uniprotkb/P23301#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ7", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF5A", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ7", "locus": { "chromosome": "19", "start_pos": 27020476, "end_pos": 27015093, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002018", "url": "https://www.ensembl.org/id/ENSBTAG00000002018" } ] } } ], "crossref": [ { "id": "Q6EWQ7", "url": "https://alphafold.ebi.ac.uk/entry/Q6EWQ7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002018", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002018", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04468", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04468", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "444990", "url": "https://www.ncbi.nlm.nih.gov/gene/444990", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008991", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008991", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014722", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014722", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019769", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019769", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020189", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020189", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048670", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048670", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:444990", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:444990", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KDDVRMP", "url": "https://omabrowser.org/oma/group/KDDVRMP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q6EWQ7", "url": "https://www.orthodb.org/?gene=Q6EWQ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11673", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11673", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01287", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01287", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21485", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21485", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-204626", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204626", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001003658", "url": 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"MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK", "length": 154, "header": "sp|Q6EWQ7-1|IF5A1_BOVIN Isoform 1 of Eukaryotic translation initiation factor 5A-1 OS=Bos taurus OX=9913 GN=EIF5A PE=2 SV=3 CANONICAL=Q6EWQ7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Molecular cloning of bovine eIF5A and deoxyhypusine synthase cDNA.", "journal": "DNA Seq.", "date": "2004", "authors": "Huang Jenq-Kuen, Tsai Shuhui, Huang George H, Sershon Valerie C, Alley Adrienne M, Wen Lisa", "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ7", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ7" }, { "database": "RefSeq", "id": "NP_001003658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003658" } ], "reference": [ { "type": "PubMed", "id": "15354351", "url": "https://glygen.org/publication/PubMed/15354351" } ] } ], "pathway": [ { "id": "bta:444990", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:444990", "resource": "KEGG Pathway" }, { "id": "R-BTA-204626", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204626", "resource": "Reactome", "description": "Hypusine synthesis from eIF5A-lysine" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MWQ9-1", "protein_name": "Eukaryotic translation initiation factor 5A", "gene_name": "Eif5a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK", "length": 154 }, "evidence": [ { "id": "Q6EWQ7", "url": "https://omabrowser.org/oma/group/Q6EWQ7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P23301-1", "protein_name": "Eukaryotic translation initiation factor 5A-1", 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"uniprot_canonical_ac": "P63242-1", "protein_name": "Eukaryotic translation initiation factor 5A-1", "gene_name": "Eif5a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK", "length": 154 }, "evidence": [ { "id": "Q6EWQ7", "url": "https://omabrowser.org/oma/group/Q6EWQ7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9GU68-1", "protein_name": "Eukaryotic translation initiation factor 5A", "gene_name": "eEF5", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAELDDQFETTDSGASTTYPMQCSALRKNGFVMLKSRPCKIVEMSTSKTGKHGHAKVHMVGIDIFSNKKYEDICPSTHNMDVPNVKREDLQLIAISDDSFLTLMTESGDLREDLKVPEGELGEQLRLDFDSGKDLLCTVLKACGEECVIAIKTNTALDK", "length": 159 }, "evidence": [ { "id": "Q6EWQ7", "url": "https://omabrowser.org/oma/group/Q6EWQ7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ7", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ7" } ], "pmid": "" }, { "name": "translation elongation factor activity", "id": "GO:0003746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003746", "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ7", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ7" } ], "pmid": "" }, { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ7", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ7", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ7" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ7", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ7" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ7", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translational elongation", "id": "GO:0006414", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006414", "evidence": [ { "database": "UniProtKB", "id": "Q6EWQ7", "url": "https://www.uniprot.org/uniprotkb/Q6EWQ7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], 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"field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q6L708-1", "uniprot_ac": "Q6L708", "uniprot_id": "CLD1_BOVIN", "mass": { "chemical_mass": 22865.0, "monoisotopic_mass": 22865.0 }, "refseq": { "ac": "NP_001001854", "name": "claudin-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001854" }, "gene_names": [ { "name": "CLDN1", "type": "recommended", "evidence": [ { "id": "Q6L708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6L708" } ] }, { "name": "CLDN1", "type": "synonym", "evidence": [ { "id": "NP_001001854", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001854" } ] } ], "protein_names": [ { "name": "Claudin-1", "type": "recommended", "evidence": [ { "id": "Q6L708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6L708/entry#names_and_taxonomy" } ] }, { "name": "claudin-1", "type": "synonym", "evidence": [ { "id": "NP_001001854", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001854" } ] } ], "function": [ { "annotation": "Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q6L708", "url": "https://www.uniprot.org/uniprotkb/Q6L708#function" } ] }, { "annotation": "Expression in the rumen epithelium.", "evidence": [ { "database": "RefSeq", "id": "NP_001001854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001854" }, { "database": "PubMed", "id": "15319221", "url": "https://glygen.org/publication/PubMed/15319221" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6L708", "url": "https://www.uniprot.org/uniprotkb/Q6L708" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLDN1", "url": "https://www.uniprot.org/uniprotkb/Q6L708", "locus": { "chromosome": "1", "start_pos": 76989396, "end_pos": 76973808, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013148", "url": "https://www.ensembl.org/id/ENSBTAG00000013148" } ] } } ], "crossref": [ { "id": "Q6L708", "url": "https://alphafold.ebi.ac.uk/entry/Q6L708", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013148", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013148", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "414922", "url": "https://www.ncbi.nlm.nih.gov/gene/414922", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003548", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003548", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004031", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004031", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:414922", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:414922", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MPQWKIS", "url": "https://omabrowser.org/oma/group/MPQWKIS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q6L708", "url": "https://www.orthodb.org/?gene=Q6L708", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00822", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00822", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001001854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001854", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q6L708", "url": "https://www.uniprot.org/uniprotkb/Q6L708", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6L708-1", "url": "https://www.uniprot.org/uniprotkb/Q6L708-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANAGLQLLGFILAFLGWIGSIVSTALPQWKVYSYASDNIVTAQAIYEGLWMSCVSQSTGQIQCKVFDSLLNLNSTLQATRALMVIGILLGLIAIFVATVGMKCMKCMEDDEAQKMRMAVFGGVIFLISGLAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFIGWAAASLCLLGGALLCCSCPRKTTSYPTPRPYPKPAPSSGKDYV", "length": 211, "header": "sp|Q6L708-1|CLD1_BOVIN Isoform 1 of Claudin-1 OS=Bos taurus OX=9913 GN=CLDN1 PE=2 SV=1 CANONICAL=Q6L708-1" }, "isoforms": [ { "isoform_ac": "Q6L708-1", "url": "https://www.uniprot.org/uniprotkb/Q6L708/entry#Q6L708-1", "sequence": { "sequence": "MANAGLQLLGFILAFLGWIGSIVSTALPQWKVYSYASDNIVTAQAIYEGLWMSCVSQSTGQIQCKVFDSLLNLNSTLQATRALMVIGILLGLIAIFVATVGMKCMKCMEDDEAQKMRMAVFGGVIFLISGLAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFIGWAAASLCLLGGALLCCSCPRKTTSYPTPRPYPKPAPSSGKDYV", "length": 211, "header": "sp|Q6L708-1|CLD1_BOVIN Isoform 1 of Claudin-1 OS=Bos taurus OX=9913 GN=CLDN1 PE=2 SV=1 CANONICAL=Q6L708-1" }, "locus": { "chromosome": "1", "start_pos": 76989030, "end_pos": 76974045, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017476.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017476.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017476.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017476.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Functional organization of the bovine rumen epithelium.", "journal": "American journal of physiology. Regulatory, integrative and comparative physiology", "date": "2005-01", "authors": "Graham C, Simmons N L", "evidence": [ { "database": "RefSeq", "id": "NP_001001854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001854" } ], "reference": [ { "type": "PubMed", "id": "15319221", "url": "https://glygen.org/publication/PubMed/15319221" } ] }, { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q6L708", "url": "https://www.uniprot.org/uniprotkb/Q6L708" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:414922", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:414922", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A1F1-1", "protein_name": "Claudin", "gene_name": "CLDN1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MANAGLQLLGFILAFLGWIGSIVSTALPQWKIYSYAGDNIVTAQAIYEGLWMSCVSQSTGQIQCKVFDSLLNLNSTLQATRALMVIGILLGLIAIFVATVGMKCMKCMEDDEVQKMRMAVIGGVIFLISGLAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLCCSCPRKTTSYPTPRPYPKPSPSSGKDYV", "length": 211 }, "evidence": [ { "id": "Q6L708", "url": "https://omabrowser.org/oma/group/Q6L708/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GT81-1", "protein_name": "Claudin", "gene_name": "Cldn1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MANAGLQLLGFILASLGWIGSIVSTALPQWKIYSYAGDNIVTAQAIYEGLWMSCVSQSTGQIQCKVFDSLLNLNSTLQATRALMVIGILLGLIAIFVSTIGMKCMKCLEDDEVQKMWMAVIGGVIFITSGLSILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLSCSCPRKTTSYPTPRPYPKPTPSSGKDYV", "length": 211 }, "evidence": [ { "id": "Q6L708", "url": "https://omabrowser.org/oma/group/Q6L708/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O88551-1", "protein_name": "Claudin-1", "gene_name": "Cldn1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MANAGLQLLGFILASLGWIGSIVSTALPQWKIYSYAGDNIVTAQAIYEGLWMSCVSQSTGQIQCKVFDSLLNLNSTLQATRALMVIGILLGLIAIFVSTIGMKCMRCLEDDEVQKMWMAVIGGIIFLISGLATLVATAWYGNRIVQEFYDPLTPINARYEFGQALFTGWAAASLCLLGGVLLSCSCPRKTTSYPTPRPYPKPTPSSGKDYV", "length": 211 }, "evidence": [ { "id": "Q6L708", "url": "https://omabrowser.org/oma/group/Q6L708/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O95832-1", "protein_name": "Claudin-1", "gene_name": "CLDN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"https://www.ensembl.org/id/ENSBTAP00000053147.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:3283879", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:3283879", "resource": "KEGG Pathway" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-5628897", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5628897", "resource": "Reactome", "description": "TP53 Regulates Metabolic Genes" }, { "id": "R-BTA-611105", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-611105", "resource": "Reactome", "description": "Respiratory electron transport" }, { "id": "R-BTA-9707564", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9707564", "resource": "Reactome", "description": "Cytoprotection by HMOX1" }, { "id": "R-BTA-9837999", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9837999", "resource": "Reactome", "description": "Mitochondrial protein degradation" }, { "id": "R-BTA-9864848", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "resource": "Reactome", "description": "Complex IV assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "O79876-1", "protein_name": "Cytochrome c oxidase subunit 1", "gene_name": "MT-CO1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFVNRWLYSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLNQAWAKIHFVIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTAWNTISSMGSFISLTAVMLMIFIIWEAFASKREVSAVELTSTNLEWLHGCPPPYHTFEEPTYINLK", "length": 514 }, "evidence": [ { "id": "Q6QTG9", "url": "https://omabrowser.org/oma/group/Q6QTG9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P00395-1", "protein_name": "Cytochrome c oxidase subunit 1", "gene_name": "MT-CO1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS", "length": 513 }, "evidence": [ { "id": "Q6QTG9", "url": "https://omabrowser.org/oma/group/Q6QTG9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P00397-1", "protein_name": "Cytochrome c oxidase subunit 1", "gene_name": "Mtco1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSILIRAELGQPGALLGDDQIYNVIVTAHAFVMIFFMVMPMMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHVVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGLDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTVGGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFVHWFPLFSGFTLDDTWAKAHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTTWNTVSSMGSFISLTAVLIMIFMIWEAFASKREVMSVSYASTNLEWLHGCPPPYHTFEEPTYVKVK", "length": 514 }, "evidence": [ { "id": "Q6QTG9", "url": "https://omabrowser.org/oma/group/Q6QTG9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P00399-1", "protein_name": "Cytochrome c oxidase subunit 1", "gene_name": "mt:CoI", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "SRQWLFSTNHKDIGTLYFIFGAWAGMVGTSLSILIRAELGHPGALIGDDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPALSLLLVSSMVENGAGTGWTVYPPLSAGIAHGGASVDLAIFSLHLAGISSILGAVNFITTVINMRSTGISLDRMPLFVWSVVITALLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIISQESGKKETFGSLGMIYAMLAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATLHGTQLSYSPAILWALGFVFLFTVGGLTGVVLANSSVDIILHDTYYVVAHFHYVLSMGAVFAIMAGFIHWYPLFTGLTLNNKWLKSHFIIMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTTWNIVSTIGSTISLLGILFFFFIIWESLVSQRQVIYPIQLNSSIEWYQNTPPAEHSYSELPLLTN", "length": 511 }, "evidence": [ { "id": "Q6QTG9", "url": "https://omabrowser.org/oma/group/Q6QTG9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P00401-1", "protein_name": "Cytochrome c oxidase subunit 1", "gene_name": "COX1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MVQRWLYSTNAKDIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLHGNSQLFNVLVVGHAVLMIFFLVMPALIGGFGNYLLPLMIGATDTAFPRINNIAFWVLPMGLVCLVTSTLVESGAGTGWTVYPPLSSIQAHSGPSVDLAIFALHLTSISSLLGAINFIVTTLNMRTNGMTMHKLPLFVWSIFITAFLLLLSLPVLSAGITMLLLDRNFNTSFFEVSGGGDPILYEHLFWFFGHPEVYILIIPGFGIISHVVSTYSKKPVFGEISMVYAMASIGLLGFLVWSHHMYIVGLDADTRAYFTSATMIIAIPTGIKIFSWLATIHGGSIRLATPMLYAIAFLFLFTMGGLTGVALANASLDVAFHDTYYVVGHFHYVLSMGAIFSLFAGYYYWSPQILGLNYNEKLAQIQFWLIFIGANVIFFPMHFLGINGMPRRIPDYPDAFAGWNYVASIGSFIATLSLFLFIYILYDQLVNGLNNKVNNKSVIYNKAPDFVESNTIFNLNTVKSSSIEFLLTSPPAVHSFNTPAVQS", "length": 534 }, "evidence": [ { "id": "Q6QTG9", "url": "https://omabrowser.org/oma/group/Q6QTG9/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P05503-1", "protein_name": "Cytochrome c oxidase subunit 1", "gene_name": "Mt-co1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLVNRWLFSTNHKDIGTLYLLFGAWAGMVGTALSILIRAELGQPGALLGDDQIYNVIVTAHAFVMIFFMVMPMMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHVVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGLDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTVGGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFVHWFPLFSGYTLNDTWAKAHFAIMFVGVNMTFFPQHFLGLAGMPRRYSDYPDAYTTWNTVSSMGSFISLTAVLVMIFMIWEAFASKREVLSISYSSTNLEWLHGCPPPYHTFEEPSYVKVK", "length": 514 }, "evidence": [ { "id": "Q6QTG9", "url": "https://omabrowser.org/oma/group/Q6QTG9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P60620-1", "protein_name": "Cytochrome c oxidase subunit 1", "gene_name": "COX1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MKNLVRWLFSTNHKDIGTLYFIFGAIAGVMGTCFSVLIRMELARPGDQILGGNHQLYNVLITAHAFLMIFFMVMPAMIGGFGNWFVPILIGAPDMAFPRLNNISFWLLPPSLLLLLSSALVEVGSGTGWTVYPPLSGITSHSGGAVDLAIFSLHLSGVSSILGSINFITTIFNMRGPGMTMHRLPLFVWSVLVTAFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHIVSTFSGKPVFGYLGMVYAMISIGVLGFLVWAHHMFTVGLDVDTRAYFTAATMIIAVPTGIKIFSWIATMWGGSIQYKTPMLFAVGFIFLFTIGGLTGIVLANSGLDIALHDTYYVVAHFHYVLSMGAVFALFAGFYYWVGKIFGRTYPETLGQIHFWITFFGVNLTFFPMHFLGLSGMPRRIPDYPDAYAGWNALSSFGSYISVVGICCFFVVVTITLSSGNNKRCAPSPWALELNSTTLEWMVQSPPAFHTFGELPAIKETKSYVK", "length": 527 }, "evidence": [ { "id": "Q6QTG9", "url": "https://omabrowser.org/oma/group/Q6QTG9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q76L16-1", "protein_name": "Cytochrome c oxidase subunit 1", "gene_name": "COX1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTFINRWLFSTNHKDIGTLYLIFGTWAGMAGTALSLLIRAELGQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSTVEAGAGTGWTVYPPLAGNLAHAGASVDLAIFSLHLAGVSSILGAINFITTIINMKPPALSQYQTPLFVWSVLITAILLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHVVAYYAGKKEPFGYMGMVWAMLSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGIKVFSWLATLHGGTIKWDPPMLWALGFIFLFTIGGLTGIVLANSSLDIALHDTYYVVAHFHYVLSMGAVFAILAGFTHWFPLFTGFTLHPSWTKAHFGVMFTGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNTLSSIGSLISMTAVIMLMFIVWEAFSAKRKVLQPELTATNIEWIHGCPPPYHTFEEPAFVQVQE", "length": 516 }, "evidence": [ { "id": "Q6QTG9", "url": "https://omabrowser.org/oma/group/Q6QTG9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9MIY8-1", "protein_name": "Cytochrome c oxidase subunit 1", "gene_name": "mt-co1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTITRWFFSTNHKDIGTLYLVFGAWAGMVGTALSLLIRAELSQPGALLGDDQIYNVIVTAHAFVMIFFMVMPILIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTTINMKPPTISQYQTPLFVWAVLVTAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHVVAYYAGKKEPFGYMGMVWAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGAIKWETPMLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFVHWFPLFTGYTLNSVWTKIHFGVMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYALWNTVSSIGSLISLVAVIMFLFILWEAFTAKREVLSVELTATNVEWLHGCPPPYHTFEEPAFVQIQSN", "length": 516 }, "evidence": [ { "id": "Q6QTG9", "url": "https://omabrowser.org/oma/group/Q6QTG9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q6QTG9", "url": "https://www.uniprot.org/uniprotkb/Q6QTG9" } ], "pmid": "" }, { "name": "respiratory chain complex IV", "id": "GO:0045277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045277", "evidence": [ { "database": "UniProtKB", "id": "Q6QTG9", "url": "https://www.uniprot.org/uniprotkb/Q6QTG9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q6QTG9", "url": "https://www.uniprot.org/uniprotkb/Q6QTG9" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "Q6QTG9", "url": "https://www.uniprot.org/uniprotkb/Q6QTG9" } ], "pmid": "" }, { "name": "cytochrome-c oxidase activity", "id": "GO:0004129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004129", "evidence": [ { "database": "UniProtKB", "id": "Q6QTG9", "url": "https://www.uniprot.org/uniprotkb/Q6QTG9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "oxidative phosphorylation", "id": "GO:0006119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006119", "evidence": [ { "database": "UniProtKB", "id": "Q6QTG9", "url": "https://www.uniprot.org/uniprotkb/Q6QTG9" } ], "pmid": "" }, { "name": "respiratory electron transport chain", "id": "GO:0022904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022904", "evidence": [ { "database": "UniProtKB", "id": "Q6QTG9", "url": "https://www.uniprot.org/uniprotkb/Q6QTG9" } ], "pmid": "" }, { "name": "aerobic respiration", "id": "GO:0009060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009060", "evidence": [ { "database": "UniProtKB", "id": "Q6QTG9", "url": "https://www.uniprot.org/uniprotkb/Q6QTG9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 216, "end_pos": 218, "annotation": "n_glycosylation_sequon" }, { "start_pos": 360, "end_pos": 362, "annotation": "n_glycosylation_sequon" }, { "start_pos": 406, "end_pos": 408, "annotation": "n_glycosylation_sequon" }, { "start_pos": 422, "end_pos": 424, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11436", "name": "", "equation": "4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00396-1", "P00415-1", "P68530-1", "Q6QTG9-1" ], "evidence": [ { "id": "11436", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11436" } ] }, { "id": "R-BTA-163214", "name": "Electron transfer from reduced cytochrome c to molecular oxygen", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix", "input_participant_list": [ "R-BTA-352609" ], "output_participant_list": [], "enzyme_list": [ "P68530-1", "Q6QTG9-1" ], "evidence": [ { "id": "R-BTA-163214", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163214" } ] }, { "id": "R-BTA-9709406", "name": "CO binds to Cytochrome c oxidase", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P68530-1", "Q6QTG9-1" ], "evidence": [ { "id": "R-BTA-9709406", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9709406" } ] }, { "id": "R-BTA-9838627", "name": "AFG3L2 binds mitochondrial inner membrane proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KJI7-1", "Q6QTG9-1" ], "evidence": [ { "id": "R-BTA-9838627", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9838627" } ] }, { "id": "R-BTA-9839113", "name": "AFG3L2 degrades mitochondrial inner membrane proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KJI7-1", "Q6QTG9-1" ], "evidence": [ { "id": "R-BTA-9839113", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9839113" } ] }, { "id": "R-BTA-9865350", "name": "Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6QTG9-1" ], "evidence": [ { "id": "R-BTA-9865350", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9865350" } ] }, { "id": "R-BTA-9865412", "name": "TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane, mitochondrial intermembrane space", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6QTG9-1" ], "evidence": [ { "id": "R-BTA-9865412", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9865412" } ] }, { "id": "R-BTA-9865449", "name": "Metallochaperone inserts Cu2+ into MT-CO1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08DG6-1", "Q6QTG9-1" ], "evidence": [ { "id": "R-BTA-9865449", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9865449" } ] }, { "id": "R-BTA-9865579", "name": "MT-CO1 and MT-CO2 complexes associate, installing heme moieties", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [ "R-BTA-164306" ], "output_participant_list": [ "R-BTA-9865416" ], "enzyme_list": [ "P68530-1", "Q08DG6-1", "Q6QTG9-1" ], "evidence": [ { "id": "R-BTA-9865579", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9865579" } ] }, { "id": "R-BTA-9865663", "name": "MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P68530-1", "Q6QTG9-1" ], "evidence": [ { "id": "R-BTA-9865663", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9865663" } ] }, { "id": "R-BTA-9937394", "name": "55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P03924-1", "Q3T116-1", "Q6QTG9-1" ], "evidence": [ { "id": "R-BTA-9937394", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937394" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-164306", "participant_name": "COX7C [mitochondrial inner membrane]", "crossref": [ { "id": "P00430", "database": "UniProt", "url": "" }, { "id": "5ZCO", "database": "PDB", "url": "" }, { "id": "9M56", "database": "PDB", "url": "" }, { "id": "2EIM", "database": "PDB", "url": "" }, { "id": "8D4T", "database": "PDB", "url": "" }, { "id": "3AG4", "database": "PDB", "url": "" }, { "id": "7XMB", "database": "PDB", "url": "" }, { "id": "7COH", "database": "PDB", "url": "" }, { "id": "3WG7", "database": "PDB", "url": "" }, { "id": "1OCO", "database": "PDB", "url": "" }, { 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Essential for the catalytic activity and assembly of complex I.", "evidence": [ { "database": "UniProtKB", "id": "Q6QTH0", "url": "https://www.uniprot.org/uniprotkb/Q6QTH0#function" }, { "database": "UniProtKB", "id": "ARBA00024313", "url": "https://www.uniprot.org/uniprotkb/ARBA00024313#function" }, { "database": "UniProtKB", "id": "RU003403", "url": "https://www.uniprot.org/uniprotkb/RU003403#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6QTH0", "url": "https://www.uniprot.org/uniprotkb/Q6QTH0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ND2", "url": "https://www.uniprot.org/uniprotkb/Q6QTH0", "locus": {} } ], "crossref": [ { "id": "ENSBTAG00000043571", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000043571", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "3283878", "url": "https://www.ncbi.nlm.nih.gov/gene/3283878", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001750", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001750", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003917", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003917", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010933", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010933", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050175", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050175", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:3283878", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:3283878", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HFWVPEV", "url": "https://omabrowser.org/oma/group/HFWVPEV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q6QTH0", "url": "https://www.orthodb.org/?gene=Q6QTH0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46552", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46552", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46552:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46552:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00361", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00361", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06444", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06444", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-611105", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-611105", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6799198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "YP_209206", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209206", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29091", "url": "https://www.rhea-db.org/rhea/29091", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q6QTH0", "url": "https://www.uniprot.org/uniprotkb/Q6QTH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6QTH0-1", "url": "https://www.uniprot.org/uniprotkb/Q6QTH0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNPIIFIIILLTIMLGTIIVMISSHWLLVWIGFEMNMLAIIPIMMKNHNPRATEASTKYFLTQSTASMLLMMAVIINVMFSGQWTVMKLFSPMASMLMTMALAMKLGMAPFHFWVPEVTQGIPLSSGLILLTWQKLAPMSVLYQIFPSINLNLILTLSVLSILIGGWGGLNQTQLRKIMAYSSIAHMGWMTAVLPYNPTMTLLNLIIYIIMTSTMFTMFMANSTTTTLSLSHTWNKTPIMTVLILATLLSMGGLPPLSGFMPKWMIIQEMTKNNSIILPTFMAITALLNLYFYMRLTYSTTLTMFPSTNNMKMKWQFPLMKKMTFLPTMVVLSTMMLPLTPMLSVLE", "length": 347, "header": "tr|Q6QTH0-1|Q6QTH0_BOVIN Isoform 1 of NADH-ubiquinone oxidoreductase chain 2 OS=Bos taurus OX=9913 GN=ND2 PE=3 SV=1 CANONICAL=Q6QTH0-1" }, "isoforms": [ { "isoform_ac": "Q6QTH0-1", "url": "https://www.uniprot.org/uniprotkb/Q6QTH0/entry#Q6QTH0-1", "sequence": { "sequence": "MNPIIFIIILLTIMLGTIIVMISSHWLLVWIGFEMNMLAIIPIMMKNHNPRATEASTKYFLTQSTASMLLMMAVIINVMFSGQWTVMKLFSPMASMLMTMALAMKLGMAPFHFWVPEVTQGIPLSSGLILLTWQKLAPMSVLYQIFPSINLNLILTLSVLSILIGGWGGLNQTQLRKIMAYSSIAHMGWMTAVLPYNPTMTLLNLIIYIIMTSTMFTMFMANSTTTTLSLSHTWNKTPIMTVLILATLLSMGGLPPLSGFMPKWMIIQEMTKNNSIILPTFMAITALLNLYFYMRLTYSTTLTMFPSTNNMKMKWQFPLMKKMTFLPTMVVLSTMMLPLTPMLSVLE", "length": 347, "header": "tr|Q6QTH0-1|Q6QTH0_BOVIN Isoform 1 of NADH-ubiquinone oxidoreductase chain 2 OS=Bos taurus OX=9913 GN=ND2 PE=3 SV=1 CANONICAL=Q6QTH0-1" }, "locus": { "chromosome": "Mitochondrion", "start_pos": 5306, "end_pos": 4266, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000060548.1", "url": "https://www.ensembl.org/id/ENSBTAT00000060548.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053160.1", "url": "https://www.ensembl.org/id/ENSBTAP00000053160.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:3283878", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:3283878", "resource": "KEGG Pathway" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-611105", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-611105", "resource": "Reactome", "description": "Respiratory electron transport" }, { "id": "R-BTA-6799198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "resource": "Reactome", "description": "Complex I biogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "O79875-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 2", "gene_name": "MT-ND2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNPIIYTTLIMTVMSGTMLVMISSHWLLIWIGFEMNLLAMIPVLMKNFNPRATEAATKYFLTQATASMMLMMAIIINLLYSGQWTITKMFNPVAMTMMTMALAMKLGLSPFHFWVPEVTQGISLQAGLLLLTWQKLAPLSVLCQISQSINPNLMLTMAMLSILIGGWGGLNQTQLRKIMAYSSIAHMGWMTAVLPYNTTMTILNLLIYITMTLAMFMLLIHSSATTTLSLSHTWNKMPVITSLMMVTLLSMGGLPPLSGFMPKWMIIQEMTKNESIIMPTLMAMTALLNLYFYMRLAYSSSLTMFPSTNNMKMKWQFEHTKQMKLLPTMIVLSTLVLPMTPALSSLN", "length": 347 }, "evidence": [ { "id": "Q6QTH0", "url": "https://omabrowser.org/oma/group/Q6QTH0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P03891-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 2", "gene_name": "MT-ND2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSILSIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTTLLLPISPFMLMIL", "length": 347 }, "evidence": [ { "id": "Q6QTH0", "url": "https://omabrowser.org/oma/group/Q6QTH0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P03893-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 2", "gene_name": "mt-Nd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNPITLAIIYFTIFLGPVITMSSTNLMLMWVGLEFSLLAIIPMLINKKNPRSTEAATKYFVTQATASMIILLAIVLNYKQLGTWMFQQQTNGLILNMTLMALSMKLGLAPFHFWLPEVTQGIPLHMGLILLTWQKIAPLSILIQIYPLLNSTIILMLAITSIFMGAWGGLNQTQMRKIMAYSSIAHMGWMLAILPYNPSLTLLNLMIYIILTAPMFMALMLNNSMTINSISLLWNKTPAMLTMISLMLLSLGGLPPLTGFLPKWIIITELMKNNCLIMATLMAMMALLNLFFYTRLIYSTSLTMFPTNNNSKMMTHQTKTKPNLMFSTLAIMSTMTLPLAPQLIT", "length": 345 }, "evidence": [ { "id": "Q6QTH0", "url": "https://omabrowser.org/oma/group/Q6QTH0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P03896-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 2", "gene_name": "mt:ND2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFNNSSKILFITIMIIGTLITVTSNSWLGAWMGLEINLLSFIPLLSDNNNLMSTEASLKYFLTQVLASTVLLFSSILLMLKNNMNNEINESFTSMIIMSALLLKSGAAPFHFWFPNMMEGLTWMNALMLMTWQKIAPLMLISYLNIKYLLLISVILSVIIGAIGGLNQTSLRKLMAFSSINHLGWMLSSLMISESIWLIYFFFYSFLSFVLTFMFNIFKLFHLNQLFSWFVNSKILKFTLFMNFLSLGGLPPFLGFLPKWLVIQQLTLCNQYFMLTLMMMSTLITLFFYLRICYSAFMMNYFENNWIMKMNMNSINYNMYMIMTFFSIFGLFLISLFYFMF", "length": 341 }, "evidence": [ { "id": "Q6QTH0", "url": "https://omabrowser.org/oma/group/Q6QTH0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P11662-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 2", "gene_name": "Mt-nd2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNPITLIIIYFTILMGPVITMSSSNLLLMWVGLEMSLLAIIPLLANKKSPRSTEAATKYFLTQATASMIILLVIILNYKQSGMWTLQQQTNNMLLNMMLISLAMKLGLAPFHYWLPEVTQGIPLHIGLILLTWQKIAPLSILYQFYQLLNPTITTILAISSVFVGAWGGLNQTQTRKIMAYSSIAHMGWMTAILPYNPNLTLLNLTIYILLTVPMFITLMTNSATTINTLSLAWNKTPMILTMTSIILLSLGGLPPLTGFLPKWAIISELLKNNCSTLSTLMAIMALLSLFFYTRLIYSMSLTMFPTNNNSKMISHHHQNPKHNFILPTLTVLSTLTLPLSSQLIT", "length": 346 }, "evidence": [ { "id": "Q6QTH0", "url": "https://omabrowser.org/oma/group/Q6QTH0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q85BF7-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 2", "gene_name": "ND2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNPHAKLICTVSLIMGTSITISSNHWILAWTGLEINTLAIIPLISKSHHPRAIEATIKYFLTQSTASALILFSSMTNAWSTGQWDITQLNHPTSCLMLTMAIAIKLGLVPFHFWFPEVLQGSSLITALLLSTLMKLPPITLLLLTSQSLNTTLLTLLAISSTLIGGWMGLNQTQTRKILAFSSISHLGWMIMIISYNPQLTILTFILYTIMTSTVFLSLAQIKVLKLSTMLISWTKTPMLNATVMLTLLSLAGLPPLTGFMPKWLIIQELTKQEMTPMATIITMLSLLSLFFYLRLAYHSTITLPPNSSNHMKLWRTNKTLNTPTAILTALSTTLLPLSPLIITML", "length": 346 }, "evidence": [ { "id": "Q6QTH0", "url": "https://omabrowser.org/oma/group/Q6QTH0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9MIY9-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 2", "gene_name": "mt-nd2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNPYVLMILMSSLGLGTTLTFSSSHWILAWMGLEINTLAIVPLMAQQHHPRAVEATTKYFLIQAAAAAMILFTSTTNAWISGQWDVTGMPGPATSTAMMFALALKIGLAPMHFWLPEVLQGLDLLTGLILSTWQKLAPMALIIQTTQTTDPLILTSLGIASSLIGGWSGLNQTQLRKILAYSSIAHMGWMIIVIQYAPQLTLIALGTYIFMTSAAFLTLKVLSATKINTLTTTWPKSPILAAIATLVMLSLGGLPPLTGFMPKWLILQELTKQDLPATATIMALTALLSLFFYLRLCHAMTLTTSPNTINSAPHWRVQTTQNSLPLTISVTVTMGLLPLTPAILMLTT", "length": 348 }, "evidence": [ { "id": "Q6QTH0", "url": "https://omabrowser.org/oma/group/Q6QTH0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q6QTH0", "url": "https://www.uniprot.org/uniprotkb/Q6QTH0" } ], "pmid": "" }, { "name": "respiratory chain complex I", "id": "GO:0045271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045271", "evidence": [ { "database": "UniProtKB", "id": "Q6QTH0", "url": "https://www.uniprot.org/uniprotkb/Q6QTH0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "Q6QTH0", "url": "https://www.uniprot.org/uniprotkb/Q6QTH0" } ], "pmid": "" }, { "name": "mitochondrial electron transport, NADH to ubiquinone", "id": "GO:0006120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006120", "evidence": [ { "database": "UniProtKB", "id": "Q6QTH0", "url": "https://www.uniprot.org/uniprotkb/Q6QTH0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "NADH dehydrogenase (ubiquinone) activity", "id": "GO:0008137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008137", "evidence": [ { "database": "UniProtKB", "id": "Q6QTH0", "url": "https://www.uniprot.org/uniprotkb/Q6QTH0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" }, { "start_pos": 235, "end_pos": 237, "annotation": "n_glycosylation_sequon" }, { "start_pos": 273, "end_pos": 275, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29091", "name": "", "equation": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6QTH1-1", "Q85BD6-1", "A0AAA9SEY3-1", "A0AAA9TZL3-1", "P03920-1", "P03887-1", "P03892-1", "P03898-1", "P03902-1", "P03910-1", "P03924-1", "P04394-1", "P15690-1", "P17694-1", "P23709-1", "P25708-1", "P42026-1", "P42028-1", "Q6QTH0-1" ], "evidence": [ { "id": "29091", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29091" } ] }, { "id": "R-BTA-163217", "name": "Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P15690-1", "P17694-1", "P03898-1", "P03910-1", "P03924-1", "P42028-1", "P04394-1", "Q6QTH1-1", "Q85BD6-1", "P25708-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-163217", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163217" } ] }, { "id": "R-BTA-5419271", "name": "55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane, mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P03898-1", "P03910-1", "P03902-1", "P68530-1", "Q6QTH1-1", "Q85BD6-1", "Q3T116-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-5419271", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419271" } ] }, { "id": "R-BTA-6799179", "name": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P15690-1", "P17694-1", "P03898-1", "P03910-1", "P03924-1", "P42028-1", "P04394-1", "Q6QTH1-1", "Q85BD6-1", "F1MJQ5-1", "P25708-1", "A0A3Q1MP25-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-6799179", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799179" } ] }, { "id": "R-BTA-6799196", "name": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P15690-1", "P17694-1", "P03898-1", "P03910-1", "P03924-1", "P42028-1", "P04394-1", "Q6QTH1-1", "Q85BD6-1", "F1MJQ5-1", "P25708-1", "A0A3Q1MP25-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-6799196", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799196" } ] }, { "id": "R-BTA-6799197", "name": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P17694-1", "P03898-1", "P03910-1", "P03924-1", "P42028-1", "Q6QTH1-1", "Q85BD6-1", "F1MJQ5-1", "A0A3Q1MP25-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-6799197", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799197" } ] }, { "id": "R-BTA-6799199", "name": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P03898-1", "P03924-1", "A0A3Q1MP25-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-6799199", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799199" } ] }, { "id": "R-BTA-6799202", "name": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P17694-1", "P03898-1", "P03924-1", "P42028-1", "Q6QTH1-1", "F1MJQ5-1", "A0A3Q1MP25-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-6799202", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799202" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MP25", "gene_name": "ACAD9", "activity": [ { "ec_number": "1.3.8.7", "activity": "a medium-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "A0A3Q1MP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP25" } ] }, { "ec_number": "1.3.8.8", "activity": "a long-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "A0A3Q1MP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP25" } ] }, { "ec_number": "1.3.8.7", "activity": "", "evidence": [ { "id": "A0A3Q1MP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP25" } ] }, { "ec_number": "1.3.8.8", "activity": "", "evidence": [ { "id": "A0A3Q1MP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP25" } ] } ] }, { "uniprot_ac": "A0AAA9SEY3", "gene_name": "", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "A0AAA9SEY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "A0AAA9SEY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY3" } ] } ] }, { "uniprot_ac": "A0AAA9TZL3", "gene_name": "NDUFV2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "A0AAA9TZL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZL3" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "A0AAA9TZL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZL3" } ] } ] }, { "uniprot_ac": "F1MJQ5", "gene_name": "NDUFAF7", "activity": [ { "ec_number": "2.1.1.320", "activity": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+).", "evidence": [ { "id": "F1MJQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5" } ] }, { "ec_number": "2.1.1.320", "activity": "", "evidence": [ { "id": "F1MJQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5" } ] } ] }, { "uniprot_ac": "P03887", "gene_name": "MT-ND1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03887" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03887" } ] } ] }, { "uniprot_ac": "P03892", "gene_name": "MT-ND2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03892" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03892" } ] } ] }, { "uniprot_ac": "P03898", "gene_name": "MT-ND3", 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Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections. By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis.", "evidence": [ { "database": "UniProtKB", "id": "Q6QUN5", "url": "https://www.uniprot.org/uniprotkb/Q6QUN5#function" }, { "database": "UniProtKB", "id": "Q9NP99", "url": "https://www.uniprot.org/uniprotkb/Q9NP99#function" } ] }, { "annotation": "Molecular cloning of bovine TREM-1 extends the repertoire of bovine pattern recognition receptors and provides information important for investigating their role in bovine innate immunity.", "evidence": [ { "database": "RefSeq", "id": "NP_996853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996853" }, { "database": "PubMed", "id": "15451618", "url": "https://glygen.org/publication/PubMed/15451618" } ] } ], "disease": [], "snv": [], 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"InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:404547", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404547", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q6QUN5", "url": "https://www.orthodb.org/?gene=Q6QUN5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19357", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19357", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19357:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19357:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_996853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996853", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q6QUN5", "url": "https://www.uniprot.org/uniprotkb/Q6QUN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6QUN5-1", "url": "https://www.uniprot.org/uniprotkb/Q6QUN5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRKAGVWGLLWMLFIEEIQAAAEVFEEKCTLAEGQTLKVSCPTNTNIYSNSQKAWQRLKDNGEVQTLAITEGSSQVRVGKYFLEDIPSEGMLQIQMANLQVEDSGLYRCVILGPSDPIILFHPVRLVVTKNSLGTPASDEYPCQVSVQNPTPLPVTTKLRPRPRPRPKPVTQPIPTSADRLSSPGFTVTPTNVTHVNRAPGISIIIPAACGLLSKTLVFIGLFAVTHRSFAS", "length": 232, "header": "sp|Q6QUN5-1|TREM1_BOVIN Isoform 1 of Triggering receptor expressed on myeloid cells 1 OS=Bos taurus OX=9913 GN=TREM1 PE=2 SV=1 CANONICAL=Q6QUN5-1" }, "isoforms": [ { "isoform_ac": "Q6QUN5-1", "url": "https://www.uniprot.org/uniprotkb/Q6QUN5/entry#Q6QUN5-1", "sequence": { "sequence": "MRKAGVWGLLWMLFIEEIQAAAEVFEEKCTLAEGQTLKVSCPTNTNIYSNSQKAWQRLKDNGEVQTLAITEGSSQVRVGKYFLEDIPSEGMLQIQMANLQVEDSGLYRCVILGPSDPIILFHPVRLVVTKNSLGTPASDEYPCQVSVQNPTPLPVTTKLRPRPRPRPKPVTQPIPTSADRLSSPGFTVTPTNVTHVNRAPGISIIIPAACGLLSKTLVFIGLFAVTHRSFAS", "length": 232, "header": "sp|Q6QUN5-1|TREM1_BOVIN Isoform 1 of Triggering receptor expressed on myeloid cells 1 OS=Bos taurus OX=9913 GN=TREM1 PE=2 SV=1 CANONICAL=Q6QUN5-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 192, "start_aa": "Asn", "end_pos": 192, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn192", "evidence": [ { "id": "Q6QUN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QUN5#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of bovine cDNA encoding triggering receptor expressed on myeloid cells 1 (TREM-1).", "journal": "Vet. Immunol. Immunopathol.", "date": "2004", "authors": "Ramanathan Balaji, Minton J Ernest, Ross Christopher R, Blecha Frank", "evidence": [ { "database": "UniProtKB", "id": "Q6QUN5", "url": "https://www.uniprot.org/uniprotkb/Q6QUN5" }, { "database": "RefSeq", "id": "NP_996853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996853" } ], "reference": [ { "type": "PubMed", "id": "15451618", "url": "https://glygen.org/publication/PubMed/15451618" } ] } ], "pathway": [ { "id": "bta:404547", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404547", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "neutrophil-mediated killing of gram-negative bacterium", "id": "GO:0070945", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070945", "evidence": [ { "database": "UniProtKB", "id": "Q6QUN5", "url": "https://www.uniprot.org/uniprotkb/Q6QUN5" } ], "pmid": "" }, { "name": "innate immune 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"https://data.glygen.org/ln2downloads/pdb/current/AF-Q6QUN5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q6QUN5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 192 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 192, "end_pos": 194 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, 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"count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q6RXL1-1", "uniprot_ac": "Q6RXL1", "uniprot_id": "SFTPA_BOVIN", "mass": { "chemical_mass": 26381.0, "monoisotopic_mass": 26381.0 }, "refseq": { "ac": "NP_001071306", "name": "pulmonary surfactant-associated protein A precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071306" }, "gene_names": [ { "name": "SFTPA1", "type": "recommended", "evidence": [ { "id": "Q6RXL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1" } ] }, { "name": "PSAP", "type": "synonym", "evidence": [ { "id": "NP_001071306", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071306" } ] }, { "name": "PSP-A", "type": "synonym", "evidence": [ { "id": "NP_001071306", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071306" } ] }, { "name": "SFTPA1B", "type": "synonym", "evidence": [ { "id": "NP_001071306", 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"NP_001071306", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071306" } ] } ], "function": [ { "annotation": "Gene encoding bovine surfactant protein A maps to the same locus on chromosome 28 as other collectins", "evidence": [ { "database": "RefSeq", "id": "NP_001071306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071306" }, { "database": "PubMed", "id": "15222309", "url": "https://glygen.org/publication/PubMed/15222309" } ] }, { "annotation": "In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.", "evidence": [ { "database": "UniProtKB", "id": "Q6RXL1", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1#function" }, { "database": "UniProtKB", "id": "P35242", "url": "https://www.uniprot.org/uniprotkb/P35242#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6RXL1", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SFTPA1", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1", "locus": { "chromosome": "28", "start_pos": 35645845, "end_pos": 35651824, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023032", "url": "https://www.ensembl.org/id/ENSBTAG00000023032" } ] } } ], "crossref": [ { "id": "Q6RXL1", "url": "https://alphafold.ebi.ac.uk/entry/Q6RXL1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03591", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03591", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "407213", "url": "https://www.ncbi.nlm.nih.gov/gene/407213", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051077", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051077", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:407213", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:407213", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q6RXL1", "url": "https://www.orthodb.org/?gene=Q6RXL1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24024", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24024", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24024:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24024:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00059", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00059", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071306", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q6RXL1", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6RXL1-1", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLCSLTLTLLWMVASGLECDVKEVCLGSPGIPGTPGSHGLPGRDGRDGIKGDPGPPGPMGPPGGMPGLPGRDGMTGAPGLPGERGEKGEPGERGPPGFPAYLDEELQGTLHEIRHQVLQSQGVLRLQGSVLAVGEKVFSTNGQSVNFDAIKELCARVGGHIAAPRSPEENEAIVSIVKKYNTYAYLGLVEGPTAGDFYYLDGAPVNYTNWYPGEPRGRGKEKCVEIYTDGQWNDKNCLQYRLAICEF", "length": 248, "header": "sp|Q6RXL1-1|SFTPA_BOVIN Isoform 1 of Pulmonary surfactant-associated protein A OS=Bos taurus OX=9913 GN=SFTPA1 PE=2 SV=2 CANONICAL=Q6RXL1-1" }, "isoforms": [ { "isoform_ac": "Q6RXL1-1", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1/entry#Q6RXL1-1", "sequence": { "sequence": "MLLCSLTLTLLWMVASGLECDVKEVCLGSPGIPGTPGSHGLPGRDGRDGIKGDPGPPGPMGPPGGMPGLPGRDGMTGAPGLPGERGEKGEPGERGPPGFPAYLDEELQGTLHEIRHQVLQSQGVLRLQGSVLAVGEKVFSTNGQSVNFDAIKELCARVGGHIAAPRSPEENEAIVSIVKKYNTYAYLGLVEGPTAGDFYYLDGAPVNYTNWYPGEPRGRGKEKCVEIYTDGQWNDKNCLQYRLAICEF", "length": 248, "header": "sp|Q6RXL1-1|SFTPA_BOVIN Isoform 1 of Pulmonary surfactant-associated protein A OS=Bos taurus OX=9913 GN=SFTPA1 PE=2 SV=2 CANONICAL=Q6RXL1-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 194, "start_aa": "Thr", "end_pos": 194, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr194", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 207, "start_aa": "Asn", "end_pos": 207, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn207", "evidence": [ { "id": "Q6RXL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 35, "start_aa": "Thr", "end_pos": 35, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr35", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Assignment of the surfactant protein A gene (SFTPA) to bovine chromosome 28q1.8-->q1.9 by radiation hybrid mapping.", "journal": "Cytogenetic and genome research", "date": "2004", "authors": "Gjerstorff M, Dueholm B, Bendixen C, Holmskov U, Hansen S", "evidence": [ { "database": "RefSeq", "id": "NP_001071306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071306" } ], "reference": [ { "type": "PubMed", "id": "15222309", "url": "https://glygen.org/publication/PubMed/15222309" } ] } ], "pathway": [ { "id": "bta:407213", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:407213", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q6RXL1", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1" } ], "pmid": "" }, { "name": "multivesicular body", "id": "GO:0005771", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005771", "evidence": [ { "database": "UniProtKB", "id": "Q6RXL1", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q6RXL1", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1" } ], "pmid": "" }, { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "Q6RXL1", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": 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"id": "PRU00040", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00040" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C-type lectin", "eco_id": "ECO_0000255", "start_pos": 132, "end_pos": 248, "start_aa": "Leu", "end_aa": "Phe", "glycosite_overlap": "Asn207" } ], "binding_sites": [ { "evidence": [ { "id": "Q6RXL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1#function" }, { "id": "Q6RXL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1" } ], "binding_site_uniprot": 215, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 215, "end_pos": 215, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q6RXL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1#function" }, { "id": "Q6RXL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1" } ], "binding_site_uniprot": 217, "amino_acid": "Arg", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 217, "end_pos": 217, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q6RXL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1#function" }, { "id": "Q6RXL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1" } ], "binding_site_uniprot": 234, "amino_acid": "Asn", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 234, "end_pos": 234, "start_aa": "Asn", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q6RXL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1#function" }, { "id": "Q6RXL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6RXL1" } ], "binding_site_uniprot": 235, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000250", "start_pos": 235, "end_pos": 235, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [ 207 ], "o_linked_sites": [ 35, 194 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 207, "end_pos": 209 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", 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"subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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"Telethonin", "type": "recommended", "evidence": [ { "id": "Q6T8D8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6T8D8/entry#names_and_taxonomy" } ] }, { "name": "Titin cap protein", "type": "synonym", "evidence": [ { "id": "Q6T8D8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6T8D8/entry#names_and_taxonomy" } ] }, { "name": "telethonin", "type": "synonym", "evidence": [ { "id": "NP_001014915", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014915" } ] }, { "name": "titin cap protein", "type": "synonym", "evidence": [ { "id": "NP_001014915", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014915" } ] } ], "function": [ { "annotation": "Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q6T8D8", "url": "https://www.uniprot.org/uniprotkb/Q6T8D8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6T8D8", "url": "https://www.uniprot.org/uniprotkb/Q6T8D8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TCAP", "url": "https://www.uniprot.org/uniprotkb/Q6T8D8", "locus": { "chromosome": "19", "start_pos": 40043107, "end_pos": 40041901, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011730", "url": "https://www.ensembl.org/id/ENSBTAG00000011730" } ] } } ], "crossref": [ { "id": "Q6T8D8", "url": "https://alphafold.ebi.ac.uk/entry/Q6T8D8", "database": 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"categories": [ "Protein Classification" ] }, { "id": "PTHR15143", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15143", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15143:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15143:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09470", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09470", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-390522", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390522", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001014915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014915", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q6T8D8", "url": "https://www.uniprot.org/uniprotkb/Q6T8D8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6T8D8-1", "url": "https://www.uniprot.org/uniprotkb/Q6T8D8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATSELSCLVSEENCERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHRQGQCQALVQRSPWLVMRMGILGRGLQEYQLPYQRVLPLPIFTPAKVGTKEEREETPIQLQELLALETALGGQCVDRQDVAEITKQLPPVVPVSKPGTLRRSLSRSMSQEAQRG", "length": 166, "header": "sp|Q6T8D8-1|TELT_BOVIN Isoform 1 of Telethonin OS=Bos taurus OX=9913 GN=TCAP PE=2 SV=1 CANONICAL=Q6T8D8-1" }, "isoforms": [ { "isoform_ac": "Q6T8D8-1", "url": "https://www.uniprot.org/uniprotkb/Q6T8D8/entry#Q6T8D8-1", "sequence": { "sequence": "MATSELSCLVSEENCERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHRQGQCQALVQRSPWLVMRMGILGRGLQEYQLPYQRVLPLPIFTPAKVGTKEEREETPIQLQELLALETALGGQCVDRQDVAEITKQLPPVVPVSKPGTLRRSLSRSMSQEAQRG", "length": 166, "header": "sp|Q6T8D8-1|TELT_BOVIN Isoform 1 of Telethonin OS=Bos taurus OX=9913 GN=TCAP PE=2 SV=1 CANONICAL=Q6T8D8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 39, "end_pos": 39, "kinase_uniprot_canonical_ac": 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"database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0ABK0LAZ2-1", "protein_name": "Telethonin", "gene_name": "Tcap", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "LGFLYRLGYVILLVKGPHYDKPLSSLNKGEQAEDSAKVARGCPRAWSEVVFAACQTPGGATLRTQAPSRASRRLWKLTSDLRAIRIWVPQPPPWIQSPITTKLSCQVSEENQERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHRQGQCQAVVQRSPWLVMRLGILGRGLQEYQLPYQRVLPLPIFTPTKVGATKEEREETPIQLRELLALETALGGQCVERQDVAEITKQLPPVVPVSKPGPLRRTLSRSMSQEAQRG", "length": 264 }, "evidence": [ { "id": "Q6T8D8", "url": "https://omabrowser.org/oma/group/Q6T8D8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H5X7-1", "protein_name": "Telethonin", "gene_name": "Tcap", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MATSELSCQVSEENQERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHRQGQCQAVVQRSPWLVMRLGILGRGLQEYQLPYQRVLPLPIFTPTKVGAAKEEREETPIQLRELLALETALGGQCVERQDVAEITKQLPPVVPVSKPGTLRRTLSRSMSQEAQRG", "length": 167 }, "evidence": [ { "id": "Q6T8D8", "url": "https://omabrowser.org/oma/group/Q6T8D8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O15273-1", "protein_name": "Telethonin", "gene_name": "TCAP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATSELSCEVSEENCERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHQQGQCQVLVQRSPWLMMRMGILGRGLQEYQLPYQRVLPLPIFTPAKMGATKEEREDTPIQLQELLALETALGGQCVDRQEVAEITKQLPPVVPVSKPGALRRSLSRSMSQEAQRG", "length": 167 }, "evidence": [ { "id": "Q6T8D8", "url": "https://omabrowser.org/oma/group/Q6T8D8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O70548-1", "protein_name": "Telethonin", "gene_name": "Tcap", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATSELSCQVSEENQERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHRQGQCQAVVQRSPWLVMRLGILGRGLQEYQLPYQRVLPLPIFTPTKVGASKEEREETPIQLRELLALETALGGQCVERQDVAEITKQLPPVVPVSKPGPLRRTLSRSMSQEAQRG", "length": 167 }, "evidence": [ { "id": "Q6T8D8", "url": "https://omabrowser.org/oma/group/Q6T8D8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "detection of muscle stretch", "id": "GO:0035995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035995", "evidence": [ { "database": "UniProtKB", "id": "Q6T8D8", "url": "https://www.uniprot.org/uniprotkb/Q6T8D8" } ], "pmid": "" }, { "name": "skeletal muscle contraction", "id": "GO:0003009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003009", "evidence": [ { "database": "UniProtKB", "id": "Q6T8D8", "url": "https://www.uniprot.org/uniprotkb/Q6T8D8" } ], "pmid": "" }, { "name": "skeletal muscle thin filament 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"GO:0007512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007512", "evidence": [ { "database": "UniProtKB", "id": "Q6T8D8", "url": "https://www.uniprot.org/uniprotkb/Q6T8D8" } ], "pmid": "" }, { "name": "skeletal muscle myosin thick filament assembly", "id": "GO:0030241", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030241", "evidence": [ { "database": "UniProtKB", "id": "Q6T8D8", "url": "https://www.uniprot.org/uniprotkb/Q6T8D8" } ], "pmid": "" }, { "name": "sarcomerogenesis", "id": "GO:0048769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048769", "evidence": [ { "database": "UniProtKB", "id": "Q6T8D8", "url": "https://www.uniprot.org/uniprotkb/Q6T8D8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "Q6T8D8", "url": "https://www.uniprot.org/uniprotkb/Q6T8D8" } ], "pmid": 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"total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q6XBT4-1", "uniprot_ac": "Q6XBT4", "uniprot_id": "USF1_BOVIN", "mass": { "chemical_mass": 33497.0, "monoisotopic_mass": 33497.0 }, "refseq": { "ac": "NP_001001161", "name": "upstream stimulatory factor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001161" }, "gene_names": [ { "name": "USF1", "type": "recommended", "evidence": [ { "id": "Q6XBT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6XBT4" } ] }, { "name": "USF1", "type": "synonym", "evidence": [ { "id": "NP_001001161", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001161" } ] } ], "protein_names": [ { "name": "Upstream stimulatory factor 1", "type": "recommended", "evidence": [ { "id": "Q6XBT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6XBT4/entry#names_and_taxonomy" } ] }, { "name": "upstream stimulatory factor 1", "type": "synonym", "evidence": [ { "id": "NP_001001161", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001161" } ] } ], "function": [ { "annotation": "Bovine upstream stimulatory factor 1 and 2 have roles regulating the prostaglandin G/H synthase-2 promoter in granulosa cells [USF1/USF2]", "evidence": [ { "database": "RefSeq", "id": "NP_001001161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001161" }, { "database": "PubMed", "id": "14660559", "url": "https://glygen.org/publication/PubMed/14660559" } ] }, { "annotation": "Depletion of the USFs by RNAi and expression of a dominant-negative USF mutant, were both associated with a significant decrease in P1.1-dependent reporter gene expression. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001001161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001161" }, { "database": "PubMed", "id": "20082704", "url": "https://glygen.org/publication/PubMed/20082704" } ] }, { "annotation": "Study demonstrates that upstream transcription factor 1 (USF1) is a maternally derived transcription factor required for bovine early embryonic development", "evidence": [ { "database": "RefSeq", "id": "NP_001001161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001161" }, { "database": "PubMed", "id": "25385722", "url": "https://glygen.org/publication/PubMed/25385722" } ] }, { "annotation": "Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.", "evidence": [ { "database": "UniProtKB", "id": "Q6XBT4", "url": "https://www.uniprot.org/uniprotkb/Q6XBT4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6XBT4", "url": "https://www.uniprot.org/uniprotkb/Q6XBT4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "USF1", "url": "https://www.uniprot.org/uniprotkb/Q6XBT4", "locus": { "chromosome": "3", "start_pos": 8442549, "end_pos": 8436890, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017873", "url": "https://www.ensembl.org/id/ENSBTAG00000017873" } ] } } ], "crossref": [ { "id": "Q6XBT4", "url": "https://alphafold.ebi.ac.uk/entry/Q6XBT4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017873", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017873", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18924", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18924", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "407239", "url": "https://www.ncbi.nlm.nih.gov/gene/407239", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051732", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051732", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:407239", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:407239", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GAQVMYR", "url": "https://omabrowser.org/oma/group/GAQVMYR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q6XBT4", "url": "https://www.orthodb.org/?gene=Q6XBT4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46117", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46117", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46117:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46117:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9018519", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9018519", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9824585", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9824585", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001001161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001161", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q6XBT4", "url": "https://www.uniprot.org/uniprotkb/Q6XBT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6XBT4-1", "url": "https://www.uniprot.org/uniprotkb/Q6XBT4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKGQQKTAETEEGTVQIQEGAVATGEDPTSVAIASIQSAATFPDPNVKYVFRTENGGQVMYRVIQVSEGQLDGQTEGTGAISGYPATQSMTQAVIQGAFTSDDAVDTEGTAAETHYTYFPSTAVGDGAGGTTSGSTAAVVTTQGSEALLGQATPPGTGQFFVMMSPQEVLQGGSQRSIAPRTHPYSPKSEAPRTTRDEKRRAQHNEVERRRRDKINNWIVQLSKIIPDCSMESTKSGQSKGGILSKACDYIQELRQSNHRLSEELQGLDQLQLDNDVLRQQVEDLKNKNLLLRAQLRHHGVEVVIKSDSN", "length": 310, "header": "sp|Q6XBT4-1|USF1_BOVIN Isoform 1 of Upstream stimulatory factor 1 OS=Bos taurus OX=9913 GN=USF1 PE=2 SV=1 CANONICAL=Q6XBT4-1" }, "isoforms": [ { "isoform_ac": "Q6XBT4-1", "url": "https://www.uniprot.org/uniprotkb/Q6XBT4/entry#Q6XBT4-1", "sequence": { "sequence": "MKGQQKTAETEEGTVQIQEGAVATGEDPTSVAIASIQSAATFPDPNVKYVFRTENGGQVMYRVIQVSEGQLDGQTEGTGAISGYPATQSMTQAVIQGAFTSDDAVDTEGTAAETHYTYFPSTAVGDGAGGTTSGSTAAVVTTQGSEALLGQATPPGTGQFFVMMSPQEVLQGGSQRSIAPRTHPYSPKSEAPRTTRDEKRRAQHNEVERRRRDKINNWIVQLSKIIPDCSMESTKSGQSKGGILSKACDYIQELRQSNHRLSEELQGLDQLQLDNDVLRQQVEDLKNKNLLLRAQLRHHGVEVVIKSDSN", "length": 310, "header": "sp|Q6XBT4-1|USF1_BOVIN Isoform 1 of Upstream stimulatory factor 1 OS=Bos taurus OX=9913 GN=USF1 PE=2 SV=1 CANONICAL=Q6XBT4-1" }, "locus": { "chromosome": "3", "start_pos": 8441879, "end_pos": 8438860, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023760.7", "url": "https://www.ensembl.org/id/ENSBTAT00000023760.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023760.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023760.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Molecular characterization and role of bovine upstream stimulatory factor 1 and 2 in the regulation of the prostaglandin G/H synthase-2 promoter in granulosa cells.", "journal": "J. Biol. Chem.", "date": "2004", "authors": "Sayasith Khampoune, Bouchard Nadine, Sawadogo Mich\u00e8le, Lussier Jacques G, Sirois Jean", "evidence": [ { "database": "UniProtKB", "id": "Q6XBT4", "url": "https://www.uniprot.org/uniprotkb/Q6XBT4" }, { "database": "RefSeq", "id": "NP_001001161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001161" } ], "reference": [ { "type": "PubMed", "id": "14660559", "url": "https://glygen.org/publication/PubMed/14660559" } ] }, { "title": "Upstream stimulating factors 1 and 2 enhance transcription from the placenta-specific promoter 1.1 of the bovine cyp19 gene.", "journal": "BMC molecular biology", "date": "2010-01-18", "authors": "F\u00fcrbass Rainer, Tomek Wolfgang, Vanselow Jens", "evidence": [ { "database": "RefSeq", "id": "NP_001001161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001161" } ], "reference": [ { "type": "PubMed", "id": "20082704", "url": "https://glygen.org/publication/PubMed/20082704" } ] }, { "title": "Requirement of the 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"uniprot_canonical_ac": "Q6YC49-1", "uniprot_ac": "Q6YC49", "uniprot_id": "S35A3_BOVIN", "mass": { "chemical_mass": 36067.0, "monoisotopic_mass": 36067.0 }, "refseq": { "ac": "NP_001098856", "name": "UDP-N-acetylglucosamine transporter", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098856" }, "gene_names": [ { "name": "SLC35A3", "type": "recommended", "evidence": [ { "id": "Q6YC49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6YC49" } ] }, { "name": "SLC35A3", "type": "synonym", "evidence": [ { "id": "NP_001098856", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098856" } ] } ], "protein_names": [ { "name": "UDP-N-acetylglucosamine transporter", "type": "recommended", "evidence": [ { "id": "Q6YC49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6YC49/entry#names_and_taxonomy" } ] }, { "name": "Golgi UDP-GlcNAc transporter", "type": "synonym", "evidence": [ { "id": "Q6YC49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6YC49/entry#names_and_taxonomy" } ] }, { "name": "Solute carrier family 35 member A3", "type": "synonym", "evidence": [ { "id": "Q6YC49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6YC49/entry#names_and_taxonomy" } ] }, { "name": "UDP-N-acetylglucosamine transporter", "type": "synonym", "evidence": [ { "id": "NP_001098856", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098856" } ] }, { "name": "golgi UDP-GlcNAc transporter", "type": "synonym", "evidence": [ { "id": "NP_001098856", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098856" } ] }, { "name": "solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3", "type": "synonym", "evidence": [ { "id": "NP_001098856", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098856" } ] }, { "name": "solute carrier family 35 member 3", "type": "synonym", "evidence": [ { "id": "NP_001098856", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098856" } ] } ], "function": [ { "annotation": "A defective SLC35A3 gene is associated with severe axial skeletal deformities, symmetric arthrogryposis of the lower limb joints, craniofacial dysmorphism, and cardiac anomalies.", "evidence": [ { "database": "RefSeq", "id": "NP_001098856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098856" }, { "database": "PubMed", "id": "16344554", "url": "https://glygen.org/publication/PubMed/16344554" } ] }, { "annotation": "Transports diphosphate-N-acetylglucosamine (UDP-GlcNAc) from the cytosol into the lumen of the Golgi apparatus, functioning as an antiporter that exchanges UDP-N-acetyl-alpha-D-glucosamine for UMP (By similarity). May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate highly branched, multiantennary complex N-glycans and keratan sulfate (PubMed:16344554). However, the exact role of SLC35A3 still needs to be elucidated, it could be a member of a catalytically more efficient multiprotein complex rather than function independently as a single transporter (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q6YC49", "url": "https://www.uniprot.org/uniprotkb/Q6YC49#function" }, { "database": "PubMed", "id": "16344554", "url": "https://glygen.org/publication/PubMed/16344554" }, { "database": "UniProtKB", "id": "Q9Y2D2", "url": "https://www.uniprot.org/uniprotkb/Q9Y2D2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q6YC49", "url": "https://www.uniprot.org/uniprotkb/Q6YC49" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC35A3", "url": "https://www.uniprot.org/uniprotkb/Q6YC49", "locus": { "chromosome": "3", "start_pos": 43249864, "end_pos": 43299517, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012454", "url": "https://www.ensembl.org/id/ENSBTAG00000012454" } ] } } ], "crossref": [ { "id": "Q6YC49", "url": "https://alphafold.ebi.ac.uk/entry/Q6YC49", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012454", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012454", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "520918", "url": "https://www.ncbi.nlm.nih.gov/gene/520918", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520918", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520918", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AIMYVIQ", "url": "https://omabrowser.org/oma/group/AIMYVIQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q6YC49", "url": "https://www.orthodb.org/?gene=Q6YC49", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10231", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10231", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04142", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04142", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-727802", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-727802", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001098856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098856", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "72695", "url": "https://www.rhea-db.org/rhea/72695", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q6YC49", "url": "https://www.uniprot.org/uniprotkb/Q6YC49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6YC49-1", "url": "https://www.uniprot.org/uniprotkb/Q6YC49-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSANLKYLSLGILVFQTTSLVLTMRYSRTLKEEGPRYLSSTAVVVAELLKIMACILLVYKDSKCSLRALNRILHDEILNKPMETLKLAIPSGIYTLQNNLLYVALSNLDAATYQVTYQLKILTTALFSVSMLSKKLGVYQWLSLVILMTGVAFVQWPSDSQELNSKELSAGSQFVGLMAVLTACFSSGFAGVYFEKILKETKQSVWIRNIQLGFFGSIFGLMGVYVYDGELVSKNGFFQGYNRLTWIVVVLQALGGLVIAAVIKYADNILKGFATSLSIILSTLISYFWLQDFVPTSVFFLGAILVITATFLYGYDPKPAGNPTKA", "length": 326, "header": "sp|Q6YC49-1|S35A3_BOVIN Isoform 1 of UDP-N-acetylglucosamine transporter OS=Bos taurus OX=9913 GN=SLC35A3 PE=1 SV=1 CANONICAL=Q6YC49-1" }, "isoforms": [ { "isoform_ac": "Q6YC49-1", "url": "https://www.uniprot.org/uniprotkb/Q6YC49/entry#Q6YC49-1", "sequence": { "sequence": "MSANLKYLSLGILVFQTTSLVLTMRYSRTLKEEGPRYLSSTAVVVAELLKIMACILLVYKDSKCSLRALNRILHDEILNKPMETLKLAIPSGIYTLQNNLLYVALSNLDAATYQVTYQLKILTTALFSVSMLSKKLGVYQWLSLVILMTGVAFVQWPSDSQELNSKELSAGSQFVGLMAVLTACFSSGFAGVYFEKILKETKQSVWIRNIQLGFFGSIFGLMGVYVYDGELVSKNGFFQGYNRLTWIVVVLQALGGLVIAAVIKYADNILKGFATSLSIILSTLISYFWLQDFVPTSVFFLGAILVITATFLYGYDPKPAGNPTKA", "length": 326, "header": "sp|Q6YC49-1|S35A3_BOVIN Isoform 1 of UDP-N-acetylglucosamine transporter OS=Bos taurus OX=9913 GN=SLC35A3 PE=1 SV=1 CANONICAL=Q6YC49-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "A missense mutation in the bovine SLC35A3 gene, encoding a UDP-N-acetylglucosamine transporter, causes complex vertebral malformation.", "journal": "Genome research", "date": "2006", "authors": "Thomsen B, Horn P, Panitz F, Bendixen E, Petersen AH, Holm LE, Nielsen VH, Agerholm JS, Arnbjerg J, Bendixen C", "evidence": [ { "database": "UniProtKB", "id": "Q6YC49", "url": "https://www.uniprot.org/uniprotkb/Q6YC49" }, { "database": "RefSeq", "id": "NP_001098856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098856" } ], "reference": [ { "type": "PubMed", "id": "16344554", "url": "https://glygen.org/publication/PubMed/16344554" } ] } ], "pathway": [ { "id": "bta:520918", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520918", "resource": "KEGG Pathway" }, { "id": "R-BTA-727802", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-727802", "resource": "Reactome", "description": "Transport of nucleotide sugars" } ], "orthologs": [ { "uniprot_canonical_ac": "F1NZW9-1", "protein_name": "Solute carrier family 35 member A3", "gene_name": "SLC35A3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSTNLKYLSLGILVFQTTSLVLTMRYSRTLKEEGPRYLSSTAVVLAELLKILSCVLLVYKDSKCNLRTLNRVLHDEILNKPMETLKLAIPSGIYTLQNNLLYVALSNLDAATYQVTYQLKILTTALFSVSMLSKKLGIYQWLSLVILMTGVAFVQWPSDSQATAAKEHSAGSQFVGLMAVLIACFSSGFAGVYFEKILKETKQSVWIRNIQLGFFGSIFGLMGVYIYDGEQLSKDGFFQGYNKLTWIVVVLQALGGLVIAAVIKYADNILKGFATSLSIILSTLISYFWLQDFVPTSVFFFGAILVIAATFLYGYDPKPAGNPTKA", "length": 326 }, "evidence": [ { "id": "Q6YC49", "url": "https://omabrowser.org/oma/group/Q6YC49/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6AXR5-1", "protein_name": "UDP-N-acetylglucosamine transporter", "gene_name": "Slc35a3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSANLKYLSLGILVFQTTSLVLTMRYSRTLKEEGPRYLSSTAVVVAEFLKIMACIFLVYKDSKCSVRTLNRVLHDEILNKPMETLKLAIPSGIYTLQNNLLYVALSNLDAATYQVTYQLKILTTALFSVSMLGKKLGMYQWLSLVILMAGVAFVQWPSDSQELNSKDLSTGSQFVGLMAVLIACFSSGFAGVYFEKILKETKQSVWIRNIQLGFFGSIFGLMGVYVYDGELVSKNGFFQGYNQLTWIVVVLQALGGLVIAAVIKYADNILKGFATSLSIILSTIISYFWLQDFVPTSVFFLGAILVIAATFLYGYDPKPAGNPTKA", "length": 326 }, "evidence": [ { "id": "Q6YC49", "url": "https://omabrowser.org/oma/group/Q6YC49/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R1T4-1", "protein_name": "UDP-N-acetylglucosamine transporter", "gene_name": "Slc35a3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSANLKYLSLGILVFQTTSLVLTMRYSRTLKEEGPRYLSSTAVVVAEFLKIMACIFLVYKDSKCSVRALNRVLHDEILNKPMETLKLAIPSGIYTLQNNLLYVALSNLDAATYQVTYQLKILTTALFSVSMLGKKLGVYQWLSLVILMAGVAFVQWPSDSQELNSKDLSTGSQFVGLMAVLTACFSSGFAGVYFEKILKETKQSVWIRNIQLGFFGSIFGLMGVYVYDGELVSKNGFFQGYNQLTWIVVALQALGGLVIAAVIKYADNILKGFATSLSIILSTIISYFWLQDFVPTSVFFLGAILVIAATFLYGYDPKPAGNPTKA", "length": 326 }, "evidence": [ { "id": "Q6YC49", "url": "https://omabrowser.org/oma/group/Q6YC49/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y2D2-1", "protein_name": "UDP-N-acetylglucosamine transporter", "gene_name": "SLC35A3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFANLKYVSLGILVFQTTSLVLTMRYSRTLKEEGPRYLSSTAVVVAELLKIMACILLVYKDSKCSLRALNRVLHDEILNKPMETLKLAIPSGIYTLQNNLLYVALSNLDAATYQVTYQLKILTTALFSVSMLSKKLGVYQWLSLVILMTGVAFVQWPSDSQLDSKELSAGSQFVGLMAVLTACFSSGFAGVYFEKILKETKQSVWIRNIQLGFFGSIFGLMGVYIYDGELVSKNGFFQGYNRLTWIVVVLQALGGLVIAAVIKYADNILKGFATSLSIILSTLISYFWLQDFVPTSVFFLGAILVITATFLYGYDPKPAGNPTKA", "length": 325 }, "evidence": [ { "id": "Q6YC49", "url": "https://omabrowser.org/oma/group/Q6YC49/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q6YC49", "url": "https://www.uniprot.org/uniprotkb/Q6YC49" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "Q6YC49", "url": "https://www.uniprot.org/uniprotkb/Q6YC49" } ], "pmid": "" }, { "name": "UDP-N-acetylglucosamine transmembrane transport", "id": "GO:1990569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990569", "evidence": [ { "database": "UniProtKB", "id": "Q6YC49", "url": "https://www.uniprot.org/uniprotkb/Q6YC49" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "antiporter activity", "id": "GO:0015297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015297", "evidence": [ { "database": "UniProtKB", "id": "Q6YC49", "url": "https://www.uniprot.org/uniprotkb/Q6YC49" } ], "pmid": "" }, { "name": "UDP-galactose transmembrane transporter activity", "id": "GO:0005459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005459", "evidence": [ { "database": "UniProtKB", "id": "Q6YC49", "url": "https://www.uniprot.org/uniprotkb/Q6YC49" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "72695", "name": "", "equation": "UMP(out) + UDP-N-acetyl-alpha-D-glucosamine(in) = UMP(in) + UDP-N-acetyl-alpha-D-glucosamine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "72695", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/72695" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q6YC49-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 326, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q6YC49-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q6YC49" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q70IB2-1", "uniprot_ac": "Q70IB2", "uniprot_id": "RNS10_BOVIN", "mass": { "chemical_mass": 23363.0, "monoisotopic_mass": 23363.0 }, "refseq": { "ac": "XP_002690790", "name": "inactive ribonuclease-like protein 10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690790" }, "gene_names": [ { "name": "RNASE10", "type": "recommended", "evidence": [ { "id": "Q70IB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q70IB2" } ] }, { "name": "RNASE10", "type": "synonym", "evidence": [ { "id": "XP_002690790", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690790" } ] } ], "protein_names": [ { "name": "Inactive ribonuclease-like protein 10", "type": "recommended", "evidence": [ { "id": "Q70IB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q70IB2/entry#names_and_taxonomy" } ] }, { "name": "Protein Train A", "type": "synonym", "evidence": [ { "id": "Q70IB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q70IB2/entry#names_and_taxonomy" } ] }, { "name": "inactive ribonuclease-like protein 10", "type": "synonym", "evidence": [ { "id": "XP_002690790", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690790" } ] } ], "function": [ { "annotation": "Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q70IB2", "url": "https://www.uniprot.org/uniprotkb/Q70IB2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q70IB2", "url": "https://www.uniprot.org/uniprotkb/Q70IB2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RNASE10", "url": "https://www.uniprot.org/uniprotkb/Q70IB2", "locus": { "chromosome": "10", "start_pos": 26581549, "end_pos": 26606014, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000056146", "url": "https://www.ensembl.org/id/ENSBTAG00000056146" } ] } } ], "crossref": [ { "id": "Q70IB2", "url": "https://alphafold.ebi.ac.uk/entry/Q70IB2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032869", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032869", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00163", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00163", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100140137", "url": "https://www.ncbi.nlm.nih.gov/gene/100140137", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036816", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036816", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100140137", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140137", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GQVTPHC", "url": "https://omabrowser.org/oma/group/GQVTPHC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q70IB2", "url": "https://www.orthodb.org/?gene=Q70IB2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11437", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11437", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11437:SF63", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11437:SF63", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00074", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00074", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002690790", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690790", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q70IB2", "url": "https://www.uniprot.org/uniprotkb/Q70IB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q70IB2-1", "url": "https://www.uniprot.org/uniprotkb/Q70IB2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLTLVQIFFMMLLLLLGLGVGLGVGLQMAAAVLEESDQLLDEFLSSDSQDKAEATKEGLASRSTETLLVSNKEVVQPEDTIISEDEVGGDRMLRAEVLLHSNKDYLRSDVMDRECNALMALKVKSKDHTCIPQYIFIHEELDAVKAVCKSPAVACDLKGGKCHKSPRPFDLTFCKLSKSGQVIPHCNYVTFILEKYILMSCSDMKVQITS", "length": 211, "header": "sp|Q70IB2-1|RNS10_BOVIN Isoform 1 of Inactive ribonuclease-like protein 10 OS=Bos taurus OX=9913 GN=RNASE10 PE=2 SV=2 CANONICAL=Q70IB2-1" }, "isoforms": [ { "isoform_ac": "Q70IB2-1", "url": "https://www.uniprot.org/uniprotkb/Q70IB2/entry#Q70IB2-1", "sequence": { "sequence": "MKLTLVQIFFMMLLLLLGLGVGLGVGLQMAAAVLEESDQLLDEFLSSDSQDKAEATKEGLASRSTETLLVSNKEVVQPEDTIISEDEVGGDRMLRAEVLLHSNKDYLRSDVMDRECNALMALKVKSKDHTCIPQYIFIHEELDAVKAVCKSPAVACDLKGGKCHKSPRPFDLTFCKLSKSGQVIPHCNYVTFILEKYILMSCSDMKVQITS", "length": 211, "header": "sp|Q70IB2-1|RNS10_BOVIN Isoform 1 of Inactive ribonuclease-like protein 10 OS=Bos taurus OX=9913 GN=RNASE10 PE=2 SV=2 CANONICAL=Q70IB2-1" }, "locus": { "chromosome": "10", "start_pos": 26596680, "end_pos": 26596048, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093918.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093918.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080158.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080158.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Identification of a member of a new RNase A family specifically secreted by epididymal caput epithelium.", "journal": "Biol. Reprod.", "date": "2004", "authors": "Castella S, Fouchecourt S, Teixeira-Gomes AP, Vinh J, Belghazi M, Dacheux F, Dacheux JL", "evidence": [ { "database": "UniProtKB", "id": "Q70IB2", "url": "https://www.uniprot.org/uniprotkb/Q70IB2" } ], "reference": [ { "type": "PubMed", "id": "14561640", "url": "https://glygen.org/publication/PubMed/14561640" } ] }, { "title": "A whole-genome assembly of the domestic cow, Bos taurus.", "journal": "Genome Biol.", "date": "2009", "authors": "Zimin Aleksey V, Delcher Arthur L, Florea Liliana, Kelley David R, Schatz Michael C, Puiu Daniela, Hanrahan Finnian, Pertea Geo, Van Tassell Curtis P, Sonstegard Tad S, Mar\u00e7ais Guillaume, Roberts Michael, Subramanian Poorani, Yorke James A, Salzberg Steven L", "evidence": [ { "database": "UniProtKB", "id": "Q70IB2", "url": "https://www.uniprot.org/uniprotkb/Q70IB2" } ], "reference": [ { "type": "PubMed", "id": "19393038", "url": "https://glygen.org/publication/PubMed/19393038" } ] } ], "pathway": [ { "id": "bta:100140137", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140137", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061IKF0-1", "protein_name": "Inactive ribonuclease-like protein 10", "gene_name": "Rnase10", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKVTLVHMLFMMLLLLLGLGLGLGLGLHMAAAVLQDSDQPLSEFWPGDSKDTAEATEEGEGTWTTKAPALGYKEMAQSNWLEETVLNEDDVGGSRMLGTKALSQSKQDFKIDLNARDCNTLMISKMKEYNHTCINHYTFIHETPSTVQEVCNSPVIACDLKGSKCHKSPRPFELTVCLLSKPGQVVPNCHYLTYITEKYIITTCDGSTQIKMV", "length": 213 }, "evidence": [ { "id": "Q70IB2", "url": "https://omabrowser.org/oma/group/Q70IB2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5GAM0-1", "protein_name": "Inactive ribonuclease-like protein 10", "gene_name": "Rnase10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKVTLVHLLFMMLLLLLGLGVGLGLGLHMAAAILENQPLDEFWPSDSQDTAEATEEGQGTRTTEALVLDNKEMAVPVWSEDTVLSEDEVGGSRMLRAKTLLQSKQGYLKFDLNIRDCNVMMAHKIKEHNQSCINDYTFIHEDPSTVGAVCNSPLVDCDLKGGKCHKSPRPFDLTLCKLAKPGQVTPNCHYLTYITEKVIIITCNNTKQLEIK", "length": 212 }, "evidence": [ { "id": "Q70IB2", "url": "https://omabrowser.org/oma/group/Q70IB2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5GAN6-1", "protein_name": "Inactive ribonuclease-like protein 10", "gene_name": "RNASE10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKLNLVQIFFMLLMLLLGLGMGLGLGLHMATAVLEESDQPLNEFWSSDSQDKAEATEEGDGTQTTETLVLSNKEVVQPGWPEDPILGEDEVGGNKMLRASALFQSNKDYLRLDQTDRECNDMMAHKMKEPSQSCIAQYAFIHEDLNTVKAVCNSPVIACELKGGKCHKSSRPFDLTLCELSQPDQVTPNCNYLTSVIKKHIIITCNDMKRQLPTGQ", "length": 216 }, "evidence": [ { "id": "Q70IB2", "url": "https://omabrowser.org/oma/group/Q70IB2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8SPJ0-1", "protein_name": "Inactive ribonuclease-like protein 10", "gene_name": "RNASE10", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKLTLVQFFFMMLLLLLGLGVGLGLGLQMAAAVLEESDQLLSEFQSSDSQDKTQATKKGAGTRTMETLLLSDNVVMQPEETILSEDEVGGNKMLRAQAFSQSYPNYLRSDLMDRECNTLMAKKMKPYNHTCISQYIFIHEEPDEIKAVCKSPPVACELKGGKCHKSARPFDLTFCKLSKPGQVTPHCNYVTFLLEKHILISCNDMKVQVMSGS", "length": 213 }, "evidence": [ { "id": "Q70IB2", "url": "https://omabrowser.org/oma/group/Q70IB2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9D5A9-1", "protein_name": "Inactive ribonuclease-like protein 10", "gene_name": "Rnase10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKVTLVHLLFMMLLLLLGLGLGLGLGLHMAAAVLEDQPLNEFWPSDSQNTEEGEGIWTTEGLALGYKEMAQPVWPEEAVLSEDEVGGSRMLRAEPRFQSKQDYLKFDLSVRDCNTMMAHKIKEPNQSCINQYTFIHEDPNTVKAVCNGSLVDCDLQGGKCYKSPRPFDLTLCKLAKPGQVTPNCHYLTYITEKSIFMTCNDKRQLETK", "length": 208 }, "evidence": [ { "id": "Q70IB2", "url": "https://omabrowser.org/oma/group/Q70IB2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "positive regulation of cell-cell adhesion", "id": "GO:0022409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022409", "evidence": [ { "database": "UniProtKB", "id": "Q70IB2", "url": "https://www.uniprot.org/uniprotkb/Q70IB2" } ], "pmid": "" }, { "name": "defense response to Gram-positive bacterium", "id": "GO:0050830", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050830", "evidence": [ { "database": "UniProtKB", "id": "Q70IB2", "url": "https://www.uniprot.org/uniprotkb/Q70IB2" } ], "pmid": "" }, { "name": "single fertilization", "id": "GO:0007338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007338", "evidence": [ { "database": "UniProtKB", "id": "Q70IB2", "url": "https://www.uniprot.org/uniprotkb/Q70IB2" } ], "pmid": "" }, { "name": "heterotypic cell-cell adhesion", "id": "GO:0034113", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034113", "evidence": [ { "database": "UniProtKB", "id": "Q70IB2", "url": "https://www.uniprot.org/uniprotkb/Q70IB2" } ], "pmid": "" }, { "name": "positive regulation of flagellated sperm motility", "id": "GO:1902093", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902093", "evidence": [ { "database": "UniProtKB", "id": "Q70IB2", "url": "https://www.uniprot.org/uniprotkb/Q70IB2" } ], "pmid": "" }, { "name": "regulation of fertilization", "id": "GO:0080154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080154", "evidence": [ { "database": "UniProtKB", "id": "Q70IB2", "url": "https://www.uniprot.org/uniprotkb/Q70IB2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q70IB2", "url": "https://www.uniprot.org/uniprotkb/Q70IB2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "Q70IB2", "url": "https://www.uniprot.org/uniprotkb/Q70IB2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q70IB2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 211, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q70IB2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q70IB2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q75NY9-1", "uniprot_ac": "Q75NY9", "uniprot_id": "SC16B_BOVIN", "mass": { "chemical_mass": 117174.0, "monoisotopic_mass": 117174.0 }, "refseq": {}, "gene_names": [ { "name": "SEC16B", "type": "recommended", "evidence": [ { "id": "Q75NY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q75NY9" } ] }, { "name": "RGPR", "type": "synonym", "evidence": [ { "id": "Q75NY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q75NY9" } ] } ], "protein_names": [ { "name": "Protein transport protein Sec16B", "type": "recommended", "evidence": [ { "id": "Q75NY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q75NY9/entry#names_and_taxonomy" } ] }, { "name": "RGPR-p117", "type": "synonym", "evidence": [ { "id": "Q75NY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q75NY9/entry#names_and_taxonomy" } ] }, { "name": "Regucalcin gene promoter region-related protein p117", "type": "synonym", "evidence": [ { "id": "Q75NY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q75NY9/entry#names_and_taxonomy" } ] }, { "name": "SEC16 homolog B", "type": "synonym", "evidence": [ { "id": "Q75NY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q75NY9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes.", "evidence": [ { "database": "UniProtKB", "id": "Q75NY9", "url": "https://www.uniprot.org/uniprotkb/Q75NY9#function" }, { "database": "UniProtKB", "id": "Q96JE7", "url": "https://www.uniprot.org/uniprotkb/Q96JE7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q75NY9", "url": "https://www.uniprot.org/uniprotkb/Q75NY9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SEC16B", "url": "https://www.uniprot.org/uniprotkb/Q75NY9", "locus": { "chromosome": "16", "start_pos": 59319858, "end_pos": 59363661, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000854", "url": "https://www.ensembl.org/id/ENSBTAG00000000854" } ] } } ], "crossref": [ { "id": "Q75NY9", "url": "https://alphafold.ebi.ac.uk/entry/Q75NY9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd09233", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09233", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "404548", "url": "https://www.ncbi.nlm.nih.gov/gene/404548", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR024298", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024298", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:404548", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404548", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q75NY9", "url": "https://www.orthodb.org/?gene=Q75NY9", "database": "OrthoDB", "categories": [ "Protein Classification" 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"MEPWIPQWLPQPSGRPPAPSKDPDRGLWKDRYYQPIPHSWHNGERVHQRQDVGRSPQPQQDPREDLQEPHYAARSGEWRPPVSGVDYYEGGYPSQLYSRWSIEDLYQSYYSPALREEYAYGSYYYHGHPQQLQEERVPRQGSPYIWQEDHRDQKYLNDHQHENQNSPFGTNRETQLQSKSRNPYKDSPASNSGQERPEDLFMESPLTGAQKNKLSLMEESNLLWQHESGLTSSSYELSQYMADASELCDPMTSAVWSPVQAEDISAAGPKEPMKFYVPHMPVSFGPGGQLVCVSPSSPSDGQTALVELHSMEVILNDSEEQEEMRTFSGPLIREDVHKVDIMTFCQQKAAQSHKSETPGSRDSALLWQLLVLLCRQNGSMVGSDIAELLMQDWKKLEKYKRQPPVANLINLTDEDWPVLSSGTRDLLTGEILPSVETPAQILEKFTKLLYYGRKKEALEWAMKNHLWGHALFLASKMDPRTHSRVMSGFTSTLALNDPLQTLFQLMSGRIPQAATCCGDKQWGDWRPHLAVILSNQGGDPELYQRTIVAMGDTLAGKGLVEAAHFCYLMAHVPFGYYTVKTDYLALLGSSHSQEFLKSATTEAIQRTEIFEYCQMLGRPKSFIPSFQVYKLLYASRLADYGLTSQALHYCEPVGTALLSHGESSHPVLLVELIKLAERLKLSDPLVLERRRHRGDRDLEPDWCVHLRGHHRELQQKEAGDIGRPQSAQAVISEARKTPENTFYQDLSGPQGNSEAYGDRSALWPTLEQSGPAQLSPQQPRSYPTGGGSGQMGVPVPLYSVPETHLLGTSGSMAVTGAPGGTAWEEAQQIHLPPVSPETLQHPDGQKAISRPQVPLIPRARSISESSIVSVKEDEEEPPRRQIKIFLKYRPERKPEREGDTKSSGFGWFSWFRSKPTHNASPSGEEDSSDSPDSEEMPRAASLPQPSPSLSLTPSPDPQSLLGASAFSRDTGGDEVRGSVSGVGTAEGPGSGGLSGPEGVSTELCLNAGVLLPPPSVKGSVPLYNPSQVPQLSTVTSLNRPNRLAQRRYPTQS", "length": 1052, "header": "sp|Q75NY9-1|SC16B_BOVIN Isoform 1 of Protein transport protein Sec16B OS=Bos taurus OX=9913 GN=SEC16B PE=2 SV=1 CANONICAL=Q75NY9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 142, "end_pos": 142, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q75NY9", "url": "https://www.uniprot.org/uniprotkb/Q75NY9" } ], "site_lbl": "Ser142" }, { "start_pos": 166, "end_pos": 166, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q75NY9", "url": "https://www.uniprot.org/uniprotkb/Q75NY9" } ], "site_lbl": "Ser166" }, { "start_pos": 187, "end_pos": 187, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q75NY9", "url": "https://www.uniprot.org/uniprotkb/Q75NY9" } ], "site_lbl": "Ser187" }, { "start_pos": 190, "end_pos": 190, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q75NY9", "url": "https://www.uniprot.org/uniprotkb/Q75NY9" } ], "site_lbl": "Ser190" }, { "start_pos": 253, "end_pos": 253, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q75NY9", "url": "https://www.uniprot.org/uniprotkb/Q75NY9" } ], "site_lbl": "Ser253" }, { "start_pos": 257, "end_pos": 257, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q75NY9", "url": "https://www.uniprot.org/uniprotkb/Q75NY9" } ], "site_lbl": "Ser257" }, { "start_pos": 55, "end_pos": 55, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", 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"Ser866" }, { "start_pos": 869, "end_pos": 869, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q75NY9", "url": "https://www.uniprot.org/uniprotkb/Q75NY9" } ], "site_lbl": "Ser869" } ], "glycation": [], "keywords": [], "publication": [ { "title": "A novel regucalcin gene promoter region-related protein: comparison of nucleotide and amino acid sequences in vertebrate species.", "journal": "Int. J. Mol. Med.", "date": "2005", "authors": "Sawada Natsumi, Yamaguchi Masayoshi", "evidence": [ { "database": "UniProtKB", "id": "Q75NY9", "url": "https://www.uniprot.org/uniprotkb/Q75NY9" } ], "reference": [ { "type": "PubMed", "id": "15583834", "url": "https://glygen.org/publication/PubMed/15583834" } ] } ], "pathway": [ { "id": "bta:404548", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404548", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q75NY9", "url": "https://www.uniprot.org/uniprotkb/Q75NY9" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q75NY9", "url": "https://www.uniprot.org/uniprotkb/Q75NY9" } ], "pmid": "" }, { "name": "ER to Golgi transport vesicle membrane", "id": "GO:0012507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012507", "evidence": [ { "database": "UniProtKB", "id": "Q75NY9", "url": "https://www.uniprot.org/uniprotkb/Q75NY9" } ], "pmid": "" }, { "name": "endoplasmic reticulum exit site", "id": "GO:0070971", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070971", "evidence": [ { "database": "UniProtKB", "id": "Q75NY9", "url": "https://www.uniprot.org/uniprotkb/Q75NY9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "Q75NY9", "url": "https://www.uniprot.org/uniprotkb/Q75NY9" } ], "pmid": "" }, { "name": "peroxisome organization", "id": "GO:0007031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007031", "evidence": [ { "database": 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"id": "GO:0043495", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043495", "evidence": [ { "database": "UniProtKB", "id": "Q75NY9", "url": "https://www.uniprot.org/uniprotkb/Q75NY9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 316, "end_pos": 318, "annotation": "n_glycosylation_sequon" }, { "start_pos": 377, "end_pos": 379, "annotation": "n_glycosylation_sequon" }, { "start_pos": 410, "end_pos": 412, "annotation": "n_glycosylation_sequon" }, { "start_pos": 918, "end_pos": 920, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q75NY9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1052, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q75NY9-F1.pdb", "url_external": 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sapiens", "sequence": { "sequence": "MSMGLEITGTALAVLGWLGTIVCCALPMWRVSAFIGSNIITSQNIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALIVVAILLAAFGLLVALVGAQCTNCVQDDTAKAKITIVAGVLFLLAALLTLVPVSWSANTIIRDFYNPVVPEAQKREMGAGLYVGWAAAALQLLGGALLCCSCPPREKKYTATKVVYSAPRSTGPGASLGTGYDRKDYV", "length": 220 }, "evidence": [ { "id": "Q765N9", "url": "https://omabrowser.org/oma/group/Q765N9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q63400-1", "protein_name": "Claudin-3", "gene_name": "Cldn3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSMGLEITGTSLAVLGWLCTIVCCALPMWRVSAFIGSSIITAQITWEGLWMNCVVQSTGQMQCKMYDSLLALPQDLQAARALIVVSILLAAFGLLVALVGAQCTNCVQDETAKAKITIVAGVLFLLAAVLTLVPVSWSANTIIRDFYNPLVPEAQKREMGTGLYVGWAAAALQLLGGALLCCSCPPREKYAPTKILYSAPRSTGPGTGTGTAYDRKDYV", "length": 219 }, "evidence": [ { "id": "Q765N9", "url": "https://omabrowser.org/oma/group/Q765N9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6DHP1-1", "protein_name": "Claudin-7-A", "gene_name": "cldn7a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MANSGVQLLGFGLSLIGIIGLIVGTILPQWKMSAYVGDSIITAVATYQGLWMSCAFQSTGQLQCKIYDSILQLDSDLQATRALMIVGIIVSIAGLGVASIGMKCTTCGADDKVRKTRTAMTGGIILLVGALCAVVACSWFAHNVIRAFYNPFTPVNTKFEFGAAIFIAWGGSFLDVLGGAMLAASCPRSKQVSKYPKSNSTRSANGSNKEYV", "length": 212 }, "evidence": [ { "id": "Q765N9", "url": "https://omabrowser.org/oma/group/Q765N9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9Z0G9-1", "protein_name": "Claudin-3", "gene_name": "Cldn3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSMGLEITGTSLAVLGWLCTIVCCALPMWRVSAFIGSSIITAQITWEGLWMNCVVQSTGQMQCKMYDSLLALPQDLQAARALIVVSILLAAFGLLVALVGAQCTNCVQDETAKAKITIVAGVLFLLAALLTLVPVSWSANTIIRDFYNPLVPEAQKREMGAGLYVGWAAAALQLLGGALLCCSCPPRDKYAPTKILYSAPRSTGPGTGTGTAYDRKDYV", "length": 219 }, "evidence": [ { "id": "Q765N9", "url": 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migration", "id": "GO:0030336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030336", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" }, { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" }, { "name": "positive regulation of wound healing", "id": "GO:0090303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090303", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" }, { "name": "bicellular tight junction assembly", "id": "GO:0070830", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070830", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" }, { "name": "epithelial cell morphogenesis", "id": "GO:0003382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003382", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" }, { "name": "regulation of cell morphogenesis", "id": "GO:0022604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022604", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" }, { "name": "retinal pigment epithelium development", "id": "GO:0003406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003406", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" }, { "name": "cell-cell junction maintenance", "id": "GO:0045217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045217", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" }, { "name": "calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules", "id": "GO:0016338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016338", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" }, { "name": "establishment of endothelial blood-brain barrier", "id": "GO:0014045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014045", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" }, { "name": "regulation of transepithelial transport", "id": "GO:0150111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150111", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" }, { "name": "negative regulation of phosphate transmembrane transport", "id": "GO:2000186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000186", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" }, { "name": "bicellular tight junction", "id": "GO:0005923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005923", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" }, { "name": "lateral plasma membrane", "id": "GO:0016328", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016328", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" }, { "name": "apicolateral plasma membrane", "id": "GO:0016327", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016327", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" }, { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" }, { "name": "cell-cell adhesion mediator activity", "id": "GO:0098632", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098632", "evidence": [ { "database": "UniProtKB", "id": "Q765N9", "url": "https://www.uniprot.org/uniprotkb/Q765N9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q765N9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 219, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q765N9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q765N9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 197, 198, 208 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q76BS1-1", "uniprot_ac": "Q76BS1", "uniprot_id": "HGF_BOVIN", "mass": { "chemical_mass": 83357.0, "monoisotopic_mass": 83357.0 }, "refseq": { "ac": "NP_001026921", "name": "hepatocyte growth factor precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026921" }, "gene_names": [ { "name": "HGF", "type": "recommended", "evidence": [ { "id": "Q76BS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76BS1" } ] }, { "name": "HGF", "type": "synonym", "evidence": [ { "id": "NP_001026921", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026921" } ] } ], "protein_names": [ { "name": "Hepatocyte growth factor", "type": "recommended", "evidence": [ { "id": "Q76BS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76BS1/entry#names_and_taxonomy" } ] }, { "name": "Hepatopoietin-A", "type": "synonym", "evidence": [ { "id": "Q76BS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76BS1/entry#names_and_taxonomy" } ] }, { "name": "SF", "type": "synonym", "evidence": [ { "id": "NP_001026921", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026921" }, { "id": "Q76BS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76BS1/entry#names_and_taxonomy" } ] }, { "name": "Scatter factor", "type": "synonym", "evidence": [ { "id": "Q76BS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76BS1/entry#names_and_taxonomy" } ] }, { "name": "hepapoietin A", "type": "synonym", "evidence": [ { "id": "NP_001026921", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026921" } ] }, { "name": "hepatocyte growth factor precursor", "type": "synonym", "evidence": [ { "id": "NP_001026921", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026921" } ] }, { "name": "hepatopoeitin-A", "type": "synonym", "evidence": [ { "id": "NP_001026921", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026921" } ] }, { "name": "hepatopoietin-A", "type": "synonym", "evidence": [ { "id": "NP_001026921", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026921" } ] }, { "name": "scatter factor", "type": "synonym", "evidence": [ { "id": "NP_001026921", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026921" } ] } ], "function": [ { "annotation": "HGF transiently increases gene transcription of angiotensin-converting enzyme", "evidence": [ { "database": "RefSeq", "id": "NP_001026921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026921" }, { "database": "PubMed", "id": "14679188", "url": "https://glygen.org/publication/PubMed/14679188" } ] }, { "annotation": "Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (By similarity). Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). Activates MAPK signaling following TMPRSS13 cleavage and activation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q76BS1", "url": "https://www.uniprot.org/uniprotkb/Q76BS1#function" }, { "database": "UniProtKB", "id": "P14210", "url": "https://www.uniprot.org/uniprotkb/P14210#function" } ] }, { "annotation": "Results confirm the prodevelopmental actions of activin A and indicate that CTGF may also function as an embryokine by regulating the number of ICM cells in the blastocyst and altering gene expression. Low concentrations of HGF were inhibitory to development.", "evidence": [ { "database": "RefSeq", "id": "NP_001026921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026921" }, { "database": "PubMed", "id": "27185102", "url": "https://glygen.org/publication/PubMed/27185102" } ] }, { "annotation": "SNPs within bovine HGF gene were significantly associated with growth traits. This will provide a background for application of bovine HGF gene in the selection program in Chinese cattle.", "evidence": [ { "database": "RefSeq", "id": "NP_001026921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026921" }, { "database": "PubMed", "id": "23632198", "url": "https://glygen.org/publication/PubMed/23632198" } ] }, { "annotation": "These results indicate that expression and production of HGF are regulated in a species-specific adipogenic differentiation-dependent manner and suggest that the decrease in HGF mRNA in mouse differentiated adipocytes is, at least in part, mediated by differentiation-dependent loss of its stability.", "evidence": [ { "database": "RefSeq", "id": "NP_001026921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026921" }, { "database": "PubMed", "id": "29040876", "url": "https://glygen.org/publication/PubMed/29040876" } ] }, { "annotation": "Treatment of the bovine satellite cells (BSC) with ephrin-A5 causes a reduction in velocity with a concomitant increase in directed migration. Treatment of BSC with hepatocyte growth factor had no immediate effect on cell motility or migration.", "evidence": [ { "database": "RefSeq", "id": "NP_001026921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026921" }, { "database": "PubMed", "id": "23296833", "url": "https://glygen.org/publication/PubMed/23296833" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q76BS1", "url": "https://www.uniprot.org/uniprotkb/Q76BS1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HGF", "url": "https://www.uniprot.org/uniprotkb/Q76BS1", "locus": { "chromosome": "4", "start_pos": 39010999, "end_pos": 38929386, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017664", "url": "https://www.ensembl.org/id/ENSBTAG00000017664" } ] } } ], "crossref": [ { "id": "Q76BS1", "url": "https://alphafold.ebi.ac.uk/entry/Q76BS1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00108", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00108", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00129", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00129", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282879", "url": "https://www.ncbi.nlm.nih.gov/gene/282879", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003609", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003609", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024174", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024174", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027284", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027284", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050759", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050759", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282879", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282879", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q76BS1", "url": "https://www.orthodb.org/?gene=Q76BS1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24261", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24261", "database": "PANTHER", "categories": [ "Protein 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"evidence": [ { "database": "RefSeq", "id": "NP_001026921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026921" } ], "reference": [ { "type": "PubMed", "id": "14679188", "url": "https://glygen.org/publication/PubMed/14679188" } ] }, { "title": "Bovine hepatocyte growth factor and its receptor c-Met: cDNA cloning and expression analysis in the mammary gland.", "journal": "Domest. Anim. Endocrinol.", "date": "2006", "authors": "Yamaji Daisuke, Kimura Kazuhiro, Watanabe Atsushi, Kon Yasuhiro, Iwanaga Toshihiko, Soliman Mohamed M, Ahmed Mohamed M, Saito Masayuki", "evidence": [ { "database": "UniProtKB", "id": "Q76BS1", "url": "https://www.uniprot.org/uniprotkb/Q76BS1" } ], "reference": [ { "type": "PubMed", "id": "16207523", "url": "https://glygen.org/publication/PubMed/16207523" } ] }, { "title": "Ephrin-A5 promotes bovine muscle progenitor cell migration before mitotic activation.", "journal": "Journal of animal science", "date": "2013-03", "authors": "Li J, Johnson S E", "evidence": [ { "database": "RefSeq", "id": "NP_001026921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026921" } ], "reference": [ { "type": "PubMed", "id": "23296833", "url": "https://glygen.org/publication/PubMed/23296833" } ] }, { "title": "SNPs of bovine HGF gene and their association with growth traits in Nanyang cattle.", "journal": "Research in veterinary science", "date": "2013-10", "authors": "Cai Hanfang, Lan Xianyong, Li Aimin, Zhou Yang, Sun Jiajie, Lei Chuzhao, Zhang Chunlei, Chen Hong", "evidence": [ { "database": "RefSeq", "id": "NP_001026921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026921" } ], "reference": [ { "type": "PubMed", "id": "23632198", "url": "https://glygen.org/publication/PubMed/23632198" } ] }, { "title": "Actions of activin A, connective tissue growth factor, hepatocyte growth factor and teratocarcinoma-derived growth factor 1 on the development of the bovine preimplantation embryo.", "journal": "Reproduction, fertility, and development", "date": "2017-07", "authors": "Kannampuzha-Francis Jasmine, Tribulo Paula, Hansen Peter J", "evidence": [ { "database": "RefSeq", "id": "NP_001026921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026921" } ], "reference": [ { "type": "PubMed", "id": "27185102", "url": "https://glygen.org/publication/PubMed/27185102" } ] }, { "title": "Species-specific control of hepatocyte growth factor 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However, ability to acetylate polyamines is weak, suggesting that it does not act as a diamine acetyltransferase in vivo.", "evidence": [ { "database": "UniProtKB", "id": "Q7PCJ8", "url": "https://www.uniprot.org/uniprotkb/Q7PCJ8#function" }, { "database": "UniProtKB", "id": "Q96F10", "url": "https://www.uniprot.org/uniprotkb/Q96F10#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q7PCJ8", "url": "https://www.uniprot.org/uniprotkb/Q7PCJ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SAT2", "url": "https://www.uniprot.org/uniprotkb/Q7PCJ8", "locus": { "chromosome": "19", "start_pos": 27342160, "end_pos": 27345975, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004222", "url": "https://www.ensembl.org/id/ENSBTAG00000004222" } ] } } ], "crossref": [ { "id": "Q7PCJ8", "url": "https://alphafold.ebi.ac.uk/entry/Q7PCJ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004222", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004222", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04301", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04301", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "359722", "url": "https://www.ncbi.nlm.nih.gov/gene/359722", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051016", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051016", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:359722", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:359722", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QSEWVRY", "url": "https://omabrowser.org/oma/group/QSEWVRY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q7PCJ8", "url": "https://www.orthodb.org/?gene=Q7PCJ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10545", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10545", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10545:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10545:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00583", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00583", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_976068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_976068", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11116", "url": "https://www.rhea-db.org/rhea/11116", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "64804", "url": "https://www.rhea-db.org/rhea/64804", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q7PCJ8", "url": "https://www.uniprot.org/uniprotkb/Q7PCJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7PCJ8-1", "url": "https://www.uniprot.org/uniprotkb/Q7PCJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFVMIREAKEGDCGNILRLIRELAEYEKLSDQVKISEEALRADGFGETPFYHCLVAEILSAPGEPQGPCVVGYGLYYFSYSTWKGRNIYLEDIYVKPEYRGQGIGSKIIKKVAEVALDKGCSQLRLAVLDWNKRAMDLYKALGAQDLTEAEGWHCFRFEGEAMRELAGK", "length": 170, "header": "sp|Q7PCJ8-1|SAT2_BOVIN Isoform 1 of Thialysine N-epsilon-acetyltransferase OS=Bos taurus OX=9913 GN=SAT2 PE=2 SV=1 CANONICAL=Q7PCJ8-1" }, "isoforms": [ { "isoform_ac": "Q7PCJ8-1", "url": "https://www.uniprot.org/uniprotkb/Q7PCJ8/entry#Q7PCJ8-1", "sequence": { "sequence": "MAFVMIREAKEGDCGNILRLIRELAEYEKLSDQVKISEEALRADGFGETPFYHCLVAEILSAPGEPQGPCVVGYGLYYFSYSTWKGRNIYLEDIYVKPEYRGQGIGSKIIKKVAEVALDKGCSQLRLAVLDWNKRAMDLYKALGAQDLTEAEGWHCFRFEGEAMRELAGK", "length": 170, "header": "sp|Q7PCJ8-1|SAT2_BOVIN Isoform 1 of Thialysine N-epsilon-acetyltransferase OS=Bos taurus OX=9913 GN=SAT2 PE=2 SV=1 CANONICAL=Q7PCJ8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase.", "journal": "Biochem. J.", "date": "2003", "authors": "Chen Ying, Vujcic Slavoljub, Liang Ping, Diegelman Paula, Kramer Debora L, Porter Carl W", "evidence": [ { "database": "UniProtKB", "id": "Q7PCJ8", "url": "https://www.uniprot.org/uniprotkb/Q7PCJ8" } ], "reference": [ { "type": "PubMed", "id": "12803540", "url": "https://glygen.org/publication/PubMed/12803540" } ] } ], "pathway": [ { "id": "bta:359722", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:359722", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6P8J2-1", "protein_name": "Thialysine N-epsilon-acetyltransferase", "gene_name": "Sat2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASTRIREARESDCGDIMRMIRELAEFEKLSHQVKISEEALRADGFGENPFFHCLVAEIIPAPGESQGSLVVGYGLYYFIYSTWTGRNVYLEDIYVMPQYRGQGIGTKIIKKVAEVALNKGCSQFRLAVLDWNKKAVNLYKFLGAQDLTESEGWLSFRFEGEAMRELAGR", "length": 170 }, "evidence": [ { "id": "Q7PCJ8", "url": "https://omabrowser.org/oma/group/Q7PCJ8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7PCJ9-1", "protein_name": "Thialysine N-epsilon-acetyltransferase", "gene_name": "SAT2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASVLIREAKEGDCGNILRMIRELAEYEKLSDQVKISEEALRADGFGENPFFHCLVAEILPAPGEPQGSCMVGYGLYYFIYSTWTGRNIYLEDIYVKPEYRGQGIGSKIIKKVAEVALDKGCSQFRLAVLDWNKKAVDLYKTLGARDLTEAEGWHSFRFEGEAMRELAGK", "length": 170 }, "evidence": [ { "id": "Q7PCJ8", "url": "https://omabrowser.org/oma/group/Q7PCJ8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q96F10-1", "protein_name": "Thialysine N-epsilon-acetyltransferase", "gene_name": "SAT2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASVRIREAKEGDCGDILRLIRELAEFEKLSDQVKISEEALRADGFGDNPFYHCLVAEILPAPGKLLGPCVVGYGIYYFIYSTWKGRTIYLEDIYVMPEYRGQGIGSKIIKKVAEVALDKGCSQFRLAVLDWNQRAMDLYKALGAQDLTEAEGWHFFCFQGEATRKLAGK", "length": 170 }, "evidence": [ { "id": "Q7PCJ8", "url": "https://omabrowser.org/oma/group/Q7PCJ8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9ZV06-1", "protein_name": "GCN5-related N-acetyltransferase 8", "gene_name": "GNAT8", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAAAAPPPPPTAAPEPNMVAPLISPIGHPMFSRIRLATPSDVPFIHKLIHQMAVFERLTHLFSATESGLASTLFTSRPFQSFTVFLLEVSRSPFPATITSSPSPDFTPFFKTHNLDLPIDDPESYNFSPDMLNDVVVAGFVLFFPNYSSFLSKPGFYIEDIFVREPYRRKGFGSMLLTAVAKQAVKMGYGRVEWVVLDWNVNAIKFYEQMGAQILQEWRVCRLTGDALEAFDQVNI", "length": 236 }, "evidence": [ { "id": "Q7PCJ8", "url": "https://omabrowser.org/oma/group/Q7PCJ8/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q7PCJ8", "url": "https://www.uniprot.org/uniprotkb/Q7PCJ8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "N-acetyltransferase activity", "id": "GO:0008080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008080", "evidence": [ { "database": "UniProtKB", "id": "Q7PCJ8", "url": "https://www.uniprot.org/uniprotkb/Q7PCJ8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "polyamine metabolic process", "id": "GO:0006595", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006595", "evidence": [ { "database": "UniProtKB", "id": "Q7PCJ8", "url": "https://www.uniprot.org/uniprotkb/Q7PCJ8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11116", "name": "", "equation": "an alkane-alpha,omega-diamine + acetyl-CoA = an N-acetylalkane-alpha,omega-diamine + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3T0Q0-1", "Q7PCJ8-1" ], "evidence": [ { "id": "11116", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11116" } ] }, { "id": "64804", "name": "", "equation": "S-(2-aminoethyl)-L-cysteine + acetyl-CoA = S-(2-acetamidoethyl)-L-cysteine + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q7PCJ8-1" ], "evidence": [ { "id": "64804", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/64804" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q3T0Q0", "gene_name": "SAT1", "activity": [ { "ec_number": "2.3.1.57", "activity": "an alkane-alpha,omega-diamine + acetyl-CoA = an N-acetylalkane-alpha,omega-diamine + CoA + H(+).", "evidence": [ { "id": "Q3T0Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q0" } ] }, { "ec_number": "2.3.1.57", "activity": "", "evidence": [ { "id": "Q3T0Q0", "database": 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Potently inhibits angiogenesis and tumor growth (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q7SIB3", "url": "https://www.uniprot.org/uniprotkb/Q7SIB3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q7SIB3", "url": "https://www.uniprot.org/uniprotkb/Q7SIB3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COL4A2", "url": "https://www.uniprot.org/uniprotkb/Q7SIB3", "locus": { "chromosome": "12", "start_pos": 85154242, "end_pos": 84995988, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025210", "url": "https://www.ensembl.org/id/ENSBTAG00000025210" } ] } } ], "crossref": [ { "id": "Q7SIB3", "url": "https://alphafold.ebi.ac.uk/entry/Q7SIB3", "database": "AlphaFoldDB", "categories": [] }, { "id": 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Biol.", "date": "2006", "authors": "Mears Jason A, Sharma Manjuli R, Gutell Robin R, McCook Amanda S, Richardson Paul E, Caulfield Thomas R, Agrawal Rajendra K, Harvey Stephen C", "evidence": [ { "database": "UniProtKB", "id": "Q7YR75", "url": "https://www.uniprot.org/uniprotkb/Q7YR75" } ], "reference": [ { "type": "PubMed", "id": "16510155", "url": "https://glygen.org/publication/PubMed/16510155" } ] } ], "pathway": [ { "id": "bta:399560", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:399560", "resource": "KEGG Pathway" }, { "id": "R-BTA-5389840", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-9837999", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9837999", "resource": "Reactome", "description": "Mitochondrial protein degradation" }, { "id": "R-BTA-9937383", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "resource": "Reactome", "description": "Mitochondrial ribosome-associated quality control" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1U6S6-1", "protein_name": "Large ribosomal subunit protein bL12m", "gene_name": "MRPL12", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLPAAASSLWGPCFGLRAAALRVARHQGPRLCGVRLMRCSSHRKGEALAGAPLDNAPKEYPPKIQQLVQDIASLTLLEISDLNELLKKTLKIQDVGFMPMGAVAPGAPPAAAAPEAAEEDLPKRKEQTHFTVRLTEAKPVDKVKLIKEIKSHIQGINLVQAKKLVESLPQEIKANVPKAEAEKIKAALEAVGGTVVLE", "length": 198 }, "evidence": [ { "id": "Q7YR75", "url": "https://omabrowser.org/oma/group/Q7YR75/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V1ALS2-1", "protein_name": "Large ribosomal subunit protein bL12m", "gene_name": "MRPL12", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLPAARLALPLPPRLARRPPLSWRWGAARPLGTGRARRRSEALAGEALAGAPLDTAAKEYSPKVRQLVRDIAGLTLLEVADLNALLKETLKIPDVGVMPAGAAAHLPAQAAPQEEEEAIPMKKEKTHFSVRLTELKATDKVKLIKEVKNFVPGINLVQAKKLVESLPQEIKANVSKEEAEKIKTALEAAGGTVVLE", "length": 196 }, "evidence": [ { "id": "Q7YR75", "url": "https://omabrowser.org/oma/group/Q7YR75/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P36210-1", "protein_name": "Large ribosomal subunit protein bL12cz", "gene_name": "RPL12A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MASTTLSIATTIRSSSYPTLASINHFPSRTTTIEFPSRFGGGSSSTLTHRATHLRPIAAVEAPEKIEKIGSEISSLTLEEARILVDYLQDKFGVSPLSLAPAAAAVAAPADGGAAAVVEEQTEFDVVINEVPSSSRIAVIKAVRALTSLALKEAKELIEGLPKKFKEGITKDEAEEAKKTLEEAGAKVSIA", "length": 191 }, "evidence": [ { "id": "Q7YR75", "url": "https://omabrowser.org/oma/group/Q7YR75/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P52815-1", "protein_name": "Large ribosomal subunit protein bL12m", "gene_name": "MRPL12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLPAAARPLWGPCLGLRAAAFRLARRQVPCVCAVRHMRSSGHQRCEALAGAPLDNAPKEYPPKIQQLVQDIASLTLLEISDLNELLKKTLKIQDVGLVPMGGVMSGAVPAAAAQEAVEEDIPIAKERTHFTVRLTEAKPVDKVKLIKEIKNYIQGINLVQAKKLVESLPQEIKANVAKAEAEKIKAALEAVGGTVVLE", "length": 198 }, "evidence": [ { "id": "Q7YR75", "url": "https://omabrowser.org/oma/group/Q7YR75/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P53163-1", "protein_name": "Large ribosomal subunit protein bL12m", "gene_name": "MNP1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSLRILAKRSSSIWMKTRVTPALISPITITTRFNSTTTTAPSHKDDVRPVDPKISKIVQDISQLTLLETSSLINELKTVLNIPEISMPMGGFMAGAAGAGAGNVPSSTGEAGSGAEEEAKPEAKTVFTVKLDSFDTKTKAKVIKEVKGLLGLSLVEAKKFVEAAPKVLKENVAKDDAEKIKKTLEDLGAKVSLE", "length": 194 }, "evidence": [ { "id": "Q7YR75", "url": "https://omabrowser.org/oma/group/Q7YR75/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q86KA1-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MISRVSLNKCFSTLSKLKCNNNTLYSTRLFTTEPEKVNLKLTTIENGKSSTEVADLVERISKLSILDVMDLTQHLQKKLSIPDIDLSSLGSGAPAGGAAPAAAAAPAAVAKTDFQVRLVKVPDGAKYKIIKELREVKPSLSLMETKGLVEKIPSVIADKVSKEEAEKIIAKLKASGAELEMA", "length": 182 }, "evidence": [ { "id": "Q7YR75", "url": "https://omabrowser.org/oma/group/Q7YR75/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9DB15-1", "protein_name": "Large ribosomal subunit protein bL12m", "gene_name": "Mrpl12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPVAASRCLWGPRLGLRGAALRLARQQMPSVCAARQLRSSSHRRSEALAGAPLDNAPKEYPPKIQQLVQDIASLTLLEISDLNELLKKTLKIQDVGLMPMGGMVPGPVSAAAPASEAAEEEDVPKQKERTHFTVRLTEAKPVDKVKLIKEIKNYVQGINLVQAKKLVESLPQEIKANVAKAEAEKIKAALEAVGGTVVLE", "length": 201 }, "evidence": [ { "id": "Q7YR75", "url": "https://omabrowser.org/oma/group/Q7YR75/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VSR5-1", "protein_name": "Mitochondrial ribosomal protein L12", "gene_name": "mRpL12", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MHITRLALRQISRQVQLHRMYSAAAPAAAVSGAEKLVPPAPEGAAKPPNPKLDSIVNNIAALNLLEVAELSTLLKQKLNLPETAFAPQFAAGPARAAPAEDEEEAAPKKVQTSFKVKLVKFDEKQKVALIKEVKNLLEGMNLVQAKKFVESAPTIVKEDIPKEEAEKLKEALSKAGAIIEIE", "length": 182 }, "evidence": [ { "id": "Q7YR75", "url": "https://omabrowser.org/oma/group/Q7YR75/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "X1WHQ5-1", "protein_name": "Large ribosomal subunit protein bL12m", "gene_name": "mrpl12", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMYCSRHCVRLALRAAVNTHRHSVQRTALYAQRTLKTSSVSAVDAIATPHLDGTPKEYSPKIQQLVNDIASLTLIEVSDLNELLKKTLNIQDVGMMSMGSMAAVPVAPPAELTEGLAEEEVAPAKKEKTHFTIKLTEFKAADKVKLIKEVKNCMEGINLVQAKKLVESLPQEIRTNISKDEAEKLKSALEAAGGTVVLE", "length": 199 }, "evidence": [ { "id": "Q7YR75", "url": "https://omabrowser.org/oma/group/Q7YR75/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial large ribosomal subunit", "id": "GO:0005762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005762", "evidence": [ { "database": "UniProtKB", "id": "Q7YR75", "url": "https://www.uniprot.org/uniprotkb/Q7YR75" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q7YR75", "url": "https://www.uniprot.org/uniprotkb/Q7YR75" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "Q7YR75", "url": "https://www.uniprot.org/uniprotkb/Q7YR75" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "Q7YR75", "url": "https://www.uniprot.org/uniprotkb/Q7YR75" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "Q7YR75", "url": "https://www.uniprot.org/uniprotkb/Q7YR75" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "Q7YR75", "url": "https://www.uniprot.org/uniprotkb/Q7YR75" } ], "pmid": "" }, { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "Q7YR75", "url": "https://www.uniprot.org/uniprotkb/Q7YR75" } ], "pmid": "" }, { "name": "mitochondrial transcription", "id": "GO:0006390", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006390", "evidence": [ { "database": "UniProtKB", "id": "Q7YR75", "url": "https://www.uniprot.org/uniprotkb/Q7YR75" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q7YR75-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 198, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q7YR75-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q7YR75" }, { "pdb_id": "2ftc", "pdb_chain": "e/f", "start_pos": 62, "end_pos": 198, "overlap": "1.0", "method": "Electron_Microscopy", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/2ftc.pdb", "url_external": "https://www.rcsb.org/structure/2ftc" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 112 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q7YRC1-1", "uniprot_ac": "Q7YRC1", "uniprot_id": "AIP_BOVIN", "mass": { "chemical_mass": 37565.0, "monoisotopic_mass": 37565.0 }, "refseq": {}, "gene_names": [ { "name": "AIP", "type": "recommended", "evidence": [ { "id": "Q7YRC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC1" } ] } ], "protein_names": [ { "name": "AH receptor-interacting protein", "type": "recommended", "evidence": [ { "id": "Q7YRC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC1/entry#names_and_taxonomy" } ] }, { "name": "AIP", "type": "synonym", "evidence": [ { "id": "Q7YRC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC1/entry#names_and_taxonomy" } ] }, { "name": "Aryl-hydrocarbon receptor-interacting protein", "type": "synonym", "evidence": [ { "id": "Q7YRC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.", "evidence": [ { "database": "UniProtKB", "id": "Q7YRC1", "url": "https://www.uniprot.org/uniprotkb/Q7YRC1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q7YRC1", "url": "https://www.uniprot.org/uniprotkb/Q7YRC1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AIP", "url": "https://www.uniprot.org/uniprotkb/Q7YRC1", "locus": { "chromosome": "29", "start_pos": 45373001, "end_pos": 45366926, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010478", "url": "https://www.ensembl.org/id/ENSBTAG00000010478" } ] } } ], "crossref": [ { "id": "IPR001179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039663", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039663", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056277", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056277", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "Q7YRC1", "url": "https://www.orthodb.org/?gene=Q7YRC1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11242", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11242", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11242:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11242:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF23322", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23322", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q7YRC1", "url": "https://www.uniprot.org/uniprotkb/Q7YRC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7YRC1-1", "url": "https://www.uniprot.org/uniprotkb/Q7YRC1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADIIARLREDGIQKRVIQEGRGALPDFQDGTKATFHYRTLCSDEEGAVLDDSRVRGKPMELIIGKKFKLPVWETIVRTMREGEIAQFCCDXKHVVLYPLVAKSLRNIAAGKDPLEGQRHCCGIAQMHXHSSLGHADLDALQQNPQPLIFDIEMLKVENPGTYQQDPWAMTDEEKAKAVPVIHQEGNRLYREGHVKEAAAKYYDAIACLKNLQMKEQPGSPDWIQLDQQITPLLLNYCQCKLVAEEYYEVLDHCSSILNKYDDNVKAYFKRGKAHAAVWNAQQAQDDFAKVLQLDPAMAPVVSRELRALEARIRQKDEEDKARFRGIFSH", "length": 330, "header": "sp|Q7YRC1-1|AIP_BOVIN Isoform 1 of AH receptor-interacting protein OS=Bos taurus OX=9913 GN=AIP PE=2 SV=1 CANONICAL=Q7YRC1-1" }, "isoforms": [ { "isoform_ac": "Q7YRC1-1", "url": "https://www.uniprot.org/uniprotkb/Q7YRC1/entry#Q7YRC1-1", "sequence": { "sequence": "MADIIARLREDGIQKRVIQEGRGALPDFQDGTKATFHYRTLCSDEEGAVLDDSRVRGKPMELIIGKKFKLPVWETIVRTMREGEIAQFCCDXKHVVLYPLVAKSLRNIAAGKDPLEGQRHCCGIAQMHXHSSLGHADLDALQQNPQPLIFDIEMLKVENPGTYQQDPWAMTDEEKAKAVPVIHQEGNRLYREGHVKEAAAKYYDAIACLKNLQMKEQPGSPDWIQLDQQITPLLLNYCQCKLVAEEYYEVLDHCSSILNKYDDNVKAYFKRGKAHAAVWNAQQAQDDFAKVLQLDPAMAPVVSRELRALEARIRQKDEEDKARFRGIFSH", "length": 330, "header": "sp|Q7YRC1-1|AIP_BOVIN Isoform 1 of AH receptor-interacting protein OS=Bos taurus OX=9913 GN=AIP PE=2 SV=1 CANONICAL=Q7YRC1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 43, "end_pos": 43, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q7YRC1", "url": "https://www.uniprot.org/uniprotkb/Q7YRC1" } ], "site_lbl": "Ser43" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q7YRC1", "url": "https://www.uniprot.org/uniprotkb/Q7YRC1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "xenobiotic metabolic process", "id": "GO:0006805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805", "evidence": [ { "database": "UniProtKB", "id": "Q7YRC1", "url": "https://www.uniprot.org/uniprotkb/Q7YRC1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "Q7YRC1", "url": "https://www.uniprot.org/uniprotkb/Q7YRC1" } ], "pmid": "" }, { "name": "peptidyl-prolyl cis-trans isomerase activity", "id": "GO:0003755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003755", "evidence": [ { "database": "UniProtKB", "id": "Q7YRC1", "url": "https://www.uniprot.org/uniprotkb/Q7YRC1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q7YRC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC1" }, { "id": "PRU00277", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00277" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PPIase FKBP-type", "eco_id": "ECO_0000255", "start_pos": 54, "end_pos": 146, "start_aa": "Arg", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 43 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q7YRQ8-1", "uniprot_ac": "Q7YRQ8", "uniprot_id": "TFPI2_BOVIN", "mass": { "chemical_mass": 26675.0, "monoisotopic_mass": 26675.0 }, "refseq": { "ac": "NP_877589", "name": "tissue factor pathway inhibitor 2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_877589" }, "gene_names": [ { "name": "TFPI2", "type": "recommended", "evidence": [ { "id": "Q7YRQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRQ8" } ] }, { "name": "TFPI2", "type": "synonym", "evidence": [ { "id": "NP_877589", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_877589" } ] } ], "protein_names": [ { "name": "Tissue factor pathway inhibitor 2", "type": "recommended", "evidence": [ { "id": "Q7YRQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRQ8/entry#names_and_taxonomy" } ] }, { "name": "TFPI-2", "type": "synonym", "evidence": [ { "id": "NP_877589", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_877589" }, { "id": "Q7YRQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRQ8/entry#names_and_taxonomy" } ] }, { "name": "tissue factor pathway inhibitor 2 precursor", "type": "synonym", "evidence": [ { "id": "NP_877589", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_877589" } ] } ], "function": [ { "annotation": "Bovine TFPI2 was cloned and its expression and characterization determined.", "evidence": [ { "database": "RefSeq", "id": "NP_877589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_877589" }, { "database": "PubMed", "id": "12921785", "url": "https://glygen.org/publication/PubMed/12921785" } ] }, { "annotation": "May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.", "evidence": [ { "database": "UniProtKB", "id": "Q7YRQ8", "url": "https://www.uniprot.org/uniprotkb/Q7YRQ8#function" }, { "database": "PubMed", "id": "12921785", "url": "https://glygen.org/publication/PubMed/12921785" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q7YRQ8", "url": "https://www.uniprot.org/uniprotkb/Q7YRQ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TFPI2", "url": "https://www.uniprot.org/uniprotkb/Q7YRQ8", "locus": { "chromosome": "4", "start_pos": 11204089, "end_pos": 11208397, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015844", "url": "https://www.ensembl.org/id/ENSBTAG00000015844" } ] } } ], "crossref": [ { "id": "Q7YRQ8", "url": "https://alphafold.ebi.ac.uk/entry/Q7YRQ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015844", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015844", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22615", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22615", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22616", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22616", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "360007", "url": "https://www.ncbi.nlm.nih.gov/gene/360007", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002223", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002223", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008296", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008296", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020901", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020901", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036880", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036880", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:360007", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:360007", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "REEYFFN", "url": "https://omabrowser.org/oma/group/REEYFFN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q7YRQ8", "url": "https://www.orthodb.org/?gene=Q7YRQ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10083", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10083", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00014", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00014", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_877589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_877589", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q7YRQ8", "url": "https://www.uniprot.org/uniprotkb/Q7YRQ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7YRQ8-1", "url": "https://www.uniprot.org/uniprotkb/Q7YRQ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSVRPLWLMLLSLLLVGTALGDASQAPPGNNAEICLLPPDDGPCRARIPSYYYDRYTQSCREFMYGGCEGNANNFETLEACNEACWKIEKVPKICRLKVNKKQCGELREQYFFNLSSMTCKKFISGGCHSNENRFPDEATCMDFCAPKRAPVFCYSPKDEGLCSANVTRYYFNPRHKACEAFNYTGCGGNDNNFVNLKDCKRTCVKALKKEKNKKMPRLLLANRRLKIKKKQF", "length": 234, "header": "sp|Q7YRQ8-1|TFPI2_BOVIN Isoform 1 of Tissue factor pathway inhibitor 2 OS=Bos taurus OX=9913 GN=TFPI2 PE=2 SV=1 CANONICAL=Q7YRQ8-1" }, "isoforms": [ { "isoform_ac": "Q7YRQ8-1", "url": "https://www.uniprot.org/uniprotkb/Q7YRQ8/entry#Q7YRQ8-1", "sequence": { "sequence": "MDSVRPLWLMLLSLLLVGTALGDASQAPPGNNAEICLLPPDDGPCRARIPSYYYDRYTQSCREFMYGGCEGNANNFETLEACNEACWKIEKVPKICRLKVNKKQCGELREQYFFNLSSMTCKKFISGGCHSNENRFPDEATCMDFCAPKRAPVFCYSPKDEGLCSANVTRYYFNPRHKACEAFNYTGCGGNDNNFVNLKDCKRTCVKALKKEKNKKMPRLLLANRRLKIKKKQF", "length": 234, "header": "sp|Q7YRQ8-1|TFPI2_BOVIN Isoform 1 of Tissue factor pathway inhibitor 2 OS=Bos taurus OX=9913 GN=TFPI2 PE=2 SV=1 CANONICAL=Q7YRQ8-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 115, "start_aa": "Asn", "end_pos": 115, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn115", "evidence": [ { "id": "Q7YRQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRQ8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 167, "start_aa": "Asn", "end_pos": 167, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn167", "evidence": [ { "id": "Q7YRQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRQ8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "Q7YRQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRQ8#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Molecular cloning, expression, and characterization of bovine tissue factor pathway inhibitor-2.", "journal": "Archives of biochemistry and biophysics", "date": "2003", "authors": "Du X, Deng FM, Chand HS, Kisiel W", "evidence": [ { "database": "UniProtKB", "id": "Q7YRQ8", "url": "https://www.uniprot.org/uniprotkb/Q7YRQ8" }, { "database": "RefSeq", "id": "NP_877589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_877589" } ], "reference": [ { "type": "PubMed", "id": "12921785", "url": "https://glygen.org/publication/PubMed/12921785" } ] } ], "pathway": [ { "id": "bta:360007", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:360007", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q3A7D8-1", "protein_name": "Tissue factor pathway inhibitor", "gene_name": "TFPI2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAGRRLPLPALLLPLACAALAPRGLTEKQRACLLPPDDGPCRALVPRWYYDRYTQSCQEFSYGGCHGNANNFLSHDDCEKNCWTIKKVPKLCRMEADTGPCRGYIRRYAFNLSSMRCEEFIYGGCYGNGNNFKDLQSCVDHCLPEKTGPLLCYSPKDEGLCSSSVPRYYYDTTSKSCKEFKYTGCGGNANNFVTEVDCYNVCRKAGSQKPTINKSRSLLRRKMMRKLIKKPQTHNPKS", "length": 239 }, "evidence": [ { "id": "Q7YRQ8", "url": "https://omabrowser.org/oma/group/Q7YRQ8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A4X1U3A3-1", "protein_name": "Tissue factor pathway inhibitor", "gene_name": "TFPI2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNSVRTHGLVLLPLLLVGTALGDAPRASPGNYSEICLLPPDEGPCRALVPSYYYDRYTQSCREFMYGGCEGNANNFETWEACDEACWRIEKVPKICRLEVSKRQCGELREEYFFNLSSMTCEKFLSGGCHGNANRFLDEATCMGFCAPKKSPSFCYSPKDEGLCSANVTRYYFNPRHKACETFTYTGCGGNDNNFVSMKDCKRACVKALKKEKKMPRLLLASRRLKIKKKQF", "length": 232 }, "evidence": [ { "id": "Q7YRQ8", "url": "https://omabrowser.org/oma/group/Q7YRQ8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3V7D5-1", "protein_name": "Tissue factor pathway inhibitor 2", "gene_name": "Tfpi2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "RPLFWEQTTSTLLPLSAHPGSRTTRSYGPCYIPETVESAAAPGGFSSWSRFSICPRDQKKCRRFKYGGCLGNANNFHSRKLCEHTCGNKEKVPWVCRSAVRTYPCDKPNTEFFFNLKTMTCEPLRPGLCSRTTNVFPEEAMCKSLCEPRKSIPSFCSSPKDEGLCSANVTRYYFNSRNKACETFTYTGCGGNENNFYYLDACNRACVKALKKPKRRKIGDFLPRFWKLRS", "length": 230 }, "evidence": [ { "id": "Q7YRQ8", "url": "https://omabrowser.org/oma/group/Q7YRQ8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O35536-1", "protein_name": "Tissue factor pathway inhibitor 2", "gene_name": "Tfpi2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDPAMPLQLWNLPLLLVGSVLGLTSVSAQGNNLEICLLPLDAGPCQALIPKFYYDRDQQKCRRFNYGGCLGNANNFHSRDLCQQTCGSIEKVPPVCRSELKTYPCDKPNIRFFFNLNTMTCEPLRPGLCSRTINVFSEEATCKGLCEPRKHIPSFCSSPKDEGLCSANVTRFYFNSRNKTCETFTYTGCGGNENNFYYLDACHRACVKGWKKPKRWKIGDFLPRFWKHLS", "length": 230 }, "evidence": [ { "id": "Q7YRQ8", "url": "https://omabrowser.org/oma/group/Q7YRQ8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P48307-1", "protein_name": "Tissue factor pathway inhibitor 2", "gene_name": "TFPI2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDPARPLGLSILLLFLTEAALGDAAQEPTGNNAEICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNANNFYTWEACDDACWRIEKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTCEKFFSGGCHRNRIENRFPDEATCMGFCAPKKIPSFCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAKALKKKKKMPKLRFASRIRKIRKKQF", "length": 235 }, "evidence": [ { "id": "Q7YRQ8", "url": "https://omabrowser.org/oma/group/Q7YRQ8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } 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"RAB17", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1N7V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7V2" } ] } ] }, { "uniprot_ac": "F2Z4D5", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F2Z4D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F2Z4D5" } ] } ] }, { "uniprot_ac": "F6Q1G9", "gene_name": "RAB24", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "F6Q1G9", "database": "UniProtKB", "url": 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phosphate + H(+).", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "P62833", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] } ] }, { "uniprot_ac": "P62998", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62998" } ] } ] }, { "uniprot_ac": "P63097", "gene_name": "GNAI1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P63097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63097" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P81947", "gene_name": "", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81947" } ] } ] }, { "uniprot_ac": "P81948", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P81948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P81948" } ] } ] }, { "uniprot_ac": "P82922", "gene_name": "DAP3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P82922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P82922" } ] } ] }, { "uniprot_ac": "P84080", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": 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phosphate + H(+).", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DI5" } ] } ] }, { "uniprot_ac": "Q08E00", "gene_name": "RASL12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q08E00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E00" } ] } ] }, { "uniprot_ac": "Q0IIG7", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG7" } ] } ] }, { "uniprot_ac": "Q0IIG8", "gene_name": "RAB18", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0IIG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIG8" } ] } ] }, { "uniprot_ac": "Q0P5E2", "gene_name": "GPN3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q0P5E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5E2" } ] } ] }, { "uniprot_ac": "Q0VCJ7", "gene_name": "RERG", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q0VCJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCJ7" } ] } ] }, { "uniprot_ac": "Q17QB7", "gene_name": "RAB30", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB7" } ] } ] }, { "uniprot_ac": "Q17QI8", "gene_name": "Rhov", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI8" } ] } ] }, { "uniprot_ac": "Q17QU4", "gene_name": "RAB39B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17QU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QU4" } ] } ] }, { "uniprot_ac": "Q17R06", "gene_name": "RAB21", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q17R06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R06" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q862A9-1", "uniprot_ac": "Q862A9", "uniprot_id": "GPBAR_BOVIN", "mass": { "chemical_mass": 35104.0, "monoisotopic_mass": 35104.0 }, "refseq": { "ac": "NP_778219", "name": "G-protein coupled bile acid receptor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778219" }, "gene_names": [ { "name": "GPBAR1", "type": "recommended", "evidence": [ { "id": "Q862A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q862A9" } ] }, { "name": "GPBAR1", "type": "synonym", "evidence": [ { "id": "NP_778219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778219" } ] }, { "name": "TGR5", "type": "synonym", "evidence": [ { "id": "NP_778219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778219" }, { "id": "Q862A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q862A9" } ] } ], "protein_names": [ { "name": "G protein-coupled bile acid receptor 1", "type": "recommended", "evidence": [ { "id": "Q862A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q862A9/entry#names_and_taxonomy" } ] }, { "name": "G protein-coupled receptor TGR5", "type": "synonym", "evidence": [ { "id": "NP_778219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778219" } ] }, { "name": "G-protein coupled bile acid receptor 1", "type": "synonym", "evidence": [ { "id": "NP_778219", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778219" } ] } ], "function": [ { "annotation": "G protein-coupled receptor for bile acid. Bile acid-binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. GPBAR1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (By similarity). Activated by bile acids, such as lithocholate, deoxycholate, chenodeoxycholate and cholate, in descending order. Apart from their role in lipid dietary absorption and cholesterol catabolism, bile acids act as an important signaling molecule, involved in processes, such as energy expenditure or tissue inflammation (By similarity). GPBAR1-mediated signaling promotes energy expenditure and adiposity reduction in brown adipose tissue by activating adenylate cyclase, leading to DIO2 activation. Involved in bile acid promoted GLP-1 secretion (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q862A9", "url": "https://www.uniprot.org/uniprotkb/Q862A9#function" }, { "database": "UniProtKB", "id": "Q8TDU6", "url": "https://www.uniprot.org/uniprotkb/Q8TDU6#function" }, { "database": "UniProtKB", "id": "Q80SS6", "url": "https://www.uniprot.org/uniprotkb/Q80SS6#function" } ] }, { "annotation": "TGR5 agonism induces NO production via Akt activation and intracellular Ca(2+) increase in vascular endothelial cells, and this function inhibits monocyte adhesion in response to inflammatory stimuli.", "evidence": [ { "database": "RefSeq", "id": "NP_778219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778219" }, { "database": "PubMed", "id": "23619297", "url": "https://glygen.org/publication/PubMed/23619297" } ] }, { "annotation": "The bile acid receptor TGR5 inhibits platelet activation and thrombus formation.", "evidence": [ { "database": "RefSeq", "id": "NP_778219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778219" }, { "database": "PubMed", "id": "38968449", "url": "https://glygen.org/publication/PubMed/38968449" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q862A9", "url": "https://www.uniprot.org/uniprotkb/Q862A9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPBAR1", "url": "https://www.uniprot.org/uniprotkb/Q862A9", "locus": { "chromosome": "2", "start_pos": 106296627, "end_pos": 106289862, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003923", "url": "https://www.ensembl.org/id/ENSBTAG00000003923" } ] } } ], "crossref": [ { "id": "Q862A9", "url": "https://alphafold.ebi.ac.uk/entry/Q862A9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003923", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003923", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "317756", "url": "https://www.ncbi.nlm.nih.gov/gene/317756", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:317756", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:317756", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ACWVPYL", "url": "https://omabrowser.org/oma/group/ACWVPYL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q862A9", "url": "https://www.orthodb.org/?gene=Q862A9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24246", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24246", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24246:SF31", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24246:SF31", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-373076", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373076", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_778219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778219", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q862A9", "url": "https://www.uniprot.org/uniprotkb/Q862A9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q862A9-1", "url": "https://www.uniprot.org/uniprotkb/Q862A9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSNSTREVPSPVPAGALGLSLALASLIVAANLLLAVGIAGDRRLRSPPAGCFFLSLLLAGLLTGLALPALPVLWSQSRRGYWSCLFLYLAPNFCFLSLLANLLLVHGERYMAVLRPLRPRGSMRLALLLTWAAPLLFASLPALGWNHWAPGGNCSSQAVFPAPYLYLEIYGLLLPAVGAAALLSVRVLVTAHRQLQDIRRLERAVCRGAPSALARALTWRQARAQAGATLLFGLCWGPYVATLLLSVLAFEQRPPLGPGTLLSLISLGSASAAAVPVAMGLGDQRYTGPWRVAAQKWLRMLRGRPQSSPGPSTAYHTSSQSSVDLDLN", "length": 329, "header": "sp|Q862A9-1|GPBAR_BOVIN Isoform 1 of G protein-coupled bile acid receptor 1 OS=Bos taurus OX=9913 GN=GPBAR1 PE=2 SV=1 CANONICAL=Q862A9-1" }, "isoforms": [ { "isoform_ac": "Q862A9-1", "url": "https://www.uniprot.org/uniprotkb/Q862A9/entry#Q862A9-1", "sequence": { "sequence": "MTSNSTREVPSPVPAGALGLSLALASLIVAANLLLAVGIAGDRRLRSPPAGCFFLSLLLAGLLTGLALPALPVLWSQSRRGYWSCLFLYLAPNFCFLSLLANLLLVHGERYMAVLRPLRPRGSMRLALLLTWAAPLLFASLPALGWNHWAPGGNCSSQAVFPAPYLYLEIYGLLLPAVGAAALLSVRVLVTAHRQLQDIRRLERAVCRGAPSALARALTWRQARAQAGATLLFGLCWGPYVATLLLSVLAFEQRPPLGPGTLLSLISLGSASAAAVPVAMGLGDQRYTGPWRVAAQKWLRMLRGRPQSSPGPSTAYHTSSQSSVDLDLN", "length": 329, "header": "sp|Q862A9-1|GPBAR_BOVIN Isoform 1 of G protein-coupled bile acid receptor 1 OS=Bos taurus OX=9913 GN=GPBAR1 PE=2 SV=1 CANONICAL=Q862A9-1" }, "locus": { "chromosome": "2", "start_pos": 106293093, "end_pos": 106292107, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090396.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090396.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084345.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084345.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 154, "start_aa": "Asn", "end_pos": 154, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn154", "evidence": [ { "id": "Q862A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q862A9#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 4, "start_aa": "Asn", "end_pos": 4, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn4", "evidence": [ { "id": "Q862A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q862A9#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "A G protein-coupled receptor responsive to bile acids.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, Fukusumi S, Habata Y, Itoh T, Shintani Y, Hinuma S, Fujisawa Y, Fujino M", "evidence": [ { "database": "UniProtKB", "id": "Q862A9", "url": "https://www.uniprot.org/uniprotkb/Q862A9" } ], "reference": [ { "type": "PubMed", "id": "12524422", "url": "https://glygen.org/publication/PubMed/12524422" } ] }, { "title": "Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells.", "journal": "Arteriosclerosis, thrombosis, and vascular biology", "date": "2013-07", "authors": "Kida Taiki, Tsubosaka Yoshiki, Hori Masatoshi, Ozaki Hiroshi, Murata Takahisa", "evidence": [ { "database": "RefSeq", "id": "NP_778219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778219" } ], "reference": [ { "type": "PubMed", "id": "23619297", "url": "https://glygen.org/publication/PubMed/23619297" } ] }, { "title": "The bile acid receptor TGR5 inhibits platelet activation and thrombus formation.", "journal": "Platelets", "date": "2024-12", "authors": "Reusswig Friedrich, Reich Maria, Wienands Leonard, Herebian Diran, Keitel-Anselmino Verena, Elvers Margitta", "evidence": [ { "database": "RefSeq", "id": "NP_778219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778219" } ], "reference": [ { "type": "PubMed", "id": "38968449", "url": "https://glygen.org/publication/PubMed/38968449" } ] } ], "pathway": [ { "id": "bta:317756", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:317756", "resource": "KEGG Pathway" }, { "id": "R-BTA-373076", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373076", "resource": "Reactome", "description": "Class A/1 (Rhodopsin-like receptors)" }, { "id": "R-BTA-418555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "resource": "Reactome", "description": "G alpha (s) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AET1-1", "protein_name": "G-protein coupled bile acid receptor 1", "gene_name": "GPBAR1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTPNSTREVASPVPSGTLGLSLALASLIVAANLLLALGIAGDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLFLYLGPNFSFLSLLANLLLVHGERYMAVLRPLRPRGSTRLALILTWAGPLLFASLPALGWNHWVPGANCSSRTVFPAPYLYLEVYGLLLPAVGAAALLSARVLVTAHRQLQDIRRLERAVCRGAPSALARALTWRQARAQAGATLLFGLCWGPYVVTLLLSVLAYEQRPPLGPGTLLSLISLGSASAAAVPVAMGLGDHRYTAPWRAAARRWLRVLRVRSQGSPGPGTSYHTSCQSSVDLDLN", "length": 329 }, "evidence": [ { "id": "Q862A9", "url": "https://omabrowser.org/oma/group/Q862A9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M3AWA6-1", "protein_name": "G-protein coupled bile acid receptor 1 isoform X1", "gene_name": "gpbar1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKRMNLYNQSTIRKIVVLPREIKLARPIDCAVPMFSGLTLTADGDGLTIMDPEDKLSREKLIFYLTVPLSSIIIFTNLFIIIGIACNRQLHNTPNYFFLSLLVADLCTGITLPFIPRMSLDRQLDFRHCLVMYIFPNFLFLSFLFNLVMVHYERYLCIVSPLHHSQFWVHRCFPLALLTVWLPPLLYASLPAFGWNNWIEAASNKSLDSNETFWRSQTSHNASKEDEVCSYKQVFPKAFIYVEVCGLVLPAMLCIVCMTGRVLWIARKQLQDICKLHRAVDRLQTSDQEQQLNLRYAKCVAAVSLTFLVCWVPYIIYQLMSVTALQSGVSLPSSSLYIIMSCTGIGSMAVIPLILGLANKQYTEPIRRVMLKLRNRWRRGHSDRDITI", "length": 388 }, "evidence": [ { "id": "Q862A9", "url": "https://omabrowser.org/oma/group/Q862A9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q80SS6-1", "protein_name": "G protein-coupled bile acid receptor 1", "gene_name": "Gpbar1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMTPNSTELSAIPMGVLGLSLALASLIVIANLLLALGIALDRHLRSPPAGCFFLSLLLAGLLTGLALPMLPGLWSRNHQGYWSCLLLHLTPNFCFLSLLANLLLVHGERYMAVLQPLRPHGSVRLALFLTWVSSLFFASLPALGWNHWSPDANCSSQAVFPAPYLYLEVYGLLLPAVGATALLSVRVLATAHRQLCEIRRLERAVCRDVPSTLARALTWRQARAQAGATLLFLLCWGPYVATLLLSVLAYERRPPLGPGTLLSLISLGSTSAAAVPVAMGLGDQRYTAPWRTAAQRCLRVLRGRAKRDNPGPSTAYHTSSQCSIDLDLN", "length": 329 }, "evidence": [ { "id": "Q862A9", "url": "https://omabrowser.org/oma/group/Q862A9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q80T02-1", "protein_name": "G protein-coupled bile acid receptor 1", "gene_name": "Gpbar1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMSHNTTELSAIPRGVQELSLVLASLIVIANLLLALGIVLDRHLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNRSHQGYWSCLLLHLAPNFCFLSLLANLLLVHGERYMAVLQPLRPHGSVRLALFLTWISSLLFASLPALGWNHWSPGANCSSQAIFPAPYLYLEVYGLLLPAVGATALLSVRVLATAHHQLREIRRLERAVCRDAPSTLARALTWRQARAQAGATLLFLLCWGPYVATLLLSVLAYERRPPLGPVTLLSLISLGSASAAVVPVAMGLGDQRYTAPWRTAAQRWLQVLRGRPKRANPGPSTAYHSSSQCSTDLDLN", "length": 329 }, "evidence": [ { "id": "Q862A9", "url": "https://omabrowser.org/oma/group/Q862A9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8TDU6-1", "protein_name": "G protein-coupled bile acid receptor 1", "gene_name": "GPBAR1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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{ "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q8HXY9-1", "uniprot_ac": "Q8HXY9", "uniprot_id": "CFDP1_BOVIN", "mass": { "chemical_mass": 33355.0, "monoisotopic_mass": 33355.0 }, "refseq": { "ac": "NP_776693", "name": "heterochromatin-stabilizing protein CFDP1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776693" }, "gene_names": [ { "name": "CFDP1", "type": "recommended", "evidence": [ { "id": "Q8HXY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9" } ] }, { "name": "Bcnt/Cfdp1", "type": "synonym", "evidence": [ { "id": "NP_776693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776693" } ] }, { "name": "CFDP1", "type": "synonym", "evidence": [ { "id": "NP_776693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776693" } ] } ], "protein_names": [ { "name": "Heterochromatin-stabilizing protein CFDP1", "type": "recommended", "evidence": [ { "id": "Q8HXY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9/entry#names_and_taxonomy" } ] }, { "name": "Bucentaur", "type": "synonym", "evidence": [ { "id": "Q8HXY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9/entry#names_and_taxonomy" } ] }, { "name": "Craniofacial development protein 1", "type": "synonym", "evidence": [ { "id": "Q8HXY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9/entry#names_and_taxonomy" } ] }, { "name": "bucentaur", "type": "synonym", "evidence": [ { "id": "NP_776693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776693" } ] }, { "name": "chromatin stabilizing protein CFDP1", "type": "synonym", "evidence": [ { "id": "NP_776693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776693" } ] }, { "name": "craniofacial development protein 1", "type": "synonym", "evidence": [ { "id": "NP_776693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776693" } ] }, { "name": "h-type BCNT protein", "type": "synonym", "evidence": [ { "id": "NP_776693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776693" }, { "id": "Q8HXY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9/entry#names_and_taxonomy" } ] }, { "name": "heterochromatin-stabilizing protein CFDP1", "type": "synonym", "evidence": [ { "id": "NP_776693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776693" } ] }, { "name": "human-type Bcnt", "type": "synonym", "evidence": [ { "id": "NP_776693", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776693" } ] } ], "function": [ { "annotation": "Required for the structural stability of pericentromeric heterochromatin. Regulates heterochromatin state by stabilizing CBX5/HP1alpha and H3K9me3 at major satellites and CENPA at minor satellites and is required for incorporation of histone H2AZ1/H2AZ into chromatin. Maintenance of chromatin structure promotes binding of guanine-nucleotide releasing factor RCC1 to minor and major satellite repeats. Chromatin-bound RCC1 maintains high levels of GTP-bound RAN near the centromeric heterochromatin, facilitating RAN-mediated microtubule nucleation during mitosis. Plays a role in craniofacial development. Required to maintain normal cell function in embryonic development.", "evidence": [ { "database": "UniProtKB", "id": "Q8HXY9", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9#function" }, { "database": "UniProtKB", "id": "O88271", "url": "https://www.uniprot.org/uniprotkb/O88271#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q8HXY9", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CFDP1", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9", "locus": {} } ], "crossref": [ { "id": "Q8HXY9", "url": "https://alphafold.ebi.ac.uk/entry/Q8HXY9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015427", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015427", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "281682", "url": "https://www.ncbi.nlm.nih.gov/gene/281682", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027124", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027124", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281682", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281682", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LDWAAYV", "url": "https://omabrowser.org/oma/group/LDWAAYV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q8HXY9", "url": "https://www.orthodb.org/?gene=Q8HXY9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48407", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48407", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48407:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48407:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07572", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07572", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_776693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776693", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q8HXY9", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8HXY9-1", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8HXY9-2", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEFDSEDFSTSEEDEDYVPSGGEYSEDDINELVKEDEVDGEEETQKTKGTKRKAESVLARKRKQGGLSLEEDEEDANEESGGSSSEEEDAATEQQKGVESEDARKKKEDELWASFLNDVGPKSKVPPSTHVKTGEETEETSSSHLVKAERLEKPKETEKVKITKVFDFAGEEVRVIKEVDATSKEAKSFFKQNEKEKPQSNVPPAVPSLPAGSGLKRSSGMSSLLGKIGAKKQKMSTLEKSKLDWESFKEEEGIGEELAIHNRGKEGYIERKAFLDRVDHRQFEIERDLRLSKMKP", "length": 297, "header": "sp|Q8HXY9-1|CFDP1_BOVIN Isoform 1 of Heterochromatin-stabilizing protein CFDP1 OS=Bos taurus OX=9913 GN=CFDP1 PE=2 SV=1 CANONICAL=Q8HXY9-1" }, "isoforms": [ { "isoform_ac": "Q8HXY9-1", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9/entry#Q8HXY9-1", "sequence": { "sequence": "MEEFDSEDFSTSEEDEDYVPSGGEYSEDDINELVKEDEVDGEEETQKTKGTKRKAESVLARKRKQGGLSLEEDEEDANEESGGSSSEEEDAATEQQKGVESEDARKKKEDELWASFLNDVGPKSKVPPSTHVKTGEETEETSSSHLVKAERLEKPKETEKVKITKVFDFAGEEVRVIKEVDATSKEAKSFFKQNEKEKPQSNVPPAVPSLPAGSGLKRSSGMSSLLGKIGAKKQKMSTLEKSKLDWESFKEEEGIGEELAIHNRGKEGYIERKAFLDRVDHRQFEIERDLRLSKMKP", "length": 297, "header": "sp|Q8HXY9-1|CFDP1_BOVIN Isoform 1 of Heterochromatin-stabilizing protein CFDP1 OS=Bos taurus OX=9913 GN=CFDP1 PE=2 SV=1 CANONICAL=Q8HXY9-1" }, "locus": {} }, { "isoform_ac": "Q8HXY9-2", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9/entry#Q8HXY9-2", "sequence": { "sequence": "MEEFDSEDFSTSEEDEDYVPSGGEYSEDDINELVKEDEVDGEEETQKTKGTKRKAESVLARKRKQGGLSLEEDEEDANEESGGSSSEEEDAATEQQKGVESEDARKKKEDELWASFLNDVGPKSKVPPSTHVKTGEETEETSSSHLVKAERLEKPKETEKVKITKVFDFAGEEVRVIKEVDATSKEAKSFFKQNEKEKPQSNVPPAVPSLPAGSG", "length": 215, "header": "sp|Q8HXY9-2|CFDP1_BOVIN Isoform 2 of Heterochromatin-stabilizing protein CFDP1 OS=Bos taurus OX=9913 GN=CFDP1 PE=2 SV=1 CANONICAL=Q8HXY9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 101, "end_pos": 101, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8HXY9", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9" } ], "site_lbl": "Ser101" }, { "start_pos": 115, "end_pos": 115, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8HXY9", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9" } ], "site_lbl": "Ser115" }, { "start_pos": 214, "end_pos": 214, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8HXY9", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9" } ], "site_lbl": "Ser214" }, { "start_pos": 21, "end_pos": 21, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8HXY9", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9" } ], "site_lbl": "Ser21" }, { "start_pos": 248, "end_pos": 248, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8HXY9", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9" } ], "site_lbl": "Ser248" }, { "start_pos": 26, "end_pos": 26, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8HXY9", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9" } ], "site_lbl": "Ser26" }, { "start_pos": 57, "end_pos": 57, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8HXY9", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9" } ], "site_lbl": "Ser57" }, { "start_pos": 81, "end_pos": 81, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8HXY9", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9" } ], "site_lbl": "Ser81" }, { "start_pos": 84, "end_pos": 84, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8HXY9", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9" } ], "site_lbl": "Ser84" }, { "start_pos": 85, "end_pos": 85, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8HXY9", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9" } ], "site_lbl": "Ser85" } ], "glycation": [], "keywords": [], "publication": [ { "title": "A transposable element-mediated gene divergence that directly produces a novel type bovine Bcnt protein including the endonuclease domain of RTE-1.", "journal": "Mol. Biol. Evol.", "date": "2003", "authors": "Iwashita Shintaro, Osada Naoki, Itoh Tomohito, Sezaki Mariko, Oshima Kenshiro, Hashimoto Etsuko, Kitagawa-Arita Yuko, Takahashi Ichiro, Masui Tohru, Hashimoto Katsuyuki, Makalowski Wojciech", "evidence": [ { "database": "UniProtKB", "id": "Q8HXY9", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9" } ], "reference": [ { "type": "PubMed", "id": "12832649", "url": "https://glygen.org/publication/PubMed/12832649" } ] } ], "pathway": [ { "id": "bta:281682", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281682", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BBX9-1", "protein_name": "Craniofacial development protein 1", "gene_name": "CFDP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEEFDSEDFSTSEEDEDYVPSGGEYSEDDVSELVKEDEVDGDEQTQKTKGKKRKAQSIPARKRKQGGLSFEEEEEENANEESGGSSSEEEDSAAEQEKGIGSEDARKKKEDELWASFLNDVGPKSKVPPSTHVKKGEETEETSSSKLLVKAEDLEKPKETEKVKITKVFDFAGEEVRVTKEVDATSKEAKSFFKQNEKEKPQANVPSALPSLAAGSGLKRSGGMSSLLGKIGAKKQKMSTLEKSKLDWESFKEEEGIGEELAIHNRGKEGYIERKAFLDRVDHRQFEIERDLRLSKMKP", "length": 299 }, "evidence": [ { "id": "Q8HXY9", "url": "https://omabrowser.org/oma/group/Q8HXY9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2M7J3-1", "protein_name": "Craniofacial development protein 1", "gene_name": "Cfdp1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEEFDSEDFSTSDEDEDYVPSGGEYSEDDVNELVKEDEVDGEEQAEKTKGKRRKAQDIPARKRKQSSLLLEDEEEDGKEESGGSGSEEDEEEQEGGLGSENARKKKEDELWASFLNDVGPKSKAASSSQVKAVEENEETSSNKLLVKADELEKPKESEKVKITKVFDFAGEEVRVTKEVDAASKEAKSFLKQNEKEKPQAVVTSAAAALPAGSGIKRSSGMSSLLGKIGAKKQKMSTLEKSKLDWESFKEEEGIGEELAIHNRGKEGYIERKAFLDRVDHRQFEIERDLRLSKMKP", "length": 296 }, "evidence": [ { "id": "Q8HXY9", "url": "https://omabrowser.org/oma/group/Q8HXY9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A3KPL8-1", "protein_name": "Craniofacial development protein 1", "gene_name": "cfdp1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNYSDYDSDGYSSNEDEDYVPSDDNLSEDDINDCVKEDALEGEDHDRQTPENLTKKKKKSKADVHMRKRKKGGLKLVEDGEASTADQQKDEDEPKEDDFVTKSVGDIEERQKKKADDLWASFLSDIPRPKAEVPSASSQKFTSAAATDEPSKLSTASSQKEDKPKDSSKITITKVFDFAGEEVRVTKEVDARSREAKSFLKNEEKLLEDTKEPSVSSEPQPPHPLSSGSSAKRPAGMGSILNRIGAKKQKMSTLEKSKMDWDAFKSEEGITDELAIHNRGKEGYVERKNFLERVDQRQFELEKTVRLNNMKR", "length": 312 }, "evidence": [ { "id": "Q8HXY9", "url": "https://omabrowser.org/oma/group/Q8HXY9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O88271-1", "protein_name": "Heterochromatin-stabilizing protein CFDP1", "gene_name": "Cfdp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEFDSEDFSTSDEDEDYLPSGGEYSEDDVNELVKEDEVDGEEQAEKTKGKRRKAQGIPARKRKQSGLLLEEEEDGKEDSGGSSSEEDEEEQEGGLGSENARKKKEDELWASFLNDVGPKSKAAPGSQTKVAEETEEISSNKPLVKADELDKPRESEKVKITKVFDFAGEEVRVTKEVDAASKEAKSFLKQTEREKPQALVTSPATPLPAGSGIKRASGMSSLLGKIGAKKQKMSTLEKSKLDWESFKEEEGIGEELAIHNRGKEGYIERKAFLDRVDHRQFEIERDLRLSKMKP", "length": 295 }, "evidence": [ { "id": "Q8HXY9", "url": "https://omabrowser.org/oma/group/Q8HXY9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P38326-1", "protein_name": "SWR1-complex protein 5", "gene_name": "SWC5", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MPEVETKIIPNEKEDEDEDGYIEEEDEDFQPEKDKLGGGSDDSDASDGGDDYDDGVNRDKGRNKVDYSRIESESGGLIKTRRARQAEEEYAKTHKYESLTVESIPAKVNSIWEELQEASKNRLLSSSGKVGSVLDGSKEARSTTAAQQEDKILIERNYKFAGETVHEKKWVSRSSAEGQEYLNSLKFKQQAPAAPVQLEKAVRTKSNESRQHLRRPLKRPPLLEQIISGGLRPKLTTLEKSQLDWASYVDRAGLNDELVLHNKDGFLARQEFLQRVGSAEDERYKELRRQQLAQQLQQDSEAS", "length": 303 }, "evidence": [ { "id": "Q8HXY9", "url": "https://omabrowser.org/oma/group/Q8HXY9/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q75UQ2-1", "protein_name": "Heterochromatin-stabilizing protein CFDP1", "gene_name": "Cfdp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEEFDSEDFSTSDEDEDYVPSGGEYSEDDVNELVKEDEVDGEEQAEKTKGKRRKAQSIPARKRKQSGLLLDEEEDGEEDSGGSSREEDEEEQEGGLGSETSRKKKEDELWASFLNDVGTKSKAASSSQVKVAEETEETSSSKPLVKADELEKPKESEKVKITKVFDFAGEEVRVTKEVDATSKEAKSFLKQTEKEKPQALVTSAATPPPAGSGIKRTSGMSSLLGKIGAKKQKMSTLEKSKLDWESFKEEEGIGEELAIHNRGKEGYIERKAFLERVDHRQFEIERDLRLSKMKP", "length": 295 }, "evidence": [ { "id": "Q8HXY9", "url": "https://omabrowser.org/oma/group/Q8HXY9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9UEE9-1", "protein_name": "Heterochromatin-stabilizing protein CFDP1", "gene_name": "CFDP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEFDSEDFSTSEEDEDYVPSGGEYSEDDVNELVKEDEVDGEEQTQKTQGKKRKAQSIPARKRRQGGLSLEEEEEEDANSESEGSSSEEEDDAAEQEKGIGSEDARKKKEDELWASFLNDVGPKSKVPPSTQVKKGEETEETSSSKLLVKAEELEKPKETEKVKITKVFDFAGEEVRVTKEVDATSKEAKSFFKQNEKEKPQANVPSALPSLPAGSGLKRSSGMSSLLGKIGAKKQKMSTLEKSKLDWESFKEEEGIGEELAIHNRGKEGYIERKAFLDRVDHRQFEIERDLRLSKMKP", "length": 299 }, "evidence": [ { "id": "Q8HXY9", "url": "https://omabrowser.org/oma/group/Q8HXY9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "Q8HXY9", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "Q8HXY9", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9" } ], "pmid": "" }, { "name": "Swr1 complex", "id": "GO:0000812", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000812", "evidence": [ { "database": "UniProtKB", "id": "Q8HXY9", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q8HXY9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 297, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q8HXY9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q8HXY9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q8HXY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8HXY9" }, { "id": "PRU00610", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00610" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BCNT-C", "eco_id": "ECO_0000255", "start_pos": 216, "end_pos": 297, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 21, 26, 57, 81, 84, 85, 101, 115, 214, 248 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 10 }, { "field": "total_sites", "count": 10 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q8MI28-1", "uniprot_ac": "Q8MI28", "uniprot_id": "LBN_BOVIN", "mass": { "chemical_mass": 137812.0, "monoisotopic_mass": 137812.0 }, "refseq": { "ac": "NP_776352", "name": "limbin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776352" }, "gene_names": [ { "name": "EVC2", "type": "recommended", "evidence": [ { "id": "Q8MI28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MI28" } ] }, { "name": "EVC2", "type": "synonym", "evidence": [ { "id": "NP_776352", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776352" } ] }, { "name": "LBN", "type": "synonym", "evidence": [ { "id": "NP_776352", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776352" }, { "id": "Q8MI28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MI28" } ] } ], "protein_names": [ { "name": "Limbin", "type": "recommended", "evidence": [ { "id": "Q8MI28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MI28/entry#names_and_taxonomy" } ] }, { "name": "Ellis van Creveld syndrome 2 (limbin)", "type": "synonym", "evidence": [ { "id": "NP_776352", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776352" } ] }, { "name": "limbin", "type": "synonym", "evidence": [ { "id": "NP_776352", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776352" } ] } ], "function": [ { "annotation": "Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis.", "evidence": [ { "database": "UniProtKB", "id": "Q8MI28", "url": "https://www.uniprot.org/uniprotkb/Q8MI28#function" }, { "database": "UniProtKB", "id": "Q8K1G2", "url": "https://www.uniprot.org/uniprotkb/Q8K1G2#function" } ] }, { "annotation": "The presence of a 2 bp deletion in exon 19 (c.2993_2994ACdel) led to a premature stop codon in the coding sequence of bovine EVC2, and was concordant with the recessive pattern of inheritance in affected and carrier animals. Erratum:[PLoS One. 2014;9(7):e102928] Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_776352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776352" }, { "database": "PubMed", "id": "24733244", "url": "https://glygen.org/publication/PubMed/24733244" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q8MI28", "url": "https://www.uniprot.org/uniprotkb/Q8MI28" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EVC2", "url": "https://www.uniprot.org/uniprotkb/Q8MI28", "locus": { "chromosome": "6", "start_pos": 103662794, "end_pos": 103500498, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004277", "url": "https://www.ensembl.org/id/ENSBTAG00000004277" } ] } } ], "crossref": [ { "id": "Q8MI28", "url": "https://alphafold.ebi.ac.uk/entry/Q8MI28", "database": "AlphaFoldDB", "categories": [] }, { "id": "280834", "url": "https://www.ncbi.nlm.nih.gov/gene/280834", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR022076", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022076", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026501", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026501", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:280834", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:280834", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q8MI28", "url": "https://www.orthodb.org/?gene=Q8MI28", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16795", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16795", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16795:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16795:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12297", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12297", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_776352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776352", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q8MI28", "url": "https://www.uniprot.org/uniprotkb/Q8MI28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8MI28-1", "url": "https://www.uniprot.org/uniprotkb/Q8MI28-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKFSKEIEVFNPPLASSASSGPWVHSVFAFTHSWPRKTLFKRDSAVTHRLYGDISRDFQGTSENGVIFQKCAVVSVQSEWPSAHVRLFVNNTRTPTAANLSDLFLLDNITGLTIRESAGNQTSRGFQAFRKKFLQVGDSFSVSYTASLEARDVGSGDILLLPAQLSFQSSSPNRTQLKAPFTITAEEKITVLPNHGLHAAGFCVAFILSLVLTWAVLFFMVRYQCVKGSSLTRHQVQHHENKLEHSQFTSADGVNEDLALNDQMIDILSSEDPGSMLQALEELEIATLNRADSDLEACRTQISKDIIALLLKNLTSSGQLSPQVERRMGAVFKKQFLLLEKEIQEEYDRKMVALTAECDLETRKKTESQYQREMAAMEEAEEVLKRVSERSAVECSSLLRTLHGLEQEHLRRSLALQQEEDLAKAHRQLAIFQRNELHNIFFTQIKSAIFKGELKPEAAKMLLQDYSKIQESVEELMDFFQASKRYHLSKRFGHREYLVQNIQSSETRMQGLLSTASAQLTLLIQKHERAGYLDEDQMQVLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLIIKRRREMLQKHKEQRREQLSIAEASGAAEDAGQYLGQWRGLMAEHSAALEELQERLDQAALDELRALTLSLSEKATEELRRLQNSGMTQELLKRGVPWLFLQQILEEHSRDLAARAERLEGEERDRGQEGVQSVRQRLKDDALEASTEEQAELRHWEHLIFTKLCSSAFSLSEEELLGMRQEVHGCFAQMDRSLALPKIRARVLLQRFQTAWREAEFLKLDQAMTAPELQPQSKARKPRSKSRSKIDLLKKCTEDKIQLFKEQAPEDLVEKVRGELLRERVQQLEAQEGLFAESLVSLQFQKAARMARTLWAYTALLSIQDLLLEELNSSETLTKSACMQILESHSPELQELERKLEDQLAHQEAAQLQRALDSWQQWAGEGPALLQEPEETDSERHVSAVLQRALSKGQKLLEYHQQSLREEQEDSVVLEDLLENMETDTFVTLYGQELRLASYLSKLTMLPGGTLRRLLTVALPAASQAELLAVLDSVGQKHQDHSVENDGSRVQADLGRRGKHQGWWQALESKLRGELINRGLEKMLWAQKRKESILKKTCPPLRERVIFSGKRSWPHLSLESTDELTPVPIVGAEAVDLLNTGEKLFIFRNPKEPEISLHVPPRKKKKNFLNAKKAAWALGLN", "length": 1209, "header": "sp|Q8MI28-1|LBN_BOVIN Isoform 1 of Limbin OS=Bos taurus OX=9913 GN=EVC2 PE=2 SV=1 CANONICAL=Q8MI28-1" }, "isoforms": [ { "isoform_ac": "Q8MI28-1", "url": "https://www.uniprot.org/uniprotkb/Q8MI28/entry#Q8MI28-1", "sequence": { "sequence": "MKFSKEIEVFNPPLASSASSGPWVHSVFAFTHSWPRKTLFKRDSAVTHRLYGDISRDFQGTSENGVIFQKCAVVSVQSEWPSAHVRLFVNNTRTPTAANLSDLFLLDNITGLTIRESAGNQTSRGFQAFRKKFLQVGDSFSVSYTASLEARDVGSGDILLLPAQLSFQSSSPNRTQLKAPFTITAEEKITVLPNHGLHAAGFCVAFILSLVLTWAVLFFMVRYQCVKGSSLTRHQVQHHENKLEHSQFTSADGVNEDLALNDQMIDILSSEDPGSMLQALEELEIATLNRADSDLEACRTQISKDIIALLLKNLTSSGQLSPQVERRMGAVFKKQFLLLEKEIQEEYDRKMVALTAECDLETRKKTESQYQREMAAMEEAEEVLKRVSERSAVECSSLLRTLHGLEQEHLRRSLALQQEEDLAKAHRQLAIFQRNELHNIFFTQIKSAIFKGELKPEAAKMLLQDYSKIQESVEELMDFFQASKRYHLSKRFGHREYLVQNIQSSETRMQGLLSTASAQLTLLIQKHERAGYLDEDQMQVLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLIIKRRREMLQKHKEQRREQLSIAEASGAAEDAGQYLGQWRGLMAEHSAALEELQERLDQAALDELRALTLSLSEKATEELRRLQNSGMTQELLKRGVPWLFLQQILEEHSRDLAARAERLEGEERDRGQEGVQSVRQRLKDDALEASTEEQAELRHWEHLIFTKLCSSAFSLSEEELLGMRQEVHGCFAQMDRSLALPKIRARVLLQRFQTAWREAEFLKLDQAMTAPELQPQSKARKPRSKSRSKIDLLKKCTEDKIQLFKEQAPEDLVEKVRGELLRERVQQLEAQEGLFAESLVSLQFQKAARMARTLWAYTALLSIQDLLLEELNSSETLTKSACMQILESHSPELQELERKLEDQLAHQEAAQLQRALDSWQQWAGEGPALLQEPEETDSERHVSAVLQRALSKGQKLLEYHQQSLREEQEDSVVLEDLLENMETDTFVTLYGQELRLASYLSKLTMLPGGTLRRLLTVALPAASQAELLAVLDSVGQKHQDHSVENDGSRVQADLGRRGKHQGWWQALESKLRGELINRGLEKMLWAQKRKESILKKTCPPLRERVIFSGKRSWPHLSLESTDELTPVPIVGAEAVDLLNTGEKLFIFRNPKEPEISLHVPPRKKKKNFLNAKKAAWALGLN", "length": 1209, "header": "sp|Q8MI28-1|LBN_BOVIN Isoform 1 of Limbin OS=Bos taurus OX=9913 GN=EVC2 PE=2 SV=1 CANONICAL=Q8MI28-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 120, "start_aa": "Asn", "end_pos": 120, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn120", "evidence": [ { "id": "Q8MI28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MI28#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Positional cloning of the gene LIMBIN responsible for bovine chondrodysplastic dwarfism.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2002", "authors": "Takeda Haruko, Takami Marika, Oguni Tomoko, Tsuji Takehito, Yoneda Kazuhiro, Sato Hiroaki, Ihara Naoya, Itoh Tomohito, Kata Srinivas R, Mishina Yuji, Womack James E, Moritomo Yasuo, Sugimoto Yoshikazu, Kunieda Tetsuo", "evidence": [ { "database": "UniProtKB", "id": "Q8MI28", "url": "https://www.uniprot.org/uniprotkb/Q8MI28" } ], "reference": [ { "type": "PubMed", "id": "12136126", "url": "https://glygen.org/publication/PubMed/12136126" } ] }, { "title": "Deletion in the EVC2 gene causes chondrodysplastic dwarfism in Tyrolean Grey cattle.", "journal": "PloS one", "date": "2014", "authors": "Murgiano Leonardo, Jagannathan Vidhya, Benazzi Cinzia, Bolcato Marilena, Brunetti Barbara, Muscatello Luisa Vera, Dittmer Keren, Piffer Christian, Gentile Arcangelo, Dr\u00f6gem\u00fcller Cord", "evidence": [ { "database": "RefSeq", "id": "NP_776352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776352" } ], "reference": [ { "type": "PubMed", "id": "24733244", 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"sequence": "MAASSSLVPDRLRLPLCFLGVFVCYFYYGILQEKITRGKYGEGAKQETFTFALTLVFIQCVVNAVFAKILIQFFDTARVDRTRSWLYAACSVSYLGAMVSSNSALQFVNYPTQVLGKSCKPIPVMLLGVTLLKKKYPMAKYLCVLLIVAGVALFMYKPKKVVGIEEHTIGYGELLLLLSLTLDGLTGVSQDHMRAHYQTGSNHMMLNINLWSTLLLGAGILFTGELWEFLSFAERYPTIVYNILLFGLTSALGQSFIFMTVVYFGPLTCSIITTTRKFFTILASVILFANPISPMQWVGTVLVFLGLGLDAKFGKGAKKTSH", "length": 322, "header": "sp|Q8MII5-1|S35B1_BOVIN Isoform 1 of Solute carrier family 35 member B1 OS=Bos taurus OX=9913 GN=SLC35B1 PE=2 SV=2 CANONICAL=Q8MII5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The nucleotide-sugar transporter family: a phylogenetic approach.", "journal": "Biochimie", "date": "2003", "authors": "Martinez-Duncker Ivan, Mollicone Rosella, Codogno Patrice, Oriol Rafael", "evidence": [ { "database": "UniProtKB", "id": "Q8MII5", "url": "https://www.uniprot.org/uniprotkb/Q8MII5" } ], "reference": [ { "type": "PubMed", "id": "12770764", "url": 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"url": "https://www.ensembl.org/id/ENSBTAG00000011203" } ] } } ], "crossref": [ { "id": "Q8MJ05", "url": "https://alphafold.ebi.ac.uk/entry/Q8MJ05", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd17147", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17147", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "280916", "url": "https://www.ncbi.nlm.nih.gov/gene/280916", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003533", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003533", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036572", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036572", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:280916", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:280916", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q8MJ05", "url": "https://www.orthodb.org/?gene=Q8MJ05", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23005", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23005", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23005:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23005:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03607", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03607", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q8MJ05", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8MJ05-1", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"length": 2105, "header": "sp|Q8MJ05-1|RP1_BOVIN Isoform 1 of Oxygen-regulated protein 1 OS=Bos taurus OX=9913 GN=RP1 PE=2 SV=1 CANONICAL=Q8MJ05-1" }, "isoforms": [ { "isoform_ac": "Q8MJ05-1", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05/entry#Q8MJ05-1", "sequence": { "sequence": "MSETPSTSFSMVRRISSEGQLPSPRQLGITQPVVAKRISFYKSGDPQFGGVRVVLNPRSFKTFDALLDNLSGKVPLPFGVRNISTPRGRHSITRLEELEDGQSYLCSHGRKVQPVDLDKARRRPRPWLSSRALSTHVQRGPAPAAPGMLRAPRRLVVFRNGDPKTRRAIVLNRRVTQSFEVFLQYLTQVMQRPVTKLYATDGRKVPSLQAVILSSGAVVAAGREPFKPGNYDIQKYLLPARLPGISRRVYPKGNARSESRKMSTHVSSSPTSQIYSLSSEKMQNNDSYSDHSFASENYLALEKNDSQNLLIYPSEDDVEKSIIFNQDGTMTVEMKIRFKIKEEETIKWTTTLCRADLSNNGEKSEINSLPGRTDDRSSGVKITACSLSADVSPLEKGGSQVDSLAEEANTQVKDQDVETGSSTSWENPALDTDATQGTQDRVKHRFYRPPTPGPRRVRQKKSVIGSVTLVSETEVQEKMIGQFSYNEERKDWENKSEYHMVTHSCSKMSSVSNRPILVQVDNDEQVASSLERKKESRLLKSSAVSAGVVEITSQKTLEMSHNGGLPQTTSEKSIVEEGIVDNVIADNKARVRNLRTYGNTDDRSSPFLGDAAHFSSNNPGTDKTISKTPASVGNSTVTTRIDQLIHEFSHCGLTKLPENEKQISSSVASKKKMKSQQHVINSQHQAGEMATKRIPRKNKRMNTRGRIAQETILRDSHSSLKGAILCEKDLHASDTVIESNYFSSKGNNPVNSRNFPRNKLNTIHKPKIQGLLARRKSRPLNKVNLGGPTKREIGQGEKVFSHNEIGCCKNTFENQNLFHLFNFLEQKPNAFCGPESQAETASWYLRGTSKRSLVSKVNNSHITLRSQKKQKRDKLKSDTTVSKEHVTTRANSLASLEKAVFPENVTHHSVQSYVQRWLQNLSPQAALQLGKSAPVYKKERGVASYNNGFLPGNSSHTSSGKRNDSILQSNRHTTKSASLTGDNLGKRVGMSFDKNSSEELIQDHCESQTDSLNDTYLLSVHEFCTLSQSATDDPNAKSQVSAAKSGQEMSLVYKDINLAAKGPSVETAVQVDLEGDTPQHLSPVQLLHQLQALVPSSPKAQNGVVQMPGPLSEVPFPSLIRNSSTNVLLAWLLVLTLKGGVSSFCPGDALKATSGSSEALALLEVLKHIAVTEEADDLKAAVASLVESTTNHSGLTEKEQDVGPIGLSANCSTPNIQIIPQCAENEKTQKISLDGSHTAGEEVSEVCVTAVTRSPRKMGTVVKTYPPEETCHLSEDSFPSDDCTMDQTSMNKACFLGDISSLTEAVSSHEGCAYEQNHIYERADNLELTKELERVDEVQKDRNILADPGCKHGSNMLVSHQSASSLSPCGSFQNTTESELDGEHSFLDKSESCSLKKFQDKSVYTSFDKEDSKTSEEPGSTTNSMTSSERNVSEMESFEELENQNTDIFNIKVNSGEQVTEELIREELEAGKSLELIEVSSRNDAEEGKDGVICETISRKLVTPPSLVFCYDSKQNMEKEPSEGETETKVRKMVESLEAGSSAESPLNFKSGLRRSGTSDWSDYRQNSENEPSYKASSNGPSDSDEEMTPEKECNKGFVKRTIEKLYGKAEMMRPFFFRWIYTHISGLSCDSVEFQGTGKVGLYDPEGQSLGSLERVSSNSTVLQKFPEQKRDKCDVNNVRASYPREDIAEHGTKQNDHKTILRDREEGVLIDKGKWLLKENHLLRLSSPECSGPCGHADTTSVDTLLDNSSTEVPYSHFGNLAPGPNMAELSSSELEELTQPPELRCNYFNVPHCSDSEPFHDDELDTQDEACAQEREPNHPAEEKGNLRSERVCTSATHVFASAGNKVHPVSDGAVRNQPLAGSNVIHGALQEGDSLDKLYNICGQHCPILTVINQPVNEEHRGFAYCKDSDVENSLSLQLWMKIHPCLRHSSKTMFRDKNNKTISRRALTDNAVGNTHVWPHFNNTFDLMDRRRKLKQSNCLGLEEENNFNKFQSYLKNFLHTLLLVVGQVNSNPQDPSSQTKEFFEVVDENNNLLNSRFQNSGTNLNQVVREHSYHLSFEMLGQARLFCQVETFLGISNRNILEMFYIFEDENLFIWEEEN", "length": 2105, "header": "sp|Q8MJ05-1|RP1_BOVIN Isoform 1 of Oxygen-regulated protein 1 OS=Bos taurus OX=9913 GN=RP1 PE=2 SV=1 CANONICAL=Q8MJ05-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 451, "start_aa": "Thr", "end_pos": 451, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr451", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:280916", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:280916", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ05", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ05", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05" } ], "pmid": "" }, { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ05", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05" } ], "pmid": "" }, { "name": "photoreceptor cell maintenance", "id": "GO:0045494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045494", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ05", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05" } ], "pmid": "" }, { "name": "retina development in camera-type eye", "id": "GO:0060041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060041", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ05", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05" } ], "pmid": "" }, { "name": "photoreceptor cell outer segment organization", "id": "GO:0035845", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035845", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ05", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05" } ], "pmid": "" }, { "name": "retinal rod cell development", "id": "GO:0046548", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046548", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ05", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05" } ], "pmid": "" }, { "name": "response to light stimulus", "id": "GO:0009416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009416", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ05", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05" } ], "pmid": "" }, { "name": "photoreceptor cell development", "id": "GO:0042461", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042461", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ05", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05" } ], "pmid": "" }, { "name": "axoneme assembly", "id": "GO:0035082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035082", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ05", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05" } ], "pmid": "" }, { "name": "retinal cone cell development", "id": "GO:0046549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046549", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ05", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "photoreceptor inner segment", "id": "GO:0001917", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001917", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ05", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05" } ], "pmid": "" }, { "name": "microtubule associated complex", "id": "GO:0005875", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005875", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ05", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ05", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05" } ], "pmid": "" }, { "name": "photoreceptor connecting cilium", "id": "GO:0032391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032391", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ05", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05" } ], "pmid": "" }, { "name": "photoreceptor outer segment", "id": "GO:0001750", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001750", "evidence": [ { "database": "UniProtKB", "id": "Q8MJ05", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1013, "end_pos": 1015, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1122, "end_pos": 1124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1191, "end_pos": 1193, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1210, "end_pos": 1212, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1374, "end_pos": 1376, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1431, "end_pos": 1433, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1660, "end_pos": 1662, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1750, "end_pos": 1752, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1944, "end_pos": 1946, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1967, "end_pos": 1969, "annotation": "n_glycosylation_sequon" }, { "start_pos": 285, "end_pos": 287, "annotation": 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"biomarkers": [], "structures": [ { "pdb_id": "AF-Q8MJ05-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 2105, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q8MJ05-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q8MJ05" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q8MJ05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05" }, { "id": "PRU00072", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00072" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Doublecortin 1", "eco_id": "ECO_0000255", "start_pos": 36, "end_pos": 118, "start_aa": "Lys", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "Q8MJ05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MJ05" }, { "id": "PRU00072", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00072" } ], "ann_type": 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"MAYPWTFTFLCGLLAANLVGATLSPPVVLSLSTEVIKQMLAQKLKNHDVTNTLQQLPLLTAMEEESSRGIFGNLVKSILKHILWMKVTSASIGQLQVQPLANGRQLMVKAPLDVVAGFNVPLFKTVVELHVEVEAQAIIHVETREKDHARLVLSECSNTGGSLRVSLLHKLSFLLKCLADKVISLLTPAPPKLVKSELCPVLKAGFEDMRGELLNLTKVPMSLNSEHLKLDFISPVIDHSVVHLILGARLFNSEGKVTKLFNVAGDSLNLPTLNQTPFRLTVRKDVVVAIIAALIHSGKLTVLLDYVLPEVARQLRSSIKVIDETAAAQLGPTQIVKIMSQTTPMLILDQGNAKVAQLIVLEIFATDKDSRPLFTLGIEASSDIQFYVEDGLLVFSFNEIRADRIHLMNSDIGVFNPKLLNNITTKILTSILLPNENGKLRSGIPVSMVKNLGFKSISLSLTKEALVVTQASS", "length": 473, "header": "sp|Q8SPF8-1|BPIB1_BOVIN Isoform 1 of BPI fold-containing family B member 1 OS=Bos taurus OX=9913 GN=BPIFB1 PE=2 SV=1 CANONICAL=Q8SPF8-1" }, "isoforms": [ { "isoform_ac": "Q8SPF8-1", "url": "https://www.uniprot.org/uniprotkb/Q8SPF8/entry#Q8SPF8-1", "sequence": { "sequence": 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Biophys. 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"bta:282643", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282643", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q8SPF8", "url": "https://www.uniprot.org/uniprotkb/Q8SPF8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "Q8SPF8", "url": "https://www.uniprot.org/uniprotkb/Q8SPF8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "innate immune response in mucosa", "id": "GO:0002227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002227", "evidence": [ { "database": "UniProtKB", "id": "Q8SPF8", 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"prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 7, "start_aa": "Asn", "end_pos": 7, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn7", "evidence": [ { "id": "Q8SPN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPN1#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2002", "authors": "Masuda Yasushi, Takatsu Yoshihiro, Terao Yasuko, Kumano Satoshi, Ishibashi Yoshihiro, Suenaga Masato, Abe Michiko, Fukusumi Shoji, Watanabe Takuya, Shintani Yasushi, Yamada Takao, Hinuma Shuji, Inatomi Nobuhiro, Ohtaki Tetsuya, Onda Haruo, Fujino Masahiko", "evidence": [ { "database": "UniProtKB", "id": "Q8SPN1", "url": "https://www.uniprot.org/uniprotkb/Q8SPN1" } ], "reference": [ { "type": "PubMed", "id": "12054613", "url": "https://glygen.org/publication/PubMed/12054613" } ] } ], "pathway": [ { "id": "bta:282431", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282431", "resource": "KEGG Pathway" }, { "id": "R-BTA-375276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375276", "resource": "Reactome", "description": "Peptide ligand-binding receptors" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZK57-1", "protein_name": "Prokineticin receptor 2", "gene_name": "PROKR2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAQNGNASFASNFNPPQDHASSLSFNFSYGDYELPLDEDEDMTTTQTFFAAKIVIGVALVGIMLICGIGNFVFIVALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASLLIALVWMVSILIAIPSAYFATETVLFIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFLGPVVAMTLCYARISRELWFKAVPGFQTEQIRKRLRRRRKTVLVLMGILLAYVLCWAPFYGFAIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTVNCFKKMLLLHWRPSHRGSKSSMDHDLKTSSLPATEEVDCIRLK", "length": 384 }, "evidence": [ { "id": "Q8SPN1", "url": "https://omabrowser.org/oma/group/Q8SPN1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8K458-1", "protein_name": "Prokineticin receptor 2", "gene_name": "Prokr2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPN2#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2002", "authors": "Masuda Yasushi, Takatsu Yoshihiro, Terao Yasuko, Kumano Satoshi, Ishibashi Yoshihiro, Suenaga Masato, Abe Michiko, Fukusumi Shoji, Watanabe Takuya, Shintani Yasushi, Yamada Takao, Hinuma Shuji, Inatomi Nobuhiro, Ohtaki Tetsuya, Onda Haruo, Fujino Masahiko", "evidence": [ { "database": "UniProtKB", "id": "Q8SPN2", "url": "https://www.uniprot.org/uniprotkb/Q8SPN2" } ], "reference": [ { "type": "PubMed", "id": "12054613", "url": "https://glygen.org/publication/PubMed/12054613" } ] }, { "title": "Expression pattern of prokineticin 1 and its receptors in bovine ovaries during the estrous cycle: involvement in corpus luteum regression and follicular atresia.", "journal": "Biology of reproduction", "date": "2007-05", "authors": "Kisliouk Tatiana, Friedman Aharon, Klipper Eyal, Zhou Qun-Yong, Schams Dieter, Alfaidy Nadia, Meidan Rina", "evidence": [ { "database": "RefSeq", "id": "NP_776755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776755" } ], "reference": [ { "type": "PubMed", "id": "17229935", "url": "https://glygen.org/publication/PubMed/17229935" } ] } ], "pathway": [ { "id": "bta:281800", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281800", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "Q8SPN2", "url": "https://www.uniprot.org/uniprotkb/Q8SPN2" } ], "pmid": "" }, { "name": "neuropeptide Y receptor activity", "id": "GO:0004983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004983", "evidence": [ { "database": "UniProtKB", "id": "Q8SPN2", "url": "https://www.uniprot.org/uniprotkb/Q8SPN2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": 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"table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "Q8SPU6-1", "uniprot_ac": "Q8SPU6", "uniprot_id": "ACHB4_BOVIN", "mass": { "chemical_mass": 55946.0, "monoisotopic_mass": 55946.0 }, "refseq": { "ac": "NP_776942", "name": "neuronal acetylcholine receptor subunit beta-4 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776942" }, "gene_names": [ { "name": "CHRNB4", "type": "recommended", "evidence": [ { "id": "Q8SPU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPU6" } ] }, { "name": "ACRB4", "type": "synonym", "evidence": [ { "id": "Q8SPU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPU6" } ] }, { "name": "CHRNB4", "type": "synonym", "evidence": [ { "id": "NP_776942", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776942" } ] } ], "protein_names": [ { "name": "Neuronal acetylcholine receptor subunit beta-4", "type": "recommended", "evidence": [ { "id": "Q8SPU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPU6/entry#names_and_taxonomy" } ] }, { "name": "cholinergic receptor, nicotinic, beta 4 (neuronal)", "type": "synonym", "evidence": [ { "id": "NP_776942", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776942" } ] }, { "name": "cholinergic receptor, nicotinic, beta polypeptide 4", "type": "synonym", "evidence": [ { "id": "NP_776942", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776942" } ] }, { "name": "neuronal acetylcholine receptor subunit beta-4 precursor", "type": "synonym", "evidence": [ { "id": "NP_776942", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776942" } ] }, { "name": "neuronal acetylcholine receptor subunit beta-4", "type": "synonym", "evidence": [ { "id": "NP_776942", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776942" } ] }, { "name": "neuronal nicotinic receptor beta 4 subunit", "type": "synonym", "evidence": [ { "id": "NP_776942", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776942" } ] } ], "function": [ { "annotation": "Bovine chromaffin cells express nicotinic alpha3beta4 acetylcholine receptors", "evidence": [ { "database": "RefSeq", "id": "NP_776942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776942" }, { "database": "PubMed", "id": "12438106", "url": "https://glygen.org/publication/PubMed/12438106" } ] }, { "annotation": "Bovine chromaffin cells have an alpha3alpha7beta4 nicotinic receptor", "evidence": [ { "database": "RefSeq", "id": "NP_776942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776942" }, { "database": "PubMed", "id": "12438113", "url": "https://glygen.org/publication/PubMed/12438113" } ] }, { "annotation": "Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNB4 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3 and CHRNA4, as well as CHRNA5 and CHRNB3 as accesory subunits. CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor (By similarity). CHRNA3:CHRNB4 or CHRNA3:CHRNA5:CHRNB4 play also an important role in the habenulo-interpeduncular tract, modulating the mesolimbic dopamine system and affecting reward circuits and addiction (By similarity). Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q8SPU6", "url": "https://www.uniprot.org/uniprotkb/Q8SPU6#function" }, { "database": "UniProtKB", "id": "P30926", "url": "https://www.uniprot.org/uniprotkb/P30926#function" }, { "database": "UniProtKB", "id": "P12392", "url": "https://www.uniprot.org/uniprotkb/P12392#function" }, { "database": "UniProtKB", "id": "Q8R493", "url": "https://www.uniprot.org/uniprotkb/Q8R493#function" } ] }, { "annotation": "Data show that a basic residue at position 210 of the beta4 subunit slightly decreases alpha3beta4 receptor expression.", "evidence": [ { "database": "RefSeq", "id": "NP_776942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776942" }, { "database": "PubMed", "id": "21420959", "url": "https://glygen.org/publication/PubMed/21420959" } ] } ], "disease": [], "snv": [], "mutagenesis": [], 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"https://www.ebi.ac.uk/chembl/target/inspect/CHEMBL3350221", "database": "ChEMBL", "categories": [ "Chemical" ] }, { "id": "282181", "url": "https://www.ncbi.nlm.nih.gov/gene/282181", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282181", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282181", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q8SPU6", "url": "https://www.orthodb.org/?gene=Q8SPU6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18945", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02931", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02931", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02932", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02932", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_776942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776942", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29463", "url": "https://www.rhea-db.org/rhea/29463", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "29671", "url": "https://www.rhea-db.org/rhea/29671", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "34963", "url": "https://www.rhea-db.org/rhea/34963", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q8SPU6", "url": "https://www.uniprot.org/uniprotkb/Q8SPU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8SPU6-1", "url": "https://www.uniprot.org/uniprotkb/Q8SPU6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSALPLVLFSLVALCGRGDCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIQLQLSLAQLISVNEREQIMTTNIWLKQEWTDYRLAWNSSRYEGVNILRIPANRVWLPDIVLYNNADGSYEVSLYTNVVVRSNGSVMWLPPAICKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKMPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLNVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFIKRPRQQPSRAPQSSLARLTKSEATTTTTLAMGPTSSSNLYGNSMYFVNPGLAAPKSPVASDSAGIPRDFRLRSSGRFRQDVQEALEGVSFIAQHMKSDDLDQSVIEDWKYVAMVVDRLFLWVFVVVCVLGTVGLFLPPLFQTHTPSEEP", "length": 496, "header": "sp|Q8SPU6-1|ACHB4_BOVIN Isoform 1 of Neuronal acetylcholine receptor subunit beta-4 OS=Bos taurus OX=9913 GN=CHRNB4 PE=2 SV=1 CANONICAL=Q8SPU6-1" }, "isoforms": [ { "isoform_ac": "Q8SPU6-1", "url": "https://www.uniprot.org/uniprotkb/Q8SPU6/entry#Q8SPU6-1", "sequence": { "sequence": "MRSALPLVLFSLVALCGRGDCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIQLQLSLAQLISVNEREQIMTTNIWLKQEWTDYRLAWNSSRYEGVNILRIPANRVWLPDIVLYNNADGSYEVSLYTNVVVRSNGSVMWLPPAICKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKMPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLNVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFIKRPRQQPSRAPQSSLARLTKSEATTTTTLAMGPTSSSNLYGNSMYFVNPGLAAPKSPVASDSAGIPRDFRLRSSGRFRQDVQEALEGVSFIAQHMKSDDLDQSVIEDWKYVAMVVDRLFLWVFVVVCVLGTVGLFLPPLFQTHTPSEEP", "length": 496, "header": "sp|Q8SPU6-1|ACHB4_BOVIN Isoform 1 of Neuronal acetylcholine receptor subunit beta-4 OS=Bos taurus OX=9913 GN=CHRNB4 PE=2 SV=1 CANONICAL=Q8SPU6-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 138, "start_aa": "Asn", "end_pos": 138, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn138", "evidence": [ { "id": "Q8SPU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPU6#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 166, "start_aa": "Asn", "end_pos": 166, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn166", "evidence": [ { "id": "Q8SPU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPU6#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 36, "start_aa": "Asn", "end_pos": 36, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn36", "evidence": [ { "id": "Q8SPU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPU6#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 381, "start_aa": "Thr", "end_pos": 381, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr381", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 93, "start_aa": "Asn", "end_pos": 93, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn93", "evidence": [ { "id": "Q8SPU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SPU6#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Evidence for constitutive expression of bovine adrenal a3beta4* nicotinic acetylcholine receptors.", "journal": "Annals of the New York Academy of Sciences", "date": "2002-10", "authors": "Free R Benjamin, McKay Susan B, Boyd R Thomas, McKay Dennis B", "evidence": [ { "database": "RefSeq", "id": "NP_776942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776942" } ], "reference": [ { "type": "PubMed", "id": "12438106", "url": "https://glygen.org/publication/PubMed/12438106" } ] }, { "title": "A single neuronal nicotinic receptor alpha3alpha7beta4* is present in the bovine chromaffin cell.", "journal": "Annals of the New York Academy of Sciences", "date": "2002-10", "authors": "Maneu Victoria, Rojo Jonathan, Mulet Jose, Valor Luis Miguel, Sala Francisco, Criado Manuel, Garcia Antonio G, Gandia Luis", "evidence": [ { "database": "RefSeq", "id": "NP_776942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776942" } ], "reference": [ { "type": "PubMed", "id": "12438113", "url": "https://glygen.org/publication/PubMed/12438113" } ] }, { "title": "An extracellular RRR motif flanking the M1 transmembrane domain governs the biogenesis of homomeric neuronal nicotinic acetylcholine receptors.", "journal": "FEBS letters", "date": "2011-04-20", "authors": "Alves Daiane S, Castello-Banyuls Juan, Faura Clara C, Ballesta Juan J", "evidence": [ { "database": "RefSeq", "id": "NP_776942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776942" } ], "reference": [ { "type": "PubMed", "id": "21420959", "url": "https://glygen.org/publication/PubMed/21420959" } ] }, { "title": "Neuronal nicotinic acetylcholine receptors on bovine chromaffin cells: cloning, expression, and genomic organization of receptor subunits.", "journal": "J. Neurochem.", "date": "1997", "authors": "Campos-Caro A, Smillie F I, Dom\u00ednguez del Toro E, Rovira J C, Vicente-Agull\u00f3 F, Chapuli J, Ju\u00edz J M, Sala S, Sala F, Ballesta J J, Criado M", "evidence": [ { "database": "UniProtKB", "id": "Q8SPU6", "url": "https://www.uniprot.org/uniprotkb/Q8SPU6" } ], "reference": [ { "type": "PubMed", "id": "9003033", "url": "https://glygen.org/publication/PubMed/9003033" } ] } ], "pathway": [ { "id": "bta:282181", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282181", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q8SPU6", "url": "https://www.uniprot.org/uniprotkb/Q8SPU6" } ], "pmid": "" }, { "name": "acetylcholine-gated channel complex", "id": "GO:0005892", "url": 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] }, { "name": "MIP3A", "type": "synonym", "evidence": [ { "id": "Q8SQB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SQB1" } ] }, { "name": "SCYA20", "type": "synonym", "evidence": [ { "id": "Q8SQB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SQB1" } ] } ], "protein_names": [ { "name": "C-C motif chemokine 20", "type": "recommended", "evidence": [ { "id": "Q8SQB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8SQB1/entry#names_and_taxonomy" } ] }, { "name": "C-C motif chemokine 20 precursor", "type": "synonym", "evidence": [ { "id": "NP_776688", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776688" } ] }, { "name": "C-C motif chemokine 20", "type": "synonym", "evidence": [ { "id": "NP_776688", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776688" } ] }, { "name": "MIP-3-alpha", "type": "synonym", "evidence": [ { "id": "NP_776688", "database": "RefSeq", "url": 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Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells.", "evidence": [ { "database": "UniProtKB", "id": "Q8SQB1", "url": "https://www.uniprot.org/uniprotkb/Q8SQB1#function" }, { "database": "UniProtKB", "id": "P78556", "url": "https://www.uniprot.org/uniprotkb/P78556#function" }, { "database": "UniProtKB", "id": "O89093", "url": "https://www.uniprot.org/uniprotkb/O89093#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q8SQB1", "url": "https://www.uniprot.org/uniprotkb/Q8SQB1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCL20", "url": "https://www.uniprot.org/uniprotkb/Q8SQB1", "locus": { "chromosome": "2", "start_pos": 115951540, "end_pos": 115948297, 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Isoform 1 of C-C motif chemokine 20 OS=Bos taurus OX=9913 GN=CCL20 PE=3 SV=1 CANONICAL=Q8SQB1-1" }, "isoforms": [ { "isoform_ac": "Q8SQB1-1", "url": "https://www.uniprot.org/uniprotkb/Q8SQB1/entry#Q8SQB1-1", "sequence": { "sequence": "MMCSSKNLLLAALMSVLLLHFCSKSEASNFDCCLRYTERILHPSILVGFTQQLANEACDINAVVFYTRKKLAVCADPKKKWVKQVVHMLSQRVKRM", "length": 96, "header": "sp|Q8SQB1-1|CCL20_BOVIN Isoform 1 of C-C motif chemokine 20 OS=Bos taurus OX=9913 GN=CCL20 PE=3 SV=1 CANONICAL=Q8SQB1-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:281666", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281666", "resource": "KEGG Pathway" }, { "id": "R-BTA-380108", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380108", "resource": "Reactome", "description": "Chemokine receptors bind chemokines" }, { "id": "R-BTA-418594", "name": "", "url": 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"OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P78556-1", "protein_name": "C-C motif chemokine 20", "gene_name": "CCL20", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MCCTKSLLLAALMSVLLLHLCGESEAASNFDCCLGYTDRILHPKFIVGFTRQLANEGCDINAIIFHTKKKLSVCANPKQTWVKYIVRLLSKKVKNM", "length": 96 }, "evidence": [ { "id": "Q8SQB1", "url": "https://omabrowser.org/oma/group/Q8SQB1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P97884-1", "protein_name": "C-C motif chemokine 20", "gene_name": "Ccl20", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MACKHLPFLALAGVLLAYLCSQSEAASNFDCCLTYTKNVYHHARNFVGFTTQMADEACDINAIIFHLKSKRSVCADPKQIWVKRILHLLSLRTKKM", "length": 96 }, "evidence": [ { "id": "Q8SQB1", "url": "https://omabrowser.org/oma/group/Q8SQB1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8QG55-1", "protein_name": "C-C motif chemokine", "gene_name": "CCL20", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPGLSTKSLILASLLGLLLLLLCSTSQAQSNQDCCLSYSKVRLPRKVIKGFTEQLSGEVCDIDAIIFHTVRGLKACVNPKEDWVKKHLLFLSQKLKRMSM", "length": 100 }, "evidence": [ { "id": "Q8SQB1", "url": "https://omabrowser.org/oma/group/Q8SQB1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q8SQB1", "url": "https://www.uniprot.org/uniprotkb/Q8SQB1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "chemotaxis", "id": "GO:0006935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006935", "evidence": [ { "database": "UniProtKB", "id": "Q8SQB1", "url": "https://www.uniprot.org/uniprotkb/Q8SQB1" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "Q8SQB1", "url": "https://www.uniprot.org/uniprotkb/Q8SQB1" } ], "pmid": "" }, { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "Q8SQB1", "url": "https://www.uniprot.org/uniprotkb/Q8SQB1" } ], "pmid": "" }, { "name": "calcium-mediated signaling", "id": "GO:0019722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019722", "evidence": [ { "database": "UniProtKB", "id": "Q8SQB1", "url": "https://www.uniprot.org/uniprotkb/Q8SQB1" } ], "pmid": "" }, { "name": "cell chemotaxis", "id": "GO:0060326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060326", "evidence": [ { "database": "UniProtKB", "id": "Q8SQB1", "url": "https://www.uniprot.org/uniprotkb/Q8SQB1" } ], "pmid": "" }, { "name": "T cell migration", "id": "GO:0072678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072678", "evidence": [ { "database": "UniProtKB", "id": "Q8SQB1", "url": "https://www.uniprot.org/uniprotkb/Q8SQB1" } ], "pmid": "" }, { "name": "thymocyte migration", "id": "GO:0072679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072679", "evidence": [ { "database": "UniProtKB", "id": "Q8SQB1", "url": "https://www.uniprot.org/uniprotkb/Q8SQB1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "chemokine activity", "id": "GO:0008009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008009", "evidence": [ { "database": "UniProtKB", "id": "Q8SQB1", "url": "https://www.uniprot.org/uniprotkb/Q8SQB1" } ], "pmid": "" }, { "name": "CCR6 chemokine receptor binding", "id": "GO:0031731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031731", "evidence": [ { "database": "UniProtKB", "id": "Q8SQB1", "url": "https://www.uniprot.org/uniprotkb/Q8SQB1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q8SQB1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 96, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q8SQB1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q8SQB1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { 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"o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "Q8WMX8-1", "uniprot_ac": "Q8WMX8", "uniprot_id": "ASZ1_BOVIN", "mass": { "chemical_mass": 53184.0, "monoisotopic_mass": 53184.0 }, "refseq": { "ac": "NP_776488", "name": "ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776488" }, "gene_names": [ { "name": "ASZ1", "type": "recommended", "evidence": [ { "id": "Q8WMX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8WMX8" } ] }, { "name": "ASZ1", "type": "synonym", "evidence": [ { "id": "NP_776488", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776488" } ] }, { "name": "GASZ", "type": "synonym", "evidence": [ { "id": "NP_776488", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776488" }, { "id": "Q8WMX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8WMX8" } ] } ], "protein_names": [ { "name": "Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "Q8WMX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8WMX8/entry#names_and_taxonomy" } ] }, { "name": "Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein", "type": "synonym", "evidence": [ { "id": "Q8WMX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8WMX8/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_776488", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776488" } ] }, { "name": "germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein", "type": "synonym", "evidence": [ { "id": "NP_776488", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776488" } ] } ], "function": [ { "annotation": "Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q8WMX8", "url": "https://www.uniprot.org/uniprotkb/Q8WMX8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q8WMX8", "url": "https://www.uniprot.org/uniprotkb/Q8WMX8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASZ1", "url": "https://www.uniprot.org/uniprotkb/Q8WMX8", "locus": { "chromosome": "4", "start_pos": 51080354, "end_pos": 51002327, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000169", "url": "https://www.ensembl.org/id/ENSBTAG00000000169" } ] } } ], "crossref": [ { "id": "Q8WMX8", "url": "https://alphafold.ebi.ac.uk/entry/Q8WMX8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000169", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000169", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09521", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09521", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "281184", "url": "https://www.ncbi.nlm.nih.gov/gene/281184", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281184", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281184", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FVCKLTF", "url": "https://omabrowser.org/oma/group/FVCKLTF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q8WMX8", "url": "https://www.orthodb.org/?gene=Q8WMX8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24157", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24157", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24157:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24157:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07647", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07647", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13637", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13637", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_776488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776488", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q8WMX8", "url": "https://www.uniprot.org/uniprotkb/Q8WMX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8WMX8-1", "url": "https://www.uniprot.org/uniprotkb/Q8WMX8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAGPLRGLAVAGGGESSDSEDDGWEIGYLDRKSQKLKGPLPVEERQETFKKALTTGNISLVEELLDSGISVDTSFQYGWTSLMYAASVSNVELVRVLLDRGANASFDKDKQTVLITACSARGSEEKILKCIELLLSRNADPNVACRRLMTPIMYAARDGHPQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLELGANKMIQTKDGKTPSEIAKRNKHLEIFNFLSLTLNPLEGKLHQLTKEESICKLLRTDSDKEKDHIFSSYTAFGDLEIFLHGLGLEHMTDLLKEREITLRHLLTMRKDELAKNGITSRDQQKIMAALKELEVEEIKFGELPEVAKLEISGDEFLNFLLKLNKQCGHLITAVQNIITELPVNSHKIVLEWASPRNFTSVCEELVSNVEDLSEEVCKLKDLIQKLQNERENDPTHIPLMEEVSTWNSRILKRTAITVCGFGFLLFICKLAFQRK", "length": 475, "header": "sp|Q8WMX8-1|ASZ1_BOVIN Isoform 1 of Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 OS=Bos taurus OX=9913 GN=ASZ1 PE=2 SV=1 CANONICAL=Q8WMX8-1" }, "isoforms": [ { "isoform_ac": "Q8WMX8-1", "url": "https://www.uniprot.org/uniprotkb/Q8WMX8/entry#Q8WMX8-1", "sequence": { "sequence": "MAAGPLRGLAVAGGGESSDSEDDGWEIGYLDRKSQKLKGPLPVEERQETFKKALTTGNISLVEELLDSGISVDTSFQYGWTSLMYAASVSNVELVRVLLDRGANASFDKDKQTVLITACSARGSEEKILKCIELLLSRNADPNVACRRLMTPIMYAARDGHPQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNVVLKLLELGANKMIQTKDGKTPSEIAKRNKHLEIFNFLSLTLNPLEGKLHQLTKEESICKLLRTDSDKEKDHIFSSYTAFGDLEIFLHGLGLEHMTDLLKEREITLRHLLTMRKDELAKNGITSRDQQKIMAALKELEVEEIKFGELPEVAKLEISGDEFLNFLLKLNKQCGHLITAVQNIITELPVNSHKIVLEWASPRNFTSVCEELVSNVEDLSEEVCKLKDLIQKLQNERENDPTHIPLMEEVSTWNSRILKRTAITVCGFGFLLFICKLAFQRK", "length": 475, "header": "sp|Q8WMX8-1|ASZ1_BOVIN Isoform 1 of Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 OS=Bos taurus OX=9913 GN=ASZ1 PE=2 SV=1 CANONICAL=Q8WMX8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 17, "end_pos": 17, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8WMX8", "url": "https://www.uniprot.org/uniprotkb/Q8WMX8" } ], "site_lbl": "Ser17" }, { "start_pos": 18, "end_pos": 18, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8WMX8", "url": "https://www.uniprot.org/uniprotkb/Q8WMX8" } ], "site_lbl": "Ser18" }, { "start_pos": 20, "end_pos": 20, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8WMX8", "url": "https://www.uniprot.org/uniprotkb/Q8WMX8" } ], "site_lbl": "Ser20" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Identification of Gasz, an evolutionarily conserved gene expressed exclusively in germ cells and encoding a protein with four ankyrin repeats, a sterile-alpha motif, and a basic leucine zipper.", "journal": "Mol. Endocrinol.", "date": "2002", "authors": "Yan Wei, Rajkovic Aleksandar, Viveiros Maria M, Burns Kathleen H, Eppig John J, Matzuk Martin M", "evidence": [ { "database": "UniProtKB", "id": "Q8WMX8", "url": "https://www.uniprot.org/uniprotkb/Q8WMX8" } ], "reference": [ { "type": "PubMed", "id": "12040005", "url": "https://glygen.org/publication/PubMed/12040005" } ] }, { "title": "Comparative analyses of multi-species sequences from targeted genomic regions.", "journal": "Nature", "date": "2003", "authors": "Thomas JW, Touchman JW, Blakesley RW, Bouffard GG, Beckstrom-Sternberg SM, Margulies EH, Blanchette M, Siepel AC, Thomas PJ, McDowell JC, Maskeri B, Hansen NF, Schwartz MS, Weber RJ, Kent WJ, Karolchik D, Bruen TC, Bevan R, Cutler DJ, Schwartz S, Elnitski L, Idol JR, Prasad AB, Lee-Lin SQ, Maduro VV, Summers TJ, Portnoy ME, Dietrich NL, Akhter N, Ayele K, Benjamin B, Cariaga K, Brinkley CP, Brooks SY, Granite S, Guan X, Gupta J, Haghighi P, Ho SL, Huang MC, Karlins E, Laric PL, Legaspi R, Lim MJ, Maduro QL, Masiello CA, Mastrian SD, McCloskey JC, Pearson R, Stantripop S, Tiongson EE, Tran JT, Tsurgeon C, Vogt JL, Walker MA, Wetherby KD, Wiggins LS, Young AC, Zhang LH, Osoegawa K, Zhu B, Zhao B, Shu CL, De Jong PJ, Lawrence CE, Smit AF, Chakravarti A, Haussler D, Green P, Miller W, Green ED", "evidence": [ { "database": "UniProtKB", "id": "Q8WMX8", "url": "https://www.uniprot.org/uniprotkb/Q8WMX8" } ], "reference": [ { "type": "PubMed", "id": "12917688", "url": "https://glygen.org/publication/PubMed/12917688" } ] } ], "pathway": [ { "id": "bta:281184", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281184", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8VHF9-1", "protein_name": "Protein Wnt", "gene_name": "Asz1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAGTLRGLAVAGGGESSDSEDDGWDIGYLDRSSQKLKRSLPVEEKNETFKKALTTGDISLVKELLDSGINVDSSFRYGWTPLMYAASVANVELVRFLLDRGANASFDKDKLTVLITACSARGSEEQVLKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNAQDENGYTALTWAARQGHKNVILKLLELGANKMLQTKDGRTPSEIAKRNKHLEIFNFLSLTLNPLEGKLQQLTKEETICKLLATDSDKEKDHIFSPYTAFGDLEIFLHGLGLEHMTDLLKERDITLRHLLTMKKDELTKNGITSKDQQKILAALKELEVEEINFGKLPEVAKLEISGDEFLNFLLKLNKQCGHLITAVQNIITELPVNSHKIVLEWASPRNFTSVCEELVSNVEDLNEEVCRLKELIQKMQNERENDPTHIPLVEEVSPWKTRILKRYMRATGGSSRVMCDNVPGLVSRQRQLCHRHPDVMRAIGLGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRVLLRSSRESAFVYAISSAGVVFAITRACSQGELKSCSCDPKKKGSGKDSKGTFDWGGCSDNIDYGIKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANKRFKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCECKFHWCCAVRCQDCLEALDVHTCKAPKSADWTTPT", "length": 785 }, "evidence": [ { "id": "Q8WMX8", "url": "https://omabrowser.org/oma/group/Q8WMX8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { 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"length": 1170, "header": "sp|Q95116-1|TSP2_BOVIN Isoform 1 of Thrombospondin-2 OS=Bos taurus OX=9913 GN=THBS2 PE=2 SV=2 CANONICAL=Q95116-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 1067, "start_aa": "Asn", "end_pos": 1067, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1067", "evidence": [ { "id": "Q95116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95116#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 151, "start_aa": "Asn", "end_pos": 151, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn151", "evidence": [ { "id": "Q95116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95116#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 316, "start_aa": "Asn", "end_pos": 316, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn316", "evidence": [ { "id": "Q95116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95116#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 330, "start_aa": "Asn", "end_pos": 330, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn330", "evidence": [ { "id": "Q95116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95116#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 455, "start_aa": "Asn", "end_pos": 455, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn455", "evidence": [ { "id": "Q95116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95116#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 582, "start_aa": "Asn", "end_pos": 582, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn582", "evidence": [ { "id": "Q95116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95116#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 708, "start_aa": "Asn", "end_pos": 708, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn708", "evidence": [ { "id": "Q95116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95116#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 936, "start_aa": "Asn", "end_pos": 936, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn936", "evidence": [ { "id": "Q95116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95116#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Opposite regulation of thrombospondin-1 and corticotropin-induced secreted protein/thrombospondin-2 expression by adrenocorticotropic hormone in adrenocortical cells.", "journal": "J. Cell. Physiol.", "date": "1996", "authors": "Lafeuillade B, Pellerin S, Keramidas M, Danik M, Chambaz E M, Feige J J", "evidence": [ { "database": "UniProtKB", "id": "Q95116", "url": "https://www.uniprot.org/uniprotkb/Q95116" } ], "reference": [ { "type": "PubMed", "id": "8698834", "url": "https://glygen.org/publication/PubMed/8698834" } ] } ], "pathway": [ { "id": "bta:338092", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:338092", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q95116", "url": "https://www.uniprot.org/uniprotkb/Q95116" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "Q95116", "url": "https://www.uniprot.org/uniprotkb/Q95116" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "Q95116", "url": "https://www.uniprot.org/uniprotkb/Q95116" } ], "pmid": "" }, { "name": "negative regulation of angiogenesis", "id": "GO:0016525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016525", "evidence": [ { "database": "UniProtKB", "id": "Q95116", "url": "https://www.uniprot.org/uniprotkb/Q95116" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "Q95116", "url": "https://www.uniprot.org/uniprotkb/Q95116" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": 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Exp. Med. Biol.", "date": "1997", "authors": "Muck S, Schr\u00f6r K", "evidence": [ { "database": "UniProtKB", "id": "Q95125", "url": "https://www.uniprot.org/uniprotkb/Q95125" } ], "reference": [ { "type": "PubMed", "id": "9561101", "url": "https://glygen.org/publication/PubMed/9561101" } ] } ], "pathway": [ { "id": "bta:538783", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538783", "resource": "KEGG Pathway" }, { "id": "R-BTA-391908", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-391908", "resource": "Reactome", "description": "Prostanoid ligand receptors" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" }, { "id": "R-BTA-416482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "resource": "Reactome", "description": "G alpha (12/13) signalling events" }, { "id": "R-BTA-428930", "name": "", "url": 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"annotation": "ADMA has potent adverse effects on cell proliferation, intracellular ROS generation, cell permeability, levels of ICAM-1, and the tight-junction protein occludin Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_776773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776773" }, { "database": "PubMed", "id": "21297899", "url": "https://glygen.org/publication/PubMed/21297899" } ] }, { "annotation": "Bovine Respiratory Syncytial Virus Decreased Pasteurella multocida Adherence by Downregulating the Expression of Intercellular Adhesion Molecule-1 on the Surface of Upper Respiratory Epithelial Cells.", "evidence": [ { "database": "RefSeq", "id": "NP_776773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776773" }, { "database": "PubMed", "id": "32605748", "url": "https://glygen.org/publication/PubMed/32605748" } ] }, { "annotation": "Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength. 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"crossref": [ { "id": "Q95LA0", "url": "https://alphafold.ebi.ac.uk/entry/Q95LA0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006820", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006820", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "281153", "url": "https://www.ncbi.nlm.nih.gov/gene/281153", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR039153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281153", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281153", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MEHGSQS", "url": "https://omabrowser.org/oma/group/MEHGSQS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q95LA0", "url": "https://www.orthodb.org/?gene=Q95LA0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21128", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21128", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21128:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21128:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05644", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05644", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_776477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776477", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q95LA0", "url": "https://www.uniprot.org/uniprotkb/Q95LA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q95LA0-1", "url": "https://www.uniprot.org/uniprotkb/Q95LA0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGGAVPNLKEKMQVPKDEDLLLGSFRDNQECSVAAEMKEHMSRLLGASQRRQRVDPKAVGSAVVWNTAANQSKKMGPQLRGVGVVGEQGDGGAQPQENPGGSQGMRSQFERRELNTLAEIGLEELNELEMEIMRRQLFMITERLRYLEDQSATWHQREVLLFTMLLSSCITNLWLWMRQ", "length": 180, "header": "sp|Q95LA0-1|FATE1_BOVIN Isoform 1 of Fetal and adult testis-expressed transcript protein homolog OS=Bos taurus OX=9913 GN=FATE1 PE=2 SV=1 CANONICAL=Q95LA0-1" }, "isoforms": [ { "isoform_ac": "Q95LA0-1", "url": "https://www.uniprot.org/uniprotkb/Q95LA0/entry#Q95LA0-1", "sequence": { "sequence": "MAGGAVPNLKEKMQVPKDEDLLLGSFRDNQECSVAAEMKEHMSRLLGASQRRQRVDPKAVGSAVVWNTAANQSKKMGPQLRGVGVVGEQGDGGAQPQENPGGSQGMRSQFERRELNTLAEIGLEELNELEMEIMRRQLFMITERLRYLEDQSATWHQREVLLFTMLLSSCITNLWLWMRQ", "length": 180, "header": "sp|Q95LA0-1|FATE1_BOVIN Isoform 1 of Fetal and adult testis-expressed transcript protein homolog OS=Bos taurus OX=9913 GN=FATE1 PE=2 SV=1 CANONICAL=Q95LA0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:281153", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281153", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q95LB4-1", "protein_name": "Fetal and adult testis-expressed transcript protein homolog", "gene_name": "FATE1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGGSTNTKKIEMSLAEELVPKSQEPSREQVLIAEMLEHGIRSLGASQSRQKLDSKISDSAAAWNLAANKSKKTGPQLPPKKASQEPNQEGGFQGMGFLYERNLGADVIAEIGLEELNGLEMEIMRRQLQVITGRLRALEDQGATWRHRETLFFTMLVSVCVANLWLWLRQ", "length": 171 }, "evidence": [ { "id": "Q95LA0", "url": "https://omabrowser.org/oma/group/Q95LA0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q969F0-1", "protein_name": "Fetal and adult testis-expressed transcript protein", "gene_name": "FATE1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGGPPNTKAEMEMSLAEELNHGRQGENQEHLVIAEMMELGSRSRGASQKKQKLEQKAAGSASAKRVWNMTATRPKKMGSQLPKPRMLRESGHGDAHLQEYAGNFQGIRFHYDRNPGTDAVAQTSLEEFNVLEMEVMRRQLYAVNRRLRALEEQGATWRHRETLIIAVLVSASIANLWLWMNQ", "length": 183 }, "evidence": [ { "id": "Q95LA0", "url": "https://omabrowser.org/oma/group/Q95LA0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of mitochondrial calcium ion concentration", "id": "GO:0051562", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051562", "evidence": [ { "database": "UniProtKB", "id": "Q95LA0", "url": "https://www.uniprot.org/uniprotkb/Q95LA0" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "Q95LA0", "url": "https://www.uniprot.org/uniprotkb/Q95LA0" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q95LA0", "url": "https://www.uniprot.org/uniprotkb/Q95LA0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "Q95LA0", "url": "https://www.uniprot.org/uniprotkb/Q95LA0" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q95LA0", "url": "https://www.uniprot.org/uniprotkb/Q95LA0" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q95LA0", "url": "https://www.uniprot.org/uniprotkb/Q95LA0" } ], "pmid": "" }, { "name": "mitochondria-associated endoplasmic reticulum membrane contact site", "id": "GO:0044233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044233", "evidence": [ { "database": "UniProtKB", "id": "Q95LA0", "url": "https://www.uniprot.org/uniprotkb/Q95LA0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "Q95LA0", "url": "https://www.uniprot.org/uniprotkb/Q95LA0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q95LA0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 180, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q95LA0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q95LA0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 71, "end_pos": 73 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", 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"phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QLW2-1", "uniprot_ac": "A6QLW2", "uniprot_id": "TGDS_BOVIN", "mass": { "chemical_mass": 40666.0, "monoisotopic_mass": 40666.0 }, "refseq": { "ac": "NP_001094629", "name": "UDP-D-glucose 4,6-dehydratase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094629" }, "gene_names": [ { "name": "TGDS", "type": "recommended", "evidence": [ { "id": "A6QLW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLW2" } ] }, { "name": "TGDS", "type": "synonym", "evidence": [ { "id": "NP_001094629", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094629" } ] } ], "protein_names": [ { "name": "UDP-D-glucose 4,6-dehydratase", "type": "recommended", "evidence": [ { "id": "A6QLW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLW2/entry#names_and_taxonomy" } ] }, { "name": "4.2.1.76", "type": "synonym", "evidence": [ { "id": "A6QLW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLW2/entry#names_and_taxonomy" } ] }, { "name": "UDP-D-glucose 4,6-dehydratase", "type": "synonym", "evidence": [ { "id": "NP_001094629", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094629" } ] }, { "name": "dTDP-D-glucose 4,6-dehydratase", "type": "synonym", "evidence": [ { "id": "NP_001094629", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094629" }, { "id": "A6QLW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLW2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "UDP-glucose 4,6-dehydratase that converts UDP-glucose into UDP-4-keto-6-deoxyglucose, and which is required for glycosaminoglycan biosynthesis and skeletal development (By similarity). UDP-4-keto-6-deoxyglucose is a mimic of the reaction intermediate of UXS1 and acts as an enzyme-rescue metabolite to promote the completion of UXS1 catalytic cycle when NAD(+) levels are low (By similarity). Under low NAD(+) conditions, UXS1 forms an inactive UDP-4-ketoxylose intermediate bound to NADH, impairing the synthesis of specific glycans that are essential for skeletal development (By similarity). UDP-4-keto-6-deoxyglucose is used by the inactive NADH-bound UXS1 to produce UDP-6-deoxyglucose and NAD(+) within the catalytic pocket of UXS1, regenerating the essential cofactor NAD(+) (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A6QLW2", "url": "https://www.uniprot.org/uniprotkb/A6QLW2#function" }, { "database": "UniProtKB", "id": "O95455", "url": "https://www.uniprot.org/uniprotkb/O95455#function" } ] }, { "annotation": "UTP-glucose 4,6-dehydratase that converts UDP-glucose into UDP-4-keto-6-deoxyglucose, and which is required for glycosaminoglycan biosynthesis and skeletal development. UDP-4-keto-6-deoxyglucose is a mimic of the reaction intermediate of UXS1 and acts as an enzyme-rescue metabolite to promote the completion of UXS1 catalytic cycle when NAD(+) levels are low. Under low NAD(+) conditions, UXS1 forms an inactive UDP-4-ketoxylose intermediate bound to NADH, impairing the synthesis of specific glycans that are essential for skeletal development. UDP-4-keto-6-deoxyglucose is used by the inactive NADH-bound UXS1 to produce UDP-6-deoxyglucose and NAD(+) within the catalytic pocket of UXS1, regenerating the essential cofactor NAD(+).", "evidence": [ { "database": "UniProtKB", "id": "A0A452DI65", "url": "https://www.uniprot.org/uniprotkb/A0A452DI65#function" }, { "database": "UniProtKB", "id": "ARBA00094174", "url": "https://www.uniprot.org/uniprotkb/ARBA00094174#function" }, { "database": "UniProtKB", "id": "A0A3Q1LGU2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGU2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QLW2", "url": "https://www.uniprot.org/uniprotkb/A6QLW2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TGDS", "url": "https://www.uniprot.org/uniprotkb/A6QLW2", "locus": { "chromosome": "12", "start_pos": 69075897, "end_pos": 69096584, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005309", "url": "https://www.ensembl.org/id/ENSBTAG00000005309" } ] } } ], "crossref": [ { "id": "A6QLW2", "url": "https://alphafold.ebi.ac.uk/entry/A6QLW2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005309", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005309", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05246", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05246", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534594", "url": "https://www.ncbi.nlm.nih.gov/gene/534594", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005888", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005888", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016040", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016040", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534594", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534594", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LGU2", "url": "https://www.orthodb.org/?gene=A0A3Q1LGU2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DI65", "url": "https://www.orthodb.org/?gene=A0A452DI65", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A6QLW2", "url": "https://www.orthodb.org/?gene=A6QLW2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43000", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43000", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16363", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16363", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001094629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094629", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "21500", "url": "https://www.rhea-db.org/rhea/21500", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LGU2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LGU2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGU2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DI65", "url": "https://www.uniprot.org/uniprotkb/A0A452DI65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DI65-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DI65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QLW2", "url": "https://www.uniprot.org/uniprotkb/A6QLW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QLW2-1", "url": "https://www.uniprot.org/uniprotkb/A6QLW2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVAGRAESLGPPDSFAKRVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDICDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKFIYVSTDEVYGGSLDKEFDESSPKQPTNPYASSKAAAECFVQSYWEQYKFPVVITRSSNVYGPHQYPEKVIPKFISLLQHNRKCCIHGTGLQTRNFLYATDVVEAFLTVLKKGKPGEIYNIGTNFEMSVLQLAKELIQLIKETNSESEMENWVDYVDDRPTNDMRYPMKSEKIHGLGWRPKVPWKEGIKKTIEWYRENFHNWKNAEKALEPFPVQPPFV", "length": 355, "header": "sp|A6QLW2-1|TGDS_BOVIN Isoform 1 of UDP-D-glucose 4,6-dehydratase OS=Bos taurus OX=9913 GN=TGDS PE=2 SV=1 CANONICAL=A6QLW2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LGU2-1", "url": "https://www.uniprot.org/uniprotkb/A6QLW2/entry#A0A3Q1LGU2-1", "sequence": { "sequence": "MVGWHHRLDGHEFEASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDICDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKFIYVSTDEVYGGSLDKEFDESSPKQPTNPYASSKAAAECFVQSYWEQYKFPVVITRSSNVYGPHQYPEKVIPKFISLLQHNRKCCIHGTGLQTRNFLYATDVVEAFLTVLKKGKPGEIYNIGTNFEMSVLQLAKELIQLIKETNSESEMENWVDYVDDRPTNDMRYPMKSEKIHGLGWRPKVPWKEGIKKTIEWYRENFHNWKNAEKALEPFPVQPPFV", "length": 340, "header": "tr|A0A3Q1LGU2-1|TGDS_BOVIN Computationally mapped isoform of UDP-D-glucose 4,6-dehydratase OS=Bos taurus OX=9913 GN=TGDS PE=2 SV=2 CANONICAL=A6QLW2-1" }, "locus": { "chromosome": "12", "start_pos": 69096356, "end_pos": 69077435, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068103.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068103.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057769.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057769.2" } ] } }, { "isoform_ac": "A0A452DI65-1", "url": "https://www.uniprot.org/uniprotkb/A6QLW2/entry#A0A452DI65-1", "sequence": { "sequence": "MSVAGRAESLGPPDSFAKRVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDICDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKFIYVSTDEVYGGSLDKEFDESSPKQPTNPYASSKAAAECFVQSYWEQYKFPVVITRSSNVYGPHQYPEKVIPKFISLLQHNRKCCIHGTGLQTRNFLYATDVVEAFLTVLKKGKPGEIYNIGTNFEMSVLQLAKELIQLIKETNSESEMENWVDYVDDRPTNDMRYPMKSEKIHGLGWRPKVPWKEGIKKTIPYPYPRSLLSF", "length": 339, "header": "tr|A0A452DI65-1|TGDS_BOVIN Computationally mapped isoform of UDP-D-glucose 4,6-dehydratase OS=Bos taurus OX=9913 GN=TGDS PE=2 SV=1 CANONICAL=A6QLW2-1" }, "locus": { "chromosome": "12", "start_pos": 69095829, "end_pos": 69077435, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006984.5", "url": "https://www.ensembl.org/id/ENSBTAT00000006984.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006984.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006984.5" } ] } }, { "isoform_ac": "A0AAA9SIP1-1", "url": "https://www.uniprot.org/uniprotkb/A6QLW2/entry#A0AAA9SIP1-1", "sequence": { "sequence": "MSVAGRAESLGPPDSFAKRVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKGDICDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKFIYVSTDEVYGGSLDKEFDESSPKQPTNPYASSKAAAECFVQSYWEQYKFPVVITRSSNVYGPHQYPEKVIPKFISLLQHNRKCCIHGTGLQTRNFLYATDVVEAFLTVLKKGKPGEIYNIGTNFEMSVLQLAKELIQLIKETNSESEMENWVDYVDDRPTNDMRYPMKSEKIHGLGWRPKVPWKEGIKKTIEWYRENFHNWKNAEKALEPFPVQPPFV", "length": 332, "header": "tr|A0AAA9SIP1-1|TGDS_BOVIN Computationally mapped isoform of UDP-D-glucose 4,6-dehydratase OS=Bos taurus OX=9913 GN=TGDS PE=2 SV=1 CANONICAL=A6QLW2-1" }, "locus": { "chromosome": "12", "start_pos": 69095829, "end_pos": 69077435, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104067.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104067.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083636.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083636.1" } ] } }, { "isoform_ac": "A6QLW2-1", "url": "https://www.uniprot.org/uniprotkb/A6QLW2/entry#A6QLW2-1", "sequence": { "sequence": "MSVAGRAESLGPPDSFAKRVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDICDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKFIYVSTDEVYGGSLDKEFDESSPKQPTNPYASSKAAAECFVQSYWEQYKFPVVITRSSNVYGPHQYPEKVIPKFISLLQHNRKCCIHGTGLQTRNFLYATDVVEAFLTVLKKGKPGEIYNIGTNFEMSVLQLAKELIQLIKETNSESEMENWVDYVDDRPTNDMRYPMKSEKIHGLGWRPKVPWKEGIKKTIEWYRENFHNWKNAEKALEPFPVQPPFV", "length": 355, "header": "sp|A6QLW2-1|TGDS_BOVIN Isoform 1 of UDP-D-glucose 4,6-dehydratase OS=Bos taurus OX=9913 GN=TGDS PE=2 SV=1 CANONICAL=A6QLW2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:534594", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534594", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A6QLW2", "url": "https://www.uniprot.org/uniprotkb/A6QLW2" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A6QLW2", "url": "https://www.uniprot.org/uniprotkb/A6QLW2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "glycosaminoglycan biosynthetic process", "id": "GO:0006024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006024", "evidence": [ { "database": "UniProtKB", "id": "A6QLW2", "url": "https://www.uniprot.org/uniprotkb/A6QLW2" } ], "pmid": "" }, { "name": "nucleotide-sugar metabolic process", "id": "GO:0009225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009225", "evidence": [ { "database": "UniProtKB", "id": "A6QLW2", "url": "https://www.uniprot.org/uniprotkb/A6QLW2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "dTDP-glucose 4,6-dehydratase activity", "id": "GO:0008460", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008460", "evidence": [ { "database": "UniProtKB", "id": "A6QLW2", "url": "https://www.uniprot.org/uniprotkb/A6QLW2" } ], "pmid": "" }, { "name": "UDP-glucose 4,6-dehydratase activity", "id": "GO:0050377", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050377", "evidence": [ { "database": "UniProtKB", "id": "A6QLW2", "url": "https://www.uniprot.org/uniprotkb/A6QLW2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21500", "name": "", "equation": "UDP-alpha-D-glucose = UDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A6QLW2-1" ], "evidence": [ { "id": "21500", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21500" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A6QLW2", "gene_name": "TGDS", "activity": [ { "ec_number": "4.2.1.76", "activity": "UDP-alpha-D-glucose = UDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O.", "evidence": [ { "id": "A6QLW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLW2" } ] }, { "ec_number": "4.2.1.76", "activity": "", "evidence": [ { "id": "A6QLW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLW2" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QLW2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 355, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QLW2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QLW2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "4.2.1.76", "ec_name": "UDP-alpha-D-glucose = UDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O.", "evidence": [ { "id": "4.2.1.76", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.76" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QP75-1", "uniprot_ac": "A6QP75", "uniprot_id": "AL2CL_BOVIN", "mass": { "chemical_mass": 107869.0, "monoisotopic_mass": 107869.0 }, "refseq": { "ac": "NP_001095958", "name": "ALS2 C-terminal-like protein", "summary": "", "url": 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Regulates the ALS2-mediated endosome dynamics (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A6QP75", "url": "https://www.uniprot.org/uniprotkb/A6QP75#function" }, { "database": "UniProtKB", "id": "A0A3Q1LIF8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIF8#function" }, { "database": "UniProtKB", "id": "ARBA00057510", "url": "https://www.uniprot.org/uniprotkb/ARBA00057510#function" }, { "database": "UniProtKB", "id": "A0A3Q1M2N1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2N1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QP75", "url": "https://www.uniprot.org/uniprotkb/A6QP75" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ALS2CL", "url": "https://www.uniprot.org/uniprotkb/A6QP75", "locus": { "chromosome": "22", "start_pos": 52815790, "end_pos": 52793642, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017812", "url": "https://www.ensembl.org/id/ENSBTAG00000017812" } ] } } ], "crossref": [ { "id": "A6QP75", "url": "https://alphafold.ebi.ac.uk/entry/A6QP75", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017812", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017812", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506969", "url": "https://www.ncbi.nlm.nih.gov/gene/506969", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037191", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037191", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051984", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051984", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057248", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057248", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506969", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506969", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HWQEGSM", "url": "https://omabrowser.org/oma/group/HWQEGSM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QP75", "url": "https://www.orthodb.org/?gene=A6QP75", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46089", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46089", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46089:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46089:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02204", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02204", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02493", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02493", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25383", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25383", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001095958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095958", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LIF8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIF8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LIF8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIF8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2N1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2N1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2N1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2N1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QP75", "url": "https://www.uniprot.org/uniprotkb/A6QP75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QP75-1", "url": "https://www.uniprot.org/uniprotkb/A6QP75-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCSPEEAALLRLEEVFSATLARINSLVFQPLLEAGPEASDPWGRECLQLLQQLHSSSQQLWDVMEESLHSLRERLRRPEAVGLESLLLLQSADRVLQVHLEYIESYTCCVAVQAFQKAVKRRSEYWRGQRKALRQVLSGLSSEGSVGTALLQALRQPLAHHVQQYVLLLLSLGDTVGECHPTRELVIHAASLFGDLQSFMRQELDQATATQALWPTLSSRLRDVLCTPARRLLQDSQDVPVTVTPLRAERVLLFDDALVLLQGHNIHTFDLKLVWVEPGQDRCTFHLLTPEEGFSFCSKDPQGLVVWQWKVTQAVCQALRGKKDFPVLGAGLEPSEPPTCRCGAYTFHAEGRFCQATYEGEWYWGRPHGKGTLKWPDGRNHVGDFCQGLEHGFGIRLVPQASEDKFDCYKCHWWEGSMCGYGICEYSTSEVYKGYFQEGLRHGFGVLESAPQAPRPLRYTGHWERGQRSGYGVEEDSDRGERYIGMWQADQRHGPGVMVTQAGVCYQGTFQADKMVGPGILLSDDDSLYEGTFTRDLTLVGKGKVTFPNGFTLEGSFGSVSGRGLHTQGVLDTAALPPDPSSTCKRQLGQGVFPVESRWQGVYGAFRDFVRAGCPGDLREALLGFHVQSSRELRKSQEYLCCERTCPEDQAGRMEDLLEELLQHREPEALQQCLRKALSNSLHPLGKLLRTLMLTFQATYAGIGANKHLQGLAQEEVKQHAQELWAAYRGLLQVALQRKGQAPEEDEDAETRDLRVHSLVLPLVLPSFYSELFTLYLLLHEREDSLYSQGITHLSLFPDARLLEFLDVQKHLWPLKDLTLTTNQRYSLVRDKCFLSATECLQKMITTVDPREKLEVLERTYGEIEATVSRVLGREHKLPMDDLLPLLIYVVSRAQIQHLGAEIHLIRDMMDPLHTGGLYDFLLTALESCYEHIQKEDMRLHRLPSRWSSREPW", "length": 953, "header": "sp|A6QP75-1|AL2CL_BOVIN Isoform 1 of ALS2 C-terminal-like protein OS=Bos taurus OX=9913 GN=ALS2CL PE=2 SV=1 CANONICAL=A6QP75-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LIF8-1", "url": "https://www.uniprot.org/uniprotkb/A6QP75/entry#A0A3Q1LIF8-1", "sequence": { "sequence": "MCSPEEAALLRLEEVFSATLARINSLVFQPLLEAGPEASDPWGRECLQLLQQLHSSSQQLWDVMEESLHSLRERLRRPEAVGLESLLLLQSADRVLQVHLEYIESYTCCVAVQAFQKAVKRRSEYWRGQRKALRQVLSGLSSEGSVGTALLQALRQPLAHHVQQYVLLLLSLGDTVGEVGRYRCLPDLLFGDLQSFMRQELDQATATQALWPTLSSRLRDVLCTPARRLLQDSQDVPVTVTPLRAERVLLFDDALVLLQGHNIHTFDLKLVWVEPGQDRCTFHLLTPEEGFSFCSKDPQGLVVWQWKVTQAVCQALRGKKDFPVLGAGLEPSEPPTCRCGAYTFHAEGRFCQATYEGEWYWGRPHGKGTLKWPDGRNHVGDFCQGLEHGFGIRLVPQASEDKFDCYKCHWWEGSMCGYGICEYSTSEVYKGYFQEGLRHGFGVLESAPQAPRPLRYTGHWERGQRSGYGVEEDSDRGERYIGMWQADQRHGPGVMVTQAGVCYQGTFQADKMVGPGILLSDDDSLYEGTFTRDLTLVGKGKVTFPNGFTLEGSFGSVSGRGLHTQGVLDTAALPPDPSSTCKRQLGQGVFPVESRWQGVYGAFRDFVRAGCPGDLREALLGFHVQSSRELRKSQEYLCCERTCPEDQAGRMEDLLEELLQHREPEALQQCLRKALSNSLHPLGKLLRTLMLTFQATYAGIGANKHLQGLAQEEVKQHAQELWAAYRGLLQVALQRKGQAPEEDEDAETRDLRVHSLVLPLVLPSFYSELFTLYLLLHEREDSLYSQGITHLSLFPDARLLEFLDVQKHLWPLKDLTLTTNQRYSLVRDKCFLSATECLQKMITTVDPREKLEVLERTYGEIEATVSRVLGREHKLPMDDLLPLLIYVVSRAQIQHLGAEIHLIRDMMDPLHTGGLYDFLLTALESCYEHIQKEDMRLHRLPSRWSSREPW", "length": 950, "header": "tr|A0A3Q1LIF8-1|AL2CL_BOVIN Computationally mapped isoform of ALS2 C-terminal-like protein OS=Bos taurus OX=9913 GN=ALS2CL PE=2 SV=1 CANONICAL=A6QP75-1" }, "locus": { "chromosome": "22", "start_pos": 52815400, "end_pos": 52798055, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072632.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072632.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058809.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058809.1" } ] } }, { "isoform_ac": "A0A3Q1M2N1-1", "url": "https://www.uniprot.org/uniprotkb/A6QP75/entry#A0A3Q1M2N1-1", "sequence": { "sequence": "MGFSRPESGTLAMCSPEEAALLRLEEVFSATLARINSLVFQPLLEAGELRLSSEKGPEASDPWGRECLQLLQQLHSSSQQLWDVMEESLHSLRERLRRPEAVGLESLLLLQSADRVLQVHLEYIESYTCCVAVQAFQKAVKRRSEYWRGQRKALRQVLSGLSSEGSVGTALLQALRQPLAHHVQQYVLLLLSLGDTVGECHPTRELVIHAASLFGDLQSFMRQELDQATATQALWPTLSSRLRDVLCTPARRLLQDSQDVPVTVTPLRAERVLLFDDALVLLQGHNIHTFDLKLVWVEPGQDRCTFHLLTPEEGFSFCSKDPQGLVVWQWKVTQAVCQALRGKKDFPVLGAGLEPSEPPTCRCGAYTFHAEGRFCQATYEGEWYWGRPHGKGTLKWPDGRNHVGDFCQGLEHGFGIRLVPQASEDKFDCYKCHWWEGSMCGYGICEYSTSEVYKGYFQEGLRHGFGVLESAPQAPRPLRYTGHWERGQRSGYGVEEDSDRGERYIGMWQADQRHGPGVMVTQAGVCYQGTFQADKMVGPGILLSDDDSLYEGTFTRDLTLVGKGKVTFPNGFTLEGSFGSVSGRGLHTQGVLDTAALPPDPSSTCKRQLGQGVFPVESRWQGVYGAFRDFVRAGCPGDLREALLGFHVQSSRELRKSQEYLCCERTCPEDQAGRMEDLLEELLQHREPEALQQCLRKALSNSLHPLGKLLRTLMLTFQATYAGIGANKHLQGLAQEEVKQHAQELWAAYRGLLQVALQRKGQAPEEDEDAETRDLRVHSLVLPLVLPSFYSELFTLYLLLHEREDSLYSQGITHLSLFPDARLLEFLDVQKHLWPLKDLTLTTNQRYSLVRDKCFLSATECLQKMITTVDPREKLEVLERTYGEIEATVSRVLGREHKLPMDDLLPLLIYVVSRAQIQHLGAEIHLIRDMMDPLHTGGLYDFLLTALESCYEHIQKEDMRLHRLPSRWSSREPW", "length": 974, "header": "tr|A0A3Q1M2N1-1|AL2CL_BOVIN Computationally mapped isoform of ALS2 C-terminal-like protein OS=Bos taurus OX=9913 GN=ALS2CL PE=2 SV=2 CANONICAL=A6QP75-1" }, "locus": { "chromosome": "22", "start_pos": 52815400, "end_pos": 52795870, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073069.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073069.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067689.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067689.2" } ] } }, { "isoform_ac": "A6QP75-1", "url": "https://www.uniprot.org/uniprotkb/A6QP75/entry#A6QP75-1", "sequence": { "sequence": "MCSPEEAALLRLEEVFSATLARINSLVFQPLLEAGPEASDPWGRECLQLLQQLHSSSQQLWDVMEESLHSLRERLRRPEAVGLESLLLLQSADRVLQVHLEYIESYTCCVAVQAFQKAVKRRSEYWRGQRKALRQVLSGLSSEGSVGTALLQALRQPLAHHVQQYVLLLLSLGDTVGECHPTRELVIHAASLFGDLQSFMRQELDQATATQALWPTLSSRLRDVLCTPARRLLQDSQDVPVTVTPLRAERVLLFDDALVLLQGHNIHTFDLKLVWVEPGQDRCTFHLLTPEEGFSFCSKDPQGLVVWQWKVTQAVCQALRGKKDFPVLGAGLEPSEPPTCRCGAYTFHAEGRFCQATYEGEWYWGRPHGKGTLKWPDGRNHVGDFCQGLEHGFGIRLVPQASEDKFDCYKCHWWEGSMCGYGICEYSTSEVYKGYFQEGLRHGFGVLESAPQAPRPLRYTGHWERGQRSGYGVEEDSDRGERYIGMWQADQRHGPGVMVTQAGVCYQGTFQADKMVGPGILLSDDDSLYEGTFTRDLTLVGKGKVTFPNGFTLEGSFGSVSGRGLHTQGVLDTAALPPDPSSTCKRQLGQGVFPVESRWQGVYGAFRDFVRAGCPGDLREALLGFHVQSSRELRKSQEYLCCERTCPEDQAGRMEDLLEELLQHREPEALQQCLRKALSNSLHPLGKLLRTLMLTFQATYAGIGANKHLQGLAQEEVKQHAQELWAAYRGLLQVALQRKGQAPEEDEDAETRDLRVHSLVLPLVLPSFYSELFTLYLLLHEREDSLYSQGITHLSLFPDARLLEFLDVQKHLWPLKDLTLTTNQRYSLVRDKCFLSATECLQKMITTVDPREKLEVLERTYGEIEATVSRVLGREHKLPMDDLLPLLIYVVSRAQIQHLGAEIHLIRDMMDPLHTGGLYDFLLTALESCYEHIQKEDMRLHRLPSRWSSREPW", "length": 953, "header": "sp|A6QP75-1|AL2CL_BOVIN Isoform 1 of ALS2 C-terminal-like protein OS=Bos taurus OX=9913 GN=ALS2CL PE=2 SV=1 CANONICAL=A6QP75-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506969", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506969", "resource": "KEGG Pathway" }, { "id": "R-BTA-8876198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "resource": "Reactome", "description": "RAB GEFs exchange GTP for GDP on RABs" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZG75-1", "protein_name": "ALS2 C-terminal-like protein", "gene_name": "Als2cl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCSSEETDLLRLEEVFSTTLARTISLILQPLLLADPEPSDPCGKECLRLLQQLHESAQRLWDVTEQSLLSLRQRLYHPPSMSLEAVLLLNNADYVLQAHMEYIKSYTDCLVVQAFQKVSKKRSEFWRSQRKALRQLLSSGSSEGSVGTTLCQALRQPLAHHVQKYVLLLLSLRDTLDEHHPAQQLVMHAVTLFGNLQSFMQQALDQAMATQALWHSLSSRLRDVLCTPTHRLLQDSQDIPVVVTPLRAERVLLFDDTLVLLQGHNVHTFDLKLVWVDPSQDKCVLHILTPEDEFSFCTRDPQGQVVWQWKVTQAVCQALCGKKDFPVLGSGREPSVPPECRCLAYTFHREGRLYQATYDGEWSRAKPHGKGTLKWPDGRNHVGDFYQGLEHGFGICLVPQASEDKFDCYKCHWREGRMCEYGICEYGTDEVYKGYFQAGVRHGFGVLDSAPQAPQPFRYTGHWERGQRSGYGIEEDRDRGERYIGMWQADQRHGPGIVVTQAGVCYQGTFQGDKMAGPGILLCEDDSLYEGTFTRELTLLGKGKVTFPNGFTLEGSFCSGTDKGLYTQGVLDTTALPPNPSSTRKRQLGLGAFPVESRWQGVYSPFRDFLRLGCPGELQEALLGFHVQSSRELRKSQEYLCCERSHPKDCVGSMEDILKELLQHRKPKALQQYLRKALSNSRHPLGKLLQTLMLTFQATYSGIGANKHLQAMAQEEVKQHARELWAAYRGLLKVALLRQGQTLEEESMETRDLQVHGLLLPLLLPSFYSELFTLYLLLHEREDGLYSRGIANLSLFPDTKLLEFLDVQKHLWPLKDLRLTSNQRYSLVRDKCFLSATECLQKIITTVDPREKLEVLEKTYGEIEATVSRVLGREYKLPMDDLLPLLIYVVSRARIQHLGAEIHLIRDMMDPIHTGGLHDFLLTALESCYEHIQKEDMRLHHLPGHWDARELW", "length": 952 }, "evidence": [ { "id": "A6QP75", "url": "https://omabrowser.org/oma/group/A6QP75/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LJK1-1", "protein_name": "ALS2 C-terminal-like protein", "gene_name": "ALS2CL", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MCSPEEEALLQLEEVFSVTLDHINNLVLQPLLKAAAEPSDPWGRECLSLLQQLHRSSRRLWEVTKESLHSLQERLHHPDSFGLEALLLLHSADHILQIHIEYIESYTSCVVVNVFQKAAKRRSEYWRAQRKMLQQFLSGMSSAGSVGTVLVQALHQPLAHHVQQYVFFLLSLADTIGEHHPSRELVVHAAELFGNLQSFMSQELDQAMATQALRHTLSSRVGDVLCTPSRRLLQDSQDIPVTVTPLRSERVLLFDDSLVLLQGHSVHTFDLKLVWVEPGQDGCMFHLLTPEEKFFFCSKDPQGRVVWQWKVTQAVCQALRGKKDFPLLGAGLKPSETPSCRCGAYTFLSEGRFCQATYEGEWYWGKPHGKGTLKWPDGRNHVGEFCQGLEHGFGIRLVPQASEDKFDCYKCHWREGSMCGYGICENGTSEVYKGYFQEGLRHGFGVLESTPQAPQSCRYTGHWEKGQRSGYGIAEDSDRGERYIGMWQADQRHGPGIIVTQAGVCFQGTFQADKMVGPGILLSEDDSLYEGTFTRDLTLLGKGKVTFPNGFTLEGSFGSGAGGGLHTQGVLDTAGLPPDPGSTRKRQLGLGAFPVESRWQGICGPFQDFVRAGCPGDLQEALLGFHVQSSKELRKSQEYLCCERTHPEDHTGRMEDILEELLQHREPEALQQCLRKALTNSLHPLGKLLRTLMLTFQATYTGIGANKHLQGLAQEEVKQHAQEIWAAYRGLLQVALQRKGQALEEAEDAETRDLQVHGLVLPLVLPSFYSELFTLYLLLHEREDSLYSQGIISLSLFPDTKLLEFLDVQKHLWPLKDLTLTTNQRYSLVRDKCFLSATECLQKMITTVDPREKLEVLERTYGEIEATVSRVLGQEYKLPMDDLLPLLIYVVSRARIQHLGAEIHLIRDMMDPIHTGGLYDFLLTALESCYEHIQKEDMRLDRLPRRWDLREPW", "length": 953 }, "evidence": [ { "id": "A6QP75", "url": "https://omabrowser.org/oma/group/A6QP75/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q60I26-1", "protein_name": "ALS2 C-terminal-like protein", "gene_name": "Als2cl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSSEEADLLRLEEVFSTTLARTISLILQPLLLADPEPSDPCGKECLRLLQQLHESAQRLWYVTEQSLLSLRQRLYHPPSKGLEAVLLLSNADHVLQAHMEYIKSYTDCVVAQAFQKVSKKRSEFWRSQRKALRQLLSSGSSEGSVGTTMCQALRQPLSQHVQKYLLLLLSLRDTLDESHPAQELVMHAITLFGNLQSFMGQALDQAVATQALWHSLSSRLRDVLCSPAHRLLQDSQDIPVVVTPLRAERVLLFDDSLVLLQGHNTHTFDLKLVWVKPGQDKCVLHILTPEEEISFCTRDPQGQVVWQWKVTQAVCQALCGKKDFPVLGSGRETSVPPECRCVAYTFCREGRLCQATYDGEWCRAKPHGKGTLKWPDGRNHVGTFYQGLEHGFGICLVPQASEDKFDCYKCHWREGRMCEYGICEYGTDEVYKGYFQAGLRHGFGILESAPQAPQPFRYTGHWERGQRSGYGIEEDRDRGERYIGMWQADQRHGPGVVVTQAGVCYQGTFQGDKMAGPGILLCEDDSLYEGTFTRDLTLLGKGKVTFPNGFTLDGSFSSGTDKGLYTQGVLDTAALPPDPSSTRKRQLGLGTFPVESRWQGVYSPFRDFLRLGCPGEQQEALLGFHTQSSRELRKSQECLCCERSHPEDCVGSMEDTLKELLQHRKPKALQQYLRKALSNSRHPLGQLLRTLMLTFQATYSGIGANKHLQEMAQEEVKQHARELWAAYRGLLKVALQHQGQTLEEENMETRDLQVHGLLLPLILPSFYSELFTLYLLLHEREDGLYSRGITNLSLFPDTKLLEFLDVQKHLWPLKDLKLTSNQRYSLVRDKCFLTATECLQKIITTVHPREKLEVLEKTYGEIEATVSRVLGCKYKLPMDDLLPLLIYVVSRARIQHLGAEIHLIRDMMDPVHTGGLHDFLLTALESCYEHIQKEDMRPHHLPGHWDARDLW", "length": 952 }, "evidence": [ { "id": "A6QP75", "url": "https://omabrowser.org/oma/group/A6QP75/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q60I27-1", "protein_name": "ALS2 C-terminal-like protein", "gene_name": "ALS2CL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MCNPEEAALLRLEEVFSATLAHVNSLVLQPLLPAAPDPSDPWGRECLRLLQQLHKSSQQLWEVTEESLHSLQERLRYPDSTGLESLLLLRGADRVLQAHIEYIESYTSCMVVQAFQKAAKRRSEYWRGQRKALRQLLSGVSSEGSVGASLGQALHQPLAHHVQQYVLLLLSLGDTIGEHHPTRELVVNAVTLFGNLQSFMKQELDQAVATQALWHTLRGRLRDVLCTPAHRLLQDSQDVPVTVAPLRAERVLLFDDALVLLQGHNVHTFDLKLVWVDPGQDGCTFHLLTPEEEFSFCAKDSQGQAVWQWKVTWAVHQALHGKKDFPVLGAGLEPSQPPDCRCAEYTFQAEGRLCQATYEGEWCRGRPHGKGTLKWPDGRNHVGNFCQGLEHGFGIRLLPQASEDKFDCYKCHWREGSMCGYGICEYSTDEVYKGYFQEGLRHGFGVLESGPQAPQPFRYTGHWERGQRSGYGIEEDGDRGERYIGMWQAGQRHGPGVMVTQAGVCYQGTFQADKTVGPGILLSEDDSLYEGTFTRDLTLMGKGKVTFPNGFTLEGSFGSGAGRGLHTQGVLDTAALPPDPSSTCKRQLGVGAFPVESRWQGVYSPFRDFVCAGCPRDLQEALLGFDVQSSRELRRSQDYLSCERTHPEDSVGSMEDILEELLQHREPKALQLYLRKALSNSLHPLGKLLRTLMLTFQATYAGVGANKHLQELAQEEVKQHAQELWAAYRGLLRVALERKGQALEEDEDTETRDLQVHGLVLPLMLPSFYSELFTLYLLLHEREDSFYSQGIANLSLFPDTQLLEFLDVQKHLWPLKDLTLTSNQRYSLVRDKCFLSATECLQKIMTTVDPREKLEVLERTYGEIEGTVSRVLGREYKLPMDDLLPLLIYVVSRARIQHLGAEIHLIRDMMDPNHTGGLYDFLLTALESCYEHIQKEDMRLHRLPGHWHSRELW", "length": 953 }, "evidence": [ { "id": "A6QP75", "url": "https://omabrowser.org/oma/group/A6QP75/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A6QP75", "url": "https://www.uniprot.org/uniprotkb/A6QP75" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A6QP75", "url": "https://www.uniprot.org/uniprotkb/A6QP75" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A6QP75", "url": "https://www.uniprot.org/uniprotkb/A6QP75" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A6QP75", "url": "https://www.uniprot.org/uniprotkb/A6QP75" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A6QP75", "url": "https://www.uniprot.org/uniprotkb/A6QP75" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "endosomal transport", "id": "GO:0016197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016197", "evidence": [ { "database": "UniProtKB", "id": "A6QP75", "url": "https://www.uniprot.org/uniprotkb/A6QP75" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QP75-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 953, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QP75-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QP75" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A6QP75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP75" }, { "id": "PRU00550", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00550" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VPS9", "eco_id": "ECO_0000255", "start_pos": 796, "end_pos": 942, "start_aa": "Leu", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 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}, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { 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"evidence": [ { "id": "NP_001095977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095977" } ] } ], "protein_names": [ { "name": "Constitutive coactivator of peroxisome proliferator-activated receptor gamma", "type": "recommended", "evidence": [ { "id": "A6QNT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNT4/entry#names_and_taxonomy" } ] }, { "name": "Constitutive coactivator of PPAR-gamma", "type": "synonym", "evidence": [ { "id": "A6QNT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNT4/entry#names_and_taxonomy" } ] }, { "name": "Constitutive coactivator of PPARG", "type": "synonym", "evidence": [ { "id": "A6QNT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNT4/entry#names_and_taxonomy" } ] }, { "name": "Protein FAM120B", "type": "synonym", "evidence": [ { "id": "A6QNT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNT4/entry#names_and_taxonomy" } ] }, { "name": "constitutive coactivator of PPAR-gamma", "type": "synonym", "evidence": [ { "id": "NP_001095977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095977" } ] }, { "name": "constitutive coactivator of PPARG", "type": "synonym", "evidence": [ { "id": "NP_001095977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095977" } ] }, { "name": "constitutive coactivator of peroxisome proliferator-activated receptor gamma", "type": "synonym", "evidence": [ { "id": "NP_001095977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095977" } ] } ], "function": [ { "annotation": "Functions as a transactivator of PPARG and ESR1. 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"categories": [ "Genome Annotation" ] }, { "id": "IPR026784", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026784", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524306", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524306", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A6QNT4", "url": "https://www.orthodb.org/?gene=A6QNT4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G5E564", "url": "https://www.orthodb.org/?gene=G5E564", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15976", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15976", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15976:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15976:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27242", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27242", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095977", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRQ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW06", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW06-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S209", 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"categories": [ "Protein" ] } ], "sequence": { "sequence": "MGVRGLHGFVASSCPHVCTVVNFKELAERHRSQHPGGTPTIVVDAMCCLRYWYTPESWVCGGQWREYYSSLREFVRTFTAVGIKLIFFFDGMVEQSKRDEWVKRRLKNNREIAKIFHYIKSRREQPGRNMFFIPSGLAIFTRFALKALGQETLCSLQEADYEVASYGFQNNCLGILGEDTDYLIYDTCPYFSISELSLDSLDTVMLCREKLCQSLGLHLADLPLLACLLGNDVIPEGMFESFRYKCLTSYASVRESCDRKGNVILAVAEHISKVLRLHQGEKKLEEMLPLGPNKALFYKGVASYLLPGQKSPWFIQKPEDVVTLDKQVLSMSSDPESKQEFPVCMDSESKQKLPVGTDPEFNLEAPMCTNTEVKQEDPVNVGPEAKHQVTVVLDPEILKVARAQHVQAESYLVYSVMSSGEVECSNSLEDATDQALPSQAFVYRPVRQRVYSLLLGGGGGGSSTGPAVKEWFVYSGNPLRQPDLVRPLQMNIPGGTPSLRQLWLSQEPGIQAQRLDTLLACFDLSSSREELQAVERPFQALCCLLVYLFVQVDTLCLEDLHAFIAQALCLQGKPTMELADLQLDHIDPRAVQLATLLVRGLTTLVLVNGACGSPWEMADFMPWHLFDGKLFHQKYLQSEKGYTAEVLVEQNRSHVTRFHTLKSVVCKACGKESRPIVSRRHWRPHHAGSRQYEPDQWRRY", "length": 700, "header": "sp|A6QNT4-1|F120B_BOVIN Isoform 1 of Constitutive coactivator of peroxisome proliferator-activated receptor gamma OS=Bos taurus OX=9913 GN=FAM120B PE=2 SV=1 CANONICAL=A6QNT4-1" }, "isoforms": [ { "isoform_ac": 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OX=9913 GN=FAM120B PE=2 SV=1 CANONICAL=A6QNT4-1" }, "locus": { "chromosome": "9", "start_pos": 104009302, "end_pos": 103961339, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106234.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106234.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076114.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076114.1" } ] } }, { "isoform_ac": "A0AAA9TA56-1", "url": "https://www.uniprot.org/uniprotkb/A6QNT4/entry#A0AAA9TA56-1", "sequence": { "sequence": "MGVRGLHGFVASSCPHVCTVVNFKELAERHRSQHPGGTPTIVVDAMCCLRYWYTPESWVCGGQWREYYSSLREFVRTFTAVGIKLIFFFDGMVEQSKRDEWVKRRLKNNREIAKIFHYIKSRREQPGRNMFFIPSGLAIFTRFALKALGQETLCSLQEADYEVASYGFQNNCLGILGEDTDYLIYDTCPYFSISELSLDSLDTVMLCREKLCQSLGLHLADLPLLACLLGNDVIPEGMFESFRYKCLTSYASVRESCDRKGNVILAVAEHISKVLRLHQGEKKLEEMLPLGPNKALFYKGVASYLLPGQKSPWFIQKPEDVVTLDKQVLSMSSDPESKQEFPVCMDSESKQKLPVGTDPEFNLEAPMCTNTEVKQEDPVNVGPEAKHQVTVVLDPEILKVARAQHVQAESYLVYSVMSSGEVECSNSLEDATDQALPSQAFVYRPVRQRVYSLLLGGGGGGSSTGPAVKEWFVYSGNPLRQPDLVRPLQMNIPGGTPSLRQLWLSQEPGIQAQRLDTLLACFDLSSSREELQAVERPFQALCCLLVYLFVQVDTLCLEDLHAFIAQALCLQGKPTMELADLQLDHIDPRAVQLATLLVRGLTTLVLVNGACGSPWEMADFMPWHLFDGKLFHQKYLQSEKGYTAEVLVEQNRSHVTRFHTLKSVVCKACGKESRPIVSRRHWRPHHAGQS", "length": 690, "header": "tr|A0AAA9TA56-1|F120B_BOVIN Computationally mapped isoform of Constitutive coactivator of peroxisome proliferator-activated receptor gamma OS=Bos taurus OX=9913 GN=FAM120B PE=2 SV=2 CANONICAL=A6QNT4-1" }, "locus": { "chromosome": "9", "start_pos": 104010341, "end_pos": 103961339, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123330.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123330.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093761.2", "url": "https://www.ensembl.org/id/ENSBTAP00000093761.2" } ] } }, { "isoform_ac": "A6QNT4-1", "url": "https://www.uniprot.org/uniprotkb/A6QNT4/entry#A6QNT4-1", "sequence": { "sequence": "MGVRGLHGFVASSCPHVCTVVNFKELAERHRSQHPGGTPTIVVDAMCCLRYWYTPESWVCGGQWREYYSSLREFVRTFTAVGIKLIFFFDGMVEQSKRDEWVKRRLKNNREIAKIFHYIKSRREQPGRNMFFIPSGLAIFTRFALKALGQETLCSLQEADYEVASYGFQNNCLGILGEDTDYLIYDTCPYFSISELSLDSLDTVMLCREKLCQSLGLHLADLPLLACLLGNDVIPEGMFESFRYKCLTSYASVRESCDRKGNVILAVAEHISKVLRLHQGEKKLEEMLPLGPNKALFYKGVASYLLPGQKSPWFIQKPEDVVTLDKQVLSMSSDPESKQEFPVCMDSESKQKLPVGTDPEFNLEAPMCTNTEVKQEDPVNVGPEAKHQVTVVLDPEILKVARAQHVQAESYLVYSVMSSGEVECSNSLEDATDQALPSQAFVYRPVRQRVYSLLLGGGGGGSSTGPAVKEWFVYSGNPLRQPDLVRPLQMNIPGGTPSLRQLWLSQEPGIQAQRLDTLLACFDLSSSREELQAVERPFQALCCLLVYLFVQVDTLCLEDLHAFIAQALCLQGKPTMELADLQLDHIDPRAVQLATLLVRGLTTLVLVNGACGSPWEMADFMPWHLFDGKLFHQKYLQSEKGYTAEVLVEQNRSHVTRFHTLKSVVCKACGKESRPIVSRRHWRPHHAGSRQYEPDQWRRY", "length": 700, "header": "sp|A6QNT4-1|F120B_BOVIN Isoform 1 of Constitutive coactivator of peroxisome proliferator-activated receptor gamma OS=Bos taurus OX=9913 GN=FAM120B PE=2 SV=1 CANONICAL=A6QNT4-1" }, "locus": { "chromosome": "9", "start_pos": 104011398, "end_pos": 103961339, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086653.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086653.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059855.3", "url": "https://www.ensembl.org/id/ENSBTAP00000059855.3" } ] } }, { "isoform_ac": "G5E564-1", "url": "https://www.uniprot.org/uniprotkb/A6QNT4/entry#G5E564-1", "sequence": { "sequence": "MGVRGLHGFVASSCPHVCTVVNFKELAERHRSQHPGGTPTIVVDAMCCLRYWYTPESWVCGGQWREYYSSLREFVRTFTAVGIKLIFFFDGMVEQSKRDEWVKRRLKNNREIAKIFHYIKSRREQPGRNMFFIPSGLAIFTRFALKALGQETLCSLQEADYEVASYGFQNNCLGILGEDTDYLIYDTCPYFSISELSLDSLDTVMLCREKLCQSLGLHLADLPLLACLLGNDVIPEGMFESFRYKCLTSYASVRESCDRKGNVILAVAEHISKVLRLHQGEKKLEEMLPLGPNKALFYKGVASYLLPGQKSPWFIQKPEDVVTLDKQVLSMSSDPESKQEFPVCMDSESKQKLPVGTDPEFNLEAPMCTNTEVKQEDPVNVGPEAKHQVTVVLDPEILKVARAQHVQAESYLVYSVMSSGEVECSNSLEDATDQALPSQAFVYRPVRQRVYSLLLGGGGGGSSTGPAVKEWFVYSGNPLRQPDLVRPLQMNIPGGTPSLRQLWLSQEPGIQAQRLDTLLACFDLSSSREELQAVERPFQALCCLLVYLFVQVDTLCLEDLHAFIAQALCLQGKPTMELADLQLDHIDPRAVQLATLLVRGLTTLVLVNGACGSPWEMADFMPWHLFDGKLFHQKYLQSEKGYTAEVLVEQNRSHVTRFHTLKSVVCKACGKESRPIVSRRHWRPHHAESPPLHVWRLPDSFPASSFRFSFYA", "length": 712, "header": "tr|G5E564-1|F120B_BOVIN Computationally mapped isoform of Constitutive coactivator of peroxisome proliferator-activated receptor gamma OS=Bos taurus OX=9913 GN=FAM120B PE=2 SV=3 CANONICAL=A6QNT4-1" }, "locus": { "chromosome": "9", "start_pos": 104002432, "end_pos": 103961339, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005065.8", "url": "https://www.ensembl.org/id/ENSBTAT00000005065.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005065.7", "url": "https://www.ensembl.org/id/ENSBTAP00000005065.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:524306", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524306", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A6QNT4", "url": "https://www.uniprot.org/uniprotkb/A6QNT4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A6QNT4", "url": "https://www.uniprot.org/uniprotkb/A6QNT4" } ], "pmid": "" }, { "name": "fat cell differentiation", "id": "GO:0045444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045444", "evidence": [ { "database": "UniProtKB", "id": "A6QNT4", "url": "https://www.uniprot.org/uniprotkb/A6QNT4" } ], "pmid": "" }, { "name": "peroxisome proliferator activated receptor signaling pathway", "id": "GO:0035357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035357", "evidence": [ { "database": "UniProtKB", "id": "A6QNT4", "url": "https://www.uniprot.org/uniprotkb/A6QNT4" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A6QNT4", "url": "https://www.uniprot.org/uniprotkb/A6QNT4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 651, "end_pos": 653, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QNT4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 700, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QNT4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QNT4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 651, "end_pos": 653 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QNL6-1", "uniprot_ac": "A6QNL6", "uniprot_id": "NKAI2_BOVIN", "mass": { "chemical_mass": 24444.0, "monoisotopic_mass": 24444.0 }, "refseq": {}, "gene_names": [ { "name": "NKAIN2", "type": "recommended", "evidence": [ { "id": "A6QNL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNL6" } ] } ], "protein_names": [ { "name": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2", "type": "recommended", "evidence": [ { "id": "A6QNL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNL6/entry#names_and_taxonomy" } ] }, { "name": "Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 2", "type": "synonym", "evidence": [ { "id": "A6QNL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNL6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QNL6", "url": "https://www.uniprot.org/uniprotkb/A6QNL6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NKAIN2", "url": "https://www.uniprot.org/uniprotkb/A6QNL6", "locus": { "chromosome": "9", "start_pos": 26363115, "end_pos": 27543403, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000052924", "url": "https://www.ensembl.org/id/ENSBTAG00000052924" } ] } } ], "crossref": [ { "id": "A6QNL6", "url": "https://alphafold.ebi.ac.uk/entry/A6QNL6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000052924", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000052924", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "787444", "url": "https://www.ncbi.nlm.nih.gov/gene/787444", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008516", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008516", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:787444", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787444", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MYIANSM", "url": "https://omabrowser.org/oma/group/MYIANSM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LS86", "url": "https://www.orthodb.org/?gene=A0A3Q1LS86", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A6QNL6", "url": "https://www.orthodb.org/?gene=A6QNL6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13084", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13084", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13084:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13084:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05640", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05640", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LS86", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LS86-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS86-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBL6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QNL6", "url": "https://www.uniprot.org/uniprotkb/A6QNL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QNL6-1", "url": "https://www.uniprot.org/uniprotkb/A6QNL6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGYCSGRCTLIFICGMQLVCVLERQIFDFLGYQWAPILANFVHIIIVILGLFGTIQYRPRYITGYAVWLVLWVTWNVFVICFYLEAGDLSKETDLILTFNISMHRSWWMENGPGCTVTSVTPAPDWAPEDHRYITVSGCFLEYQYIEVAHSSLQIVLALAGFIYACYVVKCITEEEDSFDFIGGFDSYGYQGPQKTSHLQLQPMYMQIPLDNN", "length": 213, "header": "sp|A6QNL6-1|NKAI2_BOVIN Isoform 1 of Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 OS=Bos taurus OX=9913 GN=NKAIN2 PE=2 SV=1 CANONICAL=A6QNL6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LS86-1", "url": "https://www.uniprot.org/uniprotkb/A6QNL6/entry#A0A3Q1LS86-1", "sequence": { "sequence": "MHRSWWMENGPGCTVTSVTPAPDWAPEDHRYITVSGCFLEYQYIEVAHSSLQIVLALAGFIYACYVVKCITEEEDSFDFIGGFDSYGYQGPQKTSHLQLQPMYMSK", "length": 106, "header": "tr|A0A3Q1LS86-1|NKAI2_BOVIN Computationally mapped isoform of Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 OS=Bos taurus OX=9913 GN=NKAIN2 PE=2 SV=1 CANONICAL=A6QNL6-1" }, "locus": { "chromosome": "9", "start_pos": 27543068, "end_pos": 26368645, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066433.1", "url": "https://www.ensembl.org/id/ENSBTAT00000066433.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060087.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060087.1" } ] } }, { "isoform_ac": "A0AAA9SBL6-1", "url": "https://www.uniprot.org/uniprotkb/A6QNL6/entry#A0AAA9SBL6-1", "sequence": { "sequence": "MGYCSGRCTLIFICGMQLVCVLERQIFDFLGYQWAPILANFVHIIIVILGLFGTIQYRPRYITGYAVWLVLWVTWNVFVICFYLEAGDLSKETDLILTFNISMHRSWWMENGPGCTVTSVTPAPDWAPEDHRYITVSGCFLEYQYIEVAHSSLQIVLALAGFIYACYVVKCITEEEDSFDFIGGFDSYGYQGPQKTSHLQLQPMYMSK", "length": 208, "header": "tr|A0AAA9SBL6-1|NKAI2_BOVIN Computationally mapped isoform of Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 OS=Bos taurus OX=9913 GN=NKAIN2 PE=2 SV=1 CANONICAL=A6QNL6-1" }, "locus": { "chromosome": "9", "start_pos": 27543068, "end_pos": 26364842, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089888.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089888.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081283.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081283.1" } ] } }, { "isoform_ac": "A6QNL6-1", "url": "https://www.uniprot.org/uniprotkb/A6QNL6/entry#A6QNL6-1", "sequence": { "sequence": "MGYCSGRCTLIFICGMQLVCVLERQIFDFLGYQWAPILANFVHIIIVILGLFGTIQYRPRYITGYAVWLVLWVTWNVFVICFYLEAGDLSKETDLILTFNISMHRSWWMENGPGCTVTSVTPAPDWAPEDHRYITVSGCFLEYQYIEVAHSSLQIVLALAGFIYACYVVKCITEEEDSFDFIGGFDSYGYQGPQKTSHLQLQPMYMQIPLDNN", "length": 213, "header": "sp|A6QNL6-1|NKAI2_BOVIN Isoform 1 of Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 OS=Bos taurus OX=9913 GN=NKAIN2 PE=2 SV=1 CANONICAL=A6QNL6-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 121, "start_aa": "Thr", "end_pos": 121, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr121", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:787444", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787444", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A6QNL6", "url": "https://www.uniprot.org/uniprotkb/A6QNL6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of sodium ion transport", "id": "GO:0002028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002028", "evidence": [ { "database": "UniProtKB", "id": "A6QNL6", "url": "https://www.uniprot.org/uniprotkb/A6QNL6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QNL6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 213, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QNL6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QNL6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 121 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QQ92-1", "uniprot_ac": "A6QQ92", "uniprot_id": "SERP3_BOVIN", "mass": { "chemical_mass": 43923.0, "monoisotopic_mass": 43923.0 }, "refseq": { "ac": "NP_001093829", "name": "serpin E3 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093829" }, "gene_names": [ { "name": "SERPINE3", "type": "recommended", "evidence": [ { "id": "A6QQ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ92" } ] }, { "name": "SERPINE3", "type": "synonym", "evidence": [ { "id": "NP_001093829", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093829" } ] } ], "protein_names": [ { "name": "Serpin E3", "type": "recommended", "evidence": [ { "id": "A6QQ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ92/entry#names_and_taxonomy" } ] }, { "name": "serpin E3 precursor", "type": "synonym", "evidence": [ { "id": "NP_001093829", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093829" } ] }, { "name": "serpin E3", "type": "synonym", "evidence": [ { "id": "NP_001093829", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093829" } ] }, { "name": "serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3", "type": "synonym", "evidence": [ { "id": "NP_001093829", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093829" } ] } ], "function": [ { "annotation": "Probable serine protease inhibitor.", "evidence": [ { "database": "UniProtKB", "id": "A6QQ92", "url": "https://www.uniprot.org/uniprotkb/A6QQ92#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QQ92", "url": "https://www.uniprot.org/uniprotkb/A6QQ92" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SERPINE3", "url": "https://www.uniprot.org/uniprotkb/A6QQ92", "locus": { "chromosome": "12", "start_pos": 20844748, "end_pos": 20784861, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005284", "url": "https://www.ensembl.org/id/ENSBTAG00000005284" } ] } } ], "crossref": [ { "id": "A6QQ92", "url": "https://alphafold.ebi.ac.uk/entry/A6QQ92", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005284", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005284", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19574", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19574", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513955", "url": "https://www.ncbi.nlm.nih.gov/gene/513955", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000215", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000215", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023796", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023796", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513955", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513955", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KGNCISY", "url": "https://omabrowser.org/oma/group/KGNCISY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LUK7", "url": "https://www.orthodb.org/?gene=A0A3Q1LUK7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A6QQ92", "url": "https://www.orthodb.org/?gene=A6QQ92", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461:SF129", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461:SF129", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00079", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00079", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001093829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093829", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUK7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUK7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUK7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYX9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA75-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQ92", "url": "https://www.uniprot.org/uniprotkb/A6QQ92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQ92-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ92-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQSLLLALLLLPVCSPGGASNLHEDLTLLRTDLALRLYRSVAAAGNQTNLVLSPAGAFIPLELLQFGARGNTGRQLAQALGYTVHDPKVREWLQTVYAVLPSTNPGAKLELACTLYVQTGTPLAPCFVEQVSRWANSSLELANFREPNSTAMLANGWGPRQTAGDEPVGSAWERGGGAESAQLVLVSTVSFQSAWRHQFSSDTQLLPFTCAQGLTLEVPMMYQMAEVNFGQFQDPAGHQVGVLELPYLGNVASLLLVLPRDRDTPLSHIEPHLTASLLHAWTASLKRARMEVFLPRFRIQNHFDLKNILYSWGVIDLFDPLRANLKGISGQDGFYVSEAIHKAKIEVSEEGTKASAATALLLLKRSRIPIFKADRPFIFFLREPNTAFVFSIGRVLNPLH", "length": 400, "header": "sp|A6QQ92-1|SERP3_BOVIN Isoform 1 of Serpin E3 OS=Bos taurus OX=9913 GN=SERPINE3 PE=2 SV=1 CANONICAL=A6QQ92-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LUK7-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ92/entry#A0A3Q1LUK7-1", "sequence": { "sequence": "MQSLLLALLLLPVCSPGGASNLHEDLTLLRTDLALRLYRSVAAAGNQTNLVLSPAGAFIPLELLQFGARGNTGRQLAQALGYTVHDPKVREWLQTVYAVLPSTNPGAKLELACTLYVQTGTPLAPCFVEQVSRWANSSLELANFREPNSTAMLANGWGPRQTAGDEPVGSAWERGGGAESAQLVLVSTVSFQSAWRHQFSSDTQLLPFTCAQGLTLEVPMMYQMAEVNFGQFQDPAGHQVGVLELPYLGNVASLLLVLPRDRDTPLSHIEPHLTASLLHAWTASLKRARMEVFLPRFRIQNHFDLKNILYSWGVIDLFDPLRANLKGISGQDGFYVSEAIHKAKIEVSEEGTKASAATALLLLKRSRIPIFKADRPFIFFLREPNTGILMVWYRQSLSTSEGQAEVL", "length": 407, "header": "tr|A0A3Q1LUK7-1|SERP3_BOVIN Computationally mapped isoform of Serpin E3 OS=Bos taurus OX=9913 GN=SERPINE3 PE=2 SV=2 CANONICAL=A6QQ92-1" }, "locus": { "chromosome": "12", "start_pos": 20814357, "end_pos": 20786464, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070909.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070909.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060825.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060825.2" } ] } }, { "isoform_ac": "A0AAA9RYX9-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ92/entry#A0AAA9RYX9-1", "sequence": { "sequence": "MQSLLLALLLLPVCSPGGASNLHEDLTLLRTDLALRLYRSVAAAGNQTNLVLSPAGAFIPLELLQFGARGNTGRQLAQALGYTVHDPKVREWLQTVYAVLPSTNPGAKLELACTLYVQTGTPLAPCFVEQVSRWANSSLELANFREPNSTAMLANGWGPRQTAGDEPVGSAWERGGGAESAQLVLVSTVSFQSAWRHQFSSDTQLLPFTCAQGLTLEVPMMYQMAEVNFGQFQDPAGHQVGVLELPYLGNVASLLLVLPRDRDTPLSHIEPHLTASLLHAWTASLKRARMEVFLPRFRIQNHFDLKNILYSWGVIDLFDPLRANLKGISGQDGFYVSEAIHKAKIEVSEEGTKASAATALLLLKRSRIPIFKADRPFIFFLREPNTGIREPSLRKDTGQKQLR", "length": 403, "header": "tr|A0AAA9RYX9-1|SERP3_BOVIN Computationally mapped isoform of Serpin E3 OS=Bos taurus OX=9913 GN=SERPINE3 PE=2 SV=1 CANONICAL=A6QQ92-1" }, "locus": { "chromosome": "12", "start_pos": 20814909, "end_pos": 20786464, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134088.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134088.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076349.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076349.1" } ] } }, { "isoform_ac": "A0AAA9TA75-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ92/entry#A0AAA9TA75-1", "sequence": { "sequence": "MQSLLLALLLLPVCSPGGASNLHEDLTLLRTDLALRLYRSVAAAGNQTNLVLSPAGAFIPLELLQFGARGNTGRQLAQALGYTVHDPKVREWLQTVYAVLPSTNPGAKLELACTLYVQTGTPLAPCFVEQVSRWANSSLELANFREPNSTAMLANGWGPRQTAGDEPVGSAWERGGGAESAQLVLVSTVSFQSAWRHQFSSDTQLLPFTCAQGLTLEVPMMYQMAEVNFGQFQDPAGHQVGVLELPYLGNVASLLLVLPRDRDTPLSHIEPHLTASLLHAWTASLKRARMEVFLPRFRIQNHFDLKNILYSWGVIDLFDPLRANLKGISGQDGFYVSEAIHKAKIEVSEEGTKASAATALLLLKRSRIPIFKADRPFIFFLREPNTAGYDGISTEHGQ", "length": 398, "header": "tr|A0AAA9TA75-1|SERP3_BOVIN Computationally mapped isoform of Serpin E3 OS=Bos taurus OX=9913 GN=SERPINE3 PE=2 SV=1 CANONICAL=A6QQ92-1" }, "locus": { "chromosome": "12", "start_pos": 20844648, "end_pos": 20786464, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118736.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118736.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092865.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092865.1" } ] } }, { "isoform_ac": "A6QQ92-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ92/entry#A6QQ92-1", "sequence": { "sequence": "MQSLLLALLLLPVCSPGGASNLHEDLTLLRTDLALRLYRSVAAAGNQTNLVLSPAGAFIPLELLQFGARGNTGRQLAQALGYTVHDPKVREWLQTVYAVLPSTNPGAKLELACTLYVQTGTPLAPCFVEQVSRWANSSLELANFREPNSTAMLANGWGPRQTAGDEPVGSAWERGGGAESAQLVLVSTVSFQSAWRHQFSSDTQLLPFTCAQGLTLEVPMMYQMAEVNFGQFQDPAGHQVGVLELPYLGNVASLLLVLPRDRDTPLSHIEPHLTASLLHAWTASLKRARMEVFLPRFRIQNHFDLKNILYSWGVIDLFDPLRANLKGISGQDGFYVSEAIHKAKIEVSEEGTKASAATALLLLKRSRIPIFKADRPFIFFLREPNTAFVFSIGRVLNPLH", "length": 400, "header": "sp|A6QQ92-1|SERP3_BOVIN Isoform 1 of Serpin E3 OS=Bos taurus OX=9913 GN=SERPINE3 PE=2 SV=1 CANONICAL=A6QQ92-1" }, "locus": { "chromosome": "12", "start_pos": 20816195, "end_pos": 20786464, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006956.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006956.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006956.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006956.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 46, "start_aa": "Asn", "end_pos": 46, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn46", "evidence": [ { "id": "A6QQ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ92#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:513955", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513955", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2QPV4-1", "protein_name": "Serpin E3", "gene_name": "Serpine3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLPLLLVTLFLVSSSFSAGGGSPLTEALWLLKTEFALHLYRSAAAQRNGTNFVISPASVSLSLEILQFGARGNTGWQLASALGYTVQDPRVREFLHSVYTTLHNSSQGIGMELACTLFIHTGASLSPCFVQQVSRWANSSLEPADFGEPNRTTMDVSKGTPRQSMGEGPGSPLWGQAGALSTQLSIMGTMTFQSTWQRRFSSMASQPLPFTCAQGLVLQVPAMHQVTEVSYGQFQDAAGHKVNVLELLYLGRVASLFLVLPQNKDTPLDLIEPHLTARVIHLWATRLKRTRMDVFLPRFRIQNQFDLKSILRSWGITDLFDPLKANLKGISGQDGFYVSEATHKAKMELSEEGTKSSAATAVLLLRRSRTPAFKADRPFIFLLREHSTGFVFSIGRLSNPLD", "length": 402 }, "evidence": [ { "id": "A6QQ92", "url": "https://omabrowser.org/oma/group/A6QQ92/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0X7M1-1", "protein_name": "Serpin family E member 3", "gene_name": "SERPINE3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLPIVFFALILTRCLAKGNCVSYDELKDLKIEFAINLYRHASEVENRTNLVISPASVAISLELLQFGAQGNTSMELQNALGYNIRDQSVQDMLHKVYEGAADSGQGAVVQLACSLFTHTGVQLSPRFAARVAHWANSSLQQADFTNPNQTAAQIQGWITGNLADRDVHGVPSEEAVSPLSRVAVVSTMYFKSTWLKKFSFTDTQILPFTTAESSTLKVPTMHHTAEVNYGQFQTATQDAFSVIELPYLGEKLSMFIVLPSHKRTPLSHIESHLSAKTIALWSSSLKRMKMDIFLPRFSIQSLFDLKTVFSALGIRDAFDPITANFKGISEQAGLYISEAIHKAKIEVTEDGTKASGATAMVLLKRSRTPIFKADRPFTFFLRQANTGSVLFIGRVTNPS", "length": 399 }, "evidence": [ { "id": "A6QQ92", "url": "https://omabrowser.org/oma/group/A6QQ92/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A8MV23-1", "protein_name": "Serpin E3", "gene_name": "SERPINE3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPPFLITLFLFHSCCLRANGHLREGMTLLKTEFALHLYQSVAACRNETNFVISPAGVSLPLEILQFGAEGSTGQQLADALGYTVHDKRVKDFLHAVYATLPTSSQGTEMELACSLFVQVGTPLSPCFVEHVSWWANSSLEPADLSEPNSTAIQTSEGASRETAGGGPSEGPGGWPWEQVSAAFAQLVLVSTMSFQGTWRKRFSSTDTQILPFTCAYGLVLQVPMMHQTTEVNYGQFQDTAGHQVGVLELPYLGSAVSLFLVLPRDKDTPLSHIEPHLTASTIHLWTTSLRRARMDVFLPRFRIQNQFNLKSILNSWGVTDLFDPLKANLKGISGQDGFYVSEAIHKAKIEVLEEGTKASGATALLLLKRSRIPIFKADRPFIYFLREPNTGITVFFDRIQIIYQCLSSNKGSFVHYPLKNKHSF", "length": 424 }, "evidence": [ { "id": "A6QQ92", "url": "https://omabrowser.org/oma/group/A6QQ92/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "B0UYL8-1", "protein_name": "Probable serpin E3", "gene_name": "serpine3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPQLSASSLFICLWLVDLCHVANSVLSSSFSDLHTQFGISLYQTLTETENKSNLIVSPASVSLCLGLLQLGARGNTLVQLEGTLGYDVNDVRVQNILSRPQGDLANSSEGLRLQLANALFIQTGVKLLPEFTQHALGWGNTSLLSVNFSNPNHTHSRLQQWAHYQSKADDHLQTREELHHSSGEEEEATRQDHLLYMALVSTLVFHGAWQKQFLFTETQNLPFTFSDGSTVKVPMMYQSSEVNIGHFRLPSEQEYTVLELPYLDHSLRLLVALPSDRKTPLSQLEKQITARAVGLWDTGLRRTKMDIFLPRFKMQSKINLKPVLQSLGVSDIFSPSAADFRGISDTDGIFVSEAFHEARIEVTEAGTKAASATAMVLLKRSRSAVFKADRPFLFILRQISTGSLLFIGRVVNPADMP", "length": 417 }, "evidence": [ { "id": "A6QQ92", "url": "https://omabrowser.org/oma/group/A6QQ92/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D4A9F7-1", "protein_name": "Serpin family E member 3", "gene_name": "Serpine3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLPLLQVTLFLLSSCFSAGGGSPLSEGLWLLKTEFALHLYQSAAAETNGTNFVISPASVSLSLEILQFAARGNTGWQLAEALGYTVQDPRVREFLHTVYITLHNSSQGIGMELACTLFMQTGTSLSPCFVEQVSRWANSSLELADFSEPNTTTMEASKGTTRPSTGEGPGSPLWGRAGALSTQLSIVSTMTFQSSWQQRFSSVALQPLPFTCAHGLVLQVPAMHQVAEVSYGQFQDAAGHKVDVLELLYLGRVASLLLVLPQDKGTPLDHIEPHLTARVIHLWTTRLKRARMDVFLPRFRIQNQFDLKSILRSWGITDLFDPLKANLKGISGRDGFYVSEVTHKAKMELSEEGTKSCAATAVLLLRRSRTPAFKADRPFIFLLREHNTGFVFSIGRVSNPLD", "length": 402 }, "evidence": [ { "id": "A6QQ92", "url": "https://omabrowser.org/oma/group/A6QQ92/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9Q6A2-1", "protein_name": "Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3", "gene_name": "Serpine3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPLLQVTFFLLSSCFSAGGGSPLSEGLWLLKTEFALHLYRSAAAERNGTNFVISPASVSLSLEILQFGARGNTGWQLAGALGYTVQDPRVKEFLHAVYTTRHNSSQGVGMELACTLFMQTGTSLSPCFVEQVSRWANSSLEAADFSEPNSTTTEASKVTSRQSTGEGPDSPLWGRADALSTQLSIMSTMTFQSTWQKRFSVVLQPLPFTHAHGLVLQVPAMHQVAEVSYGQFQDAAGHEIAVLELLYLGRVASLLLVLPQDKGTPLDHIEPHLTARVLHLWTTRLKRARMDVFLPRFKIQNQFDVKSILRSWGITDLFDPLKANLKGISGQDGFYVSQLTHKAKMELSEEGTRSSAATAVLLLRRSRTSAFKADRPFIFLLREHSTGFVFSIGRVSNPLD", "length": 401 }, "evidence": [ { "id": "A6QQ92", "url": "https://omabrowser.org/oma/group/A6QQ92/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "A6QQ92", "url": "https://www.uniprot.org/uniprotkb/A6QQ92" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A6QQ92", "url": "https://www.uniprot.org/uniprotkb/A6QQ92" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 136, "end_pos": 138, "annotation": "n_glycosylation_sequon" }, { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QQ92-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 400, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QQ92-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QQ92" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 46 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 136, "end_pos": 138 }, { "start_pos": 148, "end_pos": 150 }, { "start_pos": 46, "end_pos": 48 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QL70-1", "uniprot_ac": "A6QL70", "uniprot_id": "PED1B_BOVIN", "mass": { "chemical_mass": 50742.0, "monoisotopic_mass": 50742.0 }, "refseq": { "ac": "NP_001094677", "name": "PC-esterase domain-containing protein 1B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094677" }, "gene_names": [ { "name": "PCED1B", "type": "recommended", "evidence": [ { "id": "A6QL70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QL70" } ] }, { "name": "FAM113B", "type": "synonym", "evidence": [ { "id": "NP_001094677", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094677" }, { "id": "A6QL70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QL70" } ] }, { "name": "PCED1B", "type": "synonym", "evidence": [ { "id": "NP_001094677", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094677" } ] } ], "protein_names": [ { "name": "PC-esterase domain-containing protein 1B", "type": "recommended", "evidence": [ { "id": "A6QL70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QL70/entry#names_and_taxonomy" } ] }, { "name": "PC-esterase domain-containing protein 1B", "type": "synonym", "evidence": [ { "id": "NP_001094677", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094677" } ] }, { "name": "Protein FAM113B", "type": "synonym", "evidence": [ { "id": "NP_001094677", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094677" }, { "id": "A6QL70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QL70/entry#names_and_taxonomy" } ] }, { "name": "family with sequence similarity 113, member B", "type": "synonym", "evidence": [ { "id": "NP_001094677", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094677" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QL70", "url": "https://www.uniprot.org/uniprotkb/A6QL70" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCED1B", "url": "https://www.uniprot.org/uniprotkb/A6QL70", "locus": { "chromosome": "5", "start_pos": 33019350, "end_pos": 33172962, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011838", "url": "https://www.ensembl.org/id/ENSBTAG00000011838" } ] } } ], "crossref": [ { "id": "A6QL70", "url": "https://alphafold.ebi.ac.uk/entry/A6QL70", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011838", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011838", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540367", "url": "https://www.ncbi.nlm.nih.gov/gene/540367", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR036514", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036514", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540367", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540367", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YFHSDVP", "url": "https://omabrowser.org/oma/group/YFHSDVP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MC51", "url": "https://www.orthodb.org/?gene=A0A3Q1MC51", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A6QL70", "url": "https://www.orthodb.org/?gene=A6QL70", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14469", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14469", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14469:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14469:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001094677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094677", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC51", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC51-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QL70", "url": "https://www.uniprot.org/uniprotkb/A6QL70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QL70-1", "url": "https://www.uniprot.org/uniprotkb/A6QL70-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVHLLASEVRQLLHNKFVVILGDSVQRAVYKDLVLLLQKDCLLTLSQLKAKGEHTFEQDELVHGGQQGHMHNGTHYREVRQFCSGQHLVRFYFLTRVYSDYLEDVLEELQSGEHHPDLVIMNSCLWDITRYGKDFWPSYRRNLERLFGRLRQMLSESCLLVWNTAMPVGDKITSRFVPPEVQFTSSSVKISVIEANFYSSAEAQKHGFDVLDLHFHFRRHTGKYLQTDGVHWNQCAHRHLSQLLLAHVADAWGVELPRRDPVDKWIPDGPGRRRPGRRLERQPLVCGDQPACPLPRPLPLPGRQPLLPTPPCPPLFPLLSPQRHPIPLHQVMPPFPFCPQETCFSSDHPFQSDQFSLNYLHSDVPPSIQTEFAVQGDFQYGPQPPMPRFPPPCYQQRVPEVHRGFPRYHPPDPYMPWRRRPKTSKRRASAYKEPRPQ", "length": 437, "header": "sp|A6QL70-1|PED1B_BOVIN Isoform 1 of PC-esterase domain-containing protein 1B OS=Bos taurus OX=9913 GN=PCED1B PE=2 SV=1 CANONICAL=A6QL70-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MC51-1", "url": "https://www.uniprot.org/uniprotkb/A6QL70/entry#A0A3Q1MC51-1", "sequence": { "sequence": "MTIRNSFLPEPPSADPLSERKELGGADVMVHLLASEVRQLLHNKFVVILGDSVQRAVYKDLVLLLQKDCLLTLSQLKAKGEHTFEQDELVHGGQQGHMHNGTHYREVRQFCSGQHLVRFYFLTRVYSDYLEDVLEELQSGEHHPDLVIMNSCLWDITRYGKDFWPSYRRNLERLFGRLRQMLSESCLLVWNTAMPVGDKITSRFVPPEVQFTSSSVKISVIEANFYSSAEAQKHGFDVLDLHFHFRRHTGKYLQTDGVHWNQCAHRHLSQLLLAHVADAWGVELPRRDPVDKWIPDGPGRRRPGRRLERQPLVCGDQPACPLPRPLPLPGRQPLLPTPPCPPLFPLLSPQRHPIPLHQVMPPFPFCPQETCFSSDHPFQSDQFSLNYLHSDVPPSIQTEFAVQGDFQYGPQPPMPRFPPPCYQQRVPEVHRGFPRYHPPDPYMPWRRRPKTSKRRASAYKEPRPQ", "length": 465, "header": "tr|A0A3Q1MC51-1|PED1B_BOVIN Computationally mapped isoform of PC-esterase domain-containing protein 1B OS=Bos taurus OX=9913 GN=PCED1B PE=2 SV=1 CANONICAL=A6QL70-1" }, "locus": { "chromosome": "5", "start_pos": 33021345, "end_pos": 33020035, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066673.1", "url": "https://www.ensembl.org/id/ENSBTAT00000066673.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068375.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068375.1" } ] } }, { "isoform_ac": "A6QL70-1", "url": "https://www.uniprot.org/uniprotkb/A6QL70/entry#A6QL70-1", "sequence": { "sequence": "MVHLLASEVRQLLHNKFVVILGDSVQRAVYKDLVLLLQKDCLLTLSQLKAKGEHTFEQDELVHGGQQGHMHNGTHYREVRQFCSGQHLVRFYFLTRVYSDYLEDVLEELQSGEHHPDLVIMNSCLWDITRYGKDFWPSYRRNLERLFGRLRQMLSESCLLVWNTAMPVGDKITSRFVPPEVQFTSSSVKISVIEANFYSSAEAQKHGFDVLDLHFHFRRHTGKYLQTDGVHWNQCAHRHLSQLLLAHVADAWGVELPRRDPVDKWIPDGPGRRRPGRRLERQPLVCGDQPACPLPRPLPLPGRQPLLPTPPCPPLFPLLSPQRHPIPLHQVMPPFPFCPQETCFSSDHPFQSDQFSLNYLHSDVPPSIQTEFAVQGDFQYGPQPPMPRFPPPCYQQRVPEVHRGFPRYHPPDPYMPWRRRPKTSKRRASAYKEPRPQ", "length": 437, "header": "sp|A6QL70-1|PED1B_BOVIN Isoform 1 of PC-esterase domain-containing protein 1B OS=Bos taurus OX=9913 GN=PCED1B PE=2 SV=1 CANONICAL=A6QL70-1" }, "locus": { "chromosome": "5", "start_pos": 33021345, "end_pos": 33020035, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099838.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099838.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092718.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092718.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 309, "start_aa": "Thr", "end_pos": 309, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr309", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:540367", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540367", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q2M1K5-1", "protein_name": "PC-esterase domain-containing protein 1B", "gene_name": "Pced1b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVRLLASEVQQLLHNKFVVVLGDSVHRAVYKDLVLLLQKDCLLTNKQLRTKGELSFEKDQLMMGGELDTLHNRTDYREVREFCSDHHLVRFYFLTRVYSEYMESVLKELQSGNHAPDVIIMNSCLWDVSRYGRNSLSSYRQNLENLFGRMDEVLPKSCLLVWNTAMPLGDKIKAAFLPQKCKGQYPRISVATLKKKVTQANFYSHAEATKHYFDVLDLNFHFRQARKHLQGDGVHWNEHAHRKLSYLLLAHMADAWGVELPHRDPWEPGFEAWESSGQVEERQPQDNIGPQFAQSPPYPFPRPPPLLPSPGLPIRPPPLLGCPLPPPQPMPPLPLYPQVSYFSSDPVFQSDEFYIHSDSPSSNHTGYAFEGDFSFYPQPPMPNFRPPCHQRQAPVVHRGFPRHFPRGPYMPWRERPRRPQKHAPACLESRPQ", "length": 432 }, "evidence": [ { "id": "A6QL70", "url": "https://omabrowser.org/oma/group/A6QL70/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BGX1-1", "protein_name": "PC-esterase domain-containing protein 1B", "gene_name": "Pced1b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVRLLASEVQQLLHNKFVVVLGDSVHRAVYKDLVLLLQKDCLLTNKQLRTKGELSFEKDQLKMGGELDTLHNRTDYREVREFCSDHHLVRFYFLTRVYSEYMESVLEELQSGNHAPDVIIMNSCLWDVSRYGRNSLSSYKQNLENLFGRMDQVLPKSCLLVWNTAMPLGDKIKAAFLPQKCKGQYPRISVATLKRKVTQANLYSHAEATKHYFDVLDLNFHFRQARKHLQGDGVHWNEHAHRKLSYLLLAHMADAWGVELPQRDSWEPDFEAWESSGQVEERQPQDNLGPQVFAPSPHCPFRPPPLLPSPGLPIRPPPLLGCPLPQPQQMPPFPLYPQVSYFSSDPVFQSDEFYIHSDSPPPTHTGYAFEGDFSFYPQPPVPNFRPPCHQRQAPVVHRGFPRHFARGPYSNPWRDRPRRPPKHSPAGLESRPQ", "length": 433 }, "evidence": [ { "id": "A6QL70", "url": "https://omabrowser.org/oma/group/A6QL70/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96HM7-1", "protein_name": "PC-esterase domain-containing protein 1B", "gene_name": "PCED1B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MILLRASEVRQLLHNKFVVILGDSVHRAVYKDLVLLLQKDRLLTPGQLRARGELNFEQDELVDGGQRGHMHNGLNYREVREFRSDHHLVRFYFLTRVYSDYLQTILKELQSGEHAPDLVIMNSCLWDISRYGPNSWRSYLENLENLFQCLGQVLPESCLLVWNTAMPVGEEVTGGFLPPKLRRQKATFLKNEVVKANFHSATEARKHNFDVLDLHFHFRHARENLHWDGVHWNGRVHRCLSQLLLAHVADAWGVELPHRHPVGEWIKKKKPGPRVEGPPQANRNHPALPLSPPLPSPTYRPLLGFPPQRLPLLPLLSPQPPPPILHHQGMPRFPQGPPDACFSSDHTFQSDQFYCHSDVPSSAHAGFFVEDNFMVGPQLPMPFFPTPRYQRPAPVVHRGFGRYRPRGPYTPWGQRPRPSKRRAPANPEPRPQ", "length": 432 }, "evidence": [ { "id": "A6QL70", "url": "https://omabrowser.org/oma/group/A6QL70/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QL70-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 437, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QL70-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QL70" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 309 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 72, "end_pos": 74 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QQY2-1", "uniprot_ac": "A6QQY2", "uniprot_id": "KLH13_BOVIN", "mass": { "chemical_mass": 73902.0, "monoisotopic_mass": 73902.0 }, "refseq": { "ac": "NP_001095981", "name": "kelch-like protein 13", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095981" }, "gene_names": [ { "name": "KLHL13", "type": "recommended", "evidence": [ { "id": "A6QQY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQY2" } ] }, { "name": "KLHL13", "type": "synonym", "evidence": [ { "id": "NP_001095981", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095981" } ] } ], "protein_names": [ { "name": "Kelch-like protein 13", "type": "recommended", "evidence": [ { "id": "A6QQY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQY2/entry#names_and_taxonomy" } ] }, { "name": "kelch-like 13", "type": "synonym", "evidence": [ { "id": "NP_001095981", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095981" } ] }, { "name": "kelch-like protein 13", "type": "synonym", "evidence": [ { "id": "NP_001095981", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095981" } ] } ], "function": [ { "annotation": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A6QQY2", "url": "https://www.uniprot.org/uniprotkb/A6QQY2#function" }, { "database": "UniProtKB", "id": "A0A3Q1MPC8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPC8#function" }, { "database": "UniProtKB", "id": "ARBA00056604", "url": "https://www.uniprot.org/uniprotkb/ARBA00056604#function" }, { "database": "UniProtKB", "id": "A0A3Q1N4U1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4U1#function" }, { "database": "UniProtKB", "id": "A0AAA9SEQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEQ5#function" }, { "database": "UniProtKB", "id": "A0AAA9SUW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW5#function" }, { "database": "UniProtKB", "id": "A0AAA9T0I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0I8#function" }, { "database": "UniProtKB", "id": "A0AAA9TNF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNF0#function" }, { "database": "UniProtKB", "id": "A0AAF6ZW47", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZW47#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QQY2", "url": "https://www.uniprot.org/uniprotkb/A6QQY2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KLHL13", "url": "https://www.uniprot.org/uniprotkb/A6QQY2", "locus": { "chromosome": "X", "start_pos": 2100820, "end_pos": 2376650, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000501", "url": "https://www.ensembl.org/id/ENSBTAG00000000501" } ] } } ], "crossref": [ { "id": "A6QQY2", "url": "https://alphafold.ebi.ac.uk/entry/A6QQY2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000501", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000501", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18239", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18239", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18449", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18449", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "528138", "url": "https://www.ncbi.nlm.nih.gov/gene/528138", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528138", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528138", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "XGITHDT", "url": "https://omabrowser.org/oma/group/XGITHDT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MPC8", "url": "https://www.orthodb.org/?gene=A0A3Q1MPC8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N4U1", "url": "https://www.orthodb.org/?gene=A0A3Q1N4U1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A6QQY2", "url": "https://www.orthodb.org/?gene=A6QQY2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45632", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45632", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45632:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45632:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24681", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24681", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001095981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095981", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPC8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPC8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPC8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N4U1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4U1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N4U1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4U1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUW5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0I8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0I8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0I8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNF0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZW47", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZW47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZW47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZW47-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQY2", "url": "https://www.uniprot.org/uniprotkb/A6QQY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQY2-1", "url": "https://www.uniprot.org/uniprotkb/A6QQY2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGSSEMGLSSHLQSSKAGTTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP", "length": 655, "header": "sp|A6QQY2-1|KLH13_BOVIN Isoform 1 of Kelch-like protein 13 OS=Bos taurus OX=9913 GN=KLHL13 PE=2 SV=1 CANONICAL=A6QQY2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MPC8-1", "url": "https://www.uniprot.org/uniprotkb/A6QQY2/entry#A0A3Q1MPC8-1", "sequence": { "sequence": "MMRVQTLREKWAYWRRRQLSLKQADFKDIFKKSTSGSLVEEEDQHMKLSLGSSEMGLSSHLQSSKAGTTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP", "length": 658, "header": "tr|A0A3Q1MPC8-1|KLH13_BOVIN Computationally mapped isoform of Kelch-like protein 13 OS=Bos taurus OX=9913 GN=KLHL13 PE=2 SV=2 CANONICAL=A6QQY2-1" }, "locus": { "chromosome": "X", "start_pos": 2176002, "end_pos": 2101926, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083269.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083269.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071504.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071504.2" } ] } }, { "isoform_ac": "A0A3Q1N4U1-1", "url": "https://www.uniprot.org/uniprotkb/A6QQY2/entry#A0A3Q1N4U1-1", "sequence": { "sequence": "MSDSLQPHGLYSPWNSPGQNTGVGSLSRLQGIFPSQRSNPGLPHCRRILYQVIIQLLEVMDHLHRGESIAAILRNRSLVEEEDQHMKLSLGSSEMGLSSHLQSSKAGTTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP", "length": 698, "header": "tr|A0A3Q1N4U1-1|KLH13_BOVIN Computationally mapped isoform of Kelch-like protein 13 OS=Bos taurus OX=9913 GN=KLHL13 PE=2 SV=2 CANONICAL=A6QQY2-1" }, "locus": { "chromosome": "X", "start_pos": 2223245, "end_pos": 2101926, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071219.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071219.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064892.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064892.2" } ] } }, { "isoform_ac": "A0AAA9SEQ5-1", "url": "https://www.uniprot.org/uniprotkb/A6QQY2/entry#A0AAA9SEQ5-1", "sequence": { "sequence": "MLRFISHLYCCSSKEECSEDDKCILSRSLVEEEDQHMKLSLGSSEMGLSSHLQSSKAGTTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP", "length": 649, "header": "tr|A0AAA9SEQ5-1|KLH13_BOVIN Computationally mapped isoform of Kelch-like protein 13 OS=Bos taurus OX=9913 GN=KLHL13 PE=2 SV=1 CANONICAL=A6QQY2-1" }, "locus": { "chromosome": "X", "start_pos": 2163842, "end_pos": 2101926, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125282.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125282.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082102.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082102.1" } ] } }, { "isoform_ac": "A0AAA9SUW5-1", "url": "https://www.uniprot.org/uniprotkb/A6QQY2/entry#A0AAA9SUW5-1", "sequence": { "sequence": "MDHLHRGESIAAILRNRSLVEEEDQHMKLSLGSSEMGLSSHLQSSKAGTTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP", "length": 639, "header": "tr|A0AAA9SUW5-1|KLH13_BOVIN Computationally mapped isoform of Kelch-like protein 13 OS=Bos taurus OX=9913 GN=KLHL13 PE=2 SV=1 CANONICAL=A6QQY2-1" }, "locus": { "chromosome": "X", "start_pos": 2216974, "end_pos": 2101926, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122251.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122251.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087960.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087960.1" } ] } }, { "isoform_ac": "A0AAA9T0I8-1", "url": "https://www.uniprot.org/uniprotkb/A6QQY2/entry#A0AAA9T0I8-1", "sequence": { "sequence": "MHWRRKWQPTPVFLPGESQGRGSLVIIQLLEVMDHLHRGESIAAILRNRRRRQLSLKQADFKDIFKKSTSGSLVEEEDQHMKLSLGSSEMGLSSHLQSSKAGTTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP", "length": 693, "header": "tr|A0AAA9T0I8-1|KLH13_BOVIN Computationally mapped isoform of Kelch-like protein 13 OS=Bos taurus OX=9913 GN=KLHL13 PE=2 SV=1 CANONICAL=A6QQY2-1" }, "locus": { "chromosome": "X", "start_pos": 2276490, "end_pos": 2101926, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096980.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096980.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089160.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089160.1" } ] } }, { "isoform_ac": "A0AAA9TNF0-1", "url": "https://www.uniprot.org/uniprotkb/A6QQY2/entry#A0AAA9TNF0-1", "sequence": { "sequence": "MHWRRKWQPTPVFLPGESQGRGSLVIIQLLEVMDHLHRGESIAAILRNRSLVEEEDQHMKLSLGSSEMGLSSHLQSSKAGTTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP", "length": 671, "header": "tr|A0AAA9TNF0-1|KLH13_BOVIN Computationally mapped isoform of Kelch-like protein 13 OS=Bos taurus OX=9913 GN=KLHL13 PE=2 SV=1 CANONICAL=A6QQY2-1" }, "locus": { "chromosome": "X", "start_pos": 2276490, "end_pos": 2101926, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104587.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104587.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097875.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097875.1" } ] } }, { "isoform_ac": "A0AAF6ZW47-1", "url": "https://www.uniprot.org/uniprotkb/A6QQY2/entry#A0AAF6ZW47-1", "sequence": { "sequence": "MAGEFFFEESLFLDFLFKLSLVEEEDQHMKLSLGSSEMGLSSHLQSSKAGTTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP", "length": 641, "header": "tr|A0AAF6ZW47-1|KLH13_BOVIN Computationally mapped isoform of Kelch-like protein 13 OS=Bos taurus OX=9913 GN=KLHL13 PE=2 SV=1 CANONICAL=A6QQY2-1" }, "locus": { "chromosome": "X", "start_pos": 2146785, "end_pos": 2101926, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083192.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083192.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059010.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059010.2" } ] } }, { "isoform_ac": "A6QQY2-1", "url": "https://www.uniprot.org/uniprotkb/A6QQY2/entry#A6QQY2-1", "sequence": { "sequence": "MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGSSEMGLSSHLQSSKAGTTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP", "length": 655, "header": "sp|A6QQY2-1|KLH13_BOVIN Isoform 1 of Kelch-like protein 13 OS=Bos taurus OX=9913 GN=KLHL13 PE=2 SV=1 CANONICAL=A6QQY2-1" }, "locus": { "chromosome": "X", "start_pos": 2163227, "end_pos": 2101926, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000639.5", "url": "https://www.ensembl.org/id/ENSBTAT00000000639.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000639.4", "url": "https://www.ensembl.org/id/ENSBTAP00000000639.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:528138", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528138", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4IP02-1", "protein_name": "Kelch-like protein 13 isoform X4", "gene_name": "klhl13", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPLKWKSGSPVSWKFPVPVLKTSRSSPLSPAYISLVEDDDAQMMKVSLGCSEMGLSSHLQASKTGNTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVAGDGDEAFPVHRAMMASSSDYFKAMFTGGMKEQDLMCIKLHGVNRIGLKKIIDFIYTAKLSLNMENLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLTEVDKYVNNFILKNFPSLLGTGEFVKLPFERLAFVLSSNSLKHCSELDLFKSACRWLRYEEGRMEYAAKLMRNIRFPLMSPTELINHVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSERTAIRSDNTHLVTLGGVLRQQLVVSKELRLFDEKAHEWKALAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRYDPRYNKWIQVACLNEKRTFFHLSALKGYLYAVGGRNAAGELATVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGYMYISGGITHDTFQKELMCFDPDADKWTQKAPMTTVRGLHCMCTVGDRLYVIGGNHFRGTSDYDDVLSCEYYSPALDLWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEDLSLAGSPSRESPLSAP", "length": 658 }, "evidence": [ { "id": "A6QQY2", "url": "https://omabrowser.org/oma/group/A6QQY2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A287ACD9-1", "protein_name": "Kelch like family member 13", "gene_name": "KLHL13", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDHLHRGESVAAILRNRSLVEEEDQHMKLSLGSSEMGLSSHLQSSKAGTTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP", "length": 639 }, "evidence": [ { "id": "A6QQY2", "url": "https://omabrowser.org/oma/group/A6QQY2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6A140-1", "protein_name": "Kelch-like family member 13", "gene_name": "Klhl13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDILHRGELVAAILRNRSLVEEEDQHLKLCLGSEMGLSSHLQSCKAGSTRIFTSNSHSSVVLQGFDQLRLDGLLCDVTLMPGDTDDAYPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELELFKATCRWLRLEEPRMDVAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPFMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKTHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWIQVASLNEKRTFFHLSALKGFLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMNEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGDRLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIASMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKNEWHKVFDLPESLGGIRACTLTVYPPEENTPSPSRESPLSGP", "length": 638 }, "evidence": [ { "id": "A6QQY2", "url": "https://omabrowser.org/oma/group/A6QQY2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80TF4-1", "protein_name": "Kelch-like protein 13", "gene_name": "Klhl13", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHLKLCLGSEMGLSSHLQSCKAGSTRIFTSNSHSSVVLQGFDQLRLDGLLCDVTLMPGDTDDAYPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLEEPRMDVAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPFMQPVMQSDRTAIRSDTTRLVTLGGVLRQQLVVSKELRMYDEKTHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWIQVASLNEKRTFFHLSALKGFLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMNEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWTQKAPMTTVRGLHCMCTVGDRLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIASMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKNEWHKVFDLPESLGGIRACTLTVYPPEEATPSPSRESPLSGP", "length": 654 }, "evidence": [ { "id": "A6QQY2", "url": "https://omabrowser.org/oma/group/A6QQY2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P2N7-1", "protein_name": "Kelch-like protein 13", "gene_name": "KLHL13", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP", "length": 655 }, "evidence": [ { "id": "A6QQY2", "url": "https://omabrowser.org/oma/group/A6QQY2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A6QQY2", "url": "https://www.uniprot.org/uniprotkb/A6QQY2" } ], "pmid": "" }, { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "A6QQY2", "url": "https://www.uniprot.org/uniprotkb/A6QQY2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A6QQY2", "url": "https://www.uniprot.org/uniprotkb/A6QQY2" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "A6QQY2", "url": "https://www.uniprot.org/uniprotkb/A6QQY2" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "A6QQY2", "url": "https://www.uniprot.org/uniprotkb/A6QQY2" } ], "pmid": "" }, { "name": "regulation of cytokinesis", "id": "GO:0032465", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032465", "evidence": [ { "database": "UniProtKB", "id": "A6QQY2", "url": "https://www.uniprot.org/uniprotkb/A6QQY2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "A6QQY2", "url": "https://www.uniprot.org/uniprotkb/A6QQY2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QQY2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 655, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QQY2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QQY2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A6QQY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQY2" }, { "id": "PRU00037", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00037" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000255", "start_pos": 92, "end_pos": 161, "start_aa": "Cys", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 207, "end_pos": 209 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QQ59-1", "uniprot_ac": "A6QQ59", "uniprot_id": "KTAP2_BOVIN", "mass": { "chemical_mass": 14679.0, "monoisotopic_mass": 14679.0 }, "refseq": { "ac": "NP_001094679", "name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094679" }, "gene_names": [ { "name": "KRTCAP2", "type": "recommended", "evidence": [ { "id": "A6QQ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ59" } ] }, { "name": "KCP-2", "type": "synonym", "evidence": [ { "id": "NP_001094679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094679" } ] }, { "name": "KRTCAP2", "type": "synonym", "evidence": [ { "id": "NP_001094679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094679" } ] } ], "protein_names": [ { "name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2", "type": "recommended", "evidence": [ { "id": "A6QQ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ59/entry#names_and_taxonomy" } ] }, { "name": "KCP-2", "type": "synonym", "evidence": [ { "id": "A6QQ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ59/entry#names_and_taxonomy" } ] }, { "name": "Keratinocyte-associated protein 2", "type": "synonym", "evidence": [ { "id": "NP_001094679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094679" }, { "id": "A6QQ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ59/entry#names_and_taxonomy" } ] }, { "name": "Oligosaccharyl transferase subunit KCP2", "type": "synonym", "evidence": [ { "id": "A6QQ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ59/entry#names_and_taxonomy" } ] }, { "name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2", "type": "synonym", "evidence": [ { "id": "NP_001094679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094679" } ] }, { "name": "oligosaccharyl transferase subunit KCP2", "type": "synonym", "evidence": [ { "id": "NP_001094679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094679" } ] } ], "function": [ { "annotation": "Subunit of STT3A-containing oligosaccharyl transferase (OST-A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF7A5N0", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5N0#function" }, { "database": "UniProtKB", "id": "ARBA00053818", "url": "https://www.uniprot.org/uniprotkb/ARBA00053818#function" }, { "database": "UniProtKB", "id": "A6QQ59", "url": "https://www.uniprot.org/uniprotkb/A6QQ59#function" }, { "database": "UniProtKB", "id": "Q8N6L1", "url": "https://www.uniprot.org/uniprotkb/Q8N6L1#function" }, { "database": "UniProtKB", "id": "A0A452DJ51", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ51#function" }, { "database": "UniProtKB", "id": "A0AAA9TLA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLA4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QQ59", "url": "https://www.uniprot.org/uniprotkb/A6QQ59" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRTCAP2", "url": "https://www.uniprot.org/uniprotkb/A6QQ59", "locus": { "chromosome": "3", "start_pos": 15446566, "end_pos": 15442354, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010617", "url": "https://www.ensembl.org/id/ENSBTAG00000010617" } ] } } ], "crossref": [ { "id": "A6QQ59", "url": "https://alphafold.ebi.ac.uk/entry/A6QQ59", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010617", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010617", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540389", "url": "https://www.ncbi.nlm.nih.gov/gene/540389", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018614", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018614", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540389", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540389", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ITIYYMN", "url": "https://omabrowser.org/oma/group/ITIYYMN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJ51", "url": "https://www.orthodb.org/?gene=A0A452DJ51", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A6QQ59", "url": "https://www.orthodb.org/?gene=A6QQ59", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32001:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32001:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09775", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09775", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001094679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094679", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DJ51", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ51-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLA4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A5N0", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5N0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A5N0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A5N0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQ59", "url": "https://www.uniprot.org/uniprotkb/A6QQ59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQ59-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ59-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVVGTGTSLALSSLLSLLLFAGMQMYSRQLASTEWLTIQGGLLGSGLFVFSLTAFNNLENLVFGKGFQAKIFPEILLCLLLALFASGLIHRVCVTTCFIFSMVGLYYINKISSTLYQATAPVLTPAKVTGKGKKRN", "length": 136, "header": "sp|A6QQ59-1|KTAP2_BOVIN Isoform 1 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2 OS=Bos taurus OX=9913 GN=KRTCAP2 PE=2 SV=1 CANONICAL=A6QQ59-1" }, "isoforms": [ { "isoform_ac": "A0A452DJ51-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ59/entry#A0A452DJ51-1", "sequence": { "sequence": "MMVVGTGTSLALSSLLSLLLFAGMQMYSRQLASTEWLTIQGGLLGSGLFVFSLTAFNNLENLVFGKGFQAKIFPEILLCLLLALFASGLIHRVCVTTCFIFSMVGLYYINKISSTLYQATAPVLTPAKVTGKGKKRN", "length": 137, "header": "tr|A0A452DJ51-1|KTAP2_BOVIN Computationally mapped isoform of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2 OS=Bos taurus OX=9913 GN=KRTCAP2 PE=2 SV=1 CANONICAL=A6QQ59-1" }, "locus": {} }, { "isoform_ac": "A0AAA9TLA4-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ59/entry#A0AAA9TLA4-1", "sequence": { "sequence": "MRTANRPPVRLSSWAEARIGPKVVGTGTSLALSSLLSLLLFAGMQMYSRQLASTEWLTIQGGLLGSGLFVFSLTAFNNLENLVFGKGFQAKIFPEILLCLLLALFASGLIHRVCVTTCFIFSMVGLYYINKISSTLYQATAPVLTPAKVTGKGKKRN", "length": 157, "header": "tr|A0AAA9TLA4-1|KTAP2_BOVIN Computationally mapped isoform of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2 OS=Bos taurus OX=9913 GN=KRTCAP2 PE=2 SV=1 CANONICAL=A6QQ59-1" }, "locus": { "chromosome": "3", "start_pos": 15446526, "end_pos": 15443967, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113368.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113368.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097978.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097978.1" } ] } }, { "isoform_ac": "A0AAF7A5N0-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ59/entry#A0AAF7A5N0-1", "sequence": { "sequence": "MVVGTGTSLALSSLLSLLLFAGMQMYSRQLASTEWLTIQGGLLGSGLFVFSLTEAPGWQMPINATTVSSPCSFIFSMVGLYYINKISSTLYQATAPVLTPAKVTGKGKKRN", "length": 111, "header": "tr|A0AAF7A5N0-1|KTAP2_BOVIN Computationally mapped isoform of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2 OS=Bos taurus OX=9913 GN=KRTCAP2 PE=2 SV=1 CANONICAL=A6QQ59-1" }, "locus": { "chromosome": "3", "start_pos": 15446526, "end_pos": 15444044, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086011.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086011.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063660.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063660.2" } ] } }, { "isoform_ac": "A6QQ59-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ59/entry#A6QQ59-1", "sequence": { "sequence": "MVVGTGTSLALSSLLSLLLFAGMQMYSRQLASTEWLTIQGGLLGSGLFVFSLTAFNNLENLVFGKGFQAKIFPEILLCLLLALFASGLIHRVCVTTCFIFSMVGLYYINKISSTLYQATAPVLTPAKVTGKGKKRN", "length": 136, "header": "sp|A6QQ59-1|KTAP2_BOVIN Isoform 1 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2 OS=Bos taurus OX=9913 GN=KRTCAP2 PE=2 SV=1 CANONICAL=A6QQ59-1" }, "locus": { "chromosome": "3", "start_pos": 15446529, "end_pos": 15444172, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014035.6", "url": "https://www.ensembl.org/id/ENSBTAT00000014035.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014035.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014035.6" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 124, "end_pos": 124, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A6QQ59", "url": "https://www.uniprot.org/uniprotkb/A6QQ59" } ], "site_lbl": "Thr124" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540389", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540389", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B2RZC9-1", "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2", "gene_name": "Krtcap2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVVGTGTSLALSSLLSLLLFAGMQIYSRQLASTEWLTIQGGLLGSGLFVFSLTAFNNLENLVFGKGFQAKIFPEILLCLLLALFASGLIHRVCVTTCFIFSMVGLYYINKISSTLYQATAPALTPAKVTGKSKKRN", "length": 136 }, "evidence": [ { "id": "A6QQ59", "url": "https://omabrowser.org/oma/group/A6QQ59/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HC53-1", "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2", "gene_name": "Krtcap2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVVGTGTSLALSSLLSLLLFAGMQIYSRQLASTEWLTIQGGLLGSGLFVFSLTAFNNLENLVFGKGFQAKIFPEILICLLLALFASGLIHRVCVTTCFIFSMVGLYYINKISSTLYQVTAPVLTPAKVTGKGKKRN", "length": 136 }, "evidence": [ { "id": "A6QQ59", "url": "https://omabrowser.org/oma/group/A6QQ59/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q54L98-1", "protein_name": "Protein KRTCAP2 homolog", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MASRQPSEGSTVLISLILWVIIFALLNIGSNFFRSSEGATILGGFVGSFLFFLQMTFIGAIKRDVKLLETVLAVIITAMISSSVHRVSGTTSIIFSIGWIFYLNHASTKIYSKLEETNTVVSGKKRK", "length": 127 }, "evidence": [ { "id": "A6QQ59", "url": "https://omabrowser.org/oma/group/A6QQ59/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5RL79-1", "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2", "gene_name": "Krtcap2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVVGTGTSLALSSLLSLLLFAGMQIYSRQLASTEWLTIQGGLLGSGLFVFSLTAFNNLENLVFGKGFQAKIFPEILLCLLLALFASGLIHRVCVTTCFIFSMVGLYYINKISSTLYQATAPVLTPAKITGKGKKRN", "length": 136 }, "evidence": [ { "id": "A6QQ59", "url": "https://omabrowser.org/oma/group/A6QQ59/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8INQ7-1", "protein_name": "Protein KRTCAP2 homolog", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSASVSSKSTVVSSIISGLLSIVLFGTLRFCSEWFNDSQLRVLLGGYLFSWVFILSLTCVSNAEMVVFGQDFQAKLLPEIIFCLSLTVAAAGLVHRVCATTSVLFSLVGLYFLNRISTKYYSVQVPSVDAPTTRKGGKKFK", "length": 141 }, "evidence": [ { "id": "A6QQ59", "url": "https://omabrowser.org/oma/group/A6QQ59/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q8N6L1-1", "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2", "gene_name": "KRTCAP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVVGTGTSLALSSLLSLLLFAGMQMYSRQLASTEWLTIQGGLLGSGLFVFSLTAFNNLENLVFGKGFQAKIFPEILLCLLLALFASGLIHRVCVTTCFIFSMVGLYYINKISSTLYQAAAPVLTPAKVTGKSKKRN", "length": 136 }, "evidence": [ { "id": "A6QQ59", "url": "https://omabrowser.org/oma/group/A6QQ59/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9FVX3-1", "protein_name": "Keratinocyte-associated-like protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAGAVGTSMLGSLIVFTVILSLQEIYRGKLASSELFTILGGFTSSLLFLFSLTFIGNFQESSGIKSGWGAVILAEIIALIAAGTVHRVCITTCFLFSAGLLYEVNKISGYMLSKTESKSKRH", "length": 122 }, "evidence": [ { "id": "A6QQ59", "url": "https://omabrowser.org/oma/group/A6QQ59/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A6QQ59", "url": "https://www.uniprot.org/uniprotkb/A6QQ59" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A6QQ59", "url": "https://www.uniprot.org/uniprotkb/A6QQ59" } ], "pmid": "" }, { "name": "oligosaccharyltransferase complex A", "id": "GO:0160226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160226", "evidence": [ { "database": "UniProtKB", "id": "A6QQ59", "url": "https://www.uniprot.org/uniprotkb/A6QQ59" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein N-linked glycosylation", "id": "GO:0006487", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006487", "evidence": [ { "database": "UniProtKB", "id": "A6QQ59", "url": "https://www.uniprot.org/uniprotkb/A6QQ59" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "enzyme activator activity", "id": "GO:0008047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008047", "evidence": [ { "database": "UniProtKB", "id": "A6QQ59", "url": "https://www.uniprot.org/uniprotkb/A6QQ59" } ], "pmid": "" }, { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "A6QQ59", "url": "https://www.uniprot.org/uniprotkb/A6QQ59" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QQ59-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 136, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QQ59-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QQ59" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A6QQ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ59" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Prevents secretion from ER", "eco_id": "ECO_0000255", "start_pos": 133, "end_pos": 136, "start_aa": "Lys", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 124 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6H7F7-1", "uniprot_ac": "A6H7F7", "uniprot_id": "TPC2L_BOVIN", "mass": { "chemical_mass": 16000.0, "monoisotopic_mass": 16000.0 }, "refseq": { "ac": "NP_001092390", "name": "trafficking protein particle complex subunit 2-like protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092390" }, "gene_names": [ { "name": "TRAPPC2L", "type": "recommended", "evidence": [ { "id": "A6H7F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7F7" } ] }, { "name": "TRAPPC2L", "type": "synonym", "evidence": [ { "id": "NP_001092390", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092390" } ] } ], "protein_names": [ { "name": "Trafficking protein particle complex subunit 2-like protein", "type": "recommended", "evidence": [ { "id": "A6H7F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7F7/entry#names_and_taxonomy" } ] }, { "name": "trafficking protein particle complex 2 like", "type": "synonym", "evidence": [ { "id": "NP_001092390", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092390" } ] }, { "name": "trafficking protein particle complex subunit 2-like protein", "type": "synonym", "evidence": [ { "id": "NP_001092390", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092390" } ] } ], "function": [ { "annotation": "May play a role in vesicular transport from endoplasmic reticulum to Golgi.", "evidence": [ { "database": "UniProtKB", "id": "A6H7F7", "url": "https://www.uniprot.org/uniprotkb/A6H7F7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6H7F7", "url": "https://www.uniprot.org/uniprotkb/A6H7F7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRAPPC2L", "url": "https://www.uniprot.org/uniprotkb/A6H7F7", "locus": { "chromosome": "18", "start_pos": 14041333, "end_pos": 14032588, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019184", "url": "https://www.ensembl.org/id/ENSBTAG00000019184" } ] } } ], "crossref": [ { "id": "A6H7F7", "url": "https://alphafold.ebi.ac.uk/entry/A6H7F7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019184", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019184", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14854", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14854", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509955", "url": "https://www.ncbi.nlm.nih.gov/gene/509955", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006722", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006722", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044760", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509955", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509955", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QNPFYEP", "url": "https://omabrowser.org/oma/group/QNPFYEP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6H7F7", "url": "https://www.orthodb.org/?gene=A6H7F7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12403", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12403", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001092390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092390", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RW57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW57", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RW57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW57-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7Q8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Q8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7Q8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7Q8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNC0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNC0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQP8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQP8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQP8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVD7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVD7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TX52", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TX52-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX52-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6H7F7", "url": "https://www.uniprot.org/uniprotkb/A6H7F7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6H7F7-1", "url": "https://www.uniprot.org/uniprotkb/A6H7F7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVCVAVIAKENYPLYIRSIPTENELKFHYMVHTSLDVVDEKISAMGKALVDQRELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDGMVTSMMIQVC", "length": 139, "header": "sp|A6H7F7-1|TPC2L_BOVIN Isoform 1 of Trafficking protein particle complex subunit 2-like protein OS=Bos taurus OX=9913 GN=TRAPPC2L PE=2 SV=1 CANONICAL=A6H7F7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RW57-1", "url": "https://www.uniprot.org/uniprotkb/A6H7F7/entry#A0AAA9RW57-1", "sequence": { "sequence": "DALSTIILFLQNYPLYIRSIPTENELKFHYMVHTSLDVVDEKISAMGKALVDQRELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDGMVTSMMIQVC", "length": 139, "header": "tr|A0AAA9RW57-1|TPC2L_BOVIN Computationally mapped isoform of Trafficking protein particle complex subunit 2-like protein OS=Bos taurus OX=9913 GN=TRAPPC2L PE=2 SV=1 CANONICAL=A6H7F7-1" }, "locus": { "chromosome": "18", "start_pos": 14036982, "end_pos": 14034377, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124688.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124688.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075345.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075345.1" } ] } }, { "isoform_ac": "A0AAA9S7Q8-1", "url": "https://www.uniprot.org/uniprotkb/A6H7F7/entry#A0AAA9S7Q8-1", "sequence": { "sequence": "MAVCVAVIAKENYPLYIRSIPTENELKFHYMVHTSLDVVDEKISAMGKALVDQRELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDGMVTSMMIQARRGKESLVARAPGAWSPEEAAKGGAEDL", "length": 166, "header": "tr|A0AAA9S7Q8-1|TPC2L_BOVIN Computationally mapped isoform of Trafficking protein particle complex subunit 2-like protein OS=Bos taurus OX=9913 GN=TRAPPC2L PE=2 SV=1 CANONICAL=A6H7F7-1" }, "locus": { "chromosome": "18", "start_pos": 14037463, "end_pos": 14032594, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098641.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098641.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078186.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078186.1" } ] } }, { "isoform_ac": "A0AAA9SNC0-1", "url": "https://www.uniprot.org/uniprotkb/A6H7F7/entry#A0AAA9SNC0-1", "sequence": { "sequence": "MAVCVAVIAKENYPLYIRSIPTENELKFHYMVHTSLDVVDEKISAMGKALVDQRELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRWTKRMLRVLASSGHS", "length": 140, "header": "tr|A0AAA9SNC0-1|TPC2L_BOVIN Computationally mapped isoform of Trafficking protein particle complex subunit 2-like protein OS=Bos taurus OX=9913 GN=TRAPPC2L PE=2 SV=1 CANONICAL=A6H7F7-1" }, "locus": { "chromosome": "18", "start_pos": 14038977, "end_pos": 14032594, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115879.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115879.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085462.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085462.1" } ] } }, { "isoform_ac": "A0AAA9TQP8-1", "url": "https://www.uniprot.org/uniprotkb/A6H7F7/entry#A0AAA9TQP8-1", "sequence": { "sequence": "MAVCVAVIAKENYPLYIRSIPTENELKFHYMVHTSLDVVDEKISAMGKALVDQRELYLGLLYPTEDYKLTLWARNW", "length": 76, "header": "tr|A0AAA9TQP8-1|TPC2L_BOVIN Computationally mapped isoform of Trafficking protein particle complex subunit 2-like protein OS=Bos taurus OX=9913 GN=TRAPPC2L PE=2 SV=1 CANONICAL=A6H7F7-1" }, "locus": { "chromosome": "18", "start_pos": 14035524, "end_pos": 14032594, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106331.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106331.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100697.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100697.1" } ] } }, { "isoform_ac": "A0AAA9TVD7-1", "url": "https://www.uniprot.org/uniprotkb/A6H7F7/entry#A0AAA9TVD7-1", "sequence": { "sequence": "MAVCVAVIAKENYPLYIRSIPTENELKFHYMVHTSLDVVDEKISAMGKALVDQRELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRR", "length": 126, "header": "tr|A0AAA9TVD7-1|TPC2L_BOVIN Computationally mapped isoform of Trafficking protein particle complex subunit 2-like protein OS=Bos taurus OX=9913 GN=TRAPPC2L PE=2 SV=1 CANONICAL=A6H7F7-1" }, "locus": { "chromosome": "18", "start_pos": 14041007, "end_pos": 14032594, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129541.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129541.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100530.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100530.1" } ] } }, { "isoform_ac": "A0AAA9TX52-1", "url": "https://www.uniprot.org/uniprotkb/A6H7F7/entry#A0AAA9TX52-1", "sequence": { "sequence": "MAVCVAVIAKENYPLYIRSIPTENELKFHYMVHTSLDVVDEKISAMGKALVDQRELYLGLLYPTEDYKMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDGMVTSMMIQVC", "length": 109, "header": "tr|A0AAA9TX52-1|TPC2L_BOVIN Computationally mapped isoform of Trafficking protein particle complex subunit 2-like protein OS=Bos taurus OX=9913 GN=TRAPPC2L PE=2 SV=1 CANONICAL=A6H7F7-1" }, "locus": { "chromosome": "18", "start_pos": 14036982, "end_pos": 14032594, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135325.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135325.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103228.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103228.1" } ] } }, { "isoform_ac": "A6H7F7-1", "url": "https://www.uniprot.org/uniprotkb/A6H7F7/entry#A6H7F7-1", "sequence": { "sequence": "MAVCVAVIAKENYPLYIRSIPTENELKFHYMVHTSLDVVDEKISAMGKALVDQRELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDGMVTSMMIQVC", "length": 139, "header": "sp|A6H7F7-1|TPC2L_BOVIN Isoform 1 of Trafficking protein particle complex subunit 2-like protein OS=Bos taurus OX=9913 GN=TRAPPC2L PE=2 SV=1 CANONICAL=A6H7F7-1" }, "locus": { "chromosome": "18", "start_pos": 14036982, "end_pos": 14032594, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025533.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025533.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025533.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025533.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509955", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509955", "resource": "KEGG Pathway" }, { "id": "R-BTA-204005", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "resource": "Reactome", "description": "COPII-mediated vesicle transport" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A2R8S035-1", "protein_name": "Trafficking protein particle complex subunit 2-like protein", "gene_name": "trappc2l", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAVCIAVIAKENYPLYIRSVPTQGELKFHYTVHTSLDVVEEKISGVGKALADQRELYLGLLYPTEDYKVYGYVTNSKVKFVIVVDSSNTSLRDNEIRSMFRKLHNSFTDVMCNPFYNPGDPIQSKAFDGIVSAMMVQAS", "length": 139 }, "evidence": [ { "id": "A6H7F7", "url": "https://omabrowser.org/oma/group/A6H7F7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0XUM7-1", "protein_name": "Trafficking protein particle complex subunit 2-like protein", "gene_name": "TRAPPC2L", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAVCIAVIAKENYPLYIRSVPTENELKFHYTVHTSLDVVDEKISAMGKAMVDQRELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDNEIRSMFRKLHNSYTDIMCNPFYNPGDRIHSRAFDNMVNSMMMQVC", "length": 139 }, "evidence": [ { "id": "A6H7F7", "url": "https://omabrowser.org/oma/group/A6H7F7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9JME7-1", "protein_name": "Trafficking protein particle complex subunit 2-like protein", "gene_name": "Trappc2l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAVCIAVIAKENYPLYIRSTPTESELKFHYMVHTSLDVVDEKISAMGKALVDQRELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDTMVTSMMIQVC", "length": 139 }, "evidence": [ { "id": "A6H7F7", "url": "https://omabrowser.org/oma/group/A6H7F7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UL33-1", "protein_name": "Trafficking protein particle complex subunit 2-like protein", "gene_name": "TRAPPC2L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAVCIAVIAKENYPLYIRSTPTENELKFHYMVHTSLDVVDEKISAMGKALVDQRELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSSRAFDNMVTSMMIQVC", "length": 140 }, "evidence": [ { "id": "A6H7F7", "url": "https://omabrowser.org/oma/group/A6H7F7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A6H7F7", "url": "https://www.uniprot.org/uniprotkb/A6H7F7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A6H7F7", "url": "https://www.uniprot.org/uniprotkb/A6H7F7" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A6H7F7", "url": "https://www.uniprot.org/uniprotkb/A6H7F7" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A6H7F7", "url": "https://www.uniprot.org/uniprotkb/A6H7F7" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A6H7F7", "url": "https://www.uniprot.org/uniprotkb/A6H7F7" } ], "pmid": "" }, { "name": "TRAPP complex", "id": "GO:0030008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030008", "evidence": [ { "database": "UniProtKB", "id": "A6H7F7", "url": "https://www.uniprot.org/uniprotkb/A6H7F7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A6H7F7", "url": "https://www.uniprot.org/uniprotkb/A6H7F7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "A6H7F7", "url": "https://www.uniprot.org/uniprotkb/A6H7F7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6H7F7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 139, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6H7F7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6H7F7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QQL9-1", "uniprot_ac": "A6QQL9", "uniprot_id": "SRP14_BOVIN", "mass": { "chemical_mass": 12461.0, "monoisotopic_mass": 12461.0 }, "refseq": { "ac": "NP_001093820", "name": "signal recognition particle 14 kDa protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093820" }, "gene_names": [ { "name": "SRP14", "type": "recommended", "evidence": [ { "id": "A6QQL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQL9" } ] }, { "name": "SRP14", "type": "synonym", "evidence": [ { "id": "NP_001093820", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093820" } ] } ], "protein_names": [ { "name": "Signal recognition particle 14 kDa protein", "type": "recommended", "evidence": [ { "id": "A6QQL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQL9/entry#names_and_taxonomy" } ] }, { "name": "SRP14", "type": "synonym", "evidence": [ { "id": "A6QQL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQL9/entry#names_and_taxonomy" } ] }, { "name": "signal recognition particle 14 kDa protein", "type": "synonym", "evidence": [ { "id": "NP_001093820", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093820" } ] }, { "name": "signal recognition particle 14kDa (homologous Alu RNA binding protein)", "type": "synonym", "evidence": [ { "id": "NP_001093820", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093820" } ] } ], "function": [ { "annotation": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity). The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A6QQL9", "url": "https://www.uniprot.org/uniprotkb/A6QQL9#function" }, { "database": "UniProtKB", "id": "P37108", "url": "https://www.uniprot.org/uniprotkb/P37108#function" }, { "database": "UniProtKB", "id": "A0AAA9S277", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S277#function" }, { "database": "UniProtKB", "id": "RU368100", "url": "https://www.uniprot.org/uniprotkb/RU368100#function" }, { "database": "UniProtKB", "id": "ARBA00045462", "url": "https://www.uniprot.org/uniprotkb/ARBA00045462#function" }, { "database": "UniProtKB", "id": "A0AAA9TQ41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ41#function" }, { "database": "UniProtKB", "id": "A0AAA9T1A9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1A9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QQL9", "url": "https://www.uniprot.org/uniprotkb/A6QQL9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SRP14", "url": "https://www.uniprot.org/uniprotkb/A6QQL9", "locus": { "chromosome": "10", "start_pos": 35688239, "end_pos": 35698923, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014353", "url": "https://www.ensembl.org/id/ENSBTAG00000014353" } ] } } ], "crossref": [ { "id": "A6QQL9", "url": "https://alphafold.ebi.ac.uk/entry/A6QQL9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014353", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014353", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512792", "url": "https://www.ncbi.nlm.nih.gov/gene/512792", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009018", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009018", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512792", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512792", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RFNGHNK", "url": "https://omabrowser.org/oma/group/RFNGHNK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QQL9", "url": "https://www.orthodb.org/?gene=A6QQL9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12013", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12013", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02290", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02290", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001093820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093820", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S277", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S277", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S277-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S277-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1A9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1A9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1A9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1A9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQL9", "url": "https://www.uniprot.org/uniprotkb/A6QQL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQL9-1", "url": "https://www.uniprot.org/uniprotkb/A6QQL9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLLESEQFLTELTRLFQKCRLSGSVFITLKKYDGRTKPIPRKGSVEGFEPSDNKCLLRATDGKKKISTVVSSKEVNKFQMAYSNLLRANMDGLKKRDKKSKSKKSKAAQ", "length": 110, "header": "sp|A6QQL9-1|SRP14_BOVIN Isoform 1 of Signal recognition particle 14 kDa protein OS=Bos taurus OX=9913 GN=SRP14 PE=3 SV=1 CANONICAL=A6QQL9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S277-1", "url": "https://www.uniprot.org/uniprotkb/A6QQL9/entry#A0AAA9S277-1", "sequence": { "sequence": "GLYSWETVTQLPATYAPKAKSHRPDCKFLTELTRLFQKCRLSGSVFITLKKYDGRTKPIPRKGSVEGFEPSDNKCLLRATDGKKKISTVVSSKEVNKFQMAYSNLLRANMDGLKKRDKKSKSKKSKAAQ", "length": 129, "header": "tr|A0AAA9S277-1|SRP14_BOVIN Computationally mapped isoform of Signal recognition particle 14 kDa protein OS=Bos taurus OX=9913 GN=SRP14 PE=3 SV=1 CANONICAL=A6QQL9-1" }, "locus": { "chromosome": "10", "start_pos": 35697617, "end_pos": 35688704, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109626.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109626.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076198.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076198.1" } ] } }, { "isoform_ac": "A0AAA9T1A9-1", "url": "https://www.uniprot.org/uniprotkb/A6QQL9/entry#A0AAA9T1A9-1", "sequence": { "sequence": "MLAVMICFCRMNLPRQTGTANSHPVSFEWIVTPTWFPHYNAKFLTELTRLFQKCRLSGSVFITLKKYDGRTKPIPRKGSVEGFEPSDNKCLLRATDGKKKISTVVSSKEVNKFQMAYSNLLRANMDGLKKRDKKSKSKKSKAAQ", "length": 144, "header": "tr|A0AAA9T1A9-1|SRP14_BOVIN Computationally mapped isoform of Signal recognition particle 14 kDa protein OS=Bos taurus OX=9913 GN=SRP14 PE=3 SV=1 CANONICAL=A6QQL9-1" }, "locus": { "chromosome": "10", "start_pos": 35698722, "end_pos": 35688704, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122666.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122666.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090182.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090182.1" } ] } }, { "isoform_ac": "A0AAA9TQ41-1", "url": "https://www.uniprot.org/uniprotkb/A6QQL9/entry#A0AAA9TQ41-1", "sequence": { "sequence": "TYLDKQEQPTPIQFLTELTRLFQKCRLSGSVFITLKKYDGRTKPIPRKGSVEGFEPSDNKCLLRATDGKKKISTVVSSKEVNKFQMAYSNLLRANMDGLKKRDKKSKSKKSKAAQ", "length": 115, "header": "tr|A0AAA9TQ41-1|SRP14_BOVIN Computationally mapped isoform of Signal recognition particle 14 kDa protein OS=Bos taurus OX=9913 GN=SRP14 PE=3 SV=1 CANONICAL=A6QQL9-1" }, "locus": { "chromosome": "10", "start_pos": 35698688, "end_pos": 35688704, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134743.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134743.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100693.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100693.1" } ] } }, { "isoform_ac": "A6QQL9-1", "url": "https://www.uniprot.org/uniprotkb/A6QQL9/entry#A6QQL9-1", "sequence": { "sequence": "MVLLESEQFLTELTRLFQKCRLSGSVFITLKKYDGRTKPIPRKGSVEGFEPSDNKCLLRATDGKKKISTVVSSKEVNKFQMAYSNLLRANMDGLKKRDKKSKSKKSKAAQ", "length": 110, "header": "sp|A6QQL9-1|SRP14_BOVIN Isoform 1 of Signal recognition particle 14 kDa protein OS=Bos taurus OX=9913 GN=SRP14 PE=3 SV=1 CANONICAL=A6QQL9-1" }, "locus": { "chromosome": "10", "start_pos": 35691442, "end_pos": 35688704, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019085.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019085.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019085.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019085.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 45, "end_pos": 45, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QQL9", "url": "https://www.uniprot.org/uniprotkb/A6QQL9" } ], "site_lbl": "Ser45" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512792", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512792", "resource": "KEGG Pathway" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2N8M7-1", "protein_name": "Signal recognition particle 14 kDa protein", "gene_name": "Srp14", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVLLESEQFLTELTRLFQKCRSSGSVYITLKKYDGRTKPTPRKSAVESVEPAENKCLLRATDGKRKISTVVSSKEVNKFQMAYSNLLRANMDGLKKRDKKNKSKKTKPAQ", "length": 110 }, "evidence": [ { "id": "A6QQL9", "url": "https://omabrowser.org/oma/group/A6QQL9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O04421-1", "protein_name": "Signal recognition particle 14 kDa protein", "gene_name": "SRP14", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVLLQLDPFLNELTSMFEKSKEKGSVWVTLKRSSLKSKVQKRKLSSVGESIEYRCLIRATDGKKTVSTSVGAKDHQRFQASYATILKAHMTALKKRERKDRKKSTEAEKKESTSTTKSKKL", "length": 121 }, "evidence": [ { "id": "A6QQL9", "url": "https://omabrowser.org/oma/group/A6QQL9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P16254-1", "protein_name": "Signal recognition particle 14 kDa protein", "gene_name": "Srp14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVLLESEQFLTELTRLFQKCRSSGSVFITLKKYDGRTKPIPRKSSVEGLEPAENKCLLRATDGKRKISTVVSSKEVNKFQMAYSNLLRANMDGLKKRDKKNKSKKSKPAQ", "length": 110 }, "evidence": [ { "id": "A6QQL9", "url": "https://omabrowser.org/oma/group/A6QQL9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P37108-1", "protein_name": "Signal recognition particle 14 kDa protein", "gene_name": "SRP14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVLLESEQFLTELTRLFQKCRTSGSVYITLKKYDGRTKPIPKKGTVEGFEPADNKCLLRATDGKKKISTVVSSKEVNKFQMAYSNLLRANMDGLKKRDKKNKTKKTKAAAAAAAAAPAAAATAPTTAATTAATAAQ", "length": 136 }, "evidence": [ { "id": "A6QQL9", "url": "https://omabrowser.org/oma/group/A6QQL9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VDL0-1", "protein_name": "Signal recognition particle 14 kDa protein", "gene_name": "Srp14", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVLLDNSNFILRLEKIANAAKKDSSFTLTFKRYDGNDKPVPREGRPPLPKPETYMCLMRAQSKSQKISTVVRQEDVPAMMSMYSQFMKSKMDGLKRVKKVKSKAKATKG", "length": 109 }, "evidence": [ { "id": "A6QQL9", "url": "https://omabrowser.org/oma/group/A6QQL9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "signal recognition particle, endoplasmic reticulum targeting", "id": "GO:0005786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005786", "evidence": [ { "database": "UniProtKB", "id": "A6QQL9", "url": "https://www.uniprot.org/uniprotkb/A6QQL9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A6QQL9", "url": "https://www.uniprot.org/uniprotkb/A6QQL9" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A6QQL9", "url": "https://www.uniprot.org/uniprotkb/A6QQL9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum signal peptide binding", "id": "GO:0030942", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030942", "evidence": [ { "database": "UniProtKB", "id": "A6QQL9", "url": "https://www.uniprot.org/uniprotkb/A6QQL9" } ], "pmid": "" }, { "name": "7S RNA binding", "id": "GO:0008312", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008312", "evidence": [ { "database": "UniProtKB", "id": "A6QQL9", "url": "https://www.uniprot.org/uniprotkb/A6QQL9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "SRP-dependent cotranslational protein targeting to membrane", "id": "GO:0006614", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006614", "evidence": [ { "database": "UniProtKB", "id": "A6QQL9", "url": "https://www.uniprot.org/uniprotkb/A6QQL9" } ], "pmid": "" }, { "name": "protein targeting to ER", "id": "GO:0045047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045047", "evidence": [ { "database": "UniProtKB", "id": "A6QQL9", "url": "https://www.uniprot.org/uniprotkb/A6QQL9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QQL9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 110, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QQL9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QQL9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 45 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QLS2-1", "uniprot_ac": "A6QLS2", "uniprot_id": "RSRC2_BOVIN", "mass": { "chemical_mass": 50578.0, "monoisotopic_mass": 50578.0 }, "refseq": { "ac": "NP_001095616", "name": "arginine/serine-rich coiled-coil protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095616" }, "gene_names": [ { "name": "RSRC2", "type": "recommended", "evidence": [ { "id": "A6QLS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLS2" } ] }, { "name": "RSRC2", "type": "synonym", "evidence": [ { "id": "NP_001095616", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095616" } ] } ], "protein_names": [ { "name": "Arginine/serine-rich coiled-coil protein 2", "type": "recommended", "evidence": [ { "id": "A6QLS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLS2/entry#names_and_taxonomy" } ] }, { "name": "arginine/serine-rich coiled-coil 2", "type": "synonym", "evidence": [ { "id": "NP_001095616", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095616" } ] }, { "name": "arginine/serine-rich coiled-coil protein 2", "type": "synonym", "evidence": [ { "id": "NP_001095616", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095616" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QLS2", "url": "https://www.uniprot.org/uniprotkb/A6QLS2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RSRC2", "url": "https://www.uniprot.org/uniprotkb/A6QLS2", "locus": { "chromosome": "17", "start_pos": 52941012, "end_pos": 52925068, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006118", "url": "https://www.ensembl.org/id/ENSBTAG00000006118" } ] } } ], "crossref": [ { "id": "A6QLS2", "url": "https://alphafold.ebi.ac.uk/entry/A6QLS2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006118", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006118", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532701", "url": "https://www.ncbi.nlm.nih.gov/gene/532701", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028124", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028124", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532701", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532701", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QEEMFKN", "url": "https://omabrowser.org/oma/group/QEEMFKN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QLS2", "url": "https://www.orthodb.org/?gene=A6QLS2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22426", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22426", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22426:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22426:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15477", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15477", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095616", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S3A8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3A8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3A8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3A8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZJN1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZJN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZJN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QLS2", "url": "https://www.uniprot.org/uniprotkb/A6QLS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QLS2-1", "url": "https://www.uniprot.org/uniprotkb/A6QLS2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QLS2-2", "url": "https://www.uniprot.org/uniprotkb/A6QLS2-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASDTERDGLAPEKTSPDTDKKKEQSDVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEARRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRDRKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHRSRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQEIAAAAAATGGSVLNVAALLASGTQVTPQIAMAAQMAALQAKALAETGIAVPSYYNPAAVNPMKFAEQEKKRKMLWQGKKEGDKSQSAEIWEKLNFGNKDQNVKFRKLMGIKSEDEAGCSSVDEESYKTLKQQEEVFRNLDAQYEMARSQTHTQRGMGLGFTSSMRGMDTV", "length": 435, "header": "sp|A6QLS2-1|RSRC2_BOVIN Isoform 1 of Arginine/serine-rich coiled-coil protein 2 OS=Bos taurus OX=9913 GN=RSRC2 PE=2 SV=2 CANONICAL=A6QLS2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S3A8-1", "url": "https://www.uniprot.org/uniprotkb/A6QLS2/entry#A0AAA9S3A8-1", "sequence": { "sequence": "ERTNFFLKQARRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRDRKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHRSRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQEIAAAAAATGGSVLNVAALLASGTQVTPQIAMAAQMAALQAKALAETGIAVPSYYNPAAVNPMKFAEQEKKRKMLWQGKKEGDKSQSAEIWEKLNFGNKDQNVKFRKLMGIKSEDEAGCSSVDEESYKTLKQQEEVFRNLDAQYEMARSQTHTQRGMGLGFTSSMRGMDTV", "length": 375, "header": "tr|A0AAA9S3A8-1|RSRC2_BOVIN Computationally mapped isoform of Arginine/serine-rich coiled-coil protein 2 OS=Bos taurus OX=9913 GN=RSRC2 PE=2 SV=1 CANONICAL=A6QLS2-1" }, "locus": { "chromosome": "17", "start_pos": 52940206, "end_pos": 52932540, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110891.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110891.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078249.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078249.1" } ] } }, { "isoform_ac": "A0AAF6ZJN1-1", "url": "https://www.uniprot.org/uniprotkb/A6QLS2/entry#A0AAF6ZJN1-1", "sequence": { "sequence": "MAASDTERDGLAPEKTSPDTDKKKEQSDVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEARRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRDRKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHRSRSRSRTRSRSRPILDCRATREAHILTYTCVKLLIDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQEIAAAAAATGGSVLNVAALLASGTQVTPQIAMAAQMAALQAKALAETGIAVPSYYNPAAVNPMKFAEQEKKRKMLWQGKKEGDKSQSAEIWEKLNFGNKDQNVKFRKLMGIKSEDEAGCSSVDEESYKTLKQQEEVFRNLDAQYEMARSQTHTQRGMGLGFTSSMRGMDTV", "length": 458, "header": "tr|A0AAF6ZJN1-1|RSRC2_BOVIN Computationally mapped isoform of Arginine/serine-rich coiled-coil protein 2 OS=Bos taurus OX=9913 GN=RSRC2 PE=2 SV=1 CANONICAL=A6QLS2-1" }, "locus": { "chromosome": "17", "start_pos": 52940206, "end_pos": 52925164, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055724.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055724.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049555.3", "url": "https://www.ensembl.org/id/ENSBTAP00000049555.3" } ] } }, { "isoform_ac": "A6QLS2-1", "url": "https://www.uniprot.org/uniprotkb/A6QLS2/entry#A6QLS2-1", "sequence": { "sequence": "MAASDTERDGLAPEKTSPDTDKKKEQSDVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEARRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRDRKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHRSRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQEIAAAAAATGGSVLNVAALLASGTQVTPQIAMAAQMAALQAKALAETGIAVPSYYNPAAVNPMKFAEQEKKRKMLWQGKKEGDKSQSAEIWEKLNFGNKDQNVKFRKLMGIKSEDEAGCSSVDEESYKTLKQQEEVFRNLDAQYEMARSQTHTQRGMGLGFTSSMRGMDTV", "length": 435, "header": "sp|A6QLS2-1|RSRC2_BOVIN Isoform 1 of Arginine/serine-rich coiled-coil protein 2 OS=Bos taurus OX=9913 GN=RSRC2 PE=2 SV=2 CANONICAL=A6QLS2-1" }, "locus": {} }, { "isoform_ac": "A6QLS2-2", "url": "https://www.uniprot.org/uniprotkb/A6QLS2/entry#A6QLS2-2", "sequence": { "sequence": "MIRTNFFLKQARRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRDRKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHRSRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQEIAAAAAATGGSVLNVAALLASGTQVTPQIAMAAQMAALQAKALAETGIAVPSYYNPAAVNPMKFAEQEKKRKMLWQGKKEGDKSQSAEIWEKLNFGNKDQNVKFRKLMGIKSEDEAGCSSVDEESYKTLKQQEEVFRNLDAQYEMARSQTHTQRGMGLGFTSSMRGMDTV", "length": 376, "header": "sp|A6QLS2-2|RSRC2_BOVIN Isoform 2 of Arginine/serine-rich coiled-coil protein 2 OS=Bos taurus OX=9913 GN=RSRC2 PE=2 SV=2 CANONICAL=A6QLS2-1" }, "locus": { "chromosome": "17", "start_pos": 52940206, "end_pos": 52931006, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008042.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008042.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008042.5", "url": "https://www.ensembl.org/id/ENSBTAP00000008042.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 104, "end_pos": 104, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QLS2", "url": "https://www.uniprot.org/uniprotkb/A6QLS2" } ], "site_lbl": "Ser104" }, { "start_pos": 16, "end_pos": 16, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A6QLS2", "url": "https://www.uniprot.org/uniprotkb/A6QLS2" } ], "site_lbl": "Thr16" }, { "start_pos": 17, "end_pos": 17, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QLS2", "url": "https://www.uniprot.org/uniprotkb/A6QLS2" } ], "site_lbl": "Ser17" }, { "start_pos": 30, "end_pos": 30, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QLS2", "url": "https://www.uniprot.org/uniprotkb/A6QLS2" } ], "site_lbl": "Ser30" }, { "start_pos": 32, "end_pos": 32, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QLS2", "url": "https://www.uniprot.org/uniprotkb/A6QLS2" } ], "site_lbl": "Ser32" }, { "start_pos": 377, "end_pos": 377, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QLS2", "url": "https://www.uniprot.org/uniprotkb/A6QLS2" } ], "site_lbl": "Ser377" }, { "start_pos": 4, "end_pos": 4, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QLS2", "url": "https://www.uniprot.org/uniprotkb/A6QLS2" } ], "site_lbl": "Ser4" }, { "start_pos": 6, "end_pos": 6, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A6QLS2", "url": "https://www.uniprot.org/uniprotkb/A6QLS2" } ], "site_lbl": "Thr6" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "A6QLS2", "url": "https://www.uniprot.org/uniprotkb/A6QLS2" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:532701", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532701", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B2I4-1", "protein_name": "Arginine/serine-rich coiled-coil protein 2", "gene_name": "RSRC2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAASDTERDGLAPEKTSPDREKKKEQSDVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEARRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHRSRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQEMAAAAAATGGSVLNVAALLASGTQVTPQIAMAAQMAALQAKALAETGIAVPSYYNPAAVNPMKFAEQEKKRKMLWQGKKEGDKSQSAEIWEKLNFGNKDQNVKFRKLMGIKSEDEAGCSSVDEESYKTLKQQEEVFRNLDAQYEMARSQTHTQRGMGLGFTSSMRGMDAV", "length": 435 }, "evidence": [ { "id": "A6QLS2", "url": "https://omabrowser.org/oma/group/A6QLS2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZY10-1", "protein_name": "Arginine/serine-rich coiled-coil protein 2", "gene_name": "RSRC2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "GSGSGSRERGERSGPPHFWGSDTERDGVVPEKSSPEREKKKEQSDASSSPRTSKHHYSRSRSRSRERRRKSDAEGRKHRSRSRSKEARRHESKEKSSKKHKSEDHNDKEHSSDKGRESLNSSENGEDRHKRKERKSSRGRSHSRSRSRERRHRSRSRDRKKSRSRSRERKRRVRSRSRSRSRHRHRSRSRSRTRSRSRERKKRIEKPRRFSRSHSRSPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQEMAAAAAATGGSVINVAALLASGTQVTPQIAMAAQMAALQAKALAETGIAVPSYYNPAAVNPMKFAEQEKKRKMLWQGKKEGDKSQSAEIWEKLNFGNKDQNVKFRKLMGIKSEDEAGCSSVDEESYKTLKQQEEVFRNLDAQYEMARSQTHTQRGMGLGFTSSMRGMDAV", "length": 432 }, "evidence": [ { "id": "A6QLS2", "url": "https://omabrowser.org/oma/group/A6QLS2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q5PQR4-1", "protein_name": "Arginine/serine-rich coiled-coil protein 2", "gene_name": "Rsrc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIRTNFLLKQARRHESKDKSSKRHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRDRKKSRSRSRDRKKSRSRSRDRKRRIRTRSRSRSRHRHRTRSRSRSRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQEMAAAAAATGGSVLNVAALLASGTQVTPQIAMAAQMAALQAKALAETGIAVPSYYNPAAVNPMKFAEQEKKRKMLWQGKKEGDKSQSAEIWEKLNFGNKDQNVKFRKLMGIKSEDEAGCSSVDEESYKTLKQQEEVFRNLDAQYEMARSQTHTQRGMGLGFTSSMRGMDTV", "length": 376 }, "evidence": [ { "id": "A6QLS2", "url": "https://omabrowser.org/oma/group/A6QLS2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6NWI1-1", "protein_name": "Arginine/serine-rich coiled-coil protein 2", "gene_name": "rsrc2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAANDAELHDSFSGKSQPGENRKASRSSKHCSRSRSRSTERKRKSGDKRHKRSHSRSKEARKKDSEKALKCQSGSEERLEFSDKGRDRLSEDTEERHRRKDKKTSRPRSHSRSRSKEKRHHNRNWDKRRSRSRSRSRDKKRRARSRSNSRSKHRHRSRSRSKSREKKKRIEKSRKKSRSPSISPVTFRGRNTAMDAQEALARRLERAKKLQEQKEKDMLEKWQHQEKAAASTPQCDPAAAAPSPALNVAALLASGTQVTPQIAMAAQMAALQAKTLAETGIAVPSYYNPSAVNPMKFAEQEKKRKMLWQGKKEGDNKSQTAELWEKLNFGNKDQNVKFRKLMGIKGEEEAASSAAVNEDGLKTLQQQEEMFRNLDVQYEMARSQTHTQRGMGLGFSSSFSSRGMDAV", "length": 407 }, "evidence": [ { "id": "A6QLS2", "url": "https://omabrowser.org/oma/group/A6QLS2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q7L4I2-1", "protein_name": "Arginine/serine-rich coiled-coil protein 2", "gene_name": "RSRC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAASDTERDGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQEIAAAAATGGSVLNVAALLASGTQVTPQIAMAAQMAALQAKALAETGIAVPSYYNPAAVNPMKFAEQEKKRKMLWQGKKEGDKSQSAEIWEKLNFGNKDQNVKFRKLMGIKSEDEAGCSSVDEESYKTLKQQEEVFRNLDAQYEMARSQTHTQRGMGLGFTSSMRGMDAV", "length": 434 }, "evidence": [ { "id": "A6QLS2", "url": "https://omabrowser.org/oma/group/A6QLS2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QLS2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 435, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QLS2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QLS2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 4, 6, 16, 17, 30, 32, 104, 377 ], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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CANONICAL=A6QLZ5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5F2-1", "url": "https://www.uniprot.org/uniprotkb/A6QLZ5/entry#A0AAA9S5F2-1", "sequence": { "sequence": "MALPETSSCAQSCAESCLALWDPMDSSPAGSSLHGIFQMSNERGFENVELGVIGKKKKVPRRVIHFVSGETMEEYSTDEDEVDSLEKKDVLPPVDPTKLTWGPYLWFHMLRAATSTLSVCDFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAERQYQQNKLQADSVVQSDQPETLASSSFVNLNFEMEGDCEVITESKQNPVSVPL", "length": 219, "header": "tr|A0AAA9S5F2-1|F177A_BOVIN Computationally mapped isoform of Protein FAM177A1 OS=Bos taurus OX=9913 GN=FAM177A1 PE=2 SV=1 CANONICAL=A6QLZ5-1" }, "locus": { "chromosome": "21", "start_pos": 45367177, "end_pos": 45354017, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096030.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096030.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080423.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080423.1" } ] } }, { "isoform_ac": "A0AAA9SY66-1", "url": 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"MELFFTVSLPLSVGWREGANAPLVAAQLGNASADSAADSREASSVAGSCAQSCAESCLALWDPMDSSPAGSSLHGIFQTKLTWGPYLWFHMLRAATSTLSVCDFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAERQYQQNKLQADSVVQSDQPETLASSSFVNLNFEMEGDCEVITESKQNPVSVPL", "length": 201, "header": "tr|A0AAA9TK97-1|F177A_BOVIN Computationally mapped isoform of Protein FAM177A1 OS=Bos taurus OX=9913 GN=FAM177A1 PE=2 SV=1 CANONICAL=A6QLZ5-1" }, "locus": { "chromosome": "21", "start_pos": 45367177, "end_pos": 45353234, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108181.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108181.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098875.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098875.1" } ] } }, { "isoform_ac": "A0AAA9TZK1-1", "url": "https://www.uniprot.org/uniprotkb/A6QLZ5/entry#A0AAA9TZK1-1", "sequence": { "sequence": "MELFFTVSLPLSVGWREGANAPLVAAQLGNASADSAADSREASSVAGSCAQSCAESCLALWDPMDSSPAGSSLHGIFQMSNERGFENVELGVIGKKKKVPRRVIHFVSGETMEEYSTDEDEVDSLEKKDVLPPVDPTKLTWGPYLWFHMLRAATSTLSVCDFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAERQYQQNKLQADSVVQSDQPETLASSSFVNLNFEMEGDCEVITESKQNPVSVPL", "length": 259, "header": "tr|A0AAA9TZK1-1|F177A_BOVIN Computationally mapped isoform of Protein FAM177A1 OS=Bos taurus OX=9913 GN=FAM177A1 PE=2 SV=1 CANONICAL=A6QLZ5-1" }, "locus": { "chromosome": "21", "start_pos": 45367177, "end_pos": 45353234, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129345.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129345.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103005.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103005.1" } ] } }, { "isoform_ac": "A6QLZ5-1", "url": "https://www.uniprot.org/uniprotkb/A6QLZ5/entry#A6QLZ5-1", "sequence": { "sequence": "MEGEPASREEGEAVNASGAAAASAFRESAQQMSNERGFENVELGVIGKKKKVPRRVIHFVSGETMEEYSTDEDEVDSLEKKDVLPPVDPTKLTWGPYLWFHMLRAATSTLSVCDFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAERQYQQNKLQADSVVQSDQPETLASSSFVNLNFEMEGDCEVITESKQNPVSVPL", "length": 212, "header": "sp|A6QLZ5-1|F177A_BOVIN Isoform 1 of Protein FAM177A1 OS=Bos taurus OX=9913 GN=FAM177A1 PE=2 SV=1 CANONICAL=A6QLZ5-1" }, "locus": { "chromosome": "21", "start_pos": 45367177, "end_pos": 45353000, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012768.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012768.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012768.4", "url": "https://www.ensembl.org/id/ENSBTAP00000012768.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 69, "end_pos": 69, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QLZ5", "url": 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"evidence": [ { "id": "A6QLZ5", "url": "https://omabrowser.org/oma/group/A6QLZ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8BR63-1", "protein_name": "Protein FAM177A", "gene_name": "Fam177a2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERESGCAAAGETEAAAATAFRDATRQISNERGFENVELGVMGKKKKVPRRVIHFVSGETMEEYSTDEDEVDGLDKKDVLPTVDPTKLTWGPYLWFYMLRAATSTLSVCDFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAERQYQQNKLQADSIVQTDQPETVSSSFVNINFEMEEDCEAIKENKQRPVSVPP", "length": 207 }, "evidence": [ { "id": "A6QLZ5", "url": "https://omabrowser.org/oma/group/A6QLZ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A6QLZ5", "url": "https://www.uniprot.org/uniprotkb/A6QLZ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QLZ5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 212, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QLZ5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QLZ5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], 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Classification" ] }, { "id": "IPR010507", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010507", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011017", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011017", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051284", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051284", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536389", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536389", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QSCVNEY", "url": "https://omabrowser.org/oma/group/QSCVNEY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QPH9", "url": "https://www.orthodb.org/?gene=A6QPH9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45736", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45736", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45736:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45736:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06467", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06467", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001181947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181947", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SB88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB88-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QPH9", "url": "https://www.uniprot.org/uniprotkb/A6QPH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QPH9-1", "url": "https://www.uniprot.org/uniprotkb/A6QPH9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGECSAGRLDLTEQTPILLGSKAMAASLMDVGDSFGDPASPLVNRSRNSLVEGDNGDDDDVVFIESIQPPSSSAPVIADQRHFVFPASRNKKLQGHYSVILPSSRYLASQKGNTSETIVIDDEEDMETNGREKTVSSSFIEWGFPGTKNRTKDLDFSTSSLSRSKTKTAVGPFNPGRMNVAGGEFQNGGFTTHHSPDSWISQSASFPRNQKQPGVDSLSPVASLPKQIFQSSAQQQPTKAAKITCANCKKPLQKGQTAYQRKGSAHLFCSTTCLSSFSHKRTPKKRNVTCKKDAPTKKATVVPQGESSEPFPKCFSTSHLSPYEDSQNLRKRVLNKSRCTICNKLTEIRHEVSVNNVTHKLCSNQCFNKYRLANGLVMNCCEQCGEYLPGKGAGNNVLVIEGQQMRFCCQSCVNEYKQMIETNLKKILASENRKRNAVGEENERELYGSLNILPEKTEEIPEKKEKTSELQVSAECSLDASVVQQNVNLPPSVSDIADKLQEQLGEKPSEDSIIPAVLSADPGTWPRILSIKQRDTLVENDPPQVRNFNFPKDSTGRKFSETYYTRILANGEKTTRSWLLYSTSKDSVFCLYCKLFGEGKNQLKNENGCRDWQHLSHILSKHEESEMHINNSVKYSKLKSDLKTSKIVEASEHRLQEREGKDGVKLLYTLDLI", "length": 673, "header": "sp|A6QPH9-1|ZMYM5_BOVIN Isoform 1 of Zinc finger MYM-type protein 5 OS=Bos taurus OX=9913 GN=ZMYM5 PE=2 SV=2 CANONICAL=A6QPH9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SB88-1", "url": "https://www.uniprot.org/uniprotkb/A6QPH9/entry#A0AAA9SB88-1", "sequence": { "sequence": "MGECSAGRLDLTEQTPILLGSKAMAASLMDVGDSFGDPASPLVNRSRNSLVEGDNGDDDDVVFIESIQPPSSSAPVIADQRHFVFPASRNKKLQGHYSVILPSSRYLASQKGNTSETIVIDDEEDMETNGREKTVSSSFIEWGFPGTKNRTKDLDFSTSSLSRSKTKTAVGPFNPGRMNVAGGEFQNGGFTTHHSPEMHLPKKLLLFLKGSQVNPSQNVLVHLICLPMKTARIFEKEF", "length": 238, "header": "tr|A0AAA9SB88-1|ZMYM5_BOVIN Computationally mapped isoform of Zinc finger MYM-type protein 5 OS=Bos taurus OX=9913 GN=ZMYM5 PE=2 SV=1 CANONICAL=A6QPH9-1" }, "locus": { "chromosome": "12", "start_pos": 36256017, "end_pos": 36244019, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094912.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094912.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080732.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080732.1" } ] } }, { "isoform_ac": "A0AAA9SCN3-1", "url": "https://www.uniprot.org/uniprotkb/A6QPH9/entry#A0AAA9SCN3-1", "sequence": { "sequence": "MGECSAGRLDLTEQTPILLGSKAMAASLMDVGDSFGDPASPLVNRSRNSLVEGDNGDDDDVVFIESIQPPSSSAPVIADQRHFVFPASRNKKLQGHYSVILPSSRYLASQKGNTSETIVIDDEEDMETNGREKTVSSSFIEWGFPGTKNRTKDLDFSTSSLSRSKTKTAVGPFNPGRMNVAGGEFQNGGFTTHHSPDSWISQSASFPRNQKQPGVDSLSPVASLPKQIFQSSAQQQPTKAAKITCANCKKPLQKGQTAYQRKGSAHLFCSTTCLSSFSHKRTPKKRNVTCKKDAPTKKATVVPQGESSEPFPKCFSTSHLSPYEDSQNLRKRVLNKSRCTICNKLTEVWSFKLLSRLTRIILTFRCYCMFCDLPNRCVLNSL", "length": 382, "header": "tr|A0AAA9SCN3-1|ZMYM5_BOVIN Computationally mapped isoform of Zinc finger MYM-type protein 5 OS=Bos taurus OX=9913 GN=ZMYM5 PE=2 SV=1 CANONICAL=A6QPH9-1" }, "locus": { "chromosome": "12", "start_pos": 36256167, "end_pos": 36244019, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100612.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100612.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080035.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080035.1" } ] } }, { "isoform_ac": "A6QPH9-1", "url": "https://www.uniprot.org/uniprotkb/A6QPH9/entry#A6QPH9-1", "sequence": { "sequence": "MGECSAGRLDLTEQTPILLGSKAMAASLMDVGDSFGDPASPLVNRSRNSLVEGDNGDDDDVVFIESIQPPSSSAPVIADQRHFVFPASRNKKLQGHYSVILPSSRYLASQKGNTSETIVIDDEEDMETNGREKTVSSSFIEWGFPGTKNRTKDLDFSTSSLSRSKTKTAVGPFNPGRMNVAGGEFQNGGFTTHHSPDSWISQSASFPRNQKQPGVDSLSPVASLPKQIFQSSAQQQPTKAAKITCANCKKPLQKGQTAYQRKGSAHLFCSTTCLSSFSHKRTPKKRNVTCKKDAPTKKATVVPQGESSEPFPKCFSTSHLSPYEDSQNLRKRVLNKSRCTICNKLTEIRHEVSVNNVTHKLCSNQCFNKYRLANGLVMNCCEQCGEYLPGKGAGNNVLVIEGQQMRFCCQSCVNEYKQMIETNLKKILASENRKRNAVGEENERELYGSLNILPEKTEEIPEKKEKTSELQVSAECSLDASVVQQNVNLPPSVSDIADKLQEQLGEKPSEDSIIPAVLSADPGTWPRILSIKQRDTLVENDPPQVRNFNFPKDSTGRKFSETYYTRILANGEKTTRSWLLYSTSKDSVFCLYCKLFGEGKNQLKNENGCRDWQHLSHILSKHEESEMHINNSVKYSKLKSDLKTSKIVEASEHRLQEREGKDGVKLLYTLDLI", "length": 673, "header": "sp|A6QPH9-1|ZMYM5_BOVIN Isoform 1 of Zinc finger MYM-type protein 5 OS=Bos taurus OX=9913 GN=ZMYM5 PE=2 SV=2 CANONICAL=A6QPH9-1" }, "locus": { "chromosome": "12", "start_pos": 36260877, "end_pos": 36244019, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009433.6", "url": "https://www.ensembl.org/id/ENSBTAT00000009433.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009433.5", "url": "https://www.ensembl.org/id/ENSBTAP00000009433.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:536389", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536389", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZPX0-1", "protein_name": "Zinc finger MYM-type containing 5", "gene_name": "Zmym5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEAHLEDAESSDGPSSSVGSTARYTPVEDDDVVFVESVQPAVCGPAVSNERNLIFTSSKHENPRGNYSTVPPSSRDLTFHKGNICETIIIDDEGDTETNGGEERNPTNFIEWGPHGNKNSTKTVDFPIASLSRSKTKTAVGPFNPGRIDITDEFHNGRFAVHPNPDSCISQSASFPRNQKQQGADSLSPVASLPKQNFQPSNQHLTKPANKIICANCKNPLQKGQTAYQRKGSAHLFCSTTCLSSFSHKRTRKTRSAMCKKDSPVKPTTIVPPVESSKSLREFHSASPSPYENCQSLRKEVFTKSRCIICNKLGEVRHEISVNSITHKLCSNSCFNEYRLTNGLIMNCCEQCSKYMPKSTGHSILITGQQKRFCCLSCADEYKEIMEAKSKILLLQNRKRNAIREENEKKLYESSKTLSGNTGEIPEKKEKISEIIKVAADCSLDTSSEERNVNLPCSVAAVSDKFQEQLGDKNSEEFDASVVLSLDPGSWPRILNMKQREFLVKTEPPQVRNFNFPKDSIGKKFSETYYTQILPNGEKTTRSWLLYSVSKDSVFCLYCRLFGEGKNQLRNENGCKDWHHLSHILSKHEESEMHINNSVKYSKFKSNLQNKTNEATEGGENIVQLLYI", "length": 628 }, "evidence": [ { "id": "A6QPH9", "url": "https://omabrowser.org/oma/group/A6QPH9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HDG5-1", "protein_name": "Zinc finger MYM-type protein 5", "gene_name": "Zmym5", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAHLTDVDSFGDPASSLVNASRNSPVEDDDVVFVESVQPPVCTPARAEERNFVFASSKHENPQGNYSIIPPSLKDLTSQKGNTYETIVIDDEGDTETNGGDEKNPTNFTEWEPHGNKHSTKNLDFFISSLSRSKTKTGVGPFNPGRMDAADALQNGRFAAHHNPDSWISQSASFPRNQKQQGMDSLSPVASLPKQNFQPSNQYLTKPKITCANCKNPLQKGQTAYQRKGSAHLFCSTTCLSSFSHKRTRKTRNVTCKKDYPMKTATVIPPVESSKSLPELHSASLSSCEYSQSLRKEVFTKSRCIMCNKLGEVRHEISVNNVTHKLCSNNCFNEYRFTNGLIMNCCEQCGKYMPKNTGHRVLITGQQKSFCCQNCATEYKEIMETKSKIALLQNRKRNAVREENERKLHESSTLSEKIGEIPEKKEKVSEVIGVAVQCSQDASREERLVNSPPVTAGPDMVKEQLEDSSEDSEMSGVLPSDPGSWPRILNMKQRDTLVKNNPPQVRNFNFPKDSTGRKFSEAYYTRILPSGEKTTRSWLLYSASKDSVFCLYCRLFGEGKNQLRNENGCKDWQHLSHILSKHEESEMHINNSVKYSKLKSYLENKTSEATEHGLCEVEEDGVLLLYT", "length": 628 }, "evidence": [ { "id": "A6QPH9", "url": "https://omabrowser.org/oma/group/A6QPH9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q3U2E2-1", "protein_name": "Zinc finger MYM-type protein 5", "gene_name": "Zmym5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEAHLADMESSGGPTSSLAGTSRNTHVEDDDVVFIESVQPPICAPAIPNERNFVFASSKHENPPGTDSTISPSWRDLTSQKGNLCETIVIDDEGDTDTNGGEEKNPTDFIEWGPNGNKSSTKNVDFPIASLSRSKTKTAVGPFNPGRIDVTDAFQNGRFAVHHNPDSWISQSASFPRNQKQQGVDSLSPVASLPKQIFQPSNQQPTKPVKVTCANCKKPLQKGQTAYQRKGSAHLFCSTTCLSSFSHKRTRKTRNVMCKKDSPVRTTTIVPPVESSKSLQGFYNASLSPYENCQSLRKEVFTKSRCIICNKLGEVRHEISVNSITHKLCSNNCFNEYRLTNGLIMNCCEQCSKYMPKSTGHSILITGQQKRFCCQNCADEYKEIMEAKSKLLLLQNRKRNAIREENEKRLRESSGTLSGNTGDIPEKKEKSSEIIKVAADCSLDTSSEEQNVNLPCSVAVISDTFKEQLGDKNSEELDMSILPSLDPGSWPRILNMKQREFLVKNNPPQIRNFNFPKDSAGKKFSETYYTRILPNGEKGTRPWLLYSASKDSVFCLYCRLFGEGKNQLRNENGCKDWHHLSHLLSKHDESEMHINNSVKYSKLKSDLENKTNEATEGGEDCVQLLYT", "length": 627 }, "evidence": [ { "id": "A6QPH9", "url": "https://omabrowser.org/oma/group/A6QPH9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UJ78-4", "protein_name": "Zinc finger MYM-type protein 5", "gene_name": "ZMYM5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEKCSVGGLELTEQTPALLGNMAMATSLMDIGDSFGHPACPLVSRSRNSPVEDDDDDDDVVFIESIQPPSISAPAIADQRNFIFASSKNEKPQGNYSVIPPSSRDLASQKGNISETIVIDDEEDIETNGGAEKKSSCFIEWGLPGTKNKTNDLDFSTSSLSRSKTKTGVRPFNPGRMNVAGDLFQNGEFATHHSPDSWISQSASFPSNQKQPGVDSLSPVALLRKQNFQPTAQQQLTKPAKITCANCKKPLQKGQTAYQRKGSAHLFCSTTCLSSFSHKRTQNTRSIICKKDASTKKANVILPVESSKSFQEFYSTSCLSPCENNWNLKKGVFNKSRCTICSKLAEIRHEVSVNNVTHKLCSNHCFNKYRLANGLIMNCCEHCGEYMPSKSTGNNILVIGGQQKRFCCQSCINEYKQMMETKSKKLTASENRKRNAFREENEKQLYGSSNTLLKKIEGIPEKKEKTSQLQLSVECGTDTLLIQENVNLPPSSTSTIADTFQEQLEEKNFEDSIVPVVLSADPGTWPRILNIKQRDTLVENVPPQVRNFNFPKDNTGRKFSETYYTRILPNGEKTTRSWLLYSTSKDSVFCLYCKLFGEGKNQLKNENGCKDWQHLSHILSKHEESEMHVNNSVKYSKLKSDLKKNKAIDAAEHRLYENEKNDGVLLLYT", "length": 669 }, "evidence": [ { "id": "A6QPH9", "url": "https://omabrowser.org/oma/group/A6QPH9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A6QPH9", "url": "https://www.uniprot.org/uniprotkb/A6QPH9" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A6QPH9", "url": "https://www.uniprot.org/uniprotkb/A6QPH9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A6QPH9", "url": "https://www.uniprot.org/uniprotkb/A6QPH9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A6QPH9", "url": "https://www.uniprot.org/uniprotkb/A6QPH9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 149, "end_pos": 151, "annotation": "n_glycosylation_sequon" }, { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" }, { "start_pos": 335, "end_pos": 337, "annotation": "n_glycosylation_sequon" }, { "start_pos": 356, "end_pos": 358, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" }, { "start_pos": 630, "end_pos": 632, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QPH9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 673, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QPH9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QPH9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 149, "end_pos": 151 }, { "start_pos": 287, "end_pos": 289 }, { "start_pos": 335, "end_pos": 337 }, { "start_pos": 356, "end_pos": 358 }, { "start_pos": 44, "end_pos": 46 }, { "start_pos": 630, "end_pos": 632 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QQ85-1", "uniprot_ac": "A6QQ85", "uniprot_id": "UPK3L_BOVIN", "mass": { "chemical_mass": 27346.0, "monoisotopic_mass": 27346.0 }, "refseq": {}, "gene_names": [ { "name": "UPK3BL1", "type": "recommended", "evidence": [ { "id": "A6QQ85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ85" } ] }, { "name": "UPK3BL2", "type": "recommended", "evidence": [ { "id": "A6QQ85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ85" } ] } ], "protein_names": [ { "name": "Uroplakin-3b-like protein 1", "type": "recommended", "evidence": [ { "id": "A6QQ85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ85/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QQ85", "url": "https://www.uniprot.org/uniprotkb/A6QQ85" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UPK3BL1", "url": "https://www.uniprot.org/uniprotkb/A6QQ85", "locus": {} } ], "crossref": [ { "id": "A6QQ85", "url": "https://alphafold.ebi.ac.uk/entry/A6QQ85", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020524", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020524", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09969", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09969", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR024831", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024831", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IYTCYDT", "url": "https://omabrowser.org/oma/group/IYTCYDT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QQ85", "url": "https://www.orthodb.org/?gene=A6QQ85", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15446", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15446", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15446:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15446:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9SM05", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM05-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM05-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQ85", "url": "https://www.uniprot.org/uniprotkb/A6QQ85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQ85-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ85-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLGRGQSPLLMALLLLLACLQMGMSLERISYVPQLSSATLAGRLTQSTFTLEQPRGQFSHPSISDSDAIWLVVAHSNATQKFTAPQKVEDTPVPADFPQRGYYLTLRASRALYPGGPPSNQLRVLRVGNDTRCSPRTRGCNRPLPGPGPYRVKFLVMSDRGPMAETEWSSETRLQQAEVLQAAPGPQTAGTVVIIAILSVLLAVLLAALLALLIFTWYDTCGSTPISGPGELVFVRKYDTHHMSRPSTVGGS", "length": 253, "header": "sp|A6QQ85-1|UPK3L_BOVIN Isoform 1 of Uroplakin-3b-like protein 1 OS=Bos taurus OX=9913 GN=UPK3BL1 PE=2 SV=2 CANONICAL=A6QQ85-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SM05-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ85/entry#A0AAA9SM05-1", "sequence": { "sequence": "MLSFKPTFSLSSFTFIKRLFSSSSLSVIRVVSSPYLSLFSLPPPGPERISYVPQLSSATLAGRLTQSTFTLEQPRGQFSHPSISDSDAIWLVVAHSNATQKFTAPQKVEDTPVPADFPQRGYYLTLRASRALYPGGPPSNQLRVLRVGNDTRCSPRTRGCNRPLPGPGPYRVKFLVMSDRGPMAETEWSSETRLQQAEVLQAAPGPQTAGTVVIIAILSVLLAVLLAALLALLIFTWYDTCGSTPISGPGELVFVRKYDTHHMSRPSTVGGS", "length": 272, "header": "tr|A0AAA9SM05-1|UPK3L_BOVIN Computationally mapped isoform of Uroplakin-3b-like protein 1 OS=Bos taurus OX=9913 GN=UPK3BL1 PE=2 SV=1 CANONICAL=A6QQ85-1" }, "locus": { "chromosome": "25", "start_pos": 34524508, "end_pos": 34521580, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111571.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111571.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083773.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083773.1" } ] } }, { "isoform_ac": "A6QQ85-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ85/entry#A6QQ85-1", "sequence": { "sequence": "MGLGRGQSPLLMALLLLLACLQMGMSLERISYVPQLSSATLAGRLTQSTFTLEQPRGQFSHPSISDSDAIWLVVAHSNATQKFTAPQKVEDTPVPADFPQRGYYLTLRASRALYPGGPPSNQLRVLRVGNDTRCSPRTRGCNRPLPGPGPYRVKFLVMSDRGPMAETEWSSETRLQQAEVLQAAPGPQTAGTVVIIAILSVLLAVLLAALLALLIFTWYDTCGSTPISGPGELVFVRKYDTHHMSRPSTVGGS", "length": 253, "header": "sp|A6QQ85-1|UPK3L_BOVIN Isoform 1 of Uroplakin-3b-like protein 1 OS=Bos taurus OX=9913 GN=UPK3BL1 PE=2 SV=2 CANONICAL=A6QQ85-1" }, "locus": { "chromosome": "25", "start_pos": 34524508, "end_pos": 34519620, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027343.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027343.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027343.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027343.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 130, "start_aa": "Asn", "end_pos": 130, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn130", "evidence": [ { "id": "A6QQ85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ85#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 78, "start_aa": "Asn", "end_pos": 78, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn78", "evidence": [ { "id": "A6QQ85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ85#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AAZ4-1", "protein_name": "Uncharacterized protein", "gene_name": "UPK3BL", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRPLLLLLLATAHGLDKLSYKPTLVGGNVEGRMTGSTFVLEQPRCVFDSYSTANIWLVVATREGMDAFNDSAQPGMPEWSFQRFPTNTSAYLTLGAMQYHYGCPKPDRELTVLRVGSETDCADNISVPNCNGPLPGPGPYWVKFLALNGSEPTATTEWSGPITLKTAREPQSIPGTGGARSGAMIAITAILSVLLAILLAALLATLCSSEACGVGSFRPDAASIRRYNTHHVYDQPAARL", "length": 240 }, "evidence": [ { "id": "A6QQ85", "url": "https://omabrowser.org/oma/group/A6QQ85/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A2CE76-1", "protein_name": "Uroplakin-3b precursor", "gene_name": "upk3b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNTHNAIRLVSLLSIWMLAAQGQIFQPQLAPANFLGRITSNTVILQQPYCVFTQTCPGCEIWLVAALSTGTGNFNALVNISSPISLSVSPYPTAFLPSSAQFFLTRVGPLANFPCNTAPAFPYFTVGADGICTGINCNGVLPVGSIVSFRYLLIDPSNYTVVNMTNWGGPFNLTTLLSYQTINDGLSARSGAMVVITTLLCVAVALLLLVFFIMLCVSCCGKKDGKTVTVMSSIRIPRYDTHNLKEHVHPYDNQAYEPDAKNYSRSQTLPKSPVRK", "length": 276 }, "evidence": [ { "id": "A6QQ85", "url": "https://omabrowser.org/oma/group/A6QQ85/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "B0FP48-1", "protein_name": "Uroplakin-3b-like protein 1", "gene_name": "UPK3BL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDNSWRLGPAIGLSAGQSQLLVSLLLLLTRVQPGTDVAAPEHISYVPQLSNDTLAGRLTLSTFTLEQPLGQFSSHNISDLDTIWLVVALSNATQSFTAPRTNQDIPAPANFSQRGYYLTLRANRVLYQTRGQLHVLRVGNDTHCQPTKIGCNHPLPGPGPYRVKFLVMNDEGPVAETKWSSDTRLQQAQALRAVPGPQSPGTVVIIAILSILLAVLLTVLLAVLIYTCFNSCRSTSLSGPEEAGSVRRYTTHLAFSTPAEGAS", "length": 263 }, "evidence": [ { "id": "A6QQ85", "url": "https://omabrowser.org/oma/group/A6QQ85/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "D3ZXT5-1", "protein_name": "Uroplakin 3B like 1", "gene_name": "Upk3bl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGPHRKQSMLLLPLLVLVTCVQPGTGLESINYVPQLPSATLEGRLTQSTFTLEQPLDQFKNVNLSDADPIWLVVARSDMPPPAAQNFTAPRKVEDRHAPAHFDDNGYYLTLRASRVHYKGSQNDSRLPVLRVGNDNNCSVRSQGCNSPLPGPGPYRVKFLAMNAKGPVAETLWSKDIYLQQAQTFRGAPGSQSKGTVVIIAFSSILLAILLAVFLMLVISACCSSTSVSSPEEQVRMRRYHTHHVGSLPAERSS", "length": 254 }, "evidence": [ { "id": "A6QQ85", "url": "https://omabrowser.org/oma/group/A6QQ85/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D701-1", "protein_name": "Uroplakin-3b-like protein 1", "gene_name": "Upk3bl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGPHGKQSVLRMPLLLLLTCVQSGTGLESINYAPQLLGATLEGRLTQSTFTLEQPLGQFKNVNLSDPDPIWLVVAHSNAAQNFTAPRKVEDRHAPANFDRNGYYLTLRANRVHYKGGQPDSQLRVLRVGNDNNCSLESQGCNSPLPGAGPYRVKFLAMSAEGPVAETLWSEEIYLQQAQTFREAPGSQGKGTVVIIAFLSILLAILLVVFLVLVISACLSTSGSSPEEQVRMRHYHTHHMGSLRAERSS", "length": 249 }, "evidence": [ { "id": "A6QQ85", "url": "https://omabrowser.org/oma/group/A6QQ85/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A6QQ85", "url": "https://www.uniprot.org/uniprotkb/A6QQ85" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 78, "end_pos": 80, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QQ85-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 253, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QQ85-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QQ85" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 78, 130 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 130, "end_pos": 132 }, { "start_pos": 78, "end_pos": 80 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QNX3-1", "uniprot_ac": "A6QNX3", "uniprot_id": "NXT2_BOVIN", "mass": { "chemical_mass": 16313.0, "monoisotopic_mass": 16313.0 }, "refseq": { "ac": "NP_001093823", "name": "NTF2-related export protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093823" }, "gene_names": [ { "name": "NXT2", "type": "recommended", "evidence": [ { "id": "A6QNX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNX3" } ] }, { "name": "NXT2", "type": "synonym", "evidence": [ { "id": "NP_001093823", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093823" } ] } ], "protein_names": [ { "name": "NTF2-related export protein 2", "type": "recommended", "evidence": [ { "id": "A6QNX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNX3/entry#names_and_taxonomy" } ] }, { "name": "NTF2-related export protein 2", "type": "synonym", "evidence": [ { "id": "NP_001093823", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093823" } ] } ], "function": [ { "annotation": "Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SP61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP61#function" }, { "database": "UniProtKB", "id": "RU369002", "url": "https://www.uniprot.org/uniprotkb/RU369002#function" }, { "database": "UniProtKB", "id": "A0AAA9SQP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQP9#function" } ] }, { "annotation": "Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A6QNX3", "url": "https://www.uniprot.org/uniprotkb/A6QNX3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QNX3", "url": "https://www.uniprot.org/uniprotkb/A6QNX3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NXT2", "url": "https://www.uniprot.org/uniprotkb/A6QNX3", "locus": { "chromosome": "X", "start_pos": 57957664, "end_pos": 57951089, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020739", "url": "https://www.ensembl.org/id/ENSBTAG00000020739" } ] } } ], "crossref": [ { "id": "A6QNX3", "url": "https://alphafold.ebi.ac.uk/entry/A6QNX3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020739", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020739", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00780", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00780", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513043", "url": "https://www.ncbi.nlm.nih.gov/gene/513043", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002075", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002075", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513043", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513043", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HFTRLYY", "url": "https://omabrowser.org/oma/group/HFTRLYY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QNX3", "url": "https://www.orthodb.org/?gene=A6QNX3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12612", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12612", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02136", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02136", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001093823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093823", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SP61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP61-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQP9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QNX3", "url": "https://www.uniprot.org/uniprotkb/A6QNX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QNX3-1", "url": "https://www.uniprot.org/uniprotkb/A6QNX3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAMAVEFKTYVDQACRAAEEFVNIYYETMDKRRRALTRLYLDKATLIWNGNVVTGLEALANFFDMLPSSEFQVNMLDCQPVHEQATQSQTTVLVVTSGTVKFDGNKQHYFNQNFLLTAQTTANNTVWKIASDCFRFQDWATI", "length": 142, "header": "sp|A6QNX3-1|NXT2_BOVIN Isoform 1 of NTF2-related export protein 2 OS=Bos taurus OX=9913 GN=NXT2 PE=2 SV=1 CANONICAL=A6QNX3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SP61-1", "url": "https://www.uniprot.org/uniprotkb/A6QNX3/entry#A0AAA9SP61-1", "sequence": { "sequence": "MLGLLLMEFKTYVDQACRAAEEFVNIYYETMDKRRRALTRLYLDKATLIWNGNVVTGLEALANFFDMLPSSEFQVNMLDCQPVHEQATQSQTTVLVVTSGTVKFDGNKQHYFNQNFLLTAQTTANNTVWKIASDCFRFQDWATI", "length": 144, "header": "tr|A0AAA9SP61-1|NXT2_BOVIN Computationally mapped isoform of NTF2-related export protein 2 OS=Bos taurus OX=9913 GN=NXT2 PE=2 SV=1 CANONICAL=A6QNX3-1" }, "locus": { "chromosome": "X", "start_pos": 57955638, "end_pos": 57951794, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118041.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118041.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087157.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087157.1" } ] } }, { "isoform_ac": "A0AAA9SQP9-1", "url": "https://www.uniprot.org/uniprotkb/A6QNX3/entry#A0AAA9SQP9-1", "sequence": { "sequence": "YSMAIREFKTYVDQACRAAEEFVNIYYETMDKRRRALTRLYLDKATLIWNGNVVTGLEALANFFDMLPSSEFQVNMLDCQPVHEQATQSQTTVLVVTSGTVKFDGNKQHYFNQNFLLTAQTTANNTVWKIASDCFRFQDWATI", "length": 143, "header": "tr|A0AAA9SQP9-1|NXT2_BOVIN Computationally mapped isoform of NTF2-related export protein 2 OS=Bos taurus OX=9913 GN=NXT2 PE=2 SV=1 CANONICAL=A6QNX3-1" }, "locus": { "chromosome": "X", "start_pos": 57955638, "end_pos": 57952187, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101083.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101083.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088664.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088664.1" } ] } }, { "isoform_ac": "A6QNX3-1", "url": "https://www.uniprot.org/uniprotkb/A6QNX3/entry#A6QNX3-1", "sequence": { "sequence": "MAMAVEFKTYVDQACRAAEEFVNIYYETMDKRRRALTRLYLDKATLIWNGNVVTGLEALANFFDMLPSSEFQVNMLDCQPVHEQATQSQTTVLVVTSGTVKFDGNKQHYFNQNFLLTAQTTANNTVWKIASDCFRFQDWATI", "length": 142, "header": "sp|A6QNX3-1|NXT2_BOVIN Isoform 1 of NTF2-related export protein 2 OS=Bos taurus OX=9913 GN=NXT2 PE=2 SV=1 CANONICAL=A6QNX3-1" }, "locus": { "chromosome": "X", "start_pos": 57955638, "end_pos": 57951239, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027635.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027635.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027635.5", "url": "https://www.ensembl.org/id/ENSBTAP00000027635.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513043", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513043", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B2GV77-1", "protein_name": "NTF2-related export protein 2", "gene_name": "Nxt2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAMAVDFKMYVDQACRAAEEFVNIYYETMDKRRHALVRLYLDKATLIWNGNVVTGLEALANFFEMLPSSEFQINMLDCQPVHEQATQYQTTVLVVTSGVVKFDGNKQHFFNQNFLLTAQSTPNSTVWKIASDCFRFQDWASI", "length": 142 }, "evidence": [ { "id": "A6QNX3", "url": "https://omabrowser.org/oma/group/A6QNX3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9QCN6-1", "protein_name": "NTF2-related export protein", "gene_name": "nxt2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSLTVDFRTQVDQSCRYSEEFINIYYECMDKKRRNLKRLYLDKATLVWNGNAVTGQEALGEFFESLPSSEFQVQTLDCQPVHEQATQGQTTLLVVAAGSVKFEGNKQRFFNQNFLLTAQASPNSDQPVWKIASDCFRFQDWAN", "length": 143 }, "evidence": [ { "id": "A6QNX3", "url": "https://omabrowser.org/oma/group/A6QNX3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "K7GNP4-1", "protein_name": "NTF2-related export protein", "gene_name": "NXT2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAMSVDFKTYVDQACRAAEEFVNIYYETMDKRRRALTRLYLDKATLIWNGNVVTGLEALTNFFEMLPSSEFQVNMLDCQPVHEQATQAQTTVLVVTSGTVKFDGNKQHYFNQNFLLTAQSTPNNTVWKIASDCFRFQDWASS", "length": 142 }, "evidence": [ { "id": "A6QNX3", "url": "https://omabrowser.org/oma/group/A6QNX3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3UNA4-1", "protein_name": "NTF2-related export protein 2", "gene_name": "Nxt2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALAVNFKTYVDQACRAAEEFVNIYYETMDKRRHALVRLYLDKATLIWNGNVVTGLEALANFFEMLPSSEFQINMLDCQPVHEQATQCQTTVLVVTSGVVKFDGNKQHFFNQNFLLTAQSTPNSTVWKIASDCFRFQDWASI", "length": 142 }, "evidence": [ { "id": "A6QNX3", "url": "https://omabrowser.org/oma/group/A6QNX3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54U15-1", "protein_name": "NTF2 domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSFRKNTFNNNPNYNNNNNNNNHNDNSPTNGNVDAKLKKIVETITPRAEVFIKEFYYPKYDSSRADLIGLYKDHSVSIWNGTECKGPEHIGKLLAEIPNSVHVVETFDAQPVPSDDKENPNILITATGKVTYKTTSQHQFHQTFLLVKDPTNSNLFYLSYDCIRLIS", "length": 167 }, "evidence": [ { "id": "A6QNX3", "url": "https://omabrowser.org/oma/group/A6QNX3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5ZLH0-1", "protein_name": "NTF2-related export protein 2", "gene_name": "NXT2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAASVDFKTYVDQACRAAEEFVNIYYETMDKRRRALTRLYLDKATLIWNGNAVSGQEALNEFFEMLPSSEFQVNVLDCQPVHEQATQSQTTVLVVTCGTVKFDGNKQRYFNQNFLLTAQATSNSTVWKIASDCFRFQDWAN", "length": 141 }, "evidence": [ { "id": "A6QNX3", "url": "https://omabrowser.org/oma/group/A6QNX3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9NPJ8-1", "protein_name": "NTF2-related export protein 2", "gene_name": "NXT2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATSLDFKTYVDQACRAAEEFVNIYYETMDKRRRALTRLYLDKATLIWNGNAVSGLDALNNFFDTLPSSEFQVNMLDCQPVHEQATQSQTTVLVVTSGTVKFDGNKQHFFNQNFLLTAQSTPNNTVWKIASDCFRFQDWSSS", "length": 142 }, "evidence": [ { "id": "A6QNX3", "url": "https://omabrowser.org/oma/group/A6QNX3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9V3H8-1", "protein_name": "NTF2-related export protein", "gene_name": "Nxt1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDSDLKAKVESCARTADTFTRLYYASVDNRRQQIGRLYLDNATLSWNGNGAIGRQMIESYFQELPSSNHQLNTLDAQPIVDQAVSNQLAYLIMASGSVKFADQQLRKFQQTFIVTAENDKWKVVSDCYRMQEV", "length": 133 }, "evidence": [ { "id": "A6QNX3", "url": "https://omabrowser.org/oma/group/A6QNX3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "poly(A)+ mRNA export from nucleus", "id": "GO:0016973", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016973", "evidence": [ { "database": "UniProtKB", "id": "A6QNX3", "url": "https://www.uniprot.org/uniprotkb/A6QNX3" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A6QNX3", "url": "https://www.uniprot.org/uniprotkb/A6QNX3" } ], "pmid": "" }, { "name": "nucleocytoplasmic transport", "id": "GO:0006913", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006913", "evidence": [ { "database": "UniProtKB", "id": "A6QNX3", "url": "https://www.uniprot.org/uniprotkb/A6QNX3" } ], "pmid": "" }, { "name": "mRNA transport", "id": "GO:0051028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051028", "evidence": [ { "database": "UniProtKB", "id": "A6QNX3", "url": "https://www.uniprot.org/uniprotkb/A6QNX3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A6QNX3", "url": "https://www.uniprot.org/uniprotkb/A6QNX3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A6QNX3", "url": "https://www.uniprot.org/uniprotkb/A6QNX3" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A6QNX3", "url": "https://www.uniprot.org/uniprotkb/A6QNX3" } ], "pmid": "" }, { "name": "nuclear pore central transport channel", "id": "GO:0044613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044613", "evidence": [ { "database": "UniProtKB", "id": "A6QNX3", "url": "https://www.uniprot.org/uniprotkb/A6QNX3" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A6QNX3", "url": "https://www.uniprot.org/uniprotkb/A6QNX3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A6QNX3", "url": "https://www.uniprot.org/uniprotkb/A6QNX3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QNX3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 142, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QNX3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QNX3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A6QNX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNX3" }, { "id": "PRU00137", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00137" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NTF2", "eco_id": "ECO_0000255", "start_pos": 17, "end_pos": 136, "start_aa": "Ala", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 123, "end_pos": 125 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QQ60-1", "uniprot_ac": "A6QQ60", "uniprot_id": "STPG1_BOVIN", "mass": { "chemical_mass": 37104.0, "monoisotopic_mass": 37104.0 }, "refseq": { "ac": "NP_001095774", "name": "O(6)-methylguanine-induced apoptosis 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095774" }, "gene_names": [ { "name": "STPG1", "type": "recommended", "evidence": [ { "id": "A6QQ60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ60" } ] }, { "name": "C1orf201", "type": "synonym", "evidence": [ { "id": "NP_001095774", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095774" } ] }, { "name": "C2H1orf201", "type": "synonym", "evidence": [ { "id": "NP_001095774", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095774" } ] }, { "name": "MAPO2", "type": "synonym", "evidence": [ { "id": "NP_001095774", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095774" } ] }, { "name": "STPG1", "type": "synonym", "evidence": [ { "id": "NP_001095774", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095774" } ] } ], "protein_names": [ { "name": "O(6)-methylguanine-induced apoptosis 2", "type": "recommended", "evidence": [ { "id": "A6QQ60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ60/entry#names_and_taxonomy" } ] }, { "name": "MAPO2", "type": "synonym", "evidence": [ { "id": "A6QQ60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ60/entry#names_and_taxonomy" } ] }, { "name": "O(6)-methylguanine-induced apoptosis 2", "type": "synonym", "evidence": [ { "id": "NP_001095774", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095774" } ] }, { "name": "Sperm-tail PG-rich repeat-containing protein 1", "type": "synonym", "evidence": [ { "id": "A6QQ60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ60/entry#names_and_taxonomy" } ] }, { "name": "UPF0490 protein C1orf201 homolog", "type": "synonym", "evidence": [ { "id": "NP_001095774", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095774" } ] }, { "name": "sperm-tail PG-rich repeat-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001095774", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095774" } ] } ], "function": [ { "annotation": "May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine.", "evidence": [ { "database": "UniProtKB", "id": "A6QQ60", "url": "https://www.uniprot.org/uniprotkb/A6QQ60#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QQ60", "url": "https://www.uniprot.org/uniprotkb/A6QQ60" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STPG1", "url": "https://www.uniprot.org/uniprotkb/A6QQ60", "locus": { "chromosome": "2", "start_pos": 128597214, "end_pos": 128500788, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010278", "url": "https://www.ensembl.org/id/ENSBTAG00000010278" } ] } } ], "crossref": [ { "id": "A6QQ60", "url": "https://alphafold.ebi.ac.uk/entry/A6QQ60", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010278", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010278", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616738", "url": "https://www.ncbi.nlm.nih.gov/gene/616738", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010736", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010736", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616738", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616738", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GQYENPI", "url": "https://omabrowser.org/oma/group/GQYENPI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QQ60", "url": "https://www.orthodb.org/?gene=A6QQ60", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35678", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35678", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35678:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35678:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07004", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07004", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095774", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095774", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SPS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPS8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ABI5", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABI5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7ABI5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABI5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQ60", "url": "https://www.uniprot.org/uniprotkb/A6QQ60", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQ60-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ60-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDNSTQKDQHSGKKYSRKANKVQKGFTAAYPTQSSIPYKYQPLIIPESEKKGFNSQAKRFYHKQDDIPGPGFYNVIHQSPVFDSVSLSKKGTCTFPSMCARLDTIVSKFPAANAYTIPSRLVSKKDFSNSCSSMFQLPSYEKVLKFETPAPNQYNASDSCCKQANNVCARAGFVSKTQRGLFTVSKTGPAPGHYDVNESLVKQSPKILMSCFKSKTDRGLKLTSTGPGPGYYNPNGHPKVQKKTLIPRNPILNFSAQPLPLPPKPPLPGPGQYEIVDYTGPRKHFISSASFVSNTRRWTAGPSQPGMPGPATYRPEFPGKQSFLYNEDNKWIPVL", "length": 335, "header": "sp|A6QQ60-1|STPG1_BOVIN Isoform 1 of O(6)-methylguanine-induced apoptosis 2 OS=Bos taurus OX=9913 GN=STPG1 PE=2 SV=1 CANONICAL=A6QQ60-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPS8-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ60/entry#A0AAA9SPS8-1", "sequence": { "sequence": "MDNSTQKDQHSGKKYSRKANKVQKGFTAAYPTQSSIPYKYQPLIIPESEKKGFNSQAKRFYHKQDDIPGPGFYNVIHQSPVFDSVSLSKKGTCTFPSMCARLDTIVSKFPAANAYTIPSRLVSKKDFSNSCSSMFQLPSYEKVLKFETPAPNQYNASDSCCKQANNVCARAGFVSKTQRGLFTVSKTGPAPGHYDVNESLVKQSPKILMSCFKSKTDRGLKLTSTGPGPGYYNPNGHPKVQKKTLIPSPTGQDGYTEFTEDADSLRRWNREARKCPLLRRHKRRGFDPFGKIPWSRKWQPTPVFLSGKSHGQRSLEGYR", "length": 319, "header": "tr|A0AAA9SPS8-1|STPG1_BOVIN Computationally mapped isoform of O(6)-methylguanine-induced apoptosis 2 OS=Bos taurus OX=9913 GN=STPG1 PE=2 SV=1 CANONICAL=A6QQ60-1" }, "locus": { "chromosome": "2", "start_pos": 128552369, "end_pos": 128508356, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090036.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090036.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087373.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087373.1" } ] } }, { "isoform_ac": "A0AAF7ABI5-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ60/entry#A0AAF7ABI5-1", "sequence": { "sequence": "TNTLAKNIPERLTKSRKDDIPGPGFYNVIHQSPVFDSVSLSKKGTCTFPSMCARLDTIVSKFPAANAYTIPSRLVSKKDFSNSCSSMFQLPSYEKVLKFETPAPNQYNASDSCCKQANNVCARAGFVSKTQRGLFTVSKTGPAPGHYDVNESLVKQSPKILMSCFKSKTDRGLKLTSTGPGPGYYNPNGHPKVQKKTLIPRNPILNFSAQPLPLPPKPPLPGPGQYEIVDYTGPRKHFISSASFVSNTRRWTAGPSQPGMPGPATYRPEFPGKQSFLYNEDNKWIPVL", "length": 288, "header": "tr|A0AAF7ABI5-1|STPG1_BOVIN Computationally mapped isoform of O(6)-methylguanine-induced apoptosis 2 OS=Bos taurus OX=9913 GN=STPG1 PE=2 SV=1 CANONICAL=A6QQ60-1" }, "locus": { "chromosome": "2", "start_pos": 128559160, "end_pos": 128508378, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073643.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073643.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066283.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066283.2" } ] } }, { "isoform_ac": "A6QQ60-1", "url": "https://www.uniprot.org/uniprotkb/A6QQ60/entry#A6QQ60-1", "sequence": { "sequence": "MDNSTQKDQHSGKKYSRKANKVQKGFTAAYPTQSSIPYKYQPLIIPESEKKGFNSQAKRFYHKQDDIPGPGFYNVIHQSPVFDSVSLSKKGTCTFPSMCARLDTIVSKFPAANAYTIPSRLVSKKDFSNSCSSMFQLPSYEKVLKFETPAPNQYNASDSCCKQANNVCARAGFVSKTQRGLFTVSKTGPAPGHYDVNESLVKQSPKILMSCFKSKTDRGLKLTSTGPGPGYYNPNGHPKVQKKTLIPRNPILNFSAQPLPLPPKPPLPGPGQYEIVDYTGPRKHFISSASFVSNTRRWTAGPSQPGMPGPATYRPEFPGKQSFLYNEDNKWIPVL", "length": 335, "header": "sp|A6QQ60-1|STPG1_BOVIN Isoform 1 of O(6)-methylguanine-induced apoptosis 2 OS=Bos taurus OX=9913 GN=STPG1 PE=2 SV=1 CANONICAL=A6QQ60-1" }, "locus": { "chromosome": "2", "start_pos": 128559160, "end_pos": 128508356, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013576.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013576.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013576.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013576.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 73, "end_pos": 73, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "A6QQ60", "url": "https://www.uniprot.org/uniprotkb/A6QQ60" } ], "site_lbl": "Tyr73" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616738", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616738", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A5WUY6-1", "protein_name": "O(6)-methylguanine-induced apoptosis 2", "gene_name": "stpg1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGKLHRGLAEFNGCASSIPPKYQTVIISNEEKKGFSSQSRRFEEYLNESPGPGSYLSHSPAEGCSPSFSKRGTGSFASKGGRVPRSFQRLSPGPDAYNLQMSLLHKHDFNRGESRIFRLPYALKKEKPNNENPAPNQYDVSYRAVDKNSTISGESAFRSKTRRSAVVSDKFKGPSPCHYKVSDVLVQKSPQALVSCFKSKTARIQSPVRNNIPGPGTYNPHQPPEPVKRTVLPRRYYLGLSAPPLIPEKVPPFPGPGHYDIVNYNRPVKHMVSSAAFLSGTNRHMQEVKGQDIPGPGFYEPTVLSKTSFLYNPAKLWIPA", "length": 320 }, "evidence": [ { "id": "A6QQ60", "url": "https://omabrowser.org/oma/group/A6QQ60/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1STV8-1", "protein_name": "Sperm tail PG-rich repeat containing 1", "gene_name": "STPG1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDNSTQKDQHSGKKCSRKAKRVQKGFTAAYPTQSSIPYKYQPSVIPESEKKGFNSQAKRFYHKKDDIPGPGFYDVIHQSPVFDSVSLSKKGTGTFPSMRARLDTIISKHPAANAYTIPSHFVSKKDFSNSCSSMFQLPSFRKVLKLETPAPNHYNTSVSCCKQTNNVCARAGFMSKTQRGLFMITETGPAPGHYNVNESLVKQSPKILMSCFKSKTGRGLKLTSTGPGPGYYNPNDHTKVPKKTLIPRNPILNFSAQPLPLPPKPPLPGPGQYEIVDYTGPPKHFISSASFVSNTSRWTAAPAQPGLPGPATYKPELPGKQSFLYNEDNKWIPVL", "length": 335 }, "evidence": [ { "id": "A6QQ60", "url": "https://omabrowser.org/oma/group/A6QQ60/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q4KLY8-1", "protein_name": "O(6)-methylguanine-induced apoptosis 2", "gene_name": "Stpg1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSQKFANTGSFIEREDLGKPNKGVDRVQKGFTAAYPTQSSIPYRHRRSVIPESEKRGFNSQARRFYSKKDDIPGPGFYNVIHQSLVFNSVSLSKRGTCTFPSTCARLGPIISKYPAANAYTIRSELASKKDFSNSCSSMFQLPTFIKVVKSETPAPNHYNASISICKQRNNVCARAGFLSKTPRGFVPSSEPGGPAPGHYDVNESLVRESPKVLVSCFKSKTGRGLKPTSTGPGPGYYNPNDQTKILRKSHLPKTTLLNFSAQPLPLPEKPPLPGPGQYEIVNYQGPPKHFISTASFVSNTSRWPVKSSKPTLPGPASYKPEIPGKQSFLYNEDNKWIPAV", "length": 341 }, "evidence": [ { "id": "A6QQ60", "url": "https://omabrowser.org/oma/group/A6QQ60/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5TH74-1", "protein_name": "O(6)-methylguanine-induced apoptosis 2", "gene_name": "STPG1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDNSAQKNERTGKHPRRASEVQKGFTAAYPTQSSIPFKSQASVIPESEKKGFNSQAKRFPHKKNDIPGPGFYNVIHQSPVSNSVSLSKKGTCMFPSMCARLDTIISKYPAANAYTIPSDFISKRDFSNSCSSMFQLPSFMKALKFETPAPNYYNASVSCCKQRNNVCTRAGFMSKTQRGSFAFADKGPPPGHYDINESLVKQSPNTLMSCFKSKTNRGLKLTSTGPGPGYYNPSDCTKVPKKTLFPKNPILNFSAQPSPLPPKPPFPGPGQYEIVDYLGPRKHFISSASFVSNTSRWTAAPPQPGLPGPATYKPELPGKQSFLYNEDKKWIPVL", "length": 334 }, "evidence": [ { "id": "A6QQ60", "url": "https://omabrowser.org/oma/group/A6QQ60/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D2F5-1", "protein_name": "O(6)-methylguanine-induced apoptosis 2", "gene_name": "Stpg1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSQKFANLDNVVLRADLDKPKKHADRVQKGFTAAYPTQSSIPYRHRTSIIPESEKKGFNSQARRFYSKKDDVPGPGFYNVIHQSPVFSSASLSKRGTCTFPSTCARLGPIISKNPAANAYTIRSDLASKKDFSNSCSSMFQLPSFMKVEKSETPAPNHYNASIASCRQKNNVCARAGFLSKTPRGFIPSSASGGPAPGHYNVNESLVRQSPKFLMSCFKSRTGRGLKPTSIGPGPGYYNPNDQTKILKKSYFPKTTLLNFSAHPLPLPPKPPLPGPGQYEIVNYEGPPKHFISSASFVSNTSRWPMKSSKPNLPGPATYKPEIPGKQSFLYNEDNKWVPAV", "length": 341 }, "evidence": [ { "id": "A6QQ60", "url": "https://omabrowser.org/oma/group/A6QQ60/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A6QQ60", "url": "https://www.uniprot.org/uniprotkb/A6QQ60" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A6QQ60", "url": "https://www.uniprot.org/uniprotkb/A6QQ60" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A6QQ60", "url": "https://www.uniprot.org/uniprotkb/A6QQ60" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "A6QQ60", "url": "https://www.uniprot.org/uniprotkb/A6QQ60" } ], "pmid": "" }, { "name": "positive regulation of mitochondrial membrane permeability involved in apoptotic process", "id": "GO:1902110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902110", "evidence": [ { "database": "UniProtKB", "id": "A6QQ60", "url": "https://www.uniprot.org/uniprotkb/A6QQ60" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 197, "end_pos": 199, "annotation": "n_glycosylation_sequon" }, { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QQ60-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 335, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QQ60-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QQ60" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 73 ], "sequon_annotation_sites": [ { "start_pos": 155, "end_pos": 157 }, { "start_pos": 197, "end_pos": 199 }, { "start_pos": 253, "end_pos": 255 }, { "start_pos": 3, "end_pos": 5 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", 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0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QQM8-1", "uniprot_ac": "A6QQM8", "uniprot_id": "CCD42_BOVIN", "mass": { "chemical_mass": 37872.0, "monoisotopic_mass": 37872.0 }, "refseq": { "ac": "NP_001094636", "name": "coiled-coil domain-containing protein 42", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094636" }, "gene_names": [ { "name": "CCDC42", "type": "recommended", "evidence": [ { "id": "A6QQM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQM8" } ] }, { "name": "CCDC42", "type": "synonym", "evidence": [ { "id": "NP_001094636", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094636" } ] } ], "protein_names": [ { "name": "Coiled-coil domain-containing protein 42", "type": "recommended", "evidence": [ { "id": "A6QQM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQM8/entry#names_and_taxonomy" } ] }, { "name": "Coiled-coil domain-containing protein 42A", "type": "synonym", "evidence": [ { "id": "NP_001094636", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094636" } ] }, { "name": "coiled-coil domain-containing protein 42", "type": "synonym", "evidence": [ { "id": "NP_001094636", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094636" } ] } ], "function": [ { "annotation": "Essential for male fertility. Required for sperm development.", "evidence": [ { "database": "UniProtKB", "id": "A6QQM8", "url": "https://www.uniprot.org/uniprotkb/A6QQM8#function" }, { "database": "UniProtKB", "id": "Q5SV66", "url": "https://www.uniprot.org/uniprotkb/Q5SV66#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QQM8", "url": "https://www.uniprot.org/uniprotkb/A6QQM8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC42", "url": "https://www.uniprot.org/uniprotkb/A6QQM8", "locus": { "chromosome": "19", "start_pos": 28254549, "end_pos": 28267354, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018416", "url": "https://www.ensembl.org/id/ENSBTAG00000018416" } ] } } ], "crossref": [ { "id": "A6QQM8", "url": "https://alphafold.ebi.ac.uk/entry/A6QQM8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018416", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018416", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "536427", "url": "https://www.ncbi.nlm.nih.gov/gene/536427", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR025252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051147", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051147", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536427", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536427", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CADKKRV", "url": "https://omabrowser.org/oma/group/CADKKRV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QQM8", "url": "https://www.orthodb.org/?gene=A6QQM8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21683", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21683", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21683:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21683:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13863", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13863", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001094636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094636", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SRH0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRH0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRH0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQM8", "url": "https://www.uniprot.org/uniprotkb/A6QQM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQM8-1", "url": "https://www.uniprot.org/uniprotkb/A6QQM8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLGIMEEEDLAEYFRLQYGERLLQLLQKFPSIEDQSDSPSVRLLEKKKEAKIMHHAMEQKKETFQRRMETLNLRWEELGIKEAQLKAHIQKFEQFIQENDQKRIRALKKANKERELKRQRMRELAKAKQEMAVLRLEHQRLSAKLQEYSIFNKYLEKVVENSEFEEIHEVIARYKTLVSMHHDLMQSAQEGQEKIERAKARLARYKEEKDDEILQHNNELARLQMRFDRARSDVIIWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKQLKEATFVSLEDTHKQLDMIQQFIQDLSDIWAEVKKKELQQIRV", "length": 316, "header": "sp|A6QQM8-1|CCD42_BOVIN Isoform 1 of Coiled-coil domain-containing protein 42 OS=Bos taurus OX=9913 GN=CCDC42 PE=2 SV=1 CANONICAL=A6QQM8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRH0-1", "url": "https://www.uniprot.org/uniprotkb/A6QQM8/entry#A0AAA9SRH0-1", "sequence": { "sequence": "MSLGIMEEEDLAEYFRLQYGERLLQLLQKFPSIEDQSDSPSVRLLEKKKEAKIMHHAMEQKKETFQRRMETLNLRWEELGIKEAQLKAHIQKFEQFIQENDQKRIRALKKANKERELKRQRMRELAKAKQEMAVLRLEHQRLSAKLQEYSIFNKYLEKVVENSEESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKQLKEATFVSLEDTHKQLDMIQQFIQDLSDIWAEVKKKELQQIRV", "length": 242, "header": "tr|A0AAA9SRH0-1|CCD42_BOVIN Computationally mapped isoform of Coiled-coil domain-containing protein 42 OS=Bos taurus OX=9913 GN=CCDC42 PE=2 SV=1 CANONICAL=A6QQM8-1" }, "locus": { "chromosome": "19", "start_pos": 28267145, "end_pos": 28254756, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128887.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128887.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088944.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088944.1" } ] } }, { "isoform_ac": "A6QQM8-1", "url": "https://www.uniprot.org/uniprotkb/A6QQM8/entry#A6QQM8-1", "sequence": { "sequence": "MSLGIMEEEDLAEYFRLQYGERLLQLLQKFPSIEDQSDSPSVRLLEKKKEAKIMHHAMEQKKETFQRRMETLNLRWEELGIKEAQLKAHIQKFEQFIQENDQKRIRALKKANKERELKRQRMRELAKAKQEMAVLRLEHQRLSAKLQEYSIFNKYLEKVVENSEFEEIHEVIARYKTLVSMHHDLMQSAQEGQEKIERAKARLARYKEEKDDEILQHNNELARLQMRFDRARSDVIIWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKQLKEATFVSLEDTHKQLDMIQQFIQDLSDIWAEVKKKELQQIRV", "length": 316, "header": "sp|A6QQM8-1|CCD42_BOVIN Isoform 1 of Coiled-coil domain-containing protein 42 OS=Bos taurus OX=9913 GN=CCDC42 PE=2 SV=1 CANONICAL=A6QQM8-1" }, "locus": { "chromosome": "19", "start_pos": 28267145, "end_pos": 28254756, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024503.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024503.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024503.4", "url": "https://www.ensembl.org/id/ENSBTAP00000024503.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:536427", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536427", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZAZ8-1", "protein_name": "Coiled-coil domain containing 42", "gene_name": "Ccdc42", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLGMMEEEDLAEYFRLQYGERLLQLLQKFPNVEEQSDSPSIRLLEKKKEAKVMQEAMEHKKETFQRRMETLNLRWEELGIKEEQLKAHIQKFEQFIQENDQKRIRALKKANKERELKRQRLRELAKAKQEMTALRLEHQKLSVKLQDYAIFNKYLEKVVENSEFEEIHEVIARYKTLVSMHHDLMQSAQEGQEKIEHAKARLARYMEEKDDEILQHNNELARLQMRFDRARSDVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKQLKESTQVSLEDTHKQLDMIQQFIQDLSDIWTEVKKKEQLQIRV", "length": 316 }, "evidence": [ { "id": "A6QQM8", "url": "https://omabrowser.org/oma/group/A6QQM8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SSA4-1", "protein_name": "Coiled-coil domain containing 42", "gene_name": "CCDC42", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLGIMEEEDLAEYFRLQYGERLLQLLQKFPSIEDESDSPSVRLLEKKKEAKIMHHAMEQKKETFQRRMETLNLRWEELGVKEAQLKAHIQKFEQFIQENDQKRIRALKKANKERELKRQRMRELAKAKQEMAALRLEHQRLSARLQEYSIFNKFLEKVVENSEFEEIHEVIARYKTLVSMHHDLMQAAQEGQEKIERAKARLARYKEEKDDEILQHNNELARLQMRFDRARSDVIIWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKQLKEATFVSLEDTHKQLDMIQQFIQDLSDIWAEVKKKEQQQVRV", "length": 316 }, "evidence": [ { "id": "A6QQM8", "url": "https://omabrowser.org/oma/group/A6QQM8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5SV66-1", "protein_name": "Coiled-coil domain-containing protein 42", "gene_name": "Ccdc42", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLGMMEEEDLAEYFRLQYGERLLQLLQKFPNVEEQSDSPSIQLLEKKKEAKIMQEAMEHKKEAFQRRMETLNLRWEELGIKEEQLKAHIQKFEQFIQENDQKRIRALKKANKERELKRLRLRELAKAKQEMMALRLEHQKLSVKLQDYAIFNKYLEKVVENSEFEEIHEVIARYKTLVSMHHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQHNNELARLQMRFDRARSDVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKQLKESTQVSLEDTHKQLDMIQQFIQDLSDIWTEVKKKEQQQVRM", "length": 316 }, "evidence": [ { "id": "A6QQM8", "url": "https://omabrowser.org/oma/group/A6QQM8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96M95-1", "protein_name": "Coiled-coil domain-containing protein 42", "gene_name": "CCDC42", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLGIMEEEDLAEYFRLQYGERLLQMLQKLPNVEGASESPSIWLLEKKKETEIMHQTMVQKKKMFQRRMETLNLRWEELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERELKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYKTLVSMRHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQQNNELARLQMRFDRARSNVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKHLKEVTEVALEDTHKQLDMIQQFIQDRSDIWAEVKKKEQQRVRI", "length": 316 }, "evidence": [ { "id": "A6QQM8", "url": "https://omabrowser.org/oma/group/A6QQM8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VIY3-1", "protein_name": "DUF4200 domain-containing protein", "gene_name": "Dmel\\CG17564", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPRVKPTKKLDVLGNLDLRPEDAVGDYISSKQQNKFFVIPPNSDSAGDSIELIYVNNLREHEAMLKLQEEMLTSAKRQTKLNSARVRNMYKIQERLRRRFIEVNSFIKDCADKKRVAEKTAQAETLNHKELGEGIESFKDSIGELKAFREALKATVQEFQPYEKVLDEVVKVSDIFVSPKDCTDRCDALMLAQVEINKLEHQKLQDIENMRQRMVQITNDAALTVLGLKNDLAKLERSYNESRVQCLRWEKILAKTKDAINNNYMDKERTIDAITNLHRILLRRRDVHSFPARGDLDKVLDAIMGEVEILTGVVKEIESSDPSIKHEEARDKSLC", "length": 335 }, "evidence": [ { "id": "A6QQM8", "url": "https://omabrowser.org/oma/group/A6QQM8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A6QQM8", "url": "https://www.uniprot.org/uniprotkb/A6QQM8" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A6QQM8", "url": "https://www.uniprot.org/uniprotkb/A6QQM8" } ], "pmid": "" }, { "name": "manchette", "id": "GO:0002177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002177", "evidence": [ { "database": "UniProtKB", "id": "A6QQM8", "url": "https://www.uniprot.org/uniprotkb/A6QQM8" } ], "pmid": "" }, { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "A6QQM8", "url": "https://www.uniprot.org/uniprotkb/A6QQM8" } ], "pmid": "" }, { "name": "sperm head-tail coupling apparatus", "id": "GO:0120212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120212", "evidence": [ { "database": "UniProtKB", "id": "A6QQM8", "url": "https://www.uniprot.org/uniprotkb/A6QQM8" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A6QQM8", "url": "https://www.uniprot.org/uniprotkb/A6QQM8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "spermatid development", "id": "GO:0007286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "evidence": [ { "database": "UniProtKB", "id": "A6QQM8", "url": "https://www.uniprot.org/uniprotkb/A6QQM8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QQM8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 316, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QQM8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QQM8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QL92-1", "uniprot_ac": "A6QL92", "uniprot_id": "S35F5_BOVIN", "mass": { "chemical_mass": 59012.0, "monoisotopic_mass": 59012.0 }, "refseq": { "ac": "NP_001094712", "name": "solute carrier family 35 member F5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094712" }, "gene_names": [ { "name": "SLC35F5", "type": "recommended", "evidence": [ { "id": "A6QL92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QL92" } ] }, { "name": "SLC35F5", "type": "synonym", "evidence": [ { "id": "NP_001094712", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094712" } ] } ], "protein_names": [ { "name": "Solute carrier family 35 member F5", "type": "recommended", "evidence": [ { "id": "A6QL92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QL92/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 35 member F5", "type": "synonym", "evidence": [ { "id": "NP_001094712", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094712" } ] } ], "function": [ { "annotation": "Mediates choline transport, although the underlying transport mechanism remains to be elucidated.", "evidence": [ { "database": "UniProtKB", "id": "A6QL92", "url": "https://www.uniprot.org/uniprotkb/A6QL92#function" }, { "database": "UniProtKB", "id": "Q8WV83", "url": "https://www.uniprot.org/uniprotkb/Q8WV83#function" } ] }, { "annotation": "Putative solute transporter.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9ST09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST09#function" }, { "database": "UniProtKB", "id": "ARBA00037727", "url": "https://www.uniprot.org/uniprotkb/ARBA00037727#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QL92", "url": "https://www.uniprot.org/uniprotkb/A6QL92" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC35F5", "url": "https://www.uniprot.org/uniprotkb/A6QL92", "locus": { "chromosome": "2", "start_pos": 65335291, "end_pos": 65390429, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021103", "url": "https://www.ensembl.org/id/ENSBTAG00000021103" } ] } } ], "crossref": [ { "id": "A6QL92", "url": "https://alphafold.ebi.ac.uk/entry/A6QL92", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021103", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021103", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615480", "url": "https://www.ncbi.nlm.nih.gov/gene/615480", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR037185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615480", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615480", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MYGVYTI", "url": "https://omabrowser.org/oma/group/MYGVYTI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QL92", "url": "https://www.orthodb.org/?gene=A6QL92", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23051", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23051", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23051:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23051:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001094712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094712", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "32751", "url": "https://www.rhea-db.org/rhea/32751", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9ST09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST09-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQA3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QL92", "url": "https://www.uniprot.org/uniprotkb/A6QL92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QL92-1", "url": "https://www.uniprot.org/uniprotkb/A6QL92-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVPPRHHPGAGRPGALSSSPPFRLRSSKFSGIALQDLRKAFKIRLQMVCVFIMNRMNSQSSGFTQRKRMALGIVILLLVDVIWVASSELTSYVFTQYNKPFFSTFAKTSMFVLYLLGFIVWKPWRQQCTRGFRGKHATFFADAEGYFAACTTDTTMNSSLSEPLYVPVKFHDLPSEKPENTNIDTEKIPKKSRVRFSNIMEIRQLPSSHALEAKLSRMSYPTVKEQESLLKTVGKLTATQVAKISFFFCFVWFLANFSYQEALSDTQVAIVNILSSTSGLFTLILAAMFPSNSGDRFTLSKLLAVILSIGGVVLVNLSGSEKSPGRNTIGSIWSLVGAMLYAVYIVMIKRKVDREDKLDIPMFFGFVGLFNLLLLWPGFFLLHYTGFEDFEFPNKVVLMCIVINGLIGTVLSEFLWLWGCFLTSSLIGTLALSLTIPLSIIADMCMQKVQFSWLFFAGAIPVFFSFFIATLLCHYNNWDPVMVGIRRIFAFICRKHRIQKVPEDSEQCESLIPMHGVSQEDGAS", "length": 524, "header": "sp|A6QL92-1|S35F5_BOVIN Isoform 1 of Solute carrier family 35 member F5 OS=Bos taurus OX=9913 GN=SLC35F5 PE=2 SV=1 CANONICAL=A6QL92-1" }, "isoforms": [ { "isoform_ac": "A0AAA9ST09-1", "url": "https://www.uniprot.org/uniprotkb/A6QL92/entry#A0AAA9ST09-1", "sequence": { "sequence": "MGAIADLFTIMWQAPHLAQSALSSSPPFRLRSSKFSGIALQDLRKAFKIRLQMVCVFIMNRMNSQSSGFTQRKRMALGIVILLLVDVIWVASSELTSYVFTQYNKPFFSTFAKTSMFVLYLLGFIVWKPWRQQCTRGFRGKHATFFADAEGYFAACTTDTTMNSSLSEPLYVPVKFHDLPSEKPENTNIDTEKIPKKSRVRFSNIMEIRQLPSSHALEAKLSRMSYPTVKEQESLLKTVGKLTATQVAKISFFFCFVWFLANFSYQEALSDTQVAIVNILSSTSGLFTLILAAMFPSNSGDRFTLSKLLAVILSIGGVVLVNLSGSEKSPGRNTIGSIWSLVGAMLYAVYIVMIKRKVDREDKLDIPMFFGFVGLFNLLLLWPGFFLLHYTGFEDFEFPNKVVLMCIVINGLIGTVLSEFLWLWGCFLTSSLIGTLALSLTIPLSIIADMCMQKVQFSWLFFAGAIPVFFSFFIATLLCHYNNWDPVMVGIRRIFAFICRKHRIQKVPEDSEQCESLIPMHGVSQEDGAS", "length": 530, "header": "tr|A0AAA9ST09-1|S35F5_BOVIN Computationally mapped isoform of Solute carrier family 35 member F5 OS=Bos taurus OX=9913 GN=SLC35F5 PE=2 SV=1 CANONICAL=A6QL92-1" }, "locus": { "chromosome": "2", "start_pos": 65390382, "end_pos": 65340635, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114415.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114415.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086168.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086168.1" } ] } }, { "isoform_ac": "A0AAA9TQA3-1", "url": "https://www.uniprot.org/uniprotkb/A6QL92/entry#A0AAA9TQA3-1", "sequence": { "sequence": "MGASEESSKSGALSSSPPFRLRSSKFSGIALQDLRKAFKIRLQMVCVFIMNRMNSQSSGFTQRKRMALGIVILLLVDVIWVASSELTSYVFTQYNKPFFSTFAKTSMFVLYLLGFIVWKPWRQQCTRGFRGKHATFFADAEGYFAACTTDTTMNSSLSEPLYVPVKFHDLPSEKPENTNIDTEKIPKKSRVRFSNIMEIRQLPSSHALEAKLSRMSYPTVKEQESLLKTVGKLTATQVAKISFFFCFVVSL", "length": 251, "header": "tr|A0AAA9TQA3-1|S35F5_BOVIN Computationally mapped isoform of Solute carrier family 35 member F5 OS=Bos taurus OX=9913 GN=SLC35F5 PE=2 SV=2 CANONICAL=A6QL92-1" }, "locus": { "chromosome": "2", "start_pos": 65376339, "end_pos": 65364173, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128606.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128606.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099462.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099462.1" } ] } }, { "isoform_ac": "A6QL92-1", "url": "https://www.uniprot.org/uniprotkb/A6QL92/entry#A6QL92-1", "sequence": { "sequence": "MVPPRHHPGAGRPGALSSSPPFRLRSSKFSGIALQDLRKAFKIRLQMVCVFIMNRMNSQSSGFTQRKRMALGIVILLLVDVIWVASSELTSYVFTQYNKPFFSTFAKTSMFVLYLLGFIVWKPWRQQCTRGFRGKHATFFADAEGYFAACTTDTTMNSSLSEPLYVPVKFHDLPSEKPENTNIDTEKIPKKSRVRFSNIMEIRQLPSSHALEAKLSRMSYPTVKEQESLLKTVGKLTATQVAKISFFFCFVWFLANFSYQEALSDTQVAIVNILSSTSGLFTLILAAMFPSNSGDRFTLSKLLAVILSIGGVVLVNLSGSEKSPGRNTIGSIWSLVGAMLYAVYIVMIKRKVDREDKLDIPMFFGFVGLFNLLLLWPGFFLLHYTGFEDFEFPNKVVLMCIVINGLIGTVLSEFLWLWGCFLTSSLIGTLALSLTIPLSIIADMCMQKVQFSWLFFAGAIPVFFSFFIATLLCHYNNWDPVMVGIRRIFAFICRKHRIQKVPEDSEQCESLIPMHGVSQEDGAS", "length": 524, "header": "sp|A6QL92-1|S35F5_BOVIN Isoform 1 of Solute carrier family 35 member F5 OS=Bos taurus OX=9913 GN=SLC35F5 PE=2 SV=1 CANONICAL=A6QL92-1" }, "locus": { "chromosome": "2", "start_pos": 65376913, "end_pos": 65340635, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028113.5", "url": "https://www.ensembl.org/id/ENSBTAT00000028113.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028113.4", "url": "https://www.ensembl.org/id/ENSBTAP00000028113.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 207, "end_pos": 207, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QL92", "url": "https://www.uniprot.org/uniprotkb/A6QL92" } ], "site_lbl": "Ser207" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615480", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615480", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480Z1K0-1", "protein_name": "Solute carrier family 35 member F5", "gene_name": "SLC35F5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVPPRRHPGAGRPGALSSSPPFRLRSAKFSGIAFEDLRKAFKLRLQMVCVFIMNRMNSQSSGFTQRRRLALGIVILLLVDVIWVASSELTSYVFTQYNKPFFSTFAKTSMFVLYLLGFIIWKPWRQQCTRGFRGKHAAFFADAEGYFAACTTDTTMNSSLSEPLYVPVKFHDLPSEKPENTNIDTEKAPKKSRVRFSNIMEIRQLPSSHALEAKLSRMSYPTVKEQESLFKTVGKLTATQVAKISFFFCFVWFLANLSYQEALSDTQVAIVNILSSTSGLFTLILAAVFPSNSGDRFTLSKLLAVILSIGGVVLVNLSGSEKSAGRDTIGSIWSLVGAMLYAVYIVMIKRKVDREDKLDIPMFFGFVGLFNLLLLWPGFFLLHYTGFEDFEFPNKVVLMCIIVNGLIGTVLSEFLWLWGCFLTSSLIGTLALSLTIPLSIIADMCMQKVQFSWLFFAGAIHVFFSFFIVTLLCHYNNWDPVMVGIRRIFVFICRKHRIQRVPEDSEQCESLIPMHSVSQEDGAS", "length": 524 }, "evidence": [ { "id": "A6QL92", "url": "https://omabrowser.org/oma/group/A6QL92/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6G3G3-1", "protein_name": "Solute carrier family 35 member F5", "gene_name": "Slc35f5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGRMSPSWWTSWGPRVSRMGSRVPGEVPVYQAVRPGGLSSSPPFRQVSARFARIAFEDLREALATRLQMVYVFIMNRVNSQSSGFSQRRRMALGIVILLLVDVIWVASSELTSYVFTQYNKPFFSTFAKTSMFVLYLLGFIIWKPWRQQCTRGFRGKPAAFFADAEGYFAACTTDSSMSSSLSEPLYVPVKFHDLPSEKLESTNIGTEKPPKKSRVRFSNIMEIRQLPSSHALEAKLSRMSYPTVKDQESILKTVGKLTATQVAKISFFFCFVWFLANLSYQEALSDTQVAIVNILSSTSGLFTLILAAVFPSNSGDRFTLSKLLAVILSIGGVVLVNLSGSEKSAGRDTIGSIWSLAGAMFYAVYIVMIKRKVDREDKLDIPMFFGFVGLFNLLLLWPGFFLLHYTGFEDFEFPNKVVLLCIIINGLIGTVLSEFLWLWGCFLTSSLIGTLALSLTIPLSIIADMCMQKVQFSWLFFAGAIPVFFSFFIVTLLCHYNNWDPVMVGVRRVFAFICRKHRIQRVSEDSEQCESLISMHSVSQEDGAA", "length": 546 }, "evidence": [ { "id": "A6QL92", "url": "https://omabrowser.org/oma/group/A6QL92/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NEN4-1", "protein_name": "Solute carrier family 35 member F5", "gene_name": "SLC35F5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVWVFVMNRMSSQSSSSSQRRRMALGIVILLLVDVIWVASSELTSYVFTKYNKPFFSTFAKTSMFVLYLLGFIVWKPWRQQCTRGFRGRHAAFFADAEGYFAACTTDNAVNSSLLERNGLSSSFQWMKCCSSLNQMPVLSEPLYVPVKFHDLPTEKSGSNNNDTEKTPKKPRVRFSNIMEIRQLPSSHALEAKLSRMSYPAVKEQESILKTVGKLTATQVAKISFFFCFVWFLANFSYQEALSDTQVAIVNILSSTSGLFTLILAAVFPSNSGDRFTLSKLLAVFLSIGGVVLVNLSGSEKSPGRDTIGSLWSLVGAMLYAVYIVMIKRKVDREDKLDIPMFFGFVGLFNLLLLWPGFFLLHYTGFEAFEFPSKLIWMCIVINGLIGTVLSEFLWLWGCFLTSSLIGTLALSLTIPLSIIADMCMQKVQFSWLFFAGAVPVFFSFFIVTLLCHYNNWDPVMVGIRRVFAFICRKHRIQRMPEESEQCESLIPMHSVSQDGDSCCS", "length": 505 }, "evidence": [ { "id": "A6QL92", "url": "https://omabrowser.org/oma/group/A6QL92/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O49378-1", "protein_name": "EamA-like transporter family", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGWRYKAGLFLIGTVVIIWVTSAEVTQDIFTAYKQPFAVTYLGASLMIVYLPVAFLKDWLCRYLDRRSSKSNKIPALTDDSSVELGSPLRHKIIEMGLQGTITKKDSEEHLSSHEEEDERPLIGKVREEVQTLKQRKEITTKQIAMYGLYLAPIWFVTEYLSNAALARTSVASTTVLSSTSGLFTLFIGVFLGQDTLNLSKVVAVFVSMAGVVMTTLGKTWASDESQLNSSLNGERSLMGDLFGLLSAVSYGLFTVLLKKFAGEEGEGVDVQKLFGYIGLFTLVALWWLVWPLTALGIEPKFTIPHSVKVDEVVLANGFIGSVLSDYFWALSVVWTTPLVATLGMSLTIPLAMVADMMIHGRHYSAIYILGSTQVFAGFVIANISDLFSKKLGL", "length": 394 }, "evidence": [ { "id": "A6QL92", "url": "https://omabrowser.org/oma/group/A6QL92/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q03730-1", "protein_name": "Uncharacterized vacuolar membrane protein YML018C", "gene_name": "", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MVSKDQTSFNKRWTLGLLMLGLVIILWVLSSFLINLIFEDDSYRKPFFITYTNTAAFIFYLFPTAKAVVVNYKDTGRANVHRELIMEEEGTGSDSNRSVDMTSPLLTNLEAGTHANQKKRLTLYETIKLSAEFCILWFTANLVTNASLAFTSVASQTILSTTSSFFTLFIGAICHVESLSKSKVLGSFISFVGIIMVTKSDSHQRYQRHIADVSGDDNDAVQVLIGNLLALAGAVLYGVYSTLLKREVGDETRVNMKIFFGFVGLFNLLFLWPSLIVLDFFGWEPFSLPKDPKVVVIIFVNCLITFVSDFCWAKAMLLTSPLTVTVGLSITIPLAMFGDVIFKHKTMSALYLFGATLILGSFFIINKSSEEEHFENSITASNYESVEVPAANN", "length": 393 }, "evidence": [ { "id": "A6QL92", "url": "https://omabrowser.org/oma/group/A6QL92/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q8R314-1", "protein_name": "Solute carrier family 35 member F5", "gene_name": "Slc35f5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVPPRLHRGAGRPGGLSSLPPFGLGSARFAGIAFEDLREALATRLQMVYVFIMNRVNSQSSGFSQRRRMALGIVILLLVDVIWVASSELTSYVFTQYNKPFFSTFAKTSMFVLYLLGFIIWKPWRQQCTRGFRGKPAAFFADAEGYFAACTTDTSMSSSLSEPLYVPVKFHDLPSEKLESTNIGTEKTPKKSRVRFSNIMEIRQLPSSHALEAKLSRMSYPTVKDQESILKTVGKLTATQVAKISFFFCFVWFLANLSYQEALSDTQVAIVNILSSTSGLFTLILAAVFPSNSGDRFTLSKLLAVILSIGGVVLVNLSGSEKSAGRDTIGSIWSLAGAMFYAVYIVMIKRKVDREDKLDIPMFFGFVGLFNLLLLWPGFFLLHYTGFEDFEFPNKVVLLCIIINGLIGTVLSEFLWLWGCFLTSSLIGTLALSLTIPLSIIADMCMQKVQFSWLFFAGAIPVFFSFFIVTLLCHYNNWDPVMVGVRRVFAFICRKHRIQRVPEDSEQCESLISMHSVSQEDGAT", "length": 524 }, "evidence": [ { "id": "A6QL92", "url": "https://omabrowser.org/oma/group/A6QL92/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WV83-1", "protein_name": "Solute carrier family 35 member F5", "gene_name": "SLC35F5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVPPRRHRGAGRPGVLSSSPPFRLRSAKFSGIALEDLRRALKTRLQMVCVFVMNRMNSQNSGFTQRRRMALGIVILLLVDVIWVASSELTSYVFTQYNKPFFSTFAKTSMFVLYLLGFIIWKPWRQQCTRGLRGKHAAFFADAEGYFAACTTDTTMNSSLSEPLYVPVKFHDLPSEKPESTNIDTEKTPKKSRVRFSNIMEIRQLPSSHALEAKLSRMSYPVKEQESILKTVGKLTATQVAKISFFFCFVWFLANLSYQEALSDTQVAIVNILSSTSGLFTLILAAVFPSNSGDRFTLSKLLAVILSIGGVVLVNLAGSEKPAGRDTVGSIWSLAGAMLYAVYIVMIKRKVDREDKLDIPMFFGFVGLFNLLLLWPGFFLLHYTGFEDFEFPNKVVLMCIIINGLIGTVLSEFLWLWGCFLTSSLIGTLALSLTIPLSIIADMCMQKVQFSWLFFAGAIPVFFSFFIVTLLCHYNNWDPVMVGIRRIFAFICRKHRIQRVPEDSEQCESLISMHSVSQEDGAS", "length": 523 }, "evidence": [ { "id": "A6QL92", "url": "https://omabrowser.org/oma/group/A6QL92/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A6QL92", "url": "https://www.uniprot.org/uniprotkb/A6QL92" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "choline transmembrane transporter activity", "id": "GO:0015220", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015220", "evidence": [ { "database": "UniProtKB", "id": "A6QL92", "url": "https://www.uniprot.org/uniprotkb/A6QL92" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "choline transport", "id": "GO:0015871", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015871", "evidence": [ { "database": "UniProtKB", "id": "A6QL92", "url": "https://www.uniprot.org/uniprotkb/A6QL92" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" }, { "start_pos": 316, "end_pos": 318, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "32751", "name": "", "equation": "choline(out) = choline(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9XSA7-1" ], "evidence": [ { "id": "32751", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/32751" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q9XSA7", "gene_name": "CLIC4", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "Q9XSA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSA7" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QL92-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 524, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QL92-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QL92" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 207 ], "sequon_annotation_sites": [ { "start_pos": 157, "end_pos": 159 }, { "start_pos": 256, "end_pos": 258 }, { "start_pos": 316, "end_pos": 318 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QP24-1", "uniprot_ac": "A6QP24", "uniprot_id": "INKA2_BOVIN", "mass": { "chemical_mass": 31869.0, "monoisotopic_mass": 31869.0 }, "refseq": { "ac": "NP_001094731", "name": "PAK4-inhibitor INKA2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094731" }, "gene_names": [ { "name": "INKA2", "type": "recommended", "evidence": [ { "id": "A6QP24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP24" } ] }, { "name": "C1orf183", "type": "synonym", "evidence": [ { "id": "NP_001094731", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094731" } ] }, { "name": "C3H1orf183", "type": "synonym", "evidence": [ { "id": "NP_001094731", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094731" } ] }, { "name": "FAM212B", "type": "synonym", "evidence": [ { "id": "NP_001094731", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094731" }, { "id": "A6QP24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP24" } ] }, { "name": "INKA2", "type": "synonym", "evidence": [ { "id": "NP_001094731", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094731" } ] } ], "protein_names": [ { "name": "PAK4-inhibitor INKA2", "type": "recommended", "evidence": [ { "id": "A6QP24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP24/entry#names_and_taxonomy" } ] }, { "name": "PAK4-inhibitor INKA2", "type": "synonym", "evidence": [ { "id": "NP_001094731", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094731" } ] }, { "name": "family with sequence similarity 212 member B", "type": "synonym", "evidence": [ { "id": "NP_001094731", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094731" } ] }, { "name": "protein FAM212B", "type": "synonym", "evidence": [ { "id": "NP_001094731", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094731" } ] }, { "name": "uncharacterized protein C1orf183 homolog", "type": "synonym", "evidence": [ { "id": "NP_001094731", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094731" } ] } ], "function": [ { "annotation": "Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "A6QP24", "url": "https://www.uniprot.org/uniprotkb/A6QP24#function" }, { "database": "UniProtKB", "id": "Q96EL1", "url": "https://www.uniprot.org/uniprotkb/Q96EL1#function" }, { "database": "UniProtKB", "id": "A0AAA9TGT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT9#function" }, { "database": "UniProtKB", "id": "ARBA00045406", "url": "https://www.uniprot.org/uniprotkb/ARBA00045406#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QP24", "url": "https://www.uniprot.org/uniprotkb/A6QP24" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "INKA2", "url": "https://www.uniprot.org/uniprotkb/A6QP24", "locus": { "chromosome": "3", "start_pos": 31579137, "end_pos": 31565314, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022580", "url": "https://www.ensembl.org/id/ENSBTAG00000022580" } ] } } ], "crossref": [ { "id": "A6QP24", "url": "https://alphafold.ebi.ac.uk/entry/A6QP24", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022580", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022580", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616754", "url": "https://www.ncbi.nlm.nih.gov/gene/616754", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616754", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616754", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QPEPPRW", "url": "https://omabrowser.org/oma/group/QPEPPRW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QP24", "url": "https://www.orthodb.org/?gene=A6QP24", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28615", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28615", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28615:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28615:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15342", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15342", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001094731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094731", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TGT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QP24", "url": "https://www.uniprot.org/uniprotkb/A6QP24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QP24-1", "url": "https://www.uniprot.org/uniprotkb/A6QP24-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDCYLRRLKQELMSMKEVGDGLQDQMNCMMGALQELKLLQVQTALEQLEISGGGPAPGSPESPWTQLEPPQWEGSRGPVRPGACSPSNQASLGSTSSGKFPSHRSVCGRELATPPRTPLPEPQPSAQQGPELAEPDDWTSTLMSRGRNRQPLVLGDNVFADLVGNWLDLPELEKGGEKGETGEAGEPKGGRGQPRELGRRFALTANIFRKFLRSVRPDRDRLLKEKPGWVTPTASEPRAGRSQKVKKRSHSKGSGHCPFPGASEPRRGENASTGCPKALESSPSGFDINTAVWV", "length": 294, "header": "sp|A6QP24-1|INKA2_BOVIN Isoform 1 of PAK4-inhibitor INKA2 OS=Bos taurus OX=9913 GN=INKA2 PE=2 SV=1 CANONICAL=A6QP24-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TGT9-1", "url": "https://www.uniprot.org/uniprotkb/A6QP24/entry#A0AAA9TGT9-1", "sequence": { "sequence": "MSMKEVGDGLQDQMNCMMGALQELKLLQVQTALEQLEISGGGPAPGSPESPWTQLEPPQWEGSRGPVRPGACSPSNQASLGSTSSGKFPSHRSVCGRELATPPRTPLPEPQPSAQQGPELAEPDDWTSTLMSRGRNRQPLVLGDNVFADLVGNWLDLPELEKGGEKGETGEAGEPKGGRGQPRELGRRFALTANIFRKFLRSVRPDRDRLLKEKPGWVTPTASEPRAGRSQKVKKRSHSKGSGHCPFPGASEPRRGENASTGCPKALESSPSGFDINTAVWV", "length": 282, "header": "tr|A0AAA9TGT9-1|INKA2_BOVIN Computationally mapped isoform of PAK4-inhibitor INKA2 OS=Bos taurus OX=9913 GN=INKA2 PE=2 SV=1 CANONICAL=A6QP24-1" }, "locus": { "chromosome": "3", "start_pos": 31578305, "end_pos": 31577460, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108494.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108494.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097416.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097416.1" } ] } }, { "isoform_ac": "A6QP24-1", "url": "https://www.uniprot.org/uniprotkb/A6QP24/entry#A6QP24-1", "sequence": { "sequence": "MDCYLRRLKQELMSMKEVGDGLQDQMNCMMGALQELKLLQVQTALEQLEISGGGPAPGSPESPWTQLEPPQWEGSRGPVRPGACSPSNQASLGSTSSGKFPSHRSVCGRELATPPRTPLPEPQPSAQQGPELAEPDDWTSTLMSRGRNRQPLVLGDNVFADLVGNWLDLPELEKGGEKGETGEAGEPKGGRGQPRELGRRFALTANIFRKFLRSVRPDRDRLLKEKPGWVTPTASEPRAGRSQKVKKRSHSKGSGHCPFPGASEPRRGENASTGCPKALESSPSGFDINTAVWV", "length": 294, "header": "sp|A6QP24-1|INKA2_BOVIN Isoform 1 of PAK4-inhibitor INKA2 OS=Bos taurus OX=9913 GN=INKA2 PE=2 SV=1 CANONICAL=A6QP24-1" }, "locus": { "chromosome": "3", "start_pos": 31578305, "end_pos": 31565595, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030590.7", "url": "https://www.ensembl.org/id/ENSBTAT00000030590.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030567.4", "url": "https://www.ensembl.org/id/ENSBTAP00000030567.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 233, "start_aa": "Thr", "end_pos": 233, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr233", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616754", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616754", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AC30-1", "protein_name": "PAK4-inhibitor INKA2", "gene_name": "INKA2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDCYLRRLKQELMSMKEVGDGLQDQMNCMMGALQELKLLQVQTALEQLEISGGGPAPGCPGSPGTQPEPPRWEGGKGPASPLACSPSNPPALGSSTKFPSHRSVGGRDLAPLPRTRLPEHQSCAPQAPELGELDDWTSTLMSRGRNRQPLVLGDNVFADLVGNWLDLPELEKGGDRGDSGDAGAPKAGRAQPRELGRRFALTANIFRKFLRSVRPDRDRLLKEKPGWVTPTAPEPRAGRSQKVKKRSHSKGSGHCPFPGATEPRRGEIPPAGCPKALESSPSGFDINTAVWV", "length": 292 }, "evidence": [ { "id": "A6QP24", "url": "https://omabrowser.org/oma/group/A6QP24/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A3L7IFP9-1", "protein_name": "PAK4-inhibitor INKA2", "gene_name": "Inka2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRKESRDMDCYLRRLKQELMSMKEVGDGLQDQMNCMMGALQELKLLQVQTALEQLEISGGTPAFSCPENSQKQPECPCWQGSGGPTGPMAHPSSIQPSFDSSPKFPCHRSVCGKDLAVLPKTQLQEHNSCTHQGLEWEEPDDWTSTLMSRGRNRQPLVLGDNVFADLVGNWLDLPELEKGGEKSETGGPSEPKGEKGQSRELGRKFALTANIFRKFLRSVRPDRDRLLKEKPGWMTPMVSESRAGRSQKAKKRSLSKGSGRFPFSSSGEPRHTETPATSSPKALEPSRGGFDINTAVWV", "length": 299 }, "evidence": [ { "id": "A6QP24", "url": "https://omabrowser.org/oma/group/A6QP24/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8I6APB9-1", "protein_name": "PAK4-inhibitor INKA2", "gene_name": "Inka2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKKESRDMDCYLRRLKQELCSFYHQDSGRGMSMKEVGDGLQDQMNCMMGALQELKLLQVQTALEQLEISGGAPTFSCPKSSQEQTECPRWQGSGGPAGLAACPSSSQPSFDGSPKFPCRRSICGKELAVLPKTQMPEDQSCTQQGIEWVEPDDWTSTLMSRGRNRQPLVLGDNVFADLVGNWLDLPELEKGGERGETGGSGEPKGEKGQSRELGRKFALTANIFRKFLRSVRPDRDRLLKEKPGWMTPMVSESRAGRSKKVKKRSLSKGSGRFPFSSTGEPRHIETPATSSPKALEPSCRGFDINTAVWV", "length": 310 }, "evidence": [ { "id": "A6QP24", "url": "https://omabrowser.org/oma/group/A6QP24/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80VY2-1", "protein_name": "PAK4-inhibitor INKA2", "gene_name": "Inka2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTKESKDMDCYLRRLKQELMSMKEVGDGLQDQMNCMMGALQELKLLQVQTALEQLEISGGTPTFSCPESSQEQPECPRWQGSGGPAGPAAWTSSSQPSFDSSPKLPCRRSVCGKELAVLPKTQLPEEHQSCTQQGTEWVEPDDWTSTLMSRGRNRQPLVLGDNVFADLVGNWLDLPELEKGGEKGETGGSIEPKGEKGQSRELGRKFALTANIFRKFLRSVRPDRDRLLKEKPGWMTPMVSESRAGRSKKVKKRSLSKGSGRFPFSSTGEPRHIETPATSSPKALEPSCRGFDINTAVWV", "length": 300 }, "evidence": [ { "id": "A6QP24", "url": "https://omabrowser.org/oma/group/A6QP24/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A6QP24", "url": "https://www.uniprot.org/uniprotkb/A6QP24" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A6QP24", "url": "https://www.uniprot.org/uniprotkb/A6QP24" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A6QP24", "url": "https://www.uniprot.org/uniprotkb/A6QP24" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A6QP24", "url": "https://www.uniprot.org/uniprotkb/A6QP24" } ], "pmid": "" }, { "name": "protein serine/threonine kinase inhibitor activity", "id": "GO:0030291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030291", "evidence": [ { "database": "UniProtKB", "id": "A6QP24", "url": "https://www.uniprot.org/uniprotkb/A6QP24" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 270, "end_pos": 272, "annotation": "n_glycosylation_sequon" } ], 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"UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QR31-1", "url": "https://www.uniprot.org/uniprotkb/A6QR31-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAYEQVQKGPLKLKGVAELGVTKRKKKKKDKDKAKLLEAMGTSKKNEEEKRRGLDKRTPAQAAFEKMQEKRQMERILKKASKTHKQRVEDFNRHLDTLTEHYDIPKVSWTK", "length": 112, "header": "sp|A6QR31-1|FA32A_BOVIN Isoform 1 of Protein FAM32A OS=Bos taurus OX=9913 GN=FAM32A PE=3 SV=1 CANONICAL=A6QR31-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TZJ9-1", "url": "https://www.uniprot.org/uniprotkb/A6QR31/entry#A0AAA9TZJ9-1", "sequence": { "sequence": "MEAYEQVQKGPLKLKGVAELGVTKRKKKKKDKDKAKLLEAMGTSKKNEEEKRRGLDKRTPAQAAFEKMQEKRDFNRHLDTLTEHYDIPKVSWTK", "length": 94, "header": "tr|A0AAA9TZJ9-1|FA32A_BOVIN Computationally mapped isoform of Protein FAM32A OS=Bos taurus OX=9913 GN=FAM32A PE=3 SV=1 CANONICAL=A6QR31-1" }, "locus": { "chromosome": "7", "start_pos": 6837048, "end_pos": 6831838, "strand": "+", "evidence": [ { "database": "Ensembl 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"phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "A whole-genome assembly of the domestic cow, Bos taurus.", "journal": "Genome Biol.", "date": "2009", "authors": "Zimin Aleksey V, Delcher Arthur L, Florea Liliana, Kelley David R, Schatz Michael C, Puiu Daniela, Hanrahan Finnian, Pertea Geo, Van Tassell Curtis P, Sonstegard Tad S, Mar\u00e7ais Guillaume, Roberts Michael, Subramanian Poorani, Yorke James A, Salzberg Steven L", "evidence": [ { "database": "UniProtKB", "id": "A6QR31", "url": "https://www.uniprot.org/uniprotkb/A6QR31" } ], "reference": [ { "type": "PubMed", "id": "19393038", "url": "https://glygen.org/publication/PubMed/19393038" } ] } ], "pathway": [ { "id": "bta:508634", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508634", "resource": "KEGG Pathway" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major 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"o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "A6QLJ8-1", "uniprot_ac": "A6QLJ8", "uniprot_id": "PTER_BOVIN", "mass": { "chemical_mass": 39098.0, "monoisotopic_mass": 39098.0 }, "refseq": { "ac": "NP_001094752", "name": "N-acetyltaurine hydrolase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094752" }, "gene_names": [ { "name": "PTER", "type": "recommended", "evidence": [ { "id": "A6QLJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ8" } ] }, { "name": "PTER", "type": "synonym", "evidence": [ { "id": "NP_001094752", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094752" } ] } ], "protein_names": [ { "name": "N-acetyltaurine hydrolase", "type": "recommended", "evidence": [ { "id": "A6QLJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ8/entry#names_and_taxonomy" } ] }, { "name": "3.1.-.-", "type": "synonym", "evidence": [ { "id": "A6QLJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ8/entry#names_and_taxonomy" } ] }, { "name": "N-acetyltaurine hydrolase", "type": "synonym", "evidence": [ { "id": "NP_001094752", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094752" } ] }, { "name": "Phosphotriesterase-related protein", "type": "synonym", "evidence": [ { "id": "A6QLJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ8/entry#names_and_taxonomy" } ] }, { "name": "parathion hydrolase-related protein", "type": "synonym", "evidence": [ { "id": "NP_001094752", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094752" } ] }, { "name": "phosphotriesterase-related protein", "type": "synonym", "evidence": [ { "id": "NP_001094752", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094752" } ] } ], "function": [ { "annotation": "N-acetyltaurine hydrolase that regulates feeding by catalyzing the hydrolysis of N-acetyltaurine into taurine and acetate. N-acetyltaurine has anorexigenic and anti-obesity effects that are dependent on GFRAL receptor and GDF15. PTER also acts on other N-acetyl amino acids (Met, Ile, Leu, Val) and N-propionyltaurine, but at lower rates.", "evidence": [ { "database": "UniProtKB", "id": "A6QLJ8", "url": "https://www.uniprot.org/uniprotkb/A6QLJ8#function" }, { "database": "UniProtKB", "id": "Q60866", "url": "https://www.uniprot.org/uniprotkb/Q60866#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QLJ8", "url": "https://www.uniprot.org/uniprotkb/A6QLJ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTER", "url": "https://www.uniprot.org/uniprotkb/A6QLJ8", "locus": { "chromosome": "13", "start_pos": 30995226, "end_pos": 30919126, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016676", "url": "https://www.ensembl.org/id/ENSBTAG00000016676" } ] } } ], "crossref": [ { "id": "A6QLJ8", "url": "https://alphafold.ebi.ac.uk/entry/A6QLJ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016676", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016676", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00530", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00530", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "782020", "url": "https://www.ncbi.nlm.nih.gov/gene/782020", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001559", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001559", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017947", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017947", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782020", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782020", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MVKCGFI", "url": "https://omabrowser.org/oma/group/MVKCGFI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QLJ8", "url": "https://www.orthodb.org/?gene=A6QLJ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10819", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10819", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10819:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10819:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02126", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02126", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001094752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094752", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "67440", "url": "https://www.rhea-db.org/rhea/67440", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "81107", "url": "https://www.rhea-db.org/rhea/81107", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "81111", "url": "https://www.rhea-db.org/rhea/81111", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "81115", "url": "https://www.rhea-db.org/rhea/81115", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "81119", "url": "https://www.rhea-db.org/rhea/81119", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "81123", "url": "https://www.rhea-db.org/rhea/81123", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF7A200", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A200", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A200-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A200-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QLJ8", "url": "https://www.uniprot.org/uniprotkb/A6QLJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QLJ8-1", "url": "https://www.uniprot.org/uniprotkb/A6QLJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSLSGKVQTVLGLVEPGTLGRTLTHEHLTMTFDCCYYPPPPSHEAISKEPIIMKNLFWIQKNPYSHKENLQLNQETEAIKEELLDFKAKGGGALVENTTTGLSRDVRTLKWLAEETGVHIIAGAGFYVDATHSSETRAKSVEQLTDVLVNEILCGADGTSIKCGVIGEIGCSWPLTDSERKVLQATAHAQTQLGCPVIIHPGRNQSAPFQIIRVLQEAGGDISKTVMSHIDRTILDKKELLEFAQFGCYLEYDLFGTELFHYQFNPDIDMPNDNKRIKRVRLLVDEGYEDRILMAHDIHTKNRLTKYGGHGYSHILTNIVPKMLLRGITEGALDKILIENPKQWLTFK", "length": 349, "header": "sp|A6QLJ8-1|PTER_BOVIN Isoform 1 of N-acetyltaurine hydrolase OS=Bos taurus OX=9913 GN=PTER PE=2 SV=1 CANONICAL=A6QLJ8-1" }, "isoforms": [ { "isoform_ac": "A0AAF7A200-1", "url": "https://www.uniprot.org/uniprotkb/A6QLJ8/entry#A0AAF7A200-1", "sequence": { "sequence": "MSSLSGKVQTVLGLVEPGTLGRTLTHEHLTMTFDCCYYPPPPSHEAISKEPIIMKNLFWIQKNPYSHKENLQLNQETEAIKEELLDFKAKGGGALVENTTTGLSRDVRTLKWLAEETGVHIIAGAGFYVDATHSSETRAKSVEQLTDVLVNEILCGADGTSIKCGVIGEIGCSWPLTDSERKVLQATAHAQTQLGCPVIIHPGRNQSAPFQIIRVLQEAGGDISKTVMSHIDRVRLLVDEGYEDRILMAHDIHTKNRLTKYGGHGYSHILTNIVPKMLLRGITEGALDKILIENPKQWLTFK", "length": 302, "header": "tr|A0AAF7A200-1|PTER_BOVIN Computationally mapped isoform of N-acetyltaurine hydrolase OS=Bos taurus OX=9913 GN=PTER PE=2 SV=1 CANONICAL=A6QLJ8-1" }, "locus": { "chromosome": "13", "start_pos": 30994334, "end_pos": 30958371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075515.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075515.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061794.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061794.2" } ] } }, { "isoform_ac": "A6QLJ8-1", "url": "https://www.uniprot.org/uniprotkb/A6QLJ8/entry#A6QLJ8-1", "sequence": { "sequence": "MSSLSGKVQTVLGLVEPGTLGRTLTHEHLTMTFDCCYYPPPPSHEAISKEPIIMKNLFWIQKNPYSHKENLQLNQETEAIKEELLDFKAKGGGALVENTTTGLSRDVRTLKWLAEETGVHIIAGAGFYVDATHSSETRAKSVEQLTDVLVNEILCGADGTSIKCGVIGEIGCSWPLTDSERKVLQATAHAQTQLGCPVIIHPGRNQSAPFQIIRVLQEAGGDISKTVMSHIDRTILDKKELLEFAQFGCYLEYDLFGTELFHYQFNPDIDMPNDNKRIKRVRLLVDEGYEDRILMAHDIHTKNRLTKYGGHGYSHILTNIVPKMLLRGITEGALDKILIENPKQWLTFK", "length": 349, "header": "sp|A6QLJ8-1|PTER_BOVIN Isoform 1 of N-acetyltaurine hydrolase OS=Bos taurus OX=9913 GN=PTER PE=2 SV=1 CANONICAL=A6QLJ8-1" }, "locus": { "chromosome": "13", "start_pos": 30994334, "end_pos": 30958371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022174.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022174.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022174.4", "url": "https://www.ensembl.org/id/ENSBTAP00000022174.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:782020", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782020", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A481AHI1-1", "protein_name": "N-acetyltaurine hydrolase", "gene_name": "PTER", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSSISGKVQTVLGPVEPSQLGRTLTHEHLTMTFDCSYYPPPPSHEVISKEPIRMKNLFWIQKNPYSHKENLQLNQETEAIKEELLDFKANGGGALVENTTTGISRDVQTLKRLAEETGVQIISGAGFYVDATHSSETRAMSVEQLTNVLVNEILHGADGTSIKCGVIGEIGCSWPLTESERKVLQATAHAQVQLGCPVIIHPGRNPSAPFQIIRVLQEAGADISKTVMSHLDRTILDKKELLEFAQFGCYLEYDLFGTELFHYQFNPDIDMPNDNKRIKRVRLLVAEGYEDRILMAHDIHTKHRLTKYGGHGYSHILTNIVPKMLLRGITQDALDKILIENPKQWLTFK", "length": 349 }, "evidence": [ { "id": "A6QLJ8", "url": "https://omabrowser.org/oma/group/A6QLJ8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XHV6-1", "protein_name": "N-acetyltaurine hydrolase", "gene_name": "PTER", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSSLSGKAQTVLGLVEPEQLGCTLTHEHLSMDYSSFFCPPSPGQEPLSEGPIKMKNLFWIKQNPYSHKDNLLLCQEIDAVREELLHFKAAGGGTIVENTTTGIRRDMKTLKKLAEETGVHIIAGAGFYVDSTHSSQTQAMTVEQLTDIIVDEILHGADGTDIRCGVVGEIGCSWPMTASERRVLQATAHAQAQIGCPIIIHPGRHSDAPFQIVRILQEAGADASKTVMSHLDRSIFDTKKLLEFAKLGCYLEYDLFGTEFIHYQFQPDIDMPSDNDRIARIRMLIDEGYEDRILMAHDVHTKNRLMKYGGHGYSHILKNIVPKMLIRGISQDKIDKILIGNPKRWLTFK", "length": 349 }, "evidence": [ { "id": "A6QLJ8", "url": "https://omabrowser.org/oma/group/A6QLJ8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q0P3Z2-1", "protein_name": "N-acetyltaurine hydrolase", "gene_name": "pter", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSELRGKVQTVLGQIEPDQLGRTMTHEHLTMSFECSHVPPAPGDEGLSLAPIEMKHLHWLQQNPYSHHENLLLNQELEAVKEELLCYRKAGGGTIVENTTTGINRNLPALKQLAKETGVHVIAGAGYYVDVTHSEETRKMTVEKLTDVIVSEVLHGADGTDIRCGVIGEIGTSWPITESEKKVLQATAHAQTRLGCPVIIHPGRDNRAPVEVIRILQEAGGDISKTVMSHLDRSIYDHGELLEFARMGSYLEYDLFGTEVLNYQFNCNVDMPSDSQRVQSLKFLIQEGYEDRILIAHDIHTKHRLTKYGGHGFSHILKNIVPKMLSRGITQNQVDKILIENPKRWLTFK", "length": 349 }, "evidence": [ { "id": "A6QLJ8", "url": "https://omabrowser.org/oma/group/A6QLJ8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q54BV6-1", "protein_name": "N-acetyltaurine hydrolase", "gene_name": "pter", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTERIGKIQTIKGLIEKDELGITHMHEHIFINYLDYFEKPNEQELKMCCLGGGSGSGNSNSNKTIEDLSNEKISLINNHWVQYNYNKNLHNLQLNEMEIAIRELEMFKRNGGSTIVEVTTKGIGRDPLQCLKVSQELNINIVMGAGYYLDKSISQFVQSMTEKQMEDEIVKQCLIGIDDTSIKAGIIGEVGCSFPLTNNEKKSLIASAKAQQRTGLSISIHPGRSQTAPLEIIQILKDSGADLSRVIIGHIDRTIHDINILLETAKTGCILEFDLFGMEISHYPFGGEVGMPSDNQRIEWIYQLIKHGYGENIVISHDIYTKHRLVSYGGHGYSHILFNIIPRMKKFGYSDTDINNILINNPKRLLTIIK", "length": 370 }, "evidence": [ { "id": "A6QLJ8", "url": "https://omabrowser.org/oma/group/A6QLJ8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q60866-1", "protein_name": "N-acetyltaurine hydrolase", "gene_name": "Pter", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSLSGKVQTVLGLVEPSQLGRTLTHEHLTMTFDSFYCPPPPCHEVTSKEPIMMKNLFWIQKNPYSHRENLQLNQEVGAIREELLYFKAKGGGALVENTTTGLSRDVHTLKWLAEQTGVHIIAGAGFYVDATHSAATRAMSVEQLTDVLINEILHGADGTSIKCGVIGEIGCSWPLTDSERKILEATAHAQAQLGCPVIIHPGRNPGAPFQIIRILQEAGADISKTVMSHLDRTIFDKKELLEFAQLGCYLEYDLFGTELLNYQLSPDIDMPDDNKRIRRVHFLVDEGYEDRILMAHDIHTKHRLMKYGGHGYSHILTNIVPKMLLRGLTERVLDKILIENPKQWLTFK", "length": 349 }, "evidence": [ { "id": "A6QLJ8", "url": "https://omabrowser.org/oma/group/A6QLJ8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q63530-1", "protein_name": "N-acetyltaurine hydrolase", "gene_name": "Pter", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSLSGKVQTVLGPVEPSQLGRTLTHEHLTMAFDSFYCPPPPCQEAASREPIMMKNLFWIQKNPYSHQENLQLNQEVEAVREELLYFKAKGGGAVVENTTTGLSRDVRTLKWLAEQTGVHIIAGAGFYVDATHSAATRAMSVEQLTDVLISEILHGADGTSIKCGVIGEIGCSWPLTDSERKVLQATAHAQAQLGCPVIIHPGRNPGAPFQIIRVLQEAGADISKTVMSHLDRSIFDKKELLEFAQLGCYLEYDLFGTELLNYQLSPDIDMPDDNKRIRRVRFLVNEGYEDRILMAHDIHTKHRLMKYGGHGYSHILTNVVPKMLLRGLTERVLDKILRENPKQWLTFK", "length": 349 }, "evidence": [ { "id": "A6QLJ8", "url": "https://omabrowser.org/oma/group/A6QLJ8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96BW5-1", "protein_name": "N-acetyltaurine hydrolase", "gene_name": "PTER", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSLSGKVQTVLGLVEPSKLGRTLTHEHLAMTFDCCYCPPPPCQEAISKEPIVMKNLYWIQKNAYSHKENLQLNQETEAIKEELLYFKANGGGALVENTTTGISRDTQTLKRLAEETGVHIISGAGFYVDATHSSETRAMSVEQLTDVLMNEILHGADGTSIKCGIIGEIGCSWPLTESERKVLQATAHAQAQLGCPVIIHPGRSSRAPFQIIRILQEAGADISKTVMSHLDRTILDKKELLEFAQLGCYLEYDLFGTELLHYQLGPDIDMPDDNKRIRRVRLLVEEGCEDRILVAHDIHTKTRLMKYGGHGYSHILTNVVPKMLLRGITENVLDKILIENPKQWLTFK", "length": 349 }, "evidence": [ { "id": "A6QLJ8", "url": "https://omabrowser.org/oma/group/A6QLJ8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VHF2-1", "protein_name": "Phosphotriesterase-related protein", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSTVQTVLGTITPNLLGRTLTHEHVALDFEHFYRPPPPDFESELKAKISMSTLGYVRLYPYSSKENVRFYDGEALEAAKKDVLLYKKHGGGSIVENSSYGLKRNLEFIVELAKSTGVHFIAGTGHYIHAMQDASHASLTVEQMSDLYSKDIITGLQVNGKVVKCGFIGEVASVYPIHDFEKNAIKAAGEIQEVLGCGVSMHPHRVTKAPFEIMRLYLEAGGRADKCVMSHLDRTIFDIDELLEFAKLGCYIQYDLFGTECSFYQLNTSVDMISDGQRIDNLIKLIKEGLVDKLLMSHDIHTKHRLTSYGGHGYHHIHTNILPRMFDRGVTLEQVEQMTVTNPAKWLAFDP", "length": 350 }, "evidence": [ { "id": "A6QLJ8", "url": "https://omabrowser.org/oma/group/A6QLJ8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A6QLJ8", "url": "https://www.uniprot.org/uniprotkb/A6QLJ8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": 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"https://www.ensembl.org/id/ENSBTAG00000023412" } ] } } ], "crossref": [ { "id": "A6QL94", "url": "https://alphafold.ebi.ac.uk/entry/A6QL94", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023412", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023412", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "786878", "url": "https://www.ncbi.nlm.nih.gov/gene/786878", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029389", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029389", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:786878", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786878", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WKGVFLW", "url": "https://omabrowser.org/oma/group/WKGVFLW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QL94", "url": "https://www.orthodb.org/?gene=A6QL94", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR36470", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36470", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36470:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36470:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1300645", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1300645", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001099112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099112", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QL94", "url": "https://www.uniprot.org/uniprotkb/A6QL94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QL94-1", "url": "https://www.uniprot.org/uniprotkb/A6QL94-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDLWLLLLLPLSLAAFHGVKGCLECDPKFIEEVKSLLGKLVPPEVPGRTHMLERQMKEMIRLSFKVSHRDKMLRVLAVQKVVDLRTWLKIELDKLSKEKWKGVFILQGRLLDIRKNLDSKLEKLLKKFSEVACSEDCVVTEGPILDCWTCLRITSRCFRGEYCEEDDPKKAESREIGLFLILLAEGVILGGVLLLFHFCISHQRKMKAIRRSLKTYLEKKLEELMGIKDEKEKDFRGRE", "length": 240, "header": "sp|A6QL94-1|IZUM3_BOVIN Isoform 1 of Izumo sperm-egg fusion protein 3 OS=Bos taurus OX=9913 GN=IZUMO3 PE=2 SV=1 CANONICAL=A6QL94-1" }, "isoforms": [ { "isoform_ac": "A6QL94-1", "url": "https://www.uniprot.org/uniprotkb/A6QL94/entry#A6QL94-1", "sequence": { "sequence": "MGDLWLLLLLPLSLAAFHGVKGCLECDPKFIEEVKSLLGKLVPPEVPGRTHMLERQMKEMIRLSFKVSHRDKMLRVLAVQKVVDLRTWLKIELDKLSKEKWKGVFILQGRLLDIRKNLDSKLEKLLKKFSEVACSEDCVVTEGPILDCWTCLRITSRCFRGEYCEEDDPKKAESREIGLFLILLAEGVILGGVLLLFHFCISHQRKMKAIRRSLKTYLEKKLEELMGIKDEKEKDFRGRE", "length": 240, "header": "sp|A6QL94-1|IZUM3_BOVIN Isoform 1 of Izumo sperm-egg fusion protein 3 OS=Bos taurus OX=9913 GN=IZUMO3 PE=2 SV=1 CANONICAL=A6QL94-1" }, "locus": { "chromosome": "8", "start_pos": 19636814, "end_pos": 19634443, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031901.4", "url": "https://www.ensembl.org/id/ENSBTAT00000031901.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031847.3", "url": "https://www.ensembl.org/id/ENSBTAP00000031847.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:786878", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786878", "resource": "KEGG Pathway" }, { "id": "R-BTA-1300645", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1300645", "resource": "Reactome", "description": "Acrosome Reaction and Sperm:Oocyte Membrane Binding" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7I754-1", "protein_name": "Izumo sperm-egg fusion protein 3", "gene_name": "Izumo3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGDLWVLLFLPLYLAAFRGVKGCLECDPRFIEDVRTLLAMLIPVEVPGRIQLLDRQHKEIIQLSSKVSHMDKTLRLLAVRNVIKMREWLKHEFYRLGNETWKGAFIMQGKLLQVRQNLGYQLKESLKSFSEVACSEDCIVIEGPVLDCWTCLRLTTRCFRGDYCKDENPKKADNREIALYLILIAEAVILASAVLLFHFCISHRRKMKVIRRTLKTYLEKKLEELVGIVDKDDENKDSETQKSNLQPQTGDPSGVESELQTGT", "length": 263 }, "evidence": [ { "id": "A6QL94", "url": "https://omabrowser.org/oma/group/A6QL94/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A6PWV3-1", "protein_name": "Izumo sperm-egg fusion protein 3", "gene_name": "Izumo3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGDLWVLLFSSLSLAAFHGVRGCLECDPKFTEDVRTLLGNLVPLEVPDRNQLLDRQHKEITHISSKVSHKDKMLRLLAVRNVIKLREWLKDEFYRLGNETWKGVFIIQGNLLEIRQNLEKKLTQIIKNFSEVACSEDCIVIEGPVLDCWNCLRMTTRCFKGDYCQDEDPKTAENREISLYLIFIAEAVILASAVLLFHVCISHRRKMKAIRRTLKTYLEKKLEELVEMIYKDDGEKNLEFGRSNSNSLTGEPTCAESEMQTGT", "length": 263 }, "evidence": [ { "id": "A6QL94", "url": "https://omabrowser.org/oma/group/A6QL94/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZRD5-1", "protein_name": "IZUMO family member 3", "gene_name": "Izumo3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRDLWILLFLPLFLAAFHGVKGCLECDPKFTEDVRILLENLVPLEVPERNQLLERQHKEITHISSKVSHKDKMLRLLAVRNVVKLRVWLKDEFYRLGNETWKGVFIIRGKLLAVRQNLENKLTQILKNFSEVACSEDCIVTEGPVLDCWTCLRMTTRCFRGEYCQDDDPREAENREISLYLIFTAEAVILASAVLLFHVCVTHRRKMRQIRRTLKTYLEKKLEELVEIIYKDEKKDSEFGKSNTQSLTGQPPNAESEMKTGT", "length": 262 }, "evidence": [ { "id": "A6QL94", "url": "https://omabrowser.org/oma/group/A6QL94/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5VZ72-1", "protein_name": "Izumo sperm-egg fusion protein 3", "gene_name": "IZUMO3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGDLWLFLLLPLSAFHGVKGCLECDPKFIEDVGSLLGNLIPSEVPGRTQLLERQIKEMIHLSFKVSHSDKRLRVLAVQQVVKLRTWLKNEFYKLGNETWKGVFIYQGKLLDVCQNLESKLKELLKNFSEIACSEDCIVVEGPILDCWTCLRMTNRCFKGEYCGDEDPRKAENREIALFLILLATAVILGSAVLLFHFCIFHRRKMKAIRRSLKEYVEKKLEELMGKIDEKEEKDFRLRK", "length": 239 }, "evidence": [ { "id": "A6QL94", "url": "https://omabrowser.org/oma/group/A6QL94/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A6QL94", "url": "https://www.uniprot.org/uniprotkb/A6QL94" } ], "pmid": "" }, { "name": "inner acrosomal membrane", "id": "GO:0002079", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002079", "evidence": [ { "database": "UniProtKB", "id": "A6QL94", "url": "https://www.uniprot.org/uniprotkb/A6QL94" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A6QL94", "url": "https://www.uniprot.org/uniprotkb/A6QL94" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "acrosome assembly", "id": "GO:0001675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001675", "evidence": [ { "database": "UniProtKB", "id": "A6QL94", "url": "https://www.uniprot.org/uniprotkb/A6QL94" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QL94-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 240, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QL94-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QL94" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QLC7-1", "uniprot_ac": "A6QLC7", "uniprot_id": "TPC11_BOVIN", "mass": { "chemical_mass": 128272.0, "monoisotopic_mass": 128272.0 }, "refseq": { "ac": "NP_001095667", "name": "trafficking protein particle complex subunit 11", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095667" }, "gene_names": [ { "name": "TRAPPC11", "type": "recommended", "evidence": [ { "id": "A6QLC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLC7" } ] }, { "name": "C27H4orf41", "type": "synonym", "evidence": [ { "id": "NP_001095667", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095667" } ] }, { "name": "TRAPPC11", "type": "synonym", "evidence": [ { "id": "NP_001095667", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095667" } ] } ], "protein_names": [ { "name": "Trafficking protein particle complex subunit 11", "type": "recommended", "evidence": [ { "id": "A6QLC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLC7/entry#names_and_taxonomy" } ] }, { "name": "UPF0636 protein C4orf41 homolog", "type": "synonym", "evidence": [ { "id": "NP_001095667", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095667" } ] }, { "name": "trafficking protein particle complex 11", "type": "synonym", "evidence": [ { "id": "NP_001095667", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095667" } ] }, { "name": "trafficking protein particle complex subunit 11", "type": "synonym", "evidence": [ { "id": "NP_001095667", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095667" } ] } ], "function": [ { "annotation": "Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.", "evidence": [ { "database": "UniProtKB", "id": "A6QLC7", "url": "https://www.uniprot.org/uniprotkb/A6QLC7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QLC7", "url": "https://www.uniprot.org/uniprotkb/A6QLC7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRAPPC11", "url": "https://www.uniprot.org/uniprotkb/A6QLC7", "locus": { "chromosome": "27", "start_pos": 14414602, "end_pos": 14375208, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007422", "url": "https://www.ensembl.org/id/ENSBTAG00000007422" } ] } } ], "crossref": [ { "id": "A6QLC7", "url": "https://alphafold.ebi.ac.uk/entry/A6QLC7", "database": "AlphaFoldDB", "categories": [] }, { "id": "537211", "url": "https://www.ncbi.nlm.nih.gov/gene/537211", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR021773", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021773", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025876", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025876", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:537211", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537211", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A6QLC7", "url": "https://www.orthodb.org/?gene=A6QLC7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14374", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14374", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14374:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14374:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11817", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11817", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12742", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12742", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095667", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QLC7", "url": "https://www.uniprot.org/uniprotkb/A6QLC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QLC7-1", "url": "https://www.uniprot.org/uniprotkb/A6QLC7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPTQWDFPVELCCRPMAFVTLTGLDVVYNAVHRAVWDAFCANRRADRVPISFKVLPGDHEYPKCRPKRTSYEWYIPKGILKTGWMNKHLNLVPALVVVFYELDWDEPQWKEKQSECATRVEIVRQSLQGRNTKVAVVLIQKKTPLPPGEDVIASERAAALCNACELSGKSLFVLPHTDHLVGYIIRLENAFYEHAQTYYYTEIRRVKSHKEFLNKTTHQLLFVRHQFKIAFFSELKQDTQNALKNYRTAYNLVHELRAHETNILEIKTMAGFINYKICRLCFQHNTPLDAIAQFRKHIDLCKKKIGSAELAFEHAAWMSKQFQAFGDLFDEAIKLGLTAIQTQNPGFYYQQAAYYAQERKQLAKALCNHEASVTYPNPDPLETQAGVLDFYGQRSWRQGVLSFDLSDPEKEKVGILAIQLKERSVVHSEVIITLLSNAVAQFKKYKCPRMKSHLMVQMGEEYYYAKDYTKALKLLDYVMCDYRSEGWWTLLTSILTTALKCSYLMAQLKDYITYSLELLGRASTLKDDQKSRIEKNLINVLMNESPDPEPDCDILAVKTAQKLWVDRISLAGSNVFTIGVQDFVPFVQCKAKFHAPSFHVDVPVQFDVYLKADCPHPIRFSKLCISFNNQEYNQFCVIEEASKASDVLENLTQGKMCLVPGKTRKFLFKFVAKTEDVGKKIEITSVDLVLGSEAGRCVVLNWQGGGGDAASAQEALQASRSFKRRPRLPDSEVHWDGIVIQASTMIISRVPNISVHLRHDPPALTNEMYCLVVTVQSHEKSPIRDVKLTAGLKPGQDANLTQKTHVTLHGTELCDESYPALLTDIPIGDLQPGEQLEKAVYVRCGTVGSRMFLVYVSYLINTAIEGKETVCKCHKDETVTIETVFPFDVAVKFVSTKFEHLERVYADIPFLLMTDLLSASPWALTIVSSELQLAPSMTPVDQLESQVDRVVLQTGESASECFCLRCPSVGNVEGGVATGHYVISWKRTSATDGVPVISTVITLPHVIVENIPLHVNADLPSFGRVRESLPVRYHLQNKTDLVQDVEISVEPSDAFMFSGLKQIRLRILPGTEQEMLYNFYPLMAGYQQLPSLNINLLRFPNFTNQLLRRFIPTSIFVKPQGRLVDDASIAAA", "length": 1133, "header": "sp|A6QLC7-1|TPC11_BOVIN Isoform 1 of Trafficking protein particle complex subunit 11 OS=Bos taurus OX=9913 GN=TRAPPC11 PE=2 SV=1 CANONICAL=A6QLC7-1" }, "isoforms": [ { "isoform_ac": "A6QLC7-1", "url": "https://www.uniprot.org/uniprotkb/A6QLC7/entry#A6QLC7-1", "sequence": { "sequence": 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"categories": [ "Protein Classification" ] }, { "id": "PTHR23095", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23095", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23095:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23095:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14893", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14893", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20846", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20846", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001098461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098461", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QLK5", "url": "https://www.uniprot.org/uniprotkb/A6QLK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QLK5-1", "url": "https://www.uniprot.org/uniprotkb/A6QLK5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAMTLLEDWCRGMDVNSQRALLVWGIPVNCDEAEIEETLQAAMPQVHYRVLGRMFWREENAKAALLELTGTVDYAAIPREMPGKGGVWKVVFKPPTSDAEFLERLHLFLAREGWTVQDVARVLGFENSSPAPGPDMPAEMLNYILDNVIKPLIESIWYKKLTLFSGRDIPGPGEETFEPWLEHANEVIEEWQVSDIEKRRRLMESLRGPAADVIRILKTNNPDITTAECLKALEQVFGSVESSRDVQVRFLNTYQNPGEKLSAYVIRLEPLLQKVVEKGAIDKENVNQARLEQVIAGANHSGAIRRQLWLTGAAEGPAPNLFQLLVQIREEEAKEEEAAAEAALLQLGLEGHF", "length": 353, "header": "sp|A6QLK5-1|PNMA1_BOVIN Isoform 1 of Paraneoplastic antigen Ma1 homolog OS=Bos taurus OX=9913 GN=PNMA1 PE=2 SV=1 CANONICAL=A6QLK5-1" }, "isoforms": [ { "isoform_ac": "A6QLK5-1", "url": "https://www.uniprot.org/uniprotkb/A6QLK5/entry#A6QLK5-1", "sequence": { "sequence": "MAMTLLEDWCRGMDVNSQRALLVWGIPVNCDEAEIEETLQAAMPQVHYRVLGRMFWREENAKAALLELTGTVDYAAIPREMPGKGGVWKVVFKPPTSDAEFLERLHLFLAREGWTVQDVARVLGFENSSPAPGPDMPAEMLNYILDNVIKPLIESIWYKKLTLFSGRDIPGPGEETFEPWLEHANEVIEEWQVSDIEKRRRLMESLRGPAADVIRILKTNNPDITTAECLKALEQVFGSVESSRDVQVRFLNTYQNPGEKLSAYVIRLEPLLQKVVEKGAIDKENVNQARLEQVIAGANHSGAIRRQLWLTGAAEGPAPNLFQLLVQIREEEAKEEEAAAEAALLQLGLEGHF", "length": 353, "header": "sp|A6QLK5-1|PNMA1_BOVIN Isoform 1 of Paraneoplastic antigen Ma1 homolog OS=Bos taurus OX=9913 GN=PNMA1 PE=2 SV=1 CANONICAL=A6QLK5-1" }, "locus": { "chromosome": "10", "start_pos": 85118651, "end_pos": 85117593, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012212.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012212.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012212.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012212.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538718", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538718", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LVI2-1", "protein_name": "Paraneoplastic antigen Ma1", "gene_name": "Pnma1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MALTLLEDWCRGMDVNSQRALLVWGIPVNCDEAEIEETLQAAMPQVPYRVLGRMFWREENAKAALLELTGEVDYSLIPREMPGKGGLWKVFFKPPTSDAEFLERLHLFLAREGWTVQDVARVLGFQNPAPAPGPEMPAEMLNYILDNVIQPLVESIWYKKLTLFSGRDIPGPGEETFDSWLEHSNEVIEEWQVSDIEKRRRLMESLRGPAADVIRILKTNNPAITTAECLKALEQVFGSVESSRDTQVRFLNTYQNPGEKLSSYVIRLEPLLQKVVEKGAIDKDNVNQARLEQVIAGANHSGAIRRQLWLTGAAERPAPNLFQLLVQIREEEAKEEEEEAEAALLQLGLEGHF", "length": 353 }, "evidence": [ { "id": "A6QLK5", "url": "https://omabrowser.org/oma/group/A6QLK5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1S3J2-1", "protein_name": "PNMA family member 1", "gene_name": "PNMA1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAMTLLEDWCRGMDVNSQRALLVWGIPVNCDETEIEETFQAAMPQVPYRVLGRMFWREENAKAALLELTGAVDYAAIPREMPGKGGVWKVVFKPPTSDAEFLERLHLFLAREGWTVQDVARVLGFQNPTPAPGPEMPAEMLNYILDNVIQPLVESIWYKKLTLFSGRDIPGPGEEAFDPWLEHTNEVIEEWQVPDVEKRRRLMESLRGPAADVIRILKTNNPAITTAECLKALEQVFGSVESSRDAQVRFLNTYQNPGEKLSAYVIRLEPLLQKVVEKGAIDKDNVNQARLEQVIAGANHSGAIRRQLWLTGAAEGPAPNLFQLLVQIREEEAKEEEEEAEAALLQLGLEGHF", "length": 353 }, "evidence": [ { "id": "A6QLK5", "url": "https://omabrowser.org/oma/group/A6QLK5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8C1C8-1", "protein_name": "Paraneoplastic antigen Ma1 homolog", "gene_name": "Pnma1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAMTLLEDWCRGMDVNSQRALLVWGIPVNCDETEIEETLQAAMPQVSYRVLGRMFWREENAKAALLELTGAVDYSLIPREMPGKGGLWKVVFKPPTSDAVFLERLHLFLAREGWTVQDVARVLGFQNPAPAPGPEMPAEMLNYILDNVIQPLVESIWYKKLTLFSGKDIPGPGEETFDSWLEHSNEIIEEWQVSDIEKRRRLMESLRGPAADVIRILKTNNAAITTAECLKALEQVFGSVESSRDAQVRFLNTYQNPGEKLSSYVIRLEPLLQKVVDKGVIDKDNVNQARLEQVIAGANHSGALRRQLWLAGAEEGPAPNLFQLLVQIREEEAKKEEEEAEAALLQLGLEGHF", "length": 353 }, "evidence": [ { "id": "A6QLK5", "url": "https://omabrowser.org/oma/group/A6QLK5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8ND90-1", "protein_name": "Paraneoplastic antigen Ma1", "gene_name": "PNMA1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAMTLLEDWCRGMDVNSQRALLVWGIPVNCDEAEIEETLQAAMPQVSYRMLGRMFWREENAKAALLELTGAVDYAAIPREMPGKGGVWKVLFKPPTSDAEFLERLHLFLAREGWTVQDVARVLGFQNPTPTPGPEMPAEMLNYILDNVIQPLVESIWYKRLTLFSGRDIPGPGEETFDPWLEHTNEVLEEWQVSDVEKRRRLMESLRGPAADVIRILKSNNPAITTAECLKALEQVFGSVESSRDAQIKFLNTYQNPGEKLSAYVIRLEPLLQKVVEKGAIDKDNVNQARLEQVIAGANHSGAIRRQLWLTGAGEGPAPNLFQLLVQIREEEAKEEEEEAEATLLQLGLEGHF", "length": 353 }, "evidence": [ { "id": "A6QLK5", "url": "https://omabrowser.org/oma/group/A6QLK5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VHZ4-1", "protein_name": "Paraneoplastic antigen Ma1 homolog", "gene_name": "Pnma1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAMTLLEDWCRGMDVNSQRALLVWGIPVNCDETEIEETLQAAMPQVSYRVLGRMFWREENAKAALLELTGTVDYSLIPREMPGKGGLWKVVFKPPTSDAEFLERLHLFLAREGWTVQDVARVLGFQNPAPAPGPEMPAEMLNYILDNVIQPLVESIWYKKLTLFSGRDIPGPGEETFDSWLEHSNEVIEEWQVSDIEKRRRLMESLRGPAADVIRILKTNNPAITTAECLKALEQVFGSVESSRDAQVRFLNTYQNPGEKLSSYVIRLEPLLQKVVDKGAIDKDNVNQARLEQVIAGANHSGALRRQLWLTGATEGPAPNLFQLLVQIREEEAKEEEEEAEAALLQLGLEGHF", "length": 353 }, "evidence": [ { "id": "A6QLK5", "url": "https://omabrowser.org/oma/group/A6QLK5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A6QLK5", "url": "https://www.uniprot.org/uniprotkb/A6QLK5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A6QLK5", "url": "https://www.uniprot.org/uniprotkb/A6QLK5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "inflammatory response to antigenic stimulus", "id": "GO:0002437", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002437", "evidence": [ { "database": "UniProtKB", "id": "A6QLK5", "url": "https://www.uniprot.org/uniprotkb/A6QLK5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 299, "end_pos": 301, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QLK5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 353, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QLK5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QLK5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 }, { "start_pos": 299, "end_pos": 301 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QLU7-1", "uniprot_ac": "A6QLU7", "uniprot_id": "TCAF2_BOVIN", "mass": { "chemical_mass": 99893.0, "monoisotopic_mass": 99893.0 }, "refseq": { "ac": "NP_001095394", "name": "TRPM8 channel-associated factor 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095394" }, "gene_names": [ { "name": "TCAF2", "type": "recommended", "evidence": [ { "id": "A6QLU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLU7" } ] }, { "name": "FAM115C", "type": "synonym", "evidence": [ { "id": "NP_001095394", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095394" }, { "id": "A6QLU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLU7" } ] }, { "name": "FAM139A", "type": "synonym", "evidence": [ { "id": "A6QLU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLU7" } ] }, { "name": "TCAF2", "type": "synonym", "evidence": [ { "id": "NP_001095394", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095394" } ] } ], "protein_names": [ { "name": "TRPM8 channel-associated factor 2", "type": "recommended", "evidence": [ { "id": "A6QLU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLU7/entry#names_and_taxonomy" } ] }, { "name": "TRP channel-associated factor 2", "type": "synonym", "evidence": [ { "id": "NP_001095394", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095394" }, { "id": "A6QLU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLU7/entry#names_and_taxonomy" } ] }, { "name": "TRPM8 channel-associated factor 2", "type": "synonym", "evidence": [ { "id": "NP_001095394", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095394" } ] }, { "name": "family with sequence similarity 115, member C", "type": "synonym", "evidence": [ { "id": "NP_001095394", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095394" } ] }, { "name": "protein FAM115C", "type": "synonym", "evidence": [ { "id": "NP_001095394", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095394" } ] } ], "function": [ { "annotation": "Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner.", "evidence": [ { "database": "UniProtKB", "id": "A6QLU7", "url": "https://www.uniprot.org/uniprotkb/A6QLU7#function" }, { "database": "UniProtKB", "id": "A6NFQ2", "url": "https://www.uniprot.org/uniprotkb/A6NFQ2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QLU7", "url": "https://www.uniprot.org/uniprotkb/A6QLU7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TCAF2", "url": "https://www.uniprot.org/uniprotkb/A6QLU7", "locus": { "chromosome": "4", "start_pos": 106983187, "end_pos": 106998346, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005475", "url": "https://www.ensembl.org/id/ENSBTAG00000005475" } ] } } ], "crossref": [ { "id": "A6QLU7", "url": "https://alphafold.ebi.ac.uk/entry/A6QLU7", "database": "AlphaFoldDB", "categories": [] }, { "id": "510320", "url": "https://www.ncbi.nlm.nih.gov/gene/510320", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029062", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029062", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035423", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035423", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042279", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042279", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051244", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051244", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510320", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510320", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A6QLU7", "url": "https://www.orthodb.org/?gene=A6QLU7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15730", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15730", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15730:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15730:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13402", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13402", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17291", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17291", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27016", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27016", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27027", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27027", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095394", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QLU7", "url": "https://www.uniprot.org/uniprotkb/A6QLU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QLU7-1", "url": "https://www.uniprot.org/uniprotkb/A6QLU7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATTPAAAFEALMDGVTSWELPEGPVPSELLLTGEAAFPVMVNDKGQVLIAASFYGRGRLVVVSHEGYLLDAGLARFLLNAVRWLSPSPGAPVGVHPSLASLAHILEGSGVEAQVHPEPAEPLGVYCISAYNDTMTAELIQFVKRGGGLLIGGQAWHWASQHGSDQVLSEFPGNQVTSVAGVYFTDTYGVKGRFKVSKKVPKIPLQVRCGEDLRQDQQQLLEGISELDIGTKGLPSQLLVHGALAFPLGLDASLRCFLAAARYGRGRVVLAAHEGMLSAPSLGPFLLNAVRWLAKGQTGKVGVNTSLEKLHTLLLEHGLECSLEPHLTSGVCVYCCTAYSDKEAKQLQEFVAEGGGLLIGGHAWWWASQNPGRSALADFPGNVILNSFGLSILPWTLDPGCFPVPSADSLNYHFRKALSEFQATLNLEGGNLEKNWLAKLRVDGAAFLQIPAEGVPAYASLHRLLRKQLRLRLSGFPAVSRENPVAGDSCEAVVLCLATELARSGTDCSELAQGLGAWSCSSNLCPSEHTVEINARNPSDDAWMSTGLNLPNGQLTEVCLCEAAACAGLKLQIGCHTDNLMSASKLSRAPVVTHQCHMDRTEQLVSNLWGGLLYVIVPTGCNLGPMSITIKRAVPAPYYKLGETSLEAWRSCIQESPAPWGELATDNIILTVPTADLRALEDPEPLLRLWDEMMEAIARLAAQPFPFRRPERIVADVQISAGWMHSGYPIMCHLESVSELIDETGMRSRGLWGPVHELGHNQQREQWEFPPHTTEATCNLWSVYVHETVLGIPRAQAHPALSPPERENRIKTHLEKGAPLCDWKVWTALETYLQLQEAFGWEPFTQLFAEYQTLSDIPNDNPGKMNLWVRKFSEKVQKNLAPFFEAWGWPVEKEVASSLACLPEWEENPMRMYI", "length": 914, "header": "sp|A6QLU7-1|TCAF2_BOVIN Isoform 1 of TRPM8 channel-associated factor 2 OS=Bos taurus OX=9913 GN=TCAF2 PE=2 SV=1 CANONICAL=A6QLU7-1" }, "isoforms": [ { "isoform_ac": "A6QLU7-1", "url": "https://www.uniprot.org/uniprotkb/A6QLU7/entry#A6QLU7-1", "sequence": { "sequence": "MATTPAAAFEALMDGVTSWELPEGPVPSELLLTGEAAFPVMVNDKGQVLIAASFYGRGRLVVVSHEGYLLDAGLARFLLNAVRWLSPSPGAPVGVHPSLASLAHILEGSGVEAQVHPEPAEPLGVYCISAYNDTMTAELIQFVKRGGGLLIGGQAWHWASQHGSDQVLSEFPGNQVTSVAGVYFTDTYGVKGRFKVSKKVPKIPLQVRCGEDLRQDQQQLLEGISELDIGTKGLPSQLLVHGALAFPLGLDASLRCFLAAARYGRGRVVLAAHEGMLSAPSLGPFLLNAVRWLAKGQTGKVGVNTSLEKLHTLLLEHGLECSLEPHLTSGVCVYCCTAYSDKEAKQLQEFVAEGGGLLIGGHAWWWASQNPGRSALADFPGNVILNSFGLSILPWTLDPGCFPVPSADSLNYHFRKALSEFQATLNLEGGNLEKNWLAKLRVDGAAFLQIPAEGVPAYASLHRLLRKQLRLRLSGFPAVSRENPVAGDSCEAVVLCLATELARSGTDCSELAQGLGAWSCSSNLCPSEHTVEINARNPSDDAWMSTGLNLPNGQLTEVCLCEAAACAGLKLQIGCHTDNLMSASKLSRAPVVTHQCHMDRTEQLVSNLWGGLLYVIVPTGCNLGPMSITIKRAVPAPYYKLGETSLEAWRSCIQESPAPWGELATDNIILTVPTADLRALEDPEPLLRLWDEMMEAIARLAAQPFPFRRPERIVADVQISAGWMHSGYPIMCHLESVSELIDETGMRSRGLWGPVHELGHNQQREQWEFPPHTTEATCNLWSVYVHETVLGIPRAQAHPALSPPERENRIKTHLEKGAPLCDWKVWTALETYLQLQEAFGWEPFTQLFAEYQTLSDIPNDNPGKMNLWVRKFSEKVQKNLAPFFEAWGWPVEKEVASSLACLPEWEENPMRMYI", "length": 914, "header": "sp|A6QLU7-1|TCAF2_BOVIN Isoform 1 of TRPM8 channel-associated factor 2 OS=Bos taurus OX=9913 GN=TCAF2 PE=2 SV=1 CANONICAL=A6QLU7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510320", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510320", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A6QLU7", "url": "https://www.uniprot.org/uniprotkb/A6QLU7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "A6QLU7", "url": "https://www.uniprot.org/uniprotkb/A6QLU7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of protein targeting to membrane", "id": "GO:0090314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090314", "evidence": [ { "database": "UniProtKB", "id": "A6QLU7", "url": "https://www.uniprot.org/uniprotkb/A6QLU7" } ], "pmid": "" }, { "name": "negative regulation of anion channel activity", "id": "GO:0010360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010360", "evidence": [ { "database": "UniProtKB", "id": "A6QLU7", "url": "https://www.uniprot.org/uniprotkb/A6QLU7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" }, { "start_pos": 304, "end_pos": 306, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QLU7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 914, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QLU7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QLU7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A6QLU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLU7" }, { "id": "PRU01060", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01060" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase M60", "eco_id": "ECO_0000255", "start_pos": 541, "end_pos": 840, "start_aa": "Asp", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 132, "end_pos": 134 }, { "start_pos": 304, "end_pos": 306 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QLY2-1", "uniprot_ac": "A6QLY2", "uniprot_id": "GPX7_BOVIN", "mass": { "chemical_mass": 20908.0, "monoisotopic_mass": 20908.0 }, "refseq": { "ac": "NP_001094583", "name": "glutathione peroxidase 7 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094583" }, "gene_names": [ { "name": "GPX7", "type": "recommended", "evidence": [ { "id": "A6QLY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLY2" } ] }, { "name": "GPX7", "type": "synonym", "evidence": [ { "id": "NP_001094583", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094583" } ] } ], "protein_names": [ { "name": "Protein peroxidase GPX7", "type": "recommended", "evidence": [ { "id": "A6QLY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLY2/entry#names_and_taxonomy" } ] }, { "name": "5.3.4.1", "type": "synonym", "evidence": [ { "id": "A6QLY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLY2/entry#names_and_taxonomy" } ] }, { "name": "GPx-7", "type": "synonym", "evidence": [ { "id": "NP_001094583", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094583" }, { "id": "A6QLY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLY2/entry#names_and_taxonomy" } ] }, { "name": "GSHPx-7", "type": "synonym", "evidence": [ { "id": "NP_001094583", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094583" }, { "id": "A6QLY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLY2/entry#names_and_taxonomy" } ] }, { "name": "glutathione peroxidase 7 precursor", "type": "synonym", "evidence": [ { "id": "NP_001094583", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094583" } ] } ], "function": [ { "annotation": "Acts as an endoplasmic reticulum (ER) thiol peroxidase that maintains ER redox homeostasis and supports oxidative protein folding. Rapidly reacts with hydrogen peroxide to form sulfenylated/disulfide intermediates and oxidizes protein disulfide isomerase (PDI) family members, promoting disulfide-bond formation. Functions in a redox relay with ERO1A, using ERO1A-generated H(2)O(2) to drive PDI oxidation, linking peroxide detoxification to productive disulfide formation. Protects esophageal epithelia from hydrogen peroxide-induced oxidative stress by reducing reactive oxygen species (ROS) and preventing oxidative DNA damage and double-strand breaks.", "evidence": [ { "database": "UniProtKB", "id": "A6QLY2", "url": "https://www.uniprot.org/uniprotkb/A6QLY2#function" }, { "database": "UniProtKB", "id": "Q96SL4", "url": "https://www.uniprot.org/uniprotkb/Q96SL4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QLY2", "url": "https://www.uniprot.org/uniprotkb/A6QLY2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPX7", "url": "https://www.uniprot.org/uniprotkb/A6QLY2", "locus": { "chromosome": "3", "start_pos": 93741612, "end_pos": 93749916, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018281", "url": "https://www.ensembl.org/id/ENSBTAG00000018281" } ] } } ], "crossref": [ { "id": "A6QLY2", "url": "https://alphafold.ebi.ac.uk/entry/A6QLY2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018281", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018281", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00340", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00340", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523311", "url": "https://www.ncbi.nlm.nih.gov/gene/523311", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000889", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013376", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013376", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029759", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029759", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029760", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523311", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523311", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QCGLTKQ", "url": "https://omabrowser.org/oma/group/QCGLTKQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QLY2", "url": "https://www.orthodb.org/?gene=A6QLY2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11592", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11592", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11592:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11592:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00255", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00255", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3299685", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3299685", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001094583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094583", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QLY2", "url": "https://www.uniprot.org/uniprotkb/A6QLY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QLY2-1", "url": "https://www.uniprot.org/uniprotkb/A6QLY2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVAARAAAWLLLAAAACAPREQDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFTDQHYRALQQLQRDLGPHHFNVLAFPCNQFGQQEPDSNKEIESFARRTYSVSFPMFSKIAVTGTGAHPAFKYLTETSGKEPTWNFWKYLVAPDGKVIGAWDPTVSVEEIRPQITALVRKLILKKREDL", "length": 186, "header": "sp|A6QLY2-1|GPX7_BOVIN Isoform 1 of Protein peroxidase GPX7 OS=Bos taurus OX=9913 GN=GPX7 PE=2 SV=1 CANONICAL=A6QLY2-1" }, "isoforms": [ { "isoform_ac": "A6QLY2-1", "url": "https://www.uniprot.org/uniprotkb/A6QLY2/entry#A6QLY2-1", "sequence": { "sequence": "MVAARAAAWLLLAAAACAPREQDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFTDQHYRALQQLQRDLGPHHFNVLAFPCNQFGQQEPDSNKEIESFARRTYSVSFPMFSKIAVTGTGAHPAFKYLTETSGKEPTWNFWKYLVAPDGKVIGAWDPTVSVEEIRPQITALVRKLILKKREDL", "length": 186, "header": "sp|A6QLY2-1|GPX7_BOVIN Isoform 1 of Protein peroxidase GPX7 OS=Bos taurus OX=9913 GN=GPX7 PE=2 SV=1 CANONICAL=A6QLY2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:523311", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523311", "resource": "KEGG Pathway" }, { "id": "R-BTA-3299685", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3299685", "resource": "Reactome", "description": "Detoxification of Reactive Oxygen Species" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6ARN0-1", "protein_name": "Glutathione peroxidase", "gene_name": "Gpx7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVAAVATAWLLLWAAACTQSEQDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFTDQNYRALQQLQRDLGPYHFNVLAFPCNQFGQQEPDSNREIENFARRTYSVSFPMFSKIAVTGTGAHPAFKYLTQTSGKEPTWNFWKYLVAPDGKVVGAWDPTVPVEEIKPRITEQKTSLRSQQTPPPSSSPLPSSQGRSPALDQRLHLPLCPGLHSTRRAPHSVLQLPRGSWMPKSLRI", "length": 238 }, "evidence": [ { "id": "A6QLY2", "url": "https://omabrowser.org/oma/group/A6QLY2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3GW03-1", "protein_name": "Glutathione peroxidase", "gene_name": "Gpx7", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVATVAAAWLLLWATACAKSEQDFYDFKAVNIRGKLVSLDKYRGSVSLVVNVASECGFTDQNYRALQQLQRDLGPYHFNVLAFPCNQFGQQEPDTNREIENFARRTYSVSFPMFSKIAVTGTGAHPAFKYLTQTSGKEPTWNFWKYLVDPDGKVVGAWDPTVPIQEIKPQITELMVKLILKKREEL", "length": 186 }, "evidence": [ { "id": "A6QLY2", "url": "https://omabrowser.org/oma/group/A6QLY2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O04922-1", "protein_name": "Probable glutathione peroxidase 2", "gene_name": "GPX2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MADESPKSIYDFTVKDIGGNDVSLDQYKGKTLLVVNVASKCGLTDANYKELNVLYEKYKEQGLEILAFPCNQFLGQEPGNNEEIQQTVCTRFKAEFPIFDKVDVNGKNTAPLYKYLKAEKGGLLIDAIKWNFTKFLVSPDGKVLQRYSPRTSPLQFEKDIQTALGQASS", "length": 169 }, "evidence": [ { "id": "A6QLY2", "url": "https://omabrowser.org/oma/group/A6QLY2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P38143-1", "protein_name": "Glutathione peroxidase-like peroxiredoxin 2", "gene_name": "GPX2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTTSFYDLECKDKKGESFKFDQLKGKVVLIVNVASKCGFTPQYKELEELYKKYQDKGFVILGFPCNQFGKQEPGSDEQITEFCQLNYGVTFPIMKKIDVNGSNADSVYNYLKSQKAGLLGFKGIKWNFEKFLVDSNGKVVQRFSSLTKPSSLDQEIQSLLSK", "length": 162 }, "evidence": [ { "id": "A6QLY2", "url": "https://omabrowser.org/oma/group/A6QLY2/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q96SL4-1", "protein_name": "Protein peroxidase GPX7", "gene_name": "GPX7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVAATVAAAWLLLWAAACAQQEQDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFTDQHYRALQQLQRDLGPHHFNVLAFPCNQFGQQEPDSNKEIESFARRTYSVSFPMFSKIAVTGTGAHPAFKYLAQTSGKEPTWNFWKYLVAPDGKVVGAWDPTVSVEEVRPQITALVRKLILLKREDL", "length": 187 }, "evidence": [ { "id": "A6QLY2", "url": "https://omabrowser.org/oma/group/A6QLY2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99LJ6-1", "protein_name": "Protein peroxidase GPX7", "gene_name": "Gpx7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVAAVATAWLLLWAAACAQSEQDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFTDQNYRALQQLQRDLGPHHFNVLAFPCNQFGQQEPDTNREIENFARRTYSVSFPMFSKIAVTGTGAHPAFKYLTQTSGKEPTWNFWKYLVDPDGKVVGAWDPTVPVAEIKPRITEQVMKLILRKREDL", "length": 186 }, "evidence": [ { "id": "A6QLY2", "url": "https://omabrowser.org/oma/group/A6QLY2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A6QLY2", "url": "https://www.uniprot.org/uniprotkb/A6QLY2" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A6QLY2", "url": "https://www.uniprot.org/uniprotkb/A6QLY2" } ], "pmid": "" }, { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "A6QLY2", "url": "https://www.uniprot.org/uniprotkb/A6QLY2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cellular response to oxidative stress", "id": "GO:0034599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034599", "evidence": [ { "database": "UniProtKB", "id": "A6QLY2", "url": "https://www.uniprot.org/uniprotkb/A6QLY2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "peroxidase activity", "id": "GO:0004601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004601", "evidence": [ { "database": "UniProtKB", "id": "A6QLY2", "url": "https://www.uniprot.org/uniprotkb/A6QLY2" } ], "pmid": "" }, { "name": "glutathione peroxidase activity", "id": "GO:0004602", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004602", "evidence": [ { "database": "UniProtKB", "id": "A6QLY2", "url": "https://www.uniprot.org/uniprotkb/A6QLY2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-3341296", "name": "GPX7,8 catalyze peroxidation of P4HB (PDI)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum lumen", "input_participant_list": [ "R-ALL-3341383", "R-BTA-174692" ], "output_participant_list": [], "enzyme_list": [ "Q2NL01-1", "A5PJN2-1", "F6Q9Q9-1", "A6QLY2-1" ], "evidence": [ { "id": "R-BTA-3341296", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3341296" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-3341383", "participant_name": "H2O2 [endoplasmic reticulum lumen]", "crossref": [ { "id": "16240", "database": "ChEBI", "url": "" }, { "id": "C00027", "database": "COMPOUND", "url": "" }, { "id": "11533079", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0003125", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-BTA-174692", "participant_name": "P4HB [endoplasmic reticulum lumen]", "crossref": [ { "id": "F6Q9Q9", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000006045", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000007943", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000007943", "database": "ENSEMBL", "url": "" }, { "id": "32538", "database": "VGNC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A5PJN2", "gene_name": "ERO1A", "activity": [ { "ec_number": "1.8.3.2", "activity": "2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.", "evidence": [ { "id": "A5PJN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJN2" } ] }, { "ec_number": "1.8.3.2", "activity": "", "evidence": [ { "id": "A5PJN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJN2" } ] } ] }, { "uniprot_ac": "A6QLY2", "gene_name": "GPX7", "activity": [ { "ec_number": "5.3.4.1", "activity": "Catalyzes the rearrangement of -S-S- bonds in proteins.", "evidence": [ { "id": "A6QLY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLY2" } ] }, { "ec_number": "5.3.4.1", "activity": "", "evidence": [ { "id": "A6QLY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLY2" } ] } ] }, { "uniprot_ac": "F6Q9Q9", "gene_name": "P4HB", "activity": [ { "ec_number": "5.3.4.1", "activity": "Catalyzes the rearrangement of -S-S- bonds in proteins.", "evidence": [ { "id": "F6Q9Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9Q9" } ] }, { "ec_number": "5.3.4.1", "activity": "", "evidence": [ { "id": "F6Q9Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9Q9" } ] } ] }, { "uniprot_ac": "Q2NL01", "gene_name": "GPX8", "activity": [ { "ec_number": "5.3.4.1", "activity": "Catalyzes the rearrangement of -S-S- bonds in proteins.", "evidence": [ { "id": "Q2NL01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL01" } ] }, { "ec_number": "5.3.4.1", "activity": "", "evidence": [ { "id": "Q2NL01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL01" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QLY2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 186, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QLY2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QLY2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "5.3.4.1", "ec_name": "Catalyzes the rearrangement of -S-S- bonds in proteins.", "evidence": [ { "id": "5.3.4.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=5.3.4.1" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QNP3-1", "uniprot_ac": "A6QNP3", "uniprot_id": "PPR3B_BOVIN", "mass": { "chemical_mass": 32383.0, "monoisotopic_mass": 32383.0 }, "refseq": { "ac": "NP_001096717", "name": "protein phosphatase 1 regulatory subunit 3B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096717" }, "gene_names": [ { "name": "PPP1R3B", "type": "recommended", "evidence": [ { "id": "A6QNP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNP3" } ] }, { "name": "PPP1R3B", "type": "synonym", "evidence": [ { "id": "NP_001096717", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096717" } ] } ], "protein_names": [ { "name": "Protein phosphatase 1 regulatory subunit 3B", "type": "recommended", "evidence": [ { "id": "A6QNP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNP3/entry#names_and_taxonomy" } ] }, { "name": "protein phosphatase 1 regulatory subunit 3B", "type": "synonym", "evidence": [ { "id": "NP_001096717", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096717" } ] }, { "name": "protein phosphatase 1, regulatory (inhibitor) subunit 3B", "type": "synonym", "evidence": [ { "id": "NP_001096717", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096717" } ] } ], "function": [ { "annotation": "Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A6QNP3", "url": "https://www.uniprot.org/uniprotkb/A6QNP3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QNP3", "url": "https://www.uniprot.org/uniprotkb/A6QNP3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPP1R3B", "url": "https://www.uniprot.org/uniprotkb/A6QNP3", "locus": { "chromosome": "27", "start_pos": 25176089, "end_pos": 25190804, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010606", "url": "https://www.ensembl.org/id/ENSBTAG00000010606" } ] } } ], "crossref": [ { "id": "A6QNP3", "url": "https://alphafold.ebi.ac.uk/entry/A6QNP3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010606", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010606", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22814", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22814", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514428", "url": "https://www.ncbi.nlm.nih.gov/gene/514428", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017434", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017434", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030682", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030682", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038175", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038175", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050782", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050782", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514428", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514428", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A6QNP3", "url": "https://www.orthodb.org/?gene=A6QNP3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12307", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12307", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12307:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12307:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03370", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03370", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001096717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096717", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QNP3", "url": "https://www.uniprot.org/uniprotkb/A6QNP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QNP3-1", "url": "https://www.uniprot.org/uniprotkb/A6QNP3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVDIECRYSCMAPSLRRERFAFQIAPKPSKPLRPCIQLSGKNEASGTVAPTVQEKKVKKRVSFADNQGLALTMVKVFSEFDDPLDIPLNITELLDSIVSLTTAESESFVLDFSQPSADYLDFRNRLQTDHVCLENCVLKDRSIAGTVKVQNLAFEKTVKVRMTFDTWKSFTDFPCWYVKDTYAGSDKDTFSFDISLPEKIQSYERMEFAVCYECNGQTYWDSNKGKNYRIIRAELQSTQGTAQPPNGPDFEIAFDQFGSPRCSYGLFPEWPSYLGYEKLGPYY", "length": 284, "header": "sp|A6QNP3-1|PPR3B_BOVIN Isoform 1 of Protein phosphatase 1 regulatory subunit 3B OS=Bos taurus OX=9913 GN=PPP1R3B PE=2 SV=1 CANONICAL=A6QNP3-1" }, "isoforms": [ { "isoform_ac": "A6QNP3-1", "url": "https://www.uniprot.org/uniprotkb/A6QNP3/entry#A6QNP3-1", "sequence": { "sequence": "MAVDIECRYSCMAPSLRRERFAFQIAPKPSKPLRPCIQLSGKNEASGTVAPTVQEKKVKKRVSFADNQGLALTMVKVFSEFDDPLDIPLNITELLDSIVSLTTAESESFVLDFSQPSADYLDFRNRLQTDHVCLENCVLKDRSIAGTVKVQNLAFEKTVKVRMTFDTWKSFTDFPCWYVKDTYAGSDKDTFSFDISLPEKIQSYERMEFAVCYECNGQTYWDSNKGKNYRIIRAELQSTQGTAQPPNGPDFEIAFDQFGSPRCSYGLFPEWPSYLGYEKLGPYY", "length": 284, "header": "sp|A6QNP3-1|PPR3B_BOVIN Isoform 1 of Protein phosphatase 1 regulatory subunit 3B OS=Bos taurus OX=9913 GN=PPP1R3B PE=2 SV=1 CANONICAL=A6QNP3-1" }, "locus": { "chromosome": "27", "start_pos": 25183032, "end_pos": 25182181, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120296.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120296.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094109.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094109.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 260, "end_pos": 260, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A6QNP3", "url": "https://www.uniprot.org/uniprotkb/A6QNP3" } ], "site_lbl": "Ser260" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514428", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514428", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XFB6-1", "protein_name": "Protein phosphatase 1 regulatory subunit", "gene_name": "PPP1R3B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAVDVAMQLYLCSSPLRRERCACKIAPKPNKPLRPCIQLNSKAVLTGPEEAENSFTHNKVKKKVSFADSRGFALTMVKVFSEFDDPLDIPFNISELIDNIVSLTTVERDSFVLDFVQPSADYLDFRNRLQTDCVCLENCMLKERSVVGTVKVRNLAFEKSVRIRMTFDTWKNFVDYPCQYVKDTYGGSDRDTFSFDISLPDGIQSHERVEFAISFECNGKVYWDSNKGTNYRIIRSELKSAQEALRPPCSPDFSSAFDQFGSPRCAYGLFAEWPSYSGYEKLGPYY", "length": 286 }, "evidence": [ { "id": "A6QNP3", "url": "https://omabrowser.org/oma/group/A6QNP3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3H0H2-1", "protein_name": "Protein phosphatase 1 regulatory subunit", "gene_name": "Ppp1r3b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAVDIEYSYSSMAPSLRRERFTFKISPKLNKPLRPCIQLGSKDEASGMVAPTVQEKKVKKRVSFADNQGLALTMVKVFSEFDDPLDIPFNITELLDNIVSLTTAESESFVLDFPQPSADYLDFRNRLQANHVCLENCVLKDKAIAGTVKVQNLAFEKVVKIRMTFDTWKSFTDFPCQYVKDTYAGSDRDTFSFDISLPEKIQSYERMEFAVCYECNGQSYWDSNKGKNYRIIRAELQSAQGMTEPYNGPDFGISFDQFGSPRCSYGLFPEWPSYLGYEKLGPYY", "length": 284 }, "evidence": [ { "id": "A6QNP3", "url": "https://omabrowser.org/oma/group/A6QNP3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3L6I5-1", "protein_name": "Protein phosphatase 1 regulatory subunit", "gene_name": "PPP1R3B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAVDIECRYSCMAPSLRRERFTFQISPKPSKPLRPCIQLSSKNEASGTVAPTVQEKKVKKRVSFADNQGLALTMVKVFSEFDDPLDIPLNITELLDNIVSLTTAESESFVLDFAQPSADYLDFRNRLQTDHVCLENCVLKDRAIEGTVKVQNLAFEKMVKVRMTFDTWKSFTDFPCWYVKDTYAGSDRDTFSFDISLPEKIQSYERMEFAVCYECNGQTYWDSNKGKNYRIIRAELKSTQGTAQPQNGPDFGIALDQFGSPRCSYGLFPEWPSYLGYEKLGPYY", "length": 284 }, "evidence": [ { "id": "A6QNP3", "url": "https://omabrowser.org/oma/group/A6QNP3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6IN01-1", "protein_name": "Protein phosphatase 1 regulatory subunit 3B", "gene_name": "Ppp1r3b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAVDIEYSYSSMAPSLRRERFTFKISPKLNKPLRPCIQLGSKDEAGRMVAPTVQEKKVKKRVSFADNQGLALTMVKVFSEFDDPLDIPFNITELLDNIVSLTTAESESFVLDFPQPSADYLDFRNRLQTNHVCLENCVLKEKAIAGTVKVQNLAFEKVVKIRMTFDTWKSFTDFPCQYVKDTYAGSDRDTFSFDISLPEKIQSYERMEFAVCYECNGQSYWDSNKGKNYRITRAELRSTQGMTEPYNGPDFGISFDQFGSPRCSFGLFPEWPSYLGYEKLGPYY", "length": 284 }, "evidence": [ { "id": "A6QNP3", "url": "https://omabrowser.org/oma/group/A6QNP3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q803M0-1", "protein_name": "Protein phosphatase 1 regulatory subunit 3B", "gene_name": "ppp1r3b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPIELAMSLYLSSDEFLNPRASKYSRPLQPCLNQCKSSKLSFSSLKEQSEFNGVSRALMIPGRAKKHVSFADHKGLALTVVKIFSEFDDPIDIPDNIDNFFTSSLTVSEGKDKLTLDFDQPSADYLKFRQRIENDHVCLEHCMLKEKSIMGTVKVKNISFEKSVKLRITFNTWKNHTDVECQYVKDTYTGSNRDTFSFEASLPEQVPSHERIEFAICYEVNGDTLWDNNQGKNYRIIQSALRKSSNESNGGHQQYSQSDWDIHFDRYGSPRCSRGIFPHWPSYVGYEDIGPYY", "length": 293 }, "evidence": [ { "id": "A6QNP3", "url": "https://omabrowser.org/oma/group/A6QNP3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q86XI6-1", "protein_name": "Protein phosphatase 1 regulatory subunit 3B", "gene_name": "PPP1R3B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMAVDIEYRYNCMAPSLRQERFAFKISPKPSKPLRPCIQLSSKNEASGMVAPAVQEKKVKKRVSFADNQGLALTMVKVFSEFDDPLDMPFNITELLDNIVSLTTAESESFVLDFSQPSADYLDFRNRLQADHVCLENCVLKDKAIAGTVKVQNLAFEKTVKIRMTFDTWKSYTDFPCQYVKDTYAGSDRDTFSFDISLPEKIQSYERMEFAVYYECNGQTYWDSNRGKNYRIIRAELKSTQGMTKPHSGPDLGISFDQFGSPRCSYGLFPEWPSYLGYEKLGPYY", "length": 285 }, "evidence": [ { "id": "A6QNP3", "url": "https://omabrowser.org/oma/group/A6QNP3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C767-1", "protein_name": "Protein phosphatase 1 regulatory subunit 3B", "gene_name": "Ppp1r3b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAVDIQYSYSSMAPSLRRERFTFKISPKLSKPLRPCIQLGSKDEASGMVAPAVQEKKVKKRVSFADNQGLALTMVKVFSEFDDPLDIPFNITELLDNIVSLTTAESESFVLDFPQPSADYLDFRNRLQTNHVCLENCVLKDKAIAGTVKVQNLAFEKVVKIRMTFDTWKSFTDFPCQYVKDTYAGSDRDTFSFDISLPEKIQSYERMEFAVCYECNGQAYWDSNKGKNYRITRAELRSSPGKIEPYNGPDFGISFDQFGSPRCSFGLFPEWPSYLGYEKLGPYY", "length": 284 }, "evidence": [ { "id": "A6QNP3", "url": "https://omabrowser.org/oma/group/A6QNP3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "protein phosphatase type 1 complex", "id": "GO:0000164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000164", "evidence": [ { "database": "UniProtKB", "id": "A6QNP3", "url": "https://www.uniprot.org/uniprotkb/A6QNP3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of glycogen catabolic process", "id": "GO:0045818", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045818", "evidence": [ { "database": "UniProtKB", "id": "A6QNP3", "url": "https://www.uniprot.org/uniprotkb/A6QNP3" } ], "pmid": "" }, { "name": "glycogen metabolic process", "id": "GO:0005977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005977", "evidence": [ { "database": "UniProtKB", "id": "A6QNP3", "url": "https://www.uniprot.org/uniprotkb/A6QNP3" } ], "pmid": "" }, { "name": "positive regulation of glycogen biosynthetic process", "id": "GO:0045725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045725", "evidence": [ { "database": "UniProtKB", "id": "A6QNP3", "url": "https://www.uniprot.org/uniprotkb/A6QNP3" } ], "pmid": "" }, { "name": "regulation of glycogen biosynthetic process", "id": "GO:0005979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005979", "evidence": [ { "database": "UniProtKB", "id": "A6QNP3", "url": "https://www.uniprot.org/uniprotkb/A6QNP3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein phosphatase regulator activity", "id": "GO:0019888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019888", "evidence": [ { "database": "UniProtKB", "id": "A6QNP3", "url": "https://www.uniprot.org/uniprotkb/A6QNP3" } ], "pmid": "" }, { "name": "protein phosphatase 1 binding", "id": "GO:0008157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008157", "evidence": [ { "database": "UniProtKB", "id": "A6QNP3", "url": "https://www.uniprot.org/uniprotkb/A6QNP3" } ], "pmid": "" }, { "name": "glycogen binding", "id": "GO:2001069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001069", "evidence": [ { "database": "UniProtKB", "id": "A6QNP3", "url": "https://www.uniprot.org/uniprotkb/A6QNP3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QNP3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 284, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QNP3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QNP3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A6QNP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNP3" }, { "id": "PRU00491", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00491" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CBM21", "eco_id": "ECO_0000255", "start_pos": 124, "end_pos": 232, "start_aa": "Arg", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 260 ], "sequon_annotation_sites": [ { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QNU9-1", "uniprot_ac": "A6QNU9", "uniprot_id": "PLCX3_BOVIN", "mass": { "chemical_mass": 36357.0, "monoisotopic_mass": 36357.0 }, "refseq": { "ac": "NP_001096774", "name": "PI-PLC X domain-containing protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096774" }, "gene_names": [ { "name": "PLCXD3", "type": "recommended", "evidence": [ { "id": "A6QNU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNU9" } ] }, { "name": "PLCXD3", "type": "synonym", "evidence": [ { "id": "NP_001096774", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096774" } ] } ], "protein_names": [ { "name": "PI-PLC X domain-containing protein 3", "type": "recommended", "evidence": [ { "id": "A6QNU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QNU9/entry#names_and_taxonomy" } ] }, { "name": "PI-PLC X domain-containing protein 3", "type": "synonym", "evidence": [ { "id": "NP_001096774", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096774" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QNU9", "url": "https://www.uniprot.org/uniprotkb/A6QNU9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLCXD3", "url": "https://www.uniprot.org/uniprotkb/A6QNU9", "locus": { "chromosome": "20", "start_pos": 33218726, "end_pos": 33016794, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010822", "url": "https://www.ensembl.org/id/ENSBTAG00000010822" } ] } } ], "crossref": [ { "id": "A6QNU9", "url": "https://alphafold.ebi.ac.uk/entry/A6QNU9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd08616", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08616", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "781239", "url": "https://www.ncbi.nlm.nih.gov/gene/781239", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017946", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017946", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042158", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042158", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:781239", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781239", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A6QNU9", "url": "https://www.orthodb.org/?gene=A6QNU9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13593", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13593", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13593:SF33", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13593:SF33", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00388", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00388", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001096774", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096774", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QNU9", "url": "https://www.uniprot.org/uniprotkb/A6QNU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QNU9-1", "url": "https://www.uniprot.org/uniprotkb/A6QNU9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASSQGKNELKFADWMATLPESIHSIPLTNLAIPGSHDSFSFYIDEASPVGPEQPETVQNFVSVFGTVAKKLMRKWLATQTMNFTGQLGAGIRYFDLRISTKPRDPDNELYFAHGLFSAKVNEGLEEINAFLTDHHKELVFLDFNHFYGMQKYHHEKLVQMLKDIYGNKMCPAIFAQEVSLKYLWEKDYQVLVFYHSPVALEVPFLWPGQMMPAPWANTTDPEKLIQFLQASITERRKKGSFFISQVVLTPKASTVVKGVASGLRETITERALPAMMQWVRTQKPGESGINIVTADFVELGDFISTVIKLNYVFEEGEANT", "length": 321, "header": "sp|A6QNU9-1|PLCX3_BOVIN Isoform 1 of PI-PLC X domain-containing protein 3 OS=Bos taurus OX=9913 GN=PLCXD3 PE=2 SV=1 CANONICAL=A6QNU9-1" }, "isoforms": [ { "isoform_ac": "A6QNU9-1", "url": "https://www.uniprot.org/uniprotkb/A6QNU9/entry#A6QNU9-1", "sequence": { "sequence": "MASSQGKNELKFADWMATLPESIHSIPLTNLAIPGSHDSFSFYIDEASPVGPEQPETVQNFVSVFGTVAKKLMRKWLATQTMNFTGQLGAGIRYFDLRISTKPRDPDNELYFAHGLFSAKVNEGLEEINAFLTDHHKELVFLDFNHFYGMQKYHHEKLVQMLKDIYGNKMCPAIFAQEVSLKYLWEKDYQVLVFYHSPVALEVPFLWPGQMMPAPWANTTDPEKLIQFLQASITERRKKGSFFISQVVLTPKASTVVKGVASGLRETITERALPAMMQWVRTQKPGESGINIVTADFVELGDFISTVIKLNYVFEEGEANT", "length": 321, "header": "sp|A6QNU9-1|PLCX3_BOVIN Isoform 1 of PI-PLC X domain-containing protein 3 OS=Bos taurus OX=9913 GN=PLCXD3 PE=2 SV=1 CANONICAL=A6QNU9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:781239", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781239", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A6QNU9", "url": "https://www.uniprot.org/uniprotkb/A6QNU9" } ], "pmid": "" }, { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "A6QNU9", "url": "https://www.uniprot.org/uniprotkb/A6QNU9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, 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"categories": [ "Protein Classification" ] }, { "id": "PTHR45716", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45716", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45716:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45716:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02318", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02318", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A6QP06", "url": "https://www.uniprot.org/uniprotkb/A6QP06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QP06-1", "url": "https://www.uniprot.org/uniprotkb/A6QP06-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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Isoform 1 of Synaptotagmin-like protein 2 OS=Bos taurus OX=9913 GN=SYTL2 PE=2 SV=1 CANONICAL=A6QP06-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614406", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614406", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A6QP06", "url": "https://www.uniprot.org/uniprotkb/A6QP06" } ], "pmid": "" }, { "name": "exocytic vesicle", "id": "GO:0070382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070382", "evidence": [ { "database": "UniProtKB", "id": "A6QP06", "url": "https://www.uniprot.org/uniprotkb/A6QP06" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "A6QP06", "url": "https://www.uniprot.org/uniprotkb/A6QP06" } ], "pmid": "" }, { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "A6QP06", "url": "https://www.uniprot.org/uniprotkb/A6QP06" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A6QP06", "url": "https://www.uniprot.org/uniprotkb/A6QP06" } ], "pmid": "" }, { "name": "neurexin family protein binding", "id": "GO:0042043", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042043", "evidence": [ { "database": "UniProtKB", "id": "A6QP06", "url": "https://www.uniprot.org/uniprotkb/A6QP06" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 367, "end_pos": 369, "annotation": "n_glycosylation_sequon" }, { "start_pos": 405, "end_pos": 407, "annotation": "n_glycosylation_sequon" }, { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" }, { "start_pos": 607, "end_pos": 609, "annotation": "n_glycosylation_sequon" }, { "start_pos": 724, "end_pos": 726, "annotation": "n_glycosylation_sequon" }, { "start_pos": 853, "end_pos": 855, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QP06-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 943, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": 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"sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QP35-1", "uniprot_ac": "A6QP35", "uniprot_id": "KR108_BOVIN", "mass": { "chemical_mass": 22549.0, "monoisotopic_mass": 22549.0 }, "refseq": { "ac": "NP_001094760", "name": "keratin-associated protein 10-8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094760" }, "gene_names": [ { "name": "KRTAP10-8", "type": "recommended", "evidence": [ { "id": "A6QP35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP35" } ] }, { "name": "KRTAP10-8", "type": "synonym", "evidence": [ { "id": "NP_001094760", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094760" } ] } ], "protein_names": [ { "name": "Keratin-associated protein 10-8", "type": "recommended", "evidence": [ { "id": "A6QP35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP35/entry#names_and_taxonomy" } ] }, { "name": "keratin-associated protein 10-8", "type": "synonym", "evidence": [ { "id": "NP_001094760", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094760" } ] } ], "function": [ { "annotation": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A6QP35", "url": "https://www.uniprot.org/uniprotkb/A6QP35#function" }, { "database": "UniProtKB", "id": "P60410", "url": "https://www.uniprot.org/uniprotkb/P60410#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QP35", "url": "https://www.uniprot.org/uniprotkb/A6QP35" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRTAP10-8", "url": "https://www.uniprot.org/uniprotkb/A6QP35", "locus": { "chromosome": "1", "start_pos": 144562673, "end_pos": 144560572, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040291", "url": "https://www.ensembl.org/id/ENSBTAG00000040291" } ] } } ], "crossref": [ { "id": "A6QP35", "url": "https://alphafold.ebi.ac.uk/entry/A6QP35", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040291", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040291", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "783679", "url": "https://www.ncbi.nlm.nih.gov/gene/783679", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002494", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002494", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:783679", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783679", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RCDPPCR", "url": "https://omabrowser.org/oma/group/RCDPPCR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QP35", "url": "https://www.orthodb.org/?gene=A6QP35", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23262", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23262", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23262:SF50", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23262:SF50", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13885", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13885", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6805567", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001094760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094760", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QP35", "url": "https://www.uniprot.org/uniprotkb/A6QP35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QP35-1", "url": "https://www.uniprot.org/uniprotkb/A6QP35-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADTCCSRTCVVAASTLSVCSSDLSCGNQVSSPSACIGSSWQVDDCQETCCEPTCCAPSCCAPAPRLTLICAPVNCESSPCCQPACSSSSPCQQACCVPVCCRPVCCTPVCCRPVCCRPVCCTPVCCRPVCCRPVCCRPVCCRPVCCTPVCCRPMCCEASPCSAPSSCCRPSSSVSLLCRPVCRPTCCVPTFFCQPSCCHPASSVSLLCQPSCSSSAC", "length": 218, "header": "sp|A6QP35-1|KR108_BOVIN Isoform 1 of Keratin-associated protein 10-8 OS=Bos taurus OX=9913 GN=KRTAP10-8 PE=2 SV=1 CANONICAL=A6QP35-1" }, "isoforms": [ { "isoform_ac": "A6QP35-1", "url": "https://www.uniprot.org/uniprotkb/A6QP35/entry#A6QP35-1", "sequence": { "sequence": "MADTCCSRTCVVAASTLSVCSSDLSCGNQVSSPSACIGSSWQVDDCQETCCEPTCCAPSCCAPAPRLTLICAPVNCESSPCCQPACSSSSPCQQACCVPVCCRPVCCTPVCCRPVCCRPVCCTPVCCRPVCCRPVCCRPVCCRPVCCTPVCCRPMCCEASPCSAPSSCCRPSSSVSLLCRPVCRPTCCVPTFFCQPSCCHPASSVSLLCQPSCSSSAC", "length": 218, "header": "sp|A6QP35-1|KR108_BOVIN Isoform 1 of Keratin-associated protein 10-8 OS=Bos taurus OX=9913 GN=KRTAP10-8 PE=2 SV=1 CANONICAL=A6QP35-1" }, "locus": { "chromosome": "1", "start_pos": 144561280, "end_pos": 144560627, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043652.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043652.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041209.3", "url": "https://www.ensembl.org/id/ENSBTAP00000041209.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:783679", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783679", "resource": "KEGG Pathway" }, { "id": "R-BTA-6805567", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "resource": "Reactome", "description": "Keratinization" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1W2P7T6-1", "protein_name": "Keratin associated protein 10-10", "gene_name": "Krtap10-10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAASTMSVCSDARTNSSWQVDDCPESCCEPCCCAPSCCQPSCCQPSCCQPSCCQPSCCAPAPCLTLICTPVSCVSSPCCQSSCCTPSCCQQSSCQPACCTCSPCQPSCCVPVCCTPVCCTPVCCTPVCCKPVCCTPICSGSSSSCCQPSCCAPVCCKPCSSLSLLCRPVCRPACCVPTSSCCASSCQPNCCRPASCVSLLCRPACSKQACCGQKSSC", "length": 217 }, "evidence": [ { "id": "A6QP35", "url": "https://omabrowser.org/oma/group/A6QP35/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZUP1-1", "protein_name": "Keratin associated protein 10-8 like 1", "gene_name": "Krtap10-8l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAASTMSVCSDACTNSSWQVDDCPESCCEPCGCAPSCCQPSCCVPLLCTPVSCVSSPCCQSSCCTPSCCQQSSCQPACCTCSPCQQSCGVTLCCKPVCCTPICSGSSSCCQQSSCQSSCCQPSCCVPVCCRPVCCTPICSASSSSCCQPSCCAPVCCKPVCCKPCSSLSLLCRPVCRPACCVPTSSCCASSCQPSCCRPASCVSLLCRPACSRQACSGQKSTC", "length": 223 }, "evidence": [ { "id": "A6QP35", "url": "https://omabrowser.org/oma/group/A6QP35/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LH42-1", "protein_name": "Uncharacterized protein", "gene_name": "LOC100622826", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAASTLSGCSSNLSYGSHVYLPGPCHPCTGSSWQWDDCPESCCEPPCCAPSGCTPAPRLALVCTPASCEPSPCLSGCTSSCTSSPCQPACCAPVCCRPVCCRPVCCTPVCCTPVCCTPVCCEASPCSASSCCQPSPCPCPSSCCRPSSSVSLLCRPMCRPACCVPVSSCGAPASCCQPSCCRPASCVSLLCRPACSRPACCVPASACESCC", "length": 211 }, "evidence": [ { "id": "A6QP35", "url": "https://omabrowser.org/oma/group/A6QP35/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P60411-1", "protein_name": "Keratin-associated protein 10-9", "gene_name": "KRTAP10-9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAASTMSIRSSAYSDSWQVDDCPESCCEPPCCATSCCAPAPCLTLVCTPVSRVSSPCCQVTCEPSPCQSGCTSSCTPSCCQQSSCQPAYCTSSPCQQACCVPVCCKPVCCVPVCCGASSCCQQSSYQPACCASSSCQPACCVPVCCKPVCCAPTCSEDSYSCCQQSSCQPACCTSSPCQQSYCVPVCCKPVCCKPICCVPVCSGASSLCCQQSGCQPACCTTSCCRPSSSVSLLCRPVCRPACCVPVSSCCAPTSSRQPSYCRQASCVSLLCRPVCSRPACYSFSSGQKSSC", "length": 292 }, "evidence": [ { "id": "A6QP35", "url": "https://omabrowser.org/oma/group/A6QP35/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A6QP35", "url": "https://www.uniprot.org/uniprotkb/A6QP35" } ], "pmid": "" }, { "name": "keratin filament", "id": "GO:0045095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045095", "evidence": [ { "database": "UniProtKB", "id": "A6QP35", "url": "https://www.uniprot.org/uniprotkb/A6QP35" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QP35-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 218, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QP35-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QP35" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { 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"uniprot_ac": "A6QP66", "uniprot_id": "RERGL_BOVIN", "mass": { "chemical_mass": 23371.0, "monoisotopic_mass": 23371.0 }, "refseq": { "ac": "NP_001098942", "name": "ras-related and estrogen-regulated growth inhibitor-like protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098942" }, "gene_names": [ { "name": "RERGL", "type": "recommended", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ] }, { "name": "RERGL", "type": "synonym", "evidence": [ { "id": "NP_001098942", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098942" } ] } ], "protein_names": [ { "name": "Ras-related and estrogen-regulated growth inhibitor-like protein", "type": "recommended", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66/entry#names_and_taxonomy" } ] }, { "name": "3.6.5.2", "type": "synonym", "evidence": [ { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66/entry#names_and_taxonomy" } ] }, { "name": "RERG/Ras-like protein", "type": "synonym", "evidence": [ { "id": "NP_001098942", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098942" }, { "id": "A6QP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QP66/entry#names_and_taxonomy" } ] }, { "name": "ras-related and estrogen-regulated growth inhibitor-like protein", "type": "synonym", "evidence": [ { "id": "NP_001098942", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098942" } ] } ], "function": [ { "annotation": "Binds GDP/GTP and may possess intrinsic GTPase activity.", "evidence": [ { "database": "UniProtKB", "id": "A6QP66", "url": "https://www.uniprot.org/uniprotkb/A6QP66#function" }, { "database": "UniProtKB", "id": "Q96A58", "url": "https://www.uniprot.org/uniprotkb/Q96A58#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QP66", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RERGL", "url": "https://www.uniprot.org/uniprotkb/A6QP66", "locus": { "chromosome": "5", "start_pos": 92008654, "end_pos": 91998258, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030493", "url": "https://www.ensembl.org/id/ENSBTAG00000030493" } ] } } ], "crossref": [ { "id": "A6QP66", "url": "https://alphafold.ebi.ac.uk/entry/A6QP66", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030493", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030493", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04146", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04146", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100125833", "url": "https://www.ncbi.nlm.nih.gov/gene/100125833", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051065", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051065", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100125833", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100125833", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LDYRCQF", "url": "https://omabrowser.org/oma/group/LDYRCQF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QP66", "url": "https://www.orthodb.org/?gene=A6QP66", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45704", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45704", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001098942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098942", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A6QP66", "url": "https://www.uniprot.org/uniprotkb/A6QP66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QP66-1", "url": "https://www.uniprot.org/uniprotkb/A6QP66-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNDVKLTVLGGEGTGKSALIVRFLTKRFIGEYASNFESIYNKHLCLEGKQLNLEIYDPCSQPQKAKFSLTSELHWADGFVIVYDISDRSSFAFAKALIYRIREPQTSHCKRPVESAVLLVGNKQDLCHVREVGWEEGHKLALDNRCQFCELSAAEQSLEVEMMFIRIIRDILTNFKLKEKRRYSGSKSMAKLINNVFGKRRKSV", "length": 204, "header": "sp|A6QP66-1|RERGL_BOVIN Isoform 1 of Ras-related and estrogen-regulated growth inhibitor-like protein OS=Bos taurus OX=9913 GN=RERGL PE=2 SV=1 CANONICAL=A6QP66-1" }, "isoforms": [ { "isoform_ac": "A6QP66-1", "url": "https://www.uniprot.org/uniprotkb/A6QP66/entry#A6QP66-1", "sequence": { "sequence": "MNDVKLTVLGGEGTGKSALIVRFLTKRFIGEYASNFESIYNKHLCLEGKQLNLEIYDPCSQPQKAKFSLTSELHWADGFVIVYDISDRSSFAFAKALIYRIREPQTSHCKRPVESAVLLVGNKQDLCHVREVGWEEGHKLALDNRCQFCELSAAEQSLEVEMMFIRIIRDILTNFKLKEKRRYSGSKSMAKLINNVFGKRRKSV", "length": 204, "header": "sp|A6QP66-1|RERGL_BOVIN Isoform 1 of Ras-related and estrogen-regulated growth inhibitor-like protein OS=Bos taurus OX=9913 GN=RERGL PE=2 SV=1 CANONICAL=A6QP66-1" }, "locus": { "chromosome": "5", "start_pos": 92008044, "end_pos": 91998298, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043032.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043032.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040628.3", "url": "https://www.ensembl.org/id/ENSBTAP00000040628.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:100125833", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100125833", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B7E8-1", "protein_name": "small monomeric GTPase", "gene_name": "RERGL", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNEVKLAVLGGEGTGKSALTVRFLTKRFIGEYASNFESIYNKYLCLEGKQLNLEIYDPCSQLQKAKFSLTSELHWADGFVIVYDISDRSSFAYAKALIYRIREPQNSHCKRAMESAVLLVGNKQDLCHVREVGWEEGQKLALDNRCQFCELSAAEQCLEVEMMFNRIIKAILTNFRLKEKRRPSGSKSMAKLINNVFGKRRKSV", "length": 204 }, "evidence": [ { "id": "A6QP66", "url": "https://omabrowser.org/oma/group/A6QP66/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2M2X0-1", "protein_name": "small monomeric GTPase", "gene_name": "Rergl", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSDVKLAVLGSKSTGKSALTVRFLTKRFIGEYASNFESIYNKQLCLEGKPLNLEIYDPCSQPQKAKCPLTSELHWADGFVIVYDISDRPSFAFAKALIYRIREPPTSHCKRMVEPAVVLVGNKQDLCHMREVGWDEGQKLAIDFRCQFCELSAAEQSLEVEVMFLRLIKDILMIFKHKEKRRPSGSKSMAKLINNVFGKRRKSV", "length": 204 }, "evidence": [ { "id": "A6QP66", "url": "https://omabrowser.org/oma/group/A6QP66/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZM99-1", "protein_name": "small monomeric GTPase", "gene_name": "Rergl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGDVKLAVLGGRGTGKSALTVRFLTKRFIGEYASNFESIYNKHLCLEGKPLNLEIYDPCSQSQKAKGSLTSDLHWADGFVIVYDISNRPSFAFAKALIYRIREPPMTHCKRVMEPAVVLVGNKQDLCHMREVGWDEGQKLATDYRCQFCELSAAEQSLEIEVMFLRLIKDILMIFKHKEKRRPSGSKSMAKLINNVFGKRRKSV", "length": 204 }, "evidence": [ { "id": "A6QP66", "url": "https://omabrowser.org/oma/group/A6QP66/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1BUS1-1", "protein_name": "small monomeric GTPase", "gene_name": "RERGL", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSEVKLAVLGGSGAGKSALAVRFLTRRFIGEYASNAECIYTKHFCLDGRQIHLEIYDPCSQQGKLSLTDELHWADGFIIVYDISDRASFAFAKALLYRIQESHIGACKKMVESSVFLVGNKQDLCHMREVGWDEGQKLAMDNKCQFCELSAAEHYQEVVAMFTKVLRSITSNLKAKEKRRPSGSKSMAKLINNVFGKRRKSV", "length": 202 }, "evidence": [ { "id": "A6QP66", "url": "https://omabrowser.org/oma/group/A6QP66/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A6QP66", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ], "pmid": "" }, { "name": "G protein activity", "id": "GO:0003925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003925", "evidence": [ { "database": "UniProtKB", "id": "A6QP66", "url": "https://www.uniprot.org/uniprotkb/A6QP66" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] } ] }, { "uniprot_ac": "A0AAA9S5W8", "gene_name": "RAB12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SVR8", "gene_name": "LOC789148", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "ec_number": "3.6.5.2", 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"http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47612", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47612:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47612:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193524", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QP92", "url": "https://www.uniprot.org/uniprotkb/A6QP92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QP92-1", "url": "https://www.uniprot.org/uniprotkb/A6QP92-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPQLLRDILCVIETFHKYAREDAATLTCTELKQLIQSEFEDIFQPCAIHAVERNLNLLNIDSNGAISFDEFVLAIFSFLNVCYLDTQSLLNSEPRQVSKPEGMPHDMGLQVTNETDQWTEGTSQTQDKVVLPSGTASSTHLSLEERAVEHNRVDPQGHTTAHKLPVETSEHSDSKNQHLKGDEQSQKVDQDVSATGDSRTQRETSKPMAGSEQISSHTKGEGQNKEILQKGDILARKQSGTETGGRFGEQEGSLGILHSPLEETTQRPGGSSEDQEVAGEKGVKGHPKSQEPSVQGKDEPSSEHVDLPKQAAARKPSQTQKSAAAKDESRTAETPEPPIQEKEYETRDLSVQGENRNVSETPMVRVERKGVRGPEVHQTVGQKQIEEKTQPPALEEPTEDKKYHELQESSKEKNAGEDSETHELNSEGGEQKDSESEGAISPGEEARHAEEGTAEALVNSKNAPEAEGTPGTRERIWELTTLENQSGEKNKMTTKIHDKLVKEDDGYQGEGSEPVATQNDERSPETPNSLTAEDGDSNSETSDLFVQGDSQSQTNPFRGSVQGSDSNNPETQKHLALSEEKRVQEAAVLAVRGEDEQVTEEHAQEHEGQGSATTGRGPAVEPRGHSDTQVFIVRDENTKSLEPGIPGAPNAGITKQLSVRQLPTKKDSRKELKDQSPSTKKEEDGALEAQEDLVKSLDENNAVSQKTCPATLEEETESPQQLAGEQSLSTKEHDPSVSESGLEERMQRDQELCLVERGAEHSSPLYEALQEKMLQQTNVTQGEHQNQAQTASVASPEIRRNQSSASLTNDSSDGLVFFIDRQALQKYIREFLPDEDPTGAQQISAPQALEDKQGRPQREELEPQKEASAPKQ", "length": 872, "header": "sp|A6QP92-1|TCHL1_BOVIN Isoform 1 of Trichohyalin-like protein 1 OS=Bos taurus OX=9913 GN=TCHHL1 PE=2 SV=2 CANONICAL=A6QP92-1" }, "isoforms": [ { "isoform_ac": "A6QP92-1", "url": "https://www.uniprot.org/uniprotkb/A6QP92/entry#A6QP92-1", "sequence": { "sequence": "MPQLLRDILCVIETFHKYAREDAATLTCTELKQLIQSEFEDIFQPCAIHAVERNLNLLNIDSNGAISFDEFVLAIFSFLNVCYLDTQSLLNSEPRQVSKPEGMPHDMGLQVTNETDQWTEGTSQTQDKVVLPSGTASSTHLSLEERAVEHNRVDPQGHTTAHKLPVETSEHSDSKNQHLKGDEQSQKVDQDVSATGDSRTQRETSKPMAGSEQISSHTKGEGQNKEILQKGDILARKQSGTETGGRFGEQEGSLGILHSPLEETTQRPGGSSEDQEVAGEKGVKGHPKSQEPSVQGKDEPSSEHVDLPKQAAARKPSQTQKSAAAKDESRTAETPEPPIQEKEYETRDLSVQGENRNVSETPMVRVERKGVRGPEVHQTVGQKQIEEKTQPPALEEPTEDKKYHELQESSKEKNAGEDSETHELNSEGGEQKDSESEGAISPGEEARHAEEGTAEALVNSKNAPEAEGTPGTRERIWELTTLENQSGEKNKMTTKIHDKLVKEDDGYQGEGSEPVATQNDERSPETPNSLTAEDGDSNSETSDLFVQGDSQSQTNPFRGSVQGSDSNNPETQKHLALSEEKRVQEAAVLAVRGEDEQVTEEHAQEHEGQGSATTGRGPAVEPRGHSDTQVFIVRDENTKSLEPGIPGAPNAGITKQLSVRQLPTKKDSRKELKDQSPSTKKEEDGALEAQEDLVKSLDENNAVSQKTCPATLEEETESPQQLAGEQSLSTKEHDPSVSESGLEERMQRDQELCLVERGAEHSSPLYEALQEKMLQQTNVTQGEHQNQAQTASVASPEIRRNQSSASLTNDSSDGLVFFIDRQALQKYIREFLPDEDPTGAQQISAPQALEDKQGRPQREELEPQKEASAPKQ", "length": 872, "header": "sp|A6QP92-1|TCHL1_BOVIN Isoform 1 of Trichohyalin-like protein 1 OS=Bos taurus OX=9913 GN=TCHHL1 PE=2 SV=2 CANONICAL=A6QP92-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 838, "start_aa": "Thr", "end_pos": 838, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr838", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:518825", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518825", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transition metal ion binding", "id": "GO:0046914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046914", "evidence": [ { "database": "UniProtKB", "id": "A6QP92", "url": "https://www.uniprot.org/uniprotkb/A6QP92" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 357, "end_pos": 359, "annotation": "n_glycosylation_sequon" }, { "start_pos": 484, "end_pos": 486, "annotation": "n_glycosylation_sequon" }, { "start_pos": 778, "end_pos": 780, "annotation": "n_glycosylation_sequon" }, { "start_pos": 801, "end_pos": 803, "annotation": "n_glycosylation_sequon" }, { "start_pos": 809, "end_pos": 811, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QP92-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 872, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QP92-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QP92" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 838 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 357, "end_pos": 359 }, { "start_pos": 484, "end_pos": 486 }, { "start_pos": 778, "end_pos": 780 }, { "start_pos": 801, "end_pos": 803 }, { "start_pos": 809, "end_pos": 811 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QPF4-1", "uniprot_ac": "A6QPF4", "uniprot_id": "M4A18_BOVIN", "mass": { "chemical_mass": 35566.0, "monoisotopic_mass": 35566.0 }, "refseq": { "ac": "NP_001095462", "name": "membrane-spanning 4-domains subfamily A member 18", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095462" }, "gene_names": [ { "name": "MS4A18", "type": "recommended", "evidence": [ { "id": "A6QPF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QPF4" } ] }, { "name": "MS4A18", "type": "synonym", "evidence": [ { "id": "NP_001095462", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095462" } ] } ], "protein_names": [ { "name": "Membrane-spanning 4-domains subfamily A member 18", "type": "recommended", "evidence": [ { "id": "A6QPF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QPF4/entry#names_and_taxonomy" } ] }, { "name": "membrane-spanning 4-domains subfamily A member 18", "type": "synonym", "evidence": [ { "id": "NP_001095462", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095462" } ] }, { "name": "membrane-spanning 4-domains, subfamily A, member 18", "type": "synonym", "evidence": [ { "id": "NP_001095462", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095462" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QPF4", "url": "https://www.uniprot.org/uniprotkb/A6QPF4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MS4A18", "url": "https://www.uniprot.org/uniprotkb/A6QPF4", "locus": { "chromosome": "29", "start_pos": 37103713, "end_pos": 37086016, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038312", "url": "https://www.ensembl.org/id/ENSBTAG00000038312" } ] } } ], "crossref": [ { "id": "A6QPF4", "url": "https://alphafold.ebi.ac.uk/entry/A6QPF4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038312", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038312", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514287", "url": "https://www.ncbi.nlm.nih.gov/gene/514287", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007237", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007237", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514287", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514287", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KVIQCDT", "url": "https://omabrowser.org/oma/group/KVIQCDT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QPF4", "url": "https://www.orthodb.org/?gene=A6QPF4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23320", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23320", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23320:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23320:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04103", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04103", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095462", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QPF4", "url": "https://www.uniprot.org/uniprotkb/A6QPF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QPF4-1", "url": "https://www.uniprot.org/uniprotkb/A6QPF4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMEQGVGANTVPGVTAPGNVYMIQARNPVAPGSKGQPVGMATYLTSRVTESDAGRANLQTPRVVIQNPAEVNATQGPPTALQHPTAVASLQTPPGEIQYSLGTTDLQTQPGGPQNPPTCAPGPMYTSNQFQWNMPFGSSFTFDPKKFIKDEVRTLGAIQILIGLTHIFTAINPSLYRQYSYSAISGYLVWGGIFFIISGSLSVEAEKDRSSCMVHGSVGMNVVSAIVSLAGVLLLLVDLIRNPVIDVKTVSGGLLPFVLLEFCLTCVVSHFGCQATCWNQFVNRTEVPTIVIANPANTPTGPFNATYSTTGHVNVITSSANPTSPTNAAAMVPPVPS", "length": 337, "header": "sp|A6QPF4-1|M4A18_BOVIN Isoform 1 of Membrane-spanning 4-domains subfamily A member 18 OS=Bos taurus OX=9913 GN=MS4A18 PE=2 SV=1 CANONICAL=A6QPF4-1" }, "isoforms": [ { "isoform_ac": "A6QPF4-1", "url": "https://www.uniprot.org/uniprotkb/A6QPF4/entry#A6QPF4-1", "sequence": { "sequence": "MMEQGVGANTVPGVTAPGNVYMIQARNPVAPGSKGQPVGMATYLTSRVTESDAGRANLQTPRVVIQNPAEVNATQGPPTALQHPTAVASLQTPPGEIQYSLGTTDLQTQPGGPQNPPTCAPGPMYTSNQFQWNMPFGSSFTFDPKKFIKDEVRTLGAIQILIGLTHIFTAINPSLYRQYSYSAISGYLVWGGIFFIISGSLSVEAEKDRSSCMVHGSVGMNVVSAIVSLAGVLLLLVDLIRNPVIDVKTVSGGLLPFVLLEFCLTCVVSHFGCQATCWNQFVNRTEVPTIVIANPANTPTGPFNATYSTTGHVNVITSSANPTSPTNAAAMVPPVPS", "length": 337, "header": "sp|A6QPF4-1|M4A18_BOVIN Isoform 1 of Membrane-spanning 4-domains subfamily A member 18 OS=Bos taurus OX=9913 GN=MS4A18 PE=2 SV=1 CANONICAL=A6QPF4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514287", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514287", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZUX6-1", "protein_name": "Membrane spanning 4-domains A18", "gene_name": "Ms4a18", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSNQENVSAVTVTVPGNVRAIQPTYAVVSGGQEQPLQKATMHPASATVLQCNPGSANFQNPHVVIQNPAGMTGLQARPTGLQYPAGMASVQTAPGVIQYSPEMTSVQILPGDPQNPLNTVPGPTQTSSHPQWNMSFMSFPEFNPKKFINEEVRTLGAIQILIGLFHVFSAFNPHIYWNFSVLGASGYLIWGGLSFIISGSLSVLAEKDTNSCVVNSSIGMNVISSIFSLTGILVIIIDLCFPTPGISFLMVTSGILLPFALLEFILTCVVSHFGCQAVCWPHFENMTVFPTMFGGNTVNTTTGPVSTTSPNSATNIPVQPTLPSDVPPEQLYHDVADHAQK", "length": 341 }, "evidence": [ { "id": "A6QPF4", "url": "https://omabrowser.org/oma/group/A6QPF4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "J3QN01-1", "protein_name": "Membrane-spanning 4-domains, subfamily A, member 18", "gene_name": "Ms4a18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSNQENVSAVTVPSNVQVMQPTYAVVSGSHEQPLGKTTTYPASATMLQYNPGSANFQNPQVMIQNPAGTTGLQAGPTGLQYSAGMAGVQAPPGVIQYSPEVTSVQIPPGDPQNPLNTVPGPTQTSSLPQWNMSFMTFPEFNPKKFINEEVRTLGAIQILIGLFHIFSAVNPQLYNTQFFVVPLLGVSGYLIWGGLSFIISGSLSVLAEKNSNSCVVNSSIGMNVVSSIFSLTGIIIIIVQLSIYPSEISPLMSSMKAAAGSILPFALLEFILTCIASHFGCQAVCCAHFQNMTMFPTIFGGNTVNTTTGPGNTTIPNSTTSIPVQTTLPSNVPLEQVYQDVAQK", "length": 344 }, "evidence": [ { "id": "A6QPF4", "url": "https://omabrowser.org/oma/group/A6QPF4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q3C1V0-1", "protein_name": "Membrane-spanning 4-domains subfamily A member 18", "gene_name": "MS4A18", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"NP_001094759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094759", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QPI4", "url": "https://www.uniprot.org/uniprotkb/A6QPI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QPI4-1", "url": "https://www.uniprot.org/uniprotkb/A6QPI4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLATVGSLLRLRLGRIPCCAPGAPPEVERRPVASLWPRGHPQYSCGGSPGSSEPPGSAEKVHRVPAEHKPSQFDKRILLWTGRFKAMEDIPPRIPPEMIDAARNKARVKACYIMIGLTIIACFAVIASAKRAAERHESLTSWNLAKKAKWREEAALAAQAKAK", "length": 163, "header": "sp|A6QPI4-1|F162B_BOVIN Isoform 1 of Protein FAM162B OS=Bos taurus OX=9913 GN=FAM162B PE=2 SV=1 CANONICAL=A6QPI4-1" }, "isoforms": [ { "isoform_ac": "A6QPI4-1", "url": "https://www.uniprot.org/uniprotkb/A6QPI4/entry#A6QPI4-1", "sequence": { "sequence": 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"annotation": "Serine protease inhibitor.", "evidence": [ { "database": "UniProtKB", "id": "A6QPQ2", "url": "https://www.uniprot.org/uniprotkb/A6QPQ2#function" }, { "database": "UniProtKB", "id": "Q9TTE1", "url": "https://www.uniprot.org/uniprotkb/Q9TTE1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QPQ2", "url": "https://www.uniprot.org/uniprotkb/A6QPQ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SERPINA3-8", "url": "https://www.uniprot.org/uniprotkb/A6QPQ2", "locus": {} } ], "crossref": [ { "id": "A6QPQ2", "url": "https://alphafold.ebi.ac.uk/entry/A6QPQ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd19551", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19551", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505820", "url": "https://www.ncbi.nlm.nih.gov/gene/505820", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000215", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000215", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023796", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023796", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505820", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505820", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A6QPQ2", "url": "https://www.orthodb.org/?gene=A6QPQ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11461:SF145", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11461:SF145", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00079", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00079", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001075181", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075181", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QPQ2", "url": "https://www.uniprot.org/uniprotkb/A6QPQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QPQ2-1", "url": "https://www.uniprot.org/uniprotkb/A6QPQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRAERMSPLLALGLLVSGLCSRVHCLPENVTPEERHKGTSVDGHSLASSNTDFAFSLYKQLALKNPNKNVIFSPLSISIALAFLSLGARGPTVTEILEGLKFNLTETLEREIHQGFQHLLQMLSRPSNELQLSVGNTMFVQEQLKLLDKFREDALALYTSEAFSTNFKDPETAKSLINDYVKNKTRGKIVDLFKDLDPLTKVILVNYIYFKAQWRTPFDPKQTYKSQFHVSKNKTVEVPMMSIGDLVTPYFRDEELDCTLVELTYTSNDSALFILPDEGKMQDLEAKLIPEMLTRWRESLYPRGIHELNLPRFSIATDYKLKDILSQLEIKKVFTQEADLSGITDDHELEVSQVVHKAVLDVGEEGTEGAAATGVKVGITSINNHIPLSFNRPFLIAIVLKDTQSIIFLGKVTNPSQA", "length": 418, "header": "sp|A6QPQ2-1|SPA38_BOVIN Isoform 1 of Serpin A3-8 OS=Bos taurus OX=9913 GN=SERPINA3-8 PE=2 SV=1 CANONICAL=A6QPQ2-1" }, "isoforms": [ { "isoform_ac": "A6QPQ2-1", "url": "https://www.uniprot.org/uniprotkb/A6QPQ2/entry#A6QPQ2-1", "sequence": { "sequence": "MRAERMSPLLALGLLVSGLCSRVHCLPENVTPEERHKGTSVDGHSLASSNTDFAFSLYKQLALKNPNKNVIFSPLSISIALAFLSLGARGPTVTEILEGLKFNLTETLEREIHQGFQHLLQMLSRPSNELQLSVGNTMFVQEQLKLLDKFREDALALYTSEAFSTNFKDPETAKSLINDYVKNKTRGKIVDLFKDLDPLTKVILVNYIYFKAQWRTPFDPKQTYKSQFHVSKNKTVEVPMMSIGDLVTPYFRDEELDCTLVELTYTSNDSALFILPDEGKMQDLEAKLIPEMLTRWRESLYPRGIHELNLPRFSIATDYKLKDILSQLEIKKVFTQEADLSGITDDHELEVSQVVHKAVLDVGEEGTEGAAATGVKVGITSINNHIPLSFNRPFLIAIVLKDTQSIIFLGKVTNPSQA", "length": 418, "header": "sp|A6QPQ2-1|SPA38_BOVIN Isoform 1 of Serpin A3-8 OS=Bos taurus OX=9913 GN=SERPINA3-8 PE=2 SV=1 CANONICAL=A6QPQ2-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 103, "start_aa": "Asn", "end_pos": 103, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn103", "evidence": [ { "id": 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"https://www.genome.jp/dbget-bin/www_bget?bta:781423", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RSCKTQP", "url": "https://omabrowser.org/oma/group/RSCKTQP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QQM4", "url": "https://www.orthodb.org/?gene=A6QQM4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13555", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13555", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13555:SF67", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13555:SF67", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13913", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13913", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A6QQM4", "url": "https://www.uniprot.org/uniprotkb/A6QQM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQM4-1", "url": "https://www.uniprot.org/uniprotkb/A6QQM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QQM4-2", "url": "https://www.uniprot.org/uniprotkb/A6QQM4-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEREEEKRVSTLQQSFHHSKEPTFLINQAVLFGESHSSFLPEIERDNRGEKIKTNPRKNRPGTVILSKQSSRRIMSGSQPRPPVIPSRRPGFRVCYICGREFGSQSLGIHEPQCLEKWRVENSKLPKHLRRPEPSKPPPFSGSGSYSLQAANEAAFQSSQAQLLPCETCGRTFLPDRLLVHQRSCKQKVEGPRAPSLDRSDDLAGLKKVSSGITTRPRTVICYICGREFGTLSLPIHEPKCLEKWKVENDRLPREFRQPLPQKPQPLLTGQPKHAGPRQGQLVSCPNCSQTFAPDRLPVHQRSCKAQPSGPKVQDLTLGSRGGLKESTNPKPQRNMAAPPVTDKPKMIRRPPTIVCYICGREYGTKSIAIHEPQCLKKWHNENNLLPKELRRPEPKKPEVRTITAKGFYDLDALNEAAWTSAQSQLVPCNICGRTFLPDRLIVHQRSCKPKVAK", "length": 454, "header": "sp|A6QQM4-1|ZN474_BOVIN Isoform 1 of Zinc finger protein 474 OS=Bos taurus OX=9913 GN=ZNF474 PE=2 SV=1 CANONICAL=A6QQM4-1" }, "isoforms": [ { "isoform_ac": "A6QQM4-1", "url": "https://www.uniprot.org/uniprotkb/A6QQM4/entry#A6QQM4-1", "sequence": { "sequence": "MEREEEKRVSTLQQSFHHSKEPTFLINQAVLFGESHSSFLPEIERDNRGEKIKTNPRKNRPGTVILSKQSSRRIMSGSQPRPPVIPSRRPGFRVCYICGREFGSQSLGIHEPQCLEKWRVENSKLPKHLRRPEPSKPPPFSGSGSYSLQAANEAAFQSSQAQLLPCETCGRTFLPDRLLVHQRSCKQKVEGPRAPSLDRSDDLAGLKKVSSGITTRPRTVICYICGREFGTLSLPIHEPKCLEKWKVENDRLPREFRQPLPQKPQPLLTGQPKHAGPRQGQLVSCPNCSQTFAPDRLPVHQRSCKAQPSGPKVQDLTLGSRGGLKESTNPKPQRNMAAPPVTDKPKMIRRPPTIVCYICGREYGTKSIAIHEPQCLKKWHNENNLLPKELRRPEPKKPEVRTITAKGFYDLDALNEAAWTSAQSQLVPCNICGRTFLPDRLIVHQRSCKPKVAK", "length": 454, "header": "sp|A6QQM4-1|ZN474_BOVIN Isoform 1 of Zinc finger protein 474 OS=Bos taurus OX=9913 GN=ZNF474 PE=2 SV=1 CANONICAL=A6QQM4-1" }, "locus": {} }, { "isoform_ac": "A6QQM4-2", "url": "https://www.uniprot.org/uniprotkb/A6QQM4/entry#A6QQM4-2", "sequence": { "sequence": "MIRRPPTIVCYICGREYGTKSIAIHEPQCLKKWHNENNLLPKELRRPEPKKPEVRTITAKGFYDLDALNEAAWTSAQSQLVPCNICGRTFLPDRLIVHQRSCKPKVAK", "length": 108, "header": "sp|A6QQM4-2|ZN474_BOVIN Isoform 2 of Zinc finger protein 474 OS=Bos taurus OX=9913 GN=ZNF474 PE=2 SV=1 CANONICAL=A6QQM4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:781423", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781423", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JYF2-1", "protein_name": "Zinc finger protein 474", "gene_name": "Zfp474", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MERGNERISSQPRGTIHHSKELTFFIQHAVPPSGSRSALAQKTQSGGLTKNPKVNIQKRRPGTAILSKHSSRIMSESQPRPPVIPSRRPGFRICYICGREFGSQSLAIHEPQCLEKWRIENSKLPKHLRRPEPSKPQPIGGSDSYNLQAAEEAFQSAQAQLLPCEYCGRTFLPDRLLVHQRSCKSKGENPRTANTNSPDVPTGLKKTSSGIPVRPRTLICYICGREFGTLSLPIHEPKCLEKWKIENDRLPRELRRSLPQKPQPLPTGQPSQKRASQAALVPCPNCGRTFAVHRLPVHQRSCRSQPNGLKLLNLNLERKGGPNGSINSKHQRKMKAPNGDKVTGVI", "length": 346 }, "evidence": [ { "id": "A6QQM4", "url": "https://omabrowser.org/oma/group/A6QQM4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RLC3-1", "protein_name": "C2HC/C3H-type domain-containing protein", "gene_name": "LOC100525452", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MERGKEKRVSNKLQQCFHHSKEPTFLINQAVLSSDSHSSLLPETEHANPGEKIKTNHQKNRPGTVILSKRSIRRIMSESQPSPPVIPSRRPGFRVCYICGREFGSQSLGIHEPQCLEKWRIENSKLPKHLRRPEPSKPPPLRGSGSYNLQAANEAAFQSSQAQLLPCEYCGRTFLPDRLLVHQRSCKPKGEGPGVTNPSSSDDLAGLKKASGGIPSRPRTFICYICGREFGTLSLPIHEPKCLEKWKIENNRLPRELRRPLPQKPQPPPAGQSNQEGPSQAQLVSCPNCSRTFAPDRLLVHQRSCRAQPSGPKVQDLTSESKGGLKGSPKSKQQRNMAAPSVIDKPTMIRRPPTVVCYICGREYGTKSIAIHEPQCLKKWHNENNLLPKELRRPEPKKPEVRTITAKGFYDLDALNEAAWTSAQSQLVPCYICGRTFLPDRLIVHQRSCKPKVAK", "length": 455 }, "evidence": [ { "id": "A6QQM4", "url": "https://omabrowser.org/oma/group/A6QQM4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6S9Z5-1", "protein_name": "Zinc finger protein 474", "gene_name": "ZNF474", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MERGKKKRISNKLQQTFHHSKEPTFLINQAGLLSSDSYSSLSPETESVNPGENIKTDTQKKRPGTVILSKLSSRRIISESQLSPPVIPARRPGFRVCYICGREFGSQSIAIHEPQCLQKWHIENSKLPKHLRRPEPSKPQSLSSSGSYSLQATNEAAFQSAQAQLLPCESCGRTFLPDHLLVHHRSCKPKGEGPRAPHSNSSDHLTGLKKACSGTPARPRTVICYICGKEFGTLSLPIHEPKCLEKWKMENDRLPVELHQPLPQKPQPLPNAQSSQAGPNQAQLVFCPHCSRIFTSDRLLVHQRSCKTHPYGPKYQNLNLGSKGGLKEYTNSKQQRNRAAPSVTDKVIHATQDALGEPGGALCL", "length": 364 }, "evidence": [ { "id": "A6QQM4", "url": "https://omabrowser.org/oma/group/A6QQM4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6V5K9-1", "protein_name": "Zinc finger protein 474", "gene_name": "Znf474", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESGNERISSQSQGTIHLSKEPTFLIQQATLPSDLHSTLLQETQCGGLTKNIKANTQKRRPGTVILSKRSSRIMSETQPRPPVIPSRRPGFRICYICGREFGSQSLAIHEPQCLEKWRTENSKLPKHLRRPEPSKPQPIGGTDSHSLQAANEEAFQSAQAQLLPCENCGRTFLPDRLLVHQRSCKPKGENPGPPSMGSSNVPTGLKKASSGIPARPRTLICYICGREFGTLSLPIHEPKCLEKWKIENDQLPRELRRPQPQKPQPLPAGQSSQEGASQAALVPCPNCGRTFAVDRLPVHQRSCKSQPSGPKTSNSNIERKGGPNPPTNSKQQRNMEAPNGDKVTGVI", "length": 347 }, "evidence": [ { "id": "A6QQM4", "url": "https://omabrowser.org/oma/group/A6QQM4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A6QQM4", "url": "https://www.uniprot.org/uniprotkb/A6QQM4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QQM4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 454, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QQM4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QQM4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "A6QQM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQM4#function" }, { "id": "A6QQM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQM4" }, { "id": "PRU01371", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01371" } ], "binding_site_uniprot": 110, "amino_acid": "His", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 110, "end_pos": 110, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "A6QQM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQM4#function" }, { "id": "A6QQM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQM4" }, { "id": "PRU01371", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01371" } ], "binding_site_uniprot": 114, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "1", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 114, "end_pos": 114, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A6QQM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQM4#function" }, { "id": "A6QQM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQM4" }, { "id": "PRU01371", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01371" } ], "binding_site_uniprot": 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"glycosite_overlap": "" }, { "evidence": [ { "id": "A6QQM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQM4#function" }, { "id": "A6QQM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQM4" }, { "id": "PRU01371", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01371" } ], "binding_site_uniprot": 222, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "3", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000255", "start_pos": 222, "end_pos": 222, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A6QQM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQM4#function" }, { "id": "A6QQM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQM4" }, { "id": "PRU01371", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01371" } ], "binding_site_uniprot": 225, "amino_acid": "Cys", "chebi_lig_id": 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}, { "id": "DGPFQCG", "url": "https://omabrowser.org/oma/group/DGPFQCG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QR00", "url": "https://www.orthodb.org/?gene=A6QR00", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24376", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24376", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24376:SF243", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24376:SF243", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13894", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13894", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095467", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QR00", "url": "https://www.uniprot.org/uniprotkb/A6QR00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QR00-1", "url": "https://www.uniprot.org/uniprotkb/A6QR00-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEVVAEVAEVAEMPTQMSPRVMEMSAPILGEKMELSTELTEMTPGEAVASSLFFQFMCSECGNLYNTLEEVLSHQEQHVPTVTEEEALTTQDTGLEPELVPGTEEGPFQCGECSQLILSPRELLAHQDAHLRESASQIQYQCGDCQELFPSPELWVAHRKAQHLSTAAAKPPVPPPLPPVTPPPPPPAPLEVKMEPYECPECSTLCTTPEEFLEHQGTHFDSLEKEEHNGLEEEEEDDEDDNEETEEEEEAAAEVGDDAKGGDKSAAGQAQGSGDGPPHCTSAGTRRRHRRASHGPASAAHPFYCSQCQRSFSSANRLLAHGRAHVGGTHECTTCSKVFKKAASLEQHLRLHRGEARYLCVDCGRGFGTELTLVAHRRAHTANPLHRCRCGKTFSNMTKFLYHRRTHAGKSGAPPSAAPPTVASAVASLAPAEPTPPPPAPPTPPAQLPCPQCPKSFASASRLSRHRRAVHGPPERRHRCGVCGKGFKKLVHVRNHLRTHTGERPFQCHACGKTFASLANLSRHQLTHTGVRPYQCLDCGKRFTQSSNLQQHRRLHLRPVAFARAPRLPITGLYNKSPYYCGTCGRWFRAMAGLRLHQRVHAQARTLTLQPPRSPPPAPPPPPEPQQTIMCTELGETIAIIETSQPLALADTLQLCQAALGASEASGLLQLDTAFM", "length": 677, "header": "sp|A6QR00-1|ZN526_BOVIN Isoform 1 of Zinc finger protein 526 OS=Bos taurus OX=9913 GN=ZNF526 PE=2 SV=1 CANONICAL=A6QR00-1" }, "isoforms": [ { "isoform_ac": "A6QR00-1", "url": "https://www.uniprot.org/uniprotkb/A6QR00/entry#A6QR00-1", "sequence": { "sequence": "MAEVVAEVAEVAEMPTQMSPRVMEMSAPILGEKMELSTELTEMTPGEAVASSLFFQFMCSECGNLYNTLEEVLSHQEQHVPTVTEEEALTTQDTGLEPELVPGTEEGPFQCGECSQLILSPRELLAHQDAHLRESASQIQYQCGDCQELFPSPELWVAHRKAQHLSTAAAKPPVPPPLPPVTPPPPPPAPLEVKMEPYECPECSTLCTTPEEFLEHQGTHFDSLEKEEHNGLEEEEEDDEDDNEETEEEEEAAAEVGDDAKGGDKSAAGQAQGSGDGPPHCTSAGTRRRHRRASHGPASAAHPFYCSQCQRSFSSANRLLAHGRAHVGGTHECTTCSKVFKKAASLEQHLRLHRGEARYLCVDCGRGFGTELTLVAHRRAHTANPLHRCRCGKTFSNMTKFLYHRRTHAGKSGAPPSAAPPTVASAVASLAPAEPTPPPPAPPTPPAQLPCPQCPKSFASASRLSRHRRAVHGPPERRHRCGVCGKGFKKLVHVRNHLRTHTGERPFQCHACGKTFASLANLSRHQLTHTGVRPYQCLDCGKRFTQSSNLQQHRRLHLRPVAFARAPRLPITGLYNKSPYYCGTCGRWFRAMAGLRLHQRVHAQARTLTLQPPRSPPPAPPPPPEPQQTIMCTELGETIAIIETSQPLALADTLQLCQAALGASEASGLLQLDTAFM", "length": 677, "header": "sp|A6QR00-1|ZN526_BOVIN Isoform 1 of Zinc finger protein 526 OS=Bos taurus OX=9913 GN=ZNF526 PE=2 SV=1 CANONICAL=A6QR00-1" }, "locus": { "chromosome": "18", "start_pos": 51033555, "end_pos": 51032532, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092988.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092988.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094970.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094970.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 182, "start_aa": "Thr", "end_pos": 182, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr182", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 436, "start_aa": "Thr", "end_pos": 436, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr436", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 444, "start_aa": "Thr", "end_pos": 444, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr444", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:514418", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514418", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6ACH9-1", "protein_name": "Zinc finger protein 526", "gene_name": "Zfp526", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGEGAAGWAGKTALGIAREWRKREGHAKGRRALGPALGAGAERDDRQLLPVCPRGVGGAPAVCWTQLELSCTPHPCRGLSRCGAEESGTACPTMAEMVAEAEMPTQSPGAVEISTAVSGELAEMTTAVTEMTSGEALASSLFFQHHQFMCSECGSLYNTLEEVLSHQEQHLLTMSEEETLTTQDTGLESELVPSTGEGPFQCGECSQLILSPSELLAHQDAHLQESASQIQYQCGDCQELFPSPELWVAHRKTQHLSSAADEPPPPLPPPNPPPPPPEVKMEPYECPECSTLCATPEEFLEHQGTHFDSLEKEERNGLEEEGEDEEEEGEEEEDDDEETDEEETSTELTADDTEGDRSTADPARSCGDCPQHCTSSGARRKHRRASHGPASATHPFHCSQCQRSFSSANRLVAHGRAHVGGTYECTTCSKVFKKAASLEQHQRLHRGEARYLCVDCGRGFGTELTLVAHRRAHTANPLHRCRCGKTFSNMTKFLYHRRTHTGKSGTPTKVATVSPAPAEPTPMPPPPPAQLPCPQCPKSFASASRLSRHRRAVHGPPERRHRCGVCGKGFKKLVHVRNHLRTHTGERPFQCHSCGKTFASLANLSRHQLTHTGVRPYQCLDCGKRFTQSSNLQQHRRLHLRPVAFARAPRLPITGLYNKSPYYCGTCGRWFRAMAGLRLHQRVHARARSLTLQPPRSPSPVPPPAPEPQQTIMCTELGETIAIIETSQPLALEDTLQLCQAALGASEASGLLQLDTAFV", "length": 759 }, "evidence": [ { "id": "A6QR00", "url": "https://omabrowser.org/oma/group/A6QR00/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LFV3-1", "protein_name": "Zinc finger protein 526", "gene_name": "ZNF526", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAEVAEVAEMPTQMSPGAMEMSTPMLGEKTERSAEVTEIAPGEALASSLFFQFMCSECGSLYNTLEEVLSHQEQHVPTVMEEEALTSQDTCLEPELVPGPEDGPFQCAECSQLILSPSELLAHQDAHLRESASQIQYQCGDCQELFPSPELWVAHRKAQHLSAAAVKPPVPPPLPPLTPPPPSPAPPEVKMEPYECPECSTLCTSPEEFLEHQGTHFDSLEKEERNGLEEEEEEEEDDDEETEDEEEAAAEVGDNAMEGDKSVASQAQGCGDCPQHWTSAGARRRHRRTSRGPASAAHPFHCSQCQRSFSSANRLLAHGRAHVGGTHECTTCSKVFKKAASLEQHLRLHRGEARYLCVDCGRGFGTELTLVAHRRAHTANPLHRCRCGKTFSNMTKFLYHRRTHAGKSGAPPGAAAAAVTSPAPAEPSPLPPPPAPPAQLPCPQCSKSFATASRLSRHRRAVHGPPERRHRCGVCGKGFKKLVHVRNHLRTHTGERPFQCHSCGKTFASLANLSRHQLTHTGVRPYQCLDCGKRFTQSSNLQQHRRLHLRPVAFARAPRLPITGLYNKSPYYCGTCGRWFRAMAGLRLHQRVHAQARTVTLQPPRSPPPAPPPPPEPQQTIMCTELGETIAIIETSQPLALVDTLQLCQAALGATEASGLLQLDTAFV", "length": 668 }, "evidence": [ { "id": "A6QR00", "url": "https://omabrowser.org/oma/group/A6QR00/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8BI66-1", "protein_name": "Zinc finger protein 526", "gene_name": "Znf526", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEMVAEAAEIPTQSSGAVEISTAVSGELAEMATAVTEMTSGEALASSLFFQHHQFMCSECGSLYNTLEEVLSHQEQHLLTMSEEETLTTQDAGLEPELVPSTGEGPFQCGECSQLILSPSELLAHQDAHLQESASQIQYQCGDCQELFPSPELWVAHRKTQHLSSAADEPPSPLPPPTPPPPPPPPPPPPPPEVKMEPYECPECSTLCATPEEFLEHQGTHFDSLEKEEHNGLEEEEEDEEEGEEEEDDDDEETDEEEASSELTADDTGSNKSTADSAQSCGDCPQHCTSSGARHKHRRASHGPASATHAFHCSQCQRSFSSANRLVAHGRAHVGGTHECTTCSKVFKKAASLEQHQRLHRGEARYLCVDCGRGFGTELTLVAHRRAHTANPLHRCRCGKTFSNMTKFLYHRRTHTGKSGTPTRVATVSPAPAEPTPPPLPPPAQLPCPQCPKSFASASRLSRHRRAVHGPPERRHRCGVCGKGFKKLVHVRNHLRTHTGERPFQCHSCGKTFASLANLSRHQLTHTGVRPYQCLDCGKRFTQSSNLQQHRRLHLRPVAFARAPRLPITGLYNKSPYYCGTCGRWFRAMAGLRLHQRVHARARSLTLQPPRSPSPVPPPPPEPQQTIMCTELGETIAIIETSQPLALEDTLQLCQAALGASEASGLLQLDTAFV", "length": 675 }, "evidence": [ { "id": "A6QR00", "url": "https://omabrowser.org/oma/group/A6QR00/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TF50-1", "protein_name": "Zinc finger protein 526", "gene_name": "ZNF526", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEVVAEVAEMPTQMSPGAVEMSTPMSAEMMEMSTEVTEMTPGEALASSLFFQHHQFMCSECGSLYNTLEEVLSHQEQHMLAVSEEEALTTQNVGLEPELVPGAEGPFQCGECSQLILSPGELLAHQDAHLRESANQIQYQCWDCQELFPSPELWVAHRKAQHLSATVAEPPVPPPLPPPTPLPPPSPPSEVKMEPYECPECSTLCATPEEFLEHQGTHFDSLEKEERNGLEEEEEDDEEDEEDDEEMEDEEAMAEVGDDAVGGDESTAGWAQGCGDCPQHQPSAGARRQHRRTAHSPASATHPFHCSQCQRSFSSANRLQAHGRAHVGGTHECTTCSKVFKKAASLEQHLRLHRGEARYLCVDCGRGFGTELTLVAHRRAHTANPLHRCRCGKTFSNMTKFLYHRRTHAGKSGAPPTGATAPPAPAEPTPPPPPPAPPAQLPCPQCSKSFASASRLSRHRRAVHGPPERRHRCGVCGKGFKKLIHVRNHLRTHTGERPFQCHSCGKTFASLANLSRHQLTHTGARPYQCLDCGKRFTQSSNLQQHRRLHLRPVAFARAPRLPITGLYNKSPYYCGTCGRWFRAMAGLRLHQRVHARARTLTLQPPRSPSPAPPPPPEPQQTIMCTELGETIAIIETSQPLALEDTLQLCQAALGASEAGGLLQLDTAFV", "length": 670 }, "evidence": [ { "id": "A6QR00", "url": "https://omabrowser.org/oma/group/A6QR00/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A6QR00", "url": "https://www.uniprot.org/uniprotkb/A6QR00" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A6QR00", "url": "https://www.uniprot.org/uniprotkb/A6QR00" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A6QR00", "url": "https://www.uniprot.org/uniprotkb/A6QR00" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A6QR00", "url": "https://www.uniprot.org/uniprotkb/A6QR00" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 397, "end_pos": 399, "annotation": "n_glycosylation_sequon" }, { "start_pos": 521, "end_pos": 523, "annotation": "n_glycosylation_sequon" }, { "start_pos": 576, "end_pos": 578, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QR00-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 677, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QR00-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QR00" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 182, 436, 444 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 397, "end_pos": 399 }, { "start_pos": 521, "end_pos": 523 }, { "start_pos": 576, "end_pos": 578 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QR06-1", "uniprot_ac": "A6QR06", "uniprot_id": "TADA1_BOVIN", "mass": { "chemical_mass": 37419.0, "monoisotopic_mass": 37419.0 }, "refseq": { "ac": "NP_001094576", "name": "transcriptional adapter 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094576" }, "gene_names": [ { "name": "TADA1", "type": "recommended", "evidence": [ { "id": "A6QR06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR06" } ] }, { "name": "TADA1L", "type": "synonym", "evidence": [ { "id": "NP_001094576", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094576" }, { "id": "A6QR06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR06" } ] }, { "name": "TADA1", "type": "synonym", "evidence": [ { "id": "NP_001094576", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094576" } ] } ], "protein_names": [ { "name": "Transcriptional adapter 1", "type": "recommended", "evidence": [ { "id": "A6QR06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR06/entry#names_and_taxonomy" } ] }, { "name": "Transcriptional adapter 1-like protein", "type": "synonym", "evidence": [ { "id": "A6QR06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR06/entry#names_and_taxonomy" } ] }, { "name": "transcriptional adapter 1-like protein", "type": "synonym", "evidence": [ { "id": "NP_001094576", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094576" } ] }, { "name": "transcriptional adapter 1", "type": "synonym", "evidence": [ { "id": "NP_001094576", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094576" } ] } ], "function": [ { "annotation": "Probably involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A6QR06", "url": "https://www.uniprot.org/uniprotkb/A6QR06#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QR06", "url": "https://www.uniprot.org/uniprotkb/A6QR06" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TADA1", "url": "https://www.uniprot.org/uniprotkb/A6QR06", "locus": { "chromosome": "3", "start_pos": 2050061, "end_pos": 2034298, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010456", "url": "https://www.ensembl.org/id/ENSBTAG00000010456" } ] } } ], "crossref": [ { "id": "A6QR06", "url": "https://alphafold.ebi.ac.uk/entry/A6QR06", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010456", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010456", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22934", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22934", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "521918", "url": "https://www.ncbi.nlm.nih.gov/gene/521918", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR024738", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024738", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521918", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521918", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NIMTEDQ", "url": "https://omabrowser.org/oma/group/NIMTEDQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QR06", "url": "https://www.orthodb.org/?gene=A6QR06", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21277", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21277", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21277:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21277:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12767", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12767", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001094576", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094576", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QR06", "url": "https://www.uniprot.org/uniprotkb/A6QR06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QR06-1", "url": "https://www.uniprot.org/uniprotkb/A6QR06-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATFVSELEAAKKNLSEALGDNVKQYWANLKLWFKQKISKEEFDLEAHRLLTQDNVHSHNDFLLAILTRCQILVSTPEGAGSLPWTGGSAAKPGKPKGKKKLSSVRQKFDHRFQPQNPLSGAQQFVAKDPQDDDDLKLCSHTMMLPTRGQLEGRMIVTAYEHGLDNVTEEAVSAVVYAVENHLKDILSSVVSRRKAYRLRDGHFKYAFGSNVTPQPYLKNSVVAYNSLIESPPALSAPFAGQNPASHPPPDDAEQQAALLLACSGDTLPASLPPVNMYDLFEALQVHREVIPTHTVYALNIERIIMKLWHPNHEELQQDKVHRQRLAAKEGLLFC", "length": 335, "header": "sp|A6QR06-1|TADA1_BOVIN Isoform 1 of Transcriptional adapter 1 OS=Bos taurus OX=9913 GN=TADA1 PE=2 SV=1 CANONICAL=A6QR06-1" }, "isoforms": [ { "isoform_ac": "A6QR06-1", "url": "https://www.uniprot.org/uniprotkb/A6QR06/entry#A6QR06-1", "sequence": { "sequence": "MATFVSELEAAKKNLSEALGDNVKQYWANLKLWFKQKISKEEFDLEAHRLLTQDNVHSHNDFLLAILTRCQILVSTPEGAGSLPWTGGSAAKPGKPKGKKKLSSVRQKFDHRFQPQNPLSGAQQFVAKDPQDDDDLKLCSHTMMLPTRGQLEGRMIVTAYEHGLDNVTEEAVSAVVYAVENHLKDILSSVVSRRKAYRLRDGHFKYAFGSNVTPQPYLKNSVVAYNSLIESPPALSAPFAGQNPASHPPPDDAEQQAALLLACSGDTLPASLPPVNMYDLFEALQVHREVIPTHTVYALNIERIIMKLWHPNHEELQQDKVHRQRLAAKEGLLFC", "length": 335, "header": "sp|A6QR06-1|TADA1_BOVIN Isoform 1 of Transcriptional adapter 1 OS=Bos taurus OX=9913 GN=TADA1 PE=2 SV=1 CANONICAL=A6QR06-1" }, "locus": { "chromosome": "3", "start_pos": 2048894, "end_pos": 2034404, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013804.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013804.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013804.4", "url": "https://www.ensembl.org/id/ENSBTAP00000013804.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:521918", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521918", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YER6-1", "protein_name": "Transcriptional adapter 1", "gene_name": "TADA1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MATYVSELEAAKKSLSEALGENVKQYWANLKLWFKQKISKEEFDLEARRLLTQDNVHSHNDFLLAILTRCQILVSAPEGAGSLPWPGGSATKPGKPKGKKKISSVRQKFDHRFQPQNPLSGAQQFVAKDPQEEDDLKLCSHTMMLPTRGQLEGRMIVTAYEHGLDNVTEDAVTAVVYAVENHLKDILTSVISRRKAYRLRDGHFKYAFGSNVNPQPYLKNSVVAYNNLIECPPTCVTPSAGQTVAPQPPPDDAEQQAALLLACSGDTLPASLPPVNMYDLFEALQVHKEVIPAHTVYALNIERIVMKLWHPNHEELQQDKIHRQHLAAKEGLLLC", "length": 335 }, "evidence": [ { "id": "A6QR06", "url": "https://omabrowser.org/oma/group/A6QR06/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S248-1", "protein_name": "Transcriptional adapter 1", "gene_name": "TADA1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATFVSELEAAKKNLSEALGDNVKQYWANLKLWFKQKISKEEFDLEAHRLLTQDNVHSHNDFLLAILTRCQILVSTPEGAGSLPWTGGSAAKPGKPKGKKKLSSVRQKFDHRFQPQNPLSGAQQFVAKDPQDDDDLKLCSHTMMLPTRGQLEGRMIVTAYEHGLDNVTEEAVSAVVYAVENHLKDILTSVVSRRKAYRLRDGHFKYAFGSNVTPQPYLKNSVVAYNNLIESPPAFSAPCAGQNPASHPPPDDAEQQAALLLACSGDTLPASLPPVNMYDLFEALQVHREVIPTHTVYALNIERIIMKLWHPNHEELQQDKVHRQRLAAKEGLLLC", "length": 335 }, "evidence": [ { "id": "A6QR06", "url": "https://omabrowser.org/oma/group/A6QR06/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HE77-1", "protein_name": "Transcriptional adapter 1", "gene_name": "Tada1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MATFVSELEAAKKNLSEALGDNVKQYWANLKLWFKQKISKEEFDLEAHRLLTQDNVHSHNDFLLAILTRCQILVSTPEGAGSLPWTGGSAAKPGKPKGKKKLSSVRQKFDHRFQPQNPLSGAQQFVAKDPQDDDDLKLCSHTMMLPTRGQLEGRMIVTAYEHGLDNVTEEAVSAVVYAVENHLKDILTSVVSRRKAYRVRDGHFKYAFGSNVTPQPYLKNSVVAYNNLVEGPPAFSAPCASQNSASQPHPDDAEQQAAFLLACSGDTLPASLPPVNMYDLFEALQVHREVIPTHTVYALNIERIIMKLWHPNHEELQQDKVHRQRLAAKEGLLLC", "length": 335 }, "evidence": [ { "id": "A6QR06", "url": "https://omabrowser.org/oma/group/A6QR06/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5BJQ7-1", "protein_name": "Transcriptional adapter 1", "gene_name": "Tada1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATFVSELEAAKKNLSEALGDNVKQYWANLKLWFKQKISKEEFDLEAHRLLTQDNVHSHNDFLLAILTRCQILVSTPEGAGSLPWTGGSAAKPGKPKGKKKLSSVRQKFDHRFQPQNPLSGAQQFVAKDPQDDDDLKLCSHTMMLPTRGQLEGRMIVTAYEHGLDNVTEEAVSAVVYAVENHLKDILTSVVSRRKAYRVRDGHFKYAFGSNVTPQPYLKNSVVAYNNLVEGPPAFPAPCASQNPASHPHTDDAEQQAAFLLACSGDTLPASLPPVNMYDLFEALQVHREVIPTHTVYALNIERIIMKLWHPNHEELQQDKVHRQRLAAKEGLLLC", "length": 335 }, "evidence": [ { "id": "A6QR06", "url": "https://omabrowser.org/oma/group/A6QR06/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8IPA1-1", "protein_name": "Transcriptional adapter 1-2", "gene_name": "Ada1-2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLTDRVLATKEALVVALGDNWERYRANMKNWFRSRWTKEEFDAESRKILTPDKLHLHNQFLLALLNKIDAFAPLENPPAVQTSSSSGNRSKRRKRSSRTFAERLNFELSDVLDFVAEDNMQIIRPPTTIGIPSDQQQQQLQSQRYCAQELFLPDAGFIMGRFLIGAWEIGLVSVDDNVAEYVAMAVQVLLKDLLSAIIKKRKHYKTSGEGNFYYDVGAPLRDPSLRNTVTRQKVDDTPLELDKELNTANFMRRQNDDVTFLSACEEVQPTERTVITLKDCQLALRDRNLIGSHAVYSINMERLNMMMH", "length": 308 }, "evidence": [ { "id": "A6QR06", "url": "https://omabrowser.org/oma/group/A6QR06/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q96BN2-1", "protein_name": "Transcriptional adapter 1", "gene_name": "TADA1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATFVSELEAAKKNLSEALGDNVKQYWANLKLWFKQKISKEEFDLEAHRLLTQDNVHSHNDFLLAILTRCQILVSTPDGAGSLPWPGGSAAKPGKPKGKKKLSSVRQKFDHRFQPQNPLSGAQQFVAKDPQDDDDLKLCSHTMMLPTRGQLEGRMIVTAYEHGLDNVTEEAVSAVVYAVENHLKDILTSVVSRRKAYRLRDGHFKYAFGSNVTPQPYLKNSVVAYNNLIESPPAFTAPCAGQNPASHPPPDDAEQQAALLLACSGDTLPASLPPVNMYDLFEALQVHREVIPTHTVYALNIERIITKLWHPNHEELQQDKVHRQRLAAKEGLLLC", "length": 335 }, "evidence": [ { "id": "A6QR06", "url": "https://omabrowser.org/oma/group/A6QR06/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99LM9-1", "protein_name": "Transcriptional adapter 1", "gene_name": "Tada1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATFVSELEAAKKNLSEALGDNVKQYWANLKLWFKQKISKEEFDLEAHRLLTQDNVHSHNDFLLAILTRCQILVSTPEGAGSLPWTGGSAAKPGKPKGKKKLSSVRQKFDHRFQPQNPLSGAQQFVAKEPQGDDDLKLCSHTMMLPTRGQLEGRMIVTAYEHGLDNVTEEAVSAVVYAVENHLKDILTSVVSRRKAYRVRDGHFKYAFGSNVTPQPYLKNSVVAYNNLVEGPPAFSAPCANQSPASQPHPDDAEQQAAFLLACSGDTLPASLPPVNMYDLFEALQVHREVIPTHTVYALNIERIIMKLWHPNHEELQQDKVHRQRLAAKEGLLLC", "length": 335 }, "evidence": [ { "id": "A6QR06", "url": "https://omabrowser.org/oma/group/A6QR06/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "A6QR06", "url": "https://www.uniprot.org/uniprotkb/A6QR06" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A6QR06", "url": "https://www.uniprot.org/uniprotkb/A6QR06" } ], "pmid": "" }, { "name": "SAGA complex", "id": "GO:0000124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000124", "evidence": [ { "database": "UniProtKB", "id": "A6QR06", "url": "https://www.uniprot.org/uniprotkb/A6QR06" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A6QR06", "url": "https://www.uniprot.org/uniprotkb/A6QR06" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A6QR06", "url": "https://www.uniprot.org/uniprotkb/A6QR06" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 14, "end_pos": 16, "annotation": "n_glycosylation_sequon" }, { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QR06-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 335, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QR06-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QR06" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 14, "end_pos": 16 }, { "start_pos": 166, "end_pos": 168 }, { "start_pos": 211, "end_pos": 213 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A6QR22-1", "uniprot_ac": "A6QR22", "uniprot_id": "TM40L_BOVIN", "mass": { "chemical_mass": 33811.0, "monoisotopic_mass": 33811.0 }, "refseq": { "ac": "NP_001014853", "name": "mitochondrial import receptor subunit TOM40B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014853" }, "gene_names": [ { "name": "TOMM40L", "type": "recommended", "evidence": [ { "id": "A6QR22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR22" } ] }, { "name": "TOMM40L", "type": "synonym", "evidence": [ { "id": "NP_001014853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014853" } ] }, { "name": "Tom40B", "type": "synonym", "evidence": [ { "id": "NP_001014853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014853" } ] } ], "protein_names": [ { "name": "Mitochondrial import receptor subunit TOM40B", "type": "recommended", "evidence": [ { "id": "A6QR22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR22/entry#names_and_taxonomy" } ] }, { "name": "Protein TOMM40-like", "type": "synonym", "evidence": [ { "id": "A6QR22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR22/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial import receptor subunit TOM40B", "type": "synonym", "evidence": [ { "id": "NP_001014853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014853" } ] }, { "name": "protein TOMM40-like", "type": "synonym", "evidence": [ { "id": "NP_001014853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014853" } ] }, { "name": "translocase of outer mitochondrial membrane 40 homolog-like", "type": "synonym", "evidence": [ { "id": "NP_001014853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014853" } ] }, { "name": "translocase of outer mitochondrial membrane 40B", "type": "synonym", "evidence": [ { "id": "NP_001014853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014853" } ] } ], "function": [ { "annotation": "Potential channel-forming protein implicated in import of protein precursors into mitochondria.", "evidence": [ { "database": "UniProtKB", "id": "A6QR22", "url": "https://www.uniprot.org/uniprotkb/A6QR22#function" }, { "database": "UniProtKB", "id": "A4F267", "url": "https://www.uniprot.org/uniprotkb/A4F267#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QR22", "url": "https://www.uniprot.org/uniprotkb/A6QR22" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TOMM40L", "url": "https://www.uniprot.org/uniprotkb/A6QR22", "locus": { "chromosome": "3", "start_pos": 8275799, "end_pos": 8280293, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009213", "url": "https://www.ensembl.org/id/ENSBTAG00000009213" } ] } } ], "crossref": [ { "id": "A6QR22", "url": "https://alphafold.ebi.ac.uk/entry/A6QR22", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009213", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009213", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07305", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07305", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505393", "url": "https://www.ncbi.nlm.nih.gov/gene/505393", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR023614", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023614", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027246", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027246", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505393", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505393", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WTEMGNT", "url": "https://omabrowser.org/oma/group/WTEMGNT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A6QR22", "url": "https://www.orthodb.org/?gene=A6QR22", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10802", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10802", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01459", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01459", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001014853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014853", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6QR22", "url": "https://www.uniprot.org/uniprotkb/A6QR22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QR22-1", "url": "https://www.uniprot.org/uniprotkb/A6QR22-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNTLGLAPMGALPRRSPRREEPLPNPGSFDELHRLCKDVFPAQMEGVKLVVNKVLSSHFQVAHTVHMSALGLPGYHLHAAYAGDWQLSPTEVFPTVVGDMDSGGSLNAQVLLLLAERLRAKAVFQTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIVVAHFLQSLTHRLVLGGELVYHRRPGEEGAILTLAGKYSAVHWVATLNVGSGGAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQANMVFRGLVDSNWCVGAVLEKKMPPLPVTLALGAFLNHWRNRFHCGFSITVG", "length": 308, "header": "sp|A6QR22-1|TM40L_BOVIN Isoform 1 of Mitochondrial import receptor subunit TOM40B OS=Bos taurus OX=9913 GN=TOMM40L PE=2 SV=1 CANONICAL=A6QR22-1" }, "isoforms": [ { "isoform_ac": "A6QR22-1", "url": "https://www.uniprot.org/uniprotkb/A6QR22/entry#A6QR22-1", "sequence": { "sequence": "MGNTLGLAPMGALPRRSPRREEPLPNPGSFDELHRLCKDVFPAQMEGVKLVVNKVLSSHFQVAHTVHMSALGLPGYHLHAAYAGDWQLSPTEVFPTVVGDMDSGGSLNAQVLLLLAERLRAKAVFQTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIVVAHFLQSLTHRLVLGGELVYHRRPGEEGAILTLAGKYSAVHWVATLNVGSGGAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQANMVFRGLVDSNWCVGAVLEKKMPPLPVTLALGAFLNHWRNRFHCGFSITVG", "length": 308, "header": "sp|A6QR22-1|TM40L_BOVIN Isoform 1 of Mitochondrial import receptor subunit TOM40B OS=Bos taurus OX=9913 GN=TOMM40L PE=2 SV=1 CANONICAL=A6QR22-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "A6QR22", "url": "https://www.uniprot.org/uniprotkb/A6QR22" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:505393", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505393", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PQQ6-1", "protein_name": "Translocase of outer mitochondrial membrane 40 like", "gene_name": "TOMM40L", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGNAWGPAAPRAPRRGENLGNPGSFDELHRQCKEVFPQQMEGVKLIVNKALSSHFQVTHTVHMSTLGPSNYHFNATFVGDRQLGPTEAFPTLVGDMDNSGSLNAQILHLLAERIRTKAVFQTHQAKFVTWQFDGEYRGDDCTATLTLGNPDLLGGSVILVAHFLQSVTPRLVLGGEMVYHRRPGEEGAILTLAGKYTASNWVATLNVGYGGAHASYYHKANEQVQVGVELEANTRLQDTTFAFGYQLNLPQANVVFRGLLDSNWSVGAVLEKKLPPLPVTLALGAFLNHWKNRFHCGFSVIVG", "length": 303 }, "evidence": [ { "id": "A6QR22", "url": "https://omabrowser.org/oma/group/A6QR22/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8D1IS56-1", "protein_name": "Translocase of outer mitochondrial membrane 40 like", "gene_name": "TOMM40L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGNTLGLAPMGALPRRSPRREEPLPNPGSFDELHRLCKDVFPAQMEGVKLVVNKVLSSHFQVAHTVHMSALGLPGYHLHAAYAGDWQLSPTEVFPTVVGDMDSSGSLNAQVLLLLAERLRAKAVFQTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIMVAHFLQSLTHRLVLGGELVYHRRPGEEGAILTLAGKYSAGHWVATLNVGSGGAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQANMVFRGLVDSNWCVGAVLEKKMPPLPVTLALGAFLNHWRNRFHCGFSITVG", "length": 308 }, "evidence": [ { "id": "A6QR22", "url": "https://omabrowser.org/oma/group/A6QR22/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A4F267-1", "protein_name": "Mitochondrial import receptor subunit TOM40B", "gene_name": "Tomm40l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGNTLGLAPMGTLPRWSHRREEPLPNPGSFDELHRLCKDVFPAQMEGVKLVVNKVLSSHFQVAHTVHMSALGLPGYHLHTAYAGDWQLSPTEVFPTVVGDMDSSGSLNAQVLLLLAERLRAKAVFQTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIMVAHFLQSITHRLVLGGELVYHRRPGEEGAILTLAGKYSALHWVATLNVGSGGAHASYYHKANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQADMVFRGLVDSNWCVGAVLEKKMRPLPVTLALGAFLNHWRNRFHCGFSITVG", "length": 308 }, "evidence": [ { "id": "A6QR22", "url": "https://omabrowser.org/oma/group/A6QR22/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HTY8-1", "protein_name": "Mitochondrial import receptor subunit TOM40B", "gene_name": "Tomm40l", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGNTLGLAPMGTLSRRSPRREEPLPNPGSFDELHRLCKDVFPAQMEGVKLVVNKVLSSHFQVAHTVHMSALGLPGYHLHAAYAGDWQLSPTEVFPTVVGDMDSSGSLNAQVLLLLAERLRAKAIFQTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIMVAHFLQSVTHRLVLGGELVYHRRPGEEGAILTLAGKYSALHWVATLNVGSGGAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQANMVFRGLVDSNWCVGAVLEKKMPPLPVTLALGAFLNHWRNRFHCGFSITVG", "length": 308 }, "evidence": [ { "id": "A6QR22", "url": "https://omabrowser.org/oma/group/A6QR22/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q969M1-1", "protein_name": "Mitochondrial import receptor subunit TOM40B", "gene_name": "TOMM40L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGNTLGLAPMGTLPRRSPRREEPLPNPGSFDELHRLCKDVFPAQMEGVKLVVNKVLSSHFQVAHTIHMSALGLPGYHLHAAYAGDWQLSPTEVFPTVVGDMDSSGSLNAQVLLLLAERLRAKAVFQTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIMVAHFLQSLTHRLVLGGELVYHRRPGEEGAILTLAGKYSAVHWVATLNVGSGGAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQANMVFRGLVDSNWCVGAVLEKKMPPLPVTLALGAFLNHWRNRFHCGFSITVG", "length": 308 }, "evidence": [ { "id": "A6QR22", "url": "https://omabrowser.org/oma/group/A6QR22/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CZR3-1", "protein_name": "Mitochondrial import receptor subunit TOM40B", "gene_name": "Tomm40l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGNTLGLAPMGTLPRRSHRREEPLPNPGSFDELHRLCKDVFPAQMEGVKLVVNKVLSSHFQVAHTVHMSALGLPGYHLHTAYAGDWQLSPTEVFPTVVGDMDSSGSLNAQVLLLLAERLRAKAVFQTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIMVAHFLQSITHRLVLGGELVYHRRPGEEGAILTLAGKYSAVHWVATLNVGSGGAHASYYHKANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQADMVFRGLVDSNWCVGAVLEKKMRPLPVTLALGAFLNHWRNRFHCGFSITVG", "length": 308 }, "evidence": [ { "id": "A6QR22", "url": "https://omabrowser.org/oma/group/A6QR22/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial outer membrane translocase complex", "id": "GO:0005742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005742", "evidence": [ { "database": "UniProtKB", "id": "A6QR22", "url": "https://www.uniprot.org/uniprotkb/A6QR22" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein import into mitochondrial matrix", "id": "GO:0030150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030150", "evidence": [ { "database": "UniProtKB", "id": "A6QR22", "url": "https://www.uniprot.org/uniprotkb/A6QR22" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein transmembrane transporter activity", "id": "GO:0008320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008320", "evidence": [ { "database": "UniProtKB", "id": "A6QR22", "url": "https://www.uniprot.org/uniprotkb/A6QR22" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QR22-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 308, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QR22-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QR22" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "E1B7Q0-1", "uniprot_ac": "E1B7Q0", "uniprot_id": "E1B7Q0_BOVIN", "mass": { "chemical_mass": 83146.0, "monoisotopic_mass": 83146.0 }, "refseq": { "ac": "NP_001179529", "name": "protein Hook homolog 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179529" }, "gene_names": [ { "name": "HOOK3", "type": "recommended", "evidence": [ { "id": "E1B7Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ] }, { "name": "HOOK3", "type": "synonym", "evidence": [ { "id": "NP_001179529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179529" } ] } ], "protein_names": [ { "name": "Hook microtubule tethering protein 3", "type": "synonym", "evidence": [ { "id": "E1B7Q0", "database": "UniProtKB", "url": 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"Ensembl Gene", "id": "ENSBTAG00000007634", "url": "https://www.ensembl.org/id/ENSBTAG00000007634" } ] } } ], "crossref": [ { "id": "E1B7Q0", "url": "https://alphafold.ebi.ac.uk/entry/E1B7Q0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007634", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007634", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22226", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22226", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "524648", "url": "https://www.ncbi.nlm.nih.gov/gene/524648", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008636", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008636", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": 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"id": "PTHR18947", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18947", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18947:SF38", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18947:SF38", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19047", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19047", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179529", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LF92", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LF92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LF92-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LF92-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTM2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTM2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7Q0-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFNVETLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIAEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMVMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTSEELNEALSAKEEIAQRCHELDLQVAALQEEKSSLLVENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADDAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRSERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKINQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRQFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSTRRSYPGHVQPATAR", "length": 718, "header": "tr|E1B7Q0-1|E1B7Q0_BOVIN Isoform 1 of Hook microtubule tethering protein 3 OS=Bos taurus OX=9913 GN=HOOK3 PE=3 SV=1 CANONICAL=E1B7Q0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LF92-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0/entry#A0A3Q1LF92-1", "sequence": { "sequence": "MFNVETLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIAEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMVMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTSEELNEALSAKEEIAQRCHELDLQVAALQEEKSSLLVENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADDAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRSERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKINQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRQFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSTRRSYPGHVQPATASFFIIACT", "length": 725, "header": "tr|A0A3Q1LF92-1|E1B7Q0_BOVIN Computationally mapped isoform of Hook microtubule tethering protein 3 OS=Bos taurus OX=9913 GN=HOOK3 PE=3 SV=2 CANONICAL=E1B7Q0-1" }, "locus": { "chromosome": "27", "start_pos": 37676627, "end_pos": 37591245, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082006.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082006.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056780.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056780.2" } ] } }, { "isoform_ac": "A0A3Q1LTM2-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0/entry#A0A3Q1LTM2-1", "sequence": { "sequence": "MFNVETLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIAEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMVMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTSEELNEALSAKEEIAQRCHELDLQVAALQEEKSSLLVENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADDAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRSERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKINQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDAISVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRQFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSTRRSYPGHVQPATAR", "length": 720, "header": "tr|A0A3Q1LTM2-1|E1B7Q0_BOVIN Computationally mapped isoform of Hook microtubule tethering protein 3 OS=Bos taurus OX=9913 GN=HOOK3 PE=3 SV=3 CANONICAL=E1B7Q0-1" }, "locus": { "chromosome": "27", "start_pos": 37670171, "end_pos": 37591245, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074714.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074714.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060426.3", "url": "https://www.ensembl.org/id/ENSBTAP00000060426.3" } ] } }, { "isoform_ac": "E1B7Q0-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0/entry#E1B7Q0-1", "sequence": { "sequence": "MFNVETLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIAEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMVMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTSEELNEALSAKEEIAQRCHELDLQVAALQEEKSSLLVENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADDAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRSERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKINQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRQFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSTRRSYPGHVQPATAR", "length": 718, "header": "tr|E1B7Q0-1|E1B7Q0_BOVIN Isoform 1 of Hook microtubule tethering protein 3 OS=Bos taurus OX=9913 GN=HOOK3 PE=3 SV=1 CANONICAL=E1B7Q0-1" }, "locus": { "chromosome": "27", "start_pos": 37670171, "end_pos": 37591245, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010044.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010044.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010044.4", "url": "https://www.ensembl.org/id/ENSBTAP00000010044.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:524648", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524648", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZWS4-1", "protein_name": "Protein Hook homolog 3", "gene_name": "Hook3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFNVESVERVELCESLLTWIQTFNVDTPCQTVEDLTNGVVMSQVLQKIDPAYFDDNWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQILMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARGQLETYKRQVVELQNRLSDESKKADKLDFEYKRLKEKVDGLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKINQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLRIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKTQRDMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSTRRSYPGHVQPATARSCSSRML", "length": 725 }, "evidence": [ { "id": "E1B7Q0", "url": "https://omabrowser.org/oma/group/E1B7Q0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0Y7B7-1", "protein_name": "Protein Hook homolog 3", "gene_name": "HOOK3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MFNVESLERAELGESLLTWIQTFNVEAPCQTVEDLTSGVVMAQVLQKIDPVYFDENWLNRIKTEVGDNWRLKVSNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHADAAELGRMLQLILGCAVNCEQKQEYIQTIMMMEESVQHMVMAAIQELMSKESPVSVGNDAYVDLDRQLKKTTEELNEALSTKEEIAQRCHELDMQVAALQEEKSSLLAENQILMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEIAELRQQTEELTALAEEAQSLKDEIDVLRHSSDKVAKLESQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQAVELQNRLSEESKKADKLDYECKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTTGLMPLGRQEPSDSLAAEIVTPEIKEKLIRLQHENKILKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQDSKAEDAISVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRCNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRMFHSLEKEYEKTKNQREMEEKFIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSTRRSYPGHVQPATASDVVA", "length": 724 }, "evidence": [ { "id": "E1B7Q0", "url": "https://omabrowser.org/oma/group/E1B7Q0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q24185-1", "protein_name": "Protein hook", "gene_name": "hook", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSAPKNEMYYSLLEWFKTLNLNAPHADAESLADGVALAQALNQFAPESFTDAWLSKIKASAVGSNWRLRMSNLKKVTQSVYDYYSDVLNYSLSDFSKPDLQRIAEKCDLGELERLLQLVLGCAVNCAEKQSYITEIMCLEEELQANIMRALQELEATRQASTPEGGVASSLSRGSRTGLLDSKAVQEDRDALAQKCFETEKKMLLLIDEKTNLQQELHKLQQEFARLEQHSTVIGDDGVSLGPVQTGSVRYNELRRQLDLLKEELLQSEGAREDLKIKAQQQDTDLLHMQMRIEELMKSSAEVTTLKDEVDVLRESNDKLKICEAQLDTYKKKLEDYNDLKKQVKILEERSADYVQQNAQFEEDAKRYANTKGQVELFKKEIQDLHAKLDAESSKNVKLEFDNKNLESKNLALQRAKDSLLKERDNLREAVDELKCGQLSSNTALTGTTVSRELQPSATVEKLQRLEAENKALREGQGGQTALAQLLDDANKRCENLREQLKTANERILSLSHASQSDDPILKESEFGKQIKQLMELNEQKTLQLEEAVTQSTSLQCKVTQLETNLSAREQEILVYDAKYRKCVEKAKEVIKSIDPRIASALDASVLEKSADLVEEEPKPKMSVMEEQLMTSAFYRLGVNAQRDAIDSKLAILMGSGQTFLARQRQSAPRKSLSAMKSK", "length": 679 }, "evidence": [ { "id": "E1B7Q0", "url": "https://omabrowser.org/oma/group/E1B7Q0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q54IK9-1", "protein_name": "Protein hook homolog", "gene_name": "hook", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIETSFIKWINSFKDLSNSIEDLKELSNGTIFNEICCQIAPKYFDIDSLRKDGLDNWIFREENIKNIVERVDEFYIEEMGLNDQISSINCEEIANENIDEIILLIEAILGMAMESENNEAVIENILSLDQDTQNDLMVVVAKIQQSHQPNTVDNSKSFDKDGSILSQSPSQSNNSISNNNNNNNIDSSNISKSNISSNNNNNNSSNNNKEEILNLQNEIEKLKREKQEIQNDLDESNIQLSNVTMDRDRITIDKQKTEEVCSSLHESIIGLQKQLDETMAQTTTMNALNDETYKTEINDLHMQVESKEKQLSELKKKVDEANRLANENRSLRDEIDILREKAANAEATEEKLKKHQKKIEEIGDLKKKIKELEDQNDSYIQQTLDLEEQLSKNNTYRTQADSGKQQISSLKIELAKLELSLKSIKEDRDKLSESLNTVELERDSLQSQVTNLRNTIDNQQQEYETKFVDLQSSISLNSGGSGGLGDEVIDGSTKERIARLERDNKRLKEVAEKASELENQLEDANQSKELLTIQIKQLEEQKQQSNNTNNNNNNNNMVDSSEIESLKQQLKEKEKEISTLKRKLEESNLSLDENRKQLVELSQRPTTQSPGDIEKLENYENLLKENDGLEGRLRAARNIIKDLREKHKSYSNQETQLATKDEVITKLEGLVKKKTDINEDLRKQLEEGREESQREINLMLSAFLKIGLEMEQVKIQNISSSKEPRSFLNKKRAD", "length": 734 }, "evidence": [ { "id": "E1B7Q0", "url": "https://omabrowser.org/oma/group/E1B7Q0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q86VS8-1", "protein_name": "Protein Hook homolog 3", "gene_name": "HOOK3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSSRRSYPGHVQPATAR", "length": 718 }, "evidence": [ { "id": "E1B7Q0", "url": "https://omabrowser.org/oma/group/E1B7Q0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BUK6-1", "protein_name": "Protein Hook homolog 3", "gene_name": "Hook3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFNVESVERVELCESLLTWIQTFNVDAPCQTAEDLTNGVVMSQVLQKIDPVYFDDNWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGHDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQILMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARGQLETYKRQVVELQNRLSDESKKADKLDFEYKRLKEKVDGLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEDSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLRIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQRDMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSTRRSYPGHVQPATAR", "length": 718 }, "evidence": [ { "id": "E1B7Q0", "url": "https://omabrowser.org/oma/group/E1B7Q0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "HOPS complex", "id": "GO:0030897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030897", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "FHF complex", "id": "GO:0070695", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070695", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "cis-Golgi network", "id": "GO:0005801", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005801", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "centriolar satellite", "id": "GO:0034451", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034451", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "pericentriolar material", "id": "GO:0000242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000242", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "dynactin binding", "id": "GO:0034452", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034452", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "dynein light chain binding", "id": "GO:0045503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045503", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "dynein intermediate chain binding", "id": "GO:0045505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045505", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "dynein light intermediate chain binding", "id": "GO:0051959", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051959", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "endosome organization", "id": "GO:0007032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007032", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "lysosome organization", "id": "GO:0007040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007040", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "endosome to lysosome transport", "id": "GO:0008333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008333", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "early endosome to late endosome transport", "id": "GO:0045022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045022", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "negative regulation of neurogenesis", "id": "GO:0050768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050768", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "cytoskeleton-dependent intracellular transport", "id": "GO:0030705", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030705", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "protein localization to perinuclear region of cytoplasm", "id": "GO:1905719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905719", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "protein localization to centrosome", "id": "GO:0071539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071539", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "cytoplasmic microtubule organization", "id": "GO:0031122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031122", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "Golgi localization", "id": "GO:0051645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051645", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" }, { "name": "interkinetic nuclear migration", "id": "GO:0022027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022027", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q0", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" }, { "start_pos": 577, "end_pos": 579, "annotation": "n_glycosylation_sequon" }, { "start_pos": 578, "end_pos": 580, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q0" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 10, "end_pos": 126, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 228, "end_pos": 230 }, { "start_pos": 577, "end_pos": 579 }, { "start_pos": 578, "end_pos": 580 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", 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[ "Protein" ] }, { "id": "A0A3Q1NK18", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NK18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NK18-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NK18-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0G7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0G7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0G7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0G7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH04-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDI0", "url": "https://www.uniprot.org/uniprotkb/E1BDI0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDI0-1", "url": "https://www.uniprot.org/uniprotkb/E1BDI0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGVCRGRRKFLAASLTLLCIPAITWLYLFAGSFEDGKPVSLSPLEAQPHSPRYTASSQRERESLEVRVREVEEENRALRRQLSLAQGRSPSHRRGNHSKTYSMEEGTGDSENLHAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPASDNTDVTLVAQLSMDRLQMLEAICKHWEGPVSLALYLSDAEAQQFLRYAQGSEVLMGRHNVAYHIVYKEGQFYPVNLLRNVAMKHVGTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDAQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 756, "header": "tr|E1BDI0-1|E1BDI0_BOVIN Isoform 1 of LARGE xylosyl- and glucuronyltransferase 1 OS=Bos taurus OX=9913 GN=LARGE1 PE=3 SV=2 CANONICAL=E1BDI0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MIH0-1", "url": "https://www.uniprot.org/uniprotkb/E1BDI0/entry#A0A3Q1MIH0-1", "sequence": { "sequence": "MLGVCRGRRKFLAASLTLLCIPAITWLYLFAGSFEDGKPVSLSPLEAQPHSPRYTASSQRERESLEVRVREVEEENRALRRQLSLAQGRSPSHRRGNHSKTYSMEEGTGDSENLHAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPASDNTDVTLVAQLSMDSLDSSQTLSPNVSCKTTFPERCL", "length": 506, "header": "tr|A0A3Q1MIH0-1|E1BDI0_BOVIN Computationally mapped isoform of LARGE xylosyl- and glucuronyltransferase 1 OS=Bos taurus OX=9913 GN=LARGE1 PE=3 SV=1 CANONICAL=E1BDI0-1" }, "locus": { "chromosome": "5", "start_pos": 72260619, "end_pos": 71712065, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066633.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066633.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070511.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070511.2" } ] } }, { "isoform_ac": "A0A3Q1N5D2-1", "url": "https://www.uniprot.org/uniprotkb/E1BDI0/entry#A0A3Q1N5D2-1", "sequence": { "sequence": "MLGVCRGRRKFLAASLTLLCIPAITWLYLFAGSFEDGKPVSLSPLEAQPHSPRYTASSQRERESLEVRVREVEEENRALRRQLSLAQGRSPSHRRGNHSKTYSMEEGTGDSENLHAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPASDNTDVTLVAQLSMDRLQMLEAICKHWEGPVSLALYLSDAEAQQFLRYAQGSEVLMGRHNVAYHIVYKEGQFYPVNLLRNVAMKHVGTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFSLDSSQTLSPNVSCKTTFPERCL", "length": 648, "header": "tr|A0A3Q1N5D2-1|E1BDI0_BOVIN Computationally mapped isoform of LARGE xylosyl- and glucuronyltransferase 1 OS=Bos taurus OX=9913 GN=LARGE1 PE=3 SV=1 CANONICAL=E1BDI0-1" }, "locus": { "chromosome": "5", "start_pos": 72260619, "end_pos": 71712065, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083913.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083913.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065361.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065361.2" } ] } }, { "isoform_ac": "A0A3Q1NK18-1", "url": "https://www.uniprot.org/uniprotkb/E1BDI0/entry#A0A3Q1NK18-1", "sequence": { "sequence": "MLGVCRGRRKFLAASLTLLCIPAITWLYLFAGSFEDGKPVSLSPLEAQPHSPRYTASSQRERESLEVRVREVEEENRALRRQLSLAQGRSPSHRRGNHSKTYSMEEGTGDSENLHAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPASDNTDVTLVAQLSMDRLQMLEAICKHWEGPVSLALYLSDAEAQQFLRYAQGSEVLMGRHNVAYHIVYKEGQFYPVNLLRNVAMKHVGTPYMFLSDIDFLPMYGLYEYLSLDSSQTLSPNVSCKTTFPERCL", "length": 599, "header": "tr|A0A3Q1NK18-1|E1BDI0_BOVIN Computationally mapped isoform of LARGE xylosyl- and glucuronyltransferase 1 OS=Bos taurus OX=9913 GN=LARGE1 PE=3 SV=2 CANONICAL=E1BDI0-1" }, "locus": { "chromosome": "5", "start_pos": 72260619, "end_pos": 71712065, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079239.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079239.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072585.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072585.2" } ] } }, { "isoform_ac": "A0AAA9S0G7-1", "url": "https://www.uniprot.org/uniprotkb/E1BDI0/entry#A0AAA9S0G7-1", "sequence": { "sequence": "MLGVCRGRRKFLAASLTLLCIPAITWLYLFAGSFEDGKPVSLSPLEAQPHSPRYTASSQRERESLEVRVREVEEENRALRRQLSLAQGRSPSHRRGNHSKTYSMEEGTGDSENLHAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPASDNTDVTLVAQLSMDRLQMLEAICKHWEGPVSLALYLSDAEAQQFLRYAQGSEVLMGRHNVAYHIVYKEGQFYPVNLLRNVAMKHVGTPYMFLSDIDFLPMYGLYEYLRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDAQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 707, "header": "tr|A0AAA9S0G7-1|E1BDI0_BOVIN Computationally mapped isoform of LARGE xylosyl- and glucuronyltransferase 1 OS=Bos taurus OX=9913 GN=LARGE1 PE=3 SV=1 CANONICAL=E1BDI0-1" }, "locus": { "chromosome": "5", "start_pos": 72260619, "end_pos": 71807544, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116909.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116909.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077132.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077132.1" } ] } }, { "isoform_ac": "A0AAA9SH04-1", "url": "https://www.uniprot.org/uniprotkb/E1BDI0/entry#A0AAA9SH04-1", "sequence": { "sequence": "MLGVCRGRRKFLAASLTLLCIPAITWLYLFAGSFEDGKPVSLSPLEAQPHSPRYTASSQRERESLEVRVREVEEENRALRRQLSLAQGRSPSHRRGNHSKTYSMEEGTGDSENLHAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPASDNTDVTLVAQLSMDRLQMLEAICKHWEGPVSLALYLSDAEAQQFLRYAQGSEVLMGRHNVAYHIVYKEGQFYPVNLLRNVAMKHVGTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDAQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 704, "header": "tr|A0AAA9SH04-1|E1BDI0_BOVIN Computationally mapped isoform of LARGE xylosyl- and glucuronyltransferase 1 OS=Bos taurus OX=9913 GN=LARGE1 PE=3 SV=1 CANONICAL=E1BDI0-1" }, "locus": { "chromosome": "5", "start_pos": 72260619, "end_pos": 71807544, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114244.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114244.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082974.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082974.1" } ] } }, { "isoform_ac": "A0AAA9TAM4-1", "url": "https://www.uniprot.org/uniprotkb/E1BDI0/entry#A0AAA9TAM4-1", "sequence": { "sequence": "MLGVCRGRRKFLAASLTLLCIPAITWLYLFAGSFEDGKPVSLSPLEAQPHSPRYTASSQRERESLEVRVREVEEENRALRRQLSLAQGRSPSHRRGNHSKTYSMEEGTGDSENLHAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPASDNTDVTLVAQLSMDRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDAQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 663, "header": "tr|A0AAA9TAM4-1|E1BDI0_BOVIN Computationally mapped isoform of LARGE xylosyl- and glucuronyltransferase 1 OS=Bos taurus OX=9913 GN=LARGE1 PE=3 SV=1 CANONICAL=E1BDI0-1" }, "locus": { "chromosome": "5", "start_pos": 72260619, "end_pos": 71807544, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092340.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092340.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093064.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093064.1" } ] } }, { "isoform_ac": "A0AAA9TNJ8-1", "url": "https://www.uniprot.org/uniprotkb/E1BDI0/entry#A0AAA9TNJ8-1", "sequence": { "sequence": "MLGVCRGRRKFLAASLTLLCIPAITWLYLFAGSFEDGKPVSLSPLEAQPHSPRYTASSQRERESLEVRVREVEEENRALRRQLSLAQGRSPSHRRGNHSKTYSMEEGTGDSENLHAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPASDNTDVTLVAQLSMDRLQMLEAICKHWEGPVSLALYLSDAEAQQFLRYAQGSEVLMGRHNVAYHIVYKEGQFYPVNLLRNVAMKHVGTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDAQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 714, "header": "tr|A0AAA9TNJ8-1|E1BDI0_BOVIN Computationally mapped isoform of LARGE xylosyl- and glucuronyltransferase 1 OS=Bos taurus OX=9913 GN=LARGE1 PE=3 SV=1 CANONICAL=E1BDI0-1" }, "locus": { "chromosome": "5", "start_pos": 72260619, "end_pos": 71807544, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129466.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129466.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100112.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100112.1" } ] } }, { "isoform_ac": "E1BDI0-1", "url": "https://www.uniprot.org/uniprotkb/E1BDI0/entry#E1BDI0-1", "sequence": { "sequence": "MLGVCRGRRKFLAASLTLLCIPAITWLYLFAGSFEDGKPVSLSPLEAQPHSPRYTASSQRERESLEVRVREVEEENRALRRQLSLAQGRSPSHRRGNHSKTYSMEEGTGDSENLHAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPASDNTDVTLVAQLSMDRLQMLEAICKHWEGPVSLALYLSDAEAQQFLRYAQGSEVLMGRHNVAYHIVYKEGQFYPVNLLRNVAMKHVGTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDAQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 756, "header": "tr|E1BDI0-1|E1BDI0_BOVIN Isoform 1 of LARGE xylosyl- and glucuronyltransferase 1 OS=Bos taurus OX=9913 GN=LARGE1 PE=3 SV=2 CANONICAL=E1BDI0-1" }, "locus": { "chromosome": "5", "start_pos": 72260619, "end_pos": 71807544, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029269.7", "url": "https://www.ensembl.org/id/ENSBTAT00000029269.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029269.6", "url": "https://www.ensembl.org/id/ENSBTAP00000029269.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506466", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506466", "resource": "KEGG Pathway" }, { "id": "R-BTA-9939291", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9939291", "resource": "Reactome", "description": "Matriglycan biosynthesis on DAG1" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K618-1", "protein_name": "LARGE xylosyl- and glucuronyltransferase 1", "gene_name": "Large1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLGICRGRRKFLAASLTLLCIPALTWIYLFAGSLEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRVREVEEENRALRRQLSLAQGQSPAHRRGNHSKTYSMEEGTGDSENQRAGIVAGNSSECGQQPAVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSETDVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEFEPSADHTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRQNVGYHIVYKEGQFYPVNFLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYQVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDAQEYEFTVLPNAYMIHMPHAPSFDITKFRSNKQYRVCLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 756 }, "evidence": [ { "id": "E1BDI0", "url": "https://omabrowser.org/oma/group/E1BDI0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A480F6A1-1", "protein_name": "LARGE xylosyl- and glucuronyltransferase 1", "gene_name": "LARGE1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLGICRGRRKFLAASLTLLCIPAITWLYLFAGSLEDGKPVSLSPLESQPHSPRYTASSQRDRESLELRMREVEEENRALRRQLSLAQGRGHRRGNHSRTYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPAKLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPASDNTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMGRHNVAYHIVYKEGQFYPVNLLRNVAMKHVGTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDAQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 754 }, "evidence": [ { "id": "E1BDI0", "url": "https://omabrowser.org/oma/group/E1BDI0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HN56-1", "protein_name": "LARGE xylosyl- and glucuronyltransferase 1 isoform X1", "gene_name": "Large1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLGICRGRRKFLAASLSLLCIPAITWIYLFAGSFEDGKPVSLSPLESQAHSPRYTASSQRDRESLEVRVREVEEENRSLRRQLSLAQGQVPVHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPAVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSETDVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEFEPATDNTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATMPYRVEWEADFEPYVVVRRDCSEYDRRFVGFGWNKVAHIMELDAQEYEFTVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 756 }, "evidence": [ { "id": "E1BDI0", "url": "https://omabrowser.org/oma/group/E1BDI0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O95461-1", "protein_name": "Xylosyl- and glucuronyltransferase LARGE1", "gene_name": "LARGE1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLGICRGRRKFLAASLSLLCIPAITWIYLFSGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRMREVEEENRALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDVQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 756 }, "evidence": [ { "id": "E1BDI0", "url": "https://omabrowser.org/oma/group/E1BDI0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q66PG2-1", "protein_name": "Xylosyl- and glucuronyltransferase LARGE1", "gene_name": "large1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLGMCRGRRKFVAASLALIFIPALTWLYLSSANITVKPLPLSPLDPQSSAVVGAAAEHQSLELRLRDVEEHNNALRREISRTPRVPTHSSHPSSSRHGNQLHTHSTEEGTGDSEAKKGAAAGNSSDCVPQPVVKKCETIHIAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHIITDSIARKILADLFHTWMVPAVHVNFYDADELKSEVSWIPNKHYSGIHGLMKLVLTKTLPSDLEKVIVLDTDITFATDIAELWVVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGFNTGVILLLLDRLRKLKWEQMWRLTAERELMSMLSTSLADQDIFNAVIKQNPFLVHQLPCYWNVQLSDHTRSEKCYKDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSETDHNSENLQKTLSELDEDDPCYEFRRERFTVHRTHVYFLHYEYEPTVDNTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRSNVGYHIVYKEGQFYPVNLLRNVAMGQVNTPYMFLSDIDFLPMYGLYEYLRKSVVQLDMGNTKKALVVPAFETLRYRLSFPKSKAELLSQLDMGTLFTFRYHVWTKGHAPTDFAKWRTATTPYRVQWEADFEPYVMVRRESPEYDRRFVGFGWNKVAHIMELDAQEYEFVVLPNAYMIHMPHAPSFDITKFRSNKQYRACLKTLKEEFQQNMSRRYGFAALKYMTVDNNS", "length": 757 }, "evidence": [ { "id": "E1BDI0", "url": "https://omabrowser.org/oma/group/E1BDI0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9Z1M7-1", "protein_name": "Xylosyl- and glucuronyltransferase LARGE1", "gene_name": "Large1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLGICRGRRKFLAASLTLLCIPAITWIYLFAGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRVREVEEENRALRRQLSLAQGQSPAHHRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPAVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSETDVNNENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEFEPSADNTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRQNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYQVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDAQEYEFTVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS", "length": 756 }, "evidence": [ { "id": "E1BDI0", "url": "https://omabrowser.org/oma/group/E1BDI0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "UDP-glycosyltransferase activity", "id": "GO:0008194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008194", "evidence": [ { "database": "UniProtKB", "id": "E1BDI0", "url": "https://www.uniprot.org/uniprotkb/E1BDI0" } ], "pmid": "" }, { "name": "xylosyltransferase activity", "id": "GO:0042285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042285", "evidence": [ { "database": "UniProtKB", "id": "E1BDI0", "url": "https://www.uniprot.org/uniprotkb/E1BDI0" } ], "pmid": "" }, { "name": "manganese ion binding", "id": "GO:0030145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030145", "evidence": [ { "database": "UniProtKB", "id": "E1BDI0", "url": "https://www.uniprot.org/uniprotkb/E1BDI0" } ], "pmid": "" }, { "name": "glucuronosyltransferase activity", "id": "GO:0015020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015020", "evidence": [ { "database": "UniProtKB", "id": "E1BDI0", "url": "https://www.uniprot.org/uniprotkb/E1BDI0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "E1BDI0", "url": "https://www.uniprot.org/uniprotkb/E1BDI0" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "E1BDI0", "url": "https://www.uniprot.org/uniprotkb/E1BDI0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein O-linked glycosylation via mannose", "id": "GO:0035269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035269", "evidence": [ { "database": "UniProtKB", "id": "E1BDI0", "url": "https://www.uniprot.org/uniprotkb/E1BDI0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 754, "end_pos": 756, "annotation": "n_glycosylation_sequon" }, { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "57336", "name": "", "equation": "3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "57336", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/57336" } ] }, { "id": "67924", "name": "", "equation": "3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate = 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "67924", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67924" } ] }, { "id": "68368", "name": "", "equation": "3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose = 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "68368", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/68368" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDI0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 756, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDI0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDI0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 122, "end_pos": 124 }, { "start_pos": 148, "end_pos": 150 }, { "start_pos": 272, "end_pos": 274 }, { "start_pos": 754, "end_pos": 756 }, { "start_pos": 97, "end_pos": 99 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BBM3-1", "uniprot_ac": "E1BBM3", "uniprot_id": "E1BBM3_BOVIN", "mass": { "chemical_mass": 140464.0, "monoisotopic_mass": 140464.0 }, "refseq": { "ac": "XP_010805977", "name": "serine/threonine-protein kinase Nek1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805977" }, "gene_names": [ { "name": "NEK1", "type": "recommended", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "name": "NEK1", "type": "synonym", "evidence": [ { "id": "XP_010805977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805977" } ] } ], "protein_names": [ { "name": "non-specific serine/threonine protein kinase", "type": "recommended", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3/entry#names_and_taxonomy" } ] }, { "name": "serine/threonine-protein kinase Nek1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010805977", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805977" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBM3", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NEK1", "url": "https://www.uniprot.org/uniprotkb/E1BBM3", "locus": { "chromosome": "8", "start_pos": 1385879, "end_pos": 1531752, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026915", "url": "https://www.ensembl.org/id/ENSBTAG00000026915" } ] } } ], "crossref": [ { "id": "E1BBM3", "url": "https://alphafold.ebi.ac.uk/entry/E1BBM3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000026915", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026915", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08218", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08218", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534671", "url": "https://www.ncbi.nlm.nih.gov/gene/534671", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534671", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534671", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ELNEEWH", "url": "https://omabrowser.org/oma/group/ELNEEWH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MCY1", "url": "https://www.orthodb.org/?gene=A0A3Q1MCY1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N5Y0", "url": "https://www.orthodb.org/?gene=A0A3Q1N5Y0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BBM3", "url": "https://www.orthodb.org/?gene=E1BBM3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44899", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44899", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44899:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44899:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9861718", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9861718", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010805977", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805977", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MCY1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCY1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCY1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N5Y0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5Y0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N5Y0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5Y0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8F9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8F9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8F9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8F9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T045", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T045", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T045-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T045-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA14-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIU9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIU9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSB6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSB6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBM3", "url": "https://www.uniprot.org/uniprotkb/E1BBM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBM3-1", "url": "https://www.uniprot.org/uniprotkb/E1BBM3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKYIRVQKIGEGSFGKAILVRSTEDGRQYVIKEINISRMSNKEREESRREVAVLANMRHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTRDGTIQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIISGSFPPVSLHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGAQPLPAKRPASGQSLASIMSAQKITKPAAKYGIPLTNKKYIDKKLHERKPLQKYKQAHQTPVKKVNPGEERRKLFEEAPRKRRLELTEKEKKSKDQVSLLKAEQVKRQEKQRLERINRAREQGWRNVLSAGGSGEMKAPLLGSGGAMAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKGEIHGQRLPERQKGQPAMERAKQVEEFLQRRREAKQNKARAEGHMGILHNLAALYGGRPSSSRGGKPRNKEEEVYLARLRQIRLQNFNERQQIRAKLRGEKKETDSSEDQEGSEEADVRRKKVEALKAQASARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGIKNSDVSPPSGQQEMGGSPTKQPMRPVISVTSALKEVCMDQSLTDAQETSEEMQKSNSAVSSKREILRRLNQNLKVQENEKGRQSRRETGTVTVHEDAKELEKEKSVVSDRKKWETGGQLVLPVDELALDASFSVTEKHIVGEVIKLDPSGSPRKVWGKSPTDSVLRILGEAELQLQTELLENTSIRNEISPESENFKSLITEEEKVKCIPLEMNPPATLDSSVETNSPNISEASPQTALKAEGDLEEPDDLEAEVLQEPSGADRDGGLPQPVLDMWVTEREGAEEVELEDRITIQQNELSEDKAPSSVDHLSEVHVEPGVDDSPPSKRDIDKSMQPEPFFHKVVYSEHLKAVSQVQSVLCSPEESFPLRSHSDSPPRNKKQNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDGRQDNLEMEDEHVKEGPSDSEDIVFEEADTDLQELQASMEQLLQEQPGEDYSEEEESGLKTSDDAEQAANGTDAGEEDDNPSSESALNEEWHSDNSDGEITSECEYDSVFNHLEELRLHLEQEIGFEKFFEVYEKIKAVHEDEDENIEICSTIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE", "length": 1239, "header": "tr|E1BBM3-1|E1BBM3_BOVIN Isoform 1 of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=NEK1 PE=3 SV=3 CANONICAL=E1BBM3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MCY1-1", "url": "https://www.uniprot.org/uniprotkb/E1BBM3/entry#A0A3Q1MCY1-1", "sequence": { "sequence": "MEKYIRVQKIGEGSFGKAILVRSTEDGRQYVIKEINISRMSNKEREESRREVAVLANMRHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTRDGTIQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIISGSFPPVSLHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGAQPLPAKRPASGQSLASIMSAQKITKPAAKYGIPLTNKKYIDKKLHERKPLQKYKQEAPRKRRLELTEKEKKSKDQVSLLKAEQVKRQEKQRLERINRAREQGWRNVLSAGGSGEMKAPLLGSGGAMAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKGEIHGQRLPERQKGQPAMERAKQVEEFLQRRREAKQNKARAEGHMVYLARLRQIRLQNFNERQQIRAKLRGEKKETDSSEDQEGSEEADVRRKKVEALKAQASARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGIKNSDVSPPSGQQEMGGSPTKQPMRPVISVTSALKEVCMDQSLTDAQETSEEMQKSNSAVSSKREILRRLNQNLKVQENEKGRQSRRETGTVTVHEDAKELEKEKSVVSDRKKWETGGQLVLPVDELALDASFSVTEKHIVGEVIKLDPSGSPRKVWGKSPTDSVLRILGEAELQLQTELLENTSIRNEISPESENFKSLITEEEKVKCIPLEMNPPATLDSSVETNSPNISEASPQTALKAEGDLEEPDDLEAEVLQEPSGADRDGGLPQPVLDMWVTEREGAEEVELEDRITIQQNELSEDKAPSSVDHLSEVHVEPGVDDSPPSKRDIDKSMQPEPFFHKVVYSEHLKAVSQVQSVLCSPEESFPLRSHSDSPPRNKKQNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDGRQDNLEMEDEHVKEGPSDSEDIVFEEADTDLQELQASMEQLLQEQPGEDYSEEEESGLKTSDDAEQAANGTDAGEEDDNPSSESALNEEWHSDNSDGEITSECEYDSVFNHLEELRLHLEQEIGFEKFFEVYEKIKAVHEDEDENIEICSTIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE", "length": 1191, "header": "tr|A0A3Q1MCY1-1|E1BBM3_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=NEK1 PE=3 SV=2 CANONICAL=E1BBM3-1" }, "locus": { "chromosome": "8", "start_pos": 1528177, "end_pos": 1400051, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084067.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084067.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072011.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072011.2" } ] } }, { "isoform_ac": "A0A3Q1N5Y0-1", "url": "https://www.uniprot.org/uniprotkb/E1BBM3/entry#A0A3Q1N5Y0-1", "sequence": { "sequence": "MEKYIRVQKIGEGSFGKAILVRSTEDGRQYVIKEINISRMSNKEREESRREVAVLANMRHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTRDGTIQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIISGSFPPVSLHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGAQPLPAKRPASGQSLASIMSAQKITKPAAKYGIPLTNKKYIDKKLHERKPLQKYKQAHQTPVKKVNPGEERRKLFEEAPRKRRLELTEKEKKSKDQVSLLKAEQVKRQEKQRLERINRAREQGWRNVLSAGGSGEMKAPLLGSGGAMAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKGEIHGQRLPERQKGQPAMERAKQVEEFLQRRREAKQNKARAEGHMVYLARLRQIRLQNFNERQQIRAKLRGEKKETDSSEDQEGSEEADVRRKKVEALKAQASARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGIKNSDVSPPSGQQEMGGSPTKQPMRPVISVTSALKEVCMDQSLTDAQETSEEMQKSNSAVSSKREILRRLNQNLKVQENEKGRQSRRETGTVTVHEDAKELEKEKSVVSDRKKWETGGQLVLPVDELALDASFSVTEKHIVGEVIKLDPSGSPRKVWGKSPTDSVLRILGEAELQLQTELLENTSIRNEISPESENFKSLITEEEKVKCIPLEMNPPATLDSSVETNSPNISEASPQTALKAEGDLEEPDDLEAEVLQEPSGADRDGGLPQPVLDMWVTEREGAEEVELEDRITIQQNELSEDKAPSSVDHLSEVHVEPGVDDSPPSKRDIDKSMQPEPFFHKVVYSEHLKAVSQVQSVLCSPEESFPLRSHSDSPPRNKKQNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDGRQDNLEMEDEHVKEGPSDSEDIVFEEADTDLQELQASMEQLLQEQPGEDYSEEEESGLKTSDDAEQAANGTDAGEEDDNPSSESALNEEWHSDNSDGEITSECEYDSVFNHLEELRLHLEQEIGFEKFFEVYEKIKAVHEDEDENIEICSTIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE", "length": 1211, "header": "tr|A0A3Q1N5Y0-1|E1BBM3_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=NEK1 PE=3 SV=1 CANONICAL=E1BBM3-1" }, "locus": { "chromosome": "8", "start_pos": 1528177, "end_pos": 1400051, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077140.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077140.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065754.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065754.1" } ] } }, { "isoform_ac": "A0AAA9S8F9-1", "url": "https://www.uniprot.org/uniprotkb/E1BBM3/entry#A0AAA9S8F9-1", "sequence": { "sequence": "VRRKKVEALKLVAKGIKNSDVSPPSGQQEMGGSPTKQPMRPVISVTSALKEVCMDQSLTDAQETSEEMQKSNSAVSSKREILRRLNQNLKVQENEKGRQSRRETGTVTVHEDAKELEKEKSVVSDRKKWETGGQLVLPVDELALDASFSVTEKHIVGEVIKLDPSGSPRKVWGKSPTDSVLRILGEAELQLQTELLENTSIRNEISPESENFKSLITEEEKVKCIPLEMNPPATLDSSVETNSPNISEASPQTALKAEGDLEEPDDLEAEVLQEPSGADRDGGLPQPVLDMWVTEREGAEEVELEDRITIQQNELSEDKAPSSVDHLSEVHVEPGVDDSPPSKRDIDKSMQPEPFFHKVVYSEHLKAVSQVQSVLCSPEESFPLRSHSDSPPRNKKQNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDGRQDNLEMEDEHVKEGPSDSEDIVFEEADTDLQELQASMEQLLQEQPGEDYSEEEESGLKTSDDAEQAANGTDAGEEDDNPSSESALNEEWHSDNSDGEITSECEYDSVFNHLEELRLHLEQEIGFEKFFEVYEKIKAVHEDEDENIEICSTIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE", "length": 625, "header": "tr|A0AAA9S8F9-1|E1BBM3_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=NEK1 PE=3 SV=1 CANONICAL=E1BBM3-1" }, "locus": { "chromosome": "8", "start_pos": 1445480, "end_pos": 1400051, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115360.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115360.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081542.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081542.1" } ] } }, { "isoform_ac": "A0AAA9T045-1", "url": "https://www.uniprot.org/uniprotkb/E1BBM3/entry#A0AAA9T045-1", "sequence": { "sequence": "MEKYIRVQKIGEGSFGKAILVRSTEDGRQYVIKEINISRMSNKEREESRREVAVLANMRHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTRDGTIQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIISGSFPPVSLHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGAQPLPAKRPASGQSLASIMSAQKITKPAAKYGIPLTNKKYIDKKLHERKPLQKYKQAHQTPVKKVNPGEERRKLFEEAPRKRRLELTEKEKKSKDQVSLLKAEQVKRQEKQRAPLLGSGGAMAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKGEIHGQRLPERQKGQPAMERAKQVEEFLQRRREAKQNKARAEGHMVYLARLRQIRLQNFNERQQIRAKLRGEKKETDSSEDQEGSEEADVRRKKVEALKAQASARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGIKNSDVSPPSGQQEMGGSPTKQPMRPVISVTSALKEVCMDQSLTDAQETSEEMQKSNSAVSSKREILRRLNQNLKVQENEKGRQSRRETGTVTVHEDAKELEKEKSVVSDRKKWETGGQLVLPVDELALDASFSVTEKHIVGEVIKLDPSGSPRKVWGKSPTDSVLRILGEAELQLQTELLENTSIRNEISPESENFKSLITEEEKVKCIPLEMNPPATLDSSVETNSPNISEASPQTALKAEGDLEEPDDLEAEVLQEPSGADRDGGLPQPVLDMWVTEREGAEEVELEDRITIQQNELSEDKAPSSVDHLSEVHVEPGVDDSPPSKRDIDKSMQPEPFFHKVVYSEHLKAVSQVQSVLCSPEESFPLRSHSDSPPRNKKQNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDGRQDNLEMEDEHVKEGPSDSEDIVFEEADTDLQELQASMEQLLQEQPGEDYSEEEESGLKTSDDAEQAANGTDAGEEDDNPSSESALNEEWHSDNSDGEITSECEYDSVFNHLEELRLHLEQEIGFEKFFEVYEKIKAVHEDEDENIEICSTIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE", "length": 1186, "header": "tr|A0AAA9T045-1|E1BBM3_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=NEK1 PE=3 SV=1 CANONICAL=E1BBM3-1" }, "locus": { "chromosome": "8", "start_pos": 1528177, "end_pos": 1400051, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132626.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132626.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091053.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091053.1" } ] } }, { "isoform_ac": "A0AAA9TA14-1", "url": "https://www.uniprot.org/uniprotkb/E1BBM3/entry#A0AAA9TA14-1", "sequence": { "sequence": "MEKYIRVQKIGEGSFGKAILVRSTEDGRQYVIKEINISRMSNKEREESRREVAVLANMRHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTRDGTIQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIISGSFPPVSLHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGAQPLPAKRPASGQSLASIMSAQKITKPAAKYGIPLTNKKYIDKKLHERKPLQKYKQAHQTPVKKVNPGEERRKLFEEAPRKRRLELTEKEKKSKDQLERINRAREQGWRNVLSAGGSGEMKAPLLGSGGAMAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKGEIHGQRLPERQKGQPAMERAKQVEEFLQRRREAKQNKARAEGHMVYLARLRQIRLQNFNERQQIRAKLRGEKKETDSSEDQEGSEEADVRRKKVEALKAQASARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGIKNSDVSPPSGQQEMGGSPTKQPMRPVISVTSALKEVCMDQSLTDAQETSEEMQKSNSAVSSKREILRRLNQNLKVQENEKGRQSRRETGTVTVHEDAKELEKEKSVVSDRKKWETGGQLVLPVDELALDASFSVTEKHIVGEVIKLDPSGSPRKVWGKSPTDSVLRILGEAELQLQTELLENTSIRNEISPESENFKSLITEEEKVKCIPLEMNPPATLDSSVETNSPNISEASPQTALKAEGDLEEPDDLEAEVLQEPSGADRDGGLPQPVLDMWVTEREGAEEVELEDRITIQQNELSEDKAPSSVDHLSEVHVEPGVDDSPPSKRDIDKSMQPEPFFHKVVYSEHLKAVSQVQSVLCSPEESFPLRSHSDSPPRNKKQNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDGRQDNLEMEDEHVKEGPSDSEDIVFEEADTDLQELQASMEQLLQEQPGEDYSEEEESGLKTSDDAEQAANGTDAGEEDDNPSSESALNEEWHSDNSDGEITSECEYDSVFNHLEELRLHLEQEIGFEKFFEVYEKIKAVHEDEDENIEICSTIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE", "length": 1195, "header": "tr|A0AAA9TA14-1|E1BBM3_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=NEK1 PE=3 SV=1 CANONICAL=E1BBM3-1" }, "locus": { "chromosome": "8", "start_pos": 1528177, "end_pos": 1400051, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115152.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115152.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094862.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094862.1" } ] } }, { "isoform_ac": "A0AAA9TIU9-1", "url": "https://www.uniprot.org/uniprotkb/E1BBM3/entry#A0AAA9TIU9-1", "sequence": { "sequence": "MEKYIRVQKIGEGSFGKAILVRSTEDGRQYVIKEINISRMSNKEREESRREVAVLANMRHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTRDGTIQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIISGSFPPVSLHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGAQPLPAKRPASGQSLASIMSAQKITKPAAKYGIPLTNKKYIDKKLHERKPLQKYKQAHQTPVKKVNPGEERRKLFEEAPRKRRLELTEKEKKSKDQVSLLKAEQVKRQEKQRLERINRAREQGWRNVLSAGGSGEMKAPLLGSGGAMAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKGEIHGQRLPERQKGQPAMERAKQVEEFLQRRREAKQNKARAEGHMGILHNLAALYGGRPSSSRGGKPRNKEEEVYLARLRQIRLQNFNERQQIRAKLRGEKKETDSSEDQEGSEEADVRRKKVEALKAQASARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGIKNSDVSPPSGQQEMGGSPTKQPMRPVISVTSALKEVCMDQSLTDAQETSEEMQKSNSAVSVEHIVGEVIKLDPSGSPRKVWGKSPTDSVLRILGEAELQLQTELLENTSIRNEISPESENFKSLITEEEKVKCIPLEMNPPATLDSSVETNSPNISEASPQTALKAEGDLEEPDDLEAEVLQEPSGADRDGGLPQPVLDMWVTEREGAEEVELEDRITIQQNELSEDKAPSSVDHLSEVHVEPGVDDSPPSKRDIDKSMQPEPFFHKVVYSEHLKAVSQVQSVLCSPEESFPLRSHSDSPPRNKKQNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDGRQDNLEMEDEHVKEGPSDSEDIVFEEADTDLQELQASMEQLLQEQPGEDYSEEEESGLKTSDDAEQAANGTDAGEEDDNPSSESALNEEWHSDNSDGEITSECEYDSVFNHLEELRLHLEQEIGFEKFFEVYEKIKAVHEDEDENIEICSTIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE", "length": 1164, "header": "tr|A0AAA9TIU9-1|E1BBM3_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=NEK1 PE=3 SV=1 CANONICAL=E1BBM3-1" }, "locus": { "chromosome": "8", "start_pos": 1528177, "end_pos": 1400051, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131495.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131495.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096827.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096827.1" } ] } }, { "isoform_ac": "A0AAA9TSB6-1", "url": "https://www.uniprot.org/uniprotkb/E1BBM3/entry#A0AAA9TSB6-1", "sequence": { "sequence": "MEKYIRVQKIGEGSFGKAILVRSTEDGRQYVIKEINISRMSNKEREESRREVAVLANMRHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTRDGTIQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIISGSFPPVSLHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGAQPLPAKRPASGQSLASIMSAQKITKPAAKYGIPLTNKKYIDKKLHERKPLQKYKQAHQTPVKKVNPGEERRKLFEEAPRKRRLELTEKEKKSKDQVSLLKAEQVKRQEKQRLERINRAREQGWRNVLSAGGSGEMKAPLLGSGGAMAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKGEIHGQRLPERQKGQPAMERAKQVEEFLQRRREAKQNKARAEGHMGILHNLAALYGGRPSSSRGGKPRNKEEEVYLARLRQIRLQNFNERQQIRAKLRGEKKETDSSEDQEGSEEADVRRKKVEALKAQASARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGIKNSDVSPPSGQQEMGGSPTKQPMRPVISVTSALKEVCMDQSLTDAQETSEEMQKSNSAVSSKREILRRLNQNLKVQENEKGRQSRRETGTVTVHEDAKELEKEKSVVSDRKKWETGGQLVLPVDELALDASFSVTEKHIVGEVIKLDPSGSPRKVWGKSPTDSVLRILGEAELQLQTELLENTSIRNEISPESENFKSLITEEEKVKCIPLEMNPPATLDSSVETNSPNISEASPQTALKAEGDLEEPDDLEAEVLQEPSGADRDGGLPQPVLDMWVTEREGAEEVELEDRITIQQNELSEDKAPSSVDHLSEVHVEPGVDDSPPSKRDIDKSMQPEPFFHKVVYSEHLKAVSQVQSVLCSPEESFPLRSHSDSPPRNKKQNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDGRQDNLEMEDEHVKEGPSDSEDIVFEEADTDLQELQASMEQLLQEQPGEDYSEEEESGLKTSDDAEQAANGTDAGEEDDNPSSESALNEEWHSDNSDGEITSECEYDSVFNHLEELRLHLEQEIGFEKFFEVYEKIKAVHEDEDENIEICSTIVQNILGNEHQHLYAKILHLVMADGAYQEGIGMKTDLFRSCGHC", "length": 1250, "header": "tr|A0AAA9TSB6-1|E1BBM3_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=NEK1 PE=3 SV=1 CANONICAL=E1BBM3-1" }, "locus": { "chromosome": "8", "start_pos": 1528177, "end_pos": 1385931, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117945.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117945.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101272.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101272.1" } ] } }, { "isoform_ac": "E1BBM3-1", "url": "https://www.uniprot.org/uniprotkb/E1BBM3/entry#E1BBM3-1", "sequence": { "sequence": "MEKYIRVQKIGEGSFGKAILVRSTEDGRQYVIKEINISRMSNKEREESRREVAVLANMRHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTRDGTIQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIISGSFPPVSLHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGAQPLPAKRPASGQSLASIMSAQKITKPAAKYGIPLTNKKYIDKKLHERKPLQKYKQAHQTPVKKVNPGEERRKLFEEAPRKRRLELTEKEKKSKDQVSLLKAEQVKRQEKQRLERINRAREQGWRNVLSAGGSGEMKAPLLGSGGAMAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKGEIHGQRLPERQKGQPAMERAKQVEEFLQRRREAKQNKARAEGHMGILHNLAALYGGRPSSSRGGKPRNKEEEVYLARLRQIRLQNFNERQQIRAKLRGEKKETDSSEDQEGSEEADVRRKKVEALKAQASARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGIKNSDVSPPSGQQEMGGSPTKQPMRPVISVTSALKEVCMDQSLTDAQETSEEMQKSNSAVSSKREILRRLNQNLKVQENEKGRQSRRETGTVTVHEDAKELEKEKSVVSDRKKWETGGQLVLPVDELALDASFSVTEKHIVGEVIKLDPSGSPRKVWGKSPTDSVLRILGEAELQLQTELLENTSIRNEISPESENFKSLITEEEKVKCIPLEMNPPATLDSSVETNSPNISEASPQTALKAEGDLEEPDDLEAEVLQEPSGADRDGGLPQPVLDMWVTEREGAEEVELEDRITIQQNELSEDKAPSSVDHLSEVHVEPGVDDSPPSKRDIDKSMQPEPFFHKVVYSEHLKAVSQVQSVLCSPEESFPLRSHSDSPPRNKKQNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDGRQDNLEMEDEHVKEGPSDSEDIVFEEADTDLQELQASMEQLLQEQPGEDYSEEEESGLKTSDDAEQAANGTDAGEEDDNPSSESALNEEWHSDNSDGEITSECEYDSVFNHLEELRLHLEQEIGFEKFFEVYEKIKAVHEDEDENIEICSTIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE", "length": 1239, "header": "tr|E1BBM3-1|E1BBM3_BOVIN Isoform 1 of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=NEK1 PE=3 SV=3 CANONICAL=E1BBM3-1" }, "locus": { "chromosome": "8", "start_pos": 1528177, "end_pos": 1400051, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018438.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018438.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018438.6", "url": "https://www.ensembl.org/id/ENSBTAP00000018438.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:534671", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534671", "resource": "KEGG Pathway" }, { "id": "R-BTA-9861718", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9861718", "resource": "Reactome", "description": "Regulation of pyruvate metabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AWJ2-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "NEK1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEKYVRVQKIGEGSFGKAILVKSIEDGRQYVIKEINISRMSNKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGILFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIISGSFPPVSLHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGAQPIPAKRPPSGQSLAFVISAPKITKPAAKYGVPLAYKKYGDKKLHEKKSLQKHKQAHQIPVKKVNPREERRKMFEEAARKGRLDFNDKEKKQKDQISLLKAEQMKRQEKERLEKINRAREQGWRNVLSASGAGGEVKAPVFGSGGAVAPALLSSRGQYEHYHAIFDQMQQQRAEDNEAKWKAEVNGQRLPERQKGQLAVERAKQVEEFLQRRREARQNKARAEGHVGILQNLAALYGGRPSSSRGGKPRNKEEEVYLARLRQIRLQNFNERQQIRAKLRGEKEADSSEGQEGTEEADVRRKKVEALKAQVSARASVLKEQLERKRREAYEREKKAWEEHLVARGLKSSDVSPPSGQQGAGGSPPRHPVRPVISVTSALKEVGVDRSLTDAQETSEEMQKTNNAISSKREILRRLNQNLKAQEDEKGKQSPSETGAINILEDAKEQEKEKPVSSDRKKWEAGGQLVIPVDELTLDTSFSATEKHTVGEVIKLDSSGSPRKVWGKSPTDSVLKVLGEAELQLQTELLENTTNSSALGVIYGLATWEEISPEREEILKEKIKCISLEMKPSATVDSSVETNSPDFSEAETALKPEGNVDEPDDLEMEVLQEPSRADRDSHPPCSAVTVWMSDGKDAGEVELEDRVPTQQNEGSEDGAMGSVGHLGEVHVEPGADSSQPSVCDADKSVQPEPFFHKVAHSQQLKVISQVHSALCSPEESFPLRSLSDSPPKTKKQSSLLIGLSTGLFDANNPKLLRTCSLPDLSKLFRTLMDVPTVGDVRQDSLGMDEMEDEHIKEGPSDSEDIVFEEADTDLQELQASMEQLLREQPGEDSSDAEQAANGPDAGDEDDNPSSGSALNEEWHSDNSDGEITSECEYDSVFNHLEELRLHLEQEIGFEKFFEVYEKIKAVHEDEDENIEICSTVAEDLLGSEHQHLYAKILHLVMADGAYQEDNDE", "length": 1236 }, "evidence": [ { "id": "E1BBM3", "url": "https://omabrowser.org/oma/group/E1BBM3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Y074-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "NEK1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDKYIKVQKIGEGSFGKAFLVKDKENSQQYVIKEINISKMSNKEREESRREVAVLANMKHPNIVLYRESFEENGCLYIVMDYCEGGDLFKKINAQKGVLFSEDQILDWFVQICLALKHIHDRKILHRDIKSQNIFLTKDGTIQLGDFGIARVLNSTVELARTCIGTPYYLSPEICQNRPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIISGSFPPVSVHYSYDLRNLLSQLFKRNPRDRPSVNSILEKNFIAKRVEKFLTPQLIAEEFSHKVFHKFGPHAGPAKRPAQGHISASIAPVQKITKPAAKYGVPLAMKKCYDAPKKLHEKKSLIKLRQAFPTPKKKIIPGEERRKMFEEPSKKKRLELPEKEKRQRDQISLLKAEEMRRLEKERMERINRAREQGWRNVLGSGGSGDVKAPYYGGGGGVGPFPASFRGQYEHYHAIFDQMQKETFKVTKERQAKWRAEVQGQEAVERGIPPGVRPGVPKGPAGHHHLPDADAIRKKVKRLKEVSKQASANRQKGWLPAERAKQVEEFWQRKREAMQNKARAEGHMGTLQNVADIYGGRPMSARGRKSRNKEEEEYLARLRQIRLQNFNERQQIKAKLRGEKNEAPSSDGQESSEEAEMKRKKIEAQKAQANARAAVLKEQLERKRKEAYEREKRAWEEHLIAKGVKNPNVPFHVGAAGHTPVHGIQEPGVSPPKQQLPVKPISMTSALKEVGVDGNVTAAQEVKEEIKKPDLTMQNKRQILKRLNQNLKAQEDEKGRKDDKNISESDGSEDGKEEQEDNHPLLGDRKRWASRASDLVVPLAQLSMEDSLSGTDRQTMGEVIRLDIGEPRRKVWGKSPTDSVLKILGEAELQLPTELLEEIDVINEPDDLEAVMLKETEEDKKHQSKEFPIAVNEVWVKEKQDEAQQDARNEAAFEKEVVLDEVQSQNEAPEETCSSDSLQPEPLFQRVIQPPAVPTASPVLSSQSSQEEPFVPRSRSISPAKNKGKSSLFFGLSTGLFDANNPKMLRTCSLPDLYKLYRTLIDVPSIADVQHQHSLEIDDTEDEQAKEGPSDSEDIMFGDADTDLQELRASMEQLLREQPSEELSEEEESTLKANVIKCMTNGTELDEADENNPSSESALNEEWQSDNSDGDIASECEECDSVFSHLEELRYNLEQEIGFEKLIEVYNKIKAIHEDEDENIDICSSIVQTILGNEHKHLYAKVLHLVMADGAYQEDNDE", "length": 1233 }, "evidence": [ { "id": "E1BBM3", "url": "https://omabrowser.org/oma/group/E1BBM3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZB99-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "Nek1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEKYVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKEREESRREVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQKGTLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSLHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTVSKFGPQPIPGKRPASGQGVSSFVPAQKITKPSAKYGVPITYKKYGDKKLLEKKPPPKHKQAHQIPVKKMNSGEERKKMSEEAAKKRRLEFIEKEKKQKDQIRFLKAEQLKRQEKQRLERINRAREQGWRNVLRAGGSGEVKASFFGSGGAVSPSPCSPRGQYEHYHAIFDQMQQLRAEDNEARWKGRIYGRWLPERQKGHLGVERAKQVEEFLQRKQEAMQNKARAEGHVVYLARLRQIRLQNFNERQQIKAKLRGENKEAGGTKGQDATEEADMRLKKMESLKAQANARAAVLKEQLERKRKEAYEREKKVWEEHLVVRVKSSDVPPSMEHHEAGGSPSQQQMKPVISVTSALKEVGLDGSLTESQETSEEMEKSNNAISSKREILRRLNENLKAQEDEKEKHHHADSCETVGHRDEREYEKENAISSDRKKWEMGGQLVIPLDEVTLDASFSASESVYEYVNVMTWLISHINSDPGHPKEPTCGWLEREHTVGEVIKLDSSGSPRKVWGKSPTDSVLKILGEAELQLQTELLENTPFKSEVCVEEENYKPLLTGEENLQCISKEVNPSATVDTETNSPKFAKVSPAMSEGNVEEPDDLETEVLQEPSAIPSDGSLPPVVNEVWTRAKATGLEDSIAVQQNDVCEERIPGTVDQSCKDHIEPAGNDSPQSGCDEEKSVQPELFFQKVVHSKDLNLVQSAHRSPEEAIPIRSHSDSPPKAKSKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVHQDSLEIEELEDEHIKEGPSDCEDIVFEETDTDLQELQASMEQLLREQPGDEYSEEEESVLKSSNVERAARGTDVPDEEDNPSSESALNEEWHSDNSDAETTSECEYDSVFNHLEELRLHLEQEMGFEKFFEVYEKVKAIHEDEDENIEISSTIVENILGTEHQHLYAKILHLVMADGAYQEDNDE", "length": 1233 }, "evidence": [ { "id": "E1BBM3", "url": "https://omabrowser.org/oma/group/E1BBM3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H3C3-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "Nek1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDKYVRLQKIGEGSFGKAVLVKSIEDSMHYVIKEINISRMSGRERQESRSEVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQKGTLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSSVDLARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSLHYSYELRSLLSQLFKRNPRDRPSVNSILDKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGPQPIPGKRAASGQSSITLVPAQKITKPAAKYGVPLTHKKHGDKKSLEKKPPPKHKHTHQIIVKKMNSGEERRKMFEEATKKRRLEFIEKEKKQKEQISFLKAEQVKRQEKQRLERINRAREQGWRNVLRAGGSGEVKTPFFGSGGAVSPSPCSSRRQYEHYHAIFDQMQRLRAEDNETSWKQEIYGRRLPERQKGYLAVERAKQVEEFLQRKREAMQNKARAEGHVGILQNLASLYGGRPSSSRGGKPRNNEEEVYLARLRQIRLQNFNERQQIKARLRGENKEANGTKGPEATEEADLRLKKMESLKAQTNARVAVLKEQLERKRKEAYEREKRVWEEQLVERIKSSDVSPPLEHQERAGSPSKQQMRPVISVTSAMKEVGLEGSLTGTQESAEEMQKSNNAISSKREILRRLNENLKAQEDEKEKQHHSDSCEIVGHKDAKEYEKANAVSSDRKKWEVGGQLVIPLDELTLDMSFSATETHTVGEVIKLDSNGSPRKVWGKSPTDSVLKILGEADLQLQTELLENTTSKSEIYPEEENYKPLLIGEEKPECISEEINPSATVDSIETKSPQFCEVPPPISEENVEEPDDLETEVLQEPSSTDTDGSLPCVVNDVWIGEEEAKETELEDKVAMQQSEVYEARIPENVNQSYEDYIESAVGDSQQSGFDVGKSVQPEPFFQKVLHSEHLNLVQSTHCPPEESVLLRTRSDSPPKTKTKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVHQDSLEIDELEDEHIKEGPSDFEDTVFEETDTDLQELQASMEQLLREQPGDEYSEEEELVLKSSDVEQTARGTDVADEDDNPSSESALNEEWHSDNSDVEITSECKCDSVFNHLEELRLHLEQEMGFEKFFEVYEKVKAIHEDEDENIEICSTIVENILGNEHQHLYAKILHLVMADGAYQEDNDE", "length": 1232 }, "evidence": [ { "id": "E1BBM3", "url": "https://omabrowser.org/oma/group/E1BBM3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P51954-1", "protein_name": "Serine/threonine-protein kinase Nek1", "gene_name": "Nek1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEKYVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKERQESRREVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQKGALFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTLSKFGPQPLPGKRPASGQGVSSFVPAQKITKPAAKYGVPLTYKKYGDKKLLEKKPPPKHKQAHQIPVKKMNSGEERKKMSEEAAKKRRLEFIEKEKKQKDQIRFLKAEQMKRQEKQRLERINRAREQGWRNVLRAGGSGEVKASFFGIGGAVSPSPCSPRGQYEHYHAIFDQMQRLRAEDNEARWKGGIYGRWLPERQKGHLAVERANQVEEFLQRKREAMQNKARAEGHVVYLARLRQIRLQNFNERQQIKAKLRGENKEADGTKGQEATEETDMRLKKMESLKAQTNARAAVLKEQLERKRKEAYEREKKVWEEHLVARVKSSDVPLPLELLETGGSPSKQQVKPVISVTSALKEVGLDGSLTDTQEEEMEKSNSAISSKREILRRLNENLKAQEDEKEKQHHSGSCETVGHKDEREYETENAISSDRKKWEMGGQLVIPLDAVTLDTSFSATEKHTVGEVIKLDSNGSPRKVWGKNPTDSVLKILGEAELQLQTELLENTSFKSEVYAEEENYKPLLTEEENLQCISKEINPSATVDSTETKSPKFTEVSPQMSEGNVEEPDDLETEVLQEPSSTHTDGSLPPVLNDVWTREKEAAKETELEDKVAVQQSEVCEDRIPGNVDQSCKDQRDPAVDDSPQSGCDVEKSVQPESIFQKVVHSKDLNLVQAVHCSPEEPIPIRSHSDSPPKTKSKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVHQDSLEIDELEDEPIKEGPSDSEDTVFEETDTDLQELQASMEQLLREQPGDEYSEEEESVLKSSDVEQTARGTDAPDEEDNPSSESALNEEWHSDNSDAETTSECEYDSVFNHLEELRLHLEQEMGFEKFFEVYEKVKAIHEDEDENIEICSTIVENILGNEHQHLYAKILHLVMADGAYQEDNDE", "length": 1203 }, "evidence": [ { "id": "E1BBM3", "url": "https://omabrowser.org/oma/group/E1BBM3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96PY6-1", "protein_name": "Serine/threonine-protein kinase Nek1", "gene_name": "NEK1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSISVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISEEAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGEVKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPERGILPGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQRKREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADMRRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHETGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENLKAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFSTTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEGEKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLETEILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSDIHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSHLPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEIDEIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEPTANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFEKFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE", "length": 1258 }, "evidence": [ { "id": "E1BBM3", "url": "https://omabrowser.org/oma/group/E1BBM3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "E1BBM3", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1BBM3", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BBM3", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ], "pmid": "" }, { "name": "protein kinase activity", "id": "GO:0004672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "evidence": [ { "database": "UniProtKB", "id": "E1BBM3", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BBM3", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BBM3", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ], "pmid": "" }, { "name": "centriolar satellite", "id": "GO:0034451", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034451", "evidence": [ { "database": "UniProtKB", "id": "E1BBM3", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ], "pmid": "" }, { "name": "pericentriolar material", "id": "GO:0000242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000242", "evidence": [ { "database": "UniProtKB", "id": "E1BBM3", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "E1BBM3", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1124, "end_pos": 1126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 182, "end_pos": 184, "annotation": "n_glycosylation_sequon" }, { "start_pos": 36, "end_pos": 38, "annotation": "n_glycosylation_sequon" }, { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" }, { "start_pos": 812, "end_pos": 814, "annotation": "n_glycosylation_sequon" }, { "start_pos": 859, "end_pos": 861, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", 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"L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] }, { "id": "R-BTA-9861642", "name": "NEK1 phosphorylates ME1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-BTA-400119" ], "output_participant_list": [], "enzyme_list": [ "E1BBM3-1" ], "evidence": [ { "id": "R-BTA-9861642", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9861642" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-400119", "participant_name": "ME1 [cytosol]", "crossref": [ { "id": "F1N3V0", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000005681", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000007465", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000007465", "database": "ENSEMBL", "url": "" }, { "id": "31339", "database": "VGNC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": 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O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", 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O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", 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"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBM3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1239, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBM3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBM3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 258, "start_aa": "Tyr", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.1", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1" }, { "id": "2.7.11.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1124, "end_pos": 1126 }, { "start_pos": 154, "end_pos": 156 }, { "start_pos": 182, "end_pos": 184 }, { "start_pos": 36, "end_pos": 38 }, { "start_pos": 73, "end_pos": 75 }, { "start_pos": 812, "end_pos": 814 }, { "start_pos": 859, "end_pos": 861 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCR7-1", "uniprot_ac": "E1BCR7", "uniprot_id": "E1BCR7_BOVIN", "mass": { "chemical_mass": 62151.0, "monoisotopic_mass": 62151.0 }, "refseq": { "ac": "XP_024850651", "name": "GPI mannosyltransferase 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850651" }, "gene_names": [ { "name": "PIGZ", "type": "recommended", "evidence": [ { "id": "E1BCR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCR7" } ] }, { "name": "PIGZ", "type": "synonym", "evidence": [ { "id": "XP_024850651", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850651" } ] } ], "protein_names": [ { "name": "Mannosyltransferase", "type": "recommended", "evidence": [ { "id": "E1BCR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCR7/entry#names_and_taxonomy" } ] }, { "name": "2.4.1.-", "type": "synonym", "evidence": [ { "id": "E1BCR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCR7/entry#names_and_taxonomy" } ] }, { "name": "GPI mannosyltransferase 4", "type": "synonym", "evidence": [ { "id": "XP_024850651", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850651" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCR7", "url": "https://www.uniprot.org/uniprotkb/E1BCR7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PIGZ", "url": "https://www.uniprot.org/uniprotkb/E1BCR7", "locus": { "chromosome": "1", "start_pos": 71414946, "end_pos": 71433480, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011659", "url": "https://www.ensembl.org/id/ENSBTAG00000011659" } ] } } ], "crossref": [ { "id": "E1BCR7", "url": "https://alphafold.ebi.ac.uk/entry/E1BCR7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011659", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011659", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "104968672", "url": "https://www.ncbi.nlm.nih.gov/gene/104968672", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:104968672", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104968672", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HGIHPRY", "url": "https://omabrowser.org/oma/group/HGIHPRY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCR7", "url": "https://www.orthodb.org/?gene=E1BCR7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22760", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22760", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22760:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22760:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03901", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03901", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-162710", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-162710", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024850651", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850651", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1ND19", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ND19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ND19-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ND19-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCB9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCB9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCR7", "url": "https://www.uniprot.org/uniprotkb/E1BCR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCR7-1", "url": "https://www.uniprot.org/uniprotkb/E1BCR7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEMEARVLWGSLGLLRLVWCLLPQTGYVHPDEFFQSPEVMAGDILGIEAARPWEFHPSSPCRTAVFPLLTSGSAFWLLRLWEEWGPWPGVVSGYLLLVGPRLLLTALSFALDLAVYHLAPGWGAERWNALLLLSGSYVTLVFYTRTFSNAIEGLLFAWLLVLVSPRAARSRTPRKPAPGPRWHGWLLGGLVVAGFFNRPTFLAFALVPLFLWGTCGATDPSFKSLTQQALTLLPGASLTAVAFVAVDSWYFSGPSRPSTLVLTPANFLRYNLDPVNLARHGTHARLTHLAVNGFLLFGMLHAHSLQAAWQQLRAGLQAFAQMGFPRTLEAWSPRPSPRSLLLLFYFVPLALLSAFSHQEARFLIPLLVPLVLLCSLQTQPAPCRGTLALFNVLGALFFGCLHQGGLVPGLGHLERVVHAPEPLRVPTHFTLVFTHTYMPPRHLLHLPGLGLPVDVVDMGGAEDWVLCQALNNFTRHAACQAAGGPWLCRLFVVTPGTTRPAVRKCRFPLKSETLIFPHLTLEDPPALSSLLSSAWRDHLSLHILELGEKPDNMTQKPLPKTQP", "length": 563, "header": "tr|E1BCR7-1|E1BCR7_BOVIN Isoform 1 of Mannosyltransferase OS=Bos taurus OX=9913 GN=PIGZ PE=3 SV=3 CANONICAL=E1BCR7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1ND19-1", "url": "https://www.uniprot.org/uniprotkb/E1BCR7/entry#A0A3Q1ND19-1", "sequence": { "sequence": "DSGRRCVEVCYPAATQDKPGDILGIEAARPWEFHPSSPCRTAVFPLLTSGSAFWLLRLWEEWGPWPGVVSGYLLLVGPRLLLTALSFALDLAVYHLAPGWGAERWNALLLLSGSYVTLVFYTRTFSNAIEGLLFAWLLVLVSPRAARSRTPRKPAPGPRWHGWLLGGLVVAGFFNRPTFLAFALVPLFLWGTCGATDPSFKSLTQQALTLLPGASLTAVAFVAVDSWYFSGPSRPSTLVLTPANFLRYNLDPVNLARHGTHARLTHLAVNGFLLFGMLHAHSLQAAWQQLRAGLQAFAQMGFPRTLEAWSPRPSPRSLLLLFYFVPLALLSAFSHQEARFLIPLLVPLVLLCSLQTQPAPCRGTLALFNVLGALFFGCLHQGGLVPGLGHLERVVHAPEPLRVPTHFTLVFTHTYMPPRHLLHLPGLGLPVDVVDMGGAEDWVLCQALNNFTRHAACQAAGGPWLCRLFVVTPGTTRPAVRKCRFPLKSETLIFPHLTLEDPPALSSLLSSAWRDHLSLHILELGEKPDNMTQKPLPKTQP", "length": 541, "header": "tr|A0A3Q1ND19-1|E1BCR7_BOVIN Computationally mapped isoform of Mannosyltransferase OS=Bos taurus OX=9913 GN=PIGZ PE=3 SV=2 CANONICAL=E1BCR7-1" }, "locus": { "chromosome": "1", "start_pos": 71428327, "end_pos": 71415331, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070456.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070456.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069348.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069348.2" } ] } }, { "isoform_ac": "A0AAA9TCB9-1", "url": "https://www.uniprot.org/uniprotkb/E1BCR7/entry#A0AAA9TCB9-1", "sequence": { "sequence": "MTEDEMVGWHHRFIGRDILGIEAARPWEFHPSSPCRTAVFPLLTSGSAFWLLRLWEEWGPWPGVVSGYLLLVGPRLLLTALSFALDLAVYHLAPGWGAERWNALLLLSGSYVTLVFYTRTFSNAIEGLLFAWLLVLVSPRAARSRTPRKPAPGPRWHGWLLGGLVVAGFFNRPTFLAFALVPLFLWGTCGATDPSFKSLTQQALTLLPGASLTAVAFVAVDSWYFSGPSRPSTLVLTPANFLRYNLDPVNLARHGTHARLTHLAVNGFLLFGMLHAHSLQAAWQQLRAGLQAFAQMGFPRTLEAWSPRPSPRSLLLLFYFVPLALLSAFSHQEARFLIPLLVPLVLLCSLQTQPAPCRGTLALFNVLGALFFGCLHQGGLVPGLGHLERVVHAPEPLRVPTHFTLVFTHTYMPPRHLLHLPGLGLPVDVVDMGGAEDWVLCQALNNFTRHAACQAAGGPWLCRLFVVTPGTTRPAVRKCRFPLKSETLIFPHLTLEDPPALSSLLSSAWRDHLSLHILELGEKPDNMTQKPLPKTQP", "length": 537, "header": "tr|A0AAA9TCB9-1|E1BCR7_BOVIN Computationally mapped isoform of Mannosyltransferase OS=Bos taurus OX=9913 GN=PIGZ PE=3 SV=1 CANONICAL=E1BCR7-1" }, "locus": { "chromosome": "1", "start_pos": 71420861, "end_pos": 71415331, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098273.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098273.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095701.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095701.1" } ] } }, { "isoform_ac": "E1BCR7-1", "url": "https://www.uniprot.org/uniprotkb/E1BCR7/entry#E1BCR7-1", "sequence": { "sequence": "MEMEARVLWGSLGLLRLVWCLLPQTGYVHPDEFFQSPEVMAGDILGIEAARPWEFHPSSPCRTAVFPLLTSGSAFWLLRLWEEWGPWPGVVSGYLLLVGPRLLLTALSFALDLAVYHLAPGWGAERWNALLLLSGSYVTLVFYTRTFSNAIEGLLFAWLLVLVSPRAARSRTPRKPAPGPRWHGWLLGGLVVAGFFNRPTFLAFALVPLFLWGTCGATDPSFKSLTQQALTLLPGASLTAVAFVAVDSWYFSGPSRPSTLVLTPANFLRYNLDPVNLARHGTHARLTHLAVNGFLLFGMLHAHSLQAAWQQLRAGLQAFAQMGFPRTLEAWSPRPSPRSLLLLFYFVPLALLSAFSHQEARFLIPLLVPLVLLCSLQTQPAPCRGTLALFNVLGALFFGCLHQGGLVPGLGHLERVVHAPEPLRVPTHFTLVFTHTYMPPRHLLHLPGLGLPVDVVDMGGAEDWVLCQALNNFTRHAACQAAGGPWLCRLFVVTPGTTRPAVRKCRFPLKSETLIFPHLTLEDPPALSSLLSSAWRDHLSLHILELGEKPDNMTQKPLPKTQP", "length": 563, "header": "tr|E1BCR7-1|E1BCR7_BOVIN Isoform 1 of Mannosyltransferase OS=Bos taurus OX=9913 GN=PIGZ PE=3 SV=3 CANONICAL=E1BCR7-1" }, "locus": { "chromosome": "1", "start_pos": 71419349, "end_pos": 71415331, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015483.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015483.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015483.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015483.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:104968672", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104968672", "resource": "KEGG Pathway" }, { "id": "R-BTA-162710", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-162710", "resource": "Reactome", "description": "Synthesis of glycosylphosphatidylinositol (GPI)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2M9U5-1", "protein_name": "Mannosyltransferase", "gene_name": "Pigz", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKMAARVIWGSLSLLRVLWCLLPQTGYIHPDEFFQSPEVMAEDILGVQASRPWEFYPSNSCRTVVFPLLTSGSTFWLLRLWEELGPWPGLVSGYKLLVGPRLLLTTLSFALDWAMYYLAPLWGADRWNAMCLLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSPYVAWSPTSKKPTPGPWWHSCLLGAIVAAGFFNRPTFLAFALAPLSLWGIHRALEPGIKALTQEALVLLPGAVLAAVLFITMDSWYFSSLSRSSGLVLTPVNFLYYNLDPQNLARHGTHARLTHLAVNGFLLFGVLHAQALQAAWQQLHSCLHAVAQTGLLRARGPQGLLPSSKSYLLLLYFTPLVLLSAFSHQEARFLIPLIVPLILLCSPQTQPIPWRGTLVLFNALGALIFGCLHQGGLVPGLKYLEHVVHAPVLPGRATHYTLLFTHTYMPPQHLLHLSGLGSPVEVVDMAGAEDRVLCQALNNFSRQPGCQQAGGPQLCRLFVVTPGTNRHALEKCSFSLKNETLLFPHLTLEDPPALSSLLSGAWRTHLSLHVIELEEKPVMTKQPWPKIQP", "length": 562 }, "evidence": [ { "id": "E1BCR7", "url": "https://omabrowser.org/oma/group/E1BCR7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LAS0-1", "protein_name": "Mannosyltransferase", "gene_name": "PIGZ", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQICGTRIASVAAEVILGSGPVSWQQFDMKTAARMLWGSLSLLRLVWCLLPQTGYVHPDEFFQSPEVMAEDILGIEAARPWEFQPSSPCRTVVFPLLTSGSAFWLLRLWEEWGPWPGPVSGYVLLVGPRLLLTTLSFALDVAVYHLAPRWGAERWSALVLLSGSYVTLVFYTRTFSNAIEGLLFAWLLVLVSPRVAGSPTPEKPAPGPWWHSWLLGGIVAAGFFNRPTFLAFALVPLFLWGTYGPTSPSFRSLTKEALVLLPGAALTAAVFVAVDSWYFSSPSRPRTLILTPANFLRYNLDPVNLARHGTHMQLTHLAVNGFLLFGVLHAHALQAAWRQLRACLQAFARVGFLRALDAWRLQSRSHLLLIYFTPLALLSAFSHQEARFLIPLLVPLVLLCSPQTQPAPCKGTLALFNALGALFFGCLHQGGLVPGLGHLERVVHAPVLPHVSTRYTLLFTHTYMPPRHLLHLPGLGSPVEVVDMAGSEDWLLCQALNNFTRQPACQVAGGPWLCRLFVVTPGTTRPAVKKCSFPLKNEALIFPHLTLEDPPALSSLLSGAWREHLSLHILELGEQPDNMTADPLAGTQP", "length": 589 }, "evidence": [ { "id": "E1BCR7", "url": "https://omabrowser.org/oma/group/E1BCR7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q1ZXB4-1", "protein_name": "Mannosyltransferase", "gene_name": "smp3", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLKKVILSILYNLKNVIFNRNNNYNNNNKNKIPLPNSYCISILIRFIVGVLAIGYIHPDEYFQSPEITSSFMFNFKTFTPWEFNDSNPCRSVVIPFNLSHRKSLSILSSCWLIIIFHSRTFSNTIESLLVATLLTIILLYKKSISKGENTFFKDLLIGIIVSCGIFARFTFIFFATPLGIYLLYLLFQSSSSSSSATKSSINNNSNNGCKKFTKSKLSCIISIILIIFGFLIASSFFIIIDSIYFNYLDHLKLISDFNLITSNINTSDLFLSSNSTIDIINQISNIPKHPLISDLNSTHIISFLKNNLTYTPINSFLYNLDVDNLSDHGIHNRLTHLFVNLPMMVGPLVLLLFIEIISILKNGFNVNKQTNNVNNNNNNTNNNNNNNNNTNNNNNDNHNHSGIDNGSIKRNHHSSSSLSQSSTSPSNRKEVFPISIRILLVSIILFGLFFLSLAPHQEPRFLLPLFFPLALLSYRYFYFNKKSSKLLLILWILFNMILTIFFGFVHQGGVTPSLVYIGSKIVKPQQQQQYLLLGEIENNLNITNSNINNNKINNENLQKSNNKLNNITIMFYHTYMPPRYLLGIERNNEKINLLDLGGKDINSLKNLVDEIKGSKIFILSPTKDILYQQYKDKTCQLTESFWPHLTTEDPPQSIDELRLFMFECNDL", "length": 667 }, "evidence": [ { "id": "E1BCR7", "url": "https://omabrowser.org/oma/group/E1BCR7/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q86VD9-1", "protein_name": "GPI alpha-1,2-mannosyltransferase 4", "gene_name": "PIGZ", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQICGSSVASVAAGTSFQVLGPVCWQQLDLKMAVRVLWGGLSLLRVLWCLLPQTGYVHPDEFFQSPEVMAEDILGVQAARPWEFYPSSSCRSVLFPLLISGSTFWLLRLWEELGPWPGLVSGYALLVGPRLLLTALSFALDGAVYHLAPPMGADRWNALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVTWGPTRKEPAPGPRWRSWLLGGIVAAGFFNRPTFLAFAVVPLYLWGTRGATNPGLKSLTREALVLLPGAALTAAVFVATDSWYFSSPATSRNLVLTPVNFLHYNLNPQNLARHGTHARLTHLAVNGFLLFGVLHAQALQAAWQRLQVGLQASAQMGLLRALGARSLLSSPRSYLLLLYFMPLALLSAFSHQEARFLIPLLVPLVLLCSPQTQPVPWKGTVVLFNALGALLFGCLHQGGLVPGLEYLEQVVHAPVLPSTPTHYTLLFTHTYMPPRHLLHLPGLGAPVEVVDMGGTEDWALCQTLKSFTRQPACQVAGGPWLCRLFVVTPGTTRRAVEKCSFPFKNETLLFPHLTLEDPPALSSLLSGAWRDHLSLHIVELGEET", "length": 579 }, "evidence": [ { "id": "E1BCR7", "url": "https://omabrowser.org/oma/group/E1BCR7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BTP0-1", "protein_name": "GPI alpha-1,2-mannosyltransferase 4", "gene_name": "Pigz", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMVAAQVIWGSFSLLRVLWCLLPQTGYIHPDEFFQSPEVMAEDILGVQATRPWEFYPSSSCRTVVFPLLTSGSTFWLLRLWEELGLWPGLVSGYMLLVGPRFLLTALSFALDWAVYDLAPLWGADRWNALCLLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSPGVVRSPTSKKPTPGPRWHRYLLGVILAAGFFNRPTFLAFALAPLSLWGIHRASELGGIRALIQEALVLLPGAALAAVLCVATDSWYFSSLSRSTGVFLTPANFLYYNLDPQNLARHGTHARLTHLAVNGFLLFGVLHAQALQAAWQQLHACLRASPQTGLSRVRGARGLLSSSKSYLLLFYFTPLLLLSAFSHQEARFLIPLLVPLVLLCSPQTQPIPWKGTLVLFNILGALIFGCLHQGGLVPGLKYLEQIVHTPDLSGTTTHYTLLFTHTYMPPQHLLHLSGLGSPVEVVDMGGAEDRVLCQALNNFSRQPACQLAGEPWPCRLFVVTPGTNRHALEKCRFPLKNETLLFPHLTLEDPPALSSLLSGAWRKHLSLHVIELETPVVTKQPKAQP", "length": 560 }, "evidence": [ { "id": "E1BCR7", "url": "https://omabrowser.org/oma/group/E1BCR7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "E1BCR7", "url": "https://www.uniprot.org/uniprotkb/E1BCR7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "glycosyltransferase activity", "id": "GO:0016757", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016757", "evidence": [ { "database": "UniProtKB", "id": "E1BCR7", "url": "https://www.uniprot.org/uniprotkb/E1BCR7" } ], "pmid": "" }, { "name": "alpha-1,2-mannosyltransferase activity", "id": "GO:0000026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000026", "evidence": [ { "database": "UniProtKB", "id": "E1BCR7", "url": "https://www.uniprot.org/uniprotkb/E1BCR7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "GPI anchor biosynthetic process", "id": "GO:0006506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006506", "evidence": [ { "database": "UniProtKB", "id": "E1BCR7", "url": "https://www.uniprot.org/uniprotkb/E1BCR7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 472, "end_pos": 474, "annotation": "n_glycosylation_sequon" }, { "start_pos": 552, "end_pos": 554, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-162797", "name": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-8855664" ], "enzyme_list": [ "E1BCR7-1" ], "evidence": [ { "id": "R-BTA-162797", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-162797" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-8855664", "participant_name": "mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI [lumenal side of endoplasmic reticulum membrane]", "crossref": [ { "id": "63563", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "E1BCR7", "gene_name": "PIGZ", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "E1BCR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCR7" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCR7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 563, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCR7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCR7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 472, "end_pos": 474 }, { "start_pos": 552, "end_pos": 554 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BBW0-1", "uniprot_ac": "E1BBW0", "uniprot_id": "E1BBW0_BOVIN", "mass": { "chemical_mass": 81602.0, "monoisotopic_mass": 81602.0 }, "refseq": { "ac": "XP_005222468", "name": "leucine-rich repeat flightless-interacting protein 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222468" }, "gene_names": [ { "name": "LRRFIP2", "type": "recommended", "evidence": [ { "id": "E1BBW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBW0" } ] }, { "name": "LRRFIP2", "type": "synonym", "evidence": [ { "id": "XP_005222468", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222468" } ] } ], "protein_names": [ { "name": "Leucine-rich repeat flightless-interacting protein 2", "type": "recommended", "evidence": [ { "id": "E1BBW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBW0/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat flightless-interacting protein 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005222468", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222468" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBW0", "url": "https://www.uniprot.org/uniprotkb/E1BBW0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRFIP2", "url": "https://www.uniprot.org/uniprotkb/E1BBW0", "locus": { "chromosome": "22", "start_pos": 10455986, "end_pos": 10347060, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016760", "url": "https://www.ensembl.org/id/ENSBTAG00000016760" } ] } } ], "crossref": [ { "id": "E1BBW0", "url": "https://alphafold.ebi.ac.uk/entry/E1BBW0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016760", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016760", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510368", "url": "https://www.ncbi.nlm.nih.gov/gene/510368", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019139", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019139", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M2C7", "url": "https://www.orthodb.org/?gene=A0A3Q1M2C7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M3S5", "url": "https://www.orthodb.org/?gene=A0A3Q1M3S5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MDJ8", "url": "https://www.orthodb.org/?gene=A0A3Q1MDJ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MF05", "url": "https://www.orthodb.org/?gene=A0A3Q1MF05", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1ND84", "url": "https://www.orthodb.org/?gene=A0A3Q1ND84", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BBW0", "url": "https://www.orthodb.org/?gene=E1BBW0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MP70", "url": "https://www.orthodb.org/?gene=F1MP70", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19212", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19212", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19212:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19212:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09738", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09738", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005222468", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222468", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2C7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2C7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2C7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2C7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3S5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3S5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3S5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3S5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDJ8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MF05", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MF05-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF05-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ND84", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ND84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ND84-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ND84-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEV4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUR8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBW0", "url": "https://www.uniprot.org/uniprotkb/E1BBW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBW0-1", "url": "https://www.uniprot.org/uniprotkb/E1BBW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MP70", "url": "https://www.uniprot.org/uniprotkb/F1MP70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MP70-1", "url": "https://www.uniprot.org/uniprotkb/F1MP70-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTPGSGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEHSHHSFDRKWGQIQKWLEESERARSSHRSSHRRPSLGVEDALSIRSLGSHRYDALKDRSSRLSSLNHSYSHSYGMKKRSSGSHKDPLSGLYFDQRNYSSLRHSKPTSAYYSRQSSSLYSDPLATSKSYRASSTVNSGLLRSASLVSLYNGGLYNPYGSRTPSEYSFHSSRASSSRSSPVFLDDDTASIASSGCASRGRRDSVVSAADYFSRSNRRGSVVSDVDDVSIPDLTSLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEEKQRMQQKIDTMTKEVFELQETLLWKDKSIRALEKLKEHAGCLRSERDALREELAKLKAAVEVGEKHGLVIIPDGTPNGDVHQEPAVGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSGRDGTAGDLAELQNGSDLQLIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYRTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ", "length": 721, "header": "tr|E1BBW0-1|E1BBW0_BOVIN Isoform 1 of Leucine-rich repeat flightless-interacting protein 2 OS=Bos taurus OX=9913 GN=LRRFIP2 PE=3 SV=3 CANONICAL=E1BBW0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M2C7-1", "url": "https://www.uniprot.org/uniprotkb/E1BBW0/entry#A0A3Q1M2C7-1", "sequence": { "sequence": "MGTPGSGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEEESERARSSHRSSHRRPSLGVEDALSIRSLGSHRNHSYSHSYGMKKRSSGSHKDPLVSLYNGGLYNPYGSRTLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEEKQRMQQKIDTMTKEVFELQETLLWKDKSIRKHGLVIIPDGTPNGDVHQEPAVGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSGRDGTAGDLAELQNGSDLQLIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYRTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ", "length": 503, "header": "tr|A0A3Q1M2C7-1|E1BBW0_BOVIN Computationally mapped isoform of Leucine-rich repeat flightless-interacting protein 2 OS=Bos taurus OX=9913 GN=LRRFIP2 PE=3 SV=2 CANONICAL=E1BBW0-1" }, "locus": { "chromosome": "22", "start_pos": 10455837, "end_pos": 10371858, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083202.3", "url": "https://www.ensembl.org/id/ENSBTAT00000083202.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063928.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063928.2" } ] } }, { "isoform_ac": "A0A3Q1M3S5-1", "url": "https://www.uniprot.org/uniprotkb/E1BBW0/entry#A0A3Q1M3S5-1", "sequence": { "sequence": "MGTPGSGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEGVEDALSIRSLGSHRLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEALEKLKEHAGCLRSERDALREELAKLKAAVEVGEKHGLVIIPDGTPNGDVHQEPAVGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSGRDGTAGDLAELQNGSDLQLIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYRTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ", "length": 449, "header": "tr|A0A3Q1M3S5-1|E1BBW0_BOVIN Computationally mapped isoform of Leucine-rich repeat flightless-interacting protein 2 OS=Bos taurus OX=9913 GN=LRRFIP2 PE=3 SV=3 CANONICAL=E1BBW0-1" }, "locus": { "chromosome": "22", "start_pos": 10455837, "end_pos": 10371858, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084010.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084010.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064423.3", "url": "https://www.ensembl.org/id/ENSBTAP00000064423.3" } ] } }, { "isoform_ac": "A0A3Q1MDJ8-1", "url": "https://www.uniprot.org/uniprotkb/E1BBW0/entry#A0A3Q1MDJ8-1", "sequence": { "sequence": "MGTPGSGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEALEKLKEHAGCLRSERDALREELAKLKAAVEVGEKHGLVIIPDGTPNGDVHQEPAVGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSGRDGTAGDLAELQNGSDLQLIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYRTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ", "length": 434, "header": "tr|A0A3Q1MDJ8-1|E1BBW0_BOVIN Computationally mapped isoform of Leucine-rich repeat flightless-interacting protein 2 OS=Bos taurus OX=9913 GN=LRRFIP2 PE=3 SV=3 CANONICAL=E1BBW0-1" }, "locus": { "chromosome": "22", "start_pos": 10455837, "end_pos": 10371858, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072976.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072976.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069008.3", "url": "https://www.ensembl.org/id/ENSBTAP00000069008.3" } ] } }, { "isoform_ac": "A0A3Q1MF05-1", "url": "https://www.uniprot.org/uniprotkb/E1BBW0/entry#A0A3Q1MF05-1", "sequence": { "sequence": "MGTPGSGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEEESERARSSHRSSHRRPSLGVEDALSIRSLGSHRFLDDDTASIASSGCASRGRRDSVLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEKHGLVIIPDGTPNGDVHQEPAVGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSGRDGTAGDLAELQNGSDLQLIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYRTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ", "length": 481, "header": "tr|A0A3Q1MF05-1|E1BBW0_BOVIN Computationally mapped isoform of Leucine-rich repeat flightless-interacting protein 2 OS=Bos taurus OX=9913 GN=LRRFIP2 PE=3 SV=2 CANONICAL=E1BBW0-1" }, "locus": { "chromosome": "22", "start_pos": 10455837, "end_pos": 10371858, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069995.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069995.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069091.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069091.2" } ] } }, { "isoform_ac": "A0A3Q1ND84-1", "url": "https://www.uniprot.org/uniprotkb/E1BBW0/entry#A0A3Q1ND84-1", "sequence": { "sequence": "MGTPGSGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEGVEDALSIRSLGSHRVSLYNGGLYNPYGSRTPSEYSFHSSRASSSRSSPVLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEALEKLKEHAGCLRSERDALREELAKLKAAVEVGEKHGLVIIPDGTPNGDVHQEPAVGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSGRDGTAGDLAELQNGSDLQLIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYRTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ", "length": 484, "header": "tr|A0A3Q1ND84-1|E1BBW0_BOVIN Computationally mapped isoform of Leucine-rich repeat flightless-interacting protein 2 OS=Bos taurus OX=9913 GN=LRRFIP2 PE=3 SV=3 CANONICAL=E1BBW0-1" }, "locus": { "chromosome": "22", "start_pos": 10455837, "end_pos": 10371858, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071605.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071605.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069438.3", "url": "https://www.ensembl.org/id/ENSBTAP00000069438.3" } ] } }, { "isoform_ac": "A0AAA9SEQ6-1", "url": "https://www.uniprot.org/uniprotkb/E1BBW0/entry#A0AAA9SEQ6-1", "sequence": { "sequence": "MGTPGSGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEEESERARSSHRSSHRRPSLGVEDALSIRSLGSHRVSLYNGGLYNPYGSRTPSEYSFHSSRASSSRSSPVFLDDDTASIASSGCASRGRRDSVLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEKHGLVIIPDGTPNGDVHQEPAVGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSGRDGTAGDLAELQNGSDLQLIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYRTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ", "length": 492, "header": "tr|A0AAA9SEQ6-1|E1BBW0_BOVIN Computationally mapped isoform of Leucine-rich repeat flightless-interacting protein 2 OS=Bos taurus OX=9913 GN=LRRFIP2 PE=3 SV=1 CANONICAL=E1BBW0-1" }, "locus": { "chromosome": "22", "start_pos": 10455837, "end_pos": 10371858, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121843.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121843.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084619.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084619.1" } ] } }, { "isoform_ac": "A0AAA9SEV4-1", "url": "https://www.uniprot.org/uniprotkb/E1BBW0/entry#A0AAA9SEV4-1", "sequence": { "sequence": "MGTPGSGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEVSLYNGGLYNPYGSRTPSEYSFHSSRASSSRSSPVLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEALEKLKEHAGCLRSERDALREELAKLKAAVEVGEKHGLVIIPDGTPNGDVHQEPAVGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSGRDGTAGDLAELQNGSDLQLIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYRTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ", "length": 469, "header": "tr|A0AAA9SEV4-1|E1BBW0_BOVIN Computationally mapped isoform of Leucine-rich repeat flightless-interacting protein 2 OS=Bos taurus OX=9913 GN=LRRFIP2 PE=3 SV=1 CANONICAL=E1BBW0-1" }, "locus": { "chromosome": "22", "start_pos": 10455837, "end_pos": 10371858, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119959.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119959.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084681.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084681.1" } ] } }, { "isoform_ac": "A0AAA9TUR8-1", "url": "https://www.uniprot.org/uniprotkb/E1BBW0/entry#A0AAA9TUR8-1", "sequence": { "sequence": "MGTPGSGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEVTGENNPPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEKHGLVIIPDGTPNGDVHQEPAVGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSGRDGTAGDLAELQNGSDLQLIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYRTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ", "length": 392, "header": "tr|A0AAA9TUR8-1|E1BBW0_BOVIN Computationally mapped isoform of Leucine-rich repeat flightless-interacting protein 2 OS=Bos taurus OX=9913 GN=LRRFIP2 PE=3 SV=2 CANONICAL=E1BBW0-1" }, "locus": { "chromosome": "22", "start_pos": 10455837, "end_pos": 10371858, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088485.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088485.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101099.2", "url": "https://www.ensembl.org/id/ENSBTAP00000101099.2" } ] } }, { "isoform_ac": "E1BBW0-1", "url": "https://www.uniprot.org/uniprotkb/E1BBW0/entry#E1BBW0-1", "sequence": { "sequence": "MGTPGSGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEHSHHSFDRKWGQIQKWLEESERARSSHRSSHRRPSLGVEDALSIRSLGSHRYDALKDRSSRLSSLNHSYSHSYGMKKRSSGSHKDPLSGLYFDQRNYSSLRHSKPTSAYYSRQSSSLYSDPLATSKSYRASSTVNSGLLRSASLVSLYNGGLYNPYGSRTPSEYSFHSSRASSSRSSPVFLDDDTASIASSGCASRGRRDSVVSAADYFSRSNRRGSVVSDVDDVSIPDLTSLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEEKQRMQQKIDTMTKEVFELQETLLWKDKSIRALEKLKEHAGCLRSERDALREELAKLKAAVEVGEKHGLVIIPDGTPNGDVHQEPAVGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSGRDGTAGDLAELQNGSDLQLIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYRTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ", "length": 721, "header": "tr|E1BBW0-1|E1BBW0_BOVIN Isoform 1 of Leucine-rich repeat flightless-interacting protein 2 OS=Bos taurus OX=9913 GN=LRRFIP2 PE=3 SV=3 CANONICAL=E1BBW0-1" }, "locus": { "chromosome": "22", "start_pos": 10455837, "end_pos": 10371858, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056583.5", "url": "https://www.ensembl.org/id/ENSBTAT00000056583.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052423.4", "url": "https://www.ensembl.org/id/ENSBTAP00000052423.4" } ] } }, { "isoform_ac": "F1MP70-1", "url": "https://www.uniprot.org/uniprotkb/E1BBW0/entry#F1MP70-1", "sequence": { "sequence": "MGTPGSGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEFLDDDTASIASSGCASRGRRDSVLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEKHGLVIIPDGTPNGDVHQEPAVGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSGRDGTAGDLAELQNGSDLQLIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYRTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ", "length": 447, "header": "tr|F1MP70-1|E1BBW0_BOVIN Computationally mapped isoform of Leucine-rich repeat flightless-interacting protein 2 OS=Bos taurus OX=9913 GN=LRRFIP2 PE=3 SV=2 CANONICAL=E1BBW0-1" }, "locus": { "chromosome": "22", "start_pos": 10455837, "end_pos": 10371858, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022298.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022298.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022298.4", "url": "https://www.ensembl.org/id/ENSBTAP00000022298.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "E1BBW0", "url": "https://www.uniprot.org/uniprotkb/E1BBW0" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "E1BBW0", "url": "https://www.uniprot.org/uniprotkb/E1BBW0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "LRR domain binding", "id": "GO:0030275", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030275", "evidence": [ { "database": "UniProtKB", "id": "E1BBW0", "url": "https://www.uniprot.org/uniprotkb/E1BBW0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 303, "end_pos": 305, "annotation": "n_glycosylation_sequon" }, { "start_pos": 322, "end_pos": 324, "annotation": "n_glycosylation_sequon" }, { "start_pos": 613, "end_pos": 615, "annotation": "n_glycosylation_sequon" }, { "start_pos": 713, "end_pos": 715, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBW0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 721, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBW0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBW0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 125, "end_pos": 127 }, { "start_pos": 155, "end_pos": 157 }, { "start_pos": 303, "end_pos": 305 }, { "start_pos": 322, "end_pos": 324 }, { "start_pos": 613, "end_pos": 615 }, { "start_pos": 713, "end_pos": 715 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { 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} ] } } ], "crossref": [ { "id": "E1BA23", "url": "https://alphafold.ebi.ac.uk/entry/E1BA23", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015821", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015821", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000051340", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051340", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01319", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01319", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR006329", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006329", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11359", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11359", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11359:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11359:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF19326", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19326", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "14777", "url": "https://www.rhea-db.org/rhea/14777", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NK86", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NK86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NK86-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NK86-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNY0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNY0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA23", "url": "https://www.uniprot.org/uniprotkb/E1BA23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA23-1", "url": "https://www.uniprot.org/uniprotkb/E1BA23-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTPAPGSAEMPRQFPKLNISEVDEQVRLLAEKVFAKVLREEDSKDALSLFTVPEDCPIGQKEAKERELQKELAEQKSLETAKRKKSFKMIRSQSLSLQMPTQQDWKGPPTASPAISPATPVLPGATPLPAPAPYAVPEFQRVTISGDYCAGITVEDYEQAAKSLAKALMIREKYARLAYHRFPRTTAQYLGHRRLDTTPLEEGLPDFHPPLPEEDPYCLENAPPNLGYLVRMQGGILYVYDNKKMLEHQEPHSLPYPDLETYTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFDSLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARMVKEVAWELEESKYQYSEPRLSIYGRSPEEWPNLARWFIQHKVYSPNMRWIIQVPRIYDIFRLKKLLPSFGKMLENIFLPLFEATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDKSPSPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKSEEITALTN", "length": 776, "header": "tr|E1BA23-1|E1BA23_BOVIN Isoform 1 of AMP deaminase OS=Bos taurus OX=9913 GN=AMPD3 PE=3 SV=4 CANONICAL=E1BA23-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NK86-1", "url": "https://www.uniprot.org/uniprotkb/E1BA23/entry#A0A3Q1NK86-1", "sequence": { "sequence": "MPRQFPKLNISEVDEQVRLLAEKVFAKVLREEDSKDALSLFTVPEDCPIGQKEAKERELQKELAEQKSLETAKRKKSFKMIRSQSLSLQMPTQQDWKGPPTASPAISPATPVLPGATPLPAPAPYAVPEFQRVTISGDYCAGITVEDYEQAAKSLAKALMIREKYARLAYHRFPRTTAQYLGHRRLDTTPLEEGLPDFHPPLPEEDPYCLENAPPNLGYLVRMQGGILYVYDNKKMLEHQEPHSLPYPDLETYTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFDSLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARMVKEVAWELEESKYQYSEPRLSIYGRSPEEWPNLARWFIQHKVYSPNMRWIIQVPRIYDIFRLKKLLPSFGKMLENIFLPLFEATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDKSPSPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKSEEITALTN", "length": 766, "header": "tr|A0A3Q1NK86-1|E1BA23_BOVIN Computationally mapped isoform of AMP deaminase OS=Bos taurus OX=9913 GN=AMPD3 PE=3 SV=2 CANONICAL=E1BA23-1" }, "locus": { "chromosome": "15", "start_pos": 42220569, "end_pos": 42183573, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068513.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068513.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072695.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072695.2" } ] } }, { "isoform_ac": "A0AAA9TNY0-1", "url": "https://www.uniprot.org/uniprotkb/E1BA23/entry#A0AAA9TNY0-1", "sequence": { "sequence": "MALSPELAEMPRQFPKLNISEVDEQVRLLAEKVFAKVLREEDSKDALSLFTVPEDCPIGQKEAKERELQKELAEQKSLETAKRKKSFKMIRSQSLSLQMPTQQDWKGPPTASPAISPATPVLPGATPLPAPAPYAVPEFQRVTISGDYCAGITVEDYEQAAKSLAKALMIREKYARLAYHRFPRTTAQYLGHRRLDTTPLEEGLPDFHPPLPEEDPYCLENAPPNLGYLVRMQGGILYVYDNKKMLEHQEPHSLPYPDLETYTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFDSLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARMVKEVAWELEESKYQYSEPRLSIYGRSPEEWPNLARWFIQHKVYSPNMRWIIQVPRIYDIFRLKKLLPSFGKMLENIFLPLFEATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDKSPSPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKSEEITALTN", "length": 775, "header": "tr|A0AAA9TNY0-1|E1BA23_BOVIN Computationally mapped isoform of AMP deaminase OS=Bos taurus OX=9913 GN=AMPD3 PE=3 SV=1 CANONICAL=E1BA23-1" }, "locus": { "chromosome": "15", "start_pos": 42232108, "end_pos": 42183573, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126194.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126194.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098935.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098935.1" } ] } }, { "isoform_ac": "E1BA23-1", "url": "https://www.uniprot.org/uniprotkb/E1BA23/entry#E1BA23-1", "sequence": { "sequence": "MGTPAPGSAEMPRQFPKLNISEVDEQVRLLAEKVFAKVLREEDSKDALSLFTVPEDCPIGQKEAKERELQKELAEQKSLETAKRKKSFKMIRSQSLSLQMPTQQDWKGPPTASPAISPATPVLPGATPLPAPAPYAVPEFQRVTISGDYCAGITVEDYEQAAKSLAKALMIREKYARLAYHRFPRTTAQYLGHRRLDTTPLEEGLPDFHPPLPEEDPYCLENAPPNLGYLVRMQGGILYVYDNKKMLEHQEPHSLPYPDLETYTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFDSLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARMVKEVAWELEESKYQYSEPRLSIYGRSPEEWPNLARWFIQHKVYSPNMRWIIQVPRIYDIFRLKKLLPSFGKMLENIFLPLFEATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDKSPSPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKSEEITALTN", "length": 776, "header": "tr|E1BA23-1|E1BA23_BOVIN Isoform 1 of AMP deaminase OS=Bos taurus OX=9913 GN=AMPD3 PE=3 SV=4 CANONICAL=E1BA23-1" }, "locus": { "chromosome": "15", "start_pos": 42224136, "end_pos": 42183573, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021018.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021018.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021018.7", "url": "https://www.ensembl.org/id/ENSBTAP00000021018.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BA23", "url": "https://www.uniprot.org/uniprotkb/E1BA23" } ], "pmid": "" }, { "name": "AMP deaminase activity", "id": "GO:0003876", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003876", "evidence": [ { "database": "UniProtKB", "id": "E1BA23", "url": "https://www.uniprot.org/uniprotkb/E1BA23" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "IMP salvage", "id": "GO:0032264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032264", "evidence": [ { "database": "UniProtKB", "id": "E1BA23", "url": "https://www.uniprot.org/uniprotkb/E1BA23" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" }, { "start_pos": 614, "end_pos": 616, "annotation": "n_glycosylation_sequon" }, { "start_pos": 645, "end_pos": 647, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "14777", "name": "", "equation": "AMP + H2O + H(+) = IMP + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BA23-1", "A0AAA9SYM4-1", "A0A3Q1M723-1" ], "evidence": [ { "id": "14777", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14777" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M723", "gene_name": "AMPD2", "activity": [ { "ec_number": "3.5.4.6", "activity": "AMP + H2O + H(+) = IMP + NH4(+).", "evidence": [ { "id": "A0A3Q1M723", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M723" } ] }, { "ec_number": "3.5.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1M723", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M723" } ] } ] }, { "uniprot_ac": "A0AAA9SYM4", "gene_name": "AMPD1", "activity": [ { "ec_number": "3.5.4.6", "activity": "AMP + H2O + H(+) = IMP + NH4(+).", "evidence": [ { "id": "A0AAA9SYM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYM4" } ] }, { "ec_number": "3.5.4.6", "activity": "", "evidence": [ { "id": "A0AAA9SYM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYM4" } ] } ] }, { "uniprot_ac": "E1BA23", "gene_name": "AMPD3", "activity": [ { "ec_number": "3.5.4.6", "activity": "AMP + H2O + H(+) = IMP + NH4(+).", "evidence": [ { "id": "E1BA23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA23" } ] }, { "ec_number": "3.5.4.6", "activity": "", "evidence": [ { "id": "E1BA23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA23" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BA23-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 776, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BA23-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BA23" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.5.4.6", "ec_name": "AMP + H2O + H(+) = IMP + NH4(+).", "evidence": [ { "id": "3.5.4.6", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6" }, { "id": "3.5.4.6", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.5.4.6" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 19, "end_pos": 21 }, { "start_pos": 614, "end_pos": 616 }, { "start_pos": 645, "end_pos": 647 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BBN5-1", "uniprot_ac": "E1BBN5", "uniprot_id": "E1BBN5_BOVIN", "mass": { "chemical_mass": 103786.0, "monoisotopic_mass": 103786.0 }, "refseq": { "ac": "XP_024832566", "name": "E3 ubiquitin-protein ligase MIB2 isoform X5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832566" }, "gene_names": [ { "name": "MIB2", "type": "recommended", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] }, { "name": "MIB2", "type": "synonym", "evidence": [ { "id": "XP_024832566", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832566" } ] } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase MIB2", "type": "recommended", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.27", "type": "synonym", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5/entry#names_and_taxonomy" } ] }, { "name": "E3 ubiquitin-protein ligase MIB2 isoform X5", "type": "synonym", "evidence": [ { "id": "XP_024832566", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832566" } ] }, { "name": "Mind bomb homolog 2", "type": "synonym", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5/entry#names_and_taxonomy" } ] }, { "name": "RING-type E3 ubiquitin transferase MIB2", "type": "synonym", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.", "evidence": [ { "database": "UniProtKB", "id": "E1BBN5", "url": "https://www.uniprot.org/uniprotkb/E1BBN5#function" }, { "database": "UniProtKB", "id": "ARBA00056224", "url": "https://www.uniprot.org/uniprotkb/ARBA00056224#function" }, { "database": "UniProtKB", "id": "A0A3Q1MFB2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFB2#function" }, { "database": "UniProtKB", "id": "A0AAA9RZ36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ36#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBN5", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MIB2", "url": "https://www.uniprot.org/uniprotkb/E1BBN5", "locus": { "chromosome": "16", "start_pos": 51007096, "end_pos": 51019798, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010720", "url": "https://www.ensembl.org/id/ENSBTAG00000010720" } ] } } ], "crossref": [ { "id": "E1BBN5", "url": "https://alphafold.ebi.ac.uk/entry/E1BBN5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010720", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010720", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02339", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02339", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16726", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16726", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538270", "url": "https://www.ncbi.nlm.nih.gov/gene/538270", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010606", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010606", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040847", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040847", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HGACEHC", "url": "https://omabrowser.org/oma/group/HGACEHC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MFB2", "url": "https://www.orthodb.org/?gene=A0A3Q1MFB2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NLQ6", "url": "https://www.orthodb.org/?gene=A0A3Q1NLQ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BBN5", "url": "https://www.orthodb.org/?gene=E1BBN5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24202", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24202", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24202:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24202:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00569", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00569", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06701", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06701", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13857", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13857", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13920", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13920", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18346", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18346", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5357786", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5357786", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5357905", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5357905", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9931295", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931295", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024832566", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832566", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFB2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFB2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFB2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NLQ6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NLQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NLQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NLQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZ36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZ36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ36-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P0P6", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0P6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P0P6-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0P6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBN5", "url": "https://www.uniprot.org/uniprotkb/E1BBN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBN5-1", "url": "https://www.uniprot.org/uniprotkb/E1BBN5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDHGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLRGMRWKCRICFDYDLCTQCYMHNKHDLAHAFERYETAHSRPVMLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYRDHLPRLGKPAELQRRVSADGQPFQRGDKVKCLLDADVLREMQEGHGGWNPRMAKFIGQTGTVHRITDRGDVRVQFSHKTRWTFHPGALTKQNSCLVGEVVRVIDDLDTVKRLQAGHGEWTDDMAPALGRIGRVLKVFGDGNVGVLVSGKLWTFSPSCLVAYRPEEDANLDVAGRARENKSSLSVVLDKLRAQKSDLEHPGKLVVEVALGNVARALDLLRRHPEQVDTKNQGRTALQMAAYLGQVELVRLLLQAQAGVDLPDDEGNTALHYAALGNQPEAARVLLSSGCGANALNSTRSSALHVAVQRGFLEVVKVLCERGCDVNLPDAHADTPLHCAISAGTGASGIVEVLTEVPGIDVTATNSQGFTLLHHASLKGHTLAVRRILARARQLVDAKKEDGFTALHLAAFNNHGEVAQVLIQEGHCDVNARNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLAADGSAGDPGPLQLLSRLQASGLPSSAELTAGAAMAYYLALEGADLSYANHRGRSPLDLAAEGRLLKALQGCAQRFRERQAGGSGSGGSAQGPRLVLSAPNTVTNLHVAAPTGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVISKKLRPDGTEVVSAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGAALSACPICRQPIRDRIQIFV", "length": 959, "header": "tr|E1BBN5-1|E1BBN5_BOVIN Isoform 1 of E3 ubiquitin-protein ligase MIB2 OS=Bos taurus OX=9913 GN=MIB2 PE=4 SV=3 CANONICAL=E1BBN5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MFB2-1", "url": "https://www.uniprot.org/uniprotkb/E1BBN5/entry#A0A3Q1MFB2-1", "sequence": { "sequence": "MDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDHGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLRGMRWKCRICFDYDLCTQCYMHNKHDLAHAFERYETAHSRPVMLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYRDHLPRLGKPAELQRRVSADGQPFQRGDKVKCLLDADVLREMQEGHGGWNPRMAKQNSCLVGEVVRVIDDLDTVKRLQAGHGEWTDDMAPALGRIGRVLKVFGDGNVGVLVSGKLWTFSPSCLVAYRPEEDANLDVAGRARENKSSLSVVLDKLRAQKSDLEHPGKLVVEVALGNVARALDLLRRHPEQVDTKNQGRTALQMAAYLGQVELVRLLLQAQAGVDLPDDEGNTALHYAALGNQPEAARVLLSSGCGANALNSTRSSALHVAVQRGFLEVVKVLCERGCDVNLPDAHADTPLHCAISAGTGASGIVEVLTEVPGIDVTATNSQGFTLLHHASLKGHTLAVRRILARARQLVDAKKEDGFTALHLAAFNNHGEVAQVLIQEGHCDVNARNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLAADGSAGDPGPLQLLSRLQASGLPSSAELTAGAAMAYYLALEGADLSYANHRGRSPLDLAAEGRLLKALQGCAQRFRERQAGGSGSGGSAQGPRLVLSAPNTVTNLHVAAPTGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVISKKLRPDGTEVVSAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGAALSACPICRQPIRDRIQIFV", "length": 923, "header": "tr|A0A3Q1MFB2-1|E1BBN5_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase MIB2 OS=Bos taurus OX=9913 GN=MIB2 PE=4 SV=2 CANONICAL=E1BBN5-1" }, "locus": { "chromosome": "16", "start_pos": 51014518, "end_pos": 51007889, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079241.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079241.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069215.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069215.2" } ] } }, { "isoform_ac": "A0A3Q1NLQ6-1", "url": "https://www.uniprot.org/uniprotkb/E1BBN5/entry#A0A3Q1NLQ6-1", "sequence": { "sequence": "MDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDHGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLRGMRWKCRICFDYDLCTQCYMHNKHDLAHAFERYETAHSRPVMLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGKPAELQRRVSADGQPFQRGDKVKCLLDADVLREMQEGHGGWNPRMAKFIGQTGTVHRITDRGDVRVQFSHKTRWTFHPGALTKQNSCLVGEVVRVIDDLDTVKRLQAGHGEWTDDMAPALGRIGRVLKVFGDGNVGVLVSGKLWTFSPSCLVAYRPEEDANLDVAGRARENKSSLSVVLDKLRAQKSDLEHPGKLVVEVALGNVARALDLLRRHPEQVDTKNQGRTALQMAAYLGQVELVRLLLQAQAGVDLPDDEGNTALHYAALGNQPEAARVLLSSGCGANALNSTRSSALHVAVQRGFLEVVKVLCERGCDVNLPDAHADTPLHCAISAGTGASGIVEVLTEVPGIDVTATNSQGFTLLHHASLKGHTLAVRRILARARQLVDAKKEDGFTALHLAAFNNHGEVAQVLIQEGHCDVNARNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLAADGSAGDPGPLQLLSRLQASGLPSSAELTAGAAMAYYLALEGADLSYANHRGRSPLDLAAEGRLLKALQGCAQRFRVRAQDEEMHQVPGGHQQEAAPRRHGGGQRSPRARPTAAVGGGAAEPLQADGGAHHLSDLHRQPHPPRVPVRPRRVRALWRGAQRLPDLPPAHPRPHPDLRVAGAPRLVPGPCPAAALTSPFSVFYKKIAGLCAWLPVWGGAVRVPHR", "length": 876, "header": "tr|A0A3Q1NLQ6-1|E1BBN5_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase MIB2 OS=Bos taurus OX=9913 GN=MIB2 PE=4 SV=2 CANONICAL=E1BBN5-1" }, "locus": { "chromosome": "16", "start_pos": 51014518, "end_pos": 51007749, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067570.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067570.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073371.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073371.2" } ] } }, { "isoform_ac": "A0AAA9RZ36-1", "url": "https://www.uniprot.org/uniprotkb/E1BBN5/entry#A0AAA9RZ36-1", "sequence": { "sequence": "MDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDHGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLRGMRWKCRICFDYDLCTQCYMHNKHDLAHAFERYETAHSRPVMLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGKPAELQRRVSADGQPFQRGDKVKCLLDADVLREMQEGHGGWNPRMAKFIGQTGTVHRITDRGDVRVQFSHKTRWTFHPGALTKQNSCLVGEVVRVIDDLDTVKRLQAGHGEWTDDMAPALGRIGRVLKVFGDGNVGVLVSGKLWTFSPSCLVAYRPEEDANLDVAGRARENKSSLSVVLDKLRAQKSDLEHPGKLVVEVALGNVARALDLLRRHPEQVDTKNQGRTALQMAAYLGQVELVRLLLQAQAGVDLPDDEGNTALHYAALGNQPEAARVLLSSGCGANALNSTRSSALHVAVQRGFLEVVKVLCERGCDVNLPDAHADTPLHCAISAGTGASGIVEVLTEVPGIDVTATNSQGFTLLHHASLKGHTLAVRRILARARQLVDAKKEDGFTALHLAAFNNHGEVAQVLIQEGHCDVNARNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLAADGSAGDPGPLQLLSRLQASGLPSSAELTAGAAMAYYLALEGADLSYANHRGRSPLDLAAEGRLLKALQGCAQRFRERQAGGSGSGGSAQGPRLVLSAPNTVTNLHVAAPTGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVISKKLRPDGTEVVSAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGAALSACPICRQPIRDRIQIFV", "length": 894, "header": "tr|A0AAA9RZ36-1|E1BBN5_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase MIB2 OS=Bos taurus OX=9913 GN=MIB2 PE=4 SV=1 CANONICAL=E1BBN5-1" }, "locus": { "chromosome": "16", "start_pos": 51014518, "end_pos": 51007889, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105090.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105090.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075033.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075033.1" } ] } }, { "isoform_ac": "A0ABI0P0P6-1", "url": "https://www.uniprot.org/uniprotkb/E1BBN5/entry#A0ABI0P0P6-1", "sequence": { "sequence": "MDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDHGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLRGMRWKCRICFDYDLCTQCYMHNKHDLAHAFERYETAHSRPVMLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYRDHLPRLGKPAELQRRVSADGQPFQRGDKVKCLLDADVLREMQEGHGGWNPRMAKFIGQTGTVHRITDRGDVRVQFSHKTRWTFHPGALTKQNSCLVGEVVRVIDDLDTVKRLQAGHGEWTDDMAPALGRIGRVLKVFGDGNVGVLVSGKLWTFSPSCLVAYRPEEDANLDVAGRARENKSSLSVVLDKLRAQKSDLEHPGKLVVEVALGNVARALDLLRRHPEQVDTKNQGRTALQMAAYLGQVELVRLLLQAQAGVDLPDDEGNTALHYAALGNQPEAARVLLSSGCGANALNSTRSSALHVAVQRGFLEVVKVLCERGCDVNLPDAHADTPLHCAISAGTGASGIVEVLTEVPGIDVTATNSQGFTLLHHASLKGHTLAVRRILARARQLVDAKKEDGFTALHLAAFNNHGEVAQVLIQEGHCDVNARNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLAADGSAGDPGPLQLLSRLQASGLPSSAELTAGAAMAYYLALEGADLSYANHRGRSPLDLAAEGRLLKALQGCAQRFRERQAGGSGSGGSAQGPRLVLSAPNTVTNLHVAAPTGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVISKKLRPDLSPEPPPL", "length": 889, "header": "tr|A0ABI0P0P6-1|A0ABI0P0P6_BOVIN Computationally mapped isoform of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=MIB2 PE=4 SV=1 CANONICAL=E1BBN5-1" }, "locus": { "chromosome": "16", "start_pos": 51014518, "end_pos": 51008144, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151911.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151911.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104868.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104868.1" } ] } }, { "isoform_ac": "E1BBN5-1", "url": "https://www.uniprot.org/uniprotkb/E1BBN5/entry#E1BBN5-1", "sequence": { "sequence": "MDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDHGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLRGMRWKCRICFDYDLCTQCYMHNKHDLAHAFERYETAHSRPVMLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYRDHLPRLGKPAELQRRVSADGQPFQRGDKVKCLLDADVLREMQEGHGGWNPRMAKFIGQTGTVHRITDRGDVRVQFSHKTRWTFHPGALTKQNSCLVGEVVRVIDDLDTVKRLQAGHGEWTDDMAPALGRIGRVLKVFGDGNVGVLVSGKLWTFSPSCLVAYRPEEDANLDVAGRARENKSSLSVVLDKLRAQKSDLEHPGKLVVEVALGNVARALDLLRRHPEQVDTKNQGRTALQMAAYLGQVELVRLLLQAQAGVDLPDDEGNTALHYAALGNQPEAARVLLSSGCGANALNSTRSSALHVAVQRGFLEVVKVLCERGCDVNLPDAHADTPLHCAISAGTGASGIVEVLTEVPGIDVTATNSQGFTLLHHASLKGHTLAVRRILARARQLVDAKKEDGFTALHLAAFNNHGEVAQVLIQEGHCDVNARNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLAADGSAGDPGPLQLLSRLQASGLPSSAELTAGAAMAYYLALEGADLSYANHRGRSPLDLAAEGRLLKALQGCAQRFRERQAGGSGSGGSAQGPRLVLSAPNTVTNLHVAAPTGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVISKKLRPDGTEVVSAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGAALSACPICRQPIRDRIQIFV", "length": 959, "header": "tr|E1BBN5-1|E1BBN5_BOVIN Isoform 1 of E3 ubiquitin-protein ligase MIB2 OS=Bos taurus OX=9913 GN=MIB2 PE=4 SV=3 CANONICAL=E1BBN5-1" }, "locus": { "chromosome": "16", "start_pos": 51014518, "end_pos": 51007889, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014195.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014195.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014195.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014195.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 47, "start_aa": "Thr", "end_pos": 47, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr47", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-5357786", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5357786", "resource": "Reactome", "description": "TNFR1-induced proapoptotic signaling" }, { "id": "R-BTA-5357905", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5357905", "resource": "Reactome", "description": "Regulation of TNFR1 signaling" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" }, { "id": "R-BTA-9931295", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931295", "resource": "Reactome", "description": "PD-L1(CD274) glycosylation and translocation to plasma membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B5E3-1", "protein_name": "E3 ubiquitin-protein ligase MIB2", "gene_name": "MIB2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDHGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCRKHGLRGMRWKCRVCFDYDLCTQCYMHNKHDLAHAFERYETAHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYREHLPRLGKPAELQRRVSADGQPFQPGDKVKCLLDTDILREMQEGHGGWNPRMAEFIGQPGTVHRITDRGDVRVQFSHKIRWTFHPGALTKHNSFWVGDVVRVIDDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVSGHLWTFSPSCLVAYRPEEDANLDVAERARENKSSLSIILDKLRAQKCDLEHPGRLVVEVALGNMARALDLLRRHPEQVDTKNQGRTALQVAAYLGQVELVRLLLQARAGVDLVDDEGNTALHYAALGNQPEAARVLLSSGCAANALNSARSSALHVAVQRGFLEVVRVLCERGCDVNLPDAHADTPLHCAISAGTGATGIVEVLTEVPGIDVTATNSQGFTLLHHASLKGHTLAVRRILARARQLVDAQKEDGFTALHLAALNNHWEVAQVLIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDSGCSVNAEDEEGDTALHVALQRHQLLPMAADGAGGDPGPLQLLSRLQASGLPGSAELTAGAAVACFLALEGADLSYANHRGRSPLDLATEGRLLKALQCCAQRFRERQAGGGTAQGPRLVLSAPNAVTNVHVAAPSGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVIGKKLRPDGTEVLSAGPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGAALSACPICRQPIRDRIQIFV", "length": 955 }, "evidence": [ { "id": "E1BBN5", "url": "https://omabrowser.org/oma/group/E1BBN5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7F972-1", "protein_name": "E3 ubiquitin-protein ligase MIB2", "gene_name": "Mib2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDLDPHAGVQVGMRVVRGMDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGIRHPNIICDCCKKHGLRGMRWKCRVCFDYDLCTQCYMHNKHDLTHAFERYETSHSRPVTLSPRQGLPRVPLRGIFQGAKVVRGPDWEWGSQDGGEGKTGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYKEHLPKLGKPAELQRRVSADGQPFQRGDKVKCLLDTDVLRDMQEGHGGWNPRMAEFIGQMGTVHRITDRGDVRVQFNHETRWTFHPGALTKHNSFWVGDVVRVIDDLDTAKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVGGQRWTFSPSCLVAYRPEEDANLDVAERSRENKSAASAPVAGGRQGSPWPALTSTLPPGSLSVALDKLRAQKSDPEHPGRLVVEAALGNVARALDLLRRHPEQVDTKNQGRTALQVAAYLGQVELVRLLLQARASVDLLDDEGNTALHYAALGNQPEATRVLLSAGCGVDARNGTRSTALHVAVQRGFLEVVKTLCERGCDVNLPDAHADTPLHSAISAGAGASSIVEVLTEVPGIDVTATNSQGFTLLHHASLKGHVLAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQVLIREGRCDVNVRNRKLQSPLHLAVQQAHLGLVPLLVDAGCSVNTEDEEGDTALHVALQRHQLLPLVADRAGGDPGPLQLLSRLQASGLPGSTELTVGAAVACFLALEGADISYANHRGRSPLDLATEGRVLKALQGCAQRFRERQAGGGGGMPPGPRHVLSTPNTVTNLHVSGTAGPDAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVISKKLRPDGSEVVNTIQVPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGAALNACPICRQPIRDRIQIFV", "length": 982 }, "evidence": [ { "id": "E1BBN5", "url": "https://omabrowser.org/oma/group/E1BBN5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q68LP1-1", "protein_name": "E3 ubiquitin-protein ligase MIB2", "gene_name": "Mib2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDLDPHAGVQVGMRVVRGMDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGIRHPNIICDCCKKHGLRGMRWKCRVCFDYDLCTQCYMHNKHDLTHAFERYETSHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKTGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYKEHLPKLGKPAELQRRVSADGQPFQRGDKVKCLLDTDVLRDMQEGHGGWNPRMAEFIGQMGTVHRITDRGDVRVQFNHETRWTFHPGALTKHNSFWVGDVVRVIDDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVGGQRWTFSPACLVACRPEEDANLGVAERARENKSAASVPVAGSLSVALDKLRTQKSDPEHPGRLVVEAALGNVARALDLLRRHPEQAGFHPAVDTKNQGRTALQVAAYLGQVELVRLLLQARASVDLLDEEGNTALHYTAMGNQPEATRLLLSAGCGVDAQNGTRSTALHVAVQRGFLEVVKILCEHGCDVNLPDAHADTPLHSAISAGAGASSIVEVLTEVPGIDVTATNSQGFTLLHHASLKGHVLAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQVLIREGRCDVNVRNRKLQSPLHLAVQQAHLGLVPLLVDAGCNVNTEDEEGDTALHVALQRHQLLPLVADRAGGDPGPLQLLSRLQASGLPGSTELTVGAAVACFLALEGADVSYANHRGRSPLDLATEGRVLKALQGCAQRFRERQAGGGGGVPPGPRHVLSTPNTVTNLHVSGTAGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVIISKKLRPDGSEVVNAIQVPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGAALNACPICRQPIRDRIQIFV", "length": 971 }, "evidence": [ { "id": "E1BBN5", "url": "https://omabrowser.org/oma/group/E1BBN5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R516-1", "protein_name": "E3 ubiquitin-protein ligase MIB2", "gene_name": "Mib2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDLDPHAGVQVGMRVVRGMDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGIRHPNIICDCCKKHGLRGMRWKCRVCFDYDLCTQCYMHNKHDLTHAFERYETSHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKTGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLRCVGEAAGGFYYKEHLPKLGKPAELQRRVSADGQPFQRGDKVKCLLDTDVLRDMQEGHGGWNPRMAEFIGQMGTVHRITDRGDVRVQFNHETRWTFHPGALTKHNSFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVGGQRWTFSPSCLVAYRPEEDANLDVAERARENKSAASVSVAGSLSVALDKLRTQKSDPEHPGRLVVEAALGNVARALDLLRRHPEQASYHPALVVDTKNQGRTALQVAAYLGQVELVRLLLQARASMDLPDDEGNTVLHYTAMGNQPEATRVLLSAGCAVDARNGTRSTALHVAVQRGFLEVVKILCERGCDVNLPDAHADTPLHSAISAGAGASSIVEVLTEVPGIDVTATNSQGFTLLHHASLKGHVLAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQVLIREGRCDVNVRNRKLQSPLHLAVQQAHLGLVPLLVDAGCSVNTEDEEGDTALHVALQRHQLLPLVADRAGGDPGPLQLLSRLQASGLPGCTELTVGAAVACFLALEGADVSYANHRGRSPLDLATEGRVLKALQGCAQRFRERQAGGGGGVPPGPRHVLSTPNTVTNLHVSGTAGPEAAECLVCSELALLILFSPCQHRTVCEECARRMKKCIRCQVVISKKLRPDGSEVVNAIQVPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGAALNACPICRQPIRDRIQIFV", "length": 973 }, "evidence": [ { "id": "E1BBN5", "url": "https://omabrowser.org/oma/group/E1BBN5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96AX9-1", "protein_name": "E3 ubiquitin-protein ligase MIB2", "gene_name": "MIB2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDVLREMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSKKLRPDGSEVASAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV", "length": 955 }, "evidence": [ { "id": "E1BBN5", "url": "https://omabrowser.org/oma/group/E1BBN5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VJ14-1", "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "mib2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MRASIPPGIRVVRGPNWIWSNQDDGEGHVGTVCEIGRCGSTHSPENTVVVNWDSGHRTNYRVGYQNQYDLIIVDNAQVGVRHSNVVCDGCSKAGIAGIVFKCAQCPNYHLCAYCYAEDLHDIEHPFIRYTTPNSLGVRLPMRKGAKRIQLRGIFVGSKVVRGPDWEWNEQDGGEGRTGRVMEIRGWDNESCRSVANVAWVTGSTNVYRLGHKGNVDLKYITATCGGHYYKDHMPVLGQTEELQPVAPMVKPSFSVGDRVKVCLEVDALMKLQQGHGGWNPRMVEHLSKLGTVHRITDKGDIRVQYENCPNRWTFHPAALVKVVSFRVGDLVTIINDANKVQQLQKGHGEWIEIMRHALGKICKVVKVYSDGDLRIQQLDDGFEWTLNPKCVKLERSPLATAAERSNSMMDLSHRRADHVMTPLSGLSGSSVADKLVREAAQGHLDFVRQYLDVNPSQVDVMSGGKACIQVASHQGYVDLVSYLISKGANVNAVDKEGDSALHYAAFGNQPATMRVLLQHGAEVNFLNSSHCSALHICAHKKTPHCVRELLQHNANVNIQDSYGDTALHDAIGKENTEVVELLCNAPNLDFTVKNNRGFNVLHHAALKGNVVAARRILLLSRQLVNVRKDDGFAALHLAALNGHAQVVETLVTEGQAELDIRNNRQQTPFLLAVSQGHAGVIERLVRLSCDVNAKDEDGDNAMHLCVIKKSNLQSAAEPQPEEAPEIHKFYLSLVHSSIRPEDRLMYSILIYLSRAGCRVELNNANASIFEWITDRHIRQLIFGQQGEAESLPRNLQALEVSAGSADGEESSASAGAESNGAGPGSVAAPPPPQRQTFELMPKPNDIPAIGVGASPSTPSASPGVKKLNSDATPQNVSPQVAPRKKAPKPPVTTSSSSTALEAGAAGPSTSPVIVPGPHECIVCNEILPMVRFEPCQHQIACEECGIRMKKCLRCAVAIERRLTVSGRVVALPTSTSSPSDPTRLPSGDLLRYLENKVLEFEESHFCGICMERKRDVAFLCGHGACSHCAETLRTCHMCRKTILKKINLY", "length": 1049 }, "evidence": [ { "id": "E1BBN5", "url": "https://omabrowser.org/oma/group/E1BBN5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "E1BBN5", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BBN5", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "E1BBN5", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "E1BBN5", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BBN5", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "E1BBN5", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BBN5", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ], "pmid": "" }, { "name": "ubiquitin ligase complex", "id": "GO:0000151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000151", "evidence": [ { "database": "UniProtKB", "id": "E1BBN5", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "E1BBN5", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ], "pmid": "" }, { "name": "Notch signaling pathway", "id": "GO:0007219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", "evidence": [ { "database": "UniProtKB", "id": "E1BBN5", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 412, "end_pos": 414, "annotation": "n_glycosylation_sequon" }, { "start_pos": 528, "end_pos": 530, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-83582", "name": "TRADD:TRAF2:RIP1 dissociates from TNF-:TNFR1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9TWW0-1", "A0ABI0NI58-1", "F1MQ36-1", "Q1RMU2-1", "E1BMK3-1", "E1B9D9-1", "E1BBN5-1" ], "evidence": [ { "id": "R-BTA-83582", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-83582" } ] }, { "id": "R-BTA-9796342", "name": "MIB2 binds RIPK1 within TNF-:TNFR1:TRADD:RIPK1:TRAF2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2TA10-1", "E1B9D9-1", "E1BBN5-1" ], "evidence": [ { "id": "R-BTA-9796342", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9796342" } ] }, { "id": "R-BTA-9796346", "name": "MIB2 ubiquitinates RIPK1 at K377, K604, K634", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2TA10-1", "E1B9D9-1", "E1BBN5-1" ], "evidence": [ { "id": "R-BTA-9796346", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9796346" } ] }, { "id": "R-BTA-9796617", "name": "MIB2 binds CFLAR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2TA10-1", "E1BBN5-1" ], "evidence": [ { "id": "R-BTA-9796617", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9796617" } ] }, { "id": "R-BTA-9796626", "name": "MIB2 ubiquitinates CFLAR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2TA10-1", "E1BBN5-1" ], "evidence": [ { "id": "R-BTA-9796626", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9796626" } ] }, { "id": "R-BTA-9815507", "name": "MIB2 ubiquitinates CYLD at K338, K530", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q1RMX2-1", "Q2TA10-1", "Q1RMU2-1", "E1BBN5-1" ], "evidence": [ { "id": "R-BTA-9815507", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9815507" } ] }, { "id": "R-BTA-9815510", "name": "MIB2 binds CYLD", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q1RMX2-1", "Q1RMU2-1", "E1BBN5-1" ], "evidence": [ { "id": "R-BTA-9815510", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9815510" } ] }, { "id": "R-BTA-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983140" } ] }, { "id": "R-BTA-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1A4I9-1", "E1BJS7-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q1JQA1-1", "Q29RQ5-1", "Q32LN5-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0AAA9RXI4-1", "Q4U5R4-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983147" } ] }, { "id": "R-BTA-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983156" } ] }, { "id": "R-BTA-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983157" } ] }, { "id": "R-BTA-9931430", "name": "MIB2-mediated K63-ubiquitination of CD274", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi membrane", "input_participant_list": [ "R-BTA-9931289" ], "output_participant_list": [ "R-BTA-9931435" ], "enzyme_list": [ "E1BBN5-1" ], "evidence": [ { "id": "R-BTA-9931430", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931430" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-9931289", "participant_name": "CD274 [Golgi membrane]", "crossref": [ { "id": "C5NU11", "database": "UniProt", "url": "" }, { "id": "NP_001156884.1", "database": "RefSeq", "url": "" }, { "id": "27019", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-9931435", "participant_name": "CD274 [Golgi membrane]", "crossref": [ { "id": "27019", "database": "VGNC", "url": "" }, { "id": "C5NU11", "database": "UniProt", "url": "" }, { "id": "NP_001156884.1", "database": "RefSeq", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1MAR8", "gene_name": "UBE2E1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] } ] }, { "uniprot_ac": "A0A3Q1MLB6", "gene_name": "UBE2R2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] } ] }, { "uniprot_ac": "A0A3Q1MLH2", "gene_name": "RNF144B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] } ] }, { "uniprot_ac": "A0A3Q1N3G7", "gene_name": "TRIM36", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] } ] }, { "uniprot_ac": "A0AAA9RXI4", "gene_name": "MGRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] } ] }, { "uniprot_ac": "A0AAA9RXX2", "gene_name": "RBBP6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] } ] }, { "uniprot_ac": "A0AAA9RZ14", "gene_name": "ITCH", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] } ] }, { "uniprot_ac": "A0AAA9S100", "gene_name": "MKRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] } ] }, { "uniprot_ac": "A0AAA9TKS8", "gene_name": "RNF217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] } ] }, { "uniprot_ac": "A0AAA9TWH7", "gene_name": "SMURF2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAF6DMH9", "gene_name": "RNF130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] } ] }, { "uniprot_ac": "A0ABI0NI58", "gene_name": "XIAP", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0ABI0NI58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NI58" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0ABI0NI58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NI58" } ] } ] }, { "uniprot_ac": "A0ABI0NWC8", "gene_name": "UBE2Q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] } ] }, { "uniprot_ac": "A0JN74", "gene_name": "TRIM11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] } ] }, { "uniprot_ac": "A1A4I9", "gene_name": "UFL1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "A1A4I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I9" } ] } ] }, { "uniprot_ac": "A3KN22", "gene_name": "UBE2M", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] } ] }, { "uniprot_ac": "A5D7F8", "gene_name": "SH3RF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] } ] }, { "uniprot_ac": "A5PJC4", "gene_name": "UBE2L6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] } ] }, { "uniprot_ac": "A5PKG6", "gene_name": "UBE4A", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] } ] }, { "uniprot_ac": "A6H795", "gene_name": "UBE2W", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] } ] }, { "uniprot_ac": "E1B782", "gene_name": "HERC2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] } ] }, { "uniprot_ac": "E1B7D3", "gene_name": "TRIM39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] } ] }, { "uniprot_ac": "E1B7G3", "gene_name": "STUB1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] } ] }, { "uniprot_ac": "E1B7Q7", "gene_name": "TRIP12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] } ] }, { "uniprot_ac": "E1B8R6", "gene_name": "ARIH2", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] } ] }, { "uniprot_ac": "E1B9D9", "gene_name": "TRAF2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B9D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9D9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B9D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9D9" } ] } ] }, { "uniprot_ac": "E1BAV2", "gene_name": "HERC4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] } ] }, { "uniprot_ac": "E1BBN5", "gene_name": "MIB2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] } ] }, { "uniprot_ac": "E1BBY2", "gene_name": "TRIM41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] } ] }, { "uniprot_ac": "E1BCU1", "gene_name": "UBE3B", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] } ] }, { "uniprot_ac": "E1BCW1", "gene_name": "UBR2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] } ] }, { "uniprot_ac": "E1BH71", "gene_name": "DTX3L", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] } ] }, { "uniprot_ac": "E1BID7", "gene_name": "TRIM69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] } ] }, { "uniprot_ac": "E1BIP5", "gene_name": "RNF19A", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] } ] }, { "uniprot_ac": "E1BIW0", "gene_name": "UBR1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] } ] }, { "uniprot_ac": "E1BJS7", "gene_name": "TRIM71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] } ] }, { "uniprot_ac": "E1BL26", "gene_name": "RNF123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] } ] }, { "uniprot_ac": "E1BMK3", "gene_name": "RNF31", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1BMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMK3" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1BMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMK3" } ] } ] }, { "uniprot_ac": "E1BNQ6", "gene_name": "TRIM50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] } ] }, { "uniprot_ac": "E1BNY9", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] } ] }, { "uniprot_ac": "F1MBM6", "gene_name": "SIAH2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] } ] }, { "uniprot_ac": "F1MEX6", "gene_name": "RNF19B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] } ] }, { "uniprot_ac": "F1MJ10", "gene_name": "NEDD4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] } ] }, { "uniprot_ac": "F1MJS5", "gene_name": "HECTD3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] } ] }, { "uniprot_ac": "F1MLS5", "gene_name": "SMURF1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] } ] }, { "uniprot_ac": "F1MM41", "gene_name": "ZNRF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] } ] }, { "uniprot_ac": "F1MQ36", "gene_name": "IKBKE", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ36" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "F1MQ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ36" } ] } ] }, { "uniprot_ac": "F1MTS8", "gene_name": "LTN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] } ] }, { "uniprot_ac": "F1MWS4", "gene_name": "RNF25", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] } ] }, { "uniprot_ac": "F1MYL0", "gene_name": "RNF220", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] } ] }, { "uniprot_ac": "F1N1X8", "gene_name": "UBE2Z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] } ] }, { "uniprot_ac": "F1N3I3", "gene_name": "UBE2O", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] } ] }, { "uniprot_ac": "F1N495", "gene_name": "AREL1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] } ] }, { "uniprot_ac": "F1N5G3", "gene_name": "SIAH1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] } ] }, { "uniprot_ac": "F1N645", "gene_name": "HECW2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] } ] }, { "uniprot_ac": "F1N6G5", "gene_name": "HACE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] } ] }, { "uniprot_ac": "F1N703", "gene_name": "UBE3C", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] } ] }, { "uniprot_ac": "F1N7A0", "gene_name": "HECTD2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] } ] }, { "uniprot_ac": "P61085", "gene_name": "UBE2K", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] } ] }, { "uniprot_ac": "Q0II22", "gene_name": "RNF126", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] } ] }, { "uniprot_ac": "Q0P5K3", "gene_name": "UBE2N", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] } ] }, { "uniprot_ac": "Q17QG5", "gene_name": "UBE2G2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] } ] }, { "uniprot_ac": "Q1JQA1", "gene_name": "UBE3D", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] } ] }, { "uniprot_ac": "Q1RML1", "gene_name": "UBE2S", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] } ] }, { "uniprot_ac": "Q1RMU2", "gene_name": "CYLD", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "Q1RMU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMU2" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "Q1RMU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMU2" } ] } ] }, { "uniprot_ac": "Q1RMW1", "gene_name": "UBE2F", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] } ] }, { "uniprot_ac": "Q1RMX2", "gene_name": "UBE2D2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] } ] }, { "uniprot_ac": "Q29RQ5", "gene_name": "TRIM9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] } ] }, { "uniprot_ac": "Q2T9X7", "gene_name": "UBE2E3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] } ] }, { "uniprot_ac": "Q2TA03", "gene_name": "UBE2J2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] } ] }, { "uniprot_ac": "Q2TA10", "gene_name": "UBE2D1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] } ] }, { "uniprot_ac": "Q32L27", "gene_name": "UBE2Q2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] } ] }, { "uniprot_ac": "Q32LN1", "gene_name": "UBE2H", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] } ] }, { "uniprot_ac": "Q32LN5", "gene_name": "RNF138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] } ] }, { "uniprot_ac": "Q32P99", "gene_name": "UBE2B", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] } ] }, { "uniprot_ac": "Q32PA5", "gene_name": "UBE2C", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] } ] }, { "uniprot_ac": "Q3MHP1", "gene_name": "UBE2L3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] } ] }, { "uniprot_ac": "Q4U5R4", "gene_name": "RNF114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] } ] }, { "uniprot_ac": "Q5E9J6", "gene_name": "RNF34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] } ] }, { "uniprot_ac": "Q7YRV4", "gene_name": "TRIM21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRV4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRV4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBN5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 959, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBN5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBN5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" }, { "id": "PS51416", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51416" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MIB/HERC2", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 80, "start_aa": "Met", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 836, "end_pos": 871, "start_aa": "Cys", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" }, { "id": "PS50135", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50135" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ZZ-type", "eco_id": "ECO_0000259", "start_pos": 86, "end_pos": 138, "start_aa": "His", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 47 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 412, "end_pos": 414 }, { "start_pos": 528, "end_pos": 530 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A7YY46-1", "uniprot_ac": "A7YY46", "uniprot_id": "PNKD_BOVIN", "mass": { "chemical_mass": 42885.0, "monoisotopic_mass": 42885.0 }, "refseq": { "ac": "NP_001107642", "name": "probable thioesterase PNKD isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107642" }, "gene_names": [ { "name": "PNKD", "type": "recommended", "evidence": [ { "id": "A7YY46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YY46" } ] }, { "name": "PNKD", "type": "synonym", "evidence": [ { "id": "NP_001107642", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107642" } ] } ], "protein_names": [ { "name": "Probable thioesterase PNKD", "type": "recommended", "evidence": [ { "id": "A7YY46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YY46/entry#names_and_taxonomy" } ] }, { "name": "3.1.2.-", "type": "synonym", "evidence": [ { "id": "A7YY46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YY46/entry#names_and_taxonomy" } ] }, { "name": "PNKD, MBL domain containing", "type": "synonym", "evidence": [ { "id": "NP_001107642", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107642" } ] }, { "name": "paroxysmal nonkinesigenic dyskinesia", "type": "synonym", "evidence": [ { "id": "NP_001107642", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107642" } ] }, { "name": "paroxysmal nonkinesiogenic dyskinesia", "type": "synonym", "evidence": [ { "id": "NP_001107642", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107642" } ] }, { "name": "probable hydrolase PNKD", "type": "synonym", "evidence": [ { "id": "NP_001107642", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107642" } ] }, { "name": "probable thioesterase PNKD isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001107642", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107642" } ] }, { "name": "probable thioesterase PNKD", "type": "synonym", "evidence": [ { "id": "NP_001107642", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107642" } ] } ], "function": [ { "annotation": "Probable thioesterase that may play a role in cellular detoxification processes; it likely acts on a yet-unknown alpha-hydroxythioester substrate. In vitro, it is able to catalyze the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid at very low rate, though this reaction is not physiologically relevant in vivo.", "evidence": [ { "database": "UniProtKB", "id": "A0A452DI30", "url": "https://www.uniprot.org/uniprotkb/A0A452DI30#function" }, { "database": "UniProtKB", "id": "ARBA00055224", "url": "https://www.uniprot.org/uniprotkb/ARBA00055224#function" }, { "database": "UniProtKB", "id": "A7YY46", "url": "https://www.uniprot.org/uniprotkb/A7YY46#function" }, { "database": "UniProtKB", "id": "Q8N490", "url": "https://www.uniprot.org/uniprotkb/Q8N490#function" }, { "database": "UniProtKB", "id": "A0AAA9SR04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR04#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7YY46", "url": "https://www.uniprot.org/uniprotkb/A7YY46" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PNKD", "url": "https://www.uniprot.org/uniprotkb/A7YY46", "locus": { "chromosome": "2", "start_pos": 106371799, "end_pos": 106298913, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003936", "url": "https://www.ensembl.org/id/ENSBTAG00000003936" } ] } } ], "crossref": [ { "id": "A7YY46", "url": "https://alphafold.ebi.ac.uk/entry/A7YY46", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003936", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003936", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07723", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07723", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616561", "url": "https://www.ncbi.nlm.nih.gov/gene/616561", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001279", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001279", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017782", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017782", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031833", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031833", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036866", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036866", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616561", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616561", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CVWPGMR", "url": "https://omabrowser.org/oma/group/CVWPGMR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DI30", "url": "https://www.orthodb.org/?gene=A0A452DI30", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A7YY46", "url": "https://www.orthodb.org/?gene=A7YY46", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11935", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11935", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11935:SF116", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11935:SF116", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00753", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00753", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15932", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15932", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16123", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16123", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001107642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107642", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "82919", "url": "https://www.rhea-db.org/rhea/82919", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DI30", "url": "https://www.uniprot.org/uniprotkb/A0A452DI30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DI30-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DI30-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR04-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7YY46", "url": "https://www.uniprot.org/uniprotkb/A7YY46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7YY46-1", "url": "https://www.uniprot.org/uniprotkb/A7YY46-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAVVAATALKGRGARNARVLRGILSGATANKASQNRSRALQSHSSPECKEEPEPLSPELEYIPRKRGKNPMKAVGLAWYSLYTRTRLGYLFYRQQLRRARNRYPKGHSRTQPRLFNGVKVLPIPVLSDNYSYLIIDTQARLAVAVDPSDPQAVQASIEKEGVNLVAILCTHKHWDHSGGNRDLSRRHQDCRVYGSPQDSIPYLTHPLCHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYEGPSCLFSGDLLFLSGCGRTFEGTAETMLSSLDTVLGLGDDTLLWPGHEYAEENLGFAGVVEPENLARERKMQWVQRQRMERKSTCPSTLGEERSYNPFLRTHCLVLQEALGPSPGPTGDDGCSRAQLLERLRQLKDLHKSK", "length": 385, "header": "sp|A7YY46-1|PNKD_BOVIN Isoform 1 of Probable thioesterase PNKD OS=Bos taurus OX=9913 GN=PNKD PE=2 SV=1 CANONICAL=A7YY46-1" }, "isoforms": [ { "isoform_ac": "A0A452DI30-1", "url": "https://www.uniprot.org/uniprotkb/A7YY46/entry#A0A452DI30-1", "sequence": { "sequence": "MAWRGWPASWLWVASCGLLLLVFVLLLSPRSCRARRTLRGLFMARSKRLLFRIGYSLYTRTRLGYLFYRQQLRRARNRYPKGHSRTQPRLFNGVKVLPIPVLSDNYSYLIIDTQARLAVAVDPSDPQAVQASIEKEGVNLVAILCTHKHWDHSGGNRDLSRRHQDCRVYGSPQDSIPYLTHPLCHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYEGPSCLFSGDLLFLSGCGRTFEGTAETMLSSLDTVLGLGDDTLLWPGHEYAEENLGFAGVVEPENLARERKMQWVQRQRMERKSTCPSTLGEERSYNPFLRTHCLVLQEALGPSPGPTGDDGCSRAQLLERLRQLKDLHKSK", "length": 360, "header": "tr|A0A452DI30-1|PNKD_BOVIN Computationally mapped isoform of Probable thioesterase PNKD OS=Bos taurus OX=9913 GN=PNKD PE=2 SV=1 CANONICAL=A7YY46-1" }, "locus": { "chromosome": "2", "start_pos": 106370022, "end_pos": 106348916, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005141.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005141.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005141.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005141.5" } ] } }, { "isoform_ac": "A0AAA9SIA6-1", "url": "https://www.uniprot.org/uniprotkb/A7YY46/entry#A0AAA9SIA6-1", "sequence": { "sequence": "MAWRGWPASWLWVASCGLLLLVFVLLLSPRSCRARRTLRGLFMARSKRLLFRIGDHSGGNRDLSRRHQDCRVYGSPQDSIPYLTHPLCHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYEGPSCLFSGDLLFLSGCGRTFEGTAETMLSSLDTVLGLGDDTLLWPGHEYAEENLGFAGVVEPENLARERKMQWVQRQRMERKSTCPSTLGEERSYNPFLRTHCLVLQEALGPSPGPTGDDGCSRAQLLERLRQLKDLHKSK", "length": 264, "header": "tr|A0AAA9SIA6-1|PNKD_BOVIN Computationally mapped isoform of Probable thioesterase PNKD OS=Bos taurus OX=9913 GN=PNKD PE=2 SV=1 CANONICAL=A7YY46-1" }, "locus": { "chromosome": "2", "start_pos": 106370022, "end_pos": 106348916, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118600.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118600.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083479.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083479.1" } ] } }, { "isoform_ac": "A0AAA9SR04-1", "url": "https://www.uniprot.org/uniprotkb/A7YY46/entry#A0AAA9SR04-1", "sequence": { "sequence": "MAAVVAATALKGRGARNARVLRGILSGATANKASQNRSRALQSHSSPECKEEPEPLSPELEYIPRKRGKNPMKAVGLAWAIGFPCGILLFILTKREVDKDRLKQMKARQNMRASNTGEYSLYTRTRLGYLFYRQQLRRARNRYPKGHSRTQPRLFNGVKVLPIPVLSDNYSYLIIDTQARLAVAVDPSDPQAVQASIEKEGVNLVAILCTHKHWDHSGGNRDLSRRHQDCRVYGSPQDSIPYLTHPLCHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYEGPSCLFSGDLLFLSGCGRTFEGTAETMLSSLDTVLGLGDDTLLWPGHEYAEENLGFAGVVEPENLARERKMQWVQRQRMERKSTCPSTLGEERSYNPFLRTHCLVLQEALGPSPGPTGDDGCSRAQLLERLRQLKDLHKSK", "length": 424, "header": "tr|A0AAA9SR04-1|PNKD_BOVIN Computationally mapped isoform of Probable thioesterase PNKD OS=Bos taurus OX=9913 GN=PNKD PE=2 SV=1 CANONICAL=A7YY46-1" }, "locus": { "chromosome": "2", "start_pos": 106370022, "end_pos": 106298915, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103244.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103244.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088773.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088773.1" } ] } }, { "isoform_ac": "A7YY46-1", "url": "https://www.uniprot.org/uniprotkb/A7YY46/entry#A7YY46-1", "sequence": { "sequence": "MAAVVAATALKGRGARNARVLRGILSGATANKASQNRSRALQSHSSPECKEEPEPLSPELEYIPRKRGKNPMKAVGLAWYSLYTRTRLGYLFYRQQLRRARNRYPKGHSRTQPRLFNGVKVLPIPVLSDNYSYLIIDTQARLAVAVDPSDPQAVQASIEKEGVNLVAILCTHKHWDHSGGNRDLSRRHQDCRVYGSPQDSIPYLTHPLCHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYEGPSCLFSGDLLFLSGCGRTFEGTAETMLSSLDTVLGLGDDTLLWPGHEYAEENLGFAGVVEPENLARERKMQWVQRQRMERKSTCPSTLGEERSYNPFLRTHCLVLQEALGPSPGPTGDDGCSRAQLLERLRQLKDLHKSK", "length": 385, "header": "sp|A7YY46-1|PNKD_BOVIN Isoform 1 of Probable thioesterase PNKD OS=Bos taurus OX=9913 GN=PNKD PE=2 SV=1 CANONICAL=A7YY46-1" }, "locus": { "chromosome": "2", "start_pos": 106370022, "end_pos": 106298915, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125289.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125289.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083759.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083759.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 226, "start_aa": "Thr", "end_pos": 226, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr226", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 361, "start_aa": "Thr", "end_pos": 361, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr361", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616561", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616561", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZXB0-1", "protein_name": "Probable thioesterase PNKD", "gene_name": "Pnkd", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAVVAATALKGRGARNARVLRGILSGATANKASQNRTRALQSHSSPECKEEPEPLSPELEYIPRKRGKNPMKAVGLAWAIGFPCGILFFVLTKQEVDKDRLKQMKARQNMRVSNTGEYSLYTRTWLGYLFYRQQLRRARNRFPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAGLAVAVDPSDPRAVQASIEKERVNLVAILCTHKHWDHSGGNRDLSRRHRDCRVYGSPQDGIPYLTHPLCHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYKGPSCLFSGDLLFLSGCGRTFEGTAETMLSSLDTVLDLGDDTLLWPGHEYAEENLGFAGVVEPENVARERKMQWVQRQRMERKSTCPSTLGEERAYNPFLRTHCLALQEALGPGPGPTSDDGCSRAQLLEELRRLKDMHKSK", "length": 424 }, "evidence": [ { "id": "A7YY46", "url": "https://omabrowser.org/oma/group/A7YY46/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F6NM08-1", "protein_name": "3.1.2.6", "gene_name": "pnkd", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MALPEWTVYLLCIASVCGGFYICRVVKCARKSAWKNSQIAKLMARSEKPLFWIAYSLYTRTKLGYIFHKRQMKKARERYPTGHSRAQPTIINGIKIIPVPILLDNYSYVVIDTASNTAVVVDPADPQPVQACLEAEGVALQAVLCTHKHWDHSGGNRALKRRYSSCRVYGNAMDNIPGLTHPLLDKDTIDFGTQLHFRAFYTPGHTVGHMIYLLDGRAIGGPSSLFSGDLVFLSGCGRMFEGNASTMLSSLDTVGSLNDDTLLWPGHEYAEDNLLFAADVEPGNVVREQKLQWVLQQRSQRLCTCPSTLLEEKQYNPFLRSHSQDLHQALGLQQKQDEDWTSYRARVLEELRRRKDIYKDR", "length": 361 }, "evidence": [ { "id": "A7YY46", "url": "https://omabrowser.org/oma/group/A7YY46/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3IEK8-1", "protein_name": "Probable thioesterase PNKD", "gene_name": "LOC100750526", "tax_id": 10029, "organism": 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"https://www.ebi.ac.uk/interpro/entry/IPR029717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031802", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031802", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538655", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538655", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CPYSHTA", "url": "https://omabrowser.org/oma/group/CPYSHTA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIL0", "url": "https://www.orthodb.org/?gene=A0A452DIL0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A7MB40", "url": "https://www.orthodb.org/?gene=A7MB40", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15109", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15109", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15109:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15109:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15914", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15914", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039898", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039898", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DIL0", "url": "https://www.uniprot.org/uniprotkb/A0A452DIL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIL0-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIL0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9R1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9R1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9R1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7MB40", "url": "https://www.uniprot.org/uniprotkb/A7MB40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7MB40-1", "url": "https://www.uniprot.org/uniprotkb/A7MB40-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7MB40-2", "url": "https://www.uniprot.org/uniprotkb/A7MB40-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTRRRSRPSGGAGRRERARATGPQKPQAPEPPPPPSLEAGAGAGPPEAPAEPYRDDPREEDEPKLAPGPQVPPTTSQSVQTCCLLCHRERKGWEEGPSQNGLVLQGEKLPPDFMPKLVKNLLGEMPLWVCQSCRKSMEEDERQTGREHAVAISLSHTSCKSQSCGGDSHSSSSSSSSSSSSSSSCHGNSGDWDPSSFLSAHKLSGLWNSPHSSGAMPGGSLGSPPTIPGEVFPISEHHRHSDLTAPPNSPTGHHPQPAPLIPSHPGSFGSPPHPHLLPTTPAVHFPAQVSECPVAVAAAPHTPGPCQSPHLPSTSMPLLKMPPPFSGCSHPCSGHCSGHCSGPLLPPPSSQQLPSTHSRDPGCKGHKFTHSGLTCQLPQPCEADEGLGEEEDSSSERSSCTSSSTHQRDGKFCDCCYCEFFGHNAEKEKAQLAAEALKQANRSVSGSRELRPARESLLGWPDRELDRVNSFLNSRLQEIKNTVKDSICASFSMCELSVDSNGFSKEGATEPKPQSLAPSNPSGSSEQRPDINLDLSPLTLGSPQNHMLQAPGEPAPPWAEMRSPHPPWTEVKGPPPGIIPENGLVRRLNTVPNLSRMIWVKTPKPGNPSSEEPSIKGAPGCKQELPEPVASGGKPRKGKRQGNQAKKSEVSPASQSPACLETPSAKGQTPSPKQPSKAPEPPRVDSCAEAGEGSQGTRPGPGWADSPKADKEKGNSWRNWPGEAKARPLEQESVQPPGPARPQSFQQGKGRSRRSRNKQEKSASSLDDVFLPKDMDGVEMDETDREVEYFKRFCLDSAKQTRQKVAVNWTNFSLKKTTPSTAQ", "length": 823, "header": "sp|A7MB40-1|F193B_BOVIN Isoform 1 of Protein FAM193B OS=Bos taurus OX=9913 GN=FAM193B PE=2 SV=1 CANONICAL=A7MB40-1" }, "isoforms": [ { "isoform_ac": "A0A452DIL0-1", "url": "https://www.uniprot.org/uniprotkb/A7MB40/entry#A0A452DIL0-1", "sequence": { "sequence": "MTRRRSRPSGGAGRRERARATGPQKPQAPEPPPPPSLEAGAGAGPPEAPAEPYRDDPREEDEPKLAPGPQVPPTTSQSVQTCCLLCHRERKGWEEGPSQNGLVLQGEKLPPDFMPKLVKNLLGEMPLWVCQSCRKSMEEDERQTGREHAVAISLSHTSCKSQSCGGDSHSSSSSSSSSSSSSSSCHGNSGDWDPSSFLSAHKLSGLWNSPHSSGAMPGGSLGSPPTIPGEVFPISEHHRHSDLTAPPNSPTGHHPQPAPLIPSHPGSFGSPPHPHLLPTTPAVHFPAQVSECPVAVAAAPHTPGPCQSPHLPSTSMPLLKMPPPFSGCSHPCSGHCSGHCSGPLLPPPSSQQLPSTHSRDPGCKGHKFTHSGLTCQLPQPCEADEGLGEEEDSSSERSSCTSSSTHQRDGKFCDCCYCEFFGHNAPPAAPTSRNYTEIREKLRSRLTRRKEELPMKGGALGGIPGEPAVDHRDVDELLEFINSTEPKVPNSARAAKRARHKLKKKEKEKAQLAAEALKQANRSVSGSRELRPARESLLGWPDRELDRVNSFLNSRLQEIKNTVKDSICASFSMCELSVDSNGFSKEGATEPKPQSLAPSNPSGSSEQRPDINLDLSPLTLGSPQNHMLQAPGEPAPPWAEMRSPHPPWTEVKGPPPGIIPENGLVRRLNTVPNLSRMIWVKTPKPGNPSSEEPSIKGAPGCKQELPEPVASGGKPRKGKRQGNQAKKSEVSPASQSPACLETPSAKGQTPSPKQPSKAPEPPRVDSCAEAGEGSQGTRPGPGWADSPKADKEKGNSWRNWPGEAKARPLEQESVQPPGPARPQSFQQGKGRSRRSRNKQEKSASSLDDVFLPKDMDGVEMDETDREVEYFKRFCLDSAKQTRQKVAVNWTNFSLKKTTPSTAQ", "length": 903, "header": "tr|A0A452DIL0-1|F193B_BOVIN Computationally mapped isoform of Protein FAM193B OS=Bos taurus OX=9913 GN=FAM193B PE=2 SV=1 CANONICAL=A7MB40-1" }, "locus": { "chromosome": "7", "start_pos": 39051154, "end_pos": 39022620, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020211.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020211.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020211.6", "url": "https://www.ensembl.org/id/ENSBTAP00000020211.6" } ] } }, { "isoform_ac": "A0AAA9T9R1-1", "url": "https://www.uniprot.org/uniprotkb/A7MB40/entry#A0AAA9T9R1-1", "sequence": { "sequence": "MRLALQTLHRAAGDSGRLVQPEGMALDSLLVESLELCMFPLPPASLCRLAACCVTGNAKAGKKALPRTDWCCRISLSHTSCKSQSCGGDSHSSSSSSSSSSSSSSSCHGNSGDWDPSSFLSAHKLSGLWNSPHSSGAMPGGSLGSPPTIPGEVFPISEHHRHSDLTAPPNSPTGHHPQPAPLIPSHPGSFGSPPHPHLLPTTPAVHFPAQVSECPVAVAAAPHTPGPCQSPHLPSTSMPLLKMPPPFSGCSHPCSGHCSGHCSGPLLPPPSSQQLPSTHSRDPGCKGHKFTHSGLTCQLPQPCEADEGLGEEEDSSSERSSCTSSSTHQRDGKFCDCCYCEFFGHNAPPAAPTSRNYTEIREKLRSRLTRRKEELPMKGGALGGIPGEPAVDHRDVDELLEFINSTEPKVPNSARAAKRARHKLKKKEKEKAQLAAEALKQANRSVSGSRELRPARESLLGWPDRELDRVNSFLNSRLQEIKNTVKDSICASFSMCELSVDSNGFSKEGATEPKPQSLAPSNPSGSSEQRPDINLDLSPLTLGSPQNHMLQAPGEPAPPWAEMRSPHPPWTEVKGPPPGIIPENGLVRRLNTVPNLSRMIWVKTPKPGNPSSEEPSIKGAPGCKQELPEPVASGGKPRKGKRQGNQAKKSEVSPASQSPACLETPSAKGQTPSPKQPSKAPEPPRVDSCAEAGEGSQGTRPGPGWADSPKADKEKGNSWRNWPGEAKARPLEQESVQPPGPARPQSFQQGKGRSRRSRNKQEKSASSLDDVFLPKDMDGVEMDETDREVEYFKRFCLDSAKQTRQKVAVNWTNFSLKKTTPSTAQ", "length": 825, "header": "tr|A0AAA9T9R1-1|F193B_BOVIN Computationally mapped isoform of Protein FAM193B OS=Bos taurus OX=9913 GN=FAM193B PE=2 SV=1 CANONICAL=A7MB40-1" }, "locus": { "chromosome": "7", "start_pos": 39049969, "end_pos": 39022620, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117883.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117883.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095446.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095446.1" } ] } }, { "isoform_ac": "A7MB40-1", "url": "https://www.uniprot.org/uniprotkb/A7MB40/entry#A7MB40-1", "sequence": { "sequence": "MTRRRSRPSGGAGRRERARATGPQKPQAPEPPPPPSLEAGAGAGPPEAPAEPYRDDPREEDEPKLAPGPQVPPTTSQSVQTCCLLCHRERKGWEEGPSQNGLVLQGEKLPPDFMPKLVKNLLGEMPLWVCQSCRKSMEEDERQTGREHAVAISLSHTSCKSQSCGGDSHSSSSSSSSSSSSSSSCHGNSGDWDPSSFLSAHKLSGLWNSPHSSGAMPGGSLGSPPTIPGEVFPISEHHRHSDLTAPPNSPTGHHPQPAPLIPSHPGSFGSPPHPHLLPTTPAVHFPAQVSECPVAVAAAPHTPGPCQSPHLPSTSMPLLKMPPPFSGCSHPCSGHCSGHCSGPLLPPPSSQQLPSTHSRDPGCKGHKFTHSGLTCQLPQPCEADEGLGEEEDSSSERSSCTSSSTHQRDGKFCDCCYCEFFGHNAEKEKAQLAAEALKQANRSVSGSRELRPARESLLGWPDRELDRVNSFLNSRLQEIKNTVKDSICASFSMCELSVDSNGFSKEGATEPKPQSLAPSNPSGSSEQRPDINLDLSPLTLGSPQNHMLQAPGEPAPPWAEMRSPHPPWTEVKGPPPGIIPENGLVRRLNTVPNLSRMIWVKTPKPGNPSSEEPSIKGAPGCKQELPEPVASGGKPRKGKRQGNQAKKSEVSPASQSPACLETPSAKGQTPSPKQPSKAPEPPRVDSCAEAGEGSQGTRPGPGWADSPKADKEKGNSWRNWPGEAKARPLEQESVQPPGPARPQSFQQGKGRSRRSRNKQEKSASSLDDVFLPKDMDGVEMDETDREVEYFKRFCLDSAKQTRQKVAVNWTNFSLKKTTPSTAQ", "length": 823, "header": "sp|A7MB40-1|F193B_BOVIN Isoform 1 of Protein FAM193B OS=Bos taurus OX=9913 GN=FAM193B PE=2 SV=1 CANONICAL=A7MB40-1" }, "locus": { "chromosome": "7", "start_pos": 39051154, "end_pos": 39022620, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054949.3", "url": "https://www.ensembl.org/id/ENSBTAT00000054949.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049740.1", "url": "https://www.ensembl.org/id/ENSBTAP00000049740.1" } ] } }, { "isoform_ac": "A7MB40-2", "url": "https://www.uniprot.org/uniprotkb/A7MB40/entry#A7MB40-2", "sequence": { "sequence": "MKGGALGGIPGEPAVDHRDVDELLEFINSTEPKVPNSARAAKRARHKLKKKEKEKAQLAAEALKQANRSVSGSRELRPARESLLGWPDRELDRVNSFLNSRLQEIKNTVKDSICASFSMCELSVDSNGFSKEGATEPKPQSLAPSNPSGSSEQRPDINLDLSPLTLGSPQNHMLQAPGEPAPPWAEMRSPHPPWTEVKGPPPGIIPENGLVRRLNTVPNLSRMIWVKTPKPGNPSSEEPSIKGAPGCKQELPEPVASGGKPRKGKRQGNQAKKSEVSPASQSPACLETPSAKGQTPSPKQPSKAPEPPRVDSCAEAGEGSQGTRPGPGWADSPKADKEKGNSWRNWPGEAKARPLEQESVQPPGPARPQSFQQGKGRSRRSRNKQEKSASSLDDVFLPKDMDGVEMDETDREVEYFKRFCLDSAKQTRQKVAVNWTNFSLKKTTPSTAQ", "length": 449, "header": "sp|A7MB40-2|F193B_BOVIN Isoform 2 of Protein FAM193B OS=Bos taurus OX=9913 GN=FAM193B PE=2 SV=1 CANONICAL=A7MB40-1" }, "locus": { "chromosome": "7", "start_pos": 39030785, "end_pos": 39022620, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104503.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104503.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088768.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088768.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 694, "end_pos": 694, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7MB40", "url": "https://www.uniprot.org/uniprotkb/A7MB40" } ], "site_lbl": "Ser694" }, { "start_pos": 706, "end_pos": 706, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7MB40", "url": "https://www.uniprot.org/uniprotkb/A7MB40" } ], "site_lbl": "Ser706" }, { "start_pos": 813, "end_pos": 813, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7MB40", "url": "https://www.uniprot.org/uniprotkb/A7MB40" } ], "site_lbl": "Ser813" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538655", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538655", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4ICN6-1", "protein_name": "Protein FAM193B", "gene_name": "fam193b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MARKKSKQQGTGAKDSVSVQQQQSLSKKPGDAVAGAAATGGGDAGAARTSQSMHTCCLLCHREFKDWGSGGANGLPAHGSRLAEAVPALSQALLRDAPGRTLADAVPSLSQSLLGEVPLWICQSCRRSVEEEERRTLQEQNSQVPLSHSSSCKSQSCGNGYPENSSVDWDPSSFLSARKLSGLWNSAHSNGGSHCNHNPAALSPGGTLGPACHEKRPSHDAPGKAAKTFGTKVCPYSHPASQNSSAASPGTLSASSDACKTNPKHFKTMCRRPTPPGEAFHPNDHHQSADLSVPPNSPTGLSSQHSSLLPPKQNSSQHVHVGSANSGLPSHAPFSPLVPNIHAPTAKHSSGPDSPVALHKPSACKNAHIPAVNSQHGKLSNSLIGCSHPCNGHSNGSSVASPNAGHVTPGACRDQACKGHKVPNGSLCHTSPCELEEGDDEDSSSERSSCASSSNNQKDGKYCDCCYCEFFGHNAPPAAPTSRNYAEIREKLRSRLTRRKEELPQRQDLDPAAPSAIDHRDVDELLDFINSTEPKPVNSAKAAKRARHKQKKKEKERALQCSMDAVGSDPRSASPPDPMEDSAPDADANRLLEWPQLELERVNSFLTSRLEEIKNTIKDSIRASFSMYDLNLDVNDFPKKAATLEGNHLLSHLNGSSDLQQIDLDLAPLSLRNFKRDLDIVNGWEDTTTAAKDIQRLHSTPSLSKLIRVRSPERIPAPESTQSAAKPGEALPEIKSLAGAKMKKSKKQQEVSGKSSTHKAQEIKAADCDKSTKGGCKTQQVDAQKNGNKKAEEVKVCKQTSSNGHHNTATNTQQRAKNELSDTRGSRPEHDGDTKSISNTPSAQQPKGKTKNKNKNKTEKSSNAIDDVFLPKDVDPTEMDEIDREVEYFKRFCLDSAKQTRQKVAVNWSNFSLKKMPSNAAQ", "length": 922 }, "evidence": [ { "id": "A7MB40", "url": "https://omabrowser.org/oma/group/A7MB40/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A287BHQ3-1", "protein_name": "Family with sequence similarity 193 member B", "gene_name": "FAM193B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTRRRSRPSGCAGRRERARAAGPQKPQAPEPPPPPCLEAGAGAGSPEASAEPDRDGPREDDELQLAPVPQVPPTSSQSVQTCCLLCHRERKGWEEGPSQNGLVLQGEKLPPDFMPKLVKNLLGEMPLWVCQSCRKSMEEDERQTGREHAVAISLSHTSCKSQSCGGDSHSSSSSSSSSSSSSSSCHGNSGDWDPSSFLSAHKLSGLWNSPHSSGAMPGSSLGSPPTIPGEVFPISEHHRHSDLTAPPNSPTGHHPQAASLIPSHPGSFGSPPHPHLLPTTLAAPFPAQVSECPVAAAAAPHTPGPCQSPHLPSTSMPLLKMPPPFSGCSHPCSGHCSGHCSGPLLPPPSSQQLPGTHRDPGCKGHKFPHSGLACQLPQPCEADEGLGEEEDSSSERSSCTSSSTHQRDGKFCDCCYCEFFGHNAEKEKAQLAAEALKQANRGISGSRELRPARERLLEWPDRELDRVNSFLSSRLQEIKNTVKDSIRASFSVCELSMDSNGFSKEGAAEPEPQSLTPSNLNGSSEQRPDINLDLSPLTLGSPQNHILQAPGEPAPPWAEMRSPHPPWTEVRGPPPGIIPENGLVRRLNTVPNLSRVIWVKTPKPGNPSSEEPSPQEVPGCKQELPEPLASGGKPRKGKRQGSQAKKSEVSPPQSPACLEAPSAKGQTPSPKQPGKALEPPRVDSCAEAGEGSRGAQPGPGWAGSPKADKEKGSSWRNWPGETKVRPLEQESVQPPGPARPQSLPQGKGRSRRSRNKQEKSASSLDDVFLPKDMDGAEMDETDREVEYFKRFCLDSAKQTRQKVAVNWTNFSLKKTTPSTAQ", "length": 821 }, "evidence": [ { "id": "A7MB40", "url": "https://omabrowser.org/oma/group/A7MB40/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6AF06-1", "protein_name": "Family with sequence similarity 193, member B", "gene_name": "Fam193b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTRRRSRPSGGAGRRERARTAGLQKPQAPEPQPPPSLEAGAGAGPPEVPAEQDRDGPREEDEPKLASGPQVPPASSQSVQTCCLLCHREREGWEEGPSQNGLVLQGEKLPPDFMPKLVKNLLGEMPLWVCQSCRKSMEEDERQTGGDHAVAISLSHTSCKSQSCGGDSHSSSSSSSSSSSSSSSCHGNSGDWDPSSFLSAHKLSGLWNSPHSSGAVPGSSLGSPPVIPGEAFPVSERHQHSDLTAPPNSPTGPAPHPASLIPSHPGSFSSASHPHLLPTTPAAPFPAQASECPMAAATATHPPGPCQSPHLPSTSMPLLKMPPPLPGCSHPCSGHCSGHCGGPLLPPPSSQPLPSTHSRDPGCKGHKFAHSGLACEADEGLGEEEDSSSERSSCTSSSTHPRDGKFCDCCYCEFFGHNAEKEKARLATEALKQVNRVSGSQEPRPARERLLEWPDQELDRVSSFLSSRLQEIKSTVKDSLCASLNMCELGMDSSGFKEGTMEAQTLTPSDLSGSSQKQPDINLDLSPLTLGSPQSHTLQAPSEPVPPWAERRDPHPPWTEVRGPPPAIPENGLVRRLNTVPNLSRVIWVKTPKPGKPSSEESPKEVPICKQERSEPVATGGKPRKSKRQGSQAKKTEASPAPWPPANQEAPSAKSQMSSPKQPGKGPEPAKAGSAAEPGEGSRGSRPGPIQAASPKTDKKGSSWQNWPGGARARTLEQESEQIPGPAKPQSLSQGKGRSRRSRNKQEKSASSLDDVFLPKDLDGVEMDETDREVEYFKRFCLDSAKQTRQKVAVNWTNFSLKKTAPSTAQ", "length": 810 }, "evidence": [ { "id": "A7MB40", "url": "https://omabrowser.org/oma/group/A7MB40/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3U2K0-1", "protein_name": "Protein FAM193B", "gene_name": "Fam193b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTRRRSRPSGGAGRRERARAAGLQKPQAPEPQPPPPSLEAGAGAGPPEVPAELDCDGPREEEEPKLAPGPQVPPTSSQSVQTCCLLCHRERKGWEEGPSQNGLVLQGEKLPPDFMPKLVKNLLGEMPLWVCQSCRKSMEEEERQTGGDHAVAISLSHTSCKSQSCGGDSHSSSSSSSSSSSSSSSCHGNSGDWDPSSFLSAHKLSGLWNSPHSSGAVPGSSLGSPPAILGEAFPVSEHHQHSDLTAPPNSPTGPPPHPASLIPSHPGSFSSASYPPPLPTTPVAPFPAQASECPMAAATATHPSGPCQSPHPPSTSMPLLKMPPPLSGCSHPCSGHCSGHCGGPLLPPPSSQPLPSTHSRDPGCKGHKFAHSGLACEADEGLGEEEDSSSERSSCTSSSTHPRDGKFCDCCYCEFFGHNAPLAAPTSRNYTEIREKLRSRLTRRKEELPMKGGTLGGIPGEPAVDHRDVDELLEFINSTEPKVPNSARAAKRARHKLKKKEKEKARLATEALKQVNRVSGSQEPRPARERLLEWPDQELDRVNSFLSSRLQEIKSTVKDSLCASLSMCELSVESSGFKEGTVEAQTLTPSDLSGSSQKRPDINLDLSPLTLGSPQSHTLQAPSEPVPPWAERRDPHPPPWTEVRGPPPGIPENGLVRRLNTVPNLSRVIWVKTPKPGNPSSEESSKEVPSCKQELSEPVATGGKPKKSKRQGSQAKKTLASPAPWSPANLEASGAKSQVSSPKQPSKGSEPAKVGSGAEPGEGSPGSRPGPIQADSPKTDKKGSSWQNWPGGAKARTLEQESEQTPGPARPQSLSQGKGRSRRSRNKQEKSASSLDDVFLPKDLDGVEMDETDREVEYFKRFCLDSAKQTRQKVAVNWTNFSLKKTTPSTAQ", "length": 892 }, "evidence": [ { "id": "A7MB40", "url": "https://omabrowser.org/oma/group/A7MB40/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96PV7-1", "protein_name": "Protein FAM193B", "gene_name": "FAM193B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTRRRSRPSGGAGRRERARAAGPQKPQAPEPPPPPSLEAGAGAGPPEAPAEPDHDGPREDDEPNLVPGPQVPPASSQPVQTCCLLCHRERKGWEEGPSQNGLVLQGEKLPPDFMPKLVKNLLGEMPLWVCQSCRKSMEEDERQTGREHAVAISLSHTSCKSQSCGDDSHSSSSSSSSSSSSSSSSCPGNSGDWDPSSFLSAHKLSGLWNSPHSSGAMPGSSLGSPPTIPGEAFPVSEHHQHSDLTAPPNSPTGHHPQPASLIPSHPSSFGSPPHPHLLPTTPAAPFPAQASECPVAAATAPHTPGPCQSSHLPSTSMPLLKMPPPFSGCSHPCSGHCGGHCSGPLLPPPSSQPLPSTHRDPGCKGHKFAHSGLACQLPQPCEADEGLGEEEDSSSERSSCTSSSTHQRDGKFCDCCYCEFFGHNAPPAAPTSRNYTEIREKLRSRLTRRKEELPMKGGTLGGIPGEPAVDHRDVDELLEFINSTEPKVPNSARAAKRARHKLKKKEKEKAQLAAEALKQANRVSGSREPRPARERLLEWPDRELDRVNSFLSSRLQEIKNTVKDSIRASFSVCELSMDSNGFSKEGAAEPEPQSLPPSNLSGSSEQQPDINLDLSPLTLGSPQNHTLQAPGEPAPPWAEMRGPHPPWTEVRGPPPGIVPENGLVRRLNTVPNLSRVIWVKTPKPGYPSSEEPSSKEVPSCKQELPEPVSSGGKPQKGKRQGSQAKKSEASPAPRPPASLEVPSAKGQVAGPKQPGRVLELPKVGSCAEAGEGSRGSRPGPGWAGSPKTEKEKGSSWRNWPGEAKARPQEQESVQPSGPARPQSLPQGKGRSRRSRNKQEKPASSLDDVFLPKDMDGVEMDETDREVEYFKRFCLDSAKQTRQKVAVNWTNFSLKKTTPSTAQ", "length": 902 }, "evidence": [ { "id": "A7MB40", "url": "https://omabrowser.org/oma/group/A7MB40/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A7MB40", "url": "https://www.uniprot.org/uniprotkb/A7MB40" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A7MB40", "url": "https://www.uniprot.org/uniprotkb/A7MB40" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A7MB40", "url": "https://www.uniprot.org/uniprotkb/A7MB40" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A7MB40", "url": "https://www.uniprot.org/uniprotkb/A7MB40" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 441, "end_pos": 443, "annotation": "n_glycosylation_sequon" }, { "start_pos": 593, "end_pos": 595, "annotation": "n_glycosylation_sequon" }, { "start_pos": 808, "end_pos": 810, "annotation": "n_glycosylation_sequon" }, { "start_pos": 811, "end_pos": 813, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7MB40-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 823, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7MB40-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7MB40" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 694, 706, 813 ], "sequon_annotation_sites": [ { "start_pos": 441, "end_pos": 443 }, { "start_pos": 593, "end_pos": 595 }, { "start_pos": 808, "end_pos": 810 }, { "start_pos": 811, "end_pos": 813 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A7Z052-1", "uniprot_ac": "A7Z052", "uniprot_id": "WDR6_BOVIN", "mass": { "chemical_mass": 122056.0, "monoisotopic_mass": 122056.0 }, "refseq": { "ac": "NP_001099093", "name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099093" }, "gene_names": [ { "name": "WDR6", "type": "recommended", "evidence": [ { "id": "A7Z052", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z052" } ] }, { "name": "WDR6", "type": "synonym", "evidence": [ { "id": "NP_001099093", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099093" } ] } ], "protein_names": [ { "name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "type": "recommended", "evidence": [ { "id": "A7Z052", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z052/entry#names_and_taxonomy" } ] }, { "name": "WD repeat domain 6 protein", "type": "synonym", "evidence": [ { "id": "NP_001099093", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099093" } ] }, { "name": "WD repeat protein 6", "type": "synonym", "evidence": [ { "id": "NP_001099093", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099093" } ] }, { "name": "WD repeat-containing protein 6", "type": "synonym", "evidence": [ { "id": "NP_001099093", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099093" }, { "id": "A7Z052", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z052/entry#names_and_taxonomy" } ] }, { "name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "type": "synonym", "evidence": [ { "id": "NP_001099093", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099093" } ] } ], "function": [ { "annotation": "Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs (By similarity). Required for the correct positioning of the substrate tRNA for methylation (By similarity). Required to suppress amino acid starvation-induced autophagy (By similarity). Enhances the STK11/LKB1-induced cell growth suppression activity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A7Z052", "url": "https://www.uniprot.org/uniprotkb/A7Z052#function" }, { "database": "UniProtKB", "id": "Q9NNW5", "url": "https://www.uniprot.org/uniprotkb/Q9NNW5#function" }, { "database": "UniProtKB", "id": "A0A452DIX7", "url": "https://www.uniprot.org/uniprotkb/A0A452DIX7#function" }, { "database": "UniProtKB", "id": "ARBA00045751", "url": "https://www.uniprot.org/uniprotkb/ARBA00045751#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7Z052", "url": "https://www.uniprot.org/uniprotkb/A7Z052" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR6", "url": "https://www.uniprot.org/uniprotkb/A7Z052", "locus": { "chromosome": "22", "start_pos": 50975112, "end_pos": 50983856, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018910", "url": "https://www.ensembl.org/id/ENSBTAG00000018910" } ] } } ], "crossref": [ { "id": "A7Z052", "url": "https://alphafold.ebi.ac.uk/entry/A7Z052", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018910", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018910", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "526884", "url": "https://www.ncbi.nlm.nih.gov/gene/526884", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051973", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051973", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526884", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526884", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IIVWSCF", "url": "https://omabrowser.org/oma/group/IIVWSCF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DIX7", "url": "https://www.orthodb.org/?gene=A0A452DIX7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A7Z052", "url": "https://www.orthodb.org/?gene=A7Z052", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14344", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14344", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14344:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14344:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9013420", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013420", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013424", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013424", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9696264", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696264", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9696270", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696270", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9696273", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696273", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001099093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099093", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DIX7", "url": "https://www.uniprot.org/uniprotkb/A0A452DIX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIX7-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIX7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7Z052", "url": "https://www.uniprot.org/uniprotkb/A7Z052", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7Z052-1", "url": "https://www.uniprot.org/uniprotkb/A7Z052-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDAHEDYVWPRATSELILLPVTGLECVGERLLAGEGPDVLVYTLDFGGHLRMMKRVQNLLGHYLIHGFRVRPEPNGDLDSEVMVAAFGSKGLRIVKISWGQGRFRELWRSGLWNMSDWIWDARWLEGNIALALGHNSVVLYDPVVGCSLQDVPCTDRCTLSSACLIGDTWKELTVVAGAVSNQLLVWYPAAALTDDKPVVPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCVCLVWSHEGEILQAFRGHQGRGIRALAAHERQAWVITGGDDSGIRLWHLVGRGHPGSGVFALSFKSHSRPGVLKAVTLAGSWRVLAVTDAGALYLYDLEVKCWEQLLEDKRFQSYCLLEAAPGPEGFGLCALANGEGRVKVVPINTPTAAVDLTLFPGKVHSLSWALRGYEELLLLASGPGGVVACLEISAAPSGKAIFVKERCRYLLPPSKQRWHTCSAFLPPGDFLVCGDRRGSVLLYPSRPDLLKDLGVVSKVGAITSAPGAGSGEGEPSLAEWGPMSTLPSLHGKQGVTSVTCHGGYVYTTGRDGSYYQLFVRGGQLQPVLRQKPCRGMNWVAGVRMVADGNMVILGFHANEFVVWSPRSHEKLHIINCGGGHRSWAFSDTEAAMAFAYLKDGDVMLYRALGGCTRPHVILRESLHGREITCVKRVGSITLGPESGVPSFLQPDHLEPGEPVEPGSEGPGLIDIVITCSEDTTVCVLALPTATGSAHALTAVCNHISSVRAVAVWGVGTPGGPQDPQPGLTAHVVSAGGRAEMHCFTIMVTPDPSPPSRLACHVMHLSSHRLDEYWDRQRHRHRMIKVDPETRYMSLAVCELDRPGLGPLVAAACSDGAVRLFLLQDSGRRLQLLAETSHHKRCVLKVHAFTHEAPNRRRRLFLCSAATDGSLAFWDLTTMLDQDSPALEAAADLGLPFQLGSPCLTVQAHSCGVNSLHTLPTREGHLVASGSEDGSLHVFVLAVEMPELEEAVGGAELLPQLQVLEEYSVPCAHAAHVTGLKILSRSLMVSASIDQRLTFWRLGHGEPTFMNSTVYHVADVADMDCWPVSPEFGHRCALGGQGLEVYNWYD", "length": 1124, "header": "sp|A7Z052-1|WDR6_BOVIN Isoform 1 of tRNA (34-2'-O)-methyltransferase regulator WDR6 OS=Bos taurus OX=9913 GN=WDR6 PE=2 SV=1 CANONICAL=A7Z052-1" }, "isoforms": [ { "isoform_ac": "A0A452DIX7-1", "url": "https://www.uniprot.org/uniprotkb/A7Z052/entry#A0A452DIX7-1", "sequence": { "sequence": "MGRRAVVIGPRRRPPLPLLPVATGAVELQRSSTREGSSRESSAPFLAVAAAAARGTAMDAHEDYVWPRATSELILLPVTGLECVGERLLAGEGPDVLVYTLDFGGHLRMMKRVQNLLGHYLIHGFRVRPEPNGDLDSEVMVAAFGSKGLRIVKISWGQGRFRELWRSGLWNMSDWIWDARWLEGNIALALGHNSVVLYDPVVGCSLQDVPCTDRCTLSSACLIGDTWKELTVVAGAVSNQLLVWYPAAALTDDKPVVPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCVCLVWSHEGEILQAFRGHQGRGIRALAAHERQAWVITGGDDSGIRLWHLVGRGHPGSGVFALSFKSHSRPGVLKAVTLAGSWRVLAVTDAGALYLYDLEVKCWEQLLEDKRFQSYCLLEAAPGPEGFGLCALANGEGRVKVVPINTPTAAVDLTLFPGKVHSLSWALRGYEELLLLASGPGGVVACLEISAAPSGKAIFVKERCRYLLPPSKQRWHTCSAFLPPGDFLVCGDRRGSVLLYPSRPDLLKDLGVVSKVGAITSAPGAGSGEGEPSLAEWGPMSTLPSLHGKQGVTSVTCHGGYVYTTGRDGSYYQLFVRGGQLQPVLRQKPCRGMNWVAGVRMVADGNMVILGFHANEFVVWSPRSHEKLHIINCGGGHRSWAFSDTEAAMAFAYLKDGDVMLYRALGGCTRPHVILRESLHGREITCVKRVGSITLGPESGVPSFLQPDHLEPGEPVEPGSEGPGLIDIVITCSEDTTVCVLALPTATGSAHALTAVCNHISSVRAVAVWGVGTPGGPQDPQPGLTAHVVSAGGRAEMHCFTIMVTPDPSPPSRLACHVMHLSSHRLDEYWDRQRHRHRMIKVDPETRYMSLAVCELDRPGLGPLVAAACSDGAVRLFLLQDSGRRLQLLAETSHHKRCVLKVHAFTHEAPNRRRRLFLCSAATDGSLAFWDLTTMLDQDSPALEAAADLGLPFQLGSPCLTVQAHSCGVNSLHTLPTREGHLVASGSEDGSLHVFVLAVEMPELEEAVGGAELLPQLQVLEEYSVPCAHAAHVTGLKILSRSLMVSASIDQRLTFWRLGHGEPTFMNSTVYHVADVADMDCWPVSPEFGHRCALGGQGLEVYNWYD", "length": 1181, "header": "tr|A0A452DIX7-1|WDR6_BOVIN Computationally mapped isoform of tRNA (34-2'-O)-methyltransferase regulator WDR6 OS=Bos taurus OX=9913 GN=WDR6 PE=2 SV=1 CANONICAL=A7Z052-1" }, "locus": { "chromosome": "22", "start_pos": 50983657, "end_pos": 50975785, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025167.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025167.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025167.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025167.6" } ] } }, { "isoform_ac": "A7Z052-1", "url": "https://www.uniprot.org/uniprotkb/A7Z052/entry#A7Z052-1", "sequence": { "sequence": "MDAHEDYVWPRATSELILLPVTGLECVGERLLAGEGPDVLVYTLDFGGHLRMMKRVQNLLGHYLIHGFRVRPEPNGDLDSEVMVAAFGSKGLRIVKISWGQGRFRELWRSGLWNMSDWIWDARWLEGNIALALGHNSVVLYDPVVGCSLQDVPCTDRCTLSSACLIGDTWKELTVVAGAVSNQLLVWYPAAALTDDKPVVPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCVCLVWSHEGEILQAFRGHQGRGIRALAAHERQAWVITGGDDSGIRLWHLVGRGHPGSGVFALSFKSHSRPGVLKAVTLAGSWRVLAVTDAGALYLYDLEVKCWEQLLEDKRFQSYCLLEAAPGPEGFGLCALANGEGRVKVVPINTPTAAVDLTLFPGKVHSLSWALRGYEELLLLASGPGGVVACLEISAAPSGKAIFVKERCRYLLPPSKQRWHTCSAFLPPGDFLVCGDRRGSVLLYPSRPDLLKDLGVVSKVGAITSAPGAGSGEGEPSLAEWGPMSTLPSLHGKQGVTSVTCHGGYVYTTGRDGSYYQLFVRGGQLQPVLRQKPCRGMNWVAGVRMVADGNMVILGFHANEFVVWSPRSHEKLHIINCGGGHRSWAFSDTEAAMAFAYLKDGDVMLYRALGGCTRPHVILRESLHGREITCVKRVGSITLGPESGVPSFLQPDHLEPGEPVEPGSEGPGLIDIVITCSEDTTVCVLALPTATGSAHALTAVCNHISSVRAVAVWGVGTPGGPQDPQPGLTAHVVSAGGRAEMHCFTIMVTPDPSPPSRLACHVMHLSSHRLDEYWDRQRHRHRMIKVDPETRYMSLAVCELDRPGLGPLVAAACSDGAVRLFLLQDSGRRLQLLAETSHHKRCVLKVHAFTHEAPNRRRRLFLCSAATDGSLAFWDLTTMLDQDSPALEAAADLGLPFQLGSPCLTVQAHSCGVNSLHTLPTREGHLVASGSEDGSLHVFVLAVEMPELEEAVGGAELLPQLQVLEEYSVPCAHAAHVTGLKILSRSLMVSASIDQRLTFWRLGHGEPTFMNSTVYHVADVADMDCWPVSPEFGHRCALGGQGLEVYNWYD", "length": 1124, "header": "sp|A7Z052-1|WDR6_BOVIN Isoform 1 of tRNA (34-2'-O)-methyltransferase regulator WDR6 OS=Bos taurus OX=9913 GN=WDR6 PE=2 SV=1 CANONICAL=A7Z052-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:526884", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526884", "resource": "KEGG Pathway" }, { "id": "R-BTA-9013420", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013420", "resource": "Reactome", "description": "RHOU GTPase cycle" }, { "id": "R-BTA-9013424", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013424", "resource": "Reactome", "description": "RHOV GTPase cycle" }, { "id": "R-BTA-9696264", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696264", "resource": "Reactome", "description": "RND3 GTPase cycle" }, { "id": "R-BTA-9696270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696270", "resource": "Reactome", "description": "RND2 GTPase cycle" }, { "id": "R-BTA-9696273", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696273", "resource": "Reactome", "description": "RND1 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BKB6-1", "protein_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "gene_name": "P4HTM", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDAHEDYVWPRATSELILLPVTGLECVGERLLAGEGPDVLVYTLDFGGHLRMMKRVQNLLGHYLIHGFRVRPEPNGDLDSEAMVAVFGSKGLRIVKISWGQGRFRELWRSGLWNLSDWIWDARWLEGNMALALGHNSVVLYDPVVGCILQDVPCTDRCTLSSACLIGDTWKELTIVAGAVSNQLLVWYPAAALIDNKPVAPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCVCLVWSHEGEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHLVGRGHPGSGVSALCFKSHSRPGALKAVTLAGSWRVLAVTDTGALYLYDLEVKCWEQLLEDKRFQSYCLLEAAPGPEGFGLCAMANGEGRVKVVPINTPTAAVDLTLFQGKVHSLSWALRGYEELLLLASGPGGVVACLEISAAPSGKAIFVKERCRYLLPPSKQRWHTCSAFLPPGDFLVCGDRRGSVLLFPSRPDLLKDLGVGGKAGVGAGALGAGGNNEGGENALAEWGPVSSLPSLHGKQGVTSVTCHGGYVYTTGRDGAYYQLFVRGGQLQPVLRQKSCRGMNWVAGLRMVTDGSMVILGFHANEFVVWSPRSHEKLHIINCGGGHRSWAFSDTESAMAFAYLKDGDVMLYRALGGCTRPHVILRESLHGREITCVKRVGTITLGPEFGVPSFIQPDYLEPGSEGPGLIDIVITCSEDTTVCVLALPTATGSAHALTAVCNHISSVRAVAVWGTGTPGGPQDPQPGLTAHVVSAGGRAEMHCFTLMVTPDPSTPSHLACHVMHLSSHRLDEYWDRQRNRHRMIKVDPETRYMSLAVCEFDRPGLGPLVAAACSDGAVRLFLLQDSGQRLQLLAETFHHKRCVLKVHSFTHEAPNQRRRLFLCSAATDGSLAFWDLTTVLDHGSTALEPPVEPGLPYRLGTPCLTLQAHSCGVNSLHTLPTPAGHLVASGSEDGSLHVFVLAVEVPELEEAVGGAEQLPQLQVLEEYSVPCAHAAHVTGLKILSPSLMVSASIDQRLTFWRLGHGEPTFMNSTVYHVPDVADMDCWPVSPEFGHRCALGGQGLEVYNWYD", "length": 1120 }, "evidence": [ { "id": "A7Z052", "url": "https://omabrowser.org/oma/group/A7Z052/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M2BEZ5-1", "protein_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "gene_name": "wdr6", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKSTACCADCEMASPVESAVVKSAVLVAPITALEFLGEDFLLTGEGPILSVYSLQASPKKCASINVLQNYRIHGIRPYKKHQSGGIPFSGASSASDNSYKGDIIVFGGKGVRLVSFESEGQCLKLIGPLLELQDWVLDIHCFKRQPHSLLGISLAHNAIMLLEAESGNIISFYSCVETCLLYSALMVGPNWDSVVLVGGTVFNQLVLWRPAGTKLSGQSQVERRLLGHSGVIFSLCYLQESGWLASASDDRSVRLWSVGTLGGDAGCGKESPTCLRVLYGHQARVFCVKLTPSRLFSAGEDGACLLWEWGGEGKVGCAFRGHKSGGVRALAVSEGSISCRAGWVATGGADGGVRLWRVAEGKKISEETQEETQLDLGFRGHGCPKVVRLVGEGESNAILVCTDQGEVCLSQGDIWDVIWQGGSEFQSYCVMEVASIQVQNSDCIVQVCAVGNLNGGVQVFLVGQPGVGVFLRAGEGKVHSVLWVKGLFGESGNVCLLASGSEGLVYRWTINVTEDKSGLHIKEEALLPFLLPPCAKRWLTAAVTLSQRNGFCLCGDRRGSLLLYMERENNDRINEGEESRIDSQDQETENRQTELVSSLSPISTLYGVHGKQGVTSVCEYQDLCYSTGRDGSVRILTVEESTLKVRRVHRACKGMDWLEMVLFLGSDGPERMLNKTIVKRTNDTGRESIAEARFVMVGFHSVHFVIWDPHRQEKLLSVTCGGGHRSWAFKRPISTHIDTQTQALRQGTLVFIKQGAVMASRSLMSTDTSVNGHTLKEGLHGRGISCVCHLGSLSGDLSELWEVFVTGGEDTTVGVLAVCPQSGIVKVLAVLTDHISIVRALAAIRRGDMNERERNNGMETSVLSSLVFSAGGRAQLQCYRLLIHLDEQQSQPICQVTQIAGHRLDEQWERKRNRHKTVKMDPETRYMSIAVVQNESEGVLLALGCSDGAVRLFSVNESSRSVDVLWECFYHQRCVLSVATCKLEDSQGRKLLLLFSATTDGCISVWDLTAVLNSKASVSWQGPSVPFFSIPVHQSGVNTLALSPRTEKGQTEDNVISLASGGDDGQLSLLRIKIDQAEQENGVASLQLLSHWSIPLAHSSPLTGLCLLSPALLASTSPDQRMCLWSVESDGLRPLQVRFSHIADAAGLWAWRSEGQEGGAWIVVCGQGLQLFQLTEKEIDEAENGRAEGEERKKVMFSHQCSRT", "length": 1204 }, "evidence": [ { "id": "A7Z052", "url": "https://omabrowser.org/oma/group/A7Z052/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5XFW6-1", "protein_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "gene_name": "Wdr6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDAFGDYVWPRATSELILLPVTGLECVGDRLLAGEGPDLLVYNLDFGGHLRMVKRVQNLLGHYLIHGFRVQPEPKGDLDSEAMIAVFGSKGLRVVKISWGQSHLRELWRSGLWNMSDWIWDARWLEGNVALALGHNSVVLYDPVIGCMLQDVPCTDRCTLSSACLIGDTWKELTIVAGAVSNELLVWYPATALPDNKPVAPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCVCLVWSHEGEILQAFRGHQGRGIRAIAAHERQTWVITGGDDSGIRLWHLVGRGYPGLGVSSLSFKSPSRPGALKAVTLAGSWRVLAVTDVGGLYLYDLEVKCWEQLLEDNRFQSYCLLEAAPGPEGFGLCALANGEGLVKVVPINTPTAAVDQNLFQGKVHSLSWALRGYEELLLLASGPGGVVACLEISAAPTGKAIFVKERCRYLLPPSKQRWHTCSAFLPPGDFLVCGDRRGSVLLFPARPCLFKKPGVGPKAITAAEAPQAGSSSGGSESVVTGLGPVSSLHSLHGKQGVTSVTCHGGYVYSTGRDGSYYQLFVHGGRLQPVLRQKACRGMNWIAGLRMAPDGSMVVLGFHANEFVVWSPRSHEKLHIVNCGGGHRSWAFSDTEAAMAFAYLKDGDVMLYRALGGCIRPNVILREGLHGREITCVKRVGTVTLGPEFEVPNLEHPDSLEPGSEGPGLIDIVITGSEDTTVCVLALPTTTGAAHALTAVCNHISSVRALAVWGVGTPGGPQDSHPGLTAQVVSAGGRAEMHCFSLMITPDASTPSRLACHIMHLSSHRLDEYWDRQRNRHRMIKVDPETRYMSLAICELDSDRPGLGPGPLVAAACSDGAVRLFLLQDSGRILHLLAETFHHKRCVLKVHSFTHEAPNQRRRLILCSAATDGSIAFWDLTTAMDRGSTTLEPPAHPGLPYQMGTPCLTVQAHSCGVNSLHTLPTPEGHHLVASGSEDGSLHVFTLAVKMPELEEADGEAELVPQLCVLDEYSVPCAHAAHVTGIKILSPKLMVSASIDQRLTFWRLGNGEPTFMNSTVYHVPDVADMDCWPVNPEFGHRCALAGQGLEVYNWYD", "length": 1125 }, "evidence": [ { "id": "A7Z052", "url": "https://omabrowser.org/oma/group/A7Z052/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86B53-1", "protein_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVLISDAFGLEISPNGILVGHGDQAVLYSSEPKVELPVQLREGKVRGFAWSSLRKSQRLLLLYSENEYSLIRCTTSSENDLFQLVYEGETRDWINAALFLEDENESEDRKRFVLHTSHSALLYMEYDLTSNADCTVLELARCTDSSILYYTKLHGSSFNKLAIISGNAFGELLVWQTQFPTESDPKSVMKTYPLLLRIEAHNGVIHSIEFDLQSQLLVTTSDDRSVKFWNIQKSGDWTTAEIKPMFSCYGHSSRVMCVVILKIDDRTFVASGGEDSYVCIWSSSGELILKRRQQFGAPIWRLGFSQDAEILYSTSSTGNLVGQNLKEVLNRPKIESTILSSLGDANEFVRNLKFVNNEIIVGLSSLNRLYYTRISPDSSHENKWLMVNDFPSYKRTVLEVFDDIIATCGHRRITLHRYNTNTNDFEQLFDGIRMKGTIRSFQFLSRDRYLVSDNLGYCLLLQTHQLHIESHIALFNNREPWITAALLISEQYLLLGNREGHVMLYCRSSASDDFQLKDSIRYLHGKMGSNFFKLLSLNADNAHVMSGGHEAFLKYLSVRFSDSTLRVSQREGIPLAWVEASPSDDLILGFNDNHIVAWSRRNDILLQLACGGGHRCWDFRLSDGDSQLSIAYVKQKRVYFYRNSLYNAVDNRLKDIEPNNWHVRNCNTLRLITPRNQSDPFILSAGDDNIIKVTQVTNDSLSQRAEMHSHISTVRSLQAIPYKSNGGDSSTWLVFSVGGRSQLCISQLSIDASNKCWISEISSHTLHNVAASKTSTIEARLMAIDVVQHSDGDLFSIYVAGGDGNISHYIWELETPNQLDLKHFVDIQRCPLGIQWIASKGMLLVSTTNGEVYGFDRTLETTYFQLQLHVTGINTIDIYVDRHLLHILSGGDDESIKYTVLNLNNNNVEQKIEYLGLHNAQVNALAIHCPTKSVAASELFAYTCSIDRQIYRIDLSTHKYKRVGYTCIADVKGMLLDEHQRMYFYGCGLQTMSISNIL", "length": 998 }, "evidence": [ { "id": "A7Z052", "url": "https://omabrowser.org/oma/group/A7Z052/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q99ME2-1", "protein_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "gene_name": "Wdr6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDAFGDYVWPRATSELILLPVTGLECVGDRLLAGEGPDLLVYNLDLGGHLRMVKRVQNLLGHFLIHGFRVRPEPKGDLDSEAMIAVFGSKGLKVVKVSWGQSHLRELWRSGLWNMSDWIWDVRWIEGNVAVALGHNSVVLYDPVIGCMLQDVPCTDRCTLSSACLVGDTWKELTIVAGAVSNELLIWYPATALTDNKPVAPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRLWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCVCLVWSHEGEILQAFRGHRGRGIRAIATHERQAWVVTGGDDSGIRLWHLAGRGYPGLGVSSLSFKSPSRPGALKAVTLAGSWRVLAVTDVGSLYLYDLEVKSWEQLLEDNRFRSYCLLEAAPGPEGFGLCALANGEGLVKVVPINTPTAAVEQKLFQGKVHSLSWALRGYEELLLLASGPGGVIACLEISAAPTGKAIFVKERCRYLLPPSKQRWHTCSAFLPPGDFLVCGDRRGSVMLFPVRPCLFKKPGAGSKAITAAEAPGAGSGSGGSESVPTGIGPVSTLHSLHGKQGVTSVTCHGGYLYSTGRDSSYFQLFVHGGHLQPVLRQKACRGMNWVAGLRMVPDGSMVILGFHANEFVVWSPRSHEKLHIVNCGGGHRSWAFSDTEAAMAFTYLKDGEVMLYRALGGCIRPNVILREGLHGREITCVKRVGTVTLGPEFEVPNLEHPDSLEPGSEGPGLIDIVITGSEDTTVCVLALPTTTGSAHALTSVCNHISSVRALAVWAVGTPGGPQDTRPGLTAQVVSAGGRAEIHCFSVMVTPDASTPSRLACHVMHLSSHRLDEYWDRQRNKHKMIKVDPETRYMSLAICELDNDRPGLGPGPLVAAACSDGAVRLFLLQDSGRILHLLAESFHHKRCVLKVHSFTHEAPNQRRRLILCSAATDGSLAFWDLTTAMDKGSTTLELPAHPGLPYQMGTPSMTVQAHSCGVNSLHTLPTPEGHHLVASGSEDGSLHVFTLAVKMPEPEEADGEAELVPQLCVLEEYSVPCAHAAHVTGVKILSPKLMVSASIDQRLTFWRLGQGEPTFMNSTVYHVPDVADMDCWPVSPEFGHRCALAGQGLEVYNWYD", "length": 1125 }, "evidence": [ { "id": "A7Z052", "url": "https://omabrowser.org/oma/group/A7Z052/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NNW5-1", "protein_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "gene_name": "WDR6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDALEDYVWPRATSELILLPVTGLECVGDRLLAGEGPDVLVYSLDFGGHLRMIKRVQNLLGHYLIHGFRVRPEPNGDLDLEAMVAVFGSKGLRVVKISWGQGHFWELWRSGLWNMSDWIWDARWLEGNIALALGHNSVVLYDPVVGCILQEVPCTDRCTLSSACLIGDAWKELTIVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCVCLVWSHEGEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHLVGRGYRGLGVSALCFKSRSRPGTLKAVTLAGSWRLLAVTDTGALYLYDVEVKCWEQLLEDKHFQSYCLLEAAPGPEGFGLCAMANGEGRVKVVPINTPTAAVDQTLFPGKVHSLSWALRGYEELLLLASGPGGVVACLEISAAPSGKAIFVKERCRYLLPPSKQRWHTCSAFLPPGDFLVCGDRRGSVLLFPSRPGLLKDPGVGGKARAGAGAPVVGSGSSGGGNAFTGLGPVSTLPSLHGKQGVTSVTCHGGYVYTTGRDGAYYQLFVRDGQLQPVLRQKSCRGMNWLAGLRIVPDGSMVILGFHANEFVVWNPRSHEKLHIVNCGGGHRSWAFSDTEAAMAFAYLKDGDVMLYRALGGCTRPHVILREGLHGREITCVKRVGTITLGPEYGVPSFMQPDDLEPGSEGPDLTDIVITCSEDTTVCVLALPTTTGSAHALTAVCNHISSVRAVAVWGIGTPGGPQDPQPGLTAHVVSAGGRAEMHCFSIMVTPDPSTPSRLACHVMHLSSHRLDEYWDRQRNRHRMVKVDPETRYMSLAVCELDQPGLGPLVAAACSDGAVRLFLLQDSGRILQLLAETFHHKRCVLKVHSFTHEAPNQRRRLLLCSAATDGSLAFWDLTTMLDHDSTVLEPPVDPGLPYRLGTPSLTLQAHSCGINSLHTLPTREGHHLVASGSEDGSLHVFVLAVEMLQLEEAVGEAGLVPQLRVLEEYSVPCAHAAHVTGLKILSPSIMVSASIDQRLTFWRLGHGEPTFMNSTVFHVPDVADMDCWPVSPEFGHRCALGGQGLEVYNWYD", "length": 1121 }, "evidence": [ { "id": "A7Z052", "url": "https://omabrowser.org/oma/group/A7Z052/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A7Z052", "url": "https://www.uniprot.org/uniprotkb/A7Z052" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A7Z052", "url": "https://www.uniprot.org/uniprotkb/A7Z052" } ], "pmid": "" }, { "name": "COP9 signalosome", "id": "GO:0008180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008180", "evidence": [ { "database": "UniProtKB", "id": "A7Z052", "url": "https://www.uniprot.org/uniprotkb/A7Z052" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "tRNA binding", "id": "GO:0000049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", "evidence": [ { "database": "UniProtKB", "id": "A7Z052", "url": "https://www.uniprot.org/uniprotkb/A7Z052" } ], "pmid": "" }, { "name": "enzyme regulator activity", "id": "GO:0030234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030234", "evidence": [ { "database": "UniProtKB", "id": "A7Z052", "url": "https://www.uniprot.org/uniprotkb/A7Z052" } ], "pmid": "" }, { "name": "enzyme-substrate adaptor activity", "id": "GO:0140767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140767", "evidence": [ { "database": "UniProtKB", "id": "A7Z052", "url": "https://www.uniprot.org/uniprotkb/A7Z052" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "tRNA methylation", "id": "GO:0030488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030488", "evidence": [ { "database": "UniProtKB", "id": "A7Z052", "url": "https://www.uniprot.org/uniprotkb/A7Z052" } ], "pmid": "" }, { "name": "wobble position ribose methylation", "id": "GO:0002130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002130", "evidence": [ { "database": "UniProtKB", "id": "A7Z052", "url": "https://www.uniprot.org/uniprotkb/A7Z052" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "A7Z052", "url": "https://www.uniprot.org/uniprotkb/A7Z052" } ], "pmid": "" }, { "name": "negative regulation of autophagy", "id": "GO:0010507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010507", "evidence": [ { "database": "UniProtKB", "id": "A7Z052", "url": "https://www.uniprot.org/uniprotkb/A7Z052" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1085, "end_pos": 1087, "annotation": "n_glycosylation_sequon" }, { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7Z052-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1124, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7Z052-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7Z052" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1085, "end_pos": 1087 }, { "start_pos": 114, "end_pos": 116 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BBC6-1", "uniprot_ac": "E1BBC6", "uniprot_id": "E1BBC6_BOVIN", "mass": { "chemical_mass": 80394.0, "monoisotopic_mass": 80394.0 }, "refseq": { "ac": "XP_059743072", "name": "prolyl 3-hydroxylase 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743072" }, "gene_names": [ { "name": "P3H3", "type": "recommended", "evidence": [ { "id": "E1BBC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBC6" } ] }, { "name": "P3H3", "type": "synonym", "evidence": [ { "id": "XP_059743072", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743072" } ] } ], "protein_names": [ { "name": "procollagen-proline 3-dioxygenase", "type": "recommended", "evidence": [ { "id": "E1BBC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBC6/entry#names_and_taxonomy" } ] }, { "name": "1.14.11.7", "type": "synonym", "evidence": [ { "id": "E1BBC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBC6/entry#names_and_taxonomy" } ] }, { "name": "prolyl 3-hydroxylase 3", "type": "synonym", "evidence": [ { "id": "XP_059743072", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743072" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBC6", "url": "https://www.uniprot.org/uniprotkb/E1BBC6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "P3H3", "url": "https://www.uniprot.org/uniprotkb/E1BBC6", "locus": { "chromosome": "5", "start_pos": 103610181, "end_pos": 103623649, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003598", "url": "https://www.ensembl.org/id/ENSBTAG00000003598" } ] } } ], "crossref": [ { "id": "E1BBC6", "url": "https://alphafold.ebi.ac.uk/entry/E1BBC6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003598", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003598", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "132345345", "url": "https://www.ncbi.nlm.nih.gov/gene/132345345", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006620", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006620", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039575", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039575", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044862", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044862", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056585", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056585", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:132345345", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:132345345", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KQCWREP", "url": "https://omabrowser.org/oma/group/KQCWREP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR14049", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14049", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14049:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14049:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13640", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13640", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23557", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23557", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1650814", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1650814", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059743072", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743072", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "22872", "url": "https://www.rhea-db.org/rhea/22872", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S009", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S009", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S009-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S009-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1J2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1J2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1J2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1J2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBC6", "url": "https://www.uniprot.org/uniprotkb/E1BBC6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBC6-1", "url": "https://www.uniprot.org/uniprotkb/E1BBC6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRPLRWLLLLLLLPPPGSPEPPGLAPPSPGAPPQAPDLLYADGLRAYAAGAWAPAVALLREALRSRAALGRVRRDCGAHCAAEPGVSLPAAPGPDSGPGAWEPLLLRAALRRAECLTQCGARRLGPGGAARLRVGSAVRDAFRRREPYNYLQRAYYQLKKLDLAAAAAHTFFVANPAHLQMREDMAKYRRMSGVRPQSFRDLETPPYWAAFDTGLEHLGRQEAGLALPWLEEALQESLAQVESCRAGCEGPEEQEREAEEEEGTGSQGGLYEAIAGHWTRVLQCRQRCVGDVATRPGRSLPVPDFLPTQLRRLHEAHAQVGNLSQAMENVLSFLLFYPEDEAAKTALDRYQAQLGEPRPGLGPREDIQRFVLRSLGEKRQLYYAVEHLGASFKDPDPWTPAAFIPEALREKLREDQEKRPWDDEPPQPKPLTHWKDVLLMEGVTLTQDARQLNGSERAVLDGLLTPAECGVLLQLAKDAAEAGARSGYRGRRSPHTPHERFEGLTVLKAAQLARAGAVGSQGAQLLLEVSERVRSLTQAYFSPDRPLHLSFTHLVCRSAIEGEQAQRMDLSHPVHADNCVLDPDTGECWREPPAYTYRDYSGLLYLNDDFQGGDLFFTEPNALTVTAQVRPRCGRLVAFSSGVENPHGVWAVTRGRRCALALWHTWAPEHREQEWMEAKELLRGPEKDEGEDVASRDPGPEPPSRRLPRLQDKAGKPPRIREEL", "length": 725, "header": "tr|E1BBC6-1|E1BBC6_BOVIN Isoform 1 of procollagen-proline 3-dioxygenase OS=Bos taurus OX=9913 GN=P3H3 PE=3 SV=3 CANONICAL=E1BBC6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S009-1", "url": "https://www.uniprot.org/uniprotkb/E1BBC6/entry#A0AAA9S009-1", "sequence": { "sequence": "MLRPLRWLLLLLLLPPPGSPEPPGLAPPSPGAPPQAPDLLYADGLRAYAAGAWAPAVALLREALRSRAALGRVRRDCGAHCAAEPGVSLPAAPGPDSGPGAWEPLLLRAALRRAECLTQCGARRLGPGGAARLRVGSAVRDAFRRREPYNYLQRAYYQAAFDTGLEHLGRQEAGLALPWLEEALQESLAQVESCRAGCEGPEEQEREAEEEEGTGSQGGLYEAIAGHWTRVLQCRQRCVGDVATRPGRSLPVPDFLPTQLRRLHEAHAQVGNLSQAMENVLSFLLFYPEDEAAKTALDRYQAQLGEPRPGLGPREDIQRFVLRSLGEKRQLYYAVEHLGASFKDPDPWTPAAFIPEALREKLREDQEKRPWDDEPPQPKPLTHWKDVLLMEGVTLTQDARQLNGSERAVLDGLLTPAECGVLLQLAKDAAEAGARSGYRGRRSPHTPHERFEGLTVLKAAQLARAGAVGSQGAQLLLEVSERVRSLTQAYFSPDRPLHLSFTHLVCRSAIEGEQAQRMDLSHPVHADNCVLDPDTGECWREPPAYTYRDYSGLLYLNDDFQGGDLFFTEPNALTVTAQVRPRCGRLVAFSSGVENPHGVWAVTRGRRCALALWHTWAPEHREQEWMEAKELLRGPEKDEGEDVASRDPGPEPPSRRLPRLQDKAGKPPRIREEL", "length": 674, "header": "tr|A0AAA9S009-1|E1BBC6_BOVIN Computationally mapped isoform of procollagen-proline 3-dioxygenase OS=Bos taurus OX=9913 GN=P3H3 PE=3 SV=1 CANONICAL=E1BBC6-1" }, "locus": { "chromosome": "5", "start_pos": 103623450, "end_pos": 103610523, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107827.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107827.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076670.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076670.1" } ] } }, { "isoform_ac": "A0AAA9T1J2-1", "url": "https://www.uniprot.org/uniprotkb/E1BBC6/entry#A0AAA9T1J2-1", "sequence": { "sequence": "MLRPLRWLLLLLLLPPPGSPEPPGLAPPSPGAPPQAPDLLYADGLRAYAAGAWAPAVALLREALRSRAALGRVRRDCGAHCAAEPGVSLPAAPGPDSGPGAWEPLLLRAALRRAECLTQCGARRLGPGGAARLRVGSAVRDAFRRREPYNYLQRAYYQLKKLDLAAAAAHTFFVANPAHLQMREDMAKYRRMSGVRPQSFRDLETPPYWAAFDTGLEHLGRQEAGLALPWLEEALQESLAQVESCRAGCEGPEEQEREAEEEEGTGSQGGLYEAIAGHWTRVLQCRQRCVGDVATRPGRSLPVPDFLPTQLRRLHEAHAQVGNLSQAMENVLSFLLFYPEDEAAKTALDRYQAQLGEPRPGLGPREDIQRFVLRSLGEKRQLYYAVEHLGASFKDPDPWTPAAFIPEALREKLREDQEKRPWDDEPPQPKPLTHWKDVLLMEGVTLTQDARQLNGSERAVLDGLLTPAECGVLLQLAKDAAEAGARSGYRGRRSPHTPHERFEGLTVLKAAQLARAGAVGSQGAQLLLEVSERVRSLTQAYFSPDRPLHLSFTHLVCRSAIEGEQAQRMDLSHPVHADNCVLDPDTGECWREPPAYTYRDYRWAALQGLGGVPGWGLTACLLSSSLSSGLLYLNDDFQGGDLFFTEPNALTVTAQVRPRCGRLVAFSSGVENPHGVWAVTRGRRCALALWHTWAPEHREQEWMEAKELLRGPEKDEGEDVASRDPGPEPPSRRLPRLQDKAGKPPRIREEL", "length": 751, "header": "tr|A0AAA9T1J2-1|E1BBC6_BOVIN Computationally mapped isoform of procollagen-proline 3-dioxygenase OS=Bos taurus OX=9913 GN=P3H3 PE=3 SV=1 CANONICAL=E1BBC6-1" }, "locus": { "chromosome": "5", "start_pos": 103623450, "end_pos": 103610523, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134845.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134845.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089530.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089530.1" } ] } }, { "isoform_ac": "E1BBC6-1", "url": "https://www.uniprot.org/uniprotkb/E1BBC6/entry#E1BBC6-1", "sequence": { "sequence": "MLRPLRWLLLLLLLPPPGSPEPPGLAPPSPGAPPQAPDLLYADGLRAYAAGAWAPAVALLREALRSRAALGRVRRDCGAHCAAEPGVSLPAAPGPDSGPGAWEPLLLRAALRRAECLTQCGARRLGPGGAARLRVGSAVRDAFRRREPYNYLQRAYYQLKKLDLAAAAAHTFFVANPAHLQMREDMAKYRRMSGVRPQSFRDLETPPYWAAFDTGLEHLGRQEAGLALPWLEEALQESLAQVESCRAGCEGPEEQEREAEEEEGTGSQGGLYEAIAGHWTRVLQCRQRCVGDVATRPGRSLPVPDFLPTQLRRLHEAHAQVGNLSQAMENVLSFLLFYPEDEAAKTALDRYQAQLGEPRPGLGPREDIQRFVLRSLGEKRQLYYAVEHLGASFKDPDPWTPAAFIPEALREKLREDQEKRPWDDEPPQPKPLTHWKDVLLMEGVTLTQDARQLNGSERAVLDGLLTPAECGVLLQLAKDAAEAGARSGYRGRRSPHTPHERFEGLTVLKAAQLARAGAVGSQGAQLLLEVSERVRSLTQAYFSPDRPLHLSFTHLVCRSAIEGEQAQRMDLSHPVHADNCVLDPDTGECWREPPAYTYRDYSGLLYLNDDFQGGDLFFTEPNALTVTAQVRPRCGRLVAFSSGVENPHGVWAVTRGRRCALALWHTWAPEHREQEWMEAKELLRGPEKDEGEDVASRDPGPEPPSRRLPRLQDKAGKPPRIREEL", "length": 725, "header": "tr|E1BBC6-1|E1BBC6_BOVIN Isoform 1 of procollagen-proline 3-dioxygenase OS=Bos taurus OX=9913 GN=P3H3 PE=3 SV=3 CANONICAL=E1BBC6-1" }, "locus": { "chromosome": "5", "start_pos": 103623450, "end_pos": 103610523, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037738.6", "url": "https://www.ensembl.org/id/ENSBTAT00000037738.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037562.5", "url": "https://www.ensembl.org/id/ENSBTAP00000037562.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 654, "start_aa": "Thr", "end_pos": 654, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr654", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:132345345", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:132345345", "resource": "KEGG Pathway" }, { "id": "R-BTA-1650814", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1650814", "resource": "Reactome", "description": "Collagen biosynthesis and modifying enzymes" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZW10-1", "protein_name": "procollagen-proline 3-dioxygenase", "gene_name": "P3H3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASLVCLLLLLLLPAATSSVAGRLVPYDLLYADGVRAYFARDWGRAAELLQRALYSYAGLRAARLACRDACLREAAFLGEPPAAGPWEAALFDRVLQRADCLQHCLGSRLGAAPSAHRASLVIQRDFERREPYNYLQVAFFQLKKLDQAVSAAHTFFVANPQHLQMREDIEKYRRMSGVKSDNFRDLEAAPHWEAYEAGMQHYNADEYVQAVDRLEESLREALSALEECRALCEGPLEDEEEEDLQPGLYEAIAAHYIQVLKCRQQCVLEIATKPGWISATEDFIPSHLDLLQFAYDQVGNPALAAECAASYLLFYPTDEPVLEKMKQYRAELGQDTAVTARENIRHYVQRSLMEKKLIYYATEHLGGTFNDPDLWTPDELIPENLKQKYREDQKKQKQETLDMEERGKRGSLPFEGITVTMDSQQMNGTQRVVFDRVLTESECKDLLRLTEAARGTGDGYRARRSPHTPHERFEGLTVLKAMQLAQNGDVDWRDAKLLLQASEKSRKIIESYFTPGKKLHFSFTHLVCRTAVEEEQEGRMDLSHPVHADNCLLDPEGKECWKEPPAYVYRDYSGILYLNDDFRGGSLFFTDIDTVTVTANVHPKCGRLVAFSSGKENPHGVRAVSQGRRCAIALWYTHSAEHAEQERVKAEELMEQRAVEENQPDGEEYHGADRSSRSSPEPLVSGGGTRPTSQKHKSVSERTQHPKKLRARDEF", "length": 716 }, "evidence": [ { "id": "E1BBC6", "url": "https://omabrowser.org/oma/group/E1BBC6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0AA76ENW5-1", "protein_name": "procollagen-proline 3-dioxygenase", "gene_name": "P3h3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLRLLRLLLLLLLPPPGSPEPSEPPGLAQLSPGAPPQAPDLLYADGLRAYSAGAWAPAVALLREALRSREVLGRARQDCGASCAAEPGAALPAQILGAPQPVSGPGAWEPLLLRATLRRAECLTQCAAGRLGPGGAARFRVVSALRDAFRRREPYNYLQRAYYQLKKLDLAASAAHTFFVANPTHLQMREDMAKYRRMSAIRPQSFQDLVTPLYWAAYDTGLELLKQQEAALALPKLEEALQGSLAQMESCRAGCEGPEEHQGAEEEEEKGTQGGLYEAIAGHWIRVLQCRQHCVAETATRPGRSFPVRDFLPSQLRRLHEAYAQVGNVSQAVENVLSVLLFYPEDEAAKRALNQYQTQLGELRPDLGPREDVQRFILRSLGEKRQLYYAMEHLGTSFKDPDSWTPEAFIPKALREKLREDQEKKPWDSEPPQQKPPTYWKDALLLEGVTLTQDAQQLNGSERAVLDGLLTPAECGLLLQLAKDAAEAGARSGYRGRRSPHSPHERFEGLTVLKAAQLARAGTVGRPGAKLLLEVSERVRTLTQAYFSPERPLHLSFTHLVCRSAIEGEQEQRMDLSHPVHADNCFLDPDTGECWREPPAYTYRDYSGLLYLNDDFKGGDLFFTQPNALTVTAQVRPRCGRLVAFSSGGENPHGVWAVTRGRRCALALWHTWAPEHREQEWTEAKELLREEEEEEEENEEEEEILSRDPSPEPPSHKLQRVQDKAGKPLRVREEL", "length": 735 }, "evidence": [ { "id": "E1BBC6", "url": "https://omabrowser.org/oma/group/E1BBC6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SLU9-1", "protein_name": "procollagen-proline 3-dioxygenase", "gene_name": "P3H3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLRLLWLLLLLLLLPPPGSPEPPGLAPLSPGAPPQAPDLLYADGLRAYAAGAWAPAVALLREALRSRVALGRARRDCQERCAAEPGAALPALLAAAPGPGAARGAWEPLLLRAALRRAECLTQCAARRLGPGGAARLRVGSTLRDAFRRREPYNYLQRAYYQLKKLDLAVAAAHTFFVANPTHLQMQEDMAKYRRMPGVRPQSFRDLETPSYWAAYDTGLELLGRQEAGLALPRLEEALQESLAQMESCRAGCEGPEEQQREEEEEGTGSQGGLYEAIAGHWIRVLQCRQRCVGDTATRPGRSFPVPDFLPSQLRRLHEAHAQVGNLSQAVENVQSVLLFYPEDEAAKKALDQYQAQLGEPRPGLGPREDIQRFVLRSLGEKKQLYYAMEHLGASFKDPDPWTPAAFIPEALRQKLREDQEKRPWDHEPPQPKPLTHWKDVLLLEGVTLTQDARQLNGSERAVLDGLLTPAECGVLLQLAKDAAEAGARSGYRGRRSPHTPHERFEGLTVLKAAQLARAGAVGSQGAQLLLEVSERVRTLTQAYFSPERPLHLSFTHLVCRSAIEGEQAQRMDLSHPVHADNCVLDPDTGECWREPPAYTYRDYSGLLYLNDDFQGGDLFFTEPNALTVTAQVRPRCGRLVAFSSGGENPHGVWAVTRGRRCALALWHTWAPEHREQEWTEAKELLQVPEEEGEEMPSRDPAPEPPSRRLQRAQDKAGKPPRVREEL", "length": 727 }, "evidence": [ { "id": "E1BBC6", "url": "https://omabrowser.org/oma/group/E1BBC6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8CG70-1", "protein_name": "Prolyl 3-hydroxylase 3", "gene_name": "P3h3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRLLRLLLLLLLPPPGSPEPPEPPGLAQLSPGSPPQAPDLLYADGLRAYSAGAWAPAVALLREALRSRAALGRARQECGASCAAEPGAALPSQLLGAPHPVSGPGVWEPLLLRATLRRAECLTQCAVRRLGPGGAARLRVGSALRDAFRRREPYNYLQRAYYQLKKLDLAASAAHTFFVANPTHLQMREDMAKYRRMSAIRPQSFRDLVTPLYWAAYDTGLELLEQREAALALPQLEEALQGSLAHMESCRAACEGPEEHQGAEEEGEGSQGGLYEAIAGHWIRVLQCRQHCVADTATRPGRSFPVQDFLLSQLRRLHEAYAQVGNMSQAMENVLSVLLFYPEDEAAKKALNQYQTQLGEPRPDLGPREDIQRFILRSLGEKRQLYYAMEHLGTSFKDPDSWTPEALIPKALRERLREDQEKKPWDHQPPQQKPLAHWKDALLMEGVTLTQDAQQLNGSERAVLDGLLTSAECGVLLQLAKDAAQAGARSGYRGRRSPHSPHERFEGLTVLKAAQLARAGTVGRPGAKLLLEVSERVRTLTQAYFSPERPLHLSFTHLVCRSAIEGEQEQRMDLSHPVHADNCVLDPDTGECWREPPAYTYRDYSGLLYLNDDFKGGDLFFTQPNALTVTAQVRPRCGRLVAFSSGGENPHGVWAVTRGRRCALALWHTWAPEHSEQEWTEAKELLQEEEEEEEEEDILSRDPSPEPPSHKLQRVQEKAGKPRRVRVREEL", "length": 732 }, "evidence": [ { "id": "E1BBC6", "url": "https://omabrowser.org/oma/group/E1BBC6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IVL6-1", "protein_name": "Prolyl 3-hydroxylase 3", "gene_name": "P3H3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLRLLRPLLLLLLLPPPGSPEPPGLTQLSPGAPPQAPDLLYADGLRAYAAGAWAPAVALLREALRSQAALGRVRLDCGASCAADPGAALPAVLLGAPEPDSGPGPTQGSWERQLLRAALRRADCLTQCAARRLGPGGAARLRVGSALRDAFRRREPYNYLQRAYYQLKKLDLAAAAAHTFFVANPMHLQMREDMAKYRRMSGVRPQSFRDLETPPHWAAYDTGLELLGRQEAGLALPRLEEALQGSLAQMESCRADCEGPEEQQGAEEEEDGAASQGGLYEAIAGHWIQVLQCRQRCVGETATRPGRSFPVPDFLPNQLRRLHEAHAQVGNLSQAIENVLSVLLFYPEDEAAKRALNQYQAQLGEPRPGLGPREDIQRFILRSLGEKRQLYYAMEHLGTSFKDPDPWTPAALIPEALREKLREDQEKRPWDHEPVKPKPLTYWKDVLLLEGVTLTQDSRQLNGSERAVLDGLLTPAECGVLLQLAKDAAGAGARSGYRGRRSPHTPHERFEGLTVLKAAQLARAGTVGSQGAKLLLEVSERVRTLTQAYFSPERPLHLSFTHLVCRSAIEGEQEQRMDLSHPVHADNCVLDPDTGECWREPPAYTYRDYSGLLYLNDDFQGGDLFFTEPNALTVTARVRPRCGRLVAFSSGVENPHGVWAVTRGRRCALALWHTWAPEHREQEWIEAKELLQESQEEEEEEEEEMPSKDPSPEPPSRRHQRVQDKTGRAPRVREEL", "length": 736 }, "evidence": [ { "id": "E1BBC6", "url": "https://omabrowser.org/oma/group/E1BBC6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "E1BBC6", "url": "https://www.uniprot.org/uniprotkb/E1BBC6" } ], "pmid": "" }, { "name": "L-ascorbic acid binding", "id": "GO:0031418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031418", "evidence": [ { "database": "UniProtKB", "id": "E1BBC6", "url": "https://www.uniprot.org/uniprotkb/E1BBC6" } ], "pmid": "" }, { "name": "procollagen-proline 3-dioxygenase activity", "id": "GO:0019797", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019797", "evidence": [ { "database": "UniProtKB", "id": "E1BBC6", "url": "https://www.uniprot.org/uniprotkb/E1BBC6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "collagen metabolic process", "id": "GO:0032963", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032963", "evidence": [ { "database": "UniProtKB", "id": "E1BBC6", "url": "https://www.uniprot.org/uniprotkb/E1BBC6" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "E1BBC6", "url": "https://www.uniprot.org/uniprotkb/E1BBC6" } ], "pmid": "" }, { "name": "collagen biosynthetic process", "id": "GO:0032964", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032964", "evidence": [ { "database": "UniProtKB", "id": "E1BBC6", "url": "https://www.uniprot.org/uniprotkb/E1BBC6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "catalytic complex", "id": "GO:1902494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902494", "evidence": [ { "database": "UniProtKB", "id": "E1BBC6", "url": "https://www.uniprot.org/uniprotkb/E1BBC6" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "E1BBC6", "url": "https://www.uniprot.org/uniprotkb/E1BBC6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 323, "end_pos": 325, "annotation": "n_glycosylation_sequon" }, { "start_pos": 454, "end_pos": 456, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "22872", "name": "", "equation": "L-prolyl-[collagen] + 2-oxoglutarate + O2 = trans-3-hydroxy-L-prolyl-[collagen] + succinate + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BBC6-1" ], "evidence": [ { "id": "22872", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22872" } ] }, { "id": "R-BTA-1980233", "name": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum lumen", "input_participant_list": [], "output_participant_list": [ "R-ALL-1650769" ], "enzyme_list": [ "P80311-1", "E1BBC6-1" ], "evidence": [ { "id": "R-BTA-1980233", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1980233" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1650769", "participant_name": "SUCCA [endoplasmic reticulum lumen]", "crossref": [ { "id": "ZINC000000895030", "database": "ZINC", "url": "" }, { "id": "C00042", "database": "COMPOUND", "url": "" }, { "id": "30031", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "E1BBC6", "gene_name": "P3H3", "activity": [ { "ec_number": "1.14.11.7", "activity": "L-prolyl-[collagen] + 2-oxoglutarate + O2 = trans-3-hydroxy-L-prolyl-[collagen] + succinate + CO2.", "evidence": [ { "id": "E1BBC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBC6" } ] }, { "ec_number": "1.14.11.7", "activity": "", "evidence": [ { "id": "E1BBC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBC6" } ] } ] }, { "uniprot_ac": "P80311", "gene_name": "PPIB", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P80311", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80311" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P80311", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80311" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBC6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 725, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBC6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBC6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBC6" }, { "id": "PS51471", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51471" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fe2OG dioxygenase", "eco_id": "ECO_0000259", "start_pos": 553, "end_pos": 667, "start_aa": "Thr", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.14.11.7", "ec_name": "L-prolyl-[collagen] + 2-oxoglutarate + O2 = trans-3-hydroxy-L-prolyl-[collagen] + succinate + CO2.", "evidence": [ { "id": "1.14.11.7", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.7" }, { "id": "1.14.11.7", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.14.11.7" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 654 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 323, "end_pos": 325 }, { "start_pos": 454, "end_pos": 456 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BB38-1", "uniprot_ac": "E1BB38", "uniprot_id": "E1BB38_BOVIN", "mass": { "chemical_mass": 74728.0, "monoisotopic_mass": 74728.0 }, "refseq": { "ac": "NP_001179150", "name": "signal recognition particle subunit SRP72", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179150" }, "gene_names": [ { "name": "SRP72", "type": "recommended", "evidence": [ { "id": "E1BB38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB38" } ] }, { "name": "SRP72", "type": "synonym", "evidence": [ { "id": "NP_001179150", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179150" } ] } ], "protein_names": [ { "name": "Signal recognition particle subunit SRP72", "type": "recommended", "evidence": [ { "id": "E1BB38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB38/entry#names_and_taxonomy" } ] }, { "name": "signal recognition particle subunit SRP72", "type": "synonym", "evidence": [ { "id": "NP_001179150", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179150" } ] } ], "function": [ { "annotation": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER. The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER. Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68. Can bind 7SL RNA with low affinity. The SRP complex possibly participates in the elongation arrest function.", "evidence": [ { "database": "UniProtKB", "id": "E1BB38", "url": "https://www.uniprot.org/uniprotkb/E1BB38#function" }, { "database": "UniProtKB", "id": "ARBA00058587", "url": "https://www.uniprot.org/uniprotkb/ARBA00058587#function" }, { "database": "UniProtKB", "id": "A0AAA9S2A4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2A4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BB38", "url": "https://www.uniprot.org/uniprotkb/E1BB38" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SRP72", "url": "https://www.uniprot.org/uniprotkb/E1BB38", "locus": { "chromosome": "6", "start_pos": 71871800, "end_pos": 71846136, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010593", "url": "https://www.ensembl.org/id/ENSBTAG00000010593" } ] } } ], "crossref": [ { "id": "E1BB38", "url": "https://alphafold.ebi.ac.uk/entry/E1BB38", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010593", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010593", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "509430", "url": "https://www.ncbi.nlm.nih.gov/gene/509430", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013699", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013699", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026270", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026270", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509430", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509430", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NDMKVLA", "url": "https://omabrowser.org/oma/group/NDMKVLA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BB38", "url": "https://www.orthodb.org/?gene=E1BB38", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14094", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14094", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14094:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14094:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08492", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08492", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13181", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13181", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17004", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17004", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179150", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S2A4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2A4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2A4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2A4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLM7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB38", "url": "https://www.uniprot.org/uniprotkb/E1BB38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB38-1", "url": "https://www.uniprot.org/uniprotkb/E1BB38-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVFANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCYNTACALIGQGQLSQAMRILQKAEDLCRRSFSEDSDGTEEDPQAELAIIHGQMAYILQLQGRTEEALQLYNQIIKLKPTDVALLAVIANNIITINKDQNVFDSKKKVKLTNAEGVEFKLSKKQLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPERLLPVLIQAAQLCREKQHTKAIELLQDYSDQHPENAAEIKLTMAQLKISQGNISKACLILRSIDELKHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQWYQNHQPKSTAHLSLIREAANFKLKYGRKKEAISDLEQLWKQNPKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSPGATYVRKKGGKVTGDNQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGKGTQGATAGASSELDASKTVSSPPTSPRPGSAATASTSTSNIIPPRHQKPAGAPATKKKQQQKKKKGGKGGW", "length": 671, "header": "tr|E1BB38-1|E1BB38_BOVIN Isoform 1 of Signal recognition particle subunit SRP72 OS=Bos taurus OX=9913 GN=SRP72 PE=1 SV=1 CANONICAL=E1BB38-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2A4-1", "url": "https://www.uniprot.org/uniprotkb/E1BB38/entry#A0AAA9S2A4-1", "sequence": { "sequence": "MASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVFANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCYNTACALIGQGQLSQAMRILQKAEDLCRRSFSEDSDQNVFDSKKKVKLTNAEGVEFKLSKKQLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPERLLPVLIQAAQLCREKQHTKAIELLQDYSDQHPENAAEIKLTMAQLKISQGNISKACLILRSIDELKHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQWYQNHQPKSTAHLSLIREAANFKLKYGRKKEAISDLEQLWKQNPKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSPGATYVRKKGGKVTGDNQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGKGTQGATAGASSELDASKTVSSPPTSPRPGSAATASTSTSNIIPPRHQKPAGAPATKKKQQQKKKKGGKGGW", "length": 610, "header": "tr|A0AAA9S2A4-1|E1BB38_BOVIN Computationally mapped isoform of Signal recognition particle subunit SRP72 OS=Bos taurus OX=9913 GN=SRP72 PE=1 SV=1 CANONICAL=E1BB38-1" }, "locus": { "chromosome": "6", "start_pos": 71871264, "end_pos": 71846150, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108515.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108515.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076233.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076233.1" } ] } }, { "isoform_ac": "A0AAA9TLM7-1", "url": "https://www.uniprot.org/uniprotkb/E1BB38/entry#A0AAA9TLM7-1", "sequence": { "sequence": "MASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVFANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCYNTACALIGQGQLSQAMRILQKAEGWTLVKIICKMHITLQ", "length": 219, "header": "tr|A0AAA9TLM7-1|E1BB38_BOVIN Computationally mapped isoform of Signal recognition particle subunit SRP72 OS=Bos taurus OX=9913 GN=SRP72 PE=1 SV=1 CANONICAL=E1BB38-1" }, "locus": { "chromosome": "6", "start_pos": 71851960, "end_pos": 71846150, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109465.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109465.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099330.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099330.1" } ] } }, { "isoform_ac": "E1BB38-1", "url": "https://www.uniprot.org/uniprotkb/E1BB38/entry#E1BB38-1", "sequence": { "sequence": "MASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVFANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCYNTACALIGQGQLSQAMRILQKAEDLCRRSFSEDSDGTEEDPQAELAIIHGQMAYILQLQGRTEEALQLYNQIIKLKPTDVALLAVIANNIITINKDQNVFDSKKKVKLTNAEGVEFKLSKKQLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPERLLPVLIQAAQLCREKQHTKAIELLQDYSDQHPENAAEIKLTMAQLKISQGNISKACLILRSIDELKHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQWYQNHQPKSTAHLSLIREAANFKLKYGRKKEAISDLEQLWKQNPKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSPGATYVRKKGGKVTGDNQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGKGTQGATAGASSELDASKTVSSPPTSPRPGSAATASTSTSNIIPPRHQKPAGAPATKKKQQQKKKKGGKGGW", "length": 671, "header": "tr|E1BB38-1|E1BB38_BOVIN Isoform 1 of Signal recognition particle subunit SRP72 OS=Bos taurus OX=9913 GN=SRP72 PE=1 SV=1 CANONICAL=E1BB38-1" }, "locus": { "chromosome": "6", "start_pos": 71871264, "end_pos": 71846150, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014015.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014015.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014015.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014015.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509430", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509430", "resource": "KEGG Pathway" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZUX3-1", "protein_name": "Signal recognition particle subunit SRP72", "gene_name": "Srp72", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASGGSGGVSVPALWSEVNRYGQNSDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPVSMRVTHTHTHPTAMNEYSYLLSDRHVSLWQENLGLQEGTHELCYNAACALIGQGQLTQAMKILQKAEDLCRRSFSEDSDGTEEDPQAELAIIHGQMAYIMQLQGRIEEALQLYNQIIKLKPTDVALLAVIANNIITINKDQNVFDSKKKVKLTNAEGVEFKLSKRQLQAIEFNKALLAMYTNQAEQCRKIASSLQSQSPEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLTMAQLKISQGNISKACLILRSIEELKHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQWYQSHQPKSPAHLSLIREAANFKLKYGRKKEAVSDLEQLWKQNSKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSPGATYIRKKGGKVTGDNQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGKGTQGATAGASSELDASKTVSSPPTSPRPGSAATMASSTSNIVPPRHQKPAGAPATKKKQQQKKKKGGKSGW", "length": 702 }, "evidence": [ { "id": "E1BB38", "url": "https://omabrowser.org/oma/group/E1BB38/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RTV6-1", "protein_name": "Signal recognition particle subunit SRP72", "gene_name": "SRP72", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASGGGGGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQIHKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKKRYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCYNTACALIGQGQLNQAMKILQKAEDLCRRSFSEDSDGAEEDPQAELAIIHGQMAYILQLQGRTEEALQLYNQIIKLKPTDVALLAVIANNIITINKDQNVFDSKKKVKLTNAEGVEFKLSKKQLQAIEFNKALLAMYTNQAEQCRKISTSLQSQSPQHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLTMAQLKISQACLILRSIEELKHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQWYQSHQPKSPAHLSLIREAANFKLKYGRKKEAVSDLEQLWKQNPKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVDALENSPGATYVRKKGGKVAGDNQPKEHGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGKGTQGASAGASSELDASKTVSSPPTSPRPGSAAAASTSTSNIIPPRHQKPAGAPATKKKQPQKKKRGGRGGW", "length": 657 }, "evidence": [ { "id": "E1BB38", "url": "https://omabrowser.org/oma/group/E1BB38/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F8VQC1-1", "protein_name": "Signal recognition particle subunit SRP72", "gene_name": "Srp72", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASGGSGGVSVPALWSEVNRYGQNSDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIESATQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCYNAACALIGQGQLTQAMKILQKAEDLCRRSFSEDSDGAEEDPQAELAIIHGQMAYIMQLQGRTEEALQLYNQIIKLKPTDVALLAVIANNIITINKDQNVFDSKKKVKLTNAEGVEFKLSKRQLQAIEFNKALLAMYTNQAEQCRKIAASLQSQSPEYLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLTMAQLKISQGNISKACLILRSIEELRHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQWYQSHQPKSPAHLSLIREAANFKLKYGRKKEAVSDLEQLWKQNSKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSPGATYIRKKGGKVTGDNQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGKGTQGATAGASSELDASKAVSSPPTSPRPGSAATISSSASNIVPPRHQKPAGAPATKKKQQQKKKKGGKSGW", "length": 671 }, "evidence": [ { "id": "E1BB38", "url": "https://omabrowser.org/oma/group/E1BB38/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O76094-1", "protein_name": "Signal recognition particle subunit SRP72", "gene_name": "SRP72", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCYNTACALIGQGQLNQAMKILQKAEDLCRRSLSEDTDGTEEDPQAELAIIHGQMAYILQLQGRTEEALQLYNQIIKLKPTDVGLLAVIANNIITINKDQNVFDSKKKVKLTNAEGVEFKLSKKQLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLTMAQLKISQGNISKACLILRSIEELKHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQWYQNHQPKSPAHLSLIREAANFKLKYGRKKEAISDLQQLWKQNPKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSAGATYIRKKGGKVTGDSQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGKGTQGATAGASSELDASKTVSSPPTSPRPGSAATVSASTSNIIPPRHQKPAGAPATKKKQQQKKKKGGKGGW", "length": 671 }, "evidence": [ { "id": "E1BB38", "url": "https://omabrowser.org/oma/group/E1BB38/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54EP7-1", "protein_name": "Signal recognition particle subunit SRP72", "gene_name": "srp72", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSKDTTVSLEQLFKELDEYIINSQFKKAIRVCNKILSVNGNDSEAFQCKVICLMQLSNFTEAIECFKKPEQIQSMQFEYSYCLYSTAKYQEALTQLEKQSSKETKSLELEAQIYYKLENYQKTISIYESLLSKPGYSDSIEFITNLCAVYLDAGKFNECQELLNKNKSQQTKTHELAFNSACLAISKNDTKTAETQLKLAKKICTDSLKKDGFSEEEIKEEQTSIDVQLGYVQQICGNLEKSLEQYQNVLEQQVGDSATLVATNNSISVRSILQSDQWSTQPKEYTHAMDSLKSLLTEAESTRLNSKQKKVINYNLCLLLVQLKKVSQCEELIKTLKSKYGQQQQQVDTSFVEDLDIIQVSLLIKEKKFKDAEKLLLKNNTTTGSIKSQLLLAQIYLLDNNNVAKALNVLEKLDSSVSLRPGIVATKVALYEKSGDLEKAVNSLDDLISIFDKQKKSEKDEEIYVNLLKASGNFKLKHHKYREASDMFDRVLKINPNDLIALPSYIVATSHFDPSLSQKYEGKLPNIKFESKIDIDLIEKYGLTFEKKLNLNEDSNSSSPTTTTTTTTKSTKPTATEVVKIKKSKKKLPKVMKPNYVPDPGRWLPKWQRANAKAARSKKNKDIIKGPQGIASASQTASLFVQESKNTNTNNNNTQSSKSEKPRNIHKKKSKK", "length": 672 }, "evidence": [ { "id": "E1BB38", "url": "https://omabrowser.org/oma/group/E1BB38/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9FXD4-1", "protein_name": "Signal recognition particle subunit SRP72", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAPKSKEKSKTSNSQPPPAIEDLFTSLHQHIKDTKYEEAVKVADQVLSIVPTDEDAIRCKVVALIKDDKFDDYLIKDVKINGALSVINSFQKLPIDLGFHKAYCLYRVNKLDEALVCLKGLERDTDTLVLEAQILYRLGKADACVDVYQKLTKSQIETLEVNLVAGLISAGKASQVQKTLESLKIKPTSSFELAYNTACSLIENNNYADAEQLLLTARRIGQETLNDDDIALTDEEIEIELAPIAVQLAYVQQILGQTQESTSSYVDFIKRNLADEPSLAVAVNNLVALKGFKDISDGLRKFDLLKDKDSQTFQLSQALDAKLSQKHKEAIYANRVLLLLHANKMDQARELCAALPGMFPESIIPTLLQAAVLVRENKAAKAEELLGQCAEKFPEKSKLVLLARAQIAASASHPHVAAESLSKIPDIQHLPATVATIVALKERAGDNDGAAAVLDSAIKWWSNSMTESSKLRVLMPEAAAFKLRHGQEEEASRLYEEIVKNHNSTDALVGLVTTLARVNVEKAESYEKQLKPLPGLKAVDVDKLEKTYGAKPIEGAAASSSQEEVKKEKAKRKRKRKPKYPKGFDPANPGPPPDPERWLPRRERSSYKPKRKDKRAAQIRGSQGAVTKDKQEAAPSTSKSNQVASSKGNAPAPSSKASKKKSRR", "length": 664 }, "evidence": [ { "id": "E1BB38", "url": "https://omabrowser.org/oma/group/E1BB38/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VDK7-1", "protein_name": "Signal recognition particle subunit SRP72", "gene_name": "Srp72", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSKDANPKEALIKAAYADVNKFGNNQEFDKAVKAVNRILGVAPDDPTALHCKVVCLVQLSKFEEAYKFIEKNRLSSLFFEKAYCEYQLNKQQQALKTIDDAGLQPLPPNLKELRTQVLYRLERYDECLDSYRDIIKNTSDEYEEERRTNLSAVAANLAVDQTKEVPEVPEDTYEQYFNSACIQANRQKYAEAERKLRTSEKLCLEDECASEEEIIEEVDVIRVQLAYVLQLQGKTKEASSIYADCLRHKPKDAALVAVASNNLVVVNKDQNVFDSKKKIRAALADACESRLTSRQKQVIALNNCLLALYTNAGDQVQQLSQKLAQTYPQVEFEALLIRCTQLAKDRKHKEAIEQLQKFAAAHKSHEFVSKFAIIQLQLLQGNRKDAIETLLSLGEAKYKPGVVSALVSLYLGTDNKTAASALLKSAVDWYKKNEVSSGDLSDMWRQAAEFHLRGGASETAASSLEELLKLNPNDTKVLAQLVIAYAQFQPKRALELSRKLPKLETLTTASEIDALEAANWVMSAKAAKKTANTKVEPSPSTPLEKKKNRNRKRKGKLPKNYNAEVAPDPERWLPKYERTGFRKKRGGARGKDVIKGSQGMASGAADQYDMSSRVNLTKNSPATPVYQETAPGPRQQHRKGGHKKKKGGRF", "length": 650 }, "evidence": [ { "id": "E1BB38", "url": "https://omabrowser.org/oma/group/E1BB38/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "signal recognition particle, endoplasmic reticulum targeting", "id": "GO:0005786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005786", "evidence": [ { "database": "UniProtKB", "id": "E1BB38", "url": "https://www.uniprot.org/uniprotkb/E1BB38" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "E1BB38", "url": "https://www.uniprot.org/uniprotkb/E1BB38" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BB38", "url": "https://www.uniprot.org/uniprotkb/E1BB38" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "SRP-dependent cotranslational protein targeting to membrane", "id": "GO:0006614", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006614", "evidence": [ { "database": "UniProtKB", "id": "E1BB38", "url": "https://www.uniprot.org/uniprotkb/E1BB38" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "7S RNA binding", "id": "GO:0008312", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008312", "evidence": [ { "database": "UniProtKB", "id": "E1BB38", "url": "https://www.uniprot.org/uniprotkb/E1BB38" } ], "pmid": "" }, { "name": "TPR domain binding", "id": "GO:0030911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030911", "evidence": [ { "database": "UniProtKB", "id": "E1BB38", "url": "https://www.uniprot.org/uniprotkb/E1BB38" } ], "pmid": "" }, { "name": "signal recognition particle binding", "id": "GO:0005047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005047", "evidence": [ { "database": "UniProtKB", "id": "E1BB38", "url": "https://www.uniprot.org/uniprotkb/E1BB38" } ], "pmid": "" }, { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "E1BB38", "url": "https://www.uniprot.org/uniprotkb/E1BB38" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 150, "end_pos": 152, "annotation": "n_glycosylation_sequon" }, { "start_pos": 388, "end_pos": 390, "annotation": "n_glycosylation_sequon" }, { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" }, { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BB38-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 671, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BB38-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BB38" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BB38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB38" }, { "id": "PF08492", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08492" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Signal recognition particle SRP72 subunit RNA-binding", "eco_id": "ECO_0000259", "start_pos": 532, "end_pos": 588, "start_aa": "Lys", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 150, "end_pos": 152 }, { "start_pos": 388, "end_pos": 390 }, { "start_pos": 58, "end_pos": 60 }, { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B9U7-1", "uniprot_ac": "E1B9U7", "uniprot_id": "E1B9U7_BOVIN", "mass": { "chemical_mass": 67778.0, "monoisotopic_mass": 67778.0 }, "refseq": { "ac": "NP_001178996", "name": "polypeptide N-acetylgalactosaminyltransferase 17", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178996" }, "gene_names": [ { "name": "GALNT17", "type": "recommended", "evidence": [ { "id": "E1B9U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9U7" } ] }, { "name": "GALNT17", "type": "synonym", "evidence": [ { "id": "NP_001178996", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178996" } ] }, { "name": "WBSCR17", "type": "synonym", "evidence": [ { "id": "NP_001178996", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178996" } ] } ], "protein_names": [ { "name": "Polypeptide N-acetylgalactosaminyltransferase", "type": "recommended", "evidence": [ { "id": "E1B9U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9U7/entry#names_and_taxonomy" } ] }, { "name": "2.4.1.-", "type": "synonym", "evidence": [ { "id": "E1B9U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9U7/entry#names_and_taxonomy" } ] }, { "name": "Protein-UDP acetylgalactosaminyltransferase", "type": "synonym", "evidence": [ { "id": "E1B9U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9U7/entry#names_and_taxonomy" } ] }, { "name": "Williams-Beuren syndrome chromosome region 17", "type": "synonym", "evidence": [ { "id": "NP_001178996", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178996" } ] }, { "name": "polypeptide N-acetylgalactosaminyltransferase 17", "type": "synonym", "evidence": [ { "id": "NP_001178996", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178996" } ] }, { "name": "putative polypeptide N-acetylgalactosaminyltransferase-like protein 3", "type": "synonym", "evidence": [ { "id": "NP_001178996", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178996" } ] } ], "function": [ { "annotation": "May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1B9U7", "url": "https://www.uniprot.org/uniprotkb/E1B9U7#function" }, { "database": "UniProtKB", "id": "ARBA00057019", "url": "https://www.uniprot.org/uniprotkb/ARBA00057019#function" }, { "database": "UniProtKB", "id": "A0AAA9S7R2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9U7", "url": "https://www.uniprot.org/uniprotkb/E1B9U7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GALNT17", "url": "https://www.uniprot.org/uniprotkb/E1B9U7", "locus": { "chromosome": "25", "start_pos": 29133705, "end_pos": 29563785, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008718", "url": "https://www.ensembl.org/id/ENSBTAG00000008718" } ] } } ], "crossref": [ { "id": "E1B9U7", "url": "https://alphafold.ebi.ac.uk/entry/E1B9U7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008718", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008718", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02510", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02510", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd23474", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23474", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505622", "url": "https://www.ncbi.nlm.nih.gov/gene/505622", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001173", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001173", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045885", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045885", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505622", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505622", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EENDAKY", "url": "https://omabrowser.org/oma/group/EENDAKY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B9U7", "url": "https://www.orthodb.org/?gene=E1B9U7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11675", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11675", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11675:SF38", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11675:SF38", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00535", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00535", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00652", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00652", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-913709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-913709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001178996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178996", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "23956", "url": "https://www.rhea-db.org/rhea/23956", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "52424", "url": "https://www.rhea-db.org/rhea/52424", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S7R2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7R2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7R2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9U7", "url": "https://www.uniprot.org/uniprotkb/E1B9U7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9U7-1", "url": "https://www.uniprot.org/uniprotkb/E1B9U7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASLRRVKVLLVLNLIAVAGFVLFLAKCRPISMRSGDSFHEIRPRAEAANISAHSASPIQDAVLKRLSLLEDIVYRQLNGLSKSLGLIEGYGGRGKGGLPATLSPAEEEKAKGPHEKYGYNSYLSEKISLDRSIPDYRPTKCKELKYSKELPQISIIFIFVNEALSVILRSVHSAVNHTPTHLLKEIILVDDNSDEEELKAPLEEYVHKRYPGLVKVVRNQKREGLIRARIEGWKVATGQVTGFFDAHVEFTAGWAEPVLSRIQENRKRVILPSIDNIKQDTFEVQRYENSAHGYSWELWCMYISPPKDWWDAGDPSLPIRTPAMIGCSFVVNRKFFGEIGLLDPGMDVYGGENIELGIKVWLCGGSMEVLPCSRVAHIERKKKPYNSNIGFYTKRNALRVAEVWMDDYKSHVYIAWNLPLENPGIDIGDVSERRALRKSLKCKNFQWYLDHVYPEMRRYNNTVAYGELRNNKAKDVCLDQGPMENHTAILYPCHGWGPQLARYTKEGFLHLGALGTTTLLPDTRCLVDNAKSRLPQLLDCDKVKSSLYKRWNFIQNGAIMNRGTGRCLEVENRGLAGIDLTLRSCTGQRWTIKNSIK", "length": 598, "header": "tr|E1B9U7-1|E1B9U7_BOVIN Isoform 1 of Polypeptide N-acetylgalactosaminyltransferase OS=Bos taurus OX=9913 GN=GALNT17 PE=3 SV=3 CANONICAL=E1B9U7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7R2-1", "url": "https://www.uniprot.org/uniprotkb/E1B9U7/entry#A0AAA9S7R2-1", "sequence": { "sequence": "MASLRRVKVLLVLNLIAVAGFVLFLAKCRPISMRSGDSFHEIRPRAEAANISAHSASPIQDAVLKRLSLLEDIVYRQLNASLFKDPRDYKGLSQTTQDNFSSPRSSTFKAPFPTEGLSKSLGLIEGYGGRGKGGLPATLSPAEEEKAKGPHEKYGYNSYLSEKISLDRSIPDYRPTKCKELKYSKELPQISIIFIFVNEALSVILRSVHSAVNHTPTHLLKEIILVDDNSDEEELKAPLEEYVHKRYPGLVKVVRNQKREGLIRARIEGWKVATGQVTGFFDAHVEFTAGWAEPVLSRIQENRKRVILPSIDNIKQDTFEVQRYENSAHGYSWELWCMYISPPKDWWDAGDPSLPIRTPAMIGCSFVVNRKFFGEIGLLDPGMDVYGGENIELGIKVWLCGGSMEVLPCSRVAHIERKKKPYNSNIGFYTKRNALRVAEVWMDDYKSHVYIAWNLPLENPGIDIGDVSERRALRKSLKCKNFQWYLDHVYPEMRRYNNTVAYGELRNNKAKDVCLDQGPMENHTAILYPCHGWGPQLARYTKEGFLHLGALGTTTLLPDTRCLVDNAKSRLPQLLDCDKVKSSLYKRWNFIQNGAIMNRGTGRCLEVENRGLAGIDLTLRSCTGQRWTIKNSIK", "length": 634, "header": "tr|A0AAA9S7R2-1|E1B9U7_BOVIN Computationally mapped isoform of Polypeptide N-acetylgalactosaminyltransferase OS=Bos taurus OX=9913 GN=GALNT17 PE=3 SV=1 CANONICAL=E1B9U7-1" }, "locus": { "chromosome": "25", "start_pos": 29563316, "end_pos": 29135057, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120867.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120867.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082064.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082064.1" } ] } }, { "isoform_ac": "E1B9U7-1", "url": "https://www.uniprot.org/uniprotkb/E1B9U7/entry#E1B9U7-1", "sequence": { "sequence": "MASLRRVKVLLVLNLIAVAGFVLFLAKCRPISMRSGDSFHEIRPRAEAANISAHSASPIQDAVLKRLSLLEDIVYRQLNGLSKSLGLIEGYGGRGKGGLPATLSPAEEEKAKGPHEKYGYNSYLSEKISLDRSIPDYRPTKCKELKYSKELPQISIIFIFVNEALSVILRSVHSAVNHTPTHLLKEIILVDDNSDEEELKAPLEEYVHKRYPGLVKVVRNQKREGLIRARIEGWKVATGQVTGFFDAHVEFTAGWAEPVLSRIQENRKRVILPSIDNIKQDTFEVQRYENSAHGYSWELWCMYISPPKDWWDAGDPSLPIRTPAMIGCSFVVNRKFFGEIGLLDPGMDVYGGENIELGIKVWLCGGSMEVLPCSRVAHIERKKKPYNSNIGFYTKRNALRVAEVWMDDYKSHVYIAWNLPLENPGIDIGDVSERRALRKSLKCKNFQWYLDHVYPEMRRYNNTVAYGELRNNKAKDVCLDQGPMENHTAILYPCHGWGPQLARYTKEGFLHLGALGTTTLLPDTRCLVDNAKSRLPQLLDCDKVKSSLYKRWNFIQNGAIMNRGTGRCLEVENRGLAGIDLTLRSCTGQRWTIKNSIK", "length": 598, "header": "tr|E1B9U7-1|E1B9U7_BOVIN Isoform 1 of Polypeptide N-acetylgalactosaminyltransferase OS=Bos taurus OX=9913 GN=GALNT17 PE=3 SV=3 CANONICAL=E1B9U7-1" }, "locus": { "chromosome": "25", "start_pos": 29563316, "end_pos": 29135057, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029707.5", "url": "https://www.ensembl.org/id/ENSBTAT00000029707.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029705.5", "url": "https://www.ensembl.org/id/ENSBTAP00000029705.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:505622", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505622", "resource": "KEGG Pathway" }, { "id": "R-BTA-913709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-913709", "resource": "Reactome", "description": "O-linked glycosylation of mucins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AKY0-1", "protein_name": "Polypeptide N-acetylgalactosaminyltransferase", "gene_name": "WBSCR17", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASLRRVKVLLVLNLIAVAGFVLFLAKCRPITAKSGDSFHDIHPRAEVVNLTARGISSIQDAVLKRLSLLEDIVYRQLNGLSKSLGLIEGYGGRGKGGLPATLSPEEEEKAKGPHEKYGYNSYLSEKISLDRSIPDYRPTKCKELKYGKDLPQISIIFIFVNEALSVILRSVHSAVNHTPAHLLKEIILVDDNSDEEELKAPLEEYVNKRYPGLVKVVRNQKREGLIRARIEGWKAATGHVTGFFDAHVEFTAGWAEPVLSRIQENRRRVILPSIDNIKQDNFEVQRYENSAHGYSWELWCMYISPPKDWWDAGDPSLPIRTPAMIGCSFVVHRKFFGEIGLLDPGMDVYGGENIELGIKVWLCGGSMEVLPCSRVAHIERKKKPYNNNIGFYTKRNALRVAEVWMDDYKSHVYIAWNLPLENPGIDIGDVSERKALRKSLKCKNFQWYLDHVYPEMRRYNNTVAYGELRNNKAKDVCLDQGPQENHTAILYPCHGWGPQLARYTKEGFLHLGALGTTTLLPDTRCLVDNVKSRFPQLLDCDKVKSSLHKRWNFIQNGAILNKGTGRCLEVENRGMAGIDLILRSCTGQRWTIKNFIK", "length": 598 }, "evidence": [ { "id": "E1B9U7", "url": "https://omabrowser.org/oma/group/E1B9U7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E7EZL6-1", "protein_name": "Polypeptide N-acetylgalactosaminyltransferase", "gene_name": "galnt17", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMRFTGFRTPKSFMAFVMRRWKILLVLNVFTVAGFITFWGKCNVRTTKGVGQQMAVDSRGQTNLNGSVQETSITHDVLLKRLGSLEDVVYRQLNGLSKSLGLIEGFGGRGRGGIPATLTPAEEKEAKFLREKYGYNAFLSDKISLDRSLPDYRPSKCKKAFFPRDLPQISIIFIFVNEALSVILRSVHSAVNHTPAHLLKEIILVDDNSDDVQLKGPLEEYVNKRYPGLIKIVRNQKREGLIRARIEGWKVATGEVTGFFDAHVEFTPAWAEPVLSRIKENHKRIILPSIDNIKDETFELERYENSGHGYNWELWCMYISPPKQWWDEGDTSAPIRTPAMIGCSFVVNREYFGDLGLLDAGMDVYGGENIELGIRVWLCGGSMEVLPCSRVAHIARTKKPYHSNIAFHTRRNALRVAEVWMDQYKSNVYLAWNLPMKNHGIDYGDVSERLALRKRLQCKSFDWYLDNIYPEMRRYNNTVFYGEIRNTNVTHLCVDQGIKENHTATLHPCHGWGPQLGRYTKEGYLFLGPLGSTGEDTRCVVDDKISSYPQLLNCEKVSSVRQKTWHFAQNESIISRATGRCLEVVPANVYFGYALILRSCTGQKWNIKNLMKQDQGQ", "length": 617 }, "evidence": [ { "id": "E1B9U7", "url": "https://omabrowser.org/oma/group/E1B9U7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5CD99-1", "protein_name": "Polypeptide N-acetylgalactosaminyltransferase", "gene_name": "Galnt17", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASLRRVKVLLVLNLIAVAGFVIFLAKCRPIAVRSGDAFHEIRPRAEVANLSAHSASPIQDAVLKRLSLLEDIVYRQLNGLSKSLGLIEGYGGRGKGGLPATLSPSEEEKAKGPHEKYGYNSYLSEKISLDRSIPDYRPTKCKELKYSKELPQISIIFIFVNEALSVILRSVHSAVNHTPTHLLKEIILVDDNSDEEELKAPLEEYVHKRYPGLVKVVRNQKREGLIRARIEGWKVATGQVTGFFDAHVEFTAGWAEPVLSRIQENRKRVILPSIDNIKQDNFEVQRYENSAHGYSWELWCMYISPPKDWWDAGDPSLPIRTPAMIGCSFVVNRKFFGEIGLLDPGMDVYGGENIELGIKVWLCGGSMEVLPCSRVAHIERKKKPYNSNIGFYTKRNALRVAEVWMDDYKSHVYIAWNLPLENPGIDIGDVSERKALRKSLKCKNFQWYLDHVYPEMRRYNNTIAYGELRNNKAKDVCLDQGPLENHTAILYPCHGWGPQLARYTKEGFLHLGALGTTTLLPDTRCLVDNSKSRLPQLLDCDKVKSSLYKRWNFIQNGAIMNKGTGRCLEVENRGLAGIDLILRSCTGQRWTIKNPIK", "length": 598 }, "evidence": [ { "id": "E1B9U7", "url": "https://omabrowser.org/oma/group/E1B9U7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6IS24-1", "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 17", "gene_name": "GALNT17", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASLRRVKVLLVLNLIAVAGFVLFLAKCRPIAVRSGDAFHEIRPRAEVANLSAHSASPIQDAVLKRLSLLEDIVYRQLNGLSKSLGLIEGYGGRGKGGLPATLSPAEEEKAKGPHEKYGYNSYLSEKISLDRSIPDYRPTKCKELKYSKDLPQISIIFIFVNEALSVILRSVHSAVNHTPTHLLKEIILVDDNSDEEELKVPLEEYVHKRYPGLVKVVRNQKREGLIRARIEGWKVATGQVTGFFDAHVEFTAGWAEPVLSRIQENRKRVILPSIDNIKQDNFEVQRYENSAHGYSWELWCMYISPPKDWWDAGDPSLPIRTPAMIGCSFVVNRKFFGEIGLLDPGMDVYGGENIELGIKVWLCGGSMEVLPCSRVAHIERKKKPYNSNIGFYTKRNALRVAEVWMDDYKSHVYIAWNLPLENPGIDIGDVSERRALRKSLKCKNFQWYLDHVYPEMRRYNNTVAYGELRNNKAKDVCLDQGPLENHTAILYPCHGWGPQLARYTKEGFLHLGALGTTTLLPDTRCLVDNSKSRLPQLLDCDKVKSSLYKRWNFIQNGAIMNKGTGRCLEVENRGLAGIDLILRSCTGQRWTIKNSIK", "length": 598 }, "evidence": [ { "id": "E1B9U7", "url": "https://omabrowser.org/oma/group/E1B9U7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7TT15-1", "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 17", "gene_name": "Galnt17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASLRRVKVLLVLNLIAVAGFVIFLAKCRPIAVRSGDAFHEIRPRAEVANLSAHSASPIQDAVLKRLSLLEDIVYRQLNGLSKSLGLIEGYGGRGKGGLPATLSPSEEEKAKGPHEKYGYNSYLSEKISLDRSIPDYRPTKCKELKYSKELPQISIIFIFVNEALSVILRSVHSAVNHTPTHLLKEIILVDDNSDEEELKAPLEEYVHKRYPGLVKVVRNQKREGLIRARIEGWKAATGQVTGFFDAHVEFTAGWAEPVLSRIQENRKRVILPSIDNIKQDNFEVQRYENSAHGYSWELWCMYISPPKDWWDAGDPSLPIRTPAMIGCSFVVNRKFFGEIGLLDPGMDVYGGENIELGIKVWLCGGSMEVLPCSRVAHIERKKKPYNSNIGFYTKRNALRVAEVWMDDYKSHVYIAWNLPLENPGIDIGDVSERKALRKSLKCKNFQWYLDHVYPEMRRYNNTIAYGELRNNKAKDVCLDQGPLENHTAILYPCHGWGPQLARYTKEGFLHLGALGTTTLLPDTRCLVDNSKSRLPQLLDCDKVKSSLYKRWNFIQNGAIMNKGTGRCLEVENRGLAGIDLILRSCTGQRWAIKNPIK", "length": 598 }, "evidence": [ { "id": "E1B9U7", "url": "https://omabrowser.org/oma/group/E1B9U7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "E1B9U7", "url": "https://www.uniprot.org/uniprotkb/E1B9U7" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "E1B9U7", "url": "https://www.uniprot.org/uniprotkb/E1B9U7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1B9U7", "url": "https://www.uniprot.org/uniprotkb/E1B9U7" } ], "pmid": "" }, { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "E1B9U7", "url": "https://www.uniprot.org/uniprotkb/E1B9U7" } ], "pmid": "" }, { "name": "polypeptide N-acetylgalactosaminyltransferase activity", "id": "GO:0004653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004653", "evidence": [ { "database": "UniProtKB", "id": "E1B9U7", "url": "https://www.uniprot.org/uniprotkb/E1B9U7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein O-linked glycosylation", "id": "GO:0006493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006493", "evidence": [ { "database": "UniProtKB", "id": "E1B9U7", "url": "https://www.uniprot.org/uniprotkb/E1B9U7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 461, "end_pos": 463, "annotation": "n_glycosylation_sequon" }, { "start_pos": 486, "end_pos": 488, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "23956", "name": "", "equation": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M986-1", "Q07537-1", "Q5EA41-1", "A0AAA9TS02-1", "A0AAA9S1Y7-1", "F1N554-1", "E1BDW8-1", "E1BHN6-1", "A0AAA9S5W3-1", "E1B9U7-1", "A0AAA9T153-1", "A0A3Q1N2Q7-1", "E1BPR6-1" ], "evidence": [ { "id": "23956", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23956" } ] }, { "id": "52424", "name": "", "equation": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M986-1", "Q07537-1", "Q5EA41-1", "A0AAA9TS02-1", "A0AAA9S1Y7-1", "F1N554-1", "E1BDW8-1", "E1BHN6-1", "A0AAA9S5W3-1", "E1B9U7-1", "A0AAA9T153-1", "A0A3Q1N2Q7-1", "E1BPR6-1" ], "evidence": [ { "id": "52424", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52424" } ] }, { "id": "R-BTA-913675", "name": "GALNTs transfer GalNAc to Mucins to form Tn antigens", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [ "R-ALL-9942384" ], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M986-1", "Q07537-1", "E1BDW8-1", "E1BHN6-1", "A0AAA9T153-1", "F1N554-1", "F6QA59-1", "F6RJ62-1", "A0AAA9S1Y7-1", "E1BPR6-1", "E1B9U7-1", "A0AAA9S5W3-1", "E1BKQ9-1" ], "evidence": [ { "id": "R-BTA-913675", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-913675" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-9942384", "participant_name": "UDP-GalNAc [Golgi lumen]", "crossref": [ { "id": "67138", "database": "ChEBI", "url": "" }, { "id": "ZINC000008551132", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M986", "gene_name": "GALNT2", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0A3Q1M986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M986" } ] } ] }, { "uniprot_ac": "A0A3Q1N2Q7", "gene_name": "GALNT12", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0A3Q1N2Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2Q7" } ] } ] }, { "uniprot_ac": "A0AAA9S1Y7", "gene_name": "GALNT14", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0AAA9S1Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Y7" } ] } ] }, { "uniprot_ac": "A0AAA9S5W3", "gene_name": "GALNT3", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0AAA9S5W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W3" } ] } ] }, { "uniprot_ac": "A0AAA9T153", "gene_name": "GALNT7", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0AAA9T153", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T153" } ] } ] }, { "uniprot_ac": "A0AAA9TS02", "gene_name": "GALNTL6", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0AAA9TS02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS02" } ] } ] }, { "uniprot_ac": "E1B9U7", "gene_name": "GALNT17", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "E1B9U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9U7" } ] } ] }, { "uniprot_ac": "E1BDW8", "gene_name": "GALNT11", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "E1BDW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDW8" } ] } ] }, { "uniprot_ac": "E1BHN6", "gene_name": "GALNT15", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "E1BHN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHN6" } ] } ] }, { "uniprot_ac": "E1BKQ9", "gene_name": "GALNT5", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "E1BKQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKQ9" } ] } ] }, { "uniprot_ac": "E1BPR6", "gene_name": "GALNT9", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "E1BPR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPR6" } ] } ] }, { "uniprot_ac": "F1N554", "gene_name": "GALNT10", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F1N554", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N554" } ] } ] }, { "uniprot_ac": "F6QA59", "gene_name": "GALNT8", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F6QA59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QA59" } ] } ] }, { "uniprot_ac": "F6RJ62", "gene_name": "GALNT18", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F6RJ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RJ62" } ] } ] }, { "uniprot_ac": "Q07537", "gene_name": "GALNT1", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q07537", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q07537" } ] }, { "ec_number": "2.4.1.41", "activity": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+).", "evidence": [ { "id": "Q07537", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q07537" } ] }, { "ec_number": "2.4.1.41", "activity": "", "evidence": [ { "id": "Q07537", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q07537" } ] } ] }, { "uniprot_ac": "Q5EA41", "gene_name": "GALNT6", "activity": [ { "ec_number": "2.4.1.41", "activity": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+).", "evidence": [ { "id": "Q5EA41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA41" } ] }, { "ec_number": "2.4.1.41", "activity": "", "evidence": [ { "id": "Q5EA41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA41" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9U7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 598, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9U7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9U7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9U7" }, { "id": "SM00458", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00458" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ricin B lectin", "eco_id": "ECO_0000259", "start_pos": 465, "end_pos": 594, "start_aa": "Ala", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [ { "glytoucan_ac": "G00027JG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G00030VN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00031MO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00032MO", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G00033MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00034MO", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00034UM", "type": "O-linked", "subtype": "Core 2" }, { "glytoucan_ac": "G00035MO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00036MO", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00037MO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G00038MO", "type": "O-linked", "subtype": "Core 4" }, { "glytoucan_ac": "G00039MO", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G00040MO", 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"total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B9D5-1", "uniprot_ac": "E1B9D5", "uniprot_id": "E1B9D5_BOVIN", "mass": { "chemical_mass": 51540.0, "monoisotopic_mass": 51540.0 }, "refseq": { "ac": "NP_001179902", "name": "alkylglycerol monooxygenase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179902" }, "gene_names": [ { "name": "AGMO", "type": "recommended", "evidence": [ { "id": "E1B9D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9D5" } ] }, { "name": "AGMO", "type": "synonym", "evidence": [ { "id": "NP_001179902", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179902" } ] }, { "name": "TMEM195", "type": "synonym", "evidence": [ { "id": "NP_001179902", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179902" } ] } ], "protein_names": [ { "name": "Alkylglycerol monooxygenase", "type": "recommended", "evidence": [ { "id": "E1B9D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9D5/entry#names_and_taxonomy" } ] }, { "name": "1.14.16.5", "type": "synonym", "evidence": [ { "id": "E1B9D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9D5/entry#names_and_taxonomy" } ] }, { "name": "Transmembrane protein 195", "type": "synonym", "evidence": [ { "id": "E1B9D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9D5/entry#names_and_taxonomy" } ] }, { "name": "alkylglycerol monooxygenase", "type": "synonym", "evidence": [ { "id": "NP_001179902", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179902" } ] }, { "name": "transmembrane protein 195", "type": "synonym", "evidence": [ { "id": "NP_001179902", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179902" } ] } ], "function": [ { "annotation": "Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SNG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNG5#function" }, { "database": "UniProtKB", "id": "ARBA00037122", "url": "https://www.uniprot.org/uniprotkb/ARBA00037122#function" }, { "database": "UniProtKB", "id": "A0AAA9SEM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM4#function" }, { "database": "UniProtKB", "id": "A0AAA9SPZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ9#function" }, { "database": "UniProtKB", "id": "A0AAA9TFH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFH2#function" }, { "database": "UniProtKB", "id": "A0AAA9TJJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJJ8#function" }, { "database": "UniProtKB", "id": "A0AAA9U081", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U081#function" }, { "database": "UniProtKB", "id": "A0AAA9U0M7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0M7#function" }, { "database": "UniProtKB", "id": "A0A3Q1LY82", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY82#function" }, { "database": "UniProtKB", "id": "E1B9D5", "url": "https://www.uniprot.org/uniprotkb/E1B9D5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9D5", "url": "https://www.uniprot.org/uniprotkb/E1B9D5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AGMO", "url": "https://www.uniprot.org/uniprotkb/E1B9D5", "locus": { "chromosome": "4", "start_pos": 23542270, "end_pos": 23947041, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034154", "url": "https://www.ensembl.org/id/ENSBTAG00000034154" } ] } } ], "crossref": [ { "id": "E1B9D5", "url": "https://alphafold.ebi.ac.uk/entry/E1B9D5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034154", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034154", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613658", "url": "https://www.ncbi.nlm.nih.gov/gene/613658", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006694", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006694", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051689", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051689", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613658", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613658", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FMPTGWR", "url": "https://omabrowser.org/oma/group/FMPTGWR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LY82", "url": "https://www.orthodb.org/?gene=A0A3Q1LY82", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B9D5", "url": "https://www.orthodb.org/?gene=E1B9D5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21624", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21624", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21624:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21624:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04116", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04116", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24858", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24858", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-75109", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75109", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179902", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "36255", "url": "https://www.rhea-db.org/rhea/36255", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LY82", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY82", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LY82-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY82-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNG5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPZ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U081", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U081", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U081-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U081-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0M7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0M7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0M7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0M7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9D5", "url": "https://www.uniprot.org/uniprotkb/E1B9D5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9D5-1", "url": "https://www.uniprot.org/uniprotkb/E1B9D5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKNPEAQQDVSVSQGIRMMFYVMKPSETSFQTLEEVPDYVRKATPFFISLMLLELVVSWIRKGKPSGGLDDALASLSAGIMSRLPRLFSRSIELTSYVYIWENYRLISLPWDSPWTWYLTFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEGYNLSTALRQSVLQIYTSWIFYSPLALFIPPSVYAVHLQFNLLYQFWIHTEVIDNLGPLELILNTPSHHRVHHGRNRYCIDRNFAGTLIIWDRIFGTFEAENEKVVYGLTHPINTFEPFKVQFHHLVNIWTTFWATPGFFNKFSVIFKGPGWSPGKPRLGLIEEIPEVEGKEIPFSSSASQLLKIYVLVQFALMLAFYEETFADKAVLSQVTLLLRVCFIILTLTSIGFLLDQRRKAAVLETFRCLVFLMLCRSGHLKPCLSSSSFAFEIFFSICIAFWGVRSVKQLVSDPWR", "length": 445, "header": "tr|E1B9D5-1|E1B9D5_BOVIN Isoform 1 of Alkylglycerol monooxygenase OS=Bos taurus OX=9913 GN=AGMO PE=3 SV=2 CANONICAL=E1B9D5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LY82-1", "url": "https://www.uniprot.org/uniprotkb/E1B9D5/entry#A0A3Q1LY82-1", "sequence": { "sequence": "MKNPEAQQDVSVSQGIRMMFYVMKPSETSFQTLEEVPDYVRKATPFFISLMLLELVVSWIRKGKPSGGLDDALASLSAGIMSRLPRLFSRSIELTSYVYIWENYRLISLPWDSPWTWYLTFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEGYNLSTALRQSVLQIYTSWIFYSPLALFIPPSVYAVHLQFNLLYQFWIHTEVIDNLGPLELILNTPSHHRVHHGRNRYCIDRNFAGTLIIWDRIFGTFEAENEKVVYGLTHPINTFEPFKVQFHHLVNIWTTFWATPGFFNKFSVIFKGPGWSPGKPRLGLIEEIPEVEGKEIPFSSSASQLLKIYVLVQFALMLAFYEETFADKAVLSQVTLLLRVCFIILTLTSIGFLLDQRRKAAVLETFRCLVFLMLCRSGHLKPCLSSSSFAFE", "length": 421, "header": "tr|A0A3Q1LY82-1|E1B9D5_BOVIN Computationally mapped isoform of Alkylglycerol monooxygenase OS=Bos taurus OX=9913 GN=AGMO PE=3 SV=2 CANONICAL=E1B9D5-1" }, "locus": { "chromosome": "4", "start_pos": 23946898, "end_pos": 23739978, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079787.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079787.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060591.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060591.2" } ] } }, { "isoform_ac": "A0AAA9SEM4-1", "url": "https://www.uniprot.org/uniprotkb/E1B9D5/entry#A0AAA9SEM4-1", "sequence": { "sequence": "MKNPEAQQDVSVSQGIRMMFYVMKPSETSFQTLEEVPDYVRKATPFFISLMLLELVVSWIRKGKPSGGLDDALASLSAGIMSRLPRLFSRSIELTSYVYIWENYRLISLPWDSPWTWYLTFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEGYNLSTALRQSVLQIYTSWIFYSPLALFIPPSVYAVHLQFNLLYQFWIHTEVIDNLGPLELILNTPSHHRVHHGRNRYCIDRNFAGTLIIWDRIFGTFEAENEKVVYGLTHPINTFEPFKVQFHHLVNIWTTFWATPGFFNKFSVIFKGPGWSPGKPRLGLIEEIPEVEGKEIPFSSSASQLLKIYVLVQFALMLAFYEETFADKAVLSQVTLLLRVCFIILTLTSIGFLLDQRRKAAVLETFRCLVFLMLCRSGHLKPCLSSSSFAFETKCSFTSKMMCAKSISVKDGYSFWTGYVGNLCNNGVRQPHDILRSCALSYTVSYRNKIIRLLICITLLKGTKGNKTNPENSLFLSNFSFSHMSKAWKCADTRGNVSTVWE", "length": 531, "header": "tr|A0AAA9SEM4-1|E1B9D5_BOVIN Computationally mapped isoform of Alkylglycerol monooxygenase OS=Bos taurus OX=9913 GN=AGMO PE=3 SV=1 CANONICAL=E1B9D5-1" }, "locus": { "chromosome": "4", "start_pos": 23946898, "end_pos": 23542523, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101994.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101994.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082295.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082295.1" } ] } }, { "isoform_ac": "A0AAA9SNG5-1", "url": "https://www.uniprot.org/uniprotkb/E1B9D5/entry#A0AAA9SNG5-1", "sequence": { "sequence": "MKNPEAQQDVSVSQGIRMMFYVMKPSETSFQTLEEVPDYVRKATPFFISLMLLELVVSWIRKGKPSGGLDDALASLSAGIMSRLPRLFSRSIELTSYVYIWENYRLISLPWDSPWTWYLTFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEGYNLSTALRQSVLQIYTSWIFYSPLALFIPPSVYAVHLQFNLLYQFWIHTEVIDNLGPLELILNTPSHHRVHHGRNRYCIDRNFAGTLIIWDRIFGTFEAENEKVVYGLTHPINTFEPFKVQFHHLVNIWTTFWATPGFFNKFSVIFKGPGWSPGKPRLGLIEEIPEVEGKEIPFSSSASQLLKIYVLVQFALMLAFYEETFADKAVLSQVTLLLRVCFIILTLTSIGFLLDQRRKAAVLETFRCLVFLMLCRSGHLKPCLSSSSFAFEQS", "length": 423, "header": "tr|A0AAA9SNG5-1|E1B9D5_BOVIN Computationally mapped isoform of Alkylglycerol monooxygenase OS=Bos taurus OX=9913 GN=AGMO PE=3 SV=1 CANONICAL=E1B9D5-1" }, "locus": { "chromosome": "4", "start_pos": 23946898, "end_pos": 23610033, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098055.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098055.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085510.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085510.1" } ] } }, { "isoform_ac": "A0AAA9SPZ9-1", "url": "https://www.uniprot.org/uniprotkb/E1B9D5/entry#A0AAA9SPZ9-1", "sequence": { "sequence": "MKNPEAQQDVSVSQGIRMMFYVMKPSETSFQTLEEVPDYVRKATPFFISLMLLELVVSWIRKGKPSGGLDDALASLSAGIMSRLPRLFSRSIELTSYVYIWENYRLISLPWDSPWTWYLTFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEGYNLSTALRQSVLQIYTSWIFYSPLALFIPPSVYAVHLQFNLLYQFWIHTEVIDNLGPLELILNTPSHHRVHHGRNRYCIDRNFAGTLIIWDRIFGTFEAENEKVVYGLTHPINTFEPFKVQFHHLVNIWTTFWATPGFFNKFSVIFKGPGWSPGKPRLGLIEEIPEVEGKEIPFSSSASQLLKIYVLVQFALMLAFYEETFADKAVLSQVTLLLRVCFIILTLTSIGFLLDQRRKAAVLETFRCLVFLMLCRSGHLKPCLSSSSFAFECISTESIK", "length": 429, "header": "tr|A0AAA9SPZ9-1|E1B9D5_BOVIN Computationally mapped isoform of Alkylglycerol monooxygenase OS=Bos taurus OX=9913 GN=AGMO PE=3 SV=1 CANONICAL=E1B9D5-1" }, "locus": { "chromosome": "4", "start_pos": 23946898, "end_pos": 23700145, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088678.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088678.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086059.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086059.1" } ] } }, { "isoform_ac": "A0AAA9TFH2-1", "url": "https://www.uniprot.org/uniprotkb/E1B9D5/entry#A0AAA9TFH2-1", "sequence": { "sequence": "MKNPEAQQDVSVSQGIRMMFYVMKPSETSFQTLEEVPDYVRKATPFFISLMLLELVVSWIRKGKPSGGLDDALASLSAGIMSRLPRLFSRSIELTSYVYIWENYRLISLPWDSPWTWYLTFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEGYNLSTALRQSVLQIYTSWIFYSPLALFIPPSVYAVHLQFNLLYQFWIHTEVIDNLGPLELILNTPSHHRVHHGRNRYCIDRNFAGTLIIWDRIFGTFEAENEKVVYGLTHPINTFEPFKVQFHHLVNIWTTFWATPGFFNKFSVIFKGPGWSPGKPRLGLIEEIPEVEGKEIPFSSSASQLLKIYVLVQFALMLAFYEETFADKAVLSQVTLLLRVCFIILTLTSIGFLLDQRRKAAVLETFRCLVFLMLCRSGHLKPCLSSSSFAFEETQVQSLGQEDPLEKEMATHSSILAWRISWTEEPGRLQSMASQESDMTERLNHHHHHAPWSELCFLVWTLPATHCES", "length": 498, "header": "tr|A0AAA9TFH2-1|E1B9D5_BOVIN Computationally mapped isoform of Alkylglycerol monooxygenase OS=Bos taurus OX=9913 GN=AGMO PE=3 SV=1 CANONICAL=E1B9D5-1" }, "locus": { "chromosome": "4", "start_pos": 23946898, "end_pos": 23601208, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128408.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128408.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096886.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096886.1" } ] } }, { "isoform_ac": "A0AAA9TJJ8-1", "url": "https://www.uniprot.org/uniprotkb/E1B9D5/entry#A0AAA9TJJ8-1", "sequence": { "sequence": "MKNPEAQQDVSVSQGIRMMFYVMKPSETSFQTLEEVPDYVRKATPFFISLMLLELVVSWIRKGKPSGGLDDALASLSAGIMSRLPRLFSRSIELTSYVYIWENYRLISLPWDSPWTWYLTFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEGYNLSTALRQSVLQIYTSWIFYSPLALFIPPSVYAVHLQFNLLYQFWIHTEVIDNLGPLELILNTPSHHRVHHGRNRYCIDRNFAGTLIIWDRIFGTFEAENEKVVYGLTHPINTFEPFKVQFHHLVNIWTTFWATPGFFNKFSVIFKGPGWSPGKPRLGLIEEIPEVEGKEIPFSSSASQLLKIYVLVQFALMLAFYEETFADKAVLSQVTLLLRVCFIILTLTSIGFLLDQRRKAAVLETFRCLVFLMLCRSGHLKPCLSSSSFAFEETQVQSLGQEDPLEKEMATHSSILAWRISWTEEPGRLQSMASQESDMTERLNHHHHHAPWSELCFLVWTLPATHYIFFHLHCFLGSKECEATCLRPLEITYVCTQFSCFNHLSTIVICYNS", "length": 542, "header": "tr|A0AAA9TJJ8-1|E1B9D5_BOVIN Computationally mapped isoform of Alkylglycerol monooxygenase OS=Bos taurus OX=9913 GN=AGMO PE=3 SV=1 CANONICAL=E1B9D5-1" }, "locus": { "chromosome": "4", "start_pos": 23946898, "end_pos": 23557859, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113989.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113989.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096422.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096422.1" } ] } }, { "isoform_ac": "A0AAA9U081-1", "url": "https://www.uniprot.org/uniprotkb/E1B9D5/entry#A0AAA9U081-1", "sequence": { "sequence": "MKNPEAQQDVSVSQGIRMMFYVMKPSETSFQTLEEVPDYVRKATPFFISLMLLELVVSWIRKGKPSGGLDDALASLSAGIMSRLPRLFSRSIELTSYVYIWENYRLISLPWDSPWTWYLTFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEGYNLSTALRQSVLQIYTSWIFYSPLALFIPPSVYAVHLQFNLLYQFWIHTEVIDNLGPLELILNTPSHHRVHHGRNRYCIDRNFAGTLIIWDRIFGTFEAENEKVVYGLTHPINTFEPFKVQFHHLVNIWTTFWATPGFFNKFSVIFKGPGWSPGKPRLGLIEEIPEVEGKEIPFSSSASQLLKIYVLVQFALMLAFYEETFADKAVLSQVTLLLRVCFIILTLTSIGFLLDQRRKAAVLETFRCLVFLMLCRSGHLKPCLSSSSFAFEEAALQLTEQEWDPDVF", "length": 437, "header": "tr|A0AAA9U081-1|E1B9D5_BOVIN Computationally mapped isoform of Alkylglycerol monooxygenase OS=Bos taurus OX=9913 GN=AGMO PE=3 SV=1 CANONICAL=E1B9D5-1" }, "locus": { "chromosome": "4", "start_pos": 23946898, "end_pos": 23595197, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090252.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090252.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103977.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103977.1" } ] } }, { "isoform_ac": "A0AAA9U0M7-1", "url": "https://www.uniprot.org/uniprotkb/E1B9D5/entry#A0AAA9U0M7-1", "sequence": { "sequence": "MDCSLPGFSAHGIFQATPFFISLMLLELVVSWIRKGKPSGGLDDALASLSAGIMSRLPRLFSRSIELTSYVYIWENYRLISLPWDSPWTWYLTFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEGYNLSTALRQSVLQIYTSWIFYSPLALFIPPSVYAVHLQFNLLYQFWIHTEVIDNLGPLELILNTPSHHRVHHGRNRYCIDRNFAGTLIIWDRIFGTFEAENEKVVYGLTHPINTFEPFKVQFHHLVNIWTTFWATPGFFNKFSVIFKGPGWSPGKPRLGLIEEIPEVEGKEIPFSSSASQLLKIYVLVQFALMLAFYEETFADKAVLSQVTLLLRVCFIILTLTSIGFLLDQRRKAAVLETFRCLVFLMLCRSGHLKPCLSSSSFAFEIFFSICIAFWGVRSVKQLVSDPWR", "length": 418, "header": "tr|A0AAA9U0M7-1|E1B9D5_BOVIN Computationally mapped isoform of Alkylglycerol monooxygenase OS=Bos taurus OX=9913 GN=AGMO PE=3 SV=1 CANONICAL=E1B9D5-1" }, "locus": { "chromosome": "4", "start_pos": 23945385, "end_pos": 23557927, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093573.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093573.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103193.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103193.1" } ] } }, { "isoform_ac": "E1B9D5-1", "url": "https://www.uniprot.org/uniprotkb/E1B9D5/entry#E1B9D5-1", "sequence": { "sequence": "MKNPEAQQDVSVSQGIRMMFYVMKPSETSFQTLEEVPDYVRKATPFFISLMLLELVVSWIRKGKPSGGLDDALASLSAGIMSRLPRLFSRSIELTSYVYIWENYRLISLPWDSPWTWYLTFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEGYNLSTALRQSVLQIYTSWIFYSPLALFIPPSVYAVHLQFNLLYQFWIHTEVIDNLGPLELILNTPSHHRVHHGRNRYCIDRNFAGTLIIWDRIFGTFEAENEKVVYGLTHPINTFEPFKVQFHHLVNIWTTFWATPGFFNKFSVIFKGPGWSPGKPRLGLIEEIPEVEGKEIPFSSSASQLLKIYVLVQFALMLAFYEETFADKAVLSQVTLLLRVCFIILTLTSIGFLLDQRRKAAVLETFRCLVFLMLCRSGHLKPCLSSSSFAFEIFFSICIAFWGVRSVKQLVSDPWR", "length": 445, "header": "tr|E1B9D5-1|E1B9D5_BOVIN Isoform 1 of Alkylglycerol monooxygenase OS=Bos taurus OX=9913 GN=AGMO PE=3 SV=2 CANONICAL=E1B9D5-1" }, "locus": { "chromosome": "4", "start_pos": 23946898, "end_pos": 23557927, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048415.4", "url": "https://www.ensembl.org/id/ENSBTAT00000048415.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045459.3", "url": "https://www.ensembl.org/id/ENSBTAP00000045459.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 288, "start_aa": "Thr", "end_pos": 288, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr288", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:613658", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613658", "resource": "KEGG Pathway" }, { "id": "R-BTA-75109", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75109", "resource": "Reactome", "description": "Triglyceride biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0JPQ8-1", "protein_name": "Alkylglycerol monooxygenase", "gene_name": "Agmo", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRNPGAQDNVSVSQGMRAMFYMMKPSETAFQTVEEVPDYVKKATPFFIFLILLELVVSWILKGKPSGRLDDILTSMSAGVVSRLPNLFFRSLEVTSYIYIWENYRVCELPWDSPWTWYLTFLGVDFGYYWFHRMAHEINIIWAAHQAHHSSEDYNLSTALRQSVLQQYSSWVFYCPLALFVPPSVFAVHIQFNLLYQFWIHTEVIRTLGPLELVLNTPSHHRVHHGRNRYCIDKNYAGTLIIWDRIFGTFEAENEQVIYGLTHPIGTFEPFKVQFHHLLYIWTTFWATPGFCHKFSVLFKGPGWGPGKPRLGLSEEIPEVTGQEVPFTSSASQFLKIYAVLQFAVMLVFYEETFANTAVLSQVTILLRICFIILTLTSIGFLLDQRPKAAIVETLRCLLFLTLYRFGHLKPLIESLSFAFEIFFSVCIAFWGVRSITHLASGSWKKP", "length": 447 }, "evidence": [ { "id": "E1B9D5", "url": "https://omabrowser.org/oma/group/E1B9D5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6ZNB7-1", "protein_name": "Alkylglycerol monooxygenase", "gene_name": "AGMO", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKNPEAQQDVSVSQGFRMLFYTMKPSETSFQTLEEVPDYVKKATPFFISLMLLELVVSWILKGKPPGRLDDALTSISAGVLSRLPSLFFRSIELTSYIYIWENYRLFNLPWDSPWTWYSAFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEDYNLSTALRQSVLQIYTSWIFYSPLALFIPPSVYAVHLQFNLLYQFWIHTEVINNLGPLELILNTPSHHRVHHGRNRYCIDKNYAGVLIIWDKIFGTFEAENEKVVYGLTHPINTFEPIKVQFHHLFSIWTTFWATPGFFNKFSVIFKGPGWGPGKPRLGLSEEIPEVTGKEVPFSSSSSQLLKIYTVVQFALMLAFYEETFADTAALSQVTLLLRVCFIILTLTSIGFLLDQRPKAAIMETLRCLMFLMLYRFGHLKPLVPSLSSAFEIVFSICIAFWGVRSMKQLTSHPWK", "length": 445 }, "evidence": [ { "id": "E1B9D5", "url": "https://omabrowser.org/oma/group/E1B9D5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BS35-1", "protein_name": "Alkylglycerol monooxygenase", "gene_name": "Agmo", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRSPGAQDNVSVSQGMRAMFYMMEPSETAFQTVEEVPDYVKKATPFFIFLILLELVISWILKGKPSGRLDDALTSISAGVVSRLPSLFFRSLEVTSYIYIWENYRLLELPWDSTWTWYFTFLGVDFGYYWFHRMAHEINIFWAAHQAHHSSEDYNLSTALRQSVLQQYSSWVFYCPLALFIPPSVFAVHIQFNLLYQFWIHTEIIRTLGPLEVILNTPSHHRVHHGRNRYCIDKNYAGTLIIWDRIFGTFEAENEQVIYGLTHPIGTFEPFNVQFHHLLYIWTTFWTTPGFCHKFSVLFKGPGWGPGKPRLGLSEEIPEVTGQEVPFSSSASQLLKIYTVLQFAVMLAFYEETFANTAVLSQVTLLLRIFFFILTLTSIGFLLDQRSKAATMETFRCLLFLTLHRFGHLKPLIPSLSFAFEIFFSVCIAFWGVRSITQLTSGSWKKP", "length": 447 }, "evidence": [ { "id": "E1B9D5", "url": "https://omabrowser.org/oma/group/E1B9D5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "E1B9D5", "url": "https://www.uniprot.org/uniprotkb/E1B9D5" } ], "pmid": "" }, { "name": "glyceryl-ether monooxygenase activity", "id": "GO:0050479", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050479", "evidence": [ { "database": "UniProtKB", "id": "E1B9D5", "url": "https://www.uniprot.org/uniprotkb/E1B9D5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "lipid biosynthetic process", "id": "GO:0008610", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008610", "evidence": [ { "database": "UniProtKB", "id": "E1B9D5", "url": "https://www.uniprot.org/uniprotkb/E1B9D5" } ], "pmid": "" }, { "name": "membrane lipid metabolic process", "id": "GO:0006643", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006643", "evidence": [ { "database": "UniProtKB", "id": "E1B9D5", "url": "https://www.uniprot.org/uniprotkb/E1B9D5" } ], "pmid": "" }, { "name": "triglyceride biosynthetic process", "id": "GO:0019432", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019432", "evidence": [ { "database": "UniProtKB", "id": "E1B9D5", "url": "https://www.uniprot.org/uniprotkb/E1B9D5" } ], "pmid": "" }, { "name": "ether lipid metabolic process", "id": "GO:0046485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046485", "evidence": [ { "database": "UniProtKB", "id": "E1B9D5", "url": "https://www.uniprot.org/uniprotkb/E1B9D5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "E1B9D5", "url": "https://www.uniprot.org/uniprotkb/E1B9D5" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "E1B9D5", "url": "https://www.uniprot.org/uniprotkb/E1B9D5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "36255", "name": "", "equation": "1-O-(1,2-saturated-alkyl)-sn-glycerol + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 = a 1-(1-hydroxyalkyl)-sn-glycerol + (6R)-L-erythro-6,7-dihydrobiopterin + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1B9D5-1" ], "evidence": [ { "id": "36255", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36255" } ] }, { "id": "R-BTA-5696119", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-29870", "R-ALL-5696122" ], "output_participant_list": [ "R-ALL-5696116" ], "enzyme_list": [ "E1B9D5-1" ], "evidence": [ { "id": "R-BTA-5696119", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696119" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-29870", "participant_name": "BH4 [cytosol]", "crossref": [ { "id": "59560", "database": "ChEBI", "url": "" }, { "id": "5276", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "ZINC000013585233", "database": "ZINC", "url": "" }, { "id": "HMDB0000027", "database": "HMDB Metabolite", "url": "" }, { "id": "C00272", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-5696116", "participant_name": "fatty aldehyde [cytosol]", "crossref": [ { "id": "35746", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-5696122", "participant_name": "alkylglycerol [cytosol]", "crossref": [ { "id": "52575", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "E1B9D5", "gene_name": "AGMO", "activity": [ { "ec_number": "1.14.16.5", "activity": "1-O-(1,2-saturated-alkyl)-sn-glycerol + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 = a 1-(1-hydroxyalkyl)-sn-glycerol + (6R)-L-erythro-6,7-dihydrobiopterin + H2O.", "evidence": [ { "id": "E1B9D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9D5" } ] }, { "ec_number": "1.14.16.5", "activity": "", "evidence": [ { "id": "E1B9D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9D5" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9D5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 445, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9D5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9D5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9D5" }, { "id": "PF24858", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24858" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Alkylglycerol monooxygenase C-terminal", "eco_id": "ECO_0000259", "start_pos": 335, "end_pos": 422, "start_aa": "Leu", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B9D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9D5" }, { "id": "PF04116", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04116" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fatty acid hydroxylase", "eco_id": "ECO_0000259", "start_pos": 118, "end_pos": 249, "start_aa": "Tyr", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.14.16.5", "ec_name": "1-O-(1,2-saturated-alkyl)-sn-glycerol + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 = a 1-(1-hydroxyalkyl)-sn-glycerol + (6R)-L-erythro-6,7-dihydrobiopterin + H2O.", "evidence": [ { "id": "1.14.16.5", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.16.5" }, { "id": "1.14.16.5", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.14.16.5" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 288 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 155, "end_pos": 157 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { 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"url": "https://www.uniprot.org/uniprotkb/E1BB89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB89-1", "url": "https://www.uniprot.org/uniprotkb/E1BB89-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVPPGPGSRGQRWWGASGVPMQEAATRGEVGMGDRARLTRDSVFFQTEGEGGGASPPAPQRMQFFGRLVNTLSSVTNLFVNPFRVKEVAVEDYHSRRRVREEGQLILFQNSSNRTWDCILVNPRNAQSGFRLFQLETEADALVNFQQYSSQLPPFYESSTHILQAEVLQQLTDLIRSHPSWSVAHLAVELGIRECFHHSHIISCANNKENEEGCTPLHLACRKGDTEVLSELVQHCRANMDVTDNSGETAFHYAVQGDSSQVLQLLGKNASGGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPGGYPIHTAMKFSQKGCAEMIVSMDSSQIHSKDPRYGASPLHWAKNAEMARLLLKRGCDVNGTSSAGNTALHVAVMRNRFDCVMVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPAFIASRISKLVTRKALLTLLRTVGADYRFPLTQGFSTEQCSAAAPSFSMERSHPPPISLNNLELQDITQISRARKPAFILSSMRDEKRTHDHLLCLDGGGVKGLVIIQLLIAIEKASGIATKDLFDWVAGTSTGGILALAILHSKSMAYMRGVYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVKKPKVMLTGTLSDRQPAELHLFRNYEAPECVREPRFSQNVNLKPPTHPSEQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQDSKVKKLSVVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGRMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEINDTVLVNALWETEVYIYEHREQFQKLVQLLLSP", "length": 866, "header": "tr|E1BB89-1|E1BB89_BOVIN Isoform 1 of 85/88 kDa calcium-independent phospholipase A2 OS=Bos taurus OX=9913 GN=PLA2G6 PE=4 SV=3 CANONICAL=E1BB89-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LN87-1", "url": "https://www.uniprot.org/uniprotkb/E1BB89/entry#A0A3Q1LN87-1", "sequence": { "sequence": "MQEAATRGEVGMGDRARLTRDSVFFQTEGEGGGASPPAPQRMQFFGRLVNTLSSVTNLFVNPFRVKEVAVEDYHSRRRVREEGQLILFQNSSNRTWDCILVNPRNAQSGFRLFQLETEADALVNFQQYSSQLPPFYESSTHILQAEVLQQLTDLIRSHPSWSVAHLAVELGIRECFHHSHIISCANNKENEEGCTPLHLACRKGDTEVLSELVQHCRANMDVTDNSGETAFHYAVQGDSSQVLQLLGKNASGGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPGGYPIHTAMKFSQKGCAEMIVSMDSSQIHSKDPRYGASPLHWAKNAEMARLLLKRGCDVNGTSSAGNTALHVAVMRNRFDCVMVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPAFIASRISKQLQDITQISRARKPAFILSSMRDEKRTHDHLLCLDGGGVKGLVIIQLLIAIEKASGIATKDLFDWVAGTSTGGILALAILHSKSMAYMRGVYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVKKPKVMLTGTLSDRQPAELHLFRNYEAPECVREPRFSQNVNLKPPTHPSEQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQDSKVKKLSVVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGRMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEINDTVLVNALWETEVYIYEHREQFQKLVQLLLSP", "length": 793, "header": "tr|A0A3Q1LN87-1|E1BB89_BOVIN Computationally mapped isoform of 85/88 kDa calcium-independent phospholipase A2 OS=Bos taurus OX=9913 GN=PLA2G6 PE=4 SV=1 CANONICAL=E1BB89-1" }, "locus": { "chromosome": "5", "start_pos": 109938646, "end_pos": 109892455, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067616.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067616.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058418.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058418.1" } ] } }, { "isoform_ac": "A0A3Q1M361-1", "url": "https://www.uniprot.org/uniprotkb/E1BB89/entry#A0A3Q1M361-1", "sequence": { "sequence": "MQEAATRGEVGMGDRARLTRDSVFFQTEGEGGGASPPAPQRMQFFGRLVNTLSSVTNLFVNPFRVKEVAVEDYHSRRRVREEGQLILFQNSSNRTWDCILVNPRNAQSGFRLFQLETEADALVNFQQYSSQLPPFYESSTHILQAEVLQQLTDLIRSHPSWSVAHLAVELGIRECFHHSHIISCANNKENEEGCTPLHLACRKGDTEVLSELVQHCRANMDVTDNSGETAFHYAVQGDSSQVLQLLGKNASGGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPGGYPIHTAMKFSQKGCAEMIVSMDSSQIHSKDPRYGASPLHWAKNAEMARLLLKRGCDVNGTSSAGNTALHVAVMRNRFDCVMVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPAFIASRISKLVTRKALLTLLRTVGADYRFPLTQGFSTEQCSAAAPSFSMERSHPPPISLNNLELQDITQISRARKPAFILSSMRDEKRTHDHLLCLDGGGVKGLVIIQLLIAIEKASGIATKDLFDWVAGTSTGGILALAILHSKSMAYMRGVYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVKKPKVMLTGTLSDRQPAELHLFRNYEAPECVREPRFSQNVNLKPPTHPSEQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEINDTVLVNALWETEVYIYEHREQFQKLVQLLLSP", "length": 790, "header": "tr|A0A3Q1M361-1|E1BB89_BOVIN Computationally mapped isoform of 85/88 kDa calcium-independent phospholipase A2 OS=Bos taurus OX=9913 GN=PLA2G6 PE=4 SV=1 CANONICAL=E1BB89-1" }, "locus": { "chromosome": "5", "start_pos": 109938646, "end_pos": 109892455, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069092.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069092.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064276.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064276.1" } ] } }, { "isoform_ac": "A0AAA9SF92-1", "url": "https://www.uniprot.org/uniprotkb/E1BB89/entry#A0AAA9SF92-1", "sequence": { "sequence": "MNELSFKHRIFQMQAQQMPRQGSPGARTEGEGGGASPPAPQRMQFFGRLVNTLSSVTNLFVNPFRVKEVAVEDYHSRRRVREEGQLILFQNSSNRTWDCILVNPRNAQSGFRLFQLETEADALVNFQQYSSQLPPFYESSTHILQAEVLQQLTDLIRSHPSWSVAHLAVELGIRECFHHSHIISCANNKENEEGCTPLHLACRKGDTEVLSELVQHCRANMDVTDNSGETAFHYAVQGDSSQVLQLLGKNASGGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPGGYPIHTAMKFSQKGCAEMIVSMDSSQIHSKDPRYGASPLHWAKNAEMARLLLKRGCDVNGTSSAGNTALHVAVMRNRFDCVMVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPAFIASRISKLVTRKALLTLLRTVGADYRFPLTQGFSTEQCSAAAPSFSMERSHPPPISLNNLELQDITQISRARKPAFILSSMRDEKRTHDHLLCLDGGGVKGLVIIQLLIAIEKASGIATKDLFDWVAGTSTGGILALAILHSKSMAYMRGVYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVKKPKVMLTGTLSDRQPAELHLFRNYEAPECVREPRFSQNVNLKPPTHPSEQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQDSKVKKLSVVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGRMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEINDTVLVNALWETEVYIYEHREQFQKLVQLLLSP", "length": 847, "header": "tr|A0AAA9SF92-1|E1BB89_BOVIN Computationally mapped isoform of 85/88 kDa calcium-independent phospholipase A2 OS=Bos taurus OX=9913 GN=PLA2G6 PE=4 SV=1 CANONICAL=E1BB89-1" }, "locus": { "chromosome": "5", "start_pos": 109944617, "end_pos": 109892455, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115735.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115735.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082278.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082278.1" } ] } }, { "isoform_ac": "A0AAA9T880-1", "url": "https://www.uniprot.org/uniprotkb/E1BB89/entry#A0AAA9T880-1", "sequence": { "sequence": "MQEAATRGEVGMGDRARLTRDSVFFQTEGEGGGASPPAPQRMQFFGRLVNTLSSVTNLFVNPFRVKEVAVEDYHSRRRVREEGQLILFQNSSNRTWDCILVNPRNAQSGFRLFQLETEADALVNFQQYSSQLPPFYESSTHILQAEVLQQLTDLIRSHPSWSVAHLAVELGIRECFHHSHIISCANNKENEEGCTPLHLACRKGDTEVLSELVQHCRANMDVTDNSGETAFHYAVQGDSSQVLQLLGKNASGGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPGGYPIHTAMKFSQKGCAEMIVSMDSSQIHSKDPRYGASPLHWAKNAEMARLLLKRGCDVNGTSSAGNTALHVAVMRNRFDCVMVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPAFIASRISKLVTRKALLTLLRTVGADYRFPLTQGFSTEQCSAAAPSFSMERSHPPPISLNNLELQDITQISRARKPAFILSSMRDEKRTHDHLLCLDGGGVKGLVIIQLLIAIEKASGIATKDLFDWVAGTSTGGILALAILHSKSMAYMRGVYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVKKPKVMLTGTLSDRQPAELHLFRNYEAPECVREPRFSQNVNLKPPTHPSEQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQDSKVKKLSVVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGRMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEINDTVLVNALWETEAALGPQTRPGGAGLPV", "length": 842, "header": "tr|A0AAA9T880-1|E1BB89_BOVIN Computationally mapped isoform of 85/88 kDa calcium-independent phospholipase A2 OS=Bos taurus OX=9913 GN=PLA2G6 PE=4 SV=1 CANONICAL=E1BB89-1" }, "locus": { "chromosome": "5", "start_pos": 109938646, "end_pos": 109892326, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118432.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118432.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092052.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092052.1" } ] } }, { "isoform_ac": "A0AAA9TGE1-1", "url": "https://www.uniprot.org/uniprotkb/E1BB89/entry#A0AAA9TGE1-1", "sequence": { "sequence": "MQEAATRGEVGMGDRARLTRDSVFFQTEGEGGGASPPAPQRMQFFGRLVNTLSSVTNLFVNPFRVKEVAVEDYHSRRRVREEGQLILFQNSSNRTWDCILVNPRNAQSGFRLFQLETEADALVNFQQYSSQLPPFYESSTHILQAEVLQQLTDLIRSHPSWSVAHLAVELGIRECFHHSHIISCANNKENEEGCTPLHLACRKGDTEVLSELVQHCRANMDVTDNSGETAFHYAVQGDSSQVLQLLGKNASGGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPGGYPIHTAMKFSQKGCAEMIVSMDSSQIHSKDPRYGASPLHWAKNAEMARLLLKRGCDVNGTSSAGNTALHVAVMRNRFDCVMVLLTHGANADARGEHGNTPLHLAMSARESTRERDVSPALRSPGGRPVGASWELCPASPAAPPPDVHCACSGEGAAVREDMLSFFLTQPAPWTQWEGLSLITFSCYSCKRSAADPSVSPCLWKDNVEMIKALIVFGAEVDTPNDFGETPAFIASRISKLVTRKALLTLLRTVGADYRFPLTQGFSTEQCSAAAPSFSMERSHPPPISLNNLELQDITQISRARKPAFILSSMRDEKRTHDHLLCLDGGGVKGLVIIQLLIAIEKASGIATKDLFDWVAGTSTGGILALAILHSKSMAYMRGVYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVKKPKVMLTGTLSDRQPAELHLFRNYEAPECVREPRFSQNVNLKPPTHPSEQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQDSKVKKLSVVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGRMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEINDTVLVNALWETEVYIYEHREQFQKLVQLLLSP", "length": 942, "header": "tr|A0AAA9TGE1-1|E1BB89_BOVIN Computationally mapped isoform of 85/88 kDa calcium-independent phospholipase A2 OS=Bos taurus OX=9913 GN=PLA2G6 PE=4 SV=1 CANONICAL=E1BB89-1" }, "locus": { "chromosome": "5", "start_pos": 109938646, "end_pos": 109892455, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132343.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132343.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095242.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095242.1" } ] } }, { "isoform_ac": "A0AAA9TRV5-1", "url": "https://www.uniprot.org/uniprotkb/E1BB89/entry#A0AAA9TRV5-1", "sequence": { "sequence": "MQFFGRLVNTLSSVTNLFVNPFRVKEVAVEDYHSRRRVREEGQLILFQNSSNRTWDCILVNPRNAQSGFRLFQLETEADALVNFQQYSSQLPPFYESSTHILQAEVLQQLTDLIRSHPSWSVAHLAVELGIRECFHHSHIISCANNKENEEGCTPLHLACRKGDTEVLSELVQHCRANMDVTDNSGETAFHYAVQGDSSQVLQLLGKNASGGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPGGYPIHTAMKFSQKGCAEMIVSMDSSQIHSKDPRYGASPLHWAKNAEKDNVEMIKALIVFGAEVDTPNDFGETPAFIASRISKLVTRKALLTLLRTVGADYRFPLTQGFSTEQCSAAAPSFSMERSHPPPISLNNLELQDITQISRARKPAFILSSMRDEKRTHDHLLCLDGGGVKGLVIIQLLIAIEKASGIATKDLFDWVAGTSTGGILALAILHSKSMAYMRGVYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVKKPKVMLTGTLSDRQPAELHLFRNYEAPECVREPRFSQNVNLKPPTHPSEQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQDSKVKKLSVVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGRMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEINDTVLVNALWETEVYIYEHREQFQKLVQLLLSP", "length": 744, "header": "tr|A0AAA9TRV5-1|E1BB89_BOVIN Computationally mapped isoform of 85/88 kDa calcium-independent phospholipase A2 OS=Bos taurus OX=9913 GN=PLA2G6 PE=4 SV=1 CANONICAL=E1BB89-1" }, "locus": { "chromosome": "5", "start_pos": 109938523, "end_pos": 109892455, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117756.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117756.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099206.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099206.1" } ] } }, { "isoform_ac": "E1BB89-1", "url": "https://www.uniprot.org/uniprotkb/E1BB89/entry#E1BB89-1", "sequence": { "sequence": "MVPPGPGSRGQRWWGASGVPMQEAATRGEVGMGDRARLTRDSVFFQTEGEGGGASPPAPQRMQFFGRLVNTLSSVTNLFVNPFRVKEVAVEDYHSRRRVREEGQLILFQNSSNRTWDCILVNPRNAQSGFRLFQLETEADALVNFQQYSSQLPPFYESSTHILQAEVLQQLTDLIRSHPSWSVAHLAVELGIRECFHHSHIISCANNKENEEGCTPLHLACRKGDTEVLSELVQHCRANMDVTDNSGETAFHYAVQGDSSQVLQLLGKNASGGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPGGYPIHTAMKFSQKGCAEMIVSMDSSQIHSKDPRYGASPLHWAKNAEMARLLLKRGCDVNGTSSAGNTALHVAVMRNRFDCVMVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPAFIASRISKLVTRKALLTLLRTVGADYRFPLTQGFSTEQCSAAAPSFSMERSHPPPISLNNLELQDITQISRARKPAFILSSMRDEKRTHDHLLCLDGGGVKGLVIIQLLIAIEKASGIATKDLFDWVAGTSTGGILALAILHSKSMAYMRGVYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVKKPKVMLTGTLSDRQPAELHLFRNYEAPECVREPRFSQNVNLKPPTHPSEQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQDSKVKKLSVVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGRMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEINDTVLVNALWETEVYIYEHREQFQKLVQLLLSP", "length": 866, "header": "tr|E1BB89-1|E1BB89_BOVIN Isoform 1 of 85/88 kDa calcium-independent phospholipase A2 OS=Bos taurus OX=9913 GN=PLA2G6 PE=4 SV=3 CANONICAL=E1BB89-1" }, "locus": { "chromosome": "5", "start_pos": 109944978, "end_pos": 109892455, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037697.5", "url": "https://www.ensembl.org/id/ENSBTAT00000037697.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037521.5", "url": "https://www.ensembl.org/id/ENSBTAP00000037521.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-1482788", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482788", "resource": "Reactome", "description": "Acyl chain remodelling of PC" }, { "id": "R-BTA-1482839", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482839", "resource": "Reactome", "description": "Acyl chain remodelling of PE" }, { "id": "R-BTA-2029485", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2029485", "resource": "Reactome", "description": "Role of phospholipids in phagocytosis" }, { "id": "R-BTA-6811436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811436", "resource": "Reactome", "description": "COPI-independent Golgi-to-ER retrograde traffic" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1BB89", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BB89", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ], "pmid": "" }, { "name": "pseudopodium", "id": "GO:0031143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031143", "evidence": [ { "database": "UniProtKB", "id": "E1BB89", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BB89", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "E1BB89", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ], "pmid": "" }, { "name": "phosphatidylcholine catabolic process", "id": "GO:0034638", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034638", "evidence": [ { "database": "UniProtKB", "id": "E1BB89", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ], "pmid": "" }, { "name": "antibacterial humoral response", "id": "GO:0019731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019731", "evidence": [ { "database": "UniProtKB", "id": "E1BB89", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ], "pmid": "" }, { "name": "positive regulation of insulin secretion involved in cellular response to glucose stimulus", "id": "GO:0035774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035774", "evidence": [ { "database": "UniProtKB", "id": "E1BB89", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ], "pmid": "" }, { "name": "cardiolipin acyl-chain remodeling", "id": "GO:0035965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035965", "evidence": [ { "database": "UniProtKB", "id": "E1BB89", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ], "pmid": "" }, { "name": "positive regulation of ceramide biosynthetic process", "id": "GO:2000304", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000304", "evidence": [ { "database": "UniProtKB", "id": "E1BB89", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "phosphatidylcholine lysophospholipase activity", "id": "GO:0004622", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004622", "evidence": [ { "database": "UniProtKB", "id": "E1BB89", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ], "pmid": "" }, { "name": "phospholipase A2 activity", "id": "GO:0004623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004623", "evidence": [ { "database": "UniProtKB", "id": "E1BB89", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BB89", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ], "pmid": "" }, { "name": "serine hydrolase activity", "id": "GO:0017171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017171", "evidence": [ { "database": "UniProtKB", "id": "E1BB89", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ], "pmid": "" }, { "name": "long-chain fatty acyl-CoA hydrolase activity", "id": "GO:0052816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052816", "evidence": [ { "database": "UniProtKB", "id": "E1BB89", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 269, "end_pos": 271, "annotation": "n_glycosylation_sequon" }, { "start_pos": 372, "end_pos": 374, "annotation": "n_glycosylation_sequon" }, { "start_pos": 834, "end_pos": 836, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15177", "name": "", "equation": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T0P5-1", "Q8WMP9-1", "A4IFJ5-1", "A0A3Q1LV96-1", "Q3SZ79-1", "G3X6Z1-1", "F1MNU5-1", "E1BB89-1", "A0AAA9RYE9-1", "E1BC49-1", "F1MG30-1", "F1MGH2-1", "F1MFC1-1" ], "evidence": [ { "id": "15177", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15177" } ] }, { "id": "15801", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MFC1-1", "F1MG30-1", "E1BB89-1", "E1BC49-1", "Q8WMP9-1", "P00593-1", "A4IFJ5-1", "A0A3Q1LV96-1", "E1BLF3-1", "O77834-1", "E1B9V3-1", "E1BEG8-1", "A0AAA9T9W1-1", "Q56JZ2-1", "G3N3U6-1", "Q0VC00-1", "Q1JPB9-1", "Q2KI18-1", "A0A3Q1LNM7-1", "F1MNU5-1", "F1MSG5-1", "F6RTH3-1", "A0AAA9TQC6-1", "G5E5T0-1", "A0AAA9RYE9-1", "A0ABI0P1I9-1" ], "evidence": [ { "id": "15801", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15801" } ] }, { "id": "16645", "name": "", "equation": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1A4L1-1", "A5PJT0-1", "Q3T0R7-1", "A0ABI0P2S3-1", "Q3SWX2-1", "P45478-1", "F6RWU6-1", "A0A3Q1M171-1", "F6QGE6-1", "Q1JQA0-1", "A0AAA9T509-1", "E1BB89-1", "A0AAA9SCF5-1" ], "evidence": [ { "id": "16645", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16645" } ] }, { "id": "36231", "name": "", "equation": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "P79106-1", "A0A3Q1LV96-1", "F1MNU5-1", "E1BB89-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "36231", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36231" } ] }, { "id": "38779", "name": "", "equation": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8WMP9-1", "P00593-1", "A0A3Q1LV96-1", "E1BLF3-1", "Q56JZ2-1", "E1B9V3-1", "E1BEG8-1", "A0AAA9T9W1-1", "G3N3U6-1", "F6RTH3-1", "A0AAA9TQC6-1", "A0A3Q1LNM7-1", "F1MSG5-1", "E1BB89-1", "A0AAA9RYE9-1" ], "evidence": [ { "id": "38779", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38779" } ] }, { "id": "40427", "name": "", "equation": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BC49-1", "F1MFC1-1", "F1MG30-1", "A4IFJ5-1", "P00593-1", "Q1JPB9-1", "F1MNU5-1", "E1BB89-1", "A0AAA9RYE9-1" ], "evidence": [ { "id": "40427", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40427" } ] }, { "id": "40431", "name": "", "equation": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BLF3-1", "Q56JZ2-1", "Q1JPB9-1", "E1BB89-1", "A0AAA9RYE9-1" ], "evidence": [ { "id": "40431", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40431" } ] }, { "id": "40435", "name": "", "equation": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T0P5-1", "Q8WMP9-1", "A4IFJ5-1", "A0A3Q1M5Z8-1", "A0A3Q1LV96-1", "Q3SZ79-1", "P30122-1", "Q3MHR0-1", "G3MWX2-1", "G3X6Z1-1", "A0AAA9S0E0-1", "E1BB89-1", "F1MGH2-1" ], "evidence": [ { "id": "40435", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40435" } ] }, { "id": "40463", "name": "", "equation": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BB89-1" ], "evidence": [ { "id": "40463", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40463" } ] }, { "id": "40467", "name": "", "equation": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BB89-1" ], "evidence": [ { "id": "40467", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40467" } ] }, { "id": "40479", "name": "", "equation": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P79106-1", "A0AAF7ABT5-1", "P68401-1", "Q0VC00-1", "Q28017-1", "Q29460-1", "Q3SZ16-1", "E1BB89-1" ], "evidence": [ { "id": "40479", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40479" } ] }, { "id": "40519", "name": "", "equation": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BB89-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "40519", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40519" } ] }, { "id": "40811", "name": "", "equation": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "A0A3Q1LV96-1", "E1BLF3-1", "Q56JZ2-1", "Q1JPB9-1", "F1MNU5-1", "E1BB89-1", "A0AAA9RYE9-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "40811", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40811" } ] }, { "id": "40827", "name": "", "equation": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BB89-1", "F1MGH2-1" ], "evidence": [ { "id": "40827", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40827" } ] }, { "id": "40831", "name": "", "equation": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BB89-1" ], "evidence": [ { "id": "40831", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40831" } ] }, { "id": "41067", "name": "", "equation": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BB89-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "41067", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41067" } ] }, { "id": "41223", "name": "", "equation": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8WMP9-1", "P00593-1", "A0A3Q1LV96-1", "E1BLF3-1", "O77834-1", "Q56JZ2-1", "E1B9V3-1", "E1BEG8-1", "A0AAA9T9W1-1", "G3N3U6-1", "F6RTH3-1", "A0AAA9TQC6-1", "E1BB89-1", "A0ABI0P1I9-1" ], "evidence": [ { "id": "41223", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41223" } ] }, { "id": "52812", "name": "", "equation": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BB89-1", "A0AAA9RYE9-1" ], "evidence": [ { "id": "52812", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52812" } ] }, { "id": "63256", "name": "", "equation": "1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BB89-1" ], "evidence": [ { "id": "63256", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/63256" } ] }, { "id": "63304", "name": "", "equation": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BB89-1" ], "evidence": [ { "id": "63304", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/63304" } ] }, { "id": "R-BTA-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9GL30-1", "F1MNU5-1", "F1MG30-1", "E1BB89-1", "E1BC49-1" ], "evidence": [ { "id": "R-BTA-1482856", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482856" } ] }, { "id": "R-BTA-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9GL30-1", "F1MNU5-1", "F1MG30-1", "F1MFC1-1", "E1BB89-1", "E1BC49-1" ], "evidence": [ { "id": "R-BTA-1482884", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482884" } ] }, { "id": "R-BTA-2029475", "name": "Production of AA by iPLA2 upon FCGR activation", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-428981" ], "enzyme_list": [ "E1BB89-1" ], "evidence": [ { "id": "R-BTA-2029475", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2029475" } ] }, { "id": "R-BTA-8848484", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-8848483", "R-ALL-6814303" ], "enzyme_list": [ "Q29460-1", "P68401-1", "E1BB89-1" ], "evidence": [ { "id": "R-BTA-8848484", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8848484" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-428981", "participant_name": "LPC [endoplasmic reticulum membrane]", "crossref": [ { "id": "17504", "database": "ChEBI", "url": "" }, { "id": "C04230", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-6814303", "participant_name": "fatty acid [cytosol]", "crossref": [ { "id": "35366", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-8848483", "participant_name": "2-lysophosphatidylcholine [Golgi membrane]", "crossref": [ { "id": "17504", "database": "ChEBI", "url": "" }, { "id": "C04230", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LNM7", "gene_name": "PLA2G2F", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LNM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNM7" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "A0A3Q1LNM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNM7" } ] } ] }, { "uniprot_ac": "A0A3Q1LV96", "gene_name": "PLB1", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] } ] }, { "uniprot_ac": "A0A3Q1M171", "gene_name": "ACOT11", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "A0A3Q1M171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M171" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1M171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M171" } ] } ] }, { "uniprot_ac": "A0A3Q1M5Z8", "gene_name": "LYPLA1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0A3Q1M5Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5Z8" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0A3Q1M5Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5Z8" } ] } ] }, { "uniprot_ac": "A0AAA9RYE9", "gene_name": "PNPLA8", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0AAA9RYE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYE9" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A0AAA9RYE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYE9" } ] } ] }, { "uniprot_ac": "A0AAA9S0E0", "gene_name": "LYPLA2", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0AAA9S0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0E0" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0AAA9S0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0E0" } ] } ] }, { "uniprot_ac": "A0AAA9SCF5", "gene_name": "PPT1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] }, { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] } ] }, { "uniprot_ac": "A0AAA9T0P5", "gene_name": "PNPLA6", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0AAA9T0P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0P5" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A0AAA9T0P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0P5" } ] } ] }, { "uniprot_ac": "A0AAA9T509", "gene_name": "OLAH", "activity": [ { "ec_number": "3.1.2.14", "activity": "hexadecanoyl-[ACP] + H2O = hexadecanoate + holo-[ACP] + H(+).", "evidence": [ { "id": "A0AAA9T509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T509" } ] }, { "ec_number": "3.1.2.14", "activity": "", "evidence": [ { "id": "A0AAA9T509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T509" } ] } ] }, { "uniprot_ac": "A0AAA9T9W1", "gene_name": "PLA2G2C", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0AAA9T9W1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9W1" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "A0AAA9T9W1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9W1" } ] } ] }, { "uniprot_ac": "A0AAA9TQC6", "gene_name": "LOC613966", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0AAA9TQC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQC6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "A0AAA9TQC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQC6" } ] } ] }, { "uniprot_ac": "A0AAF7ABT5", "gene_name": "PAFAH1B3", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "A0AAF7ABT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "A0AAF7ABT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5" } ] } ] }, { "uniprot_ac": "A0ABI0P1I9", "gene_name": "", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "A0ABI0P1I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1I9" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "A0ABI0P1I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1I9" } ] } ] }, { "uniprot_ac": "A0ABI0P2S3", "gene_name": "THEM4", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "A0ABI0P2S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2S3" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "A0ABI0P2S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2S3" } ] } ] }, { "uniprot_ac": "A1A4L1", "gene_name": "THEM4", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "A1A4L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4L1" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "A1A4L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4L1" } ] } ] }, { "uniprot_ac": "A4IFJ5", "gene_name": "PLA2G4A", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A4IFJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFJ5" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A4IFJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFJ5" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "A4IFJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFJ5" } ] } ] }, { "uniprot_ac": "A5PJT0", "gene_name": "MBLAC2", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "A5PJT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJT0" } ] }, { "ec_number": "3.5.2.6", "activity": "a beta-lactam + H2O = a substituted beta-amino acid.", "evidence": [ { "id": "A5PJT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJT0" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "A5PJT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJT0" } ] } ] }, { "uniprot_ac": "E1B9V3", "gene_name": "LOC112443425", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1B9V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9V3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "E1B9V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9V3" } ] } ] }, { "uniprot_ac": "E1BB89", "gene_name": "PLA2G6", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] } ] }, { "uniprot_ac": "E1BC49", "gene_name": "PLA2G4B", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1BC49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC49" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "E1BC49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC49" } ] } ] }, { "uniprot_ac": "E1BEG8", "gene_name": "PLA2G5", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1BEG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEG8" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "E1BEG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEG8" } ] } ] }, { "uniprot_ac": "E1BLF3", "gene_name": "LOC615045", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1BLF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLF3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "E1BLF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLF3" } ] } ] }, { "uniprot_ac": "F1MFC1", "gene_name": "PLA2G4E", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "F1MFC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFC1" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "F1MFC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFC1" } ] } ] }, { "uniprot_ac": "F1MG30", "gene_name": "PLA2G4D", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "F1MG30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG30" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "F1MG30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG30" } ] } ] }, { "uniprot_ac": "F1MGH2", "gene_name": "ASPG", "activity": [ { "ec_number": "3.5.1.1", "activity": "L-asparagine + H2O = L-aspartate + NH4(+).", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] } ] }, { "uniprot_ac": "F1MNU5", "gene_name": "PLA2G4F", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "F1MNU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU5" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "F1MNU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU5" } ] } ] }, { "uniprot_ac": "F1MSG5", "gene_name": "PLA2G2E", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "F1MSG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG5" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "F1MSG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG5" } ] } ] }, { "uniprot_ac": "F6QGE6", "gene_name": "ACOT13", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "F6QGE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QGE6" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "F6QGE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QGE6" } ] } ] }, { "uniprot_ac": "F6RTH3", "gene_name": "PLA2G2D4", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "F6RTH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RTH3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "F6RTH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RTH3" } ] } ] }, { "uniprot_ac": "F6RWU6", "gene_name": "ACOT8", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.3", "activity": "succinyl-CoA + H2O = succinate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.11", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.5", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.27", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] } ] }, { "uniprot_ac": "G3MWX2", "gene_name": "", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "G3MWX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWX2" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "G3MWX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWX2" } ] } ] }, { "uniprot_ac": "G3N3U6", "gene_name": "PLA2G2D3", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "G3N3U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3U6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "G3N3U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3U6" } ] } ] }, { "uniprot_ac": "G3X6Z1", "gene_name": "PNPLA7", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "G3X6Z1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Z1" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "G3X6Z1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Z1" } ] } ] }, { "uniprot_ac": "G5E5T0", "gene_name": "PNPLA2", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "G5E5T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5T0" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "G5E5T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5T0" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "G5E5T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5T0" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "G5E5T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5T0" } ] } ] }, { "uniprot_ac": "O77834", "gene_name": "PRDX6", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "O77834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77834" } ] }, { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O77834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77834" } ] }, { "ec_number": "2.3.1.23", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA.", "evidence": [ { "id": "O77834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77834" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "O77834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77834" } ] } ] }, { "uniprot_ac": "P00593", "gene_name": "PLA2G1B", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P00593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00593" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P00593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00593" } ] } ] }, { "uniprot_ac": "P30122", "gene_name": "CEL", "activity": [ { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = cholesterol + a fatty acid + H(+).", "evidence": [ { "id": "P30122", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P30122" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P30122", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P30122" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = an aliphatic alcohol + acetate + H(+).", "evidence": [ { "id": "P30122", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P30122" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": "P30122", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P30122" } ] }, { "ec_number": "3.1.1.6", "activity": "", "evidence": [ { "id": "P30122", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P30122" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P30122", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P30122" } ] } ] }, { "uniprot_ac": "P45478", "gene_name": "PPT1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] }, { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] } ] }, { "uniprot_ac": "P68401", "gene_name": "PAFAH1B2P68402", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P68401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68401" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "P68401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68401" } ] } ] }, { "uniprot_ac": "P79106", "gene_name": "PAFAH2", "activity": [ { "ec_number": "2.3.1.149", "activity": "a 1-organyl-2-lyso-sn-glycero-3-phospholipid + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine = a 1-organyl-2-acetyl-sn-glycero-3-phospholipid + a 1-O-alkyl-sn-glycero-3-phosphocholine.", "evidence": [ { "id": "P79106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79106" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P79106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79106" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "P79106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79106" } ] } ] }, { "uniprot_ac": "Q0VC00", "gene_name": "ABHD3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q0VC00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC00" } ] }, { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q0VC00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC00" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q0VC00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC00" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q0VC00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC00" } ] } ] }, { "uniprot_ac": "Q1JPB9", "gene_name": "PLA2G3", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q1JPB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPB9" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q1JPB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPB9" } ] } ] }, { "uniprot_ac": "Q1JQA0", "gene_name": "PPT2", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "Q1JQA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA0" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q1JQA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA0" } ] } ] }, { "uniprot_ac": "Q28017", "gene_name": "PLA2G7", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q28017", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28017" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q28017", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28017" } ] } ] }, { "uniprot_ac": "Q29460", "gene_name": "PAFAH1B3", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q29460", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29460" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q29460", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29460" } ] } ] }, { "uniprot_ac": "Q2KI18", "gene_name": "PNPLA2", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q2KI18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI18" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q2KI18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI18" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q2KI18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI18" } ] } ] }, { "uniprot_ac": "Q3MHR0", "gene_name": "LYPLA1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "Q3MHR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHR0" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q3MHR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHR0" } ] } ] }, { "uniprot_ac": "Q3SWX2", "gene_name": "ACOT9", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q3SWX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWX2" } ] }, { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "Q3SWX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWX2" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q3SWX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWX2" } ] } ] }, { "uniprot_ac": "Q3SZ16", "gene_name": "IAH1", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q3SZ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q3SZ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q3SZ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ16" } ] } ] }, { "uniprot_ac": "Q3SZ79", "gene_name": "LIPC", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q3SZ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ79" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q3SZ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ79" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q3SZ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ79" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q3SZ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ79" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q3SZ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ79" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q3SZ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ79" } ] } ] }, { "uniprot_ac": "Q3T0R7", "gene_name": "ACAA2", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q3T0R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R7" } ] }, { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "Q3T0R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R7" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "Q3T0R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R7" } ] }, { "ec_number": "2.3.1.16", "activity": "an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "Q3T0R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R7" } ] }, { "ec_number": "2.3.1.9", "activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.", "evidence": [ { "id": "Q3T0R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R7" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "Q3T0R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R7" } ] } ] }, { "uniprot_ac": "Q56JZ2", "gene_name": "PLA2G2A", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q56JZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JZ2" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q56JZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JZ2" } ] } ] }, { "uniprot_ac": "Q8WMP9", "gene_name": "PLA2G15", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8WMP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8WMP9" } ] }, { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8WMP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8WMP9" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q8WMP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8WMP9" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8WMP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8WMP9" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q8WMP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8WMP9" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8WMP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8WMP9" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q8WMP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8WMP9" } ] } ] }, { "uniprot_ac": "Q9GL30", "gene_name": "PLBD1", "activity": [ { "ec_number": "3.4.11.-", "activity": "", "evidence": [ { "id": "Q9GL30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GL30" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" }, { "id": "PS51635", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51635" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PNPLA", "eco_id": "ECO_0000259", "start_pos": 541, "end_pos": 725, "start_aa": "Leu", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.2.2", "ec_name": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "3.1.2.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2" }, { "id": "3.1.2.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.2.2" } ] }, { "ec_number": "3.1.1.4", "ec_name": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "3.1.1.4", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4" }, { "id": "3.1.1.4", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.4" } ] }, { "ec_number": "3.1.1.5", "ec_name": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "3.1.1.5", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5" }, { "id": "3.1.1.5", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.5" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 }, { "start_pos": 113, "end_pos": 115 }, { "start_pos": 269, "end_pos": 271 }, { "start_pos": 372, "end_pos": 374 }, { "start_pos": 834, "end_pos": 836 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", 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"url": "https://www.uniprot.org/uniprotkb/E1BAA5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEVGRVAVSDPGSRLLPGGFWAAVAVWVERPQVANKRLCGVRLEARRSVSLPQIGHTHPGPSAGPEPERLAEAGGCGPDAGPGPVWRSLDAGPGPGPTASPDQGRQEAQGRRQPEEEPGEAAAAAATQLSGTPGQPGKAAAREGDLPAADLGALWDVFAQSLAGDNREVLAFLTRSGAESPPEGRRELDLVLRTVIPKTNLHCPLRGPRREMVLQDVLSGAVTFLPLEEDDEGNLKVKMSNVYQIQLSHSEGEWFISVLIFCPERWHSDGTVYPKPTWLGEELLARLARWCVESRQSGFKSTLSLISVMKYSAAYQALKEKYKDMVKVWPEVTDPEKFVYEDVAIAAYLLILWEEERAERGETARQSFVDLGCGNGLLVHILSSEGHPGRGIDVRRRKIWDMYGPQTRLEESAITPNDKSLFPDVDWLIGNHSDELTPWIPVIAARSSYDCRFFVLPCCFFDFIGKFQRTQSSKTQYRGYLDFITEVGSACGFHVEEDCLRIPSTKRVCLIGKSRTYPPTREASVDEERTRYINSRRGCPGSPCSGGPALPPPGAAPSSAPGPKGHGALDARPAHTAEAGAGQQGARAPAEGLWMSGFQPREKAERLRNCAALPREFVDRVVLQVAHLLLGRSPAGGSAQAWNRGGSLSLAEVAGELDRETLQRLKRECGGLQTLLRNSPQVFQVVHGRVRIRDWREERPRKKEEPEAKRRPSSDTFKTRICWFFAHHPDGCVLPADCCPFAHGPGELRPAPRTKKKKPAL", "length": 762, "header": "tr|E1BAA5-1|E1BAA5_BOVIN Isoform 1 of tRNA (uracil-O(2)-)-methyltransferase OS=Bos taurus OX=9913 GN=TRMT44 PE=3 SV=3 CANONICAL=E1BAA5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFZ8-1", "url": "https://www.uniprot.org/uniprotkb/E1BAA5/entry#A0AAA9SFZ8-1", "sequence": { "sequence": "MAEVGRVAVSDPGSRLLPGGFWAAVAVWVERPQVANKRLCGVRLEARRSVSLPQIGHTHPGPSAGPEPERLAEAGGCGPDAGPGPVWRSLDAGPGPGPTASPDQGRQEAQGRRQPEEEPGEAAAAAATQLSGTPGQPGKAAAREGDLPAADLGALWDVFAQSLAGDNREVLAFLTRSGAESPPEGRRELDLVLRTVIPKTNLHCPLRGPRREMVLQDVLSGAVTFLPLEEDDEGNLKVKMSNVYQIQLSHSEGEWFISVLIFCPERWHSDGTVYPKPTWLGEELLARLARWCVESRQSGFKSTLSLISVMKYSAAYQALKEKYKDMVKVWPEVTDPEKFVYEDVAIAAYLLILWEEERAERGETARQSFVDLGCGNGLLVHILSSEGHPGRGIDVRRRKIWDMYGPQTRLEESAITPNDKSLFPDVDWLIGNHSDELTPWIPVIAARSSYDCRFFVLPCCFFDFIGKFQRTQSSKTQYRGYLDFITEVGSACGFHVEEDCLRIPSTKRVCLIGKSRTYPPTREASVDEERTRYINSRRGCPGSPCSGGPALPPPGAAPSSAPGPKGHGALDARPAHTAEAGAGQQGARAPAEGLWMSGFQPREKAERLRNCAALPREFVDRVVLQVAHLLLGRSPAGGSAQAWNRGVVHGRVRIRDWREERPRKKEEPEAKRRPSSDTFKTRICWFFAHHPDGCVLPADCCPFAHGPGELRPAPRTKKKKPAL", "length": 723, "header": "tr|A0AAA9SFZ8-1|E1BAA5_BOVIN Computationally mapped isoform of tRNA (uracil-O(2)-)-methyltransferase OS=Bos taurus OX=9913 GN=TRMT44 PE=3 SV=1 CANONICAL=E1BAA5-1" }, "locus": { "chromosome": "6", "start_pos": 114743685, "end_pos": 114718739, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127395.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127395.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082800.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082800.1" } ] } }, { "isoform_ac": "E1BAA5-1", "url": "https://www.uniprot.org/uniprotkb/E1BAA5/entry#E1BAA5-1", "sequence": { "sequence": "MAEVGRVAVSDPGSRLLPGGFWAAVAVWVERPQVANKRLCGVRLEARRSVSLPQIGHTHPGPSAGPEPERLAEAGGCGPDAGPGPVWRSLDAGPGPGPTASPDQGRQEAQGRRQPEEEPGEAAAAAATQLSGTPGQPGKAAAREGDLPAADLGALWDVFAQSLAGDNREVLAFLTRSGAESPPEGRRELDLVLRTVIPKTNLHCPLRGPRREMVLQDVLSGAVTFLPLEEDDEGNLKVKMSNVYQIQLSHSEGEWFISVLIFCPERWHSDGTVYPKPTWLGEELLARLARWCVESRQSGFKSTLSLISVMKYSAAYQALKEKYKDMVKVWPEVTDPEKFVYEDVAIAAYLLILWEEERAERGETARQSFVDLGCGNGLLVHILSSEGHPGRGIDVRRRKIWDMYGPQTRLEESAITPNDKSLFPDVDWLIGNHSDELTPWIPVIAARSSYDCRFFVLPCCFFDFIGKFQRTQSSKTQYRGYLDFITEVGSACGFHVEEDCLRIPSTKRVCLIGKSRTYPPTREASVDEERTRYINSRRGCPGSPCSGGPALPPPGAAPSSAPGPKGHGALDARPAHTAEAGAGQQGARAPAEGLWMSGFQPREKAERLRNCAALPREFVDRVVLQVAHLLLGRSPAGGSAQAWNRGGSLSLAEVAGELDRETLQRLKRECGGLQTLLRNSPQVFQVVHGRVRIRDWREERPRKKEEPEAKRRPSSDTFKTRICWFFAHHPDGCVLPADCCPFAHGPGELRPAPRTKKKKPAL", "length": 762, "header": "tr|E1BAA5-1|E1BAA5_BOVIN Isoform 1 of tRNA (uracil-O(2)-)-methyltransferase OS=Bos taurus OX=9913 GN=TRMT44 PE=3 SV=3 CANONICAL=E1BAA5-1" }, "locus": { "chromosome": "6", "start_pos": 114743685, "end_pos": 114718739, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006298.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006298.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006298.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006298.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 99, "start_aa": "Thr", "end_pos": 99, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr99", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:513470", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513470", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YXQ6-1", "protein_name": "tRNA (uracil-O(2)-)-methyltransferase", "gene_name": "TRMT44", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGLLGTAAVRGGGAVLPRGFWAAVRVWLEKPQVANRRLCGAAIEAEGTVLPGEDGDASPHLGSGEESAGAAELGRLWREVREELLPFLAAGPGRELRAVLRALLPRVRPAGPPAPPVKELVVQDVCNGTVTFLPLEENSEGKYQIKKCNIYQIQLTHIGDEEWSVSIIAPSSEDWFSDGITYPKLSWLGDVLLSKLAKWSVEQKCSEFRSTLSLIPVAKYSKIYQDLKEKYKEMVKVWPEVTDPEKFVYEDVAIATYLLVLWEEERKEKGLANKQSFVDLGCGNGLLVHILSNEGHLGRGIDVRRRKIWDMYGPETHLEESSIVPGDSHLFPDTDWLIGNHSDELTPWIPVIAARSSYSCRYFVLPCCFFDFHGKYSRRQSKKTQYREYLDFVAEVGCVCGFNVEEDCLRIPSTKRVCLIGKNRTYPPMERSLIDEQITQFIHNRQTCAVVARDREDGFNHNSHSDLCKGVSSELPENMMEMASGIWMPGFQPREKVEQTRNCAALPRDFVDGVVLNVANLLLNAVPAKSCSNSHGGNKDTWNPGESLSLKEVAEHLNKETLKRLKSEYGGLQTLLKNNHQVFQVLDGRVHIRDWRKEKPSRKTKPEVKRCLSAEAFKTRLCWFFIHHPDGCSLPSESCPYAHGPEELRQSETIKKKKHIW", "length": 661 }, "evidence": [ { "id": "E1BAA5", "url": "https://omabrowser.org/oma/group/E1BAA5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZS79-1", "protein_name": "tRNA (uracil-O(2)-)-methyltransferase", "gene_name": "Trmt44", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLFRVASSQCAESADMEELRRVPLDDPDSLLPGGFWAAVTVWLERPQVANKRLCGARIEARGRTLRPSAQAECGPRQGQGHGLEREPGQGSRADREGTAPAADLDLLWNRVSQSLVHSNPEILTFYGPSLGSPPEAAQELDLVLRTVIPKASPHFPFTEPKKELVVQDVSSGSVTFLPLEEDNEENLEVKMSNVYQLRLHHSEGEWFISVLIFCPERWHSDGVVYPKPTWLAEELLSKLARWAVENRKSEFKSTLSLVSVLRYGRMYQELKEKYRDMVKVWPEVTDPEKFVYEDVAIATYLLILWEEERAEKGITTKQSFVDLGCGNGLLVHILSNEGHPGRGIDVRRRKIWDMYGPQTQLEEGSITPSDKTLFPGVDWLIGNHSDELTPWIPVIAARSSYTCRFFVLPCCFFDFVGRYRRRQSKKTQYREYLDFVLEVGLSCGFHVQEDCLRIPSTKRVCLIGKSRTYLPSAEVWMDEQRTRYLHSRQGLPQSLPGGGHAPSVPQIAAHDDDAGHQDSHRTFDAGAECMPEGLAAERGTGAPATGLWVPGFCPREKAERVRNCAALPRDFIDQVVLQVANLLLDGKRFNTGNSEAGSLKTWNGGGSLSLAEVAAELNSETLQQLKRECGGLQTLLRNSHQVFEVLNGRVHIRDWRRELQREKPPEGKRSLSAEVFKTRICWFFTHHPDGCVLPAACCPFAHGLEELRPSQTLKKQRQAP", "length": 720 }, "evidence": [ { "id": "E1BAA5", "url": "https://omabrowser.org/oma/group/E1BAA5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9QD66-1", "protein_name": "tRNA (uracil-O(2)-)-methyltransferase", "gene_name": "trmt44", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTDKCSTENFWSAADVWINKPHVVNKRLSGVTETKYRDVDTSGLNQVLSTLLGSSIEISHICQFLRVDNANKELDTAGRWCVGVRTIIPKVTKTAECNVMYKDVIVKDIVGHAVTFIPFEEIAGHVTLKSSNIYQIDLKPDEGMFSLHVLRPEQWYSDGIAYPKLSWLRTELLPKLSRWSLESKTCVFKSTLSLIPVDKYSMLYQQLKLKYKDLVKVWPEVTDPQKFVFEDVAIATYLLVLWAEERAEKGTTTKQSFVDLGCGNGLLVHILNNEGHPGKGIDIRKRKIWDLYGPGTHLEENAITPSNGFLFPTTDWLIGNHSDELTPWIPVIAARSSYSCRFFVLPCCFFDFCGKYQRRQCTKSQYKEYIDFITDVSTVCGFYAEEDCLRIPSTKRVCIIGKGRRYRQAEEALVEESRSNYIKEREAMLTSSRDSLNPSQCGHDDLDHNDTELNISTPANDWVSGFQLREKTEAVRNCAALPRNFVDAVVLKVAKALLTLTESSNCGDTWNKGGSLSVSEVVDLLDQSTLQTLKKECGGLQTLLKNNHQVFRVEGGRVFIRDWRMHTPAQSSKVTPKRKPTPSGALKTRLCWFFTHHPHGCPLPCEDCAFAHGETDLRPSLKPPK", "length": 625 }, "evidence": [ { "id": "E1BAA5", "url": "https://omabrowser.org/oma/group/E1BAA5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8IYL2-1", "protein_name": "Probable tRNA (uracil-O(2)-)-methyltransferase", "gene_name": "TRMT44", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEVGRTGISYPGALLPQGFWAAVEVWLERPQVANKRLCGARLEARWSAALPCAEARGPGTSAGSEQKERGPGPGQGSPGGGPGPRSLSGPEQGTACCELEEAQGQCQQEEAQREAASVPLRDSGHPGHAEGREGDFPAADLDSLWEDFSQSLARGNSELLAFLTSSGAGSQPEAQRELDVVLRTVIPKTSPHCPLTTPRREIVVQDVLNGTITFLPLEEDDEGNLKVKMSNVYQIQLSHSKEEWFISVLIFCPERWHSDGIVYPKPTWLGEELLAKLAKWSVENKKSDFKSTLSLISIMKYSKAYQELKEKYKEMVKVWPEVTDPEKFVYEDVAIAAYLLILWEEERAERRLTARQSFVDLGCGNGLLVHILSSEGHPGRGIDVRRRKIWDMYGPQTQLEEDAITPNDKTLFPDVDWLIGNHSDELTPWIPVIAARSSYNCRFFVLPCCFFDFIGRYSRRQSKKTQYREYLDFIKEVGFTCGFHVDEDCLRIPSTKRVCLVGKSRTYPSSREASVDEKRTQYIKSRRGCPVSPPGWELSPSPRWVAAGSAGHCDGQQALDARVGCVTRAWAAEHGAGPQAEGPWLPGFHPREKAERVRNCAALPRDFIDQVVLQVANLLLGGKQLNTRSSRNGSLKTWNGGESLSLAEVANELDTETLRRLKRECGGLQTLLRNSHQVFQVVNGRVHIRDWREETLWKTKQPEAKQRLLSEACKTRLCWFFMHHPDGCALSTDCCPFAHGPAELRPPRTTPRKKIS", "length": 757 }, "evidence": [ { "id": "E1BAA5", "url": "https://omabrowser.org/oma/group/E1BAA5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D2Q2-1", "protein_name": "Probable tRNA (uracil-O(2)-)-methyltransferase", "gene_name": "Trmt44", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEELGRVRLSDPDALLPAGFWAAVTVWLERPQVANKRLCGARMEARGRTLRSHAQAECGPRQGQGHGLEREPGQASPKGEPESGPRASREGTAPAADLNSLWDRVSQSLVHANPEMLAFLCGPSLGPQPEAAQELDLILRTVIPKASPHSPLTEPKKELVVQDVSSGSVTFLPLEEDNEGNLEVKTSNVYQLHLHHNEGEWFISVLIFCPERWHSDGVVYPKPAWLGEELLSKLARWAVENRKSEFKSTLSLVSILRYSRMYQELKEKYRDMVKVWPEVTDPEKFVYEDVAIATYLLILWEEERAEKGVTTKQSFVDLGCGNGLLVHILSNEGHPGRGIDIRRRKIWDMYGPQTQLEEGSITPSDETLFPGVDWLIGNHSDELTPWIPVIAARSSYTCRFFVLPCCFFDFVGRYQRQQSRKTQYREYLDFVLEVGLSCGFHVQEDCLRIPSTKRVCLIGKSRTYPPSAEVWMDEQRTRYLHSRQGHPQSRPGGAHAPSAPQTAAHDAGLQDSCRTVNAGSECVLEGLAAERGAGAPAPGLWVPGFCPREKAERVRNCAALPRDFVDQVVLQVANLLLDRKKFNTGNSEARSLKPWNGGGSLSLAEVAAELNSETLQRLKRECGGLQTLLKNSHQVFEVLNGRVHIRDWRQELQRGKPPEAKQNLSAAVFKTRICWFFAHHPDGCVLPAAQCPFAHGPEELRLSQTLKKQRQAP", "length": 713 }, "evidence": [ { "id": "E1BAA5", "url": "https://omabrowser.org/oma/group/E1BAA5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VHB9-1", "protein_name": "Probable tRNA (uracil-O(2)-)-methyltransferase", "gene_name": "trmt44", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAAVEEAQFWQAIGILIKNYHALNKKIFEVVITQVTKQQNGRVCESSAEELAMSLKEDPSQRTCTGFTIGFKLLSKKLAENILGTGIVDFENCLYECQFASDSIEGFSVGLLGGEFKLKSKSNTNWLEFVLRPKLLSWSQSKQDEAKVKSLGLVNVEKYNDLYKELKQRHSQRLLEHWKTAQESTDPLKFIYEDLAIAAYLIVLWSQTQSEPTAFADLGCGNGLLVHVLNAEGYKGYGYDIRKRKLWSLYPPDTQRSLIEKAVEPNSFRLDFPGVDWLIGNHSDELSPWLPVLAGRLNINYFLLPCCPFELSGAKFRRRNTKISAYQDFFQYVTQVSHECGYEILQDRLKIPSTKRLALLGIKRKASKAIEDLEYFVQEELRKYKTGDAKIKLREKEESVRNCTQVDKTIIDGLVFKIFKLILDSNEDKWSGRLPMREIAQALTKEELSGIKSECGGIKTLLRNKHEVFEFCGGDLIGIRTPKPTATLPKSHLTIKKRSCFFKLHHPLGCPLDDAECSFIH", "length": 521 }, "evidence": [ { "id": "E1BAA5", "url": "https://omabrowser.org/oma/group/E1BAA5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BAA5", "url": "https://www.uniprot.org/uniprotkb/E1BAA5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BAA5", "url": "https://www.uniprot.org/uniprotkb/E1BAA5" } ], "pmid": "" }, { "name": "tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity", "id": "GO:0141101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141101", "evidence": [ { "database": "UniProtKB", "id": "E1BAA5", "url": "https://www.uniprot.org/uniprotkb/E1BAA5" } ], "pmid": "" }, { "name": "tRNA (uridine) methyltransferase activity", "id": "GO:0016300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016300", "evidence": [ { "database": "UniProtKB", "id": "E1BAA5", "url": "https://www.uniprot.org/uniprotkb/E1BAA5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "tRNA methylation", "id": "GO:0030488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030488", "evidence": [ { "database": "UniProtKB", "id": "E1BAA5", "url": "https://www.uniprot.org/uniprotkb/E1BAA5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 432, "end_pos": 434, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "43100", "name": "", "equation": "uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BAA5-1" ], "evidence": [ { "id": "43100", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43100" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "E1BAA5", "gene_name": "TRMT44", "activity": [ { "ec_number": "2.1.1.211", "activity": "uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "E1BAA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAA5" } ] }, { "ec_number": "2.1.1.211", "activity": "", "evidence": [ { "id": "E1BAA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAA5" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAA5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 762, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAA5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAA5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAA5" }, { "id": "PS50103", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50103" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C3H1-type", "eco_id": "ECO_0000259", "start_pos": 717, "end_pos": 747, "start_aa": "Thr", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.1.1.211", "ec_name": "uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "2.1.1.211", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.211" }, { "id": "2.1.1.211", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.211" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 99 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 432, "end_pos": 434 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B8N4-1", "uniprot_ac": "E1B8N4", "uniprot_id": "E1B8N4_BOVIN", "mass": { "chemical_mass": 65887.0, "monoisotopic_mass": 65887.0 }, "refseq": { "ac": "NP_001179499", "name": "trehalase precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179499" }, "gene_names": [ { "name": "TREH", "type": "recommended", "evidence": [ { "id": "E1B8N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8N4" } ] }, { "name": "TREH", "type": "synonym", "evidence": [ { "id": "NP_001179499", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179499" } ] } ], "protein_names": [ { "name": "Trehalase", "type": "recommended", "evidence": [ { "id": "E1B8N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8N4/entry#names_and_taxonomy" } ] }, { "name": "3.2.1.28", "type": "synonym", "evidence": [ { "id": "E1B8N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8N4/entry#names_and_taxonomy" } ] }, { "name": "Alpha-trehalose glucohydrolase", "type": "synonym", "evidence": [ { "id": "E1B8N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8N4/entry#names_and_taxonomy" } ] }, { "name": "trehalase (brush-border membrane glycoprotein)", "type": "synonym", "evidence": [ { "id": "NP_001179499", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179499" } ] }, { "name": "trehalase precursor", "type": "synonym", "evidence": [ { "id": "NP_001179499", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179499" } ] } ], "function": [ { "annotation": "Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.", "evidence": [ { "database": "UniProtKB", "id": "E1B8N4", "url": "https://www.uniprot.org/uniprotkb/E1B8N4#function" }, { "database": "UniProtKB", "id": "ARBA00057606", "url": "https://www.uniprot.org/uniprotkb/ARBA00057606#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8N4", "url": "https://www.uniprot.org/uniprotkb/E1B8N4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TREH", "url": "https://www.uniprot.org/uniprotkb/E1B8N4", "locus": { "chromosome": "15", "start_pos": 29310851, "end_pos": 29323109, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016202", "url": "https://www.ensembl.org/id/ENSBTAG00000016202" } ] } } ], "crossref": [ { "id": "E1B8N4", "url": "https://alphafold.ebi.ac.uk/entry/E1B8N4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016202", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016202", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "522889", "url": "https://www.ncbi.nlm.nih.gov/gene/522889", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001661", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001661", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008928", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008928", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018232", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018232", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054491", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054491", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522889", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522889", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RYWDASD", "url": "https://omabrowser.org/oma/group/RYWDASD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8N4", "url": "https://www.orthodb.org/?gene=E1B8N4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23403", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23403", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23403:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23403:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01204", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01204", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22422", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22422", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179499", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "32675", "url": "https://www.rhea-db.org/rhea/32675", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SP15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP15-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8N4", "url": "https://www.uniprot.org/uniprotkb/E1B8N4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8N4-1", "url": "https://www.uniprot.org/uniprotkb/E1B8N4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQGRTWGLRLLLLLGLRLGSQEALPPPCGSQIYCHGELLRQVQMAKLYQDDKQFVDMPLSSAPDQVLRHFRELAQTHNLSIPRQELQMFVQEHFRAVGQELQPWTPEDWRDSPQFLQKILDPRLRAWAGQLHQLWKKLGKKVKPEVLSHPEQFSLIYSRHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMPETVKGMLQNFLDLVQTYGHVPNGARVYYLQRSQPPLLTLMMDRYVAHTNDTTFLRDHIETLASELDFWTKNRSISVSSGGKSYILNHYEVPYGGPRPESYSKDAELAATLLEGNRDTLLAELKASAESGWDFSSRWLVGGPNPSSLSSIRTSKLVPVDLNAFLCQAEGLMSNFYSRLGNDSEAAKYRNLRAERMAALKDVLWDEDKGVWFDYDLENEKKNLEFYPSNFAPLWAGCFSDPDDVDKALKYLEDSRILTYQYGIPTSLQKTGQQWDFPNAWAPLQDLVIRGLAKSPSAKAQEVAFQLAQNWIRTNFDVYSKKSAMYEKYDISNGGQPGGGGEYEVQEGFGWTNGVALMLLDRYGDRLSSGAQTALLAPHCLAAALLLSLLPQ", "length": 579, "header": "tr|E1B8N4-1|E1B8N4_BOVIN Isoform 1 of Trehalase OS=Bos taurus OX=9913 GN=TREH PE=3 SV=3 CANONICAL=E1B8N4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SP15-1", "url": "https://www.uniprot.org/uniprotkb/E1B8N4/entry#A0AAA9SP15-1", "sequence": { "sequence": "MQGRTWGLRLLLLLGLRLGSQEALPPPCGSQIYCHGELLRQVQMAKLYQDDKQFVDMPLSSAPDQVLRHFRELAQTHNLSIPRQELQMFVQEHFRAVGQELQPWTPEDWRDSPQFLQKILDPRLRAWAGQLHQLWKKLGKKVKPEVLSHPEQFSLIYSRHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMPETVKGMLQNFLDLVQTYGHVPNGARVYYLQRSQPPLLTLMMDRYVAHTNDTTFLRDHIETLASELDFWTKNRSISVSSGGKSYILNHYEVPYGGPSSLSSIRTSKLVPVDLNAFLCQAEGLMSNFYSRLGNDSEAAKYRNLRAERMAALKDVLWDEDKGVWFDYDLENEKKNLEFYPSNFAPLWAGCFSDPDDVDKALKYLEDSRILTYQYGIPTSLQKTGQQWDFPNAWAPLQDLVIRGLAKSPSAKAQEVAFQLAQNWIRTNFDVYSKKSAMYEKYDISNGGQPGGGGEYEVQEGFGWTNGVALMLLDRYGDRLSSGAQTALLAPHCLAAALLLSLLPQ", "length": 531, "header": "tr|A0AAA9SP15-1|E1B8N4_BOVIN Computationally mapped isoform of Trehalase OS=Bos taurus OX=9913 GN=TREH PE=3 SV=1 CANONICAL=E1B8N4-1" }, "locus": { "chromosome": "15", "start_pos": 29323043, "end_pos": 29310921, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134975.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134975.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085704.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085704.1" } ] } }, { "isoform_ac": "A0AAA9TMM3-1", "url": "https://www.uniprot.org/uniprotkb/E1B8N4/entry#A0AAA9TMM3-1", "sequence": { "sequence": "MQGRTWGLRLLLLLGLRLGSQEALPPPCGSQIYCHGELLRQVQMAKLYQDDKQFVDMPLSSAPDQVLRHFRELAQTHNLSIPRQELQMFVQEHFRAVGQELQPWTPEDWRDSPQFLQKILDPRLRAWAGQLHQLWKKLGKKVKPEVLSHPEQFSLIYSRHPFIVPGGRFVEFYYWYGHVPNGARVYYLQRSQPPLLTLMMDRYVAHTNDTTFLRDHIETLASELDFWTKNRSISVSSGGKSYILNHYEVPYGGPRPESYSKDAELAATLLEGNRDTLLAELKASAESGWDFSSRWLVGGPNPSSLSSIRTSKLVPVDLNAFLCQAEGLMSNFYSRLGNDSEAAKYRNLRAERMAALKDVLWDEDKGVWFDYDLENEKKNLEFYPSNFAPLWAGCFSDPDDVDKALKYLEDSRILTYQYGIPTSLQKTGQQWDFPNAWAPLQDLVIRGLAKSPSAKAQEVAFQLAQNWIRTNFDVYSKKSAMYEKYDISNGGQPGGGGEYEVQEGFGWTNGVALMLLDRYGDRLSSGAQTALLAPHCLAAALLLSLLPQ", "length": 548, "header": "tr|A0AAA9TMM3-1|E1B8N4_BOVIN Computationally mapped isoform of Trehalase OS=Bos taurus OX=9913 GN=TREH PE=3 SV=1 CANONICAL=E1B8N4-1" }, "locus": { "chromosome": "15", "start_pos": 29323043, "end_pos": 29310921, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121098.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121098.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097587.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097587.1" } ] } }, { "isoform_ac": "E1B8N4-1", "url": "https://www.uniprot.org/uniprotkb/E1B8N4/entry#E1B8N4-1", "sequence": { "sequence": "MQGRTWGLRLLLLLGLRLGSQEALPPPCGSQIYCHGELLRQVQMAKLYQDDKQFVDMPLSSAPDQVLRHFRELAQTHNLSIPRQELQMFVQEHFRAVGQELQPWTPEDWRDSPQFLQKILDPRLRAWAGQLHQLWKKLGKKVKPEVLSHPEQFSLIYSRHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMPETVKGMLQNFLDLVQTYGHVPNGARVYYLQRSQPPLLTLMMDRYVAHTNDTTFLRDHIETLASELDFWTKNRSISVSSGGKSYILNHYEVPYGGPRPESYSKDAELAATLLEGNRDTLLAELKASAESGWDFSSRWLVGGPNPSSLSSIRTSKLVPVDLNAFLCQAEGLMSNFYSRLGNDSEAAKYRNLRAERMAALKDVLWDEDKGVWFDYDLENEKKNLEFYPSNFAPLWAGCFSDPDDVDKALKYLEDSRILTYQYGIPTSLQKTGQQWDFPNAWAPLQDLVIRGLAKSPSAKAQEVAFQLAQNWIRTNFDVYSKKSAMYEKYDISNGGQPGGGGEYEVQEGFGWTNGVALMLLDRYGDRLSSGAQTALLAPHCLAAALLLSLLPQ", "length": 579, "header": "tr|E1B8N4-1|E1B8N4_BOVIN Isoform 1 of Trehalase OS=Bos taurus OX=9913 GN=TREH PE=3 SV=3 CANONICAL=E1B8N4-1" }, "locus": { "chromosome": "15", "start_pos": 29323043, "end_pos": 29310921, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021565.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021565.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021565.5", "url": "https://www.ensembl.org/id/ENSBTAP00000021565.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:522889", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522889", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7FTW6-1", "protein_name": "Trehalase", "gene_name": "Treh", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLKVSWELHLLLLLGLGLRSQEALPPPCESQIYCHGELLHQIQMAKLYQDDKQFVDMSIATSPDEVLQSFSELAVAYNHSIPRGQLQEFVQRHFQPVGQELEPWVPEDWKDSPQFLQKISDAKLRAWAEQLHQIWKRLGKKMKPEILSYPERFSLIYSEHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMASTVKGMLQNFLDLVETYGHIPNGGRVYYLQRSQPPLLTLMMDLYVTHTKDVSFLQENIGTVASELDFWTVNRTITVNSGGRSYNLNRYYVPYGGPRPESYSKDADLANTVPEGDREALWTELKAGAESGWDFSSRWLVGGPNPDSLSSIRTSKMVPVDLNAFLCQAEGLMSNFYSRLGNDTEATKYRNLRSQRLAAMEALLWDEQKGAWFDYDLEKGKKNLEFYPSNLTPLWTGCFSDPSVIDKALKYLEDNQILTYQYGIPTSLRNTGQQWDLPNAWAPLQDLVIRGLAKSDSPRTREVAFQLAQNWIRTNFKVYSQTSAMYEKYDISNGGHPGGGGEYEVQEGFGWTNGLALVLLDHYGDQLTSGTQLASLGPHCLVAALLISLLLQ", "length": 579 }, "evidence": [ { "id": "E1B8N4", "url": "https://omabrowser.org/oma/group/E1B8N4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3V7Q9-1", "protein_name": "Trehalase", "gene_name": "Treh", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTWELHLLLLLGLGLSSQEALPPPCESQIYCHGELLHQVQMAQLYQDDKQFVDMSLATSPDEVLQKFSELAVAHNHSIPREELQNFVQSYFQPVGQELQPWTPEDWKDSPQFLQKISDSRLRVWAEELHKIWKKLGKKMKAEVLSHPERSSLIYSEHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMASTVKGMLQNFLDLVKTYGHIPNGGRVYYLQRSHPPLLTLMMERYVAHTNDVAFLRENIGTLALELEFWTVNRTVSVGSGGQSYILNRYYVPYGGPRPESYSKDEELAKTVPEGDRETLWAELKAGAESGWDFSSRWLVGGPDPDLLSSIRTSKMVPADLNAFLCQAEELMSNFYSRLGNDTEAKRYRNLRAQRLAAMEAILWDEQKGAWFDYDLEKGKKNLEFYPSNLTPLWAGCFSDPSVADRALKYLEDNKILTYQYGIPTSLRNTGQQWDFPNAWAPLQDLVIRGLAKSASPRTQEVAFQLAQNWIKTNFKVYSQKSAMYEKYDISNGGHPGGGGEYEVQEGFGWTNGLALMLLDRYGDQLTSGTQLASLGPHCLVTALLLSLLLQ", "length": 576 }, "evidence": [ { "id": "E1B8N4", "url": "https://omabrowser.org/oma/group/E1B8N4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LIR5-1", "protein_name": "Trehalase", "gene_name": "TREH", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQRRTWGLHLLLLLGLGLGSWEALPPPCESQIYCHGELLRQVQMARLYQDDKQFVDMPLSVAPDQVLQRFSELAQAHNFSIPQQELQDFIREHFQAVGQELQPWTPEDWKDSPQFLQKILDPKLRAWAGQLHQLWKKLGKKVKPEVLSHPERFSLIYSGHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMPGTVKGMLQNFLDLVQTYGHVPNGARVYYLQRSQPPLLSLMMERYVTQANDTAFLRDNLETLALELDFWTKNRSISVSSGGKSYVLNRYHVPYGGPRPESYSKDAELAATLSEGDHEALWAELKAGAESGWDFSSRWFVGGPNPDSLSSIRTSKLVPVDLNAFLCQAEELMSNFYSRLGNDSQAEKYRNLRAQRMAAMKDILWDEEKGAWFDYDLENGKKNLEFYPSNLAPLWAGCFSDPGDVDKALKYLEDSQILTYHYGIPTSLRKTGQQWDFPNAWAPLQDLVIRGLAKSPSARAQEVAFQLAQNWIRTNFDVYSRRSAMYEKYDISNGGQPGGGGEYEVQEGFGWTNGVVLMLLDRYGDRLSSGTQTVFLEPHCLTAALLLGLMLSLLPQ", "length": 583 }, "evidence": [ { "id": "E1B8N4", "url": "https://omabrowser.org/oma/group/E1B8N4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O43280-1", "protein_name": "Trehalase", "gene_name": "TREH", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPGRTWELCLLLLLGLGLGSQEALPPPCESEIYCHGELLNQVQMAKLYQDDKQFVDMPLSIAPEQVLQTFTELSRDHNHSIPREQLQAFVHEHFQAKGQELQPWTPADWKDSPQFLQKISDAKLRAWAGQLHQLWKKLGKKMKPEVLSHPERFSLIYSEHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMAETVKGMLQNFLDLVKTYGHVPNGGRVYYLQRSQPPLLTLMMDCYLTHTNDTAFLQENIETLALELDFWTKNRTVSVSLEGKNYLLNRYYVPYGGPRPESYSKDVELADTLPEGDREALWAELKAGAESGWDFSSRWLIGGPNPNSLSGIRTSKLVPVDLNAFLCQAEELMSNFYSRLGNDSQATKYRILRSQRLAALNTVLWDEQTGAWFDYDLEKKKKNREFYPSNLTPLWAGCFSDPGVADKALKYLEDNRILTYQYGIPTSLQKTGQQWDFPNAWAPLQDLVIRGLAKAPLRRAQEVAFQLAQNWIRTNFDVYSQKSAMYEKYDVSNGGQPGGGGEYEVQEGFGWTNGVVLMLLDRYGDRLTSGAKLAFLEPHCLAATLLPSLLLSLLPW", "length": 583 }, "evidence": [ { "id": "E1B8N4", "url": "https://omabrowser.org/oma/group/E1B8N4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54QZ5-1", "protein_name": "Trehalase", "gene_name": "treh", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDFLNKKIQKILFICILSFLIVNLTKSEISEVKDVSKFLSVGGGGTGGCQHPIYCNGTLLKTIQLTQVFNDSKTFVDMPMRTSIENVNELFNQLLLNTSKNGGPNKEELAAFLSENFYPAGYEVEPVTPVDWVPNPSFLDEITDPNLVDFARSIHGKWLELTRVFNTSGLCDGCYSSIPVNNPFVIAGSRFREFYYWDSYWIIQGLLVSDMTTTAKGMLRNFGDMITEFGFIPNGGRIYYLNRSQPPLFTQMVNKYFEATNGSDIEFLQEILPILDQEYQWWMTHRTTELTNGETGESVILNLYNVSNNSPRPESYYEDFTDAQSFSSVEEKDYFYSSIASGAESGWDFSSRWMSPSDNTNLTTIQTVDVVPVDLNSILYLNEKILSSFHRTLGNNSMAVYYQAQSESRVDAMQQVFFNEDTYQWNDYNLKTSTNNEAWYTSNILPLFADIQSSIDMDNQEIDLIFKSLANVLIAYPGGVPTSLISAQSLQWDGLNVWPPLQYWIIESIMTPNTTFSNMIGKNLIDRWITTNFCGWNSTLESEGGMMFEKYNANYIGVPGGGGEYVVQNGFGWTNGVDLYLLKKYGKSITLNSC", "length": 594 }, "evidence": [ { "id": "E1B8N4", "url": "https://omabrowser.org/oma/group/E1B8N4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9JLT2-1", "protein_name": "Trehalase", "gene_name": "Treh", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTWELHLLLLLGLGLRSQEALPPPCESQIYCHGELLHQVQMAQLYQDDKQFVDMSLATSPDEVLQKFSELATVHNHSIPKEQLQEFVQSHFQPVGQELQSWTPEDWKDSPQFLQKISDANLRVWAEELHKIWKKLGKKMKAEVLSYPERSSLIYSKHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMASTVKGMLQNFLDLVKTYGHIPNGGRIYYLQRSQPPLLTLMMDRYVAHTKDVAFLQENIGTLASELDFWTVNRTVSVVSGGQSYVLNRYYVPYGGPRPESYRKDAELANSVPEGDRETLWAELKAGAESGWDFSSRWLVGGPDPDLLSSIRTSKMVPADLNAFLCQAEELMSNFYSRLGNDTEATKYRNLRAQRLAAMEAVLWDEQKGAWFDYDLEKGKKNLEFYPSNLSPLWAGCFSDPSVADKALKYLEDSKILTYQYGIPTSLRNTGQQWDFPNAWAPLQDLVIRGLAKSASPRTQEVAFQLAQNWIKTNFKVYSQKSAMFEKYDISNGGHPGGGGEYEVQEGFGWTNGLALMLLDRYGDQLTSGTQLASLGPHCLVAALLLSLLLQ", "length": 576 }, "evidence": [ { "id": "E1B8N4", "url": "https://omabrowser.org/oma/group/E1B8N4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9SU50-1", "protein_name": "Trehalase", "gene_name": "TRE1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MKSYKLNNPNLLISTHTHNKLFLSSSPFNLLFSFPSFIYLKQQRSLFFFFFFFLCFSFTTSMLDSDTDTDSGPVVATTKLVTFLQRVQHTALRSYPKKQTPDPKSYIDLSLKRPYSLSTIESAFDDLTSESHDQPVPVETLEKFVKEYFDGAGEDLLHHEPVDFVSDPSGFLSNVENEEVREWAREVHGLWRNLSCRVSDSVRESADRHTLLPLPEPVIIPGSRFREVYYWDSYWVIKGLMTSQMFTTAKGLVTNLMSLVETYGYALNGARAYYTNRSQPPLLSSMVYEIYNVTKDEELVRKAIPLLLKEYEFWNSGKHKVVIRDANGYDHVLSRYYAMWNKPRPESSVFDEESASGFSTMLEKQRFHRDIATAAESGCDFSTRWMRDPPNFTTMATTSVVPVDLNVFLLKMELDIAFMMKVSGDQNGSDRFVKASKAREKAFQTVFWNEKAGQWLDYWLSSSGEESETWKAENQNTNVFASNFAPIWINSINSDENLVKKVVTALKNSGLIAPAGILTSLTNSGQQWDSPNGWAPQQEMIVTGLGRSSVKEAKEMAEDIARRWIKSNYLVYKKSGTIHEKLKVTELGEYGGGGEYMPQTGFGWSNGVILAFLEEYGWPSHLSIEA", "length": 626 }, "evidence": [ { "id": "E1B8N4", "url": "https://omabrowser.org/oma/group/E1B8N4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9W2M2-1", "protein_name": "Trehalase", "gene_name": "Treh", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFKLPTISLLLVSWSCLVALSQAKTYSLPDLTTDYNNAIPVDEEEAQDPFASCKIYCEGNLLHTIQTAVPKLFADSKTFVDMKLNNSPDKTLEDFNAMMEAKNQTPSSEDLKQFVDKYFSAPGTELEKWTPTDWKENPSFLDLISDPDLKQWGVELNSIWKDLGRKMKDEVSKNPEYYSIIPVPNPVIVPGGRFIEFYYWDSYWIIRGLLYSQMFDTARGMIENFFSIVNRFGFIPNGGRVYYHGRSQPPLLTGMVKSYVDFTNDDKFAIDALDTLEHEFEFFVNNHNVTVKNHSLCVYRDSSSGPRPESYREDVETGEEFPTDEAKELHYSELKAGAESGMDFSSRWFISPTGTNDGNRSALSTTSIVPVDLNAYLYWNAKLIAEFHSKAGNTKKVTEYETKAEKLLLGIQEVLWNEEAGVWLDYDMINQKPRDYYTPTNLSPLWVKAFNISESEKISASVMAYIERNKLDSFPGGVPNTLSYTGEQWDAPNVWAPMQYILVEGLNNLNTPEAKNMSLKWATRWVKTNFAAFSKDRHMYEKYNADEFGVGGGGGEYEVQTGFGWSNGVIIEWLSKHGRDISIGSGCGCLAGEKRQ", "length": 596 }, "evidence": [ { "id": "E1B8N4", "url": "https://omabrowser.org/oma/group/E1B8N4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "alpha,alpha-trehalase activity", "id": "GO:0004555", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004555", "evidence": [ { "database": "UniProtKB", "id": "E1B8N4", "url": "https://www.uniprot.org/uniprotkb/E1B8N4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "trehalose metabolic process", "id": "GO:0005991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005991", "evidence": [ { "database": "UniProtKB", "id": "E1B8N4", "url": "https://www.uniprot.org/uniprotkb/E1B8N4" } ], "pmid": "" }, { "name": "trehalose catabolic process", "id": "GO:0005993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005993", "evidence": [ { "database": "UniProtKB", "id": "E1B8N4", "url": "https://www.uniprot.org/uniprotkb/E1B8N4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 239, "end_pos": 241, "annotation": "n_glycosylation_sequon" }, { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" }, { "start_pos": 369, "end_pos": 371, "annotation": "n_glycosylation_sequon" }, { "start_pos": 78, "end_pos": 80, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "32675", "name": "", "equation": "alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1B8N4-1" ], "evidence": [ { "id": "32675", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/32675" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "E1B8N4", "gene_name": "TREH", "activity": [ { "ec_number": "3.2.1.28", "activity": "alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose.", "evidence": [ { "id": "E1B8N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8N4" } ] }, { "ec_number": "3.2.1.28", "activity": "", "evidence": [ { "id": "E1B8N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8N4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8N4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 579, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8N4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8N4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.2.1.28", "ec_name": "alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose.", "evidence": [ { "id": "3.2.1.28", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.28" }, { "id": "3.2.1.28", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.2.1.28" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 239, "end_pos": 241 }, { "start_pos": 261, "end_pos": 263 }, { "start_pos": 369, "end_pos": 371 }, { "start_pos": 78, "end_pos": 80 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B8K6-1", "uniprot_ac": "E1B8K6", "uniprot_id": "E1B8K6_BOVIN", "mass": { "chemical_mass": 76994.0, "monoisotopic_mass": 76994.0 }, "refseq": {}, "gene_names": [ { "name": "NCL", "type": "recommended", "evidence": [ { "id": "E1B8K6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ] } ], "protein_names": [ { "name": "Nucleolin", "type": "recommended", "evidence": [ { "id": "E1B8K6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8K6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T471", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T471#function" }, { "database": "UniProtKB", "id": "ARBA00024824", "url": "https://www.uniprot.org/uniprotkb/ARBA00024824#function" }, { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NCL", "url": "https://www.uniprot.org/uniprotkb/E1B8K6", "locus": {} } ], "crossref": [ { "id": "E1B8K6", "url": "https://alphafold.ebi.ac.uk/entry/E1B8K6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016174", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016174", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12403", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12403", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12404", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12404", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12405", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12405", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12406", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12406", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "E1B8K6", "url": "https://www.ebi.ac.uk/intact/interactors/id:E1B8K6*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003954", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003954", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034230", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034230", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034233", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034233", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034234", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034234", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034235", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034235", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B8K6", "url": "https://www.orthodb.org/?gene=E1B8K6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23236", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23236", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23236:SF119", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23236:SF119", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T471", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T471", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T471-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T471-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8K6-1", "url": "https://www.uniprot.org/uniprotkb/E1B8K6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVKLAKAGKNQGDSKKMAPPPKEVEEDSEDEEMSEDEDDESSGEEVVIPQKKGKKAATTPAKKMVVSPTKKVAVATPAKKAVVTPGKKAAAMPAKKTVTPAKAVVTPGKKGATPGKAVVATSGKKGAATPGKGAKNGKNAKKEDSDEEDEDDSEEEDDDDEEEDEPAVRKAAAAFGAAPATDDEDDEDDDDDDDEEEEEDEEDEEDEDDSEEEPMEIVPAKGKKAPVKAVPVKAKSTAEDEDEEDDDDDDDEEEEEEDDDDEDDDDEEEEEEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTSFNLFVGNLNFNKSAPELKTGISDLFAKNDLAVVDVRIGVSRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKDRDARTLLAKNLPYKVTQDELKEVFEDAVEIRLVSKDGKSKGIAYIEFKTEADAEKTLEEKQGTEIDGRSISLYYTGEKGQSQDHRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATHIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSIRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDHKPQGKKTKFE", "length": 710, "header": "tr|E1B8K6-1|E1B8K6_BOVIN Isoform 1 of Nucleolin OS=Bos taurus OX=9913 GN=NCL PE=1 SV=2 CANONICAL=E1B8K6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T471-1", "url": "https://www.uniprot.org/uniprotkb/E1B8K6/entry#A0AAA9T471-1", "sequence": { "sequence": "MVKLAKAGKNQGDSKKMAPPPKEVEEDSEDEEMSEDEDDESSGEEVVIPQKKGKKAATTPAKKMVVSPTKKVAVATPAKKAVVTPGKKAAAMPAKKTVTPAKAVVTPGKKGATPGKAVVATSGKKGAATPGKGAKNGKNAKKEDSDEEDEDDSEEEDDDDEEEDEPAVRKAAAAFGAAPATDDEDDEDDDDDDDEEEEEDEEDEEDEDDSEEEPMEIVPAKGKKAPVKAVPVKAKSTAEDEDEEDDDDDDDEEEEEEDDDDEDDDDEEEEEEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTSFNLFVGNLNFNKSAPELKTGISDLFAKNDLAVVDVRIGVSRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKDRDARTLLAKNLPYKVTQDELKEVFEDAVEIRLVSKDGKSKGIAYIEFKTEADAEKTLEEKQGTEIDGRSISLYYTGEKGQSQDHRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATHIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSIRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGDHKPQGKKTKFE", "length": 680, "header": "tr|A0AAA9T471-1|E1B8K6_BOVIN Computationally mapped isoform of Nucleolin OS=Bos taurus OX=9913 GN=NCL PE=1 SV=1 CANONICAL=E1B8K6-1" }, "locus": { "chromosome": "2", "start_pos": 119236767, "end_pos": 119227400, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089561.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089561.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090510.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090510.1" } ] } }, { "isoform_ac": "E1B8K6-1", "url": "https://www.uniprot.org/uniprotkb/E1B8K6/entry#E1B8K6-1", "sequence": { "sequence": "MVKLAKAGKNQGDSKKMAPPPKEVEEDSEDEEMSEDEDDESSGEEVVIPQKKGKKAATTPAKKMVVSPTKKVAVATPAKKAVVTPGKKAAAMPAKKTVTPAKAVVTPGKKGATPGKAVVATSGKKGAATPGKGAKNGKNAKKEDSDEEDEDDSEEEDDDDEEEDEPAVRKAAAAFGAAPATDDEDDEDDDDDDDEEEEEDEEDEEDEDDSEEEPMEIVPAKGKKAPVKAVPVKAKSTAEDEDEEDDDDDDDEEEEEEDDDDEDDDDEEEEEEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTSFNLFVGNLNFNKSAPELKTGISDLFAKNDLAVVDVRIGVSRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKDRDARTLLAKNLPYKVTQDELKEVFEDAVEIRLVSKDGKSKGIAYIEFKTEADAEKTLEEKQGTEIDGRSISLYYTGEKGQSQDHRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATHIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSIRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDHKPQGKKTKFE", "length": 710, "header": "tr|E1B8K6-1|E1B8K6_BOVIN Isoform 1 of Nucleolin OS=Bos taurus OX=9913 GN=NCL PE=1 SV=2 CANONICAL=E1B8K6-1" }, "locus": { "chromosome": "2", "start_pos": 119236767, "end_pos": 119227400, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021529.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021529.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021529.5", "url": "https://www.ensembl.org/id/ENSBTAP00000021529.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 129, "start_aa": "Thr", "end_pos": 129, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr129", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "regulation of RNA metabolic process", "id": "GO:0051252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051252", "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "pmid": "" }, { "name": "positive regulation of macromolecule biosynthetic process", "id": "GO:0010557", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010557", "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "pmid": "" }, { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "pmid": "" }, { "name": "negative regulation of translation", "id": "GO:0017148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017148", "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "pmid": "" }, { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "pmid": "" }, { "name": "positive regulation of transcription of nucleolar large rRNA by RNA polymerase I", "id": "GO:1901838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901838", "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "pmid": "" }, { "name": "telomeric DNA binding", "id": "GO:0042162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042162", "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "pmid": "" }, { "name": "DNA topoisomerase binding", "id": "GO:0044547", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044547", "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "pmid": "" }, { "name": "insulin receptor substrate binding", "id": "GO:0043560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043560", "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "pmid": "" }, { "name": "mRNA 5'-UTR binding", "id": "GO:0048027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048027", "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "pmid": "" }, { "name": "PH domain binding", "id": "GO:0042731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042731", "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "E1B8K6", "url": "https://www.uniprot.org/uniprotkb/E1B8K6" } ], "pmid": "" }, { "name": "spliceosomal complex", "id": "GO:0005681", "url": 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"https://www.orthodb.org/?gene=A0A3Q1LJC2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M4F6", "url": "https://www.orthodb.org/?gene=A0A3Q1M4F6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M6S9", "url": "https://www.orthodb.org/?gene=A0A3Q1M6S9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MC78", "url": "https://www.orthodb.org/?gene=A0A3Q1MC78", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N318", "url": "https://www.orthodb.org/?gene=A0A3Q1N318", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A7MB28", "url": "https://www.orthodb.org/?gene=A7MB28", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11034", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11034", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095466", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJC2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJC2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJC2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4F6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4F6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M6S9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6S9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M6S9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6S9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC78", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC78-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC78-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N318", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N318", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N318-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N318-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD87-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXN6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z747", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z747", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z747-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z747-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7MB28", "url": "https://www.uniprot.org/uniprotkb/A7MB28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7MB28-1", "url": "https://www.uniprot.org/uniprotkb/A7MB28-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDELQDVQLTEIKPLLNDKNGTRNFQDFDCQEHDIETAHGMVHVTIRGLPKGNRPVILTYHDIGLNHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQEGAPSFPTGYQYPTMDELAEMLPPVLTHLNLKSIIGIGVGAGAYILSRFALNHPELVEGLVLINVDPCAKGWIDWAASKLSGLTTNVVDIILSHHFGQEELQANLDLIQTYRLHIAQDINQENLQLFLGSYNGRKDLEIERPILGQNDNKSKTLKCSTLLVVGDSSPAVEAVVECNSRLNPVNTTLLKMADCGGLPQVVQPGKLTEAFKYFLQGMGYIPSASMTRLARSRTHSTSSSIGSGESAFSRSVASNQSDGTQESSESPDVLDRHQTMEVSC", "length": 375, "header": "sp|A7MB28-1|NDRG3_BOVIN Isoform 1 of Protein NDRG3 OS=Bos taurus OX=9913 GN=NDRG3 PE=2 SV=1 CANONICAL=A7MB28-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJC2-1", "url": "https://www.uniprot.org/uniprotkb/A7MB28/entry#A0A3Q1LJC2-1", "sequence": { "sequence": "MQILRVTDLFLRILYSSGLMDELQDVQLTEIKPLLNDKNGTRNFQDFDCQEHDIETAHGMVHVTIRGLPKGNRPVILTYHDIGLNHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQEGAPSFPTGYQYPTMDELAEMLPPVLTHLNLKSIIGIGVGAGAYILSRFALNHPELVEGLVLINVDPCAKGWIDWAASKLSGLTTNVVDIILSHHFGQEELQANLDLIQTYRLHIAQDINQENLQLFLGSYNGRKDLEIERPILGQNDNKSKTLKCSTLLVVGDSSPAVEAVVECNSRLNPVNTTLLKMADCGGLPQVVQPGKLTEAFKYFLQGMGYIPSASMTRLARSRTHSTSSSIGSGESAFSRSVASNQSDGTQESSESPDVLDRHQTMEVSC", "length": 394, "header": "tr|A0A3Q1LJC2-1|NDRG3_BOVIN Computationally mapped isoform of Protein NDRG3 OS=Bos taurus OX=9913 GN=NDRG3 PE=2 SV=2 CANONICAL=A7MB28-1" }, "locus": { "chromosome": "13", "start_pos": 65789450, "end_pos": 65741762, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081156.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081156.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059461.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059461.2" } ] } }, { "isoform_ac": "A0A3Q1M4F6-1", "url": "https://www.uniprot.org/uniprotkb/A7MB28/entry#A0A3Q1M4F6-1", "sequence": { "sequence": "MGLLSTPLASETSIFSEGAALDKNGTRNFQDFDCQEHDIETAHGMVHVTIRGLPKGNRPVILTYHDIGLNHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQEGAPSFPTGYQYPTMDELAEMLPPVLTHLNLKSIIGIGVGAGAYILSRFALNHPELVEGLVLINVDPCAKGWIDWAASKLSGLTTNVVDIILSHHFGQEELQANLDLIQTYRLHIAQDINQENLQLFLGSYNGRKDLEIERPILGQNDNKSKTLKCSTLLVVGDSSPAVEAVVECNSRLNPVNTTLLKMADCGGLPQVVQPGKLTEAFKYFLQGMGYIPSASMTRLARSRTHSTSSSIGSGESAFSRSVASNQSDGTQESSESPDVLDRHQTMEVSC", "length": 379, "header": "tr|A0A3Q1M4F6-1|NDRG3_BOVIN Computationally mapped isoform of Protein NDRG3 OS=Bos taurus OX=9913 GN=NDRG3 PE=2 SV=2 CANONICAL=A7MB28-1" }, "locus": { "chromosome": "13", "start_pos": 65781705, "end_pos": 65741762, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073178.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073178.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063130.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063130.2" } ] } }, { "isoform_ac": "A0A3Q1M6S9-1", "url": "https://www.uniprot.org/uniprotkb/A7MB28/entry#A0A3Q1M6S9-1", "sequence": { "sequence": "MDELQDVQLTEIKPLLNDKNGTRNFQDFDCQEHDIETAHGMVHVTIRGLPKGNRPVILTYHDIGLNHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQEGAPSFPTGYQYPTMDELAEMLPPVLTHLNLKSIIGIGVGAGAYILSRFALNHPELVEGLVLINVDPCAKGWIDWAASKEELQANLDLIQTYRLHIAQDINQENLQLFLGSYNGRKDLEIERPILGQNDNKSKTLKCSTLLVVGDSSPAVEAVVECNSRLNPVNTTLLKMADCGGLPQVVQPGKLTEAFKYFLQGMGYIPSASMTRLARSRTHSTSSSIGSGESAFSRSVASNQSDGTQESSESPDVLDRHQTMEVSC", "length": 356, "header": "tr|A0A3Q1M6S9-1|NDRG3_BOVIN Computationally mapped isoform of Protein NDRG3 OS=Bos taurus OX=9913 GN=NDRG3 PE=2 SV=1 CANONICAL=A7MB28-1" }, "locus": { "chromosome": "13", "start_pos": 65789108, "end_pos": 65741762, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084910.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084910.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064055.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064055.1" } ] } }, { "isoform_ac": "A0A3Q1MC78-1", "url": "https://www.uniprot.org/uniprotkb/A7MB28/entry#A0A3Q1MC78-1", "sequence": { "sequence": "MDELQDVQLTEIKPLLNDKEHDIETAHGMVHVTIRGLPKGNRPVILTYHDIGLNHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQEGAPSFPTGYQYPTMDELAEMLPPVLTHLNLKSIIGIGVGAGAYILSRFALNHPELVEGLVLINVDPCAKGWIDWAASKLSGLTTNVVDIILSHHFGQEELQANLDLIQTYRLHIAQDINQENLQLFLGSYNGRKDLEIERPILGQNDNKSKTLKCSTLLVVGDSSPAVEAVVECNSRLNPVNTTLLKMADCGGLPQVVQPGKLTEAFKYFLQGMGYIPYVQLSHLSTESVPSASMTRLARSRTHSTSSSIGSGESAFSRSVASNQSDGTQESSESPDVLDRHQTMEVSC", "length": 376, "header": "tr|A0A3Q1MC78-1|NDRG3_BOVIN Computationally mapped isoform of Protein NDRG3 OS=Bos taurus OX=9913 GN=NDRG3 PE=2 SV=2 CANONICAL=A7MB28-1" }, "locus": { "chromosome": "13", "start_pos": 65789108, "end_pos": 65741762, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085554.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085554.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067925.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067925.2" } ] } }, { "isoform_ac": "A0A3Q1N318-1", "url": "https://www.uniprot.org/uniprotkb/A7MB28/entry#A0A3Q1N318-1", "sequence": { "sequence": "MDELQDVQLTEIKPLLNDKNGTRNFQDFDCQLQAETCSSHSHRRSQRIYLRVHMEEHDIETAHGMVHVTIRGLPKGNRPVILTYHDIGLNHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQEGAPSFPTGYQYPTMDELAEMLPPVLTHLNLKSIIGIGVGAGAYILSRFALNHPELVEGLVLINVDPCAKGWIDWAASKLSGLTTNVVDIILSHHFGQEELQANLDLIQTYRLHIAQDINQENLQLFLGSYNGRKDLEIERPILGQNDNKSKTLKCSTLLVVGDSSPAVEAVVECNSRLNPVNTTLLKMADCGGLPQVVQPGKLTEAFKYFLQGMGYIPSASMTRLARSRTHSTSSSIGSGESAFSRSVASNQSDGTQESSESPDVLDRHQTMEVSC", "length": 399, "header": "tr|A0A3Q1N318-1|NDRG3_BOVIN Computationally mapped isoform of Protein NDRG3 OS=Bos taurus OX=9913 GN=NDRG3 PE=2 SV=2 CANONICAL=A7MB28-1" }, "locus": { "chromosome": "13", "start_pos": 65789108, "end_pos": 65741762, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084147.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084147.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063734.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063734.2" } ] } }, { "isoform_ac": "A0AAA9TD87-1", "url": "https://www.uniprot.org/uniprotkb/A7MB28/entry#A0AAA9TD87-1", "sequence": { "sequence": "MREKSLYAEDGANSTIVSIVPQPGRHSAHALPGVLSAPARPHSLPRPTPAAAAAAAAAAAALTAVAGASGECERLSLVDWGRAVLPVGSSFPLPSSPPHHPSAPGLGVTDLFLRILYSSGLMDELQDVQLTEIKPLLNDKNGTRNFQDFDCQEHDIETAHGMVHVTIRGLPKGNRPVILTYHDIGLNHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQEGAPSFPTGYQYPTMDELAEMLPPVLTHLNLKSIIGIGVGAGAYILSRFALNHPELVEGLVLINVDPCAKGWIDWAASKLSGLTTNVVDIILSHHFGQEELQANLDLIQTYRLHIAQDINQENLQLFLGSYNGRKDLEIERPILGQNDNKSKTLKCSTLLVVGDSSPAVEAVVECNSRLNPVNTTLLKMADCGGLPQVVQPGKLTEAFKYFLQGMGYIPSASMTRLARSRTHSTSSSIGSGESAFSRSVASNQSDGTQESSESPDVLDRHQTMEVSC", "length": 496, "header": "tr|A0AAA9TD87-1|NDRG3_BOVIN Computationally mapped isoform of Protein NDRG3 OS=Bos taurus OX=9913 GN=NDRG3 PE=2 SV=1 CANONICAL=A7MB28-1" }, "locus": { "chromosome": "13", "start_pos": 65803653, "end_pos": 65741762, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098089.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098089.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094815.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094815.1" } ] } }, { "isoform_ac": "A0AAA9TXN6-1", "url": "https://www.uniprot.org/uniprotkb/A7MB28/entry#A0AAA9TXN6-1", "sequence": { "sequence": "MVHETSRTLTVRYQYPTMDELAEMLPPVLTHLNLKSIIGIGVGAGAYILSRFALNHPELVEGLVLINVDPCAKGWIDWAASKLSGLTTNVVDIILSHHFGQEELQANLDLIQTYRLHIAQDINQENLQLFLGSYNGRKDLEIERPILGQNDNKSKTLKCSTLLVVGDSSPAVEAVVECNSRLNPVNTTLLKMADCGGLPQVVQPGKLTEAFKYFLQGMGYIPSASMTRLARSRTHSTSSSIGSGESAFSRSVASNQSDGTQESSESPDVLDRHQTMEVSC", "length": 280, "header": "tr|A0AAA9TXN6-1|NDRG3_BOVIN Computationally mapped isoform of Protein NDRG3 OS=Bos taurus OX=9913 GN=NDRG3 PE=2 SV=1 CANONICAL=A7MB28-1" }, "locus": { "chromosome": "13", "start_pos": 65780723, "end_pos": 65741762, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098195.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098195.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103099.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103099.1" } ] } }, { "isoform_ac": "A0AAF6Z747-1", "url": "https://www.uniprot.org/uniprotkb/A7MB28/entry#A0AAF6Z747-1", "sequence": { "sequence": "MDELQDVQLTEIKPLLNDKNGTRNFQDFDCQEHDIETAHGMVHVTIRGLPKGNRPVILTYHDIGLNHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQEGAPSFPTGYQYPTMDELAEMLPPVLTHLNLKSIIGIGVGAGAYILSRFALNHPELVEGLVLINVDPCAKGWIDWAASKLSGLTTNVVDIILSHHFGQEELQANLDLIQTYRLHIAQDINQENLQLFLGSYNGRKDLEIERPILGQNDNKSKTLKCSTLLVVGDSSPAVEAVMADCGGLPQVVQPGKLTEAFKYFLQGMGYIPSASMTRLARSRTHSTSSSIGSGESAFSRSVASNQSDGTQESSESPDVLDRHQTMEVSC", "length": 359, "header": "tr|A0AAF6Z747-1|NDRG3_BOVIN Computationally mapped isoform of Protein NDRG3 OS=Bos taurus OX=9913 GN=NDRG3 PE=2 SV=1 CANONICAL=A7MB28-1" }, "locus": { "chromosome": "13", "start_pos": 65789108, "end_pos": 65741762, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026141.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026141.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026141.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026141.6" } ] } }, { "isoform_ac": "A7MB28-1", "url": "https://www.uniprot.org/uniprotkb/A7MB28/entry#A7MB28-1", "sequence": { "sequence": "MDELQDVQLTEIKPLLNDKNGTRNFQDFDCQEHDIETAHGMVHVTIRGLPKGNRPVILTYHDIGLNHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQEGAPSFPTGYQYPTMDELAEMLPPVLTHLNLKSIIGIGVGAGAYILSRFALNHPELVEGLVLINVDPCAKGWIDWAASKLSGLTTNVVDIILSHHFGQEELQANLDLIQTYRLHIAQDINQENLQLFLGSYNGRKDLEIERPILGQNDNKSKTLKCSTLLVVGDSSPAVEAVVECNSRLNPVNTTLLKMADCGGLPQVVQPGKLTEAFKYFLQGMGYIPSASMTRLARSRTHSTSSSIGSGESAFSRSVASNQSDGTQESSESPDVLDRHQTMEVSC", "length": 375, "header": "sp|A7MB28-1|NDRG3_BOVIN Isoform 1 of Protein NDRG3 OS=Bos taurus OX=9913 GN=NDRG3 PE=2 SV=1 CANONICAL=A7MB28-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 322, "end_pos": 322, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A7MB28", "url": "https://www.uniprot.org/uniprotkb/A7MB28" } ], "site_lbl": "Thr322" }, { "start_pos": 329, "end_pos": 329, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A7MB28", "url": "https://www.uniprot.org/uniprotkb/A7MB28" } ], "site_lbl": "Thr329" }, { "start_pos": 331, "end_pos": 331, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7MB28", "url": "https://www.uniprot.org/uniprotkb/A7MB28" } ], "site_lbl": "Ser331" }, { "start_pos": 332, "end_pos": 332, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A7MB28", "url": "https://www.uniprot.org/uniprotkb/A7MB28" } ], "site_lbl": "Thr332" }, { "start_pos": 334, "end_pos": 334, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7MB28", "url": "https://www.uniprot.org/uniprotkb/A7MB28" } ], "site_lbl": "Ser334" }, { "start_pos": 335, "end_pos": 335, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7MB28", "url": "https://www.uniprot.org/uniprotkb/A7MB28" } ], "site_lbl": "Ser335" }, { "start_pos": 338, "end_pos": 338, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7MB28", "url": "https://www.uniprot.org/uniprotkb/A7MB28" } ], "site_lbl": "Ser338" }, { "start_pos": 341, "end_pos": 341, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7MB28", "url": "https://www.uniprot.org/uniprotkb/A7MB28" } ], "site_lbl": "Ser341" }, { "start_pos": 352, "end_pos": 352, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7MB28", "url": "https://www.uniprot.org/uniprotkb/A7MB28" } ], "site_lbl": "Ser352" }, { "start_pos": 355, "end_pos": 355, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A7MB28", "url": "https://www.uniprot.org/uniprotkb/A7MB28" } ], "site_lbl": "Thr355" }, { "start_pos": 361, "end_pos": 361, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7MB28", "url": "https://www.uniprot.org/uniprotkb/A7MB28" } ], "site_lbl": "Ser361" }, { "start_pos": 374, "end_pos": 374, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7MB28", "url": "https://www.uniprot.org/uniprotkb/A7MB28" } ], "site_lbl": "Ser374" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514399", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514399", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A7MB28", "url": "https://www.uniprot.org/uniprotkb/A7MB28" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A7MB28", "url": "https://www.uniprot.org/uniprotkb/A7MB28" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A7MB28", "url": "https://www.uniprot.org/uniprotkb/A7MB28" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A7MB28", "url": "https://www.uniprot.org/uniprotkb/A7MB28" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "A7MB28", "url": "https://www.uniprot.org/uniprotkb/A7MB28" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 20, "end_pos": 22, "annotation": "n_glycosylation_sequon" }, { "start_pos": 247, "end_pos": 249, "annotation": "n_glycosylation_sequon" }, { "start_pos": 281, "end_pos": 283, "annotation": "n_glycosylation_sequon" }, { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7MB28-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 375, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7MB28-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7MB28" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], 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"count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BD52-1", "uniprot_ac": "E1BD52", "uniprot_id": "TM245_BOVIN", "mass": { "chemical_mass": 96123.0, "monoisotopic_mass": 96123.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM245", "type": "recommended", "evidence": [ { "id": "E1BD52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD52" } ] } ], "protein_names": [ { "name": "Transmembrane protein 245", "type": "recommended", "evidence": [ { "id": "E1BD52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD52/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BD52", "url": "https://www.uniprot.org/uniprotkb/E1BD52" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM245", "url": "https://www.uniprot.org/uniprotkb/E1BD52", "locus": { "chromosome": "8", "start_pos": 98607111, "end_pos": 98686370, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038794", "url": "https://www.ensembl.org/id/ENSBTAG00000038794" } ] } } ], "crossref": [ { "id": "E1BD52", "url": "https://alphafold.ebi.ac.uk/entry/E1BD52", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038794", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038794", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "521172", "url": "https://www.ncbi.nlm.nih.gov/gene/521172", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002549", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002549", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521172", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521172", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR21716", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21716", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21716:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21716:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01594", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01594", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LJP7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJP7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJP7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJF0", "url": "https://www.uniprot.org/uniprotkb/A0A452DJF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJF0-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJF0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD52", "url": "https://www.uniprot.org/uniprotkb/E1BD52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD52-1", "url": "https://www.uniprot.org/uniprotkb/E1BD52-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADDGGPEEALSPRGSPSRVPRVQRPVGAASGGGGCGETPRTAALALRFDKPIKQAFYNTGAVLFVCLCCGAAVLVYFILEAFLRPLLWAVLCGTFLHPFKSSLTRLGRHWLQRLHRAHTPIVLAALLLPICFADYGVEALGEQALRRRRLLLLLGAGGPLLYGLYSLGSYLGVQVLLAHAGALICCGLDYFNSLWIWTLVVGYVLAVSFKWNASTERYLRAMSIPVWIILLFHLASLAGAWRIPVFLVIVFLMSVGTLYEKQNGKESSGAELPGQVISMAASTLATLAISITGYESSTEDHTSTQPAETETMDRGEPPPTLSSSSSPTSPSPPPGRQRSEAGTFLRKKKTSDVYFVSLLWAIVGVQIWSNLWIVQLLPVPIAVWVLKKLVIHFGVVNFLEKRCSVWWQATEHFLRERQQALAPWPIIGLGKFLLKVDSKLWHWLNKKMIIWLEKMLDKIISIFIIFLLVIGTLLLALLLTAKVHQESVHMIEVTSNLINETLANHPEWANWLPEAQVVQRALNSAANNVYQYGREWITHKLHKILGDKVNNTAVIEKQVLELWDRLYHSWFVKNVSHSGRHRGHKLHISRQNSWLGDILDWQDIASFVHENIETFLSILESLWVVMSRNVSLLFSTITTLLTILFYSGTALLNFVLSLIIFLTTLFYLLSSSDEYYKPVKWVISLTPLSQPGPSSNIIGQSVEEAIRHSRGVFDASLKMAGFYGLYTWLTHTIFGINIVFIPSALAAILGAVPFLGTYWAAVPAVLDLWLTQGLGCKAILLLVFHLLPTYFVDTAIYSDISGGGHPYLTGLAVAGGAYYLGLEGAIIGPILLCILVVASNIYSAMLVSPTNSVPTPNQTPWPAQAQR", "length": 868, "header": "sp|E1BD52-1|TM245_BOVIN Isoform 1 of Transmembrane protein 245 OS=Bos taurus OX=9913 GN=TMEM245 PE=3 SV=1 CANONICAL=E1BD52-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJP7-1", "url": "https://www.uniprot.org/uniprotkb/E1BD52/entry#A0A3Q1LJP7-1", "sequence": { "sequence": "MADDGGPEEALSPRGSPSRVPRVQRPVGAASGGGGCGETPRTAALALRFDKPIKQAFYNTGAVLFVCLCCGAAVLVYFILEAFLRPLLWAVLCGTFLHPFKSSLTRLGRHWLQRLHRAHTPIVLAALLLPICFADYGVEALGEQALRRRRLLLLLGAGGPLLYGLYSLGSYLGVQVLLAHAGALICCGLDYFNSLWIWTLVVGYVLAVSFKWNASTERYLRAMSIPVWIILLFHLASLAGAWRIPVFLVIVFLMSVGTLYEKQNGKESSGAELPGQVISMAASTLATLAISITGYESSTEDHTSTQPAETETMDRGEPPPTLSSSSSPTSPSPPPGRQRSEAGTFLRKKKTSDVYFVSLLWAIVGVQIWSNLWIVQLLPVPIAVWVLKKLVIHFGVVNFLEKRCSVWWQATEHFLRERQQALAPWPIIGLGKFLLKVDSKLWHWLNKKMIIWLEKMLDKIISIFIIFLLVIGTLLLALLLTAKVHQESVHMIEVTSNLINETLANHPEWANWLPEAQVVQRALNSAANNVYQYGREWITHKLHKILGDKVNNTAVIEKQVLELWDRLYHSWFVKNVSHSGRHRGHKLHISRQNSWLGDILDWQDIASFVHENIETFLSILESLWVVMSRNVSLLFSTITTLLTILFYSGTALLNFVLSLIIFLTTLFYLLSSSDEYYKPVKWVISLTPLSQPGPSSNIIGQSVEEAIRGVFDASLKMAGFYGLYTWLTHTIFGINIVFIPSALAAILGAVPFLGTYWAAVPAVLDLWLTQGLGCKAILLLVFHLLPTYFVDTAIYSDISGGGHPYLTGLAVAGGAYYLGLEGAIIGPILLCILVVASNIYSAMLVSPTNSVPTPNQTPWPAQAQRTFRDISEDLKPSVD", "length": 879, "header": "tr|A0A3Q1LJP7-1|TM245_BOVIN Computationally mapped isoform of Transmembrane protein 245 OS=Bos taurus OX=9913 GN=TMEM245 PE=3 SV=2 CANONICAL=E1BD52-1" }, "locus": { "chromosome": "8", "start_pos": 98686172, "end_pos": 98608115, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082231.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082231.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059685.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059685.2" } ] } }, { "isoform_ac": "A0A452DJF0-1", "url": "https://www.uniprot.org/uniprotkb/E1BD52/entry#A0A452DJF0-1", "sequence": { "sequence": "MADDGGPEEALSPRGSPSRVPRVQRPVGAASGGGGCGETPRTAALALRFDKPIKQAFYNTGAVLFVCLCCGAAVLVYFILEAFLRPLLWAVLCGTFLHPFKSSLTRLGRHWLQRLHRAHTPIVLAALLLPICFADYGVEALGEQALRRRRLLLLLGAGGPLLYGLYSLGSYLGVQVLLAHAGALICCGLDYFNSLWIWTLVVGYVLAVSFKWNASTERYLRAMSIPVWIILLFHLASLAGAWRIPVFLVIVFLMSVGTLYEKQNGKESSGAELPGQVISMAASTLATLAISITGYESSTEDHTSTQPAETETMDRGEPPPTLSSSSSPTSPSPPPGRQRSEAGTFLRKKKTSDVYFVSLLWAIVGVQIWSNLWIVQLLPVPIAVWVLKKLVIHFGVVNFLEKRCSVWWQATEHFLRERQQALAPWPIIGLGKFLLKVDSKMIIWLEKMLDKIISIFIIFLLVIGTLLLALLLTAKVHQESVHMIEVTSNLINETLANHPEWANWLPEAQVVQRALNSAANNVYQYGREWITHKLHKILGDKVNNTAVIEKQVLELWDRLYHSWFVKNVSHSGRHRGHKLHISRQNSWLGDILDWQDIASFVHENIETFLSILESLWVVMSRNVSLLFSTITTLLTILFYSGTALLNFVLSLIIFLTTLFYLLSSSDEYYKPVKWVISLTPLSQPGPSSNIIGQSVEEAIRGVFDASLKMAGFYGLYTWLTHTIFGINIVFIPSALAAILGAVPFLGTYWAAVPAVLDLWLTQGLGCKAILLLVFHLLPTYFVDTAIYSDISGGGHPYLTGLAVAGGAYYLGLEGAIIGPILLCILVVASNIYSAMLVSPTNSVPTPNQTPWPAQAQRTFRDISEDLKPSVD", "length": 871, "header": "tr|A0A452DJF0-1|TM245_BOVIN Computationally mapped isoform of Transmembrane protein 245 OS=Bos taurus OX=9913 GN=TMEM245 PE=3 SV=2 CANONICAL=E1BD52-1" }, "locus": { "chromosome": "8", "start_pos": 98686172, "end_pos": 98608115, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053653.3", "url": "https://www.ensembl.org/id/ENSBTAT00000053653.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047510.3", "url": "https://www.ensembl.org/id/ENSBTAP00000047510.3" } ] } }, { "isoform_ac": "E1BD52-1", "url": "https://www.uniprot.org/uniprotkb/E1BD52/entry#E1BD52-1", "sequence": { "sequence": "MADDGGPEEALSPRGSPSRVPRVQRPVGAASGGGGCGETPRTAALALRFDKPIKQAFYNTGAVLFVCLCCGAAVLVYFILEAFLRPLLWAVLCGTFLHPFKSSLTRLGRHWLQRLHRAHTPIVLAALLLPICFADYGVEALGEQALRRRRLLLLLGAGGPLLYGLYSLGSYLGVQVLLAHAGALICCGLDYFNSLWIWTLVVGYVLAVSFKWNASTERYLRAMSIPVWIILLFHLASLAGAWRIPVFLVIVFLMSVGTLYEKQNGKESSGAELPGQVISMAASTLATLAISITGYESSTEDHTSTQPAETETMDRGEPPPTLSSSSSPTSPSPPPGRQRSEAGTFLRKKKTSDVYFVSLLWAIVGVQIWSNLWIVQLLPVPIAVWVLKKLVIHFGVVNFLEKRCSVWWQATEHFLRERQQALAPWPIIGLGKFLLKVDSKLWHWLNKKMIIWLEKMLDKIISIFIIFLLVIGTLLLALLLTAKVHQESVHMIEVTSNLINETLANHPEWANWLPEAQVVQRALNSAANNVYQYGREWITHKLHKILGDKVNNTAVIEKQVLELWDRLYHSWFVKNVSHSGRHRGHKLHISRQNSWLGDILDWQDIASFVHENIETFLSILESLWVVMSRNVSLLFSTITTLLTILFYSGTALLNFVLSLIIFLTTLFYLLSSSDEYYKPVKWVISLTPLSQPGPSSNIIGQSVEEAIRHSRGVFDASLKMAGFYGLYTWLTHTIFGINIVFIPSALAAILGAVPFLGTYWAAVPAVLDLWLTQGLGCKAILLLVFHLLPTYFVDTAIYSDISGGGHPYLTGLAVAGGAYYLGLEGAIIGPILLCILVVASNIYSAMLVSPTNSVPTPNQTPWPAQAQR", "length": 868, "header": "sp|E1BD52-1|TM245_BOVIN Isoform 1 of Transmembrane protein 245 OS=Bos taurus OX=9913 GN=TMEM245 PE=3 SV=1 CANONICAL=E1BD52-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 213, "start_aa": "Asn", "end_pos": 213, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn213", "evidence": [ { "id": "E1BD52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD52#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 500, "start_aa": "Asn", "end_pos": 500, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn500", "evidence": [ { "id": "E1BD52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD52#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 551, "start_aa": "Asn", "end_pos": 551, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn551", "evidence": [ { "id": "E1BD52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD52#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 575, "start_aa": "Asn", "end_pos": 575, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn575", "evidence": [ { "id": "E1BD52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD52#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 12, "end_pos": 12, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "E1BD52", "url": "https://www.uniprot.org/uniprotkb/E1BD52" } ], "site_lbl": "Ser12" }, { "start_pos": 16, "end_pos": 16, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "E1BD52", "url": "https://www.uniprot.org/uniprotkb/E1BD52" } ], "site_lbl": "Ser16" }, { "start_pos": 327, "end_pos": 327, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "E1BD52", "url": "https://www.uniprot.org/uniprotkb/E1BD52" } ], "site_lbl": "Ser327" }, { "start_pos": 330, "end_pos": 330, "kinase_uniprot_canonical_ac": 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"database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRAEAAAMIPGLALLWAAGLGGAAPSTPRLRLSFQELQARHGLRTFRLERTCCYEALLLDEERGRLFVGAENHVASLSLDNISKRAKKLAWPARVEWREECNWAGKDIGTECMNFVKLLHAYNHTHLLACGTGAFHPICAFVEVGQRLEEPMLRLDPRRLEDGKGKSPYDPRHRAASVLVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFIKVFWIPESENPDDDKIYFFFRESAVEATPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGAEGDTNFDQLRPFPTEDVFLLSSRDRWTPLLYAVFSTSSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPIGGRPLFQQVGAGYTFTQITADRVAAADGYYDVLFIGTDVGTVLKVISVPKGGWPNAEGLLLEELHMFEDSAAVTSMQISSKRHQLYVASRSGVAQIPLHRCAAHGRACAECCLARDPYCAWDGAKCTRFQPSAKRRFRRQDVRNGDPSTLCSGDSSHPVLLEQKVLGVEGGSAFLECEARSLQAHVEWTFQRAGESAYTQVPAEERAERTRRGLLLRGLRRGDSGLYLCAAVEQGFSQPLRRLALHVLSAAQAERLARTEDTAPVAPPGPKLWYRDFLQLVEPGGGGANSLRMCRPQPAPRPQVPESRRKGRNRRTHAPELRAERGPRSAADW", "length": 753, "header": "tr|E1B9T2-1|E1B9T2_BOVIN Isoform 1 of Semaphorin-3B OS=Bos taurus OX=9913 GN=SEMA3B PE=3 SV=4 CANONICAL=E1B9T2-1" }, "isoforms": [ { 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"MGRAEAAAMIPGLALLWAAGLGGAAPSTPRLRLSFQELQARHGLRTFRLERTCCYEALLLDEERGRLFVGAENHVASLSLDNISKRAKKLAWPARVEWREECNWAGKDIGTECMNFVKLLHAYNHTHLLACGTGAFHPICAFVEVGQRLEEPMLRLDPRRLEDGKGKSPYDPRHRAASVLVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFIKVFWIPESENPDDDKIYFFFRESAVEATPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGAEGDTNFDQLRPFPTEDVFLLSSRDRWTPLLYAVFSTSSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPIGGRPLFQQVGAGYTFTQITADRVAAADGYYDVLFIGTDVGTVLKVISVPKGGWPNAEGLLLEELHMFEDSAAVTSMQISSKRHQLYVASRSGVAQIPLHRCAAHGRACAECCLARDPYCAWDGAKCTRFQPSAKRRFRRQDVRNGDPSTLCSGDSSHPVLLEQKVLGVEGGSAFLECEARSLQAHVEWTFQRAGESAYTQVPAEERAERTRRGLLLRGLRRGDSGLYLCAAVEQGFSQPLRRLALHVLSAAQAERLARTEDTAPVAPPGPKLWYRDFLQLVEPGGGGANSLRMCRPQPAPRPQVPESRRKGRNRRTHAPELRAERGPRSAADW", "length": 753, "header": "tr|E1B9T2-1|E1B9T2_BOVIN Isoform 1 of Semaphorin-3B OS=Bos taurus OX=9913 GN=SEMA3B PE=3 SV=4 CANONICAL=E1B9T2-1" }, "locus": { "chromosome": "22", "start_pos": 50091122, "end_pos": 50084784, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013382.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013382.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013382.7", "url": "https://www.ensembl.org/id/ENSBTAP00000013382.7" } ] } }, { "isoform_ac": "E1BID4-1", "url": "https://www.uniprot.org/uniprotkb/E1B9T2/entry#E1BID4-1", "sequence": { "sequence": "QVPAEERAERTRRGLLLRGLRRGDSGLYLCAAVEQGFSQPLRRLALHVLSAAQAERLARTEDTAPVAPPGPKLCPRRAHRSLSHGERAATGGHTPQSCGLSGAHAAQRTDTAALTRSRAPLAPSHGQEVRLHRVESISDLHNGGPLCPYLAEEGQPWGELLGVLPPALCAQTGCGPVHSRGAFLLLLALLVLICLALAVLAVYLSVLQSESLRVLAHTLRTQEEVLLKLRLASLSQLRRLNSSEAQAPS", "length": 249, "header": "tr|E1BID4-1|E1B9T2_BOVIN Computationally mapped isoform of Semaphorin-3B OS=Bos taurus OX=9913 GN=SEMA3B PE=3 SV=4 CANONICAL=E1B9T2-1" }, "locus": { "chromosome": "22", "start_pos": 50085185, "end_pos": 50067286, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000605.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000605.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000605.7", "url": "https://www.ensembl.org/id/ENSBTAP00000000605.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 254, "start_aa": "Thr", "end_pos": 254, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr254", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616532", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616532", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B9T2", "url": "https://www.uniprot.org/uniprotkb/E1B9T2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1B9T2", "url": "https://www.uniprot.org/uniprotkb/E1B9T2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "semaphorin receptor binding", "id": "GO:0030215", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030215", "evidence": [ { "database": "UniProtKB", "id": "E1B9T2", "url": "https://www.uniprot.org/uniprotkb/E1B9T2" } ], "pmid": "" }, { "name": "neuropilin binding", "id": "GO:0038191", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038191", "evidence": [ { "database": "UniProtKB", "id": "E1B9T2", "url": "https://www.uniprot.org/uniprotkb/E1B9T2" } ], "pmid": "" }, { "name": "chemorepellent activity", "id": "GO:0045499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045499", "evidence": [ { "database": "UniProtKB", "id": "E1B9T2", "url": "https://www.uniprot.org/uniprotkb/E1B9T2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "E1B9T2", "url": "https://www.uniprot.org/uniprotkb/E1B9T2" } ], "pmid": "" }, { "name": "semaphorin-plexin signaling pathway", "id": "GO:0071526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071526", "evidence": [ { "database": "UniProtKB", "id": "E1B9T2", "url": "https://www.uniprot.org/uniprotkb/E1B9T2" } ], "pmid": "" }, { "name": "neural crest cell migration", "id": "GO:0001755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001755", "evidence": [ { "database": "UniProtKB", "id": "E1B9T2", "url": "https://www.uniprot.org/uniprotkb/E1B9T2" } ], "pmid": "" }, { "name": "negative chemotaxis", "id": "GO:0050919", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050919", "evidence": [ { "database": "UniProtKB", "id": "E1B9T2", "url": "https://www.uniprot.org/uniprotkb/E1B9T2" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "E1B9T2", "url": "https://www.uniprot.org/uniprotkb/E1B9T2" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "E1B9T2", "url": "https://www.uniprot.org/uniprotkb/E1B9T2" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "E1B9T2", "url": "https://www.uniprot.org/uniprotkb/E1B9T2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9T2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 753, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9T2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9T2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9T2" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": 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"section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { 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"sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B9D0-1", "uniprot_ac": "E1B9D0", "uniprot_id": "E1B9D0_BOVIN", "mass": { "chemical_mass": 86011.0, "monoisotopic_mass": 86011.0 }, "refseq": {}, "gene_names": [ { "name": "CHPF2", "type": "recommended", "evidence": [ { "id": "E1B9D0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9D0" } ] } ], "protein_names": [ { "name": "Hexosyltransferase", "type": "recommended", "evidence": [ { "id": 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"E1B9D0", "url": "https://alphafold.ebi.ac.uk/entry/E1B9D0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014371", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014371", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008428", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008428", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051227", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051227", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YLNRVRM", "url": "https://omabrowser.org/oma/group/YLNRVRM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12369", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12369", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12369:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12369:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02434", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02434", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2022870", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022870", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9STM8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STM8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STM8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXD6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9D0", "url": "https://www.uniprot.org/uniprotkb/E1B9D0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9D0-1", "url": "https://www.uniprot.org/uniprotkb/E1B9D0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGPTAMRLSSVLALLRPALPLILGLSLGCSLSLLRVSWIQGEGDDPCVEAVGKAGGPQSLDSRTQLDQSDEDFKPRIVPYYRDPNKPYKKVLRTRYIQTELGSRERLLVAVLTSRATLSTLAVAVNRTVAHHFPRLLYFTGQRGARTPAGMQVVSHGDERPAWLMSETLRHLHTHFGADYDWFFIMQDDTYVQAPRLAALAGHLSINQDLYLGRAEEFIGAGEQARYCHGGFGYLLSRSLLLRLRPHLDGCRGDILSARPDEWLGRCLIDSLGIGCVSQHQGQRYRSFELAKNRDPETESSLAFLSAFAVHPVSEGTLMYRLHKRFSALELERAYSEIEQLQAQIRNLTALTPEGEAGLSWPLGLPAPFTPHSRFEVLGWDYFTEQHTFSCVDGAPKCPLQGASRADVGDAVETALEQLNRRYQPRLRFQKQRLLNGYRRFDPARGMEYTLDLLLEAVTQRGHRRALARRVSLLRPLSRVEILPMPYVTEATRVQLVLPLQAAEAAAAPTFLEAFAAGVLEPREHALLTLLLVYGPREGGRGAPDPFVGVKVAAAELERRYPGTRLAWLAVRAEAPSQVRLMDVVSKKHPVDTLFFLATVWTRPGPEVLNRCRMNAISGWQAFFPVHFQEFNPALAPQRPPPGAGPDPPSPPGADPARGAAGGGRFDRQASAEGCFYNADYLAARARLAADLAGQEEEEALEGLEVMDVFLRFSGLHLFRAVEPGLVQKFSLRDCSPRLSEELYHRCRLSNLEGLGGRAQLAMALFEQEQANST", "length": 775, "header": "tr|E1B9D0-1|E1B9D0_BOVIN Isoform 1 of Hexosyltransferase OS=Bos taurus OX=9913 GN=CHPF2 PE=3 SV=2 CANONICAL=E1B9D0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STM8-1", "url": "https://www.uniprot.org/uniprotkb/E1B9D0/entry#A0AAA9STM8-1", "sequence": { "sequence": "MAGPTAMRLSSVLALLRPALPLILGLSLGCSLSLLRVSWIQGEGDDPCVEAVGKAGGPQSLDSRTQLDQSDEDFKPRIVPYYRDPNKPYKKVLRTRYIQTELGSRERLLVAVLTSRATLSTLAVAVNRTVAHHFPRLLYFTGQRGARTPAGMQVVSHGDERPAWLMSETLRHLHTHFGADYDWFFIMQDDTYVQAPRLAALAGHLSINQDLYLGRAEEFIGAGEQARYCHGGFGYLLSRSLLLRLRPHLDGCRGDILSARPDEWLGRCLIDSLGIGCVSQHQAQIRNLTALTPEGEAGLSWPLGLPAPFTPHSRFEVLGWDYFTEQHTFSCVDGAPKCPLQGASRADVGDAVETALEQLNRRYQPRLRFQKQRLLNGYRRFDPARGMEYTLDLLLEAVTQRGHRRALARRVSLLRPLSRVEILPMPYVTEATRVQLVLPLQAAEAAAAPTFLEAFAAGVLEPREHALLTLLLVYGPREGGRGAPDPFVGVKVAAAELERRYPGTRLAWLAVRAEAPSQVRLMDVVSKKHPVDTLFFLATVWTRPGPEVLNRCRMNAISGWQAFFPVHFQEFNPALAPQRPPPGAGPDPPSPPGADPARGAAGGGRFDRQASAEGCFYNADYLAARARLAADLAGQEEEEALEGLEVMDVFLRFSGLHLFRAVEPGLVQKFSLRDCSPRLSEELYHRCRLSNLEGLGGRAQLAMALFEQEQANST", "length": 714, "header": "tr|A0AAA9STM8-1|E1B9D0_BOVIN Computationally mapped isoform of Hexosyltransferase OS=Bos taurus OX=9913 GN=CHPF2 PE=3 SV=1 CANONICAL=E1B9D0-1" }, "locus": { "chromosome": "4", "start_pos": 113816151, "end_pos": 113811976, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106547.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106547.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089779.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089779.1" } ] } }, { "isoform_ac": "A0AAA9SXD6-1", "url": "https://www.uniprot.org/uniprotkb/E1B9D0/entry#A0AAA9SXD6-1", "sequence": { "sequence": "MAGPTAMRLSSVLALLRPALPLILGLSLGCSLSLLRVSWIQGEGDDPCVEAVGKAGGPQSLDSRTQLDQSDEDFKPRIVPYYRDPNKPYKKVLRTRYIQTELGSRERLLVAVLTSRATLSTLAVAVNRTVAHHFPRLLYFTGQRGARTPAGMQDDTYVQAPRLAALAGHLSINQDLYLGRAEEFIGAGEQARYCHGGFGYLLSRSLLLRLRPHLDGCRGDILSARPDEWLGRCLIDSLGIGCVSQHQGQRYRSFELAKNRDPETESSLAFLSAFAVHPVSEGTLMYRLHKRFSALELERAYSEIEQLQAQIRNLTALTPEGEAGLSWPLGLPAPFTPHSRFEVLGWDYFTEQHTFSCVDGAPKCPLQGASRADVGDAVETALEQLNRRYQPRLRFQKQRLLNGYRRFDPARGMEYTLDLLLEAVTQRGHRRALARRVSLLRPLSRVEILPMPYVTEATRVQLVLPLQAAEAAAAPTFLEAFAAGVLEPREHALLTLLLVYGPREGGRGAPDPFVGVKVAAAELERRYPGTRLAWLAVRAEAPSQVRLMDVVSKKHPVDTLFFLATVWTRPGPEVLNRCRMNAISGWQAFFPVHFQEFNPALAPQRPPPGAGPDPPSPPGADPARGAAGGGRFDRQASAEGCFYNADYLAARARLAADLAGQEEEEALEGLEVMDVFLRFSGLHLFRAVEPGLVQKFSLRDCSPRLSEELYHRCRLSNLEGLGGRAQLAMALFEQEQANST", "length": 740, "header": "tr|A0AAA9SXD6-1|E1B9D0_BOVIN Computationally mapped isoform of Hexosyltransferase OS=Bos taurus OX=9913 GN=CHPF2 PE=3 SV=1 CANONICAL=E1B9D0-1" }, "locus": { "chromosome": "4", "start_pos": 113816151, "end_pos": 113811976, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120198.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120198.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088738.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088738.1" } ] } }, { "isoform_ac": "E1B9D0-1", "url": "https://www.uniprot.org/uniprotkb/E1B9D0/entry#E1B9D0-1", "sequence": { "sequence": "MAGPTAMRLSSVLALLRPALPLILGLSLGCSLSLLRVSWIQGEGDDPCVEAVGKAGGPQSLDSRTQLDQSDEDFKPRIVPYYRDPNKPYKKVLRTRYIQTELGSRERLLVAVLTSRATLSTLAVAVNRTVAHHFPRLLYFTGQRGARTPAGMQVVSHGDERPAWLMSETLRHLHTHFGADYDWFFIMQDDTYVQAPRLAALAGHLSINQDLYLGRAEEFIGAGEQARYCHGGFGYLLSRSLLLRLRPHLDGCRGDILSARPDEWLGRCLIDSLGIGCVSQHQGQRYRSFELAKNRDPETESSLAFLSAFAVHPVSEGTLMYRLHKRFSALELERAYSEIEQLQAQIRNLTALTPEGEAGLSWPLGLPAPFTPHSRFEVLGWDYFTEQHTFSCVDGAPKCPLQGASRADVGDAVETALEQLNRRYQPRLRFQKQRLLNGYRRFDPARGMEYTLDLLLEAVTQRGHRRALARRVSLLRPLSRVEILPMPYVTEATRVQLVLPLQAAEAAAAPTFLEAFAAGVLEPREHALLTLLLVYGPREGGRGAPDPFVGVKVAAAELERRYPGTRLAWLAVRAEAPSQVRLMDVVSKKHPVDTLFFLATVWTRPGPEVLNRCRMNAISGWQAFFPVHFQEFNPALAPQRPPPGAGPDPPSPPGADPARGAAGGGRFDRQASAEGCFYNADYLAARARLAADLAGQEEEEALEGLEVMDVFLRFSGLHLFRAVEPGLVQKFSLRDCSPRLSEELYHRCRLSNLEGLGGRAQLAMALFEQEQANST", "length": 775, "header": "tr|E1B9D0-1|E1B9D0_BOVIN Isoform 1 of Hexosyltransferase OS=Bos taurus OX=9913 GN=CHPF2 PE=3 SV=2 CANONICAL=E1B9D0-1" }, "locus": { "chromosome": "4", "start_pos": 113816151, "end_pos": 113811976, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019108.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019108.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019108.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019108.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-2022870", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022870", "resource": "Reactome", "description": "CS-GAG biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1L1RW56-1", "protein_name": "Hexosyltransferase", "gene_name": "CHPF2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRLAALLAALRPALPLVLGLSLGCSLSLLRASWSQGGGEELCLGAAGRAELPGVAQPEAAEAWPGQGHEDFRPRIVPYYRDPNKPYKKVLRTRYIQTELGFHERLFVAVLTSRATLNTLAVAVNKTIAHHFSRLLYFTGLRSAKVPHGMVLVAHGDERPIWLMYETMYYIHQHFGSDYDWFYIMQDDTYAQAEQVKALVTHLSINQDVYLGRAEEFIGGDEQARYCHGGFGYLLSRSLLLKLHPHLDSCRNEILSVRPDEWLGRCIIDFLGIACVSQLQGQHYRTYELAKNADPEKEEEEEFQAAIAVHPVSDMTLMYRLHKHFSRIQLERAYQEIQELQMQIRNLTSLTPAGEASLTWPVGINSPFLPKSRFEVISWDYFTEQHLFSCLDGSPKCELSGASKADVSDIIESALEQLNSRYQPLLRFSKRQLLNGYRRFDPTRGMEYTLDLLLEAVTQKGHSHVLVKRVSLVRPLSKVEIIPMPYVTEATRVQLVLPLTVQDLDFVSNFLDMYAMNTLDTHDNALLTLLFIYHPYDAQRVSQVDVFAGVKAMIGELEKRYTEVKIPWISVKTEVPSQVKLMDIVSKKHPVDTLFFLASVWTEINMEFLNRCRMNTISNWQVFFPVHFQEFNPALVYRGEQTASSSTDFLRDGHFDRHSFAEACFYNSDYMTARTKLAADILDRDEVLESMEVFDVFLHYSGLHLFRAVEPGLVQKYALRSCNPRLSEELYHRCVLSNLEGLASRSHLAMALFEQEQANST", "length": 760 }, "evidence": [ { "id": "E1B9D0", "url": "https://omabrowser.org/oma/group/E1B9D0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1Q679-1", "protein_name": "Hexosyltransferase", "gene_name": "chpf2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRLSSFLAVFRPALPLILGLSLGCSLSLLMVSWTQGDTDEACGDDLGNGRLVHNGHIRDLHNGQEGDGNEDFQPRIVPYHKDPNKPHKKVLRTRYIHTELGIRERLLVGILSSRATLNTLGVAVNKTVAHHFHRTFFFTGLRSAKAPHGMAVIAHGDDRPVWLMYETIRHLHQHHANEYDWFYLAQDDTYTQAERIMELVNHLSAGQDMYMGRAEEFIGGEERARYCHGGYGYLLSRSLLARLQPHLDSCRNDILSVRPDEWLGRCIIDYLGLSCVEKHQEMTYRYFELQKNVDPEREDSAQFKNAFTVHPISEPALMYRLHKRYNQIELDWTYAQIQHLQNQINNISELTPEGKAGATWPIGINPPFRPKTRFEVINWEYFTEEHIYSCGDSSPKCELRGADRADVSSVLETAVGRLNERYQPQLRFRKRRLLNGYRRFDPTRGMEYVLDLALEAFTQKGHSQVIAKRVNLLKPLSAVEIIPMPYVTEATRVQVILPVTAHDQDFVGNFLDMYVMNALDTHDNALLTFLFVYDPFDAQRVSQTDVFAGVKAMIGEVEKRYGDVKIPWISVKTEVPSQVKLMDIISKKHPVDTLFFLASVWTEVNADFLNRCRMNAISNWQVFFPIHFQEYSPALVYRDQQPSAASSFASETLRDGHFDRHVFEEACFYNADYMAARTKMAADILDNDELLESMDVYEIFVRYSGLHVFRAVEPALVQKYVHRECNPRFSEDIYHRCVLSNLEGLASRSHLAMALFEQEQANST", "length": 764 }, "evidence": [ { "id": "E1B9D0", "url": "https://omabrowser.org/oma/group/E1B9D0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1SSM9-1", "protein_name": "Hexosyltransferase", "gene_name": "CHPF2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRLSSLLALLRPALPLILGLSLGCSLSLLRVSWIQGEGEDPCVEAVGEPGGPQHPDSRTQLDQSDEDFKPRIVPYYRDPNKPYKKVLRTRYIQTELGSRERLLVAVLTSRATLSTLAVAVNRTVAHHFPRLLYFTGQRGARPPAGMQVVSHGDERPAWLMSETLRHLHTHFGADYDWFFIMQDDTYVQAPRLAALAGHLSINQDLYLGRTEEFIGAGEQARYCHGGFGYLLSRSLLLRLRPHLDGCRGDILSARPDEWLGRCLIDSLGIGCVSQHQGQQYRSFELAKNRDPEKEGSAAFLSAFAVHPVSEGTLMYRLHKRFSALELERAYSEIEQLQAQIRNLTVLTPEGEAGLSWPIGLPAPFTPRSRFEVLGWDYFTEQHTFSCADGAPKCPLQGASRADVGDAVETALEQLNRRYQPRLRFQKQRLLNGYRRFDPARGMEYTLDLLLEAVTQRGHRRALARRVSLLRPLSRVEILPMPYVTEATRVQLVLPLLVAEAAAAPAFLEAFAASVLEPREHALLTLLLVYGPREGGRGAPDPFLGVKAAAAELERRYPGTRLAWLAVRAEAPSQVRLMDVVSKKHPVDTLFFLTTVWTRPGPEVLNRCRMNAISGWQAFFPVHFQEFNPALAPQRSPPGPPGAGPDPPSPPGADPSRGAPVGGRFDRQASAEGCFYNADYLAARARLAGELAGQEEEEALEGLEVMDVFLRFSGLHLFRAVEPGLVQKFSLRDCSPRLSEELYHRCRLSNLEGLGGRAQLAMALFEQEQANST", "length": 772 }, "evidence": [ { "id": "E1B9D0", "url": "https://omabrowser.org/oma/group/E1B9D0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3UU43-1", "protein_name": "Chondroitin polymerizing factor 2, non-catalytic subunit", "gene_name": "Chpf2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRLSSLLALLRPVLPLILGLSLGCSLSLLRVSWIQGEGEDPCVEAVGKPGGPQNPDSKNGLDQGDEDFRPRIVPYYRDPNKPYKKVLRTRYIQTELGSRERLLVAVLTSRATLSTLAVAVNRTVAHHFPRLLYFTGQRGARAPAGMQVVSHGDERPAWLMSETLRHLHTHFGADYDWFFIMQDDTYVQAPRLAALAGHLSINQDLYLGHAEEFIGTGEQARYCHGGFGYLLSRSLLLRLRPHLDGCRGDILSARPDEWLGRCLIDTLGIGCVSQHQGQQYRSFELAKNRDPEKEESPAFLSAFAVHPVPEGTLMYRLHKRFSALELERAYSEIEQLQAQIRNLTVLTPEGEAGLSWPVGLPAPFTPHSRFEVLGWDYFTEQHTFACADGAPKCPLQGASRADVGDAVDTALEQLNRRYQPRLRFRKQRLLNGYRRFDPARGMEYTLDLLLEAVTQRGHRRSLARRVSLLRPLSRVEILPMPYVTEATRVQLVLPLLVAEAPAALAFLEAFAASVLEPREHALLTLLLVYGPREGRGGPDPFLGVKAAAAELERRYPGARLAWLAVRAEAPSQVRLMDVISKKHPVDTLFFLTTVWTRPGSEVLNRCRMNAISGWQAFFPVHFQEFNPALSPQRSPPGVPGADPPSPGVDPSRGAPVGGRFDRQASAEGCFYNADYLAARARLAGELAGQEEEEALEGLEVMDVFLRFSGLHLFRAVEPGLVQKFSLRDCSPRLSEELYHRCRLSNLEGLGARTQLAMALFEQEQANST", "length": 768 }, "evidence": [ { "id": "E1B9D0", "url": "https://omabrowser.org/oma/group/E1B9D0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P2E5-1", "protein_name": "Chondroitin polymerizing factor 2, non-catalytic subunit", "gene_name": "CHPF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRLSSLLALLRPALPLILGLSLGCSLSLLRVSWIQGEGEDPCVEAVGERGGPQNPDSRARLDQSDEDFKPRIVPYYRDPNKPYKKVLRTRYIQTELGSRERLLVAVLTSRATLSTLAVAVNRTVAHHFPRLLYFTGQRGARAPAGMQVVSHGDERPAWLMSETLRHLHTHFGADYDWFFIMQDDTYVQAPRLAALAGHLSINQDLYLGRAEEFIGAGEQARYCHGGFGYLLSRSLLLRLRPHLDGCRGDILSARPDEWLGRCLIDSLGVGCVSQHQGQQYRSFELAKNRDPEKEGSSAFLSAFAVHPVSEGTLMYRLHKRFSALELERAYSEIEQLQAQIRNLTVLTPEGEAGLSWPVGLPAPFTPHSRFEVLGWDYFTEQHTFSCADGAPKCPLQGASRADVGDALETALEQLNRRYQPRLRFQKQRLLNGYRRFDPARGMEYTLDLLLECVTQRGHRRALARRVSLLRPLSRVEILPMPYVTEATRVQLVLPLLVAEAAAAPAFLEAFAANVLEPREHALLTLLLVYGPREGGRGAPDPFLGVKAAAAELERRYPGTRLAWLAVRAEAPSQVRLMDVVSKKHPVDTLFFLTTVWTRPGPEVLNRCRMNAISGWQAFFPVHFQEFNPALSPQRSPPGPPGAGPDPPSPPGADPSRGAPIGGRFDRQASAEGCFYNADYLAARARLAGELAGQEEEEALEGLEVMDVFLRFSGLHLFRAVEPGLVQKFSLRDCSPRLSEELYHRCRLSNLEGLGGRAQLAMALFEQEQANST", "length": 772 }, "evidence": [ { "id": "E1B9D0", "url": "https://omabrowser.org/oma/group/E1B9D0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VYH2-1", "protein_name": "Hexosyltransferase", "gene_name": "Chpf", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MRRPFTALNRNHYFVIGLLLGLLLSWHIPEDIWEEECPEEAAENLLIERFGQEFEPHLNLINKPLAAKKPVKNVIRPRYYSSELGIREKLFIGVMTSQEHINTFATAFNRTTAHLVNKIKFFIYADSVKTNYKLKNIVGFTDTRESRRPFHVVKYIADNYLDEYDYFLLVPDTVYVDARKLVKLLYHMSITFDLYMGGARIGLDPSGGGASADGQSNEPPANEEEAPGASDRNYCSLEAGILLSSSVIRKMRNNLERCVRIGSTSDHSVNIGRCVKYASRVAGCQESFQGMRQFSYALDAPGRRHREFSELAKEEAFRNASTVYPVQTPEDFYRLHAYYSKHHLEKVQERGYALEQKSYRIANGSISNKILEIRWPLGVPPPSAPETRHDILTWQLLNGTHNFLPNGNAEHAVATLSRIEAQDFAKVLEIALQYAALKHPRLSYHSLHSAYRKFDATRGMDYQLHLNLQEGSGRSRRLVIKSFEVVKPLGRVEVVPSPYVTESTRIAMLVPAFEHQVPDALLFVEQYERICMQNQDNTFLLLIFMYRLESPSKGDEDPFKALKTLALDLSSKYKTDGSRIAWVSIRLPEQLSEPVDPQSWLLHASMYGPRQLLSLVVADLALPKLGLESLVLLATPGMVFKADFLNRVRMNTIQGFQVYAPIGFQMYPCRWAHFCRECDTCDVSQSSGYFDRHNHDVIAFYSRDYVQARKLLHPQGLPIIRSDLDIDQLLLQPGEETRPPGVESILDMFVAAQHSVHILRGVEPNLRFGQDVRNHLARGGTLPQSVPERCGREQCIHLASRKQIGDAIIRYEDKSILHK", "length": 819 }, "evidence": [ { "id": "E1B9D0", "url": "https://omabrowser.org/oma/group/E1B9D0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi cisterna membrane", "id": "GO:0032580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032580", "evidence": [ { "database": "UniProtKB", "id": "E1B9D0", "url": "https://www.uniprot.org/uniprotkb/E1B9D0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "acetylgalactosaminyltransferase activity", "id": "GO:0008376", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008376", "evidence": [ { "database": "UniProtKB", "id": "E1B9D0", "url": "https://www.uniprot.org/uniprotkb/E1B9D0" } ], "pmid": "" }, { "name": "N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity", "id": "GO:0050510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050510", "evidence": [ { "database": "UniProtKB", "id": "E1B9D0", "url": "https://www.uniprot.org/uniprotkb/E1B9D0" } ], "pmid": "" }, { "name": "glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "id": "GO:0047238", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047238", "evidence": [ { "database": "UniProtKB", "id": "E1B9D0", "url": "https://www.uniprot.org/uniprotkb/E1B9D0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "chondroitin sulfate proteoglycan biosynthetic process", "id": "GO:0050650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050650", "evidence": [ { "database": "UniProtKB", "id": "E1B9D0", "url": "https://www.uniprot.org/uniprotkb/E1B9D0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 348, "end_pos": 350, "annotation": "n_glycosylation_sequon" }, { "start_pos": 773, "end_pos": 775, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-1971487", "name": "Chondroitin polymerase complex transfers GalNAc to CS chain", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N783-1", "F6PU96-1", "E1B9D0-1", "E1BMM8-1" ], "evidence": [ { "id": "R-BTA-1971487", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1971487" } ] }, { "id": "R-BTA-1971491", "name": "Chondroitin polymerase complex transfers GlcA to CS chain", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N783-1", "F6PU96-1", "E1B9D0-1", "E1BMM8-1" ], "evidence": [ { "id": "R-BTA-1971491", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1971491" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "E1B9D0", "gene_name": "CHPF2", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "E1B9D0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9D0" } ] } ] }, { "uniprot_ac": "E1BMM8", "gene_name": "CHPF", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "E1BMM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMM8" } ] } ] }, { "uniprot_ac": "F1N783", "gene_name": "CHSY3", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F1N783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N783" } ] } ] }, { "uniprot_ac": "F6PU96", "gene_name": "CHSY1", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F6PU96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PU96" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9D0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 775, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9D0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9D0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 }, { "start_pos": 348, "end_pos": 350 }, { "start_pos": 773, "end_pos": 775 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BAD9-1", "uniprot_ac": "E1BAD9", "uniprot_id": "E1BAD9_BOVIN", "mass": { "chemical_mass": 34907.0, "monoisotopic_mass": 34907.0 }, "refseq": { "ac": "NP_001179338", "name": "carbonic anhydrase 5A, mitochondrial", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179338" }, "gene_names": [ { "name": "CA5A", "type": "recommended", "evidence": [ { "id": "E1BAD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAD9" } ] }, { "name": "CA5A", "type": "synonym", "evidence": [ { "id": "NP_001179338", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179338" } ] } ], "protein_names": [ { "name": "Carbonic anhydrase", "type": "recommended", "evidence": [ { "id": "E1BAD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAD9/entry#names_and_taxonomy" } ] }, { "name": "4.2.1.1", "type": "synonym", "evidence": [ { "id": "E1BAD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAD9/entry#names_and_taxonomy" } ] }, { "name": "carbonic anhydrase 5A, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001179338", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179338" } ] } ], "function": [ { "annotation": "Reversible hydration of carbon dioxide.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T217", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T217#function" }, { "database": "UniProtKB", "id": "RU367011", "url": "https://www.uniprot.org/uniprotkb/RU367011#function" }, { "database": "UniProtKB", "id": "A0A3Q1LWK4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWK4#function" }, { "database": "UniProtKB", "id": "E1BAD9", "url": "https://www.uniprot.org/uniprotkb/E1BAD9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAD9", "url": "https://www.uniprot.org/uniprotkb/E1BAD9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CA5A", "url": "https://www.uniprot.org/uniprotkb/E1BAD9", "locus": { "chromosome": "18", "start_pos": 13344980, "end_pos": 13368386, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010151", "url": "https://www.ensembl.org/id/ENSBTAG00000010151" } ] } } ], "crossref": [ { "id": "E1BAD9", "url": "https://alphafold.ebi.ac.uk/entry/E1BAD9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010151", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010151", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515359", "url": "https://www.ncbi.nlm.nih.gov/gene/515359", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001148", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001148", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018338", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018338", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023561", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023561", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036398", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036398", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515359", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515359", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EKAMVNN", "url": "https://omabrowser.org/oma/group/EKAMVNN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LWK4", "url": "https://www.orthodb.org/?gene=A0A3Q1LWK4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BAD9", "url": "https://www.orthodb.org/?gene=E1BAD9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18952", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18952", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18952:SF89", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18952:SF89", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00194", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00194", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1475029", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1475029", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179338", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10748", "url": "https://www.rhea-db.org/rhea/10748", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LWK4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWK4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWK4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T217", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T217", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T217-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T217-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKC0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKC0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAD9", "url": "https://www.uniprot.org/uniprotkb/E1BAD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAD9-1", "url": "https://www.uniprot.org/uniprotkb/E1BAD9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRPPVLGWSHLKSSGLSLLAKQIWGTLRSHLLRPARWCSQVPCAQRRRNDALHPVWKGPASVPGGTRQSPINIRWRDSVYDPQLQPLGVSYNAEACLYVWNTGYLFQVEFDDSTEGSGISGGPLENHYRLKQFHFHWGAVNEWGSEHTVDDRVYPAELHLVHWNAVKYQNYTDAVTGADGLAVVGVFLKLGARHEELQELVAVLPDIKHKDARAALGPFQPSCLLPACQDYWTYPGSLTTPPLSESVTWIIHKKPIEVAQDQLAAFRSLLFSVPGEEEKTMVNNYRPLQPLMNRKVRSSFQATHEGARL", "length": 310, "header": "tr|E1BAD9-1|E1BAD9_BOVIN Isoform 1 of Carbonic anhydrase OS=Bos taurus OX=9913 GN=CA5A PE=3 SV=1 CANONICAL=E1BAD9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWK4-1", "url": "https://www.uniprot.org/uniprotkb/E1BAD9/entry#A0A3Q1LWK4-1", "sequence": { "sequence": "MVRPPVLGWSHLKSSGLSLLAKQIWGTLRSHLLRPARWCSQVPCAQRRRNDALHPVWKGPASVPGGTRQSPINIRWRDSVYDPQLQPLGVSYNAEACLYVWNTGYLFQVEFDDSTEGSGISGGPLENHYRLKQFHFHWGAVNEWGSEHTVDDRVYPAELHLVHWNAVKYQNYTDAVTGADGLAVVGVFLKDARAALGPFQPSCLLPACQDYWTYPGSLTTPPLSESVTWIIHKKPIEVAQDQAKILEWVAIPSSRGSSQSWDQTLVSCTGSWPRFARSCFLCLVKKRRRW", "length": 290, "header": "tr|A0A3Q1LWK4-1|E1BAD9_BOVIN Computationally mapped isoform of Carbonic anhydrase OS=Bos taurus OX=9913 GN=CA5A PE=3 SV=3 CANONICAL=E1BAD9-1" }, "locus": { "chromosome": "18", "start_pos": 13368318, "end_pos": 13346067, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068215.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068215.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061809.3", "url": "https://www.ensembl.org/id/ENSBTAP00000061809.3" } ] } }, { "isoform_ac": "A0AAA9T217-1", "url": "https://www.uniprot.org/uniprotkb/E1BAD9/entry#A0AAA9T217-1", "sequence": { "sequence": "MVRPPVLGWSHLKSSGLSLLAKQIWGTLRSHLLRPARWCSQVPCAQRRRNDALHPVWKGPASVPGGTRQSPINIRWRDSVYDPQLQPLGVSYNAEACLYVWNTGYLFQVEFDDSTEGSGISGGPLENHYRLKQFHFHWGAVNEWGSEHTVDDRVYPAELHLVHWNAVKYQNYTDAVTGADGLAVVGVFLKLGARHEELQELVAVLPDIKHKDARAALGPFQPSCLLPACQDYWTYPGSLTTPPLSESVTWIIHKKPIEVAQDQNFPGKNTGVGSHSLLQGIFPILGSNSGLLHWQLAAFRSLLFSVPGEEEKTMVNNYRPLQPLMNRKVRSSFQATHEGARL", "length": 342, "header": "tr|A0AAA9T217-1|E1BAD9_BOVIN Computationally mapped isoform of Carbonic anhydrase OS=Bos taurus OX=9913 GN=CA5A PE=3 SV=1 CANONICAL=E1BAD9-1" }, "locus": { "chromosome": "18", "start_pos": 13368318, "end_pos": 13345984, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134591.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134591.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092839.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092839.1" } ] } }, { "isoform_ac": "A0AAA9TKC0-1", "url": "https://www.uniprot.org/uniprotkb/E1BAD9/entry#A0AAA9TKC0-1", "sequence": { "sequence": "MVRPPVLGWSHLKSSGLSLLAKQIWGTLRSHLLRPARWCSQVPCAQRRRNDALHPVWKGPASVPGGTRQSPINIRWRDSVYDPQLQPLGVSYNAEACLYVWNTGYLFQVEFDDSTEGSAALGSLERCEIPELHRCRDRSRWLGGGRCIFKGRTSSPGPLPALLPAACLPGLLDIPRLPDHAATVRVGHLDHPQEAHRGGSGPGKNTGVGSHSLLQGIFPILGSNSGLLHWQLAAFRSLLFSVPGEEEKTMVNNYRPLQPLMNRKVRSSFQATHEGARL", "length": 278, "header": "tr|A0AAA9TKC0-1|E1BAD9_BOVIN Computationally mapped isoform of Carbonic anhydrase OS=Bos taurus OX=9913 GN=CA5A PE=3 SV=2 CANONICAL=E1BAD9-1" }, "locus": { "chromosome": "18", "start_pos": 13368318, "end_pos": 13345984, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128182.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128182.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098896.2", "url": "https://www.ensembl.org/id/ENSBTAP00000098896.2" } ] } }, { "isoform_ac": "E1BAD9-1", "url": "https://www.uniprot.org/uniprotkb/E1BAD9/entry#E1BAD9-1", "sequence": { "sequence": "MVRPPVLGWSHLKSSGLSLLAKQIWGTLRSHLLRPARWCSQVPCAQRRRNDALHPVWKGPASVPGGTRQSPINIRWRDSVYDPQLQPLGVSYNAEACLYVWNTGYLFQVEFDDSTEGSGISGGPLENHYRLKQFHFHWGAVNEWGSEHTVDDRVYPAELHLVHWNAVKYQNYTDAVTGADGLAVVGVFLKLGARHEELQELVAVLPDIKHKDARAALGPFQPSCLLPACQDYWTYPGSLTTPPLSESVTWIIHKKPIEVAQDQLAAFRSLLFSVPGEEEKTMVNNYRPLQPLMNRKVRSSFQATHEGARL", "length": 310, "header": "tr|E1BAD9-1|E1BAD9_BOVIN Isoform 1 of Carbonic anhydrase OS=Bos taurus OX=9913 GN=CA5A PE=3 SV=1 CANONICAL=E1BAD9-1" }, "locus": { "chromosome": "18", "start_pos": 13368318, "end_pos": 13345984, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013397.5", "url": "https://www.ensembl.org/id/ENSBTAT00000013397.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013397.4", "url": "https://www.ensembl.org/id/ENSBTAP00000013397.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:515359", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515359", "resource": "KEGG Pathway" }, { "id": "R-BTA-1475029", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1475029", "resource": "Reactome", "description": "Reversible hydration of carbon dioxide" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2RAR3-1", "protein_name": "Carbonic anhydrase", "gene_name": "CA5A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLRAPLSCRGHVTSSAFSGLVRQRWGTLRGHWLRPERWCVQAPCGPRRRNNAVHPLWKDPASSPGGTRPSPINIRWRDSVYDPRLQPLSVSYDAASCLHVWNTGYLLQVEFDDSTDWSGISGGPLENPYRLKQFHFHWGAVDEWGSEHTVEDHAYPAELHLVHWNAVKYQNYREAATGEHGLAVIGVFLKLGARHEALQELLEVLPDIKHKDSRAALGPFQPSCLLPTCRDYWTYPGSLTTPPLSESVTWIIYKKPIEVAQDQLAAFRTLLFSALGEKEEAMVNNYRPLQPLMKRKVRSSFQTPEDGPAA", "length": 310 }, "evidence": [ { "id": "E1BAD9", "url": "https://omabrowser.org/oma/group/E1BAD9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P23589-1", "protein_name": "Carbonic anhydrase 5A, mitochondrial", "gene_name": "Ca5a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRRDPRKPLAILRHVGLLCATGPQRWRFQHSCAEEHSNCARHPLWTGPVSSAEGTRQSPINIQWKDSVYDPQLAPLRVSYDAASCRYLWNTGYFFQVEFDDSCEDSGISGGPLGNHYRLKQFHFHWGATDEWGSEHAVDGHTYPAELHLVHWNSTKYENYKKASVGENGLAVIGVFLKLGAHHQALQKLVDVLPEVRHKDTQVAMGPFDPSCLLPACRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSTFRTLLFSGRGEEEDVMVNNYRPLQPLRDRKLRSSFRLDRTKMRS", "length": 299 }, "evidence": [ { "id": "E1BAD9", "url": "https://omabrowser.org/oma/group/E1BAD9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P35218-1", "protein_name": "Carbonic anhydrase 5A, mitochondrial", "gene_name": "CA5A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLGRNTWKTSAFSFLVEQMWAPLWSRSMRPGRWCSQRSCAWQTSNNTLHPLWTVPVSVPGGTRQSPINIQWRDSVYDPQLKPLRVSYEAASCLYIWNTGYLFQVEFDDATEASGISGGPLENHYRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVIGVFLKLGAHHQTLQRLVDILPEIKHKDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATNEGTRS", "length": 305 }, "evidence": [ { "id": "E1BAD9", "url": "https://omabrowser.org/oma/group/E1BAD9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P43165-1", "protein_name": "Carbonic anhydrase 5A, mitochondrial", "gene_name": "Ca5a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLRAKMLGRGPYKPLAILRHMGPLCATRPQHWRFQHSYAEKHSNCARHPLWTGPVSSPGGTQQSPINIQWTDSVYDPKLAPLRVSYDAASCRYLWNTGYFFQVEFDDSCEESGISGGPLGNHYRLKQFHFHWGATDEWGSEHMVDGHAYPAELHLVHWNSMKYENYKKATTGENGLAVIGVFLKLGAHHEALQRLVDILPEVRHKDTQVTMGPFDPSCLLPACRDYWTYPGSLTTPPLAESVTWIVHKMPIEVSPSQLSTFRTLLFSGRGEDEEVMVNNFRPLQPLRGRNVRSSFQVPRVGTKS", "length": 304 }, "evidence": [ { "id": "E1BAD9", "url": "https://omabrowser.org/oma/group/E1BAD9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1BAD9", "url": "https://www.uniprot.org/uniprotkb/E1BAD9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BAD9", "url": "https://www.uniprot.org/uniprotkb/E1BAD9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BAD9", "url": "https://www.uniprot.org/uniprotkb/E1BAD9" } ], "pmid": "" }, { "name": "carbonate dehydratase activity", "id": "GO:0004089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004089", "evidence": [ { "database": "UniProtKB", "id": "E1BAD9", "url": "https://www.uniprot.org/uniprotkb/E1BAD9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10748", "name": "", "equation": "hydrogencarbonate + H(+) = CO2 + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N5D1-1", "G3MX64-1", "E1BAD9-1", "E1BHA4-1", "F1MBS0-1", "F1MPL2-1", "Q95323-1", "P00921-1", "P18915-1", "Q1LZA1-1", "Q3SZX4-1", "F1N0H3-1", "E1BPA4-1", "A0A0A0MP99-1", "A0A3Q1LYT6-1" ], "evidence": [ { "id": "10748", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10748" } ] }, { "id": "R-BTA-1475028", "name": "Carbonic anhydrase dehydrates bicarbonate (mitochondria)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N5D1-1", "E1BAD9-1" ], "evidence": [ { "id": "R-BTA-1475028", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1475028" } ] }, { "id": "R-BTA-1475032", "name": "Carbonic anhydrase hydrates carbon dioxide (mitochondria)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N5D1-1", "E1BAD9-1" ], "evidence": [ { "id": "R-BTA-1475032", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1475032" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0A0MP99", "gene_name": "LOC100847874", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "A0A0A0MP99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MP99" } ] }, { "ec_number": "4.2.1.69", "activity": "urea = cyanamide + H2O.", "evidence": [ { "id": "A0A0A0MP99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MP99" } ] }, { "ec_number": "4.2.1.69", "activity": "", "evidence": [ { "id": "A0A0A0MP99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MP99" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "A0A0A0MP99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MP99" } ] } ] }, { "uniprot_ac": "A0A3Q1LYT6", "gene_name": "LOC784254", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "A0A3Q1LYT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYT6" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYT6" } ] } ] }, { "uniprot_ac": "E1BAD9", "gene_name": "CA5A", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "E1BAD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAD9" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "E1BAD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAD9" } ] } ] }, { "uniprot_ac": "E1BHA4", "gene_name": "CA7", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "E1BHA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHA4" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "E1BHA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHA4" } ] } ] }, { "uniprot_ac": "E1BPA4", "gene_name": "CA9", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "E1BPA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA4" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "E1BPA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA4" } ] } ] }, { "uniprot_ac": "F1MBS0", "gene_name": "CA6", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "F1MBS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBS0" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "F1MBS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBS0" } ] } ] }, { "uniprot_ac": "F1MPL2", "gene_name": "CA12", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "F1MPL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPL2" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "F1MPL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPL2" } ] } ] }, { "uniprot_ac": "F1N0H3", "gene_name": "CA2", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "F1N0H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0H3" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "F1N0H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0H3" } ] } ] }, { "uniprot_ac": "F1N5D1", "gene_name": "CA5B", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "F1N5D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5D1" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "F1N5D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5D1" } ] } ] }, { "uniprot_ac": "G3MX64", "gene_name": "CA13", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "G3MX64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX64" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "G3MX64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX64" } ] } ] }, { "uniprot_ac": "P00921", "gene_name": "CA2", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "P00921", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00921" } ] }, { "ec_number": "4.2.1.69", "activity": "urea = cyanamide + H2O.", "evidence": [ { "id": "P00921", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00921" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "P00921", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00921" } ] } ] }, { "uniprot_ac": "P18915", "gene_name": "CA6", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "P18915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P18915" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "P18915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P18915" } ] } ] }, { "uniprot_ac": "Q1LZA1", "gene_name": "CA1", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "Q1LZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZA1" } ] }, { "ec_number": "4.2.1.69", "activity": "urea = cyanamide + H2O.", "evidence": [ { "id": "Q1LZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZA1" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "Q1LZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZA1" } ] } ] }, { "uniprot_ac": "Q3SZX4", "gene_name": "CA3", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "Q3SZX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZX4" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "Q3SZX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZX4" } ] } ] }, { "uniprot_ac": "Q95323", "gene_name": "CA4", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "Q95323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95323" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "Q95323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95323" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAD9" }, { "id": "PS51144", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51144" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Alpha-carbonic anhydrase", "eco_id": "ECO_0000259", "start_pos": 23, "end_pos": 301, "start_aa": "Gln", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "4.2.1.1", "ec_name": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "4.2.1.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1" }, { "id": "4.2.1.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=4.2.1.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 171, "end_pos": 173 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B7S8-1", "uniprot_ac": "E1B7S8", "uniprot_id": "E1B7S8_BOVIN", "mass": { "chemical_mass": 61273.0, "monoisotopic_mass": 61273.0 }, "refseq": { "ac": "XP_002687915", "name": "acrosin-binding protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687915" }, "gene_names": [ { "name": "ACRBP", "type": "recommended", "evidence": [ { "id": "E1B7S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S8" } ] }, { "name": "ACRBP", "type": "synonym", "evidence": [ { "id": "XP_002687915", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687915" } ] } ], "protein_names": [ { "name": "Acrosin-binding protein", "type": "recommended", "evidence": [ { "id": "E1B7S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S8/entry#names_and_taxonomy" } ] }, { "name": "Acrosin-binding protein, 60 kDa form", "type": "synonym", "evidence": [ { "id": "E1B7S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S8/entry#names_and_taxonomy" } ] }, { "name": "Proacrosin-binding protein sp32", "type": "synonym", "evidence": [ { "id": "E1B7S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S8/entry#names_and_taxonomy" } ] }, { "name": "acrosin-binding protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002687915", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687915" } ] } ], "function": [ { "annotation": "Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation.", "evidence": [ { "database": "UniProtKB", "id": "E1B7S8", "url": "https://www.uniprot.org/uniprotkb/E1B7S8#function" }, { "database": "UniProtKB", "id": "ARBA00045517", "url": "https://www.uniprot.org/uniprotkb/ARBA00045517#function" }, { "database": "UniProtKB", "id": "A0AAA9TFG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFG7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7S8", "url": "https://www.uniprot.org/uniprotkb/E1B7S8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACRBP", "url": "https://www.uniprot.org/uniprotkb/E1B7S8", "locus": { "chromosome": "5", "start_pos": 103794369, "end_pos": 103786572, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034246", "url": "https://www.ensembl.org/id/ENSBTAG00000034246" } ] } } ], "crossref": [ { "id": "E1B7S8", "url": "https://alphafold.ebi.ac.uk/entry/E1B7S8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034246", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034246", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515434", "url": "https://www.ncbi.nlm.nih.gov/gene/515434", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515434", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515434", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YDEEPVW", "url": "https://omabrowser.org/oma/group/YDEEPVW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7S8", "url": "https://www.orthodb.org/?gene=E1B7S8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21362", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21362", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21362:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21362:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07222", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07222", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002687915", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687915", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TFG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7S8", "url": "https://www.uniprot.org/uniprotkb/E1B7S8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7S8-1", "url": "https://www.uniprot.org/uniprotkb/E1B7S8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRHLAAGSFLSLLRVLLLPLAPAPAQDSASTSTPGSPLSPTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSDLPYASWFESFCQFTQYRCSNHVYYAKRVRCSQPVSILSPNTLKEVDSSPEVPPPTTATSPKSSHVTATERQVFQPWPERLNSNVEELLQSSLSLGGQEQGQEPKQEQGQEHKQERGQEHKQEEGQEQEEQEEEQEEEKQEGQGTEEALESVSRLQADPEPKFRSELVSSNPFSFTPRVREVESTPMLMENLQELIRSAQEMNEMNDVYDGETIWRSQSPGSLLQLPHVEALLTLCYSIVENTCVITPTAKAWQYLENEILGFGISVCDSLGRRHLAACTLCDFCSLKLEQCHSEANLQRQQCDSSHKTPFVSPLLASQSMTIGTQIGSLKSGRFYGLDLYGGLRMDFWCARLATKGCEDNRVASWLQTEFLSFQDGDFPTRICDTEYVQYPNYCAFKSQQCMMRNRDRKVSRMRCLQNETYTVLTPDKSEDLVLRWSQEFSTLTLGQAG", "length": 542, "header": "tr|E1B7S8-1|E1B7S8_BOVIN Isoform 1 of Acrosin-binding protein OS=Bos taurus OX=9913 GN=ACRBP PE=4 SV=2 CANONICAL=E1B7S8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TFG7-1", "url": "https://www.uniprot.org/uniprotkb/E1B7S8/entry#A0AAA9TFG7-1", "sequence": { "sequence": "MRHLAAGSFLSLLRVLLLPLAPAPAQDSASTSTPGSPLSPTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSDLPYASWFESFCQFTQYRCSNHVYYAKRVRCSQPVSILSPNTLKEVDSSPEVPPPTTATSPKSSHVTATERQVFQPWPERLNSNVEELLQSSLSLGGQEQGQEPKQEQGQEHKQERGQEHKQEEGQEQEEQEEEQEEEKQEGQGTEEALESVSRLQADPEPKFRSELVSSNPFSFTPRVREVESTPMLMENLQELIRSAQEMNEMNDVYDGETIWRSQSPGSLLQLPHVEALLTLCYSIVENTCVITPTAKAWQYLENEILGFGISVCDSLGRRHLAACTLCDFCSLKLEQCHSEANLQRQQCDSSHKTPFVSPLLASQSMTIGTQIGSLKSGRFYGLDLYGGLRMDFWCARLATKGCEDNRVASWLQTEFLSFQDGDFPTRVSRMRCLQNETYTVLTPDKSEDLVLRWSQEFSTLTLGQAG", "length": 514, "header": "tr|A0AAA9TFG7-1|E1B7S8_BOVIN Computationally mapped isoform of Acrosin-binding protein OS=Bos taurus OX=9913 GN=ACRBP PE=4 SV=1 CANONICAL=E1B7S8-1" }, "locus": { "chromosome": "5", "start_pos": 103794133, "end_pos": 103786644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125545.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125545.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094914.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094914.1" } ] } }, { "isoform_ac": "E1B7S8-1", "url": "https://www.uniprot.org/uniprotkb/E1B7S8/entry#E1B7S8-1", "sequence": { "sequence": "MRHLAAGSFLSLLRVLLLPLAPAPAQDSASTSTPGSPLSPTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSDLPYASWFESFCQFTQYRCSNHVYYAKRVRCSQPVSILSPNTLKEVDSSPEVPPPTTATSPKSSHVTATERQVFQPWPERLNSNVEELLQSSLSLGGQEQGQEPKQEQGQEHKQERGQEHKQEEGQEQEEQEEEQEEEKQEGQGTEEALESVSRLQADPEPKFRSELVSSNPFSFTPRVREVESTPMLMENLQELIRSAQEMNEMNDVYDGETIWRSQSPGSLLQLPHVEALLTLCYSIVENTCVITPTAKAWQYLENEILGFGISVCDSLGRRHLAACTLCDFCSLKLEQCHSEANLQRQQCDSSHKTPFVSPLLASQSMTIGTQIGSLKSGRFYGLDLYGGLRMDFWCARLATKGCEDNRVASWLQTEFLSFQDGDFPTRICDTEYVQYPNYCAFKSQQCMMRNRDRKVSRMRCLQNETYTVLTPDKSEDLVLRWSQEFSTLTLGQAG", "length": 542, "header": "tr|E1B7S8-1|E1B7S8_BOVIN Isoform 1 of Acrosin-binding protein OS=Bos taurus OX=9913 GN=ACRBP PE=4 SV=2 CANONICAL=E1B7S8-1" }, "locus": { "chromosome": "5", "start_pos": 103794133, "end_pos": 103786644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048539.6", "url": "https://www.ensembl.org/id/ENSBTAT00000048539.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045557.3", "url": "https://www.ensembl.org/id/ENSBTAP00000045557.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 148, "start_aa": "Thr", "end_pos": 148, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr148", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 33, "start_aa": "Thr", "end_pos": 33, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr33", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:515434", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515434", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7H8Q6-1", "protein_name": "Acrosin-binding protein", "gene_name": "Acrbp", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MMKLAAGFLLLLLEVRLLPVTPLLAEETSSASSPGSPLTSTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSDLPYASWFESFCQFAQYRCSNHVYYAKRVRCSQPVSILSPNTLKEVDSSAEAAPTTMTSAMASHVTATERQAFQAWPERLNNNVEELLQSSLSLGGKEQQSSRKQGQEQHKQEQVQEHKQEEGQEQEEQEEEEEEEEAKQEEGQGTEEGLESVSSLQSDPEPKFQSDSLSSNPSSFTPRVREVDSPPLMMENIQELIRSAQEMDEMNKLYDNSWRSQSTGSLLQLPHTETMMVLCYSIMENTCTMTPTAKAWSYMEEEILGFGDSVCDSLGRRHTAACPLCAFCSLKLEQCHAEGNVLRQRCDATHKIPFISPFLSSQSISTGNQARIPEKGRFAGLDMYGGLSSDFWCNRLAMKGCEDDRVSNWLKAEFLSFQDGDLPTKICDTDYVQYPNYCSFKSQQCLMRNQNRNLSRMRCMLNENYNVLSPAKSEEVILRWNQEFNALALGQFG", "length": 541 }, "evidence": [ { "id": "E1B7S8", "url": "https://omabrowser.org/oma/group/E1B7S8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q29016-1", "protein_name": "Acrosin-binding protein", "gene_name": "ACRBP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRQLAAGSLLSLLKVLLLPLAPAPAQDANSASTPGSPLSPTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSDLPYASWFESFCQFTQYRCSNHVYYAKRVRCSQPVSILSPNSLKEVDTSSEVPITTMTSPVSSHITATGRQVFQPWPERLNNNVEELLQSSLSLGGQEQGQEHKQEHKQEQGQEHKQDEGQEQEEQEEEQEEEGKQEEGQGTEESLEAMSGLQADSEPKFQSEFVSSNPFSFTPRVREVESTPMMMENIQELIRSAQEMDEMGDVYEEENIWRAQSPGSLLQLPHVDALLVLCYSIVENTCVITPTAKAWQYLEDETLGFGKSVCDSLGRRHLAACSLCDFCSLKLEQCHSETNLQRQQCDNSHKTPFISPLLASQSMSIGTQIGTLKSGRFYGLDLYGGLRMDFWCARLATKGCEDNRVASWLQTEFLSFQDGDFPTKICDTEYVQYPNYCAFKSQQCMMRNRDRKVSRMRCLQNETYTVLTQAKSEDLVLRWSQEFSTLTLGQAG", "length": 539 }, "evidence": [ { "id": "E1B7S8", "url": "https://omabrowser.org/oma/group/E1B7S8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3V140-1", "protein_name": "Acrosin-binding protein", "gene_name": "Acrbp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMNLAAGFLLMLLEVLLLPGTPLSAEESPASTPGSPLSSTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSDLPYASWFESFCQFAQYRCSNHVYYAKRVRCSQPVSILSPNTLKEVESSAEVPPTSMTTPIVSHATATEHQAFQPWPERLNNNVEELLQSSLSLGGKDQQSSRRPGQEQRKQEQIQEHKLEEAQEQEEQEEEEEEEEAKQEEGQGTEAGLESVSRLQSDSEPKFQSQSLSSNPSFFTPRVREVESAPLMMKNIQELIRSAQEMDEMNELYDDSWRSQSTGSLQQLPHMETLMVLCYSIMENTCTMTPTAKAWSYMEEEILGFGDSVCDNLGRRHTAACPLCAFCSLKLEQCHSEASVLRQKCDASHKIPFISPLLSAQSISTGNQARIPDKGRFAGLEMYGGLSSEFWCNRLAMKGCEDDRVSNWLKAEFLSFQEGDFPTKICDTNYIQYPNYCSFKSQQCLLRNQNRKMSRMRCMLNERYNVLSLAKSEEVILRWSQEFSTLAIGQFG", "length": 540 }, "evidence": [ { "id": "E1B7S8", "url": "https://omabrowser.org/oma/group/E1B7S8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6AY33-1", "protein_name": "Acrosin-binding protein", "gene_name": "Acrbp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKLAASFLLMLLEVLLLPETPLSAEEALASTPGSPLSSTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSDLPYASWFESFCQFAQYRCSNHVYYAKRVRCSQPVSILSPNTLKEVESSAEVPLTSVTTPIVSRATATEHQAFQPWPERLNNNVEELLQSSLSLGGKEQQSSRKLGLEQQHKQEQIQEHKLEEAQEQEEQEEEEEEEEAKQEEGQGTEEGLDSVSRLQSDSEPKFQSKSLSSNPSFFTPRVREVESAPLMMENIQELIRSAQEMDEMNELYDDSWRSQSTGSLQQLPHTETLMVLCYSIMENTCTMTPTAKAWSYMEEEILGFGDSVCDNLGRRHTAACPLCAFCSLKLEQCHSEASVLRQQCDASHKIPFISPLLSAQSISTGNQAKIPEKGRFAGLEMYGGLSSEFWCNRLALKGCEDDRVANWLKAEFLSFQDGDLPTKICDTNYVQYPNYCSFKSQQCLLKNQNRKMSRMKCMLNEKYHVLSPAKGEEVILRWSQEFNTLTLGQFG", "length": 540 }, "evidence": [ { "id": "E1B7S8", "url": "https://omabrowser.org/oma/group/E1B7S8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8NEB7-1", "protein_name": "Acrosin-binding protein", "gene_name": "ACRBP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRKPAAGFLPSLLKVLLLPLAPAAAQDSTQASTPGSPLSPTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSNLPYASWFESFCQFTHYRCSNHVYYAKRVLCSQPVSILSPNTLKEIEASAEVSPTTMTSPISPHFTVTERQTFQPWPERLSNNVEELLQSSLSLGGQEQAPEHKQEQGVEHRQEPTQEHKQEEGQKQEEQEEEQEEEGKQEEGQGTKEGREAVSQLQTDSEPKFHSESLSSNPSSFAPRVREVESTPMIMENIQELIRSAQEIDEMNEIYDENSYWRNQNPGSLLQLPHTEALLVLCYSIVENTCIITPTAKAWKYMEEEILGFGKSVCDSLGRRHMSTCALCDFCSLKLEQCHSEASLQRQQCDTSHKTPFVSPLLASQSLSIGNQVGSPESGRFYGLDLYGGLHMDFWCARLATKGCEDVRVSGWLQTEFLSFQDGDFPTKICDTDYIQYPNYCSFKSQQCLMRNRNRKVSRMRCLQNETYSALSPGKSEDVVLRWSQEFSTLTLGQFG", "length": 543 }, "evidence": [ { "id": "E1B7S8", "url": "https://omabrowser.org/oma/group/E1B7S8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "E1B7S8", "url": "https://www.uniprot.org/uniprotkb/E1B7S8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "fertilization", "id": "GO:0009566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009566", "evidence": [ { "database": "UniProtKB", "id": "E1B7S8", "url": "https://www.uniprot.org/uniprotkb/E1B7S8" } ], "pmid": "" }, { "name": "acrosome assembly", "id": "GO:0001675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001675", "evidence": [ { "database": "UniProtKB", "id": "E1B7S8", "url": "https://www.uniprot.org/uniprotkb/E1B7S8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 511, "end_pos": 513, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7S8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 542, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7S8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7S8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 33, 148 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 511, "end_pos": 513 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B8R7-1", "uniprot_ac": "E1B8R7", "uniprot_id": "E1B8R7_BOVIN", "mass": { "chemical_mass": 130304.0, "monoisotopic_mass": 130304.0 }, "refseq": { "ac": "XP_010819173", "name": "BLOC-2 complex member HPS5 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819173" }, "gene_names": [ { "name": "HPS5", "type": "recommended", "evidence": [ { "id": "E1B8R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R7" } ] }, { "name": "HPS5", "type": "synonym", "evidence": [ { "id": "XP_010819173", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819173" } ] } ], "protein_names": [ { "name": "Hermansky-Pudlak syndrome 5 protein homolog", "type": "recommended", "evidence": [ { "id": "E1B8R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R7/entry#names_and_taxonomy" } ] }, { "name": "BLOC-2 complex member HPS5 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010819173", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819173" } ] } ], "function": [ { "annotation": "May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins.", "evidence": [ { "database": "UniProtKB", "id": "E1B8R7", "url": "https://www.uniprot.org/uniprotkb/E1B8R7#function" }, { "database": "UniProtKB", "id": "ARBA00057536", "url": "https://www.uniprot.org/uniprotkb/ARBA00057536#function" }, { "database": "UniProtKB", "id": "A0AAA9TZG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZG4#function" }, { "database": "UniProtKB", "id": "PIRNR037475", "url": "https://www.uniprot.org/uniprotkb/PIRNR037475#function" }, { "database": "UniProtKB", "id": "A0AAA9TYV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYV5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8R7", "url": "https://www.uniprot.org/uniprotkb/E1B8R7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HPS5", "url": "https://www.uniprot.org/uniprotkb/E1B8R7", "locus": { "chromosome": "29", "start_pos": 26399099, "end_pos": 26355992, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005147", "url": "https://www.ensembl.org/id/ENSBTAG00000005147" } ] } } ], "crossref": [ { "id": "E1B8R7", "url": "https://alphafold.ebi.ac.uk/entry/E1B8R7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005147", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005147", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510165", "url": "https://www.ncbi.nlm.nih.gov/gene/510165", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035431", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035431", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510165", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510165", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1B8R7", "url": "https://www.orthodb.org/?gene=E1B8R7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23287", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23287", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23287:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23287:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF23756", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23756", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23758", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23758", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010819173", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819173", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SN64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN64-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYV5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZG4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZG4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8R7", "url": "https://www.uniprot.org/uniprotkb/E1B8R7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8R7-1", "url": "https://www.uniprot.org/uniprotkb/E1B8R7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTFVPVIPESYSHVLAEFESLDPLLSALRLDSTRLKCTSIAVSRKWLALGSSGGGLNLIQKEGWKHRLFLSHREGAISQIACCLHDDDYVAVATSQGLVVVWELNQERRGKPERIYVSSEHKGRKITALCWDTAILRIFVGDHLGKVSAIKLNTSKQAKAAAAFVMFPVQTITTVDSCVVQLDYLDGRLLVSSLTRSFLCDTEREKFWKIGNKERDGEYGACFFPGRCSAGQQPLIYCARPGSRMWEVNFDGEVLSTHQFKKLLSSPPLPVINLRSEPQYDHTIGSSQSLSFPKLLHISEHCVLTWTERGIYIFIPQNVQVLLWSEVKDIQDVAVCKNELFCLHLNGKVSHLSLLSVERCVERLLRRGLWNLAARTCCLFQNSVIASRGRKTLTVDKLEHLKSQLDLTTYGDLISQLEELILKLEPLDSACSSRRSSISSHESFSILDSGIYRIINSRRGSQSDEDSCSLHSQTLSEDERLKEFASHQEEDQPDHCCGSQGSEGMKNYYSFGGHCLHFSMFKYSCGRTLEKRLIETLNFLYDYGDSGIPLSFRSPSPLVSLQAVKESVSSFVRKTTEKIGTLHTSPDLKVRQEPRGDEQSCEEDVSPVTCPKEEDIEGKEEITSHPPEEDKFQELTMATAEAMSKLQDPLVLFEPKSLRMVLREWLSQLEKTFAVKDFSGISDTGSSSVESNQDMQLLDESRKGILDEEYEKEERDSLGNEETIDQTACESVNSLREPLDDDVFQICSPWSIADSLQKDLAELTTLCLELSVLNSEIKSASGHGDHTLQQCSLEMLTCQFLKKYFFLLDLKRAKESIKLSYPKSPCVWDTFIEGLKEMVSSSPTHIKMEEGDLPTRLKLLEDSVPFDSPLLIAYAARLYEKFGESALRSLIRFYPSILPSDVMQLCHHNPVQFLTYLDSLVKSRPEDQRPSFLESLLQPESLRLDWLLLAVSHDAPPSTSTMDDEGNPRPHSHLFSWGYSQLILHLIKLPADFTTKEKMTDICRSHGFWPGYLILCLELERRREAFTNIVYLNDMSLMEGDNGWIPETVEEWKLLLHLVQNTSTKPAPQQSPDGNFSDGPSPITVENVALLLAKAMGPDRAWSLLQECGLTLDLSERFTRTCDILRIAEKRQRALIQSMLEKCDRFLWSQQA", "length": 1152, "header": "tr|E1B8R7-1|E1B8R7_BOVIN Isoform 1 of Hermansky-Pudlak syndrome 5 protein homolog OS=Bos taurus OX=9913 GN=HPS5 PE=3 SV=3 CANONICAL=E1B8R7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SN64-1", "url": "https://www.uniprot.org/uniprotkb/E1B8R7/entry#A0AAA9SN64-1", "sequence": { "sequence": "MNIDNFSLQLSLRPSFLESLLQPESLRLDWLLLAVSHDAPPSTSTMDDEGNPRPHSHLFSWGYSQLILHLIKLPADFTTKEKMTDICRSHGFWPGYLILCLELERRREAFTNIVYLNDMSLMEGDNGWIPETVEEWKLLLHLVQNTSTKPAPQQSPDGNFSDGPSPITVENVALLLAKAMGPDRAWSLLQECGLTLDLSERFTRTCDILRIAEKRQSHLGCFCLAILSNAAVNMRIQISLDPAFSSSGCIPRCGVAGSDEP", "length": 261, "header": "tr|A0AAA9SN64-1|E1B8R7_BOVIN Computationally mapped isoform of Hermansky-Pudlak syndrome 5 protein homolog OS=Bos taurus OX=9913 GN=HPS5 PE=3 SV=1 CANONICAL=E1B8R7-1" }, "locus": { "chromosome": "29", "start_pos": 26398038, "end_pos": 26385726, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090206.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090206.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085413.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085413.1" } ] } }, { "isoform_ac": "A0AAA9TYV5-1", "url": "https://www.uniprot.org/uniprotkb/E1B8R7/entry#A0AAA9TYV5-1", "sequence": { "sequence": "MTFVPVIPESYSHVLAEFESLDPLLSALRLDSTRLKCTSIAVSRKWLALGSSGGGLNLIQKEGWKHRLFLSHREGAISQIACCLHDDDYVAVATSQGLVVVWELNQERRGKPERIYVSSEHKGRKITALCWDTAILRIFVGDHLGKVSAIKLNTSKQAKAAAAFVMFPVQTITTVDSCVVQLDYLDGRLLVSSLTRSFLCDTEREKFWKIGNKERDGEYGACFFPGRCSAGQQPLIYCARPGSRMWEVNFDGEVLSTHQFKKLLSSPPLPVINLRSEPQYDHTIGSSQSLSFPKLLHISEHCVLTWTERGIYIFIPQNVQVLLWSEVKDIQDVAVCKNELFCLHLNGKVSHLSLLSVERCVERLLRRGLWNLAARTCCLFQNSVIASRGRKTLTVDKLEHLKSQLDLTTYGDLISQLEELILKLEPLDSACSSRRSSISSHESFSILDSGIYRIINSRRGSQSDEDSCSLHSQTLSEDERLKEFASHQEEDQPDHCCGSQGSEDNVSHASVTFETDKSETFLPFSIPLSFRSPSPLVSLQAVKESVSSFVRKTTEKIGTLHTSPDLKVRQEPRGDEQSCEEDVSPVTCPKEEDIEGKEEITSHPPEEDKFQELTMATAEAMSKLQDPLVLFEPKSLRMVLREWLSQLEKTFAVKDFSGISDTGSSSVESNQDMQLLDESRKGILDEEYEKEERDSLGNEETIDQTACESVNSLREPLDDDVFQICSPWSIADSLQKDLAELTTLCLELSVLNSEIKSASGHGDHTLQQCSLEMLTCQFLKKYFFLLDLKRAKESIKLSYPKSPCVWDTFIEGLKEMVSSSPTHIKMEEGDLPTRLKLLEDSVPFDSPLLIAYAARLYEKFGESALRSLIRFYPSILPSDVMQLCHHNPVQFLTYLDSLVKSRPEDQRPSFLESLLQPESLRLDWLLLAVSHDAPPSTSTMDDEGNPRPHSHLFSWGYSQLILHLIKLPADFTTKEKMTDICRSHGFWPGYLILCLELERRREAFTNIVYLNDMSLMEGDNGWIPETVEEWKLLLHLVQNTSTKPAPQQSPDGNFSDGPSPITVENVALLLAKAMGPDRAWSLLQECGLTLDLSERFTRTCDILRIAEKRQRALIQSMLEKCDRFLWSQQA", "length": 1130, "header": "tr|A0AAA9TYV5-1|E1B8R7_BOVIN Computationally mapped isoform of Hermansky-Pudlak syndrome 5 protein homolog OS=Bos taurus OX=9913 GN=HPS5 PE=3 SV=2 CANONICAL=E1B8R7-1" }, "locus": { "chromosome": "29", "start_pos": 26398091, "end_pos": 26363205, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111619.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111619.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103822.2", "url": "https://www.ensembl.org/id/ENSBTAP00000103822.2" } ] } }, { "isoform_ac": "A0AAA9TZG4-1", "url": "https://www.uniprot.org/uniprotkb/E1B8R7/entry#A0AAA9TZG4-1", "sequence": { "sequence": "MTFVPVIPESYSHVLAEFESLDPLLSALRLDSTRLKCTSIAVSRKWLALGSSGGGLNLIQKEGWKHRLFLSHREGAISQIACCLHDDDYVAVATSQGLVVVWELNQERRGKPERIYVSSEHKGRKITALCWDTAILRIFVGDHLGKVSAIKLNTSKQAKAAAAFVMFPVQTITTVDSCVVQLDYLDGRLLVSSLTRSFLCDTESEHCVLTWTERGIYIFIPQNVQVLLWSEVKDIQDVAVCKNELFCLHLNGKVSHLSLLSVERCVERLLRRGLWNLAARTCCLFQNSVIASRGRKTLTVDKLEHLKSQLDLTTYGDLISQLEELILKLEPLDSACSSRRSSISSHESFSILDSGIYRIINSRRGSQSDEDSCSLHSQTLSEDERLKEFASHQEEDQPDHCCGSQGSEDNVSHASVTFETDKSETFLPFSIPLSFRSPSPLVSLQAVKESVSSFVRKTTEKIGTLHTSPDLKVRQEPRGDEQSCEEDVSPVTCPKEEDIEGKEEITSHPPEEDKFQELTMATAEAMSKLQDPLVLFEPKSLRMVLREWLSQLEKTFAVKDFSGISDTGSSSVESNQDMQLLDESRKGILDEEYEKEERDSLGNEETIDQTACESVNSLREPLDDDVFQICSPWSIADSLQKDLAELTTLCLELSVLNSEIKSASGHGDHTLQQCSLEMLTCQFLKKYFFLLDLKRAKESIKLSYPKSPCVWDTFIEGLKEMVSSSPTHIKMEEGDLPTRLKLLEDSVPFDSPLLIAYAARLYEKFGESALRSLIRFYPSILPSDVMQLCHHNPVQFLTYLDSLVKSRPEDQRPSFLESLLQPESLRLDWLLLAVSHDAPPSTSTMDDEGNPRPHSHLFSWGYSQLILHLIKLPADFTTKEKMTDICRSHGFWPGYLILCLELERRREAFTNIVYLNDMSLMEGDNGWIPETVEEWKLLLHLVQNTSTKPAPQQSPDGNFSDGPSPITVENVALLLAKAMGPDRAWSLLQECGLTLDLSERFTRTCDILRIAEKRQRALIQSMLEKCDRFLWSQQA", "length": 1035, "header": "tr|A0AAA9TZG4-1|E1B8R7_BOVIN Computationally mapped isoform of Hermansky-Pudlak syndrome 5 protein homolog OS=Bos taurus OX=9913 GN=HPS5 PE=3 SV=1 CANONICAL=E1B8R7-1" }, "locus": { "chromosome": "29", "start_pos": 26398091, "end_pos": 26363205, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121924.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121924.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102962.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102962.1" } ] } }, { "isoform_ac": "E1B8R7-1", "url": "https://www.uniprot.org/uniprotkb/E1B8R7/entry#E1B8R7-1", "sequence": { "sequence": "MTFVPVIPESYSHVLAEFESLDPLLSALRLDSTRLKCTSIAVSRKWLALGSSGGGLNLIQKEGWKHRLFLSHREGAISQIACCLHDDDYVAVATSQGLVVVWELNQERRGKPERIYVSSEHKGRKITALCWDTAILRIFVGDHLGKVSAIKLNTSKQAKAAAAFVMFPVQTITTVDSCVVQLDYLDGRLLVSSLTRSFLCDTEREKFWKIGNKERDGEYGACFFPGRCSAGQQPLIYCARPGSRMWEVNFDGEVLSTHQFKKLLSSPPLPVINLRSEPQYDHTIGSSQSLSFPKLLHISEHCVLTWTERGIYIFIPQNVQVLLWSEVKDIQDVAVCKNELFCLHLNGKVSHLSLLSVERCVERLLRRGLWNLAARTCCLFQNSVIASRGRKTLTVDKLEHLKSQLDLTTYGDLISQLEELILKLEPLDSACSSRRSSISSHESFSILDSGIYRIINSRRGSQSDEDSCSLHSQTLSEDERLKEFASHQEEDQPDHCCGSQGSEGMKNYYSFGGHCLHFSMFKYSCGRTLEKRLIETLNFLYDYGDSGIPLSFRSPSPLVSLQAVKESVSSFVRKTTEKIGTLHTSPDLKVRQEPRGDEQSCEEDVSPVTCPKEEDIEGKEEITSHPPEEDKFQELTMATAEAMSKLQDPLVLFEPKSLRMVLREWLSQLEKTFAVKDFSGISDTGSSSVESNQDMQLLDESRKGILDEEYEKEERDSLGNEETIDQTACESVNSLREPLDDDVFQICSPWSIADSLQKDLAELTTLCLELSVLNSEIKSASGHGDHTLQQCSLEMLTCQFLKKYFFLLDLKRAKESIKLSYPKSPCVWDTFIEGLKEMVSSSPTHIKMEEGDLPTRLKLLEDSVPFDSPLLIAYAARLYEKFGESALRSLIRFYPSILPSDVMQLCHHNPVQFLTYLDSLVKSRPEDQRPSFLESLLQPESLRLDWLLLAVSHDAPPSTSTMDDEGNPRPHSHLFSWGYSQLILHLIKLPADFTTKEKMTDICRSHGFWPGYLILCLELERRREAFTNIVYLNDMSLMEGDNGWIPETVEEWKLLLHLVQNTSTKPAPQQSPDGNFSDGPSPITVENVALLLAKAMGPDRAWSLLQECGLTLDLSERFTRTCDILRIAEKRQRALIQSMLEKCDRFLWSQQA", "length": 1152, "header": "tr|E1B8R7-1|E1B8R7_BOVIN Isoform 1 of Hermansky-Pudlak syndrome 5 protein homolog OS=Bos taurus OX=9913 GN=HPS5 PE=3 SV=3 CANONICAL=E1B8R7-1" }, "locus": { "chromosome": "29", "start_pos": 26398091, "end_pos": 26363205, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006797.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006797.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006797.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006797.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510165", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510165", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B8R7", "url": "https://www.uniprot.org/uniprotkb/E1B8R7" } ], "pmid": "" }, { "name": "BLOC-2 complex", "id": "GO:0031084", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031084", "evidence": [ { "database": "UniProtKB", "id": "E1B8R7", "url": "https://www.uniprot.org/uniprotkb/E1B8R7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1061, "end_pos": 1063, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1075, "end_pos": 1077, "annotation": "n_glycosylation_sequon" }, { "start_pos": 153, "end_pos": 155, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8R7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1152, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8R7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8R7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R7" }, { "id": "PF23758", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23758" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HPS5 TPR", "eco_id": "ECO_0000259", "start_pos": 744, "end_pos": 1123, "start_aa": "Phe", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B8R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R7" }, { "id": "PF23756", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23756" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HPS5-like beta-propeller", "eco_id": "ECO_0000259", "start_pos": 15, "end_pos": 345, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1061, "end_pos": 1063 }, { "start_pos": 1075, "end_pos": 1077 }, { "start_pos": 153, "end_pos": 155 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B8C7-1", "uniprot_ac": "E1B8C7", "uniprot_id": "E1B8C7_BOVIN", "mass": { "chemical_mass": 89723.0, "monoisotopic_mass": 89723.0 }, "refseq": {}, "gene_names": [ { "name": "MDM1", "type": "recommended", "evidence": [ { "id": "E1B8C7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8C7" } ] } ], "protein_names": [ { "name": "Nuclear protein MDM1", "type": "recommended", "evidence": [ { "id": "E1B8C7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8C7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules.", "evidence": [ { "database": "UniProtKB", "id": "E1B8C7", "url": "https://www.uniprot.org/uniprotkb/E1B8C7#function" }, { "database": "UniProtKB", "id": "ARBA00045771", "url": "https://www.uniprot.org/uniprotkb/ARBA00045771#function" }, { "database": "UniProtKB", "id": "A0A3Q1MRF5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRF5#function" }, { "database": "UniProtKB", "id": "A0AAA9U197", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U197#function" }, { "database": "UniProtKB", "id": "A0AAA9SIZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIZ2#function" }, { "database": "UniProtKB", "id": "A0AAA9SVC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC4#function" }, { "database": "UniProtKB", "id": "A0AAA9T644", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T644#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8C7", "url": "https://www.uniprot.org/uniprotkb/E1B8C7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MDM1", "url": "https://www.uniprot.org/uniprotkb/E1B8C7", "locus": { "chromosome": "5", "start_pos": 45475517, "end_pos": 45446495, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019738", "url": "https://www.ensembl.org/id/ENSBTAG00000019738" } ] } } ], "crossref": [ { "id": "E1B8C7", "url": "https://alphafold.ebi.ac.uk/entry/E1B8C7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019738", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019738", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR029136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR32078", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32078", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32078:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32078:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15501", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15501", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MRF5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRF5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRF5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVC4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVC4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T644", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T644", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T644-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T644-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U197", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U197", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U197-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U197-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8C7", "url": "https://www.uniprot.org/uniprotkb/E1B8C7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8C7-1", "url": "https://www.uniprot.org/uniprotkb/E1B8C7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGFSSLNWFLVFRMGGERQSVWAQGGNRGVRRRVVEDAGPKLLLGNVLLSPRPSELFVPLTVGVAGAPAQADMPVRFKGLSEYQRNFLWKKSYLSESCNSSMGRRHPWAGLRSDQLGITREPSFISKRRVPHHDPQISKSLEWNAATSENDVVLSPETEAPRTPESQEAEQTDVNQERLLAVEASRGPKRTRSHSADSRSEGASDIVENKEDIKANDVPANENVELKHSTKPLSENVDDRLNRLLQKKAGLTVVPSHNVLRNSEYQRQFVWKTPKQPAPAFAANQVFHNKSKFIPQFKGNSFIHETEYKRNFKGLSPVKEPKLRSHLKENGNFETISPEKKCNKADDPLKSEAEMESKNSNQPKKKLTPWRHQRLGKVNSEYRAKFLSPAQYLYKAGAWTRVKENIPNQASLNAMWYAEVKELREKAEFYRKRVQGTHFSRDHLNQILSENNRCWDVSSTTSSEGTISSNIRALDLAGDPTSHKTSQKCPSTQLEEKRTILEEQPQKTTTEKLGVSNAPIPVRRRLAWDAEDTTEDVQKQPSGEEEKGEEEKEEGDKQVNVEELEKLEVQEKSKADKIKEESESSSMSSGKGGRLPTPKLRELGGIQRTHHDLTTPAVGGAVLVSPSKVKPPVIEQRKRISSQDGLETLKNDFRKKESRAISLLTSPAAGIKTVDPLPLREDSEPNIPKFVETTLPVSKMPEYPPNTPGKSASPPCATSYWHPSRRIQGSLRDPEFQHNVGKSRMNNFQLHQHEAFNDEDEDRLSEISARSAASSLQALQTLARAQKRKENFWGKT", "length": 796, "header": "tr|E1B8C7-1|E1B8C7_BOVIN Isoform 1 of Nuclear protein MDM1 OS=Bos taurus OX=9913 GN=MDM1 PE=3 SV=4 CANONICAL=E1B8C7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MRF5-1", "url": "https://www.uniprot.org/uniprotkb/E1B8C7/entry#A0A3Q1MRF5-1", "sequence": { "sequence": "MGFSSLNWFLVFRMGGERQSVWAQGGNRGVRRRVVEDAGPKLLLGNVLLSPRPSELFVPLTVGVAGAPAQADMPVRFKGLSEYQRNFLWKKSYLSESCNSSMGRRHPWAGLRSDQLGITREPSFISKRRVPHHDPQISKSLEWNAATSENDVVLSPETEAPRTPESQEAEQTDVNQERLLAVEASRGPKRTRSHSADSRSEGASDIVENKEDIKANDVPANENVELKHSTKPLSENVDDRLNRLLQKKAGLTVVPSHNVLRNSEYQRQFVWKTPKQPAPAFAANQVFHNKSKFIPQFKGNSFIHETEYKRNFKGLSPVKEPKLRSHLKENGNFETISPEKKCNKADDPLKSEAEMESKNSNQPKKKLTPWRHQRLGKVNSEYRAKFLSPAQYLYKAGAWTRVKENIPNQVKELREKAEFYRKRVQGTHFSRDHLNQILSENNRCWDVSSTTSSEGTISSNIRALDLAGDPTSHKTSQKCPSTQLEEKRTILEEQPQKTTTEKLGVSNAPIPVRRRLAWDAEDTTEDVQKQPSGEEEKGEEEKEEGDKQVNVEELEKLEVQEKSKADKIKEESESSSMSSGKGGRLPTPKLRELGGIQRTHHDLTTPAVGGAVLVSPSKVKPPVIEQRKRISSQDGLETLKNDFRKKESRAISLLTSPAAGIKTVDPLPLREDSEPNIPKFVETTLPVSKMPEYPPNTPGKSASPPCATSYWHPSRRIQGSLRDPEFQHNVGKSRMNNFQLHQHEAFNDEDEDRLSEISARSAASSLQALQTLARAQKRKENFWGKT", "length": 786, "header": "tr|A0A3Q1MRF5-1|E1B8C7_BOVIN Computationally mapped isoform of Nuclear protein MDM1 OS=Bos taurus OX=9913 GN=MDM1 PE=3 SV=2 CANONICAL=E1B8C7-1" }, "locus": { "chromosome": "5", "start_pos": 45474786, "end_pos": 45446606, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073818.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073818.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074352.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074352.2" } ] } }, { "isoform_ac": "A0AAA9SIZ2-1", "url": "https://www.uniprot.org/uniprotkb/E1B8C7/entry#A0AAA9SIZ2-1", "sequence": { "sequence": "MPVRFKGLSEYQRNFLWKKSYLSESCNSSMGRRHPWAGLRSDQLGTQGRYRAKIQHNDISSLLILVCTA", "length": 69, "header": "tr|A0AAA9SIZ2-1|E1B8C7_BOVIN Computationally mapped isoform of Nuclear protein MDM1 OS=Bos taurus OX=9913 GN=MDM1 PE=3 SV=1 CANONICAL=E1B8C7-1" }, "locus": { "chromosome": "5", "start_pos": 45450555, "end_pos": 45446822, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088570.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088570.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085305.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085305.1" } ] } }, { "isoform_ac": "A0AAA9SVC4-1", "url": "https://www.uniprot.org/uniprotkb/E1B8C7/entry#A0AAA9SVC4-1", "sequence": { "sequence": "MPVRFKGLSEYQRNFLWKKSYLSESCNSSMGRRHPWAGLRSDQLGITREPSFISKRRVPHHDPQISKSLEWNAATSENDVVLSPETEAPRTPESQEAEQTDVNQERLLAVEASRGPKRTRSHSADSRSEGASDIVENKEDIKANDVPANENVELKHSTKPLSENVDDRLNRLLQKKAGLTVVPSHNVLRNSEYQRQFVWKTPKQPAPAFAANQCNKADDPLKSEAEMESKNSNQPKKKLTPWRHQRLGKVNSEYRAKFLSPAQYLYKAGAWTRVKENIPNQVKELREKAEFYRKRVQGTHFSRDHLNQILSENNRCWDVSSTTSSEGTISSNIRALDLAGDPTSHKTSQKCPSTQLEEKRTILEEQPQKTTTEKLGVSNAPIPVRRRLAWDAEDTTEDVQKQPSGEEEKGEEEKEEGDKQVNVEELEKLEVQEKSKADKIKEESESSSMSSGKGGRLPTPKLRELGGIQRTHHDLTTPAVGGAVLVSPSKVKPPVIEQRKRISSQDGLETLKNDFRKKESRAISLLTSPAAGIKTVDPLPLREDSEPNIPKFVETTLPVSKMPEYPPNTPGKSASPPCATSYWHPSRRIQGSLRDPEFQHNVGKSRMNNFQLHQHEAFNDEDEDRLSEISARSAASSLQALQTLARAQKRKENFWGKT", "length": 658, "header": "tr|A0AAA9SVC4-1|E1B8C7_BOVIN Computationally mapped isoform of Nuclear protein MDM1 OS=Bos taurus OX=9913 GN=MDM1 PE=3 SV=1 CANONICAL=E1B8C7-1" }, "locus": { "chromosome": "5", "start_pos": 45474786, "end_pos": 45446822, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132335.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132335.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087139.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087139.1" } ] } }, { "isoform_ac": "A0AAA9T644-1", "url": "https://www.uniprot.org/uniprotkb/E1B8C7/entry#A0AAA9T644-1", "sequence": { "sequence": "MPVRFKGLSEYQRNFLWKKSYLSESCNSSMGRRHPWAGLRSDQLGITREPSFISKRRVPHHDPQISKSLEWNAATSENDVVLSPETEAPRTPESQEAEQTDVNQERLLAVEASRGPKRTRSHSADSRSEGASDIVENKEDIKANDVPANENVELKHSTKPLSENVDDRVFHNKSKFIPQFKGNSFIHETEYKRNFKGLSPVKEPKLRSHLKENGNFETISPEKKCNKADDPLKSEAEMESKNSNQPKKKLTPWRHQRLGKVNSEYRAKFLSPAQYLYKAGAWTRVKENIPNQASLNAMWYAEVKELREKAEFYRKRVQGTHFSRDHLNQILSENNRCWDVSSTTSSEGTISSNIRALDLAGDPTSHKTSQKCPSTQLEEKRTILEEQPQKTTTEKLGVSNAPIPVRRRLAWDAEDTTEDVQKQPSGEEEKGEEEKEEGDKQVNVEELEKLEVQEKSKADKIKEESESSSMSSGKGGRLPTPKLRELGGIQRTHHDLTTPAVGGAVLVSPSKVKPPVIEQRKRISSQDGLETLKNDFRKKESRAISLLTSPAAGIKTVDPLPLREDSEPNIPKFVETTLPVSKMPEYPPNTPGKSASPPCATSYWHPSRRIQGSLRDPEFQHNVGKSRMNNFQLHQHEAFNDEDEDRLSEISARSAASSLQALQTLARAQKRKENFWGKT", "length": 679, "header": "tr|A0AAA9T644-1|E1B8C7_BOVIN Computationally mapped isoform of Nuclear protein MDM1 OS=Bos taurus OX=9913 GN=MDM1 PE=3 SV=2 CANONICAL=E1B8C7-1" }, "locus": { "chromosome": "5", "start_pos": 45474786, "end_pos": 45446822, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129668.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129668.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092228.2", "url": "https://www.ensembl.org/id/ENSBTAP00000092228.2" } ] } }, { "isoform_ac": "A0AAA9U197-1", "url": "https://www.uniprot.org/uniprotkb/E1B8C7/entry#A0AAA9U197-1", "sequence": { "sequence": "MPVRFKGLSEYQRNFLWKKSYLSESCNSSMGRRHPWAGLRSDQLGITREPSFISKRRVPHHDPQISKSLEWNAATSENDVVLSPETEAPRTPESQEAEQTDVNQERLLAVEASRGPKRTRSHSADSRSEGASDIVENKEDIKANDVPANENVELKHSTKPLSENVDDRVCVFTVFLFRSIEFSINFIIISVILHFVLNFFLLFPCSKSRIDYKVMLTLVIMN", "length": 222, "header": "tr|A0AAA9U197-1|E1B8C7_BOVIN Computationally mapped isoform of Nuclear protein MDM1 OS=Bos taurus OX=9913 GN=MDM1 PE=3 SV=2 CANONICAL=E1B8C7-1" }, "locus": { "chromosome": "5", "start_pos": 45451483, "end_pos": 45446822, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090336.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090336.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103536.2", "url": "https://www.ensembl.org/id/ENSBTAP00000103536.2" } ] } }, { "isoform_ac": "E1B8C7-1", "url": "https://www.uniprot.org/uniprotkb/E1B8C7/entry#E1B8C7-1", "sequence": { "sequence": "MGFSSLNWFLVFRMGGERQSVWAQGGNRGVRRRVVEDAGPKLLLGNVLLSPRPSELFVPLTVGVAGAPAQADMPVRFKGLSEYQRNFLWKKSYLSESCNSSMGRRHPWAGLRSDQLGITREPSFISKRRVPHHDPQISKSLEWNAATSENDVVLSPETEAPRTPESQEAEQTDVNQERLLAVEASRGPKRTRSHSADSRSEGASDIVENKEDIKANDVPANENVELKHSTKPLSENVDDRLNRLLQKKAGLTVVPSHNVLRNSEYQRQFVWKTPKQPAPAFAANQVFHNKSKFIPQFKGNSFIHETEYKRNFKGLSPVKEPKLRSHLKENGNFETISPEKKCNKADDPLKSEAEMESKNSNQPKKKLTPWRHQRLGKVNSEYRAKFLSPAQYLYKAGAWTRVKENIPNQASLNAMWYAEVKELREKAEFYRKRVQGTHFSRDHLNQILSENNRCWDVSSTTSSEGTISSNIRALDLAGDPTSHKTSQKCPSTQLEEKRTILEEQPQKTTTEKLGVSNAPIPVRRRLAWDAEDTTEDVQKQPSGEEEKGEEEKEEGDKQVNVEELEKLEVQEKSKADKIKEESESSSMSSGKGGRLPTPKLRELGGIQRTHHDLTTPAVGGAVLVSPSKVKPPVIEQRKRISSQDGLETLKNDFRKKESRAISLLTSPAAGIKTVDPLPLREDSEPNIPKFVETTLPVSKMPEYPPNTPGKSASPPCATSYWHPSRRIQGSLRDPEFQHNVGKSRMNNFQLHQHEAFNDEDEDRLSEISARSAASSLQALQTLARAQKRKENFWGKT", "length": 796, "header": "tr|E1B8C7-1|E1B8C7_BOVIN Isoform 1 of Nuclear protein MDM1 OS=Bos taurus OX=9913 GN=MDM1 PE=3 SV=4 CANONICAL=E1B8C7-1" }, "locus": { "chromosome": "5", "start_pos": 45474786, "end_pos": 45446606, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026305.8", "url": "https://www.ensembl.org/id/ENSBTAT00000026305.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026305.7", "url": "https://www.ensembl.org/id/ENSBTAP00000026305.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B8C7", "url": "https://www.uniprot.org/uniprotkb/E1B8C7" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "E1B8C7", "url": "https://www.uniprot.org/uniprotkb/E1B8C7" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "E1B8C7", "url": "https://www.uniprot.org/uniprotkb/E1B8C7" } ], "pmid": "" }, { "name": "centriolar satellite", "id": "GO:0034451", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034451", "evidence": [ { "database": "UniProtKB", "id": "E1B8C7", "url": "https://www.uniprot.org/uniprotkb/E1B8C7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "E1B8C7", "url": "https://www.uniprot.org/uniprotkb/E1B8C7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of centriole replication", "id": "GO:0046600", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046600", "evidence": [ { "database": "UniProtKB", "id": "E1B8C7", "url": "https://www.uniprot.org/uniprotkb/E1B8C7" } ], "pmid": "" }, { "name": "retina development in camera-type eye", "id": "GO:0060041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060041", "evidence": [ { "database": "UniProtKB", "id": "E1B8C7", "url": "https://www.uniprot.org/uniprotkb/E1B8C7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 289, "end_pos": 291, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8C7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 796, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8C7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8C7" } ], "lectin_list": [], 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"InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10877", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10877", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10877:SF185", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10877:SF185", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01477", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01477", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08016", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08016", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20519", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20519", "database": "Pfam", "categories": [ "Protein 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{ "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "E1BC61", "url": "https://www.uniprot.org/uniprotkb/E1BC61" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BC61", "url": "https://www.uniprot.org/uniprotkb/E1BC61" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of mechanical stimulus", "id": "GO:0050982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050982", "evidence": [ { "database": "UniProtKB", "id": "E1BC61", "url": "https://www.uniprot.org/uniprotkb/E1BC61" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1026, "end_pos": 1028, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1344, "end_pos": 1346, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1347, "end_pos": 1349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1443, "end_pos": 1445, "annotation": "n_glycosylation_sequon" }, { "start_pos": 147, "end_pos": 149, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1633, "end_pos": 1635, "annotation": "n_glycosylation_sequon" }, { "start_pos": 163, "end_pos": 165, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1690, "end_pos": 1692, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1741, "end_pos": 1743, "annotation": "n_glycosylation_sequon" }, { "start_pos": 186, "end_pos": 188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1917, "end_pos": 1919, "annotation": "n_glycosylation_sequon" }, { "start_pos": 200, "end_pos": 202, "annotation": "n_glycosylation_sequon" }, { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" }, { 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"database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095561" } ] } ], "function": [ { "annotation": "Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MPW4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPW4#function" }, { "database": "UniProtKB", "id": "ARBA00024863", "url": "https://www.uniprot.org/uniprotkb/ARBA00024863#function" }, { "database": "UniProtKB", "id": "A0AAA9RV02", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV02#function" }, { "database": "UniProtKB", "id": "A6QR40", "url": "https://www.uniprot.org/uniprotkb/A6QR40#function" }, { "database": "UniProtKB", "id": "A0AAF6YI23", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI23#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A6QR40", "url": "https://www.uniprot.org/uniprotkb/A6QR40" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ELMO3", "url": "https://www.uniprot.org/uniprotkb/A6QR40", "locus": { "chromosome": "18", "start_pos": 34840253, "end_pos": 34834852, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001286", "url": "https://www.ensembl.org/id/ENSBTAG00000001286" } ] } } ], "crossref": [ { "id": "A6QR40", "url": "https://alphafold.ebi.ac.uk/entry/A6QR40", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001286", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001286", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13359", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13359", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525427", "url": "https://www.ncbi.nlm.nih.gov/gene/525427", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006816", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006816", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024574", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024574", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050868", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050868", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525427", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525427", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KIAIQMM", "url": "https://omabrowser.org/oma/group/KIAIQMM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MPW4", "url": "https://www.orthodb.org/?gene=A0A3Q1MPW4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A6QR40", "url": "https://www.orthodb.org/?gene=A6QR40", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12771", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12771", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12771:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12771:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04727", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04727", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11841", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11841", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16457", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16457", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26964", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26964", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095561", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPW4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPW4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPW4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RV02", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RV02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YI23", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YI23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YI23-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QR40", "url": "https://www.uniprot.org/uniprotkb/A6QR40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6QR40-1", "url": "https://www.uniprot.org/uniprotkb/A6QR40-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPPRNVVKIAVQMRDAIPQLIQLDQAKPLAAVLKEVCDAWSLPHSERYALQFADGHRRYITENNRMEIKNGSILCLSTAPDREAERLLRGLQSESREGRREALRHLLLLAPDLTFAREVISRDGLQRLGTIIEDGDDLGEVLALALRAFLELMEHGVVSWETLSIPFVRKVVCYVNMNLMDASVQPLALGLLENVTLSSPTLGQLVKSEVPLDRLLVHLQVMNQQLQTKAMALLTALLQGATPAERKHMLDYLWQRNLRQFIYKNIIHSAAPLGDEMAHHLYVLQALMLGLLEPRMRTPLDPYSQEQREQLQALRQAAFEPEGESVGAGLSADRRRSLCAREFRKLGFSNSNPAQDLERVPPGLLALDNMLYFSRQAPSAYSRFVLENSSREDKHECPFARSSIQLTVLLCDLLHVGEPCSETAQDFSPMFFGQDQSFHELFCVSIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPSSLELFRTKVNALTYGEVLRLRQTERLHQEGTLAPPILELREKLKPELMGLIRQQRLLRLCEGTLFHKISSRRRQDKLWFCCLSPNHKVLQYGDVEEGVGPPTPESLPEQLPVADIRALLTGKDCPHVREKGSGKQNKDVCELAFSVSYDHGEEEAYLNFIAPSKREMG", "length": 652, "header": "sp|A6QR40-1|ELMO3_BOVIN Isoform 1 of Engulfment and cell motility protein 3 OS=Bos taurus OX=9913 GN=ELMO3 PE=2 SV=1 CANONICAL=A6QR40-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MPW4-1", "url": "https://www.uniprot.org/uniprotkb/A6QR40/entry#A0A3Q1MPW4-1", "sequence": { "sequence": "MAPPRNVVKIAVQMRDAIPQLIQLDQAKPLAAVLKEVCDAWSLPHSERYALQFADGHRRYITENNRMEIKNGSILCLSTAPDREAERLLRGLQSESREGRREALRHLLLLAPDLTFAREVISRDGLQRLGTIIEDGDDLGEVLALALRAFLELMEHGVVSWETLSIPFVRKVVCYVNMNLMDASVQPLALGLLENVTLSSPTLGQLVKSEVPLDRLLVHLQVMNQQLQTKAMALLTALLQGATPAERKHMLDYLWQRNLRQFIYKNIIHSAAPLGDEMAHHLYVLQALMLGLLEPRMRTPLDPYSQEQREQLQALRQAAFEPEGESVGAGLSADRRRSLCAREFRKLGFSNSNPAQDLERVPPGLLALDNMLYFSRQAPSAYSRFVLENSSREDKHECPFARSSIQLTVLLCDLLHVGEPCSETAQDFSPMFFGQDQSFHELFCVSIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPSSLELFRTKVNALTYGEVLRLRQTERLHQEGTLAPPILELREKLKPELMGLIRQQRLLRLCEGTLFHKISSRRRQDMCCPEPPHPGAARGLSGQPSLFPAVPVADIRALLTGKDCPHVREKGSGKQNKDVCELAFSVSYDHGEEEAYLNFIAPSKREVSIWAG", "length": 646, "header": "tr|A0A3Q1MPW4-1|ELMO3_BOVIN Computationally mapped isoform of Engulfment and cell motility protein 3 OS=Bos taurus OX=9913 GN=ELMO3 PE=2 SV=1 CANONICAL=A6QR40-1" }, "locus": { "chromosome": "18", "start_pos": 34838964, "end_pos": 34835010, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073417.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073417.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073570.1", "url": "https://www.ensembl.org/id/ENSBTAP00000073570.1" } ] } }, { "isoform_ac": "A0AAA9RV02-1", "url": "https://www.uniprot.org/uniprotkb/A6QR40/entry#A0AAA9RV02-1", "sequence": { "sequence": "MAPPRNVVKIAVQMRDAIPQLIQLDQAKPLAAVLKEVCDAWSLPHSERYALQFADGHRRYITENDREAERLLRGLQSESREGRREALRHLLLLAPDLTFAREVISRDGLQRLGTIIEDGDDLGEVLALALRAFLELMEHGVVSWETLSIPFVRKVVCYVNMNLMDASVQPLALGLLENVTLSSPTLGQLVKSEVPLDRLLVHLQVMNQQLQTKAMALLTALLQGATPAERKHMLDYLWQRNLRQFIYKNIIHSAAPLGDEMAHHLYVLQALMLGLLEPRMRTPLDPYSQEQREQLQALRQAAFEPEGESVGAGLSADRRRSLCAREFRKLGFSNSNPAQDLERVPPGLLALDNMLYFSRQAPSAYSRFVLENSSREDKHECPFARSSIQLTVLLCDLLHVGEPCSETAQDFSPMFFGQDQSFHELFCVSIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPSSLELFRTKVNALTYGEVLRLRQTERLHQEGTLAPPILELREKLKPELMGLIRQQRLLRLCEGTLFHKISSRRRQDKLWFCCLSPNHKVLQYGDVEEGVGPPTPESLPEQLPVADIRALLTGKDCPHVREKGSGKQNKDVCELAFSVSYDHGEEEAYLNFIAPSKREFHLWTDGLSALLGNPMGSEQTRLDLEQLLTMETKLRLLELENVPIPEQPPPVPPPPTNFNFCYDCSIAEP", "length": 703, "header": "tr|A0AAA9RV02-1|ELMO3_BOVIN Computationally mapped isoform of Engulfment and cell motility protein 3 OS=Bos taurus OX=9913 GN=ELMO3 PE=2 SV=1 CANONICAL=A6QR40-1" }, "locus": { "chromosome": "18", "start_pos": 34839249, "end_pos": 34835010, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122516.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122516.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077097.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077097.1" } ] } }, { "isoform_ac": "A0AAF6YI23-1", "url": "https://www.uniprot.org/uniprotkb/A6QR40/entry#A0AAF6YI23-1", "sequence": { "sequence": "MAPPRNVVKIAVQMRDAIPQLIQLDQAKPLAAVLKEVCDAWSLPHSERYALQFADGHRRYITENNRMEIKNGSILCLSTAPDREAERLLRGLQSESREGRREALRHLLLLAPDLTFAREVISRDGLQRLGTIIEDGDDLGEVLALALRAFLELMEHGVVSWETLSIPFVRKVVCYVNMNLMDASVQPLALGLLENVTLSSPTLGQLVKSEVPLDRLLVHLQVMNQQLQTKAMALLTALLQGATPAERKHMLDYLWQRNLRQFIYKNIIHSAAPLGDEMAHHLYVLQALMLGLLEPRMRTPLDPYSQEQREQLQALRQAAFEPEGESVGAGLSADRRRSLCAREFRKLGFSNSNPAQDLERVPPGLLALDNMLYFSRQAPSAYSRFVLENSSREDKHECPFARSSIQLTVLLCDLLHVGEPCSETAQDFSPMFFGQDQSFHELFCVSIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPSSLELFRTKVNALTYGEVLRLRQTERLHQEGTLAPPILELREKLKPELMGLIRQQRLLRLCEGTLFHKISSRRRQDKLWFCCLSPNHKVLQYGDVEEGVGPPTPESLPEQLPVADIRALLTGKDCPHVREKGSGKQNKDVCELAFSVSYDHGEEEAYLNFIAPSKRELAPSPVPPVDRWAERPAGQSHGQ", "length": 673, "header": "tr|A0AAF6YI23-1|ELMO3_BOVIN Computationally mapped isoform of Engulfment and cell motility protein 3 OS=Bos taurus OX=9913 GN=ELMO3 PE=2 SV=2 CANONICAL=A6QR40-1" }, "locus": { "chromosome": "18", "start_pos": 34839092, "end_pos": 34835010, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001696.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001696.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001696.6", "url": "https://www.ensembl.org/id/ENSBTAP00000001696.6" } ] } }, { "isoform_ac": "A6QR40-1", "url": "https://www.uniprot.org/uniprotkb/A6QR40/entry#A6QR40-1", "sequence": { "sequence": "MAPPRNVVKIAVQMRDAIPQLIQLDQAKPLAAVLKEVCDAWSLPHSERYALQFADGHRRYITENNRMEIKNGSILCLSTAPDREAERLLRGLQSESREGRREALRHLLLLAPDLTFAREVISRDGLQRLGTIIEDGDDLGEVLALALRAFLELMEHGVVSWETLSIPFVRKVVCYVNMNLMDASVQPLALGLLENVTLSSPTLGQLVKSEVPLDRLLVHLQVMNQQLQTKAMALLTALLQGATPAERKHMLDYLWQRNLRQFIYKNIIHSAAPLGDEMAHHLYVLQALMLGLLEPRMRTPLDPYSQEQREQLQALRQAAFEPEGESVGAGLSADRRRSLCAREFRKLGFSNSNPAQDLERVPPGLLALDNMLYFSRQAPSAYSRFVLENSSREDKHECPFARSSIQLTVLLCDLLHVGEPCSETAQDFSPMFFGQDQSFHELFCVSIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPSSLELFRTKVNALTYGEVLRLRQTERLHQEGTLAPPILELREKLKPELMGLIRQQRLLRLCEGTLFHKISSRRRQDKLWFCCLSPNHKVLQYGDVEEGVGPPTPESLPEQLPVADIRALLTGKDCPHVREKGSGKQNKDVCELAFSVSYDHGEEEAYLNFIAPSKREMG", "length": 652, "header": "sp|A6QR40-1|ELMO3_BOVIN Isoform 1 of Engulfment and cell motility protein 3 OS=Bos taurus OX=9913 GN=ELMO3 PE=2 SV=1 CANONICAL=A6QR40-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 586, "start_aa": "Thr", "end_pos": 586, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr586", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:525427", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525427", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M6Z4G1-1", "protein_name": "Engulfment and cell motility protein 3 isoform X1", "gene_name": "elmo3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPQQKDIVKIAIQMPGAYPQLIQLDQKKPLTSVIKEVCDKWNLPGPENYALQYADGIQTYITESNRLDIKNGSILRLTKAPGRCAEDLYKGIQSSDSNVRCDSLNLLAIVSTDITFAQEFISRDGHSLLVKIVEDAQESPVIMTHTLTAFMELMDHGIVSWENLSSVFIKKMASFVNAKVLDTSIQQVSLAILESMVLSSSSLFTEVKQEITLERLLSHLQVYVDYTIHTRTNQQLQTKAMALLMALLQAGGEADRQELFEFLEKRNLRQYIHKNIIHSSSSVGDEMAHYLYVLQTVRLNHLEPRMKTPLDSYSQEQREMLHGLRQAAFETESESGLSNERRRSLCAKEFKKLGFSNNSNPGQDLSRCPPGLLALDTMAYFASRYPDAYSRFVLENSSREDKHECPFARSSIQLTLILCEILRIGEPPSETGSDYHPIFFAQDRLLEELFCICIQLLNKTWKEMRATQEDFDKVMQVVREQITRTLASKPTSLELFKNKVNALNYSEILKLRQTERLHQEETLAPPVLELKERLKPELLELIRQQRLNRLCHGTLFRKMSSRRRQDKLWYCRLSPNHKVLHYGDVEEETEMPSIEALQDKIPVADIKNVVTGKDCPHMKENKGKQTKEVLDLAFSITYDVEEYSLNFIASSRTDFCLWTDGLSVLLGKEMSSESMRSELEILLSMEIKLRLLDLENVPIPDAAPPIPKPPSNFNFCYDFSQTEQ", "length": 724 }, "evidence": [ { "id": "A6QR40", "url": "https://omabrowser.org/oma/group/A6QR40/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q499U2-1", "protein_name": "Engulfment and cell motility protein 3", "gene_name": "Elmo3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAPPRNVVKIAVQMSDAIPQLIQLDQAKPLATVLKEVCDTWSLTHPEHYALQFADGHRKYITENNRSEIKNGSILCLSTAPDLKAQQLLSRLQNASREGCCEVLRNLVPLASDMTFAQEVISRDGLQKLSTIIENGDDLGEMLALGLRAFLELMEHGVVSWETLSISFVRKVVSYVNMNLMDASVQPLALRLLESVTLSSPTLGQLVKSEVPLDRLLVHLQVMNQQLQTKAMALLTALLQGASPAERKDMLDCLWKKNLRQFIYKNIIHSAAPMGDEMAHHLYVLQALTLGLLEPRMRTPLDPYSQEQREQLQALRQAAFEPDGESLGTGLSADRRRSLCVREFRKLGFSNSSPAQDLERVPPGLLALDNMLYFSRHAPSAYSRFVLENSSREDKHECPFARSSIQLTVLLCELLHVGEPCSETAQDFSPMFFSQDHSFHELFCVAIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPTSLELFRTKVNALTYGEVLRLRQTERLHQEGTLAPPILELREKLKPELMGLIRQQRLLRLCEGMLFRKISSRRRQDKLWFCCLSPNHKVLQYGDVEEGANPPTLESLTEQLPVADIRALLMGKDCPHVREKGSGKQNKDLYELAFSISYDHGEEEAYLNFIAPSKRDFYLWTDGLSALLGSTMGSEQTRLDLEQLLTMETKLRLLELENVPIPEHPPPVPPPPTNFNFCYDYSMTEP", "length": 720 }, "evidence": [ { "id": "A6QR40", "url": "https://omabrowser.org/oma/group/A6QR40/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BYZ7-1", "protein_name": "Engulfment and cell motility protein 3", "gene_name": "Elmo3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPPRNVVKIAVQMSDAIPQLIQLDQAKPLATVLKEVCDAWSLTHPEHYALQFADGHRKYITENNRLEIKNGSILCLSTAPDLKAQQLLGRLQNTSREGCCEVLRNLVLLASDMTFAQEVISRDGLQKLSTIIENGDDLGEMLALGLRAFLELMEHGVVSWETLSISFVRKVISYVNMNLMDASVQPLALRLLESVTLSSPALGQLVKSEVPLDRLLVHLQVMNHQLQTKAMALLTALLQGASPTERKEMLDHLWKKNLRQFIYKNIIHSATPMGDEMAHHLYVLQALTLGLLEPRMRTPLDPYSQEQRDQLQALRQAAFEPEGESLGTGLSADRRRSLCVREFRKLGFSNSNPAQDLERVPPGLLALDNMLYFSRHAPSAYSRFVLENSSREDKHECPFARSSIQLTALLCELLRVGEPCSETAQDFSPMFFSQDHSFHELFCVAIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPTSLELFRTKVNALTYGEVLRLRQTERLHQEGTLAPPILELREKLKPELMGLIRQQRLLRLCEGMLFRKISSRRRQDKLWFCCLSPNHKVLQYGDVEEGAKPPTLESLPEQLPVADIRALLMGKDCPHVREKGSGKQNKDLYELAFSISYDHGEEEAYLNFIAPSKRDFYLWTDGLSALLGSTMGSELTRLDLEQLLTMETKLRLLELENVPIPEQPPPVPPPPTNFNFCYDYSITEP", "length": 720 }, "evidence": [ { "id": "A6QR40", "url": "https://omabrowser.org/oma/group/A6QR40/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96BJ8-1", "protein_name": "Engulfment and cell motility protein 3", "gene_name": "ELMO3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPPRNVVKIAIKMRDAIPQLIQLDQAKPLAAVLKEVCDAWSLTHSERYALQFADGHRRYITENNRAEIKNGSILCLSTAPDLEAEQLLGGLQSNSPEGRREALRRLVPLASDMIFAREVISRNGLQILGTIIEDGDDLGEVLALSLRAFSELMEHGVVSWETLSIPFVRKVVCYVNMNLMDASVPPLALGLLESVTLSSPALGQLVKSEVPLDRLLVHLQVMNQQLQTKAMALLTALLQGASPVERKHMLDYLWQRNLRQFIYKNIIHSAAPMGDEMAHHLYVLQALMLGLLEPRMRTPLDPYSQEQREQLQVLRQAAFEVEGESSGAGLSADRRRSLCAREFRKLGFSNSNPAQDLERVPPGLLALDNMLYFSRNAPSAYSRFVLENSSREDKHECPFARGSIQLTVLLCELLRVGEPCSETAQDFSPMFFGQDQSFHELFCVGIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPTSLELFRTKVNALTYGEVLRLRQTERLHQEGTLAPPILELREKLKPELMGLIRQQRLLRLCEGTLFRKISSRRRQDKLWFCCLSPNHKLLQYGDMEEGASPPTLESLPEQLPVADMRALLTGKDCPHVREKGSGKQNKDLYELAFSISYDRGEEEAYLNFIAPSKREFYLWTDGLSALLGSPMGSEQTRLDLEQLLTMETKLRLLELENVPIPERPPPVPPPPTNFNFCYDCSIAEP", "length": 720 }, "evidence": [ { "id": "A6QR40", "url": "https://omabrowser.org/oma/group/A6QR40/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A6QR40", "url": "https://www.uniprot.org/uniprotkb/A6QR40" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "A6QR40", "url": "https://www.uniprot.org/uniprotkb/A6QR40" } ], "pmid": "" }, { "name": "phagocytosis", "id": "GO:0006909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006909", "evidence": [ { "database": "UniProtKB", "id": "A6QR40", "url": "https://www.uniprot.org/uniprotkb/A6QR40" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A6QR40", "url": "https://www.uniprot.org/uniprotkb/A6QR40" } ], "pmid": "" }, { "name": "cell motility", "id": "GO:0048870", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048870", "evidence": [ { "database": "UniProtKB", "id": "A6QR40", "url": "https://www.uniprot.org/uniprotkb/A6QR40" } ], "pmid": "" }, { "name": "regulation of vasculogenesis", "id": "GO:2001212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001212", "evidence": [ { "database": "UniProtKB", "id": "A6QR40", "url": "https://www.uniprot.org/uniprotkb/A6QR40" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "A6QR40", "url": "https://www.uniprot.org/uniprotkb/A6QR40" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 389, "end_pos": 391, "annotation": "n_glycosylation_sequon" }, { "start_pos": 451, "end_pos": 453, "annotation": "n_glycosylation_sequon" }, { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A6QR40-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 652, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A6QR40-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A6QR40" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A6QR40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QR40" }, { "id": "PRU00664", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00664" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ELMO", "eco_id": "ECO_0000255", "start_pos": 307, "end_pos": 479, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 586 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 195, "end_pos": 197 }, { "start_pos": 389, "end_pos": 391 }, { "start_pos": 451, "end_pos": 453 }, { "start_pos": 71, "end_pos": 73 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDE7-1", "uniprot_ac": "E1BDE7", "uniprot_id": "E1BDE7_BOVIN", "mass": { "chemical_mass": 118455.0, "monoisotopic_mass": 118455.0 }, "refseq": {}, "gene_names": [ { "name": "SAFB2", "type": "recommended", "evidence": [ { "id": "E1BDE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDE7" } ] } ], "protein_names": [ { "name": "Scaffold attachment factor B2", "type": "synonym", "evidence": [ { "id": "E1BDE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDE7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDE7", "url": "https://www.uniprot.org/uniprotkb/E1BDE7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SAFB2", "url": "https://www.uniprot.org/uniprotkb/E1BDE7", "locus": { "chromosome": "7", "start_pos": 18711822, "end_pos": 18682517, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001790", "url": "https://www.ensembl.org/id/ENSBTAG00000001790" } ] } } ], "crossref": [ { "id": "E1BDE7", "url": "https://alphafold.ebi.ac.uk/entry/E1BDE7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001790", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001790", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000051794", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051794", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12679", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12679", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051738", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051738", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BDE7", "url": "https://www.orthodb.org/?gene=E1BDE7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15683", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15683", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15683:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15683:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02037", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02037", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MU58", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU58", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MU58-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU58-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1Z4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1Z4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDE7", "url": "https://www.uniprot.org/uniprotkb/E1BDE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDE7-1", "url": "https://www.uniprot.org/uniprotkb/E1BDE7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSESPVSEVQGALRLAGLPPRTAKTLTYSNYSACALLPRACGWSMRERPTAAKNAYSGGARARPEKGAGGSQCVFLSGGAILCSEPLQPPAVWEVVGADSIPGMAETLAGSSDSGSGTAAVVSGVSEVGTRRLSDLRVIDLRAELKKRNLDTGGNKSVLMERLKKAVKEEGQDPDEIGIALEATSKKTKRFVKEQKAEEEGTEDNGLEEDSRDGQEDMEASLEGLQSIDMMDVNVLEETEVENSAVPDFGEDGTDSILESLCESKDYVATQLRELPAQFTGHAVDGEGFENTLDASSLDFKVPPDIEEPLLEPENEKILDILGETCKSEPVKEEGSELEQPFAQETSSVGPDRKLAEEEDLFDSAHPEEGDLDLANESTAHAQSSKADTLLAVVKREPVEQTGDDERTDCEPVGLEKPIEQSSKASEHTEACSEEAAEAPPEASSPDPGDSKEDVKKFAFEACNEVPPAPKESSASEGADQKMSSFKEEKDIKPIVKDEKGRISNSSGRNLWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTSDEATKCISHLHRTELHGRMISVEKAKNEPSGKKLSDRKECEVKKEKLSSVDRHHSVEIKVEKTIVKKEEKMEKKEEKEPEDIKKEEKDENELKSGPENRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAFHEGKEKARLEREREQLDRQWQRLERERLERERLERERERVERERRREQERIQREREELRHQQEQLRYEQERRSVVRRPYDIGRRDDAYWPEGKRMAMEDRYRPDFPRPDHRFHHFDYRDRGRYQEHVADRREGSRSVMGERDGQHYSDERHSHGGPPERHARDSRDGWGGYGSDKRMSEGRGPPPPPRGGRDWSEHSQRLEEHQERTWPGTVDTDTAGREHSRWQGGERGLSGPSGPGHMADRGGISGRGGFAHSGHTQGDVVPAGGLDSDGLAGQDRGDRDPHPHQYPHFTRSY", "length": 1052, "header": "tr|E1BDE7-1|E1BDE7_BOVIN Isoform 1 of Scaffold attachment factor B2 OS=Bos taurus OX=9913 GN=SAFB2 PE=4 SV=4 CANONICAL=E1BDE7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MU58-1", "url": "https://www.uniprot.org/uniprotkb/E1BDE7/entry#A0A3Q1MU58-1", "sequence": { "sequence": "MRSESPVSEVQGALRLAGLPPRTAKTLTYSNYSACALLPRACGWSMRERPTAAKNAYSGGARARPEKGAGGSQCVFLSGGAILCSEPLQPPAVWEVVGADSIPGMAETLAGSSDSGSGTAAVVSGVSEVGTRRLSDLRVIDLRAELKKRNLDTGGNKSVLMERLKKAVKEEGQDPDEIGIALEATSKKTKRFVKEQKAEEEGTEDNGLEEDSRDGQEDMEASLEGLQSIDMMDVNVLEETEVENSAVPDFGEDGTDSILESLCESKDYVATQLRELPAQFTGHAVDGEGFENTLDASSLDFKVPPDIEEPLLEPENEKILDILGETCKSEPVKEEGSELEQPFAQETSSVGPDRKLAEEEDLFDSAHPEEGDLDLANESTAHAQSSKADTLLAVVKREPVEQTGDDERTDCEPVGLEKPIEQSSKASEHTEACSEEAAEAPPEASSPDPGDSKEDVKKFAFEACNEVPPAPKESSASEGADQKMSSFKEEKDIKPIVKDEKGRISNSSGRNLWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTSDEATKCISHLHRTELHGRMISVEKAKNEPSGKKLSDRKECEVKKEKLSSVDRHHSVEIKVEKTIVKKEEKMEKKEEKEPEDIKKEEKDENELKSGPENRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAFHEGKEKARLEREREQLDRQWQRLERERLERERLERERERVERERRREQERIQREREELRHQQEQLRYEQERRSVVRRPYDIGRRDDAYWPEGKRMAMEDRYRPDFPRPDHRFHHFDYRDRGRYQEHVADRGGRDWSEHSQRLEEHQERTWPGTVDTDTAGREHSRWQGGERGLSGPSGPGHMADRGGISGRGGFAHSGHTQGDVVPAGGLDSDGLAGQDRGDRDPHPHQYPHFTRSY", "length": 994, "header": "tr|A0A3Q1MU58-1|E1BDE7_BOVIN Computationally mapped isoform of Scaffold attachment factor B2 OS=Bos taurus OX=9913 GN=SAFB2 PE=4 SV=2 CANONICAL=E1BDE7-1" }, "locus": { "chromosome": "7", "start_pos": 18711584, "end_pos": 18682716, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072629.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072629.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074066.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074066.2" } ] } }, { "isoform_ac": "A0AAA9S1Z4-1", "url": "https://www.uniprot.org/uniprotkb/E1BDE7/entry#A0AAA9S1Z4-1", "sequence": { "sequence": "MRSESPVSEVQGALRLAGLPPRTAKTLTYSNYSACALLPRACGWSMRERPTAAKNAYSGGARARPEKGAGGSQCVFLSGGAILCSEPLQPPAVWEVVGADSIPGMAETLAGSSDSGSGTAAVVSGVSEVGTRRLSDLRVIDLRAELKKRNLDTGGNKSVLMERLKKAVKEEGQDPDEIGIALEATSKKTKRFVKEQKAEEEGTEDNGLEEDSRDGQEDMEASLEGLQSIDMMDVNVLEETEVENSAVPDFGEDGTDSILESLCESKDYVATQLRELPAQFTGHAVDGEGFENTLDASSLDFKVPPDIEEPLLEPENEKILDILGETCKSEPVKEEGSELEQPFAQETSSVGPDRKLAEEEDLFDSAHPEEGDLDLANESTAHAQSSKADTLLAVVKREPVEQTGDDERTDCEPVGLEKPIEQSSKASEHTEACSEEAAEAPPEASSPDPGDSKEDVKKFAFEACNEVPPAPKESSASEGADQKMSSFKEEKDIKPIVKDEKGRISNSSGRNLWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTSDEATKCISHLHRTELHGRMISVEKAKNEPSGKKLSDRKECEVKKEKLSSVDRHHSVEIKVEKTIVKKEEKMEKKEEKEPEDIKKEEKDENELKSGPENRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAFHEGKEKARLEREREQLDRQWQRLERERLERERLERERERVERERRREQERIQREREELRHQQEQLRYEQERRSVVRRPYDIGRRDDAYWPEGKRMAMEDRYRPDFPRPDHRFHHFDYRDRGRYQEHVADRREGSRSVMGERDGQHYSDERHSHGGPPERHARDSRDGWGGYGSDKRMSEGRGPPPPPRCFPSVESHTVCLCLLLSVSIMSSRGGRDWSEHSQRLEEHQERTWPGTVDTDTAGREHSRWQGGERGLSGPSGPGHMADRGGISGRGGFAHSGHTQGDVVPAGGLDSDGLAGQDRGDRDPHPHQYPHFTRSY", "length": 1076, "header": "tr|A0AAA9S1Z4-1|E1BDE7_BOVIN Computationally mapped isoform of Scaffold attachment factor B2 OS=Bos taurus OX=9913 GN=SAFB2 PE=4 SV=1 CANONICAL=E1BDE7-1" }, "locus": { "chromosome": "7", "start_pos": 18711584, "end_pos": 18682716, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095232.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095232.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077333.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077333.1" } ] } }, { "isoform_ac": "E1BDE7-1", "url": "https://www.uniprot.org/uniprotkb/E1BDE7/entry#E1BDE7-1", "sequence": { "sequence": "MRSESPVSEVQGALRLAGLPPRTAKTLTYSNYSACALLPRACGWSMRERPTAAKNAYSGGARARPEKGAGGSQCVFLSGGAILCSEPLQPPAVWEVVGADSIPGMAETLAGSSDSGSGTAAVVSGVSEVGTRRLSDLRVIDLRAELKKRNLDTGGNKSVLMERLKKAVKEEGQDPDEIGIALEATSKKTKRFVKEQKAEEEGTEDNGLEEDSRDGQEDMEASLEGLQSIDMMDVNVLEETEVENSAVPDFGEDGTDSILESLCESKDYVATQLRELPAQFTGHAVDGEGFENTLDASSLDFKVPPDIEEPLLEPENEKILDILGETCKSEPVKEEGSELEQPFAQETSSVGPDRKLAEEEDLFDSAHPEEGDLDLANESTAHAQSSKADTLLAVVKREPVEQTGDDERTDCEPVGLEKPIEQSSKASEHTEACSEEAAEAPPEASSPDPGDSKEDVKKFAFEACNEVPPAPKESSASEGADQKMSSFKEEKDIKPIVKDEKGRISNSSGRNLWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTSDEATKCISHLHRTELHGRMISVEKAKNEPSGKKLSDRKECEVKKEKLSSVDRHHSVEIKVEKTIVKKEEKMEKKEEKEPEDIKKEEKDENELKSGPENRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAFHEGKEKARLEREREQLDRQWQRLERERLERERLERERERVERERRREQERIQREREELRHQQEQLRYEQERRSVVRRPYDIGRRDDAYWPEGKRMAMEDRYRPDFPRPDHRFHHFDYRDRGRYQEHVADRREGSRSVMGERDGQHYSDERHSHGGPPERHARDSRDGWGGYGSDKRMSEGRGPPPPPRGGRDWSEHSQRLEEHQERTWPGTVDTDTAGREHSRWQGGERGLSGPSGPGHMADRGGISGRGGFAHSGHTQGDVVPAGGLDSDGLAGQDRGDRDPHPHQYPHFTRSY", "length": 1052, "header": "tr|E1BDE7-1|E1BDE7_BOVIN Isoform 1 of Scaffold attachment factor B2 OS=Bos taurus OX=9913 GN=SAFB2 PE=4 SV=4 CANONICAL=E1BDE7-1" }, "locus": { "chromosome": "7", "start_pos": 18711584, "end_pos": 18682716, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044703.5", "url": "https://www.ensembl.org/id/ENSBTAT00000044703.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042180.5", "url": "https://www.ensembl.org/id/ENSBTAP00000042180.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BDE7", "url": "https://www.uniprot.org/uniprotkb/E1BDE7" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BDE7", "url": "https://www.uniprot.org/uniprotkb/E1BDE7" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BDE7", "url": "https://www.uniprot.org/uniprotkb/E1BDE7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BDE7", "url": "https://www.uniprot.org/uniprotkb/E1BDE7" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "E1BDE7", "url": "https://www.uniprot.org/uniprotkb/E1BDE7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BDE7", "url": "https://www.uniprot.org/uniprotkb/E1BDE7" } ], "pmid": "" }, { "name": "regulation of androgen receptor signaling pathway", "id": "GO:0060765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060765", "evidence": [ { "database": "UniProtKB", "id": "E1BDE7", "url": "https://www.uniprot.org/uniprotkb/E1BDE7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" }, { "start_pos": 377, "end_pos": 379, "annotation": "n_glycosylation_sequon" }, { "start_pos": 506, "end_pos": 508, "annotation": "n_glycosylation_sequon" }, { "start_pos": 659, "end_pos": 661, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDE7" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 510, "end_pos": 588, "start_aa": "Arg", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BDE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDE7" }, { "id": "PS50800", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50800" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAP", "eco_id": "ECO_0000259", "start_pos": 134, "end_pos": 168, "start_aa": "Leu", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 156, "end_pos": 158 }, { "start_pos": 31, "end_pos": 33 }, { "start_pos": 377, "end_pos": 379 }, { "start_pos": 506, "end_pos": 508 }, { "start_pos": 659, "end_pos": 661 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A7YWH3-1", "uniprot_ac": "A7YWH3", "uniprot_id": "KCD19_BOVIN", "mass": { "chemical_mass": 105078.0, "monoisotopic_mass": 105078.0 }, "refseq": { "ac": "NP_001098862", "name": "BTB/POZ domain-containing protein KCTD19", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098862" }, "gene_names": [ { "name": "KCTD19", "type": "recommended", "evidence": [ { "id": "A7YWH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWH3" } ] }, { "name": "KCTD19", "type": "synonym", "evidence": [ { "id": "NP_001098862", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098862" } ] } ], "protein_names": [ { "name": "BTB/POZ domain-containing protein KCTD19", "type": "recommended", "evidence": [ { "id": "A7YWH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWH3/entry#names_and_taxonomy" } ] }, { "name": "BTB/POZ domain-containing protein KCTD19", "type": "synonym", "evidence": [ { "id": "NP_001098862", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098862" } ] }, { "name": "potassium channel tetramerisation domain containing 19", "type": "synonym", "evidence": [ { "id": "NP_001098862", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098862" } ] } ], "function": [ { "annotation": "Transcription regulator which is essential for male fertility and for the completion of meiotic prophase in spermatocytes. Regulates progression of the pachytene stage of meiotic prophase and promotes the transcriptional activation activity ZNF541. Required for the organization of chromosomes during metaphase I.", "evidence": [ { "database": "UniProtKB", "id": "A7YWH3", "url": "https://www.uniprot.org/uniprotkb/A7YWH3#function" }, { "database": "UniProtKB", "id": "Q562E2", "url": "https://www.uniprot.org/uniprotkb/Q562E2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7YWH3", "url": "https://www.uniprot.org/uniprotkb/A7YWH3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCTD19", "url": "https://www.uniprot.org/uniprotkb/A7YWH3", "locus": { "chromosome": "18", "start_pos": 34909015, "end_pos": 34933955, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032396", "url": "https://www.ensembl.org/id/ENSBTAG00000032396" } ] } } ], "crossref": [ { "id": "A7YWH3", "url": "https://alphafold.ebi.ac.uk/entry/A7YWH3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032396", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032396", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18373", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18373", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18374", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18374", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523858", "url": "https://www.ncbi.nlm.nih.gov/gene/523858", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523858", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523858", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DJC0", "url": "https://www.orthodb.org/?gene=A0A452DJC0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A7YWH3", "url": "https://www.orthodb.org/?gene=A7YWH3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001098862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098862", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DJC0", "url": "https://www.uniprot.org/uniprotkb/A0A452DJC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJC0-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJC0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7YWH3", "url": "https://www.uniprot.org/uniprotkb/A7YWH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7YWH3-1", "url": "https://www.uniprot.org/uniprotkb/A7YWH3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEPGMPHESAEDLFHFNVGGWHFSVPRSKLAQFPDSLLWKEASALTSSENQRLFIDRDGSTFRHVHYYLYTSKLSFSSCAELNLLYEQALGLQLMPLLQTLDNLKEGKHHLRVRPADIPVAERASLNYWRTWKCISKPSEFPIKSPAFTGLHDKAPLGLMDTPLLDTEEEVHYCFLPLDLVAKHPSLVTEDNLLWLAETMALIECECSEFRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEIPELSEAVRLYRMNMGGCSRTSCPPPSPGKGGRSAGLESVKPLYMMALGLLVKYPDSALGQLRIESTLDGSRLYITGNGVLFQHVKNWLGTCRLPLTETVSEVYELCAFLDKRDITYEPMKVALKTHLEPRTLAPMDVLNEEWTAEITVYSSQQIIKVYVGSHWYATTLQTLLKYPELLSNPQRVYWITYGQTLLIYGDGQMFRHILNFLRLGKLFLPTEFKEWPLLCQEVEEYHIPSLSEALVQCEAYKSWIQEKESENEEAFPIRRLHVVTEGPGSLVEFSRDTKETMACVPMEFQDCNDRTMWNKAKGTLARSSQIEEAEQYSQTIQMSLCRGAKRAGNPSTYSHCPGLCANPRHWGGHPESPPKKKCTTVNLTQKPETKDPPVTPMQKLISLVREWDMVNCKQWEFQSLPAPRNSSLEEATLQHSSGSEAVSQPSTSASWKGHSTASEKDPGPQAGAGAGTKDKGPEPNFNPYFPMKRAVALKDWGKQRSKERENPAFELTLPEASEGDNTGVILKVTHPPVVGSDGSCMFFEDSIIYTTHMDHLRRTPPPASPQPREVTFLSFSLSWEEMFYAQKCHCFLTDIILDSIRQNDPKAITAKVVSLVNQLWTLHISPKQFVVDLLAITGFKDDRHTQERLYSWVELTLPFARKYGRCVDLLIQRGLSKSVSYSVLSKYLQDG", "length": 927, "header": "sp|A7YWH3-1|KCD19_BOVIN Isoform 1 of BTB/POZ domain-containing protein KCTD19 OS=Bos taurus OX=9913 GN=KCTD19 PE=2 SV=1 CANONICAL=A7YWH3-1" }, "isoforms": [ { "isoform_ac": "A0A452DJC0-1", "url": "https://www.uniprot.org/uniprotkb/A7YWH3/entry#A0A452DJC0-1", "sequence": { "sequence": "MGEEPGMPHESAEDLFHFNVGGWHFSVPRSKLAQFPDSLLWKEASALTSSENQRLFIDRDGSTFRHVHYYLYTSKLSFSSCAELNLLYEQALGLQLMPLLQTLDNLKEGKHHLRVRPADIPVAERASLNYWRTWKCISKPSEFPIKSPAFTGLHDKAPLGLMDTPLLDTEEEVHYCFLPLDLVAKHPSLVTEDNLLWLAETMALIECECSEFRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEIPELSEAVRLYRMNMGGCSRTSCPPPKSVKPLYMMALGLLVKYPDSALGQLRIESTLDGSRLYITGNGVLFQHVKNWLGTCRLPLTETVSEVYELCAFLDKRDITYEPMKVALKTHLEPRTLAPMDVLNEEWTAEITVYSSQQIIKVYVGSHWYATTLQTLLKYPELLSNPQRVYWITYGQTLLIYGDGQMFRHILNFLRLGKLFLPTEFKEWPLLCQEVEEYHIPSLSEALVQCEAYKSWIQEKESENEEAFPIRRLHVVTEGPGSLVEFSRDTKETMACVPMEFQDCNDRTMWNKAKGTLARSSQIEEAEQYSQTIQMSLCRGAKRAGNPSTYSHCPGLCANPRHWGGHPESPPKKKCTTVNLTQKPETKDPPVTPMQKLISLVREWDMVNCKQWEFQSLPAPRNSSLEEATLQHSSGSEAVSQPSTSASWKGHSTASEKDPGPQAGAGAGTKDKGPEPNFNPYFPMKRAVALKDWGKQRSKERENPAFELTLPEASEGDNTGVILKVTHPPVVGSDGSCMFFEDSIIYTTHMDHLRRTPPPASPQPREVTFLSFSLSWEEMFYAQKCHCFLTDIILDSIRQNDPKAITAKVVSLVNQLWTLHISPKQFVVDLLAITGFKDDRHTQERLYSWVELTLPFARKYGRCVDLLIQRGLSKSVSYSVLSKYLQDG", "length": 917, "header": "tr|A0A452DJC0-1|KCD19_BOVIN Computationally mapped isoform of BTB/POZ domain-containing protein KCTD19 OS=Bos taurus OX=9913 GN=KCTD19 PE=2 SV=2 CANONICAL=A7YWH3-1" }, "locus": { "chromosome": "18", "start_pos": 34933955, "end_pos": 34909159, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045955.5", "url": "https://www.ensembl.org/id/ENSBTAT00000045955.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043298.5", "url": "https://www.ensembl.org/id/ENSBTAP00000043298.5" } ] } }, { "isoform_ac": "A7YWH3-1", "url": "https://www.uniprot.org/uniprotkb/A7YWH3/entry#A7YWH3-1", "sequence": { "sequence": "MEEPGMPHESAEDLFHFNVGGWHFSVPRSKLAQFPDSLLWKEASALTSSENQRLFIDRDGSTFRHVHYYLYTSKLSFSSCAELNLLYEQALGLQLMPLLQTLDNLKEGKHHLRVRPADIPVAERASLNYWRTWKCISKPSEFPIKSPAFTGLHDKAPLGLMDTPLLDTEEEVHYCFLPLDLVAKHPSLVTEDNLLWLAETMALIECECSEFRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEIPELSEAVRLYRMNMGGCSRTSCPPPSPGKGGRSAGLESVKPLYMMALGLLVKYPDSALGQLRIESTLDGSRLYITGNGVLFQHVKNWLGTCRLPLTETVSEVYELCAFLDKRDITYEPMKVALKTHLEPRTLAPMDVLNEEWTAEITVYSSQQIIKVYVGSHWYATTLQTLLKYPELLSNPQRVYWITYGQTLLIYGDGQMFRHILNFLRLGKLFLPTEFKEWPLLCQEVEEYHIPSLSEALVQCEAYKSWIQEKESENEEAFPIRRLHVVTEGPGSLVEFSRDTKETMACVPMEFQDCNDRTMWNKAKGTLARSSQIEEAEQYSQTIQMSLCRGAKRAGNPSTYSHCPGLCANPRHWGGHPESPPKKKCTTVNLTQKPETKDPPVTPMQKLISLVREWDMVNCKQWEFQSLPAPRNSSLEEATLQHSSGSEAVSQPSTSASWKGHSTASEKDPGPQAGAGAGTKDKGPEPNFNPYFPMKRAVALKDWGKQRSKERENPAFELTLPEASEGDNTGVILKVTHPPVVGSDGSCMFFEDSIIYTTHMDHLRRTPPPASPQPREVTFLSFSLSWEEMFYAQKCHCFLTDIILDSIRQNDPKAITAKVVSLVNQLWTLHISPKQFVVDLLAITGFKDDRHTQERLYSWVELTLPFARKYGRCVDLLIQRGLSKSVSYSVLSKYLQDG", "length": 927, "header": "sp|A7YWH3-1|KCD19_BOVIN Isoform 1 of BTB/POZ domain-containing protein KCTD19 OS=Bos taurus OX=9913 GN=KCTD19 PE=2 SV=1 CANONICAL=A7YWH3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 270, "end_pos": 270, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7YWH3", "url": "https://www.uniprot.org/uniprotkb/A7YWH3" } ], "site_lbl": "Ser270" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:523858", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523858", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A7YWH3", "url": "https://www.uniprot.org/uniprotkb/A7YWH3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A7YWH3", "url": "https://www.uniprot.org/uniprotkb/A7YWH3" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A7YWH3", "url": "https://www.uniprot.org/uniprotkb/A7YWH3" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A7YWH3", "url": "https://www.uniprot.org/uniprotkb/A7YWH3" } ], "pmid": "" }, { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "A7YWH3", "url": "https://www.uniprot.org/uniprotkb/A7YWH3" } ], "pmid": "" }, { "name": "male meiotic nuclear division", "id": "GO:0007140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007140", "evidence": [ { "database": "UniProtKB", "id": "A7YWH3", "url": "https://www.uniprot.org/uniprotkb/A7YWH3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" }, { "start_pos": 618, "end_pos": 620, "annotation": "n_glycosylation_sequon" }, { "start_pos": 661, "end_pos": 663, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7YWH3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 927, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7YWH3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7YWH3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 270 ], "sequon_annotation_sites": [ { "start_pos": 228, "end_pos": 230 }, { "start_pos": 618, "end_pos": 620 }, { "start_pos": 661, "end_pos": 663 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B7R3-1", "uniprot_ac": "E1B7R3", "uniprot_id": "E1B7R3_BOVIN", "mass": { "chemical_mass": 54515.0, "monoisotopic_mass": 54515.0 }, "refseq": { "ac": "NP_001192903", "name": "sialin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192903" }, "gene_names": [ { "name": "SLC17A5", "type": "recommended", "evidence": [ { "id": "E1B7R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7R3" } ] }, { "name": "SLC17A5", "type": "synonym", "evidence": [ { "id": "NP_001192903", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192903" } ] } ], "protein_names": [ { "name": "Sialin", "type": "recommended", "evidence": [ { "id": "E1B7R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7R3/entry#names_and_taxonomy" } ] }, { "name": "H(+)/nitrate cotransporter", "type": "synonym", "evidence": [ { "id": "E1B7R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7R3/entry#names_and_taxonomy" } ] }, { "name": "H(+)/sialic acid cotransporter", "type": "synonym", "evidence": [ { "id": "E1B7R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7R3/entry#names_and_taxonomy" } ] }, { "name": "Vesicular excitatory amino acid transporter", "type": "synonym", "evidence": [ { "id": "E1B7R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7R3/entry#names_and_taxonomy" } ] }, { "name": "sialin", "type": "synonym", "evidence": [ { "id": "NP_001192903", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192903" } ] }, { "name": "solute carrier family 17 (anion/sugar transporter), member 5", "type": "synonym", "evidence": [ { "id": "NP_001192903", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192903" } ] } ], "function": [ { "annotation": "Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9U0I2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0I2#function" }, { "database": "UniProtKB", "id": "ARBA00056891", "url": "https://www.uniprot.org/uniprotkb/ARBA00056891#function" }, { "database": "UniProtKB", "id": "A0AAA9TG64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG64#function" }, { "database": "UniProtKB", "id": "E1B7R3", "url": "https://www.uniprot.org/uniprotkb/E1B7R3#function" }, { "database": "UniProtKB", "id": "A0AAA9SLN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN1#function" }, { "database": "UniProtKB", "id": "A0AAA9RXL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXL2#function" }, { "database": "UniProtKB", "id": "A0AAA9SYF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYF8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7R3", "url": "https://www.uniprot.org/uniprotkb/E1B7R3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC17A5", "url": "https://www.uniprot.org/uniprotkb/E1B7R3", "locus": { "chromosome": "9", "start_pos": 13086269, "end_pos": 13162393, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044053", "url": "https://www.ensembl.org/id/ENSBTAG00000044053" } ] } } ], "crossref": [ { "id": "E1B7R3", "url": "https://alphafold.ebi.ac.uk/entry/E1B7R3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044053", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044053", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17381", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17381", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "530164", "url": "https://www.ncbi.nlm.nih.gov/gene/530164", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050382", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050382", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530164", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530164", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RVVTTWF", "url": "https://omabrowser.org/oma/group/RVVTTWF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7R3", "url": "https://www.orthodb.org/?gene=E1B7R3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11662", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11662", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11662:SF432", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11662:SF432", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2160916", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2160916", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4085001", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4085001", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-428643", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-428643", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192903", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192903", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "28987", "url": "https://www.rhea-db.org/rhea/28987", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66332", "url": "https://www.rhea-db.org/rhea/66332", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66336", "url": "https://www.rhea-db.org/rhea/66336", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "71539", "url": "https://www.rhea-db.org/rhea/71539", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "72591", "url": "https://www.rhea-db.org/rhea/72591", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "72599", "url": "https://www.rhea-db.org/rhea/72599", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RXL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXL2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYF8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYF8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYF8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG64-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0I2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0I2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0I2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0I2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7R3", "url": "https://www.uniprot.org/uniprotkb/E1B7R3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7R3-1", "url": "https://www.uniprot.org/uniprotkb/E1B7R3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKSPVSDLAPSDGEEGSDRTPLLQRAPRAETAPVCCSARYNLAFLSFFGFFVLYSLRVNLSVALVDMVDSNTTAKDNRTSYECAEHSAPIKVLRNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASRSGGKLLLGFGVLGTAVFTLFTPLAADFGFGALVALRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVVSLPLSGVICYYMNWTYVFYFFGLVGIIWFILWICLVSDTPETHKTITPYEKEYILSSLKNQLSSQKSVPWIPMLKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEVLRFNIQENGFLSAVPYLGCWLCMILSGQAADNLRARWNFSTLWVRRVFSLIGMIGPAIFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMIGPIIARSLTPENTIGEWQTVFCIAAAINVFGAIFFTLFAKGEVQNWAISDHRGHRN", "length": 495, "header": "tr|E1B7R3-1|E1B7R3_BOVIN Isoform 1 of Sialin OS=Bos taurus OX=9913 GN=SLC17A5 PE=4 SV=1 CANONICAL=E1B7R3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXL2-1", "url": "https://www.uniprot.org/uniprotkb/E1B7R3/entry#A0AAA9RXL2-1", "sequence": { "sequence": "MKSPVSDLAPSDGEEGSDRTPLLQRAPRAETGDLPNPGIKPASPASPELAAPVCCSARYNLAFLSFFGFFVLYSLRVNLSVALVDMVDSNTTAKDNRTSYECAEHSAPIKVLRNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASRSGGKLLLGFGVLGTAVFTLFTPLAADFGFGALVALRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVVSLPLSGVICYYMNWTYVFYFFGLVGIIWFILWICLVSDTPETHKTITPYEKEYILSSLKNQLSSQKSVPWIPMLKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEVLRFNIQENGFLSAVPYLGCWLCMILSGQAADNLRARWNFSTLWVRRVFSLIGMIGPAIFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMIGPIIARSLTPENTIGEWQTVFCIAAAINVFGAIFFTLFAKGEVQNWAISDHRGHRN", "length": 514, "header": "tr|A0AAA9RXL2-1|E1B7R3_BOVIN Computationally mapped isoform of Sialin OS=Bos taurus OX=9913 GN=SLC17A5 PE=4 SV=1 CANONICAL=E1B7R3-1" }, "locus": { "chromosome": "9", "start_pos": 13161299, "end_pos": 13086917, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116363.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116363.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075946.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075946.1" } ] } }, { "isoform_ac": "A0AAA9SLN1-1", "url": "https://www.uniprot.org/uniprotkb/E1B7R3/entry#A0AAA9SLN1-1", "sequence": { "sequence": "MARRARTAHRSCSAPRGRKPPCGQRSLAGYSPWGHKESDATERTRQALLFMEFSRQEYWSELPFPPPGDLPNPGIKPASPASPELAAPVCCSARYNLAFLSFFGFFVLYSLRVNLSVALVDMVDSNTTAKDNRTSYECAEHSAPIKVLRNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASRSGGKLLLGFGVLGTAVFTLFTPLAADFGFGALVALRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVVSLPLSGVICYYMNWTYVFYFFGLVGIIWFILWICLVSDTPETHKTITPYEKEYILSSLKNQLSSQKSVPWIPMLKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEVLRFNIQENGFLSAVPYLGCWLCMILSGQAADNLRARWNFSTLWVRRVFSLIGMIGPAIFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMIGPIIARSLTPENTIGEWQTVFCIAAAINVFGAIFFTLFAKGEVQNWAISDHRGHRN", "length": 550, "header": "tr|A0AAA9SLN1-1|E1B7R3_BOVIN Computationally mapped isoform of Sialin OS=Bos taurus OX=9913 GN=SLC17A5 PE=4 SV=1 CANONICAL=E1B7R3-1" }, "locus": { "chromosome": "9", "start_pos": 13161265, "end_pos": 13086917, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113411.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113411.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084826.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084826.1" } ] } }, { "isoform_ac": "A0AAA9SYF8-1", "url": "https://www.uniprot.org/uniprotkb/E1B7R3/entry#A0AAA9SYF8-1", "sequence": { "sequence": "MKSPVSDLAPSDGEEGSDRTPLLQRAPRAETASEDGFQAPVCCSARYNLAFLSFFGFFVLYSLRVNLSVALVDMVDSNTTAKDNRTSYECAEHSAPIKVLRNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASRSGGKLLLGFGVLGTAVFTLFTPLAADFGFGALVALRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVVSLPLSGVICYYMNWTYVFYFFGLVGIIWFILWICLVSDTPETHKTITPYEKEYILSSLKNQLSSQKSVPWIPMLKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEVLRFNIQENGFLSAVPYLGCWLCMILSGQAADNLRARWNFSTLWVRRVFSLIGMIGPAIFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMIGPIIARSLTPENTIGEWQTVFCIAAAINVFGAIFFTLFAKGEVQNWAISDHRGHRN", "length": 502, "header": "tr|A0AAA9SYF8-1|E1B7R3_BOVIN Computationally mapped isoform of Sialin OS=Bos taurus OX=9913 GN=SLC17A5 PE=4 SV=1 CANONICAL=E1B7R3-1" }, "locus": { "chromosome": "9", "start_pos": 13161299, "end_pos": 13086917, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101413.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101413.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091497.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091497.1" } ] } }, { "isoform_ac": "A0AAA9TG64-1", "url": "https://www.uniprot.org/uniprotkb/E1B7R3/entry#A0AAA9TG64-1", "sequence": { "sequence": "MEFSRQEYWSELPFPPPGDLPNPGIKPASPASPELAASEDGFQAPVCCSARYNLAFLSFFGFFVLYSLRVNLSVALVDMVDSNTTAKDNRTSYECAEHSAPIKVLRNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASRSGGKLLLGFGVLGTAVFTLFTPLAADFGFGALVALRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVVSLPLSGVICYYMNWTYVFYFFGLVGIIWFILWICLVSDTPETHKTITPYEKEYILSSLKNQLSSQKSVPWIPMLKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEVLRFNIQENGFLSAVPYLGCWLCMILSGQAADNLRARWNFSTLWVRRVFSLIGMIGPAIFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMIGPIIARSLTPENTIGEWQTVFCIAAAINVFGAIFFTLFAKGEVQNWAISDHRGHRN", "length": 507, "header": "tr|A0AAA9TG64-1|E1B7R3_BOVIN Computationally mapped isoform of Sialin OS=Bos taurus OX=9913 GN=SLC17A5 PE=4 SV=1 CANONICAL=E1B7R3-1" }, "locus": { "chromosome": "9", "start_pos": 13154563, "end_pos": 13086917, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102377.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102377.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095166.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095166.1" } ] } }, { "isoform_ac": "A0AAA9U0I2-1", "url": "https://www.uniprot.org/uniprotkb/E1B7R3/entry#A0AAA9U0I2-1", "sequence": { "sequence": "MTDVAGGRGQTGGGASGPAHPGHLGPGAGGFSGQAGALFSAGQVCAVAPWRRHEVPGFGLGPERWRGGLGPHTAPAARPAGGNRHARLFVTPWTVARQALLFMEFSRQEYWSELPFPPPGDLPNPGIKPASPASPELAAPVCCSARYNLAFLSFFGFFVLYSLRVNLSVALVDMVDSNTTAKDNRTSYECAEHSAPIKVLRNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASRSGGKLLLGFGVLGTAVFTLFTPLAADFGFGALVALRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVVSLPLSGVICYYMNWTYVFYFFGLVGIIWFILWICLVSDTPETHKTITPYEKEYILSSLKNQLSSQKSVPWIPMLKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEVLRFNIQENGFLSAVPYLGCWLCMILSGQAADNLRARWNFSTLWVRRVFSLIGMIGPAIFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMIGPIIARSLTPENTIGEWQTVFCIAAAINVFGAIFFTLFAKGEVQNWAISDHRGHRN", "length": 602, "header": "tr|A0AAA9U0I2-1|E1B7R3_BOVIN Computationally mapped isoform of Sialin OS=Bos taurus OX=9913 GN=SLC17A5 PE=4 SV=1 CANONICAL=E1B7R3-1" }, "locus": { "chromosome": "9", "start_pos": 13161456, "end_pos": 13086917, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114221.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114221.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103441.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103441.1" } ] } }, { "isoform_ac": "E1B7R3-1", "url": "https://www.uniprot.org/uniprotkb/E1B7R3/entry#E1B7R3-1", "sequence": { "sequence": "MKSPVSDLAPSDGEEGSDRTPLLQRAPRAETAPVCCSARYNLAFLSFFGFFVLYSLRVNLSVALVDMVDSNTTAKDNRTSYECAEHSAPIKVLRNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASRSGGKLLLGFGVLGTAVFTLFTPLAADFGFGALVALRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVVSLPLSGVICYYMNWTYVFYFFGLVGIIWFILWICLVSDTPETHKTITPYEKEYILSSLKNQLSSQKSVPWIPMLKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEVLRFNIQENGFLSAVPYLGCWLCMILSGQAADNLRARWNFSTLWVRRVFSLIGMIGPAIFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMIGPIIARSLTPENTIGEWQTVFCIAAAINVFGAIFFTLFAKGEVQNWAISDHRGHRN", "length": 495, "header": "tr|E1B7R3-1|E1B7R3_BOVIN Isoform 1 of Sialin OS=Bos taurus OX=9913 GN=SLC17A5 PE=4 SV=1 CANONICAL=E1B7R3-1" }, "locus": { "chromosome": "9", "start_pos": 13161299, "end_pos": 13086917, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061225.3", "url": "https://www.ensembl.org/id/ENSBTAT00000061225.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053184.2", "url": "https://www.ensembl.org/id/ENSBTAP00000053184.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:530164", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530164", "resource": "KEGG Pathway" }, { "id": "R-BTA-2160916", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2160916", "resource": "Reactome", "description": "Hyaluronan degradation" }, { "id": "R-BTA-4085001", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4085001", "resource": "Reactome", "description": "Sialic acid metabolism" }, { "id": "R-BTA-428643", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-428643", "resource": "Reactome", "description": "Organic anion transport by SLC5/17/25 transporters" } ], "orthologs": [ { "uniprot_canonical_ac": "G3HH38-1", "protein_name": "Sialin", "gene_name": "Slc17a5", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRPLLRGPAVNDEEENSDSTPLLPSARQAEAAPVCCSARYNLAILAFFGFFVLYSLRVNLSVALVDMVDSNTTLTDNRTSKECAEHSAPIKVHRNHTGKKYQWDAETQGWILGSFFYGYIITQIPGGYIASRVGGKLLLGFGILGTAVFTLFTPMAADLGVVALIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIFWFILWMWIVSDTPETHKTISYYEKEYIVSSLKNQLSSQKVVPWTSILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGILSALPYFGCWLCMILCGQAADYLRVKWNFSTISVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMIGPIIAKSLTPDNTIREWQTVFCIAAAINMFGAIVFILFAKGEVQNWALSDHHGHRN", "length": 495 }, "evidence": [ { "id": "E1B7R3", "url": "https://omabrowser.org/oma/group/E1B7R3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O82390-1", "protein_name": "Sodium-dependent phosphate transport protein 1, chloroplastic", "gene_name": "ANTR1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MNARALLCSSNIHSLYTSNRPPEKTSSSRSLRNLKPSPKSLRVWIYPRNRSSVFRVLVRSSDKSESSNSYYVEGDKVSGNNDVVSDSPSSIVLPWWEEFPKRWVIVLLCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTKAESSPLEDPTLLPEERKLIADNCASKEPVKSIPWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLVSRGFSVTNVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGLYSNHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGTVIWNLFSTGEKIID", "length": 512 }, "evidence": [ { "id": "E1B7R3", "url": "https://omabrowser.org/oma/group/E1B7R3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q54UX4-1", "protein_name": "Major facilitator superfamily (MFS) profile domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFKKNVSGDCKNRENGSMADKYQTPRYYFPKRFNLIVLGFLALTVCYTTRTLLSTCVIFMNKEFHYGSTFKGVLLAAFSMGYSTTQLTAQFLCDKFGSKRVILFGLTMSICTLFIVPIAAPYKVAIVLVRIFCGIFQGIVMPSLNLLIANYFPITQRSTCAGMIWAGIYAGNVGISFISPVLLDYLNWRDCFYIVGSVCIVMWVIPWIIFIRDNPKDLFGIHENEIHFINQTAPVEVKLKTLTQSQVVNIKSIMETGNSSRENKEKIINKTENSGNDFKMLHSSSSSTSTVESTTESLNSMVSDEGEQISSTIVEEEKQMKDDERLPYFVAFKKLITSRGMLTIVYLNISCNWAYFLLLGWLPTWLSKELGVNVGYKFAFFNALPFILCLAISVGFGRLSDKLLSMGVRKIILRKTFGGLCYGIPGVFLLMVSLIIPNHSTVIKIAFVTISIAANGFSNTSYQLVTLDLSSKYSGVSMGIANICSAIPAFIGPLVGGFLLESFQGDWNKIFLISSSFYLFGTIVWLIFLKVDNVI", "length": 535 }, "evidence": [ { "id": "E1B7R3", "url": "https://omabrowser.org/oma/group/E1B7R3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8BN82-1", "protein_name": "Sialin", "gene_name": "Slc17a5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRPLLRGPAGNDDEESSDSTPLLPGARQTEAAPVCCSARYNLAILAFCGFFVLYALRVNLSVALVDMVDSNTTLTDNRTSKECAEHSAPIKVHHNHTGKKYKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTISHYEKEYIVSSLKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKWNFSTISVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLFAKGEVQSWALSDHHGHRN", "length": 495 }, "evidence": [ { "id": "E1B7R3", "url": "https://omabrowser.org/oma/group/E1B7R3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NRA2-1", "protein_name": "Sialin", "gene_name": "SLC17A5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRSPVRDLARNDGEESTDRTPLLPGAPRAEAAPVCCSARYNLAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFAKGEVQNWALNDHHGHRH", "length": 495 }, "evidence": [ { "id": "E1B7R3", "url": "https://omabrowser.org/oma/group/E1B7R3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "E1B7R3", "url": "https://www.uniprot.org/uniprotkb/E1B7R3" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "E1B7R3", "url": "https://www.uniprot.org/uniprotkb/E1B7R3" } ], "pmid": "" }, { "name": "synaptic vesicle membrane", "id": "GO:0030672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030672", "evidence": [ { "database": "UniProtKB", "id": "E1B7R3", "url": "https://www.uniprot.org/uniprotkb/E1B7R3" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "E1B7R3", "url": "https://www.uniprot.org/uniprotkb/E1B7R3" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "E1B7R3", "url": "https://www.uniprot.org/uniprotkb/E1B7R3" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "E1B7R3", "url": "https://www.uniprot.org/uniprotkb/E1B7R3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "symporter activity", "id": "GO:0015293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015293", "evidence": [ { "database": "UniProtKB", "id": "E1B7R3", "url": "https://www.uniprot.org/uniprotkb/E1B7R3" } ], "pmid": "" }, { "name": "sialic acid transmembrane transporter activity", "id": "GO:0015136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015136", "evidence": [ { "database": "UniProtKB", "id": "E1B7R3", "url": "https://www.uniprot.org/uniprotkb/E1B7R3" } ], "pmid": "" }, { "name": "D-glucuronate transmembrane transporter activity", "id": "GO:0042880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042880", "evidence": [ { "database": "UniProtKB", "id": "E1B7R3", "url": "https://www.uniprot.org/uniprotkb/E1B7R3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "carboxylic acid transport", "id": "GO:0046942", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046942", "evidence": [ { "database": "UniProtKB", "id": "E1B7R3", "url": "https://www.uniprot.org/uniprotkb/E1B7R3" } ], "pmid": "" }, { "name": "neurotransmitter loading into synaptic vesicle", "id": "GO:0098700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098700", "evidence": [ { "database": "UniProtKB", "id": "E1B7R3", "url": "https://www.uniprot.org/uniprotkb/E1B7R3" } ], "pmid": "" }, { "name": "sialic acid transport", "id": "GO:0015739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015739", "evidence": [ { "database": "UniProtKB", "id": "E1B7R3", "url": "https://www.uniprot.org/uniprotkb/E1B7R3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 302, "end_pos": 304, "annotation": 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"MDVHGRIREILAETIREELAPDQQQLSTEDLIKALKRRGIIDDVMKELNFVTDNVDQELPSSPKQPVCFTDRQSTLLKKTNIDPTRRYLYLQVLGGKAFLEHLQEPEPLPGQACSTFTLCLHFRNQRFRSKPVPCACEPDFHDGFLLEVHRENLGDGTRMADSTTMLSISDPVHMVLIKTDIFAETTLVASYFLEWRSVLGSENGVTNLTVELMGVGTESKVSVGILNIKLEMYPPLNQTLSQEVVNTQLALERQKTAEKERLFLVYAKQWWREYLQIRPSHNSRLVKIFAQDENGINRPVCSYVKPLRAGRLLDTPRQAARFVNVLGYERAPVIGGGGKQEQWCTLLAFLCRNKGDCEDHANLLCSLLLGYGLEAFVCVGTKAKGVPHAWVMTCGTDGTVTFWDSLTGHRYLHKPINPDEPPAAEQPKPLYPYRTIGCVFNHQTFLGNCQPSDSVETCVFDLNDESKWKPMNEEAVKSVCAPGATTSLPPFPPLCASTIDASVTSNEIEMQLRLLVSEHRKDLGLTTVWEDQLSYLLSPALASYEFERTTSISAGNEEFQDAIRRAVPDGHTFKGFPIHFVYRNARRAFATCLRSPFCEEIICCRGDQVRLAVRVRVFTYPESACAVWIMFACKYRSVL", "length": 640, "header": "tr|E1B8D7-1|E1B8D7_BOVIN Isoform 1 of Centrosomal protein of 76 kDa OS=Bos taurus OX=9913 GN=CEP76 PE=3 SV=2 CANONICAL=E1B8D7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXN7-1", "url": "https://www.uniprot.org/uniprotkb/E1B8D7/entry#A0AAA9RXN7-1", "sequence": { "sequence": 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"ENSBTAT00000116969.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116969.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075913.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075913.1" } ] } }, { "isoform_ac": "A0AAA9S644-1", "url": "https://www.uniprot.org/uniprotkb/E1B8D7/entry#A0AAA9S644-1", "sequence": { "sequence": "MSLPPEKASELKQLIHQQLSKMDVHGRIREILAETIREELAPDQQQLSTEDLIKALKRRGIIDDVMKELNFVTDNVDQELPSSPKQPVCFTDRQSTLLKKSDGTRMADSTTMLSISDPVHMVLIKTDIFAETTLVASYFLEWRSVLGSENGVTNLTVELMGVGTESKVSVGILNIKLEMYPPLNQTLSQEVVNTQLALERQKTAEKERLFLVYAKQWWREYLQIRPSHNSRLVKIFAQDENGINRPVCSYVKPLRAGRLLDTPRQAARFVNVLGYERAPVIGGGGKQEQWCTLLAFLCRNKGDCEDHANLLCSLLLGYGLEAFVCVGTKAKGVPHAWVMTCGTDGTVTFWDSLTGHRYLHKPINPDEPPAAEQPKPLYPYRTIGCVFNHQTFLGNCQPSDSVETCVFDLNDESKWKPMNEEAVKSVCAPGATTSLPPFPPLCASTIDASVTSNEIEMQLRLLVSEHRKDLGLTTVWEDQLSYLLSPALASYEFERTTSISAGNEEFQDAIRRAVPDGHTFKGFPIHFVYRNARRAFATCLRSPFCEEIICCRGDQVRLAVRVRVFTYPESACAVWIMFACKYRSVL", "length": 586, "header": "tr|A0AAA9S644-1|E1B8D7_BOVIN Computationally mapped isoform of Centrosomal protein of 76 kDa OS=Bos taurus OX=9913 GN=CEP76 PE=3 SV=1 CANONICAL=E1B8D7-1" }, "locus": { "chromosome": "24", "start_pos": 43072621, "end_pos": 43057927, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125000.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125000.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081410.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081410.1" } ] } }, { "isoform_ac": "E1B8D7-1", "url": "https://www.uniprot.org/uniprotkb/E1B8D7/entry#E1B8D7-1", "sequence": { "sequence": "MDVHGRIREILAETIREELAPDQQQLSTEDLIKALKRRGIIDDVMKELNFVTDNVDQELPSSPKQPVCFTDRQSTLLKKTNIDPTRRYLYLQVLGGKAFLEHLQEPEPLPGQACSTFTLCLHFRNQRFRSKPVPCACEPDFHDGFLLEVHRENLGDGTRMADSTTMLSISDPVHMVLIKTDIFAETTLVASYFLEWRSVLGSENGVTNLTVELMGVGTESKVSVGILNIKLEMYPPLNQTLSQEVVNTQLALERQKTAEKERLFLVYAKQWWREYLQIRPSHNSRLVKIFAQDENGINRPVCSYVKPLRAGRLLDTPRQAARFVNVLGYERAPVIGGGGKQEQWCTLLAFLCRNKGDCEDHANLLCSLLLGYGLEAFVCVGTKAKGVPHAWVMTCGTDGTVTFWDSLTGHRYLHKPINPDEPPAAEQPKPLYPYRTIGCVFNHQTFLGNCQPSDSVETCVFDLNDESKWKPMNEEAVKSVCAPGATTSLPPFPPLCASTIDASVTSNEIEMQLRLLVSEHRKDLGLTTVWEDQLSYLLSPALASYEFERTTSISAGNEEFQDAIRRAVPDGHTFKGFPIHFVYRNARRAFATCLRSPFCEEIICCRGDQVRLAVRVRVFTYPESACAVWIMFACKYRSVL", "length": 640, "header": "tr|E1B8D7-1|E1B8D7_BOVIN Isoform 1 of Centrosomal protein of 76 kDa OS=Bos taurus OX=9913 GN=CEP76 PE=3 SV=2 CANONICAL=E1B8D7-1" }, "locus": { "chromosome": "24", "start_pos": 43071929, "end_pos": 43057927, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013946.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013946.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013946.6", "url": "https://www.ensembl.org/id/ENSBTAP00000013946.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-2565942", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2565942", "resource": "Reactome", "description": "Regulation of PLK1 Activity at G2/M Transition" }, { "id": "R-BTA-380259", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380259", "resource": "Reactome", "description": "Loss of Nlp from mitotic centrosomes" }, { "id": "R-BTA-380270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "resource": "Reactome", "description": "Recruitment of mitotic centrosome proteins and complexes" }, { "id": "R-BTA-380284", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380284", "resource": "Reactome", "description": "Loss of proteins required for interphase microtubule organization from the centrosome" }, { "id": "R-BTA-380320", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "resource": "Reactome", "description": "Recruitment of NuMA to mitotic centrosomes" }, { "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" }, { "id": "R-BTA-8854518", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "resource": "Reactome", "description": "AURKA Activation by TPX2" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "E1B8D7", "url": "https://www.uniprot.org/uniprotkb/E1B8D7" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "E1B8D7", "url": "https://www.uniprot.org/uniprotkb/E1B8D7" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "E1B8D7", "url": "https://www.uniprot.org/uniprotkb/E1B8D7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of centriole replication", "id": "GO:0046599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046599", "evidence": [ { "database": "UniProtKB", "id": "E1B8D7", "url": "https://www.uniprot.org/uniprotkb/E1B8D7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" }, { "start_pos": 238, "end_pos": 240, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8D7" }, { "id": "PF15627", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15627" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CEP76 C2", "eco_id": "ECO_0000259", "start_pos": 81, "end_pos": 238, "start_aa": "Asn", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B8D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8D7" }, { "id": "PF24654", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24654" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CEP76 N-terminal", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 48, "start_aa": "Met", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B8D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8D7" }, { "id": "PF24656", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24656" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CEP76/DRC7 peptidase-like", "eco_id": "ECO_0000259", "start_pos": 342, "end_pos": 472, "start_aa": "Glu", "end_aa": "Met", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B8D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8D7" }, { "id": "PF24652", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24652" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Centrosomal protein of 76 kDa C-terminal", "eco_id": "ECO_0000259", "start_pos": 499, "end_pos": 637, "start_aa": "Thr", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 208, "end_pos": 210 }, { "start_pos": 238, "end_pos": 240 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BB79-1", "uniprot_ac": "E1BB79", "uniprot_id": "E1BB79_BOVIN", "mass": { "chemical_mass": 143144.0, "monoisotopic_mass": 143144.0 }, "refseq": { "ac": "NP_001192770", "name": "tenascin-N precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192770" }, "gene_names": [ { "name": "TNN", "type": "recommended", "evidence": [ { "id": "E1BB79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ] }, { "name": "TNN", "type": "synonym", "evidence": [ { "id": "NP_001192770", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192770" } ] } ], "protein_names": [ { "name": "Tenascin-N", "type": "recommended", "evidence": [ { "id": "E1BB79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB79/entry#names_and_taxonomy" } ] }, { "name": "Tenascin-W", "type": "synonym", "evidence": [ { "id": "E1BB79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB79/entry#names_and_taxonomy" } ] }, { "name": "tenascin-N precursor", "type": "synonym", "evidence": [ { "id": "NP_001192770", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192770" } ] } ], "function": [ { "annotation": "Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1. Involved in neurite outgrowth and cell migration in hippocampal explants. During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells. Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TIS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIS1#function" }, { "database": "UniProtKB", "id": "ARBA00059002", "url": "https://www.uniprot.org/uniprotkb/ARBA00059002#function" }, { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79#function" }, { "database": "UniProtKB", "id": "A0AAA9RYR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYR2#function" }, { "database": "UniProtKB", "id": "A0AAA9SVW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW5#function" }, { "database": "UniProtKB", "id": "A0AAA9TMR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMR8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TNN", "url": "https://www.uniprot.org/uniprotkb/E1BB79", "locus": { "chromosome": "16", "start_pos": 56386531, "end_pos": 56313707, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015650", "url": "https://www.ensembl.org/id/ENSBTAG00000015650" } ] } } ], "crossref": [ { "id": "ENSBTAG00000015650", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015650", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00035", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00035", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00087", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00087", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517433", "url": "https://www.ncbi.nlm.nih.gov/gene/517433", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020837", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020837", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050991", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050991", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517433", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517433", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EAPIDRY", "url": "https://omabrowser.org/oma/group/EAPIDRY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BB79", "url": "https://www.orthodb.org/?gene=E1BB79", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46708", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46708", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46708:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46708:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00147", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00147", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23106", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23106", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3000178", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192770", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RYR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYR2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVW5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIS1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIS1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMR8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB79-1", "url": "https://www.uniprot.org/uniprotkb/E1BB79-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLQGRFCFPLVLLLGSVLLVTSAPATLESSGCSEKEQQVTVSHTYKIDVPKSALVQVEADPQPLRGDGTSLLAPEETEEQNIVFRHNIRLQTPQKDCELAGSVRDLLARVKKLEEEMAEVKERCSAQRCCPGAAGLSRHCSGHGTFSLDTCSCHCEHGWEGADCERLACPGACSGHGRCVDGRCVCEPPYVGADCAYPACPENCSGHGECVRGICQCHEDFISEDCSERRCPGDCSGHGFCDTGECYCEEGFTGLDCAQVVAPQGLQLLKSTEDSLLVSWEPSSQVDHYLLSYYPLGKELSVKQIKVPKEQHRYEILGLLPGTKYIVTLRNVKKDISSSPQHLLATTDLAVPGTAWVTDETENSLDVEWENPLTEVDYYKLQYGPLTGQEVAEVTVPKSGDPKSRYDITGLQPGTEYKITVIPMRGDLEGKPILLNGRTEIDSPTNVVTDRVTEDTVAVSWDPVRAVIDKYMVRYISADGETKDTAVPREQNSTVLTGLRPGEAYEVYVWAERGNQGSKKVDTTALTEIDSPQNLVTEQVTENTATVSWDPVQAVIDRYLVRYISADGDTREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTDIDSPQNLVTEQVTENTATVSWAPVQAVIDRYLVRYTSADGDSGEVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTDIDSPKNLVTEQVTENTATISWDPVQAVIDRYLVRYTSADGDTGEVPVGKEQSSTILTGLRPGVEYTVHVWAQNGDRESRKADTKAPTDIDSPQNLVTKQVTENTATVSWDPVQAVIDRYLVRYTSADGDTREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTEIDSPQNLMTEQVTENTATVSWAPVQAVIDRYLVRYTSADGDTREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTDIDPPQNLHPSAVTQSGGVLTWTPPSAEIDGYILTYQFPDGTVKEVQLGRGDQRFELQGLEQGVTLPVSLVAFKGDRRSRSVSTNLSTVGARFPHPSDCSQVQQNSNAASGLYTIYLHGDASRSLQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRTYVEGFGDPMKEFWLGLDKLHNLTMGTPTRYEVRVDLQTANESAYAVYDSFQVASSKERYRLTVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYKNCHLANPNGRYGETKHSEGVNWEPWKGHEFSIPFVELKIRPHGYSGEHVLSRKKRMLGENSRTF", "length": 1296, "header": "tr|E1BB79-1|E1BB79_BOVIN Isoform 1 of Tenascin-N OS=Bos taurus OX=9913 GN=TNN PE=3 SV=3 CANONICAL=E1BB79-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYR2-1", "url": "https://www.uniprot.org/uniprotkb/E1BB79/entry#A0AAA9RYR2-1", "sequence": { "sequence": "MGLQGRFCFPLVLLLGSVLLVTSAPATLESSGCSEKEQQVTVSHTYKIDVPKSALVQVEADPQPLRGDGTSLLAPEETEEQNIVFRHNIRLQTPQKDCELAGSVRDLLARVKKLEEEMAEVKERCSAQRCCPGAAGLSRHCSGHGTFSLDTCSCHCEHGWEGADCERLACPGACSGHGRCVDGRCVCEPPYVGADCAYPACPENCSGHGECVRGICQCHEDFISEDCSERRCPGDCSGHGFCDTGECYCEEGFTGLDCAQVVAPQGLQLLKSTEDSLLVSWEPSSQVDHYLLSYYPLGKELSVKQIKVPKEQHRYEILGLLPGTKYIVTLRNVKKDISSSPQHLLATTDLAVPGTAWVTDETENSLDVEWENPLTEVDYYKLQYGPLTGQEVAEVTVPKSGDPKSRYDITGLQPGTEYKITVIPMRGDLEGKPILLNGRTEIDSPTNVVTDRVTEDTVAVSWDPVRAVIDKYMVRYISADGETKDTAVPREQNSTVLTGLRPGEAYEVYVWAERGNQGSKKVDTTALTEIDSPQNLVTEQVTENTATVSWDPVQAVIDRYLVRYISADGDTREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTDIDSPQNLVTEQVTENTATVSWAPVQAVIDRYLVRYTSADGDSGEVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTDIDSPKNLVTEQVTENTATISWDPVQAVIDRYLVRYTSADGDTGEVPVGKEQSSTILTGLRPGVEYTVHVWAQNGDRESRKADTKAPTDIDSPQNLVTKQVTENTATVSWDPVQAVIDRYLVRYTSADGDTREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTDIDPPQNLHPSAVTQSGGVLTWTPPSAEIDGYILTYQFPDGTVKEVQLGRGDQRFELQGLEQGVTLPVSLVAFKGDRRSRSVSTNLSTVGARFPHPSDCSQVQQNSNAASGLYTIYLHGDASRSLQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRTYVEGFGDPMKEFWLGLDKLHNLTMGTPTRYEVRVDLQTANESAYAVYDSFQVASSKERYRLTVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYKNCHLANPNGRYGETKHSEGVNWEPWKGHEFSIPFVELKIRPHGYSGEHVLSRKKRMLGENSRTF", "length": 1208, "header": "tr|A0AAA9RYR2-1|E1BB79_BOVIN Computationally mapped isoform of Tenascin-N OS=Bos taurus OX=9913 GN=TNN PE=3 SV=1 CANONICAL=E1BB79-1" }, "locus": { "chromosome": "16", "start_pos": 56385762, "end_pos": 56325447, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126457.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126457.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077760.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077760.1" } ] } }, { "isoform_ac": "A0AAA9SVW5-1", "url": "https://www.uniprot.org/uniprotkb/E1BB79/entry#A0AAA9SVW5-1", "sequence": { "sequence": "MGLQGRFCFPLVLLLGSVLLVTSAPATLESSGCSEKEQQVTVSHTYKIDVPKSALVQVEADPQPLRGDGTSLLAPEETEEQNIVFRHNIRLQTPQKDCELAGSVRDLLARVKKLEEEMAEVKERCSAQRCCPGAAGLSRHCSGHGTFSLDTCSCHCEHGWEGADCERLACPGACSGHGRCVDGRCVCEPPYVGADCAYPACPENCSGHGECVRGICQCHEDFISEDCSERRCPGDCSGHGFCDTGECYCEEGFTGLDCAQVVAPQGLQLLKSTEDSLLVSWEPSSQVDHYLLSYYPLGKELSVKQIKVPKEQHRYEILGLLPGTKYIVTLRNVKKDISSSPQHLLATTDLAVPGTAWVTDETENSLDVEWENPLTEVDYYKLQYGPLTGQEVAEVTVPKSGDPKSRYDITGLQPGTEYKITVIPMRGDLEGKPILLNGRTEIDSPTNVVTDRVTEDTVAVSWDPVRAVIDKYMVRYISADGETKDTAVPREQNSTVLTGLRPGEAYEVYVWAERGNQGSKKVDTTALTEIDSPQNLVTEQVTENTATVSWDPVQAVIDRYLVRYISADGDTREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTEIDSPQNLVTEQVTENTATVSWAPVQAGIDRYLVSYTSADGDTREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTDIDSPKNLVTEQVTENTATISWDPVQAVIDRYLVRYTSADGDTGEVPVGKEQSSTILTGLRPGVEYTVHVWAQNGDRESRKADTKAPTDIDSPQNLVTKQVTENTATVSWDPVQAVIDRYLVRYTSADGDTREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTEIDSPQNLMTEQVTENTATVSWAPVQAVIDRYLVRYTSADGDTREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTDIDPPQNLHPSAVTQSGGVLTWTPPSAEIDGYILTYQFPDGTVKEVQLGRGDQRFELQGLEQGVTLPVSLVAFKGDRRSRSVSTNLSTVGARFPHPSDCSQVQQNSNAASGLYTIYLHGDASRSLQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRTYVEGFGDPMKEFWLGLDKLHNLTMGTPTRYEVRVDLQTANESAYAVYDSFQVASSKERYRLTVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYKNCHLANPNGRYGETKHSEGVNWEPWKGHEFSIPFVELKIRPHGYSGEHVLSRKKRMLGENSRTF", "length": 1296, "header": "tr|A0AAA9SVW5-1|E1BB79_BOVIN Computationally mapped isoform of Tenascin-N OS=Bos taurus OX=9913 GN=TNN PE=3 SV=2 CANONICAL=E1BB79-1" }, "locus": { "chromosome": "16", "start_pos": 56385762, "end_pos": 56325447, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101432.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101432.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094289.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094289.1" } ] } }, { "isoform_ac": "A0AAA9TIS1-1", "url": "https://www.uniprot.org/uniprotkb/E1BB79/entry#A0AAA9TIS1-1", "sequence": { "sequence": "MGLQGRFCFPLVLLLGSVLLVTSAPATLESSGCSEKEQQVTVSHTYKIDVPKSALVQVEADPQPLRGDGTSLLAPEETEEQNIVFRHNIRLQTPQKDCELAGSVRDLLARVKKLEEEMAEVKERCSAQRCCPGAAGLSRHCSGHGTFSLDTCSCHCEHGWEGADCERLACPGACSGHGRCVDGRCVCEPPYVGADCAYPACPENCSGHGECVRGICQCHEDFISEDCSERRCPGDCSGHGFCDTGECYCEEGFTGLDCAQVVAPQGLQLLKSTEDSLLVSWEPSSQVDHYLLSYYPLGKELSVKQIKVPKEQHRYEILGLLPGTKYIVTLRNVKKDISSSPQHLLATTDLAVPGTAWVTDETENSLDVEWENPLTEVDYYKLQYGPLTGQEVAEVTVPKSGDPKSRYDITGLQPGTEYKITVIPMRGDLEGKPILLNGRTEIDSPTNVVTDRVTEDTVAVSWDPVRAVIDKYMVRYISADGETKDTAVPREQNSTVLTGLRPGEAYEVYVWAERGNQGSKKVDTTALTEIDSPQNLVTEQVTENTATVSWDPVQAVIDRYLVRYISADGDTREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTEIDSPQNLVTEQVTENTATVSWAPVQAGIDRYLVSYTSADGDTREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTDIDSPQNLVTEQVTENTATVSWAPVQAVIDRYLVRYTSADGDSGEVPVGKEQSSTILTGLRPGVEYTVHVWAQNGDRESRKADTKAPTDIDSPQNLVTKQVTENTATVSWDPVQAVIDRYLVRYTSADGDTREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTEIDSPQNLMTEQVTENTATVSWAPVQAVIDRYLVRYTSADGDTREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTDIDPPQNLHPSAVTQSGGVLTWTPPSAEIDGYILTYQFPDGTVKEVQLGRGDQRFELQGLEQGVTLPVSLVAFKGDRRSRSVSTNLSTVGARFPHPSDCSQVQQNSNAASGLYTIYLHGDASRSLQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRTYVEGFGDPMKEFWLGLDKLHNLTMGTPTRYEVRVDLQTANESAYAVYDSFQVASSKERYRLTVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYKNCHLANPNGRYGETKHSEGVNWEPWKGHEFSIPFVELKIRPHGYSGEHVLSRKKRMLGENSRTF", "length": 1296, "header": "tr|A0AAA9TIS1-1|E1BB79_BOVIN Computationally mapped isoform of Tenascin-N OS=Bos taurus OX=9913 GN=TNN PE=3 SV=2 CANONICAL=E1BB79-1" }, "locus": { "chromosome": "16", "start_pos": 56385762, "end_pos": 56325447, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104676.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104676.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098356.2", "url": "https://www.ensembl.org/id/ENSBTAP00000098356.2" } ] } }, { "isoform_ac": "A0AAA9TMR8-1", "url": "https://www.uniprot.org/uniprotkb/E1BB79/entry#A0AAA9TMR8-1", "sequence": { "sequence": "MGLQGRFCFPLVLLLGSVLLVTSAPATLESSGCSEKEQQVTVSHTYKIDVPKSALVQVEADPQPLRGDGTSLLAPEETEEQNIVFRHNIRLQTPQKDCELAGSVRDLLARVKKLEEEMAEVKERCSAQRCCPGAAGLSRHCSGHGTFSLDTCSCHCEHGWEGADCERLACPGACSGHGRCVDGRCVCEPPYVGADCAYPACPENCSGHGECVRGICQCHEDFISEDCSERRCPGDCSGHGFCDTGECYCEEGFTGLDCAQVVAPQGLQLLKSTEDSLLVSWEPSSQVDHYLLSYYPLGKELSVKQIKVPKEQHRYEILGLLPGTKYIVTLRNVKKDISSSPQHLLATTDLAVPGTAWVTDETENSLDVEWENPLTEVDYYKLQYGPLTGQEVAEVTVPKSGDPKSRYDITGLQPGTEYKITVIPMRGDLEGKPILLNGRTEIDSPTNVVTDRVTEDTVAVSWDPVRAVIDKYMVRYISADGETKDTAVPREQNSTVLTGLRPGEAYEVYVWAERGNQGSKKVDTTALTDIDSPKNLVTEQVTENTATISWDPVQAVIDRYLVRYTSADGDTGEVPVGKEQSSTILTGLRPGVEYTVHVWAQNGDRESRKADTKAPTDIDSPQNLVTKQVTENTATVSWDPVQAVIDRYLVRYTSADGDTREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTEIDSPQNLMTEQVTENTATVSWAPVQAVIDRYLVRYTSADGDTREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTDIDPPQNLHPSAVTQSGGVLTWTPPSAEIDGYILTYQFPDGTVKEVQLGRGDQRFELQGLEQGVTLPVSLVAFKGDRRSRSVSTNLSTVGARFPHPSDCSQVQQNSNAASGLYTIYLHGDASRSLQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRTYVEGFGDPMKEFWLGLDKLHNLTMGTPTRYEVRVDLQTANESAYAVYDSFQVASSKERYRLTVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYKNCHLANPNGRYGETKHSEGVNWEPWKGHEFSIPFVELKIRPHGYSGEHVLSRKKRMLGENSRTF", "length": 1120, "header": "tr|A0AAA9TMR8-1|E1BB79_BOVIN Computationally mapped isoform of Tenascin-N OS=Bos taurus OX=9913 GN=TNN PE=3 SV=1 CANONICAL=E1BB79-1" }, "locus": { "chromosome": "16", "start_pos": 56385762, "end_pos": 56325447, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096253.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096253.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099809.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099809.1" } ] } }, { "isoform_ac": "E1BB79-1", "url": "https://www.uniprot.org/uniprotkb/E1BB79/entry#E1BB79-1", "sequence": { "sequence": "MGLQGRFCFPLVLLLGSVLLVTSAPATLESSGCSEKEQQVTVSHTYKIDVPKSALVQVEADPQPLRGDGTSLLAPEETEEQNIVFRHNIRLQTPQKDCELAGSVRDLLARVKKLEEEMAEVKERCSAQRCCPGAAGLSRHCSGHGTFSLDTCSCHCEHGWEGADCERLACPGACSGHGRCVDGRCVCEPPYVGADCAYPACPENCSGHGECVRGICQCHEDFISEDCSERRCPGDCSGHGFCDTGECYCEEGFTGLDCAQVVAPQGLQLLKSTEDSLLVSWEPSSQVDHYLLSYYPLGKELSVKQIKVPKEQHRYEILGLLPGTKYIVTLRNVKKDISSSPQHLLATTDLAVPGTAWVTDETENSLDVEWENPLTEVDYYKLQYGPLTGQEVAEVTVPKSGDPKSRYDITGLQPGTEYKITVIPMRGDLEGKPILLNGRTEIDSPTNVVTDRVTEDTVAVSWDPVRAVIDKYMVRYISADGETKDTAVPREQNSTVLTGLRPGEAYEVYVWAERGNQGSKKVDTTALTEIDSPQNLVTEQVTENTATVSWDPVQAVIDRYLVRYISADGDTREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTDIDSPQNLVTEQVTENTATVSWAPVQAVIDRYLVRYTSADGDSGEVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTDIDSPKNLVTEQVTENTATISWDPVQAVIDRYLVRYTSADGDTGEVPVGKEQSSTILTGLRPGVEYTVHVWAQNGDRESRKADTKAPTDIDSPQNLVTKQVTENTATVSWDPVQAVIDRYLVRYTSADGDTREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTEIDSPQNLMTEQVTENTATVSWAPVQAVIDRYLVRYTSADGDTREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTKAPTDIDPPQNLHPSAVTQSGGVLTWTPPSAEIDGYILTYQFPDGTVKEVQLGRGDQRFELQGLEQGVTLPVSLVAFKGDRRSRSVSTNLSTVGARFPHPSDCSQVQQNSNAASGLYTIYLHGDASRSLQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRTYVEGFGDPMKEFWLGLDKLHNLTMGTPTRYEVRVDLQTANESAYAVYDSFQVASSKERYRLTVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYKNCHLANPNGRYGETKHSEGVNWEPWKGHEFSIPFVELKIRPHGYSGEHVLSRKKRMLGENSRTF", "length": 1296, "header": "tr|E1BB79-1|E1BB79_BOVIN Isoform 1 of Tenascin-N OS=Bos taurus OX=9913 GN=TNN PE=3 SV=3 CANONICAL=E1BB79-1" }, "locus": { "chromosome": "16", "start_pos": 56385762, "end_pos": 56325447, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020785.8", "url": "https://www.ensembl.org/id/ENSBTAT00000020785.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020785.6", "url": "https://www.ensembl.org/id/ENSBTAP00000020785.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517433", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517433", "resource": "KEGG Pathway" }, { "id": "R-BTA-3000178", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3000178", "resource": "Reactome", "description": "ECM proteoglycans" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5XVA3-1", "protein_name": "Tenascin-N", "gene_name": "Tnn", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGLWGMLAFPLGFLLASALLVASAPANPETPGCSHKDQQVTVSHTYKIDVPKSALVQVETDPQSLSDDGTSLLVPGEDGEEQNIIFRHNIRLQTPQKNCELADSVQDLLARVKKLEEEMAELKEQCSTSRCCQGAADLSRHCSGHGTFFAETCSCHCDQGWEGADCEQPTCPGACSGHGRCVDGQCVCDQPYVGVDCAYAACPQDCSGHGVCVRGVCQCHKDFTAEDCSEQRCPGDCSGNGFCDTGECYCEMGFTGPDCSQVVAPQGLQLLKSTENSLLVSWEPSSEVDHYLLSYYPLGKEQATKQVRVPKEQHTYDITGLLPGTKYIVTLRNVKKDISSSPQHLLATTDLAVVGTAWVNEETETSLDVEWENPLTEVDYYKLRYGPLTGQEVTEVTVPKSRDPKSRYDITGLQPGTEYKITVVPIRGDLEGKPILLNGRTEIDGPTNVVTNQVTEDTASVSWDPVRADIDKYVVRYISHDGETKEKAVPKDQSSTVLTGLKPGEAYKVFVWAERGNQGSKKADTKALTEIDSPENLVTDRVTENSLSVSWDPVEAEIDRYVVSYTSVDGETKQVPVRKDQSSTVLTGLSPGVEYKVYVWAEKGDRESKKANTKAPTDIDSPKNLVTDQVTENTLSVSWDPVQANIDRYMVSYTSADGETREVPVPKEKSSTVLTGLRPGMEYKVHVWAQKGTQESRKANTKAPTDIDGPKNLVTDQVTETTLSVSWDPVEADIDRYMVRYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGAQDSRKANTKAPTDIDSPKNLVTNQVTENTATISWDPVQADIDRYMVRYTSADGETREVPVRKEKSSTVLTGLRPGVEYTVQVWAQKGARESRKAKTKAPTEIDSPKNLVTNRVTENTATISWDPVRATIDRYMVRYTSADGETKEVPVSKDQSSTILTGLKPGMEYTIHVWAQKGARESKKADTKALTEIDPPKNFRPFGVTHSSGVLTWMPPSAQIDGYILTYQLPNGILKEVELQRGQQRFELQDLEQGVTYPVSLVAFKGNQRSRSVSTTLSTVDARFPHPSDCSQVQQNTNAAASGLYTIYLNGDASRPMQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMKEFWLGLDKLHNLTTGTTTRYEVRADLQTANESAYAVYDFFQVASSKERYKLSVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYKNCHLANPNGKYGETKHSEGVNWEPWKGHEFSIPYVELKIRPFGYSRDRFSGRKKRSIGGKARVF", "length": 1298 }, "evidence": [ { "id": "E1BB79", "url": "https://omabrowser.org/oma/group/E1BB79/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0Y9P7-1", "protein_name": "Tenascin N", "gene_name": "TNN", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDFQSCFAFPIGILLCCALQASAIQLPASENCTSNGQRISFSHSYKIDLPTSSQIKVEADPLQHEGNSGVQLDPGEAEESEEQDIIFRHNIHVHAPKGSCETLAHVKDLLERMEKLEKEVAELREVCSPQKCCGGSQGVTHCSGHGMFLYETCSCKCAEGWEGSDCSRPTCPNLCSGHGRCDGGRCICDEPYFSEDCSQQLCPENCSGNGICDTAKGVCLCYEEFIGEDCSEKRCPGDCSGNGFCDTGECYCHEGFFGPDCSQVLAPQNLQLLNATEDSMAISWDQVTDVDNYLISYYPVGHETLEKQVHVPKEQLSYEITGLRPSTTYNVTLYHVKKGITSEPTHLEASTVPSALSAIWVTEEMEYSLEVEWENPPTNVDYYKLKFRSLVDVDEKQVMVPKSSDPKSRHIMTGLKPGMEYEVTVIPVKDDIEGKPSSVSGRTGIDSPTNVVTGRVTEDTATVSWNKVQAPIDRYMVRYTSADGDTKETEVGSENSIITLLNLKPGMEYTIHIWAEKGPHRSKKASTRALTGIDSPTKLLTDHVTENTITVSWNKVQALIDRYRVNYTSADGDTEEREVEKDENVTTLAGLKPGMEYVIHIWAEKGEQQSKRASTEAVTEIDSPTHLVTDQVTEDTVTISWDRVLALIDRYVVNYTSADGDTEEIEVAKNKTATTLVGLKPGTEYVIYLWAEKGVWQSKRTSTEAVTELDSPKNLVTDQVTEDSATISWDSVRAPIDRYIVSYTSADGGSKEIEVGKAKSTTTLTGLKAGMKYTIHLWAELGSMQSKKASTDALTEIDPPKNLRVSDVTQSTGVLTWTPPTAQIDGYTLTYQGQNGTSKEVQLGPREQQFVLEGLEQGTKYTVFVMAYKGDYQSRKTVGTFSTVSFLYPYPADCAQMQQNGNTSSGTYTIYLNGDGSRPMQVYCDMTTDGGGWIVFQRRSTGELDFYKRWKNYVEGFGDPTGEFWLGLDQLHNLTSSSPSHYELRVDLRTANESAYAVYDFFQVASSRERYRLSVGNYRGNAGDAMTYHNGWMFTTWDRDNDVALSNCALTHHGAWWYKNCHLANLNGKYGESKHSEGVNWEPWKGHEFSIPFTEMKIRPQSSSNESVLARKKRSLPGKRRKIRF", "length": 1125 }, "evidence": [ { "id": "E1BB79", "url": "https://omabrowser.org/oma/group/E1BB79/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1QSR3-1", "protein_name": "Tenascin-N isoform X1", "gene_name": "tnn", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAVRLNRLKRGLFLLGTLFMVSHIVLSEEAVNAEKEVTFSHVYRIDSSCKQGSQVGQLSQDQASEGQLVTVNGENDIVFKHSIRLQPAGCGCADSEDFKALLYRVNGLEEEVNYLKSQCAQGCCKGGAGVDTSCSGHGTYQQDSCSCKCNPGWEGPDCSISSCPDECNDNGRCVDGRCVCYEGYTGHDCSQLTCPNDCKDKGHCVDGKCVCFSGFSGEDCSIATCPNDCIGNGRCVDGQCICDEGFFGIDCSMVLGPKGLRLIKVTDVSLLVEWESVRGAEYYILSYHPKGNKGAIKEVQVENTKNSYLITGLKPGVTYIVQVYAVIRGINSESDQITATTEVSGIEGIKVLSQTEDSIQVDWKNPGIIVDYFKLTHASHDGQGGHENVVMSQEARTKHTIVGLNPGTEYQIGVQAIKGENEGKASFATGVTDIDAPTNLATREVTENSATVTWDGVRAEIDGYMLTYSSAEGTSREIKVAAGATSYQLTSLKPGVLYTVFLWAYKGSRSSRKSMTEAETDIDAPTNLMTREVTEDSASVTWNKVQADIDGYMLKYSSLDGSGQEVRVGADSTSYRFTGLKPGVLYTVYVWAIKGARSSKKSSTEAETDIDAPTNLLTQEVTEDSASVTWNKVQADIDGYMLKYSSLDGSGQEVRVGADSISYRFTGLKPGVLYTVSVWAVKGSRSSRKATTEAETEIDAPKNLKATDVQTQTSTLTWKAPQANIEGYILTYRAEDGSMQTVEKTLTARENRFALSGLEMGKKYIVTLIAYRGSKRSKIVETTFSTVGLAYQFPMDCTQIMRNGNMESGVYTIYVNNNRSRTMQVYCDMKTDGGGWIVFQRRNTGKVDFMKKWRDYMKGFGELTEEFWLGLDKIHELTNTPTQYEARFDLGSGSDRKYAVYDNFKVAPSKQKFKLTIGSYKGNAGDAMTYHQGAPFSTVDSDNDIALGNCALTHQGAWWYKNCHLANLNGRFGDNRHSMGVNWEPWKGHLQSLDFAEIKIRPVGAAGRQKRSLKRRVAAY", "length": 1020 }, "evidence": [ { "id": "E1BB79", "url": "https://omabrowser.org/oma/group/E1BB79/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1S708-1", "protein_name": "Tenascin-N", "gene_name": "TNN", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGLQEMFCFLLALLFGSVLLVASAPATLESPGCSNKEQQVTVSHTYKIDVPKSALVQVEADPQPLSDDGTSLLAPGETEEQNIIFRHNIRLQTPQKDCELAGSVQDLLARVKKLEEEMAEVKEQCSAQRCCPRAAGLSHHCSGHGTFSPVTCSCHCEQGWEGADCERPACPGACSGHGQCVDGRCLCEQPYVGIDCAYPACPENCSGHGACVRGVCQCHEDFTSEDCSERRCPGDCSGHGFCDTGECYCEEGFTGLDCSQVVAPQGLQLLKSTEDSLLVSWEPSSQVDHYLLSYYPLGKERSVKQIQVPKEQHSYEILGLLPGTKYIVTLRNVKKEISSSPQHLLATTDLAVLGTAWVTDETENSLDVEWENPSTEVDYYKLQYGPLTGQEVAEVTVPKSSDPKSRYDITGLQPGTEYKITVVPMRGDLEGKPILLNGRTEIDSPTNVVTDQVTEDTAVVSWDPVRAVIDKYVVRYISADGETKDTAVPKEQSSTVLTGLKPGEAYEVYVWAERGSQESKKADTNALTEIDSPKNLVTDLVTENTATVSWDPVQADIDRYLVRYTSADGDTREVPVGKEKSSTVLTGLRPGVEYTVHVWAQKGDRESGKADTTAPTEIDSPKNLVTNQVTENTATVSWDPVQAVIDRYLVRYTSADGDTREVPVGKEQSSTVLTGLRPGMEYTVHVWAQKGDRESGKADTMAPTDLDSPKNLVTTQVTENTATVSWDPVQAVIDRYLVRYTSADGDTREVPVGKEQSSTILTGLRPGVEYTVHVWAQKGDRESGKADTTAPTDLDSPKNLVTTQVTENTATVSWDPVQAVIDRYLVRYTSADGDTREVPVGKEQSSTILMGLRPGVEYTVHVWAQKGDRESRKADTTAPTDIDSPKNLVTTQVTENTATVSWDPVQAVIDRYLVRYTSADGDTREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESRKADTTAPTDIDSPKNLVTTQVTENTATVSWDPVQAVIDRYLVRYTSADGDTREVPVGKEQSSTVLTGLRPGMEYTVHVWAQKGDRESKKADTMAPTEIDSPQNLVTTRVTENTATVSWDPVQAVIDRYLVRYTSADGDTREVPVGKEQSSTVLMGLRPGVEYTVHVWAQKGDRESRKADTTALTDIDPPQNLRPSSVTQSSGVLTWKPPSAQIDGYILTYQFPDGTVKEVQLGRGDQRFELQGLEQGVTLPVSLVAFKGDRRSRSISTTLSTVGARFPHPSDCSQVQQNSNVASGLYTIYLHGDASRPLQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRTYVEGFGDPMKEFWLGLDKLHNLTTGTPTRYEVRVDLQTANESAFAIYDFFQVASSKERYRLTVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYKNCHLANPNGRYGETKHSEGVNWEPWKGHEFSIPFVELKIRPHGYSGEHVLGRKKRTLGESSRTF", "length": 1472 }, "evidence": [ { "id": "E1BB79", "url": "https://omabrowser.org/oma/group/E1BB79/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q80Z71-1", "protein_name": "Tenascin-N", "gene_name": "Tnn", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLWGMLAFPLGFLLASVLLVASAPATPESPGCSNKEQQVTVSHTYKIDVPKSALVQVETDPQSLSDDGTSLLAPGEDGEEQNIIFRHNIRLQTPQKNCDLADSVQDLLARMKKLEEEMAELKEQCNTNRCCQGAADLSRHCSGHGTFLPETCSCHCDQGWEGADCDQPTCPGACNGHGRCVDGQCVCDAPYVGVDCAYAACPQDCSGHGVCVQGVCQCHEDFTAEDCSEQRCPGDCSGNGFCDTGECYCEMGFTGPDCSQVVAPQGLQLLKSTENSLLVSWEPSSEVDYYLLSYYPLGKEQATKQVRVPKEQHTYDITGLLPGTKYIVTLRNVKKDISSSPQHLLATTDLAVVGTAWVNEETETSLDVEWENPLTEVDYYKLRYGPLTGQEVTEVTVPKSRDPKSRYDITGLQPGTEYKITVVPIRGDLEGKPILLNGRTEIDGPTNVVTNQVTEDTASVSWDPVRADIDKYVVRYIAPDGETKEKAVPKDQSSTVLTGLKPGEAYKVFVWAERGNQGSKKADTKALTEIDSPENLVTDRVTENSLSVSWDPVEADIDRYVVSYTSVDGETKQVPVKKDQRSTVLTGLSPGVEYKVYVWAEKGDRESKKANTKAPTDIDSPKNLVTDQVTENTLSVSWDPVQANIDRYMVSYTSADGETREVPVPKEKSSTVLTGLRPGVEYKVHVWAQKGTQESRKANTKAPTDIDGPKNLVTDQVTETTLSVSWDPVEADIDRYMVRYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGAQDSRKANTKAPTDIDSPKNLVTEQVTESTATVSWDPVEADIDRYVVRYTSVDGETREFLVGKDQTSTVLTGMRPGVEYQVDVWAQKGTQESRKTSTKAPTDIDGPKNLVTDQVTETTLSVSWDPVEADIDRYMVRYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGAQDSRKANTKAPTDIDSPKNLAIDQVTETTLSVSWDPVQADIDRYVVRYTSADGESKEFLIGKEQRSTVLTGLRPGVEYKVEVWAQKGARESKKANTEGHTDIDSPKNLVTNQVTENTATISWDPVQADIDRYMVRYTSADGETREIPVRKEKSSTVLTGLRPGVEYTVQVWAQKGARESKKAKTKAPTEIDSPKNLVTNRVTENTATISWDPVRANIDRYMVRYTSADGETKEIPVSKDQSSTILTGLKPGMEYTIHVWAQKGARESKKADTKALTEIDPPRNLRPFGVTHSGGVLTWLPPSAQIDGYILTYQFPNGTVKEVELPRGQQRFELQDLEQGVTYPVSLVAFKGNQRSRTVSTTLSTVDARFPHPSDCSQVQQNTNAASGLYTIYLNGDASRPMQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMKEFWLGLDKLHNLTTGTTTRYEVRADLQTFNESAYAVYDFFQVASSKERYKLSVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYKNCHLANPNGKYGETKHSEGVNWEPWKGHEFSIPYVELKIRPFGYSRDRFSGRKKRSIGKARMF", "length": 1560 }, "evidence": [ { "id": "E1BB79", "url": "https://omabrowser.org/oma/group/E1BB79/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UQP3-1", "protein_name": "Tenascin-N", "gene_name": "TNN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLQEMFRFPMGLLLGSVLLVASAPATLEPPGCSNKEQQVTVSHTYKIDVPKSALVQVDADPQPLSDDGASLLALGEAREEQNIIFRHNIRLQTPQKDCELAGSVQDLLARVKKLEEEMVEMKEQCSAQRCCQGVTDLSRHCSGHGTFSLETCSCHCEEGREGPACERLACPGACSGHGRCVDGRCLCHEPYVGADCGYPACPENCSGHGECVRGVCQCHEDFMSEDCSEKRCPGDCSGHGFCDTGECYCEEGFTGLDCAQVVTPQGLQLLKNTEDSLLVSWEPSSQVDHYLLSYYPLGKELSGKQIQVPKEQHSYEILGLLPGTKYIVTLRNVKNEVSSSPQHLLATTDLAVLGTAWVTDETENSLDVEWENPSTEVDYYKLRYGPMTGQEVAEVTVPKSSDPKSRYDITGLHPGTEYKITVVPMRGELEGKPILLNGRTEIDSPTNVVTDRVTEDTATVSWDPVQAVIDKYVVRYTSADGDTKEMAVHKDESSTVLTGLKPGEAYKVYVWAERGNQGSKKADTNALTEIDSPANLVTDRVTENTATISWDPVQATIDKYVVRYTSADDQETREVLVGKEQSSTVLTGLRPGVEYTVHVWAQKGDRESKKADTNAPTDIDSPKNLVTDRVTENMATVSWDPVQAAIDKYVVRYTSAGGETREVPVGKEQSSTVLTGLRPGMEYMVHVWAQKGDQESKKADTKAQTDIDSPQNLVTDRVTENMATVSWDPVRATIDRYVVRYTSAKDGETREVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGAQESKKADTKAQTDIDSPQNLVTDWVTENTATVSWDPVQATIDRYVVHYTSANGETREVPVGKEQSSTVLTGLRPGMEYTVHVWAQKGNQESKKADTKAQTEIDGPKNLVTDWVTENMATVSWDPVQATIDKYMVRYTSADGETREVPVGKEHSSTVLTGLRPGMEYMVHVWAQKGAQESKKADTKAQTELDPPRNLRPSAVTQSGGILTWTPPSAQIHGYILTYQFPDGTVKEMQLGREDQRFALQGLEQGATYPVSLVAFKGGRRSRNVSTTLSTVGARFPHPSDCSQVQQNSNAASGLYTIYLHGDASRPLQVYCDMETDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMKEFWLGLDKLHNLTTGTPARYEVRVDLQTANESAYAIYDFFQVASSKERYKLTVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYKNCHLANPNGRYGETKHSEGVNWEPWKGHEFSIPYVELKIRPHGYSREPVLGRKKRTLRGRLRTF", "length": 1299 }, "evidence": [ { "id": "E1BB79", "url": "https://omabrowser.org/oma/group/E1BB79/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "regulation of cell adhesion", "id": "GO:0030155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030155", "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "pmid": "" }, { "name": "regulation of cell migration", "id": "GO:0030334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030334", "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "pmid": "" }, { "name": "regulation of multicellular organismal development", "id": "GO:2000026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000026", "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "pmid": "" }, { "name": "positive regulation of sprouting angiogenesis", "id": "GO:1903672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903672", "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "pmid": "" }, { "name": "regulation of bone development", "id": "GO:1903010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903010", "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "pmid": "" }, { "name": "positive regulation of neuron projection development", "id": "GO:0010976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010976", "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "pmid": "" }, { "name": "osteoblast development", "id": "GO:0002076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002076", "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "pmid": "" }, { "name": "regulation of smooth muscle tissue development", "id": "GO:1905899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905899", "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "pmid": "" }, { "name": "cell-matrix adhesion", "id": "GO:0007160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "pmid": "" }, { "name": "neuron projection extension", "id": "GO:1990138", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990138", "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "tenascin complex", "id": "GO:0090733", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090733", "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "pmid": "" }, { "name": "hippocampal mossy fiber expansion", "id": "GO:1990026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990026", "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "pmid": "" }, { "name": "CA3 pyramidal cell dendrite", "id": "GO:0097442", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097442", "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "integrin binding", "id": "GO:0005178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005178", "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BB79", "url": "https://www.uniprot.org/uniprotkb/E1BB79" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1053, "end_pos": 1055, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1146, "end_pos": 1148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1165, "end_pos": 1167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 493, "end_pos": 495, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BB79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB79" }, { "id": "PS51406", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51406" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibrinogen C-terminal", "eco_id": "ECO_0000259", "start_pos": 1058, "end_pos": 1275, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BB79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB79" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 263, "end_pos": 354, "start_aa": "Ala", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1053, "end_pos": 1055 }, { "start_pos": 1146, "end_pos": 1148 }, { "start_pos": 1165, "end_pos": 1167 }, { "start_pos": 204, "end_pos": 206 }, { "start_pos": 493, "end_pos": 495 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BAU6-1", "uniprot_ac": "E1BAU6", "uniprot_id": "E1BAU6_BOVIN", "mass": { "chemical_mass": 71950.0, "monoisotopic_mass": 71950.0 }, "refseq": { "ac": "NP_001179019", "name": "phosphatidylinositol polyphosphate 5-phosphatase type IV", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179019" }, "gene_names": [ { "name": "INPP5E", "type": "recommended", "evidence": [ { "id": "E1BAU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAU6" } ] }, { "name": "INPP5E", "type": "synonym", "evidence": [ { "id": "NP_001179019", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179019" } ] } ], "protein_names": [ { "name": "Phosphatidylinositol polyphosphate 5-phosphatase type IV", "type": "recommended", "evidence": [ { "id": "E1BAU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAU6/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.36", "type": "synonym", "evidence": [ { "id": "E1BAU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAU6/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.86", "type": "synonym", "evidence": [ { "id": "E1BAU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAU6/entry#names_and_taxonomy" } ] }, { "name": "72 kDa inositol polyphosphate 5-phosphatase", "type": "synonym", "evidence": [ { "id": "E1BAU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAU6/entry#names_and_taxonomy" } ] }, { "name": "Inositol polyphosphate-5-phosphatase E", "type": "synonym", "evidence": [ { "id": "E1BAU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAU6/entry#names_and_taxonomy" } ] }, { "name": "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase", "type": "synonym", "evidence": [ { "id": "E1BAU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAU6/entry#names_and_taxonomy" } ] }, { "name": "Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase", "type": "synonym", "evidence": [ { "id": "E1BAU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAU6/entry#names_and_taxonomy" } ] }, { "name": "inositol polyphosphate-5-phosphatase, 72 kDa", "type": "synonym", "evidence": [ { "id": "NP_001179019", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179019" } ] }, { "name": "peptidase (mitochondrial processing) alpha", "type": "synonym", "evidence": [ { "id": "NP_001179019", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179019" } ] }, { "name": "phosphatidylinositol polyphosphate 5-phosphatase type IV", "type": "synonym", "evidence": [ { "id": "NP_001179019", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179019" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAU6", "url": "https://www.uniprot.org/uniprotkb/E1BAU6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "INPP5E", "url": "https://www.uniprot.org/uniprotkb/E1BAU6", "locus": { "chromosome": "11", "start_pos": 103876001, "end_pos": 103885156, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001354", "url": "https://www.ensembl.org/id/ENSBTAG00000001354" } ] } } ], "crossref": [ { "id": "E1BAU6", "url": "https://alphafold.ebi.ac.uk/entry/E1BAU6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001354", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001354", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09095", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09095", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506349", "url": "https://www.ncbi.nlm.nih.gov/gene/506349", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000300", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000300", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036691", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506349", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506349", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HADYKLR", "url": "https://omabrowser.org/oma/group/HADYKLR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAU6", "url": "https://www.orthodb.org/?gene=E1BAU6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46625", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46625", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46625:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46625:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF22669", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22669", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1660514", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660514", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5624958", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5624958", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179019", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "22764", "url": "https://www.rhea-db.org/rhea/22764", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "25528", "url": "https://www.rhea-db.org/rhea/25528", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "32955", "url": "https://www.rhea-db.org/rhea/32955", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S0D7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0D7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0D7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0D7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAU6", "url": "https://www.uniprot.org/uniprotkb/E1BAU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAU6-1", "url": "https://www.uniprot.org/uniprotkb/E1BAU6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSKLVSLGHSETASQQPTAQGCLCPEGSMLKGLLPNSDEEPVPCLGSPAAGGRQGPERSPELPLDTPEQVSNEDPRAQARPFTPKPPPPRPRLERALSLDEKGWRKRRFRTSREDLTVRNGASPSGGSLQDEVPGTPARSGSPPCLSASLQEIPTARRAPGSGGPSSWGNCLSGMISTSLDLLHREGASAGSTPRLASLLSPRPLPAMARNMASEGLRTANKVDPDHADYKLRLQARLFRAHSSLGPGRPPSPLAYDDCSLHSSRSTFSLLAPIRAKDVRSRSYLEGSLLATGALMGADELARYFPDRSVALFVATWNMQGQKELPPNLDELLLPAEADLAQDLYVVGVQEGCSDRREWEARLQETLGPHYVMLYSAAHGALYMAVLIRRDLIWFCSEVESSTVTTRIVSQIKTKGALGVSFTFFGTSLLFITSHFTSGDGKVGERLVDYSKTVQGLALPKNVPDTSPYRSDAADVTTRFDEVFWFGDFNFRLSGGRAAVEAILKQDLSSSVQALLQHDQLTREMQRGSIFKGFQEPDIHFLPSYKFDVGKDSYDTTSKQRTPSYTDRILYRSRHQGDICPVKYSSCPGVRTSDHRPVYGLFRVKVRPGRDNIPLAAGKFDRDLYLLGIKRRISREIQRQQALKSQHASAICTVS", "length": 656, "header": "tr|E1BAU6-1|E1BAU6_BOVIN Isoform 1 of Phosphatidylinositol polyphosphate 5-phosphatase type IV OS=Bos taurus OX=9913 GN=INPP5E PE=4 SV=1 CANONICAL=E1BAU6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S0D7-1", "url": "https://www.uniprot.org/uniprotkb/E1BAU6/entry#A0AAA9S0D7-1", "sequence": { "sequence": "MPSKLVSLGHSETASQQPTAQGCLCPEGSMLKGLLPNSDEEPVPCLGSPAAGGRQGPERSPELPLDTPEQVSNEDPRAQARPFTPKPPPPRPRLERALSLDEKGWRKRRFRTSREDLTVRNGASPSGGSLQDEVPGTPARSGSPPCLSASLQEIPTARRAPGSGGPSSWGNCLSGMISTSLDLLHREGASAGSTPRLASLLSPRPLPAMARNMASEGLRTANKVDPDHADYKLRLQARLFRAHSSLGPGRPPSPLAYDDCSLHSSRSTFSLLAPIRAKDVRSRSYLEGSLLATGALMGADELARYFPDRSVALFVATWNMQGQKELPPNLDELLLPAEADLAQDLYVVGVQEGCSDRREWEARLQETLGPHYVMLYSAAHGALYMAVLIRRDLIWFCSEVESSTVTTRIVSQIKTKGALGVSFTFFGTSLLFITSHFTSGDGKVGERLVDYSKTVQGLALPKNVPDTSPYRSDAADVTTRFDEVFWFGDFNFRLSGGRAAVEAILKQDLSSSVQALLQHDQLTREMQRGSIFKGFQEPDIHFLPSYKFDVGKDSYDTTSKQRTPSYTVTARGWGAGSGLLGASVCGDSAGGQSRPAQPATNRPRDCPQDRILYRSRHQGDICPVKYSSCPGVRTSDHRPVYGLFRVKVRPGRDNIPLAAGKFDRDLYLLGIKRRISREIQRQQALKSQHASAICTVS", "length": 697, "header": "tr|A0AAA9S0D7-1|E1BAU6_BOVIN Computationally mapped isoform of Phosphatidylinositol polyphosphate 5-phosphatase type IV OS=Bos taurus OX=9913 GN=INPP5E PE=4 SV=1 CANONICAL=E1BAU6-1" }, "locus": { "chromosome": "11", "start_pos": 103884957, "end_pos": 103877005, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125540.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125540.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076789.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076789.1" } ] } }, { "isoform_ac": "E1BAU6-1", "url": "https://www.uniprot.org/uniprotkb/E1BAU6/entry#E1BAU6-1", "sequence": { "sequence": "MPSKLVSLGHSETASQQPTAQGCLCPEGSMLKGLLPNSDEEPVPCLGSPAAGGRQGPERSPELPLDTPEQVSNEDPRAQARPFTPKPPPPRPRLERALSLDEKGWRKRRFRTSREDLTVRNGASPSGGSLQDEVPGTPARSGSPPCLSASLQEIPTARRAPGSGGPSSWGNCLSGMISTSLDLLHREGASAGSTPRLASLLSPRPLPAMARNMASEGLRTANKVDPDHADYKLRLQARLFRAHSSLGPGRPPSPLAYDDCSLHSSRSTFSLLAPIRAKDVRSRSYLEGSLLATGALMGADELARYFPDRSVALFVATWNMQGQKELPPNLDELLLPAEADLAQDLYVVGVQEGCSDRREWEARLQETLGPHYVMLYSAAHGALYMAVLIRRDLIWFCSEVESSTVTTRIVSQIKTKGALGVSFTFFGTSLLFITSHFTSGDGKVGERLVDYSKTVQGLALPKNVPDTSPYRSDAADVTTRFDEVFWFGDFNFRLSGGRAAVEAILKQDLSSSVQALLQHDQLTREMQRGSIFKGFQEPDIHFLPSYKFDVGKDSYDTTSKQRTPSYTDRILYRSRHQGDICPVKYSSCPGVRTSDHRPVYGLFRVKVRPGRDNIPLAAGKFDRDLYLLGIKRRISREIQRQQALKSQHASAICTVS", "length": 656, "header": "tr|E1BAU6-1|E1BAU6_BOVIN Isoform 1 of Phosphatidylinositol polyphosphate 5-phosphatase type IV OS=Bos taurus OX=9913 GN=INPP5E PE=4 SV=1 CANONICAL=E1BAU6-1" }, "locus": { "chromosome": "11", "start_pos": 103884957, "end_pos": 103877005, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001784.6", "url": "https://www.ensembl.org/id/ENSBTAT00000001784.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001784.4", "url": "https://www.ensembl.org/id/ENSBTAP00000001784.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:506349", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506349", "resource": "KEGG Pathway" }, { "id": "R-BTA-1660514", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660514", "resource": "Reactome", "description": "Synthesis of PIPs at the Golgi membrane" }, { "id": "R-BTA-5624958", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5624958", "resource": "Reactome", "description": "ARL13B-mediated ciliary trafficking of INPP5E" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AEE9-1", "protein_name": "Phosphatidylinositol polyphosphate 5-phosphatase type IV", "gene_name": "INPP5E", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPSKWASRGHSEVAPQQPITAQEPEGRMLKGQLPNTDEELAPRPGSPAPPTAPRLGPEKSPVLPLDTAAPVSSKEDDPQAKARPFTPKPPTRPRLERALSLDEKSWRKRRFRTSREDLAARNGASPSGGSLPDKAPETPAHGGSPPCLSTSLQEIPTARGALGGGGPSTWGSCLSGMISTSLDLLHRDGAAARSSPRLASVLPARPLPAMDHSVASESLRTAHKVDADHADYKLRLQARLFRAHSSLGPGRPPSPLACDDGSLHSARSTFSLLAPIRAQDVRSRSYLEGSLLASGALMGADELARYFPDRTVALFVATWNMQGQKELPPNLDELLLPAEADYAQDLYVVGVQEGCSDRREWETRLQETLGPHYVMLHSAAHGALYLSVLIRRDLIWFCSEVESATVTTRIVSQIKTKGALGVSFTFFGTSFLFITSHFTSGDGKVGERLTDYSKTIQGLALPRTVPDTSPYRSDAADVTTRFDGVFWFGDFNFRLSGGRAAVEAMLKREAGASVQALLQHDQLAREMSRGSVFKGFQEPDIHFLPSYKFDVGKDSYDTTSKQRVPSYTDRVLYRSRHRDDICPLKYSCCPGIRTSDHRPVYGLFRVKVRPGRDNIPLAAGKFDRELYLLGIKRRISKETQRQQALKSQHASAICTVS", "length": 657 }, "evidence": [ { "id": "E1BAU6", "url": "https://omabrowser.org/oma/group/E1BAU6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V1AF93-1", "protein_name": "Inositol polyphosphate-5-phosphatase E", "gene_name": "INPP5E", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSSLNGFSQHSGTCVTQRAEGGAVQDLQAKKAGKAAKKETSGNGVLTFESPPRVDTLLNETLKLLPDELKANVKVKSITPRPPRKPRLERAASLDEKNWKRWRRFRTSQESLTDPNETSSSNGSLQEAALTSPIRGRATPCSQCCEPNSLHSSPDASEESPVGKSKGSTSDLGKRASEISSAFGGLLRGKAFAGSKPRLSQIMPARPLPPMELNVASHTLRTANKIDPDLMDYRHYSQHKFGRVSNSLSDTRLHGNGIVYDNCSTDSMKSTFSLLTPIRSKDVRSRSYLEGSLLASGALLGAEELSRCFPDRNVGIFVATWNMQGQKELPENLDDFLLPTDPDYAQDMYVIGVQEGCPDSCCSLLQKRVGNPPPGDAGPPLRHALLCCARSALHVSLHSKGPDLVLLRCVVQYELENGEVKGLLLPEVEYATVTTRIVSQIKTKGALGICFTFFGTSFLFITSHFTSGDSKVNERKLDYNKTIQALTLPKVVPDTNPYRSSSGDVTTRFDEVFWFGDFNFRLNKDRETVDSILNQNPETGVSKLLAYDQLTSEMGRGSIFKGFQEADIHFRPSYKFDIGKDSYDTTSKQRTPSYTDRVVFRSRYRDDIQAVKYSSCPVIKTSDHRPVFALFRVKVRPGRDNIPLAAGQFDRELYLIGIKRRITRELQNRRQQKDQKSSSICSIS", "length": 684 }, "evidence": [ { "id": "E1BAU6", "url": "https://omabrowser.org/oma/group/E1BAU6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9JII1-1", "protein_name": "Phosphatidylinositol polyphosphate 5-phosphatase type IV", "gene_name": "Inpp5e", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPSKSACLRHTEAPGQLEGRMLQGQPPNTEKKLIPTPGFLPASDSQGSETNPMPPFSIPAKTSNQNPQTKANLITPQPPIRPKLERTLSLDDKGWRRRRFRGSQEDLTVQNGASPCRGSLQDSVAQSPAYSRPLPCLSTSLQEIPKSRRATGSEGGSPSLWSDCLSGMISTSLDLLHRDAASGGPPSRLASLHASHTPPAMDLSIASSSLRTANKVDPEHTDYKLRMQTRLVRAHSNLGPSRPRSPLAGDDHSIHSARSFSLLAPIRTKDIRSRSYLEGSLLASGALLGAEELARYFPDRNMALFVATWNMQGQKELPASLDEFLLPTEADYTQDLYVIGIQEGCSDRREWETRLQETLGPQYVLLSSAAHGVLYMSLFIRRDLIWFCSEVEYSTVTTRIVSQIKTKGALGVSFTFFGTSFLFITSHFTSGDGKVAERLLDYSRTIQALALPRNVPDTNPYRSSAGDVTTRFDEVFWFGDFNFRLSGGRVAVEAFLKQKPEVDVLALLQHDQLTREMKKGSIFRGFEEAEIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYKSRHKGDICPMKYSSCPGIKTSDHRPVYGLFQVKVRPGRDNIPLAAGKFDRELYLIGIKRRISKEIQRQEALKSQSSSAVCTVS", "length": 647 }, "evidence": [ { "id": "E1BAU6", "url": "https://omabrowser.org/oma/group/E1BAU6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NRR6-1", "protein_name": "Phosphatidylinositol polyphosphate 5-phosphatase type IV", "gene_name": "INPP5E", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPSKAENLRPSEPAPQPPEGRTLQGQLPGAPPAQRAGSPPDAPGSESPALACSTPATPSGEDPPARAAPIAPRPPARPRLERALSLDDKGWRRRRFRGSQEDLEARNGTSPSRGSVQSEGPGAPAHSCSPPCLSTSLQEIPKSRGVLSSERGSPSSGGNPLSGVASSSPNLPHRDAAVAGSSPRLPSLLPPRPPPALSLDIASDSLRTANKVDSDLADYKLRAQPLLVRAHSSLGPGRPRSPLACDDCSLRSAKSSFSLLAPIRSKDVRSRSYLEGSLLASGALLGADELARYFPDRNVALFVATWNMQGQKELPPSLDEFLLPAEADYAQDLYVIGVQEGCSDRREWETRLQETLGPHYVLLSSAAHGVLYMSLFIRRDLIWFCSEVECSTVTTRIVSQIKTKGALGISFTFFGTSFLFITSHFTSGDGKVAERLLDYTRTVQALVLPRNVPDTNPYRSSAADVTTRFDEVFWFGDFNFRLSGGRTVVDALLCQGLVVDVPALLQHDQLIREMRKGSIFKGFQEPDIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYRSRHKGDICPVSYSSCPGIKTSDHRPVYGLFRVKVRPGRDNIPLAAGKFDRELYLLGIKRRISKEIQRQQALQSQNSSTICSVS", "length": 644 }, "evidence": [ { "id": "E1BAU6", "url": "https://omabrowser.org/oma/group/E1BAU6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9WVR1-1", "protein_name": "Phosphatidylinositol polyphosphate 5-phosphatase type IV", "gene_name": "Inpp5e", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPSKSACLRHTEAPGQLEGRMLQGQLSNPEKKLIPTSASLPAADSQSSQTNSMPPLSMPAKPSNQNLQAKANLITPQPPIRPKLERTLSLDDKGWRRRRFRGSQEDLTVQNGASPCRGSLQDSVAQSPAYSRPLPCLSTSLQEIPKPRRATGSEGGSPSLWSDCLSGMISTSLDLLHREAASGGPHSRLASLRATHTPPAMDLNIASSSLRTANKVDPEHTDYKLRMQNRLVRAHSNLGPSRPRSPLAGDDHSIHSARSSFSLLAPIRTKDIRSRSYLEGSLLASGALLGADELARYFPDRNMALFVATWNMQGQKELPASLDEFLLPTEADYTQDLYVIGVQEGCSDRREWETRLQETLGPQYVLLSSAAHGVLYMSLFIRRDLIWFCSEVEYSTVTTRIVSQIKTKGALGVSFTFFGTSFLFITSHFTSGDGKVAERLLDYNRTIQALALPRNVPDTNPYRSSAGDVTTRFDEVFWFGDFNFRLSGGRVAVEAFLKQDPEVDVLALLQHDQLTREMKKGSIFKGFEEAEIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYKSRHKGDICPMKYSSCPGIKTSDHRPVYGLFRVKVRPGRDNIPLAAGKFDRELYLIGIKRRISKEIQRQEALKSQSSSAVCTVS", "length": 648 }, "evidence": [ { "id": "E1BAU6", "url": "https://omabrowser.org/oma/group/E1BAU6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "E1BAU6", "url": "https://www.uniprot.org/uniprotkb/E1BAU6" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BAU6", "url": "https://www.uniprot.org/uniprotkb/E1BAU6" } ], "pmid": "" }, { "name": "Golgi cisterna membrane", "id": "GO:0032580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032580", "evidence": [ { "database": "UniProtKB", "id": "E1BAU6", "url": "https://www.uniprot.org/uniprotkb/E1BAU6" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "E1BAU6", "url": "https://www.uniprot.org/uniprotkb/E1BAU6" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "E1BAU6", "url": "https://www.uniprot.org/uniprotkb/E1BAU6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "phosphatidylinositol dephosphorylation", "id": "GO:0046856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046856", "evidence": [ { "database": "UniProtKB", "id": "E1BAU6", "url": "https://www.uniprot.org/uniprotkb/E1BAU6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity", "id": "GO:0004439", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004439", "evidence": [ { "database": "UniProtKB", "id": "E1BAU6", "url": "https://www.uniprot.org/uniprotkb/E1BAU6" } ], "pmid": "" }, { "name": "inositol-polyphosphate 5-phosphatase activity", "id": "GO:0004445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004445", "evidence": [ { "database": "UniProtKB", "id": "E1BAU6", "url": "https://www.uniprot.org/uniprotkb/E1BAU6" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "id": "GO:0034485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034485", "evidence": [ { "database": "UniProtKB", "id": "E1BAU6", "url": "https://www.uniprot.org/uniprotkb/E1BAU6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "22764", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1MIH5-1", "F1N1U1-1", "O18964-1", "A0A3Q1LUU0-1", "A0AAA9U0Y4-1", "E1BAU6-1", "E1BLB5-1" ], "evidence": [ { "id": "22764", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22764" } ] }, { "id": "25528", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BBJ7-1", "A0AAA9U0Y4-1", "E1B755-1", "E1BAU6-1", "O18964-1" ], "evidence": [ { "id": "25528", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/25528" } ] }, { "id": "32955", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1B755-1", "E1BAU6-1" ], "evidence": [ { "id": "32955", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/32955" } ] }, { "id": "R-BTA-1675824", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi membrane, cytosol", "input_participant_list": [ "R-ALL-1806165" ], "output_participant_list": [], "enzyme_list": [ "E1BAU6-1" ], "evidence": [ { "id": "R-BTA-1675824", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1675824" } ] }, { "id": "R-BTA-5624953", "name": "ARL13B binds INPP5E", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cilium", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BAU6-1" ], "evidence": [ { "id": "R-BTA-5624953", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5624953" } ] }, { "id": "R-BTA-5624954", "name": "INPP5E translocates to the primary cilium", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cilium", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BAU6-1" ], "evidence": [ { "id": "R-BTA-5624954", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5624954" } ] }, { "id": "R-BTA-5624956", "name": "PDE6D binds INPP5E", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BAU6-1" ], "evidence": [ { "id": "R-BTA-5624956", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5624956" } ] }, { "id": "R-BTA-5638012", "name": "PDE6D dissociates from ARL13B:INPP5E", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cilium", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BAU6-1" ], "evidence": [ { "id": "R-BTA-5638012", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5638012" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1806165", "participant_name": "PI(4,5)P2 [Golgi membrane]", "crossref": [ { "id": "58456", "database": "ChEBI", "url": "" }, { "id": "C04637", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LUU0", "gene_name": "INPP5B", "activity": [ { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "A0A3Q1LUU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUU0" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "A0A3Q1LUU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUU0" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "A0A3Q1LUU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUU0" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "A0A3Q1LUU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUU0" } ] } ] }, { "uniprot_ac": "A0A3Q1MIH5", "gene_name": "SYNJ1", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "A0A3Q1MIH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIH5" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "A0A3Q1MIH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIH5" } ] } ] }, { "uniprot_ac": "A0AAA9U0Y4", "gene_name": "OCRL", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0Y4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0Y4" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "A0AAA9U0Y4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0Y4" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0Y4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0Y4" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "A0AAA9U0Y4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0Y4" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "A0AAA9U0Y4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0Y4" } ] }, { "ec_number": "3.1.3.86", "activity": "", "evidence": [ { "id": "A0AAA9U0Y4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0Y4" } ] } ] }, { "uniprot_ac": "E1B755", "gene_name": "PTPRQ", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "E1B755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B755" } ] }, { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "E1B755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B755" } ] }, { "ec_number": "3.1.3.95", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate.", "evidence": [ { "id": "E1B755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B755" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "E1B755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B755" } ] }, { "ec_number": "3.1.3.86", "activity": "", "evidence": [ { "id": "E1B755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B755" } ] }, { "ec_number": "3.1.3.95", "activity": "", "evidence": [ { "id": "E1B755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B755" } ] } ] }, { "uniprot_ac": "E1BAU6", "gene_name": "INPP5E", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "E1BAU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAU6" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "E1BAU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAU6" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "E1BAU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAU6" } ] }, { "ec_number": "3.1.3.86", "activity": "", "evidence": [ { "id": "E1BAU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAU6" } ] } ] }, { "uniprot_ac": "E1BBJ7", "gene_name": "INPPL1", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "E1BBJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBJ7" } ] }, { "ec_number": "3.1.3.86", "activity": "", "evidence": [ { "id": "E1BBJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBJ7" } ] } ] }, { "uniprot_ac": "E1BLB5", "gene_name": "INPP5J", "activity": [ { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "E1BLB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLB5" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "E1BLB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLB5" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "E1BLB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLB5" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "E1BLB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLB5" } ] } ] }, { "uniprot_ac": "F1N1U1", "gene_name": "SYNJ2", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "F1N1U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1U1" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "F1N1U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1U1" } ] } ] }, { "uniprot_ac": "O18964", "gene_name": "SYNJ1", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "O18964", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18964" } ] }, { "ec_number": "3.1.3.95", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate.", "evidence": [ { "id": "O18964", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18964" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "O18964", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18964" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAU6" }, { "id": "SM00128", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00128" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Inositol polyphosphate-related phosphatase", "eco_id": "ECO_0000259", "start_pos": 309, "end_pos": 611, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.86", "ec_name": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "3.1.3.86", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86" }, { "id": "3.1.3.86", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.86" } ] }, { "ec_number": "3.1.3.36", "ec_name": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "3.1.3.36", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36" }, { "id": "3.1.3.36", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.36" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCP2-1", "uniprot_ac": "E1BCP2", "uniprot_id": "E1BCP2_BOVIN", "mass": { "chemical_mass": 31983.0, "monoisotopic_mass": 31983.0 }, "refseq": { "ac": "NP_001179280", "name": "RAD52 motif-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179280" }, "gene_names": [ { "name": "LOC614269", "type": "recommended", "evidence": [ { "id": "E1BCP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCP2" } ] }, { "name": "RDM1", "type": "recommended", "evidence": [ { "id": "E1BCP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCP2" } ] }, { "name": "LOC614269", "type": "synonym", "evidence": [ { "id": "E1BCP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCP2" } ] }, { "name": "RDM1", "type": "synonym", "evidence": [ { "id": "NP_001179280", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179280" } ] } ], "protein_names": [ { "name": "RAD52 motif-containing protein 1", "type": "recommended", "evidence": [ { "id": "E1BCP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCP2/entry#names_and_taxonomy" } ] }, { "name": "RAD52 motif 1", "type": "synonym", "evidence": [ { "id": "NP_001179280", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179280" } ] }, { "name": "RAD52 motif-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001179280", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179280" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCP2", "url": "https://www.uniprot.org/uniprotkb/E1BCP2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RDM1", "url": "https://www.uniprot.org/uniprotkb/E1BCP2", "locus": { "chromosome": "19", "start_pos": 45202473, "end_pos": 45220986, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000030", "url": "https://www.ensembl.org/id/ENSBTAG00000000030" } ] } } ], "crossref": [ { "id": "E1BCP2", "url": "https://alphafold.ebi.ac.uk/entry/E1BCP2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000030", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000030", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000027274", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027274", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12364", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12364", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513486", "url": "https://www.ncbi.nlm.nih.gov/gene/513486", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015753", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015753", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029423", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029423", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034200", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034200", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040224", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040224", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513486", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513486", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PAYECRS", "url": "https://omabrowser.org/oma/group/PAYECRS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCP2", "url": "https://www.orthodb.org/?gene=E1BCP2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23045", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23045", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23045:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23045:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31164", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31164", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31164:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31164:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14914", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14914", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25517", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25517", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179280", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S239", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S239", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S239-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S239-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ20-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T755", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T755", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T755-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T755-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NK07", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NK07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NK07-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NK07-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQ18", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQ18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQ18-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQ18-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NY51", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NY51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NY51-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NY51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCP2", "url": "https://www.uniprot.org/uniprotkb/E1BCP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCP2-1", "url": "https://www.uniprot.org/uniprotkb/E1BCP2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MX69", "url": "https://www.uniprot.org/uniprotkb/G3MX69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MX69-1", "url": "https://www.uniprot.org/uniprotkb/G3MX69-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAELVPFAVPTGSDKTLLVWELSSGPTAEALQHSLFTVFSQFGLLYSVRVFPNAAVAGPGFYAVIKFYSARDAYRAQKACNQKQLFQKSPVKIRLGTQHKAVQHNALALNSSRCQELANYYFGFNGWSKRIIKLQDLSDPEEETENEDMVAPLQRQSLKFFCALEVVLPSYECRSPGVGMAEEPLDNLEEGPLSLLMKRKKTQKLAIQKAMTDAFQKLQIVVLESGKIAVAYRSCEEVTDARTEEELQDLIQVSCFSWKPCGQGEEECLSDLSFEEQEFTVPELD", "length": 285, "header": "tr|E1BCP2-1|E1BCP2_BOVIN Isoform 1 of RAD52 motif-containing protein 1 OS=Bos taurus OX=9913 GN=RDM1 PE=4 SV=2 CANONICAL=E1BCP2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S239-1", "url": "https://www.uniprot.org/uniprotkb/E1BCP2/entry#A0AAA9S239-1", "sequence": { "sequence": "MAELVPFAVPTGSDKTLLVWELSSGPTAEALQHSLFTVFSQFGLLYSVRVFPNAAVAGPGFYAVIKFYSARDAYRAQKACNQKQLFQKSPVKIRLGTQHKAVQHNALALNSSRCQELANYYFGFNGWSKRIIKLQDLSDPEEETENEDMVAPLQRQSLKFFCALEVVLPSYECRSPGVGMAEEPLDNLEEGPLSLLMKRKKTQKLAIQKAMTDAFQKLQIVVLESGKIAVAYRSCEEVTDARTEEELQDLIQFAERKPGFDKDQGLLTLHDSTRPPPPHYPLCTT", "length": 285, "header": "tr|A0AAA9S239-1|E1BCP2_BOVIN Computationally mapped isoform of RAD52 motif-containing protein 1 OS=Bos taurus OX=9913 GN=RDM1 PE=4 SV=1 CANONICAL=E1BCP2-1" }, "locus": { "chromosome": "19", "start_pos": 45220860, "end_pos": 45211220, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135387.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135387.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079963.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079963.1" } ] } }, { "isoform_ac": "A0AAA9SQ20-1", "url": "https://www.uniprot.org/uniprotkb/E1BCP2/entry#A0AAA9SQ20-1", "sequence": { "sequence": "MAELVPFAVPTGSDKTLLVWELSSGPTAEALQHSLFTVFSQFGLLYSVRVFPNAAVAGPGFYAVIKFYSARDAYRAQKACNQKQLFQKSPVKIRLGTQHKAVQHNALALNSSRCQELANYYFGFNGWSKRIIKLQDLSDPEEETENEDMVAPLQRQSLKFFCALEVVLPSYECRSPGVGMAEEPLDNLEEESGKIAVAYRSCEEVTDARTEEELQDLIQVSCFSWKPCGQGEEECLSDLSFEEQEFTVPELD", "length": 252, "header": "tr|A0AAA9SQ20-1|E1BCP2_BOVIN Computationally mapped isoform of RAD52 motif-containing protein 1 OS=Bos taurus OX=9913 GN=RDM1 PE=4 SV=1 CANONICAL=E1BCP2-1" }, "locus": { "chromosome": "19", "start_pos": 45220860, "end_pos": 45210209, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107626.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107626.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088415.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088415.1" } ] } }, { "isoform_ac": "A0AAA9T755-1", "url": "https://www.uniprot.org/uniprotkb/E1BCP2/entry#A0AAA9T755-1", "sequence": { "sequence": "MAELVPFAVPTGSDKTLLVWELSSGPTAEALQHSLFTVFSQFGLLYSVRVFPNAAVAGPGFYAVIKFYSARDAYRAQKACNQKQLFQKSPVKIRLGTQHKAVQHNALALNSSRCQELANYYFGFNGWSKRIIKLQDLSDPEEETENEDMVAPLQRQSLKFFCALEVVLPSYECRSPGVGMAEEPLDNLEEGPLSLLMKRKKTQKLAIQKAMTDAFQKLQIVVLESGKIAVAYRSCEEVTDARTEEELQDLIQKFPRKLYFLH", "length": 262, "header": "tr|A0AAA9T755-1|E1BCP2_BOVIN Computationally mapped isoform of RAD52 motif-containing protein 1 OS=Bos taurus OX=9913 GN=RDM1 PE=4 SV=1 CANONICAL=E1BCP2-1" }, "locus": { "chromosome": "19", "start_pos": 45220860, "end_pos": 45202515, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125334.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125334.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092577.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092577.1" } ] } }, { "isoform_ac": "A0ABI0NK07-1", "url": "https://www.uniprot.org/uniprotkb/E1BCP2/entry#A0ABI0NK07-1", "sequence": { "sequence": "MAELVPFAVPTGSDKTLLVWELSSGPTAEALQHSLFTVFSQFGLLYSVRVFPNAAVAGPGFYAVIKFYSARDAYRAQKACNQKQLFQKSPVKIRLGTQHKAVQHNALALNSSRCQELANYYFGFNGWSKRIIKLQDLSDPEEETENEDMVAPLQRQSLKFFCALEVVLPSYECRSPGVGMAEEPLDNLEEGPLSLLMKRKKTQKLAIQKAMTDAFQKLQIVVLESGKIAVAYRSCEEVTDARTEEELQDLIQADSLECRGPLRSLSCLGF", "length": 270, "header": "tr|A0ABI0NK07-1|A0ABI0NK07_BOVIN Computationally mapped isoform of RAD52 motif-containing protein 1 OS=Bos taurus OX=9913 GN=LOC614269 PE=4 SV=1 CANONICAL=E1BCP2-1" }, "locus": { "chromosome": "19", "start_pos": 45220860, "end_pos": 45211075, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000149447.1", "url": "https://www.ensembl.org/id/ENSBTAT00000149447.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104882.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104882.1" } ] } }, { "isoform_ac": "A0ABI0NQ18-1", "url": "https://www.uniprot.org/uniprotkb/E1BCP2/entry#A0ABI0NQ18-1", "sequence": { "sequence": "MAELVPFAVPTGSDKTLLVWELSSGPTAEALQHSLFTVFSQFGLLYSVRVFPNAAVAGPGFYAVIKFYSARDAYRAQKACNQKQLFQKSPVKIRLGTQHKAVQHNALALNSSRCQELANYYFGFNGWSKRIIKLQDLSDPEEETENEDMVAPLQRQSLKFFCALEVVLPSYECRSPGVGMAEEPLDNLEEGPLSLLMKRKKTQKLAIQKAMTDAFQKLQIVVLGKTFLILLKVLQFQ", "length": 237, "header": "tr|A0ABI0NQ18-1|A0ABI0NQ18_BOVIN Computationally mapped isoform of RAD52 motif-containing protein 1 OS=Bos taurus OX=9913 GN=LOC614269 PE=4 SV=1 CANONICAL=E1BCP2-1" }, "locus": { "chromosome": "19", "start_pos": 45220860, "end_pos": 45215846, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147585.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147585.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105284.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105284.1" } ] } }, { "isoform_ac": "A0ABI0NY51-1", "url": "https://www.uniprot.org/uniprotkb/E1BCP2/entry#A0ABI0NY51-1", "sequence": { "sequence": "MAELVPFAVPTGSDKTLLVWELSSGPTAEALQHSLFTVFSQFGLLYSVRVFPNAAVAGPGFYAVIKFYSARDAYRAQKACNQKQLFQKSPVKIRLGTQHKAVQHNALALNSSRCQELANYYFGFNGWSKRIIKVSCFSWKPCGQGEEECLSDLSFEEQEFTVPELD", "length": 166, "header": "tr|A0ABI0NY51-1|A0ABI0NY51_BOVIN Computationally mapped isoform of RAD52 motif-containing protein 1 OS=Bos taurus OX=9913 GN=LOC614269 PE=4 SV=1 CANONICAL=E1BCP2-1" }, "locus": { "chromosome": "19", "start_pos": 45220860, "end_pos": 45210209, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147743.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147743.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106298.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106298.1" } ] } }, { "isoform_ac": "E1BCP2-1", "url": "https://www.uniprot.org/uniprotkb/E1BCP2/entry#E1BCP2-1", "sequence": { "sequence": "MAELVPFAVPTGSDKTLLVWELSSGPTAEALQHSLFTVFSQFGLLYSVRVFPNAAVAGPGFYAVIKFYSARDAYRAQKACNQKQLFQKSPVKIRLGTQHKAVQHNALALNSSRCQELANYYFGFNGWSKRIIKLQDLSDPEEETENEDMVAPLQRQSLKFFCALEVVLPSYECRSPGVGMAEEPLDNLEEGPLSLLMKRKKTQKLAIQKAMTDAFQKLQIVVLESGKIAVAYRSCEEVTDARTEEELQDLIQVSCFSWKPCGQGEEECLSDLSFEEQEFTVPELD", "length": 285, "header": "tr|E1BCP2-1|E1BCP2_BOVIN Isoform 1 of RAD52 motif-containing protein 1 OS=Bos taurus OX=9913 GN=RDM1 PE=4 SV=2 CANONICAL=E1BCP2-1" }, "locus": { "chromosome": "19", "start_pos": 45220860, "end_pos": 45210209, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000033.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000033.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000033.5", "url": "https://www.ensembl.org/id/ENSBTAP00000000033.5" } ] } }, { "isoform_ac": "G3MX69-1", "url": "https://www.uniprot.org/uniprotkb/E1BCP2/entry#G3MX69-1", "sequence": { "sequence": "MAELVPFAVPTGSDKTLLVWELSSGPTAEALQHSLFTVFSQFGLLYSVRVFPNAAVAGPGFYAVIKFYSARDAYRAQKACNQKQLFQKSPVKIRLGTQHKAVQHNALALNSSRCQELANYYFGFNGWSKRIIKLQDLSDPEEETENEDMVAPLQRQSLKFFCALEVVLPSYECRSPGVGMAEEPLDNLEEGPLSLLMKRKKTQKLAIQKAMTDAFQKLQIVVLEISKETIFLTLMKIYGRHTVGLRNYLSCNKIQSIERRSFEPLPFLQFINLGCNLLTELSFGTFQAWHGMQFLHKLILNRNPLTAVEDSYLFKLPALKYLDMGTTQVSLTTIESILMMTLELEKLILPIRMACCLCQFKNTIEVVCKTVKLHCDSGCLTNVTFCDENTSIGNAEGSFMKVLQARKKNTSTELTIEPERASSDKSAVSLSAFMNEQLDFNDESDVISALNYILPYFSEGNLEDVESTLLPFIQLLFTNAHEGDMPVGHFKNNTKKPSVKPIDNNSTYKNKLRKLYFLENLLDAEIQEKIDEVKKKEKTAMLIHANLLGPKFKRQMFPKKLEKAQPQENSPAEIDSPGQRLLRVNRVLKHPRGLQKRHFKDAGDESSEKKQNAQPLVENTAKERRLRRPSPRELDELDMVQRPRKLVGNSFNTEPSFMKEHKAAVSSFLKQYSRGRPSDPLPPKPQPEAKNKSKDLSYTIFVLEDADARVRNMKSSKPVSHSGKKYIFHKTRSRMPHRTLKAKVSRKLRKKGSLNRMMLARRPLFSAVRSLINSPPREAFSSSGLLDPQENRFSELYSLSNPPKENSSSVNNTPHVSEAVISSGNITRPKETRPGITAQINVSSAHSTVAADFMPPVKHTNETQWEYHNVGIEFASKPPSVSFPVLSSPGDQFESQLNQQLRSLIPNNDVRKLIAHVIRTLKMDCSETHVQLACAKLISRTGLLMKLLSEQQEIKVSKAEWDTDQWKTDNYINESTEAQSEQKEQEPSELAKEVPGYGYNNKLILAISVTVVVMFLIIMFCLIEIYSHRTTSEEEGSRRGFFGFLLHKRSSGTSESQEGFFWRRRPLWLQDMYRPLNATRKKNMAQKLHDKESSEEDEIFNKNAGGAPEAPTEEAPPATDSAAEEPTGEESEAAADTATE", "length": 1140, "header": "tr|G3MX69-1|E1BCP2_BOVIN Computationally mapped isoform of RAD52 motif-containing protein 1 OS=Bos taurus OX=9913 GN=RDM1 PE=4 SV=4 CANONICAL=E1BCP2-1" }, "locus": { "chromosome": "19", "start_pos": 45220860, "end_pos": 45159960, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063914.4", "url": "https://www.ensembl.org/id/ENSBTAT00000063914.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054129.4", "url": "https://www.ensembl.org/id/ENSBTAP00000054129.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 27, "start_aa": "Thr", "end_pos": 27, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr27", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:513486", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513486", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZZZ4-1", "protein_name": "RAD52 motif-containing protein 1", "gene_name": "Rdm1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAELISFVVPTQSDKVLLVWELSAGPPAEALSVRVLAEGEGAGITGAQEPRAPVEGGAQRTGSLRGTLSHRRLSGPKMFSQFGLLYSVRVFPNAAVAGPGFYAIVKFYSSRDAQRAQKACDGKPLFQTSPVKVRLGTRHKALQHQAFALNSSRCQELANYYFGFNGWSKRIVKLQELSGLEDAALAVPMQKRNPQFFCAVEVVLPAYGCTSPGVGISEEPLPQLEEGQPSFLTKRKTAQKLAFQAALSDAFQKLTIVVLESGRIAVEYRPTEEDLDARSEEELQNLIQVGCFPSSQSSQREEECLSDFSLEEEDLKLCGLH", "length": 321 }, "evidence": [ { "id": "E1BCP2", "url": "https://omabrowser.org/oma/group/E1BCP2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8NG50-1", "protein_name": "RAD52 motif-containing protein 1", "gene_name": "RDM1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAELVPFAVPIESDKTLLVWELSSGPTAEALHHSLFTAFSQFGLLYSVRVFPNAAVAHPGFYAVIKFYSARAAHRAQKACDRKQLFQKSPVKVRLGTRHKAVQHQALALNSSKCQELANYYFGFNGCSKRIIKLQELSDLEERENEDSMVPLPKQSLKFFCALEVVLPSCDCRSPGIGLVEEPMDKVEEGPLSFLMKRKTAQKLAIQKALSDAFQKLLIVVLESGKIAVEYRPSEDIVGVRCEEELHGLIQVPCSPWKQYGQEEEGYLSDFSLEEEEFRLPELD", "length": 284 }, "evidence": [ { "id": "E1BCP2", "url": "https://omabrowser.org/oma/group/E1BCP2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CQK3-1", "protein_name": "RAD52 motif-containing protein 1", "gene_name": "Rdm1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAELISFVVPTQSDKVLLVWDLSTGPPAEALSHSLFTVFSQFGLLYSVRVFPNAAVARPGFYAIIKFYSSRDAQRAQKACDGKPLFQTSPVKVRLGTRHKALQHQAFALNSSRCQELANYYFGFSGWSKRIIKLQELSGLEDAALAVPMQKGSPQFLCAVEVVLPPYGCRSPGVGISEEPLRQLEEGQSSFLMKRKTAQKLAFQAAVSDAFQKLTIVVLESGRIAVEYRPTAEDLDARSEEELQNLIQVSCSSWSQSSQREEECLSDFSLEEEDLKLCDPH", "length": 281 }, "evidence": [ { "id": "E1BCP2", "url": "https://omabrowser.org/oma/group/E1BCP2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BCP2", "url": "https://www.uniprot.org/uniprotkb/E1BCP2" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BCP2", "url": "https://www.uniprot.org/uniprotkb/E1BCP2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "E1BCP2", "url": "https://www.uniprot.org/uniprotkb/E1BCP2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BCP2", "url": "https://www.uniprot.org/uniprotkb/E1BCP2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCP2" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 15, "end_pos": 98, "start_aa": "Lys", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 27 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B9Q4-1", "uniprot_ac": "E1B9Q4", "uniprot_id": "E1B9Q4_BOVIN", "mass": { "chemical_mass": 152749.0, "monoisotopic_mass": 152749.0 }, "refseq": {}, "gene_names": [ { "name": "MSH6", "type": "recommended", "evidence": [ { "id": "E1B9Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ] } ], "protein_names": [ { "name": "DNA mismatch repair protein", "type": "recommended", "evidence": [ { "id": "E1B9Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the post-replicative DNA mismatch repair system (MMR).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S313", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S313#function" }, { "database": "UniProtKB", "id": "PIRNR037677", "url": "https://www.uniprot.org/uniprotkb/PIRNR037677#function" }, { "database": "UniProtKB", "id": "RU003756", "url": "https://www.uniprot.org/uniprotkb/RU003756#function" }, { "database": "UniProtKB", "id": "A0AAA9SZP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZP1#function" }, { "database": "UniProtKB", "id": "A0AAA9T6B7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6B7#function" }, { "database": "UniProtKB", "id": "A0AAA9TC26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC26#function" }, { "database": "UniProtKB", "id": "A0AAA9U0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0J2#function" }, { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4#function" }, { "database": "UniProtKB", "id": "A0ABI0P5Y3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5Y3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MSH6", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4", "locus": { "chromosome": "11", "start_pos": 30143448, "end_pos": 30105964, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001424", "url": "https://www.ensembl.org/id/ENSBTAG00000001424" } ] } } ], "crossref": [ { "id": "E1B9Q4", "url": "https://alphafold.ebi.ac.uk/entry/E1B9Q4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001424", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001424", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05837", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05837", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000313", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000313", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000432", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000432", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007695", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007695", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007696", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007696", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007861", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007861", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016151", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016151", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017261", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017261", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036678", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036678", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045076", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045076", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B9Q4", "url": "https://www.orthodb.org/?gene=E1B9Q4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11361", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11361", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11361:SF148", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11361:SF148", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00488", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00488", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01624", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01624", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05188", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05188", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05190", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05190", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05192", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05192", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5358565", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5358565", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S313", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S313", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S313-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S313-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZP1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6B7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6B7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6B7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6B7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC26-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0J2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0J2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0J2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0J2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P5Y3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5Y3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P5Y3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5Y3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9Q4-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRQSTLFSFFPKSPAVNNANKAPVRASSGSSAAAAATGASPSPGGDAAWNEAGPEPLAGTTSRAEARNLNGGLRKSASPAVPASSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSARVHVQFFDDSPTRGWVSRRLLKPYTGSHSKEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEPSEPEEEEETEVGHCATYTSDKSEEENDIESEEEVRPKVQGSRRSSRQIKKRRVISDSESDVGGSDVEFKPDTKEEASSDEISSGVGDSDSEGLDTPVKVAPKRKRMVTGNGSLKRKSSRKEMPSATKRATGISSETKNTLSAFSVPQNSEPQAHISGGCDDSNRPTVWYHETLEWLKEEKRRDVHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQNFDLVIFYKVGKFYEMYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSVLEGDPSENYSKYLLSLKEKEEESSGHTRVYGVCFVDTSLGRFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGNLSMDTKMILKSSLSSSLQEGLIPGSQFWDAAKTLRTLLEEGYFTDKLNEDGGVMLPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYVPLDSDMVHATRPGAVFAKANQRMVLDAVTLNNLEIFLNGTNGSTEGTLLEKIDTCHTPFGKRLLKQWLCAPLCNPHAINDRLDAIEDLMVVPDKISEVVDLLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVICKIIGIMEEVIDDFKSKILKQVLTLQTKSPEGRFPDLTSELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRSRIGCRTIVYWGIGRNRYQLEIPENFITRNLPEEYELKSTKKGCKRYWTKTIEKKLGNLINAEERRDASLKDCMRRLFYNFDKNYKDWQAAVECIAVLDVLLCLTNYSRGGDGPMCRPIILLPEEDTPPFLDLKGSRHPCITKTFFGDDFIPNDILIGCEEEEEENGKAYCVLVTGPNMGGKSTLMRQAGLLAIMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILTHATAHSLVLVDELGRGTATFDGTAIANAVVKELAENIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFEKMTQSLRLFREVCLASERSTVDADAVHKLLTLIEEL", "length": 1362, "header": "tr|E1B9Q4-1|E1B9Q4_BOVIN Isoform 1 of DNA mismatch repair protein OS=Bos taurus OX=9913 GN=MSH6 PE=3 SV=4 CANONICAL=E1B9Q4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S313-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4/entry#A0AAA9S313-1", "sequence": { "sequence": "MRSLWRGGCVGSWGGSSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSARVHVQFFDDSPTRGWVSRRLLKPYTGSHSKEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEPSEPEEEEETEVGATYTSDKSEEENDIESEEEVRPKVQGSRRSSRQIKKRRVISDSESDVGGSDVEFKPDTKEEASSDEISSGVGDSDSEGLDTPVKVAPKRKRMVTGNGSLKRKSSRKEMPSATKRATGISSETKNTLSAFSVPQNSEPQAHISGGCDDSNRPTVWYHETLEWLKEEKRRDVHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQNFDLVIFYKVGKFYEMYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSVLEGDPSENYSKYLLSLKEKEEESSGHTRVYGVCFVDTSLGRFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGNLSMDTKMILKSSLSSSLQEGLIPGSQFWDAAKTLRTLLEEGYFTDKLNEDGGVMLPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYVPLDSDMVHATRPGAVFAKANQRMVLDAVTLNNLEIFLNGTNGSTEGTLLEKIDTCHTPFGKRLLKQWLCAPLCNPHAINDRLDAIEDLMVVPDKISEVVDLLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVICKIIGIMEEVIDDFKSKILKQVLTLQTKSPEGRFPDLTSELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRSRIGCRTIVYWGIGRNRYQLEIPENFITRNLPEEYELKSTKKGCKRYWTKTIEKKLGNLINAEERRDASLKDCMRRLFYNFDKNYKDWQAAVECIAVLDVLLCLTNYSRGGDGPMCRPIILLPEEDTPPFLDLKGSRHPCITKTFFGDDFIPNDILIGCEEEEEENGKAYCVLVTGPNMGGKSTLMRQAGLLAIMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILTHATAHSLVLVDELGRGTATFDGTAIANAVVKELAENIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFEKMTQSLRLFREVCLASERSTVDADAVHKLLTLIEEL", "length": 1291, "header": "tr|A0AAA9S313-1|E1B9Q4_BOVIN Computationally mapped isoform of DNA mismatch repair protein OS=Bos taurus OX=9913 GN=MSH6 PE=3 SV=1 CANONICAL=E1B9Q4-1" }, "locus": { "chromosome": "11", "start_pos": 30143364, "end_pos": 30122959, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122211.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122211.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076492.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076492.1" } ] } }, { "isoform_ac": "A0AAA9SZP1-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4/entry#A0AAA9SZP1-1", "sequence": { "sequence": "MSRQSTLFSFFPKSPAVNNANKAPVRASSGSSAAAAATGASPSPGGDAAWNEAGPEPLAGTTSRAEARNLNGGLRKSASPAVPASSSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSARVHVQFFDDSPTRGWVSRRLLKPYTGSHSKEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEPSEPEEEEETEVKLKLLSIEKENSLFLKVGATYTSDKSEEENDIESEEEVRPKVQGSRRSSRQIKKRRVISDSESDVGGSDVEFKPDTKEEASSDEISSGVGDSDSEGLDTPVKVAPKRKRMVTGNGSLKRKSSRKEMPSATKRATGISSETKNTLSAFSVPQNSEPQAHISGGCDDSNRPTVWYHETLEWLKEEKRRDVHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQNFDLVIFYKVGKFYEMYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSVLEGDPSENYSKYLLSLKEKEEESSGHTRVYGVCFVDTSLGRFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGNLSMDTKMILKSSLSSSLQEGLIPGSQFWDAAKTLRTLLEEGYFTDKLNEDGGVMLPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYVPLDSDMVHATRPGAVFAKANQRMVLDAVTLNNLEIFLNGTNGSTEGTLLEKIDTCHTPFGKRLLKQWLCAPLCNPHAINDRLDAIEDLMVVPDKISEVVDLLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVICKIIGIMEEVIDDFKSKILKQVLTLQTKSPEGRFPDLTSELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRSRIGCRTIVYWGIGRNRYQLEIPENFITRNLPEEYELKSTKKGCKRYWTKTIEKKLGNLINAEERRDASLKDCMRRLFYNFDKNYKDWQAAVECIAVLDVLLCLTNYSRGGDGPMCRPIILLPEEDTPPFLDLKGSRHPCITKTFFGDDFIPNDILIGCEEEEEENGKAYCVLVTGPNMGGKSTLMRQAGLLAIMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILTHATAHSLVLVDELGRGTATFDGTAIANAVVKELAENIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFEKMTQSLRLFREVCLASERSTVDADAVHKLLTLIEEL", "length": 1378, "header": "tr|A0AAA9SZP1-1|E1B9Q4_BOVIN Computationally mapped isoform of DNA mismatch repair protein OS=Bos taurus OX=9913 GN=MSH6 PE=3 SV=1 CANONICAL=E1B9Q4-1" }, "locus": { "chromosome": "11", "start_pos": 30143364, "end_pos": 30122159, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096821.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096821.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091935.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091935.1" } ] } }, { "isoform_ac": "A0AAA9T6B7-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4/entry#A0AAA9T6B7-1", "sequence": { "sequence": "MSRQSTLFSFFPKSPAVNNANKAPVRASSGSSAAAAATGASPSPGGDAAWNEAGNLNGGLRKSASPAVPASSSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSARVHVQFFDDSPTRGWVSRRLLKPYTGSHSKEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEPSEPEEEEETEVGATYTSDKSEEENDIESEEEVRPKVQGSRRSSRQIKKRRVISDSESDVGGSDVEFKPDTKEEASSDEISSGVGDSDSEGLDTPVKVAPKRKRMVTGNGSLKRKSSRKEMPSATKRATGISSETKNTLSAFSVPQNSEPQAHISGGCDDSNRPTVWYHETLEWLKEEKRRDVHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQNFDLVIFYKVGKFYEMYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSVLEGDPSENYSKYLLSLKEKEEESSGHTRVYGVCFVDTSLGRFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGNLSMDTKMILKSSLSSSLQEGLIPGSQFWDAAKTLRTLLEEGYFTDKLNEDGGVMLPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYVPLDSDMVHATRPGAVFAKANQRMVLDAVTLNNLEIFLNGTNGSTEGTLLEKIDTCHTPFGKRLLKQWLCAPLCNPHAINDRLDAIEDLMVVPDKISEVVDLLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVICKIIGIMEEVIDDFKSKILKQVLTLQTKSPEGRFPDLTSELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRSRIGCRTIVYWGIGRNRYQLEIPENFITRNLPEEYELKSTKKGCKRYWTKTIEKKLGNLINAEERRDASLKDCMRRLFYNFDKNYKDWQAAVECIAVLDVLLCLTNYSRGGDGPMCRPIILLPEEDTPPFLDLKGSRHPCITKTFFGDDFIPNDILIGCEEEEEENGKAYCVLVTGPNMGGKSTLMRQAGLLAIMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILTHATAHSLVLVDELGRGTATFDGTAIANAVVKELAENIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFEKMTQSLRLFREVCLASERSTVDADAVHKLLTLIEEL", "length": 1347, "header": "tr|A0AAA9T6B7-1|E1B9Q4_BOVIN Computationally mapped isoform of DNA mismatch repair protein OS=Bos taurus OX=9913 GN=MSH6 PE=3 SV=1 CANONICAL=E1B9Q4-1" }, "locus": { "chromosome": "11", "start_pos": 30143364, "end_pos": 30122159, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105002.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105002.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092113.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092113.1" } ] } }, { "isoform_ac": "A0AAA9TC26-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4/entry#A0AAA9TC26-1", "sequence": { "sequence": "MDSLPTEPPKHGFSSSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSARVHVQFFDDSPTRGWVSRRLLKPYTGSHSKEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEPSEPEEEEETEVGATYTSDKSEEENDIESEEEVRPKVQGSRRSSRQIKKRRVISDSESDVGGSDVEFKPDTKEEASSDEISSGVGDSDSEGLDTPVKVAPKRKRMVTGNGSLKRKSSRKEMPSATKRATGISSETKNTLSAFSVPQNSEPQAHISGGCDDSNRPTVWYHETLEWLKEEKRRDVHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQNFDLVIFYKVGKFYEMYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSVLEGDPSENYSKYLLSLKEKEEESSGHTRVYGVCFVDTSLGRFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGNLSMDTKMILKSSLSSSLQEGLIPGSQFWDAAKTLRTLLEEGYFTDKLNEDGGVMLPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYVPLDSDMVHATRPGAVFAKANQRMVLDAVTLNNLEIFLNGTNGSTEGTLLEKIDTCHTPFGKRLLKQWLCAPLCNPHAINDRLDAIEDLMVVPDKISEVVDLLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVICKIIGIMEEVIDDFKSKILKQVLTLQTKSPEGRFPDLTSELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRSRIGCRTIVYWGIGRNRYQLEIPENFITRNLPEEYELKSTKKGCKRYWTKTIEKKLGNLINAEERRDASLKDCMRRLFYNFDKNYKDWQAAVECIAVLDVLLCLTNYSRGGDGPMCRPIILLPEEDTPPFLDLKGSRHPCITKTFFGDDFIPNDILIGCEEEEEENGKAYCVLVTGPNMGGKSTLMRQAGLLAIMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILTHATAHSLVLVDELGRGTATFDGTAIANAVVKELAENIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFEKMTQSLRLFREVCLASERSTVDADAVHKLLTLIEEL", "length": 1290, "header": "tr|A0AAA9TC26-1|E1B9Q4_BOVIN Computationally mapped isoform of DNA mismatch repair protein OS=Bos taurus OX=9913 GN=MSH6 PE=3 SV=1 CANONICAL=E1B9Q4-1" }, "locus": { "chromosome": "11", "start_pos": 30143364, "end_pos": 30109765, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110240.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110240.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094392.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094392.1" } ] } }, { "isoform_ac": "A0AAA9U0J2-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4/entry#A0AAA9U0J2-1", "sequence": { "sequence": 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"length": 1231, "header": "tr|A0ABI0P5Y3-1|A0ABI0P5Y3_BOVIN Computationally mapped isoform of DNA mismatch repair protein OS=Bos taurus OX=9913 GN=MSH6 PE=3 SV=1 CANONICAL=E1B9Q4-1" }, "locus": { "chromosome": "11", "start_pos": 30143364, "end_pos": 30122159, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000148872.1", "url": "https://www.ensembl.org/id/ENSBTAT00000148872.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106948.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106948.1" } ] } }, { "isoform_ac": "E1B9Q4-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4/entry#E1B9Q4-1", "sequence": { "sequence": "MSRQSTLFSFFPKSPAVNNANKAPVRASSGSSAAAAATGASPSPGGDAAWNEAGPEPLAGTTSRAEARNLNGGLRKSASPAVPASSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSARVHVQFFDDSPTRGWVSRRLLKPYTGSHSKEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEPSEPEEEEETEVGHCATYTSDKSEEENDIESEEEVRPKVQGSRRSSRQIKKRRVISDSESDVGGSDVEFKPDTKEEASSDEISSGVGDSDSEGLDTPVKVAPKRKRMVTGNGSLKRKSSRKEMPSATKRATGISSETKNTLSAFSVPQNSEPQAHISGGCDDSNRPTVWYHETLEWLKEEKRRDVHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQNFDLVIFYKVGKFYEMYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSVLEGDPSENYSKYLLSLKEKEEESSGHTRVYGVCFVDTSLGRFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGNLSMDTKMILKSSLSSSLQEGLIPGSQFWDAAKTLRTLLEEGYFTDKLNEDGGVMLPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYVPLDSDMVHATRPGAVFAKANQRMVLDAVTLNNLEIFLNGTNGSTEGTLLEKIDTCHTPFGKRLLKQWLCAPLCNPHAINDRLDAIEDLMVVPDKISEVVDLLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVICKIIGIMEEVIDDFKSKILKQVLTLQTKSPEGRFPDLTSELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRSRIGCRTIVYWGIGRNRYQLEIPENFITRNLPEEYELKSTKKGCKRYWTKTIEKKLGNLINAEERRDASLKDCMRRLFYNFDKNYKDWQAAVECIAVLDVLLCLTNYSRGGDGPMCRPIILLPEEDTPPFLDLKGSRHPCITKTFFGDDFIPNDILIGCEEEEEENGKAYCVLVTGPNMGGKSTLMRQAGLLAIMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILTHATAHSLVLVDELGRGTATFDGTAIANAVVKELAENIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFEKMTQSLRLFREVCLASERSTVDADAVHKLLTLIEEL", "length": 1362, "header": "tr|E1B9Q4-1|E1B9Q4_BOVIN Isoform 1 of DNA mismatch repair protein OS=Bos taurus OX=9913 GN=MSH6 PE=3 SV=4 CANONICAL=E1B9Q4-1" }, "locus": { "chromosome": "11", "start_pos": 30143364, "end_pos": 30122159, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001867.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001867.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001867.7", "url": "https://www.ensembl.org/id/ENSBTAP00000001867.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5358565", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5358565", "resource": "Reactome", "description": "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "MutSalpha complex", "id": "GO:0032301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032301", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 14, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" }, { "name": "mismatched DNA binding", "id": "GO:0030983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030983", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" }, { "name": "ATP-dependent DNA damage sensor activity", "id": "GO:0140664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140664", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" }, { "name": "oxidized purine DNA binding", "id": "GO:0032357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032357", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" }, { "name": "single guanine insertion binding", "id": "GO:0032142", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032142", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" }, { "name": "single thymine insertion binding", "id": "GO:0032143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032143", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" }, { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" }, { "name": "ADP binding", "id": "GO:0043531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043531", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" }, { "name": "four-way junction DNA binding", "id": "GO:0000400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000400", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" }, { "name": "MutLalpha complex binding", "id": "GO:0032405", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032405", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" }, { "name": "guanine/thymine mispair binding", "id": "GO:0032137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032137", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" }, { "name": "histone H3K36me3 reader activity", "id": "GO:0140003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140003", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mismatch repair", "id": "GO:0006298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006298", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" }, { "name": "negative regulation of DNA recombination", "id": "GO:0045910", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045910", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" }, { "name": "negative regulation of DNA metabolic process", "id": "GO:0051053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051053", "evidence": [ { "database": "UniProtKB", "id": "E1B9Q4", "url": "https://www.uniprot.org/uniprotkb/E1B9Q4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1066, "end_pos": 1068, "annotation": "n_glycosylation_sequon" }, { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" }, { "start_pos": 535, "end_pos": 537, "annotation": "n_glycosylation_sequon" }, { "start_pos": 601, "end_pos": 603, "annotation": "n_glycosylation_sequon" }, { "start_pos": 749, "end_pos": 751, "annotation": "n_glycosylation_sequon" }, { "start_pos": 752, "end_pos": 754, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": 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752, "end_pos": 754 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": 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"publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BC41-1", "uniprot_ac": "E1BC41", "uniprot_id": "E1BC41_BOVIN", "mass": { "chemical_mass": 161056.0, "monoisotopic_mass": 161056.0 }, "refseq": { "ac": "XP_005222595", "name": "kinesin-like protein KIF15 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222595" }, "gene_names": [ { "name": "KIF15", "type": "recommended", "evidence": [ { "id": "E1BC41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC41" } ] }, { "name": "KIF15", "type": "synonym", "evidence": [ { "id": "XP_005222595", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222595" } ] } ], "protein_names": [ { "name": "Kinesin-like protein KIF15", "type": "recommended", "evidence": [ { "id": "E1BC41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC41/entry#names_and_taxonomy" } ] }, { "name": "Kinesin-like protein 2", "type": "synonym", "evidence": [ { "id": "E1BC41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC41/entry#names_and_taxonomy" } ] }, { "name": "kinesin-like protein KIF15 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005222595", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222595" } ] } ], "function": [ { "annotation": "Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TJ76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ76#function" }, { "database": "UniProtKB", "id": "ARBA00057678", "url": "https://www.uniprot.org/uniprotkb/ARBA00057678#function" }, { "database": "UniProtKB", "id": "E1BC41", "url": "https://www.uniprot.org/uniprotkb/E1BC41#function" }, { "database": "UniProtKB", "id": "A0AAA9T2V7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2V7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BC41", "url": "https://www.uniprot.org/uniprotkb/E1BC41" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KIF15", "url": "https://www.uniprot.org/uniprotkb/E1BC41", "locus": { "chromosome": "22", "start_pos": 16564652, "end_pos": 16507963, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016726", "url": "https://www.ensembl.org/id/ENSBTAG00000016726" } ] } } ], "crossref": [ { "id": "ENSBTAG00000016726", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016726", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01373", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01373", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "541135", "url": "https://www.ncbi.nlm.nih.gov/gene/541135", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031794", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031794", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044986", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044986", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BC41", "url": "https://www.orthodb.org/?gene=E1BC41", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR37739", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37739", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37739:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37739:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00225", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00225", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15908", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15908", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2132295", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005222595", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222595", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S4E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4E2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4E2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4E2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2V7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2V7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2V7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2V7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ76-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC41", "url": "https://www.uniprot.org/uniprotkb/E1BC41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC41-1", "url": "https://www.uniprot.org/uniprotkb/E1BC41-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPGCKTELRSVTNCQSNQPSNEGDAIKVFVRIRPPIEGSGSADGEQNLCLSVLSSTTLRLHSNPEPKTFVFDHVANMDTTQESMFSTVAKGIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPRSFEYLFSLIEREKEKAGLGKSFLCKCSFIEIYNEHIYDLLDSASAGLYIREHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEKSHETVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHICYRDSKLTFLLRDSLGGNAKTVIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQGNVTQLQAEVKRLKEQLAQLTAGQMLPESLRTVDKDETNYIKYFREAMLFFKKSEQEKKSLVEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIMRLEKLHRESRGSFLPEEQDRLLSELRDEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAHEMDAQTIAILEKAFFEVSGTEKNDKSQVVSLLSGQQGFSPKALKEPCSLANTEKLKAQLLQVHTELNNSKQEYEEFKELTRKRQVELESEIQSLQKANLNLENLLEATKVCNRQEVSQLSKIHAETLKIITTPTKAYQLRSRPLLKFSPEPESFGSAQTQNSSNLDNDILSEPVPPEMSEQAFEAISEELRMVQEQMSALQVKLDEEEHKNVKLQQQIDKLEHHSTQMQELFSSERNDWTKQQLEHLSQLNVLEKQLQDTQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYTLFRESQEKELNSLSERHMQVQLQLDNVRLENEKLLESKTCLQDSYDNLQEVMKFEIDQLSKSLQNCKKENETLKSDLNNLMELFEAEKERNNKLLLQFEEDKENSSKEILEVLEAVRQEKQKEMAKCEQQMAKVQKLEESLCANEKVISSLEKSRDADKEVVTDLMSQIQELRTSVSEKTETIDTLRQELEDINGKYNSALADKEESKALINRQEADILDLKEALRLRILSEDIEKDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKDALIQELQHELNQKKEEVEQKKNEYNFKMRQLGHVMDSAVNYPQSPKTPPHFQTHLAKLLETQEQEIEDWKASKISLQHLITKLNEEREVKNAEILRIKEQLCEMENLRLEAEQLREKNWLLQGQLDDIKRQKDSSKQNHSDSQQLKNEQEEVIKERLAKNKLVEEMLKMKGDLEQLQSTLQNKETDYLTMTEEVKRVRMLEFKAFQEKEQLRSKFEELKEEKERTCQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLTEESEKLRAENLFLKERKKNEP", "length": 1396, "header": "tr|E1BC41-1|E1BC41_BOVIN Isoform 1 of Kinesin-like protein KIF15 OS=Bos taurus OX=9913 GN=KIF15 PE=3 SV=3 CANONICAL=E1BC41-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4E2-1", "url": "https://www.uniprot.org/uniprotkb/E1BC41/entry#A0AAA9S4E2-1", "sequence": { "sequence": "MAVVNEDTQGNVTQLQAEVKRLKEQLAQLTAGQMLPESLRTVDKDETNYIKYFREAMLFFKKSEQEKKSLVEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIMRLEKLHRESRGSFLPEEQDRLLSELRDEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAHEMDAQTIAILEKAFFEVSGTEKNDKSQQGFSPKALKEPCSLANTEKLKAQLLQVHTELNNSKQEYEEFKELTRKRQVELESEIQSLQKANLNLENLLEATKVCNRQEVSQLSKIHAETLKIITTPTKAYQLRSRPLLKFSPEPESFGSAQTQNSSNLDNDILSEPVPPEMSEQAFEAISEELRMVQEQMSALQVKLDEEEHKNVKLQQQIDKLEHHSTQMQELFSSERNDWTKQQLEHLSQLNVLEKQLQDTQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYTLFRESQEKELNSLSERHMQVQLQLDNVRLENEKLLESKTCLQDSYDNLQEVMKFEIDQLSKSLQNCKKENETLKSDLNNLMELFEAEKERNNKLLLQFEEDKENSSKEILEVLEAVRQEKQKEMAKCEQQMAKVQKLEESLCANEKVISSLEKSRDADKEVVTDLMSQIQELRTSVSEKTETIDTLRQELEDINGKYNSALADKEESKALINRQEADILDLKEALRLRILSEDIEKDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKDALIQELQHELNQKKEEVEQKKNEYNFKMRQLGHVMDSAVNYPQSPKTPPHFQTHLAKLLETQEQEIEDWKASKISLQHLITKLNEEREVKNAEILRIKEQLCEMENLRLEAEQLREKNWLLQGQLDDIKRQKDSSKQNHSDSQQLKNEQEEVIKERLAKNKLVEEMLKMKGDLEQLQSTLQNKETDYLTMTEEVKRVRMLEFKAFQEKEQLRSKFEELKEEKERTCQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLTEESEKLRAENLFLKERKKNEP", "length": 1023, "header": "tr|A0AAA9S4E2-1|E1BC41_BOVIN Computationally mapped isoform of Kinesin-like protein KIF15 OS=Bos taurus OX=9913 GN=KIF15 PE=3 SV=1 CANONICAL=E1BC41-1" }, "locus": { "chromosome": "22", "start_pos": 16564103, "end_pos": 16536698, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122706.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122706.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078680.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078680.1" } ] } }, { "isoform_ac": "A0AAA9T2V7-1", "url": "https://www.uniprot.org/uniprotkb/E1BC41/entry#A0AAA9T2V7-1", "sequence": { "sequence": "MAPGCKTELRSVTNCQSNQPSNEGDAIKVFVRIRPPIEGSGSADGEQNLCLSVLSSTTLRLHSNPEPKTFVFDHVANMDTTQESMFSTVAKGIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPRSFEYLFSLIEREKEKAGLGKSFLCKCSFIEIYNEHIYDLLDSASAGLYIREHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEKSHETVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHICYRDSKLTFLLRDSLGGNAKTVIIANVHPGSRCFGETLSTLNFAQRAKLIKNKVSAHQALLPLGFSRQEHWSGLPFPSPMHESEKVKAVVNEDTQGNVTQLQAEVKRLKEQLAQLTAGQMLPESLRTVDKDETNYIKYFREAMLFFKKSEQEKKSLVEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIMRLEKLHRESRGSFLPEEQDRLLSELRDEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAHEMDAQTIAILEKAFFEVSGTEKNDKSQVVSLLSGQQGFSPKALKEPCSLANTEKLKAQLLQVHTELNNSKQEYEEFKELTRKRQVELESEIQSLQKANLNLENLLEATKVCNRQEVSQLSKIHAETLKIITTPTKAYQLRSRPLLKFSPEPESFGSAQTQNSSNLDNDILSEPVPPEMSEQAFEAISEELRMVQEQMSALQVKLDEEEHKNVKLQQQIDKLEHHSTQMQELFSSERNDWTKQQLEHLSQLNVLEKQLQDTQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYTLFRESQEKELNSLSERHMQVQLQLDNVRLENEKLLESKTCLQDSYDNLQEVMKFEIDQLSKSLQNCKKENETLKSDLNNLMELFEAEKERNNKLLLQFEEDKENSSKEILEVLEAVRQEKQKEMAKCEQQMAKVQKLEESLCANEKVISSLEKSRDADKEVVTDLMSQIQELRTSVSEKTETIDTLRQELEDINGKYNSALADKEESKALINRQEADILDLKEALRLRILSEDIEKDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKDALIQELQHELNQKKEEVEQKKNEYNFKMRQLGHVMDSAVNYPQSPKTPPHFQTHLAKLLETQEQEIEDWKASKISLQHLITKLNEEREVKNAEILRIKEQLCEMENLRLEAEQLREKNWLLQGQLDDIKRQKDSSKQNHSDSQQLKNEQEEVIKERLAKNKLVEEMLKMKGDLEQLQSTLQNKETDYLTMTEEVKRVRMLEFKAFQEKEQLRSKFEELKEEKERTCQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLTEESEKLRAENLFLKERKKNEP", "length": 1430, "header": "tr|A0AAA9T2V7-1|E1BC41_BOVIN Computationally mapped isoform of Kinesin-like protein KIF15 OS=Bos taurus OX=9913 GN=KIF15 PE=3 SV=1 CANONICAL=E1BC41-1" }, "locus": { "chromosome": "22", "start_pos": 16564103, "end_pos": 16508007, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116322.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116322.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090796.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090796.1" } ] } }, { "isoform_ac": "A0AAA9TJ76-1", "url": "https://www.uniprot.org/uniprotkb/E1BC41/entry#A0AAA9TJ76-1", "sequence": { "sequence": "MAPSLHRPSESDNFSHNLRGVIPRSFEYLFSLIEREKEKAGLGKSFLCKCSFIEIYNEHIYDLLDSASAGLYIREHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEKSHETVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHICYRDSKLTFLLRDSLGGNAKTVIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQGNVTQLQAEVKRLKEQLAQLTAGQMLPESLRTVDKDETNYIKYFREAMLFFKKSEQEKKSLVEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIMRLEKLHRESRGSFLPEEQDRLLSELRDEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAHEMDAQTIAILEKAFFEVSGTEKNDKSQVVSLLSGQQGFSPKALKEPCSLANTEKLKAQLLQVHTELNNSKQEYEEFKELTRKRQVELESEIQSLQKANLNLENLLEATKVCNRQEVSQLSKIHAETLKIITTPTKAYQLRSRPLLKFSPEPESFGSAQTQNSSNLDNDILSEPVPPEMSEQAFEAISEELRMVQEQMSALQVKLDEEEHKNVKLQQQIDKLEHHSTQMQELFSSERNDWTKQQLEHLSQLNVLEKQLQDTQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYTLFRESQEKELNSLSERHMQVQLQLDNVRLENEKLLESKTCLQDSYDNLQEVMKFEIDQLSKSLQNCKKENETLKSDLNNLMELFEAEKERNNKLLLQFEEDKENSSKEILEVLEAVRQEKQKEMAKCEQQMAKVQKLEESLCANEKVISSLEKSRDADKEVVTDLMSQIQELRTSVSEKTETIDTLRQELEDINGKYNSALADKEESKALINRQEADILDLKEALRLRILSEDIEKDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKDALIQELQHELNQKKEEVEQKKNEYNFKMRQLGHVMDSAVNYPQSPKTPPHFQTHLAKLLETQEQEIEDWKASKISLQHLITKLNEEREVKNAEILRIKEQLCEMENLRLEAEQLREKNWLLQGQLDDIKRQKDSSKQNHSDSQQLKNEQEEVIKERLAKNKLVEEMLKMKGDLEQLQSTLQNKETDYLTMTEEVKRVRMLEFKAFQEKEQLRSKFEELKEEKERTCQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLTEESEKLRAENLFLKERKKNEP", "length": 1282, "header": "tr|A0AAA9TJ76-1|E1BC41_BOVIN Computationally mapped isoform of Kinesin-like protein KIF15 OS=Bos taurus OX=9913 GN=KIF15 PE=3 SV=1 CANONICAL=E1BC41-1" }, "locus": { "chromosome": "22", "start_pos": 16564103, "end_pos": 16522794, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124281.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124281.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096292.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096292.1" } ] } }, { "isoform_ac": "E1BC41-1", "url": "https://www.uniprot.org/uniprotkb/E1BC41/entry#E1BC41-1", "sequence": { "sequence": "MAPGCKTELRSVTNCQSNQPSNEGDAIKVFVRIRPPIEGSGSADGEQNLCLSVLSSTTLRLHSNPEPKTFVFDHVANMDTTQESMFSTVAKGIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPRSFEYLFSLIEREKEKAGLGKSFLCKCSFIEIYNEHIYDLLDSASAGLYIREHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEKSHETVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHICYRDSKLTFLLRDSLGGNAKTVIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQGNVTQLQAEVKRLKEQLAQLTAGQMLPESLRTVDKDETNYIKYFREAMLFFKKSEQEKKSLVEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIMRLEKLHRESRGSFLPEEQDRLLSELRDEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAHEMDAQTIAILEKAFFEVSGTEKNDKSQVVSLLSGQQGFSPKALKEPCSLANTEKLKAQLLQVHTELNNSKQEYEEFKELTRKRQVELESEIQSLQKANLNLENLLEATKVCNRQEVSQLSKIHAETLKIITTPTKAYQLRSRPLLKFSPEPESFGSAQTQNSSNLDNDILSEPVPPEMSEQAFEAISEELRMVQEQMSALQVKLDEEEHKNVKLQQQIDKLEHHSTQMQELFSSERNDWTKQQLEHLSQLNVLEKQLQDTQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYTLFRESQEKELNSLSERHMQVQLQLDNVRLENEKLLESKTCLQDSYDNLQEVMKFEIDQLSKSLQNCKKENETLKSDLNNLMELFEAEKERNNKLLLQFEEDKENSSKEILEVLEAVRQEKQKEMAKCEQQMAKVQKLEESLCANEKVISSLEKSRDADKEVVTDLMSQIQELRTSVSEKTETIDTLRQELEDINGKYNSALADKEESKALINRQEADILDLKEALRLRILSEDIEKDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKDALIQELQHELNQKKEEVEQKKNEYNFKMRQLGHVMDSAVNYPQSPKTPPHFQTHLAKLLETQEQEIEDWKASKISLQHLITKLNEEREVKNAEILRIKEQLCEMENLRLEAEQLREKNWLLQGQLDDIKRQKDSSKQNHSDSQQLKNEQEEVIKERLAKNKLVEEMLKMKGDLEQLQSTLQNKETDYLTMTEEVKRVRMLEFKAFQEKEQLRSKFEELKEEKERTCQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLTEESEKLRAENLFLKERKKNEP", "length": 1396, "header": "tr|E1BC41-1|E1BC41_BOVIN Isoform 1 of Kinesin-like protein KIF15 OS=Bos taurus OX=9913 GN=KIF15 PE=3 SV=3 CANONICAL=E1BC41-1" }, "locus": { "chromosome": "22", "start_pos": 16564103, "end_pos": 16508007, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000060943.5", "url": "https://www.ensembl.org/id/ENSBTAT00000060943.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053783.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053783.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-2132295", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "resource": "Reactome", "description": "MHC class II antigen presentation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1BC41", "url": "https://www.uniprot.org/uniprotkb/E1BC41" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "E1BC41", "url": "https://www.uniprot.org/uniprotkb/E1BC41" } ], "pmid": "" }, { "name": "microtubule motor activity", "id": "GO:0003777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003777", "evidence": [ { "database": "UniProtKB", "id": "E1BC41", "url": "https://www.uniprot.org/uniprotkb/E1BC41" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "E1BC41", "url": "https://www.uniprot.org/uniprotkb/E1BC41" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "E1BC41", "url": "https://www.uniprot.org/uniprotkb/E1BC41" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "E1BC41", "url": "https://www.uniprot.org/uniprotkb/E1BC41" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "E1BC41", "url": "https://www.uniprot.org/uniprotkb/E1BC41" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BC41", "url": "https://www.uniprot.org/uniprotkb/E1BC41" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BC41", "url": "https://www.uniprot.org/uniprotkb/E1BC41" } ], "pmid": "" }, { "name": "kinesin complex", "id": "GO:0005871", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005871", "evidence": [ { "database": "UniProtKB", "id": "E1BC41", "url": "https://www.uniprot.org/uniprotkb/E1BC41" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitotic cell cycle", "id": "GO:0000278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", "evidence": [ { "database": "UniProtKB", "id": "E1BC41", "url": "https://www.uniprot.org/uniprotkb/E1BC41" } ], "pmid": "" }, { "name": "microtubule-based movement", "id": "GO:0007018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007018", "evidence": [ { "database": "UniProtKB", "id": "E1BC41", "url": "https://www.uniprot.org/uniprotkb/E1BC41" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1243, "end_pos": 1245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 289, "end_pos": 291, "annotation": "n_glycosylation_sequon" }, { "start_pos": 376, "end_pos": 378, "annotation": "n_glycosylation_sequon" }, { "start_pos": 517, "end_pos": 519, "annotation": "n_glycosylation_sequon" }, { "start_pos": 604, "end_pos": 606, "annotation": "n_glycosylation_sequon" }, { "start_pos": 698, "end_pos": 700, "annotation": "n_glycosylation_sequon" }, { "start_pos": 900, "end_pos": 902, "annotation": "n_glycosylation_sequon" }, { "start_pos": 934, "end_pos": 936, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BC41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC41" }, { "id": "PS50067", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50067" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kinesin motor", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 363, "start_aa": "Ala", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 1243, "end_pos": 1245 }, { "start_pos": 127, "end_pos": 129 }, { "start_pos": 289, "end_pos": 291 }, { "start_pos": 376, "end_pos": 378 }, { "start_pos": 517, "end_pos": 519 }, { "start_pos": 604, "end_pos": 606 }, { "start_pos": 698, "end_pos": 700 }, { "start_pos": 900, "end_pos": 902 }, { "start_pos": 934, "end_pos": 936 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", 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"total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BC70-1", "uniprot_ac": "E1BC70", "uniprot_id": "E1BC70_BOVIN", "mass": { "chemical_mass": 38070.0, "monoisotopic_mass": 38070.0 }, "refseq": { "ac": "NP_001193079", "name": "vacuolar protein sorting-associated protein 37C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193079" }, "gene_names": [ { "name": "VPS37C", "type": "recommended", "evidence": [ { "id": "E1BC70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC70" } ] }, { "name": "VPS37C", "type": "synonym", "evidence": [ { "id": "NP_001193079", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193079" } ] } ], "protein_names": [ { "name": "VPS37C subunit of ESCRT-I", "type": "synonym", "evidence": [ { "id": "E1BC70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC70/entry#names_and_taxonomy" } ] }, { "name": "VPS37C, ESCRT-I subunit", "type": "synonym", "evidence": [ { "id": "NP_001193079", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193079" } ] }, { "name": "vacuolar protein sorting-associated protein 37C", "type": "synonym", "evidence": [ { "id": "NP_001193079", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193079" } ] } ], "function": [ { "annotation": "Component of the ESCRT-I complex, a regulator of vesicular trafficking process. 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{ "name": "VPS37C", "url": "https://www.uniprot.org/uniprotkb/E1BC70", "locus": { "chromosome": "29", "start_pos": 37451425, "end_pos": 37481097, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008064", "url": "https://www.ensembl.org/id/ENSBTAG00000008064" } ] } } ], "crossref": [ { "id": "E1BC70", "url": "https://alphafold.ebi.ac.uk/entry/E1BC70", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008064", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008064", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613817", "url": "https://www.ncbi.nlm.nih.gov/gene/613817", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009851", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613817", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613817", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PMYRAGY", "url": "https://omabrowser.org/oma/group/PMYRAGY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BC70", "url": "https://www.orthodb.org/?gene=E1BC70", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13678", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13678", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13678:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13678:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07200", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07200", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-917729", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-917729", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193079", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5E6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5E6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5E6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNZ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNZ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNZ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNZ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THD4", "url": 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PE=3 SV=1 CANONICAL=E1BC70-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5E6-1", "url": "https://www.uniprot.org/uniprotkb/E1BC70/entry#A0AAA9S5E6-1", "sequence": { "sequence": "MFQFLAHFGGKMETLKDKTLEELEEMQNDPEAIDRLAQDSPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDKYQELRKLVERYQEQKAKLEKFSSALQLGTLLDLLQIESMKIEEESEAMAEKFLEGEVPLDTFLENFSSMRTLSHLRRVRVEKLQDVMKKPRASLEPAGDTPPPRPPPPLHPGPQTTPPPAEDAQPQPPQPSVVPPYPLPYSPSPGMPVGPTAHGALPPAPFPVVSQPSFSYSGPLGPPYAAAQPGTRAPSGYSWSPQRSMPPRPGYPVAPTGASGPGYPVVGGRAPSPGYPQQPPYLSTGGKPPYPTQPQPSGPLQPPYPPGPAPPYGFPPPQGPTWPGY", "length": 361, "header": "tr|A0AAA9S5E6-1|E1BC70_BOVIN Computationally mapped isoform of VPS37C subunit of ESCRT-I OS=Bos taurus OX=9913 GN=VPS37C PE=3 SV=1 CANONICAL=E1BC70-1" }, "locus": { "chromosome": "29", "start_pos": 37464933, "end_pos": 37452498, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100733.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100733.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081167.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081167.1" } ] } }, { "isoform_ac": "A0AAA9SNZ0-1", "url": "https://www.uniprot.org/uniprotkb/E1BC70/entry#A0AAA9SNZ0-1", "sequence": { "sequence": "MGRGPRKPALPSKQASCSGKMETLKDKTLEELEEMQNDPEAIDRLAQDSPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDKYQELRKLVERYQEQKAKLEKFSSALQLGTLLDLLQIESMKIEEESEAMAEKFLEGEVPLDTFLENFSSMRTLSHLRRVRVEKLQDVMKKPRASLEPAGDTPPPRPPPPLHPGPQTTPPPAEDAQPQPPQPSVVPPYPLPYSPSPGMPVGPTAHGALPPAPFPVVSQPSFSYSGPLGPPYAAAQPGTRAPSGYSWSPQRSMPPRPGYPVAPTGASGPGYPVVGGRAPSPGYPQQPPYLSTGGKPPYPTQPQPSGPLQPPYPPGPAPPYGFPPPQGPTWPGY", "length": 370, "header": "tr|A0AAA9SNZ0-1|E1BC70_BOVIN Computationally mapped isoform of VPS37C subunit of ESCRT-I OS=Bos taurus OX=9913 GN=VPS37C PE=3 SV=1 CANONICAL=E1BC70-1" }, "locus": { "chromosome": "29", "start_pos": 37459236, "end_pos": 37452498, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133989.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133989.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088046.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088046.1" } ] } }, { "isoform_ac": "A0AAA9THD4-1", "url": "https://www.uniprot.org/uniprotkb/E1BC70/entry#A0AAA9THD4-1", "sequence": { "sequence": "METLKDKTLEELEEMQNDPEAIDRLAQDSPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDKYQELRKLVERYQEQKAKLEKFSSALQLGTLLDLLQIESMKIEEESEAMAEKFLEGEVPLDTFLENFSSMRTLSHLRRVRVEKLQDVMKKPRASLEPAGDTPPPRPPPPLHPGPQTTPPPAEDAQPQPPQPSVVPPYPLPYSPSPGMPVGPTAHGALPPAPFPVVSQPSFSYSGPLGPPYAAAQPGTRAPSGYSWSPQRSMPPRPGYPVAPTGASGPGYPVVGGRAPSPGYPQQPPYLSTGGKPPYPTQPQPSALPYSHLYHSLQPTPC", "length": 338, "header": "tr|A0AAA9THD4-1|E1BC70_BOVIN Computationally mapped isoform of VPS37C subunit of ESCRT-I OS=Bos taurus OX=9913 GN=VPS37C PE=3 SV=1 CANONICAL=E1BC70-1" }, "locus": { "chromosome": "29", "start_pos": 37458547, "end_pos": 37452429, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092633.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092633.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097657.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097657.1" } ] } }, { "isoform_ac": "E1BC70-1", "url": "https://www.uniprot.org/uniprotkb/E1BC70/entry#E1BC70-1", "sequence": { "sequence": "METLKDKTLEELEEMQNDPEAIDRLAQDSPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDKYQELRKLVERYQEQKAKLEKFSSALQLGTLLDLLQIESMKIEEESEAMAEKFLEGEVPLDTFLENFSSMRTLSHLRRVRVEKLQDVMKKPRASLEPAGDTPPPRPPPPLHPGPQTTPPPAEDAQPQPPQPSVVPPYPLPYSPSPGMPVGPTAHGALPPAPFPVVSQPSFSYSGPLGPPYAAAQPGTRAPSGYSWSPQRSMPPRPGYPVAPTGASGPGYPVVGGRAPSPGYPQQPPYLSTGGKPPYPTQPQPSGPLQPPYPPGPAPPYGFPPPQGPTWPGY", "length": 350, "header": "tr|E1BC70-1|E1BC70_BOVIN Isoform 1 of VPS37C subunit of ESCRT-I OS=Bos taurus OX=9913 GN=VPS37C PE=3 SV=1 CANONICAL=E1BC70-1" }, "locus": { "chromosome": "29", "start_pos": 37458547, "end_pos": 37452498, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010607.6", "url": "https://www.ensembl.org/id/ENSBTAT00000010607.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010607.4", "url": "https://www.ensembl.org/id/ENSBTAP00000010607.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 170, "start_aa": "Thr", "end_pos": 170, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr170", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 221, "start_aa": "Thr", "end_pos": 221, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr221", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 281, "start_aa": "Thr", "end_pos": 281, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr281", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 317, "start_aa": "Thr", "end_pos": 317, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr317", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 346, "start_aa": "Thr", "end_pos": 346, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr346", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:613817", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613817", "resource": "KEGG Pathway" }, { "id": "R-BTA-917729", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-917729", "resource": "Reactome", "description": "Endosomal Sorting Complex Required For Transport (ESCRT)" } ], "orthologs": [ { "uniprot_canonical_ac": "A5D8V6-1", "protein_name": "Vacuolar protein sorting-associated protein 37C", "gene_name": "VPS37C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METLKDKTLQELEELQNDSEAIDQLALESPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDRYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQVEGMKIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVRVEKLQEVVRKPRASQELAGDAPPPRPPPPVRPVPQGTPPVVEEQPQPPLAMPPYPLPYSPSPSLPVGPTAHGALPPAPFPVVSQPSFYSGPLGPTYPAAQLGPRGAAGYSWSPQRSMPPRPGYPGTPMGASGPGYPLRGGRAPSPGYPQQSPYPATGGKPPYPIQPQLPSFPGQPQPSVPLQPPYPPGPAPPYGFPPPPGPAWPGY", "length": 355 }, "evidence": [ { "id": "E1BC70", "url": "https://omabrowser.org/oma/group/E1BC70/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "B5DFF4-1", "protein_name": "VPS37C subunit of ESCRT-I", "gene_name": "Vps37c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEGLKDKTLQELEEMQNDPEAIARLALESPEVQDLQLEREMALATNRSLAEQNLEFQGPLEISRSNLSDKYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQIEGMKIEEESEAMAEKFLEGEVPLETFLESFSSMRTLLHLRRVRVEKLQDVVRRPRALPELAGDAPPKRPPPPRPAPQAAPPETEEQTPQPSVVTPYPLPYSPSPGLPVGPTAQGALQPAPFPVVTQPSSYGGPLGPSYPSPQPGPRAMVGYSWSPQRSGPPRPGYPVAPTSTSGPGYPLVGGQTPGPGYPQQSPYFPSGSKPPYPTQPQLPGFPGQPPPPVPPQPPYPSGVTPPYGFHPPGSAWPRY", "length": 353 }, "evidence": [ { "id": "E1BC70", "url": "https://omabrowser.org/oma/group/E1BC70/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3IM56-1", "protein_name": "Vacuolar protein sorting-associated protein 37C", "gene_name": "Vps37c", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEGLKDKTLQELEEMQNDPEAIARLALESPEVQDLQLEREMALATNRSLAEQNLEFQGPLEISRSNLSDKYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQIEGMKIEEESEAMAEKFLEGEVPLETFLESFSSMRTLLHLRRVRVEKLQEVVRRPRVLPELAGDAPPPRPPPPRPAPQATPPVTEEQPPQPSVVTPYPLPYSPSPGLPVGPTAQGALQPAPFPVVAQPSSYSRPVGPSYPSPQPAPRAAMGYSWSPQRSVPPRPGYPVAPTSTSGPGYPLVGSLAPAPGYPQQSPYLPSQSKPPYPTQPQLPGFPGQPQPPVPPQPPYPSGPTPPYGFHPPGPAWPRY", "length": 353 }, "evidence": [ { "id": "E1BC70", "url": "https://omabrowser.org/oma/group/E1BC70/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8R105-1", "protein_name": "Vacuolar protein sorting-associated protein 37C", "gene_name": "Vps37c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGLKDKTLQELEEMQNDPEAIARLALESPEVQDLQLEREMALATNRSLAEQNLEFQGPLEISRSNLSDKYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQIEGMKIEEESEAMAEKFLEGEVPLETFLESFSSMRTLLHLRRVRVEKLQDVVRRPRALPELAGDVPPKRPPPPRPVPQATPPETEEQPPQPSVVTPYPLPYSPSPGLPVGPTAQGALQPAPFPVVAQPSSYGGPLGPYPSPHPGPRAMVGYSWSPQRSGPPQPGYPTAPTSTSGPGYPLVGGRTPGPGYPQQSPYLPSGNKPPYPTQPQLPGFPGQPQPPVPPQPPYPPGTTPSYGFHPPGPAWPRY", "length": 352 }, "evidence": [ { "id": "E1BC70", "url": "https://omabrowser.org/oma/group/E1BC70/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "multivesicular body assembly", "id": "GO:0036258", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036258", "evidence": [ { "database": "UniProtKB", "id": "E1BC70", "url": "https://www.uniprot.org/uniprotkb/E1BC70" } ], "pmid": "" }, { "name": "viral budding via host ESCRT complex", "id": "GO:0039702", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0039702", "evidence": [ { "database": "UniProtKB", "id": "E1BC70", "url": "https://www.uniprot.org/uniprotkb/E1BC70" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "E1BC70", "url": "https://www.uniprot.org/uniprotkb/E1BC70" } ], "pmid": "" }, { "name": "macroautophagy", "id": "GO:0016236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016236", "evidence": [ { "database": "UniProtKB", "id": "E1BC70", "url": "https://www.uniprot.org/uniprotkb/E1BC70" } ], "pmid": "" }, { "name": "protein targeting to membrane", "id": "GO:0006612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006612", "evidence": [ { "database": "UniProtKB", "id": "E1BC70", "url": "https://www.uniprot.org/uniprotkb/E1BC70" } ], "pmid": "" }, { "name": "protein targeting to vacuole", "id": "GO:0006623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006623", "evidence": [ { "database": "UniProtKB", "id": "E1BC70", "url": "https://www.uniprot.org/uniprotkb/E1BC70" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "id": "GO:0043162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043162", "evidence": [ { "database": "UniProtKB", "id": "E1BC70", "url": "https://www.uniprot.org/uniprotkb/E1BC70" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium-dependent protein binding", "id": "GO:0048306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048306", "evidence": [ { "database": "UniProtKB", "id": "E1BC70", "url": "https://www.uniprot.org/uniprotkb/E1BC70" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "E1BC70", "url": "https://www.uniprot.org/uniprotkb/E1BC70" } ], "pmid": "" }, { "name": "ESCRT I complex", "id": "GO:0000813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000813", "evidence": [ { "database": "UniProtKB", "id": "E1BC70", "url": "https://www.uniprot.org/uniprotkb/E1BC70" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BC70", "url": "https://www.uniprot.org/uniprotkb/E1BC70" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" }, { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" }, { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BC70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC70" }, { "id": "PS51314", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51314" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VPS37 C-terminal", "eco_id": "ECO_0000259", "start_pos": 78, "end_pos": 167, "start_aa": "Val", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 170, 221, 281, 317, 346 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 135, "end_pos": 137 }, { "start_pos": 46, "end_pos": 48 }, { "start_pos": 66, "end_pos": 68 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_o_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_o_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A7YWD2-1", "uniprot_ac": "A7YWD2", "uniprot_id": "IPO13_BOVIN", "mass": { "chemical_mass": 108139.0, "monoisotopic_mass": 108139.0 }, "refseq": { "ac": "NP_001098860", "name": "importin-13", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098860" }, "gene_names": [ { "name": "IPO13", "type": "recommended", "evidence": [ { "id": "A7YWD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWD2" } ] }, { "name": "IPO13", "type": "synonym", "evidence": [ { "id": "NP_001098860", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098860" } ] }, { "name": "Imp13", "type": "synonym", "evidence": [ { "id": "NP_001098860", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098860" } ] } ], "protein_names": [ { "name": "Importin-13", "type": "recommended", "evidence": [ { "id": "A7YWD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWD2/entry#names_and_taxonomy" } ] }, { "name": "Imp13", "type": "synonym", "evidence": [ { "id": "A7YWD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWD2/entry#names_and_taxonomy" } ] }, { "name": "importin-13", "type": "synonym", "evidence": [ { "id": "NP_001098860", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098860" } ] } ], "function": [ { "annotation": "Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A7YWD2", "url": "https://www.uniprot.org/uniprotkb/A7YWD2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7YWD2", "url": "https://www.uniprot.org/uniprotkb/A7YWD2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IPO13", "url": "https://www.uniprot.org/uniprotkb/A7YWD2", "locus": { "chromosome": "3", "start_pos": 102096298, "end_pos": 102111251, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018887", "url": "https://www.ensembl.org/id/ENSBTAG00000018887" } ] } } ], "crossref": [ { "id": "A7YWD2", "url": "https://alphafold.ebi.ac.uk/entry/A7YWD2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018887", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018887", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "523399", "url": "https://www.ncbi.nlm.nih.gov/gene/523399", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001494", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001494", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040520", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040520", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040709", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040944", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040944", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051345", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051345", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057941", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057941", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058537", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058537", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523399", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523399", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KYPAEMA", "url": "https://omabrowser.org/oma/group/KYPAEMA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A7YWD2", "url": "https://www.orthodb.org/?gene=A7YWD2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12363", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12363", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12363:SF33", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12363:SF33", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03810", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03810", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08389", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08389", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18773", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18773", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18786", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18786", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18806", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18806", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24138", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24138", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24139", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24139", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24140", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24140", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001098860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098860", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SAA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5Q2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Q2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z5Q2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5Q2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NTG2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NTG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NTG2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NTG2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NUX0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NUX0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUX0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXL1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXL1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXL1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6D1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6D1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6D1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6D1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7YWD2", "url": "https://www.uniprot.org/uniprotkb/A7YWD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7YWD2-1", "url": "https://www.uniprot.org/uniprotkb/A7YWD2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQASPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDSQGRCLALLELLTVLPEEFQTSRLPQYRKSLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQDQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHFPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSISSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDVSHHEDDHEGSELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEVEPVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSVWIKEALQAPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY", "length": 963, "header": "sp|A7YWD2-1|IPO13_BOVIN Isoform 1 of Importin-13 OS=Bos taurus OX=9913 GN=IPO13 PE=2 SV=1 CANONICAL=A7YWD2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAA6-1", "url": "https://www.uniprot.org/uniprotkb/A7YWD2/entry#A0AAA9SAA6-1", "sequence": { "sequence": "MILRVDGWAYQLHLLQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEVEPVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSVWIKEALQAPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY", "length": 180, "header": "tr|A0AAA9SAA6-1|IPO13_BOVIN Computationally mapped isoform of Importin-13 OS=Bos taurus OX=9913 GN=IPO13 PE=2 SV=1 CANONICAL=A7YWD2-1" }, "locus": { "chromosome": "3", "start_pos": 102092860, "end_pos": 102091699, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108313.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108313.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080355.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080355.1" } ] } }, { "isoform_ac": "A0AAF6Z5Q2-1", "url": "https://www.uniprot.org/uniprotkb/A7YWD2/entry#A0AAF6Z5Q2-1", "sequence": { "sequence": "MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQASPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDSQGRCLALLELLTVLPEEFQTSRLPQYRKSLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQDQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHFPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSISSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDVSHHEDDHEGSELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFPPERVDQGGASGTWLSLCPPQPRTEGHLQPTDPSRASKQEAGEGDGERIHTAVPGATWHRLHS", "length": 904, "header": "tr|A0AAF6Z5Q2-1|IPO13_BOVIN Computationally mapped isoform of Importin-13 OS=Bos taurus OX=9913 GN=IPO13 PE=2 SV=2 CANONICAL=A7YWD2-1" }, "locus": { "chromosome": "3", "start_pos": 102110666, "end_pos": 102091706, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025142.8", "url": "https://www.ensembl.org/id/ENSBTAT00000025142.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025142.7", "url": "https://www.ensembl.org/id/ENSBTAP00000025142.7" } ] } }, { "isoform_ac": "A0ABI0NTG2-1", "url": "https://www.uniprot.org/uniprotkb/A7YWD2/entry#A0ABI0NTG2-1", "sequence": { "sequence": "MRTTFPRALHQLYYDPNIENKNLAQKWLMQAQASPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDSQGRCLALLELLTVLPEEFQTSRLPQYRKSLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQDQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHFPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSISSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDVSHHEDDHEGSELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEVEPVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSVWIKEALQAPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY", "length": 942, "header": "tr|A0ABI0NTG2-1|A0ABI0NTG2_BOVIN Computationally mapped isoform of Importin-13 OS=Bos taurus OX=9913 GN=IPO13 PE=3 SV=1 CANONICAL=A7YWD2-1" }, "locus": { "chromosome": "3", "start_pos": 102111604, "end_pos": 102091699, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147273.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147273.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104026.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104026.1" } ] } }, { "isoform_ac": "A0ABI0NUX0-1", "url": "https://www.uniprot.org/uniprotkb/A7YWD2/entry#A0ABI0NUX0-1", "sequence": { "sequence": "MLWALAGSRVALHQLYYDPNIENKNLAQKWLMQAQASPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDSQGRCLALLELLTVLPEEFQTSRLPQYRKSLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQDQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHFPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSISSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDVSHHEDDHEGSELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEVEPVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSVWIKEALQAPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY", "length": 945, "header": "tr|A0ABI0NUX0-1|A0ABI0NUX0_BOVIN Computationally mapped isoform of Importin-13 OS=Bos taurus OX=9913 GN=IPO13 PE=3 SV=1 CANONICAL=A7YWD2-1" }, "locus": { "chromosome": "3", "start_pos": 102108833, "end_pos": 102091699, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151995.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151995.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105088.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105088.1" } ] } }, { "isoform_ac": "A0ABI0NXL1-1", "url": "https://www.uniprot.org/uniprotkb/A7YWD2/entry#A0ABI0NXL1-1", "sequence": { "sequence": "MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQASPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDSQGRCLALLELLTVLPEEFQTSRLPQYRKSLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQDQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHFPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYSQASGILFPQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSISSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDVSHHEDDHEGSELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEVEPVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSVWIKEALQAPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY", "length": 932, "header": "tr|A0ABI0NXL1-1|A0ABI0NXL1_BOVIN Computationally mapped isoform of Importin-13 OS=Bos taurus OX=9913 GN=IPO13 PE=3 SV=1 CANONICAL=A7YWD2-1" }, "locus": { "chromosome": "3", "start_pos": 102110666, "end_pos": 102091699, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000140061.1", "url": "https://www.ensembl.org/id/ENSBTAT00000140061.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105576.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105576.1" } ] } }, { "isoform_ac": "A0ABI0P6D1-1", "url": "https://www.uniprot.org/uniprotkb/A7YWD2/entry#A0ABI0P6D1-1", "sequence": { "sequence": "MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQASPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDSQGRCLALLELLTVLPEEFQTSRLPQYRKSLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQDQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHFPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSISSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEVEPVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSVWIKEALQAPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY", "length": 915, "header": "tr|A0ABI0P6D1-1|A0ABI0P6D1_BOVIN Computationally mapped isoform of Importin-13 OS=Bos taurus OX=9913 GN=IPO13 PE=3 SV=1 CANONICAL=A7YWD2-1" }, "locus": { "chromosome": "3", "start_pos": 102110666, "end_pos": 102091699, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154475.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154475.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106738.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106738.1" } ] } }, { "isoform_ac": "A7YWD2-1", "url": "https://www.uniprot.org/uniprotkb/A7YWD2/entry#A7YWD2-1", "sequence": { "sequence": "MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQASPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDSQGRCLALLELLTVLPEEFQTSRLPQYRKSLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQDQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHFPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSISSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDVSHHEDDHEGSELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEVEPVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSVWIKEALQAPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY", "length": 963, "header": "sp|A7YWD2-1|IPO13_BOVIN Isoform 1 of Importin-13 OS=Bos taurus OX=9913 GN=IPO13 PE=2 SV=1 CANONICAL=A7YWD2-1" }, "locus": { "chromosome": "3", "start_pos": 102110666, "end_pos": 102091699, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147116.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147116.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106579.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106579.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:523399", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523399", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1Q9F5-1", "protein_name": "Importin-13", "gene_name": "ipo13b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDSDTAADFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWQFCWVLLRPDKVPEIQYFGASALHTKISRYWSDIPAEQYDSLKSQLFSQIARFASGSKIVLTRLCVALASLALNMMPEAWPGAVSEMVRMFQEDGGDVDGRARCLALLELLTVLPEEFQTSRLPQYRKGQVRGALGSEWTAVYPLLQQLLRQPDSPSLVKARVLKCLSSWVLLDVPLNESEGLVEASFTALADPELFDTAVEAIVNTISQPDSQRYVNTLLKLVPQVLQLQEQLRDAVQNGDMETSHGICRIAVSLGENHSRALLEQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDIMSFEAEKQAVYLQVYRPVYFQLVDVLLHKAQFPTDEEYASWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTNTEQTTTWQHTEALLYGFQSIAETIDVNYSDVIPGLIGLIPRININNVQLADTVMFTIGALAEWLADHPVMLSSVLPLVLQALGNPDLSVSSVSTLKKICRECKYDLPPYATNIVAVSQEVLIKQIHKTSQCMWLMQALGFLLSALPVEEILRNLHSLITPYIQQLEKLAEETPNPSNKLAIIHILGLLSNLFTTLDITKQEDESGENAPPIKSAPPPTGPNPVVVVLQQVFALIQTVLSKWLNDSQVVEAVCAIFEKSVKTLLHDFAPMVSQLSEMLGQMYSTIPQASALDLTRQMVHIFASETNHFPPIKALFELVTSVTLTIFQQGPRDHPDIVDSFMQLQAQALKRKPDLFLSENLDVKAVFHCGVLSLKFPEAPTVKSTCLFFSELIPHCADIPPLARVVQEDGKLLLVAVLEAIGGQSSRSLMDQFAEVLFCLNKHCFTLLTVWLKEALRSPGFPSSRVSDEQKNTFSQQVLRERVNKRRVKDIVKEFTLVCRGLHGTEYAADY", "length": 953 }, "evidence": [ { "id": "A7YWD2", "url": "https://omabrowser.org/oma/group/A7YWD2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F4HNZ9-1", "protein_name": "ARM repeat superfamily protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MELQRKVAEAIHVLNHDPESSNRVAANQWLVQFQLTPAAWDVSTSLLTSPIVSLFDLQFFAAQILRRKIQNEASNLQSTAKDALLNALLLAAKRYSSGVPQLLTQICLALSALLLHSDPYSKPFDKLMFALQNLQAHDDGNVVLLELLTVLPEEISDTRHFSHHSDLRQELLSHTSMVLDFLLQQSENQFVSPLYPHDNNRKILRCLLSWVRAGCFSEIPQGAVPSHPLLNYVFNALQGTTFDLAIEVLVELVTRHEDLPQVLLYKVQFLRDTLLKPALINADLKIISGLACLMSEIGQAAPCLIVEASSEALILTDAILSCVTFPSEDWEIADSTVQFWSTFATYILSLGGNRQNDRTRVKDTFLPVFSALVDALVLRAQVDEFTSSDESPGLDLPDGLLHFRNNLLELLVDICQLLHPTTFVSKLFFGGVPSSSVSMPLREIEAKLFALTAVSEIILQEGEAFDFALIMQLVSAFSVRPSSELKGFISVVYRSLADVVGSYSRWISVFPSNARPLLLFLAGGISEPICSHACASALRKICEDAPAVIQETSNLDILMWIGECLEQWDLTLEDEEEVITAITVILGSVANKELQNKLLTQLLSSSYGVLSKLVDEDAESSGRQSPATYTRMLSSVTRGLYRIGTVFSHLATSLPSVPVADGPILSLLTVFWPILEKLFRSEHMESGSLAAAACRALSVAVQSSGEHFMLLLPSVLDCLSRNFLSFQSQECYIRTACVIAEEFCHKEEYGSLFITTFERFTQASSLMGINSSYICDQEPDLVEAYVNFASALIRSCHKELLGTSGTLLEISFHKAAICCTAMHRGAALAAMSYLSGFLEVSLSSMIETVNSISDGSFSVVSVQVVSHCGEGLLSNLVYALLGVAAMSRVHKCSTILQQLAAICSLCERTSWKGMLCWKSLQGWLNSAVWALPSEYLKQGEAESIVREWSEALGGAGIDYLENKSCNFGSNNSSGGHMQGKHGRTLKRLVRDFADSHRNDPNPNII", "length": 1005 }, "evidence": [ { "id": "A7YWD2", "url": "https://omabrowser.org/oma/group/A7YWD2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "G3HFG0-1", "protein_name": "Importin-13", "gene_name": "Ipo13", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MERREEQLGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCVVADMVRLFQAEDSPVDGQGRCLALLELLTVLPEEFQTSRLPQYRKGLVRASLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCEALIQAAFTALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLEEQLEQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWRSFLELVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQLYRPVYFKLVDVLLRKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLGHLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINNVLPLVLHALGNPELSVSSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDVSHHEDDHEGPELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEIESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFSLNKHCFSLLSMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY", "length": 963 }, "evidence": [ { "id": "A7YWD2", "url": "https://omabrowser.org/oma/group/A7YWD2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O94829-1", "protein_name": "Importin-13", "gene_name": "IPO13", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDGQGRCLALLELLTVLPEEFQTSRLPQYRKGLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSVSSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDISHHEDDHEGPELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEVESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY", "length": 963 }, "evidence": [ { "id": "A7YWD2", "url": "https://omabrowser.org/oma/group/A7YWD2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8K0C1-1", "protein_name": "Importin-13", "gene_name": "Ipo13", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERREEQLGAAGAGAAPALDFTVENVEKALHQLYYDPNIDNKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDSQGRCLALLELLTVLPEEFQTSRLPQYRKGLVRTSLAVECGTVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSVSSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDVSHHEDDHEGPELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTVPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLSLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEIESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY", "length": 963 }, "evidence": [ { "id": "A7YWD2", "url": "https://omabrowser.org/oma/group/A7YWD2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9JM04-1", "protein_name": "Importin-13", "gene_name": "Ipo13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MERREEQLGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAHSFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDSQGRCLALLELLTVLPEEFQTSRLPQYRKGLVRASLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSVSSVSTLKKICRECKYELPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEENLKNLHSLISTYIQQLEKLAEEIPKPSNKLAIVHILGLLSNLFTTLDVSHHEDDHEGPELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLSDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTVPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLSLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFQCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEIESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY", "length": 963 }, "evidence": [ { "id": "A7YWD2", "url": "https://omabrowser.org/oma/group/A7YWD2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9VEC5-1", "protein_name": "Importin-13", "gene_name": "cdm", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEPIDIARLEEAVVSFYRSNSQNQAITHEWLTDAEASPQAWQFSWQLMQLGKSQEVQFFGAITLHSKLMKHWHEVPPENREELKQKILESIVRFAGGPKIVLNRLCISLGAYIVHMLGEWPGAIEEVINTFQNQRMPNVSADVQLWIMLEVLTAIPEEAQVIHTSVKRVVLRAEIAKRVQLVIHTVERYLKLQMNRVWDAEAYSNMNRAVKCVGTWIKNIGYTIEGCVTITAVLLEVVHKCYWPCIHAGDGCMTADENELAESCLKTMVNIIIQPDCHNYPKTAFVLIKMFLDSLSEITKTEWKRENDNEDIIVHIYMLFVSSVERHSTLLLSGITSADPELSILVHRIVQEILHCTDKPGIYPVEESCSTMALAFWYMLQDEVFAMSNDEQKHKCWEYIKPLYAHLTRILVRKSEQPDEKSLAKWSSDDLECFRCYRQDISDTFMYCYDVLNDYILEILAAMLDEAIADLQRHPTHWTKLEACIYSFQSVAEHFGGEEKRQIPRLMRVLAEIPYEKLNVKLLGTALETMGSYCNWLMENPAYIPPAINLLVRGLNSSMSAQATLGLKELCRDCQLQLKPYADPLLNACHASLNTGRMKNSDSVRLMFSIGKLMSLLRPEEIPKYLDIIVSPCFEELQAICQADSKTPAARIRTIFRLNMISTLFSSLNTDVDEQATDQPIVQPVLLVMQRTMPIFKRIAEMWVEEIDVLEAACSAMKHAITNLRSSFQPMLQDLCLFIVASFQTRCCAPTLEISKTAIVMFFKDEGCKPLMQQLLREFIQHSFKLFESTPEQNFSNISDTMETFFGCLTQIIKKIPQVLEDKTLAYDRLVFYAQRGMTLPESGAIRNSIQFLTHFVMQSRNHAHVTEVVLATGEQTLYTAMMCVGYLTPRSQVDKFADILLAMNRKYAAEMAVWMKSLMSTPNFPTQLITDADKTRYTALIIKEKVNKRLLQQHLSEMAMKTRGLTEKFQ", "length": 971 }, "evidence": [ { "id": "A7YWD2", "url": "https://omabrowser.org/oma/group/A7YWD2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A7YWD2", "url": "https://www.uniprot.org/uniprotkb/A7YWD2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A7YWD2", "url": "https://www.uniprot.org/uniprotkb/A7YWD2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A7YWD2", "url": "https://www.uniprot.org/uniprotkb/A7YWD2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein import into nucleus", "id": "GO:0006606", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006606", "evidence": [ { "database": "UniProtKB", "id": "A7YWD2", "url": "https://www.uniprot.org/uniprotkb/A7YWD2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" }, { "start_pos": 353, "end_pos": 355, "annotation": "n_glycosylation_sequon" }, { "start_pos": 483, "end_pos": 485, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7YWD2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 963, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7YWD2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7YWD2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A7YWD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWD2" }, { "id": "PRU00115", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00115" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Importin N-terminal", "eco_id": "ECO_0000255", "start_pos": 45, "end_pos": 111, "start_aa": "Ala", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 318, "end_pos": 320 }, { "start_pos": 353, "end_pos": 355 }, { "start_pos": 483, "end_pos": 485 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": 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"publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BD46-1", "uniprot_ac": "E1BD46", "uniprot_id": "E1BD46_BOVIN", "mass": { "chemical_mass": 74796.0, "monoisotopic_mass": 74796.0 }, "refseq": { "ac": "XP_010800991", "name": "protein-arginine deiminase type-3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010800991" }, "gene_names": [ { "name": "PADI3", "type": "recommended", "evidence": [ { "id": "E1BD46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD46" } ] }, { "name": "PADI3", "type": "synonym", "evidence": [ { "id": "XP_010800991", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010800991" } ] } ], "protein_names": [ { "name": "Protein-arginine deiminase", "type": "recommended", "evidence": [ { "id": "E1BD46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD46/entry#names_and_taxonomy" } ] }, { "name": "3.5.3.15", "type": "synonym", "evidence": [ { "id": "E1BD46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD46/entry#names_and_taxonomy" } ] }, { "name": "protein-arginine deiminase type-3", "type": "synonym", "evidence": [ { "id": "XP_010800991", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010800991" } ] } ], "function": [ { "annotation": "Catalyzes the deimination of arginine residues of proteins.", "evidence": [ { "database": "UniProtKB", "id": "E1BD46", "url": "https://www.uniprot.org/uniprotkb/E1BD46#function" }, { "database": "UniProtKB", "id": "PIRNR001247", "url": "https://www.uniprot.org/uniprotkb/PIRNR001247#function" }, { "database": "UniProtKB", "id": "ARBA00057234", "url": "https://www.uniprot.org/uniprotkb/ARBA00057234#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BD46", "url": "https://www.uniprot.org/uniprotkb/E1BD46" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PADI3", "url": "https://www.uniprot.org/uniprotkb/E1BD46", "locus": { "chromosome": "2", "start_pos": 135316420, "end_pos": 135346451, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012043", "url": "https://www.ensembl.org/id/ENSBTAG00000012043" } ] } } ], "crossref": [ { "id": "E1BD46", "url": "https://alphafold.ebi.ac.uk/entry/E1BD46", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012043", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012043", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04214", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04214", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508160", "url": "https://www.ncbi.nlm.nih.gov/gene/508160", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004303", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004303", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013530", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013530", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013732", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013732", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013733", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013733", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036556", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036556", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038685", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038685", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508160", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508160", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QKCGHGR", "url": "https://omabrowser.org/oma/group/QKCGHGR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BD46", "url": "https://www.orthodb.org/?gene=E1BD46", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10837", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10837", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10837:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10837:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03068", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03068", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08526", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08526", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08527", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08527", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3247509", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3247509", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010800991", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010800991", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "18089", "url": "https://www.rhea-db.org/rhea/18089", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SFS3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFS3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFS3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD46", "url": "https://www.uniprot.org/uniprotkb/E1BD46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD46-1", "url": "https://www.uniprot.org/uniprotkb/E1BD46-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLQRIVRVSLEHPTSAVCVAGVETLVDIYGSVPEGTETFEVYGTPGVDIYICPNVERDRERADARRWHFDMGSQIIVVMNSPSNELNDSHVQISYHSSRDSSPLAYALLYLTCVDITLDCDLNCEGRQDRDFVDKRQWVWGPSGHGAILLVNCDRDSMSSDDQDNCDHHVRCLQDLEDMSVMILRTQGPNALFDDHKLVLHTSSADAERARVFHACGPGDSCEAYRHVLGQNKVSYEVHRFHGDEERFFVEGLSFPDAGFSGLVAFHVTLLDDSNEDFSESPIFTDTVVFRVAPWIMTPSTQPPLEVYVCRVKNNTCFVHAVAELARRAGCKLTVCPQAENRNDRWIQDEMELGYIQAPHKTFPVVFDSPRNGELQNFPYKRILGPDFGYVTREPQDNSVSGLDSFGNLEVSPPVVANGKEYPLGRILFGGNLPGSRGRRVTQVVRDFLHAQRVQPPVELFVDWLAVGHVDEFLSFVPVADGKGFRMLLASPSACLKLFQEKQKWGHGGALLFQGVAGNQEVNTVSISQVLSNGNLISYNKFVQSCIDWNREVLKRELGLAERDIVDIPQLFKMERRKAVAFFPDLVNMLVLGQHLGIPKPFGPVINGRCCLEEKVRSLLEPLGLHCTFIDDFTPYHMLHGEVHCGTNVRRQPFSFKWWHMEP", "length": 664, "header": "tr|E1BD46-1|E1BD46_BOVIN Isoform 1 of Protein-arginine deiminase OS=Bos taurus OX=9913 GN=PADI3 PE=3 SV=1 CANONICAL=E1BD46-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFS3-1", "url": "https://www.uniprot.org/uniprotkb/E1BD46/entry#A0AAA9SFS3-1", "sequence": { "sequence": "MHPPGVRFIIIAVFSLTFNSCRACAVGTVPNVPHFPALIRTTCHQSHGAIISAAPQWRRGRPGRTVTVLGVLCQPRPSDSGALHRLIHHAPCPLITRAGISWAFPTRSVFSMDCFKSELPSSDCRDLYKAHIAEEQTEAAQKCEGPRWRSQNPEVQISYHSSRDSSPLAYALLYLTCVDITLDCDLNCEGRQDRDFVDKRQWVWGPSGHGAILLVNCDRDSMSSDDQDNCDHHVRCLQDLEDMSVMILRTQGPNALFDDHKLVLHTSSADAERARVFHACGPGDSCEAYRHVLGQNKVSYEVHRFHGDEERFFVEGLSFPDAGFSGLVAFHVTLLDDSNEDFSESPIFTDTVVFRVAPWIMTPSTQPPLEVYVCRVKNNTCFVHAVAELARRAGCKLTVCPQAENRNDRWIQDEMELGYIQAPHKTFPVVFDSPRNGELQNFPYKRILGPDFGYVTREPQDNSVSGLDSFGNLEVSPPVVANGKEYPLGRILFGGNLPGSRGRRVTQVVRDFLHAQRVQPPVELFVDWLAVGHVDEFLSFVPVADGKGFRMLLASPSACLKLFQEKQKWGHGGALLFQGVAGNQEVNTVSISQVLSNGNLISYNKFVQSCIDWNREVLKRELGLAERDIVDIPQLFKMERRKAVAFFPDLVNMLVLGQHLGIPKPFGPVINGRCCLEEKVRSLLEPLGLHCTFIDDFTPYHMLHGEVHCGTNVRRQPFSFKWWHMEP", "length": 727, "header": "tr|A0AAA9SFS3-1|E1BD46_BOVIN Computationally mapped isoform of Protein-arginine deiminase OS=Bos taurus OX=9913 GN=PADI3 PE=3 SV=1 CANONICAL=E1BD46-1" }, "locus": { "chromosome": "2", "start_pos": 135337526, "end_pos": 135317424, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101397.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101397.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085032.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085032.1" } ] } }, { "isoform_ac": "A0AAA9SRH1-1", "url": "https://www.uniprot.org/uniprotkb/E1BD46/entry#A0AAA9SRH1-1", "sequence": { "sequence": "MEKERQRRLKEELGWWLHRGSWEHLPSLPDPPRPVLWGQAPSFSQLDPGPISPQVQISYHSSRDSSPLAYALLYLTCVDITLDCDLNCEGRQDRDFVDKRQWVWGPSGHGAILLVNCDRDSMSSDDQDNCDHHVRCLQDLEDMSVMILRTQGPNALFDDHKLVLHTSSADAERARVFHACGPGDSCEAYRHVLGQNKVSYEVHRFHGDEERFFVEGLSFPDAGFSGLVAFHVTLLDDSNEDFSESPIFTDTVVFRVAPWIMTPSTQPPLEVYVCRVKNNTCFVHAVAELARRAGCKLTVCPQAENRNDRWIQDEMELGYIQAPHKTFPVVFDSPRNGELQNFPYKRILGPDFGYVTREPQDNSVSGLDSFGNLEVSPPVVANGKEYPLGRILFGGNLPGSRGRRVTQVVRDFLHAQRVQPPVELFVDWLAVGHVDEFLSFVPVADGKGFRMLLASPSACLKLFQEKQKWGHGGALLFQGVAGNQEVNTVSISQVLSNGNLISYNKFVQSCIDWNREVLKRELGLAERDIVDIPQLFKMERRKAVAFFPDLVNMLVLGQHLGIPKPFGPVINGRCCLEEKVRSLLEPLGLHCTFIDDFTPYHMLHGEVHCGTNVRRQPFSFKWWHMEP", "length": 627, "header": "tr|A0AAA9SRH1-1|E1BD46_BOVIN Computationally mapped isoform of Protein-arginine deiminase OS=Bos taurus OX=9913 GN=PADI3 PE=3 SV=1 CANONICAL=E1BD46-1" }, "locus": { "chromosome": "2", "start_pos": 135336769, "end_pos": 135317424, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118553.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118553.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087948.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087948.1" } ] } }, { "isoform_ac": "E1BD46-1", "url": "https://www.uniprot.org/uniprotkb/E1BD46/entry#E1BD46-1", "sequence": { "sequence": "MSLQRIVRVSLEHPTSAVCVAGVETLVDIYGSVPEGTETFEVYGTPGVDIYICPNVERDRERADARRWHFDMGSQIIVVMNSPSNELNDSHVQISYHSSRDSSPLAYALLYLTCVDITLDCDLNCEGRQDRDFVDKRQWVWGPSGHGAILLVNCDRDSMSSDDQDNCDHHVRCLQDLEDMSVMILRTQGPNALFDDHKLVLHTSSADAERARVFHACGPGDSCEAYRHVLGQNKVSYEVHRFHGDEERFFVEGLSFPDAGFSGLVAFHVTLLDDSNEDFSESPIFTDTVVFRVAPWIMTPSTQPPLEVYVCRVKNNTCFVHAVAELARRAGCKLTVCPQAENRNDRWIQDEMELGYIQAPHKTFPVVFDSPRNGELQNFPYKRILGPDFGYVTREPQDNSVSGLDSFGNLEVSPPVVANGKEYPLGRILFGGNLPGSRGRRVTQVVRDFLHAQRVQPPVELFVDWLAVGHVDEFLSFVPVADGKGFRMLLASPSACLKLFQEKQKWGHGGALLFQGVAGNQEVNTVSISQVLSNGNLISYNKFVQSCIDWNREVLKRELGLAERDIVDIPQLFKMERRKAVAFFPDLVNMLVLGQHLGIPKPFGPVINGRCCLEEKVRSLLEPLGLHCTFIDDFTPYHMLHGEVHCGTNVRRQPFSFKWWHMEP", "length": 664, "header": "tr|E1BD46-1|E1BD46_BOVIN Isoform 1 of Protein-arginine deiminase OS=Bos taurus OX=9913 GN=PADI3 PE=3 SV=1 CANONICAL=E1BD46-1" }, "locus": { "chromosome": "2", "start_pos": 135346252, "end_pos": 135317424, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015978.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015978.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015978.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015978.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:508160", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508160", "resource": "KEGG Pathway" }, { "id": "R-BTA-3247509", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3247509", "resource": "Reactome", "description": "Chromatin modifying enzymes" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2M457-1", "protein_name": "Protein-arginine deiminase", "gene_name": "Padi3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSLQRIVRVSLEHPTSAVCVAGVETIVDIYGSVPEGTAMFEVYGTPGVDIYVSTSMERNRERADTRRWCFNEGLEIIVVMKSPSNHLNDSHIQIAYHSSHEQLPLAYAVLYLTCVDITLDCDVNCEGRQDRSFVDKSQWVWGPDGYGAILLVNCDRDDVGCDAQDNCDQHVSCLKDLEDMSIMVLRTQGPEALFDDHKLILHTSSCDAERARVFHVCGPEDSCEAYKCVLGPDRVSYEVPRLNGHEERFFVEGLSFPDAGFPGLISFHITLLDDSNEDFSETPIFTDTVVFRVAPWIMTPSTLPPLEVYVCRVRNNMCFVEAVEELARKAGCKLTICPQAENRNDRWIQDEMELGYVQAPHKTMPVVFDSPRNGELQGFPYKRILGLDFGYVTREPRDSSVSGLDSFGNLEVSPPVVANGKEYPLGRILIGGNLPGSRGRRVTRVVRDFLRAQKVQPLVELFVDWLAVGHVDEFLSFVPAPDRKGFRLLLASPSACFRLFQEKQKWGHGRSLLFEGVIGDRRVKTISINQVLSNQNLINFNKFAQSCIDWNREVLKRELGLADCDIIDIPQLFKTERRKAVAFFPDLVNMLVLGRYLGIPKPFGPIINGRCCLEEKVRSLLEPLGLHCTFIDDFTPYHMLHGEVHCGTNVRREPFAFKWWHMVP", "length": 664 }, "evidence": [ { "id": "E1BD46", "url": "https://omabrowser.org/oma/group/E1BD46/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1SUR1-1", "protein_name": "Protein-arginine deiminase", "gene_name": "PADI3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLQRIVRVSLEHPTSAVCVAGVETLVDIYGSVPEGTEMFEIYGTPGVDIYISTSRERARERADTRRWRFDQGSEIIVVMNSPSNDLNDSHVQISYHSSHEPLPLGYAVLYLTCVDIALDCDLNYAGRQDRGFVDKRQWVWGPEGYGAILLVNCDRDNLNSDKQDNCDRHVHCLQDLEDMSVMVLRTQGPAALFDDHKLVLHASSSDAKRARVFHACGPEDSCEAYRHVLGQDKLAYEVPHFHGDEEHFFVEGLSFPDAGFSGLISFHVTLLDDSNEDFSESPIFTDTVVFRVAPWIMTPSTLPPLEVYVCRVKNNTGFVDAVAELARRAGCKLTICPQDENRNDRWIQDEMELGYVQAPHKTFPVVFDSPRNGKLQDFPFKRILGPDFGYVTREPRDNSVSGLDSFGNLEVSPPVAANGKEYPLGRILIGGHLPGSRGRRVTPVVRNFLHAQKVQPPVELFVDWLSVGHVDEFLSFVPAPDGKGFRMLLASPSACFKLFQEKQKWGHGSALLFQGVAGTQNVNTISLNQVLSSGSLISYNKFVQSCIDWNREVLKRELGLTEGDIIDIPQLFKTEKRKAVAFFPDLVNMLVLGKHLGIPKPFGPIINGRCCLEEKVRSLLEPLGLHCTFIDDFTPYHMLHGEVHCGTNVRRQPFSFKWWHMLP", "length": 664 }, "evidence": [ { "id": "E1BD46", "url": "https://omabrowser.org/oma/group/E1BD46/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P70708-1", "protein_name": "Protein-arginine deiminase type-3", "gene_name": "Padi3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLQRTVRVSLEHPTSAVCVAGVETIVDIYGSVPEGTDMFEVYGTPGVDIYVSPSMERNRERADTRRWCFNKGLEIIVVMNSPSNDLNDSHVQIAYHSSHEHLPLAYAVLYLTCVDITLDCDMNCADRQDRSFVDKRQWMWGPDGYGAILLVNCDRDEVSSDAQDNCDQCVRCLQDLEDMSVMVLRTQGPESLFDDHRLILHTSSCDAERARVFHVCGPEDSCEAYRCVLGPDRMSYEVPRLKGYEERFYVEGLSFPDAGFPGILSFHITLLDDSNEDYSETPIFTDTVVFRVAPWIMTPSTLPPLEVYVCQVRNNTCFVEAVEELARKAGCKLTICPQAENRNDRWIQDEMELGYTQAPHKTLPVVFDSPRNGELQGFPYKRILGLDFGYVTREPPDSSVSGLDSFGNLEVSPPVVANGKEYPLGRILIGGNLPGSRGRRVTQVVRDFLHAQKVQPLVELFVDWLAVGHVDEFLSFVPAPDGKGFRLLLASPGACFRLFQEKQKWGHGRSLLFEGVIGDRRVQTISINQVLSNQSLINFNKFAQSCIDWNREVLKRELGLGESDIIDIPQLFKSEKRKAVAFFPDLVNMLVLGKHLGIPKPFGPIINGRCCLEEKVRSLLEPLGLHCTFIDDFTPYHMLHGEVHCGTNVRREPFAFKWWHMVP", "length": 664 }, "evidence": [ { "id": "E1BD46", "url": "https://omabrowser.org/oma/group/E1BD46/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9ULW8-1", "protein_name": "Protein-arginine deiminase type-3", "gene_name": "PADI3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLQRIVRVSLEHPTSAVCVAGVETLVDIYGSVPEGTEMFEVYGTPGVDIYISPNMERGRERADTRRWRFDATLEIIVVMNSPSNDLNDSHVQISYHSSHEPLPLAYAVLYLTCVDISLDCDLNCEGRQDRNFVDKRQWVWGPSGYGGILLVNCDRDDPSCDVQDNCDQHVHCLQDLEDMSVMVLRTQGPAALFDDHKLVLHTSSYDAKRAQVFHICGPEDVCEAYRHVLGQDKVSYEVPRLHGDEERFFVEGLSFPDAGFTGLISFHVTLLDDSNEDFSASPIFTDTVVFRVAPWIMTPSTLPPLEVYVCRVRNNTCFVDAVAELARKAGCKLTICPQAENRNDRWIQDEMELGYVQAPHKTLPVVFDSPRNGELQDFPYKRILGPDFGYVTREPRDRSVSGLDSFGNLEVSPPVVANGKEYPLGRILIGGNLPGSSGRRVTQVVRDFLHAQKVQPPVELFVDWLAVGHVDEFLSFVPAPDGKGFRMLLASPGACFKLFQEKQKCGHGRALLFQGVVDDEQVKTISINQVLSNKDLINYNKFVQSCIDWNREVLKRELGLAECDIIDIPQLFKTERKKATAFFPDLVNMLVLGKHLGIPKPFGPIINGCCCLEEKVRSLLEPLGLHCTFIDDFTPYHMLHGEVHCGTNVCRKPFSFKWWNMVP", "length": 664 }, "evidence": [ { "id": "E1BD46", "url": "https://omabrowser.org/oma/group/E1BD46/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z184-1", "protein_name": "Protein-arginine deiminase type-3", "gene_name": "Padi3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLQRIVRVSLEHPTSAVCVAGVETIVDIYGAVPEGTDMFEVYGTPGVDIYVSPSMERSRERADTRRWCFNKGLEIIVIMNSPSNDLNDSHVQIAYHSSREHLPLAYAVLYLTCVDITLDCDMNCADRQDRSFVDKRQWVWGPDGYGAILLVNCDRDNVDSNAQDNCDQYVRCLQDLEDMSVMVLRTQGPEALFEDHRLILHTSSCDAERARVFHVCGPEDSCESYKCVLGPDRMSYEVPRLKGYEERFFVEGLSFPDAGFPGLISFHVTLLDDSNEDFSETPIFTDTAVFRVAPWIMTPSTLPPLEVYVCRVRNNTCFVEAVEELARKAGCKLTICPQAENRNDRWIQDEMELGYVQAPHKTLPVVFDSPRNGELQGFPYKRILGLDFGYVTREPKDSSVSGLDSFGNLEVSPPVVANGKEYPLGRILIGGNLPGSRGRRVTQVVRNFLHAQKVQPLVELFVDWLAVGHVDEFLSFVPAPDGKGFRLLLASPGACFRLFQEKQKWGHGRSLLFEGVIGDRRVQTVSINQILNNQSLINFNKFAQSCIDWNREVLKRELGLAEGDIIDIPQLFKTEKRKAVAFFPDLVNMLVLGKHLGIPKPFGPIINGRCCLEEKVRSLLEPLGLHCTFIDDFTPYHMLHGEVHCGTNVRREPFAFKWWHMVP", "length": 664 }, "evidence": [ { "id": "E1BD46", "url": "https://omabrowser.org/oma/group/E1BD46/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein-arginine deiminase activity", "id": "GO:0004668", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004668", "evidence": [ { "database": "UniProtKB", "id": "E1BD46", "url": "https://www.uniprot.org/uniprotkb/E1BD46" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BD46", "url": "https://www.uniprot.org/uniprotkb/E1BD46" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "E1BD46", "url": "https://www.uniprot.org/uniprotkb/E1BD46" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BD46", "url": "https://www.uniprot.org/uniprotkb/E1BD46" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BD46", "url": "https://www.uniprot.org/uniprotkb/E1BD46" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BD46", "url": "https://www.uniprot.org/uniprotkb/E1BD46" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 315, "end_pos": 317, "annotation": "n_glycosylation_sequon" }, { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "18089", "name": "", "equation": "L-arginyl-[protein] + H2O = L-citrullyl-[protein] + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BD46-1", "E1BCN3-1", "A0AAA9TGP5-1", "A0ABI0NS39-1" ], "evidence": [ { "id": "18089", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/18089" } ] }, { "id": "R-BTA-1183128", "name": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-1183111" ], "output_participant_list": [ "R-ALL-1183191" ], "enzyme_list": [ "E1BCN3-1", "E1BD46-1" ], "evidence": [ { "id": "R-BTA-1183128", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1183128" } ] }, { "id": "R-BTA-3247569", "name": "PADI4 deiminates Histones", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BCN3-1", "E1BD46-1" ], "evidence": [ { "id": "R-BTA-3247569", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3247569" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1183111", "participant_name": "Protein-L-arginine [cytosol]", "crossref": [ { "id": "33708", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1183191", "participant_name": "Protein-L-citrulline [cytosol]", "crossref": [ { "id": "33708", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9TGP5", "gene_name": "PADI6", "activity": [ { "ec_number": "3.5.3.15", "activity": "L-arginyl-[protein] + H2O = L-citrullyl-[protein] + NH4(+).", "evidence": [ { "id": "A0AAA9TGP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP5" } ] }, { "ec_number": "3.5.3.15", "activity": "", "evidence": [ { "id": "A0AAA9TGP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP5" } ] } ] }, { "uniprot_ac": "A0ABI0NS39", "gene_name": "PADI2", "activity": [ { "ec_number": "3.5.3.15", "activity": "L-arginyl-[protein] + H2O = L-citrullyl-[protein] + NH4(+).", "evidence": [ { "id": "A0ABI0NS39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS39" } ] }, { "ec_number": "3.5.3.15", "activity": "", "evidence": [ { "id": "A0ABI0NS39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS39" } ] } ] }, { "uniprot_ac": "E1BCN3", "gene_name": "PADI4", "activity": [ { "ec_number": "3.5.3.15", "activity": "L-arginyl-[protein] + H2O = L-citrullyl-[protein] + NH4(+).", "evidence": [ { "id": "E1BCN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCN3" } ] }, { "ec_number": "3.5.3.15", "activity": "", "evidence": [ { "id": "E1BCN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCN3" } ] } ] }, { "uniprot_ac": "E1BD46", "gene_name": "PADI3", "activity": [ { "ec_number": "3.5.3.15", "activity": "L-arginyl-[protein] + H2O = L-citrullyl-[protein] + NH4(+).", "evidence": [ { "id": "E1BD46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD46" } ] }, { "ec_number": "3.5.3.15", "activity": "", "evidence": [ { "id": "E1BD46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD46" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BD46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD46" }, { "id": "PF08526", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08526" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein-arginine deiminase (PAD) N-terminal", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 113, "start_aa": "Met", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BD46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD46" }, { "id": "PF08527", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08527" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein-arginine deiminase (PAD) central", "eco_id": "ECO_0000259", "start_pos": 115, "end_pos": 273, "start_aa": "Val", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BD46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD46" }, { "id": "PF03068", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03068" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein-arginine deiminase C-terminal", "eco_id": "ECO_0000259", "start_pos": 284, "end_pos": 661, "start_aa": "Ile", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.5.3.15", "ec_name": "L-arginyl-[protein] + H2O = L-citrullyl-[protein] + NH4(+).", "evidence": [ { "id": "3.5.3.15", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15" }, { "id": "3.5.3.15", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.5.3.15" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 315, "end_pos": 317 }, { "start_pos": 88, "end_pos": 90 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDN4-1", "uniprot_ac": "E1BDN4", "uniprot_id": "E1BDN4_BOVIN", "mass": { "chemical_mass": 78874.0, "monoisotopic_mass": 78874.0 }, "refseq": { "ac": "NP_001179272", "name": "probable ATP-dependent RNA helicase DHX35", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179272" }, "gene_names": [ { "name": "DHX35", "type": "recommended", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "name": "DHX35", "type": "synonym", "evidence": [ { "id": "NP_001179272", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179272" } ] } ], "protein_names": [ { "name": "Probable ATP-dependent RNA helicase DHX35", "type": "recommended", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4/entry#names_and_taxonomy" } ] }, { "name": "3.6.4.13", "type": "synonym", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4/entry#names_and_taxonomy" } ] }, { "name": "DEAH (Asp-Glu-Ala-His) box polypeptide 35", "type": "synonym", "evidence": [ { "id": "NP_001179272", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179272" } ] }, { "name": "DEAH box protein 35", "type": "synonym", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4/entry#names_and_taxonomy" } ] }, { "name": "probable ATP-dependent RNA helicase DHX35", "type": "synonym", "evidence": [ { "id": "NP_001179272", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179272" } ] } ], "function": [ { "annotation": "May be involved in pre-mRNA splicing.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LMR8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMR8#function" }, { "database": "UniProtKB", "id": "ARBA00058987", "url": "https://www.uniprot.org/uniprotkb/ARBA00058987#function" }, { "database": "UniProtKB", "id": "E1BDN4", "url": "https://www.uniprot.org/uniprotkb/E1BDN4#function" }, { "database": "UniProtKB", "id": "A0A3Q1MBV1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBV1#function" }, { "database": "UniProtKB", "id": "A0AAA9SQM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDN4", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DHX35", "url": "https://www.uniprot.org/uniprotkb/E1BDN4", "locus": { "chromosome": "13", "start_pos": 67808169, "end_pos": 67739036, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004039", "url": "https://www.ensembl.org/id/ENSBTAG00000004039" } ] } } ], "crossref": [ { "id": "E1BDN4", "url": "https://alphafold.ebi.ac.uk/entry/E1BDN4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004039", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004039", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17980", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17980", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18791", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18791", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513148", "url": "https://www.ncbi.nlm.nih.gov/gene/513148", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011709", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513148", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513148", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FHEVMET", "url": "https://omabrowser.org/oma/group/FHEVMET/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LMR8", "url": "https://www.orthodb.org/?gene=A0A3Q1LMR8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MBV1", "url": "https://www.orthodb.org/?gene=A0A3Q1MBV1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BDN4", "url": "https://www.orthodb.org/?gene=E1BDN4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18934", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18934", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18934:SF136", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18934:SF136", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04408", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04408", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07717", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07717", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179272", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LMR8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMR8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMR8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBV1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBV1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBV1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQM0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDN4", "url": "https://www.uniprot.org/uniprotkb/E1BDN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDN4-1", "url": "https://www.uniprot.org/uniprotkb/E1BDN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSATTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIIGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTNPLATRIKFLTDGMLVREMMVDPLLTKYSAIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNHNDTSDPTRDTCVILTVEGRTFPVDIFYLQSPVPDYIKSTVETVMKIHQTEGDGDILAFLTGQEEVETVVSMLIEQARALGQTGMKRHLRILPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDQLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFVVPSNQKSQAIRAHRKFAVEEGDHLTMLNVYEAFIKHNKNSQWCQEHFLNYKGLVRAATVREQLKKLLVKFQVPKKSSEGDPDPVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQQGTHLSLRAKRAKVQDQ", "length": 703, "header": "tr|E1BDN4-1|E1BDN4_BOVIN Isoform 1 of Probable ATP-dependent RNA helicase DHX35 OS=Bos taurus OX=9913 GN=DHX35 PE=3 SV=1 CANONICAL=E1BDN4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LMR8-1", "url": "https://www.uniprot.org/uniprotkb/E1BDN4/entry#A0A3Q1LMR8-1", "sequence": { "sequence": "MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSATTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIIGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTNPLATRIKFLTDGMLVREMMVDPLLTKYSAIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNHNDTSDPTRDTCVILTVEGRTFPVDIFYLQSPVPDYIKSTVETVMKIHQTEGDGDILAFLTGQEEVETVVSMLIEQARALGQTGMKRHLRILPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDQLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFVVPSNQKSQAIRAHRKFAVEEGDHLTMLNVYEAFIKHNKNSQWCQEHFLNYKGLVRAATVREQLKKLLVKFQVPKKSSEGDPDPVLRCIVSGFFANAARFHSTGAYRVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQQGTHLSLRAKRAKVQDQ", "length": 679, "header": "tr|A0A3Q1LMR8-1|E1BDN4_BOVIN Computationally mapped isoform of Probable ATP-dependent RNA helicase DHX35 OS=Bos taurus OX=9913 GN=DHX35 PE=3 SV=2 CANONICAL=E1BDN4-1" }, "locus": { "chromosome": "13", "start_pos": 67807846, "end_pos": 67739235, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078654.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078654.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058024.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058024.2" } ] } }, { "isoform_ac": "A0A3Q1MBV1-1", "url": "https://www.uniprot.org/uniprotkb/E1BDN4/entry#A0A3Q1MBV1-1", "sequence": { "sequence": "MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSATTVVYNPYAALSIEQQRQKLPVFKYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTNPLATRIKFLTDGMLVREMMVDPLLTKYSAIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNHNDTSDPTRDTCVILTVEGRTFPVDIFYLQSPVPDYIKSTVETVMKIHQTEGDGDILAFLTGQEEVETVVSMLIEQARALGQTGMKRHLRILPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDQLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFVVPSNQKSQAIRAHRKFAVEEGDHLTMLNVYEAFIKHNKNSQWCQEHFLNYKGLVRAATVREQLKKLLVKFQVPKKSSEGDPDPVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQQGTHLSLRAKRAKVQDQ", "length": 672, "header": "tr|A0A3Q1MBV1-1|E1BDN4_BOVIN Computationally mapped isoform of Probable ATP-dependent RNA helicase DHX35 OS=Bos taurus OX=9913 GN=DHX35 PE=3 SV=2 CANONICAL=E1BDN4-1" }, "locus": { "chromosome": "13", "start_pos": 67807846, "end_pos": 67739235, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082211.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082211.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071571.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071571.2" } ] } }, { "isoform_ac": "A0AAA9SQM0-1", "url": "https://www.uniprot.org/uniprotkb/E1BDN4/entry#A0AAA9SQM0-1", "sequence": { "sequence": "MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSATTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIIGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTNPLATRIKFLTDGMLVREMMVDPLLTKYSAIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNHNDTSDPTRDTCVILTVEGRTFPVDIFYLQSPVPDYIKSTVETVMKIHQTEGDGDILAFLTGQEEVETVVSMLIEQARALGQTGMKRHLRILPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDQLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFVVPSNQKSQAIRAHRKFAVEEGDHLTMLNVYEAFIKHNKNSQWCQEHFLNYKGLVRAATVREQLKKLLVKFQVPKKSSEGDPDPVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQQGTVSSSPAPKTWTFDVSTGCLGCSVRPLHSGCAELQCLQHCADLQNLLCTRSQLPSSCSLPALWTLGLHLCGLVFSQRFKSGSSVLISGAPLF", "length": 780, "header": "tr|A0AAA9SQM0-1|E1BDN4_BOVIN Computationally mapped isoform of Probable ATP-dependent RNA helicase DHX35 OS=Bos taurus OX=9913 GN=DHX35 PE=3 SV=1 CANONICAL=E1BDN4-1" }, "locus": { "chromosome": "13", "start_pos": 67804351, "end_pos": 67739235, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112297.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112297.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086238.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086238.1" } ] } }, { "isoform_ac": "E1BDN4-1", "url": "https://www.uniprot.org/uniprotkb/E1BDN4/entry#E1BDN4-1", "sequence": { "sequence": "MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSATTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIIGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTNPLATRIKFLTDGMLVREMMVDPLLTKYSAIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNHNDTSDPTRDTCVILTVEGRTFPVDIFYLQSPVPDYIKSTVETVMKIHQTEGDGDILAFLTGQEEVETVVSMLIEQARALGQTGMKRHLRILPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDQLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFVVPSNQKSQAIRAHRKFAVEEGDHLTMLNVYEAFIKHNKNSQWCQEHFLNYKGLVRAATVREQLKKLLVKFQVPKKSSEGDPDPVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQQGTHLSLRAKRAKVQDQ", "length": 703, "header": "tr|E1BDN4-1|E1BDN4_BOVIN Isoform 1 of Probable ATP-dependent RNA helicase DHX35 OS=Bos taurus OX=9913 GN=DHX35 PE=3 SV=1 CANONICAL=E1BDN4-1" }, "locus": { "chromosome": "13", "start_pos": 67807846, "end_pos": 67739235, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005281.8", "url": "https://www.ensembl.org/id/ENSBTAT00000005281.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005281.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005281.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 115, "start_aa": "Thr", "end_pos": 115, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr115", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:513148", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513148", "resource": "KEGG Pathway" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JTM6-1", "protein_name": "Probable ATP-dependent RNA helicase DHX35", "gene_name": "Dhx35", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAPLGPVKFWKPGTEGPGVSISEERQSVTENSGTTVIYNPYAALSIEQQRQKLPVFKLRNHILYLVENYQTVVIVGETGCGKSTQVPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVADERGAVLGHEVGYCIRFDDCTDPLATRIKFLTDGMLVREMMVDPLLTKYSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQNETSDPARDTCVILTVEGRTFPVDIFYLQSPVPDYIKATVDTVVKIHQTEGDGDILAFLTGQEEVETVVSMLIEQARALARTGMKKHLRVLPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRNRSGKCYRLYTEEAFEQLPQSTVPEMQRSNLAPVVLQLKALGIDSVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNVFVFPSNQKSQATRVHRKFAVEEGDHLTMLNVYEAFIKHNKSSQWCQEHFLNYKGLVRAATVRDQLKKLLVKFQVPKMSSEGDPDPVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQQGTHLSLKAKRAKVQDQ", "length": 703 }, "evidence": [ { "id": "E1BDN4", "url": "https://omabrowser.org/oma/group/E1BDN4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0ZWH7-1", "protein_name": "Probable ATP-dependent RNA helicase DHX35", "gene_name": "DHX35", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAPVGPVKFWKPGTEGPGVSVSEERQSPAESSGVTVVYNPYASLSIEQQRQKLPVFKLRNHILYLVESYQTLVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVSVAGRVADERGAVLGHEVGYCIRFDDCTDPQATRIKFLTDGMLVREMMADPLLTRYSVLMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQNDTGDPSKDTSVILTVEGRTFPVDIFYIQSPVPDYIKSTVETAMKIHQMENDGDILAFLTGQEEVETVVSMLIEQARALSRTGMRKHLRVLPMYAGLPSPDQMKVFERVSRSVRKVIVATNVAETSITIHGIAYVIDCGFVKLRAYNPKTAIECLVVVPVSKASANQRAGRAGRNRSGKCYRLYTEEDFEKLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFPFLSPPPAQSMVQALELLYALGGLDMHCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILTIAAMMQIQNIFLIPPNQKSQAARQHRKFAVEEGDHLTMLNVYEAFVKHSKSSQWCQEHFLNYKGLVRASVVREQLKKLLVRFKVPKKSSEGDPDPVLRCIVSGFFANAAKFHSTGAYRTIRDDHELHIHPTSVLYAEKPPRWVVYNEVIQTAKYYMRDVTAIESAWLVELAPHFYQQGTHLSLNAKRAKVDDH", "length": 703 }, "evidence": [ { "id": "E1BDN4", "url": "https://omabrowser.org/oma/group/E1BDN4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A2ACQ1-1", "protein_name": "Probable ATP-dependent RNA helicase DHX35", "gene_name": "Dhx35", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAPLGPVKFWKPGTEGPGVSISEERQSVTENSGTTIIYNPYAALSIEQQRQKLPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVADERGAVLGHEVGYCIRFDDCTDPLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQNETSDPARDTSVTLTVEGRTFPVDIFYLQSPVPDYIKATVDTVVKIHQTEGDGDILAFLTGQEEVETVVSMLIEQARALARTGMKKHLRVLPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRNRSGKCYRLYTEEAFDQLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEVLSIAAMMQIQNVFVFPSNQKSQATRVHRKFAVEEGDHLTMLNVYEAFIKHNKSSQWCQEHFLNYKGLVRAATVRDQLKKLLVKFQVPKVSSEGDPDPVLRCIVSGFFANAARFHSSGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQQGTHLSLKAKRAKVQDQ", "length": 703 }, "evidence": [ { "id": "E1BDN4", "url": "https://omabrowser.org/oma/group/E1BDN4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F4JRJ6-1", "protein_name": "Probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH9", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAFWKPGTEKPRFEEDGEGGIVFMSNNLASSSSSSYGYANIEKQRQRLPVYKYRTEILYLVENHATTIIVGETGSGKTTQIPQYLKEAGWAEGGRVIACTQPRRLAVQAVSARVAEEMGVNLGEEVGYTIRFEDHTTSGVTSVKFLTDGVLIREMMEDPLLTKYSVIMIDEAHERSISTDILLGLLKKIQRRRPELRLIISSATIEAKTMSNFFNSSKKRHAPEGSTPGPKLEPAILSVEGRGFSVKIHYVEEPVSDYIRSVVSTILLINEREPPGDVLVFLTGQEDIETAIKLLEEEAHSNQKNSSGLLPLPLYSGLSRSEQELIFTPTPRGKRKVILSTNIAETSLTLEGVVYVIDSGFSKQKFYNPISDIESLVVAPISKASARQRSGRAGRVRPGKCYRLYTEDYFLNQMPGEGIPEMQRSNLVSTVIQLKALGIDNILGFDWPAPPSSEAMIRALEVLYSLQILDDDAKLTSPTGFQVAELPLDPMISKMILASSELGCSHEIITIAAVLSVQSVWIIARGVQKEQDEAKLRFAAAEGDHVTFLNVYKGFLESKKPTQWCYKNFLNYQSMKKVVEIRDQLKRIARRLGITLKSCDGDMEAVRKAVTAGFFANACRLEPHSNGVYKTIRGSEEVYIHPSSVLFRVNPKWVVYQSIVSTERQYMRNVVTINPSWLTEVAPHFYQNRQNAMSF", "length": 695 }, "evidence": [ { "id": "E1BDN4", "url": "https://omabrowser.org/oma/group/E1BDN4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q55EC3-1", "protein_name": "RNA helicase", "gene_name": "dhx35", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MATNNQINNNSSNNNNNNNNNNSLFDKDSSLSFGNDNFIYNSNQKLTIQQQRISLPIYQNRKHILYLLEKYSTLVIIGNTGCGKSTQIPQYLFESGWSDGFRTILCTQPRRVAAISLAERVAQEMGEQHVGKTVGYSVRFDEKISDIETRIKYVTDGMLIREMMLDPLLLKYSVIMIDEAHERSLQTDLLMGLLKKVQKKRNSTNNNNNNDNSLKLIISSATLNANDFFNFFNYNQTNDKSKDTSTILSIEGRTYPVDIHYLEESTSNYIQTTIQTIIDIHTTQPPGDILVFLTGQEEIEKLIQTLDDKFEILRQYHQQHHHQQQQPFMKYSLLPMYSGLSINKQIKVFESVGDSKKIRKIIISTNIAETSITIDGVVYVVDCGFVKIKSYDSESGLESLVIVPTSKSSANQRAGRAGRSRAGKCYRLYTELTYEKLLPDQTIPEIQRSNLTNTILQLKALGIDNILNFDFISQPPSSSLIRGLEVLYGLGALDDNGKLTNPTGMIMAEFPTDPTFSKMIIQSSSNGFNCSDECITITAMLNIQGLFTNQNHKSRKHLLVKEGDHLTLLNIFNSFISNQSSPQWCNQHQINYKAMQRVLQVRKQLLAYAKKYSINVISCFDSNNNREQCSNLIRKAIVSGFFTNAAQLQPDGSYQTIREKHKLWLHPTSVLCLSNSPQWVIFNEVTITTKEYMKDVTSIEPNWLFEIAPHYYKFKK", "length": 716 }, "evidence": [ { "id": "E1BDN4", "url": "https://omabrowser.org/oma/group/E1BDN4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9H5Z1-1", "protein_name": "Probable ATP-dependent RNA helicase DHX35", "gene_name": "DHX35", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAPVGPVKFWRPGTEGPGVSISEERQSLAENSGTTVVYNPYAALSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQNETSDPARDTCVILTVEGRTFPVDIFYLQSPVPDYIKSTVETVVKIHQTEGDGDVLAFLTGQEEVETVVSMLIEQARALARTGMKRHLRVLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFVVPPNQKSHAIRVHRKFAVEEGDHLTMLNIYEAFIKHNKDSKWCQEHFLNYKGLVRAATVREQLKKLLVKFQVPRKSSEGDPDLVLRCIVSGFFANAARFHSTGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAPHFYQQGTHLSLKAKRAKVQDP", "length": 703 }, "evidence": [ { "id": "E1BDN4", "url": "https://omabrowser.org/oma/group/E1BDN4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VR29-1", "protein_name": "RNA helicase", "gene_name": "cg3225", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSTFKPKFLKPETDDAITDSAGGEQQSSAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVGETGSGKSTQVPQYLYEWGWHTKGLIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSCTKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATIDASFFSEFFSWPGSGEVSVKLSIEGRMHPVSNFYLNEPCADYVKETVETVWKLHQKEPPGDILAFLTGQEEVLEALDLLREYIASSEQENLKVLPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPRQPPEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAIDEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRIAHRKFEVAEGDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLITVARKKYGIPIFSCKGDVEKLCKCITAGFFTQVAYLHHSGVYRQISSGTELAIHPNSTLYTLPQAQYVVYGELLQTTKLFMNYVTVIKREWLTELAPHYYQQTTVRD", "length": 678 }, "evidence": [ { "id": "E1BDN4", "url": "https://omabrowser.org/oma/group/E1BDN4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1BDN4", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "E1BDN4", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "database": "UniProtKB", "id": "E1BDN4", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BDN4", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ], "pmid": "" }, { "name": "helicase activity", "id": "GO:0004386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004386", "evidence": [ { "database": "UniProtKB", "id": "E1BDN4", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "E1BDN4", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "E1BDN4", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "catalytic step 2 spliceosome", "id": "GO:0071013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071013", "evidence": [ { "database": "UniProtKB", "id": "E1BDN4", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 223, "end_pos": 225, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] }, { "id": "R-BTA-9770141", "name": "Formation of the Spliceosomal C* complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-5688092", "R-BTA-5688093", "R-BTA-72073", "R-BTA-9769591", "R-BTA-9769593", "R-BTA-9769594", "R-BTA-9769596", "R-BTA-9769598", "R-BTA-9769599", "R-BTA-9769601" ], "output_participant_list": [ "R-BTA-72060", "R-BTA-8867898", "R-BTA-9770419", "R-BTA-9770425", "R-BTA-9770427", "R-BTA-9770428", "R-BTA-9770430" ], "enzyme_list": [ "P19120-1", "A5PJW8-1", "G3MZY8-1", "Q17R09-1", "Q29RZ2-1", "A0AAA9RV00-1", "Q08E38-1", "Q2NL22-1", "E1BH78-1", "F1MEM4-1", "F1N6W2-1", "A0A3Q1MR43-1", "A0A3Q1M155-1", "Q3T147-1", "Q5E992-1", "E1B9G4-1", "E1BDN4-1" ], "evidence": [ { "id": "R-BTA-9770141", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770141" } ] }, { "id": "R-BTA-9794542", "name": "Formation of the Spliceosomal C complex containing intron lariat", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P19120-1", "A5PJW8-1", "G3MZY8-1", "Q17R09-1", "Q29RZ2-1", "A0AAA9RV00-1", "Q08E38-1", "Q2NL22-1", "E1BH78-1", "F1N6W2-1", "A0A3Q1MR43-1", "A0A3Q1M155-1", "Q3T147-1", "Q5E992-1", "E1B9G4-1", "E1BDN4-1" ], "evidence": [ { "id": "R-BTA-9794542", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9794542" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-5688092", "participant_name": "DHX8 [nucleoplasm]", "crossref": [ { "id": "F1MEM4", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000008339", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000010976", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000010976", "database": "ENSEMBL", "url": "" }, { "id": "NP_001193020.2", "database": "RefSeq", "url": "" }, { "id": "28059", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-5688093", "participant_name": "PRPF18 [nucleoplasm]", "crossref": [ { "id": "Q2HJ41", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000017244", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000022912", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000022912", "database": "ENSEMBL", "url": "" }, { "id": "NP_001068791.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-BTA-72060", "participant_name": "DHX38 [nucleoplasm]", "crossref": [ { "id": "57044", "database": "VGNC", "url": "" }, { "id": "ENSBTAP00000042866", "database": "ENSEMBL", "url": "" }, { "id": "3.6.4.13", "database": "IntEnz", "url": "" }, { "id": "Q17R09", "database": "UniProt", "url": "" }, { "id": "ENSBTAT00000045480", "database": "ENSEMBL", "url": "" }, { "id": "NP_001069266.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAG00000013265", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-72073", "participant_name": 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{ "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A5PJW8", "gene_name": "POLR2B", "activity": [ { "ec_number": "3.1.13.-", "activity": "", "evidence": [ { "id": "A5PJW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJW8" } ] }, { "ec_number": "2.7.7.48", "activity": "RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate.", "evidence": [ { "id": "A5PJW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJW8" } ] }, { "ec_number": "2.7.7.6", "activity": "RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate.", "evidence": [ { "id": "A5PJW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJW8" } ] }, { "ec_number": "2.7.7.6", "activity": "", "evidence": [ { "id": "A5PJW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJW8" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9G4", "gene_name": "PPIL3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "E1B9G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9G4" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "E1B9G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9G4" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": 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"3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F1N6W2", "gene_name": "PPIL4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F1N6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6W2" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F1N6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6W2" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3MZY8", "gene_name": "POLR2A", "activity": [ { "ec_number": "3.1.13.-", "activity": "", "evidence": [ { "id": "G3MZY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZY8" } ] }, { "ec_number": "2.7.7.48", "activity": "RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate.", "evidence": [ { "id": "G3MZY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZY8" } ] }, { "ec_number": "2.7.7.6", "activity": "RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate.", "evidence": [ { "id": "G3MZY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZY8" } ] }, { "ec_number": "2.7.7.6", "activity": "", "evidence": [ { "id": "G3MZY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZY8" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", 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"Gene Expression" ] }, { "id": "532798", "url": "https://www.ncbi.nlm.nih.gov/gene/532798", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029774", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029774", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "WETYAKC", "url": "https://omabrowser.org/oma/group/WETYAKC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCI5", "url": "https://www.orthodb.org/?gene=E1BCI5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31022", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31022", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31022:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31022:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15748", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15748", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010818706", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010818706", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TG58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG58", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG58-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCI5", "url": "https://www.uniprot.org/uniprotkb/E1BCI5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCI5-1", "url": "https://www.uniprot.org/uniprotkb/E1BCI5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPGSGVKSEYMKRYQEPRWDEYGPCYRALRHYRLGRRLLEQAHAPWLWDDWGQAGASDDSASSASSGTGAPAPQCAPASPPPPPPAEPEGRVGPEEREVEAAGDAETRDAVDAEDAALPALPVKDVKEKPERQIRMRDPEKSASSTDPQQPPSALAARGSRKTKSPQRSSTRIKEHRHPFALYGWGEKQTDTGSQKTHNVCASAPMHEIHESALRAKSRRQVEKRRLAAQRQRAHSADVEKNRRVKPASSENPWMTEYMRCYSARA", "length": 267, "header": "tr|E1BCI5-1|E1BCI5_BOVIN Isoform 1 of Centriole, cilia and spindle associated protein OS=Bos taurus OX=9913 GN=CCSAP PE=4 SV=3 CANONICAL=E1BCI5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TG58-1", "url": "https://www.uniprot.org/uniprotkb/E1BCI5/entry#A0AAA9TG58-1", "sequence": { "sequence": "MGPVGDRAARKGGHSGPTCGTMSPGSGVKSEYMKRYQEPRWDEYGPCYRALRHYRLGRRLLEQAHAPWLWDDWGQAGASDDSASSASSGTGAPAPQCAPASPPPPPPAEPEGRVGPEEREVEAAGDAETRDAVDAEDAALPALPVKDVKEKPERQIRMRDPEKSASSTDPQQPPSALAARGSRKTKSPQRSSTRIKEHRHPFALYGWGEKQTDTGSQKTHNVCASAPMHEIHESALRAKSRRQVEKRRLAAQRQRAHSADVEKNRRVKPASSENPWMTEYMRCYSARA", "length": 288, "header": "tr|A0AAA9TG58-1|E1BCI5_BOVIN Computationally mapped isoform of Centriole, cilia and spindle associated protein OS=Bos taurus OX=9913 GN=CCSAP PE=4 SV=1 CANONICAL=E1BCI5-1" }, "locus": { "chromosome": "28", "start_pos": 1279408, "end_pos": 1263861, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122044.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122044.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097160.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097160.1" } ] } }, { "isoform_ac": "E1BCI5-1", "url": "https://www.uniprot.org/uniprotkb/E1BCI5/entry#E1BCI5-1", "sequence": { "sequence": "MSPGSGVKSEYMKRYQEPRWDEYGPCYRALRHYRLGRRLLEQAHAPWLWDDWGQAGASDDSASSASSGTGAPAPQCAPASPPPPPPAEPEGRVGPEEREVEAAGDAETRDAVDAEDAALPALPVKDVKEKPERQIRMRDPEKSASSTDPQQPPSALAARGSRKTKSPQRSSTRIKEHRHPFALYGWGEKQTDTGSQKTHNVCASAPMHEIHESALRAKSRRQVEKRRLAAQRQRAHSADVEKNRRVKPASSENPWMTEYMRCYSARA", "length": 267, "header": "tr|E1BCI5-1|E1BCI5_BOVIN Isoform 1 of Centriole, cilia and spindle associated protein OS=Bos taurus OX=9913 GN=CCSAP PE=4 SV=3 CANONICAL=E1BCI5-1" }, "locus": { "chromosome": "28", "start_pos": 1279345, "end_pos": 1263861, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000087.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000087.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000087.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000087.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1RG27-1", "protein_name": "Centriole, cilia and spindle associated protein", "gene_name": "CCSAP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSPGSGVKSEYMKRYQEPRWDEYGPCYRALRHYRLGRRLLEQAHAPWLWDDWGPASDDSASSASSGAGAPLPQCTPASPPPPAEPAARDGSDQPAHAAQEEQGAEAVGDAEDAEDAALPALSVKDIKEKPEPQIRTKETDRSPSRTEPRQPPSAFPARGGRRVVKSPQRSSSKIKENKHPFALYGWGEKQTDTGSQKTHNVCASAPVHEIHESALRAKSRRQVEKRRLVAQRQRAHSADVEKNRRVKPASSENPWMTEYMRCFSARA", "length": 267 }, "evidence": [ { "id": "E1BCI5", "url": "https://omabrowser.org/oma/group/E1BCI5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6IQ19-1", "protein_name": "Centriole, cilia and spindle-associated protein", "gene_name": "CCSAP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSPGSGVKSEYMKRYQEPRWEEYGPCYRELLHYRLGRRLLEQAHAPWLWDDWGPAGSSEDSASSESSGAGGPAPRCAPPSPPPPVEPATQEEAERRARGAPEEQDAEAGDAEAEDAEDAALPALPVKDVEDKPEQQTRTRETDKSPTSTEPRQQPSALFARGNRKAVKSPQRSSSKIKENKHPFALYGWGEKQTDTGSQKTHNVCASAPVHEIHESALRAKNRRQVEKRKLVAQRQRAHSVDVEKNRKMKASSSENPWMTEYMRCYSARA", "length": 270 }, "evidence": [ { "id": "E1BCI5", "url": "https://omabrowser.org/oma/group/E1BCI5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6P3G4-1", "protein_name": "Centriole, cilia and spindle-associated protein", "gene_name": "ccsap", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVTKRIRSEYMKKFKDPKWDTYAKCYEDLLKYRLSRRLLEQAHKPWFWGEWGSETASSGKSTPLSRNKVEPLKTLDEKPERSACVTPEPAAEAETQAAEVQDREHADTNLVPCDAEVAHPEGEEVRGKERSPAVNPDSDTQIQNMSKSKRRSSHKYTRSKVKPQAPKDPDKENRHPFALYGAGEKQTDMASKKTHNVGPAASTAEIHESALRAKTRREVEKQIKRFDKQRARSADLEKSRNKIIPDFNPWMTEYMRCFSARSR", "length": 263 }, "evidence": [ { "id": "E1BCI5", "url": "https://omabrowser.org/oma/group/E1BCI5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8QZT2-1", "protein_name": "Centriole, cilia and spindle-associated protein", "gene_name": "Ccsap", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSPGSGVKSEYMKRYREPRWDEYAPCYRELLRYRLGRRLLEQAHAPWLWDAWGPDSPSDSSASPSPAPRGALGEPSAPSAREEEQPVGERGAELRDAEEQDTVLPAPPKKDTEEKPEEHKTKETDGAPSGPGPRQQPSALCARGSKKATRSPQRSTSKIKENKHPFALYGWGERQMDMGSQKTHNVCASASVHEIHESALRAKNRRQVEKRKLAAQRQRAHSVDVEKNQRVKPASAENPWLTEYMRCYSARA", "length": 252 }, "evidence": [ { "id": "E1BCI5", "url": "https://omabrowser.org/oma/group/E1BCI5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "E1BCI5", "url": "https://www.uniprot.org/uniprotkb/E1BCI5" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "E1BCI5", "url": "https://www.uniprot.org/uniprotkb/E1BCI5" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "E1BCI5", "url": "https://www.uniprot.org/uniprotkb/E1BCI5" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "E1BCI5", "url": "https://www.uniprot.org/uniprotkb/E1BCI5" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "E1BCI5", "url": "https://www.uniprot.org/uniprotkb/E1BCI5" } ], "pmid": "" }, { "name": "mitotic spindle astral microtubule", "id": "GO:0061673", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061673", "evidence": [ { "database": "UniProtKB", "id": "E1BCI5", "url": "https://www.uniprot.org/uniprotkb/E1BCI5" } ], "pmid": "" }, { "name": "ciliary transition zone", "id": "GO:0035869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035869", "evidence": [ { "database": "UniProtKB", "id": "E1BCI5", "url": "https://www.uniprot.org/uniprotkb/E1BCI5" } ], "pmid": "" }, { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "E1BCI5", "url": "https://www.uniprot.org/uniprotkb/E1BCI5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "E1BCI5", "url": "https://www.uniprot.org/uniprotkb/E1BCI5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of mitotic spindle assembly", "id": "GO:1901673", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901673", "evidence": [ { "database": "UniProtKB", "id": "E1BCI5", "url": "https://www.uniprot.org/uniprotkb/E1BCI5" } ], "pmid": "" }, { "name": "mitotic spindle microtubule depolymerization", "id": "GO:1990755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990755", "evidence": [ { "database": "UniProtKB", "id": "E1BCI5", "url": "https://www.uniprot.org/uniprotkb/E1BCI5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], 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"table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { 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"E1BDL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDL3/entry#names_and_taxonomy" } ] }, { "name": "tRNA pseudouridine(38-40) synthase", "type": "synonym", "evidence": [ { "id": "E1BDL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDL3/entry#names_and_taxonomy" } ] }, { "name": "tRNA pseudouridylate synthase I", "type": "synonym", "evidence": [ { "id": "E1BDL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDL3/entry#names_and_taxonomy" } ] }, { "name": "tRNA-uridine isomerase I", "type": "synonym", "evidence": [ { "id": "E1BDL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDL3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TQM8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQM8#function" }, { "database": "UniProtKB", "id": "ARBA00053709", "url": "https://www.uniprot.org/uniprotkb/ARBA00053709#function" }, { "database": "UniProtKB", "id": "E1BDL3", "url": "https://www.uniprot.org/uniprotkb/E1BDL3#function" }, { "database": "UniProtKB", "id": "A0A3Q1LWZ6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWZ6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDL3", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PUS1", "url": "https://www.uniprot.org/uniprotkb/E1BDL3", "locus": { "chromosome": "17", "start_pos": 45162664, "end_pos": 45173466, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012990", "url": "https://www.ensembl.org/id/ENSBTAG00000012990" } ] } } ], "crossref": [ { "id": "E1BDL3", "url": "https://alphafold.ebi.ac.uk/entry/E1BDL3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012990", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012990", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02568", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02568", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515808", "url": "https://www.ncbi.nlm.nih.gov/gene/515808", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001406", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001406", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020094", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020094", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041708", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041708", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515808", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515808", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CDARTYT", "url": "https://omabrowser.org/oma/group/CDARTYT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LWZ6", "url": "https://www.orthodb.org/?gene=A0A3Q1LWZ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BDL3", "url": "https://www.orthodb.org/?gene=E1BDL3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11142", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11142", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11142:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11142:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01416", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01416", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002694500", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694500", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "22376", "url": "https://www.rhea-db.org/rhea/22376", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "54572", "url": "https://www.rhea-db.org/rhea/54572", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "56644", "url": "https://www.rhea-db.org/rhea/56644", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LWZ6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQM8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQM8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQM8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDL3", "url": "https://www.uniprot.org/uniprotkb/E1BDL3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDL3-1", "url": "https://www.uniprot.org/uniprotkb/E1BDL3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLPGLRAAAWALRRACGPWTPHLGPRLLCLHPMAGNGEAPIPVGAKQEQDKKARSGWQGPTRIWEETEQQAKKLKSSEDGEQQRKLPKRKIVLLMAYSGKGYHGMQRNVGSSKFKTIEDDLVSALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILEKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYVYMLPTFAFAHKDHDSQDETYRLSAETLGRVNRLLACYKGTHNFHNFTSQKGPHEPSARRYILDMFCEEPFVREGMEFAVIKVKGQSFMTHQIRKMVGLVVAIVKGYAPESVLERCWGEAKVDVPKAPGLGLVLERVHFEKYNQRFGHDGLHEPLDWAREEAEVTAFKEQHIYPTIISTERQERSMAQWLSTLPMHDFSATAHAAAGLGTKAPSSLEGSDGVGDSD", "length": 433, "header": "tr|E1BDL3-1|E1BDL3_BOVIN Isoform 1 of Pseudouridylate synthase 1 homolog OS=Bos taurus OX=9913 GN=PUS1 PE=3 SV=1 CANONICAL=E1BDL3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWZ6-1", "url": "https://www.uniprot.org/uniprotkb/E1BDL3/entry#A0A3Q1LWZ6-1", "sequence": { "sequence": "MAGVSPTPEGEPAGLHPMAGNGEAPIPVGAKQEQDKKARSGWQGPTRIWEETEQQAKKLKSSEDGEQQRKLPKRKIVLLMAYSGKGYHGMQRNVGSSKFKTIEDDLVSALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILEKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYVYMLPTFAFAHKDHDSQDETYRLSAETLGRVNRLLACYKGTHNFHNFTSQKGPHEPSARRYILDMFCEEPFVREGMEFAVIKVKGQSFMTHQIRKMVGLVVAIVKGYAPESVLERCWGEAKVDVPKAPGLGLVLERVHFEKYNQRFGHDGLHEPLDWAREEAEVTAFKEQHIYPTIISTERQERSMAQWLSTLPMHDFSATAHAAAGLGTKAPSSLEGSDGVGDSD", "length": 417, "header": "tr|A0A3Q1LWZ6-1|E1BDL3_BOVIN Computationally mapped isoform of Pseudouridylate synthase 1 homolog OS=Bos taurus OX=9913 GN=PUS1 PE=3 SV=2 CANONICAL=E1BDL3-1" }, "locus": { "chromosome": "17", "start_pos": 45172949, "end_pos": 45162933, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071667.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071667.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061734.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061734.2" } ] } }, { "isoform_ac": "A0AAA9TQM8-1", "url": "https://www.uniprot.org/uniprotkb/E1BDL3/entry#A0AAA9TQM8-1", "sequence": { "sequence": "MVHSQCREPAGSLRRLRRRPGTRLPAPGPAPKPRPIPPNTAQSRPRHQGPPQATSARLAQKDFCPRPAAVRQCSLLPPSPTCLHPMAGNGEAPIPVGAKQEQDKKARSGWQGPTRIWEETEQQAKKLKSSEDGEQQRKLPKRKIVLLMAYSGKGYHGMQRNVGSSKFKTIEDDLVSALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILEKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYVYMLPTFAFAHKDHDSQDETYRLSAETLGRVNRLLACYKGTHNFHNFTSQKGPHEPSARRYILDMFCEEPFVREGMEFAVIKVKGQSFMTHQIRKMVGLVVAIVKGYAPESVLERCWGEAKVDVPKAPGLGLVLERVHFEKYNQRFGHDGLHEPLDWAREEAEVTAFKEQHIYPTIISTERQERSMAQWLSTLPMHDFSATAHAAAGLGTKAPSSLEGSDGVGDSD", "length": 485, "header": "tr|A0AAA9TQM8-1|E1BDL3_BOVIN Computationally mapped isoform of Pseudouridylate synthase 1 homolog OS=Bos taurus OX=9913 GN=PUS1 PE=3 SV=1 CANONICAL=E1BDL3-1" }, "locus": { "chromosome": "17", "start_pos": 45173267, "end_pos": 45162933, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087579.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087579.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100676.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100676.1" } ] } }, { "isoform_ac": "E1BDL3-1", "url": "https://www.uniprot.org/uniprotkb/E1BDL3/entry#E1BDL3-1", "sequence": { "sequence": "MGLPGLRAAAWALRRACGPWTPHLGPRLLCLHPMAGNGEAPIPVGAKQEQDKKARSGWQGPTRIWEETEQQAKKLKSSEDGEQQRKLPKRKIVLLMAYSGKGYHGMQRNVGSSKFKTIEDDLVSALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILEKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYVYMLPTFAFAHKDHDSQDETYRLSAETLGRVNRLLACYKGTHNFHNFTSQKGPHEPSARRYILDMFCEEPFVREGMEFAVIKVKGQSFMTHQIRKMVGLVVAIVKGYAPESVLERCWGEAKVDVPKAPGLGLVLERVHFEKYNQRFGHDGLHEPLDWAREEAEVTAFKEQHIYPTIISTERQERSMAQWLSTLPMHDFSATAHAAAGLGTKAPSSLEGSDGVGDSD", "length": 433, "header": "tr|E1BDL3-1|E1BDL3_BOVIN Isoform 1 of Pseudouridylate synthase 1 homolog OS=Bos taurus OX=9913 GN=PUS1 PE=3 SV=1 CANONICAL=E1BDL3-1" }, "locus": { "chromosome": "17", "start_pos": 45172599, "end_pos": 45162933, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017270.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017270.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017270.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017270.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:515808", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515808", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZXM5-1", "protein_name": "Pseudouridylate synthase 1 homolog", "gene_name": "PUS1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLALRWGLRAASGGFRPRNVPLAMAKRPSGAGEGPEENGQQAKRLKGTAGEGDAEGQNKRTPKRKIVLLMAYSGKGYHGMQRNLGSSQFKTIEDDLVSALVRSGCIPENHGEDMKKMSFQRCARTDKGVSAAGQIVSLKVRLIDDILEKINNHLPSHIRILGLKRVTGGFNSKNKCDARTYAYMLPTFAFAHKDHDVQEEAYRLSREILEKVNSLLARYKGTHNFHNFTSQKGPKDPSARRYIMEMYCGEPFVREGIEFAVIKVKGQSFMMHQIRKMIGLVIAIVKGYAPESIIERSWGEEKVDVPKAPGLGLVLERVHFEKYNRRFGNDGLHEPLEWEEEEEKIAVFKEQYIYPTIINTEREEKSMMSWLNTLSIHDFNSSTAEMEANNKNSKNSDVEGSDGCNDDSD", "length": 409 }, "evidence": [ { "id": "E1BDL3", "url": "https://omabrowser.org/oma/group/E1BDL3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E1JIR1-1", "protein_name": "Pseudouridylate synthase 1 homolog", "gene_name": "Pus1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFLRRLLNDYTKAVRLKTLCNPWNRHKSFAAAMSEALDKLEVEKEARKEAKELEGEAVKDANRIKRTLKRKKWVDWKEQDEKDAANGVKRAPFDPADRIKRKKSAILLSYCGANYYGMQRNPGMQTIEEELFKAMLKHKWITEDSFEQIQISCFQRAARTDKGVSAARQVCSVKLPEELDLEAFNADLPQQIRLFGVERVTKGFNAKDQCNARTYTYTLPTVAFAPFEEKVDDVHDTFRISPELLQKVKETLKLYEGTKNFHNFTSKKSFLDPSSKRFIMSFTSSEPFRSPQDIEFVTLKVKGQSFMLHQIRKMVGLAIAIVRGNTTAATLERALTEERLDLPMAPGLGLVLDTVHYERYNDRYGKDGIHNPLTWQAQEAQVQEFIEREIFSQIYKTEAEQRNMLDWIGTLHYHSYDTRTEDAPPPSSEDKKVKGGDDDNDE", "length": 442 }, "evidence": [ { "id": "E1BDL3", "url": "https://omabrowser.org/oma/group/E1BDL3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "F1QWW1-1", "protein_name": "Pseudouridylate synthase 1 homolog", "gene_name": "pus1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLKSSCRIINSVLSQHLLQFSKLKGDQTRVFCSSFNMTEDSVKAVKRAADDDPHTETEHEDKKLKTDQEERKYPKKKVALLMAYSGKGYYGMQRNARNSQFKTIEDELVTALVGARCIPEGHAEEMKKMSFQRSARTDKGVSAVGQVVSLKVWMIENILEKINAHLPPQIRVLGCKRVTGGFNSKNNCYARTYSYMLPTVAFSPKDYNQEDTSFRLTSDTLQTVNRLFGLYKGTHNFHNFTSQKGHRDPSAMRYITHMSCGEPFIRKDVEFAVITVRGQSFMMHQIRKMIGLVIAVVKGYVDEGVIEKSWGEEKVGVPKAPGLGLVLERVHFDGYNKRFGGDGIHETLEWTEQEEAIADFKEKHIYPTIVDTELNEKSMVNWMTSLCIHDFEETATGNQDRKDDDEDGNASD", "length": 412 }, "evidence": [ { "id": "E1BDL3", "url": "https://omabrowser.org/oma/group/E1BDL3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3HCC4-1", "protein_name": "Pseudouridylate synthase 1 homolog", "gene_name": "Pus1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGFPRLWAALLRAWGRWTACPGPRVPGLPPMAANKVPPALASHQQDRKVRGGWVWEETPHPPKRVKSLEDEEAPRKLPKRKIVLLMAYSGKGYHGMQRNLGSSQFRTIEDDLVSALVQAGCIPENHGTDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILDKINSHLPSNIRILGLKRVTGGFNSKNKCDARTYCYMLPTFAFAHKDRDVQDESYRLSPETLEQVNRLLACYKGTHNFHNFTSQKGPREPSARRYILEMYCEEPFVREGLEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSWGEEKVDVPKAPGLGLVLERVHFEKYNQRFGSDGLHEPLDWAQEEGKVAAFKEQYIYPTIVSTERDERSMAQWLSTLPIHNFSATALGAAGTGAKVPSSLEGSEGDGDTD", "length": 423 }, "evidence": [ { "id": "E1BDL3", "url": "https://omabrowser.org/oma/group/E1BDL3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P53167-1", "protein_name": "tRNA pseudouridine(27/28) synthase", "gene_name": "PUS2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MLLGYCGSGYYGMQYNPPHKTIEGEILTKLFDVGAISEENSLAPKKNSFMAAARTDKGVHAMLNLLSLKITLREDTVAKLNAALPPEIRVWGIQPVNKKFNARSACDSRWYQYLIPEFILIGPPRSSLLHRNVGGCYREDGSQEVWDTFLEQTRGRFSGDELCRLQDTAQKLSESDPLVQDYVGLLSGTLSGYCLSPSKLDAFEAAMQEYVGTHNFHNFTTGKLWGDPSAQRHIKKVVVSQASPGWICVRIHGQSFMLHQIRRMVALAVLAARCQLPPNIVRNYFNAGPRKYIPRAPAQGLLLEGPVFDGYNTKLRNLLYCEIRPDDITLERMCRFRERQICTAIAHEETQRHVFCHFVRQMNRLATPLI", "length": 370 }, "evidence": [ { "id": "E1BDL3", "url": "https://omabrowser.org/oma/group/E1BDL3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q4KM92-1", "protein_name": "Pseudouridylate synthase 1 homolog", "gene_name": "Pus1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGFPRLWAALLRAWGRWTARPGPRVPGLPPMAGNKVPPALPSHQPDRKGRGGWVWEETEHPAKRVKGGEDEEPPRKLPKRKIVLLMAYSGKGYHGMQRNLGSSQFRTIEDDLVSALVQAGCIPENHGTDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILDKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYMLPTFAFAHKDRDVQDESYRLSAETLQQVNRLLGCYKGTHNFHNFTSQKGPREPSARRYILEMYCEEPFVREGLEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSWGEEKVDVPKAPGLGLVLERVHFEKYNQRFGSDGLHEPLDWAQEEGKVTAFKEQYIYPTIVSTERDERSMAQWLNTLPIHNFSGTALGADDTGAKVPSSLEGSEGDGDTD", "length": 423 }, "evidence": [ { "id": "E1BDL3", "url": "https://omabrowser.org/oma/group/E1BDL3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9SGS1-1", "protein_name": "Pseudouridine synthase family protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MLTTTTDEEIDLSCDGGVTEPQKVAIIFAFCGVGYQGMQKNPGAKTIEGELEEALFHAGAVPESIRGKPKLYDFARSARTDKGVSAVGQVVSGRFIVDPLGFVNRLNSNLPNQIRIFGYKHVTPSFSSKKFCDRRRYVYLLPVFALDPISHRDRETVMASLGPGEEYVKCFECSERGRKIPPGLVGKWKGTNFGTKSLDFQSDISSNNSSALRSDIKIEALSSNLAGLCSVDVEVGRIQEDSCKLNTNSSETKVKSKFCYGEKEKERFSRILSCYVGSYNFHNFTTRTKADDPTANRQIISFTANTVINLDGIDFIKCEVLGKSFMLHQIRKMMGLAVAIMRNCASESLIQSAFSKDVNITVPMAPEVGLYLDECFFTSYNRNFEDSHEEVSMEAYKEEAEAFKLKHIYSHIGATERKYGNMALWLHSLNYRNYPDLNFGSCGQNTDQVLVHKKIDERASHSL", "length": 463 }, "evidence": [ { "id": "E1BDL3", "url": "https://omabrowser.org/oma/group/E1BDL3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9WU56-1", "protein_name": "Pseudouridylate synthase 1 homolog", "gene_name": "Pus1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGFPRLWAALLRNWGRWTARPGPRVPGLPPMAGNKVPPALASHQPDRKGRGGWVWEETEHPAKRVKGGEDEEPPRKLPKRKIVLLMAYSGKGYHGMQRNLGSSQFRTIEDDLVSALVQAGCIPENHGTDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILDKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYMLPTFAFAHKDRDVQDESYRLSAETLQQVNRLLACYKGTHNFHNFTSQKGPREPSARRYILEMYCEEPFVREGLEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSWGEEKVDVPKAPGLGLVLERVHFEKYNQRFGGDGLHEPLDWTQEEGKVTAFKEQYIYPTIVSTERDERSMAQWLNTLPIHNFSGTALGAADTGAKVPSSLEGSEGDGDTD", "length": 423 }, "evidence": [ { "id": "E1BDL3", "url": "https://omabrowser.org/oma/group/E1BDL3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y606-1", "protein_name": "Pseudouridylate synthase 1 homolog", "gene_name": "PUS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGLQLRALLGAFGRWTLRLGPRPSCSPRMAGNAEPPPAGAACPQDRRSCSGRAGGDRVWEDGEHPAKKLKSGGDEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTIEDDLVSALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILEKINSHLPSHIRILGLKRVTGGFNSKNRCDARTYCYLLPTFAFAHKDRDVQDETYRLSAETLQQVNRLLACYKGTHNFHNFTSQKGPQDPSACRYILEMYCEEPFVREGLEFAVIRVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSWGTEKVDVPKAPGLGLVLERVHFEKYNQRFGNDGLHEPLDWAQEEGKVAAFKEEHIYPTIIGTERDERSMAQWLSTLPIHNFSATALTAGGTGAKVPSPLEGSEGDGDTD", "length": 427 }, "evidence": [ { "id": "E1BDL3", "url": "https://omabrowser.org/oma/group/E1BDL3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "tRNA pseudouridine synthesis", "id": "GO:0031119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031119", "evidence": [ { "database": "UniProtKB", "id": "E1BDL3", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "E1BDL3", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ], "pmid": "" }, { "name": "mRNA pseudouridine synthesis", "id": "GO:1990481", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990481", "evidence": [ { "database": "UniProtKB", "id": "E1BDL3", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "steroid receptor RNA activator RNA binding", "id": "GO:0002153", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002153", "evidence": [ { "database": "UniProtKB", "id": "E1BDL3", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "E1BDL3", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "E1BDL3", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ], "pmid": "" }, { "name": "tRNA binding", "id": "GO:0000049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", "evidence": [ { "database": "UniProtKB", "id": "E1BDL3", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ], "pmid": "" }, { "name": "tRNA pseudouridine(38-40) synthase activity", "id": "GO:0160147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160147", "evidence": [ { "database": "UniProtKB", "id": "E1BDL3", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ], "pmid": "" }, { "name": "mitochondrial tRNA pseudouridine(27/28) synthase activity", "id": "GO:0160153", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160153", "evidence": [ { "database": "UniProtKB", "id": "E1BDL3", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BDL3", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ], "pmid": "" }, { "name": "pseudouridine synthase activity", "id": "GO:0009982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009982", "evidence": [ { "database": "UniProtKB", "id": "E1BDL3", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BDL3", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "E1BDL3", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1BDL3", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "E1BDL3", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BDL3", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "22376", "name": "", "equation": "uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9TCW3-1", "E1BDL3-1" ], "evidence": [ { "id": "22376", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22376" } ] }, { "id": "54572", "name": "", "equation": "a uridine in tRNA = a pseudouridine in tRNA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08DI8-1", "Q5E9Z1-1", "E1BDL3-1", "A0AAA9TCW3-1", "A0AAA9T9C6-1", "Q17QT4-1" ], "evidence": [ { "id": "54572", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/54572" } ] }, { "id": "56644", "name": "", "equation": "a uridine in mRNA = a pseudouridine in mRNA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08DI8-1", "Q5E9Z1-1", "Q2TBK7-1", "E1BDL3-1", "A0AAA9T9C6-1" ], "evidence": [ { "id": "56644", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/56644" } ] } ], 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBK7" } ] } ] }, { "uniprot_ac": "Q5E9Z1", "gene_name": "RPUSD4", "activity": [ { "ec_number": "5.4.99.-", "activity": "", "evidence": [ { "id": "Q5E9Z1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Z1" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDL3" }, { "id": "PF01416", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01416" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Pseudouridine synthase I TruA alpha/beta", "eco_id": "ECO_0000259", "start_pos": 245, "end_pos": 347, "start_aa": "Tyr", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "5.4.99.12", "ec_name": "uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in 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"count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BB88-1", "uniprot_ac": "E1BB88", "uniprot_id": "E1BB88_BOVIN", "mass": { "chemical_mass": 94463.0, "monoisotopic_mass": 94463.0 }, "refseq": {}, "gene_names": [ { "name": "SIDT2", "type": "recommended", "evidence": [ { "id": "E1BB88", "database": "UniProtKB", "url": 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"https://alphafold.ebi.ac.uk/entry/E1BB88", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007192", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007192", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513462", "url": "https://www.ncbi.nlm.nih.gov/gene/513462", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR025958", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025958", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BB88", "url": "https://www.orthodb.org/?gene=E1BB88", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MVZ5", "url": "https://www.orthodb.org/?gene=F1MVZ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12185", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12185", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12185:SF16", "url": 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"MFALGLPFWALLVASVESHLGVLGPKNVSQKDAEFERTYVDEVNSELVNIYTFNHTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGLFQRKYLYQKVERTLCQPPTKNESEVQFFYVDVSTLSPVNTTYQLRVSRMDDFVLRTGEPFSFNTTAAQPQYFKYEFPEGVDSVIVKVASNTAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFIEDEPVDQGHRQKTLSVLVSRAVTSEAYVGGMLFCLGIFLSFYLLTVLLACWENWRQRKKSLLVAVDRACPESASLLGHPRVLADSFPGSSPYDGYNYGSFENGSGSTGSTDGPVDSAGPGDLSYNYPDPPGTRPRLDSMSSVEEDDYDTLADVDSDKNVIRTKQYLYVADLARKDKRVLRKKYQIYFWNIATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLGLLFLLIILQREINHNRALLRNDLCALECGIPKHFGLFYAMGTALMMEGLLSACYHVCPNYTNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGNTAFWIIFSVIHITATLLLSTQLYYMGRWKLDSGICRRILHVLYTDCIRQCSGPLYVDRMVLLVMGNIINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYIIMKLRSGERIKLIPLLCIVCTSVVWGFALFFFFQGLSTWQKTPAESREHNRDCILLDFFDDHDIWHFLSSIAMFGSFLVLLTLDDDLDTVQRDKIYVF", "length": 835, "header": "tr|E1BB88-1|E1BB88_BOVIN Isoform 1 of SID1 transmembrane family member 2 OS=Bos taurus OX=9913 GN=SIDT2 PE=3 SV=3 CANONICAL=E1BB88-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SE95-1", "url": "https://www.uniprot.org/uniprotkb/E1BB88/entry#A0AAA9SE95-1", "sequence": { "sequence": "MFALGLPFWALLVASVESHLGVLGPKNVSQKDAEFERTYVDEVNSELVNIYTFNHTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGLFQRKYLYQKVERTLCQPPTKNESEVQFFYVDVSTLSPVNTTYQLRVSRMDDFVLRTGEPFSFNTTAAQPQYFKYEFPEGVDSVIVKVASNTAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFIEDEPVDQGHRQKTLSVLVSRAVTSEAYVGGMLFCLGIFLSFYLLTVLLACWENWRQRKKSLLVAVDRACPESGHPRVLADSFPGSSPYDGYNYGSFENGSGSTGSTDGPVDSAGPGDLSYNYPDPPGTRPRLDSMSSVEEDDYDTLADVDSDKNVIRTKEHRHHCRLLCTSRGTAGDHLPDGGECHREPGHLLL", "length": 460, "header": "tr|A0AAA9SE95-1|E1BB88_BOVIN Computationally mapped isoform of SID1 transmembrane family member 2 OS=Bos taurus OX=9913 GN=SIDT2 PE=3 SV=1 CANONICAL=E1BB88-1" }, "locus": { "chromosome": "15", "start_pos": 27881162, "end_pos": 27872203, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135071.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135071.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083722.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083722.1" } ] } }, { "isoform_ac": "A0AAA9T4B8-1", "url": "https://www.uniprot.org/uniprotkb/E1BB88/entry#A0AAA9T4B8-1", "sequence": { "sequence": "MFALGLPFWALLVASVESHLGVLGPKNVSQKDAEFERTYVDEVNSELVNIYTFNHTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGLFQRKYLYQKVERTLCQPPTKNESEVQFFYVDVSTLSPVNTTYQLRVSRMDDFVLRTGEPFSFNTTAAQPQCPVYDLDNNVAFIGMYQTMTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFIEDEPVDQGHRQKTLSVLVSRAVTSEAYVGGMLFCLGIFLSFYLLTVLLACWENWRQRKKSLLVAVDRACPESGHPRVLADSFPGSSPYDGYNYGSFENGSGSTGSTDGPVDSAGPGDLSYNYPDPPGTRPRLDSMSSVEEDDYDTLADVDSDKNVIRTKQYLYVADLARKDKRVLRKKYQIYFWNIATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLGLLFLLIILQREINHNRALLRNDLCALECGIPKHFGLFYAMGTALMMEGLLSACYHVCPNYTNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGNTAFWIIFSVIHITATLLLSTQLYYMGRWKLDSGICRRILHVLYTDCIRQCSGPLYVDRMVLLVMGNIINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYIIMKLRSGERIKLIPLLCIVCTSVVWGFALFFFFQGLSTWQKTPAESREHNRDCILLDFFDDHDIWHFLSSIAMFGSFLVLLTLDDDLDTVQRDKIYVF", "length": 797, "header": "tr|A0AAA9T4B8-1|E1BB88_BOVIN Computationally mapped isoform of SID1 transmembrane family member 2 OS=Bos taurus OX=9913 GN=SIDT2 PE=3 SV=1 CANONICAL=E1BB88-1" }, "locus": { "chromosome": "15", "start_pos": 27886200, "end_pos": 27872203, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093472.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093472.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092644.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092644.1" } ] } }, { "isoform_ac": "E1BB88-1", "url": "https://www.uniprot.org/uniprotkb/E1BB88/entry#E1BB88-1", "sequence": { "sequence": "MFALGLPFWALLVASVESHLGVLGPKNVSQKDAEFERTYVDEVNSELVNIYTFNHTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGLFQRKYLYQKVERTLCQPPTKNESEVQFFYVDVSTLSPVNTTYQLRVSRMDDFVLRTGEPFSFNTTAAQPQYFKYEFPEGVDSVIVKVASNTAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFIEDEPVDQGHRQKTLSVLVSRAVTSEAYVGGMLFCLGIFLSFYLLTVLLACWENWRQRKKSLLVAVDRACPESASLLGHPRVLADSFPGSSPYDGYNYGSFENGSGSTGSTDGPVDSAGPGDLSYNYPDPPGTRPRLDSMSSVEEDDYDTLADVDSDKNVIRTKQYLYVADLARKDKRVLRKKYQIYFWNIATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLGLLFLLIILQREINHNRALLRNDLCALECGIPKHFGLFYAMGTALMMEGLLSACYHVCPNYTNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGNTAFWIIFSVIHITATLLLSTQLYYMGRWKLDSGICRRILHVLYTDCIRQCSGPLYVDRMVLLVMGNIINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYIIMKLRSGERIKLIPLLCIVCTSVVWGFALFFFFQGLSTWQKTPAESREHNRDCILLDFFDDHDIWHFLSSIAMFGSFLVLLTLDDDLDTVQRDKIYVF", "length": 835, "header": "tr|E1BB88-1|E1BB88_BOVIN Isoform 1 of SID1 transmembrane family member 2 OS=Bos taurus OX=9913 GN=SIDT2 PE=3 SV=3 CANONICAL=E1BB88-1" }, "locus": { "chromosome": "15", "start_pos": 27886200, "end_pos": 27872203, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047991.6", "url": "https://www.ensembl.org/id/ENSBTAT00000047991.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045132.4", "url": "https://www.ensembl.org/id/ENSBTAP00000045132.4" } ] } }, { "isoform_ac": "F1MVZ5-1", "url": "https://www.uniprot.org/uniprotkb/E1BB88/entry#F1MVZ5-1", "sequence": { "sequence": "MFALGLPFWALLVASVESHLGVLGPKNVSQKDAEFERTYVDEVNSELVNIYTFNHTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGLFQRKYLYQKVERTLCQPPTKNESEVQFFYVDVSTLSPVNTTYQLRVSRMDDFVLRTGEPFSFNTTAAQPQYFKYEFPEGVDSVIVKVASNTAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFIEDEPVDQGHRQKTLSVLVSRAVTSEAYVGGMLFCLGIFLSFYLLTVLLACWENWRQRKKSLLVAVDRACPESGHPRVLADSFPGSSPYDGYNYGSFENGSGSTGSTDGPVDSAGPGDLSYNYPGHDQFKRRLPFGQMRQLCIAMDPPGTRPRLDSMSSVEEDDYDTLADVDSDKNVIRTKQYLYVADLARKDKRVLRKKYQIYFWNIATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLGLLFLLIILQREINHNRALLRNDLCALECGIPKHFGLFYAMGTALMMEGLLSACYHVCPNYTNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGNTAFWIIFSVIHITATLLLSTQLYYMGRWKLDSGICRRILHVLYTDCIRQCSGPLYVDRMVLLVMGNIINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYIIMKLRSGERIKLIPLLCIVCTSVVWGFALFFFFQGLSTWQKTPAESREHNRDCILLDFFDDHDIWHFLSSIAMFGSFLVLLTLDDDLDTVQRDKIYVF", "length": 852, "header": "tr|F1MVZ5-1|E1BB88_BOVIN Computationally mapped isoform of SID1 transmembrane family member 2 OS=Bos taurus OX=9913 GN=SIDT2 PE=3 SV=2 CANONICAL=E1BB88-1" }, "locus": { "chromosome": "15", "start_pos": 27886200, "end_pos": 27872203, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009467.6", "url": "https://www.ensembl.org/id/ENSBTAT00000009467.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009467.4", "url": "https://www.ensembl.org/id/ENSBTAP00000009467.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BB88", "url": "https://www.uniprot.org/uniprotkb/E1BB88" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BB88", "url": "https://www.uniprot.org/uniprotkb/E1BB88" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "E1BB88", "url": "https://www.uniprot.org/uniprotkb/E1BB88" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "E1BB88", "url": "https://www.uniprot.org/uniprotkb/E1BB88" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "double-stranded RNA binding", "id": "GO:0003725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003725", "evidence": [ { "database": "UniProtKB", "id": "E1BB88", "url": "https://www.uniprot.org/uniprotkb/E1BB88" } ], "pmid": "" }, { "name": "RNA transmembrane transporter activity", "id": "GO:0051033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051033", "evidence": [ { "database": "UniProtKB", "id": "E1BB88", "url": "https://www.uniprot.org/uniprotkb/E1BB88" } ], "pmid": "" }, { "name": "AP-2 adaptor complex binding", "id": "GO:0035612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035612", "evidence": [ { "database": "UniProtKB", "id": "E1BB88", "url": "https://www.uniprot.org/uniprotkb/E1BB88" } ], "pmid": "" }, { "name": "AP-1 adaptor complex binding", "id": "GO:0035650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035650", "evidence": [ { "database": "UniProtKB", "id": "E1BB88", "url": "https://www.uniprot.org/uniprotkb/E1BB88" } ], "pmid": "" }, { "name": "nucleic acid transmembrane transporter activity", "id": "GO:0051032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051032", "evidence": [ { "database": "UniProtKB", "id": "E1BB88", "url": "https://www.uniprot.org/uniprotkb/E1BB88" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "RNA transport", "id": "GO:0050658", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050658", "evidence": [ { "database": "UniProtKB", "id": "E1BB88", "url": "https://www.uniprot.org/uniprotkb/E1BB88" } ], "pmid": "" }, { "name": "RNA catabolic process", "id": "GO:0006401", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006401", "evidence": [ { "database": "UniProtKB", "id": "E1BB88", "url": "https://www.uniprot.org/uniprotkb/E1BB88" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" }, { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 27, "end_pos": 29, "annotation": "n_glycosylation_sequon" }, { "start_pos": 368, "end_pos": 370, "annotation": "n_glycosylation_sequon" }, { "start_pos": 479, "end_pos": 481, "annotation": "n_glycosylation_sequon" }, { "start_pos": 499, "end_pos": 501, "annotation": "n_glycosylation_sequon" }, { "start_pos": 54, "end_pos": 56, "annotation": "n_glycosylation_sequon" }, { "start_pos": 575, "end_pos": 577, "annotation": "n_glycosylation_sequon" }, { "start_pos": 606, "end_pos": 608, "annotation": "n_glycosylation_sequon" }, { "start_pos": 60, "end_pos": 62, "annotation": "n_glycosylation_sequon" }, { "start_pos": 702, "end_pos": 704, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 123, "end_pos": 125 }, { "start_pos": 141, "end_pos": 143 }, { "start_pos": 165, "end_pos": 167 }, { "start_pos": 27, "end_pos": 29 }, { "start_pos": 368, "end_pos": 370 }, { "start_pos": 479, "end_pos": 481 }, { "start_pos": 499, "end_pos": 501 }, { "start_pos": 54, "end_pos": 56 }, { "start_pos": 575, "end_pos": 577 }, { "start_pos": 606, "end_pos": 608 }, { "start_pos": 60, "end_pos": 62 }, { "start_pos": 702, "end_pos": 704 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B9Z3-1", "uniprot_ac": "E1B9Z3", "uniprot_id": "E1B9Z3_BOVIN", "mass": { "chemical_mass": 39079.0, "monoisotopic_mass": 39079.0 }, "refseq": {}, "gene_names": [ { "name": "OR5P1C", "type": "recommended", "evidence": [ { "id": "E1B9Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Z3" } ] }, { "name": "OR5P5", "type": "recommended", "evidence": [ { "id": "E1B9Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Z3" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "E1B9Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Z3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M6H0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6H0#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" }, { "database": "UniProtKB", "id": "E1B9Z3", "url": "https://www.uniprot.org/uniprotkb/E1B9Z3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9Z3", "url": "https://www.uniprot.org/uniprotkb/E1B9Z3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR5P1C", "url": "https://www.uniprot.org/uniprotkb/E1B9Z3", "locus": {} } ], "crossref": [ { "id": "E1B9Z3", "url": "https://alphafold.ebi.ac.uk/entry/E1B9Z3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000049870", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049870", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15416", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15416", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M6H0", "url": "https://www.orthodb.org/?gene=A0A3Q1M6H0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B9Z3", "url": "https://www.orthodb.org/?gene=E1B9Z3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M6H0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6H0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M6H0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6H0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9Z3", "url": "https://www.uniprot.org/uniprotkb/E1B9Z3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9Z3-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Z3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSADINLLALDFSPSSFLKNEQNGQSWSNHSVAPKQGIIPSKMEIGNHTMVTEFVILGLTDHPTLCSIFFLVFLGIYVATILGNISIITLIHRSPQLHTPMYLFLSHLAFVDIGYSSSVTPIMIVSFLEVRTTIPVAGCIVQLGSDVIFGTAECFLLAAMAYDRYVAICSPLLYSTYMSPRVCVILLIASYLGGCVNASSFIGCLLSLTFCGPNKINHFFCDLPPLVKLSCTHVYVAEISPAISAGSIIVITLFTIIVSYLYILHSILKMCSTEGRSKAFSTCTSHLTAVTLFYGTVTFVYVIPKSSYSPDHIKVVSVFYTVVIPMLNPLIYSLRNKEVKEAMRKLMTKIHQSF", "length": 355, "header": "tr|E1B9Z3-1|E1B9Z3_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5P1C PE=3 SV=3 CANONICAL=E1B9Z3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M6H0-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Z3/entry#A0A3Q1M6H0-1", "sequence": { "sequence": "MRIYVATILGNISIITLIHRSPQLHTPMYLFLSHLAFVDIGYSSSVTPIMIVSFLEVRTTIPVAGCIVQLGSDVIFGTAECFLLAAMAYDRYVAICSPLLYSTYMSPRVCVILLIASYLGGCVNASSFIGCLLSLTFCGPNKINHFFCDLPPLVKLSCTHVYVAEISPAISAGSIIVITLFTIIVSYLYILHSILKMCSTEGRSKAFSTCTSHLTAVTLFYGTVTFVYVIPKSSYSPDHIKVVSVFYTVVIPMLNPLIYSLRNKEVKEAMRKLMTKIHQSF", "length": 281, "header": "tr|A0A3Q1M6H0-1|E1B9Z3_BOVIN Computationally mapped isoform of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5P1C PE=3 SV=2 CANONICAL=E1B9Z3-1" }, "locus": { "chromosome": "15", "start_pos": 45052899, "end_pos": 44973442, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073753.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073753.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063902.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063902.2" } ] } }, { "isoform_ac": "E1B9Z3-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Z3/entry#E1B9Z3-1", "sequence": { "sequence": 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"sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B6Z5-1", "uniprot_ac": "E1B6Z5", "uniprot_id": "E1B6Z5_BOVIN", "mass": { "chemical_mass": 89700.0, "monoisotopic_mass": 89700.0 }, "refseq": {}, "gene_names": [ { "name": "CCNT2", "type": "recommended", "evidence": [ { "id": "E1B6Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5" } ] } ], "protein_names": [ { "name": "Cyclin-T1", "type": "recommended", "evidence": [ { "id": "E1B6Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MA24", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA24#function" }, { "database": "UniProtKB", "id": "ARBA00045498", "url": "https://www.uniprot.org/uniprotkb/ARBA00045498#function" }, { "database": "UniProtKB", "id": "E1B6Z5", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B6Z5", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCNT2", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5", "locus": { "chromosome": "2", "start_pos": 62319905, "end_pos": 62352391, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014158", "url": "https://www.ensembl.org/id/ENSBTAG00000014158" } ] } } ], "crossref": [ { "id": "E1B6Z5", "url": "https://alphafold.ebi.ac.uk/entry/E1B6Z5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014158", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014158", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20596", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20596", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20598", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20598", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR006671", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006671", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047321", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047321", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "SCSVKQY", "url": "https://omabrowser.org/oma/group/SCSVKQY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MA24", "url": "https://www.orthodb.org/?gene=A0A3Q1MA24", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B6Z5", "url": "https://www.orthodb.org/?gene=E1B6Z5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10026", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10026", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00134", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00134", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21797", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21797", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-112382", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112382", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2173796", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2173796", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-674695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-674695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6796648", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6796648", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6807505", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807505", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-75955", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75955", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MA24", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MA24-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA24-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B6Z5", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B6Z5-1", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSGAEHCGPVRESEDGGRKEKAKGLGEPIGRSPRTRTRGDWGEKGQCLVYGERSGAGSRGLGGESASPEGRGVGEGAGGGGSVMASGRGASSRWFFTREQLENTPSRRCGVEADKELSYRQQAANLIQEMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFSRYMISPTALFLAAKVEEQARKLEHVIKVAHACLHPLEPLLDTKCDTYLQQTQELVLLETIMLQTLGFEITIEHPHTDVVKCTQLVRASKDLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDGKHWWEYVDPTVTLELLDELTHEFLQILEKTPSRLKKIRYWRANQAAGKPKVDGQVSETPLLGSSLVQNSMLVDSVTGVPTKPSFQKPSTSAFPAPVPLNSGNISVQDSHASDNLSMLATGMPSTSYGLSSHQEWPQHQESARTEQIYSQKQEISGSQYNINFKQGPSVSLHSGLHHRPDKISDHSSVKQDYTHKAGSSKHHGPISATPGVIPQKMSLDKYREKRKLESLDLDARDHYIAAQVEQQHKHVQSQAASSSSVTSPIKMKIPITNAEKPEKYMAEKKEKSGSLKLRIPIPPTDKSVSKEELKMKIKVSSSERHSSSDEGSGKSKHSSPHISRDHKEKHKEHPSNRHHPSSHKHSHSYSGSSSGGSKHSADGIAPTVLRSPVGLSSDGISSSSSSSRKKLHINDASHNHHSKMSKSSKSSGSSSSSSSSVKQYISSHNSVFNHPLPPPPPVTYQVGYGHLSTLVKLDKKPVETNGPDVNHEYSTNSQHMDYKDTFDMLDSLLSAQGMNM", "length": 815, "header": "tr|E1B6Z5-1|E1B6Z5_BOVIN Isoform 1 of Cyclin-T1 OS=Bos taurus OX=9913 GN=CCNT2 PE=3 SV=3 CANONICAL=E1B6Z5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MA24-1", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5/entry#A0A3Q1MA24-1", "sequence": { "sequence": "MTSGAEHCGPVRESEDGGRKEKAKGLGEPIGRSPRTRTRGDWGEKGQCLVYGERSGAGSRGLGGESASPEGRGVGEGAGGGGSVMASGRGASSRWFFTREQLENTPSRRCGVEADKELSYRQQAANLIQEMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFSRYMISPTALFLAAKVEEQARKLEHVIKVAHACLHPLEPLLDTKCDTYLQQTQELVLLETIMLQTLGFEITIEHPHTDVVKCTQLVRASKDLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDGKHWWEYVDPTVTLELLDELTHEFLQILEKTPSRLKKIRYWRANQAAGKPKVDGQVSETPLLGSSLVQNSMLVDSVTGVPTKPSFQKPSTSAFPAPVPLNSGNISVQDSHASDNLSMLATGMPSTSYGLSSHQEWPQHQESARTEQIYSQKQEISGSQYNINFKQGPSVSLHSGLHHRPDKISDHSSVKQDYTHKAGSSKHHGPISATPGVIPQKMSLDKYREKRKLESLDLDARDHYIAAQVEQQHKHVQSQAASSSSVTSPIKMKIPITNAEKPEKYMAEKKEKSGSLKLRIPIPPTDKSVSKEELKMKIKVSSSERHSSSDEGSGKSKHSSPHISRDHKEKHKEHPSNRHHPSSHKHSHSYSGSSSGGSKHSADGIAPTVLRSPVGLSSDGISSSSSSSRKKLHINDASHNHHSKMSKSSKSSGGLRTSQHPRETGQEASGDQRS", "length": 748, "header": "tr|A0A3Q1MA24-1|E1B6Z5_BOVIN Computationally mapped isoform of Cyclin-T1 OS=Bos taurus OX=9913 GN=CCNT2 PE=3 SV=1 CANONICAL=E1B6Z5-1" }, "locus": { "chromosome": "2", "start_pos": 62352192, "end_pos": 62322799, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074231.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074231.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067058.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067058.1" } ] } }, { "isoform_ac": "E1B6Z5-1", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5/entry#E1B6Z5-1", "sequence": { "sequence": "MTSGAEHCGPVRESEDGGRKEKAKGLGEPIGRSPRTRTRGDWGEKGQCLVYGERSGAGSRGLGGESASPEGRGVGEGAGGGGSVMASGRGASSRWFFTREQLENTPSRRCGVEADKELSYRQQAANLIQEMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFSRYMISPTALFLAAKVEEQARKLEHVIKVAHACLHPLEPLLDTKCDTYLQQTQELVLLETIMLQTLGFEITIEHPHTDVVKCTQLVRASKDLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDGKHWWEYVDPTVTLELLDELTHEFLQILEKTPSRLKKIRYWRANQAAGKPKVDGQVSETPLLGSSLVQNSMLVDSVTGVPTKPSFQKPSTSAFPAPVPLNSGNISVQDSHASDNLSMLATGMPSTSYGLSSHQEWPQHQESARTEQIYSQKQEISGSQYNINFKQGPSVSLHSGLHHRPDKISDHSSVKQDYTHKAGSSKHHGPISATPGVIPQKMSLDKYREKRKLESLDLDARDHYIAAQVEQQHKHVQSQAASSSSVTSPIKMKIPITNAEKPEKYMAEKKEKSGSLKLRIPIPPTDKSVSKEELKMKIKVSSSERHSSSDEGSGKSKHSSPHISRDHKEKHKEHPSNRHHPSSHKHSHSYSGSSSGGSKHSADGIAPTVLRSPVGLSSDGISSSSSSSRKKLHINDASHNHHSKMSKSSKSSGSSSSSSSSVKQYISSHNSVFNHPLPPPPPVTYQVGYGHLSTLVKLDKKPVETNGPDVNHEYSTNSQHMDYKDTFDMLDSLLSAQGMNM", "length": 815, "header": "tr|E1B6Z5-1|E1B6Z5_BOVIN Isoform 1 of Cyclin-T1 OS=Bos taurus OX=9913 GN=CCNT2 PE=3 SV=3 CANONICAL=E1B6Z5-1" }, "locus": { "chromosome": "2", "start_pos": 62352192, "end_pos": 62322699, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018816.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018816.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018816.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018816.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 508, "start_aa": "Thr", "end_pos": 508, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr508", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-112382", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112382", "resource": "Reactome", "description": "Formation of RNA Pol II elongation complex" }, { "id": "R-BTA-2173796", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2173796", "resource": "Reactome", "description": "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription" }, { "id": "R-BTA-674695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-674695", "resource": "Reactome", "description": "RNA Polymerase II Pre-transcription Events" }, { "id": "R-BTA-6796648", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6796648", "resource": "Reactome", "description": "TP53 Regulates Transcription of DNA Repair Genes" }, { "id": "R-BTA-6807505", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807505", "resource": "Reactome", "description": "RNA polymerase II transcribes snRNA genes" }, { "id": "R-BTA-75955", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75955", "resource": "Reactome", "description": "RNA Polymerase II Transcription Elongation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A2R8QAB1-1", "protein_name": "Cyclin-T2a isoform 1", "gene_name": "ccnt2a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAACRGSSSKWFFTREQLETTPSRRCGVEPDRELSYRQQAANLIQDMGQRLNVSQLTINTAIVYMHRFYMYHSFTKFHRNIISPTTLFLAAKVEEQPRKLEHVIKVAHACLNPQEPPLDTKSNAYLQQAQELVILETIVLQTLGFEITIEHPHTDVVKCSQLVRASKDLAQTSYFMATNSLHLTTFCLQHKPTVIACVCIHLACKWSNWEIPVSTDGKHWWEYVDNSVTLELLDELTHEFLQILEKTPSRLKRIRNWRATQAAKKPKSDNQGSDSSSLAGSSLTQDPSLMDTLPGVSTSTAFSKGSTSFPVCLSGNSSSSLSLDSIANMQGTSYTYTAPSDWPQDQLRSDPYSVKQLPSHSSMHPQRPDKSADLNPTKHEHKVSGGTKHQATTYPPHAAPTQKMSLDKYREKHAAELAVQKRKQEQQNVETEVYGATTQTDHRKHLPHLSHGQQGAGVTTASPLKIKLPGQDKIQDKCEKGSSLKLRLPVPSQSEKGGSSKEELKMKIKVSSERHSSSDEGAAKSKHSSPLVSKEKHRDHSAHRHHHKHGHSHTHTHSGNGRSSLEVPTTGSVADGPSSASSSSRKRVNPEASHNHHSKKNKSSKSGAGSSSHCSSVQQCVSSHNSVLNLPFPPPPVTYQVGYGHLSTLVKLDRKPVESHGPENACLANGQHTDCKDTFVMLDSLLSAQAMNS", "length": 693 }, "evidence": [ { "id": "E1B6Z5", "url": "https://omabrowser.org/oma/group/E1B6Z5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0ZBG8-1", "protein_name": "Cyclin T2", "gene_name": "CCNT2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEGGGEEAGAALPPAGGAAGGGGGSVMAAAGSGAGTSTRGGGGSSAASRWFFSREQLENTPSRRCGVEADKELSYRQQAANLIQDMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFNRNIISPTALFLAAKVEEQPRKLEHVIKVVNACLHPHEPQLDTKCDAYLQQAQELVILETIMLQTLGFEITIEHPHTDVVKCTQLVRASKDLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDGKHWWEYVDPSVTLELLDELTHEFLQILEKTPSRLKRIRNWRANQAAKKPKGDGQVSENSLLGSSLVQNSILVDTVTGVAANTSFQKPSTSFPAPVPLTSGSISVPDSHAPENLAILATGMPSTSYNLASHQEWPQHQEQTRTEQIYSQKQEALPPSQYNMNFQQGTSVQLHAGVHHRPDKLAEHSTVKQEYSHKSGNKHHGQVAAPIIIPQKMSLDKYREKRKLETLELDVREHYVATPGEQTHKKHVQAQSASSTSVTSPIKMKIPIANAEKPEKHLTDKKEKSGSLKLRIPIPPTEKGASKEELKMKIKVSSSERHSSSDEGSGKSKHSSPHVSKEHKEKHKEHSLNRHHSIGHKHSHSHSGGSSSGGSKHNTDGLTPTVLRSPVGLGLSSDGNSSSSSSSRKKLYSNDASHNHHSKMSKSSKSSGSSSSSSSVKQYVSSHNSVFNLPLPPPPPVTYQVGYGHLSTLVKLDRKPVENGPDASHQYSTNSQHMDYKDTFDMLDSLLSAQGMNI", "length": 770 }, "evidence": [ { "id": "E1B6Z5", "url": "https://omabrowser.org/oma/group/E1B6Z5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8W4F719-1", "protein_name": "Cyclin T2", "gene_name": "CCNT2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "SQLTINTAIVYMHRFYMHHSFTKFNRYTISPTALFLAAKVEEQARKLEHVIKVAHACLHPLEPLLDTKCDAYLQQTQELVLLETIMLQTLGFEITIEHPHTDVVKCTQLVRASKDLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDGKHWWEYVDPTVTLELLDELTHEFLQILEKTPSRLKKIRNWRATQTVKKPKVDGQVSETPLLGSSLVQNSILVDSVTGVPTNPSFQKPSTSAFPAPVPLNSGNISVQDSHTSDNLSMLATGMPGTSYGLSSHQEWPQHQESARTEQIYSQKQETSLSGSQYNINFQQGPSISMHSGLHHRPDKISDHSSIKQDYTHKAGSSKHHGPISATPGVIPQKMSLDKYREKRKLETLDLDVRDHYIAAQVEQQHKHGQSQAASSSSVTSPIKMKIPITNAEKPDKYMADKKEKSGSLKLRIPIPPTDKSISKEELKMKIKVSSSERHSSSDEGSGKSKHSSPHISRDHKEKHKEHPSNRHHPSSHKHSHSYSGSSSGGSKHSADGIPPTVLRSPVGLSSDGISSSSSSSRKKLHINDASHNHHSKMSKSSKSSGSSSSSSSSVKQYISSHNSVFNHPLPPPPPVTYQVGYGHLSTLVKLDKKPVETNGPDVNHEYSTNSQHMDYKDTFDMLDSLLSAQGMNM", "length": 680 }, "evidence": [ { "id": "E1B6Z5", "url": "https://omabrowser.org/oma/group/E1B6Z5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZGL6-1", "protein_name": "Cyclin T2", "gene_name": "Ccnt2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASGRGASSRWFFTREQLENTPSRRCGVEADEELSHRQQAANLIQDMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFNRNIISPTALFLAAKVEEQARKLEHVIKVAHACLHPLEPLLDTKCDAYLQQTQELVLLETIMLQTLGFEITIEHPHTDVVKCTQLVRASKDLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDGKHWWEYVDPTVTLELLDELTHEFLQILEKTPSRLKRIRNWRAMAKKPKVDGQVSETPLLGSSLVQNSILVDSVTGVPANPSFQKPSTSTFPAPLPLTSGSTSVQDGRASDTGSVLAGMPSSSYTVSSHQEWPHHPDSARTDPVYTQKQEATLSGSQYLSFQQGPSMALHSGLHHRPDKVADHSSAKQEYTHKGGSSKHHGPIPATPGVVPQKMSLDKYREKRKLETLDLDSRDHYMAAHAEQQHKHGPAQAVAGTSVTSPIKMKLPLTNSDKPEKHLAEKRERSGSLKLRIPIPPPDKGPSKEELKMKIKVSSSERHSSSDEGSGKSKHSSPHISRDHKEKHKEHPANRHHSSHKHLHMHSSGGSKHADGMPPTVLRSPVGLGPEGISSGPSARKKLHINDASHNHHSKMSKSSKSSGSSSSSSSVKQYLSSHSSVFNHPLPPPPPVTYQVGYGHLSTLVKLDKKPVEPHGPEANHEYSTSSQHMDYKDTFDMLDSLLSAQGMNM", "length": 722 }, "evidence": [ { "id": "E1B6Z5", "url": "https://omabrowser.org/oma/group/E1B6Z5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3GZQ2-1", "protein_name": "Cyclin-T2 isoform X1", "gene_name": "Ccnt2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASGRGASSRWFFTREQLENTPSRRCGVEADEELSHRQQAANLIQDMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFNRNIISPTALFLAAKVEEQARKLEHVIKVAHACLHPLEPLLDTKCDAYLQQTQELVLLETIMLQTLGFEITIEHPHTDVVKCTQLVRASKDLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDGKHWWEYVDPTVTLELLDELTHEFLQILEKTPSRLKRIRNWRAMAKKPKVDGQVSETPLLGSSLVQNSLLVDSVTGVPANPSFQKPSTSTFPAPIPLNPGNTSVQDSRASDTLSVLAAGMPSTSYSLSSHQEWPQHPDSARTDPVYTQKQEATLSGSQYISFQQGPSMTLHSGLHHRPDKIADHSSAKQEYAHKSGSSKHHGPIPAAPGVVPQKMSLDKYREKRKLETLDLDTRDHYIAAHVEQQHKHGPAQAVAGSSVTSPIKMKLPVTNSDKSEKHMAEKKEKSGSLKLRIPIPPPDKGPSKEELKMKIKVSSSERHSSSDEGSGKSKHSSPHINRDHKEKHKEHPANRYHSSHKHLHMLSGGGSKHAADGMPPTVLRSPVGLGPDSISSSSSARKKLHINDASHNHHSKMSKSSKSSGSSSSSSSVKQYLSSHSSVFNHPLPPPPPVTYQVGYGHLSTLVKLDKKPVEPHGPEANHEYSTSSQHLDYKDTFDMLDSLLSAQGMNM", "length": 724 }, "evidence": [ { "id": "E1B6Z5", "url": "https://omabrowser.org/oma/group/E1B6Z5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O60583-1", "protein_name": "Cyclin-T2", "gene_name": "CCNT2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASGRGASSRWFFTREQLENTPSRRCGVEADKELSCRQQAANLIQEMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFNKNIISSTALFLAAKVEEQARKLEHVIKVAHACLHPLEPLLDTKCDAYLQQTQELVILETIMLQTLGFEITIEHPHTDVVKCTQLVRASKDLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDGKHWWEYVDPTVTLELLDELTHEFLQILEKTPNRLKKIRNWRANQAARKPKVDGQVSETPLLGSSLVQNSILVDSVTGVPTNPSFQKPSTSAFPAPVPLNSGNISVQDSHTSDNLSMLATGMPSTSYGLSSHQEWPQHQDSARTEQLYSQKQETSLSGSQYNINFQQGPSISLHSGLHHRPDKISDHSSVKQEYTHKAGSSKHHGPISTTPGIIPQKMSLDKYREKRKLETLDLDVRDHYIAAQVEQQHKQGQSQAASSSSVTSPIKMKIPIANTEKYMADKKEKSGSLKLRIPIPPTDKSASKEELKMKIKVSSSERHSSSDEGSGKSKHSSPHISRDHKEKHKEHPSSRHHTSSHKHSHSHSGSSSGGSKHSADGIPPTVLRSPVGLSSDGISSSSSSSRKRLHVNDASHNHHSKMSKSSKSSGSSSSSSSSVKQYISSHNSVFNHPLPPPPPVTYQVGYGHLSTLVKLDKKPVETNGPDANHEYSTSSQHMDYKDTFDMLDSLLSAQGMNM", "length": 730 }, "evidence": [ { "id": "E1B6Z5", "url": "https://omabrowser.org/oma/group/E1B6Z5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7TQK0-1", "protein_name": "Cyclin-T2", "gene_name": "Ccnt2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASGRGASSRWFFTREQLENTPSRRCGVEADEELSHRQQAANLIQDMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFNRNIISPTALFLAAKVEEQARKLEHVIKVAHACLHPLEPLLDTKCDAYLQQTQELVLLETIMLQTLGFEITIEHPHTDVVKCTQLVRASKDLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDGKHWWEYVDPTVTLELLDELTHEFLQILEKTPSRLKRIRNWRAMAKKPKVDGQVSETPLLGSSLVQNSILVDSVTGVPANPSFQKPSTSTFPAPIPLNSGSTSVQDSRASDNLSVLAAGMPSTSYSLSSHQEWPQHPDSARTDPVYTQKQEATLSGSQYISFQQGPSMALHSGLHHRPDKVADHSSAKQEYTHKAGSSKHHGPIPATPGMLPQKMSLDKYREKRKLETLDVDTRDHYLAAHAEQQHKHGPAQAVTGTSVTSPIKMKLPLTNSDRPEKHVAEKKERSGSLKLRIPIPPPDKGPSKEELKMKIKVASSERHSSSDEGSGKSKHSSPHISRDHKEKHKEHPANRHHSSHKYLHMHSGGSKHTADGMPPTVLRSPVGLGPEGVSSASSARKKLHSSEASHNHHSKMSKSSKSAGSSSSSSSVKQYLSSHSSVFNHPLPPPPPVTYQVGYGHLSTLVKLDKKPVEPHGPEANHEYSTSSQHMDYKDTFDMLDSLLSAQGMNM", "length": 723 }, "evidence": [ { "id": "E1B6Z5", "url": "https://omabrowser.org/oma/group/E1B6Z5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B6Z5", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5" } ], "pmid": "" }, { "name": "cyclin/CDK positive transcription elongation factor complex", "id": "GO:0008024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008024", "evidence": [ { "database": "UniProtKB", "id": "E1B6Z5", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "E1B6Z5", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1B6Z5", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "E1B6Z5", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "E1B6Z5", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription, elongation", "id": "GO:0032786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032786", "evidence": [ { "database": "UniProtKB", "id": "E1B6Z5", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5" } ], "pmid": "" }, { "name": "early viral transcription", "id": "GO:0019085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019085", "evidence": [ { "database": "UniProtKB", "id": "E1B6Z5", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5" } ], "pmid": "" }, { "name": "late viral transcription", "id": "GO:0019086", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019086", "evidence": [ { "database": "UniProtKB", "id": "E1B6Z5", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5" } ], "pmid": "" }, { "name": "skeletal muscle tissue development", "id": "GO:0007519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007519", "evidence": [ { "database": "UniProtKB", "id": "E1B6Z5", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "cyclin-dependent protein serine/threonine kinase activator activity", "id": "GO:0061575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061575", "evidence": [ { "database": "UniProtKB", "id": "E1B6Z5", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "E1B6Z5", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5" } ], "pmid": "" }, { "name": "RNA polymerase binding", "id": "GO:0070063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070063", "evidence": [ { "database": "UniProtKB", "id": "E1B6Z5", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5" } ], "pmid": "" }, { "name": "transcription coactivator binding", "id": "GO:0001223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001223", "evidence": [ { "database": "UniProtKB", "id": "E1B6Z5", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5" } ], "pmid": "" }, { "name": "7SK snRNA binding", "id": "GO:0097322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097322", "evidence": [ { "database": "UniProtKB", "id": "E1B6Z5", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5" } ], "pmid": "" }, { "name": "cyclin-dependent protein serine/threonine kinase regulator activity", "id": "GO:0016538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016538", "evidence": [ { "database": "UniProtKB", "id": "E1B6Z5", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 136, "end_pos": 138, "annotation": "n_glycosylation_sequon" }, { "start_pos": 403, "end_pos": 405, "annotation": "n_glycosylation_sequon" }, { "start_pos": 414, "end_pos": 416, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B6Z5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 815, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B6Z5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B6Z5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B6Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6Z5" }, { "id": "SM00385", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00385" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cyclin-like", "eco_id": "ECO_0000259", "start_pos": 126, "end_pos": 225, "start_aa": "Asn", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 508 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 136, "end_pos": 138 }, { "start_pos": 403, "end_pos": 405 }, { "start_pos": 414, "end_pos": 416 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDL7-1", "uniprot_ac": "E1BDL7", "uniprot_id": "E1BDL7_BOVIN", "mass": { "chemical_mass": 176726.0, "monoisotopic_mass": 176726.0 }, "refseq": {}, "gene_names": [ { "name": "PREX2", "type": "recommended", "evidence": [ { "id": "E1BDL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDL7" } ] } ], "protein_names": [ { "name": "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein", "type": "recommended", "evidence": [ { "id": "E1BDL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDL7/entry#names_and_taxonomy" } ] }, { "name": "DEP domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "E1BDL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDL7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.", "evidence": [ { "database": "UniProtKB", "id": "E1BDL7", "url": "https://www.uniprot.org/uniprotkb/E1BDL7#function" }, { "database": "UniProtKB", "id": "ARBA00058808", "url": "https://www.uniprot.org/uniprotkb/ARBA00058808#function" }, { "database": "UniProtKB", "id": "A0A3Q1MBZ6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBZ6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDL7", "url": "https://www.uniprot.org/uniprotkb/E1BDL7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PREX2", "url": "https://www.uniprot.org/uniprotkb/E1BDL7", "locus": { "chromosome": "14", "start_pos": 32272520, "end_pos": 31977409, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022169", "url": "https://www.ensembl.org/id/ENSBTAG00000022169" } ] } } ], "crossref": [ { "id": "ENSBTAG00000022169", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022169", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00160", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00160", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01224", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01224", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04439", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04439", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06710", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06710", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037367", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037367", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055251", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055251", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MBZ6", "url": "https://www.orthodb.org/?gene=A0A3Q1MBZ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BDL7", "url": "https://www.orthodb.org/?gene=E1BDL7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22829", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22829", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22829:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22829:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00610", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00610", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00621", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00621", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22697", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22697", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948751", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MBZ6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDL7", "url": "https://www.uniprot.org/uniprotkb/E1BDL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDL7-1", "url": "https://www.uniprot.org/uniprotkb/E1BDL7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNQCAASKLDKNVTEETVKMLFSNIEDILAVHKEFLKAVEECLHPEPNAQQEVGTCFLQFKDKFRIYDEYCSNHEKAQKLLFELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLLLKELLKRTPRKHSDYAALMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCKQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVISKGVRLYCRLHSLFTPVVRDKDYHLRTYKSVVMANKLIDWLIAQGDCRSREEAMIFGIGLCDNGFMHHVLEKSEFKDEPLLFRFFADEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCLNSRKPLRVLVSTKPRETVKIPDSAEGLGFQIRGYGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSVESAQEDLQKSNSKPPGDEAGDSFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNVVEKMIEPKGFFSLTAKILEALAKSDDHFVQNCTSLSSLNEVIPTDLQSKFSAICSEKIERICQRISSYKKFSRVLKNRAWPTFKQAKSRISPLHSSDFCPTNCHVNVMEVSYPKTSTSLGSAFGVQLDSRKHNSHDKENKSEQGKLSPMVYIQHTITTMAAPSGLSLGQQDGHGLRYLLKEEDLETQDIYQKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKASESIVPTDSDNEKGERNSKRVCFNMAGDEQEDSGHDTISNRDSYSDCNSNRNSVASFTSICSSQCSSYFHSDEMDSGDELPLNVRISRDKQDKIHSCLEHLFSQVDSITNLLRGQAVVRAFEQTKYLTPGRGLQEFQQEMEPKLSCPKRLRLHIKQDPWNLPSSVRNLAQNIRRFVEEVKCRILLALLEYSDSETQLRRDMVFCQSLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSPNLTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQALKIYFYIDSYHFEQLPQRLKNGGGFKIHPVLFSQALESMEGYYYRDNVSVEEFQAQINAASLEKVKQYNQKLRAFYLDKSNSPPNSTSKAAYIDKLMRPLNVLDELYRLVASFIRSKRTAACVNTACSASGVGLLSVSSELCSRLGACHVIMCNSGVHRCTLSVTLEQAIILARSHGLPPRYIMQATDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPVGEE", "length": 1553, "header": "tr|E1BDL7-1|E1BDL7_BOVIN Isoform 1 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein OS=Bos taurus OX=9913 GN=PREX2 PE=4 SV=3 CANONICAL=E1BDL7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MBZ6-1", "url": "https://www.uniprot.org/uniprotkb/E1BDL7/entry#A0A3Q1MBZ6-1", "sequence": { "sequence": "MNQCAASKLDKNVTEETVKMLFSNIEDILAVHKEFLKAVEECLHPEPNAQQEVGTCFLQFKDKFRIYDEYCSNHEKAQKLLFELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLLLKELLKRTPRKHSDYAALMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCKQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVISKGVRLYCRLHSLFTPVVRDKDYHLRTYKSVVMANKLIDWLIAQGDCRSREEAMIFGIGLCDNGFMHHVLEKSEFKDEPLLFRFFADEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCLNSRKPLRVLVSTKPRETVKIPDSAEGLGFQIRGYGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSVESAQEDLQKSNSKPPGDEAGDSFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNVVEKMIEPKGFFSLTAKILEALAKSDDHFVQNCTSLSSLNEVIPTDLQSKFSAICSEKIERICQRISSYKKFSRVLKNRAWPTFKQAKSRISPLHSSDFCPTNCHVNVMEVSYPKTSTSLGSAFGVQLDSRKHNSHDKENKSEQGKLSPMVYIQHTITTMAAPSGLSLGQQDGHGLRYLLKEEDLETQDIYQKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKASESIVPTDSDNEKGERNSKRVCFNMAGDEQEDSGHDTISNRDSYSDCNSNRNSVASFTSICSSQCSSYFHSDEMDSGDELPLNVRISRDKQDKIHSCLEHLFSQVDSITNLLRGQAVVRAFEQTKYLTPGRGLQEFQQEMEPKLSCPKRLRLHIKQDPWNLPSSVRNLAQNIRRFVEEVKCRILLALLEYSDSETQLRRDMVFCQSLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSPNLTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQALKIYFYIDSYHFEQLPQRLKNGGGFKIHPVLFSQALESMEGYYYRDNVSVEEFQAQINAASLEKVKQYNQKLRAFYLDKSNSPPNSTSKAAYIDKLMRPLNVLDELYRLVASFIRSKRTAACVNTACSASGVGLLSVSSELCSRLGACHVIMCNSGVHREQEFRTQQRIWESETGLRSLLQGCTSCVSRLLRLEKNEEHLQGTRQAEASEHWMRQRTCWLNILHST", "length": 1549, "header": "tr|A0A3Q1MBZ6-1|E1BDL7_BOVIN Computationally mapped isoform of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein OS=Bos taurus OX=9913 GN=PREX2 PE=4 SV=1 CANONICAL=E1BDL7-1" }, "locus": { "chromosome": "14", "start_pos": 32270677, "end_pos": 32049455, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074518.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074518.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071612.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071612.1" } ] } }, { "isoform_ac": "E1BDL7-1", "url": "https://www.uniprot.org/uniprotkb/E1BDL7/entry#E1BDL7-1", "sequence": { "sequence": "MNQCAASKLDKNVTEETVKMLFSNIEDILAVHKEFLKAVEECLHPEPNAQQEVGTCFLQFKDKFRIYDEYCSNHEKAQKLLFELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLLLKELLKRTPRKHSDYAALMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCKQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVISKGVRLYCRLHSLFTPVVRDKDYHLRTYKSVVMANKLIDWLIAQGDCRSREEAMIFGIGLCDNGFMHHVLEKSEFKDEPLLFRFFADEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCLNSRKPLRVLVSTKPRETVKIPDSAEGLGFQIRGYGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSVESAQEDLQKSNSKPPGDEAGDSFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNVVEKMIEPKGFFSLTAKILEALAKSDDHFVQNCTSLSSLNEVIPTDLQSKFSAICSEKIERICQRISSYKKFSRVLKNRAWPTFKQAKSRISPLHSSDFCPTNCHVNVMEVSYPKTSTSLGSAFGVQLDSRKHNSHDKENKSEQGKLSPMVYIQHTITTMAAPSGLSLGQQDGHGLRYLLKEEDLETQDIYQKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKASESIVPTDSDNEKGERNSKRVCFNMAGDEQEDSGHDTISNRDSYSDCNSNRNSVASFTSICSSQCSSYFHSDEMDSGDELPLNVRISRDKQDKIHSCLEHLFSQVDSITNLLRGQAVVRAFEQTKYLTPGRGLQEFQQEMEPKLSCPKRLRLHIKQDPWNLPSSVRNLAQNIRRFVEEVKCRILLALLEYSDSETQLRRDMVFCQSLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSPNLTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQALKIYFYIDSYHFEQLPQRLKNGGGFKIHPVLFSQALESMEGYYYRDNVSVEEFQAQINAASLEKVKQYNQKLRAFYLDKSNSPPNSTSKAAYIDKLMRPLNVLDELYRLVASFIRSKRTAACVNTACSASGVGLLSVSSELCSRLGACHVIMCNSGVHRCTLSVTLEQAIILARSHGLPPRYIMQATDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPVGEE", "length": 1553, "header": "tr|E1BDL7-1|E1BDL7_BOVIN Isoform 1 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein OS=Bos taurus OX=9913 GN=PREX2 PE=4 SV=3 CANONICAL=E1BDL7-1" }, "locus": { "chromosome": "14", "start_pos": 32270586, "end_pos": 32049455, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023938.7", "url": "https://www.ensembl.org/id/ENSBTAT00000023938.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023938.6", "url": "https://www.ensembl.org/id/ENSBTAP00000023938.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8948751", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948751", "resource": "Reactome", "description": "Regulation of PTEN stability and activity" }, { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-BTA-9013148", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "E1BDL7", "url": "https://www.uniprot.org/uniprotkb/E1BDL7" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "E1BDL7", "url": "https://www.uniprot.org/uniprotkb/E1BDL7" } ], "pmid": "" }, { "name": "negative regulation of TOR signaling", "id": "GO:0032007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032007", "evidence": [ { "database": "UniProtKB", "id": "E1BDL7", "url": "https://www.uniprot.org/uniprotkb/E1BDL7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "E1BDL7", "url": "https://www.uniprot.org/uniprotkb/E1BDL7" } ], "pmid": "" }, { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "E1BDL7", "url": "https://www.uniprot.org/uniprotkb/E1BDL7" } ], "pmid": "" }, { "name": "protein serine/threonine kinase inhibitor activity", "id": "GO:0030291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030291", "evidence": [ { "database": "UniProtKB", "id": "E1BDL7", "url": "https://www.uniprot.org/uniprotkb/E1BDL7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BDL7", "url": "https://www.uniprot.org/uniprotkb/E1BDL7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1274, "end_pos": 1276, "annotation": "n_glycosylation_sequon" }, { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1370, "end_pos": 1372, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1408, "end_pos": 1410, "annotation": "n_glycosylation_sequon" }, { "start_pos": 186, "end_pos": 188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 674, "end_pos": 676, "annotation": "n_glycosylation_sequon" }, { "start_pos": 814, "end_pos": 816, "annotation": "n_glycosylation_sequon" }, { "start_pos": 922, "end_pos": 924, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDL7" }, { "id": "PS50186", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50186" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DEP", "eco_id": "ECO_0000259", "start_pos": 338, "end_pos": 412, "start_aa": "Cys", "end_aa": "Tyr", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BDL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDL7" }, { "id": "PS50010", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50010" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DH", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 162, "start_aa": "Met", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BDL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDL7" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 540, "end_pos": 589, "start_aa": "Lys", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BDL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDL7" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 193, "end_pos": 309, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1274, 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] }, { "id": "IPR010909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041645", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041645", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045371", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045371", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056270", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056270", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MG57", "url": "https://www.orthodb.org/?gene=A0A3Q1MG57", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B6Z9", "url": "https://www.orthodb.org/?gene=E1B6Z9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13723", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13723", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13723:SF151", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13723:SF151", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00090", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00090", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01421", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01421", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01562", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01562", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05986", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05986", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17771", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17771", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19030", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19030", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19236", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19236", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23178", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23178", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5173214", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5173214", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MG57", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MG57", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MG57-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MG57-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B6Z9", "url": "https://www.uniprot.org/uniprotkb/E1B6Z9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B6Z9-1", "url": "https://www.uniprot.org/uniprotkb/E1B6Z9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"length": 1093, "header": "tr|E1B6Z9-1|E1B6Z9_BOVIN Isoform 1 of ADAM metallopeptidase with thrombospondin type 1 motif 17 OS=Bos taurus OX=9913 GN=ADAMTS17 PE=4 SV=4 CANONICAL=E1B6Z9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MG57-1", "url": "https://www.uniprot.org/uniprotkb/E1B6Z9/entry#A0A3Q1MG57-1", "sequence": { "sequence": 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"length": 1120, "header": "tr|A0A3Q1MG57-1|E1B6Z9_BOVIN Computationally mapped isoform of ADAM metallopeptidase with thrombospondin type 1 motif 17 OS=Bos taurus OX=9913 GN=ADAMTS17 PE=4 SV=2 CANONICAL=E1B6Z9-1" }, "locus": { "chromosome": "21", "start_pos": 6739115, "end_pos": 6331925, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079673.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079673.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073228.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073228.2" } ] } }, { "isoform_ac": "E1B6Z9-1", "url": "https://www.uniprot.org/uniprotkb/E1B6Z9/entry#E1B6Z9-1", "sequence": { "sequence": "MCDGALLPPLALPLLLLLLWGLDPGTAVGDAAADVEVVLPRRVRLEDVHLPPLPGAPGPRRRRRPRAPPAAPRARLGERALLLHLPAFGRDLYLQLRRDLRFLSGGFEVEEAGAGGRHGRSAELCFYSGSVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNSSQGQEHLVRRKWSLTPSPSPKPQIPGQLCKVLTEKKKPRKGRQSRDGRQRRNAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKVNIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDTPPVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRSPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSRHAVRLPHKLPGMHYSANEQCQILFGTNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCLGASVEHTVCENLPCPKGLPSFRDQQCQTHDRLSSKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGRCQKIGCDGIIGSAAKEDRCGVCSGDGKTCRVVKGDFSHARGTALKDSSKRSINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKMPLHLMVLLFHDQNYGIHYEYTIPVNYTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRSIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGIQHREVTCVYQLQNGTHVATRPLYCPVPRPSPVQSCEGQDCLSIWEASEWSQCSASCGKGTQKRTVTCTNSQGKCDASTRPRAEEPCEDYSGCYEWKTGSWSKCSSTCGKGLQSRVVQCMHKVTGRHGNECPALSKPAAYKQCHQEVCNDKINVNTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKMRQPPPPPSS", "length": 1093, "header": "tr|E1B6Z9-1|E1B6Z9_BOVIN Isoform 1 of ADAM metallopeptidase with thrombospondin type 1 motif 17 OS=Bos taurus OX=9913 GN=ADAMTS17 PE=4 SV=4 CANONICAL=E1B6Z9-1" }, "locus": { "chromosome": "21", "start_pos": 6739115, "end_pos": 6331925, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026411.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026411.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026411.7", "url": "https://www.ensembl.org/id/ENSBTAP00000026411.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5173214", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5173214", "resource": "Reactome", "description": "O-glycosylation of TSR domain-containing proteins" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metalloendopeptidase 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"reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRP4", "url": "https://www.uniprot.org/uniprotkb/E1BC34", "locus": {} } ], "crossref": [ { "id": "ENSBTAG00000025304", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025304", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000038718", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038718", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000049075", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049075", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000049869", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049869", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10288", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10288", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001400", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001400", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "SHMEDAP", "url": "https://omabrowser.org/oma/group/SHMEDAP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BC34", "url": "https://www.orthodb.org/?gene=E1BC34", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11417", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11417", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11417:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11417:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00103", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00103", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MJ45", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJ45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJ45-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJ45-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC34", "url": "https://www.uniprot.org/uniprotkb/E1BC34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC34-1", "url": "https://www.uniprot.org/uniprotkb/E1BC34-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G1K1D7", "url": "https://www.uniprot.org/uniprotkb/G1K1D7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G1K1D7-1", "url": "https://www.uniprot.org/uniprotkb/G1K1D7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E550", "url": "https://www.uniprot.org/uniprotkb/G5E550", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E550-1", "url": "https://www.uniprot.org/uniprotkb/G5E550-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASWLSLRSIPCSRFPPSHPIRLTPHGQQESSPWDHSTIPMAPAPSFRGHQWTYNPVRGSCLLLLLLMSNLLLCQGKSCPSCGPDVFVSLRKSFTDRFMNAASLSHDFYNLSTIMFNEFDEKYAQGKLYYINVTKSCHTNSFHAPEERDIVQQTNIEDLSKWTLVLLYSWNNPLHHLVTELQHMKELSNAFLSSATRFENMSEKLQAFIERQFSKIIVPVLNTMIQARSSWTGLPSLMSSDEDRRHSEFYNLFYCLRRDSRKVDMYIKILTCRTHKTC", "length": 278, "header": "tr|E1BC34-1|E1BC34_BOVIN Isoform 1 of Prolactin-related protein 13 OS=Bos taurus OX=9913 GN=PRP4 PE=3 SV=3 CANONICAL=E1BC34-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MJ45-1", "url": "https://www.uniprot.org/uniprotkb/E1BC34/entry#A0A3Q1MJ45-1", "sequence": { "sequence": "LLPHPSFYGSCLLLLLVVSNLVLCQGKSCLSCSPDVFVSLQKSLTDVFVYALSLSHDIHNLSTIMFNEFDEKYAQGKLYHINATKSCHTNSFHTPEEGDKAQQTNNEDLIKWTLVLLYCWNNPLYYLVPEIQSMKNLSEAVVSSAEEIENMSEKLESLIETHFGKIIFPVLKTIHEARIPWSRYSSMKFSNEDRRISEYYNLFYCLRRDSHKVDMYINILECRTRKTC", "length": 228, "header": "tr|A0A3Q1MJ45-1|E1BC34_BOVIN Computationally mapped isoform of Prolactin-related protein 13 OS=Bos taurus OX=9913 GN=PRP4 PE=3 SV=1 CANONICAL=E1BC34-1" }, "locus": { "chromosome": "23", "start_pos": 34927121, "end_pos": 34921831, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083340.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083340.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074359.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074359.1" } ] } }, { "isoform_ac": "E1BC34-1", "url": "https://www.uniprot.org/uniprotkb/E1BC34/entry#E1BC34-1", "sequence": { "sequence": "MASWLSLRSIPCSRFPPSHPIRLTPHGQQESSPWDHSTIPMAPAPSFRGHQWTYNPVRGSCLLLLLLMSNLLLCQGKSCPSCGPDVFVSLRKSFTDRFMNAASLSHDFYNLSTIMFNEFDEKYAQGKLYYINVTKSCHTNSFHAPEERDIVQQTNIEDLSKWTLVLLYSWNNPLHHLVTELQHMKELSNAFLSSATRFENMSEKLQAFIERQFSKIIVPVLNTMIQARSSWTGLPSLMSSDEDRRHSEFYNLFYCLRRDSRKVDMYIKILTCRTHKTC", "length": 278, "header": "tr|E1BC34-1|E1BC34_BOVIN Isoform 1 of Prolactin-related protein 13 OS=Bos taurus OX=9913 GN=PRP4 PE=3 SV=3 CANONICAL=E1BC34-1" }, "locus": { "chromosome": "23", "start_pos": 34777702, "end_pos": 34765723, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048220.5", "url": "https://www.ensembl.org/id/ENSBTAT00000048220.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045299.4", "url": "https://www.ensembl.org/id/ENSBTAP00000045299.4" } ] } }, { "isoform_ac": "G1K1D7-1", "url": "https://www.uniprot.org/uniprotkb/E1BC34/entry#G1K1D7-1", "sequence": { "sequence": "MAPAPSFRGHQWTYNPIRGSCLLLLLVMSNLLLCQGILCPSLCPDGDDVCRASLIDLFVHASVLSTGMYNHSVKMFTDFDEQYAQGKEYFINVSDKCHTNSLHLPEDMQHIRRMNSKGLIMWILMLLYSWQRPLYQLVTDLRSMKEVSNTILSSARENVKKLKELQALIERPFSQVIFTARRKMYIARIYWFGLRSLLSSNEDRRHSAFYSLFFCLRRDTRKLDIYTKFVACRLIYKKC", "length": 239, "header": "tr|G1K1D7-1|E1BC34_BOVIN Computationally mapped isoform of Prolactin-related protein 13 OS=Bos taurus OX=9913 GN=PRP4 PE=3 SV=2 CANONICAL=E1BC34-1" }, "locus": { "chromosome": "23", "start_pos": 34934454, "end_pos": 34592226, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009326.6", "url": "https://www.ensembl.org/id/ENSBTAT00000009326.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009326.6", "url": "https://www.ensembl.org/id/ENSBTAP00000009326.6" } ] } }, { "isoform_ac": "G5E550-1", "url": "https://www.uniprot.org/uniprotkb/E1BC34/entry#G5E550-1", "sequence": { "sequence": 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"OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1BC34", "url": "https://www.uniprot.org/uniprotkb/E1BC34" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BC34", "url": "https://www.uniprot.org/uniprotkb/E1BC34" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BC34", "url": "https://www.uniprot.org/uniprotkb/E1BC34" } ], "pmid": "" }, { "name": "hormone activity", "id": "GO:0005179", "url": 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"name": "response to nutrient levels", "id": "GO:0031667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031667", "evidence": [ { "database": "UniProtKB", "id": "E1BC34", "url": "https://www.uniprot.org/uniprotkb/E1BC34" } ], "pmid": "" }, { "name": "female pregnancy", "id": "GO:0007565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007565", "evidence": [ { "database": "UniProtKB", "id": "E1BC34", "url": "https://www.uniprot.org/uniprotkb/E1BC34" } ], "pmid": "" }, { "name": "positive regulation of receptor signaling pathway via JAK-STAT", "id": "GO:0046427", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046427", "evidence": [ { "database": "UniProtKB", "id": "E1BC34", "url": "https://www.uniprot.org/uniprotkb/E1BC34" } ], "pmid": "" }, { "name": "mammary gland development", "id": "GO:0030879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030879", "evidence": [ { "database": "UniProtKB", "id": "E1BC34", "url": "https://www.uniprot.org/uniprotkb/E1BC34" } ], "pmid": "" }, { "name": "positive regulation of lactation", "id": "GO:1903489", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903489", "evidence": [ { "database": "UniProtKB", "id": "E1BC34", "url": "https://www.uniprot.org/uniprotkb/E1BC34" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" }, { "start_pos": 200, "end_pos": 202, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "E1BC34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC34#function" }, { "id": "E1BC34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC34" }, { "id": "PIRSR601400-1", "database": "PIR 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"categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MPZ5", "url": "https://www.orthodb.org/?gene=A0A3Q1MPZ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B7M8", "url": "https://www.orthodb.org/?gene=E1B7M8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10972", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10972", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10972:SF194", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10972:SF194", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01237", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01237", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179181", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179181", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPZ5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7M8", "url": "https://www.uniprot.org/uniprotkb/E1B7M8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7M8-1", "url": "https://www.uniprot.org/uniprotkb/E1B7M8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKAAALCRGSGCGGRSRGLSSLFTVVPCLSCHTAAPSMNAPTPGSGPEPKPQLQPVPQPQRELVSEQVLEPVSERAPGSEPEPKKMSEPRPGFRQELELLPALGTGSGPREEWGSNPGPGPPTKAPFEQVPALGPAVGSVPLIKPESGLLPASKDPRPGQVKTHLGMAVPRSSSPGVVPMVSLPLDNFKGWLLKWTNYLKGYQRRWFVLSNGLLSYYRNQGEMAHTCRGTINLFTAHFDTEDSCGIVLTSGGRTYHLKAGSEVERQQWITALELAKARAVRMMSNHSDDSGDDEDGTPSPADKSELHSTIKSLSLKLDDLSTCNELVAKHGVALQRSLNELDGLRIPAESSEKLKAVNERATLFRITSNAMINACRDFLELAETHSRKWQRALQYEQEQRVHLEETIEQLAKQHNSLERAFRSAPGRAANPSKSFSEGSLFTSKAEDSEDDEDTEYFDAMEDAASFITVTTEPSEDGKAEAGTAGSVEWTADNVLDGASPVPQGPPKVKRRVRIPDKPNYSLNLWSIMKNCIGRELSKIPMPVNFNEPLSMLQRLTEDLEYHRLLDAAARCGSTVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWSLWQEITIASKFRGKYLSIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQTGDVEIVNHKTKDRCQLKFLPYSYFSKEVARKVTGVVSDSQGKAHYVLSGSWDEQMECAKIVQSSPSSPSSDGKQKTVYQTLPAKLLWKKHPLPDNAENMYYFSELALTLNENEEGVAPTDSRLRPDQRLMEKGHWDEANTEKQRLEEKQRANRRRRLEACSRGCGVDEEKEAEVYVPLWFEKKLDPLTGEMACVYKGGYWEAKERQDWHMCPNIF", "length": 916, "header": "tr|E1B7M8-1|E1B7M8_BOVIN Isoform 1 of Oxysterol-binding protein OS=Bos taurus OX=9913 GN=OSBP2 PE=3 SV=1 CANONICAL=E1B7M8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MPZ5-1", "url": "https://www.uniprot.org/uniprotkb/E1B7M8/entry#A0A3Q1MPZ5-1", "sequence": { "sequence": "MGKAAALCRGSGCGGRSRGLSSLFTVVPCLSCHTAAPSMNAPTPGSGPEPKPQLQPVPQPQRELVSEQVLEPVSERAPGSEPEPKKMSEPRPGFRQELELLPALGTGSGPREEWGSNPGPGPPTKAPFEQVPALGPAVGSVPLIKPESGLLPASKDPRPGQVKTHLGMAVPRSSSPGVVPMVSLPLDNFKGWLLKWTNYLKGYQRRWFVLSNGLLSYYRNQGEMAHTCRGTINLFTAHFDTEDSCGIVLTSGGRTYHLKAGSEVERQQWITALELAKARAVRMMSNHSDDSGDDEDGTPSPADKSELHSTIKSLSLKLDDLSTCNELVAKHGVALQRSLNELDGLRIPAESSEKLKAVNERATLFRITSNAMINACRDFLELAETHSRKWQRALQYEQEQRVHLEETIEQLAKQHNSLERAFRSAPGRAANPSKSFSEGSLFTSKAEDSEDDEDTEYFDAMEDAASFITVTTEPSEDGKAEAGTAGSVEWTADNVLDGASPVPQGPPKVKRRVRIPDKPNYSLNLWSIMKNCIGRELSKIPMPVNFNEPLSMLQRLTEDLEYHRLLDAAARCGSTVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWSLWQEITIASKFRGKYLSIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQTGDVEIVNHKTKDRCQLKFLPYSYFSKEVARKVTGVVSDSQGKAHYVLSGSWDEQMECAKIVQSSPSSPSSDGKQKTVYQTLPAKLLWKKHPLPDNAENMYYFSELALTLNENEEGVAPTDSRLRPDQRLMEKGHWDEANTEKQRLEEKQRANRRRRLEACSRGCGVDEGEPLGEGPAGEGPAGEPRGRPGAGKGWGLLAAGRGQGVAFRGQRRKQAAHRRPAVPPHREGGRSVCATVVREEAGSAHRGNGLRVQGGLLGGQGEAGLAHVPQHLLSSARPADTGARTPLHLLFRALSLALCGPPTPPFPSGLITLFGALTLEGGSADPGSLKPPGAPGLPPAFTMDSGPLGPPAPVPTTQAGWSRPWAASVTSPPGRNRPLPGSHFRVF", "length": 1089, "header": "tr|A0A3Q1MPZ5-1|E1B7M8_BOVIN Computationally mapped isoform of Oxysterol-binding protein OS=Bos taurus OX=9913 GN=OSBP2 PE=3 SV=1 CANONICAL=E1B7M8-1" }, "locus": { "chromosome": "17", "start_pos": 69792453, "end_pos": 69639874, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085060.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085060.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073611.1", "url": "https://www.ensembl.org/id/ENSBTAP00000073611.1" } ] } }, { "isoform_ac": "E1B7M8-1", "url": "https://www.uniprot.org/uniprotkb/E1B7M8/entry#E1B7M8-1", "sequence": { "sequence": "MGKAAALCRGSGCGGRSRGLSSLFTVVPCLSCHTAAPSMNAPTPGSGPEPKPQLQPVPQPQRELVSEQVLEPVSERAPGSEPEPKKMSEPRPGFRQELELLPALGTGSGPREEWGSNPGPGPPTKAPFEQVPALGPAVGSVPLIKPESGLLPASKDPRPGQVKTHLGMAVPRSSSPGVVPMVSLPLDNFKGWLLKWTNYLKGYQRRWFVLSNGLLSYYRNQGEMAHTCRGTINLFTAHFDTEDSCGIVLTSGGRTYHLKAGSEVERQQWITALELAKARAVRMMSNHSDDSGDDEDGTPSPADKSELHSTIKSLSLKLDDLSTCNELVAKHGVALQRSLNELDGLRIPAESSEKLKAVNERATLFRITSNAMINACRDFLELAETHSRKWQRALQYEQEQRVHLEETIEQLAKQHNSLERAFRSAPGRAANPSKSFSEGSLFTSKAEDSEDDEDTEYFDAMEDAASFITVTTEPSEDGKAEAGTAGSVEWTADNVLDGASPVPQGPPKVKRRVRIPDKPNYSLNLWSIMKNCIGRELSKIPMPVNFNEPLSMLQRLTEDLEYHRLLDAAARCGSTVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWSLWQEITIASKFRGKYLSIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQTGDVEIVNHKTKDRCQLKFLPYSYFSKEVARKVTGVVSDSQGKAHYVLSGSWDEQMECAKIVQSSPSSPSSDGKQKTVYQTLPAKLLWKKHPLPDNAENMYYFSELALTLNENEEGVAPTDSRLRPDQRLMEKGHWDEANTEKQRLEEKQRANRRRRLEACSRGCGVDEEKEAEVYVPLWFEKKLDPLTGEMACVYKGGYWEAKERQDWHMCPNIF", "length": 916, "header": "tr|E1B7M8-1|E1B7M8_BOVIN Isoform 1 of Oxysterol-binding protein OS=Bos taurus OX=9913 GN=OSBP2 PE=3 SV=1 CANONICAL=E1B7M8-1" }, "locus": { "chromosome": "17", "start_pos": 69792109, "end_pos": 69639874, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078191.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078191.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067183.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067183.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 43, "start_aa": "Thr", "end_pos": 43, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr43", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 820, "start_aa": "Thr", "end_pos": 820, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr820", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:510311", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510311", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B7M8", "url": "https://www.uniprot.org/uniprotkb/E1B7M8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B7M8", "url": "https://www.uniprot.org/uniprotkb/E1B7M8" } ], "pmid": "" }, { "name": "perinuclear endoplasmic reticulum", "id": "GO:0097038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097038", "evidence": [ { "database": "UniProtKB", "id": "E1B7M8", "url": "https://www.uniprot.org/uniprotkb/E1B7M8" } ], "pmid": "" }, { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "E1B7M8", "url": "https://www.uniprot.org/uniprotkb/E1B7M8" } ], "pmid": "" }, { "name": "apical dendrite", "id": "GO:0097440", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097440", "evidence": [ { "database": "UniProtKB", "id": "E1B7M8", "url": "https://www.uniprot.org/uniprotkb/E1B7M8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1B7M8", "url": "https://www.uniprot.org/uniprotkb/E1B7M8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "E1B7M8", "url": "https://www.uniprot.org/uniprotkb/E1B7M8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "cholesterol binding", "id": "GO:0015485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015485", "evidence": [ { "database": "UniProtKB", "id": "E1B7M8", "url": "https://www.uniprot.org/uniprotkb/E1B7M8" } ], "pmid": "" }, { "name": "sterol binding", "id": "GO:0032934", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032934", "evidence": [ { "database": "UniProtKB", "id": "E1B7M8", "url": "https://www.uniprot.org/uniprotkb/E1B7M8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 286, "end_pos": 288, "annotation": "n_glycosylation_sequon" }, { "start_pos": 520, "end_pos": 522, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7M8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7M8" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 186, "end_pos": 278, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 43, 820 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 286, "end_pos": 288 }, { "start_pos": 520, "end_pos": 522 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B9G4-1", "uniprot_ac": "E1B9G4", "uniprot_id": "E1B9G4_BOVIN", "mass": { "chemical_mass": 18128.0, "monoisotopic_mass": 18128.0 }, "refseq": { "ac": "NP_001193493", "name": "peptidyl-prolyl cis-trans isomerase-like 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193493" }, "gene_names": [ { "name": "PPIL3", "type": "recommended", "evidence": [ { "id": "E1B9G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9G4" } ] }, { "name": "PPIL3", "type": "synonym", "evidence": [ { "id": "NP_001193493", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193493" } ] } ], "protein_names": [ { "name": "Peptidyl-prolyl cis-trans isomerase", "type": "recommended", "evidence": [ { "id": "E1B9G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9G4/entry#names_and_taxonomy" } ] }, { "name": "5.2.1.8", "type": "synonym", "evidence": [ { "id": "E1B9G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9G4/entry#names_and_taxonomy" } ] }, { "name": "PPIase", "type": "synonym", "evidence": [ { "id": "E1B9G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9G4/entry#names_and_taxonomy" } ] }, { "name": "peptidyl-prolyl cis-trans isomerase-like 3", "type": "synonym", "evidence": [ { "id": "NP_001193493", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193493" } ] }, { "name": "peptidylprolyl isomerase (cyclophilin)-like 3", "type": "synonym", "evidence": [ { "id": "NP_001193493", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193493" } ] } ], "function": [ { "annotation": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.", "evidence": [ { "database": "UniProtKB", "id": "E1B9G4", "url": "https://www.uniprot.org/uniprotkb/E1B9G4#function" }, { "database": "UniProtKB", "id": "ARBA00058414", "url": "https://www.uniprot.org/uniprotkb/ARBA00058414#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9G4", "url": "https://www.uniprot.org/uniprotkb/E1B9G4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPIL3", "url": "https://www.uniprot.org/uniprotkb/E1B9G4", "locus": { "chromosome": "2", "start_pos": 89520665, "end_pos": 89531010, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005416", "url": "https://www.ensembl.org/id/ENSBTAG00000005416" } ] } } ], "crossref": [ { "id": "E1B9G4", "url": "https://alphafold.ebi.ac.uk/entry/E1B9G4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005416", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005416", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01928", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01928", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615703", "url": "https://www.ncbi.nlm.nih.gov/gene/615703", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615703", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615703", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VPFHRVM", "url": "https://omabrowser.org/oma/group/VPFHRVM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B9G4", "url": "https://www.orthodb.org/?gene=E1B9G4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45625", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45625", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45625:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45625:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00160", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00160", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193493", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16237", "url": "https://www.rhea-db.org/rhea/16237", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TWJ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWJ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWJ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWJ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9G4", "url": "https://www.uniprot.org/uniprotkb/E1B9G4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9G4-1", "url": "https://www.uniprot.org/uniprotkb/E1B9G4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVTLHTDVGDIKIEVFCERTPKTCENFLALCASNYYNGCIFHRNIKGFMVQTGDPTGTGRGGNSIWGKKFEDEYSEYLKHSVRGVVSMANNGPNTNGSQFFITYGKQPHLDMKYTVFGKVIDGLETLDELEKLPVNEKTYRPLNDVHIKDITIHANPFAQ", "length": 161, "header": "tr|E1B9G4-1|E1B9G4_BOVIN Isoform 1 of Peptidyl-prolyl cis-trans isomerase OS=Bos taurus OX=9913 GN=PPIL3 PE=3 SV=3 CANONICAL=E1B9G4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TWJ7-1", "url": "https://www.uniprot.org/uniprotkb/E1B9G4/entry#A0AAA9TWJ7-1", "sequence": { "sequence": "MKRAGCKAVNLRVRAPAPLEPYPISRQPGFLRLSLPCGYQGAATAHHRRLSYPRRNLILPRLTSPGTPQELLPVLSGTSWCCESRRDAGAGRKRISWLFVPVITTTAVYFIEISRVSWFKREIQQHSVRGVVSMANNGPNTNGSQFFITYGKQPHLDMKYTVFGKVIDGLETLDELEKLPVNEKTYRPLNDVHIKDITIHANPFAQ", "length": 206, "header": "tr|A0AAA9TWJ7-1|E1B9G4_BOVIN Computationally mapped isoform of Peptidyl-prolyl cis-trans isomerase OS=Bos taurus OX=9913 GN=PPIL3 PE=3 SV=1 CANONICAL=E1B9G4-1" }, "locus": { "chromosome": "2", "start_pos": 89530811, "end_pos": 89520928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131483.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131483.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103025.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103025.1" } ] } }, { "isoform_ac": "E1B9G4-1", "url": "https://www.uniprot.org/uniprotkb/E1B9G4/entry#E1B9G4-1", "sequence": { "sequence": "MSVTLHTDVGDIKIEVFCERTPKTCENFLALCASNYYNGCIFHRNIKGFMVQTGDPTGTGRGGNSIWGKKFEDEYSEYLKHSVRGVVSMANNGPNTNGSQFFITYGKQPHLDMKYTVFGKVIDGLETLDELEKLPVNEKTYRPLNDVHIKDITIHANPFAQ", "length": 161, "header": "tr|E1B9G4-1|E1B9G4_BOVIN Isoform 1 of Peptidyl-prolyl cis-trans isomerase OS=Bos taurus OX=9913 GN=PPIL3 PE=3 SV=3 CANONICAL=E1B9G4-1" }, "locus": { "chromosome": "2", "start_pos": 89529619, "end_pos": 89520928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007126.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007126.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007126.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007126.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:615703", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615703", "resource": "KEGG Pathway" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7FBJ9-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase", "gene_name": "Ppil3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKLGGSGPVRFASDSRDLHEVARTAAGFLEPSRGRMSVTLHTDVGDIKIEVFCERTPKTCENFLALCASNYYNGCVFHRNIKGFMVQTGDPTGTGRGGSSIWGKKFEDEYSEYLKHNVRGVVSMANNGPNTNGSQFFITYGKQPHLDMKYTVFGKVIDGLETLDELEKLPVNEKTYRPLNDVHIKDITIHANPFAQ", "length": 196 }, "evidence": [ { "id": "E1B9G4", "url": "https://omabrowser.org/oma/group/E1B9G4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F2Z5T7-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase", "gene_name": "PPIL3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSVTLHTDVGDIKIEVFCERTPKTCENFLALCASNYYNGCIFHRNIKGFMVQTGDPTGTGRGGNSIWGKKFEDEYSEYLKHNVRGVVSMANNGPNTNGSQFFITYGKQPHLDMKYTVFGKVIDGLETLDELEKLPVNEKTYRPLNDVHIKDITIHANPFAQ", "length": 161 }, "evidence": [ { "id": "E1B9G4", "url": "https://omabrowser.org/oma/group/E1B9G4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q54E95-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase-like 3", "gene_name": "ppil3", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSVTLHTSLGDIKVEIFCDSVPLASENFLALCASNYYNNTIFHRNIKGFMIQGGDPTNTGRGGESIWKKQFKDEFPSHLKHNTRGILSMANSGPDTNGSQFFITYGKHRSLNKVYTVFGKIIAGIEVLDLMEKVPVDDKDLPLNEIILKSVTIHANPIANQ", "length": 161 }, "evidence": [ { "id": "E1B9G4", "url": "https://omabrowser.org/oma/group/E1B9G4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5ZLV2-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase-like 3", "gene_name": "PPIL3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAVTLHTDVGDIKIELFCERTPKTCENFLALCASNYYNGCVFHRNIKGFMVQTGDPLGTGKGGTSIWGKKFEDEFSEYLKHSVRGVVSMANNGPNTNGSQFFITYGKQPHLDMKYTVFGKVIDGLETLDELEKLPVNEKTYRPLNDVHIKDITIHANPFAL", "length": 161 }, "evidence": [ { "id": "E1B9G4", "url": "https://omabrowser.org/oma/group/E1B9G4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q812D3-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase-like 3", "gene_name": "Ppil3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSVTLHTDVGDIKIEVFCERTPKTCENFLALCASNYYNGCVFHRNIKGFMVQTGDPTGTGRGGSSIWGKKFEDEYSEYLKHNVRGVVSMANNGPNTNGSQFFITYGKQPHLDMKYTVFGKVIDGLETLDELEKLPVNEKTYRPLNDVHIKDITIHANPFAQ", "length": 161 }, "evidence": [ { "id": "E1B9G4", "url": "https://omabrowser.org/oma/group/E1B9G4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D6L8-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase-like 3", "gene_name": "Ppil3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVTLHTDVGDIKIEVFCERTPKTCENFLALCASNYYNGCVFHRNIKGFMVQTGDPTGTGRGGSSIWAKKFEDEYSEYLKHNVRGVVSMANNGPNTNGSQFFITYGKQPHLDMKYTVFGKVIDGLETLDELEKLPVNEKTYRPLNDVHIKDITIHANPFAQ", "length": 161 }, "evidence": [ { "id": "E1B9G4", "url": "https://omabrowser.org/oma/group/E1B9G4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H2H8-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase-like 3", "gene_name": "PPIL3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSVTLHTDVGDIKIEVFCERTPKTCENFLALCASNYYNGCIFHRNIKGFMVQTGDPTGTGRGGNSIWGKKFEDEYSEYLKHNVRGVVSMANNGPNTNGSQFFITYGKQPHLDMKYTVFGKVIDGLETLDELEKLPVNEKTYRPLNDVHIKDITIHANPFAQ", "length": 161 }, "evidence": [ { "id": "E1B9G4", "url": "https://omabrowser.org/oma/group/E1B9G4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9LPC7-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase CYP18-1", "gene_name": "CYP18-1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSVTLHTNLGDIKCEIFCDEVPKSAENFLALCASGYYDGTIFHRNIKGFMIQGGDPKGTGKGGTSIWGKKFNDEIRDSLKHNARGMLSMANSGPNTNGSQFFITYAKQPHLNGLYTIFGKVIHGFEVLDIMEKTQTGPGDRPLAEIRLNRVTIHANPLAG", "length": 160 }, "evidence": [ { "id": "E1B9G4", "url": "https://omabrowser.org/oma/group/E1B9G4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "peptidyl-prolyl cis-trans isomerase activity", "id": "GO:0003755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003755", "evidence": [ { "database": "UniProtKB", "id": "E1B9G4", "url": "https://www.uniprot.org/uniprotkb/E1B9G4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "E1B9G4", "url": "https://www.uniprot.org/uniprotkb/E1B9G4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "catalytic step 2 spliceosome", "id": "GO:0071013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071013", "evidence": [ { "database": "UniProtKB", "id": "E1B9G4", "url": "https://www.uniprot.org/uniprotkb/E1B9G4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16237", "name": "", "equation": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M4A4-1", "P18203-1", "Q5BIN5-1", "A6QPY8-1", "F1N4S5-1", "F1N6W2-1", "G3X8B1-1", "A0A3Q1LI03-1", "A0AAA9TG77-1", "F1MNW5-1", "E1B9G4-1", "G3MXV0-1", "Q2KJC8-1", "A0AAF6YJC8-1", "A0AAF6YJR2-1", "P26882-1", "F6RD06-1", "Q32PA9-1", "Q0P5D0-1", "Q2KJ44-1", "Q2HJ89-1", "Q08E11-1", "Q9TRY0-1", "A0A3Q1LK42-1", "A4FV72-1", "P26884-1", "P30404-1", "P62935-1", "P68107-1", "Q29RZ2-1", "P80311-1", "A0AAA9RV00-1", "F1MU79-1", "A0A3Q1LJJ1-1", "Q5E992-1", "Q2YDL5-1", "A0AAA9U018-1", "A0ABI0NKM5-1", "A0ABI0NMT7-1", "A0A3Q1LSB7-1" ], "evidence": [ { "id": "16237", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16237" } ] }, { "id": "R-BTA-9770141", "name": "Formation of the Spliceosomal C* complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-5688092", "R-BTA-5688093", "R-BTA-72073", "R-BTA-9769591", "R-BTA-9769593", "R-BTA-9769594", "R-BTA-9769596", "R-BTA-9769598", "R-BTA-9769599", "R-BTA-9769601" ], "output_participant_list": [ "R-BTA-72060", "R-BTA-8867898", "R-BTA-9770419", "R-BTA-9770425", "R-BTA-9770427", "R-BTA-9770428", "R-BTA-9770430" ], "enzyme_list": [ "P19120-1", "A5PJW8-1", "G3MZY8-1", "Q17R09-1", "Q29RZ2-1", "A0AAA9RV00-1", "Q08E38-1", "Q2NL22-1", "E1BH78-1", "F1MEM4-1", "F1N6W2-1", "A0A3Q1MR43-1", "A0A3Q1M155-1", "Q3T147-1", "Q5E992-1", "E1B9G4-1", "E1BDN4-1" ], "evidence": [ { "id": "R-BTA-9770141", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770141" } ] }, { "id": "R-BTA-9770145", "name": "Formation of the Spliceosomal Bact complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-8849149", "R-BTA-8850837", "R-BTA-8850839", "R-BTA-8865956", "R-BTA-8867885", "R-BTA-8867892", "R-BTA-8952110", "R-BTA-9769561", "R-BTA-9769562", "R-BTA-9769563" ], "output_participant_list": [ "R-BTA-3246027", "R-BTA-53517", "R-BTA-71875", "R-BTA-71881", "R-BTA-8867887", "R-BTA-8867889", "R-BTA-8867895", "R-BTA-8867897", "R-BTA-9770239", "R-BTA-9770248", "R-BTA-9770255", "R-BTA-9770259" ], "enzyme_list": [ "P19120-1", "A5PJW8-1", "G3MZY8-1", "Q0P5D0-1", "A0AAA9RV00-1", "Q08E38-1", "Q28141-1", "Q2NL22-1", "E1BF68-1", "E1BH78-1", "A0A3Q1MR43-1", "A0A3Q1M155-1", "Q3T147-1", "Q5E992-1", "E1B9G4-1" ], "evidence": [ { "id": "R-BTA-9770145", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770145" } ] }, { "id": "R-BTA-9770236", "name": "Formation of the Spliceosomal P complex and exon ligation", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-9769588", "R-BTA-9769590", "R-BTA-9769602" ], "output_participant_list": [ "R-BTA-6791189", "R-BTA-8849139", "R-BTA-8952113" ], "enzyme_list": [ "P19120-1", "A5PJW8-1", "G3MZY8-1", "Q29RZ2-1", "A0AAA9RV00-1", "Q08E38-1", "Q2NL22-1", "E1BH78-1", "F1MEM4-1", "F1N6W2-1", "A0A3Q1MR43-1", "A0A3Q1M155-1", "Q3T147-1", "Q5E992-1", "E1B9G4-1" ], "evidence": [ { "id": "R-BTA-9770236", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770236" } ] }, { "id": "R-BTA-9770847", "name": "Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-5688097", "R-BTA-8869310", "R-BTA-8869311", "R-BTA-9770846" ], "output_participant_list": [ "R-BTA-6814858", "R-BTA-8865888", "R-BTA-8867893", "R-BTA-9769592" ], "enzyme_list": [ "P19120-1", "A5PJW8-1", "G3MZY8-1", "Q29RZ2-1", "A0AAA9RV00-1", "Q08E38-1", "Q2NL22-1", "E1BH78-1", "F1MEM4-1", "A0A3Q1MR43-1", "A0A3Q1M155-1", "Q5E992-1", "E1B9G4-1" ], "evidence": [ { "id": "R-BTA-9770847", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770847" } ] }, { "id": "R-BTA-9794542", "name": "Formation of the Spliceosomal C complex containing intron lariat", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P19120-1", "A5PJW8-1", "G3MZY8-1", "Q17R09-1", "Q29RZ2-1", "A0AAA9RV00-1", "Q08E38-1", "Q2NL22-1", "E1BH78-1", "F1N6W2-1", "A0A3Q1MR43-1", "A0A3Q1M155-1", "Q3T147-1", "Q5E992-1", "E1B9G4-1", "E1BDN4-1" ], "evidence": [ { "id": "R-BTA-9794542", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9794542" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-3246027", "participant_name": "TCERG1 [nucleoplasm]", "crossref": [ { "id": "ENSBTAT00000067382", "database": "ENSEMBL", "url": "" }, { "id": "35685", "database": "VGNC", "url": "" }, { "id": "ENSBTAG00000003259", "database": "ENSEMBL", "url": "" }, { "id": "A0A3Q1NC33", "database": "UniProt", "url": "" }, { "id": "XP_005209676.2", "database": "RefSeq", "url": "" }, { "id": "ENSBTAP00000068923", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-53517", "participant_name": "DHX9 [nucleoplasm]", "crossref": [ { "id": "NP_776461.1", "database": "RefSeq", "url": "" }, { "id": "Q28141", "database": "UniProt", "url": "" }, { "id": "28060", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-5688092", "participant_name": "DHX8 [nucleoplasm]", "crossref": [ { "id": "F1MEM4", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000008339", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000010976", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000010976", "database": "ENSEMBL", "url": "" }, { "id": "NP_001193020.2", "database": "RefSeq", "url": "" }, { "id": "28059", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-5688093", "participant_name": "PRPF18 [nucleoplasm]", "crossref": [ { "id": "Q2HJ41", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000017244", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000022912", 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"Ensembl Gene", "id": "ENSBTAG00000015238", "url": "https://www.ensembl.org/id/ENSBTAG00000015238" } ] } } ], "crossref": [ { "id": "E1BB21", "url": "https://alphafold.ebi.ac.uk/entry/E1BB21", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015238", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015238", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "281129", "url": "https://www.ncbi.nlm.nih.gov/gene/281129", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000233", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000233", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014868", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014868", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281129", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281129", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BB21", "url": "https://www.orthodb.org/?gene=E1BB21", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N5L6", "url": "https://www.orthodb.org/?gene=F1N5L6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24025", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24025", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24025:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24025:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01049", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01049", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08758", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08758", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6805567", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6809371", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005224013", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224013", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BB21", "url": "https://www.uniprot.org/uniprotkb/E1BB21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB21-1", "url": "https://www.uniprot.org/uniprotkb/E1BB21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MXJ3", "url": "https://www.uniprot.org/uniprotkb/F1MXJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MXJ3-1", "url": "https://www.uniprot.org/uniprotkb/F1MXJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5L6", "url": "https://www.uniprot.org/uniprotkb/F1N5L6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N5L6-1", "url": "https://www.uniprot.org/uniprotkb/F1N5L6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPRLRSSLRGALCRQLLLTLVVFSFACEACKKEIFNIPSKLEADKMIGRVNLKECLGSVDRIQSSDPDFRVLEDGSVYTAHAVVLSDEKRSFTIWLSDTKKRTQKEILVLLEYQKKVLKKRHAKETVLRRSKRRWAPIPCSMQENSLGPFPLFLQQVQSDAAQNYTIFYSISGRGVDKEPLNLFFIERDTGNLYCTQPVDREEYDVFDLIAYASTADGYSADFPLPLPIRVEDENDNHPIFTEAVYNFEVPESSRVGTTVGVVCATDRDEPDTMHTRLKYSILEQTPRSPGLFSVHPSTGVITTVSHYLDREVADKYSLIMKVQDMDGQFFGLMSTATCIITVKDSNDNLPTFRQNAYEASVEENTVNVEILRIPVEDKDLINTANWRANFTILKGNENGHFKITTDKATNEGVLSVVKPLDYEESHQVVLEIGVANEAPFTRDVALRMTTMNRAVVTVHVKDQDEGPECSPEVQYIRIKENSAVGSKISGYKAYDPETKSSSGLRYKILHDPKEWITVNEGSGSLETYKTLDREVITPKNDLYNITVLAIDQDGRSCTGTLAVSIEDVNDNPPEILQDYLVICKGNMDYVDISAIDHDSSINGAPFYFSLANTSPEINRLWTITRVNDTAARLAYQKNAQFQEYFIPVAVKDRAGLSATKTLRVNLCDCTNPVQCRAAARSADVILGKWAILAILLGIALLFSILLTLVCGIVSARNKKAFPDDLAQQNLIISNTEAPGDDKVCSANGFMTQTVNNANQGFCGTMGSGVKNGGQESIEMVKGGQQTLESCRGAGHHHTLDSCRGGTIEVENSRYTYSEWQNFTQPRLGEKLHLCNQDEEHMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEAKFAALAETCTKR", "length": 897, "header": "tr|E1BB21-1|E1BB21_BOVIN Isoform 1 of Desmocollin 3 OS=Bos taurus OX=9913 GN=DSC3 PE=4 SV=3 CANONICAL=E1BB21-1" }, "isoforms": [ { "isoform_ac": "E1BB21-1", "url": "https://www.uniprot.org/uniprotkb/E1BB21/entry#E1BB21-1", "sequence": { "sequence": "MAAPRLRSSLRGALCRQLLLTLVVFSFACEACKKEIFNIPSKLEADKMIGRVNLKECLGSVDRIQSSDPDFRVLEDGSVYTAHAVVLSDEKRSFTIWLSDTKKRTQKEILVLLEYQKKVLKKRHAKETVLRRSKRRWAPIPCSMQENSLGPFPLFLQQVQSDAAQNYTIFYSISGRGVDKEPLNLFFIERDTGNLYCTQPVDREEYDVFDLIAYASTADGYSADFPLPLPIRVEDENDNHPIFTEAVYNFEVPESSRVGTTVGVVCATDRDEPDTMHTRLKYSILEQTPRSPGLFSVHPSTGVITTVSHYLDREVADKYSLIMKVQDMDGQFFGLMSTATCIITVKDSNDNLPTFRQNAYEASVEENTVNVEILRIPVEDKDLINTANWRANFTILKGNENGHFKITTDKATNEGVLSVVKPLDYEESHQVVLEIGVANEAPFTRDVALRMTTMNRAVVTVHVKDQDEGPECSPEVQYIRIKENSAVGSKISGYKAYDPETKSSSGLRYKILHDPKEWITVNEGSGSLETYKTLDREVITPKNDLYNITVLAIDQDGRSCTGTLAVSIEDVNDNPPEILQDYLVICKGNMDYVDISAIDHDSSINGAPFYFSLANTSPEINRLWTITRVNDTAARLAYQKNAQFQEYFIPVAVKDRAGLSATKTLRVNLCDCTNPVQCRAAARSADVILGKWAILAILLGIALLFSILLTLVCGIVSARNKKAFPDDLAQQNLIISNTEAPGDDKVCSANGFMTQTVNNANQGFCGTMGSGVKNGGQESIEMVKGGQQTLESCRGAGHHHTLDSCRGGTIEVENSRYTYSEWQNFTQPRLGEKLHLCNQDEEHMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEAKFAALAETCTKR", "length": 897, "header": "tr|E1BB21-1|E1BB21_BOVIN Isoform 1 of Desmocollin 3 OS=Bos taurus OX=9913 GN=DSC3 PE=4 SV=3 CANONICAL=E1BB21-1" }, "locus": { "chromosome": "24", "start_pos": 26134538, "end_pos": 26083500, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048309.5", "url": "https://www.ensembl.org/id/ENSBTAT00000048309.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045372.3", "url": "https://www.ensembl.org/id/ENSBTAP00000045372.3" } ] } }, { "isoform_ac": "F1MXJ3-1", "url": "https://www.uniprot.org/uniprotkb/E1BB21/entry#F1MXJ3-1", "sequence": { "sequence": "MAAPRLRSSLRGALCRQLLLTLVVFSFACEACKKEIFNIPSKLEADKMIGRVNLKECLGSVDRIQSSDPDFRVLEDGSVYTAHAVVLSDEKRSFTIWLSDTKKRTQKEILVLLEYQKKVLKKRHAKETVLRRSKRRWAPIPCSMQENSLGPFPLFLQQVQSDAAQNYTIFYSISGRGVDKEPLNLFFIERDTGNLYCTQPVDREEYDVFDLIAYASTADGYSADFPLPLPIRVEDENDNHPIFTEAVYNFEVPESSRVGTTVGVVCATDRDEPDTMHTRLKYSILEQTPRSPGLFSVHPSTGVITTVSHYLDREVADKYSLIMKVQDMDGQFFGLMSTATCIITVKDSNDNLPTFRQNAYEASVEENTVNVEILRIPVEDKDLINTANWRANFTILKGNENGHFKITTDKATNEGVLSVVKPLDYEESHQVVLEIGVANEAPFTRDVALRMTTMNRAVVTVHVKDQDEGPECSPEVQYIRIKENSAVGSKISGYKAYDPETKSSSGLRYKILHDPKEWITVNEGSGSLETYKTLDREVITPKNDLYNITVLAIDQDGRSCTGTLAVSIEDVNDNPPEILQDYLVICKGNMDYVDISAIDHDSSINGAPFYFSLANTSPEINRLWTITRVNDTAARLAYQKNAQFQEYFIPVAVKDRAGLSATKTLRVNLCDCTNPVQCRAAARSADVILGKWAILAILLGIALLFSILLTLVCGIVSARNKKAFPDDLAQQNLIISNTEAPGDDKVCSANGFMTQTVNNANQGFCGTMGSGVKNGGQESIEMVKGGQQTLESCRGAGHHHTLDSCRGGTIEVENSRYTYSEWQNFTQPRLGEESIRGHTG", "length": 840, "header": "tr|F1MXJ3-1|E1BB21_BOVIN Computationally mapped isoform of Desmocollin 3 OS=Bos taurus OX=9913 GN=DSC3 PE=4 SV=4 CANONICAL=E1BB21-1" }, "locus": { "chromosome": "24", "start_pos": 26134242, "end_pos": 26083500, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020274.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020274.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020274.6", "url": "https://www.ensembl.org/id/ENSBTAP00000020274.6" } ] } }, { "isoform_ac": "F1N5L6-1", "url": "https://www.uniprot.org/uniprotkb/E1BB21/entry#F1N5L6-1", "sequence": { "sequence": "MCNTRSYYLKIETILLLLSQSGCLLLCVCVCVCVFSFACEACKKEIFNIPSKLEADKMIGRVNLKECLGSVDRIQSSDPDFRVLEDGSVYTAHAVVLSDEKRSFTIWLSDTKKRTQKEILVLLEYQKKVLKKRHAKETVLRRSKRRWAPIPCSMQENSLGPFPLFLQQVQSDAAQNYTIFYSISGRGVDKEPLNLFFIERDTGNLYCTQPVDREEYDVFDLIAYASTADGYSADFPLPLPIRVEDENDNHPIFTEAVYNFEVPESSRVGTTVGVVCATDRDEPDTMHTRLKYSILEQTPRSPGLFSVHPSTGVITTVSHYLDREVADKYSLIMKVQDMDGQFFGLMSTATCIITVKDSNDNLPTFRQNAYEASVEENTVNVEILRIPVEDKDLINTANWRANFTILKGNENGHFKITTDKATNEGVLSVVKPLDYEESHQVVLEIGVANEAPFTRDVALRMTTMNRAVVTVHVKDQDEGPECSPEVQYIRIKENSAVGSKISGYKAYDPETKSSSGLRYKILHDPKEWITVNEGSGSLETYKTLDREVITPKNDLYNITVLAIDQDGRSCTGTLAVSIEDVNDNPPEILQDYLVICKGNMDYVDISAIDHDSSINGAPFYFSLANTSPEINRLWTITRVNDTAARLAYQKNAQFQEYFIPVAVKDRAGLSATKTLRVNLCDCTNPVQCRAAARSADVILGKWAILAILLGIALLFSILLTLVCGIVSARNKKAFPDDLAQQNLIISNTEAPGDDKVCSANGFMTQTVNNANQGFCGTMGSGVKNGGQESIEMVKGGQQTLESCRGAGHHHTLDSCRGGTIEVENSRYTYSEWQNFTQPRLGEKLHLCNQDEEHMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEAKFAALAETCTKR", "length": 907, "header": "tr|F1N5L6-1|E1BB21_BOVIN Computationally mapped isoform of Desmocollin 3 OS=Bos taurus OX=9913 GN=DSC3 PE=4 SV=4 CANONICAL=E1BB21-1" }, "locus": { "chromosome": "24", "start_pos": 26134538, "end_pos": 26090259, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048327.6", "url": "https://www.ensembl.org/id/ENSBTAT00000048327.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045387.5", "url": "https://www.ensembl.org/id/ENSBTAP00000045387.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:281129", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281129", "resource": "KEGG Pathway" }, { "id": "R-BTA-6805567", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "resource": "Reactome", "description": "Keratinization" }, { "id": "R-BTA-6809371", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "resource": "Reactome", "description": "Formation of the cornified envelope" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1BB21", "url": "https://www.uniprot.org/uniprotkb/E1BB21" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BB21", "url": "https://www.uniprot.org/uniprotkb/E1BB21" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BB21", "url": "https://www.uniprot.org/uniprotkb/E1BB21" } ], "pmid": "" }, { "name": "desmosome", "id": "GO:0030057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030057", "evidence": [ { "database": "UniProtKB", "id": "E1BB21", "url": "https://www.uniprot.org/uniprotkb/E1BB21" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "E1BB21", "url": "https://www.uniprot.org/uniprotkb/E1BB21" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "E1BB21", "url": "https://www.uniprot.org/uniprotkb/E1BB21" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "E1BB21", "url": "https://www.uniprot.org/uniprotkb/E1BB21" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 392, "end_pos": 394, "annotation": "n_glycosylation_sequon" }, { "start_pos": 547, "end_pos": 549, "annotation": "n_glycosylation_sequon" }, { "start_pos": 615, "end_pos": 617, "annotation": "n_glycosylation_sequon" }, { "start_pos": 630, "end_pos": 632, "annotation": "n_glycosylation_sequon" }, { "start_pos": 824, "end_pos": 826, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BB21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB21" }, { "id": "PS50268", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50268" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cadherin", "eco_id": "ECO_0000259", "start_pos": 136, "end_pos": 243, "start_aa": "Arg", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 166, "end_pos": 168 }, { "start_pos": 392, "end_pos": 394 }, { "start_pos": 547, "end_pos": 549 }, { "start_pos": 615, "end_pos": 617 }, { "start_pos": 630, "end_pos": 632 }, { "start_pos": 824, "end_pos": 826 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", 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"phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BD88-1", "uniprot_ac": "E1BD88", "uniprot_id": "E1BD88_BOVIN", "mass": { "chemical_mass": 29588.0, "monoisotopic_mass": 29588.0 }, "refseq": { "ac": "NP_001179750", "name": "spindlin-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179750" }, "gene_names": [ { "name": "SPIN1", "type": 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} }, { "isoform_ac": "E1BD88-1", "url": "https://www.uniprot.org/uniprotkb/E1BD88/entry#E1BD88-1", "sequence": { "sequence": "MKTPFGKTPGQRSRADAGHAGVSASMMKKRTSHKKHRSSVGPSKPVSQPRRNIVGCRIQHGWKEGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEVLPDRVATSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPIMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQVEYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS", "length": 262, "header": "tr|E1BD88-1|E1BD88_BOVIN Isoform 1 of Spindlin 1 OS=Bos taurus OX=9913 GN=SPIN1 PE=3 SV=2 CANONICAL=E1BD88-1" }, "locus": { "chromosome": "8", "start_pos": 89697253, "end_pos": 89652208, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003961.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003961.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003961.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003961.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:541068", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541068", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZUJ2-1", "protein_name": "Spindlin 1", "gene_name": "SPIN1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKTPFGKTPGQRSRADAGHAGVSASMMKKRTSHKKHRSSVGPSKPVSQPRRNIVGCRIQHGWKEGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEVLPDRVATSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPIMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQVEYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS", "length": 262 }, "evidence": [ { "id": "E1BD88", "url": "https://omabrowser.org/oma/group/E1BD88/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3IF87-1", "protein_name": "Spindlin-1", "gene_name": "Spin1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKTPFGKTPGQRSRADAGHAGVSANMMKKRTSHKKHRTSVGPSKPVSQPRRNIVGCRIQHGWREGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEVLPDRVATSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPVMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQVEYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS", "length": 262 }, "evidence": [ { "id": "E1BD88", "url": "https://omabrowser.org/oma/group/E1BD88/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q4V8J7-1", "protein_name": "Spindlin-1", "gene_name": "Spin1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKTPFGKTPGQRSRADAGHAGVSANMMKKRTSHKKHRTSVGPSKPVSQPRRNIVGCRIQHGWREGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDDRVSALEVLPDRVATSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPVMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQVEYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS", "length": 262 }, "evidence": [ { "id": "E1BD88", "url": "https://omabrowser.org/oma/group/E1BD88/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q61142-1", "protein_name": "Spindlin-1", "gene_name": "Spin1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTPFGKTPGQRSRADAGHAGVSANMMKKRTSHKKHRTSVGPSKPVSQPRRNIVGCRIQHGWREGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEVLPDRVATSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPVMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQVEYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS", "length": 262 }, "evidence": [ { "id": "E1BD88", "url": "https://omabrowser.org/oma/group/E1BD88/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q90WG2-1", "protein_name": "Spindlin-W", "gene_name": "SPINW", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": 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"glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BD88", "url": "https://www.uniprot.org/uniprotkb/E1BD88" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "E1BD88", "url": "https://www.uniprot.org/uniprotkb/E1BD88" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BD88", "url": "https://www.uniprot.org/uniprotkb/E1BD88" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": 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"phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDF9-1", "uniprot_ac": "E1BDF9", "uniprot_id": "E1BDF9_BOVIN", "mass": { "chemical_mass": 120758.0, "monoisotopic_mass": 120758.0 }, "refseq": { "ac": "XP_010819940", "name": "protocadherin-19 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819940" }, "gene_names": [ { "name": "PCDH19", "type": "recommended", "evidence": [ { "id": "E1BDF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDF9" } ] }, { "name": "PCDH19", "type": "synonym", "evidence": [ { "id": "XP_010819940", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819940" } ] } ], "protein_names": [ { "name": "Protocadherin-19", "type": "recommended", "evidence": [ { "id": "E1BDF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDF9/entry#names_and_taxonomy" } ] }, { "name": "protocadherin-19 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_010819940", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819940" } ] } ], "function": [ { "annotation": "Calcium-dependent cell-adhesion protein.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LJ38", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJ38#function" }, { "database": "UniProtKB", "id": "ARBA00055507", "url": "https://www.uniprot.org/uniprotkb/ARBA00055507#function" }, { "database": "UniProtKB", "id": "E1BDF9", "url": "https://www.uniprot.org/uniprotkb/E1BDF9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDF9", "url": "https://www.uniprot.org/uniprotkb/E1BDF9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCDH19", "url": "https://www.uniprot.org/uniprotkb/E1BDF9", "locus": { "chromosome": "X", "start_pos": 49302934, "end_pos": 49431015, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014169", "url": "https://www.ensembl.org/id/ENSBTAG00000014169" } ] } } ], "crossref": [ { "id": "E1BDF9", "url": "https://alphafold.ebi.ac.uk/entry/E1BDF9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014169", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014169", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "524109", "url": "https://www.ncbi.nlm.nih.gov/gene/524109", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050174", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050174", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524109", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524109", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RCWMPRG", "url": "https://omabrowser.org/oma/group/RCWMPRG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LJ38", "url": "https://www.orthodb.org/?gene=A0A3Q1LJ38", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BDF9", "url": "https://www.orthodb.org/?gene=E1BDF9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028:SF40", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028:SF40", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08266", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08266", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010819940", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819940", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJ38", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJ38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJ38-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJ38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDF9", "url": "https://www.uniprot.org/uniprotkb/E1BDF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDF9-1", "url": "https://www.uniprot.org/uniprotkb/E1BDF9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESLLLPVLLLLAVLWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPHLGTVGLSIKVTDSNDNNPVFGESTYSVSVPENSPPNTPVIRLNATDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVRITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKADDYDEGENGRVTYDMTEGDRGFFEIDQINGEVRTTRTFSESSKASYELIVVAHDHGKTSLSASALVLIYLSPALDAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCRIAEYSYGHQKKSSKKKKISKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRRSESTFLNVENQNTRNTSANHIYHHSFNSQGPQQPDLIINGMPLPETENYSFDSNYVNSRAHLIKSSSTFKDLEGNSLKDSGHEESDQTDSEHDIQRSLYCDTAVNDVLNTSVTSMGSQMPDHDQNEGFHCREECRILGHSDRCWMPRNPMPTCSKSPEHVRNIITLSIEATAADVEAYDDCGPTKRTFATFGKDVSDHPAEERPTLKGRRTVDVTTCSPKVNSAIREAGNGCEAISPVTSPLHLKSPLPTKPSVSYTVALAPPARDLEQYVNNGPSRPSEAEPRGADGEKVVHEVNPILKEGRDKESPGVKRLKDIIL", "length": 1098, "header": "tr|E1BDF9-1|E1BDF9_BOVIN Isoform 1 of Protocadherin-19 OS=Bos taurus OX=9913 GN=PCDH19 PE=4 SV=2 CANONICAL=E1BDF9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJ38-1", "url": "https://www.uniprot.org/uniprotkb/E1BDF9/entry#A0A3Q1LJ38-1", "sequence": { "sequence": "MESLLLPVLLLLAVLWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPHLGTVGLSIKVTDSNDNNPVFGESTYSVSVPENSPPNTPVIRLNATDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVRITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKADDYDEGENGRVTYDMTEGDRGFFEIDQINGEVRTTRTFSESSKASYELIVVAHDHGKTSLSASALVLIYLSPALDAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCSNCLTITCLLGCFIKGQNSKCLHCISVSPISEEQDKKAEEKVSLRGKRIAEYSYGHQKKSSKKKKISKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRRSESTFLNVENQNTRNTSANHIYHHSFNSQGPQQPDLIINGMPLPETENYSFDSNYVNSRAHLIKSSSTFKDLEGNSLKDSGHEESDQTDSEHDIQRSLYCDTAVNDVLNTSVTSMGSQMPDHDQNEGFHCREECRILGHSDRCWMPRNPMPTCSKSPEHVRNIITLSIEATAADVEAYDDCGPTKRTFATFGKDVSDHPAEERPTLKGRRTVDVTTCSPKVNSAIREAGNGCEAISPVTSPLHLKSPLPTKPSVSYTVALAPPARDLEQYVNNGPSRPSEAEPRGADGEKVVHEVNPILKEGRDKESPGVKRLKDIIL", "length": 1145, "header": "tr|A0A3Q1LJ38-1|E1BDF9_BOVIN Computationally mapped isoform of Protocadherin-19 OS=Bos taurus OX=9913 GN=PCDH19 PE=4 SV=1 CANONICAL=E1BDF9-1" }, "locus": { "chromosome": "X", "start_pos": 49430816, "end_pos": 49303938, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079574.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079574.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059291.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059291.1" } ] } }, { "isoform_ac": "E1BDF9-1", "url": "https://www.uniprot.org/uniprotkb/E1BDF9/entry#E1BDF9-1", "sequence": { "sequence": "MESLLLPVLLLLAVLWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPHLGTVGLSIKVTDSNDNNPVFGESTYSVSVPENSPPNTPVIRLNATDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVRITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKADDYDEGENGRVTYDMTEGDRGFFEIDQINGEVRTTRTFSESSKASYELIVVAHDHGKTSLSASALVLIYLSPALDAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCRIAEYSYGHQKKSSKKKKISKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRRSESTFLNVENQNTRNTSANHIYHHSFNSQGPQQPDLIINGMPLPETENYSFDSNYVNSRAHLIKSSSTFKDLEGNSLKDSGHEESDQTDSEHDIQRSLYCDTAVNDVLNTSVTSMGSQMPDHDQNEGFHCREECRILGHSDRCWMPRNPMPTCSKSPEHVRNIITLSIEATAADVEAYDDCGPTKRTFATFGKDVSDHPAEERPTLKGRRTVDVTTCSPKVNSAIREAGNGCEAISPVTSPLHLKSPLPTKPSVSYTVALAPPARDLEQYVNNGPSRPSEAEPRGADGEKVVHEVNPILKEGRDKESPGVKRLKDIIL", "length": 1098, "header": "tr|E1BDF9-1|E1BDF9_BOVIN Isoform 1 of Protocadherin-19 OS=Bos taurus OX=9913 GN=PCDH19 PE=4 SV=2 CANONICAL=E1BDF9-1" }, "locus": { "chromosome": "X", "start_pos": 49430816, "end_pos": 49303938, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030214.6", "url": "https://www.ensembl.org/id/ENSBTAT00000030214.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030199.4", "url": "https://www.ensembl.org/id/ENSBTAP00000030199.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 932, "start_aa": "Thr", "end_pos": 932, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr932", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:524109", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524109", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A135-1", "protein_name": "Protocadherin-19", "gene_name": "PCDH19", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MESLLLPVLLLLAVLWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPHLGTVGLSIKVTDSNDNNPVFGESTYSVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVRITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKADDYDEGENGRVTYDMTEGDRGFFEIDQVNGEVRTTRTFSESSKASYELIVVAHDHGKTSLSASALVLIYLSPALDAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCRIAEYSYGHQKKSSKKKKISKNDIRLVPREVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRRSESTFLNVENQNTRNASANHIYHHSFNSQGPQQPDLIINGVPLPETENYSFDSNYVNSRAHLIKSSSTFKDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQMPDHDQNEGFHCREECRILGHSDRCWMPRNPMPTRSKSPEHVRNIIALSIEATAADVEAYDDCGPTKRTFATFGKDVSDHPAEERPSVKGRRTVDVTICSPKVNSAIREAGNGCEAISPVTSPLHLKSPLPTKPSVSYTVALAPPARDLEQYVNNGPSRPSEAEPRGADGEKVMHEVNPILKEGRDKDSPGVKRLKDIVL", "length": 1098 }, "evidence": [ { "id": "E1BDF9", "url": "https://omabrowser.org/oma/group/E1BDF9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YZW6-1", "protein_name": "Protocadherin-19", "gene_name": "PCDH19", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGALPALLGAALLWAGAGALVNLKYSVEEEQRAGTVIANIAKDARDAGFVIDPRQPTAFRVVSNSAPHLVDINPGSGLLVTKQKIDRDLLCRQSPKCVISLEVMSSSMEICVIKLEIKDLNDNAPSFPTDQIELEISETASPGTRVPLESAYDPDSGSFGVQSYQITPNDLFGLETKTRGDGSRFAELVVEKSLDRETQSHYSYVITALDGGDPPNFGTVELSIRVIDSNDNNPLFEEPAYTVSVPENAPPGTPVIRLNASDPDEGTNGQVLYSFHSYVSDRARELFQIDPQSGLITVSGAIDYEEGHVYELDVQAKDLGPNSIPAHCKVTISVQDANDNPPLINLLSVNSELVEVSENAPPGYVIALVRVSDRDSGANGRVQCKLLGNVPFRLQEYESFSTILVDGRLDREQRDQYNLTIQAKDNGVPSLQATKSFTVKITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGNPSLQSNATVRVIVLDVNDNTPVITAPPLVNGTAEVYIPRNAGVGYLVTVVKADDYDEGENGRLSYEMVEGDRGFFEIDQVNGEIRTTRAFGENAKTAYELIVVAHDHGKTSLSASALILIYLSPALDAQESIGSVNLSLIFIIALGSIAAILFVTMIFVAVKCKRDNKEIRTYNCRIAEYSYGHQKKSSKKKKISKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRRSDSTFLNVESQNSRNAGSNHIYHHTFTGQSPQQPDLIINGMPLPETENYSFDSNYVNSRAHLIKSSSTFKDLEGNSLKDSGHEESDQTDSEHDVQRGLYCDTAVNDVLNTSVPSMGSQGPEPDQSEGFHCREECRILGHSDRCWMPRSAVPSRTKSPEHSRNVIALSIEATAVDAEPYADCSAKRTFATFGKEGGEPPAEERPGNPKGKRTVEPAAGSPKVSGAVREAGNGCEAASPVTSPLHLKGPAAYSGLPCPTGRPPANTGPARPAEAEPRGADSEGGLQEGNPLLQDRREKDSPAGRRLRDIVL", "length": 1087 }, "evidence": [ { "id": "E1BDF9", "url": "https://omabrowser.org/oma/group/E1BDF9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZG18-1", "protein_name": "Protocadherin-19", "gene_name": "Pcdh19", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MESLLLPVLLLLAVLWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFAMDTRQASAFRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPHMGTVGLTIKVTDSNDNNPVFGESTYSVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPIINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYNLTIQARDSGVPMLQSAKSFTVRITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGMPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKADDYDEGENGRVTYDMTEGDRGFFEIDQVNGEVRTTRTFNENSKASYELIVVAHDHGKTSLSASALVLIYLSPALDAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCRIAEYSYGHQKKSSKKKKISKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRRSESTFLNVENQNTRNTTANHIYHHSFNSQGPQQPDLIINGVPLPETENYSFDSNYVNSRAHLIKSSSTFKDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSHMPDHDQNDGFHCREECRILGHSDRCWMPRNPMPTRSKSPEHMRNIIALSIEATAADVEAYDDCGPTKRTFATFGKDVSSHPAEERSILKGKRTVDVTICSPKVNSAIREAGNGCEAISPVTSPLHLKSPLPTKPSMSYTVALAPPAHDLDHHANTGASRPSEAEPRGADSEKVMHEVNPILKEGRDKESPAVKRLKDIIL", "length": 1098 }, "evidence": [ { "id": "E1BDF9", "url": "https://omabrowser.org/oma/group/E1BDF9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80TF3-1", "protein_name": "Protocadherin-19", "gene_name": "Pcdh19", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESLLLPVLLLLAVLWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPHMGTVGLSIKVTDSNDNNPVFGESTYSVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPIINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYNLTIQARDSGVPMLQSAKSFTVRITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDMGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKADDYDEGENGRVTYDMTEGDRGFFEIDQVNGEVRTTRTFNENSKPSYELIVVAHDHGKTSLSASALVLIYLSPALDAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCSNCLTITCLLGCFIKGQNSKCLHCISVSPNSEEQDKKAEEKVSLRGKRIAEYSYGHQKKSSKKKKISKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRRSESTFLNVENQNTRNTTASHIYHHSFNSQGPQQPDLIINGVPLPETENYSFDSNYVNSRAHLIKSSSTFKDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQMPDHDQNEGFHCREECRILGHSDRCWMPRNPMPTRSKSPEHVRNIIALSIEATAADVEAYDDCGPTKRTFATFGKDVSSHRAEERPILKGKRTVDVTICSPKVNSAIREAGNGCEAISPVTSPLHLKSPLPTKPSISYTVALAPPAHDLEHHANSGASRPSEAEPRGADNEKVMHEVNPIRKDGRDKESPSVKRLKDIVL", "length": 1145 }, "evidence": [ { "id": "E1BDF9", "url": "https://omabrowser.org/oma/group/E1BDF9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TAB3-1", "protein_name": "Protocadherin-19", "gene_name": "PCDH19", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESLLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLIYLSPALDAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCSNCLTITCLLGCFIKGQNSKCLHCISVSPISEEQDKKTEEKVSLRGKRIAEYSYGHQKKSSKKKKISKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRRSESTFLNVENQNTRNTSANHIYHHSFNSQGPQQPDLIINGVPLPETENYSFDSNYVNSRAHLIKSSSTFKDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQMPDHDQNEGFHCREECRILGHSDRCWMPRNPMPIRSKSPEHVRNIIALSIEATAADVEAYDDCGPTKRTFATFGKDVSDHPAEERPTLKGKRTVDVTICSPKVNSVIREAGNGCEAISPVTSPLHLKSSLPTKPSVSYTIALAPPARDLEQYVNNVNNGPTRPSEAEPRGADSEKVMHEVSPILKEGRNKESPGVKRLKDIVL", "length": 1148 }, "evidence": [ { "id": "E1BDF9", "url": "https://omabrowser.org/oma/group/E1BDF9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BDF9", "url": "https://www.uniprot.org/uniprotkb/E1BDF9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "E1BDF9", "url": "https://www.uniprot.org/uniprotkb/E1BDF9" } ], "pmid": "" }, { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "E1BDF9", "url": "https://www.uniprot.org/uniprotkb/E1BDF9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "E1BDF9", "url": "https://www.uniprot.org/uniprotkb/E1BDF9" } ], "pmid": "" }, { "name": "cell adhesion molecule binding", "id": "GO:0050839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050839", "evidence": [ { "database": "UniProtKB", "id": "E1BDF9", "url": "https://www.uniprot.org/uniprotkb/E1BDF9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" }, { "start_pos": 420, "end_pos": 422, "annotation": "n_glycosylation_sequon" }, { "start_pos": 465, "end_pos": 467, "annotation": "n_glycosylation_sequon" }, { "start_pos": 485, "end_pos": 487, "annotation": "n_glycosylation_sequon" }, { "start_pos": 546, "end_pos": 548, "annotation": "n_glycosylation_sequon" }, { "start_pos": 570, "end_pos": 572, "annotation": "n_glycosylation_sequon" }, { "start_pos": 676, "end_pos": 678, "annotation": "n_glycosylation_sequon" }, { "start_pos": 795, "end_pos": 797, "annotation": "n_glycosylation_sequon" }, { "start_pos": 828, "end_pos": 830, "annotation": "n_glycosylation_sequon" }, { "start_pos": 889, "end_pos": 891, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDF9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1098, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDF9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDF9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDF9" }, { "id": "PS50268", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50268" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cadherin", "eco_id": "ECO_0000259", "start_pos": 28, "end_pos": 129, "start_aa": "Ser", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 932 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 261, "end_pos": 263 }, { "start_pos": 420, "end_pos": 422 }, { "start_pos": 465, "end_pos": 467 }, { "start_pos": 485, "end_pos": 487 }, { "start_pos": 546, "end_pos": 548 }, { "start_pos": 570, "end_pos": 572 }, { "start_pos": 676, "end_pos": 678 }, { "start_pos": 795, "end_pos": 797 }, { "start_pos": 828, "end_pos": 830 }, { "start_pos": 889, "end_pos": 891 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDD9-1", "uniprot_ac": "E1BDD9", "uniprot_id": "E1BDD9_BOVIN", "mass": { "chemical_mass": 118316.0, "monoisotopic_mass": 118316.0 }, "refseq": { "ac": "XP_005207502", "name": "myocardin-related transcription factor A isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207502" }, "gene_names": [ { "name": "MRTFA", "type": "recommended", "evidence": [ { "id": "E1BDD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDD9" } ] }, { "name": "MRTFA", "type": "synonym", "evidence": [ { "id": "XP_005207502", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207502" } ] } ], "protein_names": [ { "name": "Myocardin related transcription factor A", "type": "synonym", "evidence": [ { "id": "E1BDD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDD9/entry#names_and_taxonomy" } ] }, { "name": "myocardin-related transcription factor A isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005207502", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207502" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDD9", "url": "https://www.uniprot.org/uniprotkb/E1BDD9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRTFA", "url": "https://www.uniprot.org/uniprotkb/E1BDD9", "locus": { "chromosome": "5", "start_pos": 111739794, "end_pos": 111951172, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002630", "url": "https://www.ensembl.org/id/ENSBTAG00000002630" } ] } } ], "crossref": [ { "id": "E1BDD9", "url": "https://alphafold.ebi.ac.uk/entry/E1BDD9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002630", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002630", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "509011", "url": "https://www.ncbi.nlm.nih.gov/gene/509011", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004018", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004018", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043451", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043451", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509011", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509011", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NQSVRKP", "url": "https://omabrowser.org/oma/group/NQSVRKP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LLJ2", "url": "https://www.orthodb.org/?gene=A0A3Q1LLJ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22793", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22793", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22793:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22793:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02037", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02037", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02755", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02755", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3899300", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3899300", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005207502", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207502", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLJ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRT6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRT6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRT6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRT6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDD9", "url": "https://www.uniprot.org/uniprotkb/E1BDD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDD9-1", "url": "https://www.uniprot.org/uniprotkb/E1BDD9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSLKSEGRRMSLLQHWPLESHLSPSMLEERARIYQPTCRILPLPWIVLKPGKDSRSAMCLAPYHSLREVLQLKLQQRRTREELVSQGIMPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEAIIVGQVNYPKVADSSSFDEDSSDALSPEQPASHESQGSVPSPLEARVSEPPPSATSVSPTQVVSQLPVGPESGETLFLAEQPPLPPSLTNGTTVPAAKPLPTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYIPPDQKQDKGAPPMDSSYAKILQQQQLFLQLQILNQQQQQQQQQHYNYQTILPAPPKPAGEALGSAGGAPTRSLSATGSSSGSGAPGPSGLVRQNSTSLAGKPGALPANLDDMKVAELKQELKLRSLPVSGTKTDLIERLRAYQEQVTPASPGAPKAPATSLLPKAGEVVVAFPTARLSTGPALVAAGLAPAEVVVATVTSNGVVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDSFGEMVTSPVTQLTLQASPLQVLVKEEGPRPGACCRSPGARAELEGRDKDQMLQEKDKQIEELTRMLRQKQQLVEWLRLQLEQEKRAQQPTPTPAPAPLALGPAVKQESNLASCQLSRRPPGPELPFSPSLAAPAAPHADARALVSPAVVVKQEAVGSEPEPAPALVTLGPTVKQENSFTSCQLSRQPLGPELPFGPSLAAPAAPHAEACALAPPVVVVKQEAVPPEPEAAPAPQLLLGPQGPSLVKGVTPPPLLTDSAGTHLVLTVTKNTDSPGLASGSPQQRGQSSPSKVTLASGSLLPPPSQPRPSTQPGPKPLSQPESPAPGPPGHMDLEPPPQPLFGTPASQPKKEPPGYEEAVSQQPRRQENGSSSQQMDDLFDILIQSGEISADFKEPGKEKAPPTAACSSPLAAQPSPAAELPQAAPPPSGSPALPGRLEDFLESSTGLPLLTGGHEGPEPLSLIDDLHSQMLSSSAILDHPPSPMDTSELHFAPEPSGVGLDLADGHLDSMDWLELSSGGPVLSLAPLSTTAPSLFSTDFLDGHDLQLHWDSCL", "length": 1114, "header": "tr|E1BDD9-1|E1BDD9_BOVIN Isoform 1 of Myocardin related transcription factor A OS=Bos taurus OX=9913 GN=MRTFA PE=4 SV=4 CANONICAL=E1BDD9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LLJ2-1", "url": "https://www.uniprot.org/uniprotkb/E1BDD9/entry#A0A3Q1LLJ2-1", "sequence": { "sequence": "MTLLEPEMLMMAVQSVLQLKLQQRRTREELVSQGIMPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEAIIVGQVNYPKVADSSSFDEDSSDALSPEQPASHESQGSVPSPLEARVSEPPPSATSVSPTQVVSQLPVGPESGETLFLAEQPPLPPSLTNGTTVPAAKPLPTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYIPPDQKQDKGAPPMDSSYAKILQQQQLFLQLQILNQQQQQQQQQHYNYQTILPAPPKPAGEALGSAGGAPTRSLSATGSSSGSGAPGPSGLVRQNSTSLAGKPGALPANLDDMKVAELKQELKLRSLPVSGTKTDLIERLRAYQEQVTPASPGAPKAPATSLLPKAGEVVVAFPTARLSTGPALVAAGLAPAEVVVATVTSNGVVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDSFGEMVTSPVTQLTLQASPLQVLVKEEGPRPGACCRSPGARAELEGRDKDQMLQEKDKQIEELTRMLRQKQQLVEWLRLQLEQEKRAQQPTPTPAPAPLALGPAVKQESNLASCQLSRRPPGPELPFSPSLAAPAAPHADARALVSPAVVVKQEAVGSEPEPAPALVTLGPTVKQENSFTSCQLSRQPLGPELPFGPSLAAPAAPHAEACALAPPVVVVKQEAVPPEPEAAPAPQLLLGPQGPSLVKGVTPPPLLTDSAGTHLVLTVTKNTDSPGLASGSPQQRGQSSPSKVTLASGSLLPPPSQPRPSTQPGPKPLSQPESPAPGPPGHMDLEPPPQPLFGTPASQPKKEPPGYEEAVSQQPRRQENGSSSQQMDDLFDILIQSGEISADFKEPGKEKAPPTAACSSPLAAQPSPAAELPQAAPPPSGSPALPGRLEDFLESSTGLPLLTGGHEGPEPLSLIDDLHSQMLSSSAILDHPPSPMDTSELHFAPEPSGVGLDLADGHLDSMDWLELSSGGPVLSLAPLSTTAPSLFSTDFLDGHDLQLHWDSCL", "length": 1060, "header": "tr|A0A3Q1LLJ2-1|E1BDD9_BOVIN Computationally mapped isoform of Myocardin related transcription factor A OS=Bos taurus OX=9913 GN=MRTFA PE=4 SV=1 CANONICAL=E1BDD9-1" }, "locus": { "chromosome": "5", "start_pos": 111851013, "end_pos": 111740798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070929.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070929.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060646.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060646.1" } ] } }, { "isoform_ac": "A0AAA9SRT6-1", "url": "https://www.uniprot.org/uniprotkb/E1BDD9/entry#A0AAA9SRT6-1", "sequence": { "sequence": "VDFSSVVCLPPSVIAVNGLDGGGAGENDDEPVLVSLSAAPSPQSEAVANELQELSLQPELTLGLHPGRNPNLPPLSERKNVLQLKLQQRRTREELVSQGIMPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEAIIVGQVNYPKVADSSSFDEDSSDALSPEQPASHESQGSVPSPLEARVSEPPPSATSVSPTQVVSQLPVGPESGETLFLAEQPPLPPSLTNGTTVPAAKPLPTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYIPPDQKQDKGAPPMDSSYAKILQQQQLFLQLQILNQQQQQQQQQHYNYQTILPAPPKPAGEALGSAGGAPTRSLSATGSSSGSGAPGPSGLVRQNSTSLAGKPGALPANLDDMKVAELKQELKLRSLPVSGTKTDLIERLRAYQEQVTPASPGAPKAPATSLLPKAGEVVVAFPTARLSTGPALVAAGLAPAEVVVATVTSNGVVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDSFGEMVTSPVTQLTLQASPLQVLVKEEGPRPGACCRSPGARAELEGRDKDQMLQEKDKQIEELTRMLRQKQQLVEWLRLQLEQEKRAQQPTPTPAPLGPTVKQENSFTSCQLSRQPLGPELPFGPSLAAPAAPHAEACALAPPVVVVKQEAVPPEPEAAPAPQLLLGPQGPSLVKGVTPPPLLTDSAGTHLVLTVTKNTDSPGLASGSPQQPLSQPESPAPGPPGHMDLEPPPQPLFGTPASQPKKEPPGYEEAVSQQPRRQENGSSSQQMDDLFDILIQSGGKLRDLSGFQGAREREGAPDSSLQLAPGRPALARGR", "length": 890, "header": "tr|A0AAA9SRT6-1|E1BDD9_BOVIN Computationally mapped isoform of Myocardin related transcription factor A OS=Bos taurus OX=9913 GN=MRTFA PE=4 SV=1 CANONICAL=E1BDD9-1" }, "locus": { "chromosome": "5", "start_pos": 111873390, "end_pos": 111741201, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131991.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131991.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088086.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088086.1" } ] } }, { "isoform_ac": "E1BDD9-1", "url": "https://www.uniprot.org/uniprotkb/E1BDD9/entry#E1BDD9-1", "sequence": { "sequence": "MDSLKSEGRRMSLLQHWPLESHLSPSMLEERARIYQPTCRILPLPWIVLKPGKDSRSAMCLAPYHSLREVLQLKLQQRRTREELVSQGIMPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEAIIVGQVNYPKVADSSSFDEDSSDALSPEQPASHESQGSVPSPLEARVSEPPPSATSVSPTQVVSQLPVGPESGETLFLAEQPPLPPSLTNGTTVPAAKPLPTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYIPPDQKQDKGAPPMDSSYAKILQQQQLFLQLQILNQQQQQQQQQHYNYQTILPAPPKPAGEALGSAGGAPTRSLSATGSSSGSGAPGPSGLVRQNSTSLAGKPGALPANLDDMKVAELKQELKLRSLPVSGTKTDLIERLRAYQEQVTPASPGAPKAPATSLLPKAGEVVVAFPTARLSTGPALVAAGLAPAEVVVATVTSNGVVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDSFGEMVTSPVTQLTLQASPLQVLVKEEGPRPGACCRSPGARAELEGRDKDQMLQEKDKQIEELTRMLRQKQQLVEWLRLQLEQEKRAQQPTPTPAPAPLALGPAVKQESNLASCQLSRRPPGPELPFSPSLAAPAAPHADARALVSPAVVVKQEAVGSEPEPAPALVTLGPTVKQENSFTSCQLSRQPLGPELPFGPSLAAPAAPHAEACALAPPVVVVKQEAVPPEPEAAPAPQLLLGPQGPSLVKGVTPPPLLTDSAGTHLVLTVTKNTDSPGLASGSPQQRGQSSPSKVTLASGSLLPPPSQPRPSTQPGPKPLSQPESPAPGPPGHMDLEPPPQPLFGTPASQPKKEPPGYEEAVSQQPRRQENGSSSQQMDDLFDILIQSGEISADFKEPGKEKAPPTAACSSPLAAQPSPAAELPQAAPPPSGSPALPGRLEDFLESSTGLPLLTGGHEGPEPLSLIDDLHSQMLSSSAILDHPPSPMDTSELHFAPEPSGVGLDLADGHLDSMDWLELSSGGPVLSLAPLSTTAPSLFSTDFLDGHDLQLHWDSCL", "length": 1114, "header": "tr|E1BDD9-1|E1BDD9_BOVIN Isoform 1 of Myocardin related transcription factor A OS=Bos taurus OX=9913 GN=MRTFA PE=4 SV=4 CANONICAL=E1BDD9-1" }, "locus": { "chromosome": "5", "start_pos": 111803036, "end_pos": 111740798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003407.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003407.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003407.7", "url": "https://www.ensembl.org/id/ENSBTAP00000003407.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 543, "start_aa": "Thr", "end_pos": 543, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr543", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 654, "start_aa": "Thr", "end_pos": 654, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr654", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:509011", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509011", "resource": "KEGG Pathway" }, { "id": "R-BTA-3899300", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3899300", "resource": "Reactome", "description": "SUMOylation of transcription cofactors" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5Y2C3-1", "protein_name": "Myocardin related transcription factor A", "gene_name": "Mrtfa", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "VDFSSVVCLPPSVIAVNGLDGGGAGENDEEPVLLSLSAAPSPQSEAVANELQELSLQPELTLGLHPGRNPNLPPLSERKNVLQLKLQQRRTREELVSQGIMPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEALIVGQVNYPKVADSSSFDEDSSDALSPEQPASHESQGSVPSPLESRASDLLPSATSISPTQQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYIPPDQKQDKGAPAMDSSYAKILQQQQLFLQLQILNQQQQQQQQQHYNYQAILPAPPKPSGETPGSSAPTPSRSLSTSSSSSSGTPGPGGLARQNSTALAGKPGALPANLDDMKVAELKQELKLRSLPVSGTKTELIERLRAYQDQVSPAPGAPKAPATTSVLSKAGEVVVAFPAALLSTGSALVTAGLAPAEMVVATVTSNGMVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDAFGEMVTSPLTQLTLQASPLQIVKEEGARAASCCLSPGARAELEGLDKDQMLQEKDKQIEELTRMLQQKQQLVELLRLQLEQQKRAQQPAPASSPVKRESSFSSCQLSCQPQGAARAFGPGLVVPTTNHGDAQAPAPESPPVVVKQEAGPPEPDLAPASQLLLGSQGTSFLKKVSPPTLVTDSTGTHLILTVTNKSADGPGLPTGSPQQPLSQPGSPAPGPPAQMDLEHPPQPSFATPTSLLKKEPPGYEETVTQQPKQQENGSSSQHMDDLFDILIQSGEISADFKEPPSLPGKEKSPPAEAYGPPLTPQPSPLSELPQAAPPPGSPTLPGRLEDFLESSTGLPLLTSGHEGPEPLSLIDDLHSQMLSSSAILDHPPSPMDTSELHFAPEPSSGMGLDLAVGHLDSMDWLELSSGGPVLSLAPLSTTAPSLFSMDFLDGHDLQLHWDSCL", "length": 978 }, "evidence": [ { "id": "E1BDD9", "url": "https://omabrowser.org/oma/group/E1BDD9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8M9QIR6-1", "protein_name": "Myocardin related transcription factor Ab isoform X1", "gene_name": "mrtfab", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLDTNHCLHIDASSFEDQLIQNAEDKMPVSLDCDRHAYHNLKEVLQLKLQQRRTREELVSQGIMPPLKSPAAFHEQRKSLERARTEDYLKRKIRSRPERSELVRMHILEVTTETASSSVCKTNIKTSAEPSLQAKQLKLKRARLADDLNDKISHRPGPIELIHKNILPVHALIGTESPKGESSSLDEDSSDALSPDPQCSQDSPLGLGPQHSPSDMLNMNGDLSPSQFLTQAPPPLLVTSDASPPKNLTSETNISNSSRPPSGHTKSKSSTDRTYQRSKKPKDNKPKVKKLKYHQYIPPDQKNDREPPPQLDSSYAKILHQQQLFLQLQIINQQQQHYNYHTILPAPPKLATEMQQPSTNPGPAPSQTISTSTAVSSNQTGTSRQSQPTVAGAKPSTLPANLDEFKVAELKHELKLRGLTVSGTKNDLIERLKNYQEQNCGSSAAGAPAMKTVPAQLPQVSIQSGPHQHPKDTTVPISAFPLTPTTRVHSTTPPQIMRFSSTSSSPPVSPTPSDRSVTGLSPDEASCNGDVFGEMVSSPLTQLSLHPSPEQPSPIKEESLGQVQSSCSLSRLGTLPAAQPHDPCPLSPLDKDQMLQEKDKQIEELTRMLRQKQRQVEALRSQLEQGKRAAPTEPAVDTEIPMLSNGVEVKVKEEVKEEMDTSEDLQKQIQPLKKIQTQCSQQTLFKLQQIHRLQVQQQQILVDLPNLQNTQQQEVDQLKVQQEQAKTQVSQQQKTQLLQHHQKVQLLQQQKAQLLQQQQKAQLLQQQQQKAQLLQQQQRTLVQEQQKTQLHQQKKTTLLQQQQQQKLQQLIIQQSQQKQLQANLKQQQKPQNLLQSPQVSQMFVSQQSSTQITTSFPLDILKAHPTPTLVTDSNGNRYLIALTSNSVESLTGKSPQSKSNGRITLQRLQSTPIKLPSQSSTDMTTSANHSQAVREPITKKAGLHVETSSVQESSQPVSAPPSFEPFFCEESNPLNKPTSPPSFKEDICPTFDRHTLFTPSSPKPNPQPPQCLKDNVSNNQQIDDLFEILMKSGEISSGFKASQDPSLSDLHSNPPSPSPPPSPLHLSPPAHHPEPMPVPSQQLLDTQNRPCSSTGRLEDFLESTTGAPLLGVEPDSPLTLIDDLHSQMLSTSSILDHPPSPMDTSDLSFSSHPASLDFEDPALDGMDWLGIPVVTGGSNCNGGGLVLAPLSSHTPPSVFSADFLDSPDLQLHWDSCL", "length": 1217 }, "evidence": [ { "id": "E1BDD9", "url": "https://omabrowser.org/oma/group/E1BDD9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0YKB1-1", "protein_name": "Myocardin related transcription factor A", "gene_name": "MKL1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNTGCPRGLRTGGRSLASSCVSRSLEALENKEGDWRESCWHGSELGLFVGTLSKVAITKAKVDFSGVVCLPPSVIAGNGLDGGGAGENDDEPVLVSLSAAPSPQSEAVANELQELSLQPELTLSLHHGRNPNLPPLSERKNVLQLKLQQRRTREELVSQGIMPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEAIIVGQVNYPKVADNSSFDEDSSDALSPEQPASHESQGSVPSPMDSRICDPLPSTTGTSLAQGTSQLQISADSNETLFLPEQPPPPLPPPPLLPPSLTNGAALPAAKPPPTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYIPPDQKQDKGAPPMDSSYAKILQQQQLFLQLQILNQQQQQHYNYQTILPAPPKPPGEQQTGASAPAVRNLSAAVNSTSSVSSGSSGLMRQNSNAAVGKPGPLPANLDEMKVAELKQELKLRALPVSGTKTDLIERLRAYQEQNGTAGQTTPTPKPSTAAILPKAAEVVVAFPAARLSTGPALVTTGIAPAEVVVATVTGGGVMKFGSTGSTPPVSPTPSERSQMSTGDENSATGDTFGEMVTSPLTQLTLQASPVQFLVKEESSKSASCSISAAPRSERCSTGNSRDAEVRDKDQMLQEKDKQIEELTRMLKQKQQLVEMLRLQLEQEKRAQQSLPAPAAAGEGTALASNPVAFGIQVKSENGFLSCQSAKQSSGQTDQFNPAPTSSQMDTSNPSPVPKKAVMVKQEVPATEAEPPCQSHSPQLFLGQQGSALSDLIKGTPPPTLITDSTGTHIVLTVTKQSAERQGLSPQGKAVSSCPTSQRVQSLPTKTSSQPQCQPPASTPQQPTPQQQQQQQQQPRGLNQPVRKPSSQPSSPAAPSPSQMDLEQQQQQQKQQHTSLFGPPPPPLPVPSVPLKEPPGYEEAMKQQPKTQENGCSSQQMDDLFDILIESGEISADFKDQSSPAGKEPPAAPACSSPPSSHHSSELAVPVSLGQTVPVGRLEDFLESSTGLPLLTAGHDGPEPLSLIDDLHSEMLSSSAILDHPPSPMDTSELHFAHEPAGGIALDLAEANLDSMDWLELPGGSVMSLAPLSTTAPSLFSTDFLDGHDLQLHWDSCL", "length": 1182 }, "evidence": [ { "id": "E1BDD9", "url": "https://omabrowser.org/oma/group/E1BDD9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8K4J6-1", "protein_name": "Myocardin-related transcription factor A", "gene_name": "Mrtfa", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTLLEPEMLMMAVQSVLQLKLQQRRTREELVSQGIMPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERAELVRMHILEETSAEPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEAIIVGQVNYPKVADSSSFDEDSSDALSPEQPASHESQGSVPSPLESRVSDPLPSATSISPTQVLSQLPMAPDPGETLFLAEQPPLPPAPLLPPSLANGSIVPTAKPAPTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYIPPDQKQDKGAPAMDSSYAKILQQQQLFLQLQILNQQQQQQQQQHYNYQAILPAPPKPSAETPGSSAPTPSRSLSTSSSPSSGTPGPSGLARQSSTALAAKPGALPANLDDMKVAELKQELKLRSLPVSGTKTELIERLRAYQDQVSPAPGAPKAPATTSVLSKAGEVVVAFPAALLSTGSALVTAGLAPAEMVVATVTSNGMVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDAFGEMVTSPLTQLTLQASPLQIVKEEGARAASCCLSPGARAELEGLDKDQMLQEKDKQIEELTRMLQQKQQLVELLRLQLEQQKRAQQPAPASSPVKRESGFSSCQLSCQPQGSAHAFGSGLVVPTTNHGDTQAPAPESPPVVVKQEAGPPEPDLAPSSQLLLGSQGTSFLKRVSPPTLVTDSTGTHLILTVTNKSADGPGLPAGSPQQPLSQPGSPAPGPPAQMDLEHPPQPPFATPTSLLKKEPPGYEETVTQQPKQQENGSSSQHMDDLFDILIQSGEISADFKEPPSLPGKEKSPPAAAAYGPPLTPQPSPLSELPQAAPPPGSPTLPGRLEDFLESSTGLPLLTSGHEGPEPLSLIDDLHSQMLSSSAILDHPPSPMDTSELHFAPEPSSGMGLDLAVGHLDSMDWLELSSGGPVLSLAPLSTAAPSLFSMDFLDGHDLQLHWDSCL", "length": 964 }, "evidence": [ { "id": "E1BDD9", "url": "https://omabrowser.org/oma/group/E1BDD9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q969V6-1", "protein_name": "Myocardin-related transcription factor A", "gene_name": "MRTFA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLKLKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEAIIVGQVNYPKVADSSSFDEDSSDALSPEQPASHESQGSVPSPLEARVSEPLLSATSASPTQVVSQLPMGRDSREMLFLAEQPPLPPPPLLPPSLTNGTTIPTAKSTPTLIKQSQPKSASEKSQRSKKAKELKPKVKKLKYHQYIPPDQKQDRGAPPMDSSYAKILQQQQLFLQLQILNQQQQQHHNYQAILPAPPKSAGEALGSSGTPPVRSLSTTNSSSSSGAPGPCGLARQNSTSLTGKPGALPANLDDMKVAELKQELKLRSLPVSGTKTELIERLRAYQDQISPVPGAPKAPAATSILHKAGEVVVAFPAARLSTGPALVAAGLAPAEVVVATVASSGVVKFGSTGSTPPVSPTPSERSLLSTGDENSTPGDTFGEMVTSPLTQLTLQASPLQILVKEEGPRAGSCCLSPGGRAELEGRDKDQMLQEKDKQIEALTRMLRQKQQLVERLKLQLEQEKRAQQPAPAPAPLGTPVKQENSFSSCQLSQQPLGPAHPFNPSLAAPATNHIDPCAVAPGPPSVVVKQEALQPEPEPVPAPQLLLGPQGPSLIKGVAPPTLITDSTGTHLVLTVTNKNADSPGLSSGSPQQPSSQPGSPAPAPSAQMDLEHPLQPLFGTPTSLLKKEPPGYEEAMSQQPKQQENGSSSQQMDDLFDILIQSGEISADFKEPPSLPGKEKPSPKTVCGSPLAAQPSPSAELPQAAPPPPGSPSLPGRLEDFLESSTGLPLLTSGHDGPEPLSLIDDLHSQMLSSTAILDHPPSPMDTSELHFVPEPSSTMGLDLADGHLDSMDWLELSSGGPVLSLAPLSTTAPSLFSTDFLDGHDLQLHWDSCL", "length": 931 }, "evidence": [ { "id": "E1BDD9", "url": "https://omabrowser.org/oma/group/E1BDD9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "E1BDD9", "url": "https://www.uniprot.org/uniprotkb/E1BDD9" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "E1BDD9", "url": "https://www.uniprot.org/uniprotkb/E1BDD9" } ], "pmid": "" }, { "name": "actin monomer binding", "id": "GO:0003785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003785", "evidence": [ { "database": "UniProtKB", "id": "E1BDD9", "url": "https://www.uniprot.org/uniprotkb/E1BDD9" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "E1BDD9", "url": "https://www.uniprot.org/uniprotkb/E1BDD9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BDD9", "url": "https://www.uniprot.org/uniprotkb/E1BDD9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BDD9", "url": "https://www.uniprot.org/uniprotkb/E1BDD9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BDD9", "url": "https://www.uniprot.org/uniprotkb/E1BDD9" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "E1BDD9", "url": "https://www.uniprot.org/uniprotkb/E1BDD9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BDD9", "url": "https://www.uniprot.org/uniprotkb/E1BDD9" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "E1BDD9", "url": "https://www.uniprot.org/uniprotkb/E1BDD9" } ], "pmid": "" }, { "name": "smooth muscle cell differentiation", "id": "GO:0051145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051145", "evidence": [ { "database": "UniProtKB", "id": "E1BDD9", "url": "https://www.uniprot.org/uniprotkb/E1BDD9" } ], "pmid": "" }, { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "E1BDD9", "url": "https://www.uniprot.org/uniprotkb/E1BDD9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 419, "end_pos": 421, "annotation": "n_glycosylation_sequon" }, { "start_pos": 556, "end_pos": 558, "annotation": "n_glycosylation_sequon" }, { "start_pos": 929, "end_pos": 931, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDD9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1114, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDD9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDD9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDD9" }, { "id": "PS50800", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50800" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAP", "eco_id": "ECO_0000259", "start_pos": 434, "end_pos": 468, "start_aa": "Leu", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 543, 654 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 277, "end_pos": 279 }, { "start_pos": 419, "end_pos": 421 }, { "start_pos": 556, "end_pos": 558 }, { "start_pos": 929, "end_pos": 931 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDM5-1", "uniprot_ac": "E1BDM5", "uniprot_id": "E1BDM5_BOVIN", "mass": { "chemical_mass": 92664.0, "monoisotopic_mass": 92664.0 }, "refseq": { "ac": "NP_001179552", "name": "semaphorin-4C precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179552" }, "gene_names": [ { "name": "SEMA4C", "type": "recommended", "evidence": [ { "id": "E1BDM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ] }, { "name": "SEMA4C", "type": "synonym", "evidence": [ { "id": "NP_001179552", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179552" } ] } ], "protein_names": [ { "name": "Semaphorin-4C", "type": "recommended", "evidence": [ { "id": "E1BDM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM5/entry#names_and_taxonomy" } ] }, { "name": "sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C", "type": "synonym", "evidence": [ { "id": "NP_001179552", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179552" } ] }, { "name": "semaphorin-4C precursor", "type": "synonym", "evidence": [ { "id": "NP_001179552", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179552" } ] } ], "function": [ { "annotation": "Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5#function" }, { "database": "UniProtKB", "id": "ARBA00055175", "url": "https://www.uniprot.org/uniprotkb/ARBA00055175#function" }, { "database": "UniProtKB", "id": "A0A3Q1LRI4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRI4#function" }, { "database": "UniProtKB", "id": "A0AAA9SJ60", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ60#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SEMA4C", "url": "https://www.uniprot.org/uniprotkb/E1BDM5", "locus": { "chromosome": "11", "start_pos": 2816521, "end_pos": 2826076, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021920", "url": "https://www.ensembl.org/id/ENSBTAG00000021920" } ] } } ], "crossref": [ { "id": "E1BDM5", "url": "https://alphafold.ebi.ac.uk/entry/E1BDM5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021920", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021920", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11258", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11258", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "526028", "url": "https://www.ncbi.nlm.nih.gov/gene/526028", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002165", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002165", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027231", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027231", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526028", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526028", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SAICEYQ", "url": "https://omabrowser.org/oma/group/SAICEYQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LRI4", "url": "https://www.orthodb.org/?gene=A0A3Q1LRI4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BDM5", "url": "https://www.orthodb.org/?gene=E1BDM5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11036", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11036", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11036:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11036:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01403", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01403", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01437", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01437", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF28354", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28354", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179552", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRI4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRI4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRI4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ60", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ60", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ60-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ60-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDM5-1", "url": "https://www.uniprot.org/uniprotkb/E1BDM5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPHWAVWLLVLELWGLGLGAEVWWNLVPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEQTGLLYVGAREALFAFSVEALELQGVISWEAPVEKKAECIQKGKSNQTECFNFIRFLQPYNTSHLYVCGTYAFQPKCTYIDMLTFTLERSEFEDGKGKCPYDPAKGHTGLLVDGELYSATLNNFLGTEPVILRNMGPHHAMKTEYLAFWLNEPHFVGSAYVPESVGSYTGDDDKVYFFFSERAVEYDCYAEQVVARVARVCKGDVGGARTLQRKWTTFLKARLVCSAPDWQLYFNRLQALHTLQDASWHNTTFFGVFRARWGDMDLSAVCEYQLEEIQKVFEGPYKEYHEQAQKWGRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFIKKHPLMEEQVRPRWGRPLLVKKNANLTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLFDQEPVESLVLSRSKKLLFAGSRSQLVQLPPADCMKYRSCADCVLARDPYCAWNANSSRCVAVGGHSGSLLIQHVTVSDTSSICNFRGSKKVRLTPKNITVVAGTDLVLPCRLSSNLAHARWTFGGRDLPAEQPGSFLYDARLQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYLVAVVAGPSVTLEARAPLENLGLVWLAVVALGAVCLVLLLLVLSLRRRLREELEKGAKAAERTLVYPLELPKEPTSTPFRPGPETDEKLWDPVGYYYSDGSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGGGRNSNANGYVRLQLGGEDRGGLGHPLPELADELRRKLQQRQPLPDSNPEESSV", "length": 833, "header": "tr|E1BDM5-1|E1BDM5_BOVIN Isoform 1 of Semaphorin-4C OS=Bos taurus OX=9913 GN=SEMA4C PE=3 SV=4 CANONICAL=E1BDM5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRI4-1", "url": "https://www.uniprot.org/uniprotkb/E1BDM5/entry#A0A3Q1LRI4-1", "sequence": { "sequence": "MWNGVLGSARLLSALGEGRGWTATPAGLMHRVLSGAFPTACPTYSRAAGLELGARACAMAPHWAVWLLVLELWGLGLGAEVWWNLVPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEQTGLLYVGAREALFAFSVEALELQGVISWEAPVEKKAECIQKGKSNQTECFNFIRFLQPYNTSHLYVCGTYAFQPKCTYIDMLTFTLERSEFEDGKGKCPYDPAKGHTGLLVDGELYSATLNNFLGTEPVILRNMGPHHAMKTEYLAFWLNEPHFVGSAYVPESVGSYTGDDDKVYFFFSERAVEYDCYAEQVVARVARVCKGDVGGARTLQRKWTTFLKARLVCSAPDWQLYFNRLQALHTLQDASWHNTTFFGVFRARWGDMDLSAVCEYQLEEIQKVFEGPYKEYHEQAQKWGRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFIKKHPLMEEQVRPRWGRPLLVKKNANLTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLFDQEPVESLVLSRSKKLLFAGSRSQLVQLPPADCMKYRSCADCVLARDPYCAWNANSSRCVAVGGHSGSLLIQHVTVSDTSSICNFRGSKKVRLTPKNITVVAGTDLVLPCRLSSNLAHARWTFGGRDLPAEQPGSFLYDARLQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYLVAVVAGPSVTLEARAPLENLGLVWLAVVALGAVCLVLLLLVLSLRRRLREELEKGAKAAERTLVYPLELPKEPTSTPFRPGPETDEKLWDPVGYYYSDGSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGGGRNSNANGYVRLQLGGEDRGGLGHPLPELADELRRKLQQRQPLPDSNPEESSV", "length": 891, "header": "tr|A0A3Q1LRI4-1|E1BDM5_BOVIN Computationally mapped isoform of Semaphorin-4C OS=Bos taurus OX=9913 GN=SEMA4C PE=3 SV=2 CANONICAL=E1BDM5-1" }, "locus": { "chromosome": "11", "start_pos": 2824466, "end_pos": 2817426, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070843.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070843.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059616.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059616.2" } ] } }, { "isoform_ac": "A0AAA9SJ60-1", "url": "https://www.uniprot.org/uniprotkb/E1BDM5/entry#A0AAA9SJ60-1", "sequence": { "sequence": "MGLRVPGGGGPSYYPVHARDLFQAPELPPAPPPPTESLGRAWTEADVVRSDFPAAAPGRAPAPLGRRAVLESQAPEPRRPVPAGALALQLLGRRPQPAARGGQGWGSRRRDPAPLYTPPPPGAARFRRPGRSSAGRASERAAGSGLGLGAAGLELGARACAMAPHWAVWLLVLELWGLGLGAEVWWNLVPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEQTGLLYVGAREALFAFSVEALELQGVISWEAPVEKKAECIQKGKSNQTECFNFIRFLQPYNTSHLYVCGTYAFQPKCTYIDMLTFTLERSEFEDGKGKCPYDPAKGHTGLLVDGELYSATLNNFLGTEPVILRNMGPHHAMKTEYLAFWLNEPHFVGSAYVPESVGSYTGDDDKVYFFFSERAVEYDCYAEQVVARVARVCKGDVGGARTLQRKWTTFLKARLVCSAPDWQLYFNRLQALHTLQDASWHNTTFFGVFRARWGDMDLSAVCEYQLEEIQKVFEGPYKEYHEQAQKWGRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFIKKHPLMEEQVRPRWGRPLLVKKNANLTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLFDQEPVESLVLSRSKKLLFAGSRSQLVQLPPADCMKYRSCADCVLARDPYCAWNANSSRCVAVGGHSGSLLIQHVTVSDTSSICNFRGSKKVRLTPKNITVVAGTDLVLPCRLSSNLAHARWTFGGRDLPAEQPGSFLYDARLQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYLVAVVAGPSVTLEARAPLENLGLVWLAVVALGAVCLVLLLLVLSLRRRLREELEKGAKAAERTLVYPLELPKEPTSTPFRPGPETDEKLWDPVGYYYSDGSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGGGRNSNANGYVRLQLGGEDRGGLGHPLPELADELRRKLQQRQPLPDSNPEESSV", "length": 994, "header": "tr|A0AAA9SJ60-1|E1BDM5_BOVIN Computationally mapped isoform of Semaphorin-4C OS=Bos taurus OX=9913 GN=SEMA4C PE=3 SV=1 CANONICAL=E1BDM5-1" }, "locus": { "chromosome": "11", "start_pos": 2825607, "end_pos": 2817426, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091414.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091414.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086291.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086291.1" } ] } }, { "isoform_ac": "E1BDM5-1", "url": "https://www.uniprot.org/uniprotkb/E1BDM5/entry#E1BDM5-1", "sequence": { "sequence": "MAPHWAVWLLVLELWGLGLGAEVWWNLVPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEQTGLLYVGAREALFAFSVEALELQGVISWEAPVEKKAECIQKGKSNQTECFNFIRFLQPYNTSHLYVCGTYAFQPKCTYIDMLTFTLERSEFEDGKGKCPYDPAKGHTGLLVDGELYSATLNNFLGTEPVILRNMGPHHAMKTEYLAFWLNEPHFVGSAYVPESVGSYTGDDDKVYFFFSERAVEYDCYAEQVVARVARVCKGDVGGARTLQRKWTTFLKARLVCSAPDWQLYFNRLQALHTLQDASWHNTTFFGVFRARWGDMDLSAVCEYQLEEIQKVFEGPYKEYHEQAQKWGRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFIKKHPLMEEQVRPRWGRPLLVKKNANLTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLFDQEPVESLVLSRSKKLLFAGSRSQLVQLPPADCMKYRSCADCVLARDPYCAWNANSSRCVAVGGHSGSLLIQHVTVSDTSSICNFRGSKKVRLTPKNITVVAGTDLVLPCRLSSNLAHARWTFGGRDLPAEQPGSFLYDARLQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYLVAVVAGPSVTLEARAPLENLGLVWLAVVALGAVCLVLLLLVLSLRRRLREELEKGAKAAERTLVYPLELPKEPTSTPFRPGPETDEKLWDPVGYYYSDGSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGGGRNSNANGYVRLQLGGEDRGGLGHPLPELADELRRKLQQRQPLPDSNPEESSV", "length": 833, "header": "tr|E1BDM5-1|E1BDM5_BOVIN Isoform 1 of Semaphorin-4C OS=Bos taurus OX=9913 GN=SEMA4C PE=3 SV=4 CANONICAL=E1BDM5-1" }, "locus": { "chromosome": "11", "start_pos": 2823866, "end_pos": 2817426, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029225.6", "url": "https://www.ensembl.org/id/ENSBTAT00000029225.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029225.6", "url": "https://www.ensembl.org/id/ENSBTAP00000029225.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:526028", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526028", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A096MJS2-1", "protein_name": "Semaphorin-4C", "gene_name": "Sema4c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTAHAYRAAGLKFRLWVSAMAPHWAVWLLAAGLWGLGIGAEMWWNLAPRKTVSSGELVTVVRRFSQTGIQDFLTLTLTDRSGLLYVGAREALFAFSVEALELQGVISWEAPAEKKIECTQKGKSNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYINMLTFTLDRAEFEDGKGKCPYDPAKGHTGLLVDGELYSATLNNFLGTEPVILRNMGPHHPIKTEYLAFWLNEPHFVGSAFVPESVGSFTGDDDKIYFFFSERAVEYDCYSEQVVARVARVCKGDMGGARTLQKKWTTFLKARLVCSAPDWKVYFNQLRAVHTLLGASWHNTTFFAVFQARWGDMDLSAVCEYQLEHIQQVFEGPFKEYSEQAQKWARYTDPVPTPRPGSCINNWHRDNGYTSSLELPDNTLNFIKKHPLMEEQVKPRLGRPLLVKKNTNFTHVVADRILGLDGATYTVLFIGTGDGWLLKAVSLGPWIHMVEELQVFDQEPVESLVLSQSKKVLFAGSRSQLVQLSLADCTKYRFCVDCVLARDPYCAWNVNTSRCVATGGHSGSLLVQHVANLDPSKMCIQYAIKKARPVVPKNITVVAGTDLVLPCHLSSNLAHALWTFRGRDLPAEQPGSFLYDTGLQALVVMAAQSRHSGPYHCYSEEQGTKLAAESYLVSVVAGSSVTLEARAPLENLGLVWLAVVALGAVCLVLLLLVLSLRRRLREELEKGSKAAERTLVYPLELPKEPASPPFRPGPETDEKLWDPVGYYYSDGSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGGGRNSNANGYVRLQLGGEDREGSGHPLPEIADELRRKLQQRQPLPDSNPEESSV", "length": 853 }, "evidence": [ { "id": "E1BDM5", "url": "https://omabrowser.org/oma/group/E1BDM5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0ZKQ5-1", "protein_name": "Semaphorin 4C", "gene_name": "LOC107049953", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAPRLLLAIAWLLPLIPSATPGSSWSAVPRKTVPYAELRDAARRFSRGGVSHYVTLTLDEAEALLYVGAREAVFALSTGTVELKAAISWEAPVEKKAECIQKGKNNQTDCFNYVRFLQSYNSSHLYACGTYAFQPKCAYIELSGFTLDHVAFEDGKGKCPYDPTKGHTGLIVDGELYSATFNNFLGTEPVILRNLGPHYSMKTEYLTSWLNEPHFVASAYIQESAGSSTGDDDKVYFFFSERAVEYDCYAEQVVARVARVCKGDVGGARTLQKKWTTFLKARLLCSAPEQQLHFNRLQAVFTLPGDRWQETAFFGVFQARWGDVDVSAVCRYHILEVKKAFEGPYKEYREQAQKWGRYSDEVPSPRPGACITDWHRQNGFPSSLALPDNTLNFAKKHPLMDEPVLPQRGRPLLLKKDSNFTQLAVDRVAGLDGAVYEVLFVGTGDGWVHKALNLGSHVHLVEELQVFEPAQPVESLVLAGRKKLLFAGSRLQVAQLPVADCGRYQSCADCVLARDPYCAWSRNGSRCVRSDGLNGSHLVQDVLGSDTRACAMPLVGTQGAITPKNVTVAAGTDLVLTCRLGSNLAQALWTFEGRALPAQQALVLHDGHLRALVVPGAGAQHSGTYRCVAEERGARLGGEAYRVAVLPGAPQETRAPLESAGLAWVVAVCLGAACLVLLLAVLSLWRRLREELRKGAKAIESTLVYPIELPKEPHSPRFVPSAASDSDEKLWDPASYYCSDGSLKIVPGHAVCRNGGPPGAASPPAAIPGQPLHSPTRIHLGPLRGSSSNGYIRLALGAEERPPCAELAEELRRKLQQRQPLPDSNPEESSV", "length": 831 }, "evidence": [ { "id": "E1BDM5", "url": "https://omabrowser.org/oma/group/E1BDM5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7EY52-1", "protein_name": "Semaphorin-4C", "gene_name": "Sema4c", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTAHAYCLLTQLLSLLLWETPGAPGGQRPVAETSRTAGLKFRAWVFAMAPHWAVWLMAAGLWGLGIGAEVWWNLAPRKTVSSGELATVVRRFSLPGVQDFLTLTLREHSGLLYVGAREALFSFSIEALDLRGAITWRAPTEKKIECTRKGKSNQTECFNFICFLQPYNTSHLYVCGTYAFQPKCTYINKLSFKLKREELEDGKGKCPYDPAKGHTGLLVDGEMFSATLNNFLGTEPIILRNMGPHHPVKTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFSERAVEYDCYAEQVVARVARVCKGDMGGARTLQKKWTTFLKAQLACAAPDWKVYFNQLRSVHTLLGASWQNTTFFGVFQARWGDMDLSAVCEYQLEQIQQVFEGPYKEYSEQAQKWARYTDPVPSPRPGSCINNWHRHNGYTSSLELPDNILNFIKKHPLMEDQVQPRWGRPLLVKKNTNFTHMAADRVTGLDGATYTVLFIGTGDGWLLKAVNLGPWIHVIEELQVFDQEPVGSLVLSQSQKMLFAGSHSQLVQLPLADCTKYHLCADCVLARDPYCAWNVNTSRCVATFGDHSGSLLVQQVTNLDTSKLCNQYGIKKVRPTSKNITVVAGTDLVLPCHLSSNLARAHWTFKNQDLPAEQPGSFLYDPGLQVLVVMAAQPRHAGLYRCYLEEQGTRLPAESYRVTVVAGPSVTLEARAPLENLGLVWLAVVALGAVCLVLLLLVLSLRRRLREQLEKGAKAAERTLVYPLELPKETTSPPFRPGPETDEKLWDPVGYYYSDGSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGGGRNSNANGYVRLQLGGEDREGLGHPLPELADELRRKLQQRQPLPDSNPEESSV", "length": 881 }, "evidence": [ { "id": "E1BDM5", "url": "https://omabrowser.org/oma/group/E1BDM5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q64151-1", "protein_name": "Semaphorin-4C", "gene_name": "Sema4c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPHWAVWLLAAGLWGLGIGAEMWWNLVPRKTVSSGELVTVVRRFSQTGIQDFLTLTLTEHSGLLYVGAREALFAFSVEALELQGAISWEAPAEKKIECTQKGKSNQTECFNFIRFLQPYNSSHLYVCGTYAFQPKCTYINMLTFTLDRAEFEDGKGKCPYDPAKGHTGLLVDGELYSATLNNFLGTEPVILRYMGTHHSIKTEYLAFWLNEPHFVGSAFVPESVGSFTGDDDKIYFFFSERAVEYDCYSEQVVARVARVCKGDMGGARTLQKKWTTFLKARLVCSAPDWKVYFNQLKAVHTLRGASWHNTTFFGVFQARWGDMDLSAVCEYQLEQIQQVFEGPYKEYSEQAQKWARYTDPVPSPRPGSCINNWHRDNGYTSSLELPDNTLNFIKKHPLMEDQVKPRLGRPLLVKKNTNFTHVVADRVPGLDGATYTVLFIGTGDGWLLKAVSLGPWIHMVEELQVFDQEPVESLVLSQSKKVLFAGSRSQLVQLSLADCTKYRFCVDCVLARDPYCAWNVNTSRCVATTSGRSGSFLVQHVANLDTSKMCNQYGIKKVRSIPKNITVVSGTDLVLPCHLSSNLAHAHWTFGSQDLPAEQPGSFLYDTGLQALVVMAAQSRHSGPYRCYSEEQGTRLAAESYLVAVVAGSSVTLEARAPLENLGLVWLAVVALGAVCLVLLLLVLSLRRRLREELEKGAKASERTLVYPLELPKEPASPPFRPGPETDEKLWDPVGYYYSDGSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGGGRNSNANGYVRLQLGGEDRGGSGHPLPELADELRRKLQQRQPLPDSNPEESSV", "length": 834 }, "evidence": [ { "id": "E1BDM5", "url": "https://omabrowser.org/oma/group/E1BDM5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9C0C4-1", "protein_name": "Semaphorin-4C", "gene_name": "SEMA4C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPHWAVWLLAARLWGLGIGAEVWWNLVPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARLACSAPNWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLFDQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLLIQHVMTSDTSGICNLRGSKKVRPTPKNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLYDARLQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYLVAVVAGPSVTLEARAPLENLGLVWLAVVALGAVCLVLLLLVLSLRRRLREELEKGAKATERTLVYPLELPKEPTSPPFRPCPEPDEKLWDPVGYYYSDGSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGGGRNSNANGYVRLQLGGEDRGGLGHPLPELADELRRKLQQRQPLPDSNPEESSV", "length": 833 }, "evidence": [ { "id": "E1BDM5", "url": "https://omabrowser.org/oma/group/E1BDM5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "pmid": "" }, { "name": "synaptic vesicle membrane", "id": "GO:0030672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030672", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "pmid": "" }, { "name": "postsynaptic density membrane", "id": "GO:0098839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098839", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "semaphorin receptor binding", "id": "GO:0030215", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030215", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "pmid": "" }, { "name": "neuropilin binding", "id": "GO:0038191", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038191", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "pmid": "" }, { "name": "chemorepellent activity", "id": "GO:0045499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045499", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "pmid": "" }, { "name": "semaphorin-plexin signaling pathway", "id": "GO:0071526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071526", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "pmid": "" }, { "name": "neural crest cell migration", "id": "GO:0001755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001755", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "pmid": "" }, { "name": "negative chemotaxis", "id": "GO:0050919", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050919", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "pmid": "" }, { "name": "muscle cell differentiation", "id": "GO:0042692", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042692", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "pmid": "" }, { "name": "neural tube closure", "id": "GO:0001843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001843", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "pmid": "" }, { "name": "cerebellum development", "id": "GO:0021549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021549", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "pmid": "" }, { "name": "cell migration in hindbrain", "id": "GO:0021535", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021535", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "pmid": "" }, { "name": "positive regulation of stress-activated MAPK cascade", "id": "GO:0032874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032874", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "pmid": "" }, { "name": "regulation of postsynapse assembly", "id": "GO:0150052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150052", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "E1BDM5", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 310, "end_pos": 312, "annotation": "n_glycosylation_sequon" }, { "start_pos": 419, "end_pos": 421, "annotation": "n_glycosylation_sequon" }, { "start_pos": 522, "end_pos": 524, "annotation": "n_glycosylation_sequon" }, { "start_pos": 564, "end_pos": 566, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDM5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 833, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDM5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDM5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 556, "end_pos": 637, "start_aa": "Lys", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BDM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM5" }, { "id": "PS51004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sema", "eco_id": "ECO_0000259", "start_pos": 30, "end_pos": 497, "start_aa": "Arg", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BBW7-1", "uniprot_ac": "E1BBW7", "uniprot_id": "E1BBW7_BOVIN", "mass": { "chemical_mass": 51303.0, "monoisotopic_mass": 51303.0 }, "refseq": { "ac": "XP_002696040", "name": "reticulophagy regulator 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696040" }, "gene_names": [ { "name": "RETREG3", "type": "recommended", "evidence": [ { "id": "E1BBW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBW7" } ] }, { "name": "RETREG3", "type": "synonym", "evidence": [ { "id": "XP_002696040", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696040" } ] } ], "protein_names": [ { "name": "Reticulophagy regulator family member 3", "type": "synonym", "evidence": [ { "id": "E1BBW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBW7/entry#names_and_taxonomy" } ] }, { "name": "reticulophagy regulator 3", "type": "synonym", "evidence": [ { "id": "XP_002696040", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696040" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBW7", "url": "https://www.uniprot.org/uniprotkb/E1BBW7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RETREG3", "url": "https://www.uniprot.org/uniprotkb/E1BBW7", "locus": { "chromosome": "19", "start_pos": 42656792, "end_pos": 42678499, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032493", "url": "https://www.ensembl.org/id/ENSBTAG00000032493" } ] } } ], "crossref": [ { "id": "E1BBW7", "url": "https://alphafold.ebi.ac.uk/entry/E1BBW7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032493", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032493", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22562", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22562", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "789163", "url": "https://www.ncbi.nlm.nih.gov/gene/789163", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR043384", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043384", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055258", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055258", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:789163", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789163", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HRVFQHV", "url": "https://omabrowser.org/oma/group/HRVFQHV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LV12", "url": "https://www.orthodb.org/?gene=A0A3Q1LV12", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BBW7", "url": "https://www.orthodb.org/?gene=E1BBW7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28659", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28659", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28659:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28659:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF24456", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24456", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002696040", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696040", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV12", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV12-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV12-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLL1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLL1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBW7", "url": "https://www.uniprot.org/uniprotkb/E1BBW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBW7-1", "url": "https://www.uniprot.org/uniprotkb/E1BBW7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEAEGVAEAPGPASGQTFKGRRPMSGSWERDQQVEAAHRALVEVLGPYEPLLSRVQAALVWERPARSALWCLGLNAAFWFFALTSLRLVFLLAFSSMIIVCIDQWKNKIWPEIKVPRPGVLDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNLLLFKKQNPGKFCLLSCGILTFLAVLGRYIPGLLLSYLILVTVMMWPLAVYHRLWDRVYVRLKPALQRLDFSVRGYMMSKQRERQLRRRALHPERAADNHSDSEEELAAFCPQLDDSTVARELAITDSEHSDAEVSCTDNGTFNLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFPSINVDPTGLDDEDDTSIGMPSLMYRSPPGAGESQGPPASREEAALPELLLGALPAGSNLTSNLASLVSQGMIQLALSGASQPGPSGLPPRRATRGVLRAPSSDLDTDAEGDDFELLDQSELNQLDPASSRSH", "length": 466, "header": "tr|E1BBW7-1|E1BBW7_BOVIN Isoform 1 of Reticulophagy regulator family member 3 OS=Bos taurus OX=9913 GN=RETREG3 PE=3 SV=1 CANONICAL=E1BBW7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LV12-1", "url": "https://www.uniprot.org/uniprotkb/E1BBW7/entry#A0A3Q1LV12-1", "sequence": { "sequence": "MIIVCIDQWKNKIWPEIKVPRPGVLDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNLLLFKKQNPGKFCLLSCGILTFLAVLGRYIPGLLLSYLILVTVMMWPLAVYHRLWDRVYVRLKPALQRLDFSVRGYMMSKQRERQLRRRALHPERAADNHSDSEEELAAFCPQLDDSTVARELAITDSEHSDAEVSCTDNGTFNLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFPSINVDPTGLDDEDDTSIGMPSLMYRSPPGAGESQGPPASREEAALPELLLGALPAGSNLTSNLASLVSQGMIQLALSGASQPGPSGLPPRRATRGVLRAPSSDLDTDAEGDDFELLDQSELNQLDPASSRSH", "length": 369, "header": "tr|A0A3Q1LV12-1|E1BBW7_BOVIN Computationally mapped isoform of Reticulophagy regulator family member 3 OS=Bos taurus OX=9913 GN=RETREG3 PE=3 SV=2 CANONICAL=E1BBW7-1" }, "locus": { "chromosome": "19", "start_pos": 42664401, "end_pos": 42657796, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073713.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073713.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061202.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061202.2" } ] } }, { "isoform_ac": "A0AAA9SLL1-1", "url": "https://www.uniprot.org/uniprotkb/E1BBW7/entry#A0AAA9SLL1-1", "sequence": { "sequence": "MPCCCSVAKSCPAVWYPMNCSMPGFPVLHCLPEQGGFPELPWLLFLFLFFLPKVFICSDFKVGCFLSINIRFFALTSLRLVFLLAFSSMIIVCIDQWKNKIWPEIKVPRPGVLDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNLLLFKKQNPGKFCLLSCGILTFLAVLGRYIPGLLLSYLILVTVMMWPLAVYHRLWDRVYVRLKPALQRLDFSVRGYMMSKQRERQLRRRALHPERAADNHSDSEEELAAFCPQLDDSTVARELAITDSEHSDAEVSCTDNGTFNLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFPSINVDPTGLDDEDDTSIGMPSLMYRSPPGAGESQGPPASREEAALPELLLGALPAGSNLTSNLASLVSQGMIQLALSGASQPGPSGLPPRRATRGVLRAPSSDLDTDAEGDDFELLDQSELNQLDPASSRSH", "length": 457, "header": "tr|A0AAA9SLL1-1|E1BBW7_BOVIN Computationally mapped isoform of Reticulophagy regulator family member 3 OS=Bos taurus OX=9913 GN=RETREG3 PE=3 SV=1 CANONICAL=E1BBW7-1" }, "locus": { "chromosome": "19", "start_pos": 42672178, "end_pos": 42657796, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101052.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101052.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084810.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084810.1" } ] } }, { "isoform_ac": "E1BBW7-1", "url": "https://www.uniprot.org/uniprotkb/E1BBW7/entry#E1BBW7-1", "sequence": { "sequence": "MAEAEGVAEAPGPASGQTFKGRRPMSGSWERDQQVEAAHRALVEVLGPYEPLLSRVQAALVWERPARSALWCLGLNAAFWFFALTSLRLVFLLAFSSMIIVCIDQWKNKIWPEIKVPRPGVLDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNLLLFKKQNPGKFCLLSCGILTFLAVLGRYIPGLLLSYLILVTVMMWPLAVYHRLWDRVYVRLKPALQRLDFSVRGYMMSKQRERQLRRRALHPERAADNHSDSEEELAAFCPQLDDSTVARELAITDSEHSDAEVSCTDNGTFNLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFPSINVDPTGLDDEDDTSIGMPSLMYRSPPGAGESQGPPASREEAALPELLLGALPAGSNLTSNLASLVSQGMIQLALSGASQPGPSGLPPRRATRGVLRAPSSDLDTDAEGDDFELLDQSELNQLDPASSRSH", "length": 466, "header": "tr|E1BBW7-1|E1BBW7_BOVIN Isoform 1 of Reticulophagy regulator family member 3 OS=Bos taurus OX=9913 GN=RETREG3 PE=3 SV=1 CANONICAL=E1BBW7-1" }, "locus": { "chromosome": "19", "start_pos": 42675816, "end_pos": 42657796, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046079.4", "url": "https://www.ensembl.org/id/ENSBTAT00000046079.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043407.2", "url": "https://www.ensembl.org/id/ENSBTAP00000043407.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:789163", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789163", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BPH4-1", "protein_name": "Reticulophagy regulator family member 3", "gene_name": "RETREG3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAEAEGVVVAPGPASGQSSRGRRTMSGSCERDQQVEAAQRALVEVLGPYEPLLNRVQAALVWERPARSALWCLGLNAAFWFFALTSLRLVFLLAFSSMIIVCIDQWKNKIWPEIKVPRPDALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNLLLFKKQNPGKFCLLSCGILTFLAVLGRYIPGLLLSYFILVAAMMWPLAVYHRLWDRAYVRLKPALQRLDFSVRGYMMSKQRERQSRRRALHPERAVDNHSDSEEELAAFCPQLDDSTVARELAITDSEHSDAEVSCTDNGTFNLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFPSINVDPAGLDDEDDTSIGMPSLLYRSPPGAEAPQGPPASRDEAALPELLLGALPTGSSLTSNLASLVSQGMIQLALSGASQPGPAGLPPRRAARGFLRAPSSDLDTDAEGDDFELLDQSELNQLDPASSRSH", "length": 466 }, "evidence": [ { "id": "E1BBW7", "url": "https://omabrowser.org/oma/group/E1BBW7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A3Q2UKZ0-1", "protein_name": "RETREG1-3/ARL6IP-like N-terminal reticulon-homology domain-containing protein", "gene_name": "FAM134C", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAARPGERQRRVQELSAALRGRLGPYERLLSAAQAALVWERPGRSALWWAAAHGLFWFFALTSLRLVFLVALTLIVVVCLDQWKNKIWPEIGVARPDELDNESWGYVHPRLLGVPELCHHLAEGWVSWTNFLSNLFVFKRQSPGKFCLLVCGVFTFLAVLGRYIPGLLLSYLLLLFILLWPLAVYHRLGHRMYMKLEPALQRLDFSVRGYMISKQREKQLRRRSINQEGTDDGSDSEEELAAFCPKLDDSVVAKELTISDSEHSDAEVSYTENGMFNLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFPSINPEVTGLDDEDDTSIGIPSLAYRPQVTEDVHLPYYQEEAGVLPSVQNLTNNIAGFVTRGMIQLALSGATQPGSSRSDNLHRDAKTYLRTASLDLDTDVEGDDFELLDQSELNQLDPAGSRGQ", "length": 435 }, "evidence": [ { "id": "E1BBW7", "url": "https://omabrowser.org/oma/group/E1BBW7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1QYM7-1", "protein_name": "Reticulophagy regulator 3", "gene_name": "retreg3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAGGAEEATEASGCAGRLRSSGGLRSGSCSGGTSEQLRAVKTTLLERLGPHERLLTYLQSVLLWERPFHSVLLYTAANVTFWFFALSSLRLLFLLASSLALAVCVDTWRNKIWPKIRVKKQDESENESWGLVQPGTLSVPELCHHLAEIWVTGSTCATNIVQFKRHNPGKFCVLVCGLFTLVAMVGRYIPGLVLSYAALLGVLLCPLALYYRLWQRVCVKLEPALQWLDFSAKGYMMSKPLDNQFLRKPIRSGNSDDVSDSEEELAAFCPTFDEAVVAKELALTDSEHSDAEISYMDNGTFNLSRGQTPLTEGSEDLDRHSDPEESFACGLPDFPSINPDATLMEDDDDASIGLPSLNSAAPSGHRGSTSALLDLNTEMDSDQEDLELSLGSLNTTSDLTSNLAGVIASNMIQAAIAGAMQPRPPQGPRRESGPRAGAAPRGFRKQSSSELDTDLDYDGEDFEMLDQSELNQLDPFGGGQGGQNRTQGSSFLSNFLGKPQ", "length": 500 }, "evidence": [ { "id": "E1BBW7", "url": "https://omabrowser.org/oma/group/E1BBW7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q86VR2-1", "protein_name": "Reticulophagy regulator 3", "gene_name": "RETREG3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEAEGVPTTPGPASGSTFRGRRDVSGSWERDQQVEAAQRALVEVLGPYEPLLSRVQAALVWERPARSALWCLGLNAAFWFFALTSLRLVFLLAFGLMIIVCIDQWKNKIWPEIKVPRPDALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNVLLFKKQNPGKFCLLSCGILTFLAVLGRYVPGLLLSYLMLVTVMMWPLAVYHRLWDRAYVRLKPALQRLDFSVRGYMMSKQRERQLRRRALHPERAMDNHSDSEEELAAFCPQLDDSTVARELAITDSEHSDAEVSCTDNGTFNLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFPSINMDPAGLDDEDDTSIGMPSLMYRSPPGAEEPQAPPASRDEAALPELLLGALPVGSNLTSNLASLVSQGMIQLALSGASQPGPSGAPAQRATRGFLRSPSSDLDTDAEGDDFELLDQSELSQLDPASSRSH", "length": 466 }, "evidence": [ { "id": "E1BBW7", "url": "https://omabrowser.org/oma/group/E1BBW7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CQV4-1", "protein_name": "Reticulophagy regulator 3", "gene_name": "Retreg3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEAEGVAAAPGPASGLAFRGRRAMSGSWERDQQVEAAQRTLVEVLGPYEPLLSRVQAALVWERPARSALWCLGLNAAFWFFALTSLRFVFLLAFSLMIIVCIDQWKNKIWPEINVPRPDALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNLLLFKKQNPGKFCLLSCGVLTFLAMLGRYIPGLLLSYLMLVIIMMWPLAVYHRLWDRAYVRLKPVLQRLDFSVRGYMMSKQRERQLRRRALHSERATDSHSDSEEELAAFCPQLDDSTVARELAITDSEHSDAEVSCTENGTFNLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFPSINVDPAGLDDEDDTSIGMPSLMYRSPPGAGDTQVLPASRNEAALPELLLSSLPGGSNLTSNLASLVSQGMIQLALSEASQTDPSGPPPRRATRGFLRAPSSDLDTDAEGDDFELLDQSELNQLDPASSRSH", "length": 466 }, "evidence": [ { "id": "E1BBW7", "url": "https://omabrowser.org/oma/group/E1BBW7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "E1BBW7", "url": "https://www.uniprot.org/uniprotkb/E1BBW7" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "E1BBW7", "url": "https://www.uniprot.org/uniprotkb/E1BBW7" } ], "pmid": "" }, { "name": "endoplasmic reticulum tubular network", "id": "GO:0071782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071782", "evidence": [ { "database": "UniProtKB", "id": "E1BBW7", "url": "https://www.uniprot.org/uniprotkb/E1BBW7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "reticulophagy", "id": "GO:0061709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061709", "evidence": [ { "database": "UniProtKB", "id": "E1BBW7", "url": "https://www.uniprot.org/uniprotkb/E1BBW7" } ], "pmid": "" }, { "name": "endoplasmic reticulum tubular network organization", "id": "GO:0071786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071786", "evidence": [ { "database": "UniProtKB", "id": "E1BBW7", "url": "https://www.uniprot.org/uniprotkb/E1BBW7" } ], "pmid": "" }, { "name": "positive regulation of neuron projection development", "id": "GO:0010976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010976", "evidence": [ { "database": "UniProtKB", "id": "E1BBW7", "url": "https://www.uniprot.org/uniprotkb/E1BBW7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum-autophagosome adaptor activity", "id": "GO:0140506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140506", "evidence": [ { "database": "UniProtKB", "id": "E1BBW7", "url": "https://www.uniprot.org/uniprotkb/E1BBW7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" }, { "start_pos": 297, "end_pos": 299, "annotation": "n_glycosylation_sequon" }, { "start_pos": 301, "end_pos": 303, "annotation": "n_glycosylation_sequon" }, { "start_pos": 392, "end_pos": 394, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBW7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 466, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBW7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBW7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBW7" }, { "id": "PF24456", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24456" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RETREG1-3/ARL6IP-like N-terminal reticulon-homology", "eco_id": "ECO_0000259", "start_pos": 47, "end_pos": 230, "start_aa": "Gly", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 124, "end_pos": 126 }, { "start_pos": 256, "end_pos": 258 }, { "start_pos": 297, "end_pos": 299 }, { "start_pos": 301, "end_pos": 303 }, { "start_pos": 392, "end_pos": 394 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BBM9-1", "uniprot_ac": "E1BBM9", "uniprot_id": "E1BBM9_BOVIN", "mass": { "chemical_mass": 81183.0, "monoisotopic_mass": 81183.0 }, "refseq": {}, "gene_names": [ { "name": "LOC100847151", "type": "recommended", "evidence": [ { "id": "E1BBM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM9" } ] } ], "protein_names": [ { "name": "Disintegrin and metalloproteinase domain-containing protein 5-like", "type": "recommended", "evidence": [ { "id": "E1BBM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBM9", "url": "https://www.uniprot.org/uniprotkb/E1BBM9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC100847151", "url": "https://www.uniprot.org/uniprotkb/E1BBM9", "locus": {} } ], "crossref": [ { "id": "E1BBM9", "url": "https://alphafold.ebi.ac.uk/entry/E1BBM9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040445", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040445", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04269", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04269", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001762", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001762", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006586", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006586", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018358", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018358", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034027", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034027", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DKTDTCH", "url": "https://omabrowser.org/oma/group/DKTDTCH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11905", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11905", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11905:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11905:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00200", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00200", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01421", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01421", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LXN6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXN6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXN6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBM9", "url": "https://www.uniprot.org/uniprotkb/E1BBM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBM9-1", "url": "https://www.uniprot.org/uniprotkb/E1BBM9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFLLLVLLTVLRGLHGDLHKKFVQTTIPEKISTSEAIKDPENNMFFLHLSFLSSASVVYFYDKNDIQHHQPLSAQMDCNYHGYVAGFPNSLVSLNICSGLRLGTLQFKNISYALEPVESVLGFMHMIYEEKNDISAIPLLLENDTYSYERSQYKVRKSSERSGHTKLFPRYIDMYIVVDKNLFDYMGSDINIVTQKIIQIIGLVNTMFIQLKLTVRISSIEVWSDKNKISIEGPPHSVLYKFLTWKYEFTSRPHHIAYLFAFKENPTFIGVTVPGEICGKIAVGGVALYIEGLSLEAYAVSIVQLLGLNVGMSYDNTEICHCSGDVCTMSPEALQSGGVKDFSTCSLDDFKYFAAYTGIECLHKILPDEPVYKQRRVCGNGILETGEQCDCGTPQTCTHPDCCDARLCTKKKNKVCGSGACCTTSCQIKPVNTPCREAADECDFVEFCTGNESMCVPDTYARNGEPCASGDAFCYDGRCRSTNKHCSRLIGEGARGAPFACFDEINARGDRYGNCGRGFCLFSHTLCGKLVCAWPYKTLVSQPNLSVIYTHVQDEICASAFLNAEKLPRDTFTTVQKPEDRDETFVEDGTICGPEMYCLNFSCVEVKYQINTTICSNAVHCNSKGVCNNLNHCHCSMGFAPPNCKPLPEAFGSVDDGHQHKTGKSFLKERSLGHPKHRLQLVFYISIPVFIIAAALIIKQDKIRELCYKGELESESQEKSIHGSSRIC", "length": 728, "header": "tr|E1BBM9-1|E1BBM9_BOVIN Isoform 1 of Disintegrin and metalloproteinase domain-containing protein 5-like OS=Bos taurus OX=9913 GN=LOC100847151 PE=4 SV=3 CANONICAL=E1BBM9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXN6-1", "url": "https://www.uniprot.org/uniprotkb/E1BBM9/entry#A0A3Q1LXN6-1", "sequence": { "sequence": "KNDIQHHQPLSAQMDCNYHGYVAGFPNSLVSLNICSGLRLGTLQFKNISYALEPVESVLGFMHMIYEEKNDISAIPLLLENDTYSYERSQYKVRKSSEVSFDYMGSDINIVTQKIIQIIGLVNTMFIQLKLTVRISSIEVWSDKNKISIEGPPHSVLYKFLTWKYEFTSRPHHIAYLFAFKENPTFIGVTVPGEICGKIAVGGVALYIEGLSLEAYAVSIVQLLGLNVGMSYDNTEICHCSGDVCTMSPEALQSGGVKDFSTCSLDDFKYFAAYTGIECLHKILPDEPVYKQRRVCGNGILETGEQCDCGTPQTCTHPDCCDARLCTKKKNKVCGSGACCTTSCQVGVNTPCREAADECDFVEFCTGNESMCVPDTYARNGEPCASGDAFCYDGRCRSTNKHCSRLIGEGARGAPFACFDEINARGDRYGNCGRGFCLFSHTLCGKLVCAWPYKTLVSQPNLSVIYTHVQDEICASAFLNAEKLPRDTFTTVQKPEDRDETFVEDGTICGPEMYCLNFSCVEVKYQINTTICSNAVHCNSKGVCNNLNHCHCSMGFAPPNCKPLPEAFGSVDDGHQHKTGKSFLKERSLGHPKHRLQLVFYISIPVFIIAAALIIKQDKIRELCYKGELESERYICFILIK", "length": 641, "header": "tr|A0A3Q1LXN6-1|E1BBM9_BOVIN Computationally mapped isoform of Disintegrin and metalloproteinase domain-containing protein 5-like OS=Bos taurus OX=9913 GN=LOC100847151 PE=4 SV=2 CANONICAL=E1BBM9-1" }, "locus": { "chromosome": "27", "start_pos": 34550263, "end_pos": 34439694, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075054.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075054.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065550.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065550.2" } ] } }, { "isoform_ac": "E1BBM9-1", "url": "https://www.uniprot.org/uniprotkb/E1BBM9/entry#E1BBM9-1", "sequence": { "sequence": "MFLLLVLLTVLRGLHGDLHKKFVQTTIPEKISTSEAIKDPENNMFFLHLSFLSSASVVYFYDKNDIQHHQPLSAQMDCNYHGYVAGFPNSLVSLNICSGLRLGTLQFKNISYALEPVESVLGFMHMIYEEKNDISAIPLLLENDTYSYERSQYKVRKSSERSGHTKLFPRYIDMYIVVDKNLFDYMGSDINIVTQKIIQIIGLVNTMFIQLKLTVRISSIEVWSDKNKISIEGPPHSVLYKFLTWKYEFTSRPHHIAYLFAFKENPTFIGVTVPGEICGKIAVGGVALYIEGLSLEAYAVSIVQLLGLNVGMSYDNTEICHCSGDVCTMSPEALQSGGVKDFSTCSLDDFKYFAAYTGIECLHKILPDEPVYKQRRVCGNGILETGEQCDCGTPQTCTHPDCCDARLCTKKKNKVCGSGACCTTSCQIKPVNTPCREAADECDFVEFCTGNESMCVPDTYARNGEPCASGDAFCYDGRCRSTNKHCSRLIGEGARGAPFACFDEINARGDRYGNCGRGFCLFSHTLCGKLVCAWPYKTLVSQPNLSVIYTHVQDEICASAFLNAEKLPRDTFTTVQKPEDRDETFVEDGTICGPEMYCLNFSCVEVKYQINTTICSNAVHCNSKGVCNNLNHCHCSMGFAPPNCKPLPEAFGSVDDGHQHKTGKSFLKERSLGHPKHRLQLVFYISIPVFIIAAALIIKQDKIRELCYKGELESESQEKSIHGSSRIC", "length": 728, "header": "tr|E1BBM9-1|E1BBM9_BOVIN Isoform 1 of Disintegrin and metalloproteinase domain-containing protein 5-like OS=Bos taurus OX=9913 GN=LOC100847151 PE=4 SV=3 CANONICAL=E1BBM9-1" }, "locus": { "chromosome": "27", "start_pos": 34550308, "end_pos": 34425976, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017967.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017967.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017967.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017967.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q3TTE0-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 5", "gene_name": "Adam5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFLLLLLFLHLKGLQAGQNPQKTTLQTTVPEKISSPDVETDAEDHMAYLITINETPHFIHLKKQSFITPTAVVYTYDRNDVQHSQPLSALENCNYNGYVAGFPNSIVTLTVCTGLRGIIQFENVSYAIEPVETLSGFVHVIYENTNKHAVIPDLGKNQSYSWFDESDYQFRSNMKKSGFTVLRQRFIMMDIIVDKKLFDYMGSDTEVVLQKVIQIIGFVNTMLSKLKLTVLINSIEIWSKENRIRLSKAVDDLLVQFSIWKHEYRSQHVAYLLAFEEHPASTGALYPGNLCKLEYNAAVALYPKGLSLESFSVIVLQLLSIGMGLTYDTENCHCTGEVCLMTPKAIYSGGVKDFSTCTLDDFKYLSTRQDLRCLQDLPLERKPARRPRRICGNGILEMNEQCDCGTLKNCTHRKCCDPMSCRLKNKATCGSGECCSQDCTVKMNDVVCRKSVDECDFVEYCNGKDPYCVPNTYARNGQYCESGEAFCFEGRCQTADKQCMSMLGKYVRGASFACYEEFNSRGDRFGNCIHNFCAFRNSLCGKLICTWPFKKLVLKANLSVAYAQIRDDLCVAMYKGGRIPKTTKTTYSNPADRDETFVNDGTICGPDMFCLRASCTETRFHMDSSKCDSTRDCNDHGVCNNLQHCHCDIGYNPPFCEEHKGQFGSVDDGHKYHVEDGKSYKQQSHSNLKKNQLQLILYISLPLLVMISAVVIKQSKLSRVCDRERSESDSSTTEDSGSNTNVTSSGGSTSH", "length": 751 }, "evidence": [ { "id": "E1BBM9", "url": "https://omabrowser.org/oma/group/E1BBM9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5BK84-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 5", "gene_name": "Adam5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKTPISSILKSNGLGIFLYRSFITSTAVSYTYDRQDVRHSQSLSSLKNCNYNGYVAGFPNSIVSLTVCSGLRGMIQFENVSYGIEPVETLSGFIHVIYENTNQQAKIPDLGENQTYSWSDELDYQFRSNMKKSGFAVLRPRYIKTDIVVDKKLFDYMGSDTRVVLQKVIQIIGFINTMFSKLKLTVLINSVEIWSKENRIDFPEAPENLLVQFLHWKHKYRPQHISYLLAFVEHPASTGALYPGNLCKPIYGAAIALYPKGLSLESYSVIVLQLLSIGIGLTYDNADSCHCTGDVCLMTPKAIYSGGVKDFSTCSLDDFKYLSTQDLECLQDLPMERQKKKPSRPRRICGNGILEMNEQCDCGTLKNCTHKKCCDPMSCRLKSKAVCGSGECCGQDCKVKPVNVLCRKSKNECDFEEYCNGNDAYCVPDTFARNGQYCDSGQAFCYSGLCMTSNNQCMNLLGKYVRGASFACYEEFNSRNDRFGNCIRKFCSFENSLCGKLVCTWPFKRLLMKDNMSAAYGQIRDDLCISLYKGGRPLKTTLSTYSDMSERDETFVKDGTICGPDMFCLETQCKETRFLVDFQQCNTSRDCNDHGVCNNFNHCHCDKGYNPPYCESVKGQFGSIDDGHKYYIDEGKSAKQQNRGIHPKQQLQLILYITLPLIMIISAVFIKQSKLSRLCGRERSEGTSCITEDSVSNTKMTTNEGSTLH", "length": 709 }, "evidence": [ { "id": "E1BBM9", "url": "https://omabrowser.org/oma/group/E1BBM9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metalloendopeptidase activity", "id": "GO:0004222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "evidence": [ { "database": "UniProtKB", "id": "E1BBM9", "url": "https://www.uniprot.org/uniprotkb/E1BBM9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1BBM9", "url": "https://www.uniprot.org/uniprotkb/E1BBM9" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "E1BBM9", "url": "https://www.uniprot.org/uniprotkb/E1BBM9" } ], "pmid": "" }, { "name": "binding of sperm to zona pellucida", "id": "GO:0007339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007339", "evidence": [ { "database": "UniProtKB", "id": "E1BBM9", "url": "https://www.uniprot.org/uniprotkb/E1BBM9" } ], "pmid": "" }, { "name": "male gonad development", "id": "GO:0008584", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008584", "evidence": [ { "database": "UniProtKB", "id": "E1BBM9", "url": "https://www.uniprot.org/uniprotkb/E1BBM9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BBM9", "url": "https://www.uniprot.org/uniprotkb/E1BBM9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BBM9", "url": "https://www.uniprot.org/uniprotkb/E1BBM9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 143, "end_pos": 145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 451, "end_pos": 453, "annotation": "n_glycosylation_sequon" }, { "start_pos": 544, "end_pos": 546, "annotation": "n_glycosylation_sequon" }, { "start_pos": 600, "end_pos": 602, "annotation": "n_glycosylation_sequon" }, { "start_pos": 611, "end_pos": 613, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBM9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 728, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBM9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBM9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM9" }, { "id": "PS50214", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50214" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Disintegrin", "eco_id": "ECO_0000259", "start_pos": 375, "end_pos": 463, "start_aa": "Arg", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BBM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM9" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 611, "end_pos": 645, "start_aa": "Asn", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BBM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM9" }, { "id": "PS50215", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50215" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase M12B", "eco_id": "ECO_0000259", "start_pos": 170, "end_pos": 366, "start_aa": "Arg", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 111 }, { "start_pos": 143, "end_pos": 145 }, { "start_pos": 451, "end_pos": 453 }, { "start_pos": 544, "end_pos": 546 }, { "start_pos": 600, "end_pos": 602 }, { "start_pos": 611, "end_pos": 613 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B7B9-1", "uniprot_ac": "E1B7B9", "uniprot_id": "E1B7B9_BOVIN", "mass": { "chemical_mass": 51290.0, "monoisotopic_mass": 51290.0 }, "refseq": {}, "gene_names": [ { "name": "PIGA", "type": "recommended", "evidence": [ { "id": "E1B7B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7B9" } ] } ], "protein_names": [ { "name": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit A", "type": "recommended", "evidence": [ { "id": "E1B7B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7B9/entry#names_and_taxonomy" } ] }, { "name": "2.4.1.198", "type": "synonym", "evidence": [ { "id": "E1B7B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7B9/entry#names_and_taxonomy" } ] }, { "name": "GlcNAc-PI synthesis protein", "type": "synonym", "evidence": [ { "id": "E1B7B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7B9/entry#names_and_taxonomy" } ] }, { "name": "Phosphatidylinositol-glycan biosynthesis class A protein", "type": "synonym", "evidence": [ { "id": "E1B7B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7B9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalytic subunit of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.", "evidence": [ { "database": "UniProtKB", "id": "E1B7B9", "url": "https://www.uniprot.org/uniprotkb/E1B7B9#function" }, { "database": "UniProtKB", "id": "ARBA00058926", "url": "https://www.uniprot.org/uniprotkb/ARBA00058926#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7B9", "url": "https://www.uniprot.org/uniprotkb/E1B7B9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PIGA", "url": "https://www.uniprot.org/uniprotkb/E1B7B9", "locus": { "chromosome": "X", "start_pos": 128175289, "end_pos": 128163918, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007646", "url": "https://www.ensembl.org/id/ENSBTAG00000007646" } ] } } ], "crossref": [ { "id": "E1B7B9", "url": "https://alphafold.ebi.ac.uk/entry/E1B7B9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007646", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007646", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03796", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03796", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001296", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001296", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013234", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013234", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039507", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039507", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100139601", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100139601", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR45871", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45871", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45871:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45871:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00534", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00534", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08288", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08288", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13692", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13692", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-162710", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-162710", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "14789", "url": "https://www.rhea-db.org/rhea/14789", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LZ81", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZ81-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ81-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U112", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U112", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U112-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U112-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7B9", "url": "https://www.uniprot.org/uniprotkb/E1B7B9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7B9-1", "url": "https://www.uniprot.org/uniprotkb/E1B7B9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAYRGRGGRGQPSSASLSRVIPGSLHTFRTCAHNICMVSDFFYPNMGGVESHIYQLSQCLIERGHKVIIVTHAYGNRKGIRYLTNGLKVYYLPLKVMYNQSTATTLFHSLPLLRYIFVRERVTIIHSHSSFSAMAHDALFHAKTMGLQTVFTDHSLFGFADVSSVLTNKLLTVSLCDTNHIICVSYTSKENTVLRAALNPEIVSVIPNAVDPTDFTPDPFRRHDSIITIVVVSRLVYRKGTDLLSGIIPELCQKYPDLKFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLIILCEPSVKSLCEGLEKAIFQLKSGALPPPENIHNIVKTFYTWRNVAERTEKVYDRVAGEAVLPMDKRLDRLISHCGPVTGYIFALLAVFNFLFLIFLRWLFFPSKLSFNY", "length": 456, "header": "tr|E1B7B9-1|E1B7B9_BOVIN Isoform 1 of Phosphatidylinositol N-acetylglucosaminyltransferase subunit A OS=Bos taurus OX=9913 GN=PIGA PE=3 SV=2 CANONICAL=E1B7B9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZ81-1", "url": "https://www.uniprot.org/uniprotkb/E1B7B9/entry#A0A3Q1LZ81-1", "sequence": { "sequence": "MGLAGTDLLSGIIPELCQKYPDLKFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLIILCEPSVKSLCEGLEKAIFQLKSGALPPPENIHNIVKTFYTWRNVAERTEKVYDRVAGEAVLPMDKRLDRLISHCGPVTGYIFALLAVFNFLFLIFLRWVTPDSLIDVAIDATGPKGAWTHRYPYSKRGAEHTVLSKTR", "length": 250, "header": "tr|A0A3Q1LZ81-1|E1B7B9_BOVIN Computationally mapped isoform of Phosphatidylinositol N-acetylglucosaminyltransferase subunit A OS=Bos taurus OX=9913 GN=PIGA PE=3 SV=3 CANONICAL=E1B7B9-1" }, "locus": { "chromosome": "X", "start_pos": 128173453, "end_pos": 128161970, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086076.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086076.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066131.3", "url": "https://www.ensembl.org/id/ENSBTAP00000066131.3" } ] } }, { "isoform_ac": "A0AAA9U112-1", "url": "https://www.uniprot.org/uniprotkb/E1B7B9/entry#A0AAA9U112-1", "sequence": { "sequence": "MAYRGRGGRGQPSSASLSRVIPGSLHTFRTCAHNICMVSDFFYPNMGGVESHIYQLSQCLIERGHKVIIVTHAYGNRKGIRYLTNGLKVYYLPLKVMYNQSTATTLFHSLPLLRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLIILCEPSVKSLCEGLEKAIFQLKSGALPPPENIHNIVKTFYTWRNVAERTEKVYDRVAGEAVLPMDKRLDRLISHCGPVTGYIFALLAVFNFLFLIFLRWVTPDSLIDVAIDATGPKGAWTHRYPYSKRGAEHTVLSKTR", "length": 315, "header": "tr|A0AAA9U112-1|E1B7B9_BOVIN Computationally mapped isoform of Phosphatidylinositol N-acetylglucosaminyltransferase subunit A OS=Bos taurus OX=9913 GN=PIGA PE=3 SV=1 CANONICAL=E1B7B9-1" }, "locus": { "chromosome": "X", "start_pos": 128173453, "end_pos": 128163980, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092734.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092734.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102840.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102840.1" } ] } }, { "isoform_ac": "E1B7B9-1", "url": "https://www.uniprot.org/uniprotkb/E1B7B9/entry#E1B7B9-1", "sequence": { "sequence": "MAYRGRGGRGQPSSASLSRVIPGSLHTFRTCAHNICMVSDFFYPNMGGVESHIYQLSQCLIERGHKVIIVTHAYGNRKGIRYLTNGLKVYYLPLKVMYNQSTATTLFHSLPLLRYIFVRERVTIIHSHSSFSAMAHDALFHAKTMGLQTVFTDHSLFGFADVSSVLTNKLLTVSLCDTNHIICVSYTSKENTVLRAALNPEIVSVIPNAVDPTDFTPDPFRRHDSIITIVVVSRLVYRKGTDLLSGIIPELCQKYPDLKFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLIILCEPSVKSLCEGLEKAIFQLKSGALPPPENIHNIVKTFYTWRNVAERTEKVYDRVAGEAVLPMDKRLDRLISHCGPVTGYIFALLAVFNFLFLIFLRWLFFPSKLSFNY", "length": 456, "header": "tr|E1B7B9-1|E1B7B9_BOVIN Isoform 1 of Phosphatidylinositol N-acetylglucosaminyltransferase subunit A OS=Bos taurus OX=9913 GN=PIGA PE=3 SV=2 CANONICAL=E1B7B9-1" }, "locus": { "chromosome": "X", "start_pos": 128175132, "end_pos": 128163980, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010060.4", "url": "https://www.ensembl.org/id/ENSBTAT00000010060.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010060.3", "url": "https://www.ensembl.org/id/ENSBTAP00000010060.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:100139601", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100139601", "resource": "KEGG Pathway" }, { "id": "R-BTA-162710", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-162710", "resource": "Reactome", "description": "Synthesis of glycosylphosphatidylinositol (GPI)" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex", "id": "GO:0000506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000506", "evidence": [ { "database": "UniProtKB", "id": "E1B7B9", "url": "https://www.uniprot.org/uniprotkb/E1B7B9" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1B7B9", "url": "https://www.uniprot.org/uniprotkb/E1B7B9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "GPI anchor biosynthetic process", "id": "GO:0006506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006506", "evidence": [ { "database": "UniProtKB", "id": "E1B7B9", "url": "https://www.uniprot.org/uniprotkb/E1B7B9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphatidylinositol N-acetylglucosaminyltransferase activity", "id": "GO:0017176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017176", "evidence": [ { "database": "UniProtKB", "id": "E1B7B9", "url": "https://www.uniprot.org/uniprotkb/E1B7B9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "14789", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + UDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1B7B9-1" ], "evidence": [ { "id": "14789", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14789" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "E1B7B9", "gene_name": "PIGA", "activity": [ { "ec_number": "2.4.1.198", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + UDP + H(+).", "evidence": [ { "id": "E1B7B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7B9" } ] }, { "ec_number": "2.4.1.198", "activity": "", "evidence": [ { "id": "E1B7B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7B9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7B9" }, { "id": "PF00534", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00534" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glycosyl transferase family 1", "eco_id": "ECO_0000259", "start_pos": 228, "end_pos": 364, "start_aa": "Thr", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B7B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7B9" }, { "id": "PF08288", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08288" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PIGA GPI anchor biosynthesis", "eco_id": "ECO_0000259", "start_pos": 72, "end_pos": 161, "start_aa": "His", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.4.1.198", "ec_name": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + UDP + H(+).", "evidence": [ { "id": "2.4.1.198", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.198" }, { "id": "2.4.1.198", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.1.198" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 308, "end_pos": 310 }, { "start_pos": 99, "end_pos": 101 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B9M6-1", "uniprot_ac": "E1B9M6", "uniprot_id": "E1B9M6_BOVIN", "mass": { "chemical_mass": 57554.0, "monoisotopic_mass": 57554.0 }, "refseq": { "ac": "NP_001179917", "name": "dual specificity protein kinase CLK4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179917" }, "gene_names": [ { "name": "CLK4", "type": "recommended", "evidence": [ { "id": "E1B9M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9M6" } ] }, { "name": "CLK4", "type": "synonym", "evidence": [ { "id": "NP_001179917", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179917" } ] } ], "protein_names": [ { "name": "dual-specificity kinase", "type": "recommended", "evidence": [ { "id": "E1B9M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9M6/entry#names_and_taxonomy" } ] }, { "name": "2.7.12.1", "type": "synonym", "evidence": [ { "id": "E1B9M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9M6/entry#names_and_taxonomy" } ] }, { "name": "dual specificity protein kinase CLK4", "type": "synonym", "evidence": [ { "id": "NP_001179917", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179917" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9M6", "url": "https://www.uniprot.org/uniprotkb/E1B9M6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLK4", "url": "https://www.uniprot.org/uniprotkb/E1B9M6", "locus": { "chromosome": "7", "start_pos": 39743245, "end_pos": 39761816, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019414", "url": "https://www.ensembl.org/id/ENSBTAG00000019414" } ] } } ], "crossref": [ { "id": "E1B9M6", "url": "https://alphafold.ebi.ac.uk/entry/E1B9M6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019414", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019414", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14213", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14213", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "529633", "url": "https://www.ncbi.nlm.nih.gov/gene/529633", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051175", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051175", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529633", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529633", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NFRCVQM", "url": "https://omabrowser.org/oma/group/NFRCVQM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M291", "url": "https://www.orthodb.org/?gene=A0A3Q1M291", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B9M6", "url": "https://www.orthodb.org/?gene=E1B9M6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45646", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45646", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45646:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45646:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179917", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M291", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M291", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M291-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M291-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9M6", "url": "https://www.uniprot.org/uniprotkb/E1B9M6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9M6-1", "url": "https://www.uniprot.org/uniprotkb/E1B9M6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRHSKRTHCPDWDSRESWGHESYSGSHKRKRRSHSSTQENRYCKPHHQFKESDCHYLEARSLNERDYRDRRYIDEYRNDYCERYVPRHYHRDVESSFRIHCSKSSVRSRRSSPKRKRNRHCSSHQSHSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHDMDGIHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPTHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPVKRITLDEALQHPFFDLLKKK", "length": 481, "header": "tr|E1B9M6-1|E1B9M6_BOVIN Isoform 1 of dual-specificity kinase OS=Bos taurus OX=9913 GN=CLK4 PE=3 SV=1 CANONICAL=E1B9M6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M291-1", "url": "https://www.uniprot.org/uniprotkb/E1B9M6/entry#A0A3Q1M291-1", "sequence": { "sequence": "MCIPLEASHSVEEDSHPSHYLEARSLNERDYRDRRYIDEYRNDYCERYVPRHYHRDVESSFRIHCSKSSVRSRRSSPKRKRNRHCSSHQSHSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHDMDGIHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPTHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPVKRITLDEALQHPFFDLLKKK", "length": 445, "header": "tr|A0A3Q1M291-1|E1B9M6_BOVIN Computationally mapped isoform of dual-specificity kinase OS=Bos taurus OX=9913 GN=CLK4 PE=3 SV=2 CANONICAL=E1B9M6-1" }, "locus": { "chromosome": "7", "start_pos": 39758056, "end_pos": 39743776, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072853.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072853.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063888.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063888.2" } ] } }, { "isoform_ac": "E1B9M6-1", "url": "https://www.uniprot.org/uniprotkb/E1B9M6/entry#E1B9M6-1", "sequence": { "sequence": "MRHSKRTHCPDWDSRESWGHESYSGSHKRKRRSHSSTQENRYCKPHHQFKESDCHYLEARSLNERDYRDRRYIDEYRNDYCERYVPRHYHRDVESSFRIHCSKSSVRSRRSSPKRKRNRHCSSHQSHSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHDMDGIHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPTHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPVKRITLDEALQHPFFDLLKKK", "length": 481, "header": "tr|E1B9M6-1|E1B9M6_BOVIN Isoform 1 of dual-specificity kinase OS=Bos taurus OX=9913 GN=CLK4 PE=3 SV=1 CANONICAL=E1B9M6-1" }, "locus": { "chromosome": "7", "start_pos": 39761816, "end_pos": 39743776, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025863.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025863.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025863.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025863.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:529633", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529633", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VVL0-1", "protein_name": "dual-specificity kinase", "gene_name": "CLK4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRHSKRTHCPDWDSRESWGHESYSGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYIDEYRNDYCERYVPRHYHRDIESSYRIHCSKSSVRSRRSSLKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPTHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPVKRITLDEALQHPFFDLLKKK", "length": 481 }, "evidence": [ { "id": "E1B9M6", "url": "https://omabrowser.org/oma/group/E1B9M6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I5ZNT1-1", "protein_name": "dual-specificity kinase", "gene_name": "Clk4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRHSKRTHCPDWDSRESWGHESYSGSHKRKRRSHSSTQENRHCKPHHQFKDTDCHYLEARCLNERDYRDRRYIDEYRNDYCEGYVPRHYHRDIESTYRIHCSKSSVRSRRSSPKRKRNRHCASHQSHSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGLHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPAHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTKRITLDEALQHPFFDLLKGK", "length": 481 }, "evidence": [ { "id": "E1B9M6", "url": "https://omabrowser.org/oma/group/E1B9M6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A9J7K0H2-1", "protein_name": "dual-specificity kinase", "gene_name": "Clk4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKATVEATSGRGDRTVVHKRTGIVNHIISLKILIDVPLGLFTRLLSKLASWGYFKKHHYLEARCLNGRDYRDRRYIDEYRNDYCEGYVPRHYHRDIESSYRIHCSKSSVRSRRSSPKRKRNRHCASHQSHSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGLHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPAHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPAKRITLDEALQHPFFDLLKRK", "length": 484 }, "evidence": [ { "id": "E1B9M6", "url": "https://omabrowser.org/oma/group/E1B9M6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E1C4D8-1", "protein_name": "dual-specificity kinase", "gene_name": "CLK4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MYLFEHRIPAYNVQQRKLEQMRHSKQSHCPEWDDRRSWDQRKHSSSRKRRKRSHSSGQESKHYKPNHVSESHYLDDRTINERDHHDRRYVEEYRNDFCEVYDHRHYHRDYEKSHHHHYSKSSGRSRKSSHKRKHKRHHCSSHQSHSKSHRRKRSRSVEDDEEGHLICESGDVLRARYEIVATLGEGAFGKVVECIDHDMRGMHVAVKIVKNVGRYREAARSEIQVLEHLNTMDPSSTFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFHINDIRNMAYQICQSINFLHHNKLTHTDLKPENILFVESDYIVKYNAKMKRDERTLKNTDIKVVDFGSATFDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPLPAHMIKKSRKHYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMHCQDTDHQSLFDLVRRMLEYDPAKRITLDEALQHPFFDPLKK", "length": 497 }, "evidence": [ { "id": "E1B9M6", "url": "https://omabrowser.org/oma/group/E1B9M6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O35493-1", "protein_name": "Dual specificity protein kinase CLK4", "gene_name": "Clk4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRHSKRTHCPDWDSRESWGHESYSGSHKRKRRSHSSTQENRHCKPHHQFKDSDCHYLEARCLNERDYRDRRYIDEYRNDYCEGYVPRHYHRDVESTYRIHCSKSSVRSRRSSPKRKRNRPCASHQSHSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGLHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPAHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPARRITLDEALQHPFFDLLKRK", "length": 481 }, "evidence": [ { "id": "E1B9M6", "url": "https://omabrowser.org/oma/group/E1B9M6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HAZ1-1", "protein_name": "Dual specificity protein kinase CLK4", "gene_name": "CLK4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK", "length": 481 }, "evidence": [ { "id": "E1B9M6", "url": "https://omabrowser.org/oma/group/E1B9M6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "E1B9M6", "url": "https://www.uniprot.org/uniprotkb/E1B9M6" } ], "pmid": "" }, { "name": "protein tyrosine kinase activity", "id": "GO:0004713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004713", "evidence": [ { "database": "UniProtKB", "id": "E1B9M6", "url": "https://www.uniprot.org/uniprotkb/E1B9M6" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1B9M6", "url": "https://www.uniprot.org/uniprotkb/E1B9M6" } ], "pmid": "" }, { "name": "protein serine/threonine/tyrosine kinase activity", "id": "GO:0004712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004712", "evidence": [ { "database": "UniProtKB", "id": "E1B9M6", "url": "https://www.uniprot.org/uniprotkb/E1B9M6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B9M6", "url": "https://www.uniprot.org/uniprotkb/E1B9M6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of RNA splicing", "id": "GO:0043484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043484", "evidence": [ { "database": "UniProtKB", "id": "E1B9M6", "url": "https://www.uniprot.org/uniprotkb/E1B9M6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 212, "end_pos": 214, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9M6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 481, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9M6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9M6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9M6" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 159, "end_pos": 475, "start_aa": "Tyr", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.12.1", "ec_name": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.12.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1" }, { "id": "2.7.12.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.12.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 212, "end_pos": 214 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B754-1", "uniprot_ac": "E1B754", "uniprot_id": "E1B754_BOVIN", "mass": { "chemical_mass": 197539.0, "monoisotopic_mass": 197539.0 }, "refseq": { "ac": "XP_005204937", "name": "microtubule-associated serine/threonine-protein kinase 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204937" }, "gene_names": [ { "name": "MAST2", "type": "recommended", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "name": "MAST2", "type": "synonym", "evidence": [ { "id": "XP_005204937", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204937" } ] } ], "protein_names": [ { "name": "non-specific serine/threonine protein kinase", "type": "recommended", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754/entry#names_and_taxonomy" } ] }, { "name": "microtubule-associated serine/threonine-protein kinase 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005204937", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204937" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B754", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAST2", "url": "https://www.uniprot.org/uniprotkb/E1B754", "locus": { "chromosome": "3", "start_pos": 100070398, "end_pos": 100278239, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020444", "url": "https://www.ensembl.org/id/ENSBTAG00000020444" } ] } } ], "crossref": [ { "id": "ENSBTAG00000020444", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020444", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05609", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05609", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd23074", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23074", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535643", "url": "https://www.ncbi.nlm.nih.gov/gene/535643", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": 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"https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037711", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037711", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041489", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041489", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535643", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535643", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1B754", "url": "https://www.orthodb.org/?gene=E1B754", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24356", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24356", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24356:SF136", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24356:SF136", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08926", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08926", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17820", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17820", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005204937", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204937", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M514", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M514", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M514-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M514-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIM9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIM9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B754", "url": "https://www.uniprot.org/uniprotkb/E1B754", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B754-1", "url": "https://www.uniprot.org/uniprotkb/E1B754-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRSRCRDRPQPPPPPLPQAAGREDGAQRAAELPQPQPLPPRRRAPPGRQRLEERTGPVGPEVREQDVVTGRSPLLFRKLSNPDIFSSTGKAKLQRQLSQDDCKLRRGSLASSLSGKQLLPLSGSAHSSVGQVTWQSSGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTSSTSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVPARSHGHRADRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTDSVPDEEGRQSPALRPRSRSLSPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDNVLPLADGTLSFIHHQVIEMARDCLDKSRSGLITSHYFYELQENLEKLLQDAHERSESSEVAFVMQLVKKLMIVIARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSYDSPDTPETDDSVEGRGASLTSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFETKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDDALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHVDSEDEEEVSEDGCLEIRQFSSCSPRFSKVYSSMERLSLLEERRTPPPTKRSLSEEKEDRTDGLAGLRGRERSWVIGSPEILRKRLSVSESSHTESDSSPPLTVRRHCSGLLDVPRFPESTEEAVGAPRRQQQEGAWLLTPSGEGASGPALERPAERRLKLNEEPAGQSSAPSPAMETRGGRGTPQLAEGATARAISDLAVRRARHRLLSGDSIEKRTARPINKVIKSASATALSLLIPAEHHSCSPLASPMSPHSQSSNPSSRDSSPSRDFLPALSSSRPPIVIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVSISTTPLENTSIKVGPARKGSYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPTQGYRVTPEAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLHGLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPAASPQRSPSPLSGHGAQAFPTKLHLSPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKQSLDLPHPELKKELPPREVSSLEVVGTRSVLSGKGALPGKGVLQAAPSRALGTLRQDRAERRESLQKQEAIREVDSSEDDTDEGPENSQGVQEPSLVPHREGGQDPPLRGAGEGEEEDAFLPRDPRGQGPVVTGLLTGVTLGSPRMEGPGVPQKKLGILQAFEEGSSSSSSAPNLGKAGPTDPIPAEGCWKAQHLHTQALTALCPSSSGRIPASCSTASTPGELGPWSWKFLFKGPDRAYPTGKAAMEDGPASSQDLETTTPGHPANLSPRQEGKSWPPSAPGLAHPPCEVPSQSWLWESECAQREKEEPALGITKVPDASGDRRQDVPCKSCPFTPEPGPSLLQKGQDPGGPQEHQDLALLPDELLKQT", "length": 1810, "header": "tr|E1B754-1|E1B754_BOVIN Isoform 1 of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=MAST2 PE=3 SV=4 CANONICAL=E1B754-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M514-1", "url": "https://www.uniprot.org/uniprotkb/E1B754/entry#A0A3Q1M514-1", "sequence": { "sequence": "MMKRRRERLGAPCLRIHCRTSNRKSLIVTSSTSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVPARSHGHRADRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTDSVPDEEGRQSPALRPRSRSLSPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDNVLPLADGTLSFIHHQVIEMARDCLDKSRSGLITSHYFYELQENLEKLLQDAHERSESSEVAFVMQLVKKLMIVIARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSYDSPDTPETDDSVEGRGASLTSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFETKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDDALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHVDSEDEEEVSEDGCLEIRQFSSCSPRFSKVYSSMERLSLLEERRTPPPTKRSLSEEKEDRTDGLAGLRGRERSWVIGSPEILRKRLSVSESSHTESDSSPPLTVRRHCSGLLDVPRFPESTEEAVGAPRRQQQEGAWLLTPSGEGASGPALERPAERRLKLNEEPAGQSSAPSPAMETRGGRGTPQLAEGATARAISDLAVRRARHRLLSGDSIEKRTARPINKVIKSASATALSLLIPAEHHSCSPLASPMSPHSQSSNPSSRDSSPSRDFLPALSSSRPPIVIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVSISTTPLENTSIKVGPARKGSYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPTQGYRVTPEAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLHGLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPAASPQRSPSPLSGHGAQAFPTKLHLSPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKQSLDLPHPELKKELPPREVSSLEVVGTRSVLSGKGALPGKGVLQAAPSRALGTLRQDRAERRESLQKQEAIREVDSSEDDTDEGPENSQGVQEPSLVPHREGGQDPPLRGAGEGEEEDAFLPRDPRGQGPVVTGLLTGVTLGSPRMEGPGVPQKKLGILQAFEEGSSSSSSAPNLGKAGPTDPIPAEGCWKAQHLHTQALTALCPSSSGRIPASCSTASTPGELGPWSWKFLFKGPDRAYPTGKAAMEDGPASSQDLETTTPGHPANLSPRQEGKSWPPSAPGLAHPPCEVPSQSWLWESECAQREKEEPALGITKVPDASGDRRQDVPCKSCPFTPEPGPSLLQKGQDPGGPQEHQDLALLPDELLKQT", "length": 1653, "header": "tr|A0A3Q1M514-1|E1B754_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=MAST2 PE=3 SV=2 CANONICAL=E1B754-1" }, "locus": { "chromosome": "3", "start_pos": 100165902, "end_pos": 100071344, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072561.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072561.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065342.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065342.2" } ] } }, { "isoform_ac": "A0A3Q1MIM9-1", "url": "https://www.uniprot.org/uniprotkb/E1B754/entry#A0A3Q1MIM9-1", "sequence": { "sequence": "MKRSRCRDRPQPPPPPLPQAAGREDGAQRAAELPQPQPLPPRRRAPPGRQRLEERTGPVGPEVREQDVVTGRSPLLFRKLSNPDIFSSTGKAKLQRQLSQDDCKLRRGSLASSLSGKQLLPLSGSAHSSVGQVTWQSSGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTSSTSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVPARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTDSVPDEEGRQSPALRPRSRSLSPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDNVLPLADGTLSFIHHQVIEMARDCLDKSRSGLITSHYFYELQENLEKLLQDAHERSESSEVAFVMQLVKKLMIVIARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSYDSPDTPETDDSVEGRGASLTSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFETKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDDALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHVDSEDEEEVSEDGCLEIRQFSSCSPRFSKVYSSMERLSLLEERRTPPPTKRSLSEEKEDRTDGLAGLRGRERSWVIGSPEILRKRLSVSESSHTESDSSPPLTVRRHCSGLLDVPRFPESTEEAVGAPRRQQQEGAWLLTPSGEGASGPALERPAERRLKLNEEPAGQSSAPSPAMETRGGRGTPQLAEGATARAISDLAVRRARHRLLSGDSIEKRTARPINKVIKSASATALSLLIPAEHHSCSPLASPMSPHSQSSNPSSRDSSPSRDFLPALSSSRPPIVIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVSISTTPLENTSIKVGPARKGSYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPTQGYRVTPEAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLHGLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPAASPQRSPSPLSGHGAQAFPTKLHLSPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKQSLDLPHPELKKELPPREVSSLEVVGTRSVLSGKGALPGKGVLQAAPSRALGTLRQDRAERRESLQKQEAIREVDSSEDDTDEGPENSQGVQEPSLVPHREGGQDPPLRGAGEGEEEDAFLPRDPRGQGPVVTGLLTGVTLGSPRMEGPGVPQKKLGILQAFEEGSSSSSSAPNLGKAGPTDPIPAEGCWKAQHLHTQALTALCPSSSGRIPASCSTASTPGELGPWSWKFLFKGPDRAYPTGKAAMEDGPASSQDLETTTPGHPANLSPRQEGKSWPPSAPGLAHPPCEVPSQSWLWESECAQREKEEPALGITKVPDASGDRRQDVPCKSCPFTPEPGPSLLQKGQDPGGPQEHQDLALLPDELLKQT", "length": 1803, "header": "tr|A0A3Q1MIM9-1|E1B754_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=MAST2 PE=3 SV=2 CANONICAL=E1B754-1" }, "locus": { "chromosome": "3", "start_pos": 100278040, "end_pos": 100071344, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087105.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087105.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069029.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069029.2" } ] } }, { "isoform_ac": "E1B754-1", "url": "https://www.uniprot.org/uniprotkb/E1B754/entry#E1B754-1", "sequence": { "sequence": "MKRSRCRDRPQPPPPPLPQAAGREDGAQRAAELPQPQPLPPRRRAPPGRQRLEERTGPVGPEVREQDVVTGRSPLLFRKLSNPDIFSSTGKAKLQRQLSQDDCKLRRGSLASSLSGKQLLPLSGSAHSSVGQVTWQSSGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTSSTSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVPARSHGHRADRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTDSVPDEEGRQSPALRPRSRSLSPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDNVLPLADGTLSFIHHQVIEMARDCLDKSRSGLITSHYFYELQENLEKLLQDAHERSESSEVAFVMQLVKKLMIVIARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSYDSPDTPETDDSVEGRGASLTSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFETKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDDALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHVDSEDEEEVSEDGCLEIRQFSSCSPRFSKVYSSMERLSLLEERRTPPPTKRSLSEEKEDRTDGLAGLRGRERSWVIGSPEILRKRLSVSESSHTESDSSPPLTVRRHCSGLLDVPRFPESTEEAVGAPRRQQQEGAWLLTPSGEGASGPALERPAERRLKLNEEPAGQSSAPSPAMETRGGRGTPQLAEGATARAISDLAVRRARHRLLSGDSIEKRTARPINKVIKSASATALSLLIPAEHHSCSPLASPMSPHSQSSNPSSRDSSPSRDFLPALSSSRPPIVIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVSISTTPLENTSIKVGPARKGSYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPTQGYRVTPEAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLHGLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPAASPQRSPSPLSGHGAQAFPTKLHLSPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKQSLDLPHPELKKELPPREVSSLEVVGTRSVLSGKGALPGKGVLQAAPSRALGTLRQDRAERRESLQKQEAIREVDSSEDDTDEGPENSQGVQEPSLVPHREGGQDPPLRGAGEGEEEDAFLPRDPRGQGPVVTGLLTGVTLGSPRMEGPGVPQKKLGILQAFEEGSSSSSSAPNLGKAGPTDPIPAEGCWKAQHLHTQALTALCPSSSGRIPASCSTASTPGELGPWSWKFLFKGPDRAYPTGKAAMEDGPASSQDLETTTPGHPANLSPRQEGKSWPPSAPGLAHPPCEVPSQSWLWESECAQREKEEPALGITKVPDASGDRRQDVPCKSCPFTPEPGPSLLQKGQDPGGPQEHQDLALLPDELLKQT", "length": 1810, "header": "tr|E1B754-1|E1B754_BOVIN Isoform 1 of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=MAST2 PE=3 SV=4 CANONICAL=E1B754-1" }, "locus": { "chromosome": "3", "start_pos": 100278040, "end_pos": 100071344, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033290.6", "url": "https://www.ensembl.org/id/ENSBTAT00000033290.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033207.6", "url": "https://www.ensembl.org/id/ENSBTAP00000033207.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1621, "start_aa": "Thr", "end_pos": 1621, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1621", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1660, "start_aa": "Thr", "end_pos": 1660, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1660", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:535643", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535643", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "E1B754", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "E1B754", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1B754", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "E1B754", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ], "pmid": "" }, { "name": "phosphatase binding", "id": "GO:0019902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019902", "evidence": [ { "database": "UniProtKB", "id": "E1B754", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B754", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ], "pmid": "" }, { "name": "microtubule cytoskeleton", "id": "GO:0015630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "evidence": [ { "database": "UniProtKB", "id": "E1B754", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "developmental process", "id": "GO:0032502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032502", "evidence": [ { "database": "UniProtKB", "id": "E1B754", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "E1B754", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ], "pmid": "" }, { "name": "cytoskeleton organization", "id": "GO:0007010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "evidence": [ { "database": "UniProtKB", "id": "E1B754", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1207, "end_pos": 1209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1266, "end_pos": 1268, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1307, "end_pos": 1309, "annotation": "n_glycosylation_sequon" }, { "start_pos": 149, "end_pos": 151, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1707, "end_pos": 1709, "annotation": "n_glycosylation_sequon" }, { "start_pos": 214, "end_pos": 216, "annotation": 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H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": 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"https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { "uniprot_ac": "A0A3Q1MI36", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": 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"ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": 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1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": 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} ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": 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"uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B9N8-1", "uniprot_ac": "E1B9N8", "uniprot_id": "E1B9N8_BOVIN", "mass": { "chemical_mass": 603423.0, "monoisotopic_mass": 603423.0 }, "refseq": { "ac": "XP_024848229", "name": "histone-lysine N-methyltransferase 2D isoform X10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848229" }, "gene_names": [ { "name": "KMT2D", "type": "recommended", "evidence": [ { "id": "E1B9N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N8" } ] }, { "name": "KMT2D", "type": "synonym", "evidence": [ { "id": "XP_024848229", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848229" } ] } ], "protein_names": [ { "name": "Histone-lysine N-methyltransferase 2D", "type": "recommended", "evidence": [ { "id": "E1B9N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N8/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.364", "type": "synonym", "evidence": [ { "id": "E1B9N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N8/entry#names_and_taxonomy" } ] }, { "name": "ALL1-related protein", "type": "synonym", "evidence": [ { "id": "E1B9N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N8/entry#names_and_taxonomy" } ] }, { "name": "Myeloid/lymphoid or mixed-lineage leukemia protein 2", "type": "synonym", "evidence": [ { "id": "E1B9N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N8/entry#names_and_taxonomy" } ] }, { "name": "histone-lysine N-methyltransferase 2D isoform X10", "type": "synonym", "evidence": [ { "id": "XP_024848229", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848229" } ] } ], "function": [ { "annotation": "Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LM54", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM54#function" }, { "database": "UniProtKB", "id": "ARBA00058707", "url": "https://www.uniprot.org/uniprotkb/ARBA00058707#function" }, { "database": "UniProtKB", "id": "E1B9N8", "url": "https://www.uniprot.org/uniprotkb/E1B9N8#function" }, { "database": "UniProtKB", "id": "ARBA00056994", "url": "https://www.uniprot.org/uniprotkb/ARBA00056994#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9N8", "url": "https://www.uniprot.org/uniprotkb/E1B9N8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KMT2D", "url": "https://www.uniprot.org/uniprotkb/E1B9N8", "locus": { "chromosome": "5", "start_pos": 30797551, "end_pos": 30760002, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014429", "url": "https://www.ensembl.org/id/ENSBTAG00000014429" } ] } } ], "crossref": [ { "id": "ENSBTAG00000014429", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014429", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15509", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15509", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15513", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15513", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15597", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15597", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15601", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15601", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15695", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15695", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15698", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15698", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19209", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19209", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22027", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22027", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506805", "url": "https://www.ncbi.nlm.nih.gov/gene/506805", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003616", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003616", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003888", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003888", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003889", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034732", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034732", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037890", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037890", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041964", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041964", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046999", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046999", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LM54", "url": "https://www.orthodb.org/?gene=A0A3Q1LM54", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B9N8", "url": "https://www.orthodb.org/?gene=E1B9N8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45888", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45888", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45888:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45888:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00856", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00856", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05964", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05964", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05965", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05965", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13771", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13771", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13832", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13832", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024848229", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848229", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "60264", "url": "https://www.rhea-db.org/rhea/60264", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LM54", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM54", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LM54-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM54-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9N8", "url": "https://www.uniprot.org/uniprotkb/E1B9N8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9N8-1", "url": "https://www.uniprot.org/uniprotkb/E1B9N8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSPKPPGEDKDSEPAADGPAASEESGATEPDLPKPHVGEVSVPSSGGPRLQEPPQDCSGGPVRRCALCNCGEPSLHGQRELRRFELPFDWPRCPVVSPGGNPGPSEGALPSEDLSQIGFPEGLTPAHLGEPGGSCWAHHWCAAWSAGVWGQEGPELCGVDKAIFSGISQRCSHCTRLGASIPCRSPGCSRLYHFPCATASGSFLSMKTLQLLCPEHSEGATHLEEARCAVCEGPGELCDLFFCTSCGHHYHGACLDTALTARKRAGWQCPECKVCQACRKPGNDSKMLVCETCDKGYHTFCLKPPMEELPAHSWKCKACRVCRACGAGSAELNPNSEWFENYSLCHRCHKAPGGQPVSSLAEQHPPVCSRFSPLEPGATPTDEPNSLYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGREGAQLEPQLEAPLNEEMPLLPPPEESPLSPPPEDSPTSPPPEASRLSPPPEDSPLSPPPEESPLSPPPESPPFSSPEDSPPHPPLDTPLPPPPEASPLSPPLEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASCLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEDLPMSPPPEVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDPPASPPPEDLLVSLPLEESPLLPLPEELRLCPRPEEPHLSPQPEKPRLSPAPQEPRLSPASQEPRLSPAPQEPCLSPAPEEPRLSPAPQQPCLSPAPEEPRLSPAPQQPHLSPVPQQPHLSPAPEEPRLSPASKELRLSPAPQEPCLSPAPQELHLSPVPEEPHLSLASEEPRLSPQPEEPCLSPRPEEPRLSPRPEEPRLSPRPEEPRLTPRPEEPHLSPRPEEPIEEPSLCLASEELPLLLPPREPPLSPVLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITTVAPPALSPLGELEYPFDAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPMGPASPILMEPLPPRCSPLLQHSLPPSNSPPSQCSPALPLLVPSPLSPMDKAVEVSEEAEPQKMETEKAPEPECPALEPSPTSPLPSPLGNLSCPAPSPAPALDDFCGLGEDTAPLDGTDTPGSQPEAGQTPGSLASELKGSPVLLDSEELAPVTPMEVYGPECKQAGQGSPCEEQEEPRAPVAPTPPILIKSDIVNEISNLSQGDASASFPGSEPLLGSPDPEGGGSLSMELGVSTDVSPARDEGSLRLCTDSLPETDDSLLCDAGTAIGGGKAEGDKGRRRSSPARSRIKQGRSSSFPGRRRPRGGAHGGRGRGRARLKSTTSSIETLVVADIDSSPSKEEEDDDDDTMQNTVVLFSNTDKFVLMQDMCVVCGSFGRGAEGHLLACSQCSQCYHPYCVNSKITKVMLLKGWRCVECIVCEVCGQASDPSRLLLCDDCDISYHTYCLDPPLLTVPKGGWKCKWCVSCMQCGAASPGFHCEWQNSYTHCGPCASLVTCPICHAPYVEEDLLIQCRHCERWMHAGCESLFTEDDVEQAADEGFDCVSCQPYVVKPAAPVAPPELVPMKVKEPEPQYFRFEGVWLTETGMAVLRNLTMSPLHKRRQRRGRPGLPGEAGLEGAEPSEVLGPDDKKDGDLDTDELLKAEGSVEHMECEIKLEGPVSPDGEPGKEETEESKKRKRKPYRPGIGGFMVRQRKSHTRVKKGPAAQAEVLSGDGQPDEGETVLPADLPAEGSVDQGLADGDEKKKQQRRGRKKNKLEDMFPAYLQEAFFGKELLDLSRKALFAVGVGRPSFGLGTPKAKGDGGSERKELPTSQKGDDGPDVADEESRGPEGKADTPGPEDGGIKASPVPSDPEKPGTPGEGMLSSDLDRIPTEELPKMESKDLQQLFKDVLGSEREQHLGCGTPGLDGSRTPLQRPFLQGGLPLGNLPSNSPMDSYPGLCQSPFLDSRERGGFFSPEPGEPDSPWTGSGGTTPSTPTTPTTEGEGDGLSYNQRSLQRWEKDEELGQLSTISPVLYANINFPSLKQDYPDWSSRCKQIMKLWRKVPAADKAPYLQKAKDNRAAHRINKVQKQAESQINKQTKVGDMARKTDRPALHLRIPPQPGALGSPPPAAAPTIFIGSPTPPAGLSTSADGFLKPPAGTVPGPDSPGELFLKLPPQVPAQVPSQDPFGLASAYALEPRFPTAPPTYPPYPSPTGAPAPPPTLGASSRPGTGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGGGGSKAAEPLLSPLPFGESRKALEVKKEELGGSSPSYGPPNLGFVDSPSSGPHLGGLELKAPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHSDIFRPGPYPDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPSEVAFKAGPLAHTPLGAGGFPAALPSGPAGELHAKVPSVQPPNFARSPGTSAFVGAPSPMRFTFPQAVGEPPLKPPVPQPGLPPPHGINSHFGPGPTMGKPQSTNYAVAAGNFRPSGSPLGPSSGPAGEGYGPSPLRPPSVLPQPTPDGPLPCLPHGATQRAGITSPVEKREDPGAGTGSSLAAPELSGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQMQRNTLRQEKETAAAAGAVGPPGNWGAEPSSPAFEQLGRGQTPFAGTQDKSSLVGLPPSKLGGPILGPGAFPSDDRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQQLWQQQQQATAAASMRLTMSARFPSTPGPELGRQTLGSPLAGISNRLPGPGEPVPGPAGPAQFIELRHNVQKGLGPGGPPFPGQGPPQRPRFYPVTEDSHRLAPEGLRGLAVSGLPPQKPSAPPAPELNNSLHPTPHTKGPNLPTGLELVSRPPSSTELGRPPPLTLEAGKLPCEDPELDDDFDAHKALEDDEELAHLGLGVDVAKGDDELGTLENLETNDPHLDDLLNGDEFDLLAYTDPELDTGDKKDIFNEHLRLVESANEKAEREALLRGVEPGPFGPEERPPPAADASEPRLASGLPEVKPKVEEGGRHPSPCQFTITTPKAELAPVTTSLGLGVKPGQSVTGSRDTRMGTGPFSSSGHTAEKVPFGTTGGPPAHLLTPSPLSGPGGSSLLEKFELESGALTLPGGHASGDELDKMESSLVASELPLLIEDLLEHEKKELQKKQQLSAQLQPVQQQQPQQHSLLSTPGPGQAVSLPHEGSSPSLAGPQQQLALGLGGSRQPGLAQPLMPNQPPAHALQQRLAPSMAMVSNQGHMLSGQHGGQAGLVPQQNPQPVLAQKPMGTVPPSMCMKPQQLAMQQQLANSFFPDTDLDKFAAEDIIDPIAKAKMVALKGIKKVMAQGSIGVAPGMNRQQVSLLAQRLSGGPGSDLQNHVAAGSGQERGAGDSSQPRPNPPTFAQGVINEADQRQYEEWLFHTQQLLQMQLKVLEEQIGVHRKSRKALCAKQRTAKKAGREFPEADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGGQAAGLRLTPGGMALPGQPGGPFLNTTLAQQQQQQHSGGAGALAGPSGGFFPGNLALRGLGPDSRLLQERQLQLQQQRMQLAQKLQQQQQQHLLGQVAIQQQQQQGPGVQANQALGPKPQGLLPPSSHQGLLVQQLSPQPPPGPQGMLGPAQVAVLQQQQPHPGALGPQGPHRQVLLTQPRVLSSPQMAQQGQGLMGHRLVTSQQQQQQQHQQQGSMAGLSHLQQGLMPHSGQPKVGAQPMAALQQQQLQQQQQQQQLQQHQQLQQQQQQLQQQQQQQQLQQQQQQLQQQQQQQQLQQQQQQQQLQQQQQQQQQLQQQQQQQQLQQQQQQQQLQQQQQQQQLQQQQQQQLQQQQQQQQLQQQQQQLQQQQQQQQLQQQQQIGLLSQSRALLSPQQQQQQQQMTLGPGMPAKPLQHFSSPGALGPTLILTGKEQSIVETALPSEASEGSSTHQGGPLPMGTVPESVAPEPGEVKPSLSGDSQLLLVQPQAQPQPNSLQLQPPLRLPGQQQPPVNLLHTAGAGSHGQPGSGSSEASSVPHLLAQSSVSLGEQPGSVTQNLLSSQQPLGLERPMQNNIGPQPAKPGSVPQSGQSLPGAGVMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLHALLMQRQLQQSQAARQAPPYQEPGTQPSPLQGLLGRQPQLGGFPGSQTGPLQELGAGLRPQGPPRLPAPQGALSTGPVLGPVHPTPPPSSPQEPKRPSSQLPSPSSQLPSEAQLPTTQPGTPKPQGPPLELPPGRVSPAAAQLADTFFGKGLGPWDPPDHLAEAQKLEQSSLVPGHLDQVNGQVVPEPPHLNIKQEPREEPCALGSQAVKREANGEPVGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGPEGLRAEINGHIDSKLAGLEQKPQGTPSTKEDTAARKPLTPKPKRVQKASDRLVSSRKKLRKEDGVRASEALLKQLKQELSLLPLTEPTITANFSLFAPFGSGCPISGQCQLRGAFGSGVLPTGPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAACARDTEGVLRDASEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPQLGSGRWEQDDRALSPVIPIIPRASIPVFPESKPYGVLDLETTRKLPAPTWEKGKGSEVSVMLTVSAAAAKNLNGMMVAVAELLSMKIPNSYEVLFPESPARAGIEPKKGEAEGPGGKEKSLGGKSPEAGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPAQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPAEPLVELPAEPSAEPPIPSPLPLASSPESTRPKPRARPPEEGEDSRPPRLKKWKGVRWKRLRLLLTIQKGGVRQEDEREVAEFMEQLGTALRPDKVPRDMRRCCFCHEEGDGATDGPARLLNLDLDLWVHLNCALWSTEVYETQGGALMNVEVALHRGLLTKCSLCQRTGATSSCNRMRCPNVYHFACAIRAKCMFFKDKTMLCPMHKIKGPCEQELSSFAVFRRVYIERDEVKQIASIIQRGERLHMFRVGGLVFHAIGQLLPHQMADFHSATALYPVGYEATRIYWSLRTNNRRCCYRCSIGENNGRPEFVIKVMEQGLEDMVFTDASPQAVWNRIIEPVAAMRKEADMLRLFPEYLKGEELFGLTVHAVLRIAESLPGVESCQNYLFRYGRHPLMELPLMINPTGCARSEPKILTHYKRPHTLNSTSMSKAYQSTFTGETNTPYSKQFVHSKSSQYRRLRTEWKNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQHKIPCHCGAWNCRKWMN", "length": 5622, "header": "tr|E1B9N8-1|E1B9N8_BOVIN Isoform 1 of Histone-lysine N-methyltransferase 2D OS=Bos taurus OX=9913 GN=KMT2D PE=4 SV=4 CANONICAL=E1B9N8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LM54-1", "url": "https://www.uniprot.org/uniprotkb/E1B9N8/entry#A0A3Q1LM54-1", "sequence": { "sequence": "MDSPKPPGEDKDSEPAADGPAASEESGATEPDLPKPHVGEVSVPSSGGPRLQEPPQDCSGGPVRRCALCNCGEPSLHGQRELRRFELPFDWPRCPVVSPGGNPGPSEGALPSEDLSQIGFPEGLTPAHLGEPGGSCWAHHWCAAWSAGVWGQEGPELCGVDKAIFSGISQRCSHCTRLGASIPCRSPGCSRLYHFPCATASGSFLSMKTLQLLCPEHSEGATHLEEARCAVCEGPGELCDLFFCTSCGHHYHGACLDTALTARKRAGWQCPECKVCQACRKPGNDSKMLVCETCDKGYHTFCLKPPMEELPAHSWKCKACRVCRACGAGSAELNPNSEWFENYSLCHRCHKAPGGQPVSSLAEQHPPVCSRFSPLEPGATPTDEPNSLYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGREGAQLEPQLEAPLNEEMPLLPPPEESPLSPPPEDSPTSPPPEASRLSPPPEDSPLSPPPEESPLSPPPESPPFSSPEDSPPHPPLDTPLPPPPEASPLSPPLEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASCLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEDLPMSPPPEVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDPPASPPPEDLLVSLPLEESPLLPLPEELRLCPRPEEPHLSPQPEKPRLSPAPQEPRLSPASQEPRLSPAPQEPCLSPAPEEPRLSPAPQQPCLSPAPEEPRLSPAPQQPHLSPVPQQPHLSPAPEEPRLSPASKELRLSPAPQEPCLSPAPQELHLSPVPEEPHLSLASEEPRLSPQPEEPCLSPRPEEPRLSPRPEEPRLSPRPEEPRLTPRPEEPHLSPRPEEPIEEPSLCLASEELPLLLPPREPPLSPVLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITTVAPPALSPLGELEYPFDAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPMGPASPILMEPLPPRCSPLLQHSLPPSNSPPSQCSPALPLLVPSPLSPMDKAVEVSEEAEPQKMETEKAPEPECPALEPSPTSPLPSPLGNLSCPAPSPAPALDDFCGLGEDTAPLDGTDTPGSQPEAGQTPGSLASELKGSPVLLDSEELAPVTPMEVYGPECKQAGQGSPCEEQEEPRAPVAPTPPILIKSDIVNEISNLSQGDASASFPGSEPLLGSPDPEGGGSLSMELGVSTDVSPARDEGSLRLCTDSLPETDDSLLCDAGTAIGGGKAEGDKGRRRSSPARSRIKQGRSSSFPGRRRPRGGAHGGRGRGRARLKSTTSSIETLVADIDSSPSKEEEDDDDDTMQNTVVLFSNTDKFVLMQDMCVVCGSFGRGAEGHLLACSQCSQCYHPYCVNSKITKVMLLKGWRCVECIVCEVCGQASDPSRLLLCDDCDISYHTYCLDPPLLTVPKGGWKCKWCVSCMQCGAASPGFHCEWQNSYTHCGPCASLVTCPICHAPYVEEDLLIQCRHCERWMHAGCESLFTEDDVEQAADEGFDCVSCQPYVVKPAAPVAPPELVPMKVKEPEPQYFRFEGVWLTETGMAVLRNLTMSPLHKRRQRRGRPGLPGEAGLEGAEPSEVLGPDDKKDGDLDTDELLKAEGSVEHMECEIKLEGPVSPDGEPGKEETEESKKRKRKPYRPGIGGFMVRQRKSHTRVKKGPAAQAEVLSGDGQPDEVLPADLPAEGSVDQGLADGDEKKKQQRRGRKKNKLEDMFPAYLQEAFFGKELLDLSRKALFAVGVGRPSFGLGTPKAKGDGGSERKELPTSQKGDDGPDVADEESRGPEGKADTPGPEDGGIKASPVPSDPEKPGTPGEGMLSSDLDRIPTEELPKMESKDLQQLFKDVLGSEREQHLGCGTPGLDGSRTPLQRPFLQGGLPLGNLPSNSPMDSYPGLCQSPFLDSRERGGFFSPEPGEPDSPWTGSGGTTPSTPTTPTTEGEGDGLSYNQRSLQRWEKDEELGQLSTISPVLYANINFPSLKQDYPDWSSRCKQIMKLWRKVPAADKAPYLQKAKDNRAAHRINKVQKQAESQINKQTKVGDMARKTDRPALHLRIPPQPGALGSPPPAAAPTIFIGSPTPPAGLSTSADGFLKPPAGTVPGPDSPGELFLKLPPQVPAQVPSQDPFGLASAYALEPRFPTAPPTYPPYPSPTGAPAPPPTLGASSRPGTGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGGGGSKAAEPLLSPLPFGESRKALEVKKEELGGSSPSYGPPNLGFVDSPSSGPHLGGLELKAPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHSDIFRPGPYPDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPSEVAFKAGPLAHTPLGAGGFPAALPSGPAGELHAKVPSVQPPNFARSPGTSAFVGAPSPMRFTFPQAVGEPPLKPPVPQPGLPPPHGINSHFGPGPTMGKPQSTNYAVAAGNFRPSGSPLGPSSGPAGEGYGPSPLRPPSVLPQPTPDGPLPCLPHGATQRAGITSPVEKREDPGAGTGSSLAAPELSGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQMQRNTLRQEKETAAAAGAVGPPGNWGAEPSSPAFEQLGRGQTPFAGTQDKSSLVGLPPSKLGGPILGPGAFPSDDRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQQLWQQQQQATAAASMRLTMSARFPSTPGPELGRQTLGSPLAGISNRLPGPGEPVPGPAGPAQFIELRHNVQKGLGPGGPPFPGQGPPQRPRFYPVTEDSHRLAPEGLRGLAVSGLPPQKPSAPPAPELNNSLHPTPHTKGPNLPTGLELVSRPPSSTELGRPPPLTLEAGKLPCEDPELDDDFDAHKALEDDEELAHLGLGVDVAKGDDELGTLENLETNDPHLDDLLNGDEFDLLAYTDPELDTGDKKDIFNEHLRLVESANEKAEREALLRGVEPGPFGPEERPPPAADASEPRLASGLPEVKPKVEEGGRHPSPCQFTITTPKAELAPVTTSLGLGVKPGQSVTGSRDTRMGTGPFSSSGHTAEKVPFGTTGGPPAHLLTPSPLSGPGGSSLLEKFELESGALTLPGGHASGDELDKMESSLVASELPLLIEDLLEHEKKELQKKQQLSAQLQPVQQQQPQQHSLLSTPGPGQAVSLPHEGSSPSLAGPQQQLALGLGGSRQPGLAQPLMPNQPPAHALQQRLAPSMAMVSNQGHMLSGQHGGQAGLVPQQNPQPVLAQKPMGTVPPSMCMKPQQLAMQQQLANSFFPDTDLDKFAAEDIIDPIAKAKMVALKGIKKVMAQGSIGVAPGMNRQQVSLLAQRLSGGPGSDLQNHVAAGSGQERGAGDSSQPRPNPPTFAQGVINEADQRQYEEWLFHTQQLLQMQLKVLEEQIGVHRKSRKALCAKQRTAKKAGREFPEADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGGQAAGLRLTPGGMALPGQPGGPFLNTTLAQQQQQQHSGGAGALAGPSGGFFPGNLALRGLGPDSRLLQERQLQLQQQRMQLAQKLQQQQQQHLLGQVAIQQQQQQGPGVQANQALGPKPQGLLPPSSHQGLLVQQLSPQPPPGPQGMLGPAQVAVLQQQQPHPGALGPQGPHRQVLLTQPRVLSSPQMAQQGQGLMGHRLVTSQQQQQQQHQQQGSMAGLSHLQQGLMPHSGQPKVGAQPMAALQQQQLQQQQQQQQLQQHQQLQQQQQQLQQQQQQQQLQQQQQQLQQQQQQQQLQQQQQQQQLQQQQQQQQQLQQQQQQQQLQQQQQQQQLQQQQQQQQLQQQQQQQLQQQQQQQQLQQQQQQLQQQQQQQQLQQQQQIGLLSQSRALLSPQQQQQQQQMTLGPGMPAKPLQHFSSPGALGPTLILTGKEQSIVETALPSEASEGSSTHQGGPLPMGTVPESVAPEPGEVKPSLSGDSQLLLVQPQAQPQPNSLQLQPPLRLPGQQQPPVNLLHTAGAGSHGQPGSGSSEASSVPHLLAQSSVSLGEQPGSVTQNLLSSQQPLGLERPMQNNIGPQPAKPGSVPQSGQSLPGAGVMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLHALLMQRQLQQSQAARQAPPYQEPGTQPSPLQGLLGRQPQLGGFPGSQTGPLQELGAGLRPQGPPRLPAPQGALSTGPVLGPVHPTPPPSSPQEPKRPSSQLPSPSSQLPSEAQLPTTQPGTPKPQGPPLELPPGRVSPAAAQLADTFFGKGLGPWDPPDHLAEAQKLEQSSLVPGHLDQVNGQVVPEPPHLNIKQEPREEPCALGSQAVKREANGEPVGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGPEGLRAEINGHIDSKLAGLEQKPQGTPSTKEDTAARKPLTPKPKRVQKASDRLVSSRKKLRKEDGVRASEALLKQLKQELSLLPLTEPTITANFSLFAPFGSGCPISGQCQLRGAFGSGVLPTGPDYYSQLLTKKMVNGVTPSEELGEHPKDAACARDTEGVLRDASEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPQLGSGRWEQDDRALSPVIPIIPRASIPVFPESKPYGVLDLETTRKLPAPTWEKGKGSEVSVMLTVSAAAAKNLNGMMVAVAELLSMKIPNSYEVLFPESPARAGIEPKKGEAEGPGGKEKSLGGKSPEAGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPAQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPAEPLVELPAEPSAEPPIPSPLPLASSPESTRPKPRARPPEEGEDSRPPRLKKWKGVRWKRLRLLLTIQKGGVRQEDEREVAEFMEQLGTALRPDKVPRDMRRCCFCHEEGDGATDGPARLLNLDLDLWVHLNCALWSTEVYETQGGALMNVEVALHRGLLTKCSLCQRTGATSSCNRMRCPNVYHFACAIRAKCMFFKDKTMLCPMHKIKGPCEQELSSFAVFRRVYIERDEVKQIASIIQRGERLHMFRVGGLVFHAIGQLLPHQMADFHSATALYPVGYEATRIYWSLRTNNRRCCYRCSIGENNGRPEFVIKVMEQGLEDMVFTDASPQAVWNRIIEPVAAMRKEADMLRLFPEYLKGEELFGLTVHAVLRIAESLPGVESCQNYLFRYGRHPLMELPLMINPTGCARSEPKILTHYKRVFTSIISFDPHNNLMRPHTLNSTSMSKAYQSTFTGETNTPYSKQFVHSKSSQYRRLRTEWKNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQHKIPCHCGAWNCRKWMN", "length": 5611, "header": "tr|A0A3Q1LM54-1|E1B9N8_BOVIN Computationally mapped isoform of Histone-lysine N-methyltransferase 2D OS=Bos taurus OX=9913 GN=KMT2D PE=4 SV=3 CANONICAL=E1B9N8-1" }, "locus": { "chromosome": "5", "start_pos": 30796547, "end_pos": 30764387, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067538.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067538.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057914.3", "url": "https://www.ensembl.org/id/ENSBTAP00000057914.3" } ] } }, { "isoform_ac": "E1B9N8-1", "url": "https://www.uniprot.org/uniprotkb/E1B9N8/entry#E1B9N8-1", "sequence": { "sequence": "MDSPKPPGEDKDSEPAADGPAASEESGATEPDLPKPHVGEVSVPSSGGPRLQEPPQDCSGGPVRRCALCNCGEPSLHGQRELRRFELPFDWPRCPVVSPGGNPGPSEGALPSEDLSQIGFPEGLTPAHLGEPGGSCWAHHWCAAWSAGVWGQEGPELCGVDKAIFSGISQRCSHCTRLGASIPCRSPGCSRLYHFPCATASGSFLSMKTLQLLCPEHSEGATHLEEARCAVCEGPGELCDLFFCTSCGHHYHGACLDTALTARKRAGWQCPECKVCQACRKPGNDSKMLVCETCDKGYHTFCLKPPMEELPAHSWKCKACRVCRACGAGSAELNPNSEWFENYSLCHRCHKAPGGQPVSSLAEQHPPVCSRFSPLEPGATPTDEPNSLYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGREGAQLEPQLEAPLNEEMPLLPPPEESPLSPPPEDSPTSPPPEASRLSPPPEDSPLSPPPEESPLSPPPESPPFSSPEDSPPHPPLDTPLPPPPEASPLSPPLEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASCLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEDLPMSPPPEVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDPPASPPPEDLLVSLPLEESPLLPLPEELRLCPRPEEPHLSPQPEKPRLSPAPQEPRLSPASQEPRLSPAPQEPCLSPAPEEPRLSPAPQQPCLSPAPEEPRLSPAPQQPHLSPVPQQPHLSPAPEEPRLSPASKELRLSPAPQEPCLSPAPQELHLSPVPEEPHLSLASEEPRLSPQPEEPCLSPRPEEPRLSPRPEEPRLSPRPEEPRLTPRPEEPHLSPRPEEPIEEPSLCLASEELPLLLPPREPPLSPVLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITTVAPPALSPLGELEYPFDAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPMGPASPILMEPLPPRCSPLLQHSLPPSNSPPSQCSPALPLLVPSPLSPMDKAVEVSEEAEPQKMETEKAPEPECPALEPSPTSPLPSPLGNLSCPAPSPAPALDDFCGLGEDTAPLDGTDTPGSQPEAGQTPGSLASELKGSPVLLDSEELAPVTPMEVYGPECKQAGQGSPCEEQEEPRAPVAPTPPILIKSDIVNEISNLSQGDASASFPGSEPLLGSPDPEGGGSLSMELGVSTDVSPARDEGSLRLCTDSLPETDDSLLCDAGTAIGGGKAEGDKGRRRSSPARSRIKQGRSSSFPGRRRPRGGAHGGRGRGRARLKSTTSSIETLVVADIDSSPSKEEEDDDDDTMQNTVVLFSNTDKFVLMQDMCVVCGSFGRGAEGHLLACSQCSQCYHPYCVNSKITKVMLLKGWRCVECIVCEVCGQASDPSRLLLCDDCDISYHTYCLDPPLLTVPKGGWKCKWCVSCMQCGAASPGFHCEWQNSYTHCGPCASLVTCPICHAPYVEEDLLIQCRHCERWMHAGCESLFTEDDVEQAADEGFDCVSCQPYVVKPAAPVAPPELVPMKVKEPEPQYFRFEGVWLTETGMAVLRNLTMSPLHKRRQRRGRPGLPGEAGLEGAEPSEVLGPDDKKDGDLDTDELLKAEGSVEHMECEIKLEGPVSPDGEPGKEETEESKKRKRKPYRPGIGGFMVRQRKSHTRVKKGPAAQAEVLSGDGQPDEGETVLPADLPAEGSVDQGLADGDEKKKQQRRGRKKNKLEDMFPAYLQEAFFGKELLDLSRKALFAVGVGRPSFGLGTPKAKGDGGSERKELPTSQKGDDGPDVADEESRGPEGKADTPGPEDGGIKASPVPSDPEKPGTPGEGMLSSDLDRIPTEELPKMESKDLQQLFKDVLGSEREQHLGCGTPGLDGSRTPLQRPFLQGGLPLGNLPSNSPMDSYPGLCQSPFLDSRERGGFFSPEPGEPDSPWTGSGGTTPSTPTTPTTEGEGDGLSYNQRSLQRWEKDEELGQLSTISPVLYANINFPSLKQDYPDWSSRCKQIMKLWRKVPAADKAPYLQKAKDNRAAHRINKVQKQAESQINKQTKVGDMARKTDRPALHLRIPPQPGALGSPPPAAAPTIFIGSPTPPAGLSTSADGFLKPPAGTVPGPDSPGELFLKLPPQVPAQVPSQDPFGLASAYALEPRFPTAPPTYPPYPSPTGAPAPPPTLGASSRPGTGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGGGGSKAAEPLLSPLPFGESRKALEVKKEELGGSSPSYGPPNLGFVDSPSSGPHLGGLELKAPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHSDIFRPGPYPDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPSEVAFKAGPLAHTPLGAGGFPAALPSGPAGELHAKVPSVQPPNFARSPGTSAFVGAPSPMRFTFPQAVGEPPLKPPVPQPGLPPPHGINSHFGPGPTMGKPQSTNYAVAAGNFRPSGSPLGPSSGPAGEGYGPSPLRPPSVLPQPTPDGPLPCLPHGATQRAGITSPVEKREDPGAGTGSSLAAPELSGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQMQRNTLRQEKETAAAAGAVGPPGNWGAEPSSPAFEQLGRGQTPFAGTQDKSSLVGLPPSKLGGPILGPGAFPSDDRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQQLWQQQQQATAAASMRLTMSARFPSTPGPELGRQTLGSPLAGISNRLPGPGEPVPGPAGPAQFIELRHNVQKGLGPGGPPFPGQGPPQRPRFYPVTEDSHRLAPEGLRGLAVSGLPPQKPSAPPAPELNNSLHPTPHTKGPNLPTGLELVSRPPSSTELGRPPPLTLEAGKLPCEDPELDDDFDAHKALEDDEELAHLGLGVDVAKGDDELGTLENLETNDPHLDDLLNGDEFDLLAYTDPELDTGDKKDIFNEHLRLVESANEKAEREALLRGVEPGPFGPEERPPPAADASEPRLASGLPEVKPKVEEGGRHPSPCQFTITTPKAELAPVTTSLGLGVKPGQSVTGSRDTRMGTGPFSSSGHTAEKVPFGTTGGPPAHLLTPSPLSGPGGSSLLEKFELESGALTLPGGHASGDELDKMESSLVASELPLLIEDLLEHEKKELQKKQQLSAQLQPVQQQQPQQHSLLSTPGPGQAVSLPHEGSSPSLAGPQQQLALGLGGSRQPGLAQPLMPNQPPAHALQQRLAPSMAMVSNQGHMLSGQHGGQAGLVPQQNPQPVLAQKPMGTVPPSMCMKPQQLAMQQQLANSFFPDTDLDKFAAEDIIDPIAKAKMVALKGIKKVMAQGSIGVAPGMNRQQVSLLAQRLSGGPGSDLQNHVAAGSGQERGAGDSSQPRPNPPTFAQGVINEADQRQYEEWLFHTQQLLQMQLKVLEEQIGVHRKSRKALCAKQRTAKKAGREFPEADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGGQAAGLRLTPGGMALPGQPGGPFLNTTLAQQQQQQHSGGAGALAGPSGGFFPGNLALRGLGPDSRLLQERQLQLQQQRMQLAQKLQQQQQQHLLGQVAIQQQQQQGPGVQANQALGPKPQGLLPPSSHQGLLVQQLSPQPPPGPQGMLGPAQVAVLQQQQPHPGALGPQGPHRQVLLTQPRVLSSPQMAQQGQGLMGHRLVTSQQQQQQQHQQQGSMAGLSHLQQGLMPHSGQPKVGAQPMAALQQQQLQQQQQQQQLQQHQQLQQQQQQLQQQQQQQQLQQQQQQLQQQQQQQQLQQQQQQQQLQQQQQQQQQLQQQQQQQQLQQQQQQQQLQQQQQQQQLQQQQQQQLQQQQQQQQLQQQQQQLQQQQQQQQLQQQQQIGLLSQSRALLSPQQQQQQQQMTLGPGMPAKPLQHFSSPGALGPTLILTGKEQSIVETALPSEASEGSSTHQGGPLPMGTVPESVAPEPGEVKPSLSGDSQLLLVQPQAQPQPNSLQLQPPLRLPGQQQPPVNLLHTAGAGSHGQPGSGSSEASSVPHLLAQSSVSLGEQPGSVTQNLLSSQQPLGLERPMQNNIGPQPAKPGSVPQSGQSLPGAGVMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLHALLMQRQLQQSQAARQAPPYQEPGTQPSPLQGLLGRQPQLGGFPGSQTGPLQELGAGLRPQGPPRLPAPQGALSTGPVLGPVHPTPPPSSPQEPKRPSSQLPSPSSQLPSEAQLPTTQPGTPKPQGPPLELPPGRVSPAAAQLADTFFGKGLGPWDPPDHLAEAQKLEQSSLVPGHLDQVNGQVVPEPPHLNIKQEPREEPCALGSQAVKREANGEPVGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGPEGLRAEINGHIDSKLAGLEQKPQGTPSTKEDTAARKPLTPKPKRVQKASDRLVSSRKKLRKEDGVRASEALLKQLKQELSLLPLTEPTITANFSLFAPFGSGCPISGQCQLRGAFGSGVLPTGPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAACARDTEGVLRDASEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPQLGSGRWEQDDRALSPVIPIIPRASIPVFPESKPYGVLDLETTRKLPAPTWEKGKGSEVSVMLTVSAAAAKNLNGMMVAVAELLSMKIPNSYEVLFPESPARAGIEPKKGEAEGPGGKEKSLGGKSPEAGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPAQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPAEPLVELPAEPSAEPPIPSPLPLASSPESTRPKPRARPPEEGEDSRPPRLKKWKGVRWKRLRLLLTIQKGGVRQEDEREVAEFMEQLGTALRPDKVPRDMRRCCFCHEEGDGATDGPARLLNLDLDLWVHLNCALWSTEVYETQGGALMNVEVALHRGLLTKCSLCQRTGATSSCNRMRCPNVYHFACAIRAKCMFFKDKTMLCPMHKIKGPCEQELSSFAVFRRVYIERDEVKQIASIIQRGERLHMFRVGGLVFHAIGQLLPHQMADFHSATALYPVGYEATRIYWSLRTNNRRCCYRCSIGENNGRPEFVIKVMEQGLEDMVFTDASPQAVWNRIIEPVAAMRKEADMLRLFPEYLKGEELFGLTVHAVLRIAESLPGVESCQNYLFRYGRHPLMELPLMINPTGCARSEPKILTHYKRPHTLNSTSMSKAYQSTFTGETNTPYSKQFVHSKSSQYRRLRTEWKNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQHKIPCHCGAWNCRKWMN", 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{ "start_pos": 2974, "end_pos": 2976 }, { "start_pos": 342, "end_pos": 344 }, { "start_pos": 3702, "end_pos": 3704 }, { "start_pos": 4657, "end_pos": 4659 }, { "start_pos": 4700, "end_pos": 4702 }, { "start_pos": 4771, "end_pos": 4773 }, { "start_pos": 4982, "end_pos": 4984 }, { "start_pos": 5441, "end_pos": 5443 }, { "start_pos": 5559, "end_pos": 5561 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 13 }, { "field": "total_sites", "count": 13 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 13 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 13 }, { "field": "exact_o_linked_sites", "count": 13 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 13 }, { "field": "total_sites", "count": 13 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 13 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 13 }, { "field": "exact_o_linked_sites", "count": 13 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDG4-1", "uniprot_ac": "E1BDG4", "uniprot_id": "E1BDG4_BOVIN", "mass": { "chemical_mass": 69774.0, "monoisotopic_mass": 69774.0 }, "refseq": { "ac": "NP_001039880", "name": "serine/threonine-protein kinase MAK", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039880" }, "gene_names": [ { "name": "MAK", "type": "recommended", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "name": "MAK", "type": "synonym", "evidence": [ { "id": "NP_001039880", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039880" } ] } ], "protein_names": [ { "name": "non-specific serine/threonine protein kinase", "type": "recommended", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4/entry#names_and_taxonomy" } ] }, { "name": "serine/threonine-protein kinase MAK", "type": "synonym", "evidence": [ { "id": "NP_001039880", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039880" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAK", "url": "https://www.uniprot.org/uniprotkb/E1BDG4", "locus": { "chromosome": "23", "start_pos": 45399868, "end_pos": 45349811, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014053", "url": "https://www.ensembl.org/id/ENSBTAG00000014053" } ] } } ], "crossref": [ { "id": "E1BDG4", "url": "https://alphafold.ebi.ac.uk/entry/E1BDG4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014053", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014053", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07830", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07830", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "536048", "url": "https://www.ncbi.nlm.nih.gov/gene/536048", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050117", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050117", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536048", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536048", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MNILTHA", "url": "https://omabrowser.org/oma/group/MNILTHA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR24055", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24055", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039880", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M8E0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8E0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8E0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8E0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLR2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDG4-1", "url": "https://www.uniprot.org/uniprotkb/E1BDG4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSAYSSPIDVWAVGSIMAELYTLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSHHLESKQPLNKLVQPLEPKPSAADPEPQPLPDINDQAAGPPQLKNSHQPLRSIQPPQNVGVQPAPKQHSQQKRPPTLFPSIVKSMPTKPGGALGHKGARRRWGQAVCKAGDGWADLEDSDFGASHSKKPSMGSSKETRSKESPFRLPESVPAGSSYSTRENKSLPAAVTLKSDSELSAASTAKQYYLKQSRYLPGVNPKNVSMVASGKDMNPYVWNNRLFPKSLGPLGAELAFRRNNTGNLGSYAPYNQSGYIPSFFKKEVGSAGQRIHLAPIGATASEYPWNTKTGRGQFSGPTYNPTAKNLNIVNRAQPVSSVHGRTDWVAKYGGHR", "length": 623, "header": "tr|E1BDG4-1|E1BDG4_BOVIN Isoform 1 of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=MAK PE=3 SV=1 CANONICAL=E1BDG4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M8E0-1", "url": "https://www.uniprot.org/uniprotkb/E1BDG4/entry#A0A3Q1M8E0-1", "sequence": { "sequence": "MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSAYSSPIDVWAVGSIMAELYTLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSHHLESKQPLNKLVQPLEPKPSAADPEPQPLPDINDQAAGPPQLKNSHQPLRSIQPPQNVGVQPAPKQHSQQKRPPTLFPSIVKSMPTKPGGALGHKGARRRWGQAVCKAGDGWADLEDSDFGASHSKKPSMGSSKETRSKESPFRLPESVPAGSSYSTRENKSLPAAVTLKSDSELSAASTAKQYYLKQSRYLPGVNPKNVSMVASGKDMNPYVWNNRLFPKSLGPLGAELAFRRNNTEESIIKPIEKLSCNESFPEKLEDPQGNLGSYAPYNQSGYIPSFFKKEVGSAGQRIHLAPIGATASEYPWNTKTGRGQFSGPTYNPTAKNLNIVNRAQPVSSVHGRTDWVAKYGGHR", "length": 648, "header": "tr|A0A3Q1M8E0-1|E1BDG4_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=MAK PE=3 SV=2 CANONICAL=E1BDG4-1" }, "locus": { "chromosome": "23", "start_pos": 45399113, "end_pos": 45357399, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084589.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084589.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066707.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066707.2" } ] } }, { "isoform_ac": "A0AAA9SLR2-1", "url": "https://www.uniprot.org/uniprotkb/E1BDG4/entry#A0AAA9SLR2-1", "sequence": { "sequence": "MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSAYSSPIDVWAVGSIMAELYTLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSHHLESKQPLNKLVQPLEPKPSAADPEPQPLPDINDQAAGPPQLKNSHQPLRSIQPPQNVGVQPAPKQHSQQKRPPTLFPSIVKSMPTKPGGALGHKGARRRWGQAVCKAGDGWADLEDSDFGASHSKKPSMGSSKETRSKESPFRLPESVPAGSSYSTRENKSLPAAVTLKSDSELSAASTAKQYYLKQSRYLPGVNPKNVSMVASGKDMNPYVWNNRLFPKSLGPLGAELAFRRNNTEYPWNTKTGRGQFSGPTYNPTAKNLNIVNRAQPVSSVHGRTDWVAKYGGHR", "length": 583, "header": "tr|A0AAA9SLR2-1|E1BDG4_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=MAK PE=3 SV=1 CANONICAL=E1BDG4-1" }, "locus": { "chromosome": "23", "start_pos": 45399113, "end_pos": 45357399, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114169.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114169.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087297.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087297.1" } ] } }, { "isoform_ac": "E1BDG4-1", "url": "https://www.uniprot.org/uniprotkb/E1BDG4/entry#E1BDG4-1", "sequence": { "sequence": "MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSAYSSPIDVWAVGSIMAELYTLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSHHLESKQPLNKLVQPLEPKPSAADPEPQPLPDINDQAAGPPQLKNSHQPLRSIQPPQNVGVQPAPKQHSQQKRPPTLFPSIVKSMPTKPGGALGHKGARRRWGQAVCKAGDGWADLEDSDFGASHSKKPSMGSSKETRSKESPFRLPESVPAGSSYSTRENKSLPAAVTLKSDSELSAASTAKQYYLKQSRYLPGVNPKNVSMVASGKDMNPYVWNNRLFPKSLGPLGAELAFRRNNTGNLGSYAPYNQSGYIPSFFKKEVGSAGQRIHLAPIGATASEYPWNTKTGRGQFSGPTYNPTAKNLNIVNRAQPVSSVHGRTDWVAKYGGHR", "length": 623, "header": "tr|E1BDG4-1|E1BDG4_BOVIN Isoform 1 of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=MAK PE=3 SV=1 CANONICAL=E1BDG4-1" }, "locus": { "chromosome": "23", "start_pos": 45399113, "end_pos": 45357399, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034653.4", "url": "https://www.ensembl.org/id/ENSBTAT00000034653.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034540.3", "url": "https://www.ensembl.org/id/ENSBTAP00000034540.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:536048", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536048", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2N185-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "Mak", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYTFRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASSEAIQLMMNMLNWDPKKRPTASQALKHPYFQVGQVLGPSAHHQDAKQTLNKQQQPLEPKPCISEQDPKSLPNILDQPAGPPQPKQDHQPLQTIQPPQNPAIQPSSKQQGHQKPPQTIFPSIIKTMPTKPVNTMSHKGARRRWGQTVFKSGDSCDNFEDCDSGASHSKKPSMSAFKEKKKREPPFRFPETESPGSTLSKGENRSLHGAVSLKSDTNVTTASTAKQYYLKQSRYLPGVNPKNVSLVASGKDINPHAWSNQLFPKSLGSMGAELAFKRNNAEESIIRPIEKLSCTEKSAEKLEDPQGNLGSYTTYNQTGYMPSFLKKEVGSAGQRIHLAPLGATASEYTWNAKPSRGQFSGRTYNPTAKNLSIVNRTQPVPSVHGRTDWVAKYGGHR", "length": 648 }, "evidence": [ { "id": "E1BDG4", "url": "https://omabrowser.org/oma/group/E1BDG4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1RV90-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "MAK", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYTLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCAPINLKTLIPNASNEAIQLMTEMLSWDPKKRPTASQALKHPYFQVGQVLGPSSHHLESKQPLNKQVQPLESKPSVGDLEPKLLPDINDQTAGQPQPRNSHQPLQSIQPPQDTSGQQAPKQQSQQKQPQTLFPRIVKNMPIKPNGTLGHKGARRRWGPTVFKAGDSGEESEDYDFGASHSKKPSMGVFKETRRKDSPFRLPEPVPTGSNHSSGENKSLTAAGSLKSDSELSTASAAKQYYLKQSRYLPGVNPKNVSLVTRGKDINPYSWNNQLFPKSLGPIGAELAFKRNNAGTLGSYATYNQSGYIPSFLKKEVGSAGQRIPLVPLGATASEYSWNTKMGRGQFSGPTYNPTAKNLNMVNRAQPVPSVHGRTDWVAKYGGHR", "length": 623 }, "evidence": [ { "id": "E1BDG4", "url": "https://omabrowser.org/oma/group/E1BDG4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q04859-1", "protein_name": "Serine/threonine-protein kinase MAK", "gene_name": "Mak", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNRYTTMKQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFVFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYTFRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCIPINLKTLIPNASSEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGSSAHHLDTKQTLHKQLQPLEPKPSSSERDPKPLPNILDQPAGQPQPKQGHQPLQTIQPPQNTVTHPPPKQQGHQKPPQTMFPSIIKTIPVNSVSTLGHKGARRRWGQTVFKSGDSCDDIEDDLGASHSKKPSMEACKEKKKESPFRFPDSGLPVSNHFKGENRNLHASVSLKSDPNLSTASTAKQYYLKQSRYLPGVNPKNVSLVAGGKDINSHSWNNQLFPKSLGSMGADLSFKRSNAAGNLGSYTTYNQTGYMPSFLKKEVGSAGQRIQLAPLGASASDYTWSTKTGRGQFSGRTYNPTAKNLNIVNRTQPVPSVHGRTDWVAKYGGHR", "length": 622 }, "evidence": [ { "id": "E1BDG4", "url": "https://omabrowser.org/oma/group/E1BDG4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 14, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" }, { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" }, { "name": "photoreceptor inner segment", "id": "GO:0001917", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001917", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" }, { "name": "photoreceptor connecting cilium", "id": "GO:0032391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032391", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" }, { "name": "photoreceptor outer segment", "id": "GO:0001750", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001750", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" }, { "name": "mitotic spindle", "id": "GO:0072686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "photoreceptor cell maintenance", "id": "GO:0045494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045494", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" }, { "name": "intraciliary transport", "id": "GO:0042073", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042073", "evidence": [ { "database": "UniProtKB", "id": "E1BDG4", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" }, { "start_pos": 252, "end_pos": 254, "annotation": "n_glycosylation_sequon" }, { "start_pos": 455, "end_pos": 457, "annotation": "n_glycosylation_sequon" }, { "start_pos": 494, "end_pos": 496, "annotation": "n_glycosylation_sequon" }, { "start_pos": 530, "end_pos": 532, "annotation": "n_glycosylation_sequon" }, { "start_pos": 542, "end_pos": 544, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", 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O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { 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"https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", 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"database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-112382", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112382", "resource": "Reactome", "description": "Formation of RNA Pol II elongation complex" }, { "id": "R-BTA-113418", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-113418", "resource": "Reactome", "description": "Formation of the Early Elongation Complex" }, { "id": "R-BTA-674695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-674695", "resource": "Reactome", "description": "RNA Polymerase II Pre-transcription Events" }, { "id": "R-BTA-6796648", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6796648", "resource": "Reactome", "description": "TP53 Regulates Transcription of DNA Repair Genes" }, { "id": "R-BTA-6807505", "name": "", "url": 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"table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BAQ1-1", "uniprot_ac": "E1BAQ1", "uniprot_id": "E1BAQ1_BOVIN", "mass": { "chemical_mass": 62394.0, "monoisotopic_mass": 62394.0 }, "refseq": { "ac": "NP_001179336", "name": "cell division control protein 6 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179336" }, "gene_names": [ { "name": "CDC6", "type": "recommended", "evidence": [ { "id": "E1BAQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" } ] }, { "name": "CDC6", "type": "synonym", "evidence": [ { "id": "NP_001179336", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179336" } ] } ], "protein_names": [ { "name": "Cell division control protein", "type": "recommended", "evidence": [ { "id": "E1BAQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1/entry#names_and_taxonomy" } ] }, { "name": "cell division control protein 6 homolog", "type": "synonym", "evidence": [ { "id": "NP_001179336", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179336" } ] }, { "name": "cell division cycle 6 homolog", "type": "synonym", "evidence": [ { "id": "NP_001179336", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179336" } ] } ], "function": [ { "annotation": "Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1#function" }, { "database": "UniProtKB", "id": "PIRNR001767", "url": "https://www.uniprot.org/uniprotkb/PIRNR001767#function" }, { "database": "UniProtKB", "id": "ARBA00056036", "url": "https://www.uniprot.org/uniprotkb/ARBA00056036#function" }, { "database": "UniProtKB", "id": "A0A3Q1MVB0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVB0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAQ1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDC6", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1", "locus": { "chromosome": "19", "start_pos": 40546070, "end_pos": 40527872, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010384", "url": "https://www.ensembl.org/id/ENSBTAG00000010384" } ] } } ], "crossref": [ { "id": "E1BAQ1", "url": "https://alphafold.ebi.ac.uk/entry/E1BAQ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010384", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010384", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00009", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00009", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08768", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08768", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515301", "url": "https://www.ncbi.nlm.nih.gov/gene/515301", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015163", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049945", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049945", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050311", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050311", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054425", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054425", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515301", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515301", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WPTDEVY", "url": "https://omabrowser.org/oma/group/WPTDEVY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MVB0", "url": "https://www.orthodb.org/?gene=A0A3Q1MVB0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BAQ1", "url": "https://www.orthodb.org/?gene=E1BAQ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10763", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10763", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10763:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10763:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09079", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09079", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13401", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13401", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22606", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22606", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-176187", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176187", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68949", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68949", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68962", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68962", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-69017", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69017", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179336", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVB0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVB0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVB0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAQ1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAQ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRTRSQSQATISFPKKKPSRTVDKAKSSSDTKLELTNAQAILCSPRAEILPLSPRKRLGDDNLCNTPRLSPCSPPKQGKKENGPPRSQTSKGRRLVFDSQLTTKSPSKREHTRVHQNKIHPSVPKGQDITTNSEQRCPPEKESACLRLFKQEGTCYQQAKQVLTTAVPDQLPAREKEMDVIRNFLREHIYGKKAGSLYLSGAPGTGKTACLSRILQDLKKELKGFKTIVLNCMSLRSAQAVFPAIAQEICQEEVSRPAGKDMMRRLENHMTAEKGPMIVLVLDEMDQLDSRGQDVLYTLFEWPWLSNSRLVLIGIANTLDLTDRILPRLQAREKCKPQLLNFPPYTKNQIATILQDRLNQASNDQVLDNAAIQFCARKVSAVSGDVRKALDICRRAIEVVESDVKSQTILKPLSECKSPSESLVPKRVGVIHISQVISEVDGNRMTLSQEGAQDSFPLQQKILVCSLLLLTRRLKIKEVTLGKLHEAYSNVCRKQQVAAVAQSECLSLSGLLEARGIFGLKKNKETRFTKVSLKIEETEIEHALKDKALVGNILATGLP", "length": 560, "header": "tr|E1BAQ1-1|E1BAQ1_BOVIN Isoform 1 of Cell division control protein OS=Bos taurus OX=9913 GN=CDC6 PE=3 SV=1 CANONICAL=E1BAQ1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MVB0-1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1/entry#A0A3Q1MVB0-1", "sequence": { "sequence": "MELHIQLVWFAYALECRGCSELRVRAEEPCYCLERMGKSPRRLFTSCAAIMPRTRSQSQATISFPKKKPSRTVDKAKSSSDTKLELTNAQAILCSPRAEILPLSPRKRLGDDNLCNTPRLSPCSPPKQGKKENGPPRSQTSKGRRLVFDSQLTTKSPSKREHTRVHQNKIHPSVPKGQDITTNSEQRCPPEKESACLRLFKQEGTCYQQAKQVLTTAVPDQLPAREKEMDVIRNFLREHIYGKKAGSLYLSGAPGTGKTACLSRILQDLKKELKGFKTIVLNCMSLRSAQAVFPAIAQEICQEEVSRPAGKDMMRRLENHMTAEKGPMIVLVLDEMDQLDSRGQDVLYTLFEWPWLSNSRLVLIGIANTLDLTDRILPRLQAREKCKPQLLNFPPYTKNQIATILQDRLNQASNDQVLDNAAIQFCARKVSAVSGDVRKALDICRRAIEVVESDVKSQTILKPLSECKSPSESLVPKRVGVIHISQVISEVDGNRMTLSQEGAQDSFPLQQKILVCSLLLLTRRLKIKEVTLGKLHEAYSNVCRKQQVAAVAQSECLSLSGLLEARGIFGLKKNKETRFTKVSLKIEETEIEHALKDKALVGNILATGLP", "length": 610, "header": "tr|A0A3Q1MVB0-1|E1BAQ1_BOVIN Computationally mapped isoform of Cell division control protein OS=Bos taurus OX=9913 GN=CDC6 PE=3 SV=2 CANONICAL=E1BAQ1-1" }, "locus": { "chromosome": "19", "start_pos": 40545466, "end_pos": 40528071, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083861.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083861.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058917.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058917.2" } ] } }, { "isoform_ac": "E1BAQ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1/entry#E1BAQ1-1", "sequence": { "sequence": "MPRTRSQSQATISFPKKKPSRTVDKAKSSSDTKLELTNAQAILCSPRAEILPLSPRKRLGDDNLCNTPRLSPCSPPKQGKKENGPPRSQTSKGRRLVFDSQLTTKSPSKREHTRVHQNKIHPSVPKGQDITTNSEQRCPPEKESACLRLFKQEGTCYQQAKQVLTTAVPDQLPAREKEMDVIRNFLREHIYGKKAGSLYLSGAPGTGKTACLSRILQDLKKELKGFKTIVLNCMSLRSAQAVFPAIAQEICQEEVSRPAGKDMMRRLENHMTAEKGPMIVLVLDEMDQLDSRGQDVLYTLFEWPWLSNSRLVLIGIANTLDLTDRILPRLQAREKCKPQLLNFPPYTKNQIATILQDRLNQASNDQVLDNAAIQFCARKVSAVSGDVRKALDICRRAIEVVESDVKSQTILKPLSECKSPSESLVPKRVGVIHISQVISEVDGNRMTLSQEGAQDSFPLQQKILVCSLLLLTRRLKIKEVTLGKLHEAYSNVCRKQQVAAVAQSECLSLSGLLEARGIFGLKKNKETRFTKVSLKIEETEIEHALKDKALVGNILATGLP", "length": 560, "header": "tr|E1BAQ1-1|E1BAQ1_BOVIN Isoform 1 of Cell division control protein OS=Bos taurus OX=9913 GN=CDC6 PE=3 SV=1 CANONICAL=E1BAQ1-1" }, "locus": { "chromosome": "19", "start_pos": 40545466, "end_pos": 40536151, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013706.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013706.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013706.4", "url": "https://www.ensembl.org/id/ENSBTAP00000013706.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515301", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515301", "resource": "KEGG Pathway" }, { "id": "R-BTA-176187", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176187", "resource": "Reactome", "description": "Activation of ATR in response to replication stress" }, { "id": "R-BTA-68689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68689", "resource": "Reactome", "description": "CDC6 association with the ORC:origin complex" }, { "id": "R-BTA-68949", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68949", "resource": "Reactome", "description": "Orc1 removal from chromatin" }, { "id": "R-BTA-68962", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68962", "resource": "Reactome", "description": "Activation of the pre-replicative complex" }, { "id": "R-BTA-69017", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69017", "resource": "Reactome", "description": "CDK-mediated phosphorylation and removal of Cdc6" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2TYA4-1", "protein_name": "Cell division control protein", "gene_name": "CDC6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSVARPQRQATIAFPRRRSARCNAAVLAKAPPADPDPSDPTAPSLSPVSPRPTEPAPITLSPRSTAQPLSPRKRLGDDNLCNVPHATPCSPAKRCKENRGCRVLFGDPTASPGKQSAAGPAVLQRGQETPQGSGRSAGLSRSRLFRQEGTCYQQAKRVLHAALPERLHGREREAAAVRQFLREHLAARRPGSLYIAGAPGTGKTACVSCVLRDCKDELAGSRSAVLNCMALSSAHAVFPAVAEQLGLPTAGAGGRELTRRLERALTAEGPMLLLVLDEMDQLGSRAQDVLYTIFEWPRLPGSRLVLIGLANALDLTERLLARLHTPPLPAPHLLRFAPYGREQLTAILHGRLEQLQGGPVLEPSALQFCARKVSAVSGDARKALDVCRRAVELVELEVRSQTLLQPLPGGDPTAAPCPVPKRVGLPQVSRVLSEVFGDRMAPGSPRARDAFPLQQKILVCSLLLLARHLRTRQVTLGKLHDAYSRVCRRQQLPAVDQTECLSLATLLESRGVLELKRAKDSRLTKVSLKVEEEEAQHALQDATLVGSILARGLF", "length": 554 }, "evidence": [ { "id": "E1BAQ1", "url": "https://omabrowser.org/oma/group/E1BAQ1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZRK7-1", "protein_name": "Cell division control protein", "gene_name": "Cdc6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPQTRSQTQATIDFPKKKQSKTLSKTNSRDSEVKLRNVQPVPTTPCADIKILPLSPRKRLGDDNLCNTPHLSPCSPPKLGRKENGPPRSHTRKGCRLIFDDELAVKASAPKEQDRVPQHQILSSAQRGQESETNPEQKCPPEKESACMRLFKQEGTCYQQAKLVLNTAVPDRLPAREQEMGVIRDFLKEHICGKKAGSLYLSGAPGTGKTACLSRILQDFKKEVKGFKTIVLNCMSLRNAQAVFPAIAQEIGREELCRPTGKDLMRKLEKHLTAERGPMIVLVLDEMDQLDSKGQDVLYTLFEWPWLSNSRLVLIGIANTLDLTDRILPRLEAREGCKPKLLNFPPYTRNQIAAILQDRLSQVSKDQVLDSAAIQFCARKVSAVSGDIRKALDVCRRAIEIVESDVRSQTVLKPLSECKSPCESLVPKRVGLAHISQVISGVDGNRVTLSQENTQDSLPLQQKILVCSLLLLTKRLKIKEVTLGKLYEAYSSVCRKQQVAAVDQSECLSLSGLLESRGIVGLKKNKESRLTKVSLKIEEKEIEHVLKGKAFIGNILAAGLP", "length": 561 }, "evidence": [ { "id": "E1BAQ1", "url": "https://omabrowser.org/oma/group/E1BAQ1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RXE3-1", "protein_name": "Cell division control protein", "gene_name": "CDC6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPQTRSQSQATINFPKKKLSQTLGKAKNSSDTKLELTNVKAIPRSPCEKILPLSPRKRLGDDNLCNTPRLPPCSPPKQGKKENGPPRSRTPKGRRLVFDNQPTIKSPSKREQAGVHQSKTRSSIRKDAEVTTSSEQRCPLEKESARMRLFKQEGTCYQQAKQVLTTAVPDQLPAREKEMDVLRNFLREHICGEKAGSLYLSGAPGTGKTACLSRILQDLKKELKGFKTVMLNCMSLRSAQAVFPAIAQEICQEEVSRPAGKDLMRKLENHMTAEKGPMIVLVLDEMDQLDSKGQDVLYTLFEWPWLSSSRLVLIGIANTLDLTDRILPRLQAREKCKPRLLNFPPYTKNQIATILQDRLNQASKDQVLDSAAVQFCARKVSAVSGDVRKALDVCRRAIEIVESDVKSQTLLKPLSECKSPSESLVPKRVGVIHISQVLSEVDGNRMALSQEGAQDCFPLQQKILVCSLLLLTRHLKTKEVTLGKLYEAYSNVCRKQQVAAVDQSECLSLSGLLEARGIFGLKKSKETRFTKVSLKIEEKEIEHAVKDKALVGKILATGLP", "length": 560 }, "evidence": [ { "id": "E1BAQ1", "url": "https://omabrowser.org/oma/group/E1BAQ1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O82387-1", "protein_name": "DNA replication factor CDC6", "gene_name": "CDC6", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MPAIAGPSSSPQKHVVGSRSESIGGVRSAEVNTSRKRKLISDSAAEVSATVVLPVNSISTPMKWKSPRRCAVSIPKTSDEEIKEDSNEKLENPVISVCLEVKSKWNPKDDEQMKAVKEALHVSKAPSTVVCREDEQRRVFEFVKGCMEQKKAGSLYICGCPGTGKSLSMEKVRLQAEEWAKQAGLHCPETVSVNCTSLTKSTDIFSKILGNYESGKKANGSFSPLQQLQRLFSQKQQQSRSKMMLIIADEMDYLITRDRGVLHELFMLTTLPLSRCILIGTVFCVINVHFLKSVSYGQTSFKFKVRICPPGVANAIDLADRFLPKLKSLNCKPLVVTFRAYSKDQILRILQERLVALPFVAFQSNALEICARKVSAASGDMRKALCVCRSALEILEIEVRGSIDQEPKGPVPECQVVKMDHMIAALSKTFKSPIVDTIQSLPQHQQIIVCSAAKAFRGSKKDRTIAELNKLYLEICKSSMITPAGITEFSNMCTVLNDQGILKLSLARDDKLKRVSLRVDEADITFALKEIRFFRNCLL", "length": 539 }, "evidence": [ { "id": "E1BAQ1", "url": "https://omabrowser.org/oma/group/E1BAQ1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "O89033-1", "protein_name": "DNA replication factor CDC6", "gene_name": "Cdc6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPQTRSQTQATIGFPKKKLSNTLKKPNSRDCEVKLRNVQPVPTTPCVDVKLLPLSPRKRLGDDNLCNTPRLSPCSPPKLGKKENGPPRSHTWKGCRLVFDDEPTFKASPPKEQDRVRQHQIRSSSAQRSPESKADPEQKCPPEKESVCIRLFKQEGTCYQQAKLVLNTAVPDRLPAREQEMGVIRNFLKEHICGKKAGSLYLSGAPGTGKTACLSRILQDFKKEVKGFKSILLNCMSLRSAQAVFPAIAQEIGREELCRPAGKDLMRKLEKHLTAEKGPMIVLVLDEMDQLDSKGQDVLYTLFEWPWLSNSRLVLIGIANTLDLTDRILPRLEARENCKPQLLNFPPYTRNQIAAILQDRLSQVSKDQVLDSAAIQFCARKVSAVSGDIRKALDVCRRAIEIVESDVRSQTVLKPLSECKSPSESPVPKRVGLAHISQVISEVDGNRVTLSQENTQDSLPLQQKILVCSLLLLTRRLKIKEVTLGKLYEAYSSICRKQQVTAVDQSECLSLSGLLESRGLVGLKKNKESRLTKVSLKIEEKEIEHVLNGKAFTGNILAAGLP", "length": 562 }, "evidence": [ { "id": "E1BAQ1", "url": "https://omabrowser.org/oma/group/E1BAQ1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P09119-1", "protein_name": "DNA replication factor CDC6", "gene_name": "CDC6", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSAIPITPTKRIRRNLFDDAPATPPRPLKRKKLQFTDVTPESSPEKLQFGSQSIFLRTKALLQKSSELVNLNSSDGALPARTAEYEQVMNFLAKAISEHRSDSLYITGPPGTGKTAQLDMIIRQKFQSLPLSLSTPRSKDVLRHTNPNLQNLSWFELPDGRLESVAVTSINCISLGEPSSIFQKIFDSFQDLNGPTLQIKNMQHLQKFLEPYHKKTTFVVVLDEMDRLLHANTSETQSVRTILELFLLAKLPTVSFVLIGMANSLDMKDRFLSRLNLDRGLLPQTIVFQPYTAEQMYEIVIQKMSSLPTIIFQPMAIKFAAKKCAGNTGDLRKLFDVLRGSIEIYELEKRFLLSPTRGSLNSAQVPLTPTTSPVKKSYPEPQGKIGLNYIAKVFSKFVNNNSTRTRIAKLNIQQKLILCTIIQSLKLNSDATIDESFDHYIKAITKTDTLAPLQRNEFLEICTILETCGLVSIKKTKCKGKTKRFVDKIDVDLDMREFYDEMTKISILKPFLH", "length": 513 }, "evidence": [ { "id": "E1BAQ1", "url": "https://omabrowser.org/oma/group/E1BAQ1/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q99741-1", "protein_name": "DNA replication factor CDC6", "gene_name": "CDC6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPQTRSQAQATISFPKRKLSRALNKAKNSSDAKLEPTNVQTVTCSPRVKALPLSPRKRLGDDNLCNTPHLPPCSPPKQGKKENGPPHSHTLKGRRLVFDNQLTIKSPSKRELAKVHQNKILSSVRKSQEITTNSEQRCPLKKESACVRLFKQEGTCYQQAKLVLNTAVPDRLPAREREMDVIRNFLREHICGKKAGSLYLSGAPGTGKTACLSRILQDLKKELKGFKTIMLNCMSLRTAQAVFPAIAQEICQEEVSRPAGKDMMRKLEKHMTAEKGPMIVLVLDEMDQLDSKGQDVLYTLFEWPWLSNSHLVLIGIANTLDLTDRILPRLQAREKCKPQLLNFPPYTRNQIVTILQDRLNQVSRDQVLDNAAVQFCARKVSAVSGDVRKALDVCRRAIEIVESDVKSQTILKPLSECKSPSEPLIPKRVGLIHISQVISEVDGNRMTLSQEGAQDSFPLQQKILVCSLMLLIRQLKIKEVTLGKLYEAYSKVCRKQQVAAVDQSECLSLSGLLEARGILGLKRNKETRLTKVFFKIEEKEIEHALKDKALIGNILATGLP", "length": 560 }, "evidence": [ { "id": "E1BAQ1", "url": "https://omabrowser.org/oma/group/E1BAQ1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "positive regulation of chromosome segregation", "id": "GO:0051984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051984", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" } ], "pmid": "" }, { "name": "regulation of mitotic metaphase/anaphase transition", "id": "GO:0030071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030071", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" } ], "pmid": "" }, { "name": "DNA replication initiation", "id": "GO:0006270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006270", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" } ], "pmid": "" }, { "name": "positive regulation of cytokinesis", "id": "GO:0032467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032467", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" } ], "pmid": "" }, { "name": "mitotic DNA replication checkpoint signaling", "id": "GO:0033314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033314", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" } ], "pmid": "" }, { "name": "spindle midzone", "id": "GO:0051233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051233", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" } ], "pmid": "" }, { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" } ], "pmid": "" }, { "name": "protein serine/threonine kinase binding", "id": "GO:0120283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120283", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" } ], "pmid": "" }, { "name": "DNA replication origin binding", "id": "GO:0003688", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003688", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" }, { "id": "SM00382", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AAA+ ATPase", "eco_id": "ECO_0000259", "start_pos": 194, "end_pos": 333, "start_aa": "Lys", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BAQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAQ1" }, { "id": "SM01074", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01074" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cdc6 C-terminal", "eco_id": "ECO_0000259", "start_pos": 465, "end_pos": 545, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BC74-1", "uniprot_ac": "E1BC74", "uniprot_id": "E1BC74_BOVIN", "mass": { "chemical_mass": 58185.0, "monoisotopic_mass": 58185.0 }, "refseq": {}, "gene_names": [ { "name": "ANTXR1", "type": "recommended", "evidence": [ { "id": "E1BC74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC74" } ] } ], "protein_names": [ { "name": "Anthrax toxin receptor 1", "type": "recommended", "evidence": [ { "id": "E1BC74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC74/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton and thereby plays an important role in normal extracellular matrix (ECM) homeostasis. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. May also act as a receptor for PLAU. Upon ligand binding, stimulates the phosphorylation of EGFR and ERK1/2.", "evidence": [ { "database": "UniProtKB", "id": "E1BC74", "url": "https://www.uniprot.org/uniprotkb/E1BC74#function" }, { "database": "UniProtKB", "id": "ARBA00093334", "url": "https://www.uniprot.org/uniprotkb/ARBA00093334#function" }, { "database": "UniProtKB", "id": "A0AAA9S9W5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9W5#function" }, { "database": "UniProtKB", "id": "A0AAA9SA14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA14#function" }, { "database": "UniProtKB", "id": "A0A3Q1MVZ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVZ0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BC74", "url": "https://www.uniprot.org/uniprotkb/E1BC74" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANTXR1", "url": "https://www.uniprot.org/uniprotkb/E1BC74", "locus": { "chromosome": "11", "start_pos": 67615441, "end_pos": 67359835, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007808", "url": "https://www.ensembl.org/id/ENSBTAG00000007808" } ] } } ], "crossref": [ { "id": "E1BC74", "url": "https://alphafold.ebi.ac.uk/entry/E1BC74", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007808", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007808", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01474", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01474", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616010", "url": "https://www.ncbi.nlm.nih.gov/gene/616010", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008399", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008399", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008400", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008400", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017360", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017360", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616010", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616010", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ANNMRRP", "url": "https://omabrowser.org/oma/group/ANNMRRP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MVZ0", "url": "https://www.orthodb.org/?gene=A0A3Q1MVZ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BC74", "url": "https://www.orthodb.org/?gene=E1BC74", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16059", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16059", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16059:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16059:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00092", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00092", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05586", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05586", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05587", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05587", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MVZ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVZ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVZ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVZ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9W5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9W5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9W5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9W5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA14-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC74", "url": "https://www.uniprot.org/uniprotkb/E1BC74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC74-1", "url": "https://www.uniprot.org/uniprotkb/E1BC74-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATVEQKALGIGFKCLSLATFVLICAGQGGRREEGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTQGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENSQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINESVTLNEKPFTVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPPAEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGTYKNMVKDFQCWNGNWSIVTSLDCRSREDLSTLSYPLAA", "length": 518, "header": "tr|E1BC74-1|E1BC74_BOVIN Isoform 1 of Anthrax toxin receptor 1 OS=Bos taurus OX=9913 GN=ANTXR1 PE=3 SV=3 CANONICAL=E1BC74-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MVZ0-1", "url": "https://www.uniprot.org/uniprotkb/E1BC74/entry#A0A3Q1MVZ0-1", "sequence": { "sequence": "MATVEQKALGIGFKCLSLATFVLICAGQGGRREEGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTQGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENSQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINESVTLNEKPFTVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPPAEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGRCINFTRVKNNPPAKYPLNNAYHTTSPPPAPIYTPPPPAPHCPPPPPSAPTPPIPSPPSILPPPPQAPPPNRAPPPSRPPPRPSV", "length": 564, "header": "tr|A0A3Q1MVZ0-1|E1BC74_BOVIN Computationally mapped isoform of Anthrax toxin receptor 1 OS=Bos taurus OX=9913 GN=ANTXR1 PE=3 SV=1 CANONICAL=E1BC74-1" }, "locus": { "chromosome": "11", "start_pos": 67614437, "end_pos": 67360169, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072891.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072891.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059404.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059404.1" } ] } }, { "isoform_ac": "A0AAA9S9W5-1", "url": "https://www.uniprot.org/uniprotkb/E1BC74/entry#A0AAA9S9W5-1", "sequence": { "sequence": "MATVEQKALGIGFKCLSLATFVLICAGQGGRREEGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTQGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENSQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINESVTLNEKPFTVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCDELWFLVLSLERLKDHRNIRMPNSDVRCCL", "length": 347, "header": "tr|A0AAA9S9W5-1|E1BC74_BOVIN Computationally mapped isoform of Anthrax toxin receptor 1 OS=Bos taurus OX=9913 GN=ANTXR1 PE=3 SV=1 CANONICAL=E1BC74-1" }, "locus": { "chromosome": "11", "start_pos": 67494194, "end_pos": 67360169, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096371.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096371.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082871.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082871.1" } ] } }, { "isoform_ac": "A0AAA9SA14-1", "url": "https://www.uniprot.org/uniprotkb/E1BC74/entry#A0AAA9SA14-1", "sequence": { "sequence": "MATVEQKALGIGFKCLSLATFVLICAGQGGRREEGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTQGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENSQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINESVTLSKFLRSLGVSAAGFWEGSSQYLPEKPHPG", "length": 296, "header": "tr|A0AAA9SA14-1|E1BC74_BOVIN Computationally mapped isoform of Anthrax toxin receptor 1 OS=Bos taurus OX=9913 GN=ANTXR1 PE=3 SV=1 CANONICAL=E1BC74-1" }, "locus": { "chromosome": "11", "start_pos": 67454612, "end_pos": 67360169, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099401.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099401.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080268.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080268.1" } ] } }, { "isoform_ac": "E1BC74-1", "url": "https://www.uniprot.org/uniprotkb/E1BC74/entry#E1BC74-1", "sequence": { "sequence": "MATVEQKALGIGFKCLSLATFVLICAGQGGRREEGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTQGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENSQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINESVTLNEKPFTVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPPAEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGTYKNMVKDFQCWNGNWSIVTSLDCRSREDLSTLSYPLAA", "length": 518, "header": "tr|E1BC74-1|E1BC74_BOVIN Isoform 1 of Anthrax toxin receptor 1 OS=Bos taurus OX=9913 GN=ANTXR1 PE=3 SV=3 CANONICAL=E1BC74-1" }, "locus": { "chromosome": "11", "start_pos": 67597280, "end_pos": 67360169, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061292.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061292.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053745.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053745.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616010", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616010", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q0PMD2-1", "protein_name": "Anthrax toxin receptor 1", "gene_name": "Antxr1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDRAGRLGTGLRGLCVAALVLVCAGQGGRREDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHRFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENSQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFAVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPPVEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGRCINFTRVKNSQPAKYPLNNSYHSSSPPPAPIYTPPPPAPHCPPPAPSAPTPPIPSPPSTLPPPPQAPPPNRAPPPSRPPPRPSV", "length": 562 }, "evidence": [ { "id": "E1BC74", "url": "https://omabrowser.org/oma/group/E1BC74/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CZ52-1", "protein_name": "Anthrax toxin receptor 1", "gene_name": "Antxr1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDRAGRLGAGLRGLCVAALVLVCAGHGGRREDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHRFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENSQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFAVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLVLFLLLALALLWWFWPLCCTVIIKEVPPPPVEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGRCINFTRVKNSQPAKYPLNNTYHPSSPPPAPIYTPPPPAPHCPPPAPSAPTPPIPSPPSTLPPPPQAPPPNRAPPPSRPPPRPSV", "length": 562 }, "evidence": [ { "id": "E1BC74", "url": "https://omabrowser.org/oma/group/E1BC74/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H6X2-1", "protein_name": "Anthrax toxin receptor 1", "gene_name": "ANTXR1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATAERRALGIGFQWLSLATLVLICAGQGGRREDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPPAEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGRCINFTRVKNNQPAKYPLNNAYHTSSPPPAPIYTPPPPAPHCPPPPPSAPTPPIPSPPSTLPPPPQAPPPNRAPPPSRPPPRPSV", "length": 564 }, "evidence": [ { "id": "E1BC74", "url": "https://omabrowser.org/oma/group/E1BC74/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "transmembrane signaling receptor activity", "id": "GO:0004888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "evidence": [ { "database": "UniProtKB", "id": "E1BC74", "url": "https://www.uniprot.org/uniprotkb/E1BC74" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BC74", "url": "https://www.uniprot.org/uniprotkb/E1BC74" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "E1BC74", "url": "https://www.uniprot.org/uniprotkb/E1BC74" } ], "pmid": "" }, { "name": "collagen binding", "id": "GO:0005518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005518", "evidence": [ { "database": "UniProtKB", "id": "E1BC74", "url": "https://www.uniprot.org/uniprotkb/E1BC74" } ], "pmid": "" }, { "name": "signaling receptor activity", "id": "GO:0038023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "database": "UniProtKB", "id": "E1BC74", "url": "https://www.uniprot.org/uniprotkb/E1BC74" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BC74", "url": "https://www.uniprot.org/uniprotkb/E1BC74" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "E1BC74", "url": "https://www.uniprot.org/uniprotkb/E1BC74" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "E1BC74", "url": "https://www.uniprot.org/uniprotkb/E1BC74" } ], "pmid": "" }, { "name": "lamellipodium membrane", "id": "GO:0031258", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031258", "evidence": [ { "database": "UniProtKB", "id": "E1BC74", "url": "https://www.uniprot.org/uniprotkb/E1BC74" } ], "pmid": "" }, { "name": "filopodium membrane", "id": "GO:0031527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031527", "evidence": [ { "database": "UniProtKB", "id": "E1BC74", "url": "https://www.uniprot.org/uniprotkb/E1BC74" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "E1BC74", "url": "https://www.uniprot.org/uniprotkb/E1BC74" } ], "pmid": "" }, { "name": "substrate adhesion-dependent cell spreading", "id": "GO:0034446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034446", "evidence": [ { "database": "UniProtKB", "id": "E1BC74", "url": "https://www.uniprot.org/uniprotkb/E1BC74" } ], "pmid": "" }, { "name": "positive regulation of epidermal growth factor receptor signaling pathway", "id": "GO:0045742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045742", "evidence": [ { "database": "UniProtKB", "id": "E1BC74", "url": "https://www.uniprot.org/uniprotkb/E1BC74" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 262, "end_pos": 264, "annotation": "n_glycosylation_sequon" }, { "start_pos": 494, "end_pos": 496, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BC74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC74" }, { "id": "PS50234", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50234" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFA", "eco_id": "ECO_0000259", "start_pos": 44, "end_pos": 215, "start_aa": "Asp", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "A0A3Q1MVZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVZ0#function" }, { "id": "A0A3Q1MVZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVZ0" }, { "id": "PIRSR038023-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038023-1" } ], "binding_site_uniprot": 118, "amino_acid": "Thr", "chebi_lig_id": "CHEBI_60240", "ligand": "divalent metal cation", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 118, "end_pos": 118, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1MVZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVZ0#function" }, { "id": "A0A3Q1MVZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVZ0" }, { "id": "PIRSR038023-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038023-1" } ], "binding_site_uniprot": 52, "amino_acid": "Ser", "chebi_lig_id": "CHEBI_60240", "ligand": "divalent metal cation", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 52, "end_pos": 52, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1MVZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVZ0#function" }, { "id": "A0A3Q1MVZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVZ0" }, { "id": "PIRSR038023-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038023-1" } ], "binding_site_uniprot": 54, "amino_acid": "Ser", "chebi_lig_id": "CHEBI_60240", "ligand": "divalent metal cation", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 54, "end_pos": 54, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 166, "end_pos": 168 }, { "start_pos": 184, "end_pos": 186 }, { "start_pos": 262, "end_pos": 264 }, { "start_pos": 494, "end_pos": 496 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A7E371-1", "uniprot_ac": "A7E371", "uniprot_id": "PRCA1_BOVIN", "mass": { "chemical_mass": 42242.0, "monoisotopic_mass": 42242.0 }, "refseq": { "ac": "NP_001160040", "name": "protein PROCA1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160040" }, "gene_names": [ { "name": "PROCA1", "type": "recommended", "evidence": [ { "id": "A7E371", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E371" } ] }, { "name": "PROCA1", "type": "synonym", "evidence": [ { "id": "NP_001160040", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160040" } ] } ], "protein_names": [ { "name": "Protein PROCA1", "type": "recommended", "evidence": [ { "id": "A7E371", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E371/entry#names_and_taxonomy" } ] }, { "name": "proline-rich cyclin A1-interacting protein", "type": "synonym", "evidence": [ { "id": "NP_001160040", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160040" } ] }, { "name": "protein PROCA1", "type": "synonym", "evidence": [ { "id": "NP_001160040", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160040" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7E371", "url": "https://www.uniprot.org/uniprotkb/A7E371" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PROCA1", "url": "https://www.uniprot.org/uniprotkb/A7E371", "locus": { "chromosome": "19", "start_pos": 20130801, "end_pos": 20138349, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017268", "url": "https://www.ensembl.org/id/ENSBTAG00000017268" } ] } } ], "crossref": [ { "id": "A7E371", "url": "https://alphafold.ebi.ac.uk/entry/A7E371", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017268", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017268", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04705", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04705", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510175", "url": "https://www.ncbi.nlm.nih.gov/gene/510175", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016090", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016090", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036444", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036444", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510175", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510175", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IHPFSDC", "url": "https://omabrowser.org/oma/group/IHPFSDC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LFY3", "url": "https://www.orthodb.org/?gene=A0A3Q1LFY3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A7E371", "url": "https://www.orthodb.org/?gene=A7E371", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12253", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12253", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05826", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05826", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001160040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160040", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LFY3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LFY3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFY3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHG4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHG4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHG4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHR5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHR5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8Y7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Y7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8Y7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Y7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZGI7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZGI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7E371", "url": "https://www.uniprot.org/uniprotkb/A7E371", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7E371-1", "url": "https://www.uniprot.org/uniprotkb/A7E371-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWVRTTLRIERWTKEKTEDDTSSWDESSTDINRLPSWGRGHLLASVESSTDASTLSSEGEFKNTDRCCWKHKCAGHIVRPFSPDCVHHDVHLHSLSHCDCDSRLKDCSEKTNSSSGDVGPTCSRDVDSTCFDIIQSPCFELIPEEECVERFWYGWCKSYRPVSVAVIHHPIHHECGADDLNQEEEEEEEEESKPPIPTQVGPTPTDSPTDTGMSMITGAPDSAAPITIWRSESPTGKSQGNRVIKKIKKKKEKDKEEETDEKEKAKVKKKVKKGKLMKKKSPVKSESPPDLSRSLSPRELARMSESSPDSRQDLESEDSYNDPGREEPSSEDIVESSSPRKREKNGVQVKKPGLKTSPVKKINKRRSPPASNPNLS", "length": 376, "header": "sp|A7E371-1|PRCA1_BOVIN Isoform 1 of Protein PROCA1 OS=Bos taurus OX=9913 GN=PROCA1 PE=2 SV=2 CANONICAL=A7E371-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LFY3-1", "url": "https://www.uniprot.org/uniprotkb/A7E371/entry#A0A3Q1LFY3-1", "sequence": { "sequence": "MRAARGRKKSGSSTSDVTIASRDINRLPSWGRGHLLASVESSTDASTLSSEGEFKNTDRCCWKHKCAGHIVRPFSPDCVHHDVHLHSLSHCDCDSRLKDCSEKTNSSSGDVGPTCSRDVDSTCFDIIQSPCFELIPEEECVERFWYGWCKSYRPVSVAVIHHPIHHECGADDLNQEEEEEEEEESKPPIPTQVGPTPTDSPTDTGMSMITGAPDSAAPITIWRSESPTGKSQGNRVIKKIKKKKEKDKEEETDEKEKAKVKKKVKKGKLMKKKSPVKSESPPDLSRSLSPRELARMSESSPDSRQDLESEDSYNDPGREEPSSEDIVESSSPRKREKNGVQVKKPGLKTSPVKKINKRRSPPASNPNLS", "length": 369, "header": "tr|A0A3Q1LFY3-1|PRCA1_BOVIN Computationally mapped isoform of Protein PROCA1 OS=Bos taurus OX=9913 GN=PROCA1 PE=2 SV=2 CANONICAL=A7E371-1" }, "locus": { "chromosome": "19", "start_pos": 20137906, "end_pos": 20131151, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070400.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070400.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057197.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057197.2" } ] } }, { "isoform_ac": "A0AAA9SHG4-1", "url": "https://www.uniprot.org/uniprotkb/A7E371/entry#A0AAA9SHG4-1", "sequence": { "sequence": "LPLPSFPSLIFPSLPSSFPPPYLPPPFSCSGARPGTLTPVPQGQGELLSSQDWADCTNEHHLPCGEQGLLSFKGCISWGLSLELLRSRFLSEWSGEGLLLPLCTLSDINRLPSWGRGHLLASVESSTDASTLSSEGEFKNTDRCCWKHKCAGHIVRPFSPDCVHHDVHLHSLSHCDCDSRLKDCSEKTNSSSGDVGPTCSRDVDSTCFDIIQSPCFELIPEEECVERFWYGWCKSYRPVSVAVIHHPIHHECGADDLNQEEEEEEEEESKPPIPTQVGPTPTDSPTDTGMSMITGAPDSAAPITIWRSESPTGKSQGNRVIKKIKKKKEKDKEEETDEKEKAKVKKKVKKGKLMKKKSPVKSESPPDLSRSLSPRELARMSESSPDSRQDLESEDSYNDPGREEPSSEDIVESSSPRKREKNGVQVKKPGLKTSPVKKINKRRSPPASNPNLS", "length": 453, "header": "tr|A0AAA9SHG4-1|PRCA1_BOVIN Computationally mapped isoform of Protein PROCA1 OS=Bos taurus OX=9913 GN=PROCA1 PE=2 SV=1 CANONICAL=A7E371-1" }, "locus": { "chromosome": "19", "start_pos": 20137434, "end_pos": 20131151, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121275.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121275.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084787.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084787.1" } ] } }, { "isoform_ac": "A0AAA9SHR5-1", "url": "https://www.uniprot.org/uniprotkb/A7E371/entry#A0AAA9SHR5-1", "sequence": { "sequence": "SGFKGWEGRDIGLPSGPVLSGTKDATGSPRPSTPRVTLRTRGEFKNTDRCCWKHKCAGHIVRPFSPDCVHHDVHLHSLSHCDCDSRLKDCSEKTNSSSGDVGPTCSRDVDSTCFDIIQSPCFELIPEEECVERFWYGWCKSYRPVSVAVIHHPIHHECGADDLNQEEEEEEEEESKPPIPTQVGPTPTDSPTDTGMSMITGAPDSAAPITIWRSESPTGKSQGNRVIKKIKKKKEKDKEEETDEKEKAKVKKKVKKGKLMKKKSPVKSESPPDLSRSLSPRELARMSESSPDSRQDLESEDSYNDPGREEPSSEDIVESSSPRKREKNGVQVKKPGLKTSPVKKINKRRSPPASNPNLS", "length": 359, "header": "tr|A0AAA9SHR5-1|PRCA1_BOVIN Computationally mapped isoform of Protein PROCA1 OS=Bos taurus OX=9913 GN=PROCA1 PE=2 SV=1 CANONICAL=A7E371-1" }, "locus": { "chromosome": "19", "start_pos": 20133144, "end_pos": 20131151, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100174.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100174.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084885.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084885.1" } ] } }, { "isoform_ac": "A0AAA9T8Y7-1", "url": "https://www.uniprot.org/uniprotkb/A7E371/entry#A0AAA9T8Y7-1", "sequence": { "sequence": "MWVRTTLRIERWTKEKTEDDTSSWDESSTGEFKNTDRCCWKHKCAGHIVRPFSPDCVHHDVHLHSLSHCDCDSRLKDCSEKTNSSSGDVGPTCSRDVDSTCFDIIQSPCFELIPEEECVERFWYGWCKSYRPVSVAVIHHPIHHECGADDLNQEEEEEEEEESKPPIPTQVGPTPTDSPTDTGMSMITGAPDSAAPITIWRSESPTGKSQGNRVIKKIKKKKEKDKEEETDEKEKAKVKKKVKKGKLMKKKSPVKSESPPDLSRSLSPRELARMSESSPDSRQDLESEDSYNDPGREEPSSEDIVESSSPRKREKNGVQVKKPGLKTSPVKKINKRRSPPASNPNLS", "length": 347, "header": "tr|A0AAA9T8Y7-1|PRCA1_BOVIN Computationally mapped isoform of Protein PROCA1 OS=Bos taurus OX=9913 GN=PROCA1 PE=2 SV=1 CANONICAL=A7E371-1" }, "locus": { "chromosome": "19", "start_pos": 20137979, "end_pos": 20131151, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092914.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092914.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092357.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092357.1" } ] } }, { "isoform_ac": "A0AAF6ZGI7-1", "url": "https://www.uniprot.org/uniprotkb/A7E371/entry#A0AAF6ZGI7-1", "sequence": { "sequence": "EQHGCSGARPGTLTPVPQGQGELLSSQDWADCTNEHHLPCGEQGLLSFKGCISWGLSLELLRSRFLSEWSGEGLLLPLCTLSDINRLPSWGRGHLLASVESSTDASTLSSEGEFKNTDRCCWKHKCAGHIVRPFSPDCVHHDVHLHSLSHCDCDSRLKDCSEKTNSSSGDVGPTCSRDVDSTCFDIIQSPCFELIPEEECVERFWYGWCKSYRPVSVAVIHHPIHHECGADDLNQEEEEEEEEESKPPIPTQVGPTPTDSPTDTGMSMITGAPDSAAPITIWRSESPTGKSQGNRVIKKIKKKKEKDKEEETDEKEKAKVKKKVKKGKLMKKKSPVKSESPPDLSRSLSPRELARMSESSPDSRQDLESEDSYNDPGREEPSSEDIVESSSPRKREKNGVQVKKPGLKTSPVKKINKRRSPPASNPNLS", "length": 429, "header": "tr|A0AAF6ZGI7-1|PRCA1_BOVIN Computationally mapped isoform of Protein PROCA1 OS=Bos taurus OX=9913 GN=PROCA1 PE=2 SV=1 CANONICAL=A7E371-1" }, "locus": { "chromosome": "19", "start_pos": 20137902, "end_pos": 20131151, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047094.5", "url": "https://www.ensembl.org/id/ENSBTAT00000047094.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044327.4", "url": "https://www.ensembl.org/id/ENSBTAP00000044327.4" } ] } }, { "isoform_ac": "A7E371-1", "url": "https://www.uniprot.org/uniprotkb/A7E371/entry#A7E371-1", "sequence": { "sequence": "MWVRTTLRIERWTKEKTEDDTSSWDESSTDINRLPSWGRGHLLASVESSTDASTLSSEGEFKNTDRCCWKHKCAGHIVRPFSPDCVHHDVHLHSLSHCDCDSRLKDCSEKTNSSSGDVGPTCSRDVDSTCFDIIQSPCFELIPEEECVERFWYGWCKSYRPVSVAVIHHPIHHECGADDLNQEEEEEEEEESKPPIPTQVGPTPTDSPTDTGMSMITGAPDSAAPITIWRSESPTGKSQGNRVIKKIKKKKEKDKEEETDEKEKAKVKKKVKKGKLMKKKSPVKSESPPDLSRSLSPRELARMSESSPDSRQDLESEDSYNDPGREEPSSEDIVESSSPRKREKNGVQVKKPGLKTSPVKKINKRRSPPASNPNLS", "length": 376, "header": "sp|A7E371-1|PRCA1_BOVIN Isoform 1 of Protein PROCA1 OS=Bos taurus OX=9913 GN=PROCA1 PE=2 SV=2 CANONICAL=A7E371-1" }, "locus": { "chromosome": "19", "start_pos": 20137979, "end_pos": 20131151, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113068.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113068.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091875.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091875.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 121, "start_aa": "Thr", "end_pos": 121, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr121", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 203, "start_aa": "Thr", "end_pos": 203, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr203", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 205, "start_aa": "Thr", "end_pos": 205, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr205", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 319, "end_pos": 319, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7E371", "url": 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"url": "https://www.uniprot.org/uniprotkb/A0AAA9TQY8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUB4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDP9", "url": "https://www.uniprot.org/uniprotkb/E1BDP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDP9-1", "url": "https://www.uniprot.org/uniprotkb/E1BDP9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEALLEGIQNRGHDGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDIRERELKALRSQLDLKHKEIGMLRQQVEKHEKVKQEMAMEYKQELKKLHEELSRLKRSYEKLQKKHVRDFRGNAKNHREDRSEIERLTGKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLANRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTNMTIMQEQRQKEEKLKESEKMLEVLQEEKRGLKAALQTQENFIHDARIQKEKLQAKLKAVDTQHTVETIRSLEEPLAERRYASQGQGDLQNVLCQLDFTHTSEELLQAEVTRLEGSLESVSATCKQLSQELMEKYGELKKMEVHNNEYRAEIKKLKEQILQAEQSYSSVLEGMKMEISQLTRELHQRDITIASTKSSSSDMEKRLKAEIQKAEEKAVEHKEMLGQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMDTKGQLEISTQICKKNRDRIFKPTYSRVPEFKNTEFKPAHGQHRHDGMKAEPYKAGLHSPQGQASDSIEPVSLSRGFSPPSHQISSCCSTVSLPSNFLCKTNSLPSVLDTNETNFSDTVSESINDPEDFTSSCPLPLSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVKQFTVLK", "length": 705, "header": "tr|E1BDP9-1|E1BDP9_BOVIN Isoform 1 of Centrosomal protein of 63 kDa OS=Bos taurus OX=9913 GN=CEP63 PE=3 SV=2 CANONICAL=E1BDP9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LI85-1", "url": "https://www.uniprot.org/uniprotkb/E1BDP9/entry#A0A3Q1LI85-1", "sequence": { "sequence": "MEALLEGIQNRGHDGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDIRERELKALRSQLDLKHKEIGMLRQQVEKHEKVKQEMAMEYKQELKKLHEELSRLKRSYEKLQKKHVRDFRGNAKNHREDRSEIERLTGKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLANRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTNMTIMQEQRQKEEKLKESEKMLEVLQEEKRGLKAALQTQENFIHDARIQKEKLQAKLKAVDTQHTVETISLESVSATCKQLSQELMEKYGELKKMEVHNNEYRAEIKKLKEQILQAEQSYSSVLEGMKMEISQLTRELHQRDITIASTKSSSSDMEKRLKAEIQKAEEKAVEHKEMLGQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMDTKGQLEISTQICKKNRDRIFKPTYSRVPEFKNTEFKPAHGQHRHDGMKAEPYKAGLHSPQGQASDSIEPVSLSRGFSPPSHQISSCCSTVSLPSNFLCKTNSLPSVLDTNETNFSDTVSESINDPEDFTSSCPLPLSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVKQFTVLK", "length": 659, "header": "tr|A0A3Q1LI85-1|E1BDP9_BOVIN Computationally mapped isoform of Centrosomal protein of 63 kDa OS=Bos taurus OX=9913 GN=CEP63 PE=3 SV=2 CANONICAL=E1BDP9-1" }, "locus": { "chromosome": "1", "start_pos": 134828694, "end_pos": 134765526, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085483.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085483.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058672.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058672.2" } ] } }, { "isoform_ac": "A0A3Q1LY95-1", "url": "https://www.uniprot.org/uniprotkb/E1BDP9/entry#A0A3Q1LY95-1", "sequence": { "sequence": "MASLTHWICQNKGDLAMEALLEGIQNRGHDGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDIRERELKALRSQLDLKHKEIGMLRQQVEKHEKVKQEMAMEYKQELKKLHEELSRLKRSYEKLQKKHVRDFRGNAKNHREDRSEIERLTGKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLANRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTNMTIMQEQRQKEEKLKESEKMLEVLQEEKRGLKAALQTQENFIHDARIQKEKLQAKLKAVDTQHTVETIRSLEEPLAERRYASQGQGDLQNVLCQLDFTHTSEELLQAEVTRLEGSLESVSATCKQLSQELMEKYGELKKMEVHNNEYRAEIKKLKEQILQAEQSYSSVLEGMKMEISQLTRELHQRDITIASTKSSSSDMEKRLKAEIQKAEEKAVEHKEMLGQLESLKLENRHLSEMVMKLELGLHECPLPLSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVKQFTVLK", "length": 557, "header": "tr|A0A3Q1LY95-1|E1BDP9_BOVIN Computationally mapped isoform of Centrosomal protein of 63 kDa OS=Bos taurus OX=9913 GN=CEP63 PE=3 SV=2 CANONICAL=E1BDP9-1" }, "locus": { "chromosome": "1", "start_pos": 134837272, "end_pos": 134765526, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085657.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085657.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065718.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065718.2" } ] } }, { "isoform_ac": "A0A3Q1LZS7-1", "url": "https://www.uniprot.org/uniprotkb/E1BDP9/entry#A0A3Q1LZS7-1", "sequence": { "sequence": "MEALLEGIQNRGHDGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDIRERELKALRSQLDLKHKEIGMLRQQVEKHEKVKQEMAMEYKQELKKLHEELSRLKRSYEKLQKKHVRDFRGNAKNHREDRSEIERLTGKIEAQLANRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTNMTIMQEQRQKEEKLKESEKMLEVLQEEKRGLKAALQTQENFIHDARIQKEKLQAKLKAVDTQHTVETIRSLEEPLAERRYASQGQGDLQNVLCQLDFTHTSEELLQAEVTRLEGSLESVSATCKQLSQELMEKYGELKKMEVHNNEYRAEIKKLKEQILQAEQSYSSVLEGMKMEISQLTRELHQRDITIASTKSSSSDMEKRLKAEIQKAEEKAVEHKEMLGQLESLKLENRHLSEMVMKLELGLHECPLPLSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVKQFTVLK", "length": 503, "header": "tr|A0A3Q1LZS7-1|E1BDP9_BOVIN Computationally mapped isoform of Centrosomal protein of 63 kDa OS=Bos taurus OX=9913 GN=CEP63 PE=3 SV=1 CANONICAL=E1BDP9-1" }, "locus": { "chromosome": "1", "start_pos": 134828694, "end_pos": 134765526, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071587.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071587.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062848.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062848.1" } ] } }, { "isoform_ac": "A0A3Q1M7U9-1", "url": "https://www.uniprot.org/uniprotkb/E1BDP9/entry#A0A3Q1M7U9-1", "sequence": { "sequence": "MTNSWSLPKPMSVVCQNKGDLAMEALLEGIQNRGHDGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDIRERELKALRSQLDLKHKEIGMLRQQVEKHEKVKQEMAMEYKQELKKLHEELSRLKRSYEKLQKKHVRDFRGNAKNHREDRSEIERLTGKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLANRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTNMTIMQEQRQKEEKLKESEKMLEVLQEEKRGLKAALQTQENFIHDARIQKEKLQAKLKAVDTQHTVETIRSLEEPLAERRYASQGQGDLQNVLCQLDFTHTSEELLQAEVTRLEGSLESVSATCKQLSQELMEKYGELKKMEVHNNEYRAEIKKLKEQILQAEQSYSSVLEGMKMEISQLTRELHQRDITIASTKSSSSDMEKRLKAEIQKAEEKAVEHKEMLGQLESLKLENRHLSEMVMKLELGLHECPLPLSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVKQFTVLK", "length": 563, "header": "tr|A0A3Q1M7U9-1|E1BDP9_BOVIN Computationally mapped isoform of Centrosomal protein of 63 kDa OS=Bos taurus OX=9913 GN=CEP63 PE=3 SV=2 CANONICAL=E1BDP9-1" }, "locus": { "chromosome": "1", "start_pos": 134830684, "end_pos": 134765526, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074965.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074965.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066479.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066479.2" } ] } }, { "isoform_ac": "A0AAA9SDX0-1", "url": "https://www.uniprot.org/uniprotkb/E1BDP9/entry#A0AAA9SDX0-1", "sequence": { "sequence": "MLGKIEGRKRRGQWKRMRWLDGITDSLDSTVMSWWPSNLQSCQNKGDLAMEALLEGIQNRGHDGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDIRERELKALRSQLDLKHKEIGMLRQQVEKHEKVKQEMAMEYKQELKKLHEELSRLKRSYEKLQKKHVRDFRGNAKNHREDRSEIERLTGKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLANRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTNMTIMQEQRQKEEKLKESEKMLEVLQEEKRGLKAALQTQENFIHDARIQKEKLQAKLKAVDTQHTVETIRSLEEPLAERRYASQGQGDLQNVLCQLDFTHTSEELLQAEVTRLEGSLESVSATCKQLSQELMEKYGELKKMEVHNNEYRAEIKKLKEQILQAEQSYSSVLEGMKMEISQLTRELHQRDITIASTKSSSSDMEKRLKAEIQKAEEKAVEHKEMLGQLESLKLENRHLSEMVMKLELGLHECPLPLSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVKQFTVLK", "length": 590, "header": "tr|A0AAA9SDX0-1|E1BDP9_BOVIN Computationally mapped isoform of Centrosomal protein of 63 kDa OS=Bos taurus OX=9913 GN=CEP63 PE=3 SV=1 CANONICAL=E1BDP9-1" }, "locus": { "chromosome": "1", "start_pos": 134837333, "end_pos": 134765526, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120028.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120028.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084333.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084333.1" } ] } }, { "isoform_ac": "A0AAA9TBB9-1", "url": "https://www.uniprot.org/uniprotkb/E1BDP9/entry#A0AAA9TBB9-1", "sequence": { "sequence": "MSWWPSNLQSCQNKGDLAMEALLEGIQNRGHDGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDIRERELKALRSQLDLKHKEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLANRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTNMTIMQEQRQKEEKLKESEKMLEVLQEEKRGLKAALQTQENFIHDARIQKEKLQAKLKAVDTQHTVETISLESVSATCKQLSQELMEKYGELKKMEVHNNEYRAEIKKLKEQILQAEQSYSSVLEGMKMEISQLTRELHQRDITIASTKSSSSDMEKRLKAEIQKAEEKAVEHKEMLGQLESLKLENRHLSEMVMKLELGLHECPLPLSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVKQFTVLK", "length": 440, "header": "tr|A0AAA9TBB9-1|E1BDP9_BOVIN Computationally mapped isoform of Centrosomal protein of 63 kDa OS=Bos taurus OX=9913 GN=CEP63 PE=3 SV=1 CANONICAL=E1BDP9-1" }, "locus": { "chromosome": "1", "start_pos": 134835927, "end_pos": 134765526, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090637.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090637.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096012.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096012.1" } ] } }, { "isoform_ac": "A0AAA9TQY8-1", "url": "https://www.uniprot.org/uniprotkb/E1BDP9/entry#A0AAA9TQY8-1", "sequence": { "sequence": "MSWWPSNLQSCQNKGDLAMEALLEGIQNRGHDGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDIRERELKALRSQLDLKHKEIGMLRQQVEKHEKVKQEMAMEYKQELKKLHEELSRLKRSYEKLQKKHVRDFRGNAKNHREDRSEIERLTGKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLANRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTNMTIMQEQRQKEEKLKESEKMLEVLQEEKRGLKAALQTQENFIHDARIQKEKLQAKLKAVDTQHTVETIRSLEEPLAERRYASQGQGDLQNVLCQLDFTHTSEELLQAEVTRLEGSLESVSATCKQLSQELMEKYGELKKMEVHNNEYRAEIKKLKEQILQAEQSYSSVLEGMKMEISQLTRELHQRDITIASTKSSSSDMEKRLKAEIQKAEEKAVEHKEMLGQLESLKLENRHLSEMVMKLELGLHECPLPLSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVKQFTVLK", "length": 559, "header": "tr|A0AAA9TQY8-1|E1BDP9_BOVIN Computationally mapped isoform of Centrosomal protein of 63 kDa OS=Bos taurus OX=9913 GN=CEP63 PE=3 SV=1 CANONICAL=E1BDP9-1" }, "locus": { "chromosome": "1", "start_pos": 134835927, "end_pos": 134765526, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112667.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112667.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101000.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101000.1" } ] } }, { "isoform_ac": "A0AAA9TS65-1", "url": "https://www.uniprot.org/uniprotkb/E1BDP9/entry#A0AAA9TS65-1", "sequence": { "sequence": "MCESPTGDGCPCPEPEAALAAVGPQTERPNGRGPTSSATRWPPGLPPPARLRPGAPPLLSANASQTREARYGLSRRAVRASQSTVMSWWPSNLQSCQNKGDLAMEALLEGIQNRGHDGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDIRERELKALRSQLDLKHKEIGMLRQQVEKHEKVKQEMAMEYKQELKKLHEELSRLKRSYEKLQKKHVRDFRGNAKNHREDRSEIERLTGKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLANRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTNMTIMQEQRQKEEKLKESEKMLEVLQEEKRGLKAALQTQENFIHDARIQKEKLQAKLKAVDTQHTVETIRSLEEPLAERRYASQGQGDLQNVLCQLDFTHTSEELLQAEVTRLEGSLESVSATCKQLSQELMEKYGELKKMEVHNNEYRAEIKKLKEQILQAEQSYSSVLEGMKMEISQLTRELHQRDITIASTKSSSSDMEKRLKAEIQKAEEKAVEHKEMLGQLESLKLENRHLSEMVMKLELGLHECPLPLSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVKQFTVLK", "length": 644, "header": "tr|A0AAA9TS65-1|E1BDP9_BOVIN Computationally mapped isoform of Centrosomal protein of 63 kDa OS=Bos taurus OX=9913 GN=CEP63 PE=3 SV=1 CANONICAL=E1BDP9-1" }, "locus": { "chromosome": "1", "start_pos": 134838857, "end_pos": 134765526, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090451.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090451.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099879.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099879.1" } ] } }, { "isoform_ac": "A0AAA9TUB4-1", "url": "https://www.uniprot.org/uniprotkb/E1BDP9/entry#A0AAA9TUB4-1", "sequence": { "sequence": "MSWWPSNLQSCQNKGDLAMEALLEGIQNRGHDGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDIRERELKALRSQLDLKHKEIGMLRQQVEKHEKVKQEMAMEYKQELKKLHEEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLANRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTNMTIMQEQRQKEEKLKESEKMLEVLQEEKRGLKAALQTQENFIHDARIQKEKLQAKLKAVDTQHTVETIRSLEEPLAERRYASQGQGDLQNVLCQLDFTHTSEELLQAEVTRLEGSLESVSATCKQLSQELMEKYGELKKMEVHNNEYRAEIKKLKEQILQAEQSYSSVLEGMKMEISQLTRELHQRDITIASTKSSSSDMEKRLKAEIQKAEEKAVEHKEMLGQLESLKLENRHLSEMVMKLELGLHECPLPLSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVKQFTVLK", "length": 518, "header": "tr|A0AAA9TUB4-1|E1BDP9_BOVIN Computationally mapped isoform of Centrosomal protein of 63 kDa OS=Bos taurus OX=9913 GN=CEP63 PE=3 SV=1 CANONICAL=E1BDP9-1" }, "locus": { "chromosome": "1", "start_pos": 134835927, "end_pos": 134765526, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107436.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107436.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102200.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102200.1" } ] } }, { "isoform_ac": "E1BDP9-1", "url": "https://www.uniprot.org/uniprotkb/E1BDP9/entry#E1BDP9-1", "sequence": { "sequence": "MEALLEGIQNRGHDGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDIRERELKALRSQLDLKHKEIGMLRQQVEKHEKVKQEMAMEYKQELKKLHEELSRLKRSYEKLQKKHVRDFRGNAKNHREDRSEIERLTGKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLANRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTNMTIMQEQRQKEEKLKESEKMLEVLQEEKRGLKAALQTQENFIHDARIQKEKLQAKLKAVDTQHTVETIRSLEEPLAERRYASQGQGDLQNVLCQLDFTHTSEELLQAEVTRLEGSLESVSATCKQLSQELMEKYGELKKMEVHNNEYRAEIKKLKEQILQAEQSYSSVLEGMKMEISQLTRELHQRDITIASTKSSSSDMEKRLKAEIQKAEEKAVEHKEMLGQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMDTKGQLEISTQICKKNRDRIFKPTYSRVPEFKNTEFKPAHGQHRHDGMKAEPYKAGLHSPQGQASDSIEPVSLSRGFSPPSHQISSCCSTVSLPSNFLCKTNSLPSVLDTNETNFSDTVSESINDPEDFTSSCPLPLSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVKQFTVLK", "length": 705, "header": "tr|E1BDP9-1|E1BDP9_BOVIN Isoform 1 of Centrosomal protein of 63 kDa OS=Bos taurus OX=9913 GN=CEP63 PE=3 SV=2 CANONICAL=E1BDP9-1" }, "locus": { "chromosome": "1", "start_pos": 134828694, "end_pos": 134765526, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009235.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009235.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009235.6", "url": "https://www.ensembl.org/id/ENSBTAP00000009235.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-2565942", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2565942", "resource": "Reactome", "description": "Regulation of PLK1 Activity at G2/M Transition" }, { "id": "R-BTA-380259", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380259", "resource": "Reactome", "description": "Loss of Nlp from mitotic centrosomes" }, { "id": "R-BTA-380270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "resource": "Reactome", "description": "Recruitment of mitotic centrosome proteins and complexes" }, { "id": "R-BTA-380284", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380284", "resource": "Reactome", "description": "Loss of proteins required for interphase microtubule organization from the centrosome" }, { "id": "R-BTA-380320", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "resource": "Reactome", "description": "Recruitment of NuMA to mitotic centrosomes" }, { "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" }, { "id": "R-BTA-8854518", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "resource": "Reactome", "description": "AURKA Activation by TPX2" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1TTT3-1", "protein_name": "Centrosomal protein of 63 kDa", "gene_name": "CEP63", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEALLEGIQNRGHEGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDVRERELKALRSQLDMKHKEVGMLRQQVEEHEKVKQEMAMEYKQELKKLHEELGRLKRSYEKLQKKHVRDFRGNTKNHREDRSEIERLTGKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKTLAEQSEIIQAQLANRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTNMTIMQEQRQKEEKLRESDKLLEVLQEEKRELKAALQTQENFIREARIQKEKLQAKLKAADTQHTLETMRSLEEAQEERGYPSQGQGDLEKVLSRLDFTHTSEELLQAEVTHLEGSLESVSATCKQLSQELMEKYEELKKMEVHNNEYRAEIKKLKEQILQAEQSYSSVLEGMKMEISQLTRELHQRDITIASTKSSSSDMERRLKVEIQKAEEKAVEHKEILNQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMDTKSQLEISTQMCKKNHDRIFKPTHSRIPVFKPAHGQHRQDGMQTEHYKAGLHSPRGQASDSIEPLSRGLSPARSQISPCCSTMSLPSNFLSKTHSLPSVLDTNETNFSDTISESINDQEDFISSCPLPLSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVKQFTAQK", "length": 698 }, "evidence": [ { "id": "E1BDP9", "url": "https://omabrowser.org/oma/group/E1BDP9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3UPP8-1", "protein_name": "Centrosomal protein of 63 kDa", "gene_name": "Cep63", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEALLEGIQNRGHSGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDIRDRELKALRSQLDMKHKEVGILHQQIEEHEKTKQEMAMEYKEELLKLQEELSRLKRSYEKLQKKQLREFRGNTKSFREDRSEIERLTGKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLANRKQKLESVELSSQSEIQHLNSKLERAKDTICANELEIERLNIRVNDLMGTNMTILQDHRQKEEKLRESEKLLEALQEEQKELKASLQSQETFILEAKMQEKLQTTLKAVGTQQSVERPLEDCQKERKYSSPGQGVLDNVLSQLDFSHSSEELLQAEVTRLEGSLESVSATCKQLSQELMEKYEELKRMEGHNNEYRTEIKKLKEQILQADQTYSSALEGMKMEISQLTRELHQRDITIASAKCSSSDMEKQLKAEMQKAEEKAVEHKEILSQLESLKLENHRLSETVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMSTKSELEHATNMCKKKDGEIFNPAHSRAAGFKNAELKPIHGQHRHDGIKTEQYKTGHHSPRGQTLDSIDPVARGPSPLSSHISPGSSTVSLPSNFLFEAHSLPSVLDINDVNFSDSLSDCMNDQEEFVSSGSLPTSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALV", "length": 700 }, "evidence": [ { "id": "E1BDP9", "url": "https://omabrowser.org/oma/group/E1BDP9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q4KLY0-1", "protein_name": "Centrosomal protein of 63 kDa", "gene_name": "Cep63", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEALLEGIQTRGHSGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDMRDRELKALRSQLDMKHKEVGILHQQIEEQEKTKQEMALEYKEELMKLQEELSRLKRSYEKLQKKQLREFRGNTKSLREDRSEIERLTGKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLANRKQKLESVELSSQSEIQHLSSKLERAKDTICANELEIERLNIRVKDLMGTNVTILQEQRQKEEKLRESEKLLEALQEEQKELKASLQAQESFILDAKMQEKLQTKLKAVDTKHSVERSLEDCQVERKYSSSGQGVLDNVLSQLDISHSSEELLQAEVTRLEGSLESVSTTCKQLSQELMEKYEELKRMEGHNNEYRTEIKKLKEQILQADQTYSSALEGMKTEISQLTRELHQRDITIASAKCSSSDMERQLKAEMQKAEEKAVEHKEILSQLESLRLENRRLSETVMKLELGLHECSMPVSPLGLIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALV", "length": 538 }, "evidence": [ { "id": "E1BDP9", "url": "https://omabrowser.org/oma/group/E1BDP9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96MT8-1", "protein_name": "Centrosomal protein of 63 kDa", "gene_name": "CEP63", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALK", "length": 703 }, "evidence": [ { "id": "E1BDP9", "url": "https://omabrowser.org/oma/group/E1BDP9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "E1BDP9", "url": "https://www.uniprot.org/uniprotkb/E1BDP9" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "E1BDP9", "url": "https://www.uniprot.org/uniprotkb/E1BDP9" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "E1BDP9", "url": "https://www.uniprot.org/uniprotkb/E1BDP9" } ], "pmid": "" }, { "name": "negative regulation of innate immune response", "id": "GO:0045824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045824", "evidence": [ { "database": "UniProtKB", "id": "E1BDP9", "url": "https://www.uniprot.org/uniprotkb/E1BDP9" } ], "pmid": "" }, { "name": "centriole replication", "id": "GO:0007099", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007099", "evidence": [ { "database": "UniProtKB", "id": "E1BDP9", "url": "https://www.uniprot.org/uniprotkb/E1BDP9" } ], "pmid": "" }, { "name": "de novo centriole assembly involved in multi-ciliated epithelial cell differentiation", "id": "GO:0098535", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098535", "evidence": [ { "database": "UniProtKB", "id": "E1BDP9", "url": "https://www.uniprot.org/uniprotkb/E1BDP9" } ], "pmid": "" }, { "name": "negative regulation of protein K63-linked ubiquitination", "id": "GO:1900045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900045", "evidence": [ { "database": "UniProtKB", "id": "E1BDP9", "url": "https://www.uniprot.org/uniprotkb/E1BDP9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "E1BDP9", "url": "https://www.uniprot.org/uniprotkb/E1BDP9" } ], "pmid": "" }, { "name": "centriolar satellite", "id": "GO:0034451", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034451", "evidence": [ { "database": "UniProtKB", "id": "E1BDP9", "url": "https://www.uniprot.org/uniprotkb/E1BDP9" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "E1BDP9", "url": "https://www.uniprot.org/uniprotkb/E1BDP9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "E1BDP9", "url": "https://www.uniprot.org/uniprotkb/E1BDP9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 241, "end_pos": 243, "annotation": "n_glycosylation_sequon" }, { "start_pos": 632, "end_pos": 634, "annotation": "n_glycosylation_sequon" }, { "start_pos": 635, "end_pos": 637, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDP9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 705, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDP9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDP9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDP9" }, { "id": "PF25771", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25771" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CEP63/Deup1 CEP152 binding coiled coil", "eco_id": "ECO_0000259", "start_pos": 666, "end_pos": 701, "start_aa": "Thr", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BDP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDP9" }, { "id": "PF17045", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17045" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CEP63/Deup1 N-terminal", "eco_id": "ECO_0000259", "start_pos": 18, "end_pos": 280, "start_aa": "Leu", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 217, "end_pos": 219 }, { "start_pos": 241, "end_pos": 243 }, { "start_pos": 632, "end_pos": 634 }, { "start_pos": 635, "end_pos": 637 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BA27-1", "uniprot_ac": "E1BA27", "uniprot_id": "E1BA27_BOVIN", "mass": { "chemical_mass": 67690.0, "monoisotopic_mass": 67690.0 }, "refseq": { "ac": "XP_005204315", "name": "glomulin isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204315" }, "gene_names": [ { "name": "GLMN", "type": "recommended", "evidence": [ { "id": "E1BA27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA27" } ] }, { "name": "GLMN", "type": "synonym", "evidence": [ { "id": "XP_005204315", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204315" } ] } ], "protein_names": [ { "name": "Glomulin, FKBP associated protein", "type": "synonym", "evidence": [ { "id": "E1BA27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA27/entry#names_and_taxonomy" } ] }, { "name": "glomulin isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005204315", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204315" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BA27", "url": "https://www.uniprot.org/uniprotkb/E1BA27" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GLMN", "url": "https://www.uniprot.org/uniprotkb/E1BA27", "locus": { "chromosome": "3", "start_pos": 51167321, "end_pos": 51123185, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018737", "url": "https://www.ensembl.org/id/ENSBTAG00000018737" } ] } } ], "crossref": [ { "id": "E1BA27", "url": "https://alphafold.ebi.ac.uk/entry/E1BA27", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018737", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018737", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504211", "url": "https://www.ncbi.nlm.nih.gov/gene/504211", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019516", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019516", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TLCPMEH", "url": "https://omabrowser.org/oma/group/TLCPMEH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LJE7", "url": "https://www.orthodb.org/?gene=A0A3Q1LJE7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BA27", "url": "https://www.orthodb.org/?gene=E1BA27", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15430", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15430", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15430:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15430:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08568", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08568", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005204315", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204315", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJE7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJE7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJE7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA27", "url": "https://www.uniprot.org/uniprotkb/E1BA27", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA27-1", "url": "https://www.uniprot.org/uniprotkb/E1BA27-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVEELQSIIKRCQILEEQDFKEEDFGLFQLAGQRCIDEGHIDQLLEIIQNEKNKVIVKNMGWNLVGPVVRSLLRNEKEDDKRKCHFLLLDLLVKLCNPKELLLGLLELIEEPSGKQISQIILLLLQPLQTVIQKLRNNKAYSVGLALSTLWSQLSLLPVPYSKEQIQADDYGLCQCCKALIEFTKPFVEYVIDNKENSMENEKLKDEILKFCLKSLKCPLLTAQFLEQSEEAGDDPLKCFASEIIGFLSAIGYPFPKMIFNHGRKKKIWDYLEFEEEEDKQLSDSMASLAYLVFVQGISIDQLPMVLSPSYLLQFNMGHIEVLLQRTEESVFSKGLDLLENGLLRIEDNSLLHQYLEIKSFLTVPQGLVKVMTLCPIETLRKKGLAVLQLYINKLDPQGKYTLFRCLLSTSNHSGVEAFIIQNIKNQIDISLKKTQNKWFTGPQLISLLDLVLVLPEGAETDLLQNSDRIMASLNLLRYLVIKDNEKDNQTGLWTELEKIENNFLKPLHTGLNMSKAHYEAEIKNSQEVQKSKDHCSLNVGREEIPNMPPEMQLKVLHSALFTFDLIESVLARVEELIETKTKSTSEENMG", "length": 592, "header": "tr|E1BA27-1|E1BA27_BOVIN Isoform 1 of Glomulin, FKBP associated protein OS=Bos taurus OX=9913 GN=GLMN PE=4 SV=2 CANONICAL=E1BA27-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJE7-1", "url": "https://www.uniprot.org/uniprotkb/E1BA27/entry#A0A3Q1LJE7-1", "sequence": { "sequence": "MAVEELQSIIKRCQILEEQDFKEEDFGLFQLAGQRCIDEGHIDQLLEIIQNEKNKLCNPKELLLGLLELIEEPSGKQISQIILLLLQPLQTVIQKLRNNKAYSVGLALSTLWSQLSLLPVPYSKEQIQADDYGLCQCCKALIEFTKPFVEYVIDNKENSMENEKLKDEILKFCLKSLKCPLLTAQFLEQSEEAGDDPLKCFASEIIGFLSAIGYPFPKMIFNHGRKKKIWDYLEFEEEEDKQLSDSMASLAYLVFVQGISIDQLPMVLSPSYLLQFNMGHIEVLLQRTEESVFSKGLDLLENGLLRIEDNSLLHQYLEIKSFLTVPQGLVKVMTLCPIETLRKKGLAVLQLYINKLDPQGKYTLFRCLLSTSNHSGVEAFIIQNIKNQIDISLKKTQNKWFTGPQLISLLDLVLVLPEGAETDLLQNSDRIMASLNLLRYLVIKDNEKDNQTGLWTELEKIENNFLKPLHTGLNMSKAHYEAEIKNSQEVQKSKDHCSLNVGREEIPNMPPEMQLKVLHSALFTFDLIESVLARVEELIETKTKSTSEENMG", "length": 552, "header": "tr|A0A3Q1LJE7-1|E1BA27_BOVIN Computationally mapped isoform of Glomulin, FKBP associated protein OS=Bos taurus OX=9913 GN=GLMN PE=4 SV=2 CANONICAL=E1BA27-1" }, "locus": { "chromosome": "3", "start_pos": 51166509, "end_pos": 51123210, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068653.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068653.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059512.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059512.2" } ] } }, { "isoform_ac": "E1BA27-1", "url": "https://www.uniprot.org/uniprotkb/E1BA27/entry#E1BA27-1", "sequence": { "sequence": "MAVEELQSIIKRCQILEEQDFKEEDFGLFQLAGQRCIDEGHIDQLLEIIQNEKNKVIVKNMGWNLVGPVVRSLLRNEKEDDKRKCHFLLLDLLVKLCNPKELLLGLLELIEEPSGKQISQIILLLLQPLQTVIQKLRNNKAYSVGLALSTLWSQLSLLPVPYSKEQIQADDYGLCQCCKALIEFTKPFVEYVIDNKENSMENEKLKDEILKFCLKSLKCPLLTAQFLEQSEEAGDDPLKCFASEIIGFLSAIGYPFPKMIFNHGRKKKIWDYLEFEEEEDKQLSDSMASLAYLVFVQGISIDQLPMVLSPSYLLQFNMGHIEVLLQRTEESVFSKGLDLLENGLLRIEDNSLLHQYLEIKSFLTVPQGLVKVMTLCPIETLRKKGLAVLQLYINKLDPQGKYTLFRCLLSTSNHSGVEAFIIQNIKNQIDISLKKTQNKWFTGPQLISLLDLVLVLPEGAETDLLQNSDRIMASLNLLRYLVIKDNEKDNQTGLWTELEKIENNFLKPLHTGLNMSKAHYEAEIKNSQEVQKSKDHCSLNVGREEIPNMPPEMQLKVLHSALFTFDLIESVLARVEELIETKTKSTSEENMG", "length": 592, "header": "tr|E1BA27-1|E1BA27_BOVIN Isoform 1 of Glomulin, FKBP associated protein OS=Bos taurus OX=9913 GN=GLMN PE=4 SV=2 CANONICAL=E1BA27-1" }, "locus": { "chromosome": "3", "start_pos": 51166509, "end_pos": 51123210, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024943.8", "url": "https://www.ensembl.org/id/ENSBTAT00000024943.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024943.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024943.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7GB95-1", "protein_name": "Glomulin isoform X1", "gene_name": "Glmn", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLCWSPPKAFSSGGSVISLTRLGHLLGMAVEELQCIIKRCQILEECDFKEEDFGLFQLAGQRCIDDGHVDQLLEIIQDEKNKTIIKSMGWNLVGPVVRCLLRNGEEDKREDCFLMFDLLLKLCNPKELLLGLLELIEEPSGKQISQIILLLLQPLQTVLQKLPNNKAYSVGLALSTLWSQLSLLPVPYSEEQIQTDDYGLCQCCKALIEFIRPFVEEVIDNKENKENEKLKDELLKFCFKSLKCPLLTAQFLEQSEDVGNDPFRCFACEIIGFLSQIGHPVPKIILNHGRKKRTWDNLEFEEEDDKQLADSVASLTYLVFVQGIGIGQLPMVLSPSYLLQLNMEHIELFLQRTEQSIFSKGLELLENSLLRLEDSSLLYQYLEIKSFLAVPQGLVKVMTLCPIETLRKKGLAMLQLYIDKLDSQGKYTLFRCLLNTSNHSGVEGFIIQNIKNQIDASFKKTYNKWFAGPQLISLLDLVLFLPEGAETDLLQNSDRIMASLNLLRYLVIKDNENDNQTGLWTDLGKIENNFLKPLHIGLNMSKAHYEAEIKNSQQNSQVASTCKGVCSVTVGGEEIPSMPPEMQLKVLHSALFTFDLIESVLARVEELIEIKTKSTSEENVGIK", "length": 623 }, "evidence": [ { "id": "E1BA27", "url": "https://omabrowser.org/oma/group/E1BA27/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0AC58GRH6-1", "protein_name": "Glomulin, FKBP associated protein a isoform X1", "gene_name": "glmna", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNKAFRSISMALDQLSDMVQRCQTVKDESFAPEDYDLFTAAGSTCIEQGDSAQVLSILVDEKNQNIVRCMGWNLLGPLVKMLLKKEDKTLPHCHAILLHLLEVCSPKELLVGLLEQVEEADSGSIAETITLLLKPLQTVLLRLGIRKASSVGMALSTLLSQVSRLPVPVTAEQEEDDVFGLCRCCSALLQFVKPFVEEIKEVVKDNNSISKDNELRVELLKFCMKSLSEPLLEVQLKDTDTLQRSPLRDFATEILIILSDIGESLPDLLSRNVLRRRKVPGFLEEEVRYPKESLACMSHLLFVDHIAVDIFPAVFSPIFVLQCNMEYIELLLSRTEENRLQKGLELYEKSLVRVEENSLPVDLLELKTFFSVPQNLVKVMTMCPDQTLRTKGLKVFQLSIDKFNTEAKYKFFRGMLKTSHHAGVEGYIIKNIKNQIDSSLKPGNSNDWFLGKHLLPLLRLVLCLPQGPETDLLQNLDRIMESLNLLRYMLIRDKEWDNETGIWTELYKIEDNYLKPMRTGLNMSKAHYEAELRSTKENRKIGLKEAKASVCSVTVGNEKLPNMTPETQIQVLQSALFTFDLIESVLARIEEIIEAKDRPQS", "length": 601 }, "evidence": [ { "id": "E1BA27", "url": "https://omabrowser.org/oma/group/E1BA27/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZKQ3-1", "protein_name": "Glomulin, FKBP associated protein", "gene_name": "Glmn", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAVEELQCIIKRCQILEEHDFKEEDFGLFQLAGQRCIEDGYINQLLEIIQDEKNKTIIKTMGWNLVGPVVRCLLRGREEDKREECFLIFDLLVKLCNPKELLLGLLELIEEPSGKQISQIILLLLQPLQTVIQKLPNNKAYSAGLALSTLWSQLSLLPVPHSEEQIQADDYGLCQCCRALIEFTKPFVAEVASDKEDPANTKLKDELLKFCFKSLKCPLLTAQFLEQSEEVGNDPFRCFASEIIGFLSQIGYPVPQIILNHGRKKRTWDYLEFEEEEDRQLADSVAALTYLVFVQGIGTDQLPMVLSPSYLLQLNMEHIEVLLQRTEQSVYSKGLELLETSLLRLEDNSLCYQYLEIKSFLAVPQGLVKVMTLCPIETLRKTGLAMLQLYIDKLDSQGKYTLFRCLLNTSNHSGVEAFVIQNIKNQIDLSYKKTHNRWFAGAQLTSLLDLVLSLPEGAETDLLQNSDRIMASLNLLRYLVIKDNEDDNQTGLWTELGKIENNFLQPLHVGLNMSKAHYEAEIKNSQQNSQAASMCKSVCSVTVGGEEIPTMPPEMQLKVLHSALFTFDLIESVLARVEELIEIKSKSTSEENAGMK", "length": 596 }, "evidence": [ { "id": "E1BA27", "url": "https://omabrowser.org/oma/group/E1BA27/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BZM1-1", "protein_name": "Glomulin", "gene_name": "Glmn", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAVEELQSIIKRCQILEEHDFKEEDFGLFQLAGQRCIEDGYINQLLEIIQDEKNKTIIKSMGWNLVGPVVRCLLRGREEDKREECFLIFDLLVKLCNPKELLLGLLELIEEPSGKQISQIILLLLQPLQTVIQKLPNNKAYSVGLALSTLWSQLSLLPVPHSEEQIQADDYGLCQCCKALIEFTKPFVEEVISDKENKENAKLKDELLKFCFKGLKCPLLTAQFLEQSEDVGNDPFRCFASEIIGFLSKIGHPVPQIILNHGRKKRTWDYLEFEEEEDKQLAESVASLTYLVFVQGIGIDQLPMVLSPSYLLQLNMEHIEVFLQRTEQSIYSKGLELLETSLLRLEDNSLCYQYLEIKSFLAVPQGLVKVMTLCPIETLRKKGLSMLQLFIDKLDSQGKYTLFRCLLNTSNHSGVEAFVIQNIKNQIDLSFKKTYNKWFAGAQLISLLDLVLSLPEGAETDLLQNSDRIMASLNLLRYLVIKDNEDDNQTGLWTELGKIENNFLKPLHIGLNMSKAHYEAEIKNSQQNNQVASMCKGVCSVTVGGEEIPSMPPEMQLKVLHSALFTFDLIESVLARVEELIEIKSKSTSEENVGIK", "length": 596 }, "evidence": [ { "id": "E1BA27", "url": "https://omabrowser.org/oma/group/E1BA27/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92990-1", "protein_name": "Glomulin", "gene_name": "GLMN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAVEELQSIIKRCQILEEQDFKEEDFGLFQLAGQRCIEEGHTDQLLEIIQNEKNKVIIKNMGWNLVGPVVRCLLCKDKEDSKRKVYFLIFDLLVKLCNPKELLLGLLELIEEPSGKQISQSILLLLQPLQTVIQKLHNKAYSIGLALSTLWNQLSLLPVPYSKEQIQMDDYGLCQCCKALIEFTKPFVEEVIDNKENSLENEKLKDELLKFCFKSLKCPLLTAQFFEQSEEGGNDPFRYFASEIIGFLSAIGHPFPKMIFNHGRKKRTWNYLEFEEEENKQLADSMASLAYLVFVQGIHIDQLPMVLSPLYLLQFNMGHIEVFLQRTEESVISKGLELLENSLLRIEDNSLLYQYLEIKSFLTVPQGLVKVMTLCPIETLRKKSLAMLQLYINKLDSQGKYTLFRCLLNTSNHSGVEAFIIQNIKNQIDMSLKRTRNNKWFTGPQLISLLDLVLFLPEGAETDLLQNSDRIMASLNLLRYLVIKDNENDNQTGLWTELGNIENNFLKPLHIGLNMSKAHYEAEIKNSQEAQKSKDLCSITVSGEEIPNMPPEMQLKVLHSALFTFDLIESVLARVEELIEIKTKSTSEENIGIK", "length": 594 }, "evidence": [ { "id": "E1BA27", "url": "https://omabrowser.org/oma/group/E1BA27/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Cul4A-RING E3 ubiquitin ligase complex", "id": "GO:0031464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031464", "evidence": [ { "database": "UniProtKB", "id": "E1BA27", "url": "https://www.uniprot.org/uniprotkb/E1BA27" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BA27", "url": "https://www.uniprot.org/uniprotkb/E1BA27" } ], "pmid": "" }, { "name": "Cul2-RING ubiquitin ligase complex", "id": "GO:0031462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031462", "evidence": [ { "database": "UniProtKB", "id": "E1BA27", "url": "https://www.uniprot.org/uniprotkb/E1BA27" } ], "pmid": "" }, { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "E1BA27", "url": "https://www.uniprot.org/uniprotkb/E1BA27" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "hepatocyte growth factor receptor binding", "id": "GO:0005171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005171", "evidence": [ { "database": "UniProtKB", "id": "E1BA27", "url": "https://www.uniprot.org/uniprotkb/E1BA27" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "E1BA27", "url": "https://www.uniprot.org/uniprotkb/E1BA27" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase inhibitor activity", "id": "GO:0055105", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055105", "evidence": [ { "database": "UniProtKB", "id": "E1BA27", "url": "https://www.uniprot.org/uniprotkb/E1BA27" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "vasculogenesis", "id": "GO:0001570", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001570", "evidence": [ { "database": "UniProtKB", "id": "E1BA27", "url": "https://www.uniprot.org/uniprotkb/E1BA27" } ], "pmid": "" }, { "name": "negative regulation of T cell proliferation", "id": "GO:0042130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042130", "evidence": [ { "database": "UniProtKB", "id": "E1BA27", "url": "https://www.uniprot.org/uniprotkb/E1BA27" } ], "pmid": "" }, { "name": "positive regulation of cytokine production", "id": "GO:0001819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001819", "evidence": [ { "database": "UniProtKB", "id": "E1BA27", "url": "https://www.uniprot.org/uniprotkb/E1BA27" } ], "pmid": "" }, { "name": "positive regulation of phosphorylation", "id": "GO:0042327", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042327", "evidence": [ { "database": "UniProtKB", "id": "E1BA27", "url": "https://www.uniprot.org/uniprotkb/E1BA27" } ], "pmid": "" }, { "name": "epigenetic regulation of gene expression", "id": "GO:0040029", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0040029", "evidence": [ { "database": "UniProtKB", "id": "E1BA27", "url": "https://www.uniprot.org/uniprotkb/E1BA27" } ], "pmid": "" }, { "name": "muscle cell differentiation", "id": "GO:0042692", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042692", "evidence": [ { "database": "UniProtKB", "id": "E1BA27", "url": "https://www.uniprot.org/uniprotkb/E1BA27" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 413, "end_pos": 415, "annotation": "n_glycosylation_sequon" }, { "start_pos": 490, "end_pos": 492, "annotation": "n_glycosylation_sequon" }, { "start_pos": 514, "end_pos": 516, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BA27-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 592, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BA27-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BA27" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 413, "end_pos": 415 }, { "start_pos": 490, "end_pos": 492 }, { "start_pos": 514, "end_pos": 516 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B7L7-1", "uniprot_ac": "E1B7L7", "uniprot_id": "UBN2_BOVIN", "mass": { "chemical_mass": 144390.0, "monoisotopic_mass": 144390.0 }, "refseq": { "ac": "XP_005205927", "name": "ubinuclein-2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205927" }, "gene_names": [ { "name": "UBN2", "type": "recommended", "evidence": [ { "id": "E1B7L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L7" } ] }, { "name": "UBN2", "type": "synonym", "evidence": [ { "id": "XP_005205927", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205927" } ] } ], "protein_names": [ { "name": "Ubinuclein-2", "type": "recommended", "evidence": [ { "id": "E1B7L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L7/entry#names_and_taxonomy" } ] }, { "name": "ubinuclein-2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005205927", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205927" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7L7", "url": "https://www.uniprot.org/uniprotkb/E1B7L7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBN2", "url": "https://www.uniprot.org/uniprotkb/E1B7L7", "locus": { "chromosome": "4", "start_pos": 102871012, "end_pos": 102782798, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014021", "url": "https://www.ensembl.org/id/ENSBTAG00000014021" } ] } } ], "crossref": [ { "id": "E1B7L7", "url": "https://alphafold.ebi.ac.uk/entry/E1B7L7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014021", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014021", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540792", "url": "https://www.ncbi.nlm.nih.gov/gene/540792", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR014840", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014840", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026947", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026947", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540792", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540792", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PKVKKVM", "url": "https://omabrowser.org/oma/group/PKVKKVM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LLI4", "url": "https://www.orthodb.org/?gene=A0A3Q1LLI4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MEB3", "url": "https://www.orthodb.org/?gene=A0A3Q1MEB3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N510", "url": "https://www.orthodb.org/?gene=A0A3Q1N510", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B7L7", "url": "https://www.orthodb.org/?gene=E1B7L7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G5E568", "url": "https://www.orthodb.org/?gene=G5E568", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21669", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21669", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21669:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21669:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08729", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08729", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14075", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14075", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005205927", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205927", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLI4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLI4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLI4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEB3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEB3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEB3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N510", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N510", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N510-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N510-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7L7", "url": "https://www.uniprot.org/uniprotkb/E1B7L7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7L7-1", "url": "https://www.uniprot.org/uniprotkb/E1B7L7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E568", "url": "https://www.uniprot.org/uniprotkb/G5E568", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E568-1", "url": "https://www.uniprot.org/uniprotkb/G5E568-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEPRRVAFISLSPVRRREAEFPGTEREPEYPREPPRLEPQPYREPARTEPPAPREVAPRSDAQPPPREKPLPQREVSRAEPPMSLQREPPRPEPPPPPLPQLHLQPPPPRESTSRAEPQPRPPRETVRLELVLKDPTDESCVEFSYPELLLCGEQRKKPVYTEDPFNDDHQERQEVEMLAKKFEMKYGGKPRKHRRDRLQDLIDIGFGYDETDPFIDNSEAYDELVPASLTTKYGGFYINTGTLQFRQASDTEEDDTTDNQKHKPPKIPKIKEDDIEMKKRKRKEEGEKEKKPRKKVPKQLGVMALNSHKSEKKKKRYKDSLSLAAMIRKFQKEKDALKKESNPKTPLNFSTSSLNKPPSAAVALGNDVSDLNLTSADPDLPIFVSTNEHELFQEAENALEMLDDFDFDRLLDAASNGSPLSESGGENGNTTQPTYASQVMPKVVPTLPEGLPVLLEKRIEDLRVAAKLFDEEGRKKFFTQDMNNILLDIELQLQELGPVIRSGVYSHLEAFVPCNKETLVKRLKKLHLNVQDDRLREPLQKLKLAVSNVMPEQLFKYQEDCQARNQAKCAKFQTDEEREKNGSEEDDEEKPGKRVIGPRKKFHWDDTIRTLLCNLVEIKLGCYELEPNKSQSAEDYLKSFMETEVKPLWPKGWMQARMLFKESRSVHNHLTSAPAKKKVIPAPKPKVKECSPKKDQKTPASSVASVGGPSTSSSTSAVASTSSGSTPVQETICLDDSLDEELSFHPPALDLVSEALAVINNGNKGPPAGSRISMPTAKPRPGLREEKLASIMSKLPLATPKKLDSTQTAHSSSLIAGHTGPVPKKPQDLAHTGISSGLIAGSSIQNPKVSLEPLPARLLQQGLQRSSQIHASSSSQTHVSSSSQAQVAASSHTLGTSEAQDASPLTQVTKVHQHSAVQQNYVSPLQATISKSQTNPVVKLSNNPQLSCSSPLTKTSDKPLMYRLPLSTPPPGNGSQGSHSLVSRTVPSTTTSTNYLAKAMVSQISTQGFKSPFSMAASPKLASSPKPATSPKPLPSPKPSASPKPSQSAKPSVSTKLISKSNPTPKPTVSPSSSSPNALVAQSSHSSSNNPVHKQPSGMNISRQSPTLNLLPLNRTSGLPSTKNLQAPSKLTNSPSTGTVGKNSLSGIAMNVPASRGSNLNSSGANRTSLSGGTGSGTQGATKPLSTPHRPSSASGSSVVAASVQSTAGASLLANASPLTLMTSPLSVTNQNVTPFGMLGGLVPVTMPFQFPLELLGFGTDTAGVTTTSGSTSAAFHHSLTQNLLKGLQPGAQHAAALSHAPLPTHVQQTFNDGGQSKGDTKLPRKSQ", "length": 1330, "header": "sp|E1B7L7-1|UBN2_BOVIN Isoform 1 of Ubinuclein-2 OS=Bos taurus OX=9913 GN=UBN2 PE=3 SV=1 CANONICAL=E1B7L7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LLI4-1", "url": "https://www.uniprot.org/uniprotkb/E1B7L7/entry#A0A3Q1LLI4-1", "sequence": { "sequence": "MAEPRRVAFISLSPVRRREAEFPGTEREPEYPREPPRLEPQPYREPARTEPPAPREVAPRSDAQPPPREKPLPQREVSRAEPPMSLQREPPRPEPPPPPLPQLHLQPPPPRESTSRAEPQPRPPRETVRLELVLKDPTDESCVEFSYPELLLCGEQRKKPVYTEDPFNDDHQERQEVEMLAKKFEMKYGGKPRKHRRDRLQDLIDIGFGYDETDPFIDNSEAYDELVPASLTTKYGGFYINTGTLQFRQASDTEEDDTTDNQKHKPPKIPKIKEDDIEMKKRKRKEEGEKEKKPRKKVPKQLGVMALNSHKSEKKKKRYKDSLSLAAMIRKFQKEKDALKKESNPKTPLNFSTSSLNKPPSAAVALGNDVSDLNLTSADPDLPIFVSTNEHELFQEAENALEMLDDFDFDRLLDAASNGSPLSESGGENGNTTQPTYASQVMPKVVPTLPEGLPVLLEKRIEDLRVAAKLFDEEGRKKFFTQDMNNILLDIELQLQELGPVIRSGVYSHLEAFVPCNKETLVKRLKKLHLNVQDDRLREPLQKLKLAVSNVMPEQLFKYQEDCQARNQAKCAKFQTDEEREKNGSEEDDEEKPGKRVIGPRKKFHWDDTIRTLLCNLVEIKLGCYELEPNKSQSAEDYLKSFMETEVKPLWPKGWMQARMLFKESRSVHNHLTSAPAKKKVIPAPKPKVKECSPKKDQKTPASSVASVGGPSTSSSTSAVASTSSGSTPVQETICLDDSLDEELSFHPPALDLVSEALAVINNGNKGPPAGSRISMPTAKPRPGLREEKLASIMSKLPLATPKKLDSTQTAHSSSLIAGHTGPVPKKPQDLAHTGISSGLIAGSSIQNPKVSLEPLPARLLQQGLQRSSQIHASSSSQTHVSSSSQAQVAASSHTLGTSEAQDASPLTQVTKVHQHSAVQQNYVSPLQATISKSQTNPVVKLSNNPQLSCSSPLTKTSDKPLMYRLPLSTPPPGNGSQGSHSLVSRTVPSTTTSTNYLAKAMVSQISTQGFKSPFSMAASPKLASSPKPATSPKPLPSPKPSASPKPSQSAKPSVSTKLISKSNPTPKPTVSPSSSSPNALVAQSSHSSSNNPVHKQPSGMNISRQSPTLNLLPLNRTSGLPSTKNLQAPSKLTNSPSTGTVGKNSLSGIAMNVPASRGSNLNSSGANRTSLSGGTGSGTQGATKPLSTPHRPSSASGSSVVAASVQSTAGASLLANASPLTLMTSPLSVTNQNVTPFGMLGGLVPVTMPFQFPLELLGFGTDTAGVTTTSGSTSAAFHHSLTQNLLKGLQPGAQHAAALSHAPLPTHVQQTFNGKRAPRFFLYLIFIQIYQYIKSFLKTM", "length": 1341, "header": "tr|A0A3Q1LLI4-1|UBN2_BOVIN Computationally mapped isoform of Ubinuclein-2 OS=Bos taurus OX=9913 GN=UBN2 PE=3 SV=1 CANONICAL=E1B7L7-1" }, "locus": { "chromosome": "4", "start_pos": 102851901, "end_pos": 102782997, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076117.1", "url": "https://www.ensembl.org/id/ENSBTAT00000076117.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060636.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060636.1" } ] } }, { "isoform_ac": "A0A3Q1MEB3-1", "url": "https://www.uniprot.org/uniprotkb/E1B7L7/entry#A0A3Q1MEB3-1", "sequence": { "sequence": "MAEPRRVAFISLSPVRRREAEFPGTEREPEYPREPPRLEPQPYREPARTEPPAPREVAPRSDAQPPPREKPLPQREVSRAEPPMSLQREPPRPEPPPPPLPQLHLQPPPPRESTSRAEPQPRPPRETVRLELVLKDPTDESCVEFSYPELLLCGEQRKKPVYTEDPFNDDHQERQEVEMLAKKFEMKYGGKPRKHRRDRLQDLIDIGFGYDETDPFIDNSEAYDELVPASLTTKYGGFYINTGTLQFRQASDTEEDDTTDNQKHKPPKIPKIKEDDIEMKKRKRKEEGEKEKKPRKKVPKQLGVMALNSHKSEKKKKRYKDSLSLAAMIRKFQKEKDALKKESNPKTPLNFSTSSLNKPPSAAVALGNDVSDLNLTSADPDLPIFVSTNEHELFQEAENALEMLDDFDFDRLLDAASNGSPLSESGGENGNTTQPTYASQVMPKVVPTLPEGLPVLLEKRIEDLRVAAKLFDEEGRKKFFTQDMNNILLDIELQLQELGPVIRSGVYSHLEAFVPCNKETLVKRLKKLHLNVQDDRLREPLQKLKLAVSNVMPEQLFKYQEDCQARNQAKCAKFQTDEEREKNGSEEDDEEKPGKRVIGPRKKFHWDDTIRMLFKESRSVHNHLTSAPAKKKVIPAPKPKVKECSPKKDQKTPASSVASVGGPSTSSSTSAVASTSSGSTPVQETICLDDSLDEELSFHPPALDLVSEALAVINNGNKGPPAGSRISMPTAKPRPGLREEKLASIMSKLPLATPKKLDSTQTAHSSSLIAGHTGPVPKKPQDLAHTGISSGLIAGSSIQNPKVSLEPLPARLLQQGLQRSSQIHASSSSQTHVSSSSQAQVAASSHTLGTSEAQDASPLTQVTKVHQHSAVQQNYVSPLQATISKSQTNPVVKLSNNPQLSCSSPLTKTSDKPLMYRLPLSTPPPGNGSQGSHSLVSRTVPSTTTSTNYLAKAMVSQISTQGFKSPFSMAASPKLASSPKPATSPKPLPSPKPSASPKPSQSAKPSVSTKLISKSNPTPKPTVSPSSSSPNALVAQSSHSSSNNPVHKQPSGMNISRQSPTLNLLPLNRTSGLPSTKNLQAPSKLTNSPSTGTVGKNSLSGIAMNVPASRGSNLNSSGANRTSLSGGTGSGTQGATKPLSTPHRPSSASGSSVVAASVQSTAGASLLANASPLTLMTSPLSVTNQNVTPFGMLGGLVPVTMPFQFPLELLGFGTDTAGVTTTSGSTSAAFHHSLTQNLLKGLQPGAQHAAALSHAPLPTHVQQTFNDGGQSKGDTKLPRKSQ", "length": 1282, "header": "tr|A0A3Q1MEB3-1|UBN2_BOVIN Computationally mapped isoform of Ubinuclein-2 OS=Bos taurus OX=9913 GN=UBN2 PE=3 SV=1 CANONICAL=E1B7L7-1" }, "locus": { "chromosome": "4", "start_pos": 102851901, "end_pos": 102782997, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069996.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069996.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072502.1", "url": "https://www.ensembl.org/id/ENSBTAP00000072502.1" } ] } }, { "isoform_ac": "A0A3Q1N510-1", "url": "https://www.uniprot.org/uniprotkb/E1B7L7/entry#A0A3Q1N510-1", "sequence": { "sequence": "MAEPRRVAFISLSPVRRREAEFPGTEREPEYPREPPRLEPQPYREPARTEPPAPREVAPRSDAQPPPREKPLPQREVSRAEPPMSLQREPPRPEPPPPPLPQLHLQPPPPRESTSRAEPQPRPPRETVRLELVLKDPTDESCVEFSYPELLLCGEQRKKPVYTEDPFNDDHQERQEVEMLAKKFEMKYGGKPRKHRRDRLQDLIDIGFGYDETDPFIDNSEAYDELVPASLTTKYGGFYINTGTLQFRQASDTEEDDTTDNQKHKPPKIPKIKEDDIEMKKRKRKEEGEKEKKPRKKVPKQLGVMALNSHKSEKKKKRYKDSLSLAAMIRKFQKEKDALKKESNPKTPLNFSTSSLNKPPSAAVALGNDVSDLNLTSADPDLPIFVSTNEHELFQEAENALEMLDDFDFDRLLDAASNGSPLSESGGENGNTTQPTYASQVMPKVVPTLPEGLPVLLEKRIEDLRVAAKLFDEEGRKKFFTQDMNNILLDIELQLQELGPVIRSGVYSHLEAFVPCNKETLVKRLKKLHLNVQDDRLREPLQKLKLAVSNVMPEQLFKYQEDCQARNQAKCAKFQTDEEREKNGSEEDDEEKPGKRVIGPRKKFHWDDTIRTLLCNLVEIKLGCYELEPNKSQSAEDYLKSFMETEVKPLWPKGWMQARMLFKESRSVHNHLTSAPAKKKVIPAPKPKVKECSPKKDQKTPASSVASVGGPSTSSSTSAVASTSSGSTPVQETICLDDSLDEELSFHPPALDLVSEALAVINNGNKGPPAGSRISMPTAKPRPGLREEKLASIMSKLPLATPKKLDSTQTAHSSSLIAGHTGPVPKKPQDLAHTGISSGLIAGSSIQNPKVSLEPLPARLLQQGLQRSSQIHASSSSQTHVSSSSQAQVAASSHTLGTSEAQDASPLTQVTKVHQHSAVQQNYVSPLQATISKSQTNPVVKLSNNPQLSCSSPLTKTSDKPLMYRLPLSTPPPGNGSQGSHSLVSRTVPSTTTSTNYLAKAMVSQISTQGFKSPFSMAASPKLASSPKPATSPKPLPSPKPSASPKPSQSAKPSVSTKLISKSNPTPKPTVSPSSSSPNALVAQSSHSSSNNPVHKQPSGMNISRQSPTLNLLPLNRTSGLPSTKNLQAPSKLTNSPSTGTVGKNSLSGIAMNVPASRGSNLNSSGANRTSLSGGTGSGTQGATKPLSTPHRPSSASGSSVVAASVQFHQKPQRPRTKQ", "length": 1219, "header": "tr|A0A3Q1N510-1|UBN2_BOVIN Computationally mapped isoform of Ubinuclein-2 OS=Bos taurus OX=9913 GN=UBN2 PE=3 SV=2 CANONICAL=E1B7L7-1" }, "locus": { "chromosome": "4", "start_pos": 102870911, "end_pos": 102782997, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079892.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079892.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065048.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065048.2" } ] } }, { "isoform_ac": "E1B7L7-1", "url": "https://www.uniprot.org/uniprotkb/E1B7L7/entry#E1B7L7-1", "sequence": { "sequence": "MAEPRRVAFISLSPVRRREAEFPGTEREPEYPREPPRLEPQPYREPARTEPPAPREVAPRSDAQPPPREKPLPQREVSRAEPPMSLQREPPRPEPPPPPLPQLHLQPPPPRESTSRAEPQPRPPRETVRLELVLKDPTDESCVEFSYPELLLCGEQRKKPVYTEDPFNDDHQERQEVEMLAKKFEMKYGGKPRKHRRDRLQDLIDIGFGYDETDPFIDNSEAYDELVPASLTTKYGGFYINTGTLQFRQASDTEEDDTTDNQKHKPPKIPKIKEDDIEMKKRKRKEEGEKEKKPRKKVPKQLGVMALNSHKSEKKKKRYKDSLSLAAMIRKFQKEKDALKKESNPKTPLNFSTSSLNKPPSAAVALGNDVSDLNLTSADPDLPIFVSTNEHELFQEAENALEMLDDFDFDRLLDAASNGSPLSESGGENGNTTQPTYASQVMPKVVPTLPEGLPVLLEKRIEDLRVAAKLFDEEGRKKFFTQDMNNILLDIELQLQELGPVIRSGVYSHLEAFVPCNKETLVKRLKKLHLNVQDDRLREPLQKLKLAVSNVMPEQLFKYQEDCQARNQAKCAKFQTDEEREKNGSEEDDEEKPGKRVIGPRKKFHWDDTIRTLLCNLVEIKLGCYELEPNKSQSAEDYLKSFMETEVKPLWPKGWMQARMLFKESRSVHNHLTSAPAKKKVIPAPKPKVKECSPKKDQKTPASSVASVGGPSTSSSTSAVASTSSGSTPVQETICLDDSLDEELSFHPPALDLVSEALAVINNGNKGPPAGSRISMPTAKPRPGLREEKLASIMSKLPLATPKKLDSTQTAHSSSLIAGHTGPVPKKPQDLAHTGISSGLIAGSSIQNPKVSLEPLPARLLQQGLQRSSQIHASSSSQTHVSSSSQAQVAASSHTLGTSEAQDASPLTQVTKVHQHSAVQQNYVSPLQATISKSQTNPVVKLSNNPQLSCSSPLTKTSDKPLMYRLPLSTPPPGNGSQGSHSLVSRTVPSTTTSTNYLAKAMVSQISTQGFKSPFSMAASPKLASSPKPATSPKPLPSPKPSASPKPSQSAKPSVSTKLISKSNPTPKPTVSPSSSSPNALVAQSSHSSSNNPVHKQPSGMNISRQSPTLNLLPLNRTSGLPSTKNLQAPSKLTNSPSTGTVGKNSLSGIAMNVPASRGSNLNSSGANRTSLSGGTGSGTQGATKPLSTPHRPSSASGSSVVAASVQSTAGASLLANASPLTLMTSPLSVTNQNVTPFGMLGGLVPVTMPFQFPLELLGFGTDTAGVTTTSGSTSAAFHHSLTQNLLKGLQPGAQHAAALSHAPLPTHVQQTFNDGGQSKGDTKLPRKSQ", "length": 1330, "header": "sp|E1B7L7-1|UBN2_BOVIN Isoform 1 of Ubinuclein-2 OS=Bos taurus OX=9913 GN=UBN2 PE=3 SV=1 CANONICAL=E1B7L7-1" }, "locus": {} }, { "isoform_ac": "G5E568-1", "url": "https://www.uniprot.org/uniprotkb/E1B7L7/entry#G5E568-1", "sequence": { "sequence": "MAEPRRVAFISLSPVRRREAEFPGTEREPEYPREPPRLEPQPYREPARTEPPAPREVAPRSDAQPPPREKPLPQREVSRAEPPMSLQREPPRPEPPPPPLPQLHLQPPPPRESTSRAEPQPRPPRETVRLELVLKDPTDESCVEFSYPELLLCGEQRKKPVYTEDPFNDDHQERQEVEMLAKKFEMKYGGKPRKHRRDRLQDLIDIGFGYDETDPFIDNSEAYDELVPASLTTKYGGFYINTGTLQFRQASDTEEDDTTDNQKHKPPKIPKIKEDDIEMKKRKRKEEGEKEKKPRKKVPKQLGVMALNSHKSEKKKKRYKDSLSLAAMIRKFQKEKDALKKESNPKTPLNFSTSSLNKPPSAAVALGNDVSDLNLTSADPDLPIFVSTNEHELFQEAENALEMLDDFDFDRLLDAASNGSPLSESGGENGNTTQPTYASQVMPKVVPTLPEGLPVLLEKRIEDLRVAAKLFDEEGRKKFFTQDMNNILLDIELQLQELGPVIRSGVYSHLEAFVPCNKETLVKRLKKLHLNVQDDRLREPLQKLKLAVSNVMPEQLFKYQEDCQARNQAKCAKFQTDEEREKNGSEEDDEEKPGKRVIGPRKKFHWDDTIRTLLCNLVEIKLGCYELEPNKSQSAEDYLKSFMETEVKPLWPKGWMQARMLFKESRSVHNHLTSAPAKKKVIPAPKPKVKMVETLFLHAFPTIVKECSPKKDQKTPASSVASVGGPSTSSSTSAVASTSSGSTPVQETICLDDSLDEELSFHPPALDLVSEALAVINNGNKGPPAGSRISMPTAKPRPGLREEKLASIMSKLPLATPKKLDSTQTAHSSSLIAGHTGPVPKKPQDLAHTGISSGLIAGSSIQNPKVSLEPLPARLLQQGLQRSSQIHASSSSQTHVSSSSQAQVAASSHTLGTSEAQDASPLTQVTKVHQHSAVQQNYVSPLQATISKSQTNPVVKLSNNPQLSCSSPLTKTSDKPLMYRLPLSTPPPGNGSQGSHSLVSRTVPSTTTSTNYLAKAMVSQISTQGFKSPFSMAASPKLASSPKPATSPKPLPSPKPSASPKPSQSAKPSVSTKLISKSNPTPKPTVSPSSSSPNALVAQSSHSSSNNPVHKQPSGMNISRQSPTLNLLPLNRTSGLPSTKNLQAPSKLTNSPSTGTVGKNSLSGIAMNVPASRGSNLNSSGANRTSLSGGTGSGTQGATKPLSTPHRPSSASGSSVVAASVQSTAGASLLANASPLTLMTSPLSVTNQNVTPFGMLGGLVPVTMPFQFPLELLGFGTDTAGVTTTSGSTSAAFHHSLTQNLLKGLQPGAQHAAALSHAPLPTHVQQTFNDGGQSKGDTKLPRKSQ", "length": 1345, "header": "tr|G5E568-1|UBN2_BOVIN Computationally mapped isoform of Ubinuclein-2 OS=Bos taurus OX=9913 GN=UBN2 PE=3 SV=1 CANONICAL=E1B7L7-1" }, "locus": { "chromosome": "4", "start_pos": 102851901, "end_pos": 102782997, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005889.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005889.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005889.4", "url": "https://www.ensembl.org/id/ENSBTAP00000005889.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 1107, "end_pos": 1107, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "E1B7L7", "url": "https://www.uniprot.org/uniprotkb/E1B7L7" } ], "site_lbl": "Ser1107" }, { "start_pos": 13, "end_pos": 13, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "E1B7L7", "url": "https://www.uniprot.org/uniprotkb/E1B7L7" } ], "site_lbl": "Ser13" }, { "start_pos": 244, "end_pos": 244, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "E1B7L7", "url": "https://www.uniprot.org/uniprotkb/E1B7L7" } ], "site_lbl": "Thr244" }, { "start_pos": 251, "end_pos": 251, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "E1B7L7", "url": "https://www.uniprot.org/uniprotkb/E1B7L7" } ], "site_lbl": "Ser251" }, { "start_pos": 253, "end_pos": 253, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "E1B7L7", "url": "https://www.uniprot.org/uniprotkb/E1B7L7" } ], "site_lbl": "Thr253" }, { "start_pos": 312, "end_pos": 312, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "E1B7L7", "url": "https://www.uniprot.org/uniprotkb/E1B7L7" } ], "site_lbl": "Ser312" }, { "start_pos": 417, "end_pos": 417, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "E1B7L7", "url": "https://www.uniprot.org/uniprotkb/E1B7L7" } ], "site_lbl": "Ser417" }, { "start_pos": 420, "end_pos": 420, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "E1B7L7", "url": "https://www.uniprot.org/uniprotkb/E1B7L7" } ], "site_lbl": "Ser420" }, { "start_pos": 423, "end_pos": 423, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "E1B7L7", "url": "https://www.uniprot.org/uniprotkb/E1B7L7" } ], "site_lbl": "Ser423" }, { "start_pos": 585, "end_pos": 585, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "E1B7L7", "url": "https://www.uniprot.org/uniprotkb/E1B7L7" } ], "site_lbl": "Ser585" } ], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540792", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540792", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YAW5-1", "protein_name": "Ubinuclein 2", "gene_name": "UBN2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAEPRRVPFISLSPVRRREAESPALERESGGREPEPPPAGREVPLLEPPPPPRESAARLEPPREPGRPEPPPQREPPRPEPPPPPRQGSRQEPPPPQEALPLRQTVRLEVVLKDPTEEGCVEFSYPELLLCREARKKSVHSEDPFNDEQRERHEVETLAKKFEAKYSGKPHKHRKDRLQDLIDIGYGYDETDPFIDNSEAYDELVPASLTTKYGGFYINTGTLQFRQASDSEDDDFAEDKKHRPPKIAKLKESEDRGMKKRKRKDEGMEKEKKPRKMKVPKQLGVMALNSHKSEKKKKKFYKDSLSLAAMIRKFQKEKEAMRKKESSPKPPVTIATSTPSKVPSSSLSAGNDISDLNLKISDPVLSIFGSTNERDLLQETESALEMLGDIDFDKLLDGTSDGSPVSELSGENGNVTHATYTSQVMTPKQVPALPEGLPTLLEKRIGDLRTAAKMFDEEGRKKFFTQDMNNILLDIELQLQEINPAIRNGVYSHLEAFVPCNKDTLIKRLKKLHLNVQDDRLREPLQKLKLAVSNVMPEQLCKYQEDCQARNLAKNAKLQTEDEREKNGSEEDDDEKPGKRVVGPRKKFHWDDTVRSLLCNLVKIKLGCYELEPNRSQSAEDYLKTFMETEVKPLWPKGWMQARMLFKESRSVHNHLTSAPAKKKVILAPKPKVKDSSPKKEQKTCISSVNSSCGTTLSTGAPVCTPSSSSCTPAPETICLDDSLDEDLSFHPPSLDSISDALAVINNGAKGSPLGSAIETPTSRPRPGLREEKLASIMSKLPLATSKKVEPAQTPHSSSLIAGHTGPVPKKPQDLVHTGISSGLIAGSSIQNPKVSLEPLPAKLLQQGLQRSSQIQAAAASSQTHVSSSKTQAAISTTSQRPKDANILVSSSEVQGGSSTSQMTKVHQHSAVQQKYVSPLQATISKSQTNPVVKLSSNPKLSCSSPVIKAQEKSVVYRLPLSNPSSGSGSQVSHPLVSRTTSSTSTSSNYLAKAMVSQVSSQGFKPPFSMAASPKPAASPKPTASKPSVTPKPNASPKFSSKSTSSPRPAATPSSSSSSALVSQSSHSSNTPLHKQTSGVNISRQSPTMNLLPSNRTSGLQPAKNPQASSKLSNSSPSGTVGKNNLGGVGMNVPASRGSNLNSSGASRTSLSGGAGSGTQGATKQLSTPHRPSSASGSPVVAASVQSTAGASLLANASPLTLMASPLSVTSQNVTSAPLTPFGMLGGLVPVTVPFQFPLELLGFGTDTAGVTTTSGSTSAAFHHSLTQNLLKGLQPGAQHAAALSHSPLPAHLQQAYTDGGQSKGDTKLQRKNQ", "length": 1314 }, "evidence": [ { "id": "E1B7L7", "url": "https://omabrowser.org/oma/group/E1B7L7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A666-1", "protein_name": "Ubinuclein-2", "gene_name": "Ubn2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEPRRVAFISLSPVRRREADFAGAEREPPRLEPQPYREPARAEPAPRADAQPPARDKPLPQREVSRAEPPMALQREPPRPEPPPPPLPLQTPPPRESASRAEPPPRPPKETVRLELVLKDPTDESCVEFSYPELLLCGEQRKKLVHTEDPFTDEHKERQEVEMLAKKFEMKYGGKARKHRKDRLQDLIDIGFGYDETDPFIDNSEAYDELVPASLTTKYGGFYINTGTLQFRQASDTEEDDFTDNQKHKPPKVPKIKDDDIEAKKRKRKEEGEKEKKPRKKVPKQLGVVALNSHKSEKKKKRYKDSLSLAAMIRKFQKEKDALKKESTPKVPVIPSTSSLPKPPCAATTLGDDIPDLSLNSADPDLPIFVSTNEHELFQEAENALEMLDDFDFDRLLDATSDGSPLSESGGENGNTTQPTFASQVVPKVVPTLPDGLPVLLEKRIEDLRVAAKLFDEEGRKKFFTQDMNNILLDIELQLQELGPVIRSGVYSHLEAFVPCNKETLVKRLKKLHLNVQDDRLREPLQKLKLAVSNVMPEQLFKYQEDCQARSQAKCAKLQADEEREKNGSDDDDDEKPGKRVIGPRKKFHWDDTIRTLLCNLVEIKLGCYELEPNKSQSAEDYLKSFMETEVKPLWPKGWMQARMLFKESRSVHNHLTSAPAKKKVIPASKPKVKEVMVKTLPVRSFPTMLKECSPKKDPKAPASVVASGGCPCTSSSTSIVASASSSSTPAQETICLDDSLDEDLSLPSASLDLVSEALAVINNGNKGPSVSSRLNVPTTKPRPGLREEKLASIMSKLPLATPKKLDSPQTAHSSSLIAGHTGPVPKKPQDLAHTGISSGLIAGSSIQNPKVSLEPLPARLLQQGLQRSSQIHASSSQTHVSSSQAQAAASSHALGTSEAQDASSLTQVTKVHQHSAVQQNYVSPLQATISKSQTNPVVKLSNNPQLSCSSQLLKTSEKPLMYRLPLSTPSPGNGSQGSHPLVSRTAPSTTTSSNYLAKAMVSQISTQGFKSPFSMAASPKLAASPKPATSPKPLTSPKPSVSPKPSLSAKPSVSTKLISKSNPTPKPAVCPSSSSPNTLVAQSSHSTSNNPAHKQPSGMNISRQSPTLNLLPSNRTSGLPTTKTLQAPSKLTNSSSAGTVGKNSLSGIPVNVPASRGSNLNSSGANRTSLSGGTGSGTQGATKPLSTPHRPTSASGSSVVTASVQSTAGASLLANASPLTLMTSPLSVTNQTVTPFGMLGGLVPVTMPFQFPLELLGFGTDTAGVTATSGSTSAALHHGLTQNLLKSLQPGTQHAATLPHSPLPTHLQQAFNDGGQSKGDTKLPRKPQ", "length": 1330 }, "evidence": [ { "id": "E1B7L7", "url": "https://omabrowser.org/oma/group/E1B7L7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6ZU65-1", "protein_name": "Ubinuclein-2", "gene_name": "UBN2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEPRRVAFISLSPVRRREAEYPGPEREPEYPREPPRLEPQPYREPARAEPPAPREPAPRSDAQPPSREKPLPQREVSRAEPPMSLQREPPRPEPPPPFPPLPLQPPPPRESASRAEQPPRPPRETVRLELVLKDPTDESCVEFSYPELLLCGEQRKKLIHTEDPFNDEHQERQEVEMLAKKFEMKYGGKPRKHRKDRLQDLIDIGFGYDETDPFIDNSEAYDELVPASLTTKYGGFYINTGTLQFRQASDTEEDDITDNQKHKPPKVPKIKEDDIEMKKRKRKEEGEKEKKPRKKVPKQLGVVALNSHKSEKKKKRYKDSLSLAAMIRKFQKEKDALKKESNPKVPVTLSTPSLNKPPCAAAALGNDVPDLNLSSGDPDLPIFVSTNEHELFQEAENALEMLDDFDFDRLLDAASDGSPLSESGGENGTTTQPTYTSQVMPKVVPTLPEGLPVLLEKRIEDLRVAAKLFDEEGRKKFFTQDMNNILLDIELQLQELGPVIRSGVYSHLEAFVPCNKETLVKRLKKLHLNVQDDRLREPLQKLKLAVSNVMPEQLFKYQEDCQARSQAKCAKLQTDEEREKNGSEEDDDEKPGKRVIGPRKKFHWDDTIRTLLCNLVEIKLGCYELEPNKSQSAEDYLKSFMETEVKPLWPKGWMQARMLFKESRSVHNHLTSAPAKKKVIPAPKPKVKEVMVKTLPLHSFPTMLKECSPKKDQKTPTSLVASVSGPPTSSSTAAIAAASSSSAPAQETICLDDSLDEDLSFHSPSLDLVSEALAVINNGNKGPPVGSRISMPTTKPRPGLREEKLASIMSKLPLATPKKLDSTQTTHSSSLIAGHTGPVPKKPQDLAHTGISSGLIAGSSIQNPKVSLEPLPARLLQQGLQRSSQIHTSSSSQTHVSSSSQAQIAASSHALGTSEAQDASSLTQVTKVHQHSAVQQNYVSPLQATISKSQTNPVVKLSNNPQLSCSSSLIKTSDKPLMYRLPLSTPSPGNGSQGSHPLVSRTVPSTTTSSNYLAKAMVSQISTQGFKSPFSMAASPKLAASPKPATSPKPLPSPKPSASPKPSLSAKPSVSTKLISKSNPTPKPTVSPSSSSPNALVAQGSHSSTNSPVHKQPSGMNISRQSPTLNLLPSSRTSGLPPTKNLQAPSKLTNSSSTGTVGKNSLSGIAMNVPASRGSNLNSSGANRTSLSGGTGSGTQGATKPLSTPHRPSTASGSSVVTASVQSTAGASLLANASPLTLMTSPLSVTNQNVTPFGMLGGLVPVTMPFQFPLEIFGFGTDTAGVTTTSGSTSAAFHHSLTQNLLKGLQPGGAQHAATLSHSPLPAHLQQAFHDGGQSKGDTKLPRKSQ", "length": 1347 }, "evidence": [ { "id": "E1B7L7", "url": "https://omabrowser.org/oma/group/E1B7L7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q80WC1-1", "protein_name": "Ubinuclein-2", "gene_name": "Ubn2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEPRRVAFISLSPVRRREADFAGAEREPPRLEPQPYREPARAEPAPRADAQPPARDKPLPQREVSRAEPPMALQREPPRPEPPPPPLPLQTPPPRESASRAEPPPRPPKETVRLELVLKDPTDESCVEFSYPELLLCGEQRKKLVHTEDPFTDEHKERQEVEMLAKKFEMKYGGKARKHRKDRLQDLIDIGFGYDETDPFIDNSEAYDELVPASLTTKYGGFYINTGTLQFRQASDTEEDDFTDNQKHKPPKVPKIKEDDIEVKKRKRKEEGEKEKKPRKKVPKQLGVVALNSHKSEKKKKRYKDSLSLAAMIRKFQKEKDALKKESTPKVPVTPSSSSLPKPPCVTTALGDDIPDLGLNSADPDLPIFVSTNEHELFQEAENALEMLDDFDFDRLLDATSDGSPLSESGGENGNTTHPTFPSQVVPKVVPTLPEGLPVLLEKRIEDLRVAAKLFDEEGRKKFFTQDMNNILLDIELQLQELGPVIRSGVYSHLEAFVPCNKETLVKRLKKLHLNVQDDRLREPLQKLKLAVSNVMPEQLFKYQEDCQARSQAKCAKLQADEEREKNGSDDDDDEKPGKRVIGPRKKFHWDDTIRTLLCNLVEIKLGCYELEPNKSQSAEDYLKSFMETEVKPLWPKGWMQARMLFKESRSVHNHLTSAPAKKKVIPASKPKVKECSPKKDPKAPASVVASGGGPSTSSSTSIVASASSSSAPAQETICLDDSLDEDLSFPSASLDLVSEALAVINNGNKGPSVGSRLNVPTTKPRPGLREEKLASIMSKLPLATPKKLDSTQTAHSSSLIAGHTGPVPKKPQDLAHTGISSGLIAGSSIQNPKVSLEPLPARLLQQGLQRSSQIHASSSSQTHVSSSQAQAAASSHALGTSEAQDASSLTQVTKVHQHSAVQQNYVSPLQATISKSQTNPVVKLSNNPQLSCSSQLLKTSDKPLMYRLPLSTPSPGNGSQGPHPLVSRTAPSTTTSSNYLAKAMVSQISTQGFKSPFSMAASPKLAASPKPATSPKPLPSPKPSVSPKPSLSAKPSISTKQISKSNPAPKPAVCPSSSSPNTLVAQSSHSTSNNPVHKQPSGMNISRQSPTLNLLPSNRTSGLPTTKTLQAPSKLTNSSSTGTAGKNSLSGIPMNVPASRGSNLNSSGANRTSLSGGTGSGTQGATKPLSTPHRPTSASGSSVVTASVQSTAGASLLANASPLTLMTSPLSVTNQTVTPFGMLGGLVPVTMPFQFPLELLGFGTDTAGVTATSGSTSAALHHSLTQNLLKSLQPGAQHAAALPHSPLPAHLQQAFNDGGQSKGDTKLPRKPQ", "length": 1314 }, "evidence": [ { "id": "E1B7L7", "url": "https://omabrowser.org/oma/group/E1B7L7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B7L7", "url": "https://www.uniprot.org/uniprotkb/E1B7L7" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1B7L7", "url": "https://www.uniprot.org/uniprotkb/E1B7L7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "E1B7L7", "url": "https://www.uniprot.org/uniprotkb/E1B7L7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1102, "end_pos": 1104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1116, "end_pos": 1118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1163, "end_pos": 1165, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1168, "end_pos": 1170, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1217, "end_pos": 1219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1234, "end_pos": 1236, "annotation": "n_glycosylation_sequon" }, { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 374, "end_pos": 376, "annotation": "n_glycosylation_sequon" }, { "start_pos": 418, "end_pos": 420, "annotation": "n_glycosylation_sequon" }, { "start_pos": 431, "end_pos": 433, "annotation": "n_glycosylation_sequon" }, { "start_pos": 583, "end_pos": 585, "annotation": "n_glycosylation_sequon" }, { "start_pos": 630, "end_pos": 632, "annotation": "n_glycosylation_sequon" }, { "start_pos": 975, "end_pos": 977, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7L7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1330, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7L7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7L7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 13, 244, 251, 253, 312, 417, 420, 423, 585, 1107 ], "sequon_annotation_sites": [ { "start_pos": 1102, "end_pos": 1104 }, { "start_pos": 1116, "end_pos": 1118 }, { "start_pos": 1163, "end_pos": 1165 }, { "start_pos": 1168, "end_pos": 1170 }, { "start_pos": 1217, "end_pos": 1219 }, { "start_pos": 1234, "end_pos": 1236 }, { "start_pos": 350, "end_pos": 352 }, { "start_pos": 374, "end_pos": 376 }, { "start_pos": 418, "end_pos": 420 }, { "start_pos": 431, "end_pos": 433 }, { "start_pos": 583, "end_pos": 585 }, { "start_pos": 630, "end_pos": 632 }, { "start_pos": 975, "end_pos": 977 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 10 }, { "field": "total_sites", "count": 10 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BB16-1", "uniprot_ac": "E1BB16", "uniprot_id": "E1BB16_BOVIN", "mass": { "chemical_mass": 195459.0, "monoisotopic_mass": 195459.0 }, "refseq": { "ac": "NP_001179188", "name": "GRIP and coiled-coil domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179188" }, "gene_names": [ { "name": "GCC2", "type": "recommended", "evidence": [ { "id": "E1BB16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB16" } ] }, { "name": "GCC2", "type": "synonym", "evidence": [ { "id": "NP_001179188", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179188" } ] } ], "protein_names": [ { "name": "GRIP and coiled-coil domain containing 2", "type": "synonym", "evidence": [ { "id": "E1BB16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB16/entry#names_and_taxonomy" } ] }, { "name": "GRIP and coiled-coil domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001179188", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179188" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BB16", "url": "https://www.uniprot.org/uniprotkb/E1BB16" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GCC2", "url": "https://www.uniprot.org/uniprotkb/E1BB16", "locus": { "chromosome": "11", "start_pos": 44805991, "end_pos": 44840325, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016038", "url": "https://www.ensembl.org/id/ENSBTAG00000016038" } ] } } ], "crossref": [ { "id": "ENSBTAG00000016038", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016038", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539484", "url": "https://www.ncbi.nlm.nih.gov/gene/539484", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000237", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000237", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032023", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032023", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539484", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539484", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TEANHFE", "url": "https://omabrowser.org/oma/group/TEANHFE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LMU5", "url": "https://www.orthodb.org/?gene=A0A3Q1LMU5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1ME69", "url": "https://www.orthodb.org/?gene=A0A3Q1ME69", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NBL7", "url": "https://www.orthodb.org/?gene=A0A3Q1NBL7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BB16", "url": "https://www.orthodb.org/?gene=E1BB16", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18902", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18902", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18902:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18902:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01465", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01465", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16704", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16704", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179188", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMU5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMU5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMU5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ME69", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ME69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ME69-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ME69-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBL7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBL7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBL7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB16", "url": "https://www.uniprot.org/uniprotkb/E1BB16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB16-1", "url": "https://www.uniprot.org/uniprotkb/E1BB16-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEPVHEGVASPAARGTGKSKLEALPKEDLIKFAKKQMMLIQKTKLRCTELEKEVEELKSKLVAGGADIIKALTERLDAVLLEKAETEQHCVSLKKENIKMKQEVEDSVTKLEDVQKELEQSQRSYGKEIENLRNELTTVHSKYSNDKADWQKEVEEAAKKQLELSEQLRFQSDSEDSVKKLQEEIQKIKLAFEDQILCLQKQLETATNEKEQEITHLQGVIEANCQQYQKDINSLQEELVRLKSTHQEEVKELMCQIETSAKEHEAEVNYLIQLKDNLVRKCEAGEMNIQKYKCELENEGKASGAGQENQVCSLLLQEDSLVEQAVNEKVRHLEDALKELESQHSILKDELTYMNNLKLKLEIDAQHIKDEFFHEREDLEFKINELLLAKEEQGYIIEKLKSELEDANKQFCCTIEQHNKEVQSLKKQHQKEITELNETFLSDSEKEKLTLMFEIQGLKEQCEKLQQEKQEAMLNYEGLREIMEILQTELGESAEKISQEFESMKQQQAFNINELQQKLQTAFNEKDALLETVNYLQKENDNLLSQQECVPELENTIKNLQEKNELYLVSLSQRDTMLQEFEAKISSLTEEKYDFISKMRSSHEEMDNLHKKCEREERLTVELREKVDQTAQYNSELEQKVNELTAGLEETLKEKDEKNRKLEKLTAQLKILSKDQEATSLEVRSLREENSRLSSEKNLLSRDLEALLSQKEGDVTFQEQINKLEEELRLAVRERDNLNKLLENEQVQKLFVKAQLCGFLEQMESKVSQEREEQDVVNILQAMGKSLDKINEEKHNLAFQYDKRIVELEEEIKLLQEEHMVQCEELRSLLTDYEQKKIVLRKELEEALLEKEALQSDLLEMKNASEQTRFENQNLLIQVEEMSQKLCRENENHHKKEKDLIKELENLRPLLEQKESELQDVKAELISLKDSFKKSTSVESDQPSVKEFEEKIGYLEKEAKEKEEKINKLKLVAVKAKKELDSSRKEAQTLQEELQSVRSERDQLSTSMRDLIQGAENYKNLLSEYDKQSEQLDAEKERANNFEHQVEDLTRQLRNLTFQCEKLTSDNEDFLARIETLQSNACLLEAQILEVHKAKAMADKELEAEKLQKEQKIKEHASSVNELEELQLQLQKEKKQLQKTMQELELVRKDAQQTTLMNMEIADYERLMRELNQKLSNKNSKIEDLEQEIKIQKQKQETLQEEMTSLQAVLQQYEEKNTKIKQLLVKTKKELADLRQAETDHLMLQASLKGELEASQQQVEVYKIQLAEVTAEKHKAHEHLKASADQHQRTLGAYQQRVSALQEECREARAEQAAVTSEFESYKVRVHNVLKQQKNKSVSQTEAEGAKQEREHLEMLIDQLKLKLQDTQNSLQISTSELQALQCEHCALLERHNRVLQEAVGKEAELREKLCSVQSENSALKAEHAQIVDQLTAQHEALRAGFREQVRQLQEEHRRTVETLQQQLCRLEAQLLEPRSEPATRSPASSQQPLRSLRERRSADLPFLDVQVTAREEGEGMETTDLEHGSPASTPAQSLEQLLSSPEARLEPPAWHNEFTKEELVQKLNSTTKSADHLNGLLRETEATNAILMEQIKLLKSEVRRLERNQEREKSAANLEYLKNVLLQFILLKPGSERARLLPVVDTMLQLSPEEKTRLAAAAQGEEESGSRSSGWASYLHSWSGLR", "length": 1684, "header": "tr|E1BB16-1|E1BB16_BOVIN Isoform 1 of GRIP and coiled-coil domain containing 2 OS=Bos taurus OX=9913 GN=GCC2 PE=4 SV=2 CANONICAL=E1BB16-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LMU5-1", "url": "https://www.uniprot.org/uniprotkb/E1BB16/entry#A0A3Q1LMU5-1", "sequence": { "sequence": "MEEPVHEGVASPAARGTGKSKLEALPKEDLIKFAKKQMMLIQKTKLRCTELEKEVEELKSKLVAGGADIIKALTERLDAVLLEKAETEQHCVSLKKENIKMKQEVEDSVTKLEDVQKELEQSQRSYGKEIENLRNELTTVHSKYSNDKADWQKEVEEAAKKQLELSEQLRFQSDSEDSVKKLQEEIQKIKLAFEDQILCLQKQLETATNEKEQEITHLQGVIEANCQQYQKDINSLQEELVRLKSTHQEEVKELMCQIETSAKEHEAEVNYLIQLKDNLVRKCEAGEMNIQKYKCELENEGKASGAGQENQVCSLLLQEDSLVEQAVNEKVRHLEDALKELESQHSILKDELTYMNNLKLKLEIDAQHIKDEFFHEREDLEFKINELLLAKEEQGYIIEKLKSELEDANKQFCCTIEQHNKEVQSLKKQHQKEITELNETFLSDSEKEKLTLMFEIQGLKEQCEKLQQEKQEAMLNYEGLREIMEILQTELGESAEKISQEFESMKQQQAFNINELQQKLQTAFNEKDALLETVNYLQKENDNLLSQQECVPELENTIKNLQEKNELYLVSLSQRDTMLQEFEAKISSLTEEKYDFISKMRSSHEEMDNLHKKCEREERLTVELREKVDQTAQYNSELEQKVNELTAGLEETLKEKDEKNRKLEKLTAQLKILSKDQEATSLEVRSLREENSRLSSEKNLLSRDLEALLSQKEGDVTFQEQINKLEEELRLAVRERDNLNKLLENEQVQKLFVKAQLCGFLEQMESKVSQEREEQDVVNILQAMGKSLDKINEEKHNLAFQYDKRIVELEEEIKLLQEEHMVQCEELRSLLTDYEQKKIVLRKELEEALLEKEALQSDLLEMKNASEQTRFENQNLLIQVEEMSQKLCRENENHHKKEKDLIKELENLRPLLEQKESELQDVKAELISLKDSFKKSTSVESDQPSVKEFEEKIGYLEKEAKEKEEKINKLKLVAVKAKKELDSSRKEAQTLQEELQSVRSERDQLSTSMRDLIQGAENYKNLLSEYDKQSEQLDAEKERANNFEHQVEDLTRQLRNLTFQCEKLTSDNEDFLARIETLQSNACLLEAQILEVHKAKAMADKELEAEKLQKEQKIKEHASSVNELEELQLQLQKEKKQLQKTMQELELVRKDAQQTTLMNMEIADYERLMRELNQKLSNKNSKIEDLEQEIKIQKQKQETLQEEMTSLQAVLQQYEEKNTKIKQLLVKTKKELADLRQAETDHLMLQASLKGELEASQQQVEVYKAEQAAVTSEFESYKVRVHNVLKQQKNKSVSQTEAEGAKQEREHLEMLIDQLKLKLQDTQNSLQISTSELQALQCEHCALLERHNRVLQEAVGKEAELREKLCSVQSENSALKAEHAQIVDQLTAQHEALRAGFREQVRQLQEEHRRTVETLQQQLCRLEAQLLEPRSEPATRSPASSQQPLRSLRERRSADLPFLDVQVTAREEGEGMETTDLEHGSPASTPAQSLEQLLSSPEARLEPPAWHNEFTKEELVQKLNSTTKSADHLNGLLRETEATNAILMEQIKLLKSEVRRLERNQEREKSAANLEYLKNVLLQFILLKPGSERARLLPVVDTMLQLSPEEKTRLAAAAQGEEESGSRSSGWASYLHSWSGLR", "length": 1638, "header": "tr|A0A3Q1LMU5-1|E1BB16_BOVIN Computationally mapped isoform of GRIP and coiled-coil domain containing 2 OS=Bos taurus OX=9913 GN=GCC2 PE=4 SV=2 CANONICAL=E1BB16-1" }, "locus": { "chromosome": "11", "start_pos": 44840299, "end_pos": 44806995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075721.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075721.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061233.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061233.2" } ] } }, { "isoform_ac": "A0A3Q1ME69-1", "url": "https://www.uniprot.org/uniprotkb/E1BB16/entry#A0A3Q1ME69-1", "sequence": { "sequence": "MEEPVHEGVASPAARGTGKSKLEALPKEDLIKFAKKQMMLIQKTKLRCTELEKEVEELKSKLVAGGADIIKALTERLDAVLLEKAETEQHCVSLKKENIKMKQEVEDSVTKLEDVQKELEQSQRSYGKEIENLRNELTTVHSKYSNDKADWQKEVEEAAKKQLELSEQLRFQSDSEDSVKKLQEEIQKIKLAFEDQILCLQKQLETATNEKEQEITHLQGVIEANCQQYQKDINSLQEELVRLKSTHQEEVKELMCQIETSAKEHEAEVNYLIQLKDNLVRKCEAGEMNIQKYKCELENEGKASGAGQENQVCSLLLQEDSLVEQAVNEKVRHLEDALKELESQHSILKDELTYMNNLKLKLEIDAQHIKDEFFHEREDLEFKINELLLAKEEQGYIIEKLKSELEDANKQFCCTIEQHNKEVQSLKKQHQKEITELNETFLSDSEKEKLTLMFEIQGLKEQCEKLQQEKQEAMLNYEGLREIMEILQTELGESAEKISQEFESMKQQQAFNINELQQKLQTAFNEKDALLETVNYLQKENDNLLSQQECVPELENTIKNLQEKNELYLVSLSQRDTMLQEFEAKISSLTEEKYDFISKMRSSHEEMDNLHKKCEREERLTVELREKVDQTAQYNSELEQKVNELTAGLEETLKEKDEKNRKLEKLTAQLKILSKDQEATSLEVRSLREENSRLSSEKNLLSRDLEALLSQKEGDVTFQEQINKLEEELRLAVRERDNLNKLLENEQVQKLFVKAQLCGFLEQMESKVSQEREEQDVVNILQAMGKSLDKINEEKHNLAFQYDKRIVELEEEIKLLQEEHMVQCEELRSLLTDYEQKKIVLRKELEEALLEKEALQSDLLEMKNASEQTRFENQNLLIQVEEMSQKLCRENENHHKKEKDLIKELENLRPLLEQKESELQDVKAELISLKDSFKKSTSVESDQPSVKEFEEKIGYLEKEAKEKEEKINKLKLVAVKAKKELDSSRKEAQTLQEELQSVRSERDQLSTSMRDLIQGAENYKCEKLTSDNEDFLARIETLQSNACLLEAQILEVHKAKAMADKELEAEKLQKEQKIKEHASSVNELEELQLQLQKEKKQLQKTMQELELVRKDAQQTTLMNMEIADYERLMRELNQKLSNKNSKIEDLEQEIKIQKQKQETLQEEMTSLQAVLQQYEEKNTKIKQLLVKTKKELADLRQAETDHLMLQASLKGELEASQQQVEVYKIQLAEVTAEKHKAHEHLKASADQHQRTLGAYQQRVSALQEECREARAEQAAVTSEFESYKVRVHNVLKQQKNKSVSQTEAEGAKQEREHLEMLIDQLKLKLQDTQNSLQISTSELQALQCEHCALLERHNRVLQEAVGKEAELREKLCSVQSENSALKAEHAQIVDQLTAQHEALRAGFREQVRQLQEEHRRTVETLQQQLCRLEAQLLEPRSEPATRSPASSQQPLRSLRERRSADLPFLDVQVTAREEGEGMETTDLEHGSPASTPAQSLEQLLSSPEARLEPPAWHNEFTKEELVQKLNSTTKSADHLNGLLRETEATNAILMEQIKLLKSEVRRLERNQEREKSAANLEYLKNVLLQFILLKPGSERARLLPVVDTMLQLSPEEKTRLAAAAQGEEESGSRSSGWASYLHSWSGLR", "length": 1644, "header": "tr|A0A3Q1ME69-1|E1BB16_BOVIN Computationally mapped isoform of GRIP and coiled-coil domain containing 2 OS=Bos taurus OX=9913 GN=GCC2 PE=4 SV=1 CANONICAL=E1BB16-1" }, "locus": { "chromosome": "11", "start_pos": 44840299, "end_pos": 44806995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071121.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071121.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068778.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068778.1" } ] } }, { "isoform_ac": "A0A3Q1NBL7-1", "url": "https://www.uniprot.org/uniprotkb/E1BB16/entry#A0A3Q1NBL7-1", "sequence": { "sequence": "MEEPVHEGVASPAARGTGKSKALTERLDAVLLEKAETEQHCVSLKKENIKMKQEVEDSVTKLEDVQKELEQSQRSYGKEIENLRNELTTVHSKYSNDKADWQKEVEEAAKKQLELSEQLRFQSDSEDSVKKLQEEIQKIKLAFEDQILCLQKQLETATNEKEQEITHLQGVIEANCQQYQKDINSLQEELVRLKSTHQEEVKELMCQIETSAKEHEAEVNYLIQLKDNLVRKCEAGEMNIQKYKCELENEGKASGAGQENQVCSLLLQEDSLVEQAVNEKVRHLEDALKELESQHSILKDELTYMNNLKLKLEIDAQHIKDEFFHEREDLEFKINELLLAKEEQGYIIEKLKSELEDANKQFCCTIEQHNKEVQSLKKQHQKEITELNETFLSDSEKEKLTLMFEIQGLKEQCEKLQQEKQEAMLNYEGLREIMEILQTELGESAEKISQEFESMKQQQAFNINELQQKLQTAFNEKDALLETVNYLQKENDNLLSQQECVPELENTIKNLQEKNELYLVSLSQRDTMLQEFEAKISSLTEEKYDFISKMRSSHEEMDNLHKKCEREERLTVELREKVDQTAQYNSELEQKVNELTAGLEETLKEKDEKNRKLEKLTAQLKILSKDQEATSLEVRSLREENSRLSSEKNLLSRDLEALLSQKEGDVTFQEQINKLEEELRLAVRERDNLNKLLENEQVQKLFVKAQLCGFLEQMESKVSQEREEQDVVNILQAMGKSLDKINEEKHNLAFQYDKRIVELEEEIKLLQEEHMVQCEELRSLLTDYEQKKIVLRKELEEALLEKEALQSDLLEMKNASEQTRFENQNLLIQVEEMSQKLCRENENHHKKEKDLIKELENLRPLLEQKESELQDVKAELISLKDSFKKSTSVESDQPSVKEFEEKIGYLEKEAKEKEEKINKLKLVAVKAKKELDSSRKEAQTLQEELQSVRSERDQLSTSMRDLIQGAENYKNLLSEYDKQSEQLDAEKERANNFEHQVEDLTRQLRNLTFQCEKLTSDNEDFLARIETLQSNACLLEAQILEVHKAKAMADKELEAEKLQKEQKIKEHASSVNELEELQLQLQKEKKQLQKTMQELELVRKDAQQTTLMNMEIADYERLMRELNQKLSNKNSKIEDLEQEIKIQKQKQETLQEEMTSLQAVLQQYEEKNTKIKQLLVKTKKELADLRQAETDHLMLQASLKGELEASQQQVEVYKIQLAEVTAEKHKAHEHLKASADQHQRTLGAYQQRVSALQEECREARAEQAAVTSEFESYKVRVHNVLKQQKNKSVSQTEAEGAKQEREHLEMLIDQLKLKLQDTQNSLQISTSELQALQCEHCALLERHNRVLQEAVGKEAELREKLCSVQSENSALKAEHAQIVDQLTAQHEALRAGFREQVRQLQEEHRRTVETLQQQLCRLEAQLLEPRSEPATRSPASSQQPLRSLRERRSADLPFLDVQVTAREEGEGMETTDLEHGSPASTPAQSLEQLLSSPEARLEPPAWHNEFTKEELVQKLNSTTKSADHLNGLLRETEATNAILMEQIKLLKSEVRRLERNQEREKSAANLEYLKNVLLQFILLKPGSERARLLPVVDTMLQLSPEEKTRLAAAAQGEEESGSRSSGWASYLHSWSGLR", "length": 1634, "header": "tr|A0A3Q1NBL7-1|E1BB16_BOVIN Computationally mapped isoform of GRIP and coiled-coil domain containing 2 OS=Bos taurus OX=9913 GN=GCC2 PE=4 SV=2 CANONICAL=E1BB16-1" }, "locus": { "chromosome": "11", "start_pos": 44840299, "end_pos": 44806995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068648.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068648.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068727.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068727.2" } ] } }, { "isoform_ac": "E1BB16-1", "url": "https://www.uniprot.org/uniprotkb/E1BB16/entry#E1BB16-1", "sequence": { "sequence": "MEEPVHEGVASPAARGTGKSKLEALPKEDLIKFAKKQMMLIQKTKLRCTELEKEVEELKSKLVAGGADIIKALTERLDAVLLEKAETEQHCVSLKKENIKMKQEVEDSVTKLEDVQKELEQSQRSYGKEIENLRNELTTVHSKYSNDKADWQKEVEEAAKKQLELSEQLRFQSDSEDSVKKLQEEIQKIKLAFEDQILCLQKQLETATNEKEQEITHLQGVIEANCQQYQKDINSLQEELVRLKSTHQEEVKELMCQIETSAKEHEAEVNYLIQLKDNLVRKCEAGEMNIQKYKCELENEGKASGAGQENQVCSLLLQEDSLVEQAVNEKVRHLEDALKELESQHSILKDELTYMNNLKLKLEIDAQHIKDEFFHEREDLEFKINELLLAKEEQGYIIEKLKSELEDANKQFCCTIEQHNKEVQSLKKQHQKEITELNETFLSDSEKEKLTLMFEIQGLKEQCEKLQQEKQEAMLNYEGLREIMEILQTELGESAEKISQEFESMKQQQAFNINELQQKLQTAFNEKDALLETVNYLQKENDNLLSQQECVPELENTIKNLQEKNELYLVSLSQRDTMLQEFEAKISSLTEEKYDFISKMRSSHEEMDNLHKKCEREERLTVELREKVDQTAQYNSELEQKVNELTAGLEETLKEKDEKNRKLEKLTAQLKILSKDQEATSLEVRSLREENSRLSSEKNLLSRDLEALLSQKEGDVTFQEQINKLEEELRLAVRERDNLNKLLENEQVQKLFVKAQLCGFLEQMESKVSQEREEQDVVNILQAMGKSLDKINEEKHNLAFQYDKRIVELEEEIKLLQEEHMVQCEELRSLLTDYEQKKIVLRKELEEALLEKEALQSDLLEMKNASEQTRFENQNLLIQVEEMSQKLCRENENHHKKEKDLIKELENLRPLLEQKESELQDVKAELISLKDSFKKSTSVESDQPSVKEFEEKIGYLEKEAKEKEEKINKLKLVAVKAKKELDSSRKEAQTLQEELQSVRSERDQLSTSMRDLIQGAENYKNLLSEYDKQSEQLDAEKERANNFEHQVEDLTRQLRNLTFQCEKLTSDNEDFLARIETLQSNACLLEAQILEVHKAKAMADKELEAEKLQKEQKIKEHASSVNELEELQLQLQKEKKQLQKTMQELELVRKDAQQTTLMNMEIADYERLMRELNQKLSNKNSKIEDLEQEIKIQKQKQETLQEEMTSLQAVLQQYEEKNTKIKQLLVKTKKELADLRQAETDHLMLQASLKGELEASQQQVEVYKIQLAEVTAEKHKAHEHLKASADQHQRTLGAYQQRVSALQEECREARAEQAAVTSEFESYKVRVHNVLKQQKNKSVSQTEAEGAKQEREHLEMLIDQLKLKLQDTQNSLQISTSELQALQCEHCALLERHNRVLQEAVGKEAELREKLCSVQSENSALKAEHAQIVDQLTAQHEALRAGFREQVRQLQEEHRRTVETLQQQLCRLEAQLLEPRSEPATRSPASSQQPLRSLRERRSADLPFLDVQVTAREEGEGMETTDLEHGSPASTPAQSLEQLLSSPEARLEPPAWHNEFTKEELVQKLNSTTKSADHLNGLLRETEATNAILMEQIKLLKSEVRRLERNQEREKSAANLEYLKNVLLQFILLKPGSERARLLPVVDTMLQLSPEEKTRLAAAAQGEEESGSRSSGWASYLHSWSGLR", "length": 1684, "header": "tr|E1BB16-1|E1BB16_BOVIN Isoform 1 of GRIP and coiled-coil domain containing 2 OS=Bos taurus OX=9913 GN=GCC2 PE=4 SV=2 CANONICAL=E1BB16-1" }, "locus": { "chromosome": "11", "start_pos": 44840299, "end_pos": 44806995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021345.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021345.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021345.5", "url": "https://www.ensembl.org/id/ENSBTAP00000021345.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1531, "start_aa": "Thr", "end_pos": 1531, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1531", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539484", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539484", "resource": "KEGG Pathway" }, { "id": "R-BTA-6811440", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "resource": "Reactome", "description": "Retrograde transport at the Trans-Golgi-Network" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YKB0-1", "protein_name": "GRIP and coiled-coil domain containing 2", "gene_name": "GCC2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEVQDGGQEMVASPATPGSGKSKLDTLPKEDLIKFAKKQMMLIQKVKSRCTELEREIEELRSKPATGGADDIIQALTERLDVVLLEKAESQQQCVALKKENLQRKQEAEAAVARTEELQKQLEQSNTDSLEEIKALKNELINAQSKYNEDLTKLKTELEEKEKKQMELVEQIKCCSDNQEEVKRLQDYVQKIKSTYEDQILCLNKQLETVNDDKNKEIATLQETIRSNSQCYHNEISSLSEELKQLKIAHQEEVSELMHHIEISSKENEEKQNQINQLQHSLAEADLIKEKNVKDEAYGHTEQHKHDFEQLKQVLNKNIEDKVNVLDMQEEPCVEAKMEEKIRHLECSLGDLQSQHSILKDELTYMSNVKLKLEEEIHRIKDEYFHEREDLDFKINELQLIKEDYCCVIEKLKLELQTARHHYETTAEEHKLETQNLREQHEREISELNKTLLSSSEKEKMALVLEMQELKDQLEKLTLEKEDAVLSYDSLRETLETIQTELGESAGKISQQFESMKQQQASDVSELQQKLRAAFNEKDGLLETVNRLQAETQKLSSYQLEIEELKHKIVSLQEENDTITSCVHQKEASIKELEEKTIALANQNKDILNEVKCSGEEREALQERCKQEQGKVQELQQEVDVVNQYNSDLKKKLEELTERLNDALTGKNENTKMLEQLENQIDTLVRERENLSSEVSALREENKKIVQEKEELSKELEKITYEKDGWLVLKEQFENLEKKLQMVTAEKDHISSLLESEQVHKSLVRTQLYHILEQVGYSISDSNEECDFLNLLQIANEHLIKMKEKQCFALQNEEKVLHLQREIERLEEENATQYTEHRSLIQDFGREKDHLKEELEEVLSEKEALQHDIQELRSAGEKATIENQDLLAKIEEMSEKLAFYESQIQEQQKGSKAQEELNFILEQKETELRNVKDELSSLKTVMESLTGKNDEQSSVAELQEKIERLEKESAEKGEKLNKMKAVAVRAKKELDTSRKEMQALREELEVVRSEKDQLSASMKDVIQGAESYKNLLMEYDKQGEELDSEKGRANSLERQIDDLTRQLQVSSQQHDQLHSANEDLLARVETLQCNSKLLEAQILELQKVKAKAEKELEAEKLLKEQKMKEHSGTVRELEELQMQLQKEKKYLQKIMQELELAKKDAQKSTLMDMEIADYEKLVKELNQKITDKDSRIEDLEQETGIQKQKQETLQEEIKSLQSTMQEDEERNAKIKQLLVKTKKELADSKRAENDHLMLQASLKGELEASQQQVEAFKIQVAALTSEKHKVQEHLRTSSEQHQRTLNAYQQKIATLREECRAAQAEQASVTSEFESYKVRVHNVLKQQKNKTASQTETEGAKQEREQLETVIEQLKAKLQETQHNLQINAAEFQALQSEHDTLLERHNKMLQETVAKEAELREKFCTIQSENMVMKTEHAQALSQLTAQNEALRNNFRDQVRNLQEEHRKTVETLQQQLSRVEAQLFQLKSEPSTRGPAVSNPVPKNLRERRNTDLPVLDVHAIAREEGEGMETTDTESVSSASTYIPSLEQLLNSPETKPETSQWQTELTKDELIEKLSTTTKSADHLNELLRESEATNAILMEQIKLLKSEIRRLERNQEREKSVANLEYLKNVLLQFIFLKSGSERERLLPVIDTMLQLSPEEKGKLVAIAQGPKYTRSTLSMQDTEAVRTLAFTIPLVFHCASLTLSYISSFLTASASEVK", "length": 1720 }, "evidence": [ { "id": "E1BB16", "url": "https://omabrowser.org/oma/group/E1BB16/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZZL9-1", "protein_name": "GRIP and coiled-coil domain-containing protein 2", "gene_name": "Gcc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEDSAQDAVTAAPSGTPKSKLETLPREDLIKFAKKQMMLLQKAKARCTELDKEVEELKSKPVDGGTDDMIKVLTERLDALLLEKAETEQQCLCLKKENIKMKQEVEDSVTKLEETQKEFEQSHRNYVREMESVKNELIAVHSEHSKEKAALQRDLEGAVHRQAELLEQLKSQSDSEDNVKKLQEEIQNITAAFEEQTSCLQKQLEATSDEKQQEIIHLQKVIEDNAQHYQKDINTFQEEIVQLRATHKEEVNELMSQMETLAKEHEAAVNKLKENRVTLCETSETIPENYQCESESLNEDTSDASQENQKCSVALQEDPFAEHTVYDKVRQLEDSLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQSYVVEKLKYEREDLNRQLCCTVEQHNKEIQRLQEHHQKEISELSETFMSGSEKEKLALMFEIQGLKEQCENLQHEKQEVVLNYESLREMMEILQTELGESAGKISQEFETMKQQQASDVHELQQKLRTAFNEKDALLETINRLQGENEKLLSQELVSELESTMKNLKADNSMYLASLGQKDTLLQELEAKISSLAEEKDDFISKIKTSREEIDDLHQKWEREQKLSVELREAAEQAAQHNSELRQRVSELTGKLDEILREKSQNDQNIMVQMKTMTEDQEALSSKIKSLYEENNRLHSEKVQLSRDLEALQSQQDFAYKEHVAEFEKKLQLMVEERDDLNKLLENEQLQKSFVKTQLYEFLKQMRPSILEDNEEEDVVTVLKAVGESLVTVKEEKHNLVFEYDARVLELERRIKCLQEESVVQCEELRALVRDSEQEKILLRKELDEVTSTKEALQCDILEMKNTNEKTSLENQTLSTRVEELSRSLHSKNEVHNEKDLVIEHENLRLSLEQRESELQDVRAELMLLKDSLEKSPSVKNDQLSLVKELEEKIESLEKESKDKDEKISKIKLVAVRAKKELDSNRKEAQTLRDELESVQSEKDRLSASMKEFIQGAESYKNLLLEYDKQSEQLDVEKERANNFEHHIEDLTKQLRDSTCQYEKLTSDNEDLLARIETLQANARLLEAQILEVQRAKGVVEKELEAEKLQKEQKIKEHVSTTNELEELQLQFQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNSKIEDLEQEMKIQKQKQETLQEEMTSLQSSVQHYEEKNAQIKQLLVKTKKELADAKQAETDHLLLQASLKGELEASQQQVEVYKIQLAEMTSEKHKIHEHLKTSAEQHQRTLSAYQQRVVALQEESRTAKAEQAAVTSEFENYKVRVHNVLKQQKNKSVSQAETEGAKQEREHLEMLIDQLKIKLQDSQNSLQISVSEFQTLQSEHDTLLERHNRMLQETVTKEAELREKLCSAQSENTMLKSEHAQTMCQLTSQNEALRNSFRDQVRHLQDEHRKTVETLQHQLSKVETQLFQLKSEPPTKSPASSHQPSKSLRERRTTDLPLLDMHTVTREEGEGMETTDSESVSSAGTHIQSLEQLLSSPDSKLERLTEASLWHTEFTKEELAEKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSVANLEYLKNVLLRFIFLKPGSERERLLPVIDTMLQLSPEEKGKLATVAQGEEESASRSSGWASYLHSWSGLR", "length": 1679 }, "evidence": [ { "id": "E1BB16", "url": "https://omabrowser.org/oma/group/E1BB16/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HJ09-1", "protein_name": "GRIP and coiled-coil domain-containing protein 2", "gene_name": "Gcc2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEDPVQDGVAAAPSGTGKSKLETLPREDLIKFAKKQMMLLQKAKARCTELDKEIEELKSKPVDGGTDDIIKVLTERLDTLLLDKAETEQQCLCLKKENIKMKQEVEDSVTKLEDTHKEFEQSQRNYVNEIESLKNELMAVQSEHSKEKASLQQELEEAANKQLELLEQLKSQSDSEDRVKQLQEEIHNITARFEEQVLCLQKQLEATNDEKKQEIIHLQKVIEENTRQYQKDIDTFQEEILQLRAAHKEEVNELMSQMEILAKEHEAEINKLKDNRVQQCEGSENNQEKYHCELENLNEGTSDSKQENQHHSLPLQEDTFAEQTVNDKVRQLEDSLKELESQHSILKDEVTYMNNLKLKLEMEAQHIKDEFFHEREDLEFKINELLLAKEEQGYIVEKLKYEQEDLNRQLCCAVEQHNKEIQHLREVHQKEISELSETFMSGSEKEKLALMFEIQGLKEQCENLHHEKQEAILNYESLREMMEILQTELGESAGKISQEFETMKQQQASDVHELQQKLRTAFNEKDALLETVNCLQRENKKLLSHQELVPELESTIKSLKADNSMYLASLGQKDTVLQELEAKISSLAEEKDEFVSKMKTCHAEIDNLHQKWEREQRLTIELREAAEQTTQHNSELRQRVDELTGKLDEILRERSQNDQSIMVQIKTMTEDQEALSSKIQSLYEENDKLLTEKVQLSRDLETLQSQKDFAHKEHVTELEEKLQLMVEERDNLNKVFENEQVQKSFVKTQLYGYLKQMGPNILEENEEEDVVKVLQAVGESLAKIKEEKHNLVFEYDERVLELERKIKCLQEESVAQHEELTALLKDSEQEKILLRKELEETTSSKETLQLDLLEMKNANEKTSLENQTLLAQVEELFQTLHSQNEVRNEKLLVIEHENLKLLLEQRESELQDLRAELIQLKDSLEKSPSVKNDQLSLVKELEEKIGSLEKESKDKDEKISKIKLVAVKAKKELDSNKKEAQTLREELESVRSEKDRLSASMKEFIQGAENYKNLLLEYDKQSEQLDVEKERANNFEHHIEDLTKQLRNSTCQCEKLNSDNEDLLARIETLQSNAKLLEAQILEVQKAKGIVDKELEAEKLQKEQKIKEHVSTVNELEGLQLQFEKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNSKIEDLEQEIKIQKQKQENLQEEMTSLQTSVQHSEEKNTKIKQLLVKTKKELADSKQAEADHLLLQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVAALQEESRTAKAEQAAVTSEFESYKVRVHNVLKQQKNKSVSQAETEGAKQEREHLEMLIDQLKIKLQDSQNSLQINVSELQTLQSEHDTLLERHNRMLQETVTKEAELREKLCSVQSENTVMKSEHAQTVCQLTAQNEALRNSFRDQVRHLQDEHRKTVETLQHQLSKVEAQLFQLKSEPSTRSPASSHQPLKNPRERRNTDLPLLDMHTVAREEGEGMETTDSESVSSAGTHIPSLEQLLSSPDTKLEQHLAEPSLWHAEFTKEELAEKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSVANLEYLKNVLLRFIFLKPGSERERLLPVIDTMLQLSPEEKGKLATVAQGEEESASRSSGWASYLHSWSGLR", "length": 1681 }, "evidence": [ { "id": "E1BB16", "url": "https://omabrowser.org/oma/group/E1BB16/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8CHG3-1", "protein_name": "GRIP and coiled-coil domain-containing protein 2", "gene_name": "Gcc2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEDSAPDAVAAAPSGTPKSKLETLPREDLIKFAKKQMMLLQKAKARCTELDKEVEELKSKPVDGGTDDIIKVLTERLDALLLEKAETEQQCLCLKKENVKMKQEVEDSVTKLEETHKEFEQSHRNYVKEIESCKNELMAVHSEHSKETAILQKELEEAVHKQVELREQLKSQSDSEDNVRKLQEEIQNITAAFEEQISCLEKKLEATSDEKQQEIIHLQKVIEDKAQHYQKDINTFQAEILQLRATHKEEVTELMSQIETSAKEHEAEINKLKENRVTQCEASENIPEKYQCESENLNEVASDASPESQNCSVALQEDPSAEQTVCDKVRQLEDSLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGYVVEKLKYEREDLNRQLCCAVEQHNKEIQRLQEHHQKEVSELSETFISGSEKEKLALMFEIQGLKEQCENLQHEKQEVVLNYESLREMMEILQTELGESAGKISQEFETMKQQQASDVHELQQKLRSAFNEKDALLETVNRLQGENEKLLSQQELVPELESTIKNLQADNSMYLASLGQKDTMLQELEAKISSLAKEKDDFISKIKTSHEEMDDLHQKWEREQRLSVELREAAGQAAQHNSELRQRVSELTGKLDELVREKSQNDQSITVQMKTMTEDQEALSSKIKSLYEENNRLHSEKAQLSRDLEALQAQQDFAHKEHVAEFEKKLQLMVEERDDLNKLLENEQVQKSFVKTQLYEYLKQLRASILEENEEEDVVKLIQAVGESLVKVKEEEHNLVFEYDARVLELENKIKCLQEDSAVQCEELRTLVRDSEQEKILLRKELDAVTSAKEALQLDLLEMKNTNEKASLENQTLSTQVEELSQTLHSRNEVHDEKVLVIEHENLRLLLKQRESELQDVRAELILLKDSLEKSPSVKNDQLSLVKELEEKIESLEKESKDKDEKISKIKLVAVKAKKELDSNRKEAQTLREELESVRSEKDRLSASMKEFLQGAESYKSLLLEYDKQSEQLDVEKERAHNFERHIEDLTKQLRNSTCQYERLTSDNEDLLARIETLQANAKLLEAQILEVQKAKGVVEKELDAEKLQKEQKIKEHVSTVNELEELQLQFQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNSTIEDLEQEMKIQKEKQETLQEEITSLQSSVQHYEEKNTKIKQLLVKTKKELADAKQAETDHLLLQASLKGELEASQQQVEVYKIQLAEMTSEKHKIHEHLKTSAEQHQRTLSAYQQRVVALQEESRAAKAEQAAVTSEFESYKVRVHNVLKQQKNKSVSQVETEGAKQEREHLEMLIDQLKIKLQDSQNSLQISVSEYQTLQAEHDTLLERHNRMLQETVTKEAELREKLCSVQSENTMMKSEHSQTMCQLTSQNEALRTSFRDQVRHLQDEHRKTVETLQHQLSKLEAQLFQLKSEPSTRSPASSHQPSKSLRERRTTDLPLLDMHTVAREEGEGMETTDSESVSSAGTHIQSLEQLLSSPDTKLERLAETSLWHNEFTKEELAEKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSVANLEYLKNVLLRFIFLKPGSERERLLPVIDTMLQLSPEEKGKLATVAQGEEESASRSSGWASYLHSWSGLR", "length": 1680 }, "evidence": [ { "id": "E1BB16", "url": "https://omabrowser.org/oma/group/E1BB16/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IWJ2-1", "protein_name": "GRIP and coiled-coil domain-containing protein 2", "gene_name": "GCC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEDLVQDGVASPATPGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKQKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEENASRSSGWASYLHSWSGLR", "length": 1684 }, "evidence": [ { "id": "E1BB16", "url": "https://omabrowser.org/oma/group/E1BB16/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BB16", "url": "https://www.uniprot.org/uniprotkb/E1BB16" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BB16", "url": "https://www.uniprot.org/uniprotkb/E1BB16" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BB16", "url": "https://www.uniprot.org/uniprotkb/E1BB16" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "E1BB16", "url": "https://www.uniprot.org/uniprotkb/E1BB16" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BB16", "url": "https://www.uniprot.org/uniprotkb/E1BB16" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "protein targeting to lysosome", "id": "GO:0006622", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006622", "evidence": [ { "database": "UniProtKB", "id": "E1BB16", "url": "https://www.uniprot.org/uniprotkb/E1BB16" } ], "pmid": "" }, { "name": "Golgi ribbon formation", "id": "GO:0090161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090161", "evidence": [ { "database": "UniProtKB", "id": "E1BB16", "url": "https://www.uniprot.org/uniprotkb/E1BB16" } ], "pmid": "" }, { "name": "protein localization to Golgi apparatus", "id": "GO:0034067", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034067", "evidence": [ { "database": "UniProtKB", "id": "E1BB16", "url": "https://www.uniprot.org/uniprotkb/E1BB16" } ], "pmid": "" }, { "name": "microtubule anchoring", "id": "GO:0034453", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034453", "evidence": [ { "database": "UniProtKB", "id": "E1BB16", "url": "https://www.uniprot.org/uniprotkb/E1BB16" } ], "pmid": "" }, { "name": "microtubule organizing center organization", "id": "GO:0031023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031023", "evidence": [ { "database": "UniProtKB", "id": "E1BB16", "url": "https://www.uniprot.org/uniprotkb/E1BB16" } ], "pmid": "" }, { "name": "late endosome to Golgi transport", "id": "GO:0034499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034499", "evidence": [ { "database": "UniProtKB", "id": "E1BB16", "url": "https://www.uniprot.org/uniprotkb/E1BB16" } ], "pmid": "" }, { "name": "regulation of protein exit from endoplasmic reticulum", "id": "GO:0070861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070861", "evidence": [ { "database": "UniProtKB", "id": "E1BB16", "url": "https://www.uniprot.org/uniprotkb/E1BB16" } ], "pmid": "" }, { "name": "recycling endosome to Golgi transport", "id": "GO:0071955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071955", "evidence": [ { "database": "UniProtKB", "id": "E1BB16", "url": "https://www.uniprot.org/uniprotkb/E1BB16" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1056, "end_pos": 1058, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1336, "end_pos": 1338, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1566, "end_pos": 1568, "annotation": "n_glycosylation_sequon" }, { "start_pos": 438, "end_pos": 440, "annotation": "n_glycosylation_sequon" }, { "start_pos": 864, "end_pos": 866, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BB16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB16" }, { "id": "PS50913", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50913" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GRIP", "eco_id": "ECO_0000259", "start_pos": 1609, "end_pos": 1659, "start_aa": "Arg", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1531 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1056, "end_pos": 1058 }, { "start_pos": 1336, "end_pos": 1338 }, { "start_pos": 1566, "end_pos": 1568 }, { "start_pos": 438, "end_pos": 440 }, { "start_pos": 864, "end_pos": 866 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": 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"total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BC13-1", "uniprot_ac": "E1BC13", "uniprot_id": "E1BC13_BOVIN", "mass": { "chemical_mass": 81578.0, "monoisotopic_mass": 81578.0 }, "refseq": {}, "gene_names": [ { "name": "KCNC3", "type": "recommended", "evidence": [ { "id": "E1BC13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC13" } ] } ], "protein_names": [ { "name": "Potassium voltage-gated channel subfamily C member 3", "type": "synonym", "evidence": [ { "id": "E1BC13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC13/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BC13", "url": "https://www.uniprot.org/uniprotkb/E1BC13" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCNC3", "url": "https://www.uniprot.org/uniprotkb/E1BC13", "locus": { "chromosome": "18", "start_pos": 56494454, "end_pos": 56506505, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039935", "url": "https://www.ensembl.org/id/ENSBTAG00000039935" } ] } } ], "crossref": [ { "id": "E1BC13", "url": "https://alphafold.ebi.ac.uk/entry/E1BC13", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039935", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039935", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18414", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18414", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003968", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003968", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028325", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028325", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11537", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11537:SF184", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537:SF184", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1296072", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "29463", "url": "https://www.rhea-db.org/rhea/29463", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LQ61", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQ61-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ61-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC13", "url": "https://www.uniprot.org/uniprotkb/E1BC13", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC13-1", "url": "https://www.uniprot.org/uniprotkb/E1BC13-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSSVCVSSFRGRQGASKQQPAPPPQPFESPPPPPPLLQQQQPAQPGPAASPAGPPAPRGPGGRRAEPCPGLPAAAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPSGAANAANAAGAHDAGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENVTNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPNDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPPPLPPHHGSGGISPPPPITPPSMGVTVAGAYPPGPHTHPGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVVEINRADPRPNGDPAAAALAHEDCPAIDQPAMSPEDKSPITPGSRGRYGRDRACFLLTDYAPSPDGSIRKGYEKSRSLSSIAGLSGVSLRLAPLATPPGSPRAARRAPPTLPSIL", "length": 768, "header": "tr|E1BC13-1|E1BC13_BOVIN Isoform 1 of Potassium voltage-gated channel subfamily C member 3 OS=Bos taurus OX=9913 GN=KCNC3 PE=4 SV=4 CANONICAL=E1BC13-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQ61-1", 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member 3 OS=Bos taurus OX=9913 GN=KCNC3 PE=4 SV=1 CANONICAL=E1BC13-1" }, "locus": { "chromosome": "18", "start_pos": 56506091, "end_pos": 56498389, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077411.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077411.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057096.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057096.1" } ] } }, { "isoform_ac": "E1BC13-1", "url": "https://www.uniprot.org/uniprotkb/E1BC13/entry#E1BC13-1", "sequence": { "sequence": "MLSSVCVSSFRGRQGASKQQPAPPPQPFESPPPPPPLLQQQQPAQPGPAASPAGPPAPRGPGGRRAEPCPGLPAAAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPSGAANAANAAGAHDAGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENVTNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPNDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPPPLPPHHGSGGISPPPPITPPSMGVTVAGAYPPGPHTHPGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVVEINRADPRPNGDPAAAALAHEDCPAIDQPAMSPEDKSPITPGSRGRYGRDRACFLLTDYAPSPDGSIRKGYEKSRSLSSIAGLSGVSLRLAPLATPPGSPRAARRAPPTLPSIL", "length": 768, "header": "tr|E1BC13-1|E1BC13_BOVIN Isoform 1 of Potassium voltage-gated channel subfamily C member 3 OS=Bos taurus OX=9913 GN=KCNC3 PE=4 SV=4 CANONICAL=E1BC13-1" }, "locus": { "chromosome": "18", "start_pos": 56506091, "end_pos": 56494457, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020819.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020819.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020819.6", "url": "https://www.ensembl.org/id/ENSBTAP00000020819.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 601, "start_aa": "Thr", "end_pos": 601, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr601", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 694, "start_aa": "Thr", "end_pos": 694, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr694", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 749, "start_aa": "Thr", "end_pos": 749, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr749", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-1296072", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "resource": "Reactome", "description": "Voltage gated Potassium channels" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "E1BC13", "url": "https://www.uniprot.org/uniprotkb/E1BC13" } ], "pmid": "" }, { "name": "protein tetramerization", "id": "GO:0051262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051262", "evidence": [ { "database": "UniProtKB", "id": "E1BC13", "url": "https://www.uniprot.org/uniprotkb/E1BC13" } ], "pmid": "" }, { "name": "action potential", "id": "GO:0001508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001508", "evidence": [ { "database": "UniProtKB", "id": "E1BC13", "url": "https://www.uniprot.org/uniprotkb/E1BC13" } ], "pmid": "" }, { "name": "cortical actin cytoskeleton organization", "id": "GO:0030866", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030866", "evidence": [ { "database": "UniProtKB", "id": "E1BC13", "url": "https://www.uniprot.org/uniprotkb/E1BC13" } ], "pmid": "" }, { "name": "potassium ion transmembrane transport", "id": "GO:0071805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "evidence": [ { "database": "UniProtKB", "id": "E1BC13", "url": "https://www.uniprot.org/uniprotkb/E1BC13" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "voltage-gated potassium channel complex", "id": "GO:0008076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008076", "evidence": [ { "database": "UniProtKB", "id": "E1BC13", "url": "https://www.uniprot.org/uniprotkb/E1BC13" } ], "pmid": "" }, { "name": "presynaptic membrane", "id": "GO:0042734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042734", "evidence": [ { "database": "UniProtKB", "id": "E1BC13", "url": "https://www.uniprot.org/uniprotkb/E1BC13" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "E1BC13", "url": "https://www.uniprot.org/uniprotkb/E1BC13" } ], "pmid": "" }, { "name": "axon terminus", "id": "GO:0043679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043679", "evidence": [ { "database": "UniProtKB", "id": "E1BC13", "url": "https://www.uniprot.org/uniprotkb/E1BC13" } ], "pmid": "" }, { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "E1BC13", "url": "https://www.uniprot.org/uniprotkb/E1BC13" } ], "pmid": "" }, { "name": "neuronal cell body membrane", "id": "GO:0032809", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032809", "evidence": [ { "database": "UniProtKB", "id": "E1BC13", "url": "https://www.uniprot.org/uniprotkb/E1BC13" } ], "pmid": "" }, { "name": "dendrite membrane", "id": "GO:0032590", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032590", "evidence": [ { "database": "UniProtKB", "id": "E1BC13", "url": "https://www.uniprot.org/uniprotkb/E1BC13" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "voltage-gated potassium channel activity", "id": "GO:0005249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005249", "evidence": [ { "database": "UniProtKB", "id": "E1BC13", "url": "https://www.uniprot.org/uniprotkb/E1BC13" } ], "pmid": "" }, { "name": "delayed rectifier potassium channel activity", "id": "GO:0005251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005251", "evidence": [ { "database": "UniProtKB", "id": "E1BC13", "url": "https://www.uniprot.org/uniprotkb/E1BC13" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 320, "end_pos": 322, "annotation": "n_glycosylation_sequon" }, { "start_pos": 336, "end_pos": 338, "annotation": "n_glycosylation_sequon" }, { "start_pos": 483, "end_pos": 485, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29463", "name": "", "equation": "K(+)(in) = K(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35526-1" ], "evidence": [ { "id": "29463", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29463" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P35526", "gene_name": "CLIC5", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "P35526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35526" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BC13-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 768, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BC13-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BC13" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BC13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC13" }, { "id": "SM00225", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 88, "end_pos": 192, "start_aa": "Gly", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 601, 694, 749 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 320, "end_pos": 322 }, { "start_pos": 336, "end_pos": 338 }, { 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BB24-1", "uniprot_ac": "E1BB24", "uniprot_id": "E1BB24_BOVIN", "mass": { "chemical_mass": 60064.0, "monoisotopic_mass": 60064.0 }, "refseq": { "ac": "NP_001179648", "name": "probable RNA-binding protein 46", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179648" }, "gene_names": [ { "name": "RBM46", "type": "recommended", "evidence": [ { "id": "E1BB24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB24" } ] }, { "name": "RBM46", "type": "synonym", "evidence": [ { "id": "NP_001179648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179648" } ] } ], "protein_names": [ { "name": "Probable RNA-binding protein 46", "type": "recommended", "evidence": [ { "id": "E1BB24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB24/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding motif protein 46", "type": "synonym", "evidence": [ { "id": "E1BB24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB24/entry#names_and_taxonomy" } ] }, { "name": "probable RNA-binding protein 46", "type": "synonym", "evidence": [ { "id": "NP_001179648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179648" } ] } ], "function": [ { "annotation": "Essential for male and female fertility, playing a crucial role in regulating germ cell development by ensuring the proper progression of meiosis prophase I. Regulates mitotic-to-meiotic transition in spermatogenesis by forming a complex with MEIOC and YTHDC2 which recognizes and down-regulates mitotic transcripts for a successful meiotic entry. Required for normal synaptonemal complex formation during meiosis, binding meiotic cohesin subunit mRNAs containing GCCUAU/GUUCGA motifs in their 3'UTRs regions and positively regulating their translation. Required for spermatogonial differentiation in both developing and adult testis.", "evidence": [ { "database": "UniProtKB", "id": "E1BB24", "url": "https://www.uniprot.org/uniprotkb/E1BB24#function" }, { "database": "UniProtKB", "id": "ARBA00059579", "url": "https://www.uniprot.org/uniprotkb/ARBA00059579#function" }, { "database": "UniProtKB", "id": "A0A3Q1LST9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LST9#function" }, { "database": "UniProtKB", "id": "A0AAA9RUB9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUB9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BB24", "url": "https://www.uniprot.org/uniprotkb/E1BB24" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RBM46", "url": "https://www.uniprot.org/uniprotkb/E1BB24", "locus": { "chromosome": "17", "start_pos": 2540688, "end_pos": 2599539, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001696", "url": "https://www.ensembl.org/id/ENSBTAG00000001696" } ] } } ], "crossref": [ { "id": "E1BB24", "url": "https://alphafold.ebi.ac.uk/entry/E1BB24", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001696", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001696", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12484", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12484", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12492", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12492", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12496", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12496", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19901", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19901", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532175", "url": "https://www.ncbi.nlm.nih.gov/gene/532175", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006535", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006535", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034434", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034434", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034435", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034435", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044462", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044462", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047837", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047837", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532175", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532175", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QSYFMPE", "url": "https://omabrowser.org/oma/group/QSYFMPE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LST9", "url": "https://www.orthodb.org/?gene=A0A3Q1LST9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BB24", "url": "https://www.orthodb.org/?gene=E1BB24", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21245", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21245", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14709", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14709", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179648", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LST9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LST9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LST9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LST9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUB9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUB9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB24", "url": "https://www.uniprot.org/uniprotkb/E1BB24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB24-1", "url": "https://www.uniprot.org/uniprotkb/E1BB24-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEETIDGTNGCSKVRTGTQNEAALLALMEKTGYNMVQENGQRKFGGPPPGWEGPPPPRGCEVFVGKIPRDMYEDELVPVFERAGKIYEFRLMMEFSGENRGYAFVMYTTKEEAQLAIRILNNYEIRPGKFIGVCVSLDNCRLFIGAIPKEKKKEEILDEMKKVTEGVVDVIVYPSATDKTKNRGFAFVEYESHRAAAMARRKLIPGTFQLWGHTIQVDWADPEKEVDEETMQRVKVLYVRNLMISTTEETIKAEFNKFKPGSVERVKKLRDYAFVHFFNREDAVAAMSVMNGKCIDGASIEVTLAKPVNKENTWRQHLNGQISPNSENLIVFANKEESHPKILGKPPALPARLNGQHSPSPPEIERCTYPFFPGTKLTPISMYSLKSNHFNSAVMHLDYYCNKNNWAPPEYYLYSTTSQDGKVLLVYKIIIPAIANGSQSYFMPDKLCTTLEDAKELAAQFTLLHLDYNFRRSSINSLSPVSATLSSGTPSVLPYTSRPYSYSSYSLSPTIPLANGSHVGQRLYISNQASFF", "length": 533, "header": "tr|E1BB24-1|E1BB24_BOVIN Isoform 1 of Probable RNA-binding protein 46 OS=Bos taurus OX=9913 GN=RBM46 PE=4 SV=1 CANONICAL=E1BB24-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LST9-1", "url": "https://www.uniprot.org/uniprotkb/E1BB24/entry#A0A3Q1LST9-1", "sequence": { "sequence": "MSEETIDGTNGCSKVRTGTQNEAALLALMEKTGYNMVQENGQRKFGGPPPGWEGPPPPRGCEVFVGKIPRDMYEDELVPVFERAGKIYEFRLMMEFSGENRGYAFVMYTTKEEAQLAIRILNNYEIRPGKFIGVCVSLDNCRLFIGAIPKEKKKEEILDEMKKVTEGVVDVIVYPSATDKTKNRGFAFVEYESHRAAAMARRKLIPGTFQLWGHTIQVDWADPEKEVDEETMQRVKVLYVRNLMISTTEETIKAEFNKFKPGSVERVKKLRDYAFVHFFNREDAVAAMSVMNGKCIDGASIEVTLAKPVNKENTWRQHLNGQISPNSENLIVFANKEESHPKILGKPPALPARLNGQHSPSPPEIERCTYPFFPGTKLTPISMYSLKSNHFNSAVMHLDYYCNKNNWAPPEYYLYSTTSQDGKVLLVYKIIIPAIANGSQSYFMPDKLCTTLEDAKELAAQFTLLHLDREHSLFSLDLCRRIWRK", "length": 485, "header": "tr|A0A3Q1LST9-1|E1BB24_BOVIN Computationally mapped isoform of Probable RNA-binding protein 46 OS=Bos taurus OX=9913 GN=RBM46 PE=4 SV=1 CANONICAL=E1BB24-1" }, "locus": { "chromosome": "17", "start_pos": 2585674, "end_pos": 2554237, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071328.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071328.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063472.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063472.1" } ] } }, { "isoform_ac": "A0AAA9RUB9-1", "url": "https://www.uniprot.org/uniprotkb/E1BB24/entry#A0AAA9RUB9-1", "sequence": { "sequence": "MSEETIDGTNGCSKVRTGTQNEAALLALMEKTGYNMVQENGQRKFGGPPPGWEGPPPPRGCEVFVGKIPRDMYEDELVPVFERAGKIYEFRLMMEFSGENRGYAFVMYTTKEEAQLAIRILNNYEIRPGKFIGVCVSLDNCRLFIGAIPKEKKKEEILDEMKKVTEGVVDVIVYPSATDKTKNRGFAFVEYESHRAAAMARRKLIPGTFQLWGHTIQVDWADPEKEVDEETMQRVKVLYVRNLMISTTEETIKAEFNKFKPGSVERVKKLRDYAFVHFFNREDAVAAMSVMNGKCIDGASIEVTLAKPVNKENTWRQHLNGQISPNSENLIVFANKEESHPKILGKPPALPARLNGQHSPSPPEIERCTYPFFPGTKLTPISMYSLKSNHFNSAVMHLDYYCNKNNWAPPEYYLYSTTSQDGKVLLVYKIIIPAIANGSQSYFMPDKLCTTLEDAKELAAQFTLLHLGSF", "length": 470, "header": "tr|A0AAA9RUB9-1|E1BB24_BOVIN Computationally mapped isoform of Probable RNA-binding protein 46 OS=Bos taurus OX=9913 GN=RBM46 PE=4 SV=1 CANONICAL=E1BB24-1" }, "locus": { "chromosome": "17", "start_pos": 2585674, "end_pos": 2542666, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122371.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122371.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074660.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074660.1" } ] } }, { "isoform_ac": "E1BB24-1", "url": "https://www.uniprot.org/uniprotkb/E1BB24/entry#E1BB24-1", "sequence": { "sequence": "MSEETIDGTNGCSKVRTGTQNEAALLALMEKTGYNMVQENGQRKFGGPPPGWEGPPPPRGCEVFVGKIPRDMYEDELVPVFERAGKIYEFRLMMEFSGENRGYAFVMYTTKEEAQLAIRILNNYEIRPGKFIGVCVSLDNCRLFIGAIPKEKKKEEILDEMKKVTEGVVDVIVYPSATDKTKNRGFAFVEYESHRAAAMARRKLIPGTFQLWGHTIQVDWADPEKEVDEETMQRVKVLYVRNLMISTTEETIKAEFNKFKPGSVERVKKLRDYAFVHFFNREDAVAAMSVMNGKCIDGASIEVTLAKPVNKENTWRQHLNGQISPNSENLIVFANKEESHPKILGKPPALPARLNGQHSPSPPEIERCTYPFFPGTKLTPISMYSLKSNHFNSAVMHLDYYCNKNNWAPPEYYLYSTTSQDGKVLLVYKIIIPAIANGSQSYFMPDKLCTTLEDAKELAAQFTLLHLDYNFRRSSINSLSPVSATLSSGTPSVLPYTSRPYSYSSYSLSPTIPLANGSHVGQRLYISNQASFF", "length": 533, "header": "tr|E1BB24-1|E1BB24_BOVIN Isoform 1 of Probable RNA-binding protein 46 OS=Bos taurus OX=9913 GN=RBM46 PE=4 SV=1 CANONICAL=E1BB24-1" }, "locus": { "chromosome": "17", "start_pos": 2585674, "end_pos": 2541434, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002223.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002223.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002223.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002223.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:532175", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532175", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6ACM5-1", "protein_name": "Probable RNA-binding protein 46", "gene_name": "Rbm46", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNEENTDGTNGCSKVRTGTQNEAALLALMEKTGYNMVQENGQRKFGGPPPGWEGPPPPRGCEVFVGKIPRDMYEDELVPVFERAGKIYEFRLMMEFSGENRGYAFVMYTTKEEAQLAIRILNNYEIRPGKFIGVCVSLDNCRLFIGAIPKEKKKEEILDEMKKVTEGVVDVIVYPSATDKTKNRGFAFVEYESHRAAAMARRKLIPGTFQLWGHTIQVDWADPEKEVDEETMQRVKVLYVRNLMISTTEETIKAEFNKFKPGAVERVKKLRDYAFVHFFNREDAVAAMSVMNGKCIDGASIEVTLAKPVNKENTWRQHLNGQISPNSENLLVYANKEESHSKSLGKPPTLPTRLNGQHSPSPPEIERCTYPFFPGTKLTPISMYSLKSNHFNSAVMHLDYYCNKNNWAPPEYYLYSTTSQDGKVLLVYKIVIPAIANGSQSYFMPDKLCTTLEDAKELAAQFTLLHLDYNFRRSSINSLSPVSATLSTGTPSVLPYTSRPYSYPSYPLSPTISLANGSHVGQRLYISNQASFF", "length": 533 }, "evidence": [ { "id": "E1BB24", "url": "https://omabrowser.org/oma/group/E1BB24/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0YQQ0-1", "protein_name": "Probable RNA-binding protein 46", "gene_name": "RBM46", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNEENSAATSESDKMRGGNQKAAALLALLDKTGYNMIQENGQRKFGGPPPGWEGPPPPRGCEVFVGKIPRNIYEDELVPLFERAGKIYELRLMMEFSGENRGFAFVMYTTKEDAQLAIKILNNYEIRPGRFIGVCISLDNCRLFIGAIPREKKKEEILKEMKRITEGVVDVIVCPDATDRTKNRGFAFVEYESHRAAAMARRRLLPGTFQLWGRAVQVDWACPEKEVDAETMRRVKVLYVRNLMISTTEDTIKAEFNKFKPRVVERVKKLRDYAFVHFYNREDAVAAMSIMNGKCIDGASIEVTLAKPVNKESTWKQHLNGHVSPCSENLMEFRSREDGHQKSVGKPASLSLSLNGQHSPSSPELEWYPYPFLPGVKLIPISMYSLKSSYFSSAVMRLDYFCYKNNWLPPEYYLYSTTSQDGKIHLVCKVLIPSIADGSQSCFMSHKLCTTLEDARELAARMALLHLDSCTPNSA", "length": 475 }, "evidence": [ { "id": "E1BB24", "url": "https://omabrowser.org/oma/group/E1BB24/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P86049-1", "protein_name": "Probable RNA-binding protein 46", "gene_name": "Rbm46", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNEENTDGTNGCSKVRTGTQNEAALLALMEKTGYNMVQENGQRKFGGPPPGWEGPPPPRGCEVFVGKIPRDMYEDELVPVFERAGKIYEFRLMMEFSGENRGYAFVMYTTKEEAQLAIRILNNYEIRPGKFIGVCVSLDNCRLFIGAIPKEKKKEEILDEMKKVTEGVVDVIVYPSATDKTKNRGFAFVEYESHRAAAMARRKLIPGTFQLWGHTIQVDWADPEKEVDEETMQRVKVLYVRNLMISTTEETIKAEFSKFKPGAVERVKKLRDYAFVHFFHREDAVAAMSVMNGKCIDGASIEVTLAKPVNKENTWRQHLNGQISPNSENLLVYANKEESHSKSLGKPPTLPTRLNGQHSPSPPEIERCTYPFFPGTKLTPISMYSLKSNHFNSAVMHLDYYCNKNNWAPPEYYLYSTTSQDGKVLLVYKIVIPAIANGSQSYFMPDKLCTTLEDAKELAAQFTLLHLDFNFRRSSINSLSPVSTTLSSGTPSMLPYTSRPSSYPSYPLSPTISLANGSHVGQRLYISNQASFF", "length": 533 }, "evidence": [ { "id": "E1BB24", "url": "https://omabrowser.org/oma/group/E1BB24/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TBY0-1", "protein_name": "Probable RNA-binding protein 46", "gene_name": "RBM46", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNEENIDGTNGCSKVRTGIQNEAALLALMEKTGYNMVQENGQRKFGGPPPGWEGPPPPRGCEVFVGKIPRDMYEDELVPVFERAGKIYEFRLMMEFSGENRGYAFVMYTTKEEAQLAIRILNNYEIRPGKFIGVCVSLDNCRLFIGAIPKEKKKEEILDEMKKVTEGVVDVIVYPSATDKTKNRGFAFVEYESHRAAAMARRKLIPGTFQLWGHTIQVDWADPEKEVDEETMQRVKVLYVRNLMISTTEETIKAEFNKFKPGAVERVKKLRDYAFVHFFNREDAVAAMSVMNGKCIDGASIEVTLAKPVNKENTWRQHLNGQISPNSENLIVFANKEESHPKTLGKLPTLPARLNGQHSPSPPEVERCTYPFYPGTKLTPISMYSLKSNHFNSAVMHLDYYCNKNNWAPPEYYLYSTTSQDGKVLLVYKIVIPAIANGSQSYFMPDKLCTTLEDAKELAAQFTLLHLDYNFHRSSINSLSPVSATLSSGTPSVLPYTSRPYSYPGYPLSPTISLANGSHVGQRLCISNQASFF", "length": 533 }, "evidence": [ { "id": "E1BB24", "url": "https://omabrowser.org/oma/group/E1BB24/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BB24", "url": "https://www.uniprot.org/uniprotkb/E1BB24" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "E1BB24", "url": "https://www.uniprot.org/uniprotkb/E1BB24" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BB24", "url": "https://www.uniprot.org/uniprotkb/E1BB24" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BB24", "url": "https://www.uniprot.org/uniprotkb/E1BB24" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "E1BB24", "url": "https://www.uniprot.org/uniprotkb/E1BB24" } ], "pmid": "" }, { "name": "oogenesis", "id": "GO:0048477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048477", "evidence": [ { "database": "UniProtKB", "id": "E1BB24", "url": "https://www.uniprot.org/uniprotkb/E1BB24" } ], "pmid": "" }, { "name": "meiotic cell cycle", "id": "GO:0051321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051321", "evidence": [ { "database": "UniProtKB", "id": "E1BB24", "url": "https://www.uniprot.org/uniprotkb/E1BB24" } ], "pmid": "" }, { "name": "female meiotic nuclear division", "id": "GO:0007143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007143", "evidence": [ { "database": "UniProtKB", "id": "E1BB24", "url": "https://www.uniprot.org/uniprotkb/E1BB24" } ], "pmid": "" }, { "name": "male meiotic nuclear division", "id": "GO:0007140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007140", "evidence": [ { "database": "UniProtKB", "id": "E1BB24", "url": "https://www.uniprot.org/uniprotkb/E1BB24" } ], "pmid": "" }, { "name": "spermatid differentiation", "id": "GO:0048515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048515", "evidence": [ { "database": "UniProtKB", "id": "E1BB24", "url": "https://www.uniprot.org/uniprotkb/E1BB24" } ], "pmid": "" }, { "name": "cell cycle switching, mitotic to meiotic cell cycle", "id": "GO:0051728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051728", "evidence": [ { "database": "UniProtKB", "id": "E1BB24", "url": "https://www.uniprot.org/uniprotkb/E1BB24" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 437, "end_pos": 439, "annotation": "n_glycosylation_sequon" }, { "start_pos": 516, "end_pos": 518, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BB24-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 533, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BB24-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BB24" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BB24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB24" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 61, "end_pos": 139, "start_aa": "Cys", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 437, "end_pos": 439 }, { "start_pos": 516, "end_pos": 518 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BD47-1", "uniprot_ac": "E1BD47", "uniprot_id": "E1BD47_BOVIN", "mass": { "chemical_mass": 84905.0, "monoisotopic_mass": 84905.0 }, "refseq": {}, "gene_names": [ { "name": "ZKSCAN7", "type": "recommended", "evidence": [ { "id": "E1BD47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD47" } ] } ], "protein_names": [ { "name": "Zinc finger with KRAB and SCAN domains 7", "type": "synonym", "evidence": [ { "id": "E1BD47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD47/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "E1BD47", "url": "https://www.uniprot.org/uniprotkb/E1BD47#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0A3Q1LT69", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT69#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BD47", "url": "https://www.uniprot.org/uniprotkb/E1BD47" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZKSCAN7", "url": "https://www.uniprot.org/uniprotkb/E1BD47", "locus": { "chromosome": "22", "start_pos": 16408466, "end_pos": 16387884, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003622", "url": "https://www.ensembl.org/id/ENSBTAG00000003622" } ] } } ], "crossref": [ { "id": "E1BD47", "url": "https://alphafold.ebi.ac.uk/entry/E1BD47", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003622", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003622", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539552", "url": "https://www.ncbi.nlm.nih.gov/gene/539552", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050758", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050758", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539552", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539552", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GHSGQCA", "url": "https://omabrowser.org/oma/group/GHSGQCA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LT69", "url": "https://www.orthodb.org/?gene=A0A3Q1LT69", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BD47", "url": "https://www.orthodb.org/?gene=E1BD47", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23234", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23234:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LT69", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LT69-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT69-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD47", "url": "https://www.uniprot.org/uniprotkb/E1BD47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD47-1", "url": "https://www.uniprot.org/uniprotkb/E1BD47-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATQGRGTSGLFPRGAVLQRQEGCLTVKQEPGSPTWGHGCSLQKNHPPVCEIFRLHFRQLCYHEMSGPQEALSRLRELCRWWLMPEVHTKEQILELLVLEQFLSILPGELRTWVQMHHPESGEEAVAVVEDFQRYVSGPGEVSTPGQEQEIHSEEKTALGATHESPSTSPHSEGSAPGAHLEPPRDPGAHHHLSSEHSAQSASPVPTLPQVGNLRNQVVATVLSMVRPQEAAELEFLSVNYSQKWKGAALSQGALYQNIMLENCHSLAPLDENRMVHSQLPPKQDISEELKSSDRILGVFCGVIPAGQEAGTASKEASENLEVQPSDEEGTRLDSDFLEITQEDKKKSTEDQYDDYKELGGHLDLSSSLSEHQGVLKGQKLYHCDECDKAFNRSSHLIGHQRIHTGEKPYECSECGKTFRQTSQLVVHLRIHTGEKPYECSDCGKTYRHSSHLIQHQRLHYGEKPYKCNECAKAFTQSSQLIDHQRTHSGEKPYECNECGEAFIRNKSLIRHQVLHTGKKPYKCDECGKAFCSNRNLIDHQRIHTGEKPFECNECGKAFSRSKCLIRHQSLHTGEKPYKCSECGKAFNQNSQLADHERIHTGEKPFECNECGKAFGLSKCLIRHQRLHTGEKPYKCKECGKSFNQNSHLIIHQRIHTGEKPYECNECGKVFSYSSSLMVHQRTHTGEKPYKCKDCEKAFSDSSQLIVHQRVHTGEKPYECIECGKAFSQRSTFNHHQRIHTGEKHSGLARSVS", "length": 753, "header": "tr|E1BD47-1|E1BD47_BOVIN Isoform 1 of Zinc finger with KRAB and SCAN domains 7 OS=Bos taurus OX=9913 GN=ZKSCAN7 PE=3 SV=4 CANONICAL=E1BD47-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LT69-1", "url": "https://www.uniprot.org/uniprotkb/E1BD47/entry#A0A3Q1LT69-1", "sequence": { "sequence": "MATQGRGTSGLFPRGAVLQRQEGCLTVKQEPGSPTWGHGCSLQKNHPPVCEIFRLHFRQLCYHEMSGPQEALSRLRELCRWWLMPEVHTKEQILELLVLEQFLSILPGELRTWVQMHHPESGEEAVAVVEDFQRYVSGPGEVSTPGQEQEIHSEEKTALGATHESPSTSPHSEGSAPGAHLEPPRDPGAHHHLSSEHSDENRMVHSQLPPKQDISEELKSSDRILGVFCGVIPAGQEAGTASKEASENLEVQPSDEEGTRLDSDFLEITQEDKKKSTEDQYDDYKELGGHLDLSSSLSEHQGVLKGQKLYHCDECDKAFNRSSHLIGHQRIHTGEKPYECSECGKTFRQTSQLVVHLRIHTGEKPYECSDCGKTYRHSSHLIQHQRLHYGEKPYKCNECAKAFTQSSQLIDHQRTHSGEKPYECNECGEAFIRNKSLIRHQVLHTGKKPYKCDECGKAFCSNRNLIDHQRIHTGEKPFECNECGKAFSRSKCLIRHQSLHTGEKPYKCSECGKAFNQNSQLADHERIHTGEKPFECNECGKAFGLSKCLIRHQRLHTGEKPYKCKECGKSFNQNSHLIIHQRIHTGEKPYECNECGKVFSYSSSLMVHQRTHTGEKPYKCKDCEKAFSDSSQLIVHQRVHTGEKPYECIECGKAFSQRSTFNHHQRIHTGEKHSGLARSVS", "length": 681, "header": "tr|A0A3Q1LT69-1|E1BD47_BOVIN Computationally mapped isoform of Zinc finger with KRAB and SCAN domains 7 OS=Bos taurus OX=9913 GN=ZKSCAN7 PE=3 SV=2 CANONICAL=E1BD47-1" }, "locus": { "chromosome": "22", "start_pos": 16399965, "end_pos": 16389893, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073990.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073990.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058309.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058309.2" } ] } }, { "isoform_ac": "E1BD47-1", "url": "https://www.uniprot.org/uniprotkb/E1BD47/entry#E1BD47-1", "sequence": { "sequence": "MATQGRGTSGLFPRGAVLQRQEGCLTVKQEPGSPTWGHGCSLQKNHPPVCEIFRLHFRQLCYHEMSGPQEALSRLRELCRWWLMPEVHTKEQILELLVLEQFLSILPGELRTWVQMHHPESGEEAVAVVEDFQRYVSGPGEVSTPGQEQEIHSEEKTALGATHESPSTSPHSEGSAPGAHLEPPRDPGAHHHLSSEHSAQSASPVPTLPQVGNLRNQVVATVLSMVRPQEAAELEFLSVNYSQKWKGAALSQGALYQNIMLENCHSLAPLDENRMVHSQLPPKQDISEELKSSDRILGVFCGVIPAGQEAGTASKEASENLEVQPSDEEGTRLDSDFLEITQEDKKKSTEDQYDDYKELGGHLDLSSSLSEHQGVLKGQKLYHCDECDKAFNRSSHLIGHQRIHTGEKPYECSECGKTFRQTSQLVVHLRIHTGEKPYECSDCGKTYRHSSHLIQHQRLHYGEKPYKCNECAKAFTQSSQLIDHQRTHSGEKPYECNECGEAFIRNKSLIRHQVLHTGKKPYKCDECGKAFCSNRNLIDHQRIHTGEKPFECNECGKAFSRSKCLIRHQSLHTGEKPYKCSECGKAFNQNSQLADHERIHTGEKPFECNECGKAFGLSKCLIRHQRLHTGEKPYKCKECGKSFNQNSHLIIHQRIHTGEKPYECNECGKVFSYSSSLMVHQRTHTGEKPYKCKDCEKAFSDSSQLIVHQRVHTGEKPYECIECGKAFSQRSTFNHHQRIHTGEKHSGLARSVS", "length": 753, "header": "tr|E1BD47-1|E1BD47_BOVIN Isoform 1 of Zinc finger with KRAB and SCAN domains 7 OS=Bos taurus OX=9913 GN=ZKSCAN7 PE=3 SV=4 CANONICAL=E1BD47-1" }, "locus": { "chromosome": "22", "start_pos": 16399965, "end_pos": 16389893, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023585.8", "url": "https://www.ensembl.org/id/ENSBTAT00000023585.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023585.7", "url": "https://www.ensembl.org/id/ENSBTAP00000023585.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539552", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539552", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480F126-1", "protein_name": "Zinc finger with KRAB and SCAN domains 7", "gene_name": "ZKSCAN7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAQGRGTLGLIPRGAGLQKQEGHLLVKQEPASQTWGQGCSLQKHHPPVCEIFRLHFRQLCYHEMSGPQEALSRLRELCRWWLMPEVHTKEQILELLVLEQFLSILPGELRTWVQLHHPESGEEAVAVVEDFQRHVSGPGQISAPAQEQEMHSEETTALGATEESPPISPLNEGSASGAHLEPPCDPGAHHLPNRHSAQRASSVPALPQGGNFGDQAATTVLQMVRPQEPAEYEFLSVDYTQKKWKGPALSQRALYRNIVPENCHSLASLAGENGMECSDLPPKQESSKESEASDRTSGVLYEVIPGGPVAGDAYEEALEKLGAQPSDEEGSRLESDLLEITQEDKNKCTEDGCAEYKDLGEHPDLSPSPVGHQGVLKGQKFYQCDECGKAFNRSSHLIGHQRIHTGEKPYECTECGKTFRQTSQLIVHLRIHTGEKPYECSDCGKTYRHSSHLIQHQRLHSGEKPYKCNECAKAFTQSSQLIDHQRTHTGEKPYECSECGEAFIRSKSLVRHQVLHTGEKPYKCNECGKAFCSNRNLIDHQRIHTGEKPYECNECGKAFSRSKCLNRHQSLHTGEKPYKCSECGKAFNQNSQLVDHERIHTGEKPFECNECGKAFSLSKCLIRHQRLHTGEKPYKCKECGKSFNQNSHLIIHQRIHTGEKPYECNECGKVFSYSSSLMVHQRTHTGEKPYKCKDCEKAFSDSSQLIVHQRVHTGEKPYECIECGKAFSQRSTFNHHQRTHTGEKHSGLARSIS", "length": 754 }, "evidence": [ { "id": "E1BD47", "url": "https://omabrowser.org/oma/group/E1BD47/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MCF1-1", "protein_name": "Zinc finger protein with KRAB and SCAN domains 7 isoform X1", "gene_name": "Zkscan7", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTMEGKGTLGLIPRMAVYQKQAGSLTVKQEPGSQTWGQSCSFQKNSPPVCEIFRLHFRQLCYHEMSGPQEALSRLRELCRWWLMPEVHTKEQILELLVLEQFLSILPRELQKWVQLRHPETGEEAVAVVEDFQRHLSGSGEVLPPEQKADMHLKKMESLSATEQSPTSTSSHGSAPEAYVDPPFDLRAHHLPRGHCGPAFPEAENTRAWVTVGNSTAAAVLGMVRPQEIMADNDYMRRKWKSLACRQKALSQNTMEENEHSLASLAAGKNRMESSVCTSKHGFSKGSDSPDTSSGGLFGVALVEPESGAICEGPLAQVEEQPSDEGRERDCHFLEEKDQENSTKDRDEECRDVGEHGNLSSHSVESQREAERQTFYRCDECDKVFNQSSHLYGHQRIHNGERPQECSECGKTFRQTSQLIVHLRAHTAGKPDECSACGKIYLHSSHLKQHQRLHNGERSYKCNEWAKAFPQSSPPIDHKRTHTGEKCYENECGEAFIQSKSLIQHQVLHGGKKTYECNKCGKAFCSGRNLIDHQRIHTGEKPYGCIECGKAFSRSKCLTRHQSLHTGEKPYRCSECGKAFNQNSQLIDHERVHTGEKPFECRQCGKRFSLSKCLIRHQRLHTGEKPYKCSECGKSFNQNSHLIIHQRIHTGEKPYECHECGKVFSYSSSLMVHQRTHTGEKPYKCKDCMKAFSDSSQLTVHQRVHTGEKPYGCIECGKAFSQRSTFNHHQRTHSVEKPSRLLQTPS", "length": 746 }, "evidence": [ { "id": "E1BD47", "url": "https://omabrowser.org/oma/group/E1BD47/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E9PTG0-1", "protein_name": "Zinc finger with KRAB and SCAN domains 7", "gene_name": "Zkscan7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAHGSKFSMTPVCSTYMPWARSYHPRLSLTLATKTSGIQEIPEVTFPCFPSRHCCHFLVSWRCVALVSHRACGWRRGGKCGPHSGRDTGRAGVLARGGASSRSGRLAWGRLGLLAPVRQRCTGQTRPGDTLLTSFLDSEKQFLQLEAETHFQCACCSWDQLLSGITMTMEGRGTLDIIPRTAVYQKQEGSLTVKQEPGSQTWGQKNCPPVCEIFRLHFRQLCYHEMSGPQQALSRLRELCHWWLMPEVHTKEQILELLVLEQFLSILPRELQTWVQLHHPETGEEAVAVVEDFQRHLSESGEVSPPVQEQDVHLKKMVALRATEQSPTLTSGCCSAPDDLLNPPCDPGAHHFPSGHFDPAFPRVGNSRAQAVASVLRMVRPQETAVNKACMQEKWSVLCEAEVVRDEHGPAYLGKNRMGSSEYSPKQGISKGSHSLDTSSGGLFGVALVEPESGDICEDPLAQVEGCPSDEGSELESDFLEKNDEKNSTKDRIEDSKDVRERPESPSSPAEHQREAKRQNSYQCDECGKIFNRSSHLLGHRRIHTGERPSECNECGKTFLQTSQLIVHLRTHTQEKPYECQESGKTYCHSSRLIQHQRLHNGEKPYKGNECVKASIQSSQLIDHKGAHAAEKPNESEEAFIWSKSLQHQVLHTSKKPYECNECGKAFCSNRNLTDHQRIHTGEKPYECIECGKAFSRSKCLTRHQSLHTGEKPYKCSECGKAFSQNSQLIDHERIHTGEKPFECSECGKKFSLSKCLIRHQRLHTGEKPYKCSECGKSFNQNSHLIIHQRIHTGEKPYGCNECGKVFSYSSSLMVHQRTHTGEKPYKCKDCMKSFGDSSQLIVHQRVHTGEKPYECIECGKAFSQRSTFNHHQRTHNVEKPSSLLQTVS", "length": 889 }, "evidence": [ { "id": "E1BD47", "url": "https://omabrowser.org/oma/group/E1BD47/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9PVW1-1", "protein_name": "Zinc finger with KRAB and SCAN domains 7", "gene_name": "Zkscan7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTMEGRGTLDIIPRTAMYQKQEGNLTVKQEPGSQTWGQKNYLPVCEIFRLHFRQLCYHEMSGPQQALSRLRELCHWWLMPEVHTKEQILELLVLEQFLSILPRELQTWVQLHHPETGEEAVAMVEDFQRHLSESGEVSPPVQEQDVHLKKMGALSAAEQSPTSTSNQGLAPGALLDPPCDPGAGHDPAFPKVGNPRAQAVATVLRMARPQETAVNKDYKQEKWSVLCETEVVRDEHGLASLGKNRIGSSEFSPKQDISKGSHSLDTSSEGLFGVALVERASGDICKDPLAQREEHPSDEEGSGLESDFLEKEDKNSTEDRNEECKDVGVHPEMPSSPVEHQGEAKRQKSYQCDECGKVFSQSSRFLGHQRIHVGERPFECNKCGKTFQQISQLVVHLRIHTQEKPYECCESGKTYCHSSHLIQHQRLRNGDKPYKGNECVRASIQSSQLLVHKRTHTGEKPDESGEAFIWNKSLIQHQVLHISKKLYECNECGKAFYTNRNLIDHQRIHTGEKPYECIECGKSFSRSKCLTRHQSLHTGEKTYKCSECGKAFLQNSQLIDHKRVHTGEKPFECSECGKKFSLGKCLIRHQRLHTGEKPYKCSECGKSFNQNSHLIIHQRIHTGEKPYGCNECGKVFSYSSSLMVHQRTHTGEKPYKCKDCMKAFGDSSQLIVHQRVHTGEKPYECAECGKAFSQRSTFNHHQRIHNVAKPSSRLQAVS", "length": 718 }, "evidence": [ { "id": "E1BD47", "url": "https://omabrowser.org/oma/group/E1BD47/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P0L1-1", "protein_name": "Zinc finger protein with KRAB and SCAN domains 7", "gene_name": "ZKSCAN7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTTAGRGNLGLIPRSTAFQKQEGRLTVKQEPANQTWGQGSSLQKNYPPVCEIFRLHFRQLCYHEMSGPQEALSRLRELCRWWLMPEVHTKEQILELLVLEQFLSILPGELRTWVQLHHPESGEEAVAVVEDFQRHLSGSEEVSAPAQKQEMHFEETTALGTTKESPPTSPLSGGSAPGAHLEPPYDPGTHHLPSGDFAQCTSPVPTLPQVGNSGDQAGATVLRMVRPQDTVAYEDLSVDYTQKKWKSLTLSQRALQWNMMPENHHSMASLAGENMMKGSELTPKQEFFKGSESSNRTSGGLFGVVPGAAETGDVCEDTFKELEGQTSDEEGSRLENDFLEITDEDKKKSTKDRYDKYKEVGEHPPLSSSPVEHEGVLKGQKSYRCDECGKAFNRSSHLIGHQRIHTGEKPYECNECGKTFRQTSQLIVHLRTHTGEKPYECSECGKAYRHSSHLIQHQRLHNGEKPYKCNECAKAFTQSSRLTDHQRTHTGEKPYECNECGEAFIRSKSLARHQVLHTGKKPYKCNECGRAFCSNRNLIDHQRIHTGEKPYECSECGKAFSRSKCLIRHQSLHTGEKPYKCSECGKAFNQNSQLIEHERIHTGEKPFECSECGKAFGLSKCLIRHQRLHTGEKPYKCNECGKSFNQNSHLIIHQRIHTGEKPYECNECGKVFSYSSSLMVHQRTHTGEKPYKCNDCGKAFSDSSQLIVHQRVHTGEKPYECSECGKAFSQRSTFNHHQRTHTGEKSSGLAWSVS", "length": 754 }, "evidence": [ { "id": "E1BD47", "url": "https://omabrowser.org/oma/group/E1BD47/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BD47", "url": "https://www.uniprot.org/uniprotkb/E1BD47" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BD47", "url": "https://www.uniprot.org/uniprotkb/E1BD47" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BD47", "url": "https://www.uniprot.org/uniprotkb/E1BD47" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BD47", "url": "https://www.uniprot.org/uniprotkb/E1BD47" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BD47", "url": "https://www.uniprot.org/uniprotkb/E1BD47" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BD47", "url": "https://www.uniprot.org/uniprotkb/E1BD47" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 240, "end_pos": 242, "annotation": "n_glycosylation_sequon" }, { "start_pos": 392, "end_pos": 394, "annotation": "n_glycosylation_sequon" }, { "start_pos": 506, "end_pos": 508, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BD47-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 753, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BD47-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BD47" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BD47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD47" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 382, "end_pos": 409, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BD47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD47" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 54, "end_pos": 134, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 240, "end_pos": 242 }, { "start_pos": 392, "end_pos": 394 }, { "start_pos": 506, "end_pos": 508 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B9F2-1", "uniprot_ac": "E1B9F2", "uniprot_id": "E1B9F2_BOVIN", "mass": { "chemical_mass": 204801.0, "monoisotopic_mass": 204801.0 }, "refseq": { "ac": "XP_005218862", "name": "protein NLRC5 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218862" }, "gene_names": [ { "name": "NLRC5", "type": "recommended", "evidence": [ { "id": "E1B9F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F2" } ] }, { "name": "NLRC5", "type": "synonym", "evidence": [ { "id": "XP_005218862", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218862" } ] } ], "protein_names": [ { "name": "Protein NLRC5", "type": "recommended", "evidence": [ { "id": "E1B9F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F2/entry#names_and_taxonomy" } ] }, { "name": "protein NLRC5 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005218862", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218862" } ] } ], "function": [ { "annotation": "Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTG7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTG7#function" }, { "database": "UniProtKB", "id": "ARBA00058498", "url": "https://www.uniprot.org/uniprotkb/ARBA00058498#function" }, { "database": "UniProtKB", "id": "A0A3Q1MAA2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAA2#function" }, { "database": "UniProtKB", "id": "E1B9F2", "url": "https://www.uniprot.org/uniprotkb/E1B9F2#function" }, { "database": "UniProtKB", "id": "A0A3Q1MCX4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCX4#function" }, { "database": "UniProtKB", "id": "A0ABI0NQZ1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQZ1#function" }, { "database": "UniProtKB", "id": "A0AAA9TVS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVS4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9F2", "url": "https://www.uniprot.org/uniprotkb/E1B9F2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NLRC5", "url": "https://www.uniprot.org/uniprotkb/E1B9F2", "locus": { "chromosome": "18", "start_pos": 25103237, "end_pos": 25042941, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005413", "url": "https://www.ensembl.org/id/ENSBTAG00000005413" } ] } } ], "crossref": [ { "id": "ENSBTAG00000005413", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005413", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "782441", "url": "https://www.ncbi.nlm.nih.gov/gene/782441", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006553", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006553", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007111", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007111", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782441", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782441", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR47189", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47189", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47189:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47189:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05729", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05729", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17776", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17776", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18461", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18461", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27514", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27514", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9758274", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9758274", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005218862", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218862", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTG7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTG7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAA2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAA2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAA2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCX4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCX4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCX4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCX4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVS4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQZ1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NQZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9F2", "url": "https://www.uniprot.org/uniprotkb/E1B9F2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9F2-1", "url": "https://www.uniprot.org/uniprotkb/E1B9F2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPVSLQLGTKNLHGYLVRLLSRNLGWLDAKVKLFLPSVDLGSGYQALDPTQRVILQLQKLHAQGPTTWKSFIQCVCMELDVPMDMEVLLMSTWGHEDGFSSLLEIDEESQSDSQLHPGLKRTHQSCGSSPRPKQFRKQQQELAKRYLQLLRTSAQQRYGNRTPGPGQPLAFHQAYVPPILKWSRASAPFHTQEGATTGNPKAEDGTDVNVRDLFSTKASKGPRVTVLLGKAGMGKTTLAHRLCQKWADGQLDRFQAVFLFEFRQLNLITGSLTLPQLLFDMYLRPEASPEAVFQHLKENAEGILLIFDGLDEILQPCSDKETEDPEDPASALTLFSRLCRGTLLPGCSVMATSRPGKLPACLPTEAATVHMWGFDGPRVEEYVNHFFSDQPSQEAALAELQMDRHLWSMCAVPALCRVACLCLHHLLPGRSRGQSAALLPTMTQNYMQMLLTLNPQGVLRAEPLLGLGEVALSGLESGKVIFSAGDIPASTLDFGAALGLLTSFCVCLGPGHRDTGYAFSHLSLQEFFAALHLLASPQVDREALSQHVTLHSRWVQRTKARLGLSDHLPTFLAGLASRACRSFLSLLAEREEEWVAAKQEVVLQALKKLATRRLTGPKVVELCHRVGETQDPELASFMARSLPQQLPFHNFLLTYADLASLTSILGHRDGPIHLDFEGCPLEPRCPETLAGCGQVENLSFKSRKCGDAFAEALSKSLPTMGSLKKLGLAGSKITAQGISHLVQALPFCPQLEEVSFQDNQLKDREVLNIVEVLSCLPRLQKLDLSRNNVSVSTLLSLTKVAVTCPTIRMLQVRETDLIFLLSPPTETDPELQGDPDLQGNANQRKEAQRRSLALRLQKCQLGVHDVEVLIAQLREGPQLDEVDLSGNQLKDKGCQLMAEAAPQLHITKKLDLSDNELSVAGVLGVLSVVNTYQTLTELHISLLHKTVVFTFAPELEEQEGIQKRATFPDSLMFQMSSEPSLRSPRIRLTHCALQAQRLELLCKALGGSCRLSHLDLSGNALGDEGVALLARLLPGLGSLQSLNLSENHLSLEGVCSLTQCFSTLRWLLHLEFSSASQHVILRGDKRGRDLLAAGSLPEFRAGARLGSGQRHVPRSFCLKECQLEPLSLSYLCKSLEKCPGPLEVQLSCEVLSDQSLETLLYHLPQLPQLSLLQLSQMQLPPESPLLLADLFSLCPQVQKVDLRSLRHLTLHLRSSEEQEDRCCWFTDCGLRQEHVEPLCGLLSKCEDLHQLDLSANLLGDDGLRCLLECLPKVPISGSLDLSHNSMSQESVLCLVEALPSCPRLREASVNLGSKQSFWIHFSRQEETGKTLRLSECHFKPEHMPRLAASLSQALQLTELTLTWCFPGLEQLTVLLGLLTWPTGVLTLRVEEPWVGRVGVLTLLEVCAQASGNITGISISETQKQLCIQLEFPHQENPEAVALRLAHCDLGTQQNLLARKLMETCARLRQLSLSQVNLCDASSLLLQSLLLSLSELKNFRLTSSCVSSKGLALLTSGLSHCHLLEELDLSNNQLGDEGTKVLLGALEGKCRLKRLDLSHLPLGGSTLAVLTQGLGHMTLLQSLRLSKSNIDDVGCCHLSKALRAATSLEELSLSHNQIGNIGAQDLAAVLPGLPELRKIDLSANGIGPAGGARLAESLTLCRHLEELMLGCNALGDCTALGLAKGLPQHLRVLHLPSSHLSPEGVLSLGQALDGCPHVEEISLAENSLAGGVPHFHQGFPVLRKLDLVSCEIDNQTAKPLAASFVLCLALEEITLSWNLLGDEAAAELARVLPQMGRLKRMDLEKNQITAYGAWLLAEGLAQGSGIQVIRLWNNRIPPDMAQHLQNQEPRLDFAFFDNQPQVIPRGT", "length": 1867, "header": "tr|E1B9F2-1|E1B9F2_BOVIN Isoform 1 of Protein NLRC5 OS=Bos taurus OX=9913 GN=NLRC5 PE=3 SV=4 CANONICAL=E1B9F2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTG7-1", "url": "https://www.uniprot.org/uniprotkb/E1B9F2/entry#A0A3Q1LTG7-1", "sequence": { "sequence": "MDPVSLQLGTKNLHGYLVRLLSRNLGWLDAKVKLFLPSVDLGSGYQALDPTQRVILQLQKLHAQGPTTWKSFIQCVCMELDVPMDMEVLLMSTWGHEDGFSSLLEIDEESQSDSQLHPGLKRTHQSCGSSPRPKQFRKQQQELAKRYLQLLRTSAQQRYGNRTPGPGQPLAFHQAYVPPILKWSRASAPFHTQEGATTGNPKAEDGTDVNVRDLFSTKASKGPRVTVLLGKAGMGKTTLAHRLCQKWADGQLDRFQAVFLFEFRQLNLITGSLTLPQLLFDMYLRPEASPEAVFQHLKENAEGILLIFDGLDEILQPCSDKETEDPEDPASALTLFSRLCRGTLLPGCSVMATSRPGKLPACLPTEAATVHMWGFDGPRVEEYVNHFFSDQPSQEAALAELQMDRHLWSMCAVPALCRVACLCLHHLLPGRSRGQSAALLPTMTQNYMQMLLTLNPQGVLRAEPLLGLGEVALSGLESGKVIFSAGDIPASTLDFGAALGLLTSFCVCLGPGHRDTGYAFSHLSLQEFFAALHLLASPQVDREALSQHVTLHSRWVQRTKARLGLSDHLPTFLAGLASRACRSFLSLLAEREEEWVAAKQEVVLQALKKLATRRLTGPKVVELCHRVGETQDPELASFMARSLPQQLPFHNFLLTYADLASLTSILGHRDGPIHLDFEGCPLEPRCPETLAGCGQVENLSFKSRKCGDAFAEALSKSLPTMGSLKKLGLAGSKITAQGISHLVQALPFCPQLEEVSFQDNQLKDREVLNIVEVLSCLPRLQKLDLSRNNVSVSTLLSLTKVAVTCPTIRMLQVRETDLIFLLSPPTETDPELQGDPDLQGNANQRKEAQRRSLALRLQKCQLGVHDVEVLIAQLREGPQLDEVDLSGNQLKDKGCQLMAEAAPQLHITKKLDLSDNELSVAGVLGVLSVVNTYQTLTELHISLLHKTVVFTFAPELEEQEGIQKSLSENHLSLEGVCSLTQCFSTLRWLLHLEFSSASQHVILRGDKRGRDLLAAGSLPEFRAGARLGSGQRHVPRSFCLKECQLEPLSLSYLCKSLEKCPGPLEVQLSCEVLSDQSLETLLYHLPQLPQLSLLQLSQMQLPPESPLLLADLFSLCPQVQKVDLRSLRHLTLHLRSSEEQEDRCCWFTDCGLRQEHVEPLCGLLSKCEDLHQLDLSANLLGDDGLRCLLECLPKVPISGSLDLSHNSMSQESVLCLVEALPSCPRLREASVNLGSKQSFWIHFSRQEETGKTLRLSECHFKPEHMPRLAASLSQALQLTELTLTWCFPGLEQLTVLLGLLTWPTGVLTLRVEEPWVGRVGVLTLLEVCAQASGNITGISISETQKQLCIQLEFPHQENPEAVALRLAHCDLGTQQNLLARKLMETCARLRQLSLSQVNLCDASSLLLQSLLLSLSELKNFRLTSSCVSSKGLALLTSGLSHCHLLEELDLSNNQLGDEGTKVLLGALEGKCRLKRLDLSHLPLGGSTLAVLTQGLGHMTLLQSLRLSKSNIDDVGCCHLSKALRAATSLEELSLSHNQIGNIGAQDLAAVLPGLPELRKIDLSANGIGPAGGARLAESLTLCRHLEELMLGCNALGDCTALGLAKGLPQHLRVLHLPSSHLSPEGVLSLGQALDGCPHVEEISLAENSLAGGVPHFHQGFPVLRKLDLVSCEIDNQTAKPLAASFVLCLALEEITLSWNLLGDEAAAELARVLPQMGRLKRMDLEKNQITAYGAWLLAEGLAQGSGIQVIRLWNNRIPPDMAQHLQNQEPRLDFAFFDNQPQVIPRGT", "length": 1788, "header": "tr|A0A3Q1LTG7-1|E1B9F2_BOVIN Computationally mapped isoform of Protein NLRC5 OS=Bos taurus OX=9913 GN=NLRC5 PE=3 SV=2 CANONICAL=E1B9F2-1" }, "locus": { "chromosome": "18", "start_pos": 25102323, "end_pos": 25044850, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070082.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070082.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060615.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060615.2" } ] } }, { "isoform_ac": "A0A3Q1MAA2-1", "url": "https://www.uniprot.org/uniprotkb/E1B9F2/entry#A0A3Q1MAA2-1", "sequence": { "sequence": "MDPVSLQLGTKNLHGYLVRLLSRNLGWLDAKVKLFLPSVDLGSGYQALDPTQRVILQLQKLHAQGPTTWKSFIQCVCMELDVPMDMEVLLMSTWGHEDGFSSLLEIDEESQSDSQLHPGLKRTHQSCGSSPRPKQFRKQQQELAKRYLQLLRTSAQQRYGNRTPGPGQPLAFHQAYVPPILKWSRASAPFHTQEGATTGNPKAEDGTDVNVRDLFSTKASKGPRVTVLLGKAGMGKTTLAHRLCQKWADGQLDRFQAVFLFEFRQLNLITGSLTLPQLLFDMYLRPEASPEAVFQHLKENAEGILLIFDGLDEILQPCSDKETEDPEDPASALTLFSRLCRGTLLPGCSVMATSRPGKLPACLPTEAATVHMWGFDGPRVEEYVNHFFSDQPSQEAALAELQMDRHLWSMCAVPALCRVACLCLHHLLPGRSRGQSAALLPTMTQNYMQMLLTLNPQGVLRAEPLLGLGEVALSGLESGKVIFSAGDIPASTLDFGAALGLLTSFCVCLGPGHRDTGYAFSHLSLQEFFAALHLLASPQVDREALSQHVTLHSRWVQRTKARLGLSDHLPTFLAGLASRACRSFLSLLAEREEEWVAAKQEVVLQALKKLATRRLTGPKVVELCHRVGETQDPELASFMARSLPQQLPFHNFLLTYADLASLTSILGHRDGPIHLDFEGCPLEPRCPETLAGCGQVENLSFKSRKCGDAFAEALSKSLPTMGSLKKLGLAGSKITAQGISHLVQALPFCPQLEEVSFQDNQLKDREVLNIVEVLSCLPRLQKLDLSRNNVSVSTLLSLTKVAVTCPTIRMLQVRETDLIFLLSPPTETDPELQGDPDLQGNANQRKEAQRRSLALRLQKCQLGVHDVEVLIAQLREGPQLDEVDLSGNQLKDKGCQLMAEAAPQLHITKKLDLSDNELSVAGVLGVLSVVNTYQTLTELHISLLHKTVVFTFAPELEEQEGIQKRATFPDSLMFQMSSEPSLRSPRIRLTHCALQAQRLELLCKALGGSCRLSHLDLSGNALGDEGVALLARLLPGLGSLQSLNLSENHLSLEGVCSLTQCFSTLRWLLHLEFSSASQHVILRGDKRGRDLLAAGSLPEFRAGARLGSGQRHVPRSFCLKECQLEPLSLSYLCKSLEKCPGPLEVQLSCEVLSDQSLETLLYHLPQLPQLSLLQLSQMQLPPESPLLLADLFSLCPQVQKVDLRSLRHLTLHLRSSEEQEDRCCWFTDCGLRQEHVEPLCGLLSKCEDLHQLDLSHNSMSQESVLCLVEALPSCPRLREASVNLGSKQSFWIHFSRQEETGKTLRLSECHFKPEHMPRLAASLSQALQLTELTLTWCFPGLEQLTVLLGLLTWPTGVLTLRVEEPWVGRVGVLTLLEVCAQASGNITGISISETQKQLCIQLEFPHQENPEAVALRLAHCDLGTQQNLLARKLMETCARLRQLSLSQVNLCDASSLLLQSLLLSLSELKNFRLTSSCVSSKGLALLTSGLSHCHLLEELDLSNNQLGDEGTKVLLGALEGKCRLKRLDLSHLPLGGSTLAVLTQGLGHMTLLQSLRLSKSNIDDVGCCHLSKALRAATSLEELSLSHNQIGNIGAQDLAAVLPGLPELRKIDLSANGIGPAGGARLAESLTLCRHLEELMLGCNALGDCTALGLAKGLPQHLRVLHLPSSHLSPEGVLSLGQALDGCPHVEEISLAENSLAGGVPHFHQGFPVLRKLDLVSCEIDNQTAKPLAASFVLCLALEEITLSWNLLGDEAAAELARVLPQMGRLKRMDLEKNQITAYGAWLLAEGLAQGSGIQVIRLWNNRIPPDMAQHLQNQEPRLDFAFFDNQPQVIPRGT", "length": 1839, "header": "tr|A0A3Q1MAA2-1|E1B9F2_BOVIN Computationally mapped isoform of Protein NLRC5 OS=Bos taurus OX=9913 GN=NLRC5 PE=3 SV=2 CANONICAL=E1B9F2-1" }, "locus": { "chromosome": "18", "start_pos": 25102323, "end_pos": 25044850, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068190.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068190.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065458.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065458.2" } ] } }, { "isoform_ac": "A0A3Q1MCX4-1", "url": "https://www.uniprot.org/uniprotkb/E1B9F2/entry#A0A3Q1MCX4-1", "sequence": { "sequence": "MDPVSLQLGTKNLHGYLVRLLSRNLGWLDAKVKLFLPSVDLGSGYQALDPTQRVILQLQKLHAQGPTTWKSFIQCVCMELDVPMDMEVLLMSTWGHEDGFSSLLEIDEESQSDSQLHPGLKRTHQSCGSSPRPKQFRKQQQELAKRYLQLLRTSAQQRYGNRTPGPGQPLAFHQAYVPPILKWSRASAPFHTQEGATTGNPKAEDGTDVNVRDLFSTKASKGPRVTVLLGKAGMGKTTLAHRLCQKWADGQLDRFQAVFLFEFRQLNLITGSLTLPQLLFDMYLRPEASPEAVFQHLKENAEGILLIFDGLDEILQPCSDKETEDPEDPASALTLFSRLCRGTLLPGCSVMATSRPGKLPACLPTEAATVHMWGFDGPRVEEYVNHFFSDQPSQEAALAELQMDRHLWSMCAVPALCRVACLCLHHLLPGRSRGQSAALLPTMTQNYMQMLLTLNPQGVLRAEPLLGLGEVALSGLESGKVIFSAGDIPASTLDFGAALGLLTSFCVCLGPGHRDTGYAFSHLSLQEFFAALHLLASPQVDREALSQHVTLHSRWVQRTKARLGLSDHLPTFLAGLASRACRSFLSLLAEREEEWVAAKQEVVLQALKKLATRRLTGPKVVELCHRVGETQDPELASFMARSLPQQLPFHNFLLTYADLASLTSILGHRDGPIHLDFEGCPLEPRCPETLAGCGQVENLSFKSRKCGDAFAEALSKSLPTMGSLKKLGLAGSKITAQGISHLVQALPFCPQLEEVSFQDNQLKDREVLNIVEVLSCLPRLQKLDLSRNNVSVSTLLSLTKVAVTCPTIRMLQVRETDLIFLLSPPTETDPELQGDPDLQGNANQRKEAQRRSLALRLQKCQLGVHDVEVLIAQLREGPQLDEVDLSDNELSVAGVLGVLSVVNTYQTLTELHISLLHKTVVFTFAPELEEQEGIQKRATFPDSLMFQMSSEPSLRSPRIRLTHCALQAQRLELLCKALGGSCRLSHLDLSGNALGDEGVALLARLLPGLGSLQSLNLSENHLSLEGVCSLTQCFSTLRWLLHLEFSSASQHVILRGDKRGRDLLAAGSLPEFRAGARLGSGQRHVPRSFCLKECQLEPLSLSYLCKSLEKCPGPLEVQLSCEVLSDQSLETLLYHLPQLPQLSLLQLSQMQLPPESPLLLADLFSLCPQVQKVDLRSLRHLTLHLRSSEEQEDRCCWFTDCGLRQEHVEPLCGLLSKCEDLHQLDLSANLLGDDGLRCLLECLPKVPISGSLDLSHNSMSQESVLCLVEALPSCPRLREASVNLGSKQSFWIHFSRQEETGKTLRLSECHFKPEHMPRLAASLSQALQLTELTLTWCFPGLEQLTVLLGLLTWPTGVLTLRVEEPWVGRVGVLTLLEVCAQASGNITGISISETQKQLCIQLEFPHQENPEAVALRLAHCDLGTQQNLLARKLMETCARLRQLSLSQVNLCDASSLLLQSLLLSLSELKNFRLTSSCVSSKGLALLTSGLSHCHLLEELDLSNNQLGDEGTKVLLGALEGKCRLKRLDLSHLPLGGSTLAVLTQGLGHMTLLQSLRLSKSNIDDVGCCHLSKALRAATSLEELSLSHNQIGNIGAQDLAAVLPGLPELRKIDLSANGIGPAGGARLAESLTLCRHLEELMLGCNALGDCTALGLAKGLPQHLRVLHLPSSHLSPEGVLSLGQALDGCPHVEEISLAENSLAGGVPHFHQGFPVLRKLDLVSCEIDNQTAKPLAASFVLCLALEEITLSWNLLGDEAAAELARVLPQMGRLKRMDLEKNQITAYGAWLLAEGLAQGSGIQVIRLWNNRIPPDMAQHLQNQEPRLDFAFFDNQPQVIPRGT", "length": 1839, "header": "tr|A0A3Q1MCX4-1|E1B9F2_BOVIN Computationally mapped isoform of Protein NLRC5 OS=Bos taurus OX=9913 GN=NLRC5 PE=3 SV=2 CANONICAL=E1B9F2-1" }, "locus": { "chromosome": "18", "start_pos": 25102323, "end_pos": 25044850, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069147.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069147.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068228.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068228.2" } ] } }, { "isoform_ac": "A0AAA9TVS4-1", "url": "https://www.uniprot.org/uniprotkb/E1B9F2/entry#A0AAA9TVS4-1", "sequence": { "sequence": "MDPVSLQLGTKNLHGYLVRLLSRNLGWLDAKVKLFLPSVDLGSGYQALDPTQRVILQLQKLHAQGPTTWKSFIQCVCMELDVPMDMEVLLMSTWGHEDGFSSLLEIDEESQSDSQLHPGLKRTHQSCGSSPRPKQFRKQQQELAKRYLQLLRTSAQQRYGNRTPGPGQPLAFHQAYVPPILKWSRASAPFHTQEGATTGNPKAEDGTDVNVRDLFSTKASKGPRVTVLLGKAGMGKTTLAHRLCQKWADGQLDRFQAVFLFEFRQLNLITGSLTLPQLLFDMYLRPEASPEAVFQHLKENAEGILLIFDGLDEILQPCSDKETEDPEDPASALTLFSRLCRGTLLPGCSVMATSRPGKLPACLPTEAATVHMWGFDGPRVEEYVNHFFSDQPSQEAALAELQMDRHLWSMCAVPALCRVACLCLHHLLPGRSRGQSAALLPTMTQNYMQMLLTLNPQGVLRAEPLLGLGEVALSGLESGKVIFSAGDIPASTLDFGAALGLLTSFCVCLGPGHRDTGYAFSHLSLQEFFAALHLLASPQVDREALSQHVTLHSRWVQRTKARLGLSDHLPTFLAGLASRACRSFLSLLAEREEEWVAAKQEVVLQALKKLATRRLTGPKVVELCHRVGETQDPELASFMARSLPQQLPFHNFLLTYADLASLTSILGHRDGPIHLDFEGCPLEPRCPETLAGCGQVENLSFKSRKCGDAFAEALSKSLPTMGSLKKLGLAGSKITAQGISHLVQALPFCPQLEEVSFQDNQLKDREVLNIVEVLSCLPRLQKLDLSRNNVSVSTLLSLTKVAVTCPTIRMLQVRETDLIFLLSPPTETDPELQGDPDLQGNANQRKEAQRRSLALRLQKCQLGVHDVEVLIAQLREGPQLDEVDLSGNQLKDKGCQLMAEAAPQLHITKKLDLSDNELSVAGVLGVLSVVNTYQTLTELHISLLHKTVVFTFAPELEEQEGIQKRATFPDSLMFQMSSEPSLRSPRIRLTHCALQAQRLELLCKALGGSCRLSHLDLSGNALGDEGVALLARLLPGLGSLQSLNLSENHLSLEGVCSLTQCFSTLRWLLHLEFSSASQHVILRGDKRGRDLLAAGSLPEFRAGARLGSGQRHVPRSFCLKECQLEPLSLSYLCKSLEKCPGPLEVQLSCEVLSDQSLETLLYHLPQLPQLSLLQLSQMQLPPESPLLLADLFSLCPQVQKVDLRSLRHLTLHLRSSEEQEDRCCWFTDCGLRQEHVEPLCGLLSKCEDLHQLDLSANLLGDDGLRCLLECLPKVPISGSLDLSHNSMSQESVLCLVEALPSCPRLREASVNLGSKQSFWIHFSRQEETGKTLRLSECHFKPEHMPRLAASLSQALQLTELTVEEPWVGRVGVLTLLEVCAQASGNITGISISETQKQLCIQLEFPHQENPEAVALRLAHCDLGTQQNLLARKLMETCARLRQLSLSQVNLCDASSLLLQSLLLSLSELKNFRLTSSCVSSKGLALLTSGLSHCHLLEELDLSNNQLGDEGTKVLLGALEGKCRLKRLDLSHLPLGGSTLAVLTQGLGHMTLLQSLRLSKSNIDDVGCCHLSKALRAATSLEELSLSHNQIGNIGAQDLAAVLPGLPELRKIDLSANGIGPAGGARLAESLTLCRHLEELMLGCNALGDCTALGLAKGLPQHLRVLHLPSSHLSPEGVLSLGQALDGCPHVEEISLAENSLAGGVPHFHQGFPVLRKLDLVSCEIDNQTAKPLAASFVLCLALEEITLSWNLLGDEAAAELARVLPQMGRLKRMDLEKNQITAYGAWLLAEGLAQGSGIQVIRLWNNRIPPDMAQHLQNQEPRLDFAFFDNQPQVIPRGT", "length": 1839, "header": "tr|A0AAA9TVS4-1|E1B9F2_BOVIN Computationally mapped isoform of Protein NLRC5 OS=Bos taurus OX=9913 GN=NLRC5 PE=3 SV=1 CANONICAL=E1B9F2-1" }, "locus": { "chromosome": "18", "start_pos": 25102323, "end_pos": 25044850, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114295.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114295.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102715.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102715.1" } ] } }, { "isoform_ac": "A0ABI0NQZ1-1", "url": "https://www.uniprot.org/uniprotkb/E1B9F2/entry#A0ABI0NQZ1-1", "sequence": { "sequence": "MDPVSLQLGTKNLHGYLVRLLSRNLGWLDAKVKLFLPSVDLGSGYQALDPTQRVILQLQKLHAQGPTTWKSFIQCVCMELDVPMDMEVLLMSTWGHEDGFSSLLEIDEESQSDSQLHPGLKRTHQSCGSSPRPKQFRKQQQELAKRYLQLLRTSAQQRYGNRTPGPGQPLAFHQAYVPPILKWSRASAPFHTQEGATTGNPKAEDGTDVNVRDLFSTKASKGPRVTVLLGKAGMGKTTLAHRLCQKWADGQLDRFQAVFLFEFRQLNLITGSLTLPQLLFDMYLRPEASPEAVFQHLKENAEGILLIFDGLDEILQPCSDKETEDPEDPASALTLFSRLCRGTLLPGCSVMATSRPGKLPACLPTEAATVHMWGFDGPRVEEYVNHFFSDQPSQEAALAELQMDRHLWSMCAVPALCRVACLCLHHLLPGRSRGQSAALLPTMTQNYMQMLLTLNPQGVLRAEPLLGLGEVALSGLESGKVIFSAGDIPASTLDFGAALGLLTSFCVCLGPGHRDTGYAFSHLSLQEFFAALHLLASPQVDREALSQHVTLHSRWVQRTKARLGLSDHLPTFLAGLASRACRSFLSLLAEREEEWVAAKQEVVLQALKKLATRRLTGPKVVELCHRVGETQDPELASFMARSLPQQLPFHNFLLTYADLASLTSILGHRDGPIHLDFEGCPLEPRCPETLAGCGQVENLSFKSRKCGDAFAEALSKSLPTMGSLKKLGLAGSKITAQGISHLVQALPFCPQLEEVSFQDNQLKDREVLNIVEVLSCLPRLQKLDLSRNNVSVSTLLSLTKVAVTCPTIRMLQVRETDLIFLLSPPTETDPELQGDPDLQGNANQRKEAQRRSLALRLQKCQLGVHDVEVLIAQLREGPQLDEVDLSGNQLKDKGCQLMAEAAPQLHITKKLDLSDNELSVAGVLGVLSVVNTYQTLTELHISLLHKTVVFTFAPELEEQEGIQKRATFPDSLMFQMSSEPSLRSPRIRLTHCALQAQRLELLCKALGGSCRLSHLDLSGNALGDEGVALLARLLPGLGSLQSLNLSENHLSLEGVCSLTQCFSTLRWLLHLEFSSASQHVILRGDKRGRDLLAAGSLPEFRAGARLGSGQRHVPRSFCLKECQLEPLSLSYLCKSLEKCPGPLEVQLSCEVLSDQSLETLLYHLPQLPQLSLLQLSQMQLPPESPLLLADLFSLCPQVQKVDLRSLRHLTLHLRSSEEQEDRCCWFTDCGLRQEHVEPLCGLLSKCEDLHQLDLSANLLGDDGLRCLLECLPKVPISGSLDLSHNSMSQESVLCLVEALPSCPRLREASVNLGSKQSFWIHFSRQEETGKTLRLSECHFKPEHMPRLAASLSQALQLTELTLTWCFPGLEQLTVLLGLLTWPTGVLTLRVEEPWVGRVGVLTLLEVCAQASGNITGISISETQKQLCIQLEFPHQENPEAVALRLAHCDLGTQQNLLARKLMETCARLRQLSLSQVNLCDASSLLLQSLLLSLSELKNFRLTSSCVSSKGLALLTSGLSHCHLLEELDLSNNQLGDEGTKVLLGALEGKCRLKRLDLSHLPLGGSTLAVLTQGLGHMTLLQSLRLSKSNIDDVGCCHLSKALRAATSLEELSLSHNQIGNIGAQDLAAVLPGLPELRKIDLSANGIGPAGGARLAESLTLCRHLEELMLGCNALGDCTALGLAKGLPQHLRVLHLPSSHLSPEGVLSLGQALDGCPHVEEISLAENSLAGGVPHFHQGFPVLRKLDLVSCEIDNQTAKPLAASFVLCLALEEITLSWNLLGDEAAAELARVLPQMGRLKRMDLWNNRIPPDMAQHLQNQEPRLDFAFFDNQPQVIPRGT", 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"length": 1867, "header": "tr|E1B9F2-1|E1B9F2_BOVIN Isoform 1 of Protein NLRC5 OS=Bos taurus OX=9913 GN=NLRC5 PE=3 SV=4 CANONICAL=E1B9F2-1" }, "locus": { "chromosome": "18", "start_pos": 25102323, "end_pos": 25044850, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007129.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007129.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007129.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007129.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:782441", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782441", "resource": "KEGG Pathway" }, { "id": "R-BTA-9758274", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9758274", "resource": "Reactome", "description": "Regulation of NF-kappa B signaling" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular 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"" }, { "name": "positive regulation of type II interferon-mediated signaling pathway", "id": "GO:0060335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060335", "evidence": [ { "database": "UniProtKB", "id": "E1B9F2", "url": "https://www.uniprot.org/uniprotkb/E1B9F2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1044, "end_pos": 1046, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1413, "end_pos": 1415, "annotation": "n_glycosylation_sequon" }, { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1754, "end_pos": 1756, "annotation": "n_glycosylation_sequon" }, { "start_pos": 698, "end_pos": 700, "annotation": "n_glycosylation_sequon" }, { "start_pos": 789, "end_pos": 791, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ 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"https://www.ebi.ac.uk/interpro/entry/pfam/PF00059", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24562", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24562", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LU19", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LU19-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU19-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZ41", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZ41-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC77", "url": "https://www.uniprot.org/uniprotkb/E1BC77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC77-1", "url": 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"MRTRWATPRRAAELLMLLLPGFGLVEPSGHSGNDPFTIVNENTGKCITPLNDWIVVKDCDETKDMLWKWVSQHRLFHLQSQKCLGLDITKPTDSLRMFSCDSNAMLWWKCEHHSLYGAAQYQLALRDGHAIASTNSSDVWKKGGSEENLCAQPYHEIYTRDGNSFGRPCEFPFLVNGTWHHECIFDGDRSGPWCATTLNYEYDQQWGICLQPESGCEDNWEKNEEIGSCYQFNIQATLSWKEAYVSCQNQGADLLSINSAAELTYLKGKEGIARIFWIGLNQLYSARGWEWSDHRPLNFLNWDPDVLMTPIIGRSSCARMDADSGLWQSFSCEAQLPYVCEKLLNSTVELTDMWTYSDTHCDAADWVPNDGFCYLLVNESDSWDKAHTTCQTFSSDLISIHSLADVEVVVTKLHNGDAEGEMWTGLRNINTPALFQWSDGTEVTLTYWDENEPRVPYNETPNCVSYSGKLGQWKVQSCEEKLKYVCKKKGEKLNDTRSDKICPPEEGWKRHGETCYKIYKDEVPFGTNCNLTITSRFEQEYLNDMIKKHTMSPEKYFWTGLRDTDANGEYSWASVGGVKRAVTFSNWNFFEPASPGGCVVMATGKSLGKWEVKDCRSFRALSICKKMSQHSEPEKAAPKPEDPCPEGWHSSPSGLSCYKLFHRERIVRKRNWEEAERFCQALGGHLPSFSHMDEIKEFLHFLIEQFSDQRWLWIGLNKRSPDLQGSWQWSDHTPVSTIITANEFQQDYDIRDCAAVKVMQRPWRRSWYFYDDREYMNLRPFACDAKLEWVCQIPKGHTLKIPDWYNPERAGIHGPPVVVEGSEYWFVADPRLSYEEAVLYCDSNHSSLASLTSFTGLRAIKNKIANISSDEQKWWVRTTEQLKSHRFIYSRDPWHHFPIMFGEECFYLSAKTWFNDLRKPADCSTNLPFVCEKHNVSSLEKYSPDSAAKVQCSGDWITFQNKCFLRINPKSVTFSEASDICHTYGGTLPSVLSQREQDFITSLFPDMEASLWIGLRWTAYEKIKKWMDNRELTYSNFHPLLVGRRLRIPPNIFDEEASYHCAVMLNLQKSPFTGMWNFTSCSEHHTLSLCQKYSEIESRQTLWNTTETMKYQNNLYKIILKTLTWTDALRECQKENMRLVSITDPYQQAFLTVQAVVRNSSLWIGLSSHDDELNFGWSDGKHLQFSRWAENNEQLEDCVVLDTDGFWKTSDCDNNQPGAICYYSGNETKKEVKPVASFQCPSPVLSTPWIPFQNSCYNFLITENRYRVPTQDEVHSKCKTLNPKSHILSIRDEKENNFVLEQLLHYNYMASWVILGITYENNSLRWSDKTTLSYTHWRSGRPAIKDGKFIAGLSTDGFWDIQTFNVVGDLLYFHQHSILACKIEMVDYKEEYNTTLPQFIPYEDGIYNVIQKKVTWYGALNACSQSGGHLASVHDQNGQLFLEDIVKRDGFPLWVGLSSHDGSESSFEWSDGSAFDYIPWKDKKSAGNCVVLDPKGIWKHENCKSVKDGAICYKPTESKEVSSYTYSSRCPGVKGNKSQWVQYRDHCYTSDQALHSFSEARQFCSKLAHSATVVTIKDEDENKFVSRLMRENNNITMRVWLGLSQLSAVTVNKLLPLDHSWNWLDGSKVTFVKWANKIKSGSGQCSILLASNETWTKVECSRGYGRVVCKVPLGPDYRGIGIAFAVLSILAVTCGLIWLFFRRNRWHWLGFSSVRYQQGGNEDEIMLPSFHD", "length": 1732, "header": "tr|E1BC77-1|E1BC77_BOVIN Isoform 1 of Lymphocyte antigen 75 OS=Bos taurus OX=9913 GN=LY75 PE=4 SV=3 CANONICAL=E1BC77-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LU19-1", "url": "https://www.uniprot.org/uniprotkb/E1BC77/entry#A0A3Q1LU19-1", "sequence": { "sequence": "MRTRWATPRRAAELLMLLLPGFGLVEPSGHSGNDPFTIVNENTGKCITPLNDWIVVKDCDETKDMLWKWVSQHRLFHLQSQKCLGLDITKPTDSLRMFSCDSNAMLWWKCEHHSLYGAAQYQLALRDGHAIASTNSSDVWKKGGSEENLCAQPYHEIYTRDGNSFGRPCEFPFLVNGTWHHECIFDGDRSGPWCATTLNYEYDQQWGICLQPESGCEDNWEKNEEIGSCYQFNIQATLSWKEAYVSCQNQGADLLSINSAAELTYLKGKEGIARIFWIGLNQLYSARGWEWSDHRPLNFLNWDPDVLMTPIIGRSSCARMDADSGLWQSFSCEAQLPYVCEKLLNSTVELTDMWTYSDTHCDAADWVPNDGFCYLLVNESDSWDKAHTTCQTFSSDLISIHSLADVEVVVTKLHNGDAEGEMWTGLRNINTPALFQWSDGTEVTLTYWDENEPRVPYNETPNCVSYSGKLGQWKVQSCEEKLKYVCKKKGEKLNDTRSDKICPPEEGWKRHGETCYKIYKDEVPFGTNCNLTITSRFEQEYLNDMIKKHTMSPEKYFWTGLRDTDANGEYSWASVGGVKRAVTFSNWNFFEPASPGGCVVMATGKSLGKWEVKDCRSFRALSICKKMSQHSEPEKAAPKPEDPCPEGWHSSPSGLSCYKLFHRERIVRKRNWEEAERFCQALGGHLPSFSHMDEIKEFLHFLIEQFSDQRWLWIGLNKRSPDLQGSWQWSDHTPVSTIITANEFQQDYDIRDCAAVKVMQRPWRRSWYFYDDREYMNLRPFACDAKLEWVCQIPKGHTLKIPDWYNPERAGIHGPPVVVEGSEYWFVADPRLSYEEAVLYCDSNHSSLASLTSFTGLRAIKNKIANISSDEQKWWVRTTEQLKSHRFIYSRDPWHHFPIMFGEECFYLSAKTWFNDLRKPADCSTNLPFVCEKHNVSSLEKYSPDSAAKVQCSGDWITFQNKCFLRINPKSVTFSEASDICHTYGGTLPSVLSQREQDFITSLFPDMEASLWIGLRWTAYEKIKKWMDNRELTYSNFHPLLVGRRLRIPPNIFDEEASYHCAVMLNLQKSPFTGMWNFTSCSEHHTLSLCQKYSEIESRQTLWNTTETMKYQNNLYKIILKTLTWTDALRECQKENMRLVSITDPYQQAFLTVQAVVRNSSLWIGLSSHDDELNFGWSDGKHLQFSRWAENNEQLEDCVVLDTDGFWKTSDCDNNQPGAICYYSGNPKSHILSIRDEKENNFVLEQLLHYNYMASWVILGITYENNSLRWSDKTTLSYTHWRSGRPAIKDGKFIAGLSTDGFWDIQTFNVVGDLLYFHQHSILACKIEMVDYKEEYNTTLPQFIPYEDGIYNVIQKKVTWYGALNACSQSGGHLASVHDQNGQLFLEDIVKRDGFPLWVGLSSHDGSESSFEWSDGSAFDYIPWKDKKSAGNCVVLDPKGIWKHENCKSVKDGAICYKPTESKEVSSYTYSSRCPGVKGNKSQWVQYRDHCYTSDQALHSFSEARQFCSKLAHSATVVTIKDEDENKFVSRLMRENNNITMRVWLGLSQLSADHSWNWLDGSKVTFVKWANKIKSGSGQCSILLASNETWTKVECSRGYGRVVCKVPLGPDYRGIGIAFAVLSILAVTCGLIWLFFRRNRWHWLGFSSVRYQQGGNEDEIMLPSFHD", "length": 1667, "header": "tr|A0A3Q1LU19-1|E1BC77_BOVIN Computationally mapped isoform of Lymphocyte antigen 75 OS=Bos taurus OX=9913 GN=LY75 PE=4 SV=3 CANONICAL=E1BC77-1" }, "locus": { "chromosome": "2", "start_pos": 36544606, "end_pos": 36454504, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081176.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081176.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060818.3", "url": "https://www.ensembl.org/id/ENSBTAP00000060818.3" } ] } }, { "isoform_ac": "A0A3Q1LZ41-1", "url": "https://www.uniprot.org/uniprotkb/E1BC77/entry#A0A3Q1LZ41-1", "sequence": { "sequence": "MRTRWATPRRAAELLMLLLPGFGLVEPSGHSGNDPFTIVNENTGKCITPLNDWIVVKDCDETKDMLWKWVSQHRLFHLQSQKCLGLDITKPTDSLRMFSCDSNAMLWWKCEHHSLYGAAQYQLALRDGHAIASTNSSDVWKKGGSEENLCAQPYHEIYTRDGNSFGRPCEFPFLVNGTWHHECIFDGDRSGPWCATTLNYEYDQQWGICLQPESGCEDNWEKNEEIGSCYQFNIQATLSWKEAYVSCQNQGADLLSINSAAELTYLKGKEGIARIFWIGLNQLYSARGWEWSDHRPLNFLNWDPDVLMTPIIGRSSCARMDADSGLWQSFSCEAQLPYVCEKLLNSTVELTDMWTYSDTHCDAADWVPNDGFCYLLVNESDSWDKAHTTCQTFSSDLISIHSLADVEVVVTKLHNGDAEGEMWTGLRNINTPALFQWSDGTEVTLTYWDENEPRVPYNETPNCVSYSGKLGQWKVQSCEEKLKYVCKKKGEKLNDTRSDKICPPEEGWKRHGETCYKIYKDEVPFGTNCNLTITSRFEQEYLNDMIKKHTMSPEKYFWTGLRDTDANGEYSWASVGGVKRAVTFSNWNFFEPASPGGCVVMATGKSLGKWEVKDCRSFRALSICKKMSQHSEPEKAAPKPEDPCPEGWHSSPSGLSCYKLFHRERIVRKRNWEEAERFCQALGGHLPSFSHMDEIKEFLHFLIEQFSDQRWLWIGLNKRSPDLQGSWQWSDHTPVSTIITANEFQQDYDIRDCAAVKVMQRPWRRSWYFYDDREYMNLRPFACDAKLEWVCQIPKGHTLKIPDWYNPERAGIHGPPVVVEGSEYWFVADPRLSYEEAVLYCDSNHSSLASLTSFTGLRAIKNKIANISSDEQKWWVRTTEQLKSHRFIYSRDPWHHFPIMFGEECFYLSAKTWFNDLRKPADCSTNLPFVCEKHNVSSLEKYSPDSAAKVQCSGDWITFQNKCFLRINPKSVTFSEASDICHTYGGTLPSVLSQREQDFITSLFPDMEASLWIGLRWTAYEKIKKWMDNRELTYSNFHPLLVGRRLRIPPNIFDEEASYHCAVMLNLQKSPFTGMWNFTSCSEHHTLSLCQKYSEIESRQTLWNTTETMKYQNNLYKIILKTLTWTDALRECQKENMRLVSITDPYQQAFLTVQAVVRNSSLWIGLSSHDDELNFGWSDGKHLQFSRWAENNEQLEDCVVLDTDGFWKTSDCDNNQPGAICYYSGNETKKEVKPVASFQCPSPVLSTPWIPFQNSCYNFLITENRYRVPTQDEVHSKCKTLNPKSHILSIRDEKENNFVLEQLLHYNYMASWVILGITYENNSLRWSDKTTLSYTHWRSGRPAIKDGKFIAGLSTDGFWDIQTFNVVGDLLYFHQHSILACKIEMVDYKEEYNTTLPQFIPYEDGIYNVIQKKVTWYGALNACSQSGGHLASVHDQNGQLFLEDIVKRDGFPLWVGLSSHDGSESSFEWSDGSAFDYIPWKDKKSAGNCVVLDPKGIWKHENCKSVKDGAICYKPTESKEVSSYTYSSRCPGVKGNKSQWVQYRDHCYTSDQALHSFSEARQFCSKLAEAHLKLTYYTELVVEERVLKIYRGTQISTVTYPTSYD", "length": 1605, "header": "tr|A0A3Q1LZ41-1|E1BC77_BOVIN Computationally mapped isoform of Lymphocyte antigen 75 OS=Bos taurus OX=9913 GN=LY75 PE=4 SV=2 CANONICAL=E1BC77-1" }, "locus": { "chromosome": "2", "start_pos": 36540239, "end_pos": 36454504, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079597.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079597.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060948.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060948.2" } ] } }, { "isoform_ac": "E1BC77-1", "url": "https://www.uniprot.org/uniprotkb/E1BC77/entry#E1BC77-1", "sequence": { "sequence": "MRTRWATPRRAAELLMLLLPGFGLVEPSGHSGNDPFTIVNENTGKCITPLNDWIVVKDCDETKDMLWKWVSQHRLFHLQSQKCLGLDITKPTDSLRMFSCDSNAMLWWKCEHHSLYGAAQYQLALRDGHAIASTNSSDVWKKGGSEENLCAQPYHEIYTRDGNSFGRPCEFPFLVNGTWHHECIFDGDRSGPWCATTLNYEYDQQWGICLQPESGCEDNWEKNEEIGSCYQFNIQATLSWKEAYVSCQNQGADLLSINSAAELTYLKGKEGIARIFWIGLNQLYSARGWEWSDHRPLNFLNWDPDVLMTPIIGRSSCARMDADSGLWQSFSCEAQLPYVCEKLLNSTVELTDMWTYSDTHCDAADWVPNDGFCYLLVNESDSWDKAHTTCQTFSSDLISIHSLADVEVVVTKLHNGDAEGEMWTGLRNINTPALFQWSDGTEVTLTYWDENEPRVPYNETPNCVSYSGKLGQWKVQSCEEKLKYVCKKKGEKLNDTRSDKICPPEEGWKRHGETCYKIYKDEVPFGTNCNLTITSRFEQEYLNDMIKKHTMSPEKYFWTGLRDTDANGEYSWASVGGVKRAVTFSNWNFFEPASPGGCVVMATGKSLGKWEVKDCRSFRALSICKKMSQHSEPEKAAPKPEDPCPEGWHSSPSGLSCYKLFHRERIVRKRNWEEAERFCQALGGHLPSFSHMDEIKEFLHFLIEQFSDQRWLWIGLNKRSPDLQGSWQWSDHTPVSTIITANEFQQDYDIRDCAAVKVMQRPWRRSWYFYDDREYMNLRPFACDAKLEWVCQIPKGHTLKIPDWYNPERAGIHGPPVVVEGSEYWFVADPRLSYEEAVLYCDSNHSSLASLTSFTGLRAIKNKIANISSDEQKWWVRTTEQLKSHRFIYSRDPWHHFPIMFGEECFYLSAKTWFNDLRKPADCSTNLPFVCEKHNVSSLEKYSPDSAAKVQCSGDWITFQNKCFLRINPKSVTFSEASDICHTYGGTLPSVLSQREQDFITSLFPDMEASLWIGLRWTAYEKIKKWMDNRELTYSNFHPLLVGRRLRIPPNIFDEEASYHCAVMLNLQKSPFTGMWNFTSCSEHHTLSLCQKYSEIESRQTLWNTTETMKYQNNLYKIILKTLTWTDALRECQKENMRLVSITDPYQQAFLTVQAVVRNSSLWIGLSSHDDELNFGWSDGKHLQFSRWAENNEQLEDCVVLDTDGFWKTSDCDNNQPGAICYYSGNETKKEVKPVASFQCPSPVLSTPWIPFQNSCYNFLITENRYRVPTQDEVHSKCKTLNPKSHILSIRDEKENNFVLEQLLHYNYMASWVILGITYENNSLRWSDKTTLSYTHWRSGRPAIKDGKFIAGLSTDGFWDIQTFNVVGDLLYFHQHSILACKIEMVDYKEEYNTTLPQFIPYEDGIYNVIQKKVTWYGALNACSQSGGHLASVHDQNGQLFLEDIVKRDGFPLWVGLSSHDGSESSFEWSDGSAFDYIPWKDKKSAGNCVVLDPKGIWKHENCKSVKDGAICYKPTESKEVSSYTYSSRCPGVKGNKSQWVQYRDHCYTSDQALHSFSEARQFCSKLAHSATVVTIKDEDENKFVSRLMRENNNITMRVWLGLSQLSAVTVNKLLPLDHSWNWLDGSKVTFVKWANKIKSGSGQCSILLASNETWTKVECSRGYGRVVCKVPLGPDYRGIGIAFAVLSILAVTCGLIWLFFRRNRWHWLGFSSVRYQQGGNEDEIMLPSFHD", "length": 1732, "header": "tr|E1BC77-1|E1BC77_BOVIN Isoform 1 of Lymphocyte antigen 75 OS=Bos taurus OX=9913 GN=LY75 PE=4 SV=3 CANONICAL=E1BC77-1" }, "locus": { "chromosome": "2", "start_pos": 36544606, "end_pos": 36454504, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061220.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061220.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053737.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053737.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "E1BC77", "url": "https://www.uniprot.org/uniprotkb/E1BC77" } ], "pmid": "" }, { "name": "receptor-mediated endocytosis", "id": "GO:0006898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006898", "evidence": [ { "database": "UniProtKB", "id": "E1BC77", "url": "https://www.uniprot.org/uniprotkb/E1BC77" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BC77", "url": "https://www.uniprot.org/uniprotkb/E1BC77" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BC77", "url": "https://www.uniprot.org/uniprotkb/E1BC77" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "E1BC77", "url": "https://www.uniprot.org/uniprotkb/E1BC77" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "E1BC77", "url": "https://www.uniprot.org/uniprotkb/E1BC77" } ], "pmid": "" }, { "name": "transmembrane signaling receptor activity", "id": "GO:0004888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "evidence": [ { "database": "UniProtKB", "id": "E1BC77", "url": "https://www.uniprot.org/uniprotkb/E1BC77" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1077, "end_pos": 1079, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1104, "end_pos": 1106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1159, "end_pos": 1161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1226, "end_pos": 1228, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1321, "end_pos": 1323, "annotation": "n_glycosylation_sequon" }, { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1393, "end_pos": 1395, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1536, "end_pos": 1538, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1594, "end_pos": 1596, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1652, "end_pos": 1654, "annotation": "n_glycosylation_sequon" }, { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 345, "end_pos": 347, "annotation": "n_glycosylation_sequon" }, { "start_pos": 378, "end_pos": 380, "annotation": "n_glycosylation_sequon" }, { "start_pos": 458, "end_pos": 460, "annotation": "n_glycosylation_sequon" }, { "start_pos": 494, "end_pos": 496, "annotation": "n_glycosylation_sequon" }, { "start_pos": 530, "end_pos": 532, "annotation": "n_glycosylation_sequon" }, { "start_pos": 844, "end_pos": 846, "annotation": "n_glycosylation_sequon" }, { "start_pos": 866, "end_pos": 868, "annotation": "n_glycosylation_sequon" }, { "start_pos": 935, "end_pos": 937, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BC77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC77" }, { "id": "PS50041", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50041" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C-type lectin", "eco_id": "ECO_0000259", "start_pos": 227, "end_pos": 341, "start_aa": "Gly", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BC77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC77" }, { "id": "PS51092", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51092" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-II", "eco_id": "ECO_0000259", "start_pos": 164, "end_pos": 211, "start_aa": "Ser", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1077, "end_pos": 1079 }, { "start_pos": 1104, "end_pos": 1106 }, { "start_pos": 1159, "end_pos": 1161 }, { "start_pos": 1226, "end_pos": 1228 }, { "start_pos": 1321, "end_pos": 1323 }, { "start_pos": 135, "end_pos": 137 }, { "start_pos": 1393, "end_pos": 1395 }, { "start_pos": 1536, "end_pos": 1538 }, { "start_pos": 1594, "end_pos": 1596 }, { "start_pos": 1652, "end_pos": 1654 }, { "start_pos": 176, "end_pos": 178 }, { "start_pos": 345, "end_pos": 347 }, { "start_pos": 378, "end_pos": 380 }, { "start_pos": 458, "end_pos": 460 }, { "start_pos": 494, "end_pos": 496 }, { 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"https://www.uniprot.org/uniprotkb/E1B8C9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIASCLCYLLLPAARLFRALSDAFFTCRKNVLLAKSSSSQVEGNFAMAPRGPDQEECEGLLQQWREEGSSQVLSTVSDGPLVDKGLAESSLALLMDNPGEQDAAPEDTWSSRQLSDLRAAENLEEPFPEVLGEEEPLPEVEGPMWAAVPVQTGRQYTDCAVLPMGALATEQWDEDPAVVAWSIAPEPVPQEEAPVWPFEGLGQLQPPVEIPYHEILWREWEDFSTQPDVQGLEAGDGPQFQFTLMSYNILAQDLMQQSSELYLHCHPDILNWSYRFANLMQEFQHWDPDILCLQEVQEDHYWEQLEPSLRMMGFTCFYKRRTGCKTDGCAVCYKPTRFRLLCASPVEYFRPGLELLNRDNVGLVLLLQPLVPEGLGQVSVAPLCVANTHVLYNPRRGDVKLAQMAILLAEVDKVARLSDGSHCPIVLCGDLNSVPDSPLYNFIRDGELQYHGMPAWKVSGQEDFSHQLYQRKLQAPLWPSSLGITDYCQYVTSCHPTSSERRKYSRDFLLRFRFCSMACRRPVGLVLLEGVTDTKPERPAGWAESVIEEDTSESEPDVPRTAGTIQHCLHLTSVYTHFLPQHGRPEVTTMPLGLGTTVDYIFFSAESCENGNRTDRRLYQDGTLKLLGRLSLLSEEILWAANGLPNPFCSSDHLCLLASFGMEIAAP", "length": 667, "header": "tr|E1B8C9-1|E1B8C9_BOVIN Isoform 1 of RNA 2',3'-cyclic phosphatase ANGEL1 OS=Bos taurus OX=9913 GN=ANGEL1 PE=3 SV=3 CANONICAL=E1B8C9-1" }, "isoforms": [ { "isoform_ac": 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"sequence": { "sequence": "MIASCLCYLLLPAARLFRALSDAFFTCRKNVLLAKSSSSQVEGNFAMAPRGPDQEECEGLLQQWREEGSSQVLSTVSDGPLVDKGLAESSLALLMDNPGEQDAAPEDTWSSRQLSDLRAAENLEEPFPEVLGEEEPLPEVEGPMWAAVPVQTGRQYTDCAVLPMGALATEQWDEDPAVVAWSIAPEPVPQEEAPVWPFEGLGQLQPPVEIPYHEILWREWEDFSTQPDVQGLEAGDGPQFQFTLMSYNILAQDLMQQSSELYLHCHPDILNWSYRFANLMQEFQHWDPDILCLQEVQEDHYWEQLEPSLRMMGFTCFYKRRTGCKTDGCAVCYKPTRFRLLCASPVEYFRPGLELLNRDNVGLVLLLQPLVPEGLGQVSVAPLCVANTHVLYNPRRGDVKLAQMAILLAEVDKVARLSDGSHCPIVLCGDLNSVPDSPLYNFIRDGELQYHGMPAWKVSGQEDFSHQLYQRKLQAPLWPSSLGITDYCQYVTSCHPTSSERRKYSRDFLLRFRFCSMACRRPVGLVLLEGVTDTKPERPAGWAESVIEEDTSESEPDVPRTAGTIQHCLHLTSVYTHFLPQHGRPEVTTMPLGLGTTVDYIFFSAESCENGNRTDRRLYQDGTLKLLGRLSLLSEEILWAANGLPNPFCSSDHLCLLASFGMEIAAP", "length": 667, "header": "tr|E1B8C9-1|E1B8C9_BOVIN Isoform 1 of RNA 2',3'-cyclic phosphatase ANGEL1 OS=Bos taurus OX=9913 GN=ANGEL1 PE=3 SV=3 CANONICAL=E1B8C9-1" }, "locus": { "chromosome": "10", "start_pos": 88065276, "end_pos": 88045176, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025915.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025915.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025915.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025915.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "nuclear-transcribed mRNA catabolic process, non-stop decay", "id": "GO:0070481", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070481", "evidence": [ { "database": "UniProtKB", "id": "E1B8C9", "url": "https://www.uniprot.org/uniprotkb/E1B8C9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B8C9", "url": "https://www.uniprot.org/uniprotkb/E1B8C9" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "E1B8C9", "url": "https://www.uniprot.org/uniprotkb/E1B8C9" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "E1B8C9", "url": "https://www.uniprot.org/uniprotkb/E1B8C9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B8C9", "url": "https://www.uniprot.org/uniprotkb/E1B8C9" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "E1B8C9", "url": "https://www.uniprot.org/uniprotkb/E1B8C9" } ], "pmid": "" }, { "name": "cis-Golgi network", "id": "GO:0005801", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005801", "evidence": [ { "database": "UniProtKB", "id": "E1B8C9", "url": "https://www.uniprot.org/uniprotkb/E1B8C9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "E1B8C9", "url": "https://www.uniprot.org/uniprotkb/E1B8C9" } ], "pmid": "" }, { "name": "eukaryotic initiation factor 4E binding", "id": "GO:0008190", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008190", "evidence": [ { "database": "UniProtKB", "id": "E1B8C9", "url": "https://www.uniprot.org/uniprotkb/E1B8C9" } ], "pmid": "" }, { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "E1B8C9", "url": "https://www.uniprot.org/uniprotkb/E1B8C9" } ], "pmid": "" }, { "name": "RNA 2',3'-cyclic phosphatase activity", "id": "GO:0160272", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160272", "evidence": [ { "database": "UniProtKB", "id": "E1B8C9", "url": "https://www.uniprot.org/uniprotkb/E1B8C9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 271, "end_pos": 273, "annotation": "n_glycosylation_sequon" }, { "start_pos": 612, "end_pos": 614, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "85011", "name": "", "equation": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + 2 H2O = a 3'-end ribonucleotide-RNA + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A6H7I3-1" ], "evidence": [ { "id": "85011", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/85011" } ] }, { "id": "85191", "name": "", "equation": "a 3'-end 2'-phospho-ribonucleotide-RNA + H2O = a 3'-end ribonucleotide-RNA + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A6H7I3-1" ], "evidence": [ { "id": "85191", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/85191" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A6H7I3", "gene_name": "ANGEL2", "activity": [ { "ec_number": "3.-.-.-", "activity": "", "evidence": [ { "id": "A6H7I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H7I3" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8C9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 667, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8C9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8C9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8C9", "database": "UniProtKB", "url": 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B7G9-1", "uniprot_ac": "E1B7G9", "uniprot_id": "E1B7G9_BOVIN", "mass": { "chemical_mass": 65289.0, "monoisotopic_mass": 65289.0 }, "refseq": { "ac": "XP_005225429", "name": "APOBEC1 complementation factor isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225429" }, "gene_names": [ { "name": "A1CF", "type": "recommended", "evidence": [ { "id": "E1B7G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G9" } ] }, { "name": "A1CF", "type": "synonym", "evidence": [ { "id": "XP_005225429", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225429" } ] } ], "protein_names": [ { "name": "APOBEC1 complementation factor", "type": "recommended", "evidence": [ { "id": "E1B7G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G9/entry#names_and_taxonomy" } ] }, { "name": "APOBEC1 complementation factor isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005225429", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225429" } ] }, { "name": "APOBEC1-stimulating protein", "type": "synonym", "evidence": [ { "id": "E1B7G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7G9", "url": "https://www.uniprot.org/uniprotkb/E1B7G9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "A1CF", "url": "https://www.uniprot.org/uniprotkb/E1B7G9", "locus": { "chromosome": "26", "start_pos": 8549075, "end_pos": 8455285, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021195", "url": "https://www.ensembl.org/id/ENSBTAG00000021195" } ] } } ], "crossref": [ { "id": "E1B7G9", "url": "https://alphafold.ebi.ac.uk/entry/E1B7G9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021195", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021195", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12486", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12486", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12490", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12490", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12498", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12498", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19900", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19900", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100336715", "url": "https://www.ncbi.nlm.nih.gov/gene/100336715", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006535", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006535", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034538", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034538", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044461", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044461", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100336715", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336715", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YATYEVY", "url": "https://omabrowser.org/oma/group/YATYEVY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7G9", "url": "https://www.orthodb.org/?gene=E1B7G9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21245", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21245", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14709", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14709", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72200", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72200", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-75094", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75094", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005225429", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225429", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUX3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUX3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUX3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P274", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P274", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P274-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P274-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7G9", "url": "https://www.uniprot.org/uniprotkb/E1B7G9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7G9-1", "url": "https://www.uniprot.org/uniprotkb/E1B7G9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDAAPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVTFSNKQEAKNAIKQLNNYEIRNGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYENHRAAAMARRKLLPGRIQLWGHPIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNNIKPGAVERVKKIRDYAFVHFTNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRGAMLQGEYTYSLGHVYDPTTTYLGAPVFYAPQAYTAIPSLHFPTTKGHLGNRAIIRAPSVREIYMNVPVGAAGVRGLGGRGYLAYTGLGRGYQVKGDKREDKLYDLLPGMELTPMNPVTLKPQGIKLAPQILEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKITIPALASQNPAIHPFTPPKLSAYVDEAKTYAAEYTLQALGIPTDGADAQTAAAAAASATAFPGYAVPSPTASVSAAQLKQAVTLGQDLAAYAAYEVYPTFAVTARGDGYGTF", "length": 595, "header": "tr|E1B7G9-1|E1B7G9_BOVIN Isoform 1 of APOBEC1 complementation factor OS=Bos taurus OX=9913 GN=A1CF PE=4 SV=4 CANONICAL=E1B7G9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LUX3-1", "url": "https://www.uniprot.org/uniprotkb/E1B7G9/entry#A0A3Q1LUX3-1", "sequence": { "sequence": "MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDAAPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVTFSNKQEAKNAIKQLNNYEIRNGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYENHRAAAMARRKLLPGRIQLWGHPIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNNIKPGAVERVKKIRDYAFVHFTNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRGAMLQGEYTYSLGHVYDPTTTYLGAPVFYAPQAYTAIPSLHFPTTKGHLGNRAIIRAPSVRGAAGVRGLGGRGYLAYTGLGRGYQVKGDKREDKLYDLLPGMELTPMNPVTLKPQGIKLAPQILEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKITIPALASQNPAIHPFTPPKLSAYVDEAKTYAAEYTLQALGIPTDGADAQTAAAAAASATAFPGYAVPSPTASVSAAQLKQAVTLGQDLAAYAAT", "length": 569, "header": "tr|A0A3Q1LUX3-1|E1B7G9_BOVIN Computationally mapped isoform of APOBEC1 complementation factor OS=Bos taurus OX=9913 GN=A1CF PE=4 SV=2 CANONICAL=E1B7G9-1" }, "locus": { "chromosome": "26", "start_pos": 8549028, "end_pos": 8493243, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074074.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074074.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064360.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064360.2" } ] } }, { "isoform_ac": "A0ABI0P274-1", "url": "https://www.uniprot.org/uniprotkb/E1B7G9/entry#A0ABI0P274-1", "sequence": { "sequence": "MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDAAPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVTFSNKQEAKNAIKQLNNYEIRNGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYENHRAAAMARRKLLPGRIQLWGHPIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNNIKPGAVERVKKIRDYAFVHFTNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRGAMLQGEYTYSLGHVYDPTTTYLGAPVFYAPQAYTAIPSLHFPTTKGHLGNRAIIRAPSVRGAAGVRGLGGRGYLAYTGLGRGYQVKGDKREDKLYDLLPGMELTPMNPVTLKPQGIKLAPQILEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKITIPALASQNPAIHPFTPPKLSAYVDEAKTYAAEYTLQALGIPTDGADAQTAAAAAASATAFPG", "length": 538, "header": "tr|A0ABI0P274-1|A0ABI0P274_BOVIN Computationally mapped isoform of APOBEC1 complementation factor OS=Bos taurus OX=9913 GN=A1CF PE=4 SV=1 CANONICAL=E1B7G9-1" }, "locus": { "chromosome": "26", "start_pos": 8547305, "end_pos": 8493243, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000139625.1", "url": "https://www.ensembl.org/id/ENSBTAT00000139625.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107273.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107273.1" } ] } }, { "isoform_ac": "E1B7G9-1", "url": "https://www.uniprot.org/uniprotkb/E1B7G9/entry#E1B7G9-1", "sequence": { "sequence": "MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDAAPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVTFSNKQEAKNAIKQLNNYEIRNGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYENHRAAAMARRKLLPGRIQLWGHPIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNNIKPGAVERVKKIRDYAFVHFTNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRGAMLQGEYTYSLGHVYDPTTTYLGAPVFYAPQAYTAIPSLHFPTTKGHLGNRAIIRAPSVREIYMNVPVGAAGVRGLGGRGYLAYTGLGRGYQVKGDKREDKLYDLLPGMELTPMNPVTLKPQGIKLAPQILEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKITIPALASQNPAIHPFTPPKLSAYVDEAKTYAAEYTLQALGIPTDGADAQTAAAAAASATAFPGYAVPSPTASVSAAQLKQAVTLGQDLAAYAAYEVYPTFAVTARGDGYGTF", "length": 595, "header": "tr|E1B7G9-1|E1B7G9_BOVIN Isoform 1 of APOBEC1 complementation factor OS=Bos taurus OX=9913 GN=A1CF PE=4 SV=4 CANONICAL=E1B7G9-1" }, "locus": { "chromosome": "26", "start_pos": 8548071, "end_pos": 8493243, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033157.7", "url": "https://www.ensembl.org/id/ENSBTAT00000033157.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033080.6", "url": "https://www.ensembl.org/id/ENSBTAP00000033080.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 553, "start_aa": "Thr", "end_pos": 553, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr553", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100336715", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336715", "resource": "KEGG Pathway" }, { "id": "R-BTA-72200", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72200", "resource": "Reactome", "description": "mRNA Editing: C to U Conversion" }, { "id": "R-BTA-75094", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75094", "resource": "Reactome", "description": "Formation of the Editosome" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A5G9-1", "protein_name": "APOBEC1 complementation factor", "gene_name": "A1CF", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDAAPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVTFSNKQEAKNAIKQLNNYEIRNGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYESHRAAAMARRKLLPGRIQLWGHPIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNNIKPGAVERVKKIRDYAFVHFTNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRGTMLQGEYTYSLGHVYDPTTAYLGAPVFYAPQAYTAIPSLHFPTTKGHLGNRAIIRAPSVREIYMNVPVGAAGVRGLGGRGYLAYTGLGRGYQVKGDKREDKLYDLLPGMELTPMNPVTLKPQGIKLAPQILEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKITIPALASQNPTIHPFTPPKLSAYVDEAKTYAAEYTLQTLGVPTDGADSSTAAAAAASAAAFPGYAVPNPTASVSAAQLKQAVTLGQDLAAYTTYEVYPTFAVTTRGDGYGTF", "length": 595 }, "evidence": [ { "id": "E1B7G9", "url": "https://omabrowser.org/oma/group/E1B7G9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5YD48-1", "protein_name": "APOBEC1 complementation factor", "gene_name": "A1cf", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDSTPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRLMMDFNGNNRGYAFVTFSNKQEAKNAIKQLNNYEIRTGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYESHRAAAMARRRLLPGRIQLWGHPIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNSIKPGAVERVKKIRDYAFVHFSNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRNTMLQGEYTYPLSHVYDPTTTYLGAPVFYTPQAYAAIPSLHFPATKGHLSNRALIRTPSVREIYMNVPVGAAGVRGLGGRGYLAYTGLGRGYHVKGDKREDKLYDLLPGMELTPMNTVSLKPQGIKLAPQILEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKVTIPALASQNPAIHPFIPPKLSAYVDEAKRYAAEHTLQTLGIPTEGGDAGTTAPTATSATVFPGYAVPSATAPVSTAQLKQAVTLGQDLAAYTTYEVYPTFALTTRGDAYGTF", "length": 595 }, "evidence": [ { "id": "E1B7G9", "url": "https://omabrowser.org/oma/group/E1B7G9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q923K9-1", "protein_name": "APOBEC1 complementation factor", "gene_name": "A1cf", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDTTPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVTFSNKQEAKNAIKQLNNYEIRNGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYESHRAAAMARRRLLPGRIQLWGHPIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNSIKPGAVERVKKIRDYAFVHFSNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRNTMLQEYTYPLSHVYDPTTTYLGAPVFYTPQAYAAIPSLHFPATKGHLSNRALIRTPSVREIYMNVPVGAAGVRGLGGRGYLAYTGLGRGYQVKGDKRQDKLYDLLPGMELTPMNTISLKPQGVKLAPQILEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKVTIPALASQNPAIHPFTPPKLSAYVDEAKRYAAEHTLQTLGIPTEGGDAGTTAPTATSATVFPGYAVPSATAPVSTAQLKQAVTLGQDLAAYTTYEVYPTFAVTTRGDGYGTF", "length": 594 }, "evidence": [ { "id": "E1B7G9", "url": "https://omabrowser.org/oma/group/E1B7G9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NQ94-1", "protein_name": "APOBEC1 complementation factor", "gene_name": "A1CF", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDAAPPERGCEIFIGKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVTFSNKVEAKNAIKQLNNYEIRNGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYESHRAAAMARRKLLPGRIQLWGHGIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNNIKPGAVERVKKIRDYAFVHFSNREDAVEAMKALNGKVLDGSPIEVTLAKPVDKDSYVRYTRGTGGRGTMLQGEYTYSLGQVYDPTTTYLGAPVFYAPQTYAAIPSLHFPATKGHLSNRAIIRAPSVREIYMNVPVGAAGVRGLGGRGYLAYTGLGRGYQVKGDKREDKLYDILPGMELTPMNPVTLKPQGIKLAPQILEEICQKNNWGQPVYQLHSAIGQDQRQLFLYKITIPALASQNPAIHPFTPPKLSAFVDEAKTYAAEYTLQTLGIPTDGGDGTMATAAAAATAFPGYAVPNATAPVSAAQLKQAVTLGQDLAAYTTYEVYPTFAVTARGDGYGTF", "length": 594 }, "evidence": [ { "id": "E1B7G9", "url": "https://omabrowser.org/oma/group/E1B7G9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1B7G9", "url": "https://www.uniprot.org/uniprotkb/E1B7G9" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "E1B7G9", "url": "https://www.uniprot.org/uniprotkb/E1B7G9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B7G9", "url": "https://www.uniprot.org/uniprotkb/E1B7G9" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B7G9", "url": "https://www.uniprot.org/uniprotkb/E1B7G9" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": 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"id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020479", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020479", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046327", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046327", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:537889", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537889", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SAQTFDW", "url": "https://omabrowser.org/oma/group/SAQTFDW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LWW4", "url": "https://www.orthodb.org/?gene=A0A3Q1LWW4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B918", "url": "https://www.orthodb.org/?gene=E1B918", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45946", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45946", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45946:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45946:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193040", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWW4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWW4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B918", "url": "https://www.uniprot.org/uniprotkb/E1B918", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B918-1", "url": "https://www.uniprot.org/uniprotkb/E1B918-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDNARMSSFLEYPILSGGDSGTCSARAYPSDHGITTFQSCAVSANSCGSDDRFLVGRGVQISPPHHHHHHHHPQPTTYQTSGNLGVSYSHSSCGPSYSAQNFGAPYSPYALNQEAEVSGGYPSCAPAVYSGNLSSPMVQHHHHHQGYAGGAVGSPQYIHHSYGQEHQSLALATYNNSLSPLHASHQEACRSPASETSSPAQTFDWMKVKRNPPKTGKIGEYGYVGQPNAVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPISPATPTGSEEKAEESSEKSSSSPCVPSPGSSTSDTLPTSH", "length": 333, "header": "tr|E1B918-1|E1B918_BOVIN Isoform 1 of Homeobox A1 OS=Bos taurus OX=9913 GN=HOXA1 PE=3 SV=1 CANONICAL=E1B918-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWW4-1", "url": "https://www.uniprot.org/uniprotkb/E1B918/entry#A0A3Q1LWW4-1", "sequence": { "sequence": 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"MDNARMSSFLEYPILSGGDSGTCSARAYPSDHGITTFQSCAVSANSCGSDDRFLVGRGVQISPPHHHHHHHHPQPTTYQTSGNLGVSYSHSSCGPSYSAQNFGAPYSPYALNQEAEVSGGYPSCAPAVYSGNLSSPMVQHHHHHQGYAGGAVGSPQYIHHSYGQEHQSLALATYNNSLSPLHASHQEACRSPASETSSPAQTFDWMKVKRNPPKTGKIGEYGYVGQPNAVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPISPATPTGSEEKAEESSEKSSSSPCVPSPGSSTSDTLPTSH", "length": 333, "header": "tr|E1B918-1|E1B918_BOVIN Isoform 1 of Homeobox A1 OS=Bos taurus OX=9913 GN=HOXA1 PE=3 SV=1 CANONICAL=E1B918-1" }, "locus": { "chromosome": "4", "start_pos": 68947575, "end_pos": 68946076, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001367.4", "url": "https://www.ensembl.org/id/ENSBTAT00000001367.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001367.2", "url": "https://www.ensembl.org/id/ENSBTAP00000001367.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:537889", "name": "", "url": 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"MDNARMSSFLEYPILGSGDSGTCSARAYTSDHGITTFQSCAVSANSCGGDDRFLVGRGVQISSPHHHHHHHPQPSTYQTSGSLGVSYSHSSCGPSYGAQNFSAPYGPYGLNQEADVSGGYSPCAPAVYSGNLSSPMVQHHHHHHHQGYAGGTVGSPQYIHHSYGQEHQSLALATYNNSLSPLHASHQEACRSPASETPSPAQTFDWMKVKRNPPKTGKVGEYGYVGQPNAVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPISPATPPGSDEKAEESSEKSSSSPCVPSPASSTSDTLPTSH", "length": 334 }, "evidence": [ { "id": "E1B918", "url": "https://omabrowser.org/oma/group/E1B918/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O08656-1", "protein_name": "Homeobox protein Hox-A1", "gene_name": "Hoxa1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDNARLNSFLEYPILGSGDSGTCSARVYSSDHGITTFQSCAVSANSCGGDDRFLGGRGVQITSPHHHHHHHHHPQPATYQTSGNLGVSYSHSSCGPSYGAQNFSAPYGPYGLNQEADVSGGYPPCAPAVYSGNLSSPMVQHHHHHQGYAGGTVGSPQYIHHSYGQEHQSLALATYNNSLSPLHASHQEACRSPASETSSPAQTFDWMKVKRNPPKTGKVGEYGYVGQPNAVRTNFTTKQLTELEKEFHFNKYLTRARSEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPMSPATPPGSDEKTEESSEKSSSSPSAPSPASSTSDTLTTSH", "length": 333 }, "evidence": [ { "id": "E1B918", "url": "https://omabrowser.org/oma/group/E1B918/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q98SI1-1", "protein_name": "Homeobox protein Hox-A1a", "gene_name": "hoxa1a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSTFLDFSSISGGGDGGSGGSCSVRAFHGDHGLSTFQSSCAVRLNSCSGDERFMSNISSQDVINSQPQQAGSYQSPGTLSITYSAHPSYGTQSFCTGYNHYALNQDVESSVSFPQCGPLVYSGNISSTVVQHRHHRHGYSSGNVHLHGQFQYGSATYGNSSDQANLTFVAGCSNPLSPLHVPHHDACCSPLSDGVPTGQTFDWMKVKRNPPKTGKAGEYGFGGQPNTVRTNFSTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPKSLSEQKDGLEKTEDASEKSPSAPSTPSPSPTVEAYSSN", "length": 329 }, "evidence": [ { "id": "E1B918", "url": "https://omabrowser.org/oma/group/E1B918/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "R4GHI8-1", "protein_name": "Homeobox A1", "gene_name": "HOXA1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSSFLEYPVLGGEAGACAARSYHPEHGITTFQPCAVSAGSCSGEDRFLVGRGVSLSPHRHHHPPAQPAAYQHHGGLGVSYAHPGCPPTYGAQGFGAAYGPYALGQDAELGGGFPPCAPAVYSGSLSSAAAQHPHQGYAGGPAQYVPSPYGQEQQSLPLGTYNHALSPLHAGHQDNSRSPSADTSPPAQTFDWMKVKRNPPKTGKAGEYGFVGQPNTVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPISPATPTGCEEKADDPSEKCCPSPCSASPASCASDPGPAAN", "length": 320 }, "evidence": [ { "id": "E1B918", "url": "https://omabrowser.org/oma/group/E1B918/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "E1B918", "url": "https://www.uniprot.org/uniprotkb/E1B918" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "E1B918", "url": "https://www.uniprot.org/uniprotkb/E1B918" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1B918", "url": "https://www.uniprot.org/uniprotkb/E1B918" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1B918", "url": "https://www.uniprot.org/uniprotkb/E1B918" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B918", "url": "https://www.uniprot.org/uniprotkb/E1B918" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1B918", "url": "https://www.uniprot.org/uniprotkb/E1B918" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1B918", "url": "https://www.uniprot.org/uniprotkb/E1B918" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" }, { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" }, { "start_pos": 267, "end_pos": 269, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B918-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 333, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B918-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B918" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B918", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B918" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 225, "end_pos": 285, "start_aa": "Gly", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 132, "end_pos": 134 }, { "start_pos": 175, "end_pos": 177 }, { "start_pos": 233, "end_pos": 235 }, { "start_pos": 267, "end_pos": 269 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDF0-1", "uniprot_ac": "E1BDF0", "uniprot_id": "E1BDF0_BOVIN", "mass": { "chemical_mass": 80877.0, "monoisotopic_mass": 80877.0 }, "refseq": { "ac": "XP_059741091", "name": "nexilin isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741091" }, "gene_names": [ { "name": "NEXN", "type": "recommended", "evidence": [ { "id": "E1BDF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDF0" } ] }, { "name": "NEXN", "type": "synonym", "evidence": [ { "id": "XP_059741091", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741091" } ] } ], "protein_names": [ { "name": "Nexilin", "type": "recommended", "evidence": [ { "id": "E1BDF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDF0/entry#names_and_taxonomy" } ] }, { "name": "F-actin-binding protein", "type": "synonym", "evidence": [ { "id": "E1BDF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDF0/entry#names_and_taxonomy" } ] }, { "name": "nexilin isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059741091", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741091" } ] } ], "function": [ { "annotation": "Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity.", "evidence": [ { "database": "UniProtKB", "id": "E1BDF0", "url": "https://www.uniprot.org/uniprotkb/E1BDF0#function" }, { "database": "UniProtKB", "id": "ARBA00058759", "url": "https://www.uniprot.org/uniprotkb/ARBA00058759#function" }, { "database": "UniProtKB", "id": "A0A3Q1LYQ6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYQ6#function" }, { "database": "UniProtKB", "id": "A0A3Q1M1A2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1A2#function" }, { "database": "UniProtKB", "id": "A0A3Q1N6Z3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N6Z3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDF0", "url": "https://www.uniprot.org/uniprotkb/E1BDF0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NEXN", "url": "https://www.uniprot.org/uniprotkb/E1BDF0", "locus": { "chromosome": "3", "start_pos": 66741752, "end_pos": 66797545, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008921", "url": "https://www.ensembl.org/id/ENSBTAG00000008921" } ] } } ], "crossref": [ { "id": "E1BDF0", "url": "https://alphafold.ebi.ac.uk/entry/E1BDF0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008921", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008921", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504819", "url": "https://www.ncbi.nlm.nih.gov/gene/504819", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BDF0", "url": "https://www.orthodb.org/?gene=E1BDF0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21508", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21508", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21508:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21508:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059741091", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741091", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYQ6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1A2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1A2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1A2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1A2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N6Z3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N6Z3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N6Z3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N6Z3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDF0", "url": "https://www.uniprot.org/uniprotkb/E1BDF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDF0-1", "url": "https://www.uniprot.org/uniprotkb/E1BDF0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNDISQKAEILLSSSKPIPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEEVSSKVEKAYVPKLTGTVKGKFAEMEKQRQEEQRKRTEEERKRRIEQDLLEKRKIQRELARRAEQIEDINNTETESAPEEGDESLLVTVVPVKSHKTSGKIKKNFEDIEKEREEKERVKYEEDKRIRCEEQRRSLKEAKCLSLVMDDELESEAKKESLSSGKLKLTFEELERQRQENRRKQAEEEARKRLEEERRAFEEARRQMVNEEEENQDTENIFKGYRPGKLKLSFEEIERQRREDEKRKAEEDARRRIEEEKKAFAEARRSMVVDDDTPEMYKTISQESLIPGKLEINFEELLKQKMEEERRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFELSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEEDVDIKPAKKSEAPFTHKVNMKARFERMAKAREEEEQRRIEEQKLLRMQFEQKEIDAALQKKREEEEEEEGSTMNGSTIEDEEQTRSGAPWFKKPLRNTSVVDSEPVRFTVKVTGEPKPEITWWFEGEILQDGEDYQYIERGETYCLYLPETFPEDEGEYMCKAVNSKGSAASTCILTIESKN", "length": 675, "header": "tr|E1BDF0-1|E1BDF0_BOVIN Isoform 1 of Nexilin OS=Bos taurus OX=9913 GN=NEXN PE=4 SV=4 CANONICAL=E1BDF0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LYQ6-1", "url": "https://www.uniprot.org/uniprotkb/E1BDF0/entry#A0A3Q1LYQ6-1", "sequence": { "sequence": "MQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEEVSSKVEKAYVPKLTGTVKGKFAEMEKQRQEEQRKRTEEERKRRIEQDLLEKRKIQRELARRAEQEGDESLLVTVVPVKSHKTSGKIKKNFEDIEKEREEKERVKYEEDKRIRCEEQRRSLKEAKCLSLVMDDELESEAKKESLSSGKLKLTFEELERQRQENRRKQAEEEARKRLEEERRAFEEARRQMVNEEEENQDTENIFKGYRPGKLKLSFEEIERQRREDEKRKAEEDARRRIEEEKKAFAEARRSMVVDDDTPEMYKTISQESLIPGKLEINFEELLKQKMEEERRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFELSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEEDVDIKPAKKSEAPFTHKVNMKARFERMAKAREEEEQRRIEEQKLLRMQFEQKEIDAALQKKREEEEEEEGSTMNGSTIEDEEQTRSGAPWFKKPLRNTSVVDSEPVRFTVKVTGEPKPEITWWFEGEILQDGEDYQYIERGETYCLYLPETFPEDEGEYMCKAVNSKGSAASTCILTIESKN", "length": 624, "header": "tr|A0A3Q1LYQ6-1|E1BDF0_BOVIN Computationally mapped isoform of Nexilin OS=Bos taurus OX=9913 GN=NEXN PE=4 SV=2 CANONICAL=E1BDF0-1" }, "locus": { "chromosome": "3", "start_pos": 66773260, "end_pos": 66742855, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068094.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068094.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062735.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062735.2" } ] } }, { "isoform_ac": "A0A3Q1M1A2-1", "url": "https://www.uniprot.org/uniprotkb/E1BDF0/entry#A0A3Q1M1A2-1", "sequence": { "sequence": "MNDISQKAEIKEMLASDDEEEVSSKVEKAYVPKLTGTVKGKFAEMEKQRQEEQRKRTEEERKRRIEQDLLEKRKIQRELARRAEQIEDINNTETESAPEEGDESLLVTVVPVKSHKTSGKIKKNFEDIEKEREEKERVKYEEDKRIRCEEQRRSLKEAKCLSLVMDDELESEAKKESLSSGKLKLTFEELERQRQENRRKQAEEEARKRLEEERRAFEEARRQMVNEEEENQDTENIFKGYRPGKLKLSFEEIERQRREDEKRKAEEDARRRIEEEKKAFAEARRSMVVDDDTPEMYKTISQESLIPGKLEINFEELLKQKMEEERRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFELSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEEDVDIKPAKKSEAPFTHKVNMKARFERMAKAREEEEQRRIEEQKLLRMQFEQKEIDAALQKKREEEEEEEGSTMNGSTIEDEEQTRSGAPWFKKPLRNTSVVDSEPVRFTVKVTGEPKPEITWWFEGEILQDGEDYQYIERGETYCLYLPETFPEDEGEYMCKAVNSKGSAASTCILTIESKN", "length": 611, "header": "tr|A0A3Q1M1A2-1|E1BDF0_BOVIN Computationally mapped isoform of Nexilin OS=Bos taurus OX=9913 GN=NEXN PE=4 SV=2 CANONICAL=E1BDF0-1" }, "locus": { "chromosome": "3", "start_pos": 66774621, "end_pos": 66742855, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067986.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067986.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067070.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067070.2" } ] } }, { "isoform_ac": "A0A3Q1N6Z3-1", "url": "https://www.uniprot.org/uniprotkb/E1BDF0/entry#A0A3Q1N6Z3-1", "sequence": { "sequence": "MNDISQKAEIKEMLASDDEEEVSSKVEKAYVPKLTGTVKGKFAEMEKQRQEEQRKRTEEERKRRIEQDLLEKRKIQRELARRAEQIEDINNTETESAPEEGDESLLVTVVPVKSHKTSGKIKKNFEDIEKEREEKERVKYEEDKRIRCEEQRRSLKEAKCLSLVMDDELESEAKKESLSSGKLKLTFEELERQRQENRRKQAEEEARKRLEEERRAFEEARRQMVNEEEENQDTENIFKGYRPGKLKLSFEEIERQRREDEKRKAEEDARRRIEEEKKAFAEARRSMVVDDDTPEMYKTISQESLIPGKLEINFEELLKQKMEEERRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFELSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEEDVDIKPAKKSEAPFTHKVNMKARFERMAKAREEEEQRRIEEQKLLRMQFEQKEIDAALQKKREEEEEEEGSTMNGSTIEDEEQTRSGAPWFKKPLRNTSVVDSEPVRFTVKVTGEPKPEITWWFEGEILQDGEDYQYIERGETYCLYLPETFPEDEGEYMCKAVNSKGSAASTCILTIETDDY", "length": 612, "header": "tr|A0A3Q1N6Z3-1|E1BDF0_BOVIN Computationally mapped isoform of Nexilin OS=Bos taurus OX=9913 GN=NEXN PE=4 SV=3 CANONICAL=E1BDF0-1" }, "locus": { "chromosome": "3", "start_pos": 66774621, "end_pos": 66742756, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075022.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075022.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066349.3", "url": "https://www.ensembl.org/id/ENSBTAP00000066349.3" } ] } }, { "isoform_ac": "E1BDF0-1", "url": "https://www.uniprot.org/uniprotkb/E1BDF0/entry#E1BDF0-1", "sequence": { "sequence": "MNDISQKAEILLSSSKPIPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEEVSSKVEKAYVPKLTGTVKGKFAEMEKQRQEEQRKRTEEERKRRIEQDLLEKRKIQRELARRAEQIEDINNTETESAPEEGDESLLVTVVPVKSHKTSGKIKKNFEDIEKEREEKERVKYEEDKRIRCEEQRRSLKEAKCLSLVMDDELESEAKKESLSSGKLKLTFEELERQRQENRRKQAEEEARKRLEEERRAFEEARRQMVNEEEENQDTENIFKGYRPGKLKLSFEEIERQRREDEKRKAEEDARRRIEEEKKAFAEARRSMVVDDDTPEMYKTISQESLIPGKLEINFEELLKQKMEEERRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFELSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEEDVDIKPAKKSEAPFTHKVNMKARFERMAKAREEEEQRRIEEQKLLRMQFEQKEIDAALQKKREEEEEEEGSTMNGSTIEDEEQTRSGAPWFKKPLRNTSVVDSEPVRFTVKVTGEPKPEITWWFEGEILQDGEDYQYIERGETYCLYLPETFPEDEGEYMCKAVNSKGSAASTCILTIESKN", "length": 675, "header": "tr|E1BDF0-1|E1BDF0_BOVIN Isoform 1 of Nexilin OS=Bos taurus OX=9913 GN=NEXN PE=4 SV=4 CANONICAL=E1BDF0-1" }, "locus": { "chromosome": "3", "start_pos": 66774621, "end_pos": 66742855, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039125.6", "url": "https://www.ensembl.org/id/ENSBTAT00000039125.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038925.6", "url": "https://www.ensembl.org/id/ENSBTAP00000038925.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "E1BDF0", "url": "https://www.uniprot.org/uniprotkb/E1BDF0" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "E1BDF0", "url": "https://www.uniprot.org/uniprotkb/E1BDF0" } ], "pmid": "" }, { "name": "structural constituent of muscle", "id": "GO:0008307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008307", "evidence": [ { "database": "UniProtKB", "id": "E1BDF0", "url": "https://www.uniprot.org/uniprotkb/E1BDF0" } ], "pmid": "" }, { "name": "cell-cell adhesion mediator activity", "id": "GO:0098632", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098632", "evidence": [ { "database": "UniProtKB", "id": "E1BDF0", "url": "https://www.uniprot.org/uniprotkb/E1BDF0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "E1BDF0", "url": "https://www.uniprot.org/uniprotkb/E1BDF0" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "E1BDF0", "url": "https://www.uniprot.org/uniprotkb/E1BDF0" } ], "pmid": "" }, { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "E1BDF0", "url": "https://www.uniprot.org/uniprotkb/E1BDF0" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BDF0", "url": "https://www.uniprot.org/uniprotkb/E1BDF0" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "E1BDF0", "url": "https://www.uniprot.org/uniprotkb/E1BDF0" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "E1BDF0", "url": "https://www.uniprot.org/uniprotkb/E1BDF0" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "E1BDF0", "url": "https://www.uniprot.org/uniprotkb/E1BDF0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "regulation of cell migration", "id": "GO:0030334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030334", "evidence": [ { "database": "UniProtKB", "id": "E1BDF0", "url": "https://www.uniprot.org/uniprotkb/E1BDF0" } ], "pmid": "" }, { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "E1BDF0", "url": "https://www.uniprot.org/uniprotkb/E1BDF0" } ], "pmid": "" }, { "name": "regulation of cytoskeleton organization", "id": "GO:0051493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051493", "evidence": [ { "database": "UniProtKB", "id": "E1BDF0", "url": "https://www.uniprot.org/uniprotkb/E1BDF0" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "E1BDF0", "url": "https://www.uniprot.org/uniprotkb/E1BDF0" } ], "pmid": "" }, { "name": "dendrite self-avoidance", "id": "GO:0070593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070593", "evidence": [ { "database": "UniProtKB", "id": "E1BDF0", "url": "https://www.uniprot.org/uniprotkb/E1BDF0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 422, "end_pos": 424, "annotation": "n_glycosylation_sequon" }, { "start_pos": 567, "end_pos": 569, "annotation": "n_glycosylation_sequon" }, { "start_pos": 590, "end_pos": 592, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDF0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 675, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDF0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDF0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDF0" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 582, "end_pos": 670, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 154, "end_pos": 156 }, { "start_pos": 422, "end_pos": 424 }, { "start_pos": 567, "end_pos": 569 }, { "start_pos": 590, "end_pos": 592 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BBS1-1", "uniprot_ac": "E1BBS1", "uniprot_id": "E1BBS1_BOVIN", "mass": { "chemical_mass": 62087.0, "monoisotopic_mass": 62087.0 }, "refseq": {}, "gene_names": [ { "name": "PHF1", "type": "recommended", "evidence": [ { "id": "E1BBS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBS1" } ] } ], "protein_names": [ { "name": "PHD finger protein 1", "type": "recommended", "evidence": [ { "id": "E1BBS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBS1/entry#names_and_taxonomy" } ] }, { "name": "Polycomb-like protein 1", "type": "synonym", "evidence": [ { "id": "E1BBS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBS1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBS1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PHF1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1", "locus": { "chromosome": "23", "start_pos": 7591934, "end_pos": 7586525, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001634", "url": "https://www.ensembl.org/id/ENSBTAG00000001634" } ] } } ], "crossref": [ { "id": "E1BBS1", "url": "https://alphafold.ebi.ac.uk/entry/E1BBS1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001634", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001634", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15500", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15500", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15582", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15582", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20449", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20449", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002999", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002999", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040477", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040477", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047399", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047399", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BBS1", "url": "https://www.orthodb.org/?gene=E1BBS1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12628", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12628", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12628:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12628:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14061", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14061", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18104", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18104", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212300", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212300", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LYR7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYR7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYR7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBS1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBS1-1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQPPRLSRSGAPPLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHVPRAPAPGEGEGASWVCRQCVFAIATKRGGALKKGPYARAMLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSETPKGERSSKLLSALNSHKDRFISGREIKKRKCLFGLHARIPPPVEPPPGDGAPTSFPSGQGPGGGVSRPLGKRRRPEPEPLRRRQKGKMEELGPPSAVRNQPEPQEQRERARLQRALQASVSPPPSSPNQSYQGSSGYNFRPTDARCLPSSPIRMFASFHPSASTAGTSGDGEPPDRSPLELHIGFPTDLPKSAPHSMTASSSSVPAPSPGVPRRSAPPSPLCRSLSPGAGGGVRGGVGYLSRGDPVRVLARRVRPDGSVQYLVEWGGGGIF", "length": 567, "header": "tr|E1BBS1-1|E1BBS1_BOVIN Isoform 1 of PHD finger protein 1 OS=Bos taurus OX=9913 GN=PHF1 PE=3 SV=3 CANONICAL=E1BBS1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LYR7-1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1/entry#A0A3Q1LYR7-1", "sequence": { "sequence": "MAQPPRLSRSGAPPLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHVPRAPAPGEGEGASWVCRQCVFAIATKRGGALKKGPYARAMLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSETPKGERSSKLLSALNSHKDRFISGREIKKRKCLFGLHARIPPPVEPPPGDGAPTRAGPWGRGLTSPGEAPEAGARAPEEEAEGENGGAGATLSSAQPARAPGAEGAGSSAKGTAAVPSGCSLPSTPLPAPQGPLGMVNPQTGHPWNFTLVSPQTSLKVPPTR", "length": 457, "header": "tr|A0A3Q1LYR7-1|E1BBS1_BOVIN Computationally mapped isoform of PHD finger protein 1 OS=Bos taurus OX=9913 GN=PHF1 PE=3 SV=1 CANONICAL=E1BBS1-1" }, "locus": { "chromosome": "23", "start_pos": 7591373, "end_pos": 7587475, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084951.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084951.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062750.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062750.2" } ] } }, { "isoform_ac": "E1BBS1-1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1/entry#E1BBS1-1", "sequence": { "sequence": "MAQPPRLSRSGAPPLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHVPRAPAPGEGEGASWVCRQCVFAIATKRGGALKKGPYARAMLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSETPKGERSSKLLSALNSHKDRFISGREIKKRKCLFGLHARIPPPVEPPPGDGAPTSFPSGQGPGGGVSRPLGKRRRPEPEPLRRRQKGKMEELGPPSAVRNQPEPQEQRERARLQRALQASVSPPPSSPNQSYQGSSGYNFRPTDARCLPSSPIRMFASFHPSASTAGTSGDGEPPDRSPLELHIGFPTDLPKSAPHSMTASSSSVPAPSPGVPRRSAPPSPLCRSLSPGAGGGVRGGVGYLSRGDPVRVLARRVRPDGSVQYLVEWGGGGIF", "length": 567, "header": "tr|E1BBS1-1|E1BBS1_BOVIN Isoform 1 of PHD finger protein 1 OS=Bos taurus OX=9913 GN=PHF1 PE=3 SV=3 CANONICAL=E1BBS1-1" }, "locus": { "chromosome": "23", "start_pos": 7591597, "end_pos": 7587475, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002140.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002140.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002140.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002140.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 24, "start_aa": "Thr", "end_pos": 24, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr24", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-212300", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212300", "resource": "Reactome", "description": "PRC2 methylates histones and DNA" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "E1BBS1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1" } ], "pmid": "" }, { "name": "ESC/E(Z) complex", "id": "GO:0035098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035098", "evidence": [ { "database": "UniProtKB", "id": "E1BBS1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BBS1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1" } ], "pmid": "" }, { "name": "site of double-strand break", "id": "GO:0035861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", "evidence": [ { "database": "UniProtKB", "id": "E1BBS1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BBS1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "E1BBS1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1" } ], "pmid": "" }, { "name": "negative regulation of gene expression, epigenetic", "id": "GO:0045814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045814", "evidence": [ { "database": "UniProtKB", "id": "E1BBS1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1" } ], "pmid": "" }, { "name": "DNA repair-dependent chromatin remodeling", "id": "GO:0140861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140861", "evidence": [ { "database": "UniProtKB", "id": "E1BBS1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BBS1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1" } ], "pmid": "" }, { "name": "histone H3K36me3 reader activity", "id": "GO:0140003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140003", "evidence": [ { "database": "UniProtKB", "id": "E1BBS1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BBS1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "E1BBS1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BBS1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1" } ], "pmid": "" }, { "name": "histone methyltransferase binding", "id": "GO:1990226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990226", "evidence": [ { "database": "UniProtKB", "id": "E1BBS1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1" } ], "pmid": "" }, { "name": "transcription corepressor binding", "id": "GO:0001222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001222", "evidence": [ { "database": "UniProtKB", "id": "E1BBS1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1" } ], "pmid": "" }, { "name": "histone H3K4me3 reader activity", "id": "GO:0140002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140002", "evidence": [ { "database": "UniProtKB", "id": "E1BBS1", "url": "https://www.uniprot.org/uniprotkb/E1BBS1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 424, "end_pos": 426, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBS1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 567, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBS1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBS1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBS1" }, { "id": "PS50016", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50016" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PHD-type", "eco_id": "ECO_0000259", "start_pos": 87, "end_pos": 142, "start_aa": "Glu", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 24 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 424, "end_pos": 426 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { 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"database": "Ensembl Gene", "id": "ENSBTAG00000015976", "url": "https://www.ensembl.org/id/ENSBTAG00000015976" } ] } } ], "crossref": [ { "id": "E1B7A1", "url": "https://alphafold.ebi.ac.uk/entry/E1B7A1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015976", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015976", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15533", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15533", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15534", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15534", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22703", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22703", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507057", "url": "https://www.ncbi.nlm.nih.gov/gene/507057", "database": "GeneID", "categories": [ "Genome 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"database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46309", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46309", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46309:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46309:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16737", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16737", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179060", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179060", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZV3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZV3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZV3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZV3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7A1", "url": "https://www.uniprot.org/uniprotkb/E1B7A1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7A1-1", "url": "https://www.uniprot.org/uniprotkb/E1B7A1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKTDEAEKRSRKPEKEPRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCCNPPLSEEMLPPGEWMCHRCTVRRKKREQKKELGHVNGLVDKSGKRTTSPSSDTDLLDRSASKTELKAIAHARILERRASRPGTPTSNASTETPTSEQNDVDEDIIDVDEEPVAAEPDYVQPQLRRPFELLIAAAMERNPTQFQLPNELTCTTALPGSSKRRRKEETTGKNVKKTQHELDHNGLVPLPVKVCFTCNRSCRVAPLIQCDYCPLLFHMDCLEPPLTAMPLGRWMCPNHIEHVVLNQKNMTLSNRCQVFDRFQDTISQHVVKVDFLNRIHKKHPPNRRMLQSVKRRSLKVPDAIKSQYQFPPPLIAPAAIRDGELICNGIPEESQTHLVNSEHLATQAEQQEWLCSVVALQCSILKHLSAKQMPSHWDSEQTEKADIKPVIVTDSSITTSLQTADKAPPPSHYPLSCPSGLSTQNSLSCSPPHQPPTLEDISCSSCAEKSKKAPCGTANGPVNTEVKANGPHLYSSPTDSTDPRRLPGANTPLPGLSHRQGWPRPLTPPAAGGLPNHTVGIIVKTENATGPSSCPQRSVGLVPSLPPSVPSSCASIENTSTLQRKTVQSQIGPPLTDSRPLGSPPNATRVLTPPQAAGDGILATGANQRFCSPAPSSDGKVSPGTLSIGSALTVPSFPANSTAMVDLTNSLRAFMDVNGEIEINMLDEKLIKFLALQRIHQLFPSRVQASPGGVGAHPLASGGHHMEVQRREVQARAVFYPLLGLGGAVNMCYRTLYIGTGADMDVCLTNYGHCNYVSGKHACIFYDENTKHYELLNYSEHGTTVDNVLYSCDFSEKTPPTPPSSIVAKVQSVIRRRRHQKQDEEPSEEAAMMSSQAQGPQRRPCNCKASSSSLIGGSGAGWEGTALLHHGSYIKLGCLQFVFSITEFATKQPKGEAGLLQDGVLAEKLSLKPHQGPVLRSNSVP", "length": 1004, "header": "tr|E1B7A1-1|E1B7A1_BOVIN Isoform 1 of PHD finger protein 12 OS=Bos taurus OX=9913 GN=PHF12 PE=4 SV=1 CANONICAL=E1B7A1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZV3-1", "url": "https://www.uniprot.org/uniprotkb/E1B7A1/entry#A0A3Q1LZV3-1", "sequence": { "sequence": "MSPLPEPSFISNPPLSEEMLPPGEWMCHRCTVRRKKREQKKELGHVNGLVDKSGKRTTSPSSDTDLLDRSASKTELKAIAHARILERRASRPGTPTSNASTETPTSEQNDVDEDIIDVDEEPVAAEPDYVQPQLRRPFELLIAAAMERNPTQFQLPNELTCTTALPGSSKRRRKEETTGKNVKKTQHELDHNGLVPLPVKVCFTCNRSCRVAPLIQCDYCPLLFHMDCLEPPLTAMPLGRWMCPNHIEHVVLNQKNMTLSNRCQVFDRFQDTISQHVVKVDFLNRIHKKHPPNRRMLQSVKRRSLKVPDAIKSQYQFPPPLIAPAAIRDGELICNGIPEESQTHLVNSEHLATQAEQQEWLCSVVALQCSILKHLSAKQMPSHWDSEQTEKADIKPVIVTDSSITTSLQTADKAPPPSHYPLSCPSGLSTQNSLSCSPPHQPPTLEDISCSSCAEKSKKAPCGTANGPVNTEVKANGPHLYSSPTDSTDPRRLPGANTPLPGLSHRQGWPRPLTPPAAGGLPNHTVGIIVKTENATGPSSCPQRSVGLVPSLPPSVPSSCASIENTSTLQRKTVQSQIGPPLTDSRPLGSPPNATRVLTPPQAAGDGILATGANQRFCSPAPSSDGKVSPGTLSIGSALTVPSFPANSTAMVDLTNSLRAFMDVNGEIEINMLDEKLIKFLALQRIHQLFPSRVQASPGGVGAHPLASGGHHMEVQRREVQARAVFYPLLGLGGAVNMCYRTLYIGTGADMDVCLTNYGHCNYVSGKHACIFYDENTKHYELLNYSEHGTTVDNVLYSCDFSEKTPPTPPSSIVAKVQSVIRRRRHQKQDEEPSEEAAMMSSQAQGPQRRPCNCKASSSSLIGGSGAGWEGTALLHHGSYIKLGCLQFVFSITEFATKQPKGEAGLLQDGVLAEKLSLKPHQGPVLRSNSVP", "length": 932, "header": "tr|A0A3Q1LZV3-1|E1B7A1_BOVIN Computationally mapped isoform of PHD finger protein 12 OS=Bos taurus OX=9913 GN=PHF12 PE=4 SV=1 CANONICAL=E1B7A1-1" }, "locus": { "chromosome": "19", "start_pos": 20303019, "end_pos": 20278139, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075687.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075687.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063195.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063195.1" } ] } }, { "isoform_ac": "E1B7A1-1", "url": "https://www.uniprot.org/uniprotkb/E1B7A1/entry#E1B7A1-1", "sequence": { "sequence": "MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKTDEAEKRSRKPEKEPRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCCNPPLSEEMLPPGEWMCHRCTVRRKKREQKKELGHVNGLVDKSGKRTTSPSSDTDLLDRSASKTELKAIAHARILERRASRPGTPTSNASTETPTSEQNDVDEDIIDVDEEPVAAEPDYVQPQLRRPFELLIAAAMERNPTQFQLPNELTCTTALPGSSKRRRKEETTGKNVKKTQHELDHNGLVPLPVKVCFTCNRSCRVAPLIQCDYCPLLFHMDCLEPPLTAMPLGRWMCPNHIEHVVLNQKNMTLSNRCQVFDRFQDTISQHVVKVDFLNRIHKKHPPNRRMLQSVKRRSLKVPDAIKSQYQFPPPLIAPAAIRDGELICNGIPEESQTHLVNSEHLATQAEQQEWLCSVVALQCSILKHLSAKQMPSHWDSEQTEKADIKPVIVTDSSITTSLQTADKAPPPSHYPLSCPSGLSTQNSLSCSPPHQPPTLEDISCSSCAEKSKKAPCGTANGPVNTEVKANGPHLYSSPTDSTDPRRLPGANTPLPGLSHRQGWPRPLTPPAAGGLPNHTVGIIVKTENATGPSSCPQRSVGLVPSLPPSVPSSCASIENTSTLQRKTVQSQIGPPLTDSRPLGSPPNATRVLTPPQAAGDGILATGANQRFCSPAPSSDGKVSPGTLSIGSALTVPSFPANSTAMVDLTNSLRAFMDVNGEIEINMLDEKLIKFLALQRIHQLFPSRVQASPGGVGAHPLASGGHHMEVQRREVQARAVFYPLLGLGGAVNMCYRTLYIGTGADMDVCLTNYGHCNYVSGKHACIFYDENTKHYELLNYSEHGTTVDNVLYSCDFSEKTPPTPPSSIVAKVQSVIRRRRHQKQDEEPSEEAAMMSSQAQGPQRRPCNCKASSSSLIGGSGAGWEGTALLHHGSYIKLGCLQFVFSITEFATKQPKGEAGLLQDGVLAEKLSLKPHQGPVLRSNSVP", "length": 1004, "header": "tr|E1B7A1-1|E1B7A1_BOVIN Isoform 1 of PHD finger protein 12 OS=Bos taurus OX=9913 GN=PHF12 PE=4 SV=1 CANONICAL=E1B7A1-1" }, "locus": { "chromosome": "19", "start_pos": 20316575, "end_pos": 20278139, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021255.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021255.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021255.5", "url": "https://www.ensembl.org/id/ENSBTAP00000021255.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 880, "start_aa": "Thr", "end_pos": 880, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr880", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:507057", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507057", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PLW9-1", "protein_name": "PHD finger protein 12", "gene_name": "PHF12", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKSEDGEKRSRRPEKEPRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCCNPPLSEEMLPPGEWMCHRCTVRRKKREQKKELGQVNGLVDKTGKRTTSPTSDADLLDRSSSSIRANAHARILERRASRPGTPTSNASTETPNSEQNDVDEDIIDVDDDSAIAEMDCGQPQLKRPFELLIAAAMERNPTQFQLPNELTCTTALPGTSKRRRKEETTGKNVKKAQHELDHNGLVPLPVKVCFTCNRSCRVAPLIQCDYCPLLFHMDCLEPPLTAMPLGRWMCPNHIEHVVLNQKNLTLSNRCRVFDRFQDTISQHVVKVDFLNRIHKKHPPNRRVLQSVKRKGLKVPDAIKSQYRLPPPLLAPAAIRDGELICNGIPEEPLQKHLLNTEHLASQTEQQEWLCSVVALQCSILKHLSAKQMTSLWDSEQTEKADIKPVIVADGTLANPYQAADKAPTPSLYSMSSCTSGITTQNSLSSSQSQQTLSQEDVNCSSCLDKSKKVSSCGTSNGPTASDVKVNGPHFYGVSSEPSAQLTDSQRLIGAGNTIPVLSHRQTWPRPLTPPATCGLLNHTIGTIVKTENVGGPVSCAQRGSVPVTSMPTSISSSCASLETTSTLQRKNVQTQIGPPLSADLRSMGSPLTATRALTPPQAAGDGISAVGSANRFCSPAPPSDGKVSPSTLSIGSALTLPSSLTSNSAAMLDLTSSLKAFMDGEIEINMLDEQLIKFLALQRIHQLFPSKAQSLASSVSAHQQSPVANHIEAQRKEVQARAVFYPLMGLGGAVNMCYRTLYIGTGADMDVCLTSYGHCNYVSGKHACIFYDENTKHYELLNYSEHGTTVDNVLYSCDFSEKMAPTPPSSIVAKVQSVIKRHKSRKQEEEPHGEAAVMNSQAQGQHRKPCNCKASSSSLIGGSGAGWEGTALLHHGSYIKLGCLQFVFSITEFATKQPKGDTALVQDMDLEEKLSLKPHQVPVLRSNSVP", "length": 1009 }, "evidence": [ { "id": "E1B7A1", "url": "https://omabrowser.org/oma/group/E1B7A1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RNA4-1", "protein_name": "PHD finger protein 12", "gene_name": "PHF12", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKADEAEKRSRKPEKEPRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCCNPPLSEEMLPPGEWMCHRCTVRRKKREQKKELGHVNGLVDKSGKRTTSPSSDTDLLDRSASKTELKAIAHARILERRASRPGTPTSNASTETPTSEQNDVDEDIIDVDEEPVAAEPDCVQPQLRRPFELLIAAAMERNPTQFQLPNELTCTTALPGSSKRRRKEETTGKNVKKTQHELDHNGLVPLPVKVCFTCNRSCRVAPLIQCDYCPLLFHMDCLEPPLTAMPLGRWMCPNHIEHVVLNQKNMTLSNRCQVFDRFQDTISQHVVKVDFLNRIHKKHPPNRRVLQSVKRRSLKVPDAIKSQYQFPPPLIAPAAIRDGELICNGIPEESQTHLLNSEHLATQAEQQEWLCSVVALQCSILKHLSAKQMPSHWDSEQTEKADIKPVIVTDSSITNSLQTADKAPTPSHYPLSCPSGLSTQNSLSCSPPHQPPTLEDISCSSCAEKSKKAPCGTANGPVNTEVKANGPHLYSSPTDSTDPRRLPGANTPLPGLSHRQGWPRPLTPPAAGGLQNHTVGIIVKTENATGPSSCPQRSLVPVPSLPPSIPSSCASIENTSTLQRKTVQSQIGPPLTDSRPLGSPPNATRVLTPPQAGDGILATGANQRFCSPAPSSDGKVSPGTLSIGSALTVPSFPANSTAMVDLTNSLRAFMDVNGEIEINMLDEKLIKFLALQRIHQLFPSRVQASPGSVGAHPLASGGHHTEVQRREVQARAVFYPLLGLGGAVNMCYRTLYIGTGADMDVCLTNYGHCNYVSGKHACIFYDENTKHYELLNYSEHGTTVDNVLYSCDFSEKTPPTPPSSIVAKVQSVIRRRRHQKQDEEPSEEAAMMSSQAQGPQRRPCNCKASSSSLIGGSGAGWEGTALLHHGSYIKLGCLQFVFSITEFATKQPKGDASLLQDGVLAEKLSLKPHQGPVLRSNSVP", "length": 1003 }, "evidence": [ { "id": "E1B7A1", "url": "https://omabrowser.org/oma/group/E1B7A1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5SPL2-1", "protein_name": "PHD finger protein 12", "gene_name": "Phf12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKTDEAEKRSRKPEKESRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCCNPPLSEEMLPPGEWMCHRCTVRRKKREQKKELGHVNGLVDKSSKRTTSPSSDTDLLDRPASKTELKAIAHARILERRASRPGTPTSNASTETPTSEHNDVDEDIVDVDEEPVAAEPDYVQPQLRRPFELLIAAAMERNPTQFQLPNELTCTTALPGSSKRRRKEETTGKNVKRTQHELDHNGLVPLPVKVCFTCNRSCRVAPLIQCDYCPLLFHMDCLEPPLTAMPLGRWMCPNHIEHVVLNQKNLTLSNRCQVFDRFQDTISQHVVKVDFLNRIHKKHPPNRRVLQSVKRRSLKVPDAIKSQYQFPPPLIAPAAIRDGELICSGVPEESQTHLLNSEHLATQAEQQEWLCSVVALQCSILKHLSAKQMPSPWDSEQTEKADIKPVIVTDSSITTSLQTADKAPLPSHYPLSCPSAVSTQNSLGCSPPHQPPTLEDISCSSCVEKSKKAPCGTANGPVNTEIKANGPHLYSSPTDSTDPRRLPGANTPLPGLTHRQGWPRPLTPPSAGGLQNHVGIIVKTENATGPSSCPQRSLVPVPSLPPSIPSSCASIENTSTLHRKTVQSQIGPSSTESRPLGSPPNATRVLTPPQAAGDSILATGANQRFCSPAPSSDGKVSPGTLSIGSALTVPSFPANSTAMVDLTNSLRAFMDVNGEIEINMLDEKLIKFLALQRVHQLFPSRVQASPGNVGTHPLASGGHHPEVQRKEVQARAVFCPLLGLGGAVNMCYRTLYIGTGADMDVCLTNYGHCNYVSGKHACIFYDENTKHYELLNYSEHGTTVDNVLYSCDFSEKTPPTPPSSIVAKVQSVIRRRRHQKQDEEPSEEAAMMSSQAQGPQRRPCNCKASSSSLIGGSGAGWEGTALLHHGSYIKLGCLQFVFSITEFATKQPKGDASLLQDGVLAEKLSLKPHQGPVLRSNSVP", "length": 1003 }, "evidence": [ { "id": "E1B7A1", "url": "https://omabrowser.org/oma/group/E1B7A1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96QT6-1", "protein_name": "PHD finger protein 12", "gene_name": "PHF12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWEKMETKTIVYDLDTSGGLMEQIQALLAPPKTDEAEKRSRKPEKEPRRSGRATNHDSCDSCKEGGDLLCCDHCPAAFHLQCCNPPLSEEMLPPGEWMCHRCTVRRKKREQKKELGHVNGLVDKSGKRTTSPSSDTDLLDRSASKTELKAIAHARILERRASRPGTPTSSASTETPTSEQNDVDEDIIDVDEEPVAAEPDYVQPQLRRPFELLIAAAMERNPTQFQLPNELTCTTALPGSSKRRRKEETTGKNVKKTQHELDHNGLVPLPVKVCFTCNRSCRVAPLIQCDYCPLLFHMDCLEPPLTAMPLGRWMCPNHIEHVVLNQKNMTLSNRCQVFDRFQDTVSQHVVKVDFLNRIHKKHPPNRRVLQSVKRRSLKVPDAIKSQYQFPPPLIAPAAIRDGELICNGIPEESQMHLLNSEHLATQAEQQEWLCSVVALQCSILKHLSAKQMPSHWDSEQTEKADIKPVIVTDSSVTTSLQTADKTPTPSHYPLSCPSGISTQNSLSCSPPHQSPALEDIGCSSCAEKSKKTPCGTANGPVNTEVKANGPHLYSSPTDSTDPRRLPGANTPLPGLSHRQGWPRPLTPPAAGGLQNHTVGIIVKTENATGPSSCPQRSLVPVPSLPPSIPSSCASIENTSTLQRKTVQSQIGPPLTDSRPLGSPPNATRVLTPPQAAGDGILATTANQRFSSPAPSSDGKVSPGTLSIGSALTVPSFPANSTAMVDLTNSLRAFMDVNGEIEINMLDEKLIKFLALQRIHQLFPSRVQPSPGSVGTHQLASGGHHIEVQRKEVQARAVFYPLLGLGGAVNMCYRTLYIGTGADMDVCLTNYGHCNYVSGKHACIFYDENTKHYELLNYSEHGTTVDNVLYSCDFSEKTPPTPPSSIVAKVQSVIRRRRHQKQDEEPSEEAAMMSSQAQGPQRRPCNCKASSSSLIGGSGAGWEGTALLHHGSYIKLGCLQFVFSITEFATKQPKGDASLLQDGVLAEKLSLKPHQGPVLRSNSVP", "length": 1004 }, "evidence": [ { "id": "E1B7A1", "url": "https://omabrowser.org/oma/group/E1B7A1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9W410-1", "protein_name": "PHD finger protein 12", "gene_name": "PF1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSKLDQDPNASLSIMEQIKQLIRPPPNEDEKMMQRSTNTKHPYYRRPGRGHNHDYCDACEEGGNLLCCDRCPSSFHLQCHDPPLSEEDIPSGQWLCHSCRMSKLSQPPASSSKASSVERVPSAGSGSRANTPSSGDLESIPLKIRNLRKRSNSERNSTEKLLAKMPMSIQRALDPNKKPTPLDDVIRAATMMNPQQFSLPPELELHTQFPGNGKVQPVQQTHPPSGNGGNRRCAGNQRRNSKPFELDAQGLVPLPAKTCFYCTRSCKRAPLISCDYCPLYFHQDCLDPPLTALPAGLWMCPNHAENFIDANMTNSISATERVRLWNRFHQPLDHENVKLEFFRRVNTRNPPFRTKRNLRARAHIEVPAIVRYHYDHPPPLLPSMRQTLRYDRVKRRNNLPTEVEEISRESVTESLLKDLEALRTAHAKFREIQREFGTLETAIDGDSDSDPSPEEKRTETNTPADKVNGEVDTENPNTESNAQASEQPSVVKVESKTSLEVEASFEEDEEDSKKSTGIIDADLLHLDVDIIKKLAHQRLQQLVEEHPEIVTQYKNRTAARRLRQLASVDGTHVAGETAALQGQLAPEDMNRFSLLFTSETSSILAQKNGNAADEDPATALHPALATAAAIAAADAAAESYAPRARSDTEKAYELASRLELKLLQCKVQARAVITPLGDMLEDSRWFSSLGLDHSIFMRYRTLYIGYGGHYSPSTTLAQTETVDLSAIGYCCRISPQHAIIFYDEFSKSYELINYSEFGTEVNGQLYACDVTERMTTHAGKPMRPDDAELKKRVDEMLDKRRNINRQFETKKIDKERLAPIVKPACRCMNAGPVPMVDGAWEGSAVLAHGSLLRFGCLSFVFVVPSVDLLQAQARSKRS", "length": 878 }, "evidence": [ { "id": "E1B7A1", "url": "https://omabrowser.org/oma/group/E1B7A1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B7A1", "url": "https://www.uniprot.org/uniprotkb/E1B7A1" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "E1B7A1", "url": "https://www.uniprot.org/uniprotkb/E1B7A1" } ], "pmid": "" }, { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "E1B7A1", "url": "https://www.uniprot.org/uniprotkb/E1B7A1" } ], "pmid": "" }, { "name": "transcription corepressor binding", "id": "GO:0001222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001222", "evidence": [ { "database": "UniProtKB", "id": "E1B7A1", "url": "https://www.uniprot.org/uniprotkb/E1B7A1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "E1B7A1", "url": "https://www.uniprot.org/uniprotkb/E1B7A1" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1B7A1", "url": "https://www.uniprot.org/uniprotkb/E1B7A1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B7A1", "url": "https://www.uniprot.org/uniprotkb/E1B7A1" } ], "pmid": "" }, { "name": "transcription repressor complex", "id": "GO:0017053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017053", "evidence": [ { "database": "UniProtKB", "id": "E1B7A1", "url": "https://www.uniprot.org/uniprotkb/E1B7A1" } ], "pmid": "" }, { "name": "Sin3-type complex", "id": "GO:0070822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070822", "evidence": [ { "database": "UniProtKB", "id": "E1B7A1", "url": "https://www.uniprot.org/uniprotkb/E1B7A1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 328, "end_pos": 330, "annotation": "n_glycosylation_sequon" }, { "start_pos": 595, "end_pos": 597, "annotation": "n_glycosylation_sequon" }, { "start_pos": 606, "end_pos": 608, "annotation": "n_glycosylation_sequon" }, { "start_pos": 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"ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FHA", "eco_id": "ECO_0000259", "start_pos": 815, "end_pos": 869, "start_aa": "Leu", "end_aa": "Tyr", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B7A1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7A1" }, { "id": "PS50016", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50016" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PHD-type", "eco_id": "ECO_0000259", "start_pos": 56, "end_pos": 105, "start_aa": "His", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 880 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 170, 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"sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections. Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS. Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways. Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response.", "evidence": [ { "database": "UniProtKB", "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2#function" }, { "database": "UniProtKB", "id": "ARBA00058262", "url": "https://www.uniprot.org/uniprotkb/ARBA00058262#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRIM41", "url": "https://www.uniprot.org/uniprotkb/E1BBY2", "locus": { "chromosome": "7", "start_pos": 40371180, "end_pos": 40360305, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019646", "url": "https://www.ensembl.org/id/ENSBTAG00000019646" } ] } } ], "crossref": [ { "id": "E1BBY2", "url": "https://alphafold.ebi.ac.uk/entry/E1BBY2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019646", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019646", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13741", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13741", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19762", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19762", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006574", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006574", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M0C3", "url": "https://www.orthodb.org/?gene=A0A3Q1M0C3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BBY2", "url": "https://www.orthodb.org/?gene=E1BBY2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00643", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00643", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13765", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13765", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15227", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15227", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M0C3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0C3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0C3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0C3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBY2-1", "url": "https://www.uniprot.org/uniprotkb/E1BBY2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAVAMAPNPVQTLQEEAVCAICLDYFTDPVSIGCGHNFCRVCVTQLWGGEDEEDREELDREEEEEDAEEEEVEAVGAGGGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMGGSNWDNMDYVWEEEEEEEDLDYYLGDMEEDLRGEEEEDEEEVLEEDEEEELDPVTPLPPPPTPRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTAGRGSRGNEQGICPKHQEALKLFCEVDEEAICVVCRESRNHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKVVSTIPFASSQSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLSEQAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTDAIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRAVRLAERRQEVADHSKRFSADCCVLGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGSGGSSVGSGDASSSRHHHRRRRLHLPQQPLLQREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNAETLAHVHTFSAAFLGERVFPFFRVLSKGTRIKLCP", "length": 640, "header": "tr|E1BBY2-1|E1BBY2_BOVIN Isoform 1 of E3 ubiquitin-protein ligase TRIM41 OS=Bos taurus OX=9913 GN=TRIM41 PE=3 SV=4 CANONICAL=E1BBY2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0C3-1", "url": "https://www.uniprot.org/uniprotkb/E1BBY2/entry#A0A3Q1M0C3-1", "sequence": { "sequence": "MAAVAMAPNPVQTLQEEAVCAICLDYFTDPVSIGCGHNFCRVCVTQLWGGEDEEDREELDREEEEEDAEEEEVEAVGAGGGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMGGSNWDNMDYVWEEEEEEEDLDYYLGDMEEDLRGEEEEDEEEVLEEDEEEELDPVTPLPPPPTPRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTAGRGSRGNEQGICPKHQEALKLFCEVDEEAICVVCRESRNHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLSEQAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTDAIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRAVRLAERRQEVADHSKRFSADCCVLGAQGFRSGRHYWEVETGQNLASVRSGMVDMMETTYIIQLFLPPSFFSTNLGARLLPHPNPSGLFTTRLLSFSVKSPCQFPASFHVLISLHLVSPGGEPWDGFESLGEPWAESIFLVTLCLLSLISFCPLL", "length": 605, "header": "tr|A0A3Q1M0C3-1|E1BBY2_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase TRIM41 OS=Bos taurus OX=9913 GN=TRIM41 PE=3 SV=1 CANONICAL=E1BBY2-1" }, "locus": { "chromosome": "7", "start_pos": 40370176, "end_pos": 40360504, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080042.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080042.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061412.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061412.1" } ] } }, { "isoform_ac": "E1BBY2-1", "url": "https://www.uniprot.org/uniprotkb/E1BBY2/entry#E1BBY2-1", "sequence": { "sequence": "MAAVAMAPNPVQTLQEEAVCAICLDYFTDPVSIGCGHNFCRVCVTQLWGGEDEEDREELDREEEEEDAEEEEVEAVGAGGGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMGGSNWDNMDYVWEEEEEEEDLDYYLGDMEEDLRGEEEEDEEEVLEEDEEEELDPVTPLPPPPTPRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTAGRGSRGNEQGICPKHQEALKLFCEVDEEAICVVCRESRNHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKVVSTIPFASSQSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLSEQAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTDAIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRAVRLAERRQEVADHSKRFSADCCVLGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGSGGSSVGSGDASSSRHHHRRRRLHLPQQPLLQREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNAETLAHVHTFSAAFLGERVFPFFRVLSKGTRIKLCP", "length": 640, "header": "tr|E1BBY2-1|E1BBY2_BOVIN Isoform 1 of E3 ubiquitin-protein ligase TRIM41 OS=Bos taurus OX=9913 GN=TRIM41 PE=3 SV=4 CANONICAL=E1BBY2-1" }, "locus": { "chromosome": "7", "start_pos": 40369267, "end_pos": 40360504, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026179.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026179.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026179.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026179.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 175, "start_aa": "Thr", "end_pos": 175, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr175", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "response to other organism", "id": "GO:0051707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051707", "evidence": [ { "database": "UniProtKB", "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ], "pmid": "" }, { "name": "defense response", "id": "GO:0006952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006952", "evidence": [ { "database": "UniProtKB", "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ], "pmid": "" }, { "name": "positive regulation of signal transduction", "id": "GO:0009967", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009967", "evidence": [ { "database": "UniProtKB", "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ], "pmid": "" }, { "name": "cellular response to lipopolysaccharide", "id": "GO:0071222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071222", "evidence": [ { "database": "UniProtKB", "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ], "pmid": "" }, { "name": "cellular response to muramyl dipeptide", "id": "GO:0071225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071225", "evidence": [ { "database": "UniProtKB", "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ], "pmid": "" }, { "name": "positive regulation of type I interferon-mediated signaling pathway", "id": "GO:0060340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060340", "evidence": [ { "database": "UniProtKB", "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ], "pmid": "" }, { "name": "protein monoubiquitination", "id": "GO:0006513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006513", "evidence": [ { "database": "UniProtKB", "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BBY2", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983140" } ] }, { "id": "R-BTA-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1A4I9-1", "E1BJS7-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q1JQA1-1", "Q29RQ5-1", "Q32LN5-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0AAA9RXI4-1", "Q4U5R4-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983147" } ] }, { "id": "R-BTA-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983156" } ] }, { "id": "R-BTA-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1MAR8", "gene_name": "UBE2E1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] } ] }, { "uniprot_ac": "A0A3Q1MLB6", "gene_name": "UBE2R2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] } ] }, { "uniprot_ac": "A0A3Q1MLH2", "gene_name": "RNF144B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] } ] }, { "uniprot_ac": "A0A3Q1N3G7", "gene_name": "TRIM36", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] } ] }, { "uniprot_ac": "A0AAA9RXI4", "gene_name": "MGRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] } ] }, { "uniprot_ac": "A0AAA9RXX2", "gene_name": "RBBP6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] } ] }, { "uniprot_ac": "A0AAA9RZ14", "gene_name": "ITCH", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] } ] }, { "uniprot_ac": "A0AAA9S100", "gene_name": "MKRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] } ] }, { "uniprot_ac": "A0AAA9TKS8", "gene_name": "RNF217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] } ] }, { "uniprot_ac": "A0AAA9TWH7", "gene_name": "SMURF2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] } ] }, { "uniprot_ac": "A0AAF6DMH9", "gene_name": "RNF130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] } ] }, { "uniprot_ac": "A0ABI0NWC8", "gene_name": "UBE2Q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] } ] }, { "uniprot_ac": "A0JN74", "gene_name": "TRIM11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] } ] }, { "uniprot_ac": "A1A4I9", "gene_name": "UFL1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "A1A4I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I9" } ] } ] }, { "uniprot_ac": "A3KN22", "gene_name": "UBE2M", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] } ] }, { "uniprot_ac": "A5D7F8", "gene_name": "SH3RF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] } ] }, { "uniprot_ac": "A5PJC4", "gene_name": "UBE2L6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] } ] }, { "uniprot_ac": "A5PKG6", "gene_name": "UBE4A", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] } ] }, { "uniprot_ac": "A6H795", "gene_name": "UBE2W", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] } ] }, { "uniprot_ac": "E1B782", "gene_name": "HERC2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] } ] }, { "uniprot_ac": "E1B7D3", "gene_name": "TRIM39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] } ] }, { "uniprot_ac": "E1B7G3", "gene_name": "STUB1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] } ] }, { "uniprot_ac": "E1B7Q7", "gene_name": "TRIP12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] } ] }, { "uniprot_ac": "E1B8R6", "gene_name": "ARIH2", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] } ] }, { "uniprot_ac": "E1BAV2", "gene_name": "HERC4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] } ] }, { "uniprot_ac": "E1BBN5", "gene_name": "MIB2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] } ] }, { "uniprot_ac": "E1BBY2", "gene_name": "TRIM41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] } ] }, { "uniprot_ac": "E1BCU1", "gene_name": "UBE3B", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] } ] }, { "uniprot_ac": "E1BCW1", "gene_name": "UBR2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] } ] }, { "uniprot_ac": "E1BH71", "gene_name": "DTX3L", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] } ] }, { "uniprot_ac": "E1BID7", "gene_name": "TRIM69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] } ] }, { "uniprot_ac": "E1BIP5", "gene_name": "RNF19A", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] } ] }, { "uniprot_ac": "E1BIW0", "gene_name": "UBR1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] } ] }, { "uniprot_ac": "E1BJS7", "gene_name": "TRIM71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] } ] }, { "uniprot_ac": "E1BL26", "gene_name": "RNF123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] } ] }, { "uniprot_ac": "E1BNQ6", "gene_name": "TRIM50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] } ] }, { "uniprot_ac": "E1BNY9", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] } ] }, { "uniprot_ac": "F1MBM6", "gene_name": "SIAH2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] } ] }, { "uniprot_ac": "F1MEX6", "gene_name": "RNF19B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] } ] }, { "uniprot_ac": "F1MJ10", "gene_name": "NEDD4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] } ] }, { "uniprot_ac": "F1MJS5", "gene_name": "HECTD3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] } ] }, { "uniprot_ac": "F1MLS5", "gene_name": "SMURF1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] } ] }, { "uniprot_ac": "F1MM41", "gene_name": "ZNRF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] } ] }, { "uniprot_ac": "F1MTS8", "gene_name": "LTN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] } ] }, { "uniprot_ac": "F1MWS4", "gene_name": "RNF25", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] } ] }, { "uniprot_ac": "F1MYL0", "gene_name": "RNF220", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] } ] }, { "uniprot_ac": "F1N1X8", "gene_name": "UBE2Z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] } ] }, { "uniprot_ac": "F1N3I3", "gene_name": "UBE2O", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] } ] }, { "uniprot_ac": "F1N495", "gene_name": "AREL1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] } ] }, { "uniprot_ac": "F1N5G3", "gene_name": "SIAH1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] } ] }, { "uniprot_ac": "F1N645", "gene_name": "HECW2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] } ] }, { "uniprot_ac": "F1N6G5", "gene_name": "HACE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] } ] }, { "uniprot_ac": "F1N703", "gene_name": "UBE3C", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] } ] }, { "uniprot_ac": "F1N7A0", "gene_name": "HECTD2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] } ] }, { "uniprot_ac": "P61085", "gene_name": "UBE2K", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] } ] }, { "uniprot_ac": "Q0II22", "gene_name": "RNF126", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] } ] }, { "uniprot_ac": "Q0P5K3", "gene_name": "UBE2N", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] } ] }, { "uniprot_ac": "Q17QG5", "gene_name": "UBE2G2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] } ] }, { "uniprot_ac": "Q1JQA1", "gene_name": "UBE3D", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] } ] }, { "uniprot_ac": "Q1RML1", "gene_name": "UBE2S", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] } ] }, { "uniprot_ac": "Q1RMW1", "gene_name": "UBE2F", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] } ] }, { "uniprot_ac": "Q1RMX2", "gene_name": "UBE2D2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] } ] }, { "uniprot_ac": "Q29RQ5", "gene_name": "TRIM9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] } ] }, { "uniprot_ac": "Q2T9X7", "gene_name": "UBE2E3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] } ] }, { "uniprot_ac": "Q2TA03", "gene_name": "UBE2J2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] } ] }, { "uniprot_ac": "Q2TA10", "gene_name": "UBE2D1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] } ] }, { "uniprot_ac": "Q32L27", "gene_name": "UBE2Q2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] } ] }, { "uniprot_ac": "Q32LN1", "gene_name": "UBE2H", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] } ] }, { "uniprot_ac": "Q32LN5", "gene_name": "RNF138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] } ] }, { "uniprot_ac": "Q32P99", "gene_name": "UBE2B", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] } ] }, { "uniprot_ac": "Q32PA5", "gene_name": "UBE2C", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] } ] }, { "uniprot_ac": "Q3MHP1", "gene_name": "UBE2L3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] } ] }, { "uniprot_ac": "Q4U5R4", "gene_name": "RNF114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] } ] }, { "uniprot_ac": "Q5E9J6", "gene_name": "RNF34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] } ] }, { "uniprot_ac": "Q7YRV4", "gene_name": "TRIM21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRV4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRV4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBY2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 640, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBY2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBY2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" }, { "id": "PS50119", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50119" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B box-type", "eco_id": "ECO_0000259", "start_pos": 221, "end_pos": 262, "start_aa": "Asn", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" }, { "id": "PS50188", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50188" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B30.2/SPRY", "eco_id": "ECO_0000259", "start_pos": 423, "end_pos": 640, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 20, "end_pos": 61, "start_aa": "Cys", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA 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], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"https://www.uniprot.org/uniprotkb/E1BAS5", "locus": { "chromosome": "3", "start_pos": 105894662, "end_pos": 105974524, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019695", "url": "https://www.ensembl.org/id/ENSBTAG00000019695" } ] } } ], "crossref": [ { "id": "ENSBTAG00000019695", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019695", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "527058", "url": "https://www.ncbi.nlm.nih.gov/gene/527058", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052251", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052251", "database": "InterPro", "categories": [ "Protein 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"PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15507:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15507:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25420", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25420", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25580", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25580", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26218", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26218", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192868", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0Y2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Y2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0Y2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Y2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAS5", "url": "https://www.uniprot.org/uniprotkb/E1BAS5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAS5-1", "url": "https://www.uniprot.org/uniprotkb/E1BAS5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADGKGDAAATAGAGAEAPVGAGAGDGTETESMARGHSPASPAPVASGLRPCLWQLETELREQEVSEVSSLNYCRSFCQTLLQYASNKNASEHIVYLLEVYRLAIRSFASARPYLTTECEDVLLVLGRLVLSCFELLLSVSESELPCEAWVLFLQSLQESHDALLEFGNNNLQILVHVTKEGVWKNPVLLKILSQQPVETEEVNKLIAQEGPFFLQMRIKHLLKSNCIPQATALSKLCAESKEISNVSSFQQAYITCLCSILPNEDAIKEIAKVDCKEILDIICNLESEGQDNTAFVLCTTYLTQQLQTASVYCSWELTLFWSKLQRRIDPSVDTFLERCRQFGVIAKTQQHLFCLIRVIQTEAQDAGLGVSILLCVRALQLRTSEDEEMKASVCKTIACLLPEDLEVRRACQLTEFLIEPSLDGFNMLEELYSQPDQKFDEENAPVPNSLRCELLLALKAHWPFDPEFWDWKTLKRHCHQLLGQEASDSDDDLSGYEMSINDTDVLESFLSDYEEGKEDKQYRRRDVTDQHKEKRDKKPIGSSERYQRWLQYKFFCLLCKRECIEARILHHSKMHMEDGIYTCPVCIKKFKRKEIFVPHVMEHVKMPPSRRDRSRKKLLLKGSQKGICPKSPSAALEQGQSLNEQAKGESHEYVTFSKLEDCHLQDRDLYPCPGTDCSRVFKQFKYLSVHLKAEHQNNDENAKHYLDMKNRREKCTYCRRHFMSAFHLREHEQVHCGPQPYMCVSIDCYARFGSVNELLNHKQKHDDLRYKCELNGCNIVFSDLGQLYHHEAQHFRDASYTCNFVGCKKFYYSKIEYQNHLSMHNVESSNGDVKKTVKLEPAAGEKQDCIDQPHLLDQTDKSRLPEDLLFCAGSASSQIETTENLKENSDSNSSDQLSHSSSASMNEELIDTLDHSETMQDILLSHEKVFVPSSLKEKCSNVAVCFDGTKFTCGFDGCGSTYKNARGMQKHLRKVHPYHFKPKKVKTKDLFPCLGNEHNPTTEKFDAEPKPSSDTNSDSPDEGLDHNIHTKCKREHQGYSSEASICASKRPCTEDTMLELLLRLKHLSLKNSITHGSFSGSLQGYPSSGAKSLQAVSATISDLNFQNQDENMPSQYLAQLAAKPFFCELQGCKYEFVTREALLMHYLKKHNYSKEKVLQLTMFQHRYSPFQCHICQRSFTRKTHLRIHYKNKHQIGSDRVTQKLLDNEKCDHEGPCSVDRLKVDCPSELGGDPSGNSEKPHCHSKKDECSSETDLESSCEETESKISDLSSPIGSHREEGEGREGRGSRRTVAKGNLCYILNKYHKPFHCIHKTCNSSFTNLKGLIRHYRTVHQYNKEQLCLEKDKARTKRELVKCKKIFACKYKECNKRFLCSKALAKHCSDSHNLDHIEEPKVLSEAESVARFSCNQPQCPAVFYTFSKLKHHLMEQHNIEGEIHSDYEIHCDLNGCGQIFTHRSNYSQHVYYRHKDYYDDLFRSQKVANERLLRSEKVCQTAHPQGHEHQTTRKSFNAKAKKCGLIKDKKAPISFKTRAEALHMCVEHSEHTQYPCMVQGCLSVVKLESSIVRHYKRTHQMSSAYLEQQMENLVMCVKYGTKIKEEPISEAEPYIKKEEDGSCESELIQHSHPPADTSMPVQTADPLHPGERDGGQKGCIESNPVFDADSLLYRGTLKCNHSSETTSLEQCNIVQPPPCKIENSIPNPDGTESGTYFTSFQLPLPRIKDSETGQQSSGQENTVKNSTHVPKENFRKHPQPRSFDLKTYKPMGFESSFLKFIQESEEKEDDFDDWEPSEHLTLSNSSQPCNDLTGSVMANNMVNDNDPEVDIPHSSSDSAIHENLTAIPPLIVAETTTVPSLENLRVVLDKALTDCGELALKQLHYLRPVVVLERSKFSTPILDLFPTKKTDELCVGSS", "length": 1912, "header": "tr|E1BAS5-1|E1BAS5_BOVIN Isoform 1 of RLF zinc finger OS=Bos taurus OX=9913 GN=RLF PE=3 SV=3 CANONICAL=E1BAS5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0Y2-1", "url": "https://www.uniprot.org/uniprotkb/E1BAS5/entry#A0A3Q1M0Y2-1", "sequence": { "sequence": "MLGPETYLWSQCLLGPSKTLLQYASNKNASEHIVYLLEVYRLAIRSFASARPYLTTECEDVLLVLGRLVLSCFELLLSVSESELPCEAWVLFLQSLQESHDALLEFGNNNLQILVHVTKEGVWKNPVLLKILSQQPVETEEVNKLIAQEGPFFLQMRIKHLLKSNCIPQATALSKLCAESKEISNVSSFQQAYITCLCSILPNEDAIKEIAKVDCKEILDIICNLESEGQDNTAFVLCTTYLTQQLQTASVYCSWELTLFWSKLQRRIDPSVDTFLERCRQFGVIAKTQQHLFCLIRVIQTEAQDAGLGVSILLCVRALQLRTSEDEEMKASVCKTIACLLPEDLEVRRACQLTEFLIEPSLDGFNMLEELYSQPDQKFDEENAPVPNSLRCELLLALKAHWPFDPEFWDWKTLKRHCHQLLGQEASDSDDDLSGYEMSINDTDVLESFLSDYEEGKEDKQYRRRDVTDQHKEKRDKKPIGSSERYQRWLQYKFFCLLCKRECIEARILHHSKMHMEDGIYTCPVCIKKFKRKEIFVPHVMEHVKMPPSRRDRSRKKLLLKGSQKGICPKSPSAALEQGQSLNEQAKGESHEYVTFSKLEDCHLQDRDLYPCPGTDCSRVFKQFKYLSVHLKAEHQNNDENAKHYLDMKNRREKCTYCRRHFMSAFHLREHEQVHCGPQPYMCVSIDCYARFGSVNELLNHKQKHDDLRYKCELNGCNIVFSDLGQLYHHEAQHFRDASYTCNFVGCKKFYYSKIEYQNHLSMHNVESSNGDVKKTVKLEPAAGEKQDCIDQPHLLDQTDKSRLPEDLLFCAGSASSQIETTENLKENSDSNSSDQLSHSSSASMNEELIDTLDHSETMQDILLSHEKVFVPSSLKEKCSNVAVCFDGTKFTCGFDGCGSTYKNARGMQKHLRKVHPYHFKPKKVKTKDLFPCLGNEHNPTTEKFDAEPKPSSDTNSDSPDEGLDHNIHTKCKREHQGYSSEASICASKRPCTEDTMLELLLRLKHLSLKNSITHGSFSGSLQGYPSSGAKSLQAVSATISDLNFQNQDENMPSQYLAQLAAKPFFCELQGCKYEFVTREALLMHYLKKHNYSKEKVLQLTMFQHRYSPFQCHICQRSFTRKTHLRIHYKNKHQIGSDRVTQKLLDNEKCDHEGPCSVDRLKVDCPSELGGDPSGNSEKPHCHSKKDECSSETDLESSCEETESKISDLSSPIGSHREEGEGREGRGSRRTVAKGNLCYILNKYHKPFHCIHKTCNSSFTNLKGLIRHYRTVHQYNKEQLCLEKDKARTKRELVKCKKIFACKYKECNKRFLCSKALAKHCSDSHNLDHIEEPKVLSEAESVARFSCNQPQCPAVFYTFSKLKHHLMEQHNIEGEIHSDYEIHCDLNGCGQIFTHRSNYSQHVYYRHKDYYDDLFRSQKVANERLLRSEKVCQTAHPQGHEHQTTRKSFNAKAKKCGLIKDKKAPISFKTRAEALHMCVEHSEHTQYPCMVQGCLSVVKLESSIVRHYKRTHQMSSAYLEQQMENLVMCVKYGTKIKEEPISEAEPYIKKEEDGSCESELIQHSHPPADTSMPVQTADPLHPGERDGGQKGCIESNPVFDADSLLYRGTLKCNHSSETTSLEQCNIVQPPPCKIENSIPNPDGTESGTYFTSFQLPLPRIKDSETGQQSSGQENTVKNSTHVPKENFRKHPQPRSFDLKTYKPMGFESSFLKFIQESEEKEDDFDDWEPSEHLTLSNSSQPCNDLTGSVMANNMVNDNDPEVDIPHSSSDSAIHENLTAIPPLIVAETTTVPSLENLRVVLDKALTDCGELALKQLHYLRPVVVLERSKFSTPILDLFPTKKTDELCVGSS", "length": 1851, "header": "tr|A0A3Q1M0Y2-1|E1BAS5_BOVIN Computationally mapped isoform of RLF zinc finger OS=Bos taurus OX=9913 GN=RLF PE=3 SV=1 CANONICAL=E1BAS5-1" }, "locus": { "chromosome": "3", "start_pos": 105973676, "end_pos": 105895132, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068982.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068982.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063653.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063653.1" } ] } }, { "isoform_ac": "E1BAS5-1", "url": "https://www.uniprot.org/uniprotkb/E1BAS5/entry#E1BAS5-1", "sequence": { "sequence": "MADGKGDAAATAGAGAEAPVGAGAGDGTETESMARGHSPASPAPVASGLRPCLWQLETELREQEVSEVSSLNYCRSFCQTLLQYASNKNASEHIVYLLEVYRLAIRSFASARPYLTTECEDVLLVLGRLVLSCFELLLSVSESELPCEAWVLFLQSLQESHDALLEFGNNNLQILVHVTKEGVWKNPVLLKILSQQPVETEEVNKLIAQEGPFFLQMRIKHLLKSNCIPQATALSKLCAESKEISNVSSFQQAYITCLCSILPNEDAIKEIAKVDCKEILDIICNLESEGQDNTAFVLCTTYLTQQLQTASVYCSWELTLFWSKLQRRIDPSVDTFLERCRQFGVIAKTQQHLFCLIRVIQTEAQDAGLGVSILLCVRALQLRTSEDEEMKASVCKTIACLLPEDLEVRRACQLTEFLIEPSLDGFNMLEELYSQPDQKFDEENAPVPNSLRCELLLALKAHWPFDPEFWDWKTLKRHCHQLLGQEASDSDDDLSGYEMSINDTDVLESFLSDYEEGKEDKQYRRRDVTDQHKEKRDKKPIGSSERYQRWLQYKFFCLLCKRECIEARILHHSKMHMEDGIYTCPVCIKKFKRKEIFVPHVMEHVKMPPSRRDRSRKKLLLKGSQKGICPKSPSAALEQGQSLNEQAKGESHEYVTFSKLEDCHLQDRDLYPCPGTDCSRVFKQFKYLSVHLKAEHQNNDENAKHYLDMKNRREKCTYCRRHFMSAFHLREHEQVHCGPQPYMCVSIDCYARFGSVNELLNHKQKHDDLRYKCELNGCNIVFSDLGQLYHHEAQHFRDASYTCNFVGCKKFYYSKIEYQNHLSMHNVESSNGDVKKTVKLEPAAGEKQDCIDQPHLLDQTDKSRLPEDLLFCAGSASSQIETTENLKENSDSNSSDQLSHSSSASMNEELIDTLDHSETMQDILLSHEKVFVPSSLKEKCSNVAVCFDGTKFTCGFDGCGSTYKNARGMQKHLRKVHPYHFKPKKVKTKDLFPCLGNEHNPTTEKFDAEPKPSSDTNSDSPDEGLDHNIHTKCKREHQGYSSEASICASKRPCTEDTMLELLLRLKHLSLKNSITHGSFSGSLQGYPSSGAKSLQAVSATISDLNFQNQDENMPSQYLAQLAAKPFFCELQGCKYEFVTREALLMHYLKKHNYSKEKVLQLTMFQHRYSPFQCHICQRSFTRKTHLRIHYKNKHQIGSDRVTQKLLDNEKCDHEGPCSVDRLKVDCPSELGGDPSGNSEKPHCHSKKDECSSETDLESSCEETESKISDLSSPIGSHREEGEGREGRGSRRTVAKGNLCYILNKYHKPFHCIHKTCNSSFTNLKGLIRHYRTVHQYNKEQLCLEKDKARTKRELVKCKKIFACKYKECNKRFLCSKALAKHCSDSHNLDHIEEPKVLSEAESVARFSCNQPQCPAVFYTFSKLKHHLMEQHNIEGEIHSDYEIHCDLNGCGQIFTHRSNYSQHVYYRHKDYYDDLFRSQKVANERLLRSEKVCQTAHPQGHEHQTTRKSFNAKAKKCGLIKDKKAPISFKTRAEALHMCVEHSEHTQYPCMVQGCLSVVKLESSIVRHYKRTHQMSSAYLEQQMENLVMCVKYGTKIKEEPISEAEPYIKKEEDGSCESELIQHSHPPADTSMPVQTADPLHPGERDGGQKGCIESNPVFDADSLLYRGTLKCNHSSETTSLEQCNIVQPPPCKIENSIPNPDGTESGTYFTSFQLPLPRIKDSETGQQSSGQENTVKNSTHVPKENFRKHPQPRSFDLKTYKPMGFESSFLKFIQESEEKEDDFDDWEPSEHLTLSNSSQPCNDLTGSVMANNMVNDNDPEVDIPHSSSDSAIHENLTAIPPLIVAETTTVPSLENLRVVLDKALTDCGELALKQLHYLRPVVVLERSKFSTPILDLFPTKKTDELCVGSS", "length": 1912, "header": "tr|E1BAS5-1|E1BAS5_BOVIN Isoform 1 of RLF zinc finger OS=Bos taurus OX=9913 GN=RLF PE=3 SV=3 CANONICAL=E1BAS5-1" }, "locus": { "chromosome": "3", "start_pos": 105974325, "end_pos": 105895132, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026252.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026252.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026252.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026252.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:527058", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527058", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LLX4-1", "protein_name": "Zinc finger protein Rlf isoform X1", "gene_name": "Rlf", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MADGKGDATAAAGAGAGVEAPAVAGAGAGTETESMPRGHRPASPASGASGLRPCLWQLETELREQEVSEVSSLNYCRSFCQTLLQYASNKNASEHIVYLLEVYRLAIQSFASARPFLTTECEDVLLVLGRLVLSCFELLLSVPESELPCEVWVPFLQSLQESHDALLEFGNNNLQILVHVTKEGVWKNPVLLKILSQQPVETEEVNKLIAQEGPSFLQMRIKHLLKSNCIPQATALSKLCAESKELSQVSCFQQAYVTCLCSMLPSEEAIQEIAKVDCKEVLDIICNLESEGQDNTAFVLCTTYLTQQLQTASVYCSWELTLFWSKLQRRIDPSLETFLERCRQFGVIAKTQQHLFCLIRVIQTEAQDAGIGVSILLCVRALQLRSSEDEEMKASVCKTISCLLPEDLEVRRACQLTEFLIEPSLDGFNMLEELYLQPDQKFDEENAPVPNSLRCELLLALKAHWPFDPEFWDWKTLKRHCHQLLGQEASDSDDDLSGYEMSINDTDVLESFLSDYDESKEDKQYRRNLADQNKEKRDKKPIGSSERYQRWLQYKFFCLLCKRECIEARILHHSKMHMEDGIYTCPVCIKKFKRKELFVPHVMEHVKMPPSRRDRSRKKLLLKGSQRGIYPKSPTGSLEQNQSLSEQAKGESHEYVTFSKLEDRRLQDRDLYPCPGTDCSRVFKQFKYLSVHLKAEHQNNDENAKHYLDMKNRREKCTYCRRHFMSAFHLREHEQVHCGPQPYMCVSIDCYARFGSVNELLNHKQKHDDLRYKCELNGCNIVFSDLGQLYHHEAQHFRDASYTCNVVGCKKFYYSKIEYQNHLSMHNVESPDGELKKSVKLEEPAAGGKQDCVDQTHLLDQTDKSHSPEDHLFCAGSATAHIDTPENLKDNSDSNSSDQLSHSSSTSINEELIDTLDHSETMQDLLLSHEKVFVPSSLKEKCSNVAICFDGTKFTCGFDGCGSTYKNARGMQKHLRKVHPYHCKSRKVKTKDLFTCLGDKHNQADKFDAEPKPSSDTNSDSPDEGLDHSIHAKCKRDHRSYSPEPSICASKRPCTEDTMLELLLRLKHLSLKNSFSGSLQGCPSSGAKSLQSVPSSMSDLNLQNQDENMPSQYLAQLAAKPFFCELQGCKYEFVTREALLMHYLKKHNYSKEKVLQLTMFQHRYSPFRCHICQRSFTRKTHLRIHYKNKHQIGSDRATHRLLESEKCDHEGPCSVDRLKGDCSAELGPNSNSEMTQCHSKKDECSSETDLESSCEETESKVSGISSPIGSHREEGEGREGRGSRRTVAKGNLCYILNKYHKPFHCIHKTCNSSFTNLKGLIRHYRTVHQYNKEQLCLEKDKARTKRELVKCKKLFACKYKDCNKRFLCSKALAKHCSDSHNLDHIEESKVLSETESAARFSCNQPQCPAVFYSFSKLKQHLLEQHNIEGEIHSDYEIHCTLNGCGQIFSHRSNYFQHVYYRHKDSYDNLFSNQKVANERLLRSEKVCQTAEAQEQTQTEGQTQGQEQEQQTAKRPFNTKAKKCGLLKDKKAPISFKTRAEAIHMCVEHSEHTQYPCMVQGCMSVVKLESSIVRHYKRTHQMNSAYLEQQLENLVVCVKYGTKIKEEPPSEVEPCVKKEENTSCESVHTEHSPGDSSVPLQNADSTCPAQQDGDQKGCVERNSVLDADTLLYRGTLKCNHTSETTSLEQCDTVQSPPCKIESPIPNPSGTESSTYFTDFQLPLSRIKEEPGQHSSGQENTVKSATQVPKDNMRKHPQPRSFDLKTYKPMGFESSFLKFIQESEEKDDDFDDWEPSEHLPLNNSSQPANDLTGNVVANTVVNDSDPQVDIPHSSINPPVAENLTAVPPLVVAEAAAVPSLENLRVVLDKALTDCGELALKQLHYLRPVVVLERSKFSTPILDLFPTKKTDELCVGSS", "length": 1915 }, "evidence": [ { "id": "E1BAS5", "url": "https://omabrowser.org/oma/group/E1BAS5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0YP65-1", "protein_name": "RLF zinc finger", "gene_name": "RLF", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MARLVAALRGRLWQLQTELCEQEVSEASSRAYCRGFCQTLLHYAGSRGASEHILPFLEVYRISIQSFANARPYLTTECEDVLLVLGRLVLSCFELLLSIPESELPHEVWLEFHQSIQDSHDALLEFGNNNLQVLVDITREGVWKNPVLMKILSQQPVETEEANKLITREGPSFLQMRIKHLMKSNCIPQATFLSKLCADCPDIANVASFRQAYITCVCSMLPNEDSIKEIAKVDCKEVLDIICNLESEGQENTAFILCTTYLTHQLQTANVYCSWELTLFWSKLQRRIDPSLDSFLERCRQFGIIAKTLQHLFFLIRVIQSEAEEAGLAVSVLLCVRALQIRSNGSDEMKTSVCKTIACLLPEDLEVRRACQLTEFLLEPTLSGFNMLEELYMQPDQKFDEENALVPNSLRCELLLALKAYWPFDPEFWDWKTLKRHCLKLLGKAGSDSEDDASCNMSINETDMLETFFSDCDEAKDHKYYDGKDPINYHKEKARVKKPIGSSERYQRWLQYKFFCVLCKRECIEARILHHSKMHMEDGIYTCPVCTKKFKRKEFFVPHVMEHVKMPPSRTHRPKKKIILKKERSPQKTTASSSPTPTLQEKSHQPELSEAFGNDAHEYVTFSQLENCQLQDRDIYPCPGTDCSRVFKQFKYLSVHLKAEHQNNDENAKHYLDMKNRREKCAFCRRHFMTSFHLREHERVHCGPQPYMCVSMDCYARFGSVNELLNHKQTHDDLRYKCELNGCNIVFSDLGQLYHHEAQHFRDASYTCNFFGCKKFYYSKTEFQNHLAVHNIAVSNGEVKQTVKLEESQLLEQSENSHQNETLDPTGSEEIPQIKEEALSDSEDLDSESNCSLHCGNHSGTAAVNEGKVPPLLIETLAHGQTVPSFLMSREGVFHSADVKQQCSNAAVCFDEKKFSCGFEGCCSAHKNSRSVHKHLRRAHPYNFKGKKGMEVKTKDFLDVLSDAPESQSPTDISTEFGHKSDRNTDSPESSYCNVNAKGNNSFKEETYPSSPETSFYDSSKESSIEDNMLELMLGLKHLSLKNSNIQSSSRSKRVLGSLQSCSSRDTKCPESGVDATTSKFKFQEQQDNLPSQYLTQLAAKPFFCECQGCTCEFVTREALLMHYVKKHNYSKEMVLQLNMFQHRYSPFKCHICQRSFTRKTHLRIHYRNKHQIGCEQVAHKVCSNEKFDHVGLCTDDVHKNSAVPTPVCPTKVEFIDRSEQRCHPKKEECSSETDLESSEETDGNITRKSSKIATLDSHREELEAREGRGSKRTVAKGNLCYILHKYHKPFHCIHKSCNSAFTNQKGLIRHYRTVHQYNKEQLCLEKDKARTKRELVKCKKIFACKHKECGKRFFCSKDLAKHCSDFHNEHLDDQKLLAGTESARFACNQAQCPAVFCTFSKLKQHLIEEHASGERINKDFEIHCDLNGCNRIFTNYSHYSQHVYFRHSEYYDDLFGNQKEEQDNHDKNKSGQSCVRGGFGLNKQNGKRVKDKPKRTNRSKEKHLLSFKTKEEALQMCQENSNQTQYPCMVVGCLSVVKLESSILRHYKRTHQMTNMYIEQRIQKLVLCVKCGTMTEKQSCSEPALDLDKKDVEVKEEKSADPERPQEAEKSPVSNTDCQHQDVSSEEQKRCPPSSESFDPSAFTYSGTLNCSHGPKSSCSEEHNVRESVIGNSEELSENSERENSSYFSSLQLELPREKDAEGCEHSAVNQNAKRNVLFATKDKFQKPPVSRPFDLKTYKPMGFESSFLKFIQESEGKDDDDDDFDEVVEWESPEQLPVDRALQQEGEAQKDSPLNSCASDKSVVIPQSDPGQLTEMQPLLAEPSSAPSLENLRAILDKALTGCGDLALKQLHYLRPVVVLERSKFSTALIDLFPTKKADELCVGSM", "length": 1888 }, "evidence": [ { "id": "E1BAS5", "url": "https://omabrowser.org/oma/group/E1BAS5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A2A7F4-1", "protein_name": "Rearranged L-myc fusion sequence", "gene_name": "Rlf", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADGKGDATAAAGAGAGAEAPAVAGAEVETESMARGHRPASPASGAPGLRPCLWQLETELREQEVSEVSSLSYCRSFCQTLLQYASNKNASEHIVYLLEVYRLAIQSFASARPFLTTECEDVLLVLGRLVLSCFELLLSVSESELPCEVWVPFLQSLQESHDALLEFGNNNLQILVHVTKEGVWKNPILLKILSQQPVETEEVNKLIAQEGPSFLQMRIKHLLKSNCIPQATALSKLCAESKELAQVSCFQQAYITCLCSMLPSEEAIQEIAKVDCKDVLDIICNLESEGQDNTAFVLCTTYLTQQLQTASVYCSWELTLFWSKLQRRIDPSLETFLERCRQFGVIAKTQQHLFCLIRVIQTEAQDAGIGVSILLCVRALQLRSSEDEEMKASVCKTISCLLPEDLEVRRACQLTEFLIEPSLDGFNMLEELYLQPDQKFDEENAPVPNSLRCELLLALKAHWPFDPEFWDWKTLKRHCHQLLGQEASDSDDDLSGYEMSINDTDVLESFLSDYDDGKEDKQYRRSLTDQNKEKRDKKPIGSSERYQRWLQYKFFCLLCKRECIEARILHHSKMHMEDGIYTCPVCIKKFKRKELFVPHVMEHVKMPPSRSHRSRKKLLLKSAQRGIYPKSPTGSLEQNPEQARGESHEYVTFSKLEDRRLQDRDLYPCPGTDCSRVFKQFKYLSVHLKAEHQNNDENAKHYLDMKNRREKCTYCRRHFMSAFHLREHEQVHCGPQPYMCVSIDCYARFGSVNELLNHKQKHDDLRYKCELNGCNIVFSDLGQLYHHEAQHFRDASYTCNVLGCKKFYYSKIEYQNHLSMHNVESPDGELKKSVKLEEPGAGGKQDCVDQSHLLDETEKSHSLEDHHLCPGSASAHIDTTETLKDNSDSNSSDQLSHSSSTSITEELIDTLDHSETMQDLLLSHEKVFVPSSLKDKCSNVAVCFDGTKFTCGFDGCGSTYKNARGMQKHLRKVHPYHCKPRKIKTKDLFNCLDDKHNEADKFDAEPKPSSDTNSDSPDEGPDHSIHTKCKREHQGYSPEPSICASKRPCTEDTMLELLLRLKHLSLKNSIAHGSFSGSLQGCPSSGAKSLQSVPSSISDVNLQNQDENMPSQYLAQLAAKPFFCELQGCKYEFVTREALLMHYLKKHNYSKEKVLQLTMFQHRYSPFRCHICQRSFTRKTHLRIHYKNKHQIGSDRATHRLLDSEKCDHEGPCSVDRLKGDCSTELGPNSNSETTQCHSKKDECSSETDLESSCEETESKISGISSPIGSHREEGEEKEGRGSRRTVAKGNLCYILNKYHKPFHCIHKTCNSSFTNLKGLIRHYRTVHQYNKEQLCLEKDKARTKRELVKCKKLFACKYKDCNKRFLCSKALAKHCSDSHNLDHIEESKVLSETESAARFSCNQPQCPAVFYSFSKLKHHLLEQHNIEGEIHSDYEIHCTLNGCGQIFSHRSNYFQHVYYRHKDYYDNLFSSQKVANERLLRSEKVCQTTQAQGLTQTQGQTQGQTQGQEQQAAKRPFNTKAKKCGLLKDKKAPITFKTRAEAIHMCVEHSEHTQYPCMVQGCLSVVKLESSIVRHYKRTHQMNSAYLEQQLENLVVCVKYGTKIKDEPPSEVEPCVKKEESTSCESVHTENGAPGDSSVPLPNTDSTCPAEQDVGQKGCSERNPVFDTHSLLYRGTLKCNHSSETTSLEQCNIAQSSPCKIESPIPNPSGTESGTYFTDFQLPLPRIKEEPGQHSSGQENTVKNATQVPKENIRKHSQPRSFDLKTYKPMGFESSFLKFIQESEEKDDDFDDWEPSEHLTLNNSSHPSNDLTGNVVADTIVNESAPQVDIPHSSSDPPVSENLTAVPPLVVAEATAVPSLENLRVVLDKALTDCGELALKQLHYLRPVVVLERSKFSTPILDLFPTKKTDELCVGSS", "length": 1918 }, "evidence": [ { "id": "E1BAS5", "url": "https://omabrowser.org/oma/group/E1BAS5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZJX1-1", "protein_name": "RLF zinc finger", "gene_name": "Rlf", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADGKGDATAAAGAGAGAEAAAAAGAGTETESMARGHRPASPASGAPGLRPCLWQLETELREQEVSEVSSLNYCRSFCQTLLQYASNKNASEHIVYLLEVYRLAIQSFASARPFLTTECEDVLLVLGRLVLSCFELLLSVSESELPCEVWVPFLQSLQESHDALLEFGNNNLQILVHVTKEGVWKNPVLLKILSQQPVETEEVNKLIAQEGPSFLQMRIKHLLKSNCIPQATALSKLCAESKELAQVSCFQQAYVTCLCSMLPSEEAIQEIAKVDCKEVLDIICNLESEGQDNTAFVLCTTYLTQQLQTASVYCSWELTLFWSKLQRRTDPSLETFLERCRQFGVIAKTQQHLFCLIRVIQTEAQDAGIGVSILLCVRALQLRSSEDEEMKASVCKTISCLLPEDLEVRRACQLTEFLIEPSLDGFNMLEELYLQPDQKFDEENAPVPNSLRCELLLALKAHWPFDPEFWDWKTLKRHCHQLLGQEASDSDDDLSGYEMSINDTDVLESFLSDYDEGKEDKQYRRSLADQNKEKRDKKPIGSSERYQRWLQYKFFCLLCKRECIEARILHHSKMHMEDGVYTCPVCIKKFKRKELFVPHVMEHVKMPPSRSHRSRKKLLLKSSQSGIYPKSPTGSLEQNPSLSEQARGESHEYVTFSKLEDRRLQDRDLYPCPGTDCSRVFKQFKYLSVHLKAEHQNNDENAKHYLDMKNRREKCTYCRRHFMSAFHLREHEQVHCGPQPYMCVSIDCYARFGSVNELLNHKQKHDDLRYKCELNGCNIVFSDLGQLYHHEAQHFRDASYTCNVLGCKKFYYSKIEYQNHLSMHNVENPDGELKKSVKLEEPVAGEKQDCVDQSHLLEQTDKSHSPEDLLFCPGSASAHIDTTETLKDNSDSNSSDQLSPSSSTSITEELIDSLDHSETMQDLLLSDEKVFVPSSLKEKCSNVAVCFDGTKFTCGFDGCGSTYKNARGMQKHLRKVHPYHCKPRKIKTKDLFTCLDDKHNEADKFDAEPKPSSDTNSDSLDEGPDHSIHAKCKREHQGYSPEPSICASKRPCTEDTMLELLLRLKHLSLKNSIAHGSFSGSLQGCPSSGAKSLQSVPSSISDLNLQNQDENMPSQYLAQLAAKPFFCELQGCKYEFVTREALLMHYLKKHNYSKEKVLQLTMFQHRYSPFRCHICQRSFTRKTHLRIHYKNKHQIGSDRATHRLLDSEKCDHEGPCSVDRLTGDCSAELGPNSSSETTQCHSKKDECSSETDLESSCEETESKMCGISSPTGSHREEGEGKEGRGSRRTVAKGNLCYILNKYHKPFHCIHKTCNSSFTNLKGLIRHYRTVHQYNKEQLCLEKDKARTKRELVKCKKLFACKYKDCNKRFLCSKALAKHCSDSHNLDHIEESKVLSETESAARFSCNQPQCPAVFYSFSKLKHHLLEQHNIEGEIHSDYEIHCTLNGCGQIFSHRSNYFQHVYYRHKDYYDNLFSSQKVANERLLRSEKVCQTTQAQGLTQGQGQTQTQGQEQQAAKRPFNTKAKKCGLLKDKKAPISFKTRAEAIHMCVEHSEHTQYPCMVQGCLSVVKLESSIVRHYKRTHQMNSAYLEQQLENLVVCVKYGTKIKDEPPSEVEPCVKKEENASCESVRTESQSPGDSSVPLPNTDSTCPAEQDGGQKGCSERNPVFDTHSLLYRGTLKCNHSSETTSLEQCNIVQSPPCKIESPVANPSGTESGTYFTDFQLPLPRIKEEPGQHSSGQENTVKNATQVPKENIRKHSQPRSFDLKTYKPMGFESSFLKFIQESEEKDDDFDDWEPSEHLTLNNSSQPGNDLTGNVVADTIVNDSDPQVDIPHSSSDPAVPENLTAIPPLVVAEATAVPSLENLRVVLDKALTDCGELALKQLHYLRPVVVLERSKFSTPILDLFPTKKTDELCVGSS", "length": 1919 }, "evidence": [ { "id": "E1BAS5", "url": "https://omabrowser.org/oma/group/E1BAS5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q13129-1", "protein_name": "Zinc finger protein Rlf", "gene_name": "RLF", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADGKGDAAAVAGAGAEAPAVAGAGDGVETESMVRGHRPVSPAPGASGLRPCLWQLETELREQEVSEVSSLNYCRSFCQTLLQYASNKNASEHIVYLLEVYRLAIQSFASARPYLTTECEDVLLVLGRLVLSCFELLLSVSESELPCEVWLPFLQSLQESHDALLEFGNNNLQILVHVTKEGVWKNPVLLKILSQQPVETEEVNKLIAQEGPSFLQMRIKHLLKSNCIPQATALSKLCAESKEISNVSSFQQAYITCLCSMLPNEDAIKEIAKVDCKEVLDIICNLESEGQDNTAFVLCTTYLTQQLQTASVYCSWELTLFWSKLQRRIDPSLDTFLERCRQFGVIAKTQQHLFCLIRVIQTEAQDAGLGVSILLCVRALQLRSSEDEEMKASVCKTIACLLPEDLEVRRACQLTEFLIEPSLDGFNMLEELYLQPDQKFDEENAPVPNSLRCELLLALKAHWPFDPEFWDWKTLKRHCHQLLGQEASDSDDDLSGYEMSINDTDVLESFLSDYDEGKEDKQYRRRDLTDQHKEKRDKKPIGSSERYQRWLQYKFFCLLCKRECIEARILHHSKMHMEDGIYTCPVCIKKFKRKEMFVPHVMEHVKMPPSRRDRSKKKLLLKGSQKGICPKSPSAIPEQNHSLNDQAKGESHEYVTFSKLEDCHLQDRDLYPCPGTDCSRVFKQFKYLSVHLKAEHQNNDENAKHYLDMKNRREKCTYCRRHFMSAFHLREHEQVHCGPQPYMCVSIDCYARFGSVNELLNHKQKHDDLRYKCELNGCNIVFSDLGQLYHHEAQHFRDASYTCNFLGCKKFYYSKIEYQNHLSMHNVENSNGDIKKSVKLEESATGEKQDCINQPHLLNQTDKSHLPEDLFCAESANSQIDTETAENLKENSDSNSSDQLSHSSSASMNEELIDTLDHSETMQDVLLSNEKVFGPSSLKEKCSSMAVCFDGTKFTCGFDGCGSTYKNARGMQKHLRKVHPYHFKPKKIKTKDLFPSLGNEHNQTTEKLDAEPKPCSDTNSDSPDEGLDHNIHIKCKREHQGYSSESSICASKRPCTEDTMLELLLRLKHLSLKNSITHGSFSGSLQGYPSSGAKSLQSVSSISDLNFQNQDENMPSQYLAQLAAKPFFCELQGCKYEFVTREALLMHYLKKHNYSKEKVLQLTMFQHRYSPFQCHICQRSFTRKTHLRIHYKNKHQIGSDRATHKLLDNEKCDHEGPCSVDRLKGDCSAELGGDPSSNSEKPHCHPKKDECSSETDLESSCEETESKTSDISSPIGSHREEQEGREGRGSRRTVAKGNLCYILNKYHKPFHCIHKTCNSSFTNLKGLIRHYRTVHQYNKEQLCLEKDKARTKRELVKCKKIFACKYKECNKRFLCSKALAKHCSDSHNLDHIEEPKVLSEAGSAARFSCNQPQCPAVFYTFNKLKHHLMEQHNIEGEIHSDYEIHCDLNGCGQIFTHRSNYSQHVYYRHKDYYDDLFRSQKVANERLLRSEKVCQTADTQGHEHQTTRRSFNAKSKKCGLIKEKKAPISFKTRAEALHMCVEHSEHTQYPCMVQGCLSVVKLESSIVRHYKRTHQMSSAYLEQQMENLVVCVKYGTKIKEEPPSEADPCIKKEENRSCESERTEHSHSPGDSSAPIQNTDCCHSSERDGGQKGCIESSSVFDADTLLYRGTLKCNHSSKTTSLEQCNIVQPPPPCKIENSIPNPNGTESGTYFTSFQLPLPRIKESETRQHSSGQENTVKNPTHVPKENFRKHSQPRSFDLKTYKPMGFESSFLKFIQESEEKEDDFDDWEPSEHLTLSNSSQSSNDLTGNVVANNMVNDSEPEVDIPHSSSDSTIHENLTAIPPLIVAETTTVPSLENLRVVLDKALTDCGELALKQLHYLRPVVVLERSKFSTPILDLFPTKKTDELCVGSS", "length": 1914 }, "evidence": [ { "id": "E1BAS5", "url": "https://omabrowser.org/oma/group/E1BAS5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BAS5", "url": "https://www.uniprot.org/uniprotkb/E1BAS5" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BAS5", "url": "https://www.uniprot.org/uniprotkb/E1BAS5" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BAS5", "url": "https://www.uniprot.org/uniprotkb/E1BAS5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BAS5", "url": "https://www.uniprot.org/uniprotkb/E1BAS5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BAS5", "url": "https://www.uniprot.org/uniprotkb/E1BAS5" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BAS5", "url": "https://www.uniprot.org/uniprotkb/E1BAS5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1152, "end_pos": 1154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1317, "end_pos": 1319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1459, "end_pos": 1461, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1674, "end_pos": 1676, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1739, "end_pos": 1741, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1798, "end_pos": 1800, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1837, "end_pos": 1839, "annotation": "n_glycosylation_sequon" }, { "start_pos": 246, "end_pos": 248, "annotation": "n_glycosylation_sequon" }, { "start_pos": 502, "end_pos": 504, "annotation": "n_glycosylation_sequon" }, { "start_pos": 893, "end_pos": 895, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS5" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 582, "end_pos": 609, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1152, "end_pos": 1154 }, { "start_pos": 1317, "end_pos": 1319 }, { "start_pos": 1459, "end_pos": 1461 }, { "start_pos": 1674, "end_pos": 1676 }, { "start_pos": 1739, "end_pos": 1741 }, { "start_pos": 1798, "end_pos": 1800 }, { "start_pos": 1837, "end_pos": 1839 }, { "start_pos": 246, "end_pos": 248 }, { "start_pos": 502, "end_pos": 504 }, { "start_pos": 893, "end_pos": 895 }, { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BBB7-1", "uniprot_ac": "E1BBB7", "uniprot_id": "E1BBB7_BOVIN", "mass": { "chemical_mass": 41810.0, "monoisotopic_mass": 41810.0 }, "refseq": { "ac": "XP_024845876", "name": "LIM/homeobox protein Lhx8 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845876" }, "gene_names": [ { "name": "LHX8", "type": "recommended", "evidence": [ { "id": "E1BBB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBB7" } ] }, { "name": "LHX8", "type": "synonym", "evidence": [ { "id": "XP_024845876", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845876" } ] } ], "protein_names": [ { "name": "LIM homeobox 8", "type": "synonym", "evidence": [ { "id": "E1BBB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBB7/entry#names_and_taxonomy" } ] }, { "name": "LIM/homeobox protein Lhx8 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024845876", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845876" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBB7", "url": "https://www.uniprot.org/uniprotkb/E1BBB7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LHX8", "url": "https://www.uniprot.org/uniprotkb/E1BBB7", "locus": { "chromosome": "3", "start_pos": 69636164, "end_pos": 69662316, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019192", "url": "https://www.ensembl.org/id/ENSBTAG00000019192" } ] } } ], "crossref": [ { "id": "ENSBTAG00000019192", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019192", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09381", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09381", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09383", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09383", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512385", "url": "https://www.ncbi.nlm.nih.gov/gene/512385", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050453", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050453", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DPMFVCK", "url": "https://omabrowser.org/oma/group/DPMFVCK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M1Y4", "url": "https://www.orthodb.org/?gene=A0A3Q1M1Y4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BBB7", "url": "https://www.orthodb.org/?gene=E1BBB7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24208", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24208", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24208:SF117", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24208:SF117", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024845876", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845876", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1Y4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Y4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1Y4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Y4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBB7", "url": "https://www.uniprot.org/uniprotkb/E1BBB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBB7-1", "url": "https://www.uniprot.org/uniprotkb/E1BBB7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYWKSDQMFVCKLEEKDVLELAVPLEKCQGLMSEECGRTAALAAGRTRKGAGEEGLVSPEGVGDEDSCSSSAPLSPSSSPRSMASGSVCPPGKCVCSSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSRCGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHYDCMLDNLKREVENGNGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRARHKKHVSPNHSSSAPVTAVPPSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDAHSPTTLGLQPLLPHSMTQLPISHT", "length": 377, "header": "tr|E1BBB7-1|E1BBB7_BOVIN Isoform 1 of LIM homeobox 8 OS=Bos taurus OX=9913 GN=LHX8 PE=4 SV=3 CANONICAL=E1BBB7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M1Y4-1", "url": "https://www.uniprot.org/uniprotkb/E1BBB7/entry#A0A3Q1M1Y4-1", "sequence": { "sequence": "MYWKSDQMFVCKLEEKDVLELAVPLEKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRYGTRCSRCGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHYDCMLDNLKREVENGNGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRARHKKHVSPNHSSSAPVTAVPPSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDAHSPTTLGLQPLLPHSMTQLPISHT", "length": 293, "header": "tr|A0A3Q1M1Y4-1|E1BBB7_BOVIN Computationally mapped isoform of LIM homeobox 8 OS=Bos taurus OX=9913 GN=LHX8 PE=4 SV=3 CANONICAL=E1BBB7-1" }, "locus": { "chromosome": "3", "start_pos": 69662093, "end_pos": 69636694, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079551.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079551.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063763.3", "url": "https://www.ensembl.org/id/ENSBTAP00000063763.3" } ] } }, { "isoform_ac": "E1BBB7-1", "url": "https://www.uniprot.org/uniprotkb/E1BBB7/entry#E1BBB7-1", "sequence": { "sequence": "MYWKSDQMFVCKLEEKDVLELAVPLEKCQGLMSEECGRTAALAAGRTRKGAGEEGLVSPEGVGDEDSCSSSAPLSPSSSPRSMASGSVCPPGKCVCSSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSRCGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHYDCMLDNLKREVENGNGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRARHKKHVSPNHSSSAPVTAVPPSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDAHSPTTLGLQPLLPHSMTQLPISHT", "length": 377, "header": "tr|E1BBB7-1|E1BBB7_BOVIN Isoform 1 of LIM homeobox 8 OS=Bos taurus OX=9913 GN=LHX8 PE=4 SV=3 CANONICAL=E1BBB7-1" }, "locus": { "chromosome": "3", "start_pos": 69662093, "end_pos": 69636694, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025544.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025544.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025544.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025544.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1P4G9-1", "protein_name": "LIM homeobox 8", "gene_name": "LHX8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MYWKSDPMFVCRLEDKDLPALGDTSEKESPAAADEDSCSSSAALSPSSSPRSMASGSGCAPSKCVCSSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSRCGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHYDCMLDNLKREVENGNGVSMEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRARHKKHVSPNHSSTAPVTAAQPSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDAHSPTALGLQPLLPHSMTQLPISHT", "length": 347 }, "evidence": [ { "id": "E1BBB7", "url": "https://omabrowser.org/oma/group/E1BBB7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3V6V6-1", "protein_name": "LIM homeobox 8", "gene_name": "Lhx8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYWKSDQMFVCKLEGKDVPELAVPREKCPGLMSEECGRPAALAAGRTRKGAGEEGLVNPEGAGDEDSCSSSAPLSPSSSPQSMASGSVCPPGKCVCSSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSRCGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHFDCMLDNLKREVENGNGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRARHKKHVSPNHSSSAPVTAVPSSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDAHQQLLDSSPCYPIQ", "length": 367 }, "evidence": [ { "id": "E1BBB7", "url": "https://omabrowser.org/oma/group/E1BBB7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O35652-1", "protein_name": "LIM/homeobox protein Lhx8", "gene_name": "Lhx8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYWKSDQMFVCKLEGKEVPELAVPREKCPGLMSEECGRPAALAAGRTRKGAGEEGLVNPEGAGDEDSCSSSAPLSPSSSPQSMASGSVCPPGKCVCSSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSRCGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHFDCMLDNLKREVENGNGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRARHKKHVSPNHSSSAPVTAVPSSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDAHQQLLDSSPCYPIQ", "length": 367 }, "evidence": [ { "id": "E1BBB7", "url": "https://omabrowser.org/oma/group/E1BBB7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q68G74-1", "protein_name": "LIM/homeobox protein Lhx8", "gene_name": "LHX8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQILSRCQGLMSEECGRTTALAAGRTRKGAGEEGLVSPEGAGDEDSCSSSAPLSPSSSPRSMASGSGCPPGKCVCNSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSRCGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHYDCMLDNLKREVENGNGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRARHKKHVSPNHSSSTPVTAVPPSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDAHSPTTLGLQPLLPHSMTQLPISHT", "length": 356 }, "evidence": [ { "id": "E1BBB7", "url": "https://omabrowser.org/oma/group/E1BBB7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BBB7", "url": "https://www.uniprot.org/uniprotkb/E1BBB7" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BBB7", "url": "https://www.uniprot.org/uniprotkb/E1BBB7" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BBB7", "url": "https://www.uniprot.org/uniprotkb/E1BBB7" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "E1BBB7", "url": "https://www.uniprot.org/uniprotkb/E1BBB7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BBB7", "url": "https://www.uniprot.org/uniprotkb/E1BBB7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BBB7", "url": "https://www.uniprot.org/uniprotkb/E1BBB7" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BBB7", "url": "https://www.uniprot.org/uniprotkb/E1BBB7" } ], "pmid": "" }, { "name": "neuron differentiation", "id": "GO:0030182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182", "evidence": [ { "database": "UniProtKB", "id": "E1BBB7", "url": "https://www.uniprot.org/uniprotkb/E1BBB7" } ], "pmid": "" }, { "name": "forebrain neuron development", "id": "GO:0021884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021884", "evidence": [ { "database": "UniProtKB", "id": "E1BBB7", "url": "https://www.uniprot.org/uniprotkb/E1BBB7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBB7" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 244, "end_pos": 304, "start_aa": "Lys", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BBB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBB7" }, { "id": "PS50023", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50023" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LIM zinc-binding", "eco_id": "ECO_0000259", "start_pos": 94, "end_pos": 154, "start_aa": "Cys", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 308, "end_pos": 310 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BB26-1", "uniprot_ac": "E1BB26", "uniprot_id": "E1BB26_BOVIN", "mass": { "chemical_mass": 224288.0, "monoisotopic_mass": 224288.0 }, "refseq": { "ac": "XP_002691329", "name": "HEAT repeat-containing protein 5B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691329" }, "gene_names": [ { "name": "HEATR5B", "type": "recommended", "evidence": [ { "id": "E1BB26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB26" } ] }, { "name": "HEATR5B", "type": "synonym", "evidence": [ { "id": "XP_002691329", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691329" } ] } ], "protein_names": [ { "name": "HEAT repeat-containing protein 5B", "type": "recommended", "evidence": [ { "id": "E1BB26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB26/entry#names_and_taxonomy" } ] }, { "name": "HEAT repeat-containing protein 5B isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002691329", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691329" } ] } ], "function": [ { "annotation": "Component of clathrin-coated vesicles. Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes.", "evidence": [ { "database": "UniProtKB", "id": "E1BB26", "url": "https://www.uniprot.org/uniprotkb/E1BB26#function" }, { "database": "UniProtKB", "id": "ARBA00056585", "url": "https://www.uniprot.org/uniprotkb/ARBA00056585#function" }, { "database": "UniProtKB", "id": "A0A3Q1M3S3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3S3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BB26", "url": "https://www.uniprot.org/uniprotkb/E1BB26" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HEATR5B", "url": "https://www.uniprot.org/uniprotkb/E1BB26", "locus": { "chromosome": "11", "start_pos": 19439551, "end_pos": 19541542, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014310", "url": "https://www.ensembl.org/id/ENSBTAG00000014310" } ] } } ], "crossref": [ { "id": "ENSBTAG00000014310", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014310", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540503", "url": "https://www.ncbi.nlm.nih.gov/gene/540503", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046837", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046837", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540503", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540503", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YPQVIQE", "url": "https://omabrowser.org/oma/group/YPQVIQE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M3S3", "url": "https://www.orthodb.org/?gene=A0A3Q1M3S3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N7P6", "url": "https://www.orthodb.org/?gene=A0A3Q1N7P6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BB26", "url": "https://www.orthodb.org/?gene=E1BB26", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21663", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21663", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21663:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21663:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF20210", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20210", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25468", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25468", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002691329", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691329", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3S3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3S3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3S3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3S3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N7P6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7P6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N7P6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7P6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB26", "url": "https://www.uniprot.org/uniprotkb/E1BB26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB26-1", "url": "https://www.uniprot.org/uniprotkb/E1BB26-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELAHSLLLNEEALAQITEAKRPVFIFEWLRFLDKVLVAANKTDVKEKQKKLVEQLTGLISSSPGPPTRKLLAKNLAALYSIGDTFTVFQTLDKCNDIIRNKDDTAAYLPTKLAAVACVGAFYEKMGRMLGSAFPETVNNLLKSLKSAESQGRSEILMSLQKVLNGLGGAAASCHRDIYKNARSLLTDRSMAVRCAVAKCLLELQNEAVFMWTAELENIATLCFKALENSNYGVRVAVSKLLGTVMATALMPKQATVMRQNVKRATFDEVLELMATGFLRGGSGFLKSGGEMLKVGGSVNREVRVGVTQAYVVFVTTLGGQWLERSFATFLSHVLDLVSHPRATQTHVEAVYSRRCVSFILRATVGSLLGEKAQIAAAKEICQAIGKQMKAVEAVVNDTSGENKSGAADIAASQHVMVCALQELGSLVQSLNATASPLIQEASIGLLETVTSVLLHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNSLKTSPEAVSGYSFAMAALLGGVHQCPLGIPHAKGKMVVSIAEDLLRTAAQNSRLSLQRTQAGWLLLGALMTLGPSVVRYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFVAHCPELLTEDVIRKLMTPIECAMTMMSHIPSVIKAHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEFTLTDNSANTTTSLLRSLCHYDDSVLLGSWLQETDHKSIEDQLQPNSASGSGALEHDPSSIYLRIPAGEAVPGPLPLGVSVIDASVALFGVVFPHVSFKHRLQMLDHFAECVKQAKGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSALTLVMGALDNPNPILRCAAGEALGRMAQVVGEATFIARMAQYSFDKLKSARDVVSRTGHSLALGCLHRYVGGIGSGQHLKTSVSILLALAQDGTSSEVQTWSLHSLALIVDSSGPMYRGYVEPTLSLVLTLLLTVPPSHTEVHQCLGRCLGAIITTVGPELQGNGATISTIRSSCLVGCAITQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRRAAVACLRQLAQREAAEVCEYAMSLAKSSGDKESSGTNVSPFAPGASSRSDIHCRHQGVNITETGLEGLLFGMLDRETDRKLCSDIHDTLGHMLSSLAVEKLSHWLMLCKDVLAASSDMSTATPLSSGKDEEFEKKDEMDDDTMFTTLGEEDKSKPFVAPRWATRVFAADCLCRIINLCENADQAHFDLAMARSAKLRNPTNDLLVLHLSDLIRMAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQYQANVGAALRPAFSQDTPSDIIAKACQVCSTWIGSGVVSDLNDLRRVHNLLVSSLDKVQAGKGSSSQLYRESATTMEKLAVLKAWAEVYVVAMNIKKEAESKPKRAVKNTDDDDDDDSTIDELPPDSLITLVQPELPILSRLWLAALKDYALLTLPAEFASQLPPDGGAFYTPETIDTARLHYRNSWAPILHAVALWLNSTGFTCSESAEAAAISALQKRSIPVNLSQASGAIPSAKSLAEINKDRMHLILGVSIQFLCSPRPEEPVEHVTACLQALHTLLDSPYARIHIAEDQLIGVELLSVLHRLLLTWNPPSVQLLVTGVVQQIVRAAQDYLQEKRNTLNEDDIEKESCPVLGEGGDSGGLIPGKSLVFATLELLMFILVRHMPHLSTKMSDSPSHIATKTRLSEESARLVAATVTILSDLPSLCSPAGCMTILPTILFLIARILKDTAIKSADNQVPPPVSAALQGIKSIVTLSMAKTEDTQKQWTALIRSTLACILEYSQPEDSVPVPDEVSMLTAIALFLWSAGSEIIGVQSLQNGCIYRFKNALNSCDPWVQAKCYQLLLSVFQHSNRALSTPYIHSLAPIVVEKLKAVERNRPGSSTELLAVQEGIKVLETLVALGEEQNRVQLLALLVPTLISYLLDENSFASASTASKDLHEFALQNLMHIGPLYPHAFKTVMGAAPELKVRLETAVRASQASKAKVATRQPAPTVHSAPTIKLKTSFF", "length": 2070, "header": "tr|E1BB26-1|E1BB26_BOVIN Isoform 1 of HEAT repeat-containing protein 5B OS=Bos taurus OX=9913 GN=HEATR5B PE=3 SV=2 CANONICAL=E1BB26-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M3S3-1", "url": "https://www.uniprot.org/uniprotkb/E1BB26/entry#A0A3Q1M3S3-1", "sequence": { "sequence": "MELAHSLLLNEEALAQITEAKRPVFIFEWLRFLDKVLVAANKTDVKEKQKKLVEQLTGLISSSPGPPTRKLLAKNLAALYSIGDTFTVFQTLDKCNDIIRNKDDTAAYLPTKLAAVACVGAFYEKMGRMLGSAFPETVNNLLKSLKSAESQGRSEILMSLQKVLNGLGGAAASCHRDIYKNARSLLTDRSMAVRCAVAKCLLELQNEAVFMWTAELENIATLCFKALENSNYGVRVAVSKLLGTVMATALMPKQATVMRQNVKRATFDEVLELMATGFLRGGSGFLKSGGEMLKVGGSVNREVRVGVTQAYVVFVTTLGGQWLERSFATFLSHVLDLVSHPRATQTHVEAVYSRRCVSFILRATVGSLLGEKAQIAAAKEICQAIGKQMKAVEAVVNDTSGENKSGAADIAASQHVMVCALQELGSLVQSLNATASPLIQEASIGLLETVTSVLLHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNSLKTSPEAVSGYSFAMAALLGGVHQCPLGIPHAKGKMVVSIAEDLLRTAAQNSRLSLQRTQAGWLLLGALMTLGPSVVRYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFVAHCPELLTEDVIRKLMTPIECAMTMMSHIPSVIKAHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEFTLTDNSANTTTSLLRSLCHYDDSVLLGSWLQETDHKSIEDQLQPNSASGSGALEHDPSSIYLRIPAGEAVPGPLPLGVSVIDASVALFGVVFPHVSFKHRLQMLDHFAECVKQAKGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSALTLVMGALDNPNPILRCAAGEALGRMAQVVGEATFIARMAQYSFDKLKSARDVVSRTGHSLALGCLHRYVGGIGSGQHLKTSVSILLALAQDGTSSEVQTWSLHSLALIVDSSGPMYRGYVEPTLSLVLTLLLTVPPSHTEVHQCLGRCLGAIITTVGPELQGNGATISTIRSSCLVGCAITQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRRAAVACLRQLAQREAAEVCEYAMSLAKSSGDKESSGTNDLLVLHLSDLIRMAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQYQANVGAALRPAFSQDTPSDIIAKACQVCSTWIGSGVVSDLNDLRRVHNLLVSSLDKVQAGKGSSSQLYRESATTMEKLAVLKAWAEVYVVAMNIKKEAESKPKRAVKNTDDDDDDDSTIDELPPDSLITLVQPELPILSRLWLAALKDYALLTLPAEFASQLPPDGGAFYTPETIDTARLHYRNSWAPILHAVALWLNSTGFTCSESAEAAAISALQKRSIPVNLSQASGAIPSAKSLAEINKDRMHLILGVSIQFLCSPRPEEPVEHVTACLQALHTLLDSPYARIHIAEDQLIGVELLSVLHRLLLTWNPPSVQLLVTGVVQQIVRAAQDYLQEKRNTLNEDDIEKESCPVLGEGGDSGGLIPGKSLVFATLELLMFILVRHMPHLSTKMSDSPSHIATKTRLSEESARLVAATVTILSDLPSLCSPAGCMTILPTILFLIARILKDTAIKSADNQVPPPVSAALQGIKSIVTLSMAKTEDTQKQWTALIRSTLACILEYSQPEDSVPVPDEVSMLTAIALFLWSAGSEIIGVQSLQNGCIYRFKNALNSCDPWVQAKCYQLLLSVFQHSNRALSTPYIHSLAPIVVEKLKAVERNRPGSSTELLAVQEGIKVLETLVALGEEQNRVQLLALLVPTLISYLLDENSFASASTASKDLHEFALQNLMHIGPLYPHAFKTVMGAAPELKVRLETAVRASQASKAKVATRQPAPTVHSAPTIKLKTSFF", "length": 1906, "header": "tr|A0A3Q1M3S3-1|E1BB26_BOVIN Computationally mapped isoform of HEAT repeat-containing protein 5B OS=Bos taurus OX=9913 GN=HEATR5B PE=3 SV=2 CANONICAL=E1BB26-1" }, "locus": { "chromosome": "11", "start_pos": 19541520, "end_pos": 19440555, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081290.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081290.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068182.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068182.2" } ] } }, { "isoform_ac": "A0A3Q1N7P6-1", "url": "https://www.uniprot.org/uniprotkb/E1BB26/entry#A0A3Q1N7P6-1", "sequence": { "sequence": "MSLQKVLNGLGGAAASCHRDIYKNARSLLTDRSMAVRCAVAKCLLELQNEAVFMWTAELENIATLCFKALENSNYGVRVAVSKLLGTVMATALMPKQATVMRQNVKRATFDEVLELMATGFLRGGSGFLKSGGEMLKVGGSVNREVRVGVTQAYVVFVTTLGGQWLERSFATFLSHVLDLVSHPRATQTHVEAVYSRRCVSFILRATVGSLLGEKAQIAAAKEICQAIGKQMKAVEAVVNDTSGENKSGAADIAASQHVMVCALQELGSLVQSLNATASPLIQEASIGLLETVTSVLLHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNSLKTSPEAVSGYSFAMAALLGGVHQCPLGIPHAKGKMVVSIAEDLLRTAAQNSRLSLQRTQAGWLLLGALMTLGPSVVRYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFVAHCPELLTEDVIRKLMTPIECAMTMMSHIPSVIKAHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEFTLTDNSANTTTSLLRSLCHYDDSVLLGSWLQETDHKSIEDQLQPNSASGSGALEHDPSSIYLRIPAGEAVPGPLPLGVSVIDASVALFGVVFPHVSFKHRLQMLDHFAECVKQAKGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSALTLVMGALDNPNPILRCAAGEALGRMAQVVGEATFIARMAQYSFDKLKSARDVVSRTGHSLALGCLHRYVGGIGSGQHLKTSVSILLALAQDGTSSEVQTWSLHSLALIVDSSGPMYRGYVEPTLSLVLTLLLTVPPSHTEVHQCLGRCLGAIITTVGPELQGNGATISTIRSSCLVGCAITQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRRAAVACLRQLAQREAAEVCEYAMSLAKSSGDKESSGTNVSPFAPGASSRSDIHCRHQGVNITETGLEGLLFGMLDRETDRKLCSDIHDTLGHMLSSLAVEKLSHWLMLCKDVLAASSDMSTATPLSSGKDEEFEKKDEMDDDTMFTTLGEEDKSKPFVAPRWATRVFAADCLCRIINLCENADQAHFDLAMARSAKLRNPTNDLLVLHLSDLIRMAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQYQANVGAALRPAFSQDTPSDIIAKACQVCSTWIGSGVVSDLNDLRRVHNLLVSSLDKVQAGKGSSSQLYRESATTMEKLAVLKAWAEVYVVAMNIKKEAESKPKRAVKNTDDDDDDDSTIDELPPDSLITLVQPELPILSRLWLAALKDYALLTLPAEFASQLPPDGGAFYTPETIDTARLHYRNSWAPILHAVALWLNSTGFTCSESAEAAAISALQKRSIPVNLSQASGAIPSAKSLAEINKDRMHLILGVSIQFLCSPRPEEPVEHVTACLQALHTLLDSPYARIHIAEDQLIGVELLSVLHRLLLTWNPPSVQLLVTGVVQQIVRAAQDYLQEKRNTLNEDDIEKESCPVLGEGGDSGGLIPGKSLVFATLELLMFILVRHMPHLSTKMSDSPSHIATKTRLSEESARLVAATVTILSDLPSLCSPAGCMTILPTILFLIARILKDTAIKSADNQVPPPVSAALQGIKSIVTLSMAKTEDTQKQWTALIRSTLACILEYSQPEDSVPVPDEVSMLTAIALFLWSAGSEIIGVQSLQNGCIYRFKNALNSCDPWVQAKCYQLLLSVFQHSNRALSTPYIHSLAPIVVEKLKAVERNRPGSSTELLAVQEGIKVLETLVALGEEQNRVQLLALLVPTLISYLLDENSFASASTASKDLHEFALQNLMHIGPLYPHAFKTVMGAAPELKVRLETAVRASQASKAKVATRQPAPTVHSAPTIKLKTSFF", "length": 1913, "header": "tr|A0A3Q1N7P6-1|E1BB26_BOVIN Computationally mapped isoform of HEAT repeat-containing protein 5B OS=Bos taurus OX=9913 GN=HEATR5B PE=3 SV=2 CANONICAL=E1BB26-1" }, "locus": { "chromosome": "11", "start_pos": 19530706, "end_pos": 19440555, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079556.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079556.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066825.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066825.2" } ] } }, { "isoform_ac": "E1BB26-1", "url": "https://www.uniprot.org/uniprotkb/E1BB26/entry#E1BB26-1", "sequence": { "sequence": "MELAHSLLLNEEALAQITEAKRPVFIFEWLRFLDKVLVAANKTDVKEKQKKLVEQLTGLISSSPGPPTRKLLAKNLAALYSIGDTFTVFQTLDKCNDIIRNKDDTAAYLPTKLAAVACVGAFYEKMGRMLGSAFPETVNNLLKSLKSAESQGRSEILMSLQKVLNGLGGAAASCHRDIYKNARSLLTDRSMAVRCAVAKCLLELQNEAVFMWTAELENIATLCFKALENSNYGVRVAVSKLLGTVMATALMPKQATVMRQNVKRATFDEVLELMATGFLRGGSGFLKSGGEMLKVGGSVNREVRVGVTQAYVVFVTTLGGQWLERSFATFLSHVLDLVSHPRATQTHVEAVYSRRCVSFILRATVGSLLGEKAQIAAAKEICQAIGKQMKAVEAVVNDTSGENKSGAADIAASQHVMVCALQELGSLVQSLNATASPLIQEASIGLLETVTSVLLHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNSLKTSPEAVSGYSFAMAALLGGVHQCPLGIPHAKGKMVVSIAEDLLRTAAQNSRLSLQRTQAGWLLLGALMTLGPSVVRYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFVAHCPELLTEDVIRKLMTPIECAMTMMSHIPSVIKAHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEFTLTDNSANTTTSLLRSLCHYDDSVLLGSWLQETDHKSIEDQLQPNSASGSGALEHDPSSIYLRIPAGEAVPGPLPLGVSVIDASVALFGVVFPHVSFKHRLQMLDHFAECVKQAKGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSALTLVMGALDNPNPILRCAAGEALGRMAQVVGEATFIARMAQYSFDKLKSARDVVSRTGHSLALGCLHRYVGGIGSGQHLKTSVSILLALAQDGTSSEVQTWSLHSLALIVDSSGPMYRGYVEPTLSLVLTLLLTVPPSHTEVHQCLGRCLGAIITTVGPELQGNGATISTIRSSCLVGCAITQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRRAAVACLRQLAQREAAEVCEYAMSLAKSSGDKESSGTNVSPFAPGASSRSDIHCRHQGVNITETGLEGLLFGMLDRETDRKLCSDIHDTLGHMLSSLAVEKLSHWLMLCKDVLAASSDMSTATPLSSGKDEEFEKKDEMDDDTMFTTLGEEDKSKPFVAPRWATRVFAADCLCRIINLCENADQAHFDLAMARSAKLRNPTNDLLVLHLSDLIRMAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQYQANVGAALRPAFSQDTPSDIIAKACQVCSTWIGSGVVSDLNDLRRVHNLLVSSLDKVQAGKGSSSQLYRESATTMEKLAVLKAWAEVYVVAMNIKKEAESKPKRAVKNTDDDDDDDSTIDELPPDSLITLVQPELPILSRLWLAALKDYALLTLPAEFASQLPPDGGAFYTPETIDTARLHYRNSWAPILHAVALWLNSTGFTCSESAEAAAISALQKRSIPVNLSQASGAIPSAKSLAEINKDRMHLILGVSIQFLCSPRPEEPVEHVTACLQALHTLLDSPYARIHIAEDQLIGVELLSVLHRLLLTWNPPSVQLLVTGVVQQIVRAAQDYLQEKRNTLNEDDIEKESCPVLGEGGDSGGLIPGKSLVFATLELLMFILVRHMPHLSTKMSDSPSHIATKTRLSEESARLVAATVTILSDLPSLCSPAGCMTILPTILFLIARILKDTAIKSADNQVPPPVSAALQGIKSIVTLSMAKTEDTQKQWTALIRSTLACILEYSQPEDSVPVPDEVSMLTAIALFLWSAGSEIIGVQSLQNGCIYRFKNALNSCDPWVQAKCYQLLLSVFQHSNRALSTPYIHSLAPIVVEKLKAVERNRPGSSTELLAVQEGIKVLETLVALGEEQNRVQLLALLVPTLISYLLDENSFASASTASKDLHEFALQNLMHIGPLYPHAFKTVMGAAPELKVRLETAVRASQASKAKVATRQPAPTVHSAPTIKLKTSFF", "length": 2070, "header": "tr|E1BB26-1|E1BB26_BOVIN Isoform 1 of HEAT repeat-containing protein 5B OS=Bos taurus OX=9913 GN=HEATR5B PE=3 SV=2 CANONICAL=E1BB26-1" }, "locus": { "chromosome": "11", "start_pos": 19541520, "end_pos": 19440555, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019031.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019031.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019031.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019031.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540503", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540503", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0B4KGF6-1", "protein_name": "HEAT repeat-containing protein 5A", "gene_name": "Heatr5", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MENLNFARTPQFLRKVISEARRSFINSDHFSASSTRGRSETEEEAISEMELAHTLILNEDALKQLPEHKRPVFELEWLRYLEKALPLVSKAEIKASQKKLVQQLSERIQGAPGPPIRKLIASALATLFSVGDTFMLFDTVNACNDILKNKDDSPSYLPTKLAAICVLGSMYEKLGRMMGRTYEDTVQILIRTLRNAESQARIEIMHTLEKVSAGMGTAIANVHKDIYKAAKHCLLDRVMAVRVAAARCILKMIYSAPFLYQTELESLGTLCFRAFDGSNYEVRCAVAQLLGTLLAYTQQLAEAATSKKKQGQAVAIQAGKGATQRLVSLDEALGILMSGFLRGGASFLKGTGEIIKGSSGVNREVRVGVTHAYVVFVQFMGSVWLERQLSTFLAHVLDLVANPKAACSHVDAVYSRKCISFILRSTIGKMLGEKAQSAACKELVHLVAKQMNSIDFNPENAKDSNQETLFSQHLLVCALQELSSLLIGLGTTAQNLLGDQSLQAIDATCAVLVHPCAAARLAAAWCLRCACVAVPGQITPLIDRFVEAIEQMRSSPEAMAGYSCALAAILGSVRYSPLGIPHTKGKVVFNCAEELLRSASQNSRMSLHRTQAGWLLIGAIMTLGSPVVKGLLPRMLLLWRNSFPRSNKELESEKARGDAFTWQVTLEGRAGALSVMHSFLLNCPDLLNEDITRRLLTPIESALAMLVNLASVLKSYGTQLKAPAAMVRLRLFETLTLLPANALEASYTHLLRMLVSEFTLSDNAANTTNSLLRTLCHGDDSIILGTWLQETNHRTIEDQMEPNRKVDGEHLQPNSAAGSGALEHDPCCLYRPRSAQGNGSSSNGSSATSTGGSNGGGGSNIQQISKAQQCPGPLPLGVAVIDMAVTLYGTIFPKVANKHRLQMLEHFTECIRQAKSSRQEAVQMNIFTALLCALKNLTDSKTSLGQEDVRKSATALIVASLTSANSTIRCAAGEALGRLAQVVGDSHFTAELAQNSFDKLKSARDVVTRTGHSHALGCLHRYVGGMGSSQHLSTSVSILLALGQDSASPVVQAWSLYALAQIADSGGPMFRGYVEATLTLCLKLLLTVPHAHVDVHQCVGRVVNALITTVGPELQGGGGAVATMRGSFLCSAALLQSHSDPLVQAEAIGCLQQLHLFASKSLQLEELVPTLVGMLACNYFILRKASVSCLRQLAHREAKEVCELALTINAEQLPDLVITEYGLPGLLFSLLDTETDAEMLRNIHDTLTSMLQMLAADNLSSWLSLCKNVLTVAVEGGLNDDPAAGEQSKSKEAGGEDDEEDEEEEYADDVTEYRAEENTSTHPAVQPRWPTRVFAAQCVRRIIASCEAASSVHFDLLQAKEQQLIRSRGDYLILHLAELIRMSFMAATSDSDQLRLEGLRTLQEIIDRFANVPEPEFPGHLLLEQFQAQVGAALRPAFAPDTPSHVTAAACEVCSAWIGSGVARDIGDLKRVHQLLVSSLDKLSSKTNSTQLYNESMATLEKLSILKAWAEVYIVAMIGNGKAPASLLNLQSQQSGFQSLTNLETDSDVPDSRGESLLGLVQPELHNLSTHWLSAMKDHALLLLPAEFQSQLPHDGGAFYTTDTINSSKPHYMTSWPPILYASALWLRDEGFARHLDTSEAAAESNNNQITHGSLSADRFHMIFGICMEALCSMRSSERPRNIVSCLRSLHSIFDSDWARRQLVKDRALTIELCHVLHRQILTRDELLVQLLCVEILKQTIRAAREDLERKRDDNANSEDGKGGERHGEDDSMQPGSSHVYAVLEVCLCLFVRQIPTMNPTRQGAGGSGLQLDFAYAKMATGSSFFSVLGDENGLLVSSGLQCVEQLMDLCTPKGALAILPTVLYMTTSIVKEIANKSAIDSTILANTCAVKSALQCLRSVCVHKWAKVEETTEEWQQLLQSALATIVDLTKTAGDNEERKVDEVTMLLAITVFILHTPASVVATPSLQYPCINHFRQCLQSENLSVKLRCIETTRSIFARAELKTATPYIHALAPRIIESLYAESSKVPTSELELQVTLESIVTVEQLIDLSEPQNRNMNLLQDIQMLTLLVPVLIGFLAEPSRLRTLPKYQRQLHDQALQWLLKIGPKYPQEFKALMGQTPELRQKLEAAIRSQQQSINIAQKASEAQRNLLAKPQKPTIKLKTDFSNFQ", "length": 2172 }, "evidence": [ { "id": "E1BB26", "url": "https://omabrowser.org/oma/group/E1BB26/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "A0A0R4ISV1-1", "protein_name": "HEAT repeat-containing protein 5B", "gene_name": "heatr5b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MELAHSLLLNEEALSHITEAKRAVFIFEWLRFLDKVLIAANKVDVKEKQKKLVEQLTGLISSSPGPPTRKLLAKNLAVLYSIGDTFTVFQTLDKCNDIIKSKDDTAAYLPSKLAAVACVGAFYERMGRMLGSSFPETINNLLKALKSAEAQGRGEILLSLQKVLSGLGGAAASCHRDIYKNTRSMLSDRSMAVRCAVARCLLELQNEAVFIWTTELENVATLCFKALEGSTYDVRVAVSTLLGTVMATALMPKQATVMRQNVKRATLEEVLELMATGFLRGGSGFLKSGGEMLKGASVSREVRVGVTQAYVVFVTVLGGQWLERNFAVFLSHLLELVAHPRATQTHVEAVYSRRCVSFALRATLGGLLGEKAQIAAAKEICLAISKQMRAVEAVVNEQSSENRTGAADVSASQHVMVCALKELGRLVQSLSATASPLIQEPSIGLLETVLSVLLHPSMAARLAAAWCLRCVCVALPHQLTPLLERCADCINTLKNSPEAVSGYSFAMAALLGGVHQCPLGVPHSKGKMVVSIAEDLLRSAAQNSRLSLQRTQAGWLLLGALMTLGPSLVRYHLPKMLLLWRNVFPRSQKELEAEKARGDSFSWQVMLEGRAGALCAMRSFVAHCPELLTEDVIRRLMTPIECAMTMMSHIPAVIKVHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEFTLTDNSANTTTSLLRSLCHYDDSVLMGSWLQETDHKSIEDQLQPNSASGSGALEHDPSSIYLRVPAVEAVPGPLPLGVSVIDASVALFGVVFPHVSFKHRLQMLDHFAECIKQAKGVRQQAVQLNIFTAVLSALKGLAENKSSLGLEEVRKSALALVMGALDNSNPILRCAAGEALGRMAQVVGEASFIARMAQHSFDKLKSARDVVSRTGHSLALGCLHRYVGGIGSGQHLKTSVSILLALAQDATCHEVQTWALHSLALIVDSSGPMYRGYVEPTLSLVLTLLLTVPPSHTEVHQCLGRCLGALITTVGPELQGNSVSISTIRSSCLVGCAIMQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRRAAVACLRQMAQREAAEVCEYAMSLARRAGDTKDNSTTNLNITETGLEGVLFGMLDRETDRKLCSDIHDTLGHMLSSLAVEKLSHWLKLCKDVLAATTEVGGAVASDSRRKDDDEDSEKKDEMDDDIMFTSLGQDEKMKATVAPRWVTRVFAAECLCRIIHLCENADHAHFHLAEARIAKIKNPEADFLVLHLCDLIRMAFMAATDHSNQLRMAGLQALEDIIKKFAAVPDPEFPSHVILEQYQANVGAALRPAFSPDTPSDITAKACQVCSAWIGSGVVSDLNDLRRVHNLLVSSLDKVQTGKSSSSQLYSESATTMEKLAVLKAWAEVFVVAMDIKQESRARPVRPPAGEDEDEDEAADVLPPDSLMVLVQPELPSLSRLWLELLRDYALLTLPAEFSSQLPADGGAFYTPETIDTARLHYRSSWASVLHAEALWLSSTGFGITEDSAASGAAVQPAKHPEELVKDRLHLLLGISIEFLCFPRAEEPIEDVMSCLRAVCTLLDSPIARTHIAEDQLLAVELLNVLHRLLLTRDPSSVQLQVTAVVQKTIHAAQEHLEQRRSNKGGVNEDGVCVLGEGADSGELLPGKSLVFAAMELLVFILVRHLPQLKEKNTDTCRRSPQSLSEHSSRLVANSVTALAELPSLCSPAGSMTILPTVLFLITGVLRETAVKTADNSVSAPVSAALQAIKTILSSTAAHTHAQWSALVRSSLATVLEDSQPSDSVDEVSFLAAITLFLLSASGDLMSVCVLQKGCIERFTHALNSADPWTQARCCQLLLSILQQPSRSLSVPFIHTLAPLLVEQLKSVERRRVCNAAELQAVQERVRVMETLVNMAEEHNRVQLLALLVPTLVSYLLDDSSFSSSSSSSKGLHDFALQSLMHTGPLYPAAFMTVIGAAPELKTRLEAAIRSKQAHSRAKSTARQTLPAAPAAPTIKLKTSFF", "length": 2025 }, "evidence": [ { "id": "E1BB26", "url": "https://omabrowser.org/oma/group/E1BB26/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8C2LNN2-1", "protein_name": "HEAT repeat-containing protein 5B", "gene_name": "Heatr5b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MELAHSLLLNEEALAQITEAKRPVFIFEWLRFLDKVLVAANKTDVKEKQKKLVEQLTGLISSSPGPPTRKLLAKNLAALYSIGDTYTVFQTLDKCNDIIRSKDDTAAYLPTKLAAVACVGAFYEKMGRMLGSAFPETVNNLLKSLKSAESQGRSEILMSLQKVLTGLGGAAASCHRDIYKNARSLLTDRSMAVRCAVAKCLLELQNEAVFMWTAELENIATLCFKALENSNYGVRVAVSKLLGTVMATALMPKQATVMRQNVKRATFDEVLELMATGFLRGGSGFLKSGGEMLKVGGSVNREVRVGVTQAYVVFVTALGGQWLERSFATFLSHVLDLVSHPRATQTHVDAVYSRRCVSFILRATVGSLLGEKAQIAAAKEICQAIGKQMKAVEAVVNDTSSENKSGAADIAASQHVMVCALQELGSLVQSLNATASPLIQEASIGLLEIVTSVLLHPSMAARLAAAWCLRCVAVALPFQVTPFLDRCAERLNNLKTSPEAVSGYSFAMAALLGGVHQCPLGIPHAKGKMVVSIAEDLLRTAAQNSRLSLQRTQAGWLLLGALMTLGPSVVRYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFVAHCPELLTEDAIRKLMTPIECAMTMMSHIPSVIKAHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEFTLTDNSANTTTSLLRSLCHYDDSVLLGSWLQETDHKSIEDQLQPNSASGSGALEHDPSSIYLRIPAGEAVPGPLPLGVSVIDASVALFGVVFPHVSYKHRLQMLDHFAECVKQAKGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSALTLVMGALDNPNPILRCAAGEALGRMAQVVGEASFIARMAQYSFDKLKSARDVVSRTGHSLALGCLHRYVGGIGSGQHLKTSVSILLALAQDGTSPEVQTWSLHSLALIVDSSGPMYRGYVEPTLSLVLTLLLTVPPSHTEVHQCLGRCLGAIITTVGPELQGNAATISTIRSSCLVGCAITQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRRAAVACLRQLAQREAAEVCEYAMSLAKNAGDKESGGANVSPFLPGVSHRGDIHCRHQGVNITDTGLEGLLFGMLDRETDRKLCSDIHDTLGHMLSSLAVEKLSHWLMLCKDVLAASSDMSTATLLSSGKDEESEKKDEMDDDTMFTTLGEEDKSKPFVAPRWATRVFAADCLCRIINLCENSDQAHFDLAMARSAKLRNPKNDLLVLHLSDLIRMAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQYQANVGAALRPAFSQDTPSDIIAKACQVCSTWIGSGVVSDLNDLRRVHNLLVSSLDKVQAGKGSSSQLYRESATTMEKLAVLKAWAEVYVVAMNIKKEAESKPKRAMRTPDDDDDDYGTIDELPPDSLITLVQPELPTLSRLWLAALKDYALLTLPAEFSSQLPPDGGAFYTPETIDTARLHYRNSWAPILHAVALWLNSTGFTCPESTEAAAVSGTQKRSLAVGLNQVPGAMASAKPLPEVNKGRMHLILGVSIQFLCSPRPEEPIEHVTACLQALHTLLGSPYARIHIAEDQLIGVELLSVLHRLLLTWNPPSIQLLVTGVVQQIVGAAQDHLQEKRNTINEEDMEKESCPTLGEGGDSGGLIPGKSLVFSTMELLMFILVRHMPHLSTKMSDSPSHGTTKTRLSEESARLVAATVAILSDLPSLCSPAGCMTILPTILFLIARILKDTAIKSADNQVPPPVSAALQGIKSIVTLSMAKTKETQKQWTSLIRSTLACILEYSQPDDSMPAPDEVSTLTAIALFLWSASSEIIGVQSLQNGCMNRFKSALNSCDPWVQAKCYQLLLSVFQHANRALSTPYIHSLAPLVVEKLKAVERNRPASSTELLAVQEGIKVLETLVALGEDQNRVQLLALLVPTLISYLLDENSFASASSVSKDLHEFALQNLMHIGPLYPHAFKTVMGAAPELKVRLETAVRASQASQAKAAARQPAPATHSAPTIKLKTSFF", "length": 2070 }, "evidence": [ { "id": "E1BB26", "url": "https://omabrowser.org/oma/group/E1BB26/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0ABK0LGW6-1", "protein_name": "HEAT repeat-containing protein 5B", "gene_name": "Heatr5b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCEVRTSIMELAHSLLLNEEALAQITEAKRPVFIFEWLRFLDKVLVAANKTDVKEKQKKLVEQLTGLISSSPGPPTRKLLAKNLAALYSIGDTYTVFQTLDKCNDIIRSKDDTAAYLPTKLAAVACVGAFYEKMGRMLGSAFPETVNNLLKSLKSAESQGRSEILMSLRKVLTGLGGAAASSHRDIYKNARSLLTDRSMAVRCAVAKCLLELQNEAVFMWTAELENIATLCFKALENSNYGVRVAVSKLLGTVMATALMPKQATVMRQNVKRATFDEVLELMATGFLRGGSGFLKSGGEMLKVGGSVNREVRVGVTQAYVVFVTTLGGQWLERSFATFLSHVLDLVSHPRATQTHVDAVYSRRCVSFILRATVGSLLGEKAQIAAAKEICQAIGKQMKAVEAVVNDTSSENKSGAADIAASQHVMVCALQELGSLVQSLNATASPLIQEASIGLLEIVTSVLLHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNNLKTSPEAVSGYSFAMAALLGGVHQCPLGIPHAKGKMVVSIAEDLLRTAAQNSRLSLQRTQAGWLLLGALMTLGPSVVRYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFVAHCPELLTEDAVRKLMTPIECAMTMMSHIPSVIKAHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEFTLTDNSANTTTSLLRSLCHYDDSVLLGSWLQETDHKSIEDQLQPNSASGSGALEHDPSSIYLRIPAGEAVPGPLPLGVSVIDASVALFGVVFPHVSYKHRLQMLDHFAECVKQAKGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSALTLVMGALDNPNPILRCAAGEALGRMAQVVGEASFIARMAQYSFDKLKSARDVVSRTGHSLALGCLHRYVGGIGSGQHLKTSVSILLALAQDGTSPEVQTWSLHSLALIVDSSGPMYRGYVEPTLSLVLTLLLTVPPSHTEVHQCLGRCLGAIITTVGPELQGNAATISTIRSSCLVGCAITQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRRAAVACLRQLAQREAAEVCEYAMSLAKNAGDKEISGGNVSPFAPGVSSRSDIHCRHQGVNITDTGLEGLLFGMLDRETDRKLCSDIHDTLGHMLSSLAVEKLSHWLTLCKDVLAASSDMSAATLLSSGKDEESEKKDEMDDDAMFTTLGEEDKSKPFVAPRWATRVFAADCLCRIINLCENADQAHFDLALARSAKLRNPKNDLLVLHLSDLIRMAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQYQANVGAALRPAFSQDTPSDIIAKACQVCSTWIGSGVVSDLNDLRRVHNLLVSSLDKVQAGKGSPSQLYRESATTMEKLAVLKAWAEVYVVAMNIKKEAESKPKRAMKNTDDDDDDFGTIDELPPDSLITLVQPELPTLSRLWLAALKDYALLTLPAEFSSQLPPDGGAFYTPETIDTARLHYRNSWAPILHAVALWLNSTGFTCQESTEATAVSGGQKRSPAVSLNQVPGAMASAKPLPEVNKDRMHLILGVSIQFLCSPRPEEPIEHVTACLQALHTLLGSPYARIHIAEDQLIGVELLSVLHRLLLTWNPPSIQLLVTGVVQQIVRAAQDYLQEKRSALNEEDMEKESCPALGEGGDTGGLIPGKSLVFATMELLMFILVRHMPHLSTKMSDSPSHVATKTHLSEESARLVAATVTILSDLPSLCSPAGCMTILPTILFLIARILKDTAIKSVDNHVSPPVSAALQGIKSIVTLSMAKTEETQKQWTALIRSTLACILEYSQPDDCMPAPDEVSTLTAIALFLWSASSEIIGVQSLQNGCMNRFKSALNSCDPWVQAKCYQLLLSVFQHSNRALSTPYIHSLAPLVVGKLKAVERDRPASSTELLAVQEGIKVLETLVALGEEQNRVQLLALLVPTLISYLLDENSFASASSISKDLHEFALQNLMHIGPLYPHAFKTVMGAAPELKARLETAVRASQASKAKAAARQPAPATHSAPTIKLKTSFF", "length": 2078 }, "evidence": [ { "id": "E1BB26", "url": "https://omabrowser.org/oma/group/E1BB26/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1C8J1-1", "protein_name": "HEAT repeat-containing protein 5B", "gene_name": "HEATR5B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MELAHSLLLNEEALAQITEAKRPVFIFEWLRFLDKVLVAANKTDVKEKQKKLVEQLTGLISSSPGPPTRKLLAKNLAALYSIGDTFTVFQTLDKCNDIIKSKDDTAAYLPTKLAAVACVGAFYEKMGRMLGSAFPETVNNLLKSLKSAESQGRSEILMSLQKVLNGLGGAAASCHRDIYKNARSLLTDRSMAVRCAVAKCLLELQNEAVFMWTAELENVATLCFKALENSNYGVRVAVSKLLGTVMATALIPKQATVMRQNVKRATLEEVLELMATGFLRGGSGFLKSGGEMLKVGGSVNREVRVGVTQAYVVFVTTLGGQWLERNFATFLSHVLDLVSHPRATQTHVEAVYSRRCVSFILRATVGSLLGEKAQIAAAKDICQAIGKQMKAVEAVVNDANSENKAGAADVAASQHVMVCALQELGSLVQSLNATASPLIQEPSIGLLETVTSVLLHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNNLKTSPEAVSGYSFAMAALLGGVHQCPLGIPHAKGKMVVSIAEDLLRTAAQNSRLSLQRTQAGWLLLGALMTLGPSVVRYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFVAHCPELLTEDVIRKLMTPIECAMTMMSHIPSVIKAHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEFTLTDNSANTTTSLLRSLCHYDDSVLLGSWLQETDHKSIEDQLQPNSASGSGALEHDPSSIYLRIPAGEAVPGPLPLGVSVIDASVALFGVVFPHVSYKHRLQMLDHFAECVKQAKGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSALTLVMGALDNPNPILRCAAGEALGRMAQVVGEATFIARMAQYSFDKLKSARDVVSRTGHSLALGCLHRYVGGIGSGQHLKTSVSILLALAQDGTSPEVQTWSLHSLALIVDSSGPMYRGYVEPTLSLVLTLLLTVPPSHTEVHQCLGRCLGAIITTVGPELQGNGATISTIRSSCLVGCAITQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRRAAVACLRQLAQREAAEVCEYAMSLAKNAGDKENSGININTFPPGAGARRDGHSRHQGVNITETGLEGVLFGMLDRETDRKLCSDIHDTLGHMLSSLAVENLSHWLMLCKDVLAASSDMSTAAPLGGGKDEESEKKDEMDDDTMFTTLGEEDKTKPSVAPRWATRVFAADCLCRVIMLCENANKAHFDLALARSARLKNPKNDFLVLHLSDLIRMAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQYQANVGAALRPAFSQDTPSDITAKACQVCSAWIGSGVVSDLNDLRRVHNLLVSSLDKVQAGKGSSSQLYRESATTMEKLAVLKAWAEVYVVAMKIKKEAEAKPKRVLKSTEEDEDDFGTVDELPPDSLITLVQPELPSLSRLWLAALKDYALLTLPAEFATQLPPDGGAFYTPETIDTARLHYRNSWAPILHAVALWLNSTGFSASESTEETAAAMPNSQKRATSIMLNQTPGTPPTTKSLPELNKDRMHLILGVSIQFLCSPRPEEPVEHVTSCLQALHTLLDSPCARIHIAEDQLLGVELLSVLHRLLLTWDPTSVQLLVTGVVQQIVRAAQDYLQEKRNTLNEDDIGEKENPLALGEGGESGGLVPGKSLVFAAMELLMFILVRHMPHLSSKVSDSPSHVAAKSHLSEESARLVAATVTILSDLPSLCSPAGCMTVLPTILFLITRVLKETAVKSADNQVPPPVSAALQGIKTIVTLPTVKTDETQNQWASLIRSTLASVLEYSQPEASKPVLDEVSVLTAITLFLWSASTEIIGVQSLQNGCINRFKNALNSSDPWVQAKCYQLLLSVFQHTNRALSTPYIHSLAPIMVEKLKAVERNRPTNNLELLAVQEGIKVLETLVALGEEQNRVQLLALLVPTLISYLLNENAFASASTASKDLHEFALQNLMHIGPLYPHAFKTVMGAAPELKTRLETAVRASQASKAKAAARQPPPTVHSTPTIKLKTSFF", "length": 2073 }, "evidence": [ { "id": "E1BB26", "url": "https://omabrowser.org/oma/group/E1BB26/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F4HRS2-1", "protein_name": "Protein SWEETIE", "gene_name": "SWEETIE", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MTKNIASDNVPLSRFGVLVAQLESIVASASQKNPDPLLCFEILSDLISAIDEEPKESLLVTQRKCEDALYSLVTLGARRPVRHLASVAMAKIISNGDSISIYSRASSLQGFLSDGKRSDPQRVAGAAQCLGELYRHFGKKITSGLFETTSIVTKLVKFNEDFVRQEAFILLHNALEGCGGTAAATAYSEAYRLITRFSTLDKSFVVRIAAARCLKAFSNIGGPGLGTSEFDTLASYCVKGIEDSESSVRDAFAEALGSLLALGMHPEAHVQPRGKGPFPPAKKLEGGLQRHLILPFTKAVGSRAKNTRFGLALSWVFFLQAIRIRYLDSDSELQDYSLPIMDMLRGDSSIDAHALACVLYILRVGVIDQMMEPSQRSFSVFLGKQLQSSNASPSMKIVALRALSYTLKTLGEVPHEFKEFFDDTVGAALSHFLDLVRVEAALTLRALAEVDPTCVGGLTSFAVTTLNALRESLSFEKGDKLKTDLASLHGQAATLAALVSISPGLSLGYPARLPRSVLEVSKKMLTESRRNVTVASSEKEAGWLLLSSLLNSMPKEEFGDQDFDILILWTDVFAGNPEHLIKQQAELKSMLSVWSAAIDALTAFVRRFVSCNDGILLQPVLANLRSALSCVSTMANKRFSDVKTLVDILIIRILIAYQSIPDPLAYKSEHQQIIQLCTTPYRDPSGFEESSCLKSLLDKRDAWLGPWIPGRDWFEDELRYFQGGEDGLAPSVWESKVSSFPLPETVKKTLVNQMVLCFGIMFASQDSQGMLSLLSVIQQCLKAGKKQQWRTASLTNICAGLLAGLKALHALRPQQLTTEVLSSGQAIFQNILTEGDICASQRRAACEGLGLLARLGNDIFTARMTRVLLGDLSGVTDPNYGGSIALALGCIHHSAGGMALSSLVPATVNSVSSLTKTSVLGLKIWALHGLLLTIEAAGLSFVSHVQAALGLALDILLTEESGWIDLSQGIGRLINAIVAVLGPELSPGSILFSRCKSVIAEISSWQEIPTLLESVCFTQQLILFAPQAVSVHIHVKNLLMTLASRQPIIRRLSVSTLRHLVEKDPVSVIDEQIEDNLFQMLDEETDSEIGNLIRSTLIRLLYATCPSRPSRWMLICRNMALAASAGRSAETSIAENDPAYTRENLGDDDEDMVSSSSGKSIRANPDKDKTLRYRTRVFAAECLSLLPEAVGNDAAHFDILLARNLASNRQSSGDWLVLQLQELISLAYQISTIQFENMRPIGVGLLSTILEKFKLVADPELPGHLLLEQYQAQLLSAVRTALDANSGPVLLEAGLQLATKIMTSGIIRSDQVAVKRIFSLLSRPLNDFNELYYPSFAEWVTSKIKIRLLAAHASLKCYIFTFLRKHHGEVPVEFEALLPMFSKSSDLLGRYWIQVLKGYSYICLCQNLKKSQCSFLDEILPHTVSRRLQPCLEEAWPVILQALVLDAIPVNHSVEEFSDRSLISTHRMVTLEAEDFQFLWGFAVLVLFQGMHPASSMQVIPFSSAKIKSSGDSSINESSFQGLKLYEIALPVFQSLSAGRFFSSGFLSIDLCQELLQVLSYSFHMDSSWDILAVSVVQQISQNCPKDFLESEEFAYSTIELCLGYLFKILHRHNEISPDDGIWDNMLSPLFISIKTLVKRFELKHRLNSAPLAFLLSGYKCIRQVPTDAYLPKALEIVKSTNDLLLELTRASSQKPYTDGTNFAADSGFHLRAIFGACLHMVGDLTRDCINGIQLVDSKRSGLRKLLQLKLVFCLEQLFSLAKLAYEFDCPVDETNTNSICIVMLKSCQISIAAVVKDSNVQVQATVLQVLKSLVQRYNNPEEKSFVILFVGELIGDIVSLMQRALLKPVNTESVVIAGECLRFIMLLQTHSITDELQKGFMSLFLEVVLVVFSKTSDGVSQEVLELRNVAVRLVSHLAQLPSSAVHFKDVLLSLPVTHRQQLQDIIRASVSKDSALAKPKSLVPAMDIKLPAPVVATPEKVTSTANMVKEEALSTMPTSFNQVSTVESGTDEEEEEEEDDDDDDWDTFQSFPASTNLEGSESKTESVAEEEPDLPGRSSIQDDESNAEETDDQHLASDHATDITREDSNDKSKEVVEEETVEPCFTTREDSVDKSKEVEEETVKPCLIEDALTSQNDKTSSGDHPVEINEQSVESKNLESENIGTDIKLASTEVESPALDDLEPQQIQKSPEDESSKEHVGADVIVTEETIAENKSDVDYI", "length": 2222 }, "evidence": [ { "id": "E1BB26", "url": "https://omabrowser.org/oma/group/E1BB26/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q8C547-1", "protein_name": "HEAT repeat-containing protein 5B", "gene_name": "Heatr5b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELAHSLLLNEEALAQITEAKRPVFIFEWLRFLDKVLVAANKTDVKEKQKKLVEQLTGLISSSPGPPTRKLLAKNLAALYSIGDTYTVFQTLDKCNDIIRSKDDTAAYLPTKLAAVACVGAFYEKMGRMLGSAFPETVNNLLKSLKSAESQGRSEILMSLQKVLTGLGGAAASSHRDIYKNARSLLTDRSMAVRCAVAKCLLELQNEAVFMWTAELENVATLCFKALENSNYGVRVAVSKLLGTVMATALMPKQATVMRQNVKRATFDEVLELMATGFLRGGSGFLKSGGEMLKVGGSVNREVRVGVTQAYVVFVTTLGGQWLERSFATFLSHVLDLVSHPRATQTHVDAVYSRRCVSFMLRATVGSLLGEKAQIAAAKEICQAIGKQMKAVEAVVNDTSSENKSGTADIAASQHVMVCALQELGSLVQSLNATASPLIQEASIGLLEIVTSVLLHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNNLKTSPEAVSGYSFAMAALLGGVHQCPLGIPHAKGKMVVSIAEDLLRTAAQNSRLSLQRTQAGWLLLGALMTLGPSVVRYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFVAHCPELLTEDAIRKLMTPIECAMTMMSHIPSVIKAHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEFTLTDNSANTTTSLLRSLCHYDDSVLLGSWLQETDHKSIEDQLQPNSASGSGALEHDPSSIYLRIPAGEAVPGPLPLGVSVIDASVALFGVVFPHVSYKHRLQMLDHFAECVKQAKGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSALTLVMGALDNPNPILRCAAGEALGRMAQVVGEASFIARMAQYSFDKLKSARDVVSRTGHSLALGCLHRYVGGIGSGQHLKTSVSILLALAQDGTSPEVQTWSLHSLALIVDSSGPMYRGYVEPTLSLVLTLLLTVPPSHTEVHQCLGRCLGAIITTVGPELQGNAATISTIRSSCLVGCAITQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRRAAVACLRQLAQREAAEVCEYAMSLAKNAGDKEISGGNVNPFTPGVSSRSDVHCRHQGVNITDTGLEGLLFGMLDRETDRKLCSDIHDTLGHMLSSLAVEKLSHWLMLCKDVLAASSDMSAATLLSSGKDEESEKKDEMDDDAMFTTLGEEDKSKPFVAPRWATRVFAADCLCRIINLCENSDQAHFDLALARSAKLRNPKNDLLVLHLSDLIRMAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQYQANVGAALRPAFSQDTPSDIIAKACQVCSTWIGSGVVSDLNDLRRVHNLLVSSLDTVQAGKGSSSQLYRESATTMEKLAVLKAWAEVYVVAMNIKKEAESKPKRAMNNPDDDDDDYGTIDELPPDSLITLVQPELPTLSRLWLAALKDYALLTLPAEFSSQLPPDGGAFYTPETIDTARLHYRNSWAPILHAVALWLNSTGFISQESTEATTVSGVQKRSPAVSLNQVPGAMASAKPLPEVNKDRMHLILGVSIQFLCSPRPEEPIEHVTACLQALHTLLGSPYARIHIAEDQLIGVELLSVLHRLLLTWNPPSIQLLVTGVVQQIVRAAQDYLQEKRNALNEEDMEKESCPTLGEGGDTGGLIPGKSLVFATMELLMFILVRHMPHLSTKMLDSPSHTAMKTQLSEESARLVAATVAILSDLPSLCSPAGCMTILPTILFLIARILKDTAIKSADNQVPPPVSAALQGIKSIVTLSMAKTEDTQKQWTTLIRSTLACILEYSQPDDCMPAPDEVSTLTAIALFLWSASSEIIGVQSLQNGCMNRFKSALNSCDPWVQAKCYQLLLSVFQHSNRALSTPYIHSLAPLVVGKLKAVERHRPASSTELLAVQEGIKVLETLVALGEEQNRVQLLALLVPTLISYLLDENSFASASSISKDLHEFALQNLMHIGPLYPHAFKTVMGAAPELKARLETAVRASQASKAKAAARQPAPTTHSTPTIKLKTSFF", "length": 2070 }, "evidence": [ { "id": "E1BB26", "url": "https://omabrowser.org/oma/group/E1BB26/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P2D3-1", "protein_name": "HEAT repeat-containing protein 5B", "gene_name": "HEATR5B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELAHSLLLNEEALAQITEAKRPVFIFEWLRFLDKVLVAANKTDVKEKQKKLVEQLTGLISSSPGPPTRKLLAKNLAALYSIGDTFTVFQTLDKCNDIIRNKDDTAAYLPTKLAAVACVGAFYEKMGRMLGSAFPETVNNLLKSLKSAESQGRSEILMSLQKVLSGLGGAAASSHRDIYKNARSLLTDRSMAVRCAVAKCLLELQNEAVFMWTAELENIATLCFKALENSNYGVRVAVSKLLGTVMATALMPKQATVMRQNVKRATFDEVLELMATGFLRGGSGFLKSGGEMLKVGGSVNREVRVGVTQAYVVFVTTLGGQWLERSFATFLSHVLDLVSHPRATQTHVEAVYSRRCVSFILRATVGSLLGEKAQIAAAKEICQAIGKQMKAVEAVVNDTSGENKSGAADIAASQHVMVCALQELGSLVQSLNATASPLIQEASIGLLEIVTSVLLHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNNLKTSPEAVSGYSFAMAALLGGVHQCPLGIPHAKGKMVVSIAEDLLRTAAQNSRLSLQRTQAGWLLLGALMTLGPSVVRYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFVAHCPELLTEDVIRKLMTPIECAMTMMSHIPSVMKAHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEFTLTDNSANTTTSLLRSLCHYDDSVLLGSWLQETDHKSIEDQLQPNSASGSGALEHDPSSIYLRIPAGEAVPGPLPLGVSVIDASVALFGVVFPHVSYKHRLQMLDHFAECVKQAKGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSALTLVMGPLDNPNPILRCAAGEALGRMAQVVGEATFIARMAQYSFDKLKSARDVVSRTGHSLALGCLHRYVGGIGSGQHLKTSVSILLALAQDGTSPEVQTWSLHSLALIVDSSGPMYRGYVEPTLSLVLTLLLTVPPSHTEVHQCLGRCLGAIITTVGPELQGNGATTSTIRSSCLVGCAITQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRRAAVACLRQLAQREAAEVCEYAMSLAKNTGDKESSSANVSPFAPGVSSRTDIHCRHQGVNITETGLEGLLFGMLDRETDRKLCSDIHDTLGHMLSSLAVEKLSHWLMLCKDVLAASSDMSTATLLSSGKDEEAEKKDEMDDDTMFTTLGEEDKSKPFVAPRWATRVFAADCLCRIINLCENADQAHFDLALARSAKLRNPTNDLLVLHLSDLIRMAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQYQANVGAALRPAFSQDTPSDIIAKACQVCSTWIGSGVVSDLNDLRRVHNLLVSSLDKVQAGKGSSSQLYRESATTMEKLAVLKAWAEVYVVAMNIKKEAESKPKRAIKNTDDDDDDCGTIDELPPDSLITLVQPELPTLSRLWLAALKDYALLTLPAEFSSQLPPDGGAFYTPETIDTARLHYRNSWAPILHAVALWLNSTGFTCSESTEAAAISGLQKRSTSVNLNQASGAVGSAKSLPEINKDRMHLILGVSIQFLCSPRPEEPIEHVTACLQALHTLLDSPYARVHIAEDQLIGVELLSVLHRLLLTWNPSSVQLLVTGVVQQIVRAAQDYLQEKRNTLNEDDMEKEACTVLGEGGDSGGLIPGKSLVFATMELLMFILVRHMPHLSTKVSDSPSHIATKTRLSEESARLVAATVTILSDLPSLCSPAGCMTILPTILFLIARILKDTAIKSADNQVPPPVSAALQGIKSIVTLSMAKTEAGVQKQWTALIRSTLACILEYSQPEDSVPTPDEVSMLTAIALFLWSASNEIIGVQSLQNGCMNRFKNALNSCDPWVQAKCYQLLLSVFQHSNRALSTPYIHSLAPIVVEKLKAVERNRPASNIELLAVQEGIKVLETLVALGEEQNRVQLLALLVPTLISYLLDENSFASASSASKDLHEFALQNLMHIGPLYPHAFKTVMGAAPELKVRLETAVRASQASKAKAAARQPAPAIHSAPTIKLKTSFF", "length": 2071 }, "evidence": [ { "id": "E1BB26", "url": "https://omabrowser.org/oma/group/E1BB26/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "E1BB26", "url": "https://www.uniprot.org/uniprotkb/E1BB26" } ], "pmid": "" }, { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "E1BB26", "url": "https://www.uniprot.org/uniprotkb/E1BB26" } ], "pmid": "" }, { "name": "intracellular protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "E1BB26", "url": "https://www.uniprot.org/uniprotkb/E1BB26" } ], "pmid": "" }, { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "E1BB26", "url": "https://www.uniprot.org/uniprotkb/E1BB26" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "clathrin-coated vesicle", "id": "GO:0030136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030136", "evidence": [ { "database": "UniProtKB", "id": "E1BB26", "url": "https://www.uniprot.org/uniprotkb/E1BB26" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "E1BB26", "url": "https://www.uniprot.org/uniprotkb/E1BB26" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BB26", "url": "https://www.uniprot.org/uniprotkb/E1BB26" } ], "pmid": "" }, { "name": "endocytic vesicle", "id": "GO:0030139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030139", "evidence": [ { "database": "UniProtKB", "id": "E1BB26", "url": "https://www.uniprot.org/uniprotkb/E1BB26" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1063, "end_pos": 1065, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1121, "end_pos": 1123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1143, "end_pos": 1145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1540, "end_pos": 1542, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1566, "end_pos": 1568, "annotation": "n_glycosylation_sequon" }, { "start_pos": 397, "end_pos": 399, "annotation": "n_glycosylation_sequon" }, { "start_pos": 403, "end_pos": 405, "annotation": "n_glycosylation_sequon" }, { "start_pos": 41, "end_pos": 43, "annotation": "n_glycosylation_sequon" }, { "start_pos": 432, "end_pos": 434, "annotation": "n_glycosylation_sequon" }, { "start_pos": 708, "end_pos": 710, "annotation": "n_glycosylation_sequon" }, { "start_pos": 840, "end_pos": 842, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1063, "end_pos": 1065 }, { "start_pos": 1121, "end_pos": 1123 }, { "start_pos": 1143, "end_pos": 1145 }, { "start_pos": 1540, "end_pos": 1542 }, { "start_pos": 1566, "end_pos": 1568 }, { "start_pos": 397, "end_pos": 399 }, { "start_pos": 403, "end_pos": 405 }, { "start_pos": 41, "end_pos": 43 }, { "start_pos": 432, "end_pos": 434 }, { "start_pos": 708, "end_pos": 710 }, { "start_pos": 840, "end_pos": 842 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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"count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B913-1", "uniprot_ac": "E1B913", "uniprot_id": "E1B913_BOVIN", "mass": { "chemical_mass": 54507.0, "monoisotopic_mass": 54507.0 }, "refseq": { "ac": "NP_001179773", "name": "threonine synthase-like 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179773" }, "gene_names": [ { "name": "THNSL2", "type": "recommended", "evidence": [ { "id": "E1B913", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B913" } ] }, { "name": "THNSL2", "type": "synonym", "evidence": [ { "id": "NP_001179773", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179773" } ] } ], "protein_names": [ { "name": "Threonine synthase-like 2", "type": "recommended", "evidence": [ { "id": "E1B913", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B913/entry#names_and_taxonomy" } ] }, { "name": "threonine synthase-like 2", "type": "synonym", "evidence": [ { "id": "NP_001179773", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179773" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B913", "url": "https://www.uniprot.org/uniprotkb/E1B913" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "THNSL2", "url": "https://www.uniprot.org/uniprotkb/E1B913", "locus": { "chromosome": "11", "start_pos": 47866198, "end_pos": 47884150, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004364", "url": "https://www.ensembl.org/id/ENSBTAG00000004364" } ] } } ], "crossref": [ { "id": "E1B913", "url": "https://alphafold.ebi.ac.uk/entry/E1B913", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004364", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004364", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01560", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01560", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "541205", "url": "https://www.ncbi.nlm.nih.gov/gene/541205", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004450", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004450", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036052", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036052", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037158", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037158", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051166", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051166", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541205", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541205", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NFERYLY", "url": "https://omabrowser.org/oma/group/NFERYLY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B913", "url": "https://www.orthodb.org/?gene=E1B913", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42690", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42690", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42690:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42690:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00291", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00291", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14821", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14821", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24857", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24857", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179773", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M452", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M452", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M452-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M452-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0R8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0R8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0R8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0R8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAX8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B913", "url": "https://www.uniprot.org/uniprotkb/E1B913", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B913-1", "url": "https://www.uniprot.org/uniprotkb/E1B913-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWYVSTRGMAPRIDFEEALFSGYAPDGGLYMPEELPQLGRETLHEWSTLSYPSLVKELCSLFIGPELIPRDDLNDLIDRAFSRFRHREVVHLSRLRNGLNVLELWHGVTYAFKDLSLCCTAQFLQYFLEKRKRHITVVVGTSGDTGSAAIESVQGAKNVDIIVLLPKGHCTKIQELQMTTVLRENVHVFGVEGNSDELDEPIKTVFADMAFVKKHNLMSLNSINWSRVLVQIAHHFFAYFRCAPSLDMHPLPPVEVVVPTGAAGNLAAGCIAQKMGLPIHLVVAVNSNDIIHRTVQWGDFSLSKAVKPTLASAMDIQVPYNMERIFWLLSSSDSQVIRALMEQFERTKSVSLPKELHSKLLEAVTSQSVSDEAITQTMGRCWQENQYLLCPHSAVAVSCHYQQVDRQQPSPPRCCLAPASAAKFPEAVRAARLTVDTPAEILALEHKEARCTPMRKGDDWTRMLRDTIEDLSQQWQRRFLNLPA", "length": 484, "header": "tr|E1B913-1|E1B913_BOVIN Isoform 1 of Threonine synthase-like 2 OS=Bos taurus OX=9913 GN=THNSL2 PE=3 SV=1 CANONICAL=E1B913-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M452-1", "url": "https://www.uniprot.org/uniprotkb/E1B913/entry#A0A3Q1M452-1", "sequence": { "sequence": "MWYVSTRGMAPRIDFEEALFSGYAPDGGLYMPEELPQLGRETLHEWSTLSYPSLVKELCSLFIGPELIPRDDLNDLIDRAFSRFRHREVVHLSRLRNGLNVLELWHGVTYAFKDLSLCCTAQFLQYFLEKRKRHITVVVGTSGDTGSAAIESVQGAKNVDIIVLLPKGHCTKIQELQMTTVLRENVHVFGVEGNSDELDEPIKTVFADMAFVKKHNLMSLNSINWSRVLVQIAHHFFAYFRCAPSLDMHPLPPVEVVVPTGAAGNLAAGCIAQKMGLPIHLVVAVNSNDIIHRTVQWGDFSLSKAVKPTLASAMDIQVPYNMERIFWLLSSSDSQVIRALMEQFERTKSVSLPKELHSKPSPLLSGSCLCSQVPGGCAGCQADRG", "length": 385, "header": "tr|A0A3Q1M452-1|E1B913_BOVIN Computationally mapped isoform of Threonine synthase-like 2 OS=Bos taurus OX=9913 GN=THNSL2 PE=3 SV=1 CANONICAL=E1B913-1" }, "locus": { "chromosome": "11", "start_pos": 47882428, "end_pos": 47867400, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077401.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077401.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068344.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068344.2" } ] } }, { "isoform_ac": "A0AAA9S0R8-1", "url": "https://www.uniprot.org/uniprotkb/E1B913/entry#A0AAA9S0R8-1", "sequence": { "sequence": "MPLGLVPLQAPGIMWYVSTRGMAPRIDFEEALFSGYAPDGGLYMPEELPQLGRETLHEWSTLSYPSLVKELCSLFIGPELIPRDDLNDLIDRAFSRFRHREVVHLSRLRNGLNVLELWHGVTYAFKDLSLCCTAQFLQYFLEKRKRHITVVVGTSGDTGSAAIESVQGAKNVDIIVLLPKGHCTKIQELQMTTVLRENVHVFGVEGNSDELDEPIKTVFADMAFVKKHNLMSLNSINWSRVLVQIAHHFFAYFRCAPSLDMHPLPPVEVVVPTGAAGNLAAGCIAQKMGLPIHLVVAVNSNDIIHRTVQWGDFSLSKAVKPTLASAMDIQVPYNMERIFWLLSSSDSQVIRALMEQFERTKSVSLPKELHSKLLEAVTSQSVSDEAITQTMGRCWQENQYLLCPHSAVAVSCHYQQVDRQQPSPPRCCLAPASAAKFPEAVRAARLTVDTPAEILALEHKEARCTPMRKGDDWTRMLRDTIEDLSQQWQRRFLNLPA", "length": 497, "header": "tr|A0AAA9S0R8-1|E1B913_BOVIN Computationally mapped isoform of Threonine synthase-like 2 OS=Bos taurus OX=9913 GN=THNSL2 PE=3 SV=1 CANONICAL=E1B913-1" }, "locus": { "chromosome": "11", "start_pos": 47882467, "end_pos": 47867255, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111337.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111337.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077235.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077235.1" } ] } }, { "isoform_ac": "A0AAA9SAX8-1", "url": "https://www.uniprot.org/uniprotkb/E1B913/entry#A0AAA9SAX8-1", "sequence": { "sequence": "LPQLGRETLHEWSTLSYPSLVKELCSLFIGPELIPRDDLNDLIDRAFSRFRHREVVHLSRLRNGLNVLELWHGVTYAFKDLSLCCTAQFLQYFLEKRKRHITVVVGTSGDTGSAAIESVQGAKNVDIIVLLPKGHCTKIQELQMTTVLRENVHVFGVEGNSDELDEPIKTVFADMAFVKKHNLMSLNSINWSRVLVQIAHHFFAYFRCAPSLDMHPLPPVEVVVPTGAAGNLAALPAVVWLLPLQPSSRRLCGLPG", "length": 256, "header": "tr|A0AAA9SAX8-1|E1B913_BOVIN Computationally mapped isoform of Threonine synthase-like 2 OS=Bos taurus OX=9913 GN=THNSL2 PE=3 SV=1 CANONICAL=E1B913-1" }, "locus": { "chromosome": "11", "start_pos": 47882326, "end_pos": 47867410, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103742.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103742.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081058.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081058.1" } ] } }, { "isoform_ac": "E1B913-1", "url": "https://www.uniprot.org/uniprotkb/E1B913/entry#E1B913-1", "sequence": { "sequence": "MWYVSTRGMAPRIDFEEALFSGYAPDGGLYMPEELPQLGRETLHEWSTLSYPSLVKELCSLFIGPELIPRDDLNDLIDRAFSRFRHREVVHLSRLRNGLNVLELWHGVTYAFKDLSLCCTAQFLQYFLEKRKRHITVVVGTSGDTGSAAIESVQGAKNVDIIVLLPKGHCTKIQELQMTTVLRENVHVFGVEGNSDELDEPIKTVFADMAFVKKHNLMSLNSINWSRVLVQIAHHFFAYFRCAPSLDMHPLPPVEVVVPTGAAGNLAAGCIAQKMGLPIHLVVAVNSNDIIHRTVQWGDFSLSKAVKPTLASAMDIQVPYNMERIFWLLSSSDSQVIRALMEQFERTKSVSLPKELHSKLLEAVTSQSVSDEAITQTMGRCWQENQYLLCPHSAVAVSCHYQQVDRQQPSPPRCCLAPASAAKFPEAVRAARLTVDTPAEILALEHKEARCTPMRKGDDWTRMLRDTIEDLSQQWQRRFLNLPA", "length": 484, "header": "tr|E1B913-1|E1B913_BOVIN Isoform 1 of Threonine synthase-like 2 OS=Bos taurus OX=9913 GN=THNSL2 PE=3 SV=1 CANONICAL=E1B913-1" }, "locus": { "chromosome": "11", "start_pos": 47882428, "end_pos": 47867255, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005725.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005725.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005725.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005725.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:541205", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541205", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2QHH3-1", "protein_name": "Threonine synthase-like 2", "gene_name": "Thnsl2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MWYTSTRGMAPRVNFEGALFSGYAPDGGLYVPEELPQLDRETMCRWSTLSYRSLVKELCALFIGLELIPRHDLNDLIDQAFSRFRHRDVVHLSRLRNGLNILELWHGVTYAFKDLSLSCTAQFLQYFLQKRKKHVTIVVGTSGDTGSAAIESVQGLKNIDIIVLLPKGRCTKIQELQMTTVLKENVHVFGVEGNSDELDEPIKAVFADVAFVEKHNLMSLNSINWSRVLVQMAHHFFAYFQCAPSLDKHPLPPVEVVVPTGAGGNLAAGCIAQKMGLPICLVVAVNHNDIIHRTVQKGDFSLCEVVKPTLASAMDIQVPYNMERIFWLLSGSDSQATRVLMEQFERSQSLHLPKELHSKLSQAMTSESVSDETITQTMGRCWEENQYLLCPHSATAVNYHYQQTDRGQSSISRCCLAPASAAKFPEAVQAAGLTPQTPAEILALEHKETRCLPMRRGDDWTQMLKDTIEGLSQRWKGCAVNPSE", "length": 484 }, "evidence": [ { "id": "E1B913", "url": "https://omabrowser.org/oma/group/E1B913/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P16120-1", "protein_name": "Threonine synthase", "gene_name": "THR4", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MPNASQVYRSTRSSSPKTISFEEAIIQGLATDGGLFIPPTIPQVDQATLFNDWSKLSFQDLAFAIMRLYIAQEEIPDADLKDLIKRSYSTFRSDEVTPLVQNVTGDKENLHILELFHGPTYAFKDVALQFVGNLFEYFLQRTNANLPEGEKKQITVVGATSGDTGSAAIYGLRGKKDVSVFILYPTGRISPIQEEQMTTVPDENVQTLSVTGTFDNCQDIVKAIFGDKEFNSKHNVGAVNSINWARILAQMTYYFYSFFQATNGKDSKKVKFVVPSGNFGDILAGYFAKKMGLPIEKLAIATNENDILDRFLKSGLYERSDKVAATLSPAMDILISSNFERLLWYLAREYLANGDDLKAGEIVNNWFQELKTNGKFQVDKSIIEGASKDFTSERVSNEETSETIKKIYESSVNPKHYILDPHTAVGVCATERLIAKDNDKSIQYISLSTAHPAKFADAVNNALSGFSNYSFEKDVLPEELKKLSTLKKKLKFIERADVELVKNAIEEELAKMKL", "length": 514 }, "evidence": [ { "id": "E1B913", "url": "https://omabrowser.org/oma/group/E1B913/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q5M7T9-1", "protein_name": "Threonine synthase-like 2", "gene_name": "Thnsl2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWYTSTRGMAPRVNFEGALFSGYAPDGGLYMPEELPRLDKETLRHWSTLSYRSLVKELCALFVGLELIPRHDLNGLIDQAFSRFRHRDVVHLCKLKNGLNILELWHGVTYAFKDLSLSCTAQFLQYFLEKKKKHVTIVVGTSGDTGSAAIESVQGSKNVDIIVLLPKGHCSKIQELQMTTVVKENVHVFGVEGNSDELDEPIKAVFADVAFVQRHNLMSLNSINWSRVLVQMAHHFFAYFQCTPSLDMHLLPTVEVVVPTGAGGNLAAGCIAQKMGLPISLVVAVNRNDIIHRTVQKGDFSLCEVVRKTLASAMDIQVPYNMERIFWLLAGSDSQTTRALMEQFERTQSLHLPKDLHSKLSEAVTSESVSDEAITQTMGRCWEENQYLLCPHSATAVSYHYQQTDSGQPSSIPRCCLAPASAVKFPEAVQAAGLTPETPAEILALEHKETRCTPMRRGDDWTQMLRDTIEALSLRWKGCVENTAE", "length": 485 }, "evidence": [ { "id": "E1B913", "url": "https://omabrowser.org/oma/group/E1B913/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80W22-1", "protein_name": "Threonine synthase-like 2", "gene_name": "Thnsl2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWYTSTRGMAPRVNFEGALFSGYAPDGGLYMPEELPRLDEETLRHWSTLSYRSLVKELCALFIGLELIPRHDLNDLIDRAFSRFRHRNVVHLCKLKNGLNILELWHGVTYAFKDLSLSCTAQFLQYFLEKKKKHVTIVVGTSGDTGSAAIESVQGSKNVDIIVLLPKGHCSKIQELQMTTVLKENVHVFEVEGNSDELDEPIKAVFADVAFVQRHNVMSLNSINWSRVLVQMAHHFFAYFQCTPSLDTHPLPTVEVVVPTGAGGNLAAGCIAQKMGLPICLVVAVNRNDIIHRTVQKGDFSLCEVLRTTLASAMDIQVPYNMERIFWLLSGSDSQTTRALMEQFERTQSLQLPKDLHNKLSEAVTSESVTDEAITQTMARCWEENQYLLCPHSATAVNYHYQQTDSGQSSIRCCLASASAVKFPEAVQAAGLTPETPAEILALEHKETRCIPMRRGDDWTQMLRVTIEGLSQRWKDCVVNPSE", "length": 483 }, "evidence": [ { "id": "E1B913", "url": "https://omabrowser.org/oma/group/E1B913/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86YJ6-1", "protein_name": "Threonine synthase-like 2", "gene_name": "THNSL2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWYVSTRGVAPRVNFEGALFSGYAPDGGLFMPEELPQLDRGTLCQWSTLSYPGLVKELCALFIGSELLPKDELNDLIDRAFSRFRHREVVHLSRLRNGLNVLELWHGVTYAFKDLSLSCTTQFLQYFLEKREKHVTVVVGTSGDTGSAAIESVQGAKNMDIIVLLPKGHCTKIQELQMTTVLKQNVHVFGVEGNSDELDEPIKTVFADVAFVKKHNLMSLNSINWSRVLVQMAHHFFAYFQCTPSLDTHPLPLVEVVVPTGAAGNLAAGYIAQKIGLPIRLVVAVNRNDIIHRTVQQGDFSLSEAVKSTLASAMDIQVPYNMERVFWLLSGSDSQVTRALMEQFERTQSVNLPKELHSKLSEAVTSVSVSDEAITQTMGRCWDENQYLLCPHSAVAVNYHYQQIDRQQPSTPRCCLAPASAAKFPEAVLAAGLTPETPAEIVALEHKETRCTLMRRGDNWMLMLRDTIEDLSRQWRSHALNTSQ", "length": 484 }, "evidence": [ { "id": "E1B913", "url": "https://omabrowser.org/oma/group/E1B913/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "lyase activity", "id": "GO:0016829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016829", "evidence": [ { "database": "UniProtKB", "id": "E1B913", "url": "https://www.uniprot.org/uniprotkb/E1B913" } ], "pmid": "" }, { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "E1B913", "url": "https://www.uniprot.org/uniprotkb/E1B913" } ], "pmid": "" }, { "name": "phosphatase activity", "id": "GO:0016791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016791", "evidence": [ { "database": "UniProtKB", "id": "E1B913", "url": "https://www.uniprot.org/uniprotkb/E1B913" } ], "pmid": "" }, { "name": "serine binding", "id": "GO:0070905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070905", "evidence": [ { "database": "UniProtKB", "id": "E1B913", "url": "https://www.uniprot.org/uniprotkb/E1B913" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 224, "end_pos": 226, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B913-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 484, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B913-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B913" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B913", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B913" }, { "id": "PF14821", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14821" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Threonine synthase N-terminal", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 81, "start_aa": "Tyr", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B913", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B913" }, { "id": "PF00291", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00291" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tryptophan synthase beta chain-like PALP", "eco_id": "ECO_0000259", "start_pos": 106, "end_pos": 330, "start_aa": "His", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 224, "end_pos": 226 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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"total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B8Z0-1", "uniprot_ac": "E1B8Z0", "uniprot_id": "E1B8Z0_BOVIN", "mass": { "chemical_mass": 135900.0, "monoisotopic_mass": 135900.0 }, "refseq": { "ac": "NP_001192556", "name": "bromodomain and PHD finger-containing protein 3", "summary": "", 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9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8Z0", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BRPF3", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0", "locus": { "chromosome": "23", "start_pos": 10154265, "end_pos": 10118562, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013316", "url": "https://www.ensembl.org/id/ENSBTAG00000013316" } ] } } ], "crossref": [ { "id": "E1B8Z0", "url": "https://alphafold.ebi.ac.uk/entry/E1B8Z0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013316", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013316", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05512", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05512", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15572", "url": 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"Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019542", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019542", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034732", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034732", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507996", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507996", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "XRSLLMP", "url": "https://omabrowser.org/oma/group/XRSLLMP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8Z0", "url": "https://www.orthodb.org/?gene=E1B8Z0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13793", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13793", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13793:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13793:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00439", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00439", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10513", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10513", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13831", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13831", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13832", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13832", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-114608", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3214847", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214847", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6804758", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804758", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192556", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4U1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4U1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4U1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4U1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ56-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSX0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFG5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8Z0", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8Z0-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRKPRRKSRPNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGSSFHLPQPSFRMVDSGSQPEAPPLPAAYYRYIEKSPEDLDAEVEYDMDEEDLAWLDLVNEKRRVDGYSLVSADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCVLCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPGSLSEAGDEEGLKEACEEEEEKEEVEEEEEGEGQGGVGGPLKGMSKKNKMTLKQRIKKEPEEVGRDMTSTVPMVTVPRIPSYRLNKICSGLSFQRKTQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQIKIQQAAMELELMPFNVLLRTTLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYHTLEEFEEDFNLIVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPETGTHLPESPKSEDFYRFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSTMRSSGARTRRVRLLRREINAVRQKLAQPPPPQPPSLNKTVSSGELPAGPRGDVAVLEQAPQEEPEDNGDRDDSKMPPPPTLEPTGPAPSLSEQESPPDPPTLKPINDSKPPSRLLKPRKAEEDELLEKSPLQLGSEPLQRLLSDNGINRVSLMAPDTSPTGAPLSGVGRRTSVLFKKARNGVKLQRSPDRALENGEDHGTADSPVSPASIEDERHSRKRPRSRSCSQSEGERSPQQEEETGVTNGFGKHTESGSDSECSLGLGSGLAFEACSGRTPPKRSRGKPALSRVPFLEGVNGDSDYNSSGRSLLMPFEDRGDLEPLELVWAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFDNKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFVTSSYL", "length": 1207, "header": "tr|E1B8Z0-1|E1B8Z0_BOVIN Isoform 1 of Bromodomain and PHD finger containing 3 OS=Bos taurus OX=9913 GN=BRPF3 PE=4 SV=3 CANONICAL=E1B8Z0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M4U1-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0/entry#A0A3Q1M4U1-1", "sequence": { "sequence": "MRKPRRKSRPNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGSSFHLPQPSFRMVDSGSQPEAPPLPAAYYRYIEKSPEDLDAEVEYDMDEEDLAWLDLVNEKRRVDGYSLVSADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCVLCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPGSLSEAGDEEGLKEACEEEEEKEEVEEEEEGEGQGGVGGPLKGMSKKNKMTLKQRIKKEPEEVGRDMTSTVPMVTVPRIPSYRLNKICSGLSFQRKTQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQDEKTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQIKIQQAAMELELMPFNVLLRTTLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYHTLEEFEEDFNLIVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPETGTHLPESPKSEDFYRFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSTMRSSGARTRRVRLLRREINAVRQKLAQPPPPQPPSLNKTVSSGELPAGPRGDVAVLEQAPQEEPEDNGDRDDSKMPPPPTLEPTGPAPSLSEQESPPDPPTLKPINDSKPPSRLLKPRKAEEDELLEKSPLQLGSEPLQRLLSDNGINRVSLMAPDTSPTGAPLSGVGRRTSVLFKKARNGVKLQRSPDRALENGEDHGTADSPVSPASIEDERHSRKRPRSRSCSQSEGERSPQQEEETGVTNGFGKHTESGSDSECSLGLGSGLAFEACSGRTPPKRSRGKPALSRVPFLEGVNGDSDYNSSGRSLLMPFEDRGDLEPLELVWAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFDNKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFVTSSYL", "length": 1204, "header": "tr|A0A3Q1M4U1-1|E1B8Z0_BOVIN Computationally mapped isoform of Bromodomain and PHD finger containing 3 OS=Bos taurus OX=9913 GN=BRPF3 PE=4 SV=1 CANONICAL=E1B8Z0-1" }, "locus": { "chromosome": "23", "start_pos": 10152152, "end_pos": 10121845, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079099.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079099.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068627.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068627.2" } ] } }, { "isoform_ac": "A0AAA9SQ56-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0/entry#A0AAA9SQ56-1", "sequence": { "sequence": "MRKPRRKSRPNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGSSFHLPQPSFRMVDSGSQPEAPPLPAAYYRYIEKSPEDLDAEVEYDMDEEDLAWLDLVNEKRRVDGYSLVSADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCVLCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPGSLSEAGDEEGLKEACEEEEEKEEVEEEEEGEGQGGVGGPLKGMSKKNKMTLKQRIKKEPEEVGRDMTSTVPMVTVPRIPSYRLNKICSGLSFQRKTQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQIKIQQAAMELELMPFNVLLRTTLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYHTLEEFEEDFNLIVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPETGTHLPESPKSEDFYRFSWEDGRSLLMPFEDRGDLEPLELVWAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFDNKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFVTSSYL", "length": 872, "header": "tr|A0AAA9SQ56-1|E1B8Z0_BOVIN Computationally mapped isoform of Bromodomain and PHD finger containing 3 OS=Bos taurus OX=9913 GN=BRPF3 PE=4 SV=1 CANONICAL=E1B8Z0-1" }, "locus": { "chromosome": "23", "start_pos": 10152152, "end_pos": 10121845, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087869.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087869.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085064.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085064.1" } ] } }, { "isoform_ac": "A0AAA9SSX0-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0/entry#A0AAA9SSX0-1", "sequence": { "sequence": "MRKPRRKSRPNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGSSFHLPQPSFRMVDSGSQPEAPPLPAAYYRYIEKSPEDLDAEVEYDMDEEDLAWLDLVNEKRRVDGYSLVSADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCVLCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPGSLSEAGDEEGLKEACEEEEEKEEVEEEEEGEGQGGVGGPLKGMSKKNKMTLKQRIKKEPEEVGRDMTSTVPMVTVPRIPSYRLNKICSGLSFQRKTQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQIKIQQAAMELELMPFNVLLRTTLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYHTLEEFEEDFNLIVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPETGTHLPESPKSEDFYRFSWEDGVTNGFGKHTESGSDSECSLGLGSGLAFEACSGRTPPKRSRGKPALSRVPFLEGVNGDSDYNSSGRSLLMPFEDRGDLEPLELVWAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFDNKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFVTSSYL", "length": 936, "header": "tr|A0AAA9SSX0-1|E1B8Z0_BOVIN Computationally mapped isoform of Bromodomain and PHD finger containing 3 OS=Bos taurus OX=9913 GN=BRPF3 PE=4 SV=1 CANONICAL=E1B8Z0-1" }, "locus": { "chromosome": "23", "start_pos": 10152152, "end_pos": 10121845, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104521.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104521.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087087.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087087.1" } ] } }, { "isoform_ac": "A0AAA9TFG5-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0/entry#A0AAA9TFG5-1", "sequence": { "sequence": "MRKPRRKSRPNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGSSFHLPQPSFRMVDSGSQPEAPPLPAAYYRYIEKSPEDLDAEVEYDMDEEDLAWLDLVNEKRRVDGYSLVSADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCVLCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPGSLSEAGDEEGLKEACEEEEEKEEVEEEEEGEGQGGVGGPLKGMSKKNKMTLKQRIKKEPEEVGRDMTSTVPMVTVPRIPSYRLNKICSGLSFQRKTQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQIKIQQAAMELELMPFNVLLRTTLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYHTLEEFEEDFNLIVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPETGTHLPESPKSEDFYRFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSTMRSSGARTRRVRLLRREINAVRQKLAQPPPPQPPSLNKTVSSGELPAGPRGDVAVLEQAPQEEPEDNGDRDDSKMPPPPTLEPTGPAPSLSEQESPPDPPTLKPINDSKPPSRLLKPRKAEEDELLEKSPLQLGSEPLQRLLSDNGINRVSLMAPDTSPTGAPLSGVGRRTSVLFKKARNGVKLQRSPDRALENGEDHGTADSPVSPASIEDERHSRKRPRSRSCSQSEGERSPQQEEETGVTNGFGKHTESGSDSECSLGLGSGLAFEACSGRTPPKRSRGKPALSRVPFLEGVNGDSDYNSSDHRPQDAPGGPPAQWCPHPCSPPGCAEAGRAETGRSWREALPCPLL", "length": 1108, "header": "tr|A0AAA9TFG5-1|E1B8Z0_BOVIN Computationally mapped isoform of Bromodomain and PHD finger containing 3 OS=Bos taurus OX=9913 GN=BRPF3 PE=4 SV=1 CANONICAL=E1B8Z0-1" }, "locus": { "chromosome": "23", "start_pos": 10150655, "end_pos": 10121845, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088447.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088447.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097312.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097312.1" } ] } }, { "isoform_ac": "E1B8Z0-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0/entry#E1B8Z0-1", "sequence": { "sequence": "MRKPRRKSRPNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGSSFHLPQPSFRMVDSGSQPEAPPLPAAYYRYIEKSPEDLDAEVEYDMDEEDLAWLDLVNEKRRVDGYSLVSADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCVLCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPGSLSEAGDEEGLKEACEEEEEKEEVEEEEEGEGQGGVGGPLKGMSKKNKMTLKQRIKKEPEEVGRDMTSTVPMVTVPRIPSYRLNKICSGLSFQRKTQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQIKIQQAAMELELMPFNVLLRTTLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYHTLEEFEEDFNLIVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPETGTHLPESPKSEDFYRFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSTMRSSGARTRRVRLLRREINAVRQKLAQPPPPQPPSLNKTVSSGELPAGPRGDVAVLEQAPQEEPEDNGDRDDSKMPPPPTLEPTGPAPSLSEQESPPDPPTLKPINDSKPPSRLLKPRKAEEDELLEKSPLQLGSEPLQRLLSDNGINRVSLMAPDTSPTGAPLSGVGRRTSVLFKKARNGVKLQRSPDRALENGEDHGTADSPVSPASIEDERHSRKRPRSRSCSQSEGERSPQQEEETGVTNGFGKHTESGSDSECSLGLGSGLAFEACSGRTPPKRSRGKPALSRVPFLEGVNGDSDYNSSGRSLLMPFEDRGDLEPLELVWAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFDNKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFVTSSYL", "length": 1207, "header": "tr|E1B8Z0-1|E1B8Z0_BOVIN Isoform 1 of Bromodomain and PHD finger containing 3 OS=Bos taurus OX=9913 GN=BRPF3 PE=4 SV=3 CANONICAL=E1B8Z0-1" }, "locus": { "chromosome": "23", "start_pos": 10152152, "end_pos": 10121845, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017711.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017711.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017711.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017711.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507996", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507996", "resource": "KEGG Pathway" }, { "id": "R-BTA-114608", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "resource": "Reactome", "description": "Platelet degranulation" }, { "id": "R-BTA-3214847", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214847", "resource": "Reactome", "description": "HATs acetylate histones" }, { "id": "R-BTA-6804758", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804758", "resource": "Reactome", "description": "Regulation of TP53 Activity through Acetylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480XYV1-1", "protein_name": "Bromodomain and PHD finger containing 3", "gene_name": "BRPF3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRKLRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKYASGTSFHLPQPSFRVVDSGSQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHGLVSADTFELLVDRLEKESYLESRSNGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCVLCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPGSLSEGGEEEGLKEGCGEEEEKEEVEEEEEDEGQGGVGGSLKGVSKKNKMTSKQRIKKEPEEVGRDTPSTVPMVTVPQIPSYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKLQQAAMELELMPFNVLLRTTLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNLIVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFYRFSWEDVDNILVPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQKLAQPPPPPPPQPPSLNKTVSNGELPAGPQGDMAVLEQAPQEEPEDDGDRDDSKLPPPPTLEPTGPAPSLSEQESPPDPPTLKPISDSKPSSRFLKPRKVEEDELLEKSPLQLGSMPLQRLLSDNGINRVSLMAPDTSPAGAPLSGVGRRTSVLFRKAKNGVKLQRSPDGALENGEDHGAVGSPDSPASIEDERHSRKRPRSRSCSESEGERSPQQEEETGVTNGFGKHTESGSDSECSLGLSGGLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLMPFEDRGDLEPLELVWAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFDNKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFVTSSYL", "length": 1210 }, "evidence": [ { "id": "E1B8Z0", "url": "https://omabrowser.org/oma/group/E1B8Z0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6AAK8-1", "protein_name": "Bromodomain and PHD finger containing, 3", "gene_name": "Brpf3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGRGGDARALPWSEGGDEARESAREGAAKRGPPPAPAILFLPGPGSGAAKPRPPRALLLARPEQSSALKGPPLAHGFPLDGQAGRPISARISASLPSSPSPSFAGARFPCEKGSDFASVCGLSSSFPVAMRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDMDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPAKSKKPSSKGKKKESCSKHAPGTSFHLPQPSFRVVDTGSQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDMAWLDMVNEKRRADGHSSVSADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCVLCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDSIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTIFTVRKTAYCEAHSPSVATARRKGDSPRSLSEVGDEDGLKEGGGEEEQEEGEEEGQEGQGGVGSPLKGVSKKSKMTSKQKIKKELEEAGRETPSITVPMVTVPQIPSYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREHDEKTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFTVLLRTTLDLLQEKDPAHIFAEPVSLSEVPDYLEFISKPMDFSTMRRKLESHLYHTLEEFEEDFNLIVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFYRFSWEDVDNILIPENRAHLSPEAQLKELLEKLDLVSAMRSSGARTRRVRMLRREINALRQKLAQPPPPQLLSLTKTVPNGELPAGSRGDAAGLEQTLQEEPEDEGDRDDSQLPAPPTLEPTGPAPSLSEQESPPDPPTLKPISDSKPSGRLPKPRKVDDEELLGDSALQLGSEPLQCLLSDNGADRLPLTNPDSPPGTPLGNVGRRTSVLFKKAKNGVKLQRGPDGTLENGEDAPASPASMEEEHCSRKRPRSQSCSDSEGERSPQQEEETGVTNGFGKHTESGSDSECSLGLSGGLAFEAGSGLTPPKRSRGKPALSRVPFLEGVNGDSDHSGSGRSLLMPFEDRGDLEPLELVWAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLRLGEQKQAEAGERLFLVLFFDNKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGSHSFVTSSYL", "length": 1328 }, "evidence": [ { "id": "E1B8Z0", "url": "https://omabrowser.org/oma/group/E1B8Z0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B2KF05-1", "protein_name": "Bromodomain and PHD finger-containing protein 3", "gene_name": "Brpf3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPAKSKKPSSKGKRKESCSKHASGTSFHLPQPSFRVVDTGSQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDIAWLDMVNEKRRADGHSSVSADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCVLCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTTFTVRKTAYCEAHSPSVAVARRKGDSPRSLSEVGDEDGPKEGGGEEEQEEAEEEGQEGQGGVGSPLKGVSKKGKMSLKQKIKKEPEEAGREAPSITLPMVTVPQIPSYRLNKICSGLSFQRKTQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFTVLLRTTLDLLQEKDSAHIFAEPVSLSEVPDYLEFISKPMDFSTMRRKLESHLYHTLEEFEEDFNLIVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPRLEDFYRFSWEDVDNILIPENRAHLSPEAQLKELLEKLDLVSTMRSSGARTRRVRMLRREINALRQKLAQPPPPQLLSLNKTVPNGELPAGSRGDTAVLEQAQQEEPEEEGDRDDSKLPAPPTLEPTGPAPSLSEQESPPDPPTLKPISDSKPSSRFLKSRKVEDEELLEKSALQLGSEPLQCLLSDNGIDRLSLTNPDSHPDTPLGTVGRRTSVLFKKAKNGVKLQRGPDGTLENGEDHGPEDDPASPASTEDEHYSRKRPRSRSCSDSEGERSPQQEEETGVTNGFGKHTESGSDSECSLGLSGGLAFEAGSGLTPPKRSRGKPALSRVPFLEGVNGDSDHSGSGRSLLMPFEDHGDLEPLELVWAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGERLFLVLFFDNKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGSHAFVTSSYL", "length": 1204 }, "evidence": [ { "id": "E1B8Z0", "url": "https://omabrowser.org/oma/group/E1B8Z0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F6P390-1", "protein_name": "Bromodomain and PHD finger-containing protein 3 isoform X1", "gene_name": "brpf3b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRKPRRRGGLAGAQSDASDTGTAAVEDSQPRSPSPYRLKVSPTRETLTYAQAQKIVEVDLDGRLHRISIFDPLVVITEDEMTAQDIAECNSNKENSEQTSVSTVVSSPRRSVANRGKKKDVKQLSSSQNHCSNSHGQSQTQSSGNSHHGTLPKPTFKEHEFYEPVEAPPRPSAYYRYIDKSSEDPDTDAEYDMDEEDVAWLELVNEKRDSDGQPHISPDTFELLIDRLEKESFLESRSQASSQSVIDEDAFCCVCLDDECLNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCVLCPNRGGAFKQTSDGRWAHVVCAIWIPEVCFANTVFLEPIEGVDNIPPARWKLTCYLCKQKGCGASIQCHKANCYTAFHVTCAQRAGLFMKIDPVRETTVNGTTFSVKKTAFCEAHSPAVNGSDDEETGGRVLGCRANRGRSAYMQTPELKKQKGSNKVDSKQPQKKGKKEEVSKKTTTLLVTVPEIPAQRLNKISKDVIIQKKNQFMQRLHNYWLLKRQSRNGVPLIRRLHSHLQGQRSAEQAEPDEKLNAVREELKYWQKLRHDLERARLLIELIRKREKLKREQVKIHQAVTEHQLTPVLVLLSSTLEQLQEKDTAKIFAQPVNLKEVPDYLEFITHPMDFSTMQSKLEAHKYRSVTDLEADFNLMISNCLLYNAKDTVFYQAAIRLRDLGGAILRHAQRQAQNTGFDLDTGMHLAESPNKNDYYRCTFEDVDTLLDPDNRLHMTTENQLRELLEKLDVVTSMRSSGARTRRVRLLRREINKVRFKQNLKNSHMLNGDLKEDDDEDDEDKEMDADHNLSSSSSDKDDCKSTPPPMLEPTGLALSPPPGDTPQEPPTLRPMTSDPRTSSCPPKRLKLNSERQELDSDPTPMNSCTKLEDAPPEIKLFNGLSSTESPSRPNTGGVGRRTSVLFKKAKNGAKLQRERDNQMQNGNREDGDAARTHNCTATVKTETTAQPKPSTPPPISVPAKQQTRSHSCSPERERTPPRLTLEPALTNGFRKHKDGGSDSECSSSPTLRELISPPKKSRGKPALSKVPFLETVNGDSDYTGTDVLSNGDTPEPEPLDLVWAKSRGYPSYPALIIDPDMPQDGLLHNGVPIPVPPLDVLRLGEQRQEEAGERLFLVLFFDNKRTWQWLSKDKVIPLGVDDTTDKLRIMEGKKTSIRKSVQVAYDRAMKHLSRVRGDHGFVGSNYM", "length": 1222 }, "evidence": [ { "id": "E1B8Z0", "url": "https://omabrowser.org/oma/group/E1B8Z0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3HZT8-1", "protein_name": "Bromodomain and PHD finger-containing protein 3 isoform X1", "gene_name": "Brpf3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRKPRRKSRQSAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPAKSKKSSSKGKKKESCSKHASGTSSHLPQPSFRVVDTGSQPEAPPLPAAYYRYIEKPPEDQDAEVEYDMDEEDLAWLDMVNEKRRADGHSSVSADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCVLCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTIFTVRKTAYCEAHSPSVAPARRKGDSPRSLIEAGDEDGLKEDGREEEEEEAEEEDQEGQGGVGSPHKGVSKKSKMSLKQKIKKEPEEAGRETPSTTAPMVTVPQIPSYRLNKICSGLSFQKKTQFMQRLHNYWLLKRQARNGAPLIRRLHSHSQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVRVQQAAMELELMPFTVLLRTTLDLLQEKDPAHIFAEPVSLSEVPDYLEFISKPMDFSTMRRKLESHLYHTLEEFEEDFNLIVANCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFYRFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRMLRREINALRQKLAQPAPPQLLSLNKTVSNGELAAGPRGDTAVLEQALQEEPEDDGDRDDSKLPAPPTLEPTGPAPSLSEQESPSDPPTLKPISDSKPSSRSLKSRKVEEEELLEKPALQLGSEPLQCLLSDNGVDRLSLINPDSPPGTPLGGVGRRTSVLFKKARNGVKLPRSPDGTLEDGEDSGTVGSPASPASTEDEHCSRKRPRSGSCSDSEGERSPQQEEETGVTNGFGKHTESGSDSECSLGLSGGLAFEAGSGLTPPKRSRGKPALSRVPFLEGVNGDSDHSGSGRSLLMPFEDRGDLEPLELVWAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFDNKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFVASTYL", "length": 1204 }, "evidence": [ { "id": "E1B8Z0", "url": "https://omabrowser.org/oma/group/E1B8Z0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9ULD4-1", "protein_name": "Bromodomain and PHD finger-containing protein 3", "gene_name": "BRPF3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFRMVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVSADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEEEEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIPSYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRTTLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNLIVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFYRFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQKLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEPTGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLSDNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSPASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSGGLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLEPLELVWAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFDNKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFVTSSYL", "length": 1205 }, "evidence": [ { "id": "E1B8Z0", "url": "https://omabrowser.org/oma/group/E1B8Z0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z0", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0" } ], "pmid": "" }, { "name": "MOZ/MORF histone acetyltransferase complex", "id": "GO:0070776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070776", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z0", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z0", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0" } ], "pmid": "" }, { "name": "histone H4K12 acetyltransferase activity", "id": "GO:0043997", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043997", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z0", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0" } ], "pmid": "" }, { "name": "histone H4K5 acetyltransferase activity", "id": "GO:0043995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043995", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z0", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0" } ], "pmid": "" }, { "name": "histone H4K8 acetyltransferase activity", "id": "GO:0043996", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043996", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z0", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0" } ], "pmid": "" }, { "name": "histone H3K14 acetyltransferase activity", "id": "GO:0036408", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036408", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z0", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0" } ], "pmid": "" }, { "name": "histone reader activity", "id": "GO:0140566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140566", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z0", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z0", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z0", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z0", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0" } ], "pmid": "" }, { "name": "positive regulation of DNA replication", "id": "GO:0045740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045740", "evidence": [ { "database": "UniProtKB", "id": "E1B8Z0", "url": "https://www.uniprot.org/uniprotkb/E1B8Z0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1060, "end_pos": 1062, "annotation": "n_glycosylation_sequon" }, { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 620, "end_pos": 622, "annotation": "n_glycosylation_sequon" }, { "start_pos": 795, "end_pos": 797, "annotation": "n_glycosylation_sequon" }, { "start_pos": 864, "end_pos": 866, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8Z0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1207, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8Z0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8Z0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1060, "end_pos": 1062 }, { "start_pos": 371, "end_pos": 373 }, { "start_pos": 620, "end_pos": 622 }, { "start_pos": 795, "end_pos": 797 }, { "start_pos": 864, "end_pos": 866 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"uniprot_ac": "E1B912", "uniprot_id": "E1B912_BOVIN", "mass": { "chemical_mass": 84848.0, "monoisotopic_mass": 84848.0 }, "refseq": {}, "gene_names": [ { "name": "ZBTB24", "type": "recommended", "evidence": [ { "id": "E1B912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B912" } ] } ], "protein_names": [ { "name": "Zinc finger and BTB domain-containing protein 24", "type": "recommended", "evidence": [ { "id": "E1B912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B912/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein 450", "type": "synonym", "evidence": [ { "id": "E1B912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B912/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in BMP2-induced transcription.", "evidence": [ { "database": "UniProtKB", "id": "E1B912", "url": "https://www.uniprot.org/uniprotkb/E1B912#function" }, { "database": "UniProtKB", "id": "ARBA00056876", "url": "https://www.uniprot.org/uniprotkb/ARBA00056876#function" } ] }, { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M518", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M518#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B912", "url": "https://www.uniprot.org/uniprotkb/E1B912" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZBTB24", "url": "https://www.uniprot.org/uniprotkb/E1B912", "locus": { "chromosome": "9", "start_pos": 40690450, "end_pos": 40680718, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010113", "url": "https://www.ensembl.org/id/ENSBTAG00000010113" } ] } } ], "crossref": [ { "id": "E1B912", "url": "https://alphafold.ebi.ac.uk/entry/E1B912", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010113", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010113", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18212", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18212", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050457", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050457", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M518", "url": "https://www.orthodb.org/?gene=A0A3Q1M518", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B912", "url": "https://www.orthodb.org/?gene=E1B912", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24394:SF59", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24394:SF59", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46105", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46105:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M518", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M518", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M518-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M518-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZA0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZA0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLD4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLD4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B912", "url": "https://www.uniprot.org/uniprotkb/E1B912", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B912-1", "url": "https://www.uniprot.org/uniprotkb/E1B912-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSATSPLSVGAALVRVSTPLQPAAPRSVPRGPGLESRKQTPRGHVDVGSAPQLDNGLILLELLKKMAETSSEPSGQLVVHSDTHSDTVLASFEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMVADTFGILLEFIYTGCLQASEKSTEQILATAQFLKVYDLVKAYTDFQNNHSSPKPPTLNTAGAPLVVISNKKSDHPKRKRGRPRKVNSLQEGKSELAAEEEIQLRVNNSVQNRQNFVVKEGDSGVLNEQITAKELEESEPTCEPARGEEMPVEKDENCDPKTQDSGQDSQSRCSKRRIRRSVKLKDYKLVGDEDDQGSAKRVCGRRKRPGGPEARCKDCGKVFKYNHFLAIHQRSHTGERPFKCNECGKGFAQKHSLQVHTRMHTGERPYTCTVCSKALTTKHSLLEHMSLHSGQKSFTCDQCGKYFSQKRQLKSHYRVHTGHSLPECNDCHRKFMDVSQLKKHLRTHTGEKPFTCEICGKSFTAKSSLQTHIRIHRGEKPYSCAVCGKSFSDSSAKRRHCILHTGKKPFTCPECNLQFARLDNLKAHLKIHSKEKHASDASSISGNNNGEEVRNILQLQPYQLSTSGEQEIQLLVTDSVHNINFMPGPSQGISIVTAESSQNMTADQTANLTLLTQQPEQLQNLILSAQQEQTEHIQSLNMIESQMEPSQTEPVHVITLSKETLEHLHAHQEQTGELHLASASDPAQHLQLTQEPAPPPATHHVPQPTSLSQEQS", "length": 763, "header": "tr|E1B912-1|E1B912_BOVIN Isoform 1 of Zinc finger and BTB domain-containing protein 24 OS=Bos taurus OX=9913 GN=ZBTB24 PE=3 SV=3 CANONICAL=E1B912-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M518-1", "url": "https://www.uniprot.org/uniprotkb/E1B912/entry#A0A3Q1M518-1", "sequence": { "sequence": "MAETSSEPSGQLVVHSDTHSDTVLASFEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMVADTFGILLEFIYTGCLQASEKSTEQILATAQFLKVYDLVKAYTDFQNNHSSPKPPTLNTAGAPLVVISNKKSDHPKRKRGRPRKVNSLQEGKSELAAEEEIQLRVNNSVQNRQNFVVKEGDSGVLNEQITAKELEESEPTCEPARGEEMPVEKDENCDPKTQDSGQDSQSRCSKRRIRRSVKLKDYKLVGDEDDQGSAKRVCGRRKRPGGPEARCKDCGKVFKYNHFLAIHQRSHTGQKSFTCDQCGKYFSQKRQLKSHYRVHTGHSLPECNDCHRKFMDVSQLKKHLRTHTGEKPFTCEICGKSFTAKSSLQTHIRIHRGEKPYSCAVCGKSFSDSSAKRRHCILHTGKKPFTCPECNLQFARLDNLKAHLKIHSKEKHASDASSISGNNNGEEVRNILQLQPYQLSTSGEQEIQLLVTDSVHNINFMPGPSQGISIVTAESSQNMTADQTANLTLLTQQPEQLQNLILSAQQEQTEHIQSLNMIESQMEPSQTEPVHVITLSKETLEHLHAHQEQTGELHLASASDPAQHLQLTQEPAPPPATHHVPQPTSLSQEQS", "length": 642, "header": "tr|A0A3Q1M518-1|E1B912_BOVIN Computationally mapped isoform of Zinc finger and BTB domain-containing protein 24 OS=Bos taurus OX=9913 GN=ZBTB24 PE=3 SV=1 CANONICAL=E1B912-1" }, "locus": { "chromosome": "9", "start_pos": 40689397, "end_pos": 40681585, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072852.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072852.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065347.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065347.1" } ] } }, { "isoform_ac": "A0AAA9SZA0-1", "url": "https://www.uniprot.org/uniprotkb/E1B912/entry#A0AAA9SZA0-1", "sequence": { "sequence": "MAETSSEPSGQLVVHSDTHSDTVLASFEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMVADTFGILLEFIYTGCLQASEKSTEQILATAQFLKVYDLVKAYTDFQNNHSSPKPPTLNTAGAPLVVISNKKSDHPKRKRGRPRKVNSLQEGKSELAAEEEIQLRVNNSVQNRQNFVVKEGDSGVLNEQITAKELEESEPTCEPARGEEMPVEKDENCDPKTQDSGQDSQSRCSKRRIRRSVKLKDYKLVGDEDDQGSAKRVCGRRKRPGGPEARCKDCGKVFKYNHFLAIHQRSHTGEKPFTCEICGKSFTAKSSLQTHIRIHRGEKPYSCAVCGKSFSDSSAKRRHCILHTGKKPFTCPECNLQFARLDNLKAHLKIHSKEKHASDASSISGNNNGEEVRNILQLQPYQLSTSGEQEIQLLVTDSVHNINFMPGPSQGISIVTAESSQNMTADQTANLTLLTQQPEQLQNLILSAQQEQTEHIQSLNMIESQMEPSQTEPVHVITLSKETLEHLHAHQEQTGELHLASASDPAQHLQLTQEPAPPPATHHVPQPTSLSQEQS", "length": 586, "header": "tr|A0AAA9SZA0-1|E1B912_BOVIN Computationally mapped isoform of Zinc finger and BTB domain-containing protein 24 OS=Bos taurus OX=9913 GN=ZBTB24 PE=3 SV=2 CANONICAL=E1B912-1" }, "locus": { "chromosome": "9", "start_pos": 40689397, "end_pos": 40681585, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105773.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105773.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089414.2", "url": "https://www.ensembl.org/id/ENSBTAP00000089414.2" } ] } }, { "isoform_ac": "A0AAF6DLD4-1", "url": "https://www.uniprot.org/uniprotkb/E1B912/entry#A0AAF6DLD4-1", "sequence": { "sequence": "MAETSSEPSGQLVVHSDTHSDTVLASFEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMVADTFGILLEFIYTGCLQASEKSTEQILATAQFLKVYDLVKAYTDFQNNHSSPKPPTLNTAGAPLVVISNKKSDHPKRKRGRPRKVNSLQEGKSELAAEEEIQLRVNNSVQNRQNFVVKEGDSGVLNEQITAKELEESEPTCEPARGEEMPVEKDENCDPKTQDSGQDSQSRCSKRRIRRSVKLKDYKLVGDEDDQGSAKRVCGRRKRPGGPEARCKDCGKVFKYNHFLAIHQRSHTGQKSFTCDQCGKYFSQKRQLKSHYRVHTGHSLPECNDCHRKFMDVSQLKKHLRTHTEEKSHIPVPCVANPSLTRVPRGDTAFYTQAKSLSPALSVTYSLLA", "length": 420, "header": "tr|A0AAF6DLD4-1|E1B912_BOVIN Computationally mapped isoform of Zinc finger and BTB domain-containing protein 24 OS=Bos taurus OX=9913 GN=ZBTB24 PE=3 SV=1 CANONICAL=E1B912-1" }, "locus": { "chromosome": "9", "start_pos": 40688813, "end_pos": 40681585, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064541.4", "url": "https://www.ensembl.org/id/ENSBTAT00000064541.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056205.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056205.3" } ] } }, { "isoform_ac": "E1B912-1", "url": "https://www.uniprot.org/uniprotkb/E1B912/entry#E1B912-1", "sequence": { "sequence": "MSATSPLSVGAALVRVSTPLQPAAPRSVPRGPGLESRKQTPRGHVDVGSAPQLDNGLILLELLKKMAETSSEPSGQLVVHSDTHSDTVLASFEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMVADTFGILLEFIYTGCLQASEKSTEQILATAQFLKVYDLVKAYTDFQNNHSSPKPPTLNTAGAPLVVISNKKSDHPKRKRGRPRKVNSLQEGKSELAAEEEIQLRVNNSVQNRQNFVVKEGDSGVLNEQITAKELEESEPTCEPARGEEMPVEKDENCDPKTQDSGQDSQSRCSKRRIRRSVKLKDYKLVGDEDDQGSAKRVCGRRKRPGGPEARCKDCGKVFKYNHFLAIHQRSHTGERPFKCNECGKGFAQKHSLQVHTRMHTGERPYTCTVCSKALTTKHSLLEHMSLHSGQKSFTCDQCGKYFSQKRQLKSHYRVHTGHSLPECNDCHRKFMDVSQLKKHLRTHTGEKPFTCEICGKSFTAKSSLQTHIRIHRGEKPYSCAVCGKSFSDSSAKRRHCILHTGKKPFTCPECNLQFARLDNLKAHLKIHSKEKHASDASSISGNNNGEEVRNILQLQPYQLSTSGEQEIQLLVTDSVHNINFMPGPSQGISIVTAESSQNMTADQTANLTLLTQQPEQLQNLILSAQQEQTEHIQSLNMIESQMEPSQTEPVHVITLSKETLEHLHAHQEQTGELHLASASDPAQHLQLTQEPAPPPATHHVPQPTSLSQEQS", "length": 763, "header": "tr|E1B912-1|E1B912_BOVIN Isoform 1 of Zinc finger and BTB domain-containing protein 24 OS=Bos taurus OX=9913 GN=ZBTB24 PE=3 SV=3 CANONICAL=E1B912-1" }, "locus": { "chromosome": "9", "start_pos": 40689397, "end_pos": 40680888, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013338.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013338.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013338.6", "url": "https://www.ensembl.org/id/ENSBTAP00000013338.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1B912", "url": "https://www.uniprot.org/uniprotkb/E1B912" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B912", "url": "https://www.uniprot.org/uniprotkb/E1B912" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "E1B912", "url": "https://www.uniprot.org/uniprotkb/E1B912" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1B912", "url": "https://www.uniprot.org/uniprotkb/E1B912" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B912", "url": "https://www.uniprot.org/uniprotkb/E1B912" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1B912", "url": "https://www.uniprot.org/uniprotkb/E1B912" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1B912", "url": "https://www.uniprot.org/uniprotkb/E1B912" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "E1B912", "url": "https://www.uniprot.org/uniprotkb/E1B912" } ], "pmid": "" }, { "name": "regulation of immune system process", "id": "GO:0002682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002682", "evidence": [ { "database": "UniProtKB", "id": "E1B912", "url": "https://www.uniprot.org/uniprotkb/E1B912" } ], "pmid": "" }, { "name": "regulation of cytokine production", "id": "GO:0001817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001817", "evidence": [ { "database": "UniProtKB", "id": "E1B912", "url": "https://www.uniprot.org/uniprotkb/E1B912" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 650, "end_pos": 652, "annotation": "n_glycosylation_sequon" }, { "start_pos": 658, "end_pos": 660, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B912-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 763, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B912-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B912" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B912" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 102, "end_pos": 168, "start_aa": "Cys", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B912" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 361, "end_pos": 388, "start_aa": "Ala", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 196, "end_pos": 198 }, { "start_pos": 254, "end_pos": 256 }, { "start_pos": 650, "end_pos": 652 }, { "start_pos": 658, "end_pos": 660 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BBZ9-1", "uniprot_ac": "E1BBZ9", "uniprot_id": "E1BBZ9_BOVIN", "mass": { "chemical_mass": 47311.0, "monoisotopic_mass": 47311.0 }, "refseq": { "ac": "XP_002695684", "name": "WD repeat and SOCS box-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695684" }, "gene_names": [ { "name": "WSB1", "type": "recommended", "evidence": [ { "id": "E1BBZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBZ9" } ] }, { "name": "WSB1", "type": "synonym", "evidence": [ { "id": "XP_002695684", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695684" } ] } ], "protein_names": [ { "name": "WD repeat and SOCS box-containing protein 1", "type": "recommended", "evidence": [ { "id": "E1BBZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBZ9/entry#names_and_taxonomy" } ] }, { "name": "WD repeat and SOCS box-containing protein 1", "type": "synonym", "evidence": [ { "id": "XP_002695684", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695684" } ] } ], "function": [ { "annotation": "Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ9", "url": "https://www.uniprot.org/uniprotkb/E1BBZ9#function" }, { "database": "UniProtKB", "id": "ARBA00054827", "url": "https://www.uniprot.org/uniprotkb/ARBA00054827#function" }, { "database": "UniProtKB", "id": "A0AAA9TGP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBZ9", "url": "https://www.uniprot.org/uniprotkb/E1BBZ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WSB1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ9", "locus": { "chromosome": "19", "start_pos": 19003962, "end_pos": 18989752, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005008", "url": "https://www.ensembl.org/id/ENSBTAG00000005008" } ] } } ], "crossref": [ { "id": "E1BBZ9", "url": "https://alphafold.ebi.ac.uk/entry/E1BBZ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005008", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005008", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03746", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03746", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614851", "url": "https://www.ncbi.nlm.nih.gov/gene/614851", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614851", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614851", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YVWDPHT", "url": "https://omabrowser.org/oma/group/YVWDPHT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M9V8", "url": "https://www.orthodb.org/?gene=A0A3Q1M9V8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BBZ9", "url": "https://www.orthodb.org/?gene=E1BBZ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15622", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15622", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15622:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15622:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07525", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07525", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002695684", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695684", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9V8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9V8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9V8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9V8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TF44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TF44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF44-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBZ9", "url": "https://www.uniprot.org/uniprotkb/E1BBZ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBZ9-1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASFPPRVNEKEIVRSRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKLVPWSQCLKNFLLHGTKNITNSSSLRLSRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHTGAILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPVPSKVLEFLSYRV", "length": 421, "header": "tr|E1BBZ9-1|E1BBZ9_BOVIN Isoform 1 of WD repeat and SOCS box-containing protein 1 OS=Bos taurus OX=9913 GN=WSB1 PE=4 SV=1 CANONICAL=E1BBZ9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M9V8-1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ9/entry#A0A3Q1M9V8-1", "sequence": { "sequence": "MASFPPRVNEKEIDGSYFAWSQGHRTVKLVPWSQCLKNFLLHGTKNITNSSSLRLSRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVVAAILV", "length": 213, "header": "tr|A0A3Q1M9V8-1|E1BBZ9_BOVIN Computationally mapped isoform of WD repeat and SOCS box-containing protein 1 OS=Bos taurus OX=9913 GN=WSB1 PE=4 SV=2 CANONICAL=E1BBZ9-1" }, "locus": { "chromosome": "19", "start_pos": 18999762, "end_pos": 18989824, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085244.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085244.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067355.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067355.2" } ] } }, { "isoform_ac": "A0AAA9TF44-1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ9/entry#A0AAA9TF44-1", "sequence": { "sequence": "MASFPPRVNEKEIGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVVAAILV", "length": 54, "header": "tr|A0AAA9TF44-1|E1BBZ9_BOVIN Computationally mapped isoform of WD repeat and SOCS box-containing protein 1 OS=Bos taurus OX=9913 GN=WSB1 PE=4 SV=1 CANONICAL=E1BBZ9-1" }, "locus": { "chromosome": "19", "start_pos": 18999762, "end_pos": 18989824, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119184.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119184.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095470.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095470.1" } ] } }, { "isoform_ac": "A0AAA9TGP1-1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ9/entry#A0AAA9TGP1-1", "sequence": { "sequence": "MASFPPRVNEKEIGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHTGAILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPVPSKVLEFLSYRV", "length": 275, "header": "tr|A0AAA9TGP1-1|E1BBZ9_BOVIN Computationally mapped isoform of WD repeat and SOCS box-containing protein 1 OS=Bos taurus OX=9913 GN=WSB1 PE=4 SV=1 CANONICAL=E1BBZ9-1" }, "locus": { "chromosome": "19", "start_pos": 19003387, "end_pos": 18989824, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123123.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123123.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095367.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095367.1" } ] } }, { "isoform_ac": "E1BBZ9-1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ9/entry#E1BBZ9-1", "sequence": { "sequence": "MASFPPRVNEKEIVRSRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKLVPWSQCLKNFLLHGTKNITNSSSLRLSRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHTGAILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPVPSKVLEFLSYRV", "length": 421, "header": "tr|E1BBZ9-1|E1BBZ9_BOVIN Isoform 1 of WD repeat and SOCS box-containing protein 1 OS=Bos taurus OX=9913 GN=WSB1 PE=4 SV=1 CANONICAL=E1BBZ9-1" }, "locus": { "chromosome": "19", "start_pos": 19003387, "end_pos": 18989824, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006593.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006593.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006593.4", "url": "https://www.ensembl.org/id/ENSBTAP00000006593.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 302, "start_aa": "Thr", "end_pos": 302, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr302", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:614851", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614851", "resource": "KEGG Pathway" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZUC3-1", "protein_name": "WD repeat and SOCS box-containing protein 1", "gene_name": "WSB1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASFPPRVNEKEIVRSRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKLVPWSQCLKNFLLHGTKNITNSSSLRLSRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWDMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHTGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKVLEFLSYRI", "length": 421 }, "evidence": [ { "id": "E1BBZ9", "url": "https://omabrowser.org/oma/group/E1BBZ9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O54927-1", "protein_name": "WD repeat and SOCS box-containing protein 1", "gene_name": "Wsb1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASFPPRVNEKEIVRSRTIGELLAPAAPFDKKCGGENWTVAFAPDGSYFAWSQGYRIVKLVPWSQCRKNFLLHGSKNVTNSSCLKLARQNSNGGQKNKPPEHVIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHIEMVRDLTFAPDGSLLLVSASRDKTLRVWDLKDDGNMVKVLRAHQNWVYSCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLMEFGHLFPSPTPIFAGGANDRWVRAVSFSHDGLHVASLADDKMVRFWRIDEDCPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSYRG", "length": 421 }, "evidence": [ { "id": "E1BBZ9", "url": "https://omabrowser.org/oma/group/E1BBZ9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7T2F6-1", "protein_name": "WD repeat and SOCS box-containing protein 1", "gene_name": "wsb1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MASFPDCVNENEIGKAKFIGELIPPVAPFDQKSGRETWTVAFAPDGSYFAWSQGHRIVRLVPWKKCLASFSVRKEDRSSGAGPRRLSRQNSEGSLLPGEPREHTIDCGDIVWGLAFGSSVPEKQSRCVNIEWHRFKFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLMDHTDIVRDLTFAPDGSLVLVSASRDKTLRVWDLKDDGNMVKVLRGHQNWVYCSAFSPDSSVLCSVGAGKAVFLWDMDKYTLIRKLEGHHNDVVCCEFSPDGALLATASYDTRVIVWDPHTATVLLELGHLFPPPSPIFAGGANDRWVRSVAFCHDGRHIASVTDDRLVRFWSIDEKSPQAIGPLTNGLCCAFSTDGSVLSAGSRDGSVHFWASPRSIASLQHLCRMTLRRVMPTQQVYTLPIPFSMQDYLAYKTL", "length": 423 }, "evidence": [ { "id": "E1BBZ9", "url": "https://omabrowser.org/oma/group/E1BBZ9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9Y6I7-1", "protein_name": "WD repeat and SOCS box-containing protein 1", "gene_name": "WSB1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASFPPRVNEKEIVRLRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKLVPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYRI", "length": 421 }, "evidence": [ { "id": "E1BBZ9", "url": "https://omabrowser.org/oma/group/E1BBZ9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ9", "url": "https://www.uniprot.org/uniprotkb/E1BBZ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ9", "url": "https://www.uniprot.org/uniprotkb/E1BBZ9" } ], "pmid": "" }, { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ9", "url": "https://www.uniprot.org/uniprotkb/E1BBZ9" } ], "pmid": "" }, { "name": "protein K27-linked ubiquitination", "id": "GO:0044314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044314", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ9", "url": "https://www.uniprot.org/uniprotkb/E1BBZ9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ9", "url": "https://www.uniprot.org/uniprotkb/E1BBZ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" }, { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBZ9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 421, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBZ9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBZ9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBZ9" }, { "id": "PS50225", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SOCS box", "eco_id": "ECO_0000259", "start_pos": 377, "end_pos": 421, "start_aa": "Phe", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 302 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 37, "end_pos": 39 }, { "start_pos": 77, "end_pos": 79 }, { "start_pos": 80, "end_pos": 82 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": 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"sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": 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"MQQAPQPYEFYSEENSPKWRGLLVSALRKVQEQVHPNLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFSNILDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAESIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKIRSEEHEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYNRQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHSQSRLPGCSSAEYRLKEKFVMRKIQICDKEDTCECKHAFELVSKDENSIIYAAKSAEEKNNWMAALISLQYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADKLALEKGEQPISTDLKRFRKEYVQPVQLRVLNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAILSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDDAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPEMRRFFENLNPMGCASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSAFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLPPRKKFDQDASNSKGTMKSDDDPPAIPPRQPPPPKVKPRVPAPAGPFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFTLQPPPLGHLHRDPDWFRDVSTCPNSPNTPPSTPSPRVPRRCYVLSSSQNNLAHPQAPPVPPRQNSSPHLPKLPPKTYKRELSHPPVYRLPLLENAETPQ", "length": 1295, "header": "tr|A0A3Q1MAC7-1|L2HDH_BOVIN Computationally mapped isoform of L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=L2HGDH PE=2 SV=2 CANONICAL=A7MBI3-1" }, "locus": { "chromosome": "10", "start_pos": 43157582, "end_pos": 43053811, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071137.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071137.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067558.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067558.2" } ] } }, { "isoform_ac": "A0A3Q1MN28-1", "url": "https://www.uniprot.org/uniprotkb/A7MBI3/entry#A0A3Q1MN28-1", "sequence": { "sequence": "MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFSNILDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPKFNENFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKIRSEEHEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYNRQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHSQSRLPGCSSAEYRLKEKFVMRKIQICDKEDTCECKHAFELVSKDENSIIYAAKSAEEKNNWMAALISLQYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADKLALEKGEQPISTDLKRFRKEYVQPVQLRVLNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAILSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDDAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPEMRRFFENLNPMGCASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSAFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLPPRKKFDQDASNSKGTMKSDDDPPAIPPRQPPPPKVKPRVPAPAGPFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFTLQPPPLGHLHRDPDWFRDVSTCPNSPNTPPSTPSPRVPRRCYVLSSSQNNLAHPQAPPVPPRQNSSPHLPKLPPKTYKRELSHPPVYRLPLLENAETPQ", "length": 1272, "header": "tr|A0A3Q1MN28-1|L2HDH_BOVIN Computationally mapped isoform of L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=L2HGDH PE=2 SV=2 CANONICAL=A7MBI3-1" }, "locus": { "chromosome": "10", "start_pos": 43132710, "end_pos": 43053811, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076144.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076144.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072620.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072620.2" } ] } }, { "isoform_ac": "A0AAA9SJW9-1", "url": "https://www.uniprot.org/uniprotkb/A7MBI3/entry#A0AAA9SJW9-1", "sequence": { "sequence": "MVPALRYLGSVCGRARGIFPGGFSAAHTPASGKSRLLCQGGRRASTSSFDIVIIGGGIVGLASARALILRHPALSIGVLEKEKNLAVHQTGHNSGVIHSGIYYKPESLKAKLCVQGAALIYEYCNQKGISYKQCGKLIVAVEQEEIPRLQALYERGLQNGVQGLRLIQQEDIKKKEPYCRGLMAIDCPYTGIVDYRQVAFSFAKDFQEAGGSVLTNFEVEDIEMARESPSRSKDGMKYPIVIRNTKGEEVRCQYVVTCAGLYSDRISELSGCNPNPRIVPFRGDYLVLKPEKRYLVKGNIYPVPDSRFPFLGVHFTPRMDGNIWLGPNAILAFKREGYRPFDFSARDIMDIIIKSGLIKLVFQNFSYGVNEMYKACFLSATVKHLQKFIPEITISDVLRFRSKYIPISQLMKSLSITLKS", "length": 420, "header": "tr|A0AAA9SJW9-1|L2HDH_BOVIN Computationally mapped isoform of L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=L2HGDH PE=2 SV=1 CANONICAL=A7MBI3-1" }, "locus": { "chromosome": "10", "start_pos": 43219792, "end_pos": 43132740, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123331.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123331.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084134.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084134.1" } ] } }, { "isoform_ac": "A0AAA9T7X1-1", "url": "https://www.uniprot.org/uniprotkb/A7MBI3/entry#A0AAA9T7X1-1", "sequence": { "sequence": "MQQAPQPYEFYSEENSPKWRGLLVSALRKERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFSNILDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPKFNENFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKIRSEEHEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYNRQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHSQSRLPGCSSAEYRLKEKFVMRKIQICDKEDTCECKHAFELVSKDENSIIYAAKSAEEKNNWMAALISLQYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADKLALEKGEQPISTDLKRFRKEYVQPVQLRVLNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAILSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDDAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPEMRRFFENLNPMGCASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSAFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLPPRKKFDQDASNSKGTMKSDDDPPAIPPRQPPPPKVKPRVPAPAGPFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFTLQPPPLGHLHRDPDWFRDVSTCPNSPNTPPSTPSPRVPRRCYVLSSSQNNLAHPQAPPVPPRQNSSPHLPKLPPKTYKRELSHPPVYRLPLLENAETPQ", "length": 1290, "header": "tr|A0AAA9T7X1-1|L2HDH_BOVIN Computationally mapped isoform of L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=L2HGDH PE=2 SV=1 CANONICAL=A7MBI3-1" }, "locus": { "chromosome": "10", "start_pos": 43157582, "end_pos": 43053811, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121416.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121416.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092884.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092884.1" } ] } }, { "isoform_ac": "A0AAA9TER1-1", "url": "https://www.uniprot.org/uniprotkb/A7MBI3/entry#A0AAA9TER1-1", "sequence": { "sequence": "MQQAPQPYEFYSEENSPKWRGLLVSALRKVQEQVHPNLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFSNILDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPKFNENFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKIRSEEHEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYNRQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHSQSRLPGCSSAEYRLKEKFVMRKIQICDKEDTCECKHAFELVSKDENSIIYAAKSAEEKNNWMAALISLQYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADKLALEKGEQPISTDLKRFRKEYVQPVQLRVLNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAILSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDDAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPEMRRFFENLNPMGCASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSAFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCAIASLLQSSCLIQGTMKSDDDPPAIPPRQPPPPKVKPRVPAPAGPFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFTLQPPPLGHLHRDPDWFRDVSTCPNSPNTPPSTPSPRVPRRCYVLSSSQNNLAHPQAPPVPPRQNSSPHLPKLPPKTYKRELSHPPVYRLPLLENAETPQ", "length": 1294, "header": "tr|A0AAA9TER1-1|L2HDH_BOVIN Computationally mapped isoform of L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=L2HGDH PE=2 SV=1 CANONICAL=A7MBI3-1" }, "locus": { "chromosome": "10", "start_pos": 43157582, "end_pos": 43053811, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131344.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131344.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095463.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095463.1" } ] } }, { "isoform_ac": "A7MBI3-1", "url": "https://www.uniprot.org/uniprotkb/A7MBI3/entry#A7MBI3-1", "sequence": { "sequence": "MVPALRYLGSVCGRARGIFPGGFSAAHTPASGKSRLLCQGGRRASTSSFDIVIIGGGIVGLASARALILRHPALSIGVLEKEKNLAVHQTGHNSGVIHSGIYYKPESLKAKLCVQGAALIYEYCNQKGISYKQCGKLIVAVEQEEIPRLQALYERGLQNGVQGLRLIQQEDIKKKEPYCRGLMAIDCPYTGIVDYRQVAFSFAKDFQEAGGSVLTNFEVEDIEMARESPSRSKDGMKYPIVIRNTKGEEVRCQYVVTCAGLYSDRISELSGCNPNPRIVPFRGDYLVLKPEKRYLVKGNIYPVPDSRFPFLGVHFTPRMDGNIWLGPNAILAFKREGYRPFDFSARDIMDIIIKSGLIKLVFQNFSYGVNEMYKACFLSATVKHLQKFIPEITISDVLRGPAGVRAQALDRDGNLIEDFVFDGGVGDIGNRILHVRNAPSPAATSSLAISGMIADEVQQRFKL", "length": 463, "header": "sp|A7MBI3-1|L2HDH_BOVIN Isoform 1 of L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=L2HGDH PE=2 SV=1 CANONICAL=A7MBI3-1" }, "locus": { "chromosome": "10", "start_pos": 43219792, "end_pos": 43168637, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020226.5", "url": "https://www.ensembl.org/id/ENSBTAT00000020226.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020226.3", "url": "https://www.ensembl.org/id/ENSBTAP00000020226.3" } ] } }, { "isoform_ac": "F1N1J9-1", "url": "https://www.uniprot.org/uniprotkb/A7MBI3/entry#F1N1J9-1", "sequence": { "sequence": "MQQAPQPYEFYSEENSPKWRGLLVSALRKVQEQVHPNLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFSNILDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPKFNENFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKIRSEEHEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYNRQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHSQSRLPGCSSAEYRLKEKFVMRKIQICDKEDTCECKHAFELVSKDENSIIYAAKSAEEKNNWMAALISLQYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADKLALEKGEQPISTDLKRFRKEYVQPVQLRVLNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAILSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDDAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPEMRRFFENLNPMGCASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSAFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLPPRKKFDQDASNSKGTMKSDDDPPAIPPRQPPPPKVKPRVPAPAGPFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFTLQPPPLGHLHRDPDWFRDVSTCPNSPNTPPSTPSPRVPRRCYVLSSSQNNLAHPQAPPVPPRQNSSPHLPKLPPKTYKRELSHPPVYRLPLLENAETPQ", "length": 1332, "header": "tr|F1N1J9-1|L2HDH_BOVIN Computationally mapped isoform of L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=L2HGDH PE=2 SV=3 CANONICAL=A7MBI3-1" }, "locus": { "chromosome": "10", "start_pos": 43157582, "end_pos": 43053811, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007299.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007299.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007299.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007299.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:100138040", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138040", "resource": "KEGG Pathway" }, { "id": "bta:514230", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514230", "resource": "KEGG Pathway" }, { "id": "R-BTA-416482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "resource": "Reactome", "description": "G alpha (12/13) signalling events" }, { "id": "R-BTA-880009", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-880009", "resource": "Reactome", "description": "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" }, { "id": "R-BTA-8983432", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8983432", "resource": "Reactome", "description": "Interleukin-15 signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZQZ4-1", "protein_name": "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "gene_name": "L2HGDH", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVPALRYLGSVYGRARGAFSGGFLAAGAPAPGNLWLLCQGGRRASTSSFDVVIIGGGIVGLASARALILRHPALSIGVLEKEKDLAIHQTGHNSGVIHSGIYYKPESLKAKLCVQGAALIYEYCNQKGISYKQCGKLIVAVEQEEIPRLQALYERGLQNGVQGLRLIQQEDIKKKEPYCRGLMAIDCPYTGIVDYRQVALSFAQDFQEAGGSVLTSFEVEDIEMAKESPSRHKDGMKYPIVIRNTKGEEVRCQYVVTCAGLYSDRISELSGCNPNPRIVPFRGDYLLLKPEKRYLVKGNIYPVPDSRFPFLGVHFTPRMDGSIWLGPNAVLAFKREGYRPFDFSARDIMDIILKSGLMKLVFQNFSYGVNEMYKACFLSATVKHLQKFIPEITISDILRLTIDPMVSFIKCPKLSCLELANGVCCSLS", "length": 428 }, "evidence": [ { "id": "A7MBI3", "url": "https://omabrowser.org/oma/group/A7MBI3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZGL8-1", "protein_name": "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "gene_name": "L2HGDH", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAALLGRRCCGAAAVALWRAQRRQRSTFDVAVVGAGIVGLAAARQLVLRHPALGFAVLEKERQLAHHQSGHNSGVIHSGIYYTPGSLKAKLCVQGAALCYEYCDRKGIPYKQCGKLIVAVEQDEIPRLKALYERGLQNNVRGLKLIGAKEIQAKEPFCRGLMALDSPYTGIVDYRQVAQSYAEDFQEAGGTILTDFEVTDMEMAKESSSGSEDGLQYPVVVRSSKGEEIYCRHIVTCAGLYSDRLSEISGCSPEPRIVPFRGDYLVLKPEKCYMVKGNIYPVPNPRFPFLGFHFTPRMDGSVWLGPNAVLAFKREGYKLFDFSATDFLDAVLYSGLWKLVLKNLSYGLSEMYRACFLSAQVEELQKFIPEVTVNDVLRGPSGVRAQALDSDGNLVDDFVFDGGTGDLGSRILHVRNAPSPAATSSLAIAEMIADEVKQRFEL", "length": 442 }, "evidence": [ { "id": "A7MBI3", "url": "https://omabrowser.org/oma/group/A7MBI3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0M1M3-1", "protein_name": "SOS Ras/Rho guanine nucleotide exchange factor 2", "gene_name": "Sos2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSFSPHIRVLPSRAAVTAPGSPRAARIRFVCRDSDAAAECVWNSRPAPAHVPRRDRLPSRPPGPAPGAWARSAARMLGAGLLPRLGRASAGPSRAAAAGTRRSAAARGAGGAASAVHAGHARPLGPEGPLEVQEQVHPTLSANEESLYYIEELIFQLLNKLCLAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDDIGLVSLCEEEPCSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDKKLFKSSEIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILAPEFNDHFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQHSPRRRPGDPVCLFYNRQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHCQTRLPGYSSAEYRLKEKFVMRKIQICDKEDACEYKHAFELVSKDENSVIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPRPDVYRFVVTDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPDPEPTEADKLALEKGEQPISADLKRFRKEYVQPVQLRVLNVFRHWVEHHFYDFERDLELLERLEAFISSVRGKAMKKWVESIAKIIKRKKQAQANGVSHNITFESPPPPVEWHISRAGQSETFDLMTLHPIEIARQLTLLESDLYRRVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIVEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRRVLDDAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNSDFLKRKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRTEPEMRRFFENLNPMGLLSEKEFTDYLFNKSHEIEPRNCKQPPRFPRKSTFSLKSPGIRPNASRHGSTSGTFRGHPTPLEREPYKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDHSVFLDVDLNSSCGSNTIFAPVLLPHSKSFFSSCGSLHKLSEEPLVPPPLPPRKKFDHDAPNSKGAMKSDDDPPAIPPRQPPPPKVKPRAPVLTGTFEGPVPSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHPHRDPDWLRDVSTCPNSPSTPPPTPSPRIPRRCHLPSPSHNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLYRLPLFENAETPQ", "length": 1435 }, "evidence": [ { "id": "A7MBI3", "url": "https://omabrowser.org/oma/group/A7MBI3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B8A6D3-1", "protein_name": "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "gene_name": "l2hgdh", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLCGIMMRTFGSGSVCARLLSQRAKSATCRAAHHSGSFDVAIIGGGIVGLASARELILRHPNLSFALLEKEKELALHQTGHNSGVIHTGIYYTPGSLKAQLCVRGATLAYEYCQKKGVPYNRCGKLIVAVDREEIPRLKALYERGQKNNVRDLRLIDAKAIREKEPYCRGIMALDSPYTGIVDWREVALAYGKDFQEAGGTVMTDYEASDMSVAAESQADSTNGQKYPIIIRSSQGKEVRCAFVLACGGLYSDRLSEMSGCSSEPRIVPFRGDYLVLKPEKNYLVRGNIYPVPNPRFPFLGVHFTPRMDGSVWLGPNAVLAFKREGYKLFDFDAQDFVNALSFSGLQRLVMKNVVYGVGEIYRGVFPGAQVKILQKFIPELSPSDVIRGPSGVRAQALDAEGNLVDDFVFDGGKGELGSRVLHVRNAPSPAASSSLAIAEMIADELEKRFQL", "length": 452 }, "evidence": [ { "id": "A7MBI3", "url": "https://omabrowser.org/oma/group/A7MBI3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1N8Q9-1", "protein_name": "SOS Ras/Rho guanine nucleotide exchange factor 2", "gene_name": "SOS2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQPPPQPYEFFGEENGPKWRGLFVPALRKVQQQVHPNLSAKEDSLYYIEELILQLLNKLCIAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPLLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHFEISQQDIKVSMCADKVLMDMFDQDDIGLVSLCEDEPSSSGELNYYDLVRNEIAEERQYLRELNLIIKVFREAFLSNRKLFTPNDIDVVFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPQFHEHFNNLMAKPAVALYFQSTAEGFKEAVRYVLPRLMLIPVYHCLHYFELLQQLQECSEDEEDRECLKQAITALLNLQCSMERIYSKHSPRRRPGEPVCRFYNRQIRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTKIGAKHERHIFLFDGLMISCKTNHGQSRLPGYSNAEYRLKEKIIMRKIQIIDKDDTSEYKHAFELVSKDENSILFAAKSAEEKSNWMAALISLQYRSTLDRMLDSVLLQEENEQPLRLPSPNVYRFVVEDSEDNIVFEDNLQSRNGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADRLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLETFISSVRGKSMKKWVESIAKIIKRKKAQANGISHNITFESPPPPIEWHIWRVGHSEMLDLMTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAMNSVSVYRLDHTFEALQERKKRVLDEAVELSQDHFKKYLAKLKSINPPCVPFFGIYLTNILKTEEGNPDFLKRQGKELINFSKRRKVAEITGEIQQYQNQPYCLRIEPEIRKFFENLNPMGKIPEKEFTDYLFNKSLEIEPRNCKQPPRFPRKTTYPLKSPGIRPNAGRHGSTSGTLRSHPLPLEKEPSKICFSRITEAEHESAVSAPTSPNTPSTPPVSASSEFSVFLDIDLNSSYGNNSIFAPVSLPQSKTFFSSWGSFPKLSDEPQNPPPLPPRKKMDQDVSNAKGSLKSDDDPPAIPPRQPPPPKIQPRAPAYSPFEQPLHSPPPPPPRDPLPDTPPPVPHRPPEHFINCPLNLQPPPVGRMHRDADWFREAGPGPSSPGTPPSTPSPRVLRRCCVIGAAHNSPGHPPAPPVPPRQNSSPQLPKLPPKTYKRELSHPPLHRLSLLENAEAPQ", "length": 1330 }, "evidence": [ { "id": "A7MBI3", "url": "https://omabrowser.org/oma/group/A7MBI3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1R019-1", "protein_name": "Son of sevenless homolog 2", "gene_name": "sos2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MQHDFSSSEENSARWRGLFVQGLRKVQVQVHPNLSAKEDALQHIEALILQLLNKLCVTQPRTIADVEDRVQKTFPNPIDKWAMGDAQNAIEKRKRRNPLLLPVDKIHPLLKEVLGYKIDYNVCLYIVAVLEYISADILKLAGNYVSNIRHYEISQQDITVSMCADKVLMDMFDQEEEMGLLSQSVEEVSSSGVLTYDDLVRLEIAEERQYLRELDLIIKVFRQAFMSNSKLFSAQDVELAFSNILEVQELTVKLLGLIEDAVEMTADGSPHPLVGSCFEDLAEEQAFDPYETLSQDILSKEFCQHFNTLMSRPTVALHFQSIAEGFKEAVQYVLPQLMMVPVYHCIHYFELLQQLQECSEEQDDRECLKQAQTALINLQCSIERIYAKHQPRRKQGEPLYRLYSRASRSKQAAIKRMNDIQKSIDGWEGKDIGQCCSQFILEGALLRAGAKHERHNFLFDGLMISCKANQSSRLPGAGSGAEFRLKEKFVLRKYRIVDREDSPEFRHAFELVGREESGAVFSARSAEEKSAWMAALVTLQYRPTLDRMLDTVLHREEQAQPLRLPSPDVYRFAIQDSEENIVFEEGAQSKTGIPIIKAGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQDLLTLLIERIEIPEPEPSEADREALWNGEQPMAAELQRFRREYVQPVQLRVLNVFRQWVEHHFYDFENDPELYERLEGYLISTTQLRGKSMRKWVESISKIMRRKIQMQSNGISHNITFESPPPPIEWHISRPGQVDTFDLMTLHPIEIARQLTLLESDLYRAVRPSELVGSVWTKEDKEKNSPNLLRMIRHTTNLTLWFEKCIVEAENVDERVAVFSRIIEILQVFQELNNFNGVLEIVSAINSVPVYRLDHTFEAVPERKRRILEEAVELSQDHFKKYLAKLKSINPPCVPFFGIYLTNILKTEEGNPDFLKRDGKELINFSKRRKVAEITGEIQQYQNQPYCLKVEHDIKRFFENLNPMGNMNEKDFSDYLFNKSLEIEPRNSKQPPRFPRKTTYSLKSPGVRPVRQAVGGGGTLKGHPVPLEREPPHKITFRSIAETEPETPPSLPTSPNTPTPPQSASSDFNSVFEQDFMPYGNNTIFAPVFLPQSKFQSVSCGSLHQLMSDEPLKPPPLPPRRKDTSSDKNSRSDSPPAIPPRLPPPPRLQPRVPVINGPTDGPLPSPPPPLPRDPLPDTPPPVPQRPPEIFINYPVNMQPSPGGRFHWDFTTSPSTPNTPPGTPSPRAVLPGTPSPRVPRRPCTPSVSQPILVHLPPPTPAPPIPPRHNSTSALPKLPPKTYKRELSQSSHTLSQPSLHTLSLVDNRDSNE", "length": 1341 }, "evidence": [ { "id": "A7MBI3", "url": "https://omabrowser.org/oma/group/A7MBI3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1SHY0-1", "protein_name": "SOS Ras/Rho guanine nucleotide exchange factor 2", "gene_name": "SOS2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPNLSANEESLYYIEELIFQLLNKLCLAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFSNILDIHELTVKLLGLVEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPEFNEHFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALLNLQGSMDRIYKQHSPRRRPGDPVCPFYNRQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRVGAKHERHIFLFDGLMISCKPNHSQSRLPGYSNAEYRLKEKFVMRKIQICDKEDTCEYKHAFELVSKDENSIIFAAKSAEEKSNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADKLAVEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPEMRRFFENLNPMGNSSEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETDLESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPAPTGVFDGPLPSPPLPPPRDPLPDTPPPVPLRPPEHFINCPFTLQPPPLGHLHRDPDWFRDVSMCPNSPNTPPSTPSPRVPRRCYVLSSSQNNLAHPQAPPIPPRQNSSPHLPKLPPKTYKRELSHPPLYRLPLLENAETPQ", "length": 1332 }, "evidence": [ { "id": "A7MBI3", "url": "https://omabrowser.org/oma/group/A7MBI3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P26675-1", "protein_name": "Protein son of sevenless", "gene_name": "Sos", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFSGPSGHAHTISYGGGIGLGTGGGGGSGGSGSGSQGGGGGIGIGGGGVAGLQDCDGYDFTKCENAARWRGLFTPSLKKVLEQVHPRVTAKEDALLYVEKLCLRLLAMLCAKPLPHSVQDVEEKVNKSFPAPIDQWALNEAKEVINSKKRKSVLPTEKVHTLLQKDVLQYKIDSSVSAFLVAVLEYISADILKMAGDYVIKIAHCEITKEDIEVVMNADRVLMDMLNQSEAHILPSPLSLPAQRASATYEETVKELIHDEKQYQRDLHMIIRVFREELVKIVSDPRELEPIFSNIMDIYEVTVTLLGSLEDVIEMSQEQSAPCVGSCFEELAEAEEFDVYKKYAYDVTSQASRDALNNLLSKPGASSLTTAGHGFRDAVKYYLPKLLLVPICHAFVYFDYIKHLKDLSSSQDDIESFEQVQGLLHPLHCDLEKVMASLSKERQVPVSGRVRRQLAIERTRELQMKVEHWEDKDVGQNCNEFIREDSLSKLGSGKRIWSERKVFLFDGLMVLCKANTKKQTPSAGATAYDYRLKEKYFMRRVDINDRPDSDDLKNSFELAPRMQPPIVLTAKNAQHKHDWMADLLMVITKSMLDRHLDSILQDIERKHPLRMPSPEIYKFAVPDSGDNIVLEERESAGVPMIKGATLCKLIERLTYHIYADPTFVRTFLTTYRYFCSPQQLLQLLVERFNIPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHWVDHHFYDFEKDPMLLEKLLNFLEHVNGKSMRKWVDSVLKIVQRKNEQEKSNKKIVYAYGHDPPPIEHHLSVPNDEITLLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDKEVKSPNLLKIMKHTTNVTRWIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERYRKFLEECRELSDDHLKKYQERLRSINPPCVPFFGRYLTNILHLEEGNPDLLANTELINFSKRRKVAEIIGEIQQYQNQPYCLNEESTIRQFFEQLDPFNGLSDKQMSDYLYNESLRIEPRGCKTVPKFPRKWPHIPLKSPGIKPRRQNQTNSSSKLSNSTSSVAAAAAASSTATSIATASAPSLHASSIMDAPTAAAANAGSGTLAGEQSPQHNPHAFSVFAPVIIPERNTSSWSGTPQHTRTDQNNGEVSVPAPHLPKKPGAHVWANNNSTLASASAMDVVFSPALPEHLPPQSLPDSNPFASDTEAPPSPLPKLVVSPRHETGNRSPFHGRMQNSPTHSTASTVTLTGMSTSGGEEFCAGGFYFNSAHQGQPGAVPISPHVNVPMATNMEYRAVPPPLPPRRKERTESCADMAQKRQAPDAPTLPPRDGELSPPPIPPRLNHSTGISYLRQSHGKSKEFVGNSSLLLPNTSSIMIRRNSAIEKRAAATSQPNQAAAGPISTTLVTVSQAVATDEPLPLPISPAASSSTTTSPLTPAMSPMSPNIPSHPVESTSSSYAHQLRMRQQQQQQTHPAIYSQHHQHHATHLPHHPHQHHSNPTQSRSSPKEFFPIATSLEGTPKLPPKPSLSANFYNNPDKGTMFLYPSTNEE", "length": 1596 }, "evidence": [ { "id": "A7MBI3", "url": "https://omabrowser.org/oma/group/A7MBI3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q02384-1", "protein_name": "Son of sevenless homolog 2", "gene_name": "Sos2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQQAPQPYEFFSEENSPKWRGLLVPALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDDIGLVSLCEDEPCSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLLDRKLFKPSEIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILAPEFNDHFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDKECLNQAITALMNLQGSMDRIYKQHSPRRRPGDPVCLFYNRQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDACEYRHAFELVSKDENSVIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPDMYRFVVTDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLNLLIERFEIPEPEPTEADKLALEKGEQPISADLKRFRKEYVQPVQLRVLNVFRHWVEHHYYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIKRKKQAQANGISHNITFESSPPPVEWHISRTGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIVEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRRILDDAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNSDFLKRKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRTEPEMRRFFENLNPMGILSEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNAGRHGSTSGTLRGHPTPLEREPYKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDHSVFLDVDLNSSCGSNTIFAPVLLPHSKTFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDALNSKGAVKSDDDPPAIPPRQPPPPKVKPRVPVLMGTFDGPVPSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHPHRDPDWLRDVSTCPNSPSTPPTTPSPRIPRSCHLLSSSHSSLAHLPAPPVPPRQNSSPLLPKLPPKTYKRELSHPPLYRLPLLENAETPQ", "length": 1333 }, "evidence": [ { "id": "A7MBI3", "url": "https://omabrowser.org/oma/group/A7MBI3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q07890-1", "protein_name": "Son of sevenless homolog 2", "gene_name": "SOS2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQQAPQPYEFFSEENSPKWRGLLVSALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPEFHEHFNKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLYRLPLLENAETPQ", "length": 1332 }, "evidence": [ { "id": "A7MBI3", "url": "https://omabrowser.org/oma/group/A7MBI3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91YP0-1", "protein_name": "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "gene_name": "L2hgdh", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWPTLRYVGGVCGLARYCVAGGFLRASGPASGVPGLLCGGGRRSSSTSSFDIVIVGGGIVGLASARTLILKHPGLSIGVVEKEKDLALHQTGHNSGVIHSGIYYKPESLKAKLCVEGAALIYEYCNLKGIPYRQCGKLIVAVEQEEIPRLQALYERGLQNGVEGLRLIQQEDIKKKEPYCRGLMAIDCPYTGIVNYQQVALSFAQDFQEAGGSILRDFEVKGIEIAKENSSRSKDGMNYPIAVKNSKGKEIRCRYVVTCAGLYSDRISELSGCNPDPQIVPFRGDYLVLKPEKGYLVKGNIYPVPDSRFPFLGVHFTPRLDGTIWLGPNAVLAFKREGYRPFDFDARDVMEVILKSGFINLVFQHFSYGVNEMYKACFLSETVKHLQKFIPEITISDVLRGPAGVRAQALDRDGNLVEDFVFDGGTGEIADRVLHVRNAPSPAATSSLAISRMIAEEAQQRFKL", "length": 464 }, "evidence": [ { "id": "A7MBI3", "url": "https://omabrowser.org/oma/group/A7MBI3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H9P8-1", "protein_name": "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "gene_name": "L2HGDH", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVPALRYLVGACGRARGLFAGGSPGACGFASGRPRPLCGGSRSASTSSFDIVIVGGGIVGLASARALILRHPSLSIGVLEKEKDLAVHQTGHNSGVIHSGIYYKPESLKAKLCVQGAALLYEYCQQKGISYKQCGKLIVAVEQEEIPRLQALYEKGLQNGVPGLRLIQQEDIKKKEPYCRGLMAIDCPHTGIVDYRQVALSFAQDFQEAGGSVLTNFEVKGIEMAKESPSRSIDGMQYPIVIKNTKGEEIRCQYVVTCAGLYSDRISELSGCTPDPRIVPFRGDYLLLKPEKCYLVKGNIYPVPDSRFPFLGVHFTPRMDGSIWLGPNAVLAFKREGYRPFDFSATDVMDIIINSGLIKLASQNFSYGVTEMYKACFLGATVKYLQKFIPEITISDILRGPAGVRAQALDRDGNLVEDFVFDAGVGDIGNRILHVRNAPSPAATSSIAISGMIADEVQQRFEL", "length": 463 }, "evidence": [ { "id": "A7MBI3", "url": "https://omabrowser.org/oma/group/A7MBI3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9LES4-1", "protein_name": "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "gene_name": "L2HGDH", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MKHKPETAAFSLIRPLEAWAANANKACNTKKMLPCLGRKWMRLSTRNLKPTWNLINVVDASKTIVRGISGGAETIAKERVDTVVIGAGVVGLAVARELSLRGREVLILDAASSFGTVTSSRNSEVVHAGIYYPPNSLKAKFCVRGRELLYKYCSEYEIPHKKIGKLIVATGSSEIPKLDLLMHLGTQNRVSGLRMLEGFEAMRMEPQLRCVKALLSPESGILDTHSFMLSLVEKSFDFMVYRDNNNLRLQGEAQNNHATFSYNTVVLNGRVEEKKMHLYVADTRFSESRCEAEAQLELIPNLVVNSAGLGAQALAKRLHGLDHRFVPSSHYARGCYFTLSGIKAPPFNKLVYPIPEEGGLGVHVTVDLNGLVKFGPDVEWIECTDDTSSFLNKFDYRVNPQRSEKFYPEIRKYYPDLKDGSLEPGYSGIRPKLSGPKQSPADFVIQGEETHGVPGLVNLFGIESPGLTSSLAIAEHIANKFLR", "length": 483 }, "evidence": [ { "id": "A7MBI3", "url": "https://omabrowser.org/oma/group/A7MBI3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VJ28-1", "protein_name": "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "gene_name": "L2HGDH", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAQVRLLVQGLRRSLLNVGVAAPNESTATHKRSQHSSSSCGDYDLVVVGGGIVGAASAREIVLRHPSLKVAVLEKECKLAKHQSGHNSGVIHAGIYYKPGTLKARLCVEGMHLAYAYLDEKKIPYKKTGKLIVATDEKEVKLLKDLEKRGIANNVPDLRMIEGSEIQEIEPYCQGVMALHSPHTGIVDWGLVTEHYGQDFKQCGGDIYLDFNVSKFTETKEGTDYPVTIHGAKPGQTVRTKNVLTCGGLQSDLLAEKTGCPRDPRIVPFRGEYLLLTKEKQHMVKGNIYPVPDPRFPFLGVHFTPRMDGSIWLGPNAVLALKREGYTWGDINLFELFDALRYPGFVKMASKYIGFGLSEMSKSWFINLQIKALQKYIPDITEYDIQRGPAGVRAQAMDLDGNLVDDFVFDRGQGSGALAKRVLHCRNAPSPGATSSLAIAKMIADKIENEFSIGK", "length": 455 }, "evidence": [ { "id": "A7MBI3", "url": "https://omabrowser.org/oma/group/A7MBI3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A7MBI3", "url": "https://www.uniprot.org/uniprotkb/A7MBI3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A7MBI3", "url": "https://www.uniprot.org/uniprotkb/A7MBI3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "small molecule metabolic process", "id": "GO:0044281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044281", "evidence": [ { "database": "UniProtKB", "id": "A7MBI3", "url": "https://www.uniprot.org/uniprotkb/A7MBI3" } ], "pmid": "" }, { "name": "small GTPase-mediated signal transduction", "id": "GO:0007264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264", "evidence": [ { "database": "UniProtKB", "id": "A7MBI3", "url": "https://www.uniprot.org/uniprotkb/A7MBI3" } ], "pmid": "" }, { "name": "Ras protein signal transduction", "id": "GO:0007265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007265", "evidence": [ { "database": "UniProtKB", "id": "A7MBI3", "url": "https://www.uniprot.org/uniprotkb/A7MBI3" } ], "pmid": "" }, { "name": "insulin receptor signaling pathway", "id": "GO:0008286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008286", "evidence": [ { "database": "UniProtKB", "id": "A7MBI3", "url": "https://www.uniprot.org/uniprotkb/A7MBI3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "(S)-2-hydroxyglutarate dehydrogenase activity", "id": "GO:0047545", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047545", "evidence": [ { "database": "UniProtKB", "id": "A7MBI3", "url": "https://www.uniprot.org/uniprotkb/A7MBI3" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A7MBI3", "url": "https://www.uniprot.org/uniprotkb/A7MBI3" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A7MBI3", "url": "https://www.uniprot.org/uniprotkb/A7MBI3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 364, "end_pos": 366, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21252", "name": "", "equation": "(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A7MBI3-1" ], "evidence": [ { "id": "21252", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21252" } ] }, { "id": "R-BTA-880050", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane, mitochondrial matrix", "input_participant_list": [ "R-ALL-880013" ], "output_participant_list": [], "enzyme_list": [ "A7MBI3-1" ], "evidence": [ { "id": "R-BTA-880050", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-880050" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-880013", "participant_name": "(S)-2HG [mitochondrial matrix]", "crossref": [ { "id": "16782", "database": "ChEBI", "url": "" }, { "id": "5460355", "database": "PubChem Compound", "url": "" }, { "id": "C03196", "database": "KEGG Gene", "url": "" }, { "id": "13095-48-2", "database": "CAS", "url": "" }, { "id": "CPD-381", "database": "AraCyc", "url": "" }, { "id": "ZINC000000402967", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A7MBI3", "gene_name": "L2HGDH", "activity": [ { "ec_number": "1.1.99.2", "activity": "(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2.", "evidence": [ { "id": "A7MBI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBI3" } ] }, { "ec_number": "1.1.99.2", "activity": "", "evidence": [ { "id": "A7MBI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBI3" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7MBI3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 463, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7MBI3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7MBI3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.1.99.2", "ec_name": "(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2.", "evidence": [ { "id": "1.1.99.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.99.2" }, { "id": "1.1.99.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.1.99.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 364, "end_pos": 366 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BAX1-1", "uniprot_ac": "E1BAX1", "uniprot_id": "E1BAX1_BOVIN", "mass": { "chemical_mass": 50779.0, "monoisotopic_mass": 50779.0 }, "refseq": { "ac": "NP_001193086", "name": "Golgi-associated PDZ and coiled-coil motif-containing protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193086" }, "gene_names": [ { "name": "GOPC", "type": "recommended", "evidence": [ { "id": "E1BAX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAX1" } ] }, { "name": "GOPC", "type": "synonym", "evidence": [ { "id": "NP_001193086", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193086" } ] } ], "protein_names": [ { "name": "Golgi-associated PDZ and coiled-coil motif-containing protein", "type": "recommended", "evidence": [ { "id": "E1BAX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAX1/entry#names_and_taxonomy" } ] }, { "name": "CFTR-associated ligand", "type": "synonym", "evidence": [ { "id": "E1BAX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAX1/entry#names_and_taxonomy" } ] }, { "name": "Golgi-associated PDZ and coiled-coil motif-containing protein", "type": "synonym", "evidence": [ { "id": "NP_001193086", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193086" } ] }, { "name": "PDZ protein interacting specifically with TC10", "type": "synonym", "evidence": [ { "id": "E1BAX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAX1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAX1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GOPC", "url": "https://www.uniprot.org/uniprotkb/E1BAX1", "locus": { "chromosome": "9", "start_pos": 33228661, "end_pos": 33189369, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016046", "url": "https://www.ensembl.org/id/ENSBTAG00000016046" } ] } } ], "crossref": [ { "id": "E1BAX1", "url": "https://alphafold.ebi.ac.uk/entry/E1BAX1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016046", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016046", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06800", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06800", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14686", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14686", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "541186", "url": "https://www.ncbi.nlm.nih.gov/gene/541186", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541186", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541186", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QCNLRQE", "url": "https://omabrowser.org/oma/group/QCNLRQE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MCF2", "url": "https://www.orthodb.org/?gene=A0A3Q1MCF2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BAX1", "url": "https://www.orthodb.org/?gene=E1BAX1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16528", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16528", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16528:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16528:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5627083", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5627083", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013406", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013406", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193086", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCF2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCF2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6F2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6F2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6F2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHT3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXI5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXI5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXI5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXI5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAX1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAX1-1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAGGPCPAGAGGGSGGASCAVGVSPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQTVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSVDSGTIKAKLSVPSVEELERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMHAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGSSNPGASCKDTSGEIKMLQGFNKKAVTDGHENGDLGASSETPLEDNASKLDDLHSLYHKKSY", "length": 463, "header": "tr|E1BAX1-1|E1BAX1_BOVIN Isoform 1 of Golgi-associated PDZ and coiled-coil motif-containing protein OS=Bos taurus OX=9913 GN=GOPC PE=4 SV=2 CANONICAL=E1BAX1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MCF2-1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1/entry#A0A3Q1MCF2-1", "sequence": { "sequence": "MSAGGPCPAGAGGGSGGASCAVGVSPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQTVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSVDSGTIKAKLERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMHAPPGHGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGSSNPGASCKDTSGEIKMLQGFNKKAVTDGHENGDLGASSETPLEDNASKLDDLHSLYHKKSY", "length": 423, "header": "tr|A0A3Q1MCF2-1|E1BAX1_BOVIN Computationally mapped isoform of Golgi-associated PDZ and coiled-coil motif-containing protein OS=Bos taurus OX=9913 GN=GOPC PE=4 SV=2 CANONICAL=E1BAX1-1" }, "locus": { "chromosome": "9", "start_pos": 33226435, "end_pos": 33189614, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070505.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070505.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071797.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071797.2" } ] } }, { "isoform_ac": "A0AAA9S6F2-1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1/entry#A0AAA9S6F2-1", "sequence": { "sequence": "MSAGGPCPAGAGGGSGGASCAVGVSPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQTVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSVDSGTIKAKLSVPSVEELERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMHAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGSSNPGASCKDTSGEIKMLQGFNKKAVTDGHENGDLGASSETPLEDNASKLDDLHSLYHKKSY", "length": 408, "header": "tr|A0AAA9S6F2-1|E1BAX1_BOVIN Computationally mapped isoform of Golgi-associated PDZ and coiled-coil motif-containing protein OS=Bos taurus OX=9913 GN=GOPC PE=4 SV=1 CANONICAL=E1BAX1-1" }, "locus": { "chromosome": "9", "start_pos": 33226435, "end_pos": 33189614, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103511.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103511.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079466.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079466.1" } ] } }, { "isoform_ac": "A0AAA9SHT3-1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1/entry#A0AAA9SHT3-1", "sequence": { "sequence": "MSAGGPCPAGAGGGSGGASCAVGVSPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQTVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSVDSGTIKAKLERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMHAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGSSNPGASCKDTSGEIKMLQGFNKKAVTDGHENGDLGASSETPLEDNASKLDDLHRISLECLLSSVLFRRPLDPAGKSEKRCI", "length": 475, "header": "tr|A0AAA9SHT3-1|E1BAX1_BOVIN Computationally mapped isoform of Golgi-associated PDZ and coiled-coil motif-containing protein OS=Bos taurus OX=9913 GN=GOPC PE=4 SV=1 CANONICAL=E1BAX1-1" }, "locus": { "chromosome": "9", "start_pos": 33227657, "end_pos": 33189614, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096647.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096647.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084901.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084901.1" } ] } }, { "isoform_ac": "A0ABI0NXI5-1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1/entry#A0ABI0NXI5-1", "sequence": { "sequence": "MSAGGPCPAGAGGGSGGASCAVGVSPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQTVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSVDSGTIKAKLERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMHAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGSSNPGASCKDTSGEIKMLQGFNKKAVTDGHENGDLGASSETPLEDNASKLDDLHSLYHKKSY", "length": 455, "header": "tr|A0ABI0NXI5-1|A0ABI0NXI5_BOVIN Computationally mapped isoform of Golgi-associated PDZ and coiled-coil motif-containing protein OS=Bos taurus OX=9913 GN=GOPC PE=4 SV=1 CANONICAL=E1BAX1-1" }, "locus": { "chromosome": "9", "start_pos": 33226435, "end_pos": 33189614, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153188.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153188.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105954.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105954.1" } ] } }, { "isoform_ac": "E1BAX1-1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1/entry#E1BAX1-1", "sequence": { "sequence": "MSAGGPCPAGAGGGSGGASCAVGVSPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQTVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSVDSGTIKAKLSVPSVEELERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMHAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGSSNPGASCKDTSGEIKMLQGFNKKAVTDGHENGDLGASSETPLEDNASKLDDLHSLYHKKSY", "length": 463, "header": "tr|E1BAX1-1|E1BAX1_BOVIN Isoform 1 of Golgi-associated PDZ and coiled-coil motif-containing protein OS=Bos taurus OX=9913 GN=GOPC PE=4 SV=2 CANONICAL=E1BAX1-1" }, "locus": { "chromosome": "9", "start_pos": 33226435, "end_pos": 33189614, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021350.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021350.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021350.5", "url": "https://www.ensembl.org/id/ENSBTAP00000021350.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:541186", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541186", "resource": "KEGG Pathway" }, { "id": "R-BTA-5627083", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5627083", "resource": "Reactome", "description": "RHO GTPases regulate CFTR trafficking" }, { "id": "R-BTA-9013406", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013406", "resource": "Reactome", "description": "RHOQ GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A6H2-1", "protein_name": "Golgi-associated PDZ and coiled-coil motif-containing protein", "gene_name": "GOPC", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSAGGPCPAGAGGGPGGASCAVGVPPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQTVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSVDSGTIKAKLSVPSVEELERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMHAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGSTNPGASCKDASGEIKVLQGFNKKAVTDGHENGDLGTSSETPLEDSASKLDDLHSLYHKKSY", "length": 463 }, "evidence": [ { "id": "E1BAX1", "url": "https://omabrowser.org/oma/group/E1BAX1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I5ZTW6-1", "protein_name": "Golgi-associated PDZ and coiled-coil motif-containing protein", "gene_name": "Gopc", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSAGGPCPAGAGSGPGGASCPVGVSPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQTVSQINHKLEAQLVDLRSELTETQAEKVVLEKEVHDQLLQLHSTQLQLHAKTGQSVDSGAIKAKLVSKAGSALERELEANKTEKVKEARLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRQDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAVLAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNSGASCKDSSGEMKVLQGYNKKTVRDAHENGDVGASGESPLDDTAVRAAHPHSLHQKKAY", "length": 463 }, "evidence": [ { "id": "E1BAX1", "url": "https://omabrowser.org/oma/group/E1BAX1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0YF77-1", "protein_name": "Golgi-associated PDZ and coiled-coil motif-containing protein", "gene_name": "GOPC", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRAGTFRSPGCVAAPGEPGPPRGRRGTAEAGGSASRALCEARPGRAVAGGMSAAGGVGSCGPGGAACGGGVGGAASAPGGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQTVSQINHKLEAQLVDLKSELTETQAEKAVLEKEVHDQLLQLHAVQLQLHAQTGQNVDSGAIKAKLSVLSVDELERELEANKKEKVKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDPDALKKSQGVGPIRKVLLVKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDAKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEEGANSGSNRKEVNVDVKPSQVFDKKPSIDGHENGDLGNSVEPSLEDAAPKLTRSAESLS", "length": 512 }, "evidence": [ { "id": "E1BAX1", "url": "https://omabrowser.org/oma/group/E1BAX1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8BH60-1", "protein_name": "Golgi-associated PDZ and coiled-coil motif-containing protein", "gene_name": "Gopc", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAGGPCPAGAGGGPGGSSCPVGVSPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQTVSQINHKLEAQLVDLRSELTETQAEKVVLEKEVHEQLLQLHSTQLQLHAKTGQSVDSGAIKAKLSVHSVEDLERELEANKTEKVKEARLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGSGNSGASCKDSSGEMKMLQGYNKKAVRDAHENGDVGAAGESPLDDTAARAAHLHSLHQKKAY", "length": 463 }, "evidence": [ { "id": "E1BAX1", "url": "https://omabrowser.org/oma/group/E1BAX1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HD26-1", "protein_name": "Golgi-associated PDZ and coiled-coil motif-containing protein", "gene_name": "GOPC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY", "length": 462 }, "evidence": [ { "id": "E1BAX1", "url": "https://omabrowser.org/oma/group/E1BAX1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "E1BAX1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BAX1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1" } ], "pmid": "" }, { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "E1BAX1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "E1BAX1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1" } ], "pmid": "" }, { "name": "trans-Golgi network transport vesicle", "id": "GO:0030140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030140", "evidence": [ { "database": "UniProtKB", "id": "E1BAX1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "E1BAX1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BAX1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "E1BAX1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1" } ], "pmid": "" }, { "name": "negative regulation of protein localization to cell surface", "id": "GO:2000009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000009", "evidence": [ { "database": "UniProtKB", "id": "E1BAX1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BAX1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1" } ], "pmid": "" }, { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "E1BAX1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1" } ], "pmid": "" }, { "name": "molecular sequestering activity", "id": "GO:0140313", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140313", "evidence": [ { "database": "UniProtKB", "id": "E1BAX1", "url": "https://www.uniprot.org/uniprotkb/E1BAX1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 447, "end_pos": 449, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAX1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 463, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAX1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAX1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAX1" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 289, "end_pos": 372, "start_aa": "Lys", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 447, "end_pos": 449 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B7F2-1", "uniprot_ac": "E1B7F2", "uniprot_id": "E1B7F2_BOVIN", "mass": { "chemical_mass": 87468.0, "monoisotopic_mass": 87468.0 }, "refseq": { "ac": "XP_024834921", "name": "exocyst complex component 3-like protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834921" }, "gene_names": [ { "name": "EXOC3L2", "type": "recommended", "evidence": [ { "id": "E1B7F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7F2" } ] }, { "name": "EXOC3L2", "type": "synonym", "evidence": [ { "id": "XP_024834921", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834921" } ] } ], "protein_names": [ { "name": "Exocyst complex component 3 like 2", "type": "synonym", "evidence": [ { "id": "E1B7F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7F2/entry#names_and_taxonomy" } ] }, { "name": "exocyst complex component 3-like protein 2", "type": "synonym", "evidence": [ { "id": "XP_024834921", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834921" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7F2", "url": "https://www.uniprot.org/uniprotkb/E1B7F2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EXOC3L2", "url": "https://www.uniprot.org/uniprotkb/E1B7F2", "locus": { "chromosome": "18", "start_pos": 52852726, "end_pos": 52921140, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015836", "url": "https://www.ensembl.org/id/ENSBTAG00000015836" } ] } } ], "crossref": [ { "id": "E1B7F2", "url": "https://alphafold.ebi.ac.uk/entry/E1B7F2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015836", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015836", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01650", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01650", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539328", "url": "https://www.ncbi.nlm.nih.gov/gene/539328", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000477", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000477", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010326", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010326", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042532", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042532", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539328", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539328", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ANCVPPF", "url": "https://omabrowser.org/oma/group/ANCVPPF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7F2", "url": "https://www.orthodb.org/?gene=E1B7F2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21292", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21292", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21292:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21292:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00078", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00078", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024834921", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834921", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDX1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDX1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVT1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVT1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVT1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLJ4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NU70", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NU70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NU70-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NU70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P293", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P293", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P293-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P293-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7F2", "url": "https://www.uniprot.org/uniprotkb/E1B7F2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7F2-1", "url": "https://www.uniprot.org/uniprotkb/E1B7F2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPILKSLGVADSKVPRAGTLPLRSSRNPFEEVSGLEEEEAAELGALPNGTSCRRRATLEKLAGLSPFRLGKTPGRRAGSPRDGQPRSFLGRVLSPGIRRSSADFGLLARLQGSRAQGDEEAAGEAARRLAFLRLGRGPKPRRASLAERVVPAGEAAPEPPPKVPEPPKVKEPLSVLEILSLIQQRELARADEHILELEAEELASSGGGAPGPPKAEGAGGGRRARDVALLYEALQREMWALVRETLAGPGLGAGSGAGAVAQLGQVLVQEEAADGRRGPEAARKLRARWAEAVARAARERLEAAAPGAPGGLAGQLEALRGRLLEDMGVVRGRLAPSYPAGLGAFGVYLRGYHGALAEWMGAAARRRLPLADRYALLHWHNQVYPREVLGLVDMVALENGELGPLLSPGTLRGLEDECVTDVKAQTRAALLRVLQEDGEHWGSTEDWSSNLAQDVCELLEEHTERAPRISQEFGERMAHCCLGGLAEFLQSFQQRVERFHENPGVRELPPDTYISRTISLVNCGPPLRALAERLARVGPPESEPAREAAASALDRVIRLCHRILTDLLFQELQPHFSKLMRRKWLSSSEALDGIVGTLGAKALALRRMQDEPYQALVAELHRRALVEYVRPLFRGRLRCGSARTRSRVAGRLREDAAQLERLFRRLESQASWLDAVVPRLAEVLRLEDTPSIQMEVGVLVRDYPDIRQKHVATLLDIRGLRHTAARQEILAVTRDLELCEVAALSPPRDRAFFADIPVPRPPICLSLPLFLGRLTLSRLACLPWPRPPAPSPLRRPQARR", "length": 800, "header": "tr|E1B7F2-1|E1B7F2_BOVIN Isoform 1 of Exocyst complex component 3 like 2 OS=Bos taurus OX=9913 GN=EXOC3L2 PE=3 SV=3 CANONICAL=E1B7F2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MDX1-1", "url": "https://www.uniprot.org/uniprotkb/E1B7F2/entry#A0A3Q1MDX1-1", "sequence": { "sequence": "MPILKSLGVADSKVPRAGTLPLRSSRNPFEEVSGLEEEEAAELGALPNGTSCRRRATLEKLAGLSPFRLGKTPGRRAGSPRDGQPRSFLGRVLSPGIRRSSADFGLLARLQGSRAQGDEEAAGEAARRLAFLRLGRGPKPRRASLAERVVPAGEAAPEPPPKVPEPPKVKEPLSVLEILSLIQQRELARADEHILELEAEELASSGGGAPGPPKAEGAGGGRRARDVALLYEALQREMWALVRETLAGPGLGAGSGAGAVAQLGQVLVQEEAADGRRGPEAARKLRARWAEAVARAARERLEAAAPGAPGGLAGQLEALRGRLLEDMGVVRGRLAPSYPAGLGAFGVYLRGYHGALAEWMGAAARRRLPLADRYALLHWHNQVYPREVLGLVDMVALENGELGPLLSPGTLRGLEDECVTDVKAQTRAALLRVLQEDGEHWGSTEDWSSNLAQDVCELLEEHTERAPRISQEFGERMAHCCLGGLAEFLQSFQQRVERFHENPGVRELPPDTYISRTISLVNCGPPLRALAERLARVGPPESEPAREAAASALDRVIRLCHRILTDLLFQELQPHFSKLMRRKWLSSSEALDGIVGTLGAKALALRRMQDEPYQALVAELHRRALVEYVRPLFRGRLRCGSARTRSRVAGRLREDAAQLERLFRRLESQASWLDAVVPRLAEVLRLEDTPSIQMEVGVLVRDYPDIRFSSGHKNRSATQIARPPPPASAWCPPLFILLPLSATHNHPHQDVLRTTALRWSRWSTSALRLKEVRFFSRVPSLSFTGNVIKSISS", "length": 793, "header": "tr|A0A3Q1MDX1-1|E1B7F2_BOVIN Computationally mapped isoform of Exocyst complex component 3 like 2 OS=Bos taurus OX=9913 GN=EXOC3L2 PE=3 SV=2 CANONICAL=E1B7F2-1" }, "locus": { "chromosome": "18", "start_pos": 52914392, "end_pos": 52880291, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067152.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067152.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069161.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069161.2" } ] } }, { "isoform_ac": "A0AAA9RVT1-1", "url": "https://www.uniprot.org/uniprotkb/E1B7F2/entry#A0AAA9RVT1-1", "sequence": { "sequence": "MPILKSLGVADSKVPRAGTLPLRSSRNPFEEVSGLEEEEAAELGALPNGTSCRRRATLEKLAGLSPFRLGKTPGRRAGSPRDGQPRSFLGRVLSPGIRRSSADFGLLARLQGSRAQGDEEAAGEAARRLAFLRLGRGPKPRRASLAERVVPAGEAAPEPPPKVPEPPKVKEPLSVLEILSLIQQRELARADEHILELEAEELASSGGGAPGPPKAEGAGGGRRARDVALLYEALQREMWALVRETLAGPGLGAGSGAGAVAQLGQVLVQEEAADGRRGPEAARKLRARWAEAVARAARERLEAAAPGAPGGLAGQLEALRGRLLEDMGVVRGRLAPSYPAGLGAFGVYLRGYHGALAEWMGAAARRRLPLADRYALLHWHNQVYPREVLGLVDMVALENGELGPLLSPGTLRGLEDECVTDVKAQTRAALLRVLQEDGEHWGSTEDWSSNLAQDVCELLEEHTERAPRISQEFGERMAHCCLGGLAEFLQSFQQRVERFHENPGVRELPPDTYISRTISLVNCGPPLRALAERLARVGPPESEPAREAAASALDRVIRLCHRILTDLLFQELQPHFSKLMRRKWLSSSEALDGIVGTLGAKALALRRMQDEPYQALVAELHRRALVEYVRPLFRGRLRCGSARTRSRVAGRLREDAAQLERLFRRLESQASWLDAVVPRLAEVLRLEDTPSIQMEVGVLVRDYPDIRSRLMRTTFRPLRASCRRCIRLFIHESHKYLLCADSVLRCCRRCRCRETLCPLNNHSLTHVYGDGIPVELFQILKEDAVKVLHSICQQIWKTQQWTQDWKRSVFIPIPKKGNAKECSNYRTIALISQASKVMLKILQARLQQYMNREIPDVQAGLRKGRGTRDQTANIHWIIEKAREFQKNIYFCFIDYAKAFDSVDQNKLWKILKEMGIPDHLTCLLRNLYAGQEATVRTGHGTTDWFQIGKGVRQGCILSPCLFNLYAEYIMRTSGLDEAQAGIKIAGRNINNLRYADDTILMAESKEELKSLLMKVKVESEKVGLKLNVQKTKIMASGPIILWQIDGETMETVIDFIFFGSKITANGDYCCCCC", "length": 1073, "header": "tr|A0AAA9RVT1-1|E1B7F2_BOVIN Computationally mapped isoform of Exocyst complex component 3 like 2 OS=Bos taurus OX=9913 GN=EXOC3L2 PE=3 SV=1 CANONICAL=E1B7F2-1" }, "locus": { "chromosome": "18", "start_pos": 52914392, "end_pos": 52853580, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131223.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131223.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077488.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077488.1" } ] } }, { "isoform_ac": "A0ABI0NLJ4-1", "url": "https://www.uniprot.org/uniprotkb/E1B7F2/entry#A0ABI0NLJ4-1", "sequence": { "sequence": "MGVVRGRLAPSYPAGLGAFGVYLRGYHGALAEWMGAAARRRLPLADRYALLHWHNQVYPREVLGLVDMVALENGELGPLLSPGTLRGLEDECVTDVKLLEEHTERAPRISQEFGERMAHCCLGGLAEFLQSFQQRVERFHENPGVRELPPDTYISRTISLVNCGPPLRALAERLARVGPPESEPAREAAASALDRVIRLCHRILTDLLFQELQPHFSKLMRRKWLSSSEALDGIVGTLGAKALALRRMQDEPYQALVAELHRRALVEYVRPLFRGRLRCGSARTRSRVAGRLREDAAQLERLFRRLESQASWLDAVVPRLAEVLRLEDTPSIQMEVGVLVRDYPDIRQKHVATLLDIRGLRHTAARQEILAVTRDLELCEVAALSPPRDRAFFADIPVPRPPICLSLPLFLGRLTLSRLACLPWPRPPAPSPLRRPQARR", "length": 440, "header": "tr|A0ABI0NLJ4-1|A0ABI0NLJ4_BOVIN Computationally mapped isoform of Exocyst complex component 3 like 2 OS=Bos taurus OX=9913 GN=EXOC3L2 PE=3 SV=1 CANONICAL=E1B7F2-1" }, "locus": { "chromosome": "18", "start_pos": 52910497, "end_pos": 52898568, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000137297.1", "url": "https://www.ensembl.org/id/ENSBTAT00000137297.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106027.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106027.1" } ] } }, { "isoform_ac": "A0ABI0NU70-1", "url": "https://www.uniprot.org/uniprotkb/E1B7F2/entry#A0ABI0NU70-1", "sequence": { "sequence": "MGVVRGRLAPSYPAGLGAFGVYLRGYHGALAEWMGAAARRRLPLADRYALLHWHNQVYPREVLGLVDMVALENGELGPLLSPGTLRGLEDECVTDVKAQTRAALLRVLQEDGEHWGSTEDWSSNLAQDVCELLEEHTERAPRISQEFGERMAHCCLGGLAEFLQSFQQRVERFHENPGVRELPPDTYISRTISLVNCGPPLRALAERLARVGPPESEPAREAAASALDRVIRLCHRILTDLLFQELQPHFSKLMRRKWLSSSEALDGIVGTLGAKALALRRMQDEPYQALVAELHRRALVEYVRPLFRGRLRCGSARTRSRVAGRLREDAAQLERLFRRLESQASWLDAVVPRLAEVLRLEDTPSIQMEVGVLVRDYPDIRSRLMRTTFRPLRASCRRCIRLFIHESHKYLLCADSVLRCCRRCRCRAPWRSFLRLDGMQPDA", "length": 443, "header": "tr|A0ABI0NU70-1|A0ABI0NU70_BOVIN Computationally mapped isoform of Exocyst complex component 3 like 2 OS=Bos taurus OX=9913 GN=EXOC3L2 PE=3 SV=1 CANONICAL=E1B7F2-1" }, "locus": { "chromosome": "18", "start_pos": 52910497, "end_pos": 52864500, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153115.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153115.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107335.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107335.1" } ] } }, { "isoform_ac": "A0ABI0P293-1", "url": "https://www.uniprot.org/uniprotkb/E1B7F2/entry#A0ABI0P293-1", "sequence": { "sequence": "MGVVRGRLAPSYPAGLGAFGVYLRGYHGALAEWMGAAARRRLPLADRYALLHWHNQVYPREVLGLVDMVALENGELGPLLSPGTLRGLEDECVTDVKAQTRAALLRVLQEDGEHWGSTEDWSSNLAQDVCELLEEHTERAPRISQEFGERMAHCCLGGLAEFLQSFQQRVERFHENPGVRELPPDTYISRTISLVNCGPPLRALAERLARVGPPESEPAREAAASALDRVIRLCHRILTDLLFQELQPHFSKLMRRKWLSSSEALDGIVGTLGAKALALRRMQDEPYQALVAELHRRALVEYVRPLFRGRLRCGSARTRSRVAGRLREDAAQLERLFRRLESQASWLDAVVPRLAEVLRLEDTPSIQMEVGVLVRDYPDIRSRLMRTTFRPLRASCRRCIRLFIHESHKYLLCADSVLRCCRRCRCRGFAGSILGPGRFHMS", "length": 442, "header": "tr|A0ABI0P293-1|A0ABI0P293_BOVIN Computationally mapped isoform of Exocyst complex component 3 like 2 OS=Bos taurus OX=9913 GN=EXOC3L2 PE=3 SV=1 CANONICAL=E1B7F2-1" }, "locus": { "chromosome": "18", "start_pos": 52910497, "end_pos": 52858213, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000137987.1", "url": "https://www.ensembl.org/id/ENSBTAT00000137987.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104927.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104927.1" } ] } }, { "isoform_ac": "E1B7F2-1", "url": "https://www.uniprot.org/uniprotkb/E1B7F2/entry#E1B7F2-1", "sequence": { "sequence": "MPILKSLGVADSKVPRAGTLPLRSSRNPFEEVSGLEEEEAAELGALPNGTSCRRRATLEKLAGLSPFRLGKTPGRRAGSPRDGQPRSFLGRVLSPGIRRSSADFGLLARLQGSRAQGDEEAAGEAARRLAFLRLGRGPKPRRASLAERVVPAGEAAPEPPPKVPEPPKVKEPLSVLEILSLIQQRELARADEHILELEAEELASSGGGAPGPPKAEGAGGGRRARDVALLYEALQREMWALVRETLAGPGLGAGSGAGAVAQLGQVLVQEEAADGRRGPEAARKLRARWAEAVARAARERLEAAAPGAPGGLAGQLEALRGRLLEDMGVVRGRLAPSYPAGLGAFGVYLRGYHGALAEWMGAAARRRLPLADRYALLHWHNQVYPREVLGLVDMVALENGELGPLLSPGTLRGLEDECVTDVKAQTRAALLRVLQEDGEHWGSTEDWSSNLAQDVCELLEEHTERAPRISQEFGERMAHCCLGGLAEFLQSFQQRVERFHENPGVRELPPDTYISRTISLVNCGPPLRALAERLARVGPPESEPAREAAASALDRVIRLCHRILTDLLFQELQPHFSKLMRRKWLSSSEALDGIVGTLGAKALALRRMQDEPYQALVAELHRRALVEYVRPLFRGRLRCGSARTRSRVAGRLREDAAQLERLFRRLESQASWLDAVVPRLAEVLRLEDTPSIQMEVGVLVRDYPDIRQKHVATLLDIRGLRHTAARQEILAVTRDLELCEVAALSPPRDRAFFADIPVPRPPICLSLPLFLGRLTLSRLACLPWPRPPAPSPLRRPQARR", "length": 800, "header": "tr|E1B7F2-1|E1B7F2_BOVIN Isoform 1 of Exocyst complex component 3 like 2 OS=Bos taurus OX=9913 GN=EXOC3L2 PE=3 SV=3 CANONICAL=E1B7F2-1" }, "locus": { "chromosome": "18", "start_pos": 52914392, "end_pos": 52898568, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021035.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021035.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021035.4", "url": "https://www.ensembl.org/id/ENSBTAP00000021035.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:539328", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539328", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6A4S8-1", "protein_name": "Exocyst complex component 3-like 2", "gene_name": "Exoc3l2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPILKSLGVGDPKVPRAGTLPLRSSRNPFEETPTLEEEDGELGTLPNGTSCRRRATLEKLAGLAPFRLGWTSGRRAGSPGDRQVRSFLGRVLAPGIRRSSADFGLLNRLQGFRTHGDEEPAGEAARRLAFLRLGRGPKPRRASLAERLVPAGEAAPEPPPKVPEPPKIKEPLSVLEILGLIQRRELARADEHILELEAEAPAEAEAGAGRRARDVALLYEALQRELWALVRESLAAPGPGTGAVAQLGLVLLQEEEADARRGPGAARKLRAHWAEAVARAARERLEEAAAPGARGTLSGQLEALRARLLEDVAAVRGRLAPAYPAGLRAGAVYLRGYHEALAEWLGAAARRRLPLADRYALLHWHNQVYPREILGLVDVVALENGELGPLLSAGTLRGLEDECVTDVKAQTRAALLRVLQEDEEQWGSMDYRPSNLAQDVCELLEEHTERAPHISQEFVERMAYCCLGGLAEFLQSFQQRVERFHENPGVRELPSDTYISRTISMVNCGPPLRSLAERLARVGPPESEPAREASAIALDRVTRLCHRVLAELLFQELQPHFNKLMRRKWLSSSEALDGIVGTLGAQALALRRMQDEPYQVLVAELHRRALVEYVRPLLRGRLRCRSARTRSRMAGRLREDAAQLQRLFRRLESQAYWLDQVVPHLAEILQLEDTPSIQVEVGVLVRDYPDIRRKHVAALLDIRGLRNTAARQEILAVARDLELSEGGALSPSRDRAFFADIPVPRTSFCLGLPLFLGRLPVSRLARPNLACLPLRPRPPSPVRARADR", "length": 788 }, "evidence": [ { "id": "E1B7F2", "url": "https://omabrowser.org/oma/group/E1B7F2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3YUP5-1", "protein_name": "Exocyst complex component 3-like 2", "gene_name": "Exoc3l2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPILKSLGVGDPKVPRAGTLPLRSSRNPFEDTPTLEEEDAELGTLPNGTSCRRRATLEKLAGLAPFRLGWTSGRRAGSPGDGQVRSFLGRVLAPGIRRSSADFGLLNRLQGFRTHGDEEPAGEAARRLAFLRLGRGPKPRRASLAERLVPAGEAAPEPPPKVPEPPKIKEPLSVLEILGLIQRRELARADEHILELEAEAPTAEAEAGAGRRARDVALLYEALQRELWALVRESLASPGPGTGAVSQLGLVLLQEEAADARRGPGAARKLRTHWAEAVARAARERLEEAAAPGARGALAGQLEALRARLLEDVAAVRGRLAPAYPAGLRAGAVYLRGYHEALAEWLGAAARRRLPLADRYALLHWHNHVYPREILGLVDLVALENGELGPLLSAGTLRGLEDECVTDVKAQTRAALLRVLQEDEEQWGSMDYRPSNLAQDVCELLEEHTERAPHISQEFVERMAYCCLGGLAEFLQSFQQRVERFHENPGIRELPSDTYISRTISMVNCGPPLRSLAERLARVGPPESEPAREASAIALDRVTRLCHRVLAELLFQELQPHFNKLMRRKWLSSSEALDGIVGTLGAQALALRRMQDEPYQVLVAELHRRALVEYVRPLLRGRLRCRSARTRSRVAGRLREDAAQLQRLFRRLESQAYWLDQVVPHLAEILQLEDTPSIQVEVGVLVRDYPDIRRKHVAALLDIRGLRNTAARQEILAVARDLELSESGALPPSRDRAFFADIPVPRTSFCLGLPLLLGRLPVSRLARPNLACLPLRPRPPSPVRARADR", "length": 789 }, "evidence": [ { "id": "E1B7F2", "url": "https://omabrowser.org/oma/group/E1B7F2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "E1B7F2", "url": "https://www.uniprot.org/uniprotkb/E1B7F2" } ], "pmid": "" }, { "name": "exocyst localization", "id": "GO:0051601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051601", "evidence": [ { "database": "UniProtKB", "id": "E1B7F2", "url": "https://www.uniprot.org/uniprotkb/E1B7F2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "exocyst", "id": "GO:0000145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000145", "evidence": [ { "database": "UniProtKB", "id": "E1B7F2", "url": "https://www.uniprot.org/uniprotkb/E1B7F2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA-directed DNA polymerase activity", "id": "GO:0003964", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003964", "evidence": [ { "database": "UniProtKB", "id": "E1B7F2", "url": "https://www.uniprot.org/uniprotkb/E1B7F2" } ], "pmid": "" }, { "name": "SNARE binding", "id": "GO:0000149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000149", "evidence": [ { "database": "UniProtKB", "id": "E1B7F2", "url": "https://www.uniprot.org/uniprotkb/E1B7F2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7F2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 800, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7F2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7F2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.7.49", "ec_name": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "2.7.7.49", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 48, "end_pos": 50 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B835-1", "uniprot_ac": "E1B835", "uniprot_id": "E1B835_BOVIN", "mass": { "chemical_mass": 88539.0, "monoisotopic_mass": 88539.0 }, "refseq": { "ac": "XP_005225925", "name": "(E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225925" }, "gene_names": [ { "name": "C26H10orf90", "type": "recommended", "evidence": [ { "id": "E1B835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B835" } ] }, { "name": "C26H10orf90", "type": "synonym", "evidence": [ { "id": "XP_005225925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225925" } ] } ], "protein_names": [ { "name": "(E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005225925", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225925" } ] }, { "name": "Chromosome 26 C10orf90 homolog", "type": "synonym", "evidence": [ { "id": "E1B835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B835/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B835", "url": "https://www.uniprot.org/uniprotkb/E1B835" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C26H10orf90", "url": "https://www.uniprot.org/uniprotkb/E1B835", "locus": { "chromosome": "26", "start_pos": 45939063, "end_pos": 46185334, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011587", "url": "https://www.ensembl.org/id/ENSBTAG00000011587" } ] } } ], "crossref": [ { "id": "E1B835", "url": "https://alphafold.ebi.ac.uk/entry/E1B835", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011587", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011587", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614587", "url": "https://www.ncbi.nlm.nih.gov/gene/614587", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614587", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614587", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MFH4", "url": "https://www.orthodb.org/?gene=A0A3Q1MFH4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B835", "url": "https://www.orthodb.org/?gene=E1B835", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21553", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21553", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21553:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21553:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15309", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15309", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17730", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17730", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005225925", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225925", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFH4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFH4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NP32", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NP32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NP32-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NP32-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B835", "url": "https://www.uniprot.org/uniprotkb/E1B835", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B835-1", "url": "https://www.uniprot.org/uniprotkb/E1B835-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQQSGIPTKTHQKGYVARHTDTVVYPTFQIKTFSTELKNHVMVMDFVKRNWFPSQRRAKVCIIHMYQGLKTAEQTASRYEIHSRLFSSPRDHSAWERKESLSNAGLRDSQYSPHDQIALKNLQSGVPEKRSDFTEGTLASQNTKMISSIVISQLIDENKSKENGAALPVPCAYPMKPSLANRSRVTINRAFEFLPGGLGVQTPVGEPGLKTKPPPKEEKPCSGSQKGFASITITARRVGPPASTLVWEAVGDPLCVKCRARDALLGDPSALADGADPTQHHGPFTCTEFSRNSCVMGLKVPEAHAQLCEGHGYWITNVDHREDQFSPGTSRSRAGKSPLVFSSCVHLRVSQSCPNPIYYLDRSLSVPVEPPQLAGPKMHRSVLSLNLSCSSHRLTPDGVDDTENREPGSGALKPELQEGDQDLLGPRWNLGLQGSFLKENPSLGQMGFRNLEAGRCPWRGFPPSENAEAGTNQITMRKRKEDQATRCPTRGHNQANQLSIHIPGWSYTAVEPNVFSGSSEKQQEGARDIVSAPPVEWKLVRDPLPDGSSSPSNSSQSSDLSEPAESQQQRLPKPKVPLPGFLCPFQDLCASPQEEHGVQIEREAPEGDYTCCDLVVKIKECKESEHPTNPESKPAPAEPAPPEDPETHVLPEDCSKSQQGPESSLTLQEALEVRKPQFISRSQERLKKLEHMVQQRKAQRKETLAPKQSLLPVRAHKKQVTIPHPLSDNLFKPKERYISEKEMHMRSKRIYNNLPEVRKKKEEQKKRVILQSNRLRAEVFKKQLLDQLLQRNAV", "length": 794, "header": "tr|E1B835-1|E1B835_BOVIN Isoform 1 of Chromosome 26 C10orf90 homolog OS=Bos taurus OX=9913 GN=C26H10orf90 PE=4 SV=3 CANONICAL=E1B835-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MFH4-1", "url": "https://www.uniprot.org/uniprotkb/E1B835/entry#A0A3Q1MFH4-1", "sequence": { "sequence": "MSLKHQWNMIKLSEEGLRDSQYSPHDQIALKNLQSGVPEKRSDFTEGTLASQNTKMISSIVISQLIDENKSKENGAALPVPCAYPMKPSLANRSRVTINRAFEFLPGGLGVQTPVGEPGLKTKPPPKEEKPCSGSQKGFASITITARRVGPPASTLVWEAVGDPLCVKCRARDALLGDPSALADGADPTQHHGPFTCTEFSRNSCVMGLKVPEAHAQLCEGHGYWITNVDHREDQFSPGTSRSRAGKSPLVFSSCVHLRVSQSCPNPIYYLDRSLSVPVEPPQLAGPKMHRSVLSLNLSCSSHRLTPDGVDDTENREPGSGALKPELQEGDQDLLGPRWNLGLQGSFLKENPSLGQMGFRNLEAGRCPWRGFPPSENAEAGTNQITMRKRKEDQATRCPTRGHNQANQLSIHIPGWSYTAVEPNVFSGSSEKQQEGARDIVSAPPVEWKLVRDPLPDGSSSPSNSSQSSDLSEPAESQQQRLPKPKVPLPGFLCPFQDLCASPQEEHGVQIEREAPEGDYTCCDLVVKIKECKESEHPTNPESKPAPAEPAPPEDPETHVLPEDCSKSQQGPESSLTLQEALEVRKPQFISRSQERLKKLEHMVQQRKAQRKETLAPKQSLLPVRAHKKQVTIPHPLSDNLFKPKERYISEKEMHMRSKRIYNNLPEVRKKKEEQKKRVILQSNRLRAEVFKKQLLDQLLQRNAV", "length": 705, "header": "tr|A0A3Q1MFH4-1|E1B835_BOVIN Computationally mapped isoform of Chromosome 26 C10orf90 homolog OS=Bos taurus OX=9913 GN=C26H10orf90 PE=4 SV=2 CANONICAL=E1B835-1" }, "locus": { "chromosome": "26", "start_pos": 46031845, "end_pos": 45939165, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067090.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067090.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069275.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069275.2" } ] } }, { "isoform_ac": "A0ABI0NP32-1", "url": "https://www.uniprot.org/uniprotkb/E1B835/entry#A0ABI0NP32-1", "sequence": { "sequence": "MISSIVISQLIDENKSKENGAALPVPCAYPMKPSLANRSRVTINRAFEFLPGGLGVQTPVGEPGLKTKPPPKEEKPCSGSQKGFASITITARRVGPPASTLVWEAVGDPLCVKCRARDALLGDPSALADGADPTQHHGPFTCTEFSRNSCVMGLKVPEAHAQLCEGHGYWITNVDHREDQFSPGTSRSRAGKSPLVFSSCVHLRVSQSCPNPIYYLDRSLSVPVEPPQLAGPKMHRSVLSLNLSCSSHRLTPDGVDDTENREPGSGALKPELQEGDQDLLGPRWNLGLQGSFLKENPSLGQMGFRNLEAGRCPWRGFPPSENAEAGTNQITMRKRKEDQATRCPTRGHNQANQLSIHIPGWSYTAEPNVFSGSSEKQQEGARDIVSAPPVEWKLVRDPLPDGSSSPSNSSQSSDLSEPAESQQQRLPKPKVPLPGFLCPFQDLCASPQEEHGVQIEREAPEGDYTCCDLVVKIKECKESEHPTNPESKPAPAEPAPPEDPETHVLPEDCSKSQQGPESSLTLQEALEVRKPQFISRSQERLKKLEHMVQQRKAQRKETLAPKQSLLPVRAHKKQVTIPHPLSDNLFKPKERYISEKEMHMRSKRIYNNLPEVRKKKEEQKKRVILQSNRLRAEVFKKQLLDQLLQRNAV", "length": 649, "header": "tr|A0ABI0NP32-1|A0ABI0NP32_BOVIN Computationally mapped isoform of Chromosome 26 C10orf90 homolog OS=Bos taurus OX=9913 GN=C26H10orf90 PE=4 SV=1 CANONICAL=E1B835-1" }, "locus": { "chromosome": "26", "start_pos": 46013001, "end_pos": 45939165, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147090.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147090.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107582.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107582.1" } ] } }, { "isoform_ac": "E1B835-1", "url": "https://www.uniprot.org/uniprotkb/E1B835/entry#E1B835-1", "sequence": { "sequence": "MQQSGIPTKTHQKGYVARHTDTVVYPTFQIKTFSTELKNHVMVMDFVKRNWFPSQRRAKVCIIHMYQGLKTAEQTASRYEIHSRLFSSPRDHSAWERKESLSNAGLRDSQYSPHDQIALKNLQSGVPEKRSDFTEGTLASQNTKMISSIVISQLIDENKSKENGAALPVPCAYPMKPSLANRSRVTINRAFEFLPGGLGVQTPVGEPGLKTKPPPKEEKPCSGSQKGFASITITARRVGPPASTLVWEAVGDPLCVKCRARDALLGDPSALADGADPTQHHGPFTCTEFSRNSCVMGLKVPEAHAQLCEGHGYWITNVDHREDQFSPGTSRSRAGKSPLVFSSCVHLRVSQSCPNPIYYLDRSLSVPVEPPQLAGPKMHRSVLSLNLSCSSHRLTPDGVDDTENREPGSGALKPELQEGDQDLLGPRWNLGLQGSFLKENPSLGQMGFRNLEAGRCPWRGFPPSENAEAGTNQITMRKRKEDQATRCPTRGHNQANQLSIHIPGWSYTAVEPNVFSGSSEKQQEGARDIVSAPPVEWKLVRDPLPDGSSSPSNSSQSSDLSEPAESQQQRLPKPKVPLPGFLCPFQDLCASPQEEHGVQIEREAPEGDYTCCDLVVKIKECKESEHPTNPESKPAPAEPAPPEDPETHVLPEDCSKSQQGPESSLTLQEALEVRKPQFISRSQERLKKLEHMVQQRKAQRKETLAPKQSLLPVRAHKKQVTIPHPLSDNLFKPKERYISEKEMHMRSKRIYNNLPEVRKKKEEQKKRVILQSNRLRAEVFKKQLLDQLLQRNAV", "length": 794, "header": "tr|E1B835-1|E1B835_BOVIN Isoform 1 of Chromosome 26 C10orf90 homolog OS=Bos taurus OX=9913 GN=C26H10orf90 PE=4 SV=3 CANONICAL=E1B835-1" }, "locus": { "chromosome": "26", "start_pos": 46185135, "end_pos": 45939165, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032726.5", "url": "https://www.ensembl.org/id/ENSBTAT00000032726.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032655.5", "url": "https://www.ensembl.org/id/ENSBTAP00000032655.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614587", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614587", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "E1B835", "url": "https://www.uniprot.org/uniprotkb/E1B835" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B835", "url": "https://www.uniprot.org/uniprotkb/E1B835" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "E1B835", "url": "https://www.uniprot.org/uniprotkb/E1B835" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "E1B835", "url": "https://www.uniprot.org/uniprotkb/E1B835" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of centriole replication", "id": "GO:0046599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046599", "evidence": [ { "database": "UniProtKB", "id": "E1B835", "url": "https://www.uniprot.org/uniprotkb/E1B835" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" }, { "start_pos": 181, "end_pos": 183, "annotation": "n_glycosylation_sequon" }, { "start_pos": 386, "end_pos": 388, "annotation": "n_glycosylation_sequon" }, { "start_pos": 553, "end_pos": 555, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B835-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 794, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B835-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B835" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B835" }, { "id": "PF15309", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15309" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ALMS motif", "eco_id": "ECO_0000259", "start_pos": 664, "end_pos": 792, "start_aa": "Ser", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B835" }, { "id": "PF17730", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17730" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Centrosomal protein C10orf90 N-terminal", "eco_id": "ECO_0000259", "start_pos": 149, "end_pos": 658, "start_aa": "Ile", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 158, "end_pos": 160 }, { "start_pos": 181, "end_pos": 183 }, { "start_pos": 386, "end_pos": 388 }, { "start_pos": 553, "end_pos": 555 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B6Y2-1", "uniprot_ac": "E1B6Y2", "uniprot_id": "E1B6Y2_BOVIN", "mass": { "chemical_mass": 65566.0, "monoisotopic_mass": 65566.0 }, "refseq": { "ac": "XP_002694814", "name": "zinc finger protein 276 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694814" }, "gene_names": [ { "name": "ZNF276", "type": "recommended", "evidence": [ { "id": "E1B6Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2" } ] }, { "name": "ZNF276", "type": "synonym", "evidence": [ { "id": "XP_002694814", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694814" } ] } ], "protein_names": [ { "name": "Zinc finger protein 276", "type": "recommended", "evidence": [ { "id": "E1B6Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 276 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002694814", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694814" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y2", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0A3Q1MFH7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFH7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B6Y2", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF276", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2", "locus": { "chromosome": "18", "start_pos": 14608124, "end_pos": 14592494, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001904", "url": "https://www.ensembl.org/id/ENSBTAG00000001904" } ] } } ], "crossref": [ { "id": "E1B6Y2", "url": "https://alphafold.ebi.ac.uk/entry/E1B6Y2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001904", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001904", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513761", "url": "https://www.ncbi.nlm.nih.gov/gene/513761", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012934", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012934", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513761", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513761", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LAVKWAW", "url": "https://omabrowser.org/oma/group/LAVKWAW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MFH7", "url": "https://www.orthodb.org/?gene=A0A3Q1MFH7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B6Y2", "url": "https://www.orthodb.org/?gene=E1B6Y2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24379", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24379", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24379:SF121", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24379:SF121", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07776", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07776", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002694814", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694814", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFH7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFH7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFH7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFH7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B6Y2", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B6Y2-1", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRDRLGRFLSPAASRQRGSSGRGSCGGGRVRGRPARSGPDVAEAAAVVAARLGWGPARPCGDAGEDGADEAGTARALAMGHCRLCHGKFSSRSLRSISGRAPGESSERPPPGDRVFIRDFQRLLGVAVHQDPALSQFICKNCHAQFYQCHGLLTSFLQRVNVPPTGRRKPCAKVGVQPRMGPEEGACVVDLIASSPQGLRGLVGWVHRHAAGCGALPSLQRTLSSEYCGVIRAMWGCDQGHDYTMDADSSCGALLLDSALGVKWTWDKDSAPRLPQHRGFNPTGAAPQSSQGKAAAAGAETETLPSMDTSRLPSDGDPVGPGPGPPSQPSLPPGGAPGQLGEKQVPSPTSDDRVKDEFSDLSEGDFLSEDENDKKQNTQSSDESFEPYPGKKVSGRKSESKEAKKSEEPKIRKKPGPKPGWKGKPRCEREELPTIYKCPHQGCTAVYRGADGMKKHVKEHHEEVRERPCPHPGCNKVFMIDRYLQRHVKLIHTEVRNYICDECGQTFKQRKHLLVHQMRHSGAKPLQCEVCGFQCRQRASLKYHMTKHKAETELDFACDQCGRRFEKAHNLNVHMSMVHPLTQAPEAPPRPAAGQVVKAEPT", "length": 603, "header": "tr|E1B6Y2-1|E1B6Y2_BOVIN Isoform 1 of Zinc finger protein 276 OS=Bos taurus OX=9913 GN=ZNF276 PE=4 SV=1 CANONICAL=E1B6Y2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MFH7-1", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2/entry#A0A3Q1MFH7-1", "sequence": { "sequence": "MGHCRLCHGKFSSRSLRSISGRAPGESSERPPPGDRVFIRDFQRLLGVAVHQDPALSQFICKNCHAQFYQCHGLLTSFLQRVNVPPTGRRKPCAKVGVQPRMGPEEGACVVDLIASSPQGLRGLVGWVHRHAAGCGALPSLQRTLSSEYCGVIRAMWGCDQGHDYTMDADSSCGALLLDSALGVKWTWDKDSAPRLPQHRGFNPTGAAPQSSQGKAAAAGAETETLPSMDTSRLPSDGDPVGPGPGPPSQPSLPPGGAPGQLGEKQVPSPTSDDRVKDEFSDLSEGDFLSEDENDKKQNTQSSDESFEPYPGKKVSGRKSESKEAKKSEEPKIRKKPGPKPGWKGKPRCEREELPTIYKCPHQGCTAVYRGADGMKKHVKEHHEEVRERPCPHPGCNKVFMIDRYLQRHVKLIHTEVRNYICDECGQTFKQRKHLLVHQMRHSGAKPLQCEVCGFQCRQRASLKYHMTKHKAETELDFACDQCGRRFEKAHNLNVHMSMVHPLTQAPEAPPRPAAGQVVKAEPT", "length": 524, "header": "tr|A0A3Q1MFH7-1|E1B6Y2_BOVIN Computationally mapped isoform of Zinc finger protein 276 OS=Bos taurus OX=9913 GN=ZNF276 PE=4 SV=3 CANONICAL=E1B6Y2-1" }, "locus": { "chromosome": "18", "start_pos": 14607120, "end_pos": 14597547, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079629.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079629.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072960.3", "url": "https://www.ensembl.org/id/ENSBTAP00000072960.3" } ] } }, { "isoform_ac": "E1B6Y2-1", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2/entry#E1B6Y2-1", "sequence": { "sequence": "MKRDRLGRFLSPAASRQRGSSGRGSCGGGRVRGRPARSGPDVAEAAAVVAARLGWGPARPCGDAGEDGADEAGTARALAMGHCRLCHGKFSSRSLRSISGRAPGESSERPPPGDRVFIRDFQRLLGVAVHQDPALSQFICKNCHAQFYQCHGLLTSFLQRVNVPPTGRRKPCAKVGVQPRMGPEEGACVVDLIASSPQGLRGLVGWVHRHAAGCGALPSLQRTLSSEYCGVIRAMWGCDQGHDYTMDADSSCGALLLDSALGVKWTWDKDSAPRLPQHRGFNPTGAAPQSSQGKAAAAGAETETLPSMDTSRLPSDGDPVGPGPGPPSQPSLPPGGAPGQLGEKQVPSPTSDDRVKDEFSDLSEGDFLSEDENDKKQNTQSSDESFEPYPGKKVSGRKSESKEAKKSEEPKIRKKPGPKPGWKGKPRCEREELPTIYKCPHQGCTAVYRGADGMKKHVKEHHEEVRERPCPHPGCNKVFMIDRYLQRHVKLIHTEVRNYICDECGQTFKQRKHLLVHQMRHSGAKPLQCEVCGFQCRQRASLKYHMTKHKAETELDFACDQCGRRFEKAHNLNVHMSMVHPLTQAPEAPPRPAAGQVVKAEPT", "length": 603, "header": "tr|E1B6Y2-1|E1B6Y2_BOVIN Isoform 1 of Zinc finger protein 276 OS=Bos taurus OX=9913 GN=ZNF276 PE=4 SV=1 CANONICAL=E1B6Y2-1" }, "locus": { "chromosome": "18", "start_pos": 14607120, "end_pos": 14593024, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002476.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002476.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002476.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002476.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513761", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513761", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061IC99-1", "protein_name": "Zinc finger protein 276", "gene_name": "Znf276", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKRDRLGRFLSPGTARQRGSSGGSCGSGRTRGRPSRTGAASADGAAALAAAQLSWGSTRSCGDTGEDGTDEAGAGRTLAMGHCRLCHGKFSSRSLRSISDRVPGETSERLSPGERVFIRDFQRLLGVAVHQDPALPQFVCKNCYTQFYQCHSLLRSFLQRVNVSPAGQRKPCTKVGVQPPTVAEEGACMADLITSSPRCLHSLVGWVHEHAANCGSLPSLQRTLSSEYCGIIQAVWGCDQGHDFTMDTDSSCRALLLDSALAVKWAWGKEMSPRLSQSSELNTTGAASQLCQARGTQVGSETKTPPSVDVALLHSHGDSVGPGIGPYTQPNLAPSEAPGQLGEKQVPSSTSDDRVKDEFSDLSEGDFLSEDENDKKQNPQSSDESFEPYPEKKVSGKKSESKEAKKPEEPKIRKKPGPKPGWKKKLRCEREELPTIYKCPYQGCTAVYRGADGMKKHIKEHHEEVRERPCPHPGCNKVFMIDRYLQRHVKLIHTEVRNYICDECGQTFKQRKHLLVHQMRHSGAKPLQCEICGFQCRQRASLKYHMTKHKAETELDFACDQCGRRFEKAHNLNVHMSMVHPLTQTQDKVLPLEAEPPPGPLSLSGTMEGQAVKPEPT", "length": 617 }, "evidence": [ { "id": "E1B6Y2", "url": "https://omabrowser.org/oma/group/E1B6Y2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8M9PUR8-1", "protein_name": "Zinc finger protein 276", "gene_name": "znf276", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRRRGTRTSRRETRDHSSGRSSSSFCRLCHGKFSRRRLLQAFAQLQGEACGGVYPLFCADFQQLLGIRMERDPALSQFICTGCHAQFYRCHSILLQFRSRVNLTPPTAHSYNDAVSSRSGAEHSSSQEDISLIRSQMPWDRRCLLSLVSWAHGHAEGCSSCPGLQEVLEGPCGGALRAVWGCGDGHSYVMDSGAAASTHTTEDHTDEHAQPTHQQGAALSGSDPLRSAEPQNHSDTHDTQCSEQTDASLTPAPAEDADSELSDRNMLSDEECEEQRKSGSSEDSDPHTDKRSSKRKETKTPEPKTRRKPGPKPGWKNSSKSEREELPTIYKCPHQGCTAVYRGADGMKKHIKEHHEEVRERPCPHPGCNKVFMIDRYLQRHVKLIHTEVRNYICDQCGQTFKQRKHLSVHQMRHSGAKPLQCEVCGFQCRQRASLKYHMTKHKAEADLEFACVICGKRFEKAHNLNVHMSMVHPLMQSAGATVPADPPLTHS", "length": 492 }, "evidence": [ { "id": "E1B6Y2", "url": "https://omabrowser.org/oma/group/E1B6Y2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1LN08-1", "protein_name": "Zinc finger protein 276", "gene_name": "Zfp276", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKRDRLGRFLSPGIARQRGSSGSSCGSGRTRGRPSRTGGSSADGAAPQLSWGSTRSCGDTGEDGTDEAGAGRTLTMGHCRLCHGKFSSRSLRSISERVPGETSERLSPGERVFIRDFQRLLGVAVHQDPALPQFVCKNCYTQFYQCHSLLRSFLQRVNVSPAGQRKPCTKVGVQPPTVAEEGACMADLITSSPQCLHGLVGWVHEHAVNCGCLPSLQRTLSSEYCGVIQAVWGCDQGHDFTMDTDSGCRALLLDSALAVKWGKELAPRLAQSSASDPTGAASQLCQARETQVGSETKTLPSVDVALLHSHGDSVGPGLSPYIQPNLAPSEAPGQLGEKQVPSSTSDDRVKDEFSDLSEGDVLSEDDSDKKQTPQSSDESFEPYPEKKVSGKKSEGKEAKRPEEPKIRKKPGPKPGWKKKLRCEREELPTIYKCPYQGCTAVYRGADGMKKHIKEHHEEVRERPCPHPGCNKVFMIDRYLQRHVKLIHTEVRNYICDECGQTFKQRKHLLVHQMRHSGAKPLQCEVCGFQCRQRASLKYHMTKHKAETELDFACDQCGRRFEKAHNLNVHMSMVHPLTQTQALPLEAEPPPGPLSLAGTVEGQAVKPEPT", "length": 609 }, "evidence": [ { "id": "E1B6Y2", "url": "https://omabrowser.org/oma/group/E1B6Y2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NLX3-1", "protein_name": "Zinc finger protein 276", "gene_name": "ZNF276", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKRDRRGRFLAAAGGPAAASPEPRKRPAARGSAEGEAGPEPTAGWAPVAAEDSAWARPGGAAEAGIGRALSTGYCRLCHGKFSSRSLRNAFGKVPVMGENSEKQRRVDQVFFTDFQRLVGVAVRQDPALPQFVCKKCHAQFYKCRSVLRTFIQRVNASPTGHVKSKGKSGAAPAQPGVEGGASCLVDLITSSPQCLHSLVTWAHAHAGGCQSVPSLQSVLSSEYCGIIRAVWGCGDGHDYIMDTDSDCSTVLVDNALAVKREWNKSVAQRLTDNGADNAEAVSAPKPQHAPVRTTPCQQPTNKGTTTVPLKLENEPSQNRDSSHSQLDSTASLQEKALPQPVSPLSSTTGQLSGKQVLSATSDERVKDEFSDLSEGDFLSDDEMEKRNVQSSDDSFEPYPEKKVSSKKSDSKEAKKAEEPKVRKKPGPKPGWKKKIKCEREELPTIYKCPYQGCTAVYRGADGMKKHIKEHHEEVRERPCPHPGCNKVFMIDRYLQRHVKLIHTEVRNYICDECGQTFKQRKHLSVHQMRHSGAKPLQCEICGFQCRQRASLKYHMTKHKAETELEFACDQCGKRFEKAHNLNVHMSMVHPLTQTQDKTKPLESESILLLNTSGTSESQAVKPEVTAQQEPT", "length": 632 }, "evidence": [ { "id": "E1B6Y2", "url": "https://omabrowser.org/oma/group/E1B6Y2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8CE64-1", "protein_name": "Zinc finger protein 276", "gene_name": "Znf276", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKRDRLGRFLSPGIARQRGGSGGGCGSGRTRGRPSRSGGTSADGAAAQLSWGSMTRSCGDTGDDGTDEAGAGRTLAMGHCRLCHGKFSSRSLRSISDRVPGETSERLSPGERVFIRDFQRLLGVAVHQDPALPQSVCKNCYTQFYQCHSLLRTFLQRVNVSPAGQRKPCTKVGVQPTTVAEEGACVADLIASSPRCLHGLVGWVHEHAVSCGSLPSLQRTLSSEYCGIIQAVWGCDQGHDFTMDTASSCRALFLDSALAVKWAWGKDLSPRLAQNSESNPTGAASRLCQARETQVGSETKTLPSVDVALLHSHGDSVGPGLGPCTQPHLAPSEAPGQLGETQVPSSTSDDRVKDEFSDLSEGDFLSEDESDKKQTPQSSDESFEPYPEKKVSGKKSEGREAKRPEEPKIRKKPGPKPGWKKKLRCEREELPTIYKCPYQGCTAVYRGADGMKKHIKEHHEEVRERPCPHPGCNKVFMIDRYLQRHVKLIHTEVRNYICDECGQTFKQRKHLLVHQMRHSGAKPLQCEVCGFQCRQRASLKYHMTKHKAETELDFACDQCGRRFEKAHNLNVHMSMVHPLTQAQDRALPLEAEPPPGPLSPSGTMEGQAVKPEPT", "length": 614 }, "evidence": [ { "id": "E1B6Y2", "url": "https://omabrowser.org/oma/group/E1B6Y2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N554-1", "protein_name": "Zinc finger protein 276", "gene_name": "ZNF276", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKRDRLGRFLSPGSSRQCGASDGGGGVSRTRGRPSLSGGPRVDGATARRAWGPVGSCGDAGEDGADEAGAGRALAMGHCRLCHGKFSSRSLRSISERAPGASMERPSAEERVLVRDFQRLLGVAVRQDPTLSPFVCKSCHAQFYQCHSLLKSFLQRVNASPAGRRKPCAKVGAQPPTGAEEGACLVDLITSSPQCLHGLVGWVHGHAASCGALPHLQRTLSSEYCGVIQVVWGCDQGHDYTMDTSSSCKAFLLDSALAVKWPWDKETAPRLPQHRGWNPGDAPQTSQGRGTGTPVGAETKTLPSTDVAQPPSDSDAVGPRSGFPPQPSLPLCRAPGQLGEKQLPSSTSDDRVKDEFSDLSEGDVLSEDENDKKQNAQSSDESFEPYPERKVSGKKSESKEAKKSEEPRIRKKPGPKPGWKKKLRCEREELPTIYKCPYQGCTAVYRGADGMKKHIKEHHEEVRERPCPHPGCNKVFMIDRYLQRHVKLIHTEVRNYICDECGQTFKQRKHLLVHQMRHSGAKPLQCEVCGFQCRQRASLKYHMTKHKAETELDFACDQCGRRFEKAHNLNVHMSMVHPLTQTQDKALPLEAEPPPGPPSPSVTTEGQAVKPEPT", "length": 614 }, "evidence": [ { "id": "E1B6Y2", "url": "https://omabrowser.org/oma/group/E1B6Y2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y2", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y2", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y2", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y2", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y2", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y2", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y2", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B6Y2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 603, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B6Y2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B6Y2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B6Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 468, "end_pos": 498, "start_aa": "Arg", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B6Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2" }, { "id": "PS51915", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51915" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ZAD", "eco_id": "ECO_0000259", "start_pos": 81, "end_pos": 167, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "E1B6Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2#function" }, { "id": "E1B6Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2" }, { "id": "PRU01263", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01263" } ], "binding_site_uniprot": 140, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 140, "end_pos": 140, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B6Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2#function" }, { "id": "E1B6Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2" }, { "id": "PRU01263", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01263" } ], "binding_site_uniprot": 143, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 143, "end_pos": 143, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1MFH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFH7#function" }, { "id": "A0A3Q1MFH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFH7" }, { "id": "PRU01263", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01263" } ], "binding_site_uniprot": 4, "amino_acid": "Asp", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 4, "end_pos": 4, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1MFH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFH7#function" }, { "id": "A0A3Q1MFH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFH7" }, { "id": "PRU01263", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01263" } ], "binding_site_uniprot": 61, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 61, "end_pos": 61, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1MFH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFH7#function" }, { "id": "A0A3Q1MFH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFH7" }, { "id": "PRU01263", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01263" } ], "binding_site_uniprot": 64, "amino_acid": "Ala", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 64, "end_pos": 64, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0A3Q1MFH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFH7#function" }, { "id": "A0A3Q1MFH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFH7" }, { "id": "PRU01263", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01263" } ], "binding_site_uniprot": 7, "amino_acid": "Gly", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 7, "end_pos": 7, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B6Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2#function" }, { "id": "E1B6Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2" }, { "id": "PRU01263", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01263" } ], "binding_site_uniprot": 83, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 83, "end_pos": 83, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B6Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2#function" }, { "id": "E1B6Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6Y2" }, { "id": "PRU01263", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01263" } ], "binding_site_uniprot": 86, "amino_acid": "Cys", "chebi_lig_id": "CHEBI_29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 86, "end_pos": 86, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B7I8-1", "uniprot_ac": "E1B7I8", "uniprot_id": "E1B7I8_BOVIN", "mass": { "chemical_mass": 90654.0, "monoisotopic_mass": 90654.0 }, "refseq": { "ac": "XP_010817485", "name": "telomere length regulation protein TEL2 homolog isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010817485" }, "gene_names": [ { "name": "TELO2", "type": "recommended", "evidence": [ { "id": "E1B7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7I8" } ] }, { "name": "TELO2", "type": "synonym", "evidence": [ { "id": "XP_010817485", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010817485" } ] } ], "protein_names": [ { "name": "Telomere length regulation protein TEL2 homolog", "type": "recommended", "evidence": [ { "id": "E1B7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7I8/entry#names_and_taxonomy" } ] }, { "name": "telomere length regulation protein TEL2 homolog isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010817485", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010817485" } ] } ], "function": [ { "annotation": "Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation.", "evidence": [ { "database": "UniProtKB", "id": "E1B7I8", "url": "https://www.uniprot.org/uniprotkb/E1B7I8#function" }, { "database": "UniProtKB", "id": "ARBA00053387", "url": "https://www.uniprot.org/uniprotkb/ARBA00053387#function" }, { "database": "UniProtKB", "id": "A0A3Q1MKF3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKF3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7I8", "url": "https://www.uniprot.org/uniprotkb/E1B7I8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TELO2", "url": "https://www.uniprot.org/uniprotkb/E1B7I8", "locus": { "chromosome": "25", "start_pos": 1185007, "end_pos": 1173828, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019086", "url": "https://www.ensembl.org/id/ENSBTAG00000019086" } ] } } ], "crossref": [ { "id": "E1B7I8", "url": "https://alphafold.ebi.ac.uk/entry/E1B7I8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019086", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019086", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "526097", "url": "https://www.ncbi.nlm.nih.gov/gene/526097", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038528", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038528", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057348", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057348", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526097", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526097", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FYPQNYF", "url": "https://omabrowser.org/oma/group/FYPQNYF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MKF3", "url": "https://www.orthodb.org/?gene=A0A3Q1MKF3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B7I8", "url": "https://www.orthodb.org/?gene=E1B7I8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15830", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15830", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15830:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15830:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10193", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10193", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25320", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25320", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010817485", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010817485", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MKF3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKF3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MKF3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKF3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7I8", "url": "https://www.uniprot.org/uniprotkb/E1B7I8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7I8-1", "url": "https://www.uniprot.org/uniprotkb/E1B7I8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPVASAVRLAVQEAVHILSSSEDGGHIISTLQSLRRYLGETETQAPPEEQEEFSRTHFSTILRCLVGKLSPDWLDLLPDGQLEELWASFFLEGPADQAFLVLMESIEGAASPSFRLMKMARLLARFLSAGRMAAVMEGQCGQQAGPASRLLQETLLTRVVGLPDHLGNRLQRETLAAFFPQNYFPLLGEEVLRVLQAVVDSLRGGLDCSVSFLSQVLGKACVHGRQKEILDVLVPRLTVLTQGNCLWQRVCWRLVECVPDRAMEAVLKGLVEAAPGPEVLSRLLGNLVTKSKKAQFVMTQKLLFLQYSCSMPMLQSLLGYLAMDSQRRPLLVQALKELLETWGSSSAIRHTPLEQQRYVSKALLICLTHLGEAELRASRDELLASLMEGVKSRLDSSLPPVRRLGMIVAEVASARLHPEGPPLKFQYEEDELTREMLALAVPRPAADGPSEAGPPVAPVSGEFPDQETVDSGGPQAGWEGSDSELDSDDELVPYDMSGDGEQRGSKTPAYVRDCLEALTASEDWERWEEALRALEGLVLKSPAATREVSLELAKVLLHLEEKTAVAGFERLRQRALVAVTVTDPARVAEYLAVQFYALNYSLRQRMDILDVLALAAQELSRPGRLGKAAQRGSPGPGSQPSGAAVPAWKAVVEERVRRKTRRFCKQGSTGRAAAAGPNEFNAVAGYFFFPLLQRFDRPVVTFDLLGDDQLVLGRLAHTLGALMYLAVNTAVAVPMGKALLEFVWALRFHGDAYVRRGLLSAVSSVLLSVPAEWLLADLPDELLEARSWLADVAEQDADEDCRLLAVKALLLLEKLRDRLLPLSSP", "length": 826, "header": "tr|E1B7I8-1|E1B7I8_BOVIN Isoform 1 of Telomere length regulation protein TEL2 homolog OS=Bos taurus OX=9913 GN=TELO2 PE=3 SV=4 CANONICAL=E1B7I8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MKF3-1", "url": "https://www.uniprot.org/uniprotkb/E1B7I8/entry#A0A3Q1MKF3-1", "sequence": { "sequence": "MDPVASAVRLAVQEAVHILSSSEDGGHIISTLQSLRRYLGETETQAPPEEQEEFSRTHFSTILRCLVGKLSPDWLDLLPDGQLEELWASFFLEGPADQAFLVLMESIEGAASPSFRLMKMARLLARFLSAGRMAAVMEGQCGQQAGPASRLLQETLLTRVVGLPDHLGNRLQRETLAAFFPQNYFPLLGEEVLRVLQAVVDSLRGGLDCSVSFLSQVLGKACVHGRQKEILDVLVPRLTVLTQGNCLWQRVCWRLVECVPDRAMEAVLKGLVEAAPGPEVLSRLLGNLVTKSKKAQFVMTQKLLFLQYSCSMPMLQSLLGYLAMDSQRRPLLVQALKELLETWGSSSAIRHTPLEQQRYVSKALLICLTHLGEAELRASRDELLASLMEGVKSRLDSSLPPVRRLGMIVAEVASARLHPEGPPLKFQYEEDELTREMLALAVPRPAADGPSEAGDDELVPYDMSGDGEQRGSKTPAYVRDCLEALTASEDWERWEEALRALEGLVLKSPAATREVSLELAKVLLHLEEKTAVAGFERLRQRALVAVTVTDPARVAEYLAVQFYALNYSLRQRMDILDVLALAAQELSRPGRLGKAAQRGSPGPGSQPSGAAVPAWKAVVEERVRRKTRRFCKGSTGRAAAAGPNEFNAVAGYFFFPLLQRFDRPVVTFDLLGDDQLVLGRLAHTLGALMYLAVNTAVAVPMGKALLEFVWALRFHGDAYVRRGLLSAVSSVLLSVPAEWLLADLPDELLEARSWLADVAEQDADEDCRLLAVKALLLLEKLRDRLLPLSSP", "length": 791, "header": "tr|A0A3Q1MKF3-1|E1B7I8_BOVIN Computationally mapped isoform of Telomere length regulation protein TEL2 homolog OS=Bos taurus OX=9913 GN=TELO2 PE=3 SV=1 CANONICAL=E1B7I8-1" }, "locus": { "chromosome": "25", "start_pos": 1184003, "end_pos": 1174899, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084520.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084520.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072007.1", "url": "https://www.ensembl.org/id/ENSBTAP00000072007.1" } ] } }, { "isoform_ac": "E1B7I8-1", "url": "https://www.uniprot.org/uniprotkb/E1B7I8/entry#E1B7I8-1", "sequence": { "sequence": "MDPVASAVRLAVQEAVHILSSSEDGGHIISTLQSLRRYLGETETQAPPEEQEEFSRTHFSTILRCLVGKLSPDWLDLLPDGQLEELWASFFLEGPADQAFLVLMESIEGAASPSFRLMKMARLLARFLSAGRMAAVMEGQCGQQAGPASRLLQETLLTRVVGLPDHLGNRLQRETLAAFFPQNYFPLLGEEVLRVLQAVVDSLRGGLDCSVSFLSQVLGKACVHGRQKEILDVLVPRLTVLTQGNCLWQRVCWRLVECVPDRAMEAVLKGLVEAAPGPEVLSRLLGNLVTKSKKAQFVMTQKLLFLQYSCSMPMLQSLLGYLAMDSQRRPLLVQALKELLETWGSSSAIRHTPLEQQRYVSKALLICLTHLGEAELRASRDELLASLMEGVKSRLDSSLPPVRRLGMIVAEVASARLHPEGPPLKFQYEEDELTREMLALAVPRPAADGPSEAGPPVAPVSGEFPDQETVDSGGPQAGWEGSDSELDSDDELVPYDMSGDGEQRGSKTPAYVRDCLEALTASEDWERWEEALRALEGLVLKSPAATREVSLELAKVLLHLEEKTAVAGFERLRQRALVAVTVTDPARVAEYLAVQFYALNYSLRQRMDILDVLALAAQELSRPGRLGKAAQRGSPGPGSQPSGAAVPAWKAVVEERVRRKTRRFCKQGSTGRAAAAGPNEFNAVAGYFFFPLLQRFDRPVVTFDLLGDDQLVLGRLAHTLGALMYLAVNTAVAVPMGKALLEFVWALRFHGDAYVRRGLLSAVSSVLLSVPAEWLLADLPDELLEARSWLADVAEQDADEDCRLLAVKALLLLEKLRDRLLPLSSP", "length": 826, "header": "tr|E1B7I8-1|E1B7I8_BOVIN Isoform 1 of Telomere length regulation protein TEL2 homolog OS=Bos taurus OX=9913 GN=TELO2 PE=3 SV=4 CANONICAL=E1B7I8-1" }, "locus": { "chromosome": "25", "start_pos": 1184003, "end_pos": 1174899, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025412.8", "url": "https://www.ensembl.org/id/ENSBTAT00000025412.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025412.7", "url": "https://www.ensembl.org/id/ENSBTAP00000025412.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:526097", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526097", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1I9LMG5-1", "protein_name": "Embryo defective 2423", "gene_name": "EMB2423", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAEGTKQERTLENNLLHKVGEAVSAISDAKHVDQVISAIHSVAVLLFPVDPSLFSGSIGDKYRERVCSSVVPSADERNEWLETFYRGVAFPTFARVLLLDVASDWLSCFPISVQKHLYDKFFLDGSVIEVVQVLVPFLHHVGDGGVNANSVQTNVERLLILCLLENDGVLKITKEIGNIYQGHNSSNGSLKPLLSRLSQILTSIPDKARLKSPPLLSSNLYFKHITNQLLQILDDRASCTEANCTVIVLSFVGEVFSRICRRGLSDLLLSEVTPHVLAQVRRLLNSKIGAIEVDTFQLDPTTRIWSKTMEAVTDPYAVEKMAEQLLHQLYAEHPSDVEAFWTIWTLFHRNVIHQASVRSIFVDKFLLWKVFPIRCLRWILQFSVLECPPVTNTLAKGDVTQGLLETTQRLASVWSKREFLQSVQLEQQAYITAALGLCLENMSREELDRTKDVMHSILQGVSCRLENPGDLVRKMASSIAFMFSKVIDPKNPLYLDDSITDNAIDWEFGLQTASITNTMENGDGENKRSASLTEVNESSRRNKQKENRKSKNISAFVLADPNEIVDLATLNCDTESDKDDGDDDASVSSDNSSVTSLEPYDLMDDDKDLGKQFTHLVDVVGALRKTDDADGVEKAIYVAEKLVRASPDELTHIAGDLARTLVQVRCSDIAIEGEEDSAEEKRQRALIALLVTRPFESLETLNNILYSPNVDVSQRIMILDVMAEAARELANSKTLKPKHEARGPLISNISDPQPWYLPSNASTPWKKVSETGSFHLNWANRFERELQSKPGQTKKGKSRRWSLKSADRDQNSTDWSQNRFPLYAAAFMLPAMKEFDKKRHGVDLLGRDFVVLGKLVHMLGVCMQCASMHPEASALAISLLDMLQRREVCNHPEAYVRRAVLFAASSVLVSLHPSYIVSTLVEGNLDLSRALEWIRTWALQIADSDIDRDCYTMALSCLQLHAEMALQTSRALESTGGSSSSSSIRPMNISLPSGISKLTSIKLPSSNVHL", "length": 1010 }, "evidence": [ { "id": "E1B7I8", "url": "https://omabrowser.org/oma/group/E1B7I8/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "A0A8V0Z0P5-1", "protein_name": "Telomere length regulation protein TEL2 homolog", "gene_name": "TELO2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAALESALQAAGAGPCPGAEAVGAVRAALAAAGDPAALGERERARLGAFLRNLAAGPEEPAGPWRSLFLESPPDLAFCALTDSLAAPRPGWRLPAVPEVLEQFLRQGRLAALICELCQQHSRPGSVERHDALLGRIVCLPDLVGNGLQGRSPAAFFPQRYFPVLGGAVLQVLHNVSASLRGGLDCSVSFISHILGKVCVHGRQKEILSVLVPHLTDLTKSDCIWQRICWRLVECVPDRWMEAVVLGFVQRAPGADVLSRLLGNLVVKNKKAQFVVTQKMLLLQYGYTTAVLQNLLGYLALDGLRRALLIKVLQELLETWSSSSAVKHSPLEQQQYISKAILICLSHLKEPEIESCRQELLTSMMEGVKCHLDSSLPQIRRLGMIVAESISSKINTDGPVLTFQYEEDDEARELKSLLVQAAPLGVLPGLPDNDRNENADAALPPVLESNRKSTTATTHVMPDEESDAELDSDDDLIPYDMSEDKELKKTKAPVYIRDCIEVLTGSEDLDKWEEAVKALESLVRKNPVAAREVSVELAKILLHLEEKTCLEGFAELRQKAQVAVLTTDPIPVAQYLTSQFYSLNYSLRQRMDILDVLVLAARELSCPKGHGKTKHSGAQNPCIQFLPESGSSKDWRRIVDERIKSKTRRFAKGQSQVEQPSGPNEFNSLAGHFFFPLIQNFDRPLSTFDLLGEDHFVLGRLVHTLAVLMYLAVNTMAVTAMGKALLEFVWALRFHTDSYVRQGLLSCVSSILLSVPAERLLQDVTEELLETRSWLEDVVEKDPDGDCRRLALQNLLLMENLKKKLETAPS", "length": 810 }, "evidence": [ { "id": "E1B7I8", "url": "https://omabrowser.org/oma/group/E1B7I8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7GCU1-1", "protein_name": "Telomere length regulation protein TEL2 homolog", "gene_name": "Telo2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLRSPARRPSADSSRASPLSCKMDPALSAVRLTVQEAIHTLSSSEDVGHILSTLGTLKRYLGGTEDPALPEKEEFTTIHFSAILRCLVSKLSPGWLELSPDGQLEQLWESFFLDGPPDQAFLVLMEAIESTAGPSFRLMKMARLLEIFLSKGRVAALMEEQCRPQTKPSFPLFQETLLSKVVGLPDRLGNSLQQDNLTQFLPQNYFPLLGQEVVEVLKAVVNFLQGGLDCSVSFVSRVLGKVCIQGRKKEILGVLVPQLTVLTQDSCLWQRVCWRLVEQVPDRAVEAVLTGLVEAAPRPEVLSRLLGNLVVKNKKAQFVMTRKLLFLQYQHTTPMLQSLLGYLAVDSQRRPLLIQVLKELLETWGNSSAVRHAPLEQQCYISKAILVCLAHLGEPELQDIQDELLASMMAGVKCRLDSSLPPVRRLGMIVAEVISSRIHPEGPPLKFQYEDDEMSREMLALATPGPAGACSSETGGPSLASVVTETPVETPEKTVDSDVPSVQPQGSDSELDSDDEFIPYDMSGDKELKSSKEPRYIRDCLEALTTSEDMERWEAALNVLEGLVYRSPEATREVSVELAKVLLHLEEKTCMAEFEQLRQRALVAVTVTDPEQVAKYLTTQFYGLNYSLRQRMDILDVLVLAAQALSRPRSLQRLSQHGPPGSGTLCAPALASSQPGNAATPDWQVVVEERIKSKTRRFSKGCPRRELTGGPNEFNSVAGYFFFPLLQHFDRPLVTFDLLGDDQLVLGRLAHTLASLMYLAVNTTVAVPMGKALLEFVWALRFHVDTYVRRGLLSAVSSVLLSVPTERLLGDLPDELLEARSWLADVAEKDVDEDCRELAMRALLLLERLRDKLLSISSP", "length": 859 }, "evidence": [ { "id": "E1B7I8", "url": "https://omabrowser.org/oma/group/E1B7I8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZQ30-1", "protein_name": "Telomere length regulation protein TEL2 homolog", "gene_name": "Telo2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDPALSAVRLTVQEAIHTLSSSEDAGHILSTLGTLKRYLGRTEDPVLPEEKEEFATVHFSAVLRCLVSKLSPGWLELSPDGQLEQLWESFFLDGPPDQAFLVLMEAIESTAGPSFRLMKMARLLDTFLHAGRVAALMEEQCRPQTKPSFPLFQETLLSKVVGLPDLLGNRLQRDNLTQFFPQNYFPLLGLEVMRALKAAVNFLQVLLSVSGGLDCSVSFVSQVLGKVCIQGRKKEILGVLVPQLTVLTQDSCLWQRVCWRLVEQVPDRAVEAVLTGLVEAAPRPEVLSRLLGNLVVKNKKARFVMTRKLLFLQYQHTTPMVQSLLGYLALDSQRRPLLIQVLKELLETWGSSSAVRHAPLEQQCYISKAILVCMAHLGESELQDVRDELLASMMAGVKCRLDSSLPPVRRLGMVVAEVISSRIHPEGPPLKFQYEDDEMSRELLALAAPGPASDCSLEARGPSPAPVATEPPVETPEKTMESDVHPAQPQGSDSELDSDDEFIPYDMSGDKELKSSKEPLYIRDCVEALTTSEDIERWEASLKVLEGLVYRNPQATREVSVELAKVLLHLEEKTCVAEFEQLRQRALVAVTVTDPEQVAKYLTSQFYGLNYSLRQRMDILDVLVLAAQALSRPRSLQRLSQHSSPASGTSRSPALAISQPDWQVVVEERIRSKTRRFSKGCPRREVSGVPNEFNSVAGYFFFPLLQHFDRPLVTFDLLGDDQLVLGRLTHTLASLMYLAVNTTVAVPMGKALLEFVWALRFHVDIYVRRGLLSAVSSVLLSVPTERLLGDLPDELLEARSWLADVAERDVDEDCRELAVRSLLLLERLKDKLLSSCSPQP", "length": 840 }, "evidence": [ { "id": "E1B7I8", "url": "https://omabrowser.org/oma/group/E1B7I8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9DC40-1", "protein_name": "Telomere length regulation protein TEL2 homolog", "gene_name": "Telo2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDPALSAVRLTVQEAIHILSSSEDAGHILSTLGTLKRYLGGTEDPVLPEEKEEFATVHFSAVLRCLVSKLSPGWLELSPGGQLERLWESFFLDGPPDQAFLVLMEAIESTAGPSFRLMKMAQLLDTFLSTGRVAALMEEQCRPQTKPSFPLFQETLLSKVVGLPDLLGNCLQRDNLTQFFPQNYFPLLGQEVVQALKAVVNFLQDGLDCSVSFVSRVLGKVCIQGRKREILSVLVPQLTVLTQDSCLWQRVCWRLVEQVPDRAVEAVLTGLVEAAPRPEVLSRLLGNLVVKNKKARFVVTRKLLLLQYQHTTPMVQSLLGYLALDSQRRPLLIQVLKELLETWGCSSAVRHTPLEQQCYISKAILVCLAHLGEPELQDIRDELLASMMAGVKCRLDSSLPPVRRLGMIVAEVISSRIHPEGPLLKFQYEDDEMSRELLALATPEPAGDCSSVSRGPSPAPVDTESPVEMPEKAVESDVPPTQPQGSDSELDSDDEFIPYDMSGDRELKSSKEPLYIRDCVEALTTSEDMERWEASLKGLEGLVYRSPTATREVSVELAKVLLHLEEKTCVAEFEQLRQSALVAVTVTDPEQVAKYLTSQFYGLNYSLRQRMDILDVLVLAAQALSRPKSLQRRSQHGPPVPGTMCSPALAVSQTGNVAAPDWQVVVEERIRSKTRRFSKGCPQRELSGVPNEFSSVAGYFFFPLLQHFDRPLVTFDLLGDDQLVLGRLTHTLASLMYLAVNTTVAVPMGKALLEFVWALRFHVDIYVRRGLLSAVSSVLLSVPTERLLGDLPDELLEARSWLADVAEKDVDEDCRELAVRALLLLERLKDKLLSSSSPQP", "length": 840 }, "evidence": [ { "id": "E1B7I8", "url": "https://omabrowser.org/oma/group/E1B7I8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y4R8-1", "protein_name": "Telomere length regulation protein TEL2 homolog", "gene_name": "TELO2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPAPSEVRLAVREAIHALSSSEDGGHIFCTLESLKRYLGEMEPPALPREKEEFASAHFSPVLRCLASRLSPAWLELLPHGRLEELWASFFLEGPADQAFLVLMETIEGAAGPSFRLMKMARLLARFLREGRLAVLMEAQCRQQTQPGFILLRETLLGKVVALPDHLGNRLQQENLAEFFPQNYFRLLGEEVVRVLQAVVDSLQGGLDSSVSFVSQVLGKACVHGRQQEILGVLVPRLAALTQGSYLHQRVCWRLVEQVPDRAMEAVLTGLVEAALGPEVLSRLLGNLVVKNKKAQFVMTQKLLFLQSRLTTPMLQSLLGHLAMDSQRRPLLLQVLKELLETWGSSSAIRHTPLPQQRHVSKAVLICLAQLGEPELRDSRDELLASMMAGVKCRLDSSLPPVRRLGMIVAEVVSARIHPEGPPLKFQYEEDELSLELLALASPQPAGDGASEAGTSLVPATAEPPAETPAEIVDGGVPQAQLAGSDSDLDSDDEFVPYDMSGDRELKSSKAPAYVRDCVEALTTSEDIERWEAALRALEGLVYRSPTATREVSVELAKVLLHLEEKTCVVGFAGLRQRALVAVTVTDPAPVADYLTSQFYALNYSLRQRMDILDVLTLAAQELSRPGCLGRTPQPGSPSPNTPCLPEAAVSQPGSAVASDWRVVVEERIRSKTQRLSKGGPRQGPAGSPSRFNSVAGHFFFPLLQRFDRPLVTFDLLGEDQLVLGRLAHTLGALMCLAVNTTVAVAMGKALLEFVWALRFHIDAYVRQGLLSAVSSVLLSLPAARLLEDLMDELLEARSWLADVAEKDPDEDCRTLALRALLLLQRLKNRLLPPASP", "length": 837 }, "evidence": [ { "id": "E1B7I8", "url": "https://omabrowser.org/oma/group/E1B7I8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B7I8", "url": "https://www.uniprot.org/uniprotkb/E1B7I8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B7I8", "url": "https://www.uniprot.org/uniprotkb/E1B7I8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1B7I8", "url": "https://www.uniprot.org/uniprotkb/E1B7I8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B7I8", "url": "https://www.uniprot.org/uniprotkb/E1B7I8" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "E1B7I8", "url": "https://www.uniprot.org/uniprotkb/E1B7I8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "E1B7I8", "url": "https://www.uniprot.org/uniprotkb/E1B7I8" } ], "pmid": "" }, { "name": "'de novo' cotranslational protein folding", "id": "GO:0051083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051083", "evidence": [ { "database": "UniProtKB", "id": "E1B7I8", "url": "https://www.uniprot.org/uniprotkb/E1B7I8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "E1B7I8", "url": "https://www.uniprot.org/uniprotkb/E1B7I8" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "E1B7I8", "url": "https://www.uniprot.org/uniprotkb/E1B7I8" } ], "pmid": "" }, { "name": "telomeric DNA binding", "id": "GO:0042162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042162", "evidence": [ { "database": "UniProtKB", "id": "E1B7I8", "url": "https://www.uniprot.org/uniprotkb/E1B7I8" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "E1B7I8", "url": "https://www.uniprot.org/uniprotkb/E1B7I8" } ], "pmid": "" }, { "name": "Hsp90 protein binding", "id": "GO:0051879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051879", "evidence": [ { "database": "UniProtKB", "id": "E1B7I8", "url": "https://www.uniprot.org/uniprotkb/E1B7I8" } ], "pmid": "" }, { "name": "protein-containing complex stabilizing activity", "id": "GO:0140777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140777", "evidence": [ { "database": "UniProtKB", "id": "E1B7I8", "url": "https://www.uniprot.org/uniprotkb/E1B7I8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 600, "end_pos": 602, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7I8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 826, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7I8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7I8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7I8" }, { "id": "PF25320", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25320" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TELO2 ARM repeat", "eco_id": "ECO_0000259", "start_pos": 324, "end_pos": 422, "start_aa": "Met", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7I8" }, { "id": "PF10193", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10193" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Telomere length regulation protein conserved", "eco_id": "ECO_0000259", "start_pos": 509, "end_pos": 617, "start_aa": "Pro", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 600, "end_pos": 602 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B7X1-1", "uniprot_ac": "E1B7X1", "uniprot_id": "E1B7X1_BOVIN", "mass": { "chemical_mass": 48788.0, "monoisotopic_mass": 48788.0 }, "refseq": { "ac": "NP_776987", "name": "KICSTOR complex protein ITFG2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776987" }, "gene_names": [ { "name": "ITFG2", "type": "recommended", "evidence": [ { "id": "E1B7X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X1" } ] }, { "name": "ADP50", "type": "synonym", "evidence": [ { "id": "NP_776987", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776987" } ] }, { "name": "ITFG2", "type": "synonym", "evidence": [ { "id": "NP_776987", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776987" } ] }, { "name": "MDS028", "type": "synonym", "evidence": [ { "id": "NP_776987", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776987" } ] } ], "protein_names": [ { "name": "Integrin alpha FG-GAP repeat containing 2", "type": "synonym", "evidence": [ { "id": "E1B7X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X1/entry#names_and_taxonomy" } ] }, { "name": "KICSTOR complex protein ITFG2", "type": "synonym", "evidence": [ { "id": "NP_776987", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776987" } ] }, { "name": "adrenal medulla 50 kDa protein", "type": "synonym", "evidence": [ { "id": "NP_776987", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776987" } ] }, { "name": "integrin-alpha FG-GAP repeat-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_776987", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776987" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7X1", "url": "https://www.uniprot.org/uniprotkb/E1B7X1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ITFG2", "url": "https://www.uniprot.org/uniprotkb/E1B7X1", "locus": { "chromosome": "5", "start_pos": 106928854, "end_pos": 106938305, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007609", "url": "https://www.ensembl.org/id/ENSBTAG00000007609" } ] } } ], "crossref": [ { "id": "E1B7X1", "url": "https://alphafold.ebi.ac.uk/entry/E1B7X1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007609", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007609", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "282275", "url": "https://www.ncbi.nlm.nih.gov/gene/282275", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031793", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031793", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282275", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282275", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LNKWECA", "url": "https://omabrowser.org/oma/group/LNKWECA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR16317", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16317", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16317:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16317:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15907", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15907", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_776987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776987", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLF1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLF1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLF1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7X1", "url": "https://www.uniprot.org/uniprotkb/E1B7X1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7X1-1", "url": "https://www.uniprot.org/uniprotkb/E1B7X1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSVSYVQRVALEFSGSLFPHAICLGDVDNDTLNELVVGDTSGKLSVYKNDDSRPWLTCSCQGMLTCVGVGDVCNKGKNLVVAVSAEGWFHLCDLTPAKSLDGSGHHETLGGEEQRPVFKQHIPANTKVMLISDIDGDGRCELVVGYTDRVVRAFRWEDLGEGAEHPMGQLVLLKKWMLEGQVDSLSVTPGPLGVPELMVSQPGCAYAILLCTWNKDPGATPTSEGPMEGTREPLAARDVVLHQTSGRIHNKNVSTHLIGNIKRGHSPDSSASGLFALCTLDGTLKLMEEADRLLWSVQVDHQLFALEKLDVTGNGHEEVVACAWDGQTYIIDHNRTVVRFQVDENIRAFCAGLYACKDSRNSPCLVYVTFNQKIYVYWEVQLERMESTNLLKVLEAQPEFRELLGELGVDPDELPAARALLHQTLYHPNQPPQCSPAGPQDPT", "length": 444, "header": "tr|E1B7X1-1|E1B7X1_BOVIN Isoform 1 of Integrin alpha FG-GAP repeat containing 2 OS=Bos taurus OX=9913 GN=ITFG2 PE=4 SV=2 CANONICAL=E1B7X1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MLF1-1", "url": "https://www.uniprot.org/uniprotkb/E1B7X1/entry#A0A3Q1MLF1-1", "sequence": { "sequence": "MRSVSYVQRVALEFSGSLFPHAICLGDVDNDTLNELVVGDTSGKLSVYKNDDSRPWLTCSCQGMNLVVAVSAEGWFHLCDLTPAKSLDGSGHHETLGGEEQRPVFKQHIPANTKVMLISDIDGDGRCELVVGYTDRVVRAFRWEDLGEGAEHPMGQLVLLKKWMLEGQVDSLSVTPGPLGVPELMVSQPGCAYAILLCTWNKDPGATPTSEGPMEGTREPLAARDVVLHQTSGRIHNKNVSTHLIGNIKRGHSPDSSASGLFALCTLDGTLKLMEEADRLLWSVQVDHQLFALEKLDVTGNGHEEVVACAWDGQTYIIDHNRTVVRFQVDENIRAFCAGLYACKDSRNSPCLVYVTFNQKIYVYWEVQLERMESTNLLKVLEAQPEFRELLGELGVDPDELPAARALLHQTLYHPNQPPQCSPAGPQDPT", "length": 430, "header": "tr|A0A3Q1MLF1-1|E1B7X1_BOVIN Computationally mapped isoform of Integrin alpha FG-GAP repeat containing 2 OS=Bos taurus OX=9913 GN=ITFG2 PE=4 SV=1 CANONICAL=E1B7X1-1" }, "locus": { "chromosome": "5", "start_pos": 106938181, "end_pos": 106929515, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074809.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074809.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071841.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071841.1" } ] } }, { "isoform_ac": "E1B7X1-1", "url": "https://www.uniprot.org/uniprotkb/E1B7X1/entry#E1B7X1-1", "sequence": { "sequence": "MRSVSYVQRVALEFSGSLFPHAICLGDVDNDTLNELVVGDTSGKLSVYKNDDSRPWLTCSCQGMLTCVGVGDVCNKGKNLVVAVSAEGWFHLCDLTPAKSLDGSGHHETLGGEEQRPVFKQHIPANTKVMLISDIDGDGRCELVVGYTDRVVRAFRWEDLGEGAEHPMGQLVLLKKWMLEGQVDSLSVTPGPLGVPELMVSQPGCAYAILLCTWNKDPGATPTSEGPMEGTREPLAARDVVLHQTSGRIHNKNVSTHLIGNIKRGHSPDSSASGLFALCTLDGTLKLMEEADRLLWSVQVDHQLFALEKLDVTGNGHEEVVACAWDGQTYIIDHNRTVVRFQVDENIRAFCAGLYACKDSRNSPCLVYVTFNQKIYVYWEVQLERMESTNLLKVLEAQPEFRELLGELGVDPDELPAARALLHQTLYHPNQPPQCSPAGPQDPT", "length": 444, "header": "tr|E1B7X1-1|E1B7X1_BOVIN Isoform 1 of Integrin alpha FG-GAP repeat containing 2 OS=Bos taurus OX=9913 GN=ITFG2 PE=4 SV=2 CANONICAL=E1B7X1-1" }, "locus": { "chromosome": "5", "start_pos": 106938181, "end_pos": 106929515, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010004.6", "url": "https://www.ensembl.org/id/ENSBTAT00000010004.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010004.5", "url": "https://www.ensembl.org/id/ENSBTAP00000010004.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 189, "start_aa": "Thr", "end_pos": 189, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr189", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 221, "start_aa": "Thr", "end_pos": 221, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr221", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:282275", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282275", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LWZ2-1", "protein_name": "Integrin alpha FG-GAP repeat containing 2", "gene_name": "Itfg2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRSVSYVQRVALDFSGSLFPHAICLGDVDNDALNELVVGDTSGKLYVYKSDDSRPWLTCACQGMLTCVGVGDVCNKGKNLVVAVSAEGWLHLFDLTPTKALDASGHHETLVEEQRPVFKQHIPANTKVMLISDIDGDGCYELVVGYTDRVVRAFRWEELTEGPEHLAGQLVSLKKWMLEGQVDSLSVTPGPLGVPELVVSQPGCAYAVLLCTWNKDTGSPPASEEATGDSRETPAARDVVLHQTSGRIHNKNVSTHLIGNIKQGHYPESGNAGLFALCTLDGTLKLMQEADKLLWSVQVDHQLFALEKLDVTGNGLEEVVACAWDGQTYIIDHNRTVVRFQVDENIRAFCAGQYACKEGRNSPCLVYVTFNQKIYVYWEVQLERMESTNLLKLLEAEPEYHSLLQELGVDRASLAITEMATLTGHRASRLPLPIPVSSPGITSVTMQDHKESYL", "length": 454 }, "evidence": [ { "id": "E1B7X1", "url": "https://omabrowser.org/oma/group/E1B7X1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SK87-1", "protein_name": "Integrin alpha FG-GAP repeat containing 2", "gene_name": "ITFG2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRSVSYVQRVALEFSGSLFPHAICLGDVDNDTLNELVVGDTSGKLLVYKNDDSRPWLTCSCQGMLTCVGVGDVCNKGKNLVVAVSAEGWFHLCDLTPAKALDASGHHETLVGEEQRPVFKQHIPANTKVMLISDIDGDGRCELVLGYTDRVVRAFRWEDLGDGTEHLMGQLVSLKKWMLEGQVDSLSVTPGPLGVPELMVSQPGCAYAILLCTWNKDPGAPPTSEVPSEGTRETPAARDVVLHQTSGRIHNKNVSTHLVGNIKRGHSPESGASGLFALCTLDGTLKLMEQADKLLWSVQVDHQLFALEKLDVTGNGHEEVVACAWDGQTYIIDHNRTVVRFQVDENIRAFCTGLYACKGGHNSPCLVYVTFNQKIYVYWEVQLERMESTNLLKLLEAEPEYRDLLQELGVDPDDLPAARALLHHSLYHPDQAPRCAPTGLQGPT", "length": 444 }, "evidence": [ { "id": "E1B7X1", "url": "https://omabrowser.org/oma/group/E1B7X1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GUI4-1", "protein_name": "KICSTOR complex protein ITFG2 isoform X1", "gene_name": "Itfg2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRSVSYVQRVALDFSGSLFPHAICLGDVDNDALNELVVGDTSGKLSVYKNDDSRPWLTCSCQGMLTCVGVGDVCNKGKNLVVAVSAEGWLHLFDLTSTKALDASGHHETLGEEQRPVFKQHIPANTKVMLISDIDGDGCYELVVGYTDRVVRAFRWEEMAEAPEHLTGQLVSLKKWMLEGQVDSLSVTPGPLGVPELVVSQPGCAYAVLLCTWNKDTGSPPASEEATGDSRETPAARDIVLHQTSGRIHNKNVSTHLIGNIKQGHNPETGNSGLFALCTLDGTLKLMQEADKLLWSVQVDHQLFALEKLDVTGNGLEEVVACAWDGQTYIIDHNRTVVRFQVDENIRAFCAGQYACKEGRNSPCLVYVTFNQKIYVYWDVVLERMASTNLLKLLEAEPEYHSLLQELHVDPEDLPAVRALLHQTLYHPDQTPQCAPSSSQDPT", "length": 443 }, "evidence": [ { "id": "E1B7X1", "url": "https://omabrowser.org/oma/group/E1B7X1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5RHI2-1", "protein_name": "KICSTOR complex protein ITFG2", "gene_name": "itfg2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRSVSYVQRVSLDFTGTLFPHAICLGDADNDSLNELVVGDTSGKLYIYKNDDCKPWITRSCVGMLTCVGVGDVCNKGRNVVVAVGAEGWFHLFDISSAAAKSDSSSQQDGSTGDEQKPSYTQHIPANTKVMLISDIDGDGRCELVVGYTDRVVRAFRWEEPSDASDMSSGQLVLLKKWLLEGQVDSLSVNPSPEGLPELMVSQPGCGYAILMCSWTQEGAAGPGDENTATPSREGSSRDVVLHLTTGRIHNKNVSTHLIGSISRGSKDESSKGGLFALCTLDGTLKLMDSSEKLLWSVQVDHQLFALQKLDVTGDGREEVVACAWDGQTYIIDHTRMVVRFQFDENVNAFCAGQYACKDGRNSPCLVYVSFNHKIYVYWRVELERMEPTNLLSVLEDRPEYPHLLHRLGVDMSDTVAVRKLIGDVLYKNIPKDGAQ", "length": 436 }, "evidence": [ { "id": "E1B7X1", "url": "https://omabrowser.org/oma/group/E1B7X1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q91WI7-1", "protein_name": "KICSTOR complex protein ITFG2", "gene_name": "Itfg2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRSVSYVQRVALDFSGSLFPHAICLGDVDNDALNELVVGDTSGKLSVYKNDDSRPWLTCMCQGMLTCVGVGDVCNKGKNLVVAVSAEGWLHLFDLTPTKALDASGHHETLGEEQRPVFKQHIPANTKVMLISDIDGDGCYELVVGYTDRVVRAFRWEELAEGPEHLAGQLVSLKKWMLEGQVDSLSVTPGPLGVPELVVSQPGCAYAVLLCTWNKDTGSPPASEEATGDSRETPAARDVVLHQTSGRIHNKNVSTHLIGNIRQGHNPEGGNAGLFALCTLDGTLKLMQEADKLLWSVQVDHQLFALEKLDVTGNGLEEVVACAWDGQTYIIDHNRTVVRFQVDENIRAFCAGQYACKEGRNSPCLVYVTFNQKIYVYWEVQLERMESTNLLKLLEAEPEYHRLLQELRVDPEDLPAVCTLLHQTLYHPDQPLQCTPSSFQDPT", "length": 443 }, "evidence": [ { "id": "E1B7X1", "url": "https://omabrowser.org/oma/group/E1B7X1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q969R8-1", "protein_name": "KICSTOR complex protein ITFG2", "gene_name": "ITFG2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRSVSYVQRVALEFSGSLFPHAICLGDVDNDTLNELVVGDTSGKVSVYKNDDSRPWLTCSCQGMLTCVGVGDVCNKGKNLLVAVSAEGWFHLFDLTPAKVLDASGHHETLIGEEQRPVFKQHIPANTKVMLISDIDGDGCRELVVGYTDRVVRAFRWEELGEGPEHLTGQLVSLKKWMLEGQVDSLSVTLGPLGLPELMVSQPGCAYAILLCTWKKDTGSPPASEGPTDGSRETPAARDVVLHQTSGRIHNKNVSTHLIGNIKQGHGTESSGSGLFALCTLDGTLKLMEEMEEADKLLWSVQVDHQLFALEKLDVTGNGHEEVVACAWDGQTYIIDHNRTVVRFQVDENIRAFCAGLYACKEGRNSPCLVYVTFNQKIYVYWEVQLERMESTNLVKLLETKPEYHSLLQELGVDPDDLPVTRALLHQTLYHPDQPPQCAPSSLQDPT", "length": 447 }, "evidence": [ { "id": "E1B7X1", "url": "https://omabrowser.org/oma/group/E1B7X1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "KICSTOR complex", "id": "GO:0140007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140007", "evidence": [ { "database": "UniProtKB", "id": "E1B7X1", "url": "https://www.uniprot.org/uniprotkb/E1B7X1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1B7X1", "url": "https://www.uniprot.org/uniprotkb/E1B7X1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B7X1", "url": "https://www.uniprot.org/uniprotkb/E1B7X1" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "E1B7X1", "url": "https://www.uniprot.org/uniprotkb/E1B7X1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cellular response to glucose starvation", "id": "GO:0042149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042149", "evidence": [ { "database": "UniProtKB", "id": "E1B7X1", "url": "https://www.uniprot.org/uniprotkb/E1B7X1" } ], "pmid": "" }, { "name": "cellular response to amino acid starvation", "id": "GO:0034198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034198", "evidence": [ { "database": "UniProtKB", "id": "E1B7X1", "url": "https://www.uniprot.org/uniprotkb/E1B7X1" } ], "pmid": "" }, { "name": "negative regulation of TORC1 signaling", "id": "GO:1904262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904262", "evidence": [ { "database": "UniProtKB", "id": "E1B7X1", "url": "https://www.uniprot.org/uniprotkb/E1B7X1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 30, "end_pos": 32, "annotation": "n_glycosylation_sequon" }, { "start_pos": 335, "end_pos": 337, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7X1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 444, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7X1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7X1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 189, 221 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 253, "end_pos": 255 }, { "start_pos": 30, "end_pos": 32 }, { "start_pos": 335, "end_pos": 337 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCU5-1", "uniprot_ac": "E1BCU5", "uniprot_id": "E1BCU5_BOVIN", "mass": { "chemical_mass": 62566.0, "monoisotopic_mass": 62566.0 }, "refseq": { "ac": "NP_001193828", "name": "max-binding protein MNT", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193828" }, "gene_names": [ { "name": "MNT", "type": "recommended", "evidence": [ { "id": "E1BCU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU5" } ] }, { "name": "MNT", "type": "synonym", "evidence": [ { "id": "NP_001193828", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193828" } ] } ], "protein_names": [ { "name": "Max-binding protein MNT", "type": "recommended", "evidence": [ { "id": "E1BCU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU5/entry#names_and_taxonomy" } ] }, { "name": "MAX binding protein", "type": "synonym", "evidence": [ { "id": "NP_001193828", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193828" } ] }, { "name": "Myc antagonist MNT", "type": "synonym", "evidence": [ { "id": "E1BCU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU5/entry#names_and_taxonomy" } ] }, { "name": "Protein ROX", "type": "synonym", "evidence": [ { "id": "E1BCU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU5/entry#names_and_taxonomy" } ] }, { "name": "max-binding protein MNT", "type": "synonym", "evidence": [ { "id": "NP_001193828", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193828" } ] } ], "function": [ { "annotation": "Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.", "evidence": [ { "database": "UniProtKB", "id": "E1BCU5", "url": "https://www.uniprot.org/uniprotkb/E1BCU5#function" }, { "database": "UniProtKB", "id": "ARBA00057176", "url": "https://www.uniprot.org/uniprotkb/ARBA00057176#function" }, { "database": "UniProtKB", "id": "A0A3Q1MM43", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM43#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCU5", "url": "https://www.uniprot.org/uniprotkb/E1BCU5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MNT", "url": "https://www.uniprot.org/uniprotkb/E1BCU5", "locus": { "chromosome": "19", "start_pos": 23350861, "end_pos": 23368335, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025129", "url": "https://www.ensembl.org/id/ENSBTAG00000025129" } ] } } ], "crossref": [ { "id": "E1BCU5", "url": "https://alphafold.ebi.ac.uk/entry/E1BCU5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025129", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025129", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11402", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11402", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "618576", "url": "https://www.ncbi.nlm.nih.gov/gene/618576", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618576", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618576", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "THAQVNG", "url": "https://omabrowser.org/oma/group/THAQVNG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MM43", "url": "https://www.orthodb.org/?gene=A0A3Q1MM43", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BCU5", "url": "https://www.orthodb.org/?gene=E1BCU5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11969", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11969", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11969:SF99", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11969:SF99", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193828", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MM43", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MM43-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM43-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLN0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCU5", "url": "https://www.uniprot.org/uniprotkb/E1BCU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCU5-1", "url": "https://www.uniprot.org/uniprotkb/E1BCU5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSIETLLEAARFLEWQAQQQQRAREEQERLRLEREREQEQKKANSLARLAHTMPVEEPRTEAPPLPLSPPAPPPAPPPPLATPTPLTVIPIPVVTNSPQPLPPPPPLPPTAQPLPLAPRQPALVSTPGLSIKEPAPLPTRPQVPTPAPLLPDSKATVPPTGSPKPLQPLPTPILTIAPHPGVQPQLAPPQPPPSTLGTLKLAPAEEVKSSEQKKRPGGIGTREVHNKLEKNRRAHLKECFETLKRNIPNVDDKKTSNLSVLRTALRYIQSLKRKEKEYEHEMERLAREKIATQQRLAELKHELSQWMDVLEIDRVLRQTGQPEDDQASTSTASEGEDNIDEDMEEDQAGLGPHKLSHRPHPELPKPPPSTAPAPLPPHPHPHAQPVALSPAHLPGQQPPPQQKTPLPVPPPPPAAPAQTLVPAPAHLVAAAGGGSTVIAHTATTHASVIQTVNHVLQGPGGKHIAHIAPSAPSPAVQLAPATPPISHITVHPATLNHVAHLGSQLPLYPQPVAVSQPVAVSHIAHTLSHQQVNGTAGLGPPATVMAKPAVGAQVVHHPQLVGQTVLNPVTMVTMPSFPVSTLKLA", "length": 585, "header": "tr|E1BCU5-1|E1BCU5_BOVIN Isoform 1 of Max-binding protein MNT OS=Bos taurus OX=9913 GN=MNT PE=4 SV=2 CANONICAL=E1BCU5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MM43-1", "url": "https://www.uniprot.org/uniprotkb/E1BCU5/entry#A0A3Q1MM43-1", "sequence": { "sequence": "MSIETLLEAARFLEWQAQQQQRAREEQERLRLEREREQEQKKANSLARLAHTMPVEEPRTEAPPLPLSPPAPPPAPPPPLATPTPLTVIPIPVVTNSPQPLPPPPPLPPTAQPLPLAPRQPALVSTPGLSIKEPAPLPTRPQVPTPAPLLPDSKATVPPTGSPKPLQPLPTPILTIAPHPGVQPQLAPPQPPPSTLGTLKLAPAEEVKSSEQKKRPGGRAHLKECFETLKRNIPNVDDKKTSNLSVLRTALRYIQSLKRKEKEYEHEMERLAREKIATQQRLAELKHELSQWMDVLEIDRVLRQTGQPEDDQASTSTASEGEDNIDEDMEEDQAGLGPHKLSHRPHPELPKPPPSTAPAPLPPHPHPHAQPVALSPAHLPGQQPPPQQKTPLPVPPPPPAAPAQTLVPAPAHLVAAAGGGSTVIAHTATTHASVIQTVNHVLQGPGGKHIAHIAPSAPSPAVQLAPATPPISHITVHPATLNHVAHLGSQLPLYPQPVAVSQPVAVSHIAHTLSHQQVNGTAGLGPPATVMAKPAVGAQVVHHPQLVGQTVLNPVTMVTMPSFPVSTLKLA", "length": 571, "header": "tr|A0A3Q1MM43-1|E1BCU5_BOVIN Computationally mapped isoform of Max-binding protein MNT OS=Bos taurus OX=9913 GN=MNT PE=4 SV=2 CANONICAL=E1BCU5-1" }, "locus": { "chromosome": "19", "start_pos": 23366890, "end_pos": 23353697, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075542.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075542.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072825.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072825.2" } ] } }, { "isoform_ac": "A0AAA9TLN0-1", "url": "https://www.uniprot.org/uniprotkb/E1BCU5/entry#A0AAA9TLN0-1", "sequence": { "sequence": "MSIETLLEAARFLEWQAQQQQRARVPEEERERI", "length": 33, "header": "tr|A0AAA9TLN0-1|E1BCU5_BOVIN Computationally mapped isoform of Max-binding protein MNT OS=Bos taurus OX=9913 GN=MNT PE=4 SV=1 CANONICAL=E1BCU5-1" }, "locus": { "chromosome": "19", "start_pos": 23366890, "end_pos": 23354741, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097943.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097943.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098125.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098125.1" } ] } }, { "isoform_ac": "E1BCU5-1", "url": "https://www.uniprot.org/uniprotkb/E1BCU5/entry#E1BCU5-1", "sequence": { "sequence": "MSIETLLEAARFLEWQAQQQQRAREEQERLRLEREREQEQKKANSLARLAHTMPVEEPRTEAPPLPLSPPAPPPAPPPPLATPTPLTVIPIPVVTNSPQPLPPPPPLPPTAQPLPLAPRQPALVSTPGLSIKEPAPLPTRPQVPTPAPLLPDSKATVPPTGSPKPLQPLPTPILTIAPHPGVQPQLAPPQPPPSTLGTLKLAPAEEVKSSEQKKRPGGIGTREVHNKLEKNRRAHLKECFETLKRNIPNVDDKKTSNLSVLRTALRYIQSLKRKEKEYEHEMERLAREKIATQQRLAELKHELSQWMDVLEIDRVLRQTGQPEDDQASTSTASEGEDNIDEDMEEDQAGLGPHKLSHRPHPELPKPPPSTAPAPLPPHPHPHAQPVALSPAHLPGQQPPPQQKTPLPVPPPPPAAPAQTLVPAPAHLVAAAGGGSTVIAHTATTHASVIQTVNHVLQGPGGKHIAHIAPSAPSPAVQLAPATPPISHITVHPATLNHVAHLGSQLPLYPQPVAVSQPVAVSHIAHTLSHQQVNGTAGLGPPATVMAKPAVGAQVVHHPQLVGQTVLNPVTMVTMPSFPVSTLKLA", "length": 585, "header": "tr|E1BCU5-1|E1BCU5_BOVIN Isoform 1 of Max-binding protein MNT OS=Bos taurus OX=9913 GN=MNT PE=4 SV=2 CANONICAL=E1BCU5-1" }, "locus": { "chromosome": "19", "start_pos": 23366890, "end_pos": 23353697, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035154.6", "url": "https://www.ensembl.org/id/ENSBTAT00000035154.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035032.4", "url": "https://www.ensembl.org/id/ENSBTAP00000035032.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 145, "start_aa": "Thr", "end_pos": 145, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr145", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 171, "start_aa": "Thr", "end_pos": 171, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr171", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 82, "start_aa": "Thr", "end_pos": 82, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr82", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:618576", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618576", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0U1RRY7-1", "protein_name": "Max-binding protein MNT", "gene_name": "Mnt", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSIETLLEAARFLEWQAQQQQRAREEQERLRLEREREREQEQKRASNLARLAHALPVEEPRVEAPPLPLSPPAPPPAPPPPLATPAPLTVIPIPVVTNSPQSLPPPPPLPPAAQPLPLAPRQPALVSTPGLSIKEPVPLPTRPQVPTPAPLLPDSKTTVAPTGSPKPLQPLPTPILTIAPHPGVQPQLAPQQPPPPTLGTLKLAPAEEAKSSEQKKRPGGIGTREVHNKLEKNRRAHLKECFETLKRNIPNVDDKKTSNLSVLRTALRYIQSLKRKEKEYEHEMERLAREKIATQQRLAELKHELSQWMDVLEIDRVLRQTGQPEDDQASTSTASEGEDNVDEEMEGDRAGLGPPKLNHRPQPELLKAALPTPSTAPAPLPAHPHPHPHPVALSPAHLPVQQQPPQQKTPLPAPPPPPATPTQTLVPAPAHLVATAGGGSTVIAHTATTHASVIQTVNHVLQGPGGKHIAHIAPSAPSPAVQLAPATPPIGHITVHPATLNHVAHLGSQLPLYPQPVAVSQPVAVSHIAHTLSHQQVNGTAGLGPPATVMAKPAVGAQVVHHPQLVGQTVLNPVTMVTMPSFPVSTLKLA", "length": 590 }, "evidence": [ { "id": "E1BCU5", "url": "https://omabrowser.org/oma/group/E1BCU5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A287AGL3-1", "protein_name": "Max-binding protein MNT", "gene_name": "MNT", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSIETLLEAARFLEWQAQQQQRAREEQERLRLERELEQEQKKASSLARLAHALPVEETRIEAPPLPLSPPAPPPAPPPPLATPTPLTVIPIPVVTNSPQPLPPPPPLPPTAQPLPLAPRQPALVSNPGLSIKESAPLPTRPQVPTPAPLLQDSKTTVPPTGSPKPLQPLPTPILTIAPHPGVQPQLAPQQPPQPTLGTLKLAPAEEVKSSEQKKRPGGIGTREVHNKLEKNRRAHLKECFETLKRNIPNVDDKKTSNLSVLRTALRYIQSLKRKEKEYEHEMERLAREKIAMQQRLAELKHELSQWMDVLEIDRVLRQTGQPEDDQASTSTASEGEDNIDEDMEEDQAGLGPPKLSHRPHPELPKPPPSTAPTPLPSHSHPHSQPVALSPAHLPGQQPPPQQKTPLPAPPPPPAAPAQTLVPAPAHLVAAAGGGSTVIAHTATTHASVIQTVNHVLQGPGGKHIAHIAPSAPSPAVQLAPATPPIGHITVHPATLNHVAHLGSQLPLYPQPVAVSQPVAVSHIAHTLSHQQVNGTAGLGPPATVMAKPAVGAQVVHHPQLVGQTVLNPVTMVTMPSFPVSTLKLA", "length": 585 }, "evidence": [ { "id": "E1BCU5", "url": "https://omabrowser.org/oma/group/E1BCU5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O08789-1", "protein_name": "Max-binding protein MNT", "gene_name": "Mnt", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSIETLLEAARFLEWQAQQQQRAREEQERLRLEREREREQEQKRASNLARLAHALPVEEPRIEAPPLPLSPPAPPPAPPPPLATPAPLTVIPIPVVTNSPQSLPPPPPLPPAAQPLPLAPRQPALVSTPGLSIKEPVTLPTRPQVPTPAPLLPDAKTTVAPTGSPKPLQPLPAPILTIAPHPGVQPQLAPQQPPPPTLGTLKLAPAEEAKSSEQKKRPGGIGTREVHNKLEKNRRAHLKECFETLKRNIPNVDDKKTSNLSVLRTALRYIQSLKRKEKEYEHEMERLAREKIATQQRLAELKHELSQWMDVLEIDRVLRQTGQPEDDQASTSTASEGEDNVDEEMEGDRAGLGPPKLNHRPQPELLKSALPTPSTAPAPLPTHPHPHPHPVALSPAHLPVQQQQPPQQKTPLPAPPPPPATPTQTLVPAPAHLVATAGGGSTVIAHTATTHASVIQTVNHVLQGPGGKHIAHIAPSAPSPAVQLAPATPPIGHITVHPATLNHVAHLGSQLPLYPQPVAVSQPVAVSHIAHTLSHQQVNGTAGLGPPATVMAKPAVGAQVVHHPQLVGQTVLNPVTMVTMPSFPVSTLKLA", "length": 591 }, "evidence": [ { "id": "E1BCU5", "url": "https://omabrowser.org/oma/group/E1BCU5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q99583-1", "protein_name": "Max-binding protein MNT", "gene_name": "MNT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSIETLLEAARFLEWQAQQQQRAREEQERLRLEQEREQEQKKANSLARLAHTLPVEEPRMEAPPLPLSPPAPPPAPPPPLATPAPLTVIPIPVVTNSPQPLPPPPPLPAAAQPLPLAPRQPALVGAPGLSIKEPAPLPSRPQVPTPAPLLPDSKATIPPNGSPKPLQPLPTPVLTIAPHPGVQPQLAPQQPPPPTLGTLKLAPAEEVKSSEQKKRPGGIGTREVHNKLEKNRRAHLKECFETLKRNIPNVDDKKTSNLSVLRTALRYIQSLKRKEKEYEHEMERLAREKIATQQRLAELKHELSQWMDVLEIDRVLRQTGQPEDDQASTSTASEGEDNIDEDMEEDRAGLGPPKLSHRPQPELLKSTLPPPSTTPAPLPPHPHPHPHSVALPPAHLPVQQQQPQQKTPLPAPPPPPAAPAQTLVPAPAHLVATAGGGSTVIAHTATTHASVIQTVNHVLQGPGGKHIAHIAPSAPSPAVQLAPATPPIGHITVHPATLNHVAHLGSQLPLYPQPVAVSHIAHTLSHQQVNGTAGLGPPATVMAKPAVGAQVVHHPQLVGQTVLNPVTMVTMPSFPVSTLKLA", "length": 582 }, "evidence": [ { "id": "E1BCU5", "url": "https://omabrowser.org/oma/group/E1BCU5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BCU5", "url": "https://www.uniprot.org/uniprotkb/E1BCU5" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "E1BCU5", "url": "https://www.uniprot.org/uniprotkb/E1BCU5" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "E1BCU5", "url": "https://www.uniprot.org/uniprotkb/E1BCU5" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "E1BCU5", "url": "https://www.uniprot.org/uniprotkb/E1BCU5" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BCU5", "url": "https://www.uniprot.org/uniprotkb/E1BCU5" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "E1BCU5", "url": "https://www.uniprot.org/uniprotkb/E1BCU5" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BCU5", "url": "https://www.uniprot.org/uniprotkb/E1BCU5" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BCU5", "url": "https://www.uniprot.org/uniprotkb/E1BCU5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BCU5", "url": "https://www.uniprot.org/uniprotkb/E1BCU5" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BCU5", "url": "https://www.uniprot.org/uniprotkb/E1BCU5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BCU5", "url": "https://www.uniprot.org/uniprotkb/E1BCU5" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BCU5", "url": "https://www.uniprot.org/uniprotkb/E1BCU5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 533, "end_pos": 535, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCU5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 585, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCU5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCU5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU5" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 220, "end_pos": 271, "start_aa": "Gly", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 82, 145, 171 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 257, "end_pos": 259 }, { "start_pos": 533, "end_pos": 535 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B6X6-1", "uniprot_ac": "E1B6X6", "uniprot_id": "E1B6X6_BOVIN", "mass": { "chemical_mass": 170576.0, "monoisotopic_mass": 170576.0 }, "refseq": { "ac": "NP_001179112", "name": "tyrosine-protein kinase BAZ1B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179112" }, "gene_names": [ { "name": "BAZ1B", "type": "recommended", "evidence": [ { "id": "E1B6X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ] }, { "name": "BAZ1B", "type": "synonym", "evidence": [ { "id": "NP_001179112", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179112" } ] } ], "protein_names": [ { "name": "Tyrosine-protein kinase BAZ1B", "type": "recommended", "evidence": [ { "id": "E1B6X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X6/entry#names_and_taxonomy" } ] }, { "name": "2.7.10.2", "type": "synonym", "evidence": [ { "id": "E1B6X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X6/entry#names_and_taxonomy" } ] }, { "name": "Bromodomain adjacent to zinc finger domain protein 1B", "type": "synonym", "evidence": [ { "id": "E1B6X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X6/entry#names_and_taxonomy" } ] }, { "name": "tyrosine-protein kinase BAZ1B", "type": "synonym", "evidence": [ { "id": "NP_001179112", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179112" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B6X6", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BAZ1B", "url": "https://www.uniprot.org/uniprotkb/E1B6X6", "locus": { "chromosome": "25", "start_pos": 33729479, "end_pos": 33673326, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005197", "url": "https://www.ensembl.org/id/ENSBTAG00000005197" } ] } } ], "crossref": [ { "id": "ENSBTAG00000005197", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005197", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05505", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05505", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15628", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15628", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508442", "url": "https://www.ncbi.nlm.nih.gov/gene/508442", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001487", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001487", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018359", "database": "InterPro", "categories": [ "Protein 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"InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047174", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047174", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047256", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047256", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508442", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508442", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KVCRRKV", "url": "https://omabrowser.org/oma/group/KVCRRKV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B6X6", "url": "https://www.orthodb.org/?gene=E1B6X6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46802", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46802", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46802:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46802:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00439", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00439", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10537", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10537", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15613", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15613", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5250924", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5250924", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693565", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179112", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10596", "url": "https://www.rhea-db.org/rhea/10596", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MNQ9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MNQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B6X6", "url": "https://www.uniprot.org/uniprotkb/E1B6X6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B6X6-1", "url": "https://www.uniprot.org/uniprotkb/E1B6X6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPLLGRKPFPLVKPLPGEEPLFTIAHTQEAFRTREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFEVGKEKMLKVRIVKIHPLEKVDEEATEKKSDGSCDSPSSDKENSSQIAQDHQKKEAVGKEEEGRRESINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQDEDKIISNVPADSLIRTERPPNKEILRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNPSTKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLNGSPLKVKNSKNSKSPEEHLEEVMKMMSPNKLHANFHIPKKGPPGKKSGKHSDKPLKAKGRGKGILNGQKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKVTRAPRNSGGTPRSSSKPHKHLPPAALHLIAYYKENKDREDKKSALSCVISKTARLLSSEDRARLPEELRSIVQKRFELLEHKKRWASMSEEQRKEYLKKKREELKEKLKEKAKERREKEMLERLEKQKRYEDQELTGKTLPTFKLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSAEKGGFLYLNRVLVILLQTLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRKSDVQEESEGSDADDNKDSASFEDNEVQDEFLEKLETSEFFELTSEEKLQILTALCHRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEARNKENGKEENGLGKADRKKEVVKFEPQVDTEAEDMISAVKSRRLLAIQAKKEREIQEREMKVKLEREAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSIDYRFSHHRKDHADSPDEDYCPRSKKANLGKNVSTNMHHGPAAEIAVETTVPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEKRYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFMAPKQKRRKLQSEDSAKTEEVDEEKKMAEEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDESNEEEEEEEEEEEEDYEVAGLRLRPRKTVRGKQGVIPPTARPGRRPGKKPHPARRARPKAPPADDMEVDELVLQTKRSSRRQSLELQKCEEILHKIVKYRFSWPFREPVTRDEAEDYYDIITHPMDFQTMQSKCSCGGYRSVQEFLADLKQVFTNAELYNCRGSHVLSCMVKTEQCLVALLHKHLPGHPYVRRKRKKFPDRLAEDEGDSEPEPVGQSRGRRQKK", "length": 1482, "header": "tr|E1B6X6-1|E1B6X6_BOVIN Isoform 1 of Tyrosine-protein kinase BAZ1B OS=Bos taurus OX=9913 GN=BAZ1B PE=3 SV=3 CANONICAL=E1B6X6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MNQ9-1", "url": "https://www.uniprot.org/uniprotkb/E1B6X6/entry#A0A3Q1MNQ9-1", "sequence": { "sequence": "MATSTRSERLPHGCCANPEKINMSVVPMVPLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFEVGKEKMLKVRIVKIHPLEKVDEEATEKKSDGSCDSPSSDKENSSQIAQDHQKKEAVGKEEEGRRESINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQDEDKIISNVPADSLIRTERPPNKEILRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNPSTKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLNGSPLKVKNSKNSKSPEEHLEEVMKMMSPNKLHANFHIPKKGPPGKKSGKHSDKPLKAKGRGKGILNGQKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKVTRAPRNSGGTPRSSSKPHKHLPPAALHLIAYYKENKDREDKKSALSCVISKTARLLSSEDRARLPEELRSIVQKRFELLEHKKRWASMSEEQRKEYLKKKREELKEKLKEKAKERREKEMLERLEKQKRYEDQELTGKTLPTFKLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSAEKGGFLYLNRVLVILLQTLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRKSDVQEESEGSDADDNKDSASFEDNEVQDEFLEKLETSEFFELTSEEKLQILTALCHRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEARNKENGKEENGLGKADRKKEVVKFEPQVDTEAEDMISAVKSRRLLAIQAKKEREIQEREMKVKLEREAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSIDYRFSHHRKDHADSPDEDYCPRSKKANLGKNVSTNMHHGPAAEIAVETTVPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEKRYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFMAPKQKRRKLQSEDSAKTEEVDEEKKMAEEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDESNEEEEEEEEEEEEDYEVAGLRLRPRKTVRGKQGVIPPTARPGRRPGKKPHPARRARPKAPPADDMEVDELVLQTKRSSRRQSLELQKCEEILHKIVKYRFSWPFREPVTRDEAEDYYDIITHPMDFQTMQSKCSCGGYRSVQEFLADLKQVFTNAELYNCRGSHVLSCMVKTEQCLVALLHKHLPGHPYVRRKRKKFPDRLAEDEGDSEPEPVGQSRGRRQKK", "length": 1437, "header": "tr|A0A3Q1MNQ9-1|E1B6X6_BOVIN Computationally mapped isoform of Tyrosine-protein kinase BAZ1B OS=Bos taurus OX=9913 GN=BAZ1B PE=3 SV=1 CANONICAL=E1B6X6-1" }, "locus": { "chromosome": "25", "start_pos": 33727702, "end_pos": 33685407, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072070.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072070.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071218.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071218.2" } ] } }, { "isoform_ac": "E1B6X6-1", "url": "https://www.uniprot.org/uniprotkb/E1B6X6/entry#E1B6X6-1", "sequence": { "sequence": "MAPLLGRKPFPLVKPLPGEEPLFTIAHTQEAFRTREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFEVGKEKMLKVRIVKIHPLEKVDEEATEKKSDGSCDSPSSDKENSSQIAQDHQKKEAVGKEEEGRRESINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQDEDKIISNVPADSLIRTERPPNKEILRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNPSTKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLNGSPLKVKNSKNSKSPEEHLEEVMKMMSPNKLHANFHIPKKGPPGKKSGKHSDKPLKAKGRGKGILNGQKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKVTRAPRNSGGTPRSSSKPHKHLPPAALHLIAYYKENKDREDKKSALSCVISKTARLLSSEDRARLPEELRSIVQKRFELLEHKKRWASMSEEQRKEYLKKKREELKEKLKEKAKERREKEMLERLEKQKRYEDQELTGKTLPTFKLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSAEKGGFLYLNRVLVILLQTLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRKSDVQEESEGSDADDNKDSASFEDNEVQDEFLEKLETSEFFELTSEEKLQILTALCHRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEARNKENGKEENGLGKADRKKEVVKFEPQVDTEAEDMISAVKSRRLLAIQAKKEREIQEREMKVKLEREAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSIDYRFSHHRKDHADSPDEDYCPRSKKANLGKNVSTNMHHGPAAEIAVETTVPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEKRYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFMAPKQKRRKLQSEDSAKTEEVDEEKKMAEEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDESNEEEEEEEEEEEEDYEVAGLRLRPRKTVRGKQGVIPPTARPGRRPGKKPHPARRARPKAPPADDMEVDELVLQTKRSSRRQSLELQKCEEILHKIVKYRFSWPFREPVTRDEAEDYYDIITHPMDFQTMQSKCSCGGYRSVQEFLADLKQVFTNAELYNCRGSHVLSCMVKTEQCLVALLHKHLPGHPYVRRKRKKFPDRLAEDEGDSEPEPVGQSRGRRQKK", "length": 1482, "header": "tr|E1B6X6-1|E1B6X6_BOVIN Isoform 1 of Tyrosine-protein kinase BAZ1B OS=Bos taurus OX=9913 GN=BAZ1B PE=3 SV=3 CANONICAL=E1B6X6-1" }, "locus": { "chromosome": "25", "start_pos": 33727702, "end_pos": 33673612, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006848.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006848.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006848.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006848.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:508442", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508442", "resource": "KEGG Pathway" }, { "id": "R-BTA-5250924", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5250924", "resource": "Reactome", "description": "B-WICH complex positively regulates rRNA expression" }, { "id": "R-BTA-5693565", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693565", "resource": "Reactome", "description": "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6ALC2-1", "protein_name": "Tyrosine-protein kinase BAZ1B", "gene_name": "Baz1b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFRTREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPNWYEKLVLEMVHHNTASLEKLVDSAWLEIMTKYAVGEECDFEVGKEKMLKVKIVKIHPLEKVDEEAAEKKSDGTCDSPSSDKENSSQMAQDHQKETVVKEDGGRRESINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQSEDKIISNVPADSLIRTERPPNKEILRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNPSTKRKNTGSPDRKPSKKPKRDNSSLSSPLNPKLWCHVHLEKSLNGPPLKVKNSKNSKSPEEHLEEVMKIMSPNKLHSFHIPKKGPSTKKPGKHSDKPLKAKGRGKGILNGQKSTGNSKSPSKCVKTPKTKMKQMTLLDMAKGTQKMTRTPRSSGGVPRSSGKPHKHLPPAALHLIAYYKENKDKEDKKSALSCVISKTARLLSSEDRARLPEELRALVQKRYELLEHKKRWASMSEEQRKEYLKKKRQELKERLREKAKERREKEMLERLEKQKRYEDQELGGRNLPTFRLVDTPEGLPNTLFGDVALVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQTLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRCDVQEDSEGSDTDDNKDSTPFEDNEVQDEFLEKLETSEFFELTSEEKLRILTALCHRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEARNKENGKEENVLGKVDRKKEIVKIENQVEVEADDMISAVKSRRLLSMQAKRKREIQERETKVRLEREAEEERVRKHKAAAEKAFQEGIAKAKLVLRRTPIGTDRNHNRYWLFSNEVPGLFIEKGWVHNSIDYRFKHHRKDHNNLPDDDYCPRSKKANLGKNASVNAHLGSALEAVETTVPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEKRYQEITHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYMEGTSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFMAPKQKKRKLQSEDSTKSEEVDEEKKMVEEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPPTARRNSRGRNYTEESTSEDSEGDESGDEEEEEEEEEEEEEDYEVAGLRLRPRKTIRGKQSVIPAARPGRPPGKKSHAARRSRPKDDTEVDELVLQTKRSSRRQSLELQKCEEILHKLVKYRFSWPFREPVTRDEAEDYYDVIDHPMDFQTMQNKCSCGNYRSVQEFLTDVKQVFANAELYNCRGSHVLSCMEKTEQCLLALLQKHLPGHPYVRRKRRKFPDRLADDEGDSDSESVGQSRGRRQKK", "length": 1476 }, "evidence": [ { "id": "E1B6X6", "url": "https://omabrowser.org/oma/group/E1B6X6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V1AMK9-1", "protein_name": "Tyrosine-protein kinase BAZ1B", "gene_name": "BAZ1B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAPLLGRKPFPLAKPLPPGEPGERFIIPHTQEAFRTREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPIWYEKPVLEIVHHNTVSLEKLVDAAWVEIMTKFAVGEECDFEVGKEKMLPVKVVKIHPLEKVDEEASEKKSEGACDSPSSDKENSSQAAQDNQKESVLKEEDSRRESMNDRARRSPRKLPTSLKKEERKWVPPKFLPHKYDVKLKNEDKIISNVPADSLVRTERPPNKEILRYFIRHNALRAGIGENAPWVVEDELVKKYSLPSKFSDFLLDPHKYMTLNPSTKRKSSGSPDRKPSKKSKTDGSSLSQPLSPTLWCHVHLEKSIIGSPLKMKNSKISKCPKEELEEMMKIMSPGKLDSNFHIPKRSRLGKGSNKSLDKKQRGKRVLNGQKTSGKSKSPGKGLKTPKMKMKQMTLLDMAKGTTKVSRTPRNSGGTPRSSSKPQKLPPAALHLIAYYKENKDREDKKSALSCIISKTARLLSNEDRARLPEDLRGLVQKRYELLEHRKKLATMTEEQRKEYLKKKREKLKEKLKERAKERKEKEMKEKLEKNKRFEDQDLKGKNLPTFKLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLMPDAQYPITAVSLMEALCAEKGGFLYLNRVLVILLQTLLQDEIAEDYAELGMKLSEIPLTLHSASELVRLCLRKSDVQEESEVSDNVDESKDSATFEDNEVQDEFLEKLETSEFFELTPEEKLQILGALCHRILMTYSVQDHVEAKQQASAELWKERLAILKEENDKKRAEKQKRKEMVAKNKENGKDENTTGRNEKKKNEIVKIEHRVEIEADDMISAVKSRRLLAIQAKKEREQQERQMRVRMEKEAEEERIRKHKAAAEKTFQDGIAKAKLVMRRTPVGTDRNHNRYWLFSDEVPGLFIEKGWVHDSIDYRFILPHQKKEEAKKDYSSGDKRRSTAADGRTSALHRSAYAADLPAETTAPKQGQNLWFLCDSQKDLDELIDCLHPQGVRESQLKERLEKKYQDITHSMHLARKQNLGLKSCDGNQELLNYLRSDLIEVATRLQKGGLGYVDVTPEFEARVYSLESLKDFGECVIALQAGVIKKFLQGFMAPKQKRRKHQGEDYITKAEEVDEEKKMAEEAKVASAMEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEIPDGEWQCPACQPSTARRSSRGRNYTEDSAEDEGEEGEEASDEQDAEEEEEEEEDYEVAGLKLRPRKAARGKQSTAMYSSRQGRHQRKKQSLHPARGPRQRAAPVNSADIDELVLQTRKTARRQSLELQKCEEILSKLIKYRFSWPFREPVTTEEAEDYCEVISNPMDFQTMQSKCSCGNYRSVQEFLSDMKQVFSNAERYNQNGSHVLSCLEKTEQCLIDMVHKHLPGHTYARRKRKKFSAGCQGLEEQEGDSESEPLEHSRGRRRKK", "length": 1489 }, "evidence": [ { "id": "E1B6X6", "url": "https://omabrowser.org/oma/group/E1B6X6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3LCE6-1", "protein_name": "Tyrosine-protein kinase BAZ1B", "gene_name": "BAZ1B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAPLLGRKPFPLVKPLPGEEPLFTIAHTQEAFRTREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFEVGKEKMLKVRIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHPKKEAIVKENEGRRESINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNKEILRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNPSTKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLNGSPLKVKNSKNSKSPEEHLEEVMKVMSPNKLHGNFHIPKKGPPGKKSGKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRSSSKPHKHLPPAALHLIAYYKENKDREDKKSALSCVISKTARLLSSEDRARLPEELRGIVQKRFELLEHKKRWASMSEEQRKEYLKKKREELKEKLKEKAKERREKEMLERLEKQKRYEDQELTGKNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSAEKGGFLYLNRVLVILLQTLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRKSDVQEESEGSDTDDNKDSAPFDDNEVQDEFLEKLETSEFFELTSEEKLQILTALCHRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEARNKENGKEENGLGKADRKKEVVKFETQVDIEADDMISAVKSRRLLAIQAKKEREIQEREMKVKLEREAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSIDYRFSNHRKDRAASPDEDYCPRTKKANLGKNVNMNTQHGPATEIAVETTVPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEKRYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFMAPKQKRRKLQSEDSAKTEEVDEEKKMAEEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYAVPDGEWQCPACQPATARRNSRGRNYTEESSSEDSEDDESEEEEEEGEEEEEEEDYEVAGLRLRPRKTVRGRQGVVPPAARPGRRPGKKPLPTRRSRPKPPPVDDAEVDELVLQTKRSSRRQSLELQKCEEILHKLVKYRFSWPFREPVTRDEAEDYYDVIAHPMDFQTMQNKCSCGSYRSVQEFLADMKQVFTNAELYNCRGSHVLNCTVKTEQCLVALLHKHLPGHPYVRRKRKKFPDRLAEDEGDSEPEPVGQSRGRRQKK", "length": 1483 }, "evidence": [ { "id": "E1B6X6", "url": "https://omabrowser.org/oma/group/E1B6X6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9UIG0-1", "protein_name": "Tyrosine-protein kinase BAZ1B", "gene_name": "BAZ1B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFRTREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFEVGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVVKEDEGRRESINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNPSTKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSKSPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKKPGKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIAYYKENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKKREELKKKLKEKAKERREKEMLERLEKQKRYEDQELTGKNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQTLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFEDNEVQDEFLEKLETSEFFELTSEEKLQILTALCHRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMISAVKSRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSIDYRFNHHCKDHTVSGDEDYCPRSKKANLGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEKRYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFMAPKQKRRKLQSEDSAKTEEVDEEKKMVEEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDESDEEEEEEEEEEEEEDYEVAGLRLRPRKTIRGKHSVIPPAARSGRRPGKKPHSTRRSQPKAPPVDDAEVDELVLQTKRSSRRQSLELQKCEEILHKIVKYRFSWPFREPVTRDEAEDYYDVITHPMDFQTVQNKCSCGSYRSVQEFLTDMKQVFTNAEVYNCRGSHVLSCMVKTEQCLVALLHKHLPGHPYVRRKRKKFPDRLAEDEGDSEPEAVGQSRGRRQKK", "length": 1483 }, "evidence": [ { "id": "E1B6X6", "url": "https://omabrowser.org/oma/group/E1B6X6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z277-1", "protein_name": "Tyrosine-protein kinase BAZ1B", "gene_name": "Baz1b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFRTREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPNWYEKLVLEMVHHNTASLEKLVDSAWLEIMTKYAVGEECDFEVGKEKMLKVKIVKIHPLEKVDEEAVEKKSDGACDSPSSDKENSSQMAQDLQKKETVVKEDEGRRESINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNKEILRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNPSTKRRNTGSPDRKPSKKPKRDSSSLSSPLNPKLWCHVHLEKSLNGPPLKVKNSKNSKSPEEHLEGVMKIMSPNNNKLHSFHIPKKGPAAKKPGKHSDKPLKAKGRGKGILNGQKSTGNSKSPSKCVKTPKTKMKQMTLLDMAKGTQKMTRTPRSSGGVPRSSGKPHKHLPPAALHLIAYYKENKDKEDKKSALSCVISKTARLLSNEDRARLPEELRALVQKRYELLEHKKRWASMSEEQRKEYLKKKRQELKERLREKAKERREREMLERLEKQKRFEDQELGGRNLPAFRLVDTPEGLPNTLFGDVALVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQTLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRCDVQEDSEGSETDDNKDSTPFEDNEVQDEFLEKLETSEFFELTSEEKLRILTALCHRILMTYSVQDHMETRQQVSAELWKERLAVLKEENDKKRAEKQKRKEMEARNKENGKEENVLGKVDRKKEIVKIEQQVEVEADDMISAVKSRRLLSMQAKRKREIQERETKVRLEREAEEERMRKHKAAAEKAFQEGIAKAKLVLRRTPIGTDRNHNRYWLFSNEVPGLFIEKGWVHNSIDYRFKHHRKDHSNLPDDDYCPRSKKANLGKNASVNAHHGPALEAVETTVPKQGQNLWFLCDSQKELDELLSCLHPQGIRESQLKERLEKRYQEITHSIYLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYMEGTSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFMAPKQKKRKLQSEDSTKSEEVDEEKKMVEEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPPTARRNSRGRNYTEESTSEGSEGDESGEEEEEEEEEEEEEEDYEVAGLRLRPRKTIRGKQSVIPAARPGRPPGKKSHPARRSRPKDDPEVDDLVLQTKRISRRQSLELQKCEDILHKLVKYRFSWPFREPVTRDEAEDYYDVIEHPMDFQTIQNKCSCGNYRSVQEFLTDMKQVFANAELYNCRGSHVLSCMEKTEQCLLALLQKHLPGHPYVRRKRRKFPDRLADDEGDSDSESVGQSRGRRQKK", "length": 1479 }, "evidence": [ { "id": "E1B6X6", "url": "https://omabrowser.org/oma/group/E1B6X6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "non-membrane spanning protein tyrosine kinase activity", "id": "GO:0004715", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004715", "evidence": [ { "database": "UniProtKB", "id": "E1B6X6", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1B6X6", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B6X6", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ], "pmid": "" }, { "name": "histone H2AXY142 kinase activity", "id": "GO:0140801", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140801", "evidence": [ { "database": "UniProtKB", "id": "E1B6X6", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "E1B6X6", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ], "pmid": "" }, { "name": "histone kinase activity", "id": "GO:0035173", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035173", "evidence": [ { "database": "UniProtKB", "id": "E1B6X6", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1B6X6", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "E1B6X6", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "E1B6X6", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ], "pmid": "" }, { "name": "post-translational protein modification", "id": "GO:0043687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043687", "evidence": [ { "database": "UniProtKB", "id": "E1B6X6", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase III", "id": "GO:0045945", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045945", "evidence": [ { "database": "UniProtKB", "id": "E1B6X6", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ], "pmid": "" }, { "name": "negative regulation of mitotic chromosome condensation", "id": "GO:1905213", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905213", "evidence": [ { "database": "UniProtKB", "id": "E1B6X6", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "WICH complex", "id": "GO:0090535", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090535", "evidence": [ { "database": "UniProtKB", "id": "E1B6X6", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ], "pmid": "" }, { "name": "nuclear replication fork", "id": "GO:0043596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043596", "evidence": [ { "database": "UniProtKB", "id": "E1B6X6", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1B6X6", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ], "pmid": "" }, { "name": "condensed chromosome", "id": "GO:0000793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000793", "evidence": [ { "database": "UniProtKB", "id": "E1B6X6", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ], "pmid": "" }, { "name": "pericentric heterochromatin", "id": "GO:0005721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005721", "evidence": [ { "database": "UniProtKB", "id": "E1B6X6", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1244, "end_pos": 1246, "annotation": "n_glycosylation_sequon" }, { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 325, "end_pos": 327, "annotation": "n_glycosylation_sequon" }, { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 964, "end_pos": 966, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10596", "name": "", "equation": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MWN2-1", "A0AAF6DMB3-1", "E1BI01-1", "A0AAA9TQL1-1", "F1MQH2-1", "F1N781-1", "F6QXU6-1", "A0A3Q1MKW9-1", "A0A3Q1M0U5-1", "F6S1J8-1", "A5D791-1", "F1N664-1", "E1BMP9-1", "F1MS00-1", "P43481-1", "A0A3Q1LR28-1", "A0A3Q1LVP1-1", "Q06807-1", "A0AAA9TD48-1", "Q5E9X2-1", "Q05688-1", "Q17R13-1", "E1BG90-1", "Q0VBZ0-1", "F1N758-1", "A0A3Q1LTC6-1", "A0A3Q1LNU2-1", "F1N1Q0-1", "A0A3Q1MHB0-1", "A0AAA9SN20-1", "A0AAA9TMY2-1", "A0A3Q1LI98-1", "E1BJ31-1", "A0A3Q1LRR9-1", "F1MX49-1", "A0A3Q1MHG9-1", "A0JNB0-1", "E1BER5-1", "E1BIM8-1", "E1BNE0-1", "A0A3Q1LT44-1", "A0A3Q1MJG0-1", "F1MII5-1", "F1N0D3-1", "F1N261-1", "F1N759-1", "F1N780-1", "F1MC14-1", "F1N3R6-1", "A0ABI0P1V8-1", "A0A3Q1LUE0-1", "F1MFH7-1", "F1MNW2-1", "A0AAA9SPC9-1", "F1N381-1", "F1MS29-1", "G1K218-1", "Q4TVR5-1", "A0AAA9SXH6-1", "E1BJS9-1", "A0AAA9SBR4-1", "F1MKR1-1", "F1MN51-1", "E1BCZ6-1", "E1BEL4-1", "F1MCX4-1", "F1N6J0-1", "Q3SZJ2-1", "Q769I5-1", "Z4YHD9-1", "Q06805-1", "Q3SX21-1", "A0A3Q1MAM7-1", "E1BPB5-1", "A0A3Q1MF99-1", "A0AAA9SA57-1", "A0AAA9TAT1-1", "A0AAA9THG2-1", "F1MC23-1", "A0AAA9SVL9-1", "F1MRU0-1", "A0AAA9T042-1", "E1BKP7-1", "E1BNA8-1", "F1ML02-1", "E1BPI3-1", "A0AAA9SW95-1", "G3X680-1", "A0AAA9TRY4-1", "A0A3Q1MEZ6-1", "E1B9H4-1", "E1B6X6-1", "E1B9Q2-1", "E1BPP1-1", "F1N6H6-1", "A0ABI0NRQ5-1" ], "evidence": [ { "id": "10596", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10596" } ] }, { "id": "R-BTA-5250930", "name": "B-WICH recruits histone acetyltransferases", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F6QHI8-1", "E1BIX2-1", "A0A3Q1MLT2-1", "E1B8D6-1", "E1BP59-1", "E1B6X6-1" ], "evidence": [ { "id": "R-BTA-5250930", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5250930" } ] }, { "id": "R-BTA-5250938", "name": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F6QHI8-1", "E1BIX2-1", "A0A3Q1MLT2-1", "E1B8D6-1", "E1BP59-1", "E1B6X6-1" ], "evidence": [ { "id": "R-BTA-5250938", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5250938" } ] }, { "id": "R-BTA-5250947", "name": "B-WICH complex binds rDNA promoter", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-ALL-73682", "R-BTA-417140", "R-BTA-417153", "R-BTA-5250643", "R-BTA-5250650", "R-BTA-5250652", "R-BTA-71968" ], "output_participant_list": [ "R-BTA-3321990" ], "enzyme_list": [ "P63258-1", "A0A3Q1NDU7-1", "F6QHI8-1", "E1BIX2-1", "E1B6X6-1" ], "evidence": [ { "id": "R-BTA-5250947", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5250947" } ] }, { "id": "R-BTA-5683930", "name": "WICH phosphorylates H2AFX on Y142", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1B6X6-1" ], "evidence": [ { "id": "R-BTA-5683930", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5683930" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-73682", "participant_name": "rDNA Promoter [nucleoplasm]", "crossref": [ { "id": "61120", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-BTA-3321990", "participant_name": "ACTG1 [nucleoplasm]", "crossref": [ { "id": "107265", "database": "VGNC", "url": "" }, { "id": "P63258", "database": "UniProt", "url": "" } ] }, { "participant_id": "R-BTA-417140", "participant_name": "SMARCA5 [nucleoplasm]", "crossref": [ { "id": "F1N052", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000003399", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000004408", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000004408", "database": "ENSEMBL", "url": "" }, { "id": "34988", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-417153", "participant_name": "BAZ1B [nucleoplasm]", "crossref": [ { "id": "E1B6X6", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000005197", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000006848", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000006848", "database": "ENSEMBL", "url": "" }, { "id": "NP_001179112.3", "database": "RefSeq", "url": "" }, { "id": "26429", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-5250643", "participant_name": "DEK [nucleoplasm]", "crossref": [ { "id": "A5PJQ1", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000012865", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000017097", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000017097", "database": "ENSEMBL", "url": "" }, { "id": "XP_010816794.1", "database": "RefSeq", "url": "" }, { "id": "NP_001093187.1", "database": "RefSeq", "url": "" }, { "id": "XP_024839465.1", "database": "RefSeq", "url": "" }, { "id": "27992", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-5250650", "participant_name": "MYBBP1A [nucleoplasm]", "crossref": [ { "id": "E1BKX3", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000007430", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000009771", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000101080", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000123527", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000009771", "database": "ENSEMBL", "url": "" }, { "id": "XP_010814254.1", "database": "RefSeq", "url": "" }, { "id": "31777", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-5250652", "participant_name": "DDX21 [nucleoplasm]", "crossref": [ { "id": "F6QHI8", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000014558", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000019351", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000019351", "database": "ENSEMBL", "url": "" }, { "id": "97259", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-71968", "participant_name": "SF3B1 [nucleoplasm]", "crossref": [ { "id": "F1MX61", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000008915", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000011734", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000011734", "database": "ENSEMBL", "url": "" }, { "id": "NP_001179923.1", "database": "RefSeq", "url": "" }, { "id": "34509", "database": "VGNC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LI98", "gene_name": "ABL1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LI98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI98" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3Q1LI98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI98" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRR9", "gene_name": "TYRO3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRR9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1LRR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRR9" } ] } ] }, { "uniprot_ac": "A0A3Q1LT44", "gene_name": "NTRK2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LT44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT44" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1LT44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT44" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LUE0", "gene_name": "FGFR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LUE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUE0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1LUE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUE0" } ] } ] }, { "uniprot_ac": "A0A3Q1LVP1", "gene_name": "PTK2B", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LVP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3Q1LVP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP1" } ] } ] }, { "uniprot_ac": "A0A3Q1M0U5", "gene_name": "TIE1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U5" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1M0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U5" } ] } ] }, { "uniprot_ac": "A0A3Q1MAM7", "gene_name": "ROS1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MAM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAM7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1MAM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAM7" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MF99", "gene_name": "TXK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MF99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF99" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3Q1MF99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF99" } ] } ] }, { "uniprot_ac": "A0A3Q1MHB0", "gene_name": "EGFR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHB0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHB0" } ] } ] }, { "uniprot_ac": "A0A3Q1MHG9", "gene_name": "SYK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHG9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3Q1MHG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHG9" } ] } ] }, { "uniprot_ac": "A0A3Q1MJG0", "gene_name": "INSR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MJG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJG0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1MJG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJG0" } ] } ] }, { "uniprot_ac": "A0A3Q1MKW9", "gene_name": "ALK", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKW9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1MKW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKW9" } ] } ] }, { "uniprot_ac": "A0A3Q1MLT2", "gene_name": "KAT2B", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "A0A3Q1MLT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLT2" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A3Q1MLT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLT2" } ] } ] }, { "uniprot_ac": "A0A3Q1NDU7", "gene_name": "GSK3B", "activity": [ { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NDU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDU7" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0A3Q1NDU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDU7" } ] } ] }, { "uniprot_ac": "A0AAA9SA57", "gene_name": "ABL2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SA57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA57" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9SA57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA57" } ] } ] }, { "uniprot_ac": "A0AAA9SBR4", "gene_name": "ERBB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SBR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBR4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9SBR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBR4" } ] } ] }, { "uniprot_ac": "A0AAA9SN20", "gene_name": "FLT1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SN20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN20" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9SN20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN20" } ] } ] }, { "uniprot_ac": "A0AAA9SPC9", "gene_name": "KDR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SPC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPC9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9SPC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPC9" } ] } ] }, { "uniprot_ac": "A0AAA9SVL9", "gene_name": "FLT4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9SVL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL9" } ] } ] }, { "uniprot_ac": "A0AAA9SW95", "gene_name": "TEC", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SW95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW95" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9SW95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW95" } ] } ] }, { "uniprot_ac": "A0AAA9SXH6", "gene_name": "JAK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9SXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH6" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9TAT1", "gene_name": "FGFR3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TAT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9TAT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT1" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9THG2", "gene_name": "EPHB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9THG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG2" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9THG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG2" } ] } ] }, { "uniprot_ac": "A0AAA9TMY2", "gene_name": "WEE2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMY2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9TMY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMY2" } ] } ] }, { "uniprot_ac": "A0AAA9TQL1", "gene_name": "DDR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TQL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQL1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9TQL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQL1" } ] } ] }, { "uniprot_ac": "A0AAA9TRY4", "gene_name": "CSF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TRY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRY4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9TRY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRY4" } ] } ] }, { "uniprot_ac": "A0AAF6DMB3", "gene_name": "DDR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAF6DMB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB3" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0P1V8", "gene_name": "JAK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P1V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1V8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0ABI0P1V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1V8" } ] } ] }, { "uniprot_ac": "A0JNB0", "gene_name": "FYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0JNB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNB0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0JNB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNB0" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "E1B6X6", "gene_name": "BAZ1B", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B6X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1B6X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ] } ] }, { "uniprot_ac": "E1B8D6", "gene_name": "EP300", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "E1B8D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8D6" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "E1B8D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8D6" } ] } ] }, { "uniprot_ac": "E1B9H4", "gene_name": "PKDCC", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9H4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1B9H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9H4" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BCZ6", "gene_name": "MST1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCZ6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BCZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCZ6" } ] } ] }, { "uniprot_ac": "E1BEL4", "gene_name": "JAK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEL4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BEL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEL4" } ] } ] }, { "uniprot_ac": "E1BER5", "gene_name": "EPHA4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BER5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BER5" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BER5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BER5" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BIM8", "gene_name": "SRC", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BIM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIM8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BIM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIM8" } ] } ] }, { "uniprot_ac": "E1BIX2", "gene_name": "POLR1A", "activity": [ { "ec_number": "2.7.7.6", "activity": "RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate.", "evidence": [ { "id": "E1BIX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIX2" } ] }, { "ec_number": "2.7.7.6", "activity": "", "evidence": [ { "id": "E1BIX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIX2" } ] } ] }, { "uniprot_ac": "E1BJ31", "gene_name": "EPHA2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ31" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BJ31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ31" } ] } ] }, { "uniprot_ac": "E1BJS9", "gene_name": "EPHA3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BJS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS9" } ] } ] }, { "uniprot_ac": "E1BKP7", "gene_name": "MUSK", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKP7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BKP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKP7" } ] } ] }, { "uniprot_ac": "E1BMP9", "gene_name": "ZAP70", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BMP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP9" } ] } ] }, { "uniprot_ac": "E1BNA8", "gene_name": "PTK6", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNA8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BNA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNA8" } ] } ] }, { "uniprot_ac": "E1BNE0", "gene_name": "FER", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNE0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BNE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNE0" } ] } ] }, { "uniprot_ac": "E1BP59", "gene_name": "KAT2A", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "E1BP59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP59" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "E1BP59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP59" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPI3", "gene_name": "FRK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "F1MC14", "gene_name": "NTRK1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC14" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MC14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC14" } ] } ] }, { "uniprot_ac": "F1MC23", "gene_name": "INSRR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC23" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MC23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC23" } ] } ] }, { "uniprot_ac": "F1MCX4", "gene_name": "TYK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MCX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCX4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1MCX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCX4" } ] } ] }, { "uniprot_ac": "F1MFH7", "gene_name": "EPHA1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFH7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MFH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFH7" } ] } ] }, { "uniprot_ac": "F1MII5", "gene_name": "EPHB1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MII5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MII5" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MII5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MII5" } ] } ] }, { "uniprot_ac": "F1MKR1", "gene_name": "EPHA8", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKR1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MKR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKR1" } ] } ] }, { "uniprot_ac": "F1ML02", "gene_name": "EPHB3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1ML02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML02" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1ML02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML02" } ] } ] }, { "uniprot_ac": "F1MN51", "gene_name": "FGFR4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN51" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MN51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN51" } ] } ] }, { "uniprot_ac": "F1MNW2", "gene_name": "FGFR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNW2" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MNW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNW2" } ] } ] }, { "uniprot_ac": "F1MQH2", "gene_name": "EPHA6", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQH2" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MQH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQH2" } ] } ] }, { "uniprot_ac": "F1MRU0", "gene_name": "FLT3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MRU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRU0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MRU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRU0" } ] } ] }, { "uniprot_ac": "F1MS00", "gene_name": "RET", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MS00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS00" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MS00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS00" } ] } ] }, { "uniprot_ac": "F1MS29", "gene_name": "PTK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MS29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS29" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1MS29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS29" } ] } ] }, { "uniprot_ac": "F1MWN2", "gene_name": "HCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1MWN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN2" } ] } ] }, { "uniprot_ac": "F1MX49", "gene_name": "PDGFRA", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MX49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX49" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MX49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX49" } ] } ] }, { "uniprot_ac": "F1N0D3", "gene_name": "AXL", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N0D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0D3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N0D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0D3" } ] } ] }, { "uniprot_ac": "F1N1Q0", "gene_name": "SRMS", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N1Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Q0" } ] }, { "ec_number": "2.7.10.2", 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"start_pos": 165, "end_pos": 167 }, { "start_pos": 325, "end_pos": 327 }, { "start_pos": 347, "end_pos": 349 }, { "start_pos": 964, "end_pos": 966 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BB46-1", "uniprot_ac": "E1BB46", "uniprot_id": "E1BB46_BOVIN", "mass": { "chemical_mass": 107096.0, "monoisotopic_mass": 107096.0 }, "refseq": { "ac": "NP_001137560", "name": "SH3 domain-binding protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137560" }, "gene_names": [ { "name": "SH3BP4", "type": "recommended", "evidence": [ { "id": "E1BB46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB46" } ] }, { "name": "SH3BP4", "type": "synonym", "evidence": [ { "id": "NP_001137560", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137560" } ] } ], "protein_names": [ { "name": "SH3 domain-binding protein 4", "type": "recommended", "evidence": [ { "id": "E1BB46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB46/entry#names_and_taxonomy" } ] }, { "name": "SH3 domain-binding protein 4", "type": "synonym", "evidence": [ { "id": "NP_001137560", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137560" } ] } ], "function": [ { "annotation": "May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.", "evidence": [ { "database": "UniProtKB", "id": "E1BB46", "url": "https://www.uniprot.org/uniprotkb/E1BB46#function" }, { "database": "UniProtKB", "id": "ARBA00056144", "url": "https://www.uniprot.org/uniprotkb/ARBA00056144#function" }, { "database": "UniProtKB", "id": "A0A3Q1MPS2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPS2#function" } ] }, { "annotation": "SESN2 negatively regulates the mTORC1 pathway and subsequent CSN2 synthesis through the SH3BP4 in response to amino acids depletion.", "evidence": [ { "database": "RefSeq", "id": "NP_001137560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137560" }, { "database": "PubMed", "id": "30969118", "url": "https://glygen.org/publication/PubMed/30969118" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BB46", "url": "https://www.uniprot.org/uniprotkb/E1BB46" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SH3BP4", "url": "https://www.uniprot.org/uniprotkb/E1BB46", "locus": { "chromosome": "3", "start_pos": 114633955, "end_pos": 114604067, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013869", "url": "https://www.ensembl.org/id/ENSBTAG00000013869" } ] } } ], "crossref": [ { "id": "E1BB46", "url": "https://alphafold.ebi.ac.uk/entry/E1BB46", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013869", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013869", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11757", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11757", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "520462", "url": "https://www.ncbi.nlm.nih.gov/gene/520462", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000906", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000906", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035456", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035456", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056183", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056183", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520462", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520462", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RQNKSHY", "url": "https://omabrowser.org/oma/group/RQNKSHY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BB46", "url": "https://www.orthodb.org/?gene=E1BB46", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15603", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15603", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15603:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15603:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00791", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00791", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23637", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23637", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23640", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23640", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24094", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24094", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9639288", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9639288", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001137560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137560", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPS2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPS2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPS2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB46", "url": "https://www.uniprot.org/uniprotkb/E1BB46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB46-1", "url": "https://www.uniprot.org/uniprotkb/E1BB46-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAQRIRAANSSGLPRCKSEGTLIDLSEGFSESSFNDVKVPSPSALLVDNPTPFGNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLNYRNSTLSDSGMIDNLPDSPDEVAKELDLLGGWTDAKKESSKPYSNNPFWNGVQTNPFLNGNVPAMPSVDELMPRSAVDLLLFDTGTSSFTESSSATTNSTGNIFDELPAAGRLPTEPPVKRDNPFFRSKRSYSLSELSVLQAKSDAPASSGFFTGLKSPAPEQFQSREDFRAAWLSHRKLARSCHDLDLLGQSPGWGQTQAVETNIVCKLDSSGGAVQLPDANISIHVPEGHVAPGEMQQISMKALLDPPLELNSDRCSSISPVLEVKLSTLEVKTHLILEMKVSAEVKSDIFSKSTVGLQCLRSDSKEGPYVPIPLAYSYGDTVQVQLDNLEPCMYLAIVAHGPNILYPSTVWDFINKKVTVGLYGPKHIHPSFKTVVTIFGHDCAPKTLLVSEVTRQAPTPAPVALQLWGKHQFVLSRPQDLQVCVFSNMTNYEVKASEQAKAVRGFQVKLGKVSRLIFPITCQNPSELSDFTLRVQVKDDQEAILTQFCVQTPQPPPKSAIKPSGQRRFLKKNEVGKIILSPLAATTKYPTFQDRPVSSLKFGKLLKTVVRQSKNHYLLEYKKGDAIALLSEEKIRLKGQLWTKEWYIGYHQGRVGLVHAKNVLVVGKARPSLLAGPELSTSVLLEQILRPCKFLTYIYASVRTLLMENVSSWRSFADALGYGDLPLTFFCRAELDSEPERVASVLEKLKEDCNNTDNKDRKSFQKELMMALLKMDCQGLVVRLIQDFVLLTTAVEVAQRWRELAEKLAKVSKQQMDAYESPHRDRNGVVDSEAMWKPAYDFLLTWSHQIGDSYRDVIQELHIGLDKMKNPITKRWKHLTGTLILVNSLDILRASAFSPVDHDDFVI", "length": 963, "header": "tr|E1BB46-1|E1BB46_BOVIN Isoform 1 of SH3 domain-binding protein 4 OS=Bos taurus OX=9913 GN=SH3BP4 PE=4 SV=1 CANONICAL=E1BB46-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MPS2-1", "url": "https://www.uniprot.org/uniprotkb/E1BB46/entry#A0A3Q1MPS2-1", "sequence": { "sequence": "MPSPSALLVDNPTPFGNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLNYRNSTLSDSGMIDNLPDSPDEVAKELDLLGGWTDAKKESSKPYSNNPFWNGVQTNPFLNGNVPAMPSVDELMPRSAVDLLLFDTGTSSFTESSSATTNSTGNIFDELPAAGRLPTEPPVKRDNPFFRSKRSYSLSELSVLQAKSDAPASSGFFTGLKSPAPEQFQSREDFRAAWLSHRKLARSCHDLDLLGQSPGWGQTQAVETNIVCKLDSSGGAVQLPDANISIHVPEGHVAPGEMQQISMKALLDPPLELNSDRCSSISPVLEVKLSTLEVKTHLILEMKVSAEVKSDIFSKSTVGLQCLRSDSKEGPYVPIPLAYSYGDTVQVQLDNLEPCMYLAIVAHGPNILYPSTVWDFINKKVTVGLYGPKHIHPSFKTVVTIFGHDCAPKTLLVSEVTRQAPTPAPVALQLWGKHQFVLSRPQDLQVCVFSNMTNYEVKASEQAKAVRGFQVKLGKVSRLIFPITCQNPSELSDFTLRVQVKDDQEAILTQFCVQTPQPPPKSAIKPSGQRRFLKKNEVGKIILSPLAATTKYPTFQDRPVSSLKFGKLLKTVVRQSKNHYLLEYKKGDAIALLSEEKIRLKGQLWTKEWYIGYHQGRVGLVHAKNVLVVGKARPSLLAGPELSTSVLLEQILRPCKFLTYIYASVRTLLMENVSSWRSFADALGYGDLPLTFFCRAELDSEPERVASVLEKLKEDCNNTDNKDRKSFQKELMMALLKMDCQGLVVRLIQDFVLLTTAVEVAQRWRELAEKLAKVSKQQMDAYESPHRDRNGVVDSEAMWKPAYDFLLTWSHQIGDSYRDVIQELHIGLDKMKNPITKRWKHLTGTLILVNSLDILRASAFSPVDHDDFVI", "length": 924, "header": "tr|A0A3Q1MPS2-1|E1BB46_BOVIN Computationally mapped isoform of SH3 domain-binding protein 4 OS=Bos taurus OX=9913 GN=SH3BP4 PE=4 SV=1 CANONICAL=E1BB46-1" }, "locus": { "chromosome": "3", "start_pos": 114632242, "end_pos": 114614729, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071939.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071939.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073924.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073924.2" } ] } }, { "isoform_ac": "E1BB46-1", "url": "https://www.uniprot.org/uniprotkb/E1BB46/entry#E1BB46-1", "sequence": { "sequence": "MAAQRIRAANSSGLPRCKSEGTLIDLSEGFSESSFNDVKVPSPSALLVDNPTPFGNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLNYRNSTLSDSGMIDNLPDSPDEVAKELDLLGGWTDAKKESSKPYSNNPFWNGVQTNPFLNGNVPAMPSVDELMPRSAVDLLLFDTGTSSFTESSSATTNSTGNIFDELPAAGRLPTEPPVKRDNPFFRSKRSYSLSELSVLQAKSDAPASSGFFTGLKSPAPEQFQSREDFRAAWLSHRKLARSCHDLDLLGQSPGWGQTQAVETNIVCKLDSSGGAVQLPDANISIHVPEGHVAPGEMQQISMKALLDPPLELNSDRCSSISPVLEVKLSTLEVKTHLILEMKVSAEVKSDIFSKSTVGLQCLRSDSKEGPYVPIPLAYSYGDTVQVQLDNLEPCMYLAIVAHGPNILYPSTVWDFINKKVTVGLYGPKHIHPSFKTVVTIFGHDCAPKTLLVSEVTRQAPTPAPVALQLWGKHQFVLSRPQDLQVCVFSNMTNYEVKASEQAKAVRGFQVKLGKVSRLIFPITCQNPSELSDFTLRVQVKDDQEAILTQFCVQTPQPPPKSAIKPSGQRRFLKKNEVGKIILSPLAATTKYPTFQDRPVSSLKFGKLLKTVVRQSKNHYLLEYKKGDAIALLSEEKIRLKGQLWTKEWYIGYHQGRVGLVHAKNVLVVGKARPSLLAGPELSTSVLLEQILRPCKFLTYIYASVRTLLMENVSSWRSFADALGYGDLPLTFFCRAELDSEPERVASVLEKLKEDCNNTDNKDRKSFQKELMMALLKMDCQGLVVRLIQDFVLLTTAVEVAQRWRELAEKLAKVSKQQMDAYESPHRDRNGVVDSEAMWKPAYDFLLTWSHQIGDSYRDVIQELHIGLDKMKNPITKRWKHLTGTLILVNSLDILRASAFSPVDHDDFVI", "length": 963, "header": "tr|E1BB46-1|E1BB46_BOVIN Isoform 1 of SH3 domain-binding protein 4 OS=Bos taurus OX=9913 GN=SH3BP4 PE=4 SV=1 CANONICAL=E1BB46-1" }, "locus": { "chromosome": "3", "start_pos": 114632242, "end_pos": 114611991, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018420.8", "url": "https://www.ensembl.org/id/ENSBTAT00000018420.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018420.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018420.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 515, "start_aa": "Thr", "end_pos": 515, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr515", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Sestrin2 Negatively Regulates Casein Synthesis through the SH3BP4-mTORC1 Pathway in Response to AA Depletion or Supplementation in Cow Mammary Epithelial Cells.", "journal": "Journal of agricultural and food chemistry", "date": "2019-05-01", "authors": "Luo Chaochao, Zheng Nan, Zhao Shengguo, Wang Jiaqi", "evidence": [ { "database": "RefSeq", "id": "NP_001137560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137560" } ], "reference": [ { "type": "PubMed", "id": "30969118", "url": "https://glygen.org/publication/PubMed/30969118" } ] } ], "pathway": [ { "id": "bta:520462", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520462", "resource": "KEGG Pathway" }, { "id": "R-BTA-9639288", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9639288", "resource": "Reactome", "description": "Amino acids regulate mTORC1" } ], "orthologs": [ { "uniprot_canonical_ac": "G3II06-1", "protein_name": "SH3 domain-binding protein 4", "gene_name": "Sh3bp4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAQRIRAANSSGLPRCKSEGTLIDLSEGFSETSFNDVKVPSPSALLADNPTPFGNAKEVIAIKDYCPNNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLNYRNSTLSDSGMIDNLPDSPDEVAKELDLLGGWTDDQKESGRPYSNNPFWNGVRTNPFLNGNAQPSVDELNPKSTVDLLLFDTGTSSFTESSSATTNSTGNIFDELPATNGLHVEQPVRRDNPFFRSKRSYSLSELSVLQAKSDAPETSSFFTGLKSPAPEQFQSREDFRTAWLNHRKLARSCHDLDLLGQSPGWGQTQAVETNIVCKLDSSGGSVQLPDTNISIHVPEGHVAPGETQQISMKALLDPPLELNSDRSSSVSPVVEVKLSNLEVSTLIILEMKVSAEVKGDIFSKSSVVLQCLRSDSKEGPYVPIPLTYSYGDTVQVQLDNLEPCMYLAIVAQGANILYPSTVWDFINKRVTVGLYGPKHIHPSFKTVVTIFGHDCAPKTLLVTEVTRQAPGPAPVALQLWGKHQFILSRPQDLKVCMFSNMTNYEVKAIEQAKVVRGFQMKLGKVSRLIYSIISQNPNELSDFTLRVQVRDDQDTILTQFCVQTPQPPPKSAIKPSGQRRFLKKNEVGKVILSPFVVTTKYPTFQDRPVSSLKFGKLLKTVVRQNKSHYLLEYKKGDAVALLSEERIRLKGQLWTKEWYIGYYQGKVGLVHTKNVLVVGKARPSLFSGPELSTSVLLEQILRPCKFLTYIYASVRTLLMENISSWRAFADALGYGNLPLTFFCRAELDSEAERVASVLEKLKEDCNNPDNKDRKSFQKELVMALLKMDCQGLVVRLIQDFVLLTTAVEVAPRWRELAEKLAKVSRQQMDAYESPHRDRNGVVDSEAMWKPAYDFLLTWSHQIGDSYRDVIQELHIGLDKMKNPITRRWKHLTGTLILVNSLDILRAAAFSPADHDDFVI", "length": 961 }, "evidence": [ { "id": "E1BB46", "url": "https://omabrowser.org/oma/group/E1BB46/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q921I6-1", "protein_name": "SH3 domain-binding protein 4", "gene_name": "Sh3bp4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAQRIRAANASGLPRCKSEGTLIDLSEGFSETSFNDVKVPSPSALLVDNPTPFGNAKEVIAIKDYCPNNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLNYRNSTLSDSGMIDNLPDSPEEVAKELDLLGGGWTDDQKESGRPYSNNPFWNGVRTNPFLNGNAQPSTDELNPKSTVDLLLFDTGTSSFTESSSATTNSTGNIFDELPATNGLQVEQPVKRDNPFFRSKRSYSLSELSVLQAKSDAPPTSSFFTGLKSPVPEQFQSREDFRTAWLNHRKLARSCHDLDLLGQSPGWGQTQAVETNIVCKLDSSGGSVQLPDTNISIHVPEGHVAPGETQQISMKALLDPPLDLNSDRSTSVSPVVEVKLSNLEVSTFIILEMKVSAEVKGDIFSKSTVVLQCLRSDSKEGPYVPIPLAYSYGDTIQVQLDNLEPCMYLAIVAQGPNILYPSTVWDFINKRVTVGLYGPKHIHPSFKTVVTIFGHDCAPKTLLVSEVTRQAPSPAPVALQLWGKHQFILSRPQDLRVCMFSNMTNYEVKANEQARVVRGFQMKLGKVSRLIFSVISQNPNELSDFTLRVQVKDDQDTILTQFCVQTPQPPPKSAIKPSGQRRFLKKNEVGKIILSPFVVTTKYPTFQDRPVSSLKFGKLLKTVVRQNKSHYLLEYKKGDVVALLSEERIRLKGQLWTKEWYIGYYQGKVGLVHTKNVLVVGKARPSLFSGPELSTSVLLEQILRPCKFLTYIYASVRTLLMENISSWRAFADALGYGNLPLTFFCRAELDSEPERVASVLEKLKEDCNNPDNKDRKSFQKELVMALLKMDCQGLVVRLIQDFVLLTTAVEVAQRWRELAEKLAKVSKQQMDAYESPHRDRNGVVDSEAMWKPAYDFLLTWSHQIGDSYRDVIQELHIGLDKMKNPITRRWKHLTGTLILVNSLDILRAAAFSPADHDDFVI", "length": 962 }, "evidence": [ { "id": "E1BB46", "url": "https://omabrowser.org/oma/group/E1BB46/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9JJS5-1", "protein_name": "SH3 domain-binding protein 4", "gene_name": "Sh3bp4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAQRIRAANSSGLPRCKSEGTLIDLSEGFSETSFNDVKVPSPSALLVDNPTPFGNAKEVIAIKDYCPNNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLNYRNSTLSDSGMIDNLPDSPDEVAKELDLLGGWTDDQKQSGRPYSNNPFWNGVRTNPFLNGNAQPSMDELNPKSTVDLLLFDTGTSSFTESSSATTNSTGNIFDELPATNGIHLEQPVKRDNPFFRSKRSYSLSELSVLQAKSDAPPTSSFFTGLKSPAPEQFQSREDFRTAWLNHRKLARSCHDLDLLGQSPGWGQTQAVETNIVCKLDSSGGSVQLPDTSISIHVPEGHVAPGETQQISMKALLDPPLDLNSDRSTSISPVVEVKLSNLEVSTFIILEMKVSAEVKGDIFSKSTVVLQCLRSDSKEGPYAPIPLAYSYGDTIQVQLDNLEPCMYLAIVAQGSNILYPSTVWDFIHKRVTVGLYGPKHIHPSFKTVVTIFGHDCAPKTLLVTEVTRQAPSPAPVALQLWGKHQFILSRPQDLRVCMFSNMTNYDVKSNEQAKVVRGFQMKLGKVSRLIFSVISQNPNELSDFTLRVQVKDDQDTILTQFCVQTPQPPPKSAIKPSGQRRFLKKNEVGKIILSPFVVTTKYPTFQDRPVSSLKFGKLLKTVVRQNKSHYLLEYKKGDVVALLSEERIRLKGQLWTKEWYIGYYQGKVGLVHTKNVLVVGKARPSLFSGPELSTSVLLEQILRPCKFLTYIYASVRTLLMENISSWRAFADALGYGNLPLTFFCRAELDSEPERVASVLEKLKEDCNNPDNKDRKSFQKELVMALLKMDCQGLVVRLIQDFVLLTTAVEVAQRWRELAEKLAKVSKQQMDAYESPHRDRNGVVDSEAMWKPAYDFLLTWSHQIGDSYRDVIQELHIGLDKMKNPITRRWKHLTGTLILVNSLDILRAAAFSPADHDDFVI", "length": 961 }, "evidence": [ { "id": "E1BB46", "url": "https://omabrowser.org/oma/group/E1BB46/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BB46", "url": "https://www.uniprot.org/uniprotkb/E1BB46" } ], "pmid": "" }, { "name": "clathrin-coated pit", "id": "GO:0005905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005905", "evidence": [ { "database": "UniProtKB", "id": "E1BB46", "url": "https://www.uniprot.org/uniprotkb/E1BB46" } ], "pmid": "" }, { "name": "clathrin-coated vesicle", "id": "GO:0030136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030136", "evidence": [ { "database": "UniProtKB", "id": "E1BB46", "url": "https://www.uniprot.org/uniprotkb/E1BB46" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BB46", "url": "https://www.uniprot.org/uniprotkb/E1BB46" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "E1BB46", "url": "https://www.uniprot.org/uniprotkb/E1BB46" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "E1BB46", "url": "https://www.uniprot.org/uniprotkb/E1BB46" } ], "pmid": "" }, { "name": "negative regulation of cell growth", "id": "GO:0030308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030308", "evidence": [ { "database": "UniProtKB", "id": "E1BB46", "url": "https://www.uniprot.org/uniprotkb/E1BB46" } ], "pmid": "" }, { "name": "positive regulation of autophagy", "id": "GO:0010508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010508", "evidence": [ { "database": "UniProtKB", "id": "E1BB46", "url": "https://www.uniprot.org/uniprotkb/E1BB46" } ], "pmid": "" }, { "name": "negative regulation of TOR signaling", "id": "GO:0032007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032007", "evidence": [ { "database": "UniProtKB", "id": "E1BB46", "url": "https://www.uniprot.org/uniprotkb/E1BB46" } ], "pmid": "" }, { "name": "cellular response to amino acid stimulus", "id": "GO:0071230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071230", "evidence": [ { "database": "UniProtKB", "id": "E1BB46", "url": "https://www.uniprot.org/uniprotkb/E1BB46" } ], "pmid": "" }, { "name": "protein localization to lysosome", "id": "GO:0061462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061462", "evidence": [ { "database": "UniProtKB", "id": "E1BB46", "url": "https://www.uniprot.org/uniprotkb/E1BB46" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BB46", "url": "https://www.uniprot.org/uniprotkb/E1BB46" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "E1BB46", "url": "https://www.uniprot.org/uniprotkb/E1BB46" } ], "pmid": "" }, { "name": "GDP-dissociation inhibitor activity", "id": "GO:0005092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005092", "evidence": [ { "database": "UniProtKB", "id": "E1BB46", "url": "https://www.uniprot.org/uniprotkb/E1BB46" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 10, "end_pos": 12, "annotation": "n_glycosylation_sequon" }, { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" }, { "start_pos": 336, "end_pos": 338, "annotation": "n_glycosylation_sequon" }, { "start_pos": 544, "end_pos": 546, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" }, { "start_pos": 765, "end_pos": 767, "annotation": "n_glycosylation_sequon" }, { "start_pos": 810, "end_pos": 812, "annotation": "n_glycosylation_sequon" }, { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BB46-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 963, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BB46-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BB46" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 515 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 10, "end_pos": 12 }, { "start_pos": 116, "end_pos": 118 }, { "start_pos": 211, "end_pos": 213 }, { "start_pos": 336, "end_pos": 338 }, { "start_pos": 544, "end_pos": 546 }, { "start_pos": 70, "end_pos": 72 }, { "start_pos": 765, "end_pos": 767 }, { "start_pos": 810, "end_pos": 812 }, { "start_pos": 97, "end_pos": 99 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { 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"https://www.ncbi.nlm.nih.gov/protein/NP_001192379" } ] } ], "protein_names": [ { "name": "Flap endonuclease GEN homolog 1", "type": "recommended", "evidence": [ { "id": "E1B8D0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8D0/entry#names_and_taxonomy" } ] }, { "name": "Gen homolog 1, endonuclease", "type": "synonym", "evidence": [ { "id": "NP_001192379", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192379" } ] }, { "name": "flap endonuclease GEN homolog 1", "type": "synonym", "evidence": [ { "id": "NP_001192379", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192379" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8D0", "url": "https://www.uniprot.org/uniprotkb/E1B8D0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GEN1", "url": "https://www.uniprot.org/uniprotkb/E1B8D0", "locus": { "chromosome": "11", "start_pos": 80822892, "end_pos": 80851511, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020059", "url": "https://www.ensembl.org/id/ENSBTAG00000020059" } ] } } ], "crossref": [ { "id": "E1B8D0", "url": "https://alphafold.ebi.ac.uk/entry/E1B8D0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020059", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020059", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09869", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09869", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "785690", "url": "https://www.ncbi.nlm.nih.gov/gene/785690", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006085", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006085", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006086", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006086", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008918", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008918", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036279", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036279", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785690", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785690", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CKSDRYC", "url": "https://omabrowser.org/oma/group/CKSDRYC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MQI9", "url": "https://www.orthodb.org/?gene=A0A3Q1MQI9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B8D0", "url": "https://www.orthodb.org/?gene=E1B8D0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11081", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11081", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11081:SF70", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11081:SF70", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00752", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00752", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00867", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00867", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18704", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18704", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5693568", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693568", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192379", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQI9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQI9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQI9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8D0", "url": "https://www.uniprot.org/uniprotkb/E1B8D0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8D0-1", "url": "https://www.uniprot.org/uniprotkb/E1B8D0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGVNDLWQILEPVKQHVHLHSLSGKTIAVDLSLWVCEAQTVKKMIGTVMKPHLRNLFFRISYLTLMDVKLVFVMEGEPPHLKADVISKRNQVRYGPSGKTWSQKTGRSHFKSVLKECLDMLECLGIPWVQAAGEAEAMCAYLNASGYVDGCLTNDGDAFLYGAQTVYRNFTMNTKDPHVDCYTMSSIKSKLGLNRDALVGLAILLGCDYLPKGVPGVGKEQALKLIKILKGQSLLQRFNQWSEKSCYSNSQPVLVNKLAHCSVCSHPGSSKDHERNGCKLCQTDRYCEPHDYEYRCPCEWHRTEHERQLNAVENNIKKKACSCEGFPFHEVAQEFLLNKDKLVKAVRYQRPDLLLFQRFTLEKMEWPNHYACEKLLTLLTHYDMTERKLGRRNSNQLQPIRIVKNRIRNGVHCFEIEWEKPEHYTIEDKHGELAVQTIEEESLFEAAYPEIVAIYQKQKSENKGTKQKSMKIKSKGNSLLESDEMMKVQSHMTLKPTWEIFPDQNSKLSLEISPCSASPEESISTSLNVLLLAEDAACLTAQEQLISSPRSLAMQQIKDISKSLIAESSQPSTSSHNISAVADLHLSTIDWEGTSFSKSPAISRNTFTHGLKSELETAIPDSFKNNPEQLCCEAERHTTSVNKLSCWDLQKTNPEEHLLSGISDLHLQDLPLKERVLIKSYPQNTVEPDVGLKTLSLLTVKEQCVANSTSHCPPHLSKDLGIHLQNEPRSCKVLKGDQLFQENDKSNTSVPLSVNDPGTKTSNVRTGPPNATLDRSRKAGIQIARKTVRKKSVCLDRLSSDEESVPKFGKAKSTTQKMKQSSQKHSPTQFKKNDPNKLSNPKAYIKEIEQCVQVYKTARNEEACLPDAAKEPPSFLRNHKDKDDSGTCLDSPLPLSQRLKLRFQNT", "length": 906, "header": "tr|E1B8D0-1|E1B8D0_BOVIN Isoform 1 of Flap endonuclease GEN homolog 1 OS=Bos taurus OX=9913 GN=GEN1 PE=3 SV=2 CANONICAL=E1B8D0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MQI9-1", "url": "https://www.uniprot.org/uniprotkb/E1B8D0/entry#A0A3Q1MQI9-1", "sequence": { "sequence": "MGVNDLWQILEPVKQHVHLHSLSGKTIAVDLSLWVCEAQTVKKMIGTVMKPHLRNLFFRISYLTLMDVKLVFVMEGEPPHLKADVISKRNQVRYGPSGKTWSQKTGRSHFKSVLKECLDMLECLGIPWVQAAGEAEAMCAYLNASGYVDGCLTNDGDAFLYGAQTVYRNFTMNTKDPHVDCYTMSSIKSKLGLNRDALVGLAILLGCDYLPKGVPGVGKEQALKLIKILKGQSLLQRLGQQLYCQRESSSKDHERNGCKLCQTDRYCEPHDYEYRCPCEWHRTEHERQLNAVENNIKKKACSCEGFPFHEVAQEFLLNKDKLVKAVRYQRPDLLLFQRFTLEKMEWPNHYACEKLLTLLTHYDMTERKLGRRNSNQLQPIRIVKNRIRNGVHCFEIEWEKPEHYTIEDKHGELAVQTIEEESLFEAAYPEIVAIYQKQKSENKGTKQKSMKIKSKGNSLLESDEMMKVQSHMTLKPTWEIFPDQNSKLSLEISPCSASPEESISTSLNVLLLAEDAACLTAQEQLISSPRSLAMQQIKDISKSLIAESSQPSTSSHNISAVADLHLSTIDWEGTSFSKSPAISRNTFTHGLKSELETAIPDSFKNNPEQLCCEAERHTTSVNKLSCWDLQKTNPEEHLLSGISDLHLQDLPLKERVLIKSYPQNTVEPDVGLKTLSLLTVKEQCVANSTSHCPPHLSKDLGIHLQNEPRSCKVLKGDQLFQENDKSNTSVPLSVNDPGTKTSNVRTGPPNATLDRSRKAGIQIARKTVRKKSVCLDRLSSDEESVPKFGKAKSTTQKMKQSSQKHSPTQFKKNDPNKLSNPKAYIKEIEQCVQVYKTARNEEACLPDAAKEPPSFLRNHKDKDDSGTCLDSPLPLSQRLKLRFQNT", "length": 886, "header": "tr|A0A3Q1MQI9-1|E1B8D0_BOVIN Computationally mapped isoform of Flap endonuclease GEN homolog 1 OS=Bos taurus OX=9913 GN=GEN1 PE=3 SV=2 CANONICAL=E1B8D0-1" }, "locus": { "chromosome": "11", "start_pos": 80845004, "end_pos": 80823448, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079087.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079087.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074283.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074283.2" } ] } }, { "isoform_ac": "E1B8D0-1", "url": "https://www.uniprot.org/uniprotkb/E1B8D0/entry#E1B8D0-1", "sequence": { "sequence": "MGVNDLWQILEPVKQHVHLHSLSGKTIAVDLSLWVCEAQTVKKMIGTVMKPHLRNLFFRISYLTLMDVKLVFVMEGEPPHLKADVISKRNQVRYGPSGKTWSQKTGRSHFKSVLKECLDMLECLGIPWVQAAGEAEAMCAYLNASGYVDGCLTNDGDAFLYGAQTVYRNFTMNTKDPHVDCYTMSSIKSKLGLNRDALVGLAILLGCDYLPKGVPGVGKEQALKLIKILKGQSLLQRFNQWSEKSCYSNSQPVLVNKLAHCSVCSHPGSSKDHERNGCKLCQTDRYCEPHDYEYRCPCEWHRTEHERQLNAVENNIKKKACSCEGFPFHEVAQEFLLNKDKLVKAVRYQRPDLLLFQRFTLEKMEWPNHYACEKLLTLLTHYDMTERKLGRRNSNQLQPIRIVKNRIRNGVHCFEIEWEKPEHYTIEDKHGELAVQTIEEESLFEAAYPEIVAIYQKQKSENKGTKQKSMKIKSKGNSLLESDEMMKVQSHMTLKPTWEIFPDQNSKLSLEISPCSASPEESISTSLNVLLLAEDAACLTAQEQLISSPRSLAMQQIKDISKSLIAESSQPSTSSHNISAVADLHLSTIDWEGTSFSKSPAISRNTFTHGLKSELETAIPDSFKNNPEQLCCEAERHTTSVNKLSCWDLQKTNPEEHLLSGISDLHLQDLPLKERVLIKSYPQNTVEPDVGLKTLSLLTVKEQCVANSTSHCPPHLSKDLGIHLQNEPRSCKVLKGDQLFQENDKSNTSVPLSVNDPGTKTSNVRTGPPNATLDRSRKAGIQIARKTVRKKSVCLDRLSSDEESVPKFGKAKSTTQKMKQSSQKHSPTQFKKNDPNKLSNPKAYIKEIEQCVQVYKTARNEEACLPDAAKEPPSFLRNHKDKDDSGTCLDSPLPLSQRLKLRFQNT", "length": 906, "header": "tr|E1B8D0-1|E1B8D0_BOVIN Isoform 1 of Flap endonuclease GEN homolog 1 OS=Bos taurus OX=9913 GN=GEN1 PE=3 SV=2 CANONICAL=E1B8D0-1" }, "locus": { "chromosome": "11", "start_pos": 80845004, "end_pos": 80823448, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043571.3", "url": "https://www.ensembl.org/id/ENSBTAT00000043571.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041132.2", "url": "https://www.ensembl.org/id/ENSBTAP00000041132.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:785690", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785690", "resource": "KEGG Pathway" }, { "id": "R-BTA-5693568", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693568", "resource": "Reactome", "description": "Resolution of D-loop Structures through Holliday Junction Intermediates" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AFR2-1", "protein_name": "Flap endonuclease GEN homolog 1", "gene_name": "GEN1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGVNDLWQVLEPVKQHIHLNSLAGKTIAVDLSLWVCEAQTVKKMIGTVMKPHLRNLFFRISCLTLMDVKLVFVMEGEPPKLKADVINKRNQIRYGPSGKTWSHKTGRSHFKSVLKECLDMLECLGIPWVQAAGEAEAMCAYLNANGCVDGCLTNDGDAFLYGAQTVYRNFTMNTKDPHVDCYTMSSIKNILGLDRDSLVGLAILLGCDYLPKGVPGVGKEQALKLIKTLKGQSLLQRFNQWIEESYSSNSQPLVVNKLAHCSVCSHPGSPRDHERHGCKLCKTDRFCEPHDYEYSCPCEWHQTECGRQLNAVENSIKKKACSCEGFPFHEVIQEFLLSKDKLVKEIRYRRPDLLLFQRFTLEKMEWPNHYACEKLLVLLTHYDMTERKLGRRNSNQLQPIRIVKTRIRNGVRCFEIEWEKPEHYTTEDEYGELVLQTIEEESLFEAAYPEIVAIYQKQKSEIKGKKQKSMKVKSKGNSLPESDDIMSFQSHMTLKPTCENFSKQDSKLDLETSPDSALPQKSISASLSALLLPEDARCLNTQEQLISSPRPLARQQIKAVSKSLIAESSQPSTSTHNISAIADLHLSTIDWEGTSFSNSPAISRSAFSHGLKSEPETAIPDSFKNIPEQLSYESEWCTTNVNKLLDQDLQKTVPEEHLLSGITDLHLQDLPLKERIHMKSSYPQNVEQPDVDKKTLSLLTVKEHCIADSSSKCPSHLSKDLLGICLQSETGNWKVLKGDQLFQENSKANTSTLYSVSNPIVKTSSVRTGAPNTASDHNRKANVHTAQKIVMKKSVCLDRPSSDEESVPVFGNAKSTTQKIKQSSQKHSPAQFKKNDTNKSSNPKTRIKETEQGIQAYKTPGNEENCCSSKGSLSLLQCQKEKEDSATYLDSPLPLSQRLKLRFQNT", "length": 906 }, "evidence": [ { "id": "E1B8D0", "url": "https://omabrowser.org/oma/group/E1B8D0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7JNC7-1", "protein_name": "Flap endonuclease GEN homolog 1", "gene_name": "Gen1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGVNDLWQILEPVKQHIHLQNLSGKTIAVDLSLWVCEAQTVKKMIGTVVKPHLRNLFFRISYLIQMNVKLVFVMEGEPPKLKADVISKRTQTRYGPSGKPCSQKTGRSHFKSVLRECLEMLECLGIPWVQAAGEAEAMCAYLNASGHVDGCLTNDGDAFLYGAQMVYRNFTMNTKDPHVDCYTASSIKSKLGLDRDALVGLAVLLGCDYLPKGVPGVGKEQALKLLRILKGQSLLQRFNQWIEEPCSSIPQPAAKNVAHCSVCSHPGSPKDHERNGCTFCKSDRYCEPHDYEYLCPCEWHQTKHNRQLNEIENNIKKKACSCKGFPFHEVIQEFLLNKDKMLKPIRYQRPDLLLFQRFTVQKMEWPSHYACEKLLVLLTRYDMTERKLGRKNSGQLQPIRIVRPRIRNRVRCLEIEWEKPEHYAMEDTEAGELDLLTVEEASLFEAAYPEVVAIYQKQQSETQGKKQKSKKVKPKGNSLLELDNVVSSQSLMTLKPDPVLPQESTFPSLSSLVFPESAPCLNLQEHLLPSPRHLTGKQTKDVSSFLVAECSQPRSSSHNISEIANLELSTIDWEGTSFSNSPAVQRNSLSQVLQSELESSSILPGFENTPEQCTTNNEVLGRDLQKISPEEHLLSGITGLYLQDLPLKERIHLKSSCPQYNVQTDTNLESLPLKVKSSCITDCSSGCLSNFSKKFPGIYLHKESKNLKVLDNQFLQENSTVNTSIPYSFNDKAVETSSLQVGHPNTAAPYNPKVDEKTTKNLVKKSVCLKRDSSDEESSPVSWKTKYTAPKMKHSSQKHSLAQVRDKPRNPKVDTKETKPCTKSYTTAEDEENSFSDPAKRTQSFLQYHKKDEDSAACLESPLPLCQRLKLRFQNT", "length": 876 }, "evidence": [ { "id": "E1B8D0", "url": "https://omabrowser.org/oma/group/E1B8D0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0ABK0LR08-1", "protein_name": "Flap endonuclease GEN homolog 1", "gene_name": "Gen1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGVNDLWQILEPVKQHIHLQDLCGKTIAVDLSLWVCEAQTVKKMIGTVMKPHLRNLFFRISYLTQMNVKLVFVMEGEPPKLKADVMNKRTQTRYGPSGKSRSQKTGRSHFKSVLRECLEMLECLGMPWVQAAGEAEAMCAYLNASGHVDGCLTNDGDAFLYGAQTVYRNFTMNTKDPHVDCYTVSSIKSKLGLDRDALVGLAVLLGCDYLPKGVPGVGKEQALKLLQILKGQSLLQRFNQWTEEPGYSVPQSAAKKVVHCSVCSHPGSPKDHERNGCTLCKSDRYCEPHDYEYLCPCEWHQTDHNRQLNEIENNIKKKACSCEGFPFHEVIQEFLSNKNKLLKPIRYQRPDLLLFQRFTVQKMEWPSHYACEKLLVLLTRYDMIERKLGRKTSNQLQPIRIVKPRIRNGVCCLEIEWEKPEHYSVEDTQPGGLDLLTIEEASLFEAAYPEVVAIYQKQQSETKGKKQKNIKIKPKGSHLPESDDVISSQSLITLEPISKAFPKQNPKFDLEISPDPILAQESTSPSLSSFVSPENALGLNLQEQLMPSPRTLAVKQTKDVSNFLVSECSQPSSSSHNISVITDLHLSTIDWAGTSFSNSPAVQRNTFSQDLQSEPESSAILPAFEQLSYESEQCTLSNKVSNRGLQKSGPEEHLLSSITGLHLHDLPLKERIHIKSSCPQYNVGADADLESLPLTMNHSCIAYSSSGGSSHFSKDLTGVYLQKELRNSKVLDSHFLQENFRVNTSLPYSFNDEAVKTSSLQVGLPTAAVPHNPKVDVKTKNLVKKSSVCLKRDSSDEENAAVSWKAKYTAPKLKHSSHNHSLVHDRDSTHNKHRNPKDESNETKLCTESFKIAEDEENKFSDPARNPQSFLQCHNKDEDSADCWESPLPLRQRLKLRFQNTQSRLYNT", "length": 908 }, "evidence": [ { "id": "E1B8D0", "url": "https://omabrowser.org/oma/group/E1B8D0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q17RS7-1", "protein_name": "Flap endonuclease GEN homolog 1", "gene_name": "GEN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGVNDLWQILEPVKQHIPLRNLGGKTIAVDLSLWVCEAQTVKKMMGSVMKPHLRNLFFRISYLTQMDVKLVFVMEGEPPKLKADVISKRNQSRYGSSGKSWSQKTGRSHFKSVLRECLHMLECLGIPWVQAAGEAEAMCAYLNAGGHVDGCLTNDGDTFLYGAQTVYRNFTMNTKDPHVDCYTMSSIKSKLGLDRDALVGLAILLGCDYLPKGVPGVGKEQALKLIQILKGQSLLQRFNRWNETSCNSSPQLLVTKKLAHCSVCSHPGSPKDHERNGCRLCKSDKYCEPHDYEYCCPCEWHRTEHDRQLSEVENNIKKKACCCEGFPFHEVIQEFLLNKDKLVKVIRYQRPDLLLFQRFTLEKMEWPNHYACEKLLVLLTHYDMIERKLGSRNSNQLQPIRIVKTRIRNGVHCFEIEWEKPEHYAMEDKQHGEFALLTIEEESLFEAAYPEIVAVYQKQKLEIKGKKQKRIKPKENNLPEPDEVMSFQSHMTLKPTCEIFHKQNSKLNSGISPDPTLPQESISASLNSLLLPKNTPCLNAQEQFMSSLRPLAIQQIKAVSKSLISESSQPNTSSHNISVIADLHLSTIDWEGTSFSNSPAIQRNTFSHDLKSEVESELSAIPDGFENIPEQLSCESERYTANIKKVLDEDSDGISPEEHLLSGITDLCLQDLPLKERIFTKLSYPQDNLQPDVNLKTLSILSVKESCIANSGSDCTSHLSKDLPGIPLQNESRDSKILKGDQLLQEDYKVNTSVPYSVSNTVVKTCNVRPPNTALDHSRKVDMQTTRKILMKKSVCLDRHSSDEQSAPVFGKAKYTTQRMKHSSQKHNSSHFKESGHNKLSSPKIHIKETEQCVRSYETAENEESCFPDSTKSSLSSLQCHKKENNSGTCLDSPLPLRQRLKLRFQST", "length": 908 }, "evidence": [ { "id": "E1B8D0", "url": "https://omabrowser.org/oma/group/E1B8D0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BMI4-1", "protein_name": "Flap endonuclease GEN homolog 1", "gene_name": "Gen1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGVNDLWQILEPVKQHIHLQDLSGKTIAVDLSLWVCEAQTVKKMIGTVKKPHLRNLFFRISYLTQMNVKLVFVMEGEPPMLKADVISKRTQTRYGPSGKSRSQKTGRSHFKSVLRECLEMLECLGMPWVQAAGEAEAMCAYLNASGHVDGCLTNDGDAFLYGAQTVYRNFTMNTKDPHVDCYTISSIKSKLGLDRDALVGLAVLLGCDYLPKGVPGVGKEQALKLLQIFKGQSLLQRFNQWIEDPCYSVPQSAPKKVVHCSVCSHPGSPKDHERNGCILCKSDKYCEPHDYDYLCPCEWHQTDHNRHLSEIENNIKKKACSCEGFPFHEVIQEFLLNKNKMLKPITYQRPDLLLFQRFTVQKMEWPSHYACEKLLVLLTRYDMIERKHGRKTSNQLQPIRIVKPRVRNGVHCLEIEWEKPEHYVVEDGDPGKLSLLTMEEASLFEAAYPDAVAVYQKQLSETKGRKQKSMKNKPKGSHLPEADDVINSQSLMTLKPTSKAFPKQNPKINLENSPDPILAQESTSPSLNSFVSPENAPCLNLQEQLVPSPRTLAIKQSKDVSHFLVSECSQPSSSSHDISVITDLQLSTIDWAGTSFSNSPAVQRNTFSQDLASESESSAILPDFEQLSYESEQGTSDSEGSGRDLQQSNPEEQLLSGISALHLHDLPLKERIRIKSSCPQYNVGADAGLESLPLKLKGSCIAYSSSDGSSNFSKDLTGVYLHKESRNSKVLDSRLQENCGANTSLPYSFSDKAVKTSSLQVGLPTAAIPHNPRVAVKTTKNLVMKNSVCLERDSSDEDNAPGSWKSKYTAPEMKHSSQKHSLVHVRDSTHNKLRNPKVESKETKLCNESFKTAEDEENGFSDLGRSPQSFRPCHDKDENSTASWENPLPLRQRLKLRFQNTQSGFYNT", "length": 908 }, "evidence": [ { "id": "E1B8D0", "url": "https://omabrowser.org/oma/group/E1B8D0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B8D0", "url": "https://www.uniprot.org/uniprotkb/E1B8D0" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "E1B8D0", "url": "https://www.uniprot.org/uniprotkb/E1B8D0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "E1B8D0", "url": "https://www.uniprot.org/uniprotkb/E1B8D0" } ], "pmid": "" }, { "name": "regulation of centrosome duplication", "id": "GO:0010824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010824", "evidence": [ { "database": "UniProtKB", "id": "E1B8D0", "url": "https://www.uniprot.org/uniprotkb/E1B8D0" } ], "pmid": "" }, { "name": "double-strand break repair via homologous recombination", "id": "GO:0000724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000724", "evidence": [ { "database": "UniProtKB", "id": "E1B8D0", "url": "https://www.uniprot.org/uniprotkb/E1B8D0" } ], "pmid": "" }, { "name": "replication fork processing", "id": "GO:0031297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031297", "evidence": [ { "database": "UniProtKB", "id": "E1B8D0", "url": "https://www.uniprot.org/uniprotkb/E1B8D0" } ], "pmid": "" }, { "name": "positive regulation of mitotic cell cycle spindle assembly checkpoint", "id": "GO:0090267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090267", "evidence": [ { "database": "UniProtKB", "id": "E1B8D0", "url": "https://www.uniprot.org/uniprotkb/E1B8D0" } ], "pmid": "" }, { "name": "resolution of mitotic recombination intermediates", "id": "GO:0071140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071140", "evidence": [ { "database": "UniProtKB", "id": "E1B8D0", "url": "https://www.uniprot.org/uniprotkb/E1B8D0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1B8D0", "url": "https://www.uniprot.org/uniprotkb/E1B8D0" } ], "pmid": "" }, { "name": "four-way junction DNA binding", "id": "GO:0000400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000400", "evidence": [ { "database": "UniProtKB", "id": "E1B8D0", "url": "https://www.uniprot.org/uniprotkb/E1B8D0" } ], "pmid": "" }, { "name": "crossover junction DNA endonuclease activity", "id": "GO:0008821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008821", "evidence": [ { "database": "UniProtKB", "id": "E1B8D0", "url": "https://www.uniprot.org/uniprotkb/E1B8D0" } ], "pmid": "" }, { "name": "5'-flap endonuclease activity", "id": "GO:0017108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017108", "evidence": [ { "database": "UniProtKB", "id": "E1B8D0", "url": "https://www.uniprot.org/uniprotkb/E1B8D0" } ], "pmid": "" }, { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "E1B8D0", "url": "https://www.uniprot.org/uniprotkb/E1B8D0" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "E1B8D0", "url": "https://www.uniprot.org/uniprotkb/E1B8D0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 143, "end_pos": 145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 169, "end_pos": 171, "annotation": "n_glycosylation_sequon" }, { "start_pos": 577, "end_pos": 579, "annotation": "n_glycosylation_sequon" }, { "start_pos": 707, "end_pos": 709, "annotation": "n_glycosylation_sequon" }, { "start_pos": 747, "end_pos": 749, "annotation": "n_glycosylation_sequon" }, { "start_pos": 770, "end_pos": 772, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8D0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 906, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8D0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8D0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8D0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8D0" }, { "id": "SM00485", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00485" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "XPG N-terminal", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 96, "start_aa": "Met", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B8D0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8D0" }, { "id": "SM00484", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00484" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "XPG-I", "eco_id": "ECO_0000259", "start_pos": 122, "end_pos": 193, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 143, "end_pos": 145 }, { "start_pos": 169, "end_pos": 171 }, { "start_pos": 577, "end_pos": 579 }, { "start_pos": 707, "end_pos": 709 }, { "start_pos": 747, "end_pos": 749 }, { "start_pos": 770, "end_pos": 772 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCC3-1", "uniprot_ac": "E1BCC3", "uniprot_id": "E1BCC3_BOVIN", "mass": { "chemical_mass": 46533.0, "monoisotopic_mass": 46533.0 }, "refseq": { "ac": "NP_001192514", "name": "serine/threonine-protein kinase Kist", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192514" }, "gene_names": [ { "name": "UHMK1", "type": "recommended", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "name": "UHMK1", "type": "synonym", "evidence": [ { "id": "NP_001192514", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192514" } ] } ], "protein_names": [ { "name": "Serine/threonine-protein kinase Kist", "type": "recommended", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3/entry#names_and_taxonomy" } ] }, { "name": "Kinase interacting with stathmin", "type": "synonym", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3/entry#names_and_taxonomy" } ] }, { "name": "PAM COOH-terminal interactor protein 2", "type": "synonym", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3/entry#names_and_taxonomy" } ] }, { "name": "U2AF homology motif kinase 1", "type": "synonym", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3/entry#names_and_taxonomy" } ] }, { "name": "serine/threonine-protein kinase Kist", "type": "synonym", "evidence": [ { "id": "NP_001192514", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192514" } ] } ], "function": [ { "annotation": "Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA.", "evidence": [ { "database": "UniProtKB", "id": "E1BCC3", "url": "https://www.uniprot.org/uniprotkb/E1BCC3#function" }, { "database": "UniProtKB", "id": "ARBA00057207", "url": "https://www.uniprot.org/uniprotkb/ARBA00057207#function" }, { "database": "UniProtKB", "id": "A0A3Q1MQK4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQK4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCC3", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UHMK1", "url": "https://www.uniprot.org/uniprotkb/E1BCC3", "locus": { "chromosome": "3", "start_pos": 6971345, "end_pos": 7000324, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012694", "url": "https://www.ensembl.org/id/ENSBTAG00000012694" } ] } } ], "crossref": [ { "id": "E1BCC3", "url": "https://alphafold.ebi.ac.uk/entry/E1BCC3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012694", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012694", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14020", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14020", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538770", "url": "https://www.ncbi.nlm.nih.gov/gene/538770", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538770", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538770", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VMATFYP", "url": "https://omabrowser.org/oma/group/VMATFYP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MQK4", "url": "https://www.orthodb.org/?gene=A0A3Q1MQK4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BCC3", "url": "https://www.orthodb.org/?gene=E1BCC3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46962", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46962", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46962:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46962:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9634638", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9634638", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192514", "url": 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"categories": [ "Protein" ] }, { "id": "A0AAA9TLK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLK8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCC3", "url": "https://www.uniprot.org/uniprotkb/E1BCC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCC3-1", "url": "https://www.uniprot.org/uniprotkb/E1BCC3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGTPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVVEDVKEECQKYGPVVSLLVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL", "length": 419, "header": "tr|E1BCC3-1|E1BCC3_BOVIN Isoform 1 of Serine/threonine-protein kinase Kist OS=Bos taurus OX=9913 GN=UHMK1 PE=4 SV=1 CANONICAL=E1BCC3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MQK4-1", "url": "https://www.uniprot.org/uniprotkb/E1BCC3/entry#A0A3Q1MQK4-1", "sequence": { "sequence": "MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGTPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFDVVEDVKEECQKYGPVVSLLVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL", "length": 386, "header": "tr|A0A3Q1MQK4-1|E1BCC3_BOVIN Computationally mapped isoform of Serine/threonine-protein kinase Kist OS=Bos taurus OX=9913 GN=UHMK1 PE=4 SV=1 CANONICAL=E1BCC3-1" }, "locus": { "chromosome": "3", "start_pos": 7000125, "end_pos": 6980662, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069626.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069626.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072044.1", "url": "https://www.ensembl.org/id/ENSBTAP00000072044.1" } ] } }, { "isoform_ac": "A0AAA9SCD0-1", "url": "https://www.uniprot.org/uniprotkb/E1BCC3/entry#A0AAA9SCD0-1", "sequence": { "sequence": "MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGTPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVVEDVKEECQKYGPVVSLLVPKENPGRGQTQSRRRQWHPTPVLLAGKSHGWRSLAGCSPWGR", "length": 404, "header": "tr|A0AAA9SCD0-1|E1BCC3_BOVIN Computationally mapped isoform of Serine/threonine-protein kinase Kist OS=Bos taurus OX=9913 GN=UHMK1 PE=4 SV=1 CANONICAL=E1BCC3-1" }, "locus": { "chromosome": "3", "start_pos": 7000125, "end_pos": 6971778, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105237.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105237.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081186.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081186.1" } ] } }, { "isoform_ac": "A0AAA9TLK8-1", "url": "https://www.uniprot.org/uniprotkb/E1BCC3/entry#A0AAA9TLK8-1", "sequence": { "sequence": "MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGTPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEGLC", "length": 344, "header": "tr|A0AAA9TLK8-1|E1BCC3_BOVIN Computationally mapped isoform of Serine/threonine-protein kinase Kist OS=Bos taurus OX=9913 GN=UHMK1 PE=4 SV=1 CANONICAL=E1BCC3-1" }, "locus": { "chromosome": "3", "start_pos": 7000125, "end_pos": 6980798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130878.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130878.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099315.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099315.1" } ] } }, { "isoform_ac": "E1BCC3-1", "url": "https://www.uniprot.org/uniprotkb/E1BCC3/entry#E1BCC3-1", "sequence": { "sequence": "MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGTPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVVEDVKEECQKYGPVVSLLVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL", "length": 419, "header": "tr|E1BCC3-1|E1BCC3_BOVIN Isoform 1 of Serine/threonine-protein kinase Kist OS=Bos taurus OX=9913 GN=UHMK1 PE=4 SV=1 CANONICAL=E1BCC3-1" }, "locus": { "chromosome": "3", "start_pos": 7000125, "end_pos": 6980662, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016871.4", "url": "https://www.ensembl.org/id/ENSBTAT00000016871.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016871.2", "url": "https://www.ensembl.org/id/ENSBTAP00000016871.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:538770", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538770", "resource": "KEGG Pathway" }, { "id": "R-BTA-9634638", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9634638", "resource": "Reactome", "description": "Estrogen-dependent nuclear events downstream of ESR-membrane signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2TV19-1", "protein_name": "Serine/threonine-protein kinase Kist", "gene_name": "UHMK1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGCVWGAAPPLLLEALGRLWEVQAPLGSGSSASVYRVRCCGDPRAPPGAVKEFVPPPARPGPARRPGARPPAADCAEYGFRKERAALEQLRGHRNIVTLYGVFTNHYSANGPSRCLLLELLDISVSELLLHSSNQGCSMWMIQHCARDVLEALAFLHHKGYVHADLKPRNILWSAEEECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSETECTSAVDLWSLGIVLLEMFSGMKLKHTVQSQEWKTNSSAIIDRIFASEGVVNSAIPAYHLRDLIKSMLHCDQGKRASAEKALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLSDASLQSEEEYEDILEDIREECQKYGPVVSLLIPKENPGKGQVFVEYANAGDSKAAQKMLTGKIFDGKFVVATFYPLSAYKRGYLYQNLL", "length": 427 }, "evidence": [ { "id": "E1BCC3", "url": "https://omabrowser.org/oma/group/E1BCC3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A481A2R9-1", "protein_name": "Serine/threonine-protein kinase Kist", "gene_name": "UHMK1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGTPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVVEDVKEECQKYGPVVSLLVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL", "length": 419 }, "evidence": [ { "id": "E1BCC3", "url": "https://omabrowser.org/oma/group/E1BCC3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P97343-1", "protein_name": "Serine/threonine-protein kinase Kist", "gene_name": "Uhmk1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGTPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPGRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEDEYEDVVEDVKEECQKYGPVVSLLVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL", "length": 419 }, "evidence": [ { "id": "E1BCC3", "url": "https://omabrowser.org/oma/group/E1BCC3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q63285-1", "protein_name": "Serine/threonine-protein kinase Kist", "gene_name": "Uhmk1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGTPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLVYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEDEYEDVVEDVKEECQKYGPVVSLLVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL", "length": 419 }, "evidence": [ { "id": "E1BCC3", "url": "https://omabrowser.org/oma/group/E1BCC3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8TAS1-1", "protein_name": "Serine/threonine-protein kinase Kist", "gene_name": "UHMK1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGNPGSPPGALKQFLPPGTTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPSRRIPAEMALCSPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVVEDVKEECQKYGPVVSLLVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL", "length": 419 }, "evidence": [ { "id": "E1BCC3", "url": "https://omabrowser.org/oma/group/E1BCC3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BCC3", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "E1BCC3", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1BCC3", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ], "pmid": "" }, { "name": "ribonucleoprotein complex binding", "id": "GO:0043021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043021", "evidence": [ { "database": "UniProtKB", "id": "E1BCC3", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BCC3", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BCC3", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "E1BCC3", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ], "pmid": "" }, { "name": "dendrite cytoplasm", "id": "GO:0032839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032839", "evidence": [ { "database": "UniProtKB", "id": "E1BCC3", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ], "pmid": "" }, { "name": "neuronal ribonucleoprotein granule", "id": "GO:0071598", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071598", "evidence": [ { "database": "UniProtKB", "id": "E1BCC3", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "neuron projection development", "id": "GO:0031175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031175", "evidence": [ { "database": "UniProtKB", "id": "E1BCC3", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ], "pmid": "" }, { "name": "regulation of protein export from nucleus", "id": "GO:0046825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046825", "evidence": [ { "database": "UniProtKB", "id": "E1BCC3", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "E1BCC3", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ], "pmid": "" }, { "name": "positive regulation of translational initiation", "id": "GO:0045948", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045948", "evidence": [ { "database": "UniProtKB", "id": "E1BCC3", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", 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"A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] }, { "id": "R-BTA-9632868", "name": "CDKN1B is phosphorylated in response to estrogen", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-182563" ], "output_participant_list": [ "R-BTA-9632832" ], "enzyme_list": [ "E1BCC3-1" ], "evidence": [ { "id": "R-BTA-9632868", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9632868" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-182563", "participant_name": "CDKN1B [nucleoplasm]", "crossref": [ { "id": "A6QLS3", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000018254", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000024297", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000024297", "database": "ENSEMBL", "url": "" }, { "id": "NP_001093816.1", "database": "RefSeq", "url": "" }, { "id": "27143", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-9632832", "participant_name": "phospho-CDKN1B [nucleoplasm]", "crossref": [ { "id": "ENSBTAP00000024297", "database": "ENSEMBL", "url": "" }, { "id": "NP_001093816.1", "database": "RefSeq", "url": "" }, { "id": "A6QLS3", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000018254", "database": "ENSEMBL", "url": "" }, { "id": "27143", "database": "VGNC", "url": "" }, { "id": "ENSBTAT00000024297", "database": "ENSEMBL", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": 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"uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": 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"activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": 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"evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCC3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 419, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCC3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCC3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 23, "end_pos": 304, "start_aa": "Trp", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 324, "end_pos": 399, "start_aa": "Arg", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.1", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1" }, { "id": "2.7.11.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 253, "end_pos": 255 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B8I6-1", "uniprot_ac": "E1B8I6", "uniprot_id": "E1B8I6_BOVIN", "mass": { "chemical_mass": 43167.0, "monoisotopic_mass": 43167.0 }, "refseq": { "ac": "NP_001179777", "name": "LIM/homeobox protein Lhx6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179777" }, "gene_names": [ { "name": "LHX6", "type": "recommended", "evidence": [ { "id": "E1B8I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8I6" } ] }, { "name": "LHX6", "type": "synonym", "evidence": [ { "id": "NP_001179777", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179777" } ] } ], "protein_names": [ { "name": "LIM homeobox 6", "type": "synonym", "evidence": [ { "id": "E1B8I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8I6/entry#names_and_taxonomy" } ] }, { "name": "LIM/homeobox protein Lhx6", "type": "synonym", "evidence": [ { "id": "NP_001179777", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179777" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8I6", "url": "https://www.uniprot.org/uniprotkb/E1B8I6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LHX6", "url": "https://www.uniprot.org/uniprotkb/E1B8I6", "locus": { "chromosome": "11", "start_pos": 93085035, "end_pos": 93109897, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005525", "url": "https://www.ensembl.org/id/ENSBTAG00000005525" } ] } } ], "crossref": [ { "id": "E1B8I6", "url": "https://alphafold.ebi.ac.uk/entry/E1B8I6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005525", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005525", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09380", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09380", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09382", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09382", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "541261", "url": "https://www.ncbi.nlm.nih.gov/gene/541261", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050453", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050453", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541261", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541261", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HENCAAP", "url": "https://omabrowser.org/oma/group/HENCAAP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N4R1", "url": "https://www.orthodb.org/?gene=A0A3Q1N4R1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B8I6", "url": "https://www.orthodb.org/?gene=E1B8I6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24208", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24208", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24208:SF121", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24208:SF121", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179777", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1N4R1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4R1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N4R1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4R1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9W4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9W4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9W4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9W4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8I6", "url": "https://www.uniprot.org/uniprotkb/E1B8I6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8I6-1", "url": "https://www.uniprot.org/uniprotkb/E1B8I6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYWKHENAAPALPEGCRLPAEGGPATDQVMAQPGSGCKATTRCLEGTAPPAMAQSDAEALAGGLDKDEGRASPCTPSTPSVCSPPSAASSVPSAGKNICSSCGLEILDRYLLKVNNLIWHVRCLECSVCRTSLRQQNSCYIKNKEIFCKMDYFSRFGTKCARCGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFGLVEEKVLCRIHYDTMIENLKRAAENGNGLTLEGAVPSEQDSQPKPAKRARTSFTAEQLQVMQAQFAQDNNPDAQTLQKLADMTGLSRRVIQVWFQNCRARHKKHTPQHPVPPSGAQPSRLPSALSDDIHYSPFSSPERARMVTLHGYIESQVQCGQVHCRLPYTAPPVHLKADMDGPLSNRGEKVILFQY", "length": 392, "header": "tr|E1B8I6-1|E1B8I6_BOVIN Isoform 1 of LIM homeobox 6 OS=Bos taurus OX=9913 GN=LHX6 PE=4 SV=2 CANONICAL=E1B8I6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N4R1-1", "url": "https://www.uniprot.org/uniprotkb/E1B8I6/entry#A0A3Q1N4R1-1", "sequence": { "sequence": "MYWKHENAAPALPEGCRLPAEGGPATDQVMAQPGSGCKATTRCLEGTAPPAMAQSDAEALAGGLDKDEGRASPCTPSTPSVCSPPSAASSVPSAGKNICSSCGLEILDRYLLKVNNLIWHVRCLECSVCRTSLRQQNSCYIKNKEIFCKMDYFSRFGTKCARCGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFGLVEEKVLCRIHYDTMIENLKRAAENGNGLTLEGAVPSEQDSQPKPAKRARTSFTAEQLQVMQAQFAQDNNPDAQTLQKLADMTGLSRRVIQVWFQNCRARHKKHTPQHPVPPSGAQPSRLPSALSDDIHYSPFSSPERARMVTLHGYIESHPFSVLTLPALPHLSMGDLQLSLSR", "length": 377, "header": "tr|A0A3Q1N4R1-1|E1B8I6_BOVIN Computationally mapped isoform of LIM homeobox 6 OS=Bos taurus OX=9913 GN=LHX6 PE=4 SV=1 CANONICAL=E1B8I6-1" }, "locus": { "chromosome": "11", "start_pos": 93109684, "end_pos": 93086039, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080734.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080734.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064845.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064845.1" } ] } }, { "isoform_ac": "A0AAA9S9W4-1", "url": "https://www.uniprot.org/uniprotkb/E1B8I6/entry#A0AAA9S9W4-1", "sequence": { "sequence": "MRRGLCRRNAENRGAGPVMAQPGSGCKATTRCLEGTAPPAMAQSDAEALAGGLDKDEGRASPCTPSTPSVCSPPSAASSVPSAGKNICSSCGLEILDRYLLKVNNLIWHVRCLECSVCRTSLRQQNSCYIKNKEIFCKMDYFSRFGTKCARCGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFGLVEEKVLCRIHYDTMIENLKRAAENGNGLTLEGAVPSEQDSQPKPAKRARTSFTAEQLQVMQAQFAQDNNPDAQTLQKLADMTGLSRRVIQVWFQNCRARHKKHTPQHPVPPSGAQPSRLPSALSDDIHYSPFSSPERARMVTLHGYIESHPFSVLTLPALPHLSMGDLQLSLSR", "length": 366, "header": "tr|A0AAA9S9W4-1|E1B8I6_BOVIN Computationally mapped isoform of LIM homeobox 6 OS=Bos taurus OX=9913 GN=LHX6 PE=4 SV=1 CANONICAL=E1B8I6-1" }, "locus": { "chromosome": "11", "start_pos": 93109303, "end_pos": 93086039, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109372.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109372.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080212.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080212.1" } ] } }, { "isoform_ac": "A0AAA9TLK5-1", "url": "https://www.uniprot.org/uniprotkb/E1B8I6/entry#A0AAA9TLK5-1", "sequence": { "sequence": "MYWKHENAAPALPEGCRLPAEGGPATDQAQSDAEALAGGLDKDEGRASPCTPSTPSVCSPPSAASSVPSAGKNICSSCGLEILDRYLLKVNNLIWHVRCLECSVCRTSLRQQNSCYIKNKEIFCKMDYFSRFGTKCARCGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFGLVEEKVLCRIHYDTMIENLKRAAENGNGLTLEGAVPSEQDSQPKPAKRARTSFTAEQLQVMQAQFAQDNNPDAQTLQKLADMTGLSRRVIQVWFQNCRARHKKHTPQHPVPPSGAQPSRLPSALSDDIHYSPFSSPERARMVTLHGYIESQVQCGQVHCRLPYTAPPVHLKADMDGPLSNRGEKVILFQY", "length": 368, "header": "tr|A0AAA9TLK5-1|E1B8I6_BOVIN Computationally mapped isoform of LIM homeobox 6 OS=Bos taurus OX=9913 GN=LHX6 PE=4 SV=1 CANONICAL=E1B8I6-1" }, "locus": { "chromosome": "11", "start_pos": 93109684, "end_pos": 93086098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105025.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105025.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097822.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097822.1" } ] } }, { "isoform_ac": "E1B8I6-1", "url": "https://www.uniprot.org/uniprotkb/E1B8I6/entry#E1B8I6-1", "sequence": { "sequence": "MYWKHENAAPALPEGCRLPAEGGPATDQVMAQPGSGCKATTRCLEGTAPPAMAQSDAEALAGGLDKDEGRASPCTPSTPSVCSPPSAASSVPSAGKNICSSCGLEILDRYLLKVNNLIWHVRCLECSVCRTSLRQQNSCYIKNKEIFCKMDYFSRFGTKCARCGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFGLVEEKVLCRIHYDTMIENLKRAAENGNGLTLEGAVPSEQDSQPKPAKRARTSFTAEQLQVMQAQFAQDNNPDAQTLQKLADMTGLSRRVIQVWFQNCRARHKKHTPQHPVPPSGAQPSRLPSALSDDIHYSPFSSPERARMVTLHGYIESQVQCGQVHCRLPYTAPPVHLKADMDGPLSNRGEKVILFQY", "length": 392, "header": "tr|E1B8I6-1|E1B8I6_BOVIN Isoform 1 of LIM homeobox 6 OS=Bos taurus OX=9913 GN=LHX6 PE=4 SV=2 CANONICAL=E1B8I6-1" }, "locus": { "chromosome": "11", "start_pos": 93109684, "end_pos": 93086098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007266.5", "url": "https://www.ensembl.org/id/ENSBTAT00000007266.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007266.3", "url": "https://www.ensembl.org/id/ENSBTAP00000007266.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 78, "start_aa": "Thr", "end_pos": 78, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr78", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:541261", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541261", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1A648-1", "protein_name": "LIM homeobox 6", "gene_name": "LHX6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLRSHEGGQPRGPGRGAPAGTEAGKAVYIGCPALARRMEPQPPSPALSRKVMPPEPLPKATARCLDPHGRAMSQPDGEPLPAALEKEDARSAPSTPSTPSVCSPPSSSSSSTPSAGKNVCSSCGLEILDRYLLKVNNLIWHVRCLECSVCRTSLRQQHSCYIKNKEIFCKMDYFSRFGTKCARCGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFGLVEEKVLCRIHYDTMIENLKRAAENGNGITLEGAVPSEQDSQPKPAKRARTSFTAEQLQVMQAQFAQDNNPDAQTLQKLADMTGLSRRVIQVWFQNCRARHKKHTPQHTVPPSGPPPPRIPSSLAEDIHYSPFSSPERARMVTLHGYIESQVQCGQVHCRLPYTAPPVHLKADMEGPLSNRGEKVILFQY", "length": 413 }, "evidence": [ { "id": "E1B8I6", "url": "https://omabrowser.org/oma/group/E1B8I6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZDG6-1", "protein_name": "LIM homeobox 6", "gene_name": "Lhx6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYWKHESAAPALPEGCRLPAEGGPTTDQVMAQPGSGCKATTRCLEGTAPPAMAQSDAEALAGALDKDEGRASPCTPSTPSVCSPPSAASSVPSAGKNICSSCGLEILDRYLLKVNNLIWHVRCLECSVCRTSLRQQNSCYIKNKEIYCKMDYFSRFGTKCARCGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFGLVEEKVLCRIHYDTMIENLKRAAENGNGLTLEGAVPSEQDSQPKPAKRARTSFTAEQLQVMQAQFAQDNNPDAQTLQKLADMTGLSRRVIQVWFQNCRARHKKHTPQHPVPPSGAPPSRLPSSLSDDIHYSPFSSPERARMVTLHGYIESQVQCGQVHCRLPYTAPPVHLKADMDGPLSSRGEKVILFQY", "length": 392 }, "evidence": [ { "id": "E1B8I6", "url": "https://omabrowser.org/oma/group/E1B8I6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9R1R0-1", "protein_name": "LIM/homeobox protein Lhx6", "gene_name": "Lhx6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQPGSGCKATTRCLEGTAPPAMAQSDAEALAGALDKDEGRASPCTPSTPSVCSPPSAASSVPSAGKNICSSCGLEILDRYLLKVNNLIWHVRCLECSVCRTSLRQQNSCYIKNKEIYCKMDYFSRFGTKCARCGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFGLVEEKVLCRIHYDTMIENLKRAAENGNGLTLEGAVPSEQDSQPKPAKRARTSFTAEQLQVMQAQFAQDNNPDAQTLQKLADMTGLSRRVIQVWFQNCRARHKKHTPQHPVPPSGAPPTRLPSALSDDIHYSPFSSPERARMVTLHGYIESQVQCGQVHCRLPYTAPPVHLKADLDGPLSSRGEKVILFQY", "length": 363 }, "evidence": [ { "id": "E1B8I6", "url": "https://omabrowser.org/oma/group/E1B8I6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UPM6-1", "protein_name": "LIM/homeobox protein Lhx6", "gene_name": "LHX6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQPGSGCKATTRCLEGTAPPAMAQSDAEALAGALDKDEGQASPCTPSTPSVCSPPSAASSVPSAGKNICSSCGLEILDRYLLKVNNLIWHVRCLECSVCRTSLRQQNSCYIKNKEIFCKMDYFSRFGTKCARCGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFGLVEEKVLCRIHYDTMIENLKRAAENGNGLTLEGAVPSEQDSQPKPAKRARTSFTAEQLQVMQAQFAQDNNPDAQTLQKLADMTGLSRRVIQVWFQNCRARHKKHTPQHPVPPSGAPPSRLPSALSDDIHYTPFSSPERARMVTLHGYIESQVQCGQVHCRLPYTAPPVHLKADMDGPLSNRGEKVILFQY", "length": 363 }, "evidence": [ { "id": "E1B8I6", "url": "https://omabrowser.org/oma/group/E1B8I6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1B8I6", "url": "https://www.uniprot.org/uniprotkb/E1B8I6" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1B8I6", "url": "https://www.uniprot.org/uniprotkb/E1B8I6" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1B8I6", "url": "https://www.uniprot.org/uniprotkb/E1B8I6" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "E1B8I6", "url": "https://www.uniprot.org/uniprotkb/E1B8I6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B8I6", "url": "https://www.uniprot.org/uniprotkb/E1B8I6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1B8I6", "url": "https://www.uniprot.org/uniprotkb/E1B8I6" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1B8I6", "url": "https://www.uniprot.org/uniprotkb/E1B8I6" } ], "pmid": "" }, { "name": "neuron differentiation", "id": "GO:0030182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182", "evidence": [ { "database": "UniProtKB", "id": "E1B8I6", "url": "https://www.uniprot.org/uniprotkb/E1B8I6" } ], "pmid": "" }, { "name": "forebrain neuron development", "id": "GO:0021884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021884", "evidence": [ { "database": "UniProtKB", "id": "E1B8I6", "url": "https://www.uniprot.org/uniprotkb/E1B8I6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8I6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 392, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8I6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8I6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8I6" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 246, "end_pos": 306, "start_aa": "Lys", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B8I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8I6" }, { "id": "PS50023", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50023" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LIM zinc-binding", "eco_id": "ECO_0000259", "start_pos": 97, "end_pos": 157, "start_aa": "Asn", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 78 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BA17-1", "uniprot_ac": "E1BA17", "uniprot_id": "E1BA17_BOVIN", "mass": { "chemical_mass": 192817.0, "monoisotopic_mass": 192817.0 }, "refseq": { "ac": "XP_005215776", "name": "collagen alpha-1(XIV) chain isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215776" }, "gene_names": [ { "name": "COL14A1", "type": "recommended", "evidence": [ { "id": "E1BA17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA17" } ] }, { "name": "COL14A1", "type": "synonym", "evidence": [ { "id": "XP_005215776", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215776" } ] } ], "protein_names": [ { "name": "Collagen alpha-1(XIV) chain", "type": "recommended", "evidence": [ { "id": "E1BA17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA17/entry#names_and_taxonomy" } ] }, { "name": "collagen alpha-1(XIV) chain isoform X4", "type": "synonym", "evidence": [ { "id": "XP_005215776", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215776" } ] } ], "function": [ { "annotation": "Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors.", "evidence": [ { "database": "UniProtKB", "id": "E1BA17", "url": "https://www.uniprot.org/uniprotkb/E1BA17#function" }, { "database": "UniProtKB", "id": "ARBA00053575", "url": "https://www.uniprot.org/uniprotkb/ARBA00053575#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BA17", "url": "https://www.uniprot.org/uniprotkb/E1BA17" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COL14A1", "url": "https://www.uniprot.org/uniprotkb/E1BA17", "locus": { "chromosome": "14", "start_pos": 81730570, "end_pos": 81497309, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013369", "url": "https://www.ensembl.org/id/ENSBTAG00000013369" } ] } } ], "crossref": [ { "id": "ENSBTAG00000013369", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013369", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01482", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01482", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "781493", "url": "https://www.ncbi.nlm.nih.gov/gene/781493", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048287", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048287", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050525", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050525", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24020", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24020", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24020:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24020:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00092", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00092", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1650814", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1650814", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8948216", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948216", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005215776", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215776", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1N775", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N775", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N775-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N775-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA73-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA17", "url": "https://www.uniprot.org/uniprotkb/E1BA17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA17-1", "url": "https://www.uniprot.org/uniprotkb/E1BA17-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRKTRNKMKIFHCKMQYWVFPAFFVITYLCTIVQGQVAPPTRLRYNVLSHDSIQISWKAPRGKFGGYKLLVTPASGGKTNQLNLQNTATKAIIQGLMPDQNYTVQIIAYNKDKESKPAQGQFRIKDLEKRKEPKPRVKVVDKGGENKPSVPEEEVKFFCQTPAIADIVILVDGSWSIGRFNFRLVRSFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFNTKDEVIDAVRNLPYKGGNTLTGLALNYIFENSFKPEAGARTGVSKIGILITDGKSQDDIIPPSRNLRESGVELFAIGVKNADEKELQEIASEPDSTHVYNVAEFDLMHTVVESLTRTVCSRVEEQDREIKASALATVGPPTELMTSEVTARSFMVNWTHAPGKVEKYRIVYYPTRGGKPEEVVVDGRVSSTVLRNLMSLTEYQIAVFAIYAHTASEGLRGTETTLSLPIASDLELYDVTENSLRARWNPVPGASGYLILYAPLTEGLAGDEKEVKIGETHTDIELSGLLPNTEYTVTVYAMFGEEASDPVTGQESTLPLSPPRNLRISNIGSNSARLAWDATSTKINGYRIIYNNADGTEINEVEVDPVTTFPLKGLTPLTEYTVTILSIYDEGQSEPLTGVFTTEEVPAQQYLEIDEVTPDSFRVSWHPLSADEGQHKLMWIPVYGGSTEEVVLQEDQDSYVIEGLEPGTEYEVSLLAVLDDGSESEVVTAVGTTLDSFWTEPPTTEEAPTRPVTSVFRTGIRNLVVDAETTSSLRVAWDISDSSVQQFRVTYLTAQGDPAEEVLGTIMVPGSQNTLLLKNLLSETEYKVTVTPIYDDGEGVSVSAPGKTLPPSGPQNLRVSEEWYNRLRIAWDPPSSPVKGYRIVYKPVSVAGPTLETFVGANINTILITNLLSGMDYNVKIFASQASGFSDALTGVVKTLFLGVTDLQADEVQTTSLCARWQVQRHATTYRVVLESRQDTQKQESTLGGGTNRHCFYGLQPDSEYKISVYTKLQEMEGPSVSVTAKTQSLPTQPPTFPPTIPPAKEVCRAAKADLVFMVDGSWSIGDENFNKIINFLYSTVGALDKIGADGTQVAMVQFTDDPRTEFKLNSYKTKETLLDAIKHISYKGGNTKTGKAIKHVRDSLFTAESGTRRGIPRVIVVITDGRSQDDVNKISREMQSDGYSIFAVGVADADYSELVSIGSKPSARHVFFVDDFDAFKKIEDELITFVCETASATCPLVHKDGIDLAGFKMMEMFGLVEKEFSSVEGVSMEPGTFNVYPCYQLHKDALVSQPTKYLHPEGLPSDYTISILFRILPDTPEEPFALWEILNKNSDPLVGVILDNGGKTLTYFNYDYSGDFQTVTFEGPEIRKIFYGSFHKLHIVVSKTLAKVVIDCKQVGEKAINASSNITLDGVEVLGRMVRSRGPNGNSAPFQLQMFDIVCSTSWANKDKCCELPALRDEEACPELPHACSCSEINKAALGPAGPPGGPGLRGPKGQRGDPGLKGPDGPRGETGPPGPQGPPGPQGPSGLSIQGMPGMPGEKGEKGEIGLPGPQGVPGSVGSPGRDGSPGQRGFPGKDGSSGPPGPPGPIGIPGAPGVPGVTGSMGPQGALGPPGVPGAKGERGERGDLQSQAMVRAVARQVCEQLIQSHMSRYTAILNQIPSHSSSVRTIQGPPGEPGRPGSPGTPGEQGPPGAPGFPGNAGVPGSPGERGLTGVKGEKGNPGIGTQGPRGPPGPAGPSGESRPGSPGPPGSPGPRGPPGHLGVPGPQGPSGQPGYCDPSSCSAYGVGDLVPYNDYQH", "length": 1789, "header": "tr|E1BA17-1|E1BA17_BOVIN Isoform 1 of Collagen alpha-1(XIV) chain OS=Bos taurus OX=9913 GN=COL14A1 PE=1 SV=3 CANONICAL=E1BA17-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N775-1", "url": "https://www.uniprot.org/uniprotkb/E1BA17/entry#A0A3Q1N775-1", "sequence": { "sequence": "MKIFHCKMQYWVFPAFFVITYLCTIVQGQVAPPTRLRYNVLSHDSIQISWKAPRGKFGGYKLLVTPASGGKTNQLNLQNTATKAIIQGLMPDQNYTVQIIAYNKDKESKPAQGQFRIKDLEKRKEPKPRVKVVDKGGENKPSVPEEEVKFFCQTPAIADIVILVDGSWSIGRFNFRLVRSFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFNTKDEVIDAVRNLPYKGGNTLTGLALNYIFENSFKPEAGARTGVSKIGILITDGKSQDDIIPPSRNLRESGVELFAIGVKNADEKELQEIASEPDSTHVYNVAEFDLMHTVVESLTRTVCSRVEEQDREIKASALATVGPPTELMTSEVTARSFMVNWTHAPGKVEKYRIVYYPTRGGKPEEVVVDGRVSSTVLRNLMSLTEYQIAVFAIYAHTASEGLRGTETTLSLPIASDLELYDVTENSLRARWNPVPGASGYLILYAPLTEGLAGDEKEVKIGETHTDIELSGLLPNTEYTVTVYAMFGEEASDPVTGQESTLPLSPPRNLRISNIGSNSARLAWDATSTKINGYRIIYNNADGTEINEVEVDPVTTFPLKGLTPLTEYTVTILSIYDEGQSEPLTGVFTTEEVPAQQYLEIDEVTPDSFRVSWHPLSADEGQHKLMWIPVYGGSTEEVVLQEDQDSYVIEGLEPGTEYEVSLLAVLDDGSESEVVTAVGTTLDSFWTEPPTTEEAPTRPVTSVFRTGIRNLVVDAETTSSLRVAWDISDSSVQQFRVTYLTAQGDPAEEVLGTIMVPGSQNTLLLKNLLSETEYKVTVTPIYDDGEGVSVSAPGKTLPPSGPQNLRVSEEWYNRLRIAWDPPSSPVKGYRIVYKPVSVAGPTLETFVGANINTILITNLLSGMDYNVKIFASQASGFSDALTGVVKTLFLGVTDLQADEVQTTSLCARWQVQRHATTYRVVLESRQDTQKQESTLGGGTNRHCFYGLQPDSEYKISVYTKLQEMEGPSVSVTAKTQSLPTQPPTFPPTIPPAKEVCRAAKADLVFMVDGSWSIGDENFNKIINFLYSTVGALDKIGADGTQVAMVQFTDDPRTEFKLNSYKTKETLLDAIKHISYKGGNTKTGKAIKHVRDSLFTAESGTRRGIPRVIVVITDGRSQDDVNKISREMQSDGYSIFAVGVADADYSELVSIGSKPSARHVFFVDDFDAFKKIEDELITFVCETASATCPLVHKDGIDLAGFKMMEMFGLVEKEFSSVEGVSMEPGTFNVYPCYQLHKDALVSQPTNNGHIVLNGGKTLTYFNYDYSGDFQTVTFEGPEIRKIFYGSFHKLHIVVSKTLAKVVIDCKQVGEKAINASSNITLDGVEVLGRMVRSRGPNGNSAPFQLQMFDIVCSTSWANKDKCCELPALRDEEACPELPHACSCSEINKAALGPAGPPVRGLTYLWRDLLAFQGPDGPRGETGPPGPQGPPGPQGPSGLSIQGMPVSCVSALGRGIPGAPGVPGVTGSMGPQGALGPPVSMWPQPVRTAGDLQSQAMVRAVARQVCEQLIQSHMSRYTAILNQIPSHSSSVRTIQGPPGEPGRPGSPGTPGEQGPPGAPGFPGNAGVPGSPGERGLTGVKGEKGNPGIGTQGPRGPPGPAGPSGESRPGSPGPPGSPGPRGPPGHLGVPGPQGPSGQPGYCDPSSCSAYGVGAPHPDQPEFTPVQDELEAMELWGSGI", "length": 1708, "header": "tr|A0A3Q1N775-1|E1BA17_BOVIN Computationally mapped isoform of Collagen alpha-1(XIV) chain OS=Bos taurus OX=9913 GN=COL14A1 PE=1 SV=3 CANONICAL=E1BA17-1" }, "locus": { "chromosome": "14", "start_pos": 81729603, "end_pos": 81512830, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077398.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077398.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066467.3", "url": "https://www.ensembl.org/id/ENSBTAP00000066467.3" } ] } }, { "isoform_ac": "A0AAA9TA73-1", "url": "https://www.uniprot.org/uniprotkb/E1BA17/entry#A0AAA9TA73-1", "sequence": { "sequence": "MRKTRNKMKIFHCKMQYWVFPAFFVITYLCTIVQGQVAPPTRLRYNVLSHDSIQISWKAPRGKFGGYKLLVTPASGGKTNQLNLQNTATKAIIQGLMPDQNYTVQIIAYNKDKESKPAQGQFRIKDLEKRKEPKPRVKVVDKGGENKPSVPEEEVKFFCQTPAIADIVILVDGSWSIGRFNFRLVRSFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFNTKDEVIDAVRNLPYKGGNTLTGLALNYIFENSFKPEAGARTGVSKIGILITDGKSQDDIIPPSRNLRESGVELFAIGVKNADEKELQEIASEPDSTHVYNVAEFDLMHTVVESLTRTVCSRVEEQDREIKASALATVGPPTELMTSEVTARSFMVNWTHAPGKVEKYRIVYYPTRGGKPEEVVVDGRVSSTVLRNLMSLTEYQIAVFAIYAHTASEGLRGTETTLSLPIASDLELYDVTENSLRARWNPVPGASGYLILYAPLTEGLAGDEKEVKIGETHTDIELSGLLPNTEYTVTVYAMFGEEASDPVTGQESTPA", "length": 542, "header": "tr|A0AAA9TA73-1|E1BA17_BOVIN Computationally mapped isoform of Collagen alpha-1(XIV) chain OS=Bos taurus OX=9913 GN=COL14A1 PE=1 SV=2 CANONICAL=E1BA17-1" }, "locus": { "chromosome": "14", "start_pos": 81577734, "end_pos": 81512809, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093172.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093172.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095611.2", "url": "https://www.ensembl.org/id/ENSBTAP00000095611.2" } ] } }, { "isoform_ac": "E1BA17-1", "url": "https://www.uniprot.org/uniprotkb/E1BA17/entry#E1BA17-1", "sequence": { "sequence": "MRKTRNKMKIFHCKMQYWVFPAFFVITYLCTIVQGQVAPPTRLRYNVLSHDSIQISWKAPRGKFGGYKLLVTPASGGKTNQLNLQNTATKAIIQGLMPDQNYTVQIIAYNKDKESKPAQGQFRIKDLEKRKEPKPRVKVVDKGGENKPSVPEEEVKFFCQTPAIADIVILVDGSWSIGRFNFRLVRSFLENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFNTKDEVIDAVRNLPYKGGNTLTGLALNYIFENSFKPEAGARTGVSKIGILITDGKSQDDIIPPSRNLRESGVELFAIGVKNADEKELQEIASEPDSTHVYNVAEFDLMHTVVESLTRTVCSRVEEQDREIKASALATVGPPTELMTSEVTARSFMVNWTHAPGKVEKYRIVYYPTRGGKPEEVVVDGRVSSTVLRNLMSLTEYQIAVFAIYAHTASEGLRGTETTLSLPIASDLELYDVTENSLRARWNPVPGASGYLILYAPLTEGLAGDEKEVKIGETHTDIELSGLLPNTEYTVTVYAMFGEEASDPVTGQESTLPLSPPRNLRISNIGSNSARLAWDATSTKINGYRIIYNNADGTEINEVEVDPVTTFPLKGLTPLTEYTVTILSIYDEGQSEPLTGVFTTEEVPAQQYLEIDEVTPDSFRVSWHPLSADEGQHKLMWIPVYGGSTEEVVLQEDQDSYVIEGLEPGTEYEVSLLAVLDDGSESEVVTAVGTTLDSFWTEPPTTEEAPTRPVTSVFRTGIRNLVVDAETTSSLRVAWDISDSSVQQFRVTYLTAQGDPAEEVLGTIMVPGSQNTLLLKNLLSETEYKVTVTPIYDDGEGVSVSAPGKTLPPSGPQNLRVSEEWYNRLRIAWDPPSSPVKGYRIVYKPVSVAGPTLETFVGANINTILITNLLSGMDYNVKIFASQASGFSDALTGVVKTLFLGVTDLQADEVQTTSLCARWQVQRHATTYRVVLESRQDTQKQESTLGGGTNRHCFYGLQPDSEYKISVYTKLQEMEGPSVSVTAKTQSLPTQPPTFPPTIPPAKEVCRAAKADLVFMVDGSWSIGDENFNKIINFLYSTVGALDKIGADGTQVAMVQFTDDPRTEFKLNSYKTKETLLDAIKHISYKGGNTKTGKAIKHVRDSLFTAESGTRRGIPRVIVVITDGRSQDDVNKISREMQSDGYSIFAVGVADADYSELVSIGSKPSARHVFFVDDFDAFKKIEDELITFVCETASATCPLVHKDGIDLAGFKMMEMFGLVEKEFSSVEGVSMEPGTFNVYPCYQLHKDALVSQPTKYLHPEGLPSDYTISILFRILPDTPEEPFALWEILNKNSDPLVGVILDNGGKTLTYFNYDYSGDFQTVTFEGPEIRKIFYGSFHKLHIVVSKTLAKVVIDCKQVGEKAINASSNITLDGVEVLGRMVRSRGPNGNSAPFQLQMFDIVCSTSWANKDKCCELPALRDEEACPELPHACSCSEINKAALGPAGPPGGPGLRGPKGQRGDPGLKGPDGPRGETGPPGPQGPPGPQGPSGLSIQGMPGMPGEKGEKGEIGLPGPQGVPGSVGSPGRDGSPGQRGFPGKDGSSGPPGPPGPIGIPGAPGVPGVTGSMGPQGALGPPGVPGAKGERGERGDLQSQAMVRAVARQVCEQLIQSHMSRYTAILNQIPSHSSSVRTIQGPPGEPGRPGSPGTPGEQGPPGAPGFPGNAGVPGSPGERGLTGVKGEKGNPGIGTQGPRGPPGPAGPSGESRPGSPGPPGSPGPRGPPGHLGVPGPQGPSGQPGYCDPSSCSAYGVGDLVPYNDYQH", "length": 1789, "header": "tr|E1BA17-1|E1BA17_BOVIN Isoform 1 of Collagen alpha-1(XIV) chain OS=Bos taurus OX=9913 GN=COL14A1 PE=1 SV=3 CANONICAL=E1BA17-1" }, "locus": { "chromosome": "14", "start_pos": 81728752, "end_pos": 81512809, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017783.8", "url": "https://www.ensembl.org/id/ENSBTAT00000017783.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017783.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017783.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1676, "start_aa": "Thr", "end_pos": 1676, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1676", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-1650814", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1650814", "resource": "Reactome", "description": "Collagen biosynthesis and modifying enzymes" }, { "id": "R-BTA-8948216", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948216", "resource": "Reactome", "description": "Collagen chain trimerization" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "E1BA17", "url": "https://www.uniprot.org/uniprotkb/E1BA17" } ], "pmid": "" }, { "name": "extracellular matrix organization", "id": "GO:0030198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "database": "UniProtKB", "id": "E1BA17", "url": "https://www.uniprot.org/uniprotkb/E1BA17" } ], "pmid": "" }, { "name": "tissue development", "id": "GO:0009888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009888", "evidence": [ { "database": "UniProtKB", "id": "E1BA17", "url": "https://www.uniprot.org/uniprotkb/E1BA17" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "interstitial matrix", "id": "GO:0005614", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005614", "evidence": [ { "database": "UniProtKB", "id": "E1BA17", "url": "https://www.uniprot.org/uniprotkb/E1BA17" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1393, "end_pos": 1395, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1397, "end_pos": 1399, "annotation": "n_glycosylation_sequon" }, { "start_pos": 380, "end_pos": 382, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BA17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA17" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 129, "start_aa": "Pro", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BA17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA17" }, { "id": "PS50234", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50234" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFA", "eco_id": "ECO_0000259", "start_pos": 166, "end_pos": 338, "start_aa": "Asp", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1676 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 101, "end_pos": 103 }, { "start_pos": 1393, "end_pos": 1395 }, { "start_pos": 1397, "end_pos": 1399 }, { "start_pos": 380, "end_pos": 382 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B8M5-1", "uniprot_ac": "E1B8M5", "uniprot_id": "E1B8M5_BOVIN", "mass": { "chemical_mass": 69780.0, "monoisotopic_mass": 69780.0 }, "refseq": { "ac": "XP_002690270", "name": "DBH-like monooxygenase protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690270" }, "gene_names": [ { "name": "MOXD1", "type": "recommended", "evidence": [ { "id": "E1B8M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8M5" } ] }, { "name": "MOXD1", "type": "synonym", "evidence": [ { "id": "XP_002690270", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690270" } ] } ], "protein_names": [ { "name": "DBH-like monooxygenase protein 1", "type": "recommended", "evidence": [ { "id": "E1B8M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8M5/entry#names_and_taxonomy" } ] }, { "name": "DBH-like monooxygenase protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002690270", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690270" } ] }, { "name": "Monooxygenase X", "type": "synonym", "evidence": [ { "id": "E1B8M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8M5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8M5", "url": "https://www.uniprot.org/uniprotkb/E1B8M5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MOXD1", "url": "https://www.uniprot.org/uniprotkb/E1B8M5", "locus": { "chromosome": "9", "start_pos": 70257726, "end_pos": 70355725, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019460", "url": "https://www.ensembl.org/id/ENSBTAG00000019460" } ] } } ], "crossref": [ { "id": "E1B8M5", "url": "https://alphafold.ebi.ac.uk/entry/E1B8M5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019460", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019460", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09631", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09631", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507076", "url": "https://www.ncbi.nlm.nih.gov/gene/507076", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000323", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000323", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000945", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000945", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005018", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005018", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014784", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014784", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024548", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024548", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028460", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028460", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036939", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507076", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507076", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MITGKHM", "url": "https://omabrowser.org/oma/group/MITGKHM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N9J3", "url": "https://www.orthodb.org/?gene=A0A3Q1N9J3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B8M5", "url": "https://www.orthodb.org/?gene=E1B8M5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10157", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10157", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10157:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10157:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01082", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01082", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03351", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03351", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03712", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03712", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002690270", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690270", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1N9J3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9J3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N9J3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9J3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZD1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8M5", "url": "https://www.uniprot.org/uniprotkb/E1B8M5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8M5-1", "url": "https://www.uniprot.org/uniprotkb/E1B8M5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCRWPLLLLWGLLPRAAAGGSGWPFPHRTLLDSEGKYWLSWGPRGGRLAFRLEVRTAGYVGFGFSSTGAMAAADIVVGGVARGRPYLQDYFTNANRELRKDAQQDYHLEYAMENSTHTVIEFTRELHTCDINDKSISESTVRVIWAYHHEDVGEAGPKYHESNRGTKSLRLLNPEKTSMLSTAIPYFDLVNQDVSIPNKGTTYWCQMFKIPMLQEKHHVIKVEPVIQKGHESLVHHILLYQCSSNFSDSVLDDGHECYHPNMPDAFLTCETVIFAWAIGGEGFSYPPHVGLSLGTPLDPHYVLLEVHYDNPTYKEGLIDNSGLRLFYTADIRKYDAGVIEAGLWVSLFHTIPPGLPDFRSEGHCTLECLEEALEAEKPSGIHVFAVLLHAHLAGRGIRLRHFRKGEEMRLLAYDDDFDFNFQEFQYLKEEQTILPGDNLITECRYNTKDRARMTWGGLSTRNEMCLSYLLYYPRINLTRCASIPDIMEQLQFIGVKEIYRPVTTWPFIIKSPKQYRNLSFMDAMNKFKWTKKEGLAFNKLVLSLPVNVRCSKTDNAEWSIQGMTALPPDIERPYQAEPLVCGASSTSLRGNVCLELLLSFVVLGSSLSTRSLWP", "length": 614, "header": "tr|E1B8M5-1|E1B8M5_BOVIN Isoform 1 of DBH-like monooxygenase protein 1 OS=Bos taurus OX=9913 GN=MOXD1 PE=3 SV=1 CANONICAL=E1B8M5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N9J3-1", "url": "https://www.uniprot.org/uniprotkb/E1B8M5/entry#A0A3Q1N9J3-1", "sequence": { "sequence": "MCRWPLLLLWGLLPRAAAGGSGWPFPHRTLLDSEGKYWLSWGPRGGRLAFRLEVRTAGYVGFGFSSTGAMAAADIVVGGVARGRPYLQDYFTNANRELRKDAQQDYHLEYAMENSTHTVIEFTRELHTCDINDKSISESTVRVIWAYHHEDVGEAGPKYHESNRGTKSLRLLNPEKTSMLSTAIPYFDLVNQDVSIPNKGTTYWCQMFKIPMLQEKHHVIKVEPVIQKGHESLVHHILLYQCSSNFSDSVLDDGHECYHPNMPDAFLTCETVIFAWAIGGEGFSYPPHVGLSLGTPLDPHYVLLEVHYDNPTYKEGLIDNSGLRLFYTADIRKYDAGVIEAGLWVSLFHTIPPGLPDFRSEGHCTLECLEEALEAEKPSGIHVFAVLLHAHLAGRGIRLRHFRKGEEMRLLAYDDDFDFNFQEFQYLKEEQTILPGGLSTRNEMCLSYLLYYPRINLTRCASIPDIMEQLQFIGVKEIYRPVTTWPFIIKSPKQYRNLSFMDAMNKFKWTKKEGLAFNKLVLSLPVNVRCSKTDNAEWSIQGMTALPPDIERPYQAEPLVCGASSTSLRGNVCLELLLSFVVLGSSLSTRSLWP", "length": 594, "header": "tr|A0A3Q1N9J3-1|E1B8M5_BOVIN Computationally mapped isoform of DBH-like monooxygenase protein 1 OS=Bos taurus OX=9913 GN=MOXD1 PE=3 SV=1 CANONICAL=E1B8M5-1" }, "locus": { "chromosome": "9", "start_pos": 70355526, "end_pos": 70258730, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066629.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066629.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067829.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067829.1" } ] } }, { "isoform_ac": "A0AAA9TZD1-1", "url": "https://www.uniprot.org/uniprotkb/E1B8M5/entry#A0AAA9TZD1-1", "sequence": { "sequence": "MCRWPLLLLWGLLPRAAAGGSGWPFPHRTLLDSEGKYWLSWGPRGGRLAFRLEVRTAGYVGFGFSSTGAMAAADIVVGGVARGRPYLQESTVRVIWAYHHEDVGEAGPKYHESNRGTKSLRLLNPEKTSMLSTAIPYFDLVNQDVSIPNKGTTYWCQMFKIPMLQEKHHVIKVEPVIQKGHESLVHHILLYQCSSNFSDSVLDDGHECYHPNMPDAFLTCETVIFAWAIGGEGFSYPPHVGLSLGTPLDPHYVLLEVHYDNPTYKEGLIDNSGLRLFYTADIRKYDAGVIEAGLWVSLFHTIPPGLPDFRSEGHCTLECLEEALEAEKPSGIHVFAVLLHAHLAGRGIRLRHFRKGEEMRLLAYDDDFDFNFQEFQYLKEEQTILPGDNLITECRYNTKDRARMTWGGLSTRNEMCLSYLLYYPRINLTRCASIPDIMEQLQFIGVKEIYRPVTTWPFIIKSPKQYRNLSFMDAMNKFKWTKKEGLAFNKLVLSLPVNVRCSKTDNAEWSIQGMTALPPDIERPYQAEPLVCGASSTSLRGNVCLELLLSFVVLGSSLSTRSLWP", "length": 565, "header": "tr|A0AAA9TZD1-1|E1B8M5_BOVIN Computationally mapped isoform of DBH-like monooxygenase protein 1 OS=Bos taurus OX=9913 GN=MOXD1 PE=3 SV=1 CANONICAL=E1B8M5-1" }, "locus": { "chromosome": "9", "start_pos": 70355526, "end_pos": 70258730, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120913.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120913.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102609.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102609.1" } ] } }, { "isoform_ac": "E1B8M5-1", "url": "https://www.uniprot.org/uniprotkb/E1B8M5/entry#E1B8M5-1", "sequence": { "sequence": "MCRWPLLLLWGLLPRAAAGGSGWPFPHRTLLDSEGKYWLSWGPRGGRLAFRLEVRTAGYVGFGFSSTGAMAAADIVVGGVARGRPYLQDYFTNANRELRKDAQQDYHLEYAMENSTHTVIEFTRELHTCDINDKSISESTVRVIWAYHHEDVGEAGPKYHESNRGTKSLRLLNPEKTSMLSTAIPYFDLVNQDVSIPNKGTTYWCQMFKIPMLQEKHHVIKVEPVIQKGHESLVHHILLYQCSSNFSDSVLDDGHECYHPNMPDAFLTCETVIFAWAIGGEGFSYPPHVGLSLGTPLDPHYVLLEVHYDNPTYKEGLIDNSGLRLFYTADIRKYDAGVIEAGLWVSLFHTIPPGLPDFRSEGHCTLECLEEALEAEKPSGIHVFAVLLHAHLAGRGIRLRHFRKGEEMRLLAYDDDFDFNFQEFQYLKEEQTILPGDNLITECRYNTKDRARMTWGGLSTRNEMCLSYLLYYPRINLTRCASIPDIMEQLQFIGVKEIYRPVTTWPFIIKSPKQYRNLSFMDAMNKFKWTKKEGLAFNKLVLSLPVNVRCSKTDNAEWSIQGMTALPPDIERPYQAEPLVCGASSTSLRGNVCLELLLSFVVLGSSLSTRSLWP", "length": 614, "header": "tr|E1B8M5-1|E1B8M5_BOVIN Isoform 1 of DBH-like monooxygenase protein 1 OS=Bos taurus OX=9913 GN=MOXD1 PE=3 SV=1 CANONICAL=E1B8M5-1" }, "locus": { "chromosome": "9", "start_pos": 70355526, "end_pos": 70258730, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025923.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025923.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025923.4", "url": "https://www.ensembl.org/id/ENSBTAP00000025923.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507076", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507076", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XJI6-1", "protein_name": "Monooxygenase DBH like 1", "gene_name": "MOXD1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSNESSWPPCGAQRDAAPTVPSGRALCAAFRRDGGEDGAVTTGEQKMGITAELPSLAGVGGSGLQVVLFFGFFFSSGVRGIFAFSRDFGNAKKITVSSRDYHTDENRVLKKDPQQDYHLEYAMENSTHTILAFSRELHTCDPNDKSITESTVRVIWAYHHKDLGEAGQNYHGSTRGTKSLRLLNPEKAEVSPASLSYFDLTNKDVPVPDKDTTYWCQMFKIPVQHEKHHVTKVEPLIQKDHENLVHHILLYQCSSNLNDSVLDYGHECYHPNMPDSFFTCETVIFAWAIGGEGFTYPPHVGLSIGTAADPQFVLMEVHYDNPTYTEGLIDNSGLRLFYTPVLRKYDAGVIEAGLWVSLFHNIPPGMPEFVSEGHCTLECLEEALGAERPSGIHVFAVLLHAHLAGRAIRMRHFRNGEEQKLLAYDDEFDFNFQEFQYLEEERTIMPGDNLITECHYSTTDRIRMTWGGLSTRNEMCLSYLLYYPRINLTRCASIPDIMEQLQFIGVKEIYRPVRTWPFIIKSPKQYKNLSFMDAMNKFKWSKSEGLSYNELVLKLPMNVRCSKTDNAEWSFQGMTAFPPEVERPYKTEPVICSSSSCLPCSLSLTLLFVVYVASSTIGNFGPVVQ", "length": 625 }, "evidence": [ { "id": "E1B8M5", "url": "https://omabrowser.org/oma/group/E1B8M5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6UVY6-1", "protein_name": "DBH-like monooxygenase protein 1", "gene_name": "MOXD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MCCWPLLLLWGLLPGTAAGGSGRTYPHRTLLDSEGKYWLGWSQRGSQIAFRLQVRTAGYVGFGFSPTGAMASADIVVGGVAHGRPYLQDYFTNANRELKKDAQQDYHLEYAMENSTHTIIEFTRELHTCDINDKSITDSTVRVIWAYHHEDAGEAGPKYHDSNRGTKSLRLLNPEKTSVLSTALPYFDLVNQDVPIPNKDTTYWCQMFKIPVFQEKHHVIKVEPVIQRGHESLVHHILLYQCSNNFNDSVLESGHECYHPNMPDAFLTCETVIFAWAIGGEGFSYPPHVGLSLGTPLDPHYVLLEVHYDNPTYEEGLIDNSGLRLFYTMDIRKYDAGVIEAGLWVSLFHTIPPGMPEFQSEGHCTLECLEEALEAEKPSGIHVFAVLLHAHLAGRGIRLRHFRKGKEMKLLAYDDDFDFNFQEFQYLKEEQTILPGDNLITECRYNTKDRAEMTWGGLSTRSEMCLSYLLYYPRINLTRCASIPDIMEQLQFIGVKEIYRPVTTWPFIIKSPKQYKNLSFMDAMNKFKWTKKEGLSFNKLVLSLPVNVRCSKTDNAEWSIQGMTALPPDIERPYKAEPLVCGTSSSSSLHRDFSINLLVCLLLLSCTLSTKSL", "length": 613 }, "evidence": [ { "id": "E1B8M5", "url": "https://omabrowser.org/oma/group/E1B8M5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CXI3-1", "protein_name": "DBH-like monooxygenase protein 1", "gene_name": "Moxd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MCGWPLLVLWALLPATAAGSPGRSYPHRVVLDPEGKYWLHWGRQGERLAFRLEVRTNGYVGFGFSPTGSMAAADIVVGGVAHGRPYLQDYFTNADRELEKDAQQDYHLDYAMENSTHTVIEFSRELHTCDVNDKSLTDSTVRVIWAYHHDDPGESGPKYHDLNRGTRSLRLLNPEKANVVSTVLPYFDLVNQNVPIPNKGTTYWCQMFKIPTFQEKHHVIKVEPIIERGHENLVHHILVYQCSSNFNDSVLDFGHECYHPNMPDAFLTCETVILAWGIGGEGFTYPPHVGLSLGMPLDPRYVLLEVHYDNPARRKGLIDSSGLRVFHTTDIRRYDAGVIEAGLWVSLFHTIPPGMPEFHSEGHCTLECLEEALGAEKPSGIHVFAVLLHAHLAGKGIRLRHFRKGEEMKLLAYDDDYDFNFQEFQYLREEQTILPGDNLITECRYNTKDRAVMTWGGLSTRNEMCLSYLLYYPRVNLTRCSSIPDIMEQLQFIGVKEIYRPVTTWPFIIKSPKQYRNLSFMDAMNKFKWTKKEGLSFNKLVLSLPVNVRCSKTDNAEWSIQGMTAIPPDIKRPYEAEPLVCEKAASPPLHGIFSLRLLTCALLLGSMLSSQGL", "length": 613 }, "evidence": [ { "id": "E1B8M5", "url": "https://omabrowser.org/oma/group/E1B8M5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VUY0-1", "protein_name": "MOXD1 homolog 1", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSVQDVLWIVLTVQLSFGLAYFENNQRTQDYDVDKNGSVHHKNWVRNEMMDSLGLYWLKWWINANENSIYFEVTVHTRGFAGLGFSKDGRLARADMVLMWVDDATGHPNVLDCHGALHPSSGPPLQDDTQNYDVLDGKQNGTHTILKFKRKIETCDPFDIPLSADTFKVLWSIGENDPIHGNLDWQGQSRGVKALQLFSPMFTKNSHSIEGIQKWDITVNNVTIDRSMDTLYWCKIVRLPELTGKQHIIGYEPLLSGKYERNVVHHMTLFECQSKIYSGSDPSSWDLWVRSAGTVCNSNLLTPRDWDSCSTPVAVWSLGSDGQFLPPHAGIPMGGASGVSYYMLEIHYDNPDGKESVDHSGFRIHYTPNLRTYDSGILISGVSISETQLIPPGQKKYRSVGICGPSCSSVMFPKDGIKIISGTLHSHQAGRTISLRHVRSGKELNPIIVDENYDYRHQKVHQLANETVVLPGDYLITDCSYETKYRKRPTFGGYSTKEEMCLTFITYYPKIEMSGCYSMTPVREFFEMFRVYQFYSLNMTDVENMFLYNSDYTDYSKQAKNATNKPNSGKTSKEDVIYQESLLNKLVISDPAEFHDRTFLSHLNQLPWHDPLFTKRVEQAFITGTHMTFCRVSKDSLSIPSEIIRYPEFTAYVKPPAACLNYLFTDNEELRSGSSQFFTDFTLSLLLLIQLGLQTTLL", "length": 698 }, "evidence": [ { "id": "E1B8M5", "url": "https://omabrowser.org/oma/group/E1B8M5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "E1B8M5", "url": "https://www.uniprot.org/uniprotkb/E1B8M5" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "E1B8M5", "url": "https://www.uniprot.org/uniprotkb/E1B8M5" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1B8M5", "url": "https://www.uniprot.org/uniprotkb/E1B8M5" } ], "pmid": "" }, { "name": "secretory granule membrane", "id": "GO:0030667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030667", "evidence": [ { "database": "UniProtKB", "id": "E1B8M5", "url": "https://www.uniprot.org/uniprotkb/E1B8M5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "copper ion binding", "id": "GO:0005507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005507", "evidence": [ { "database": "UniProtKB", "id": "E1B8M5", "url": "https://www.uniprot.org/uniprotkb/E1B8M5" } ], "pmid": "" }, { "name": "dopamine beta-monooxygenase activity", "id": "GO:0004500", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004500", "evidence": [ { "database": "UniProtKB", "id": "E1B8M5", "url": "https://www.uniprot.org/uniprotkb/E1B8M5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "dopamine catabolic process", "id": "GO:0042420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042420", "evidence": [ { "database": "UniProtKB", "id": "E1B8M5", "url": "https://www.uniprot.org/uniprotkb/E1B8M5" } ], "pmid": "" }, { "name": "octopamine biosynthetic process", "id": "GO:0006589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006589", "evidence": [ { "database": "UniProtKB", "id": "E1B8M5", "url": "https://www.uniprot.org/uniprotkb/E1B8M5" } ], "pmid": "" }, { "name": "norepinephrine biosynthetic process", "id": "GO:0042421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042421", "evidence": [ { "database": "UniProtKB", "id": "E1B8M5", "url": "https://www.uniprot.org/uniprotkb/E1B8M5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" }, { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" }, { "start_pos": 476, "end_pos": 478, "annotation": "n_glycosylation_sequon" }, { "start_pos": 517, "end_pos": 519, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8M5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 614, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8M5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8M5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8M5" }, { "id": "PS50836", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50836" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DOMON", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 148, "start_aa": "Gly", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 114, "end_pos": 116 }, { "start_pos": 245, "end_pos": 247 }, { "start_pos": 476, "end_pos": 478 }, { "start_pos": 517, "end_pos": 519 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BC48-1", "uniprot_ac": "E1BC48", "uniprot_id": "E1BC48_BOVIN", "mass": { "chemical_mass": 350934.0, "monoisotopic_mass": 350934.0 }, "refseq": {}, "gene_names": [ { "name": "CEP350", "type": "recommended", "evidence": [ { "id": "E1BC48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC48" } ] } ], "protein_names": [ { "name": "Centrosomal protein 350", "type": "synonym", "evidence": [ { "id": "E1BC48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC48/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BC48", "url": "https://www.uniprot.org/uniprotkb/E1BC48" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CEP350", "url": "https://www.uniprot.org/uniprotkb/E1BC48", "locus": { "chromosome": "16", "start_pos": 61334437, "end_pos": 61174442, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008082", "url": "https://www.ensembl.org/id/ENSBTAG00000008082" } ] } } ], "crossref": [ { "id": "ENSBTAG00000008082", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008082", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028750", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028750", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534896", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534896", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1ND11", "url": "https://www.orthodb.org/?gene=A0A3Q1ND11", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BC48", "url": "https://www.orthodb.org/?gene=E1BC48", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13958", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13958", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13958:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13958:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01302", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01302", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1ND11", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ND11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ND11-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ND11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC48", "url": "https://www.uniprot.org/uniprotkb/E1BC48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC48-1", "url": "https://www.uniprot.org/uniprotkb/E1BC48-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSSRSKEVPLPNPRNSQSTDTIQDITAPWDALSQTKAALRHIENKLEVAPTSTAVFDSVMDTKKSSASATRKISRKDGRYLDDSWVNAPASKFSKSRKEKSRSPLRATTLESNVKKINRVEFRDPLVSYREVHGTPSSISPSHLESKHVYCVDVNEEKPESGNRLMCSQEDRNILCCDFESSQSSAVDDTVVRFLNDRPTIDALQNSECLIKVAAAMRSDEEKPNRTKGNENTLKSSVCTMGHNIDSKVLRLTDSSPSSTSTCNSQRLDILKRRQHDVKLEKLKERIRKQWEHSEETNGQGQNLGHIDHPVMVVNVDSSVTAKVRKVATAPPAPTYKGFNPSETKIRTPDGKVWQEAEFQNMSRELYRDLALHFADDSSMKEKPAEKSREKKVVKPVRKVQKVAQLSSSECKTGSSHLISTSSWRDGQKLVKKILGPAPRIEQKERRAASSDRSGRERTTKSGGHIGRAESDPRLDVSHRHRPQNSERSRSRARSENNVKKLVPSLPDNKQEENAALNKDFLPVEIRGILDDLQLDSAAQTARQETGELQNQKSSASIQAPRSHSPIKRKPDKITANEDPPVISKKRHYDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKLLLEKSLLEEPTHQHIMQETQTRPGYQPSGESDKENKVQERPPSASSSSDMSLSEPPQPLARKDLMDPSWMQPDRLSPRLHHPQPQPLVGTAGSLLSHLLNLEHVGILHKDLESILPTRKNHNMASGPLTFTPQPYLTSPTAHPDALLKSSASQYKSKLDRIEALKATAASLSSRIESEARKLAGASINYGSVWNTECDVQRTPQEDGHWTKAISPPVKEDAEDVFSARIQKMLGTCVSHATFDDDLPGVGNLSEFKKLPEMIRPHSAISNLRMRSPGPKPEGLLAQLCKRQTDSSGSDMQVCSQDKAKMSLGSSIDSVSEGPLLSEGSLSEEEGHRDEQSPLKLTEILKEKEFCAGERNAYEPIKEFQKEAEKFLPLFGPIGGTQTKGPWEELAKGSPHSVINIFTKSYKLYGKEFEDRLEGGTSASRPLNAITTPLSSISYEDDFVSSAGSGTLTERKSALEPNIGGHSLGIQEDHSSRKSAYDLSSVDVTSQHSSGAQSAASSPSSSSKGKKGKKEKIEWLDSLTGNIQNSLVDEEKVHSGSERGSHQGKKSGTSSKLSVKDYEQTLDTDSTLEEISGHSLSVSSDKGRSQKTPTSPISPSSQKLLQFDLPGTSLERSKSSIVVTPTGFKPNATFADMNLAASRTTTEMASTPGSKRFSPAGLQHRMAAELSYLSAIEESVRQLSDVERVRGVSLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALECQRQLEETRSKAAQVHAESLQQVVKSQRDMTEVLQEATCKIATQQTETARLTTNAARQICEMAELTRTHISDAITASGAPLAALYDHQRQHAPDFVKQLRTRAETDRKSQSGSLSQSKEGTLDSKHQKFSPSYDSYSESSRYKNRDRRSSSGSSRQESPSVPSSKENEKKHHGEKMESSIDEQVQTAADDSFRSDSVPSLPDEKDSTSVATEYSLKFDESMTEDEIEEKSFRSLLPSESHRRFNMEKKRGHHDDSDEETSPEKTTLSSAKELSMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIERIRQTTIKLQEKLKSAGENKLESHSDDDTKDNKAASPAPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRAEQKEIVSETESPVPSYSQLHSESSIPEELGSPAVEYIPSESIVQEHPGSPDHSIRTEDMVFSQELESSTSPSKYSPPKSCMSVSKQESSKGSHRTGGHGRLPVKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVDQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSRDLETSPTAKPQIKMLSSTSEKPKIKSLPLHRSETAKNWKSLTDSERSRGSLESIAEHVDAALTGSERSVSEKSSSAYAKRMTELDGRTEEHFQTSPILRSSRRTRAESGDSLENVPSLSLLKELNASHRILDVSGAKAEEESSQKSEIQEVEYTKLEESAIEDACSKQSRKADVFLKLDLEQGDSSEILSRKDLPLDSINVQKDLVRLAIENLHNKETKEGQSNEDISHSPNIQSEKETHVQKNIKSRDSSWSQRLLASKEISYSEDFDVSSFKKDISAELYKDNFEVASLLSLRKDSQSCREKLQATSISRSRATSFGSDDEISECLSEKSLSIHSSVHSERLLELKSPTELMKNKERSDVEHERGVTESPSLASASLTDELLDFHIGDRVLIGNVQPGTLRFKGVTSFAKGFWAGVELDKPEGNNNGTYDGIVYFVCKEKHGIFAPPQKISHIPENFDDYVDINEDEDSYSDEQYQYYNQEQKDTEGPTSDREKDTIEYFYEKSLPSVHDTEASVDKSLKVETDNIQDIPGVLEAHIHQQNSVDSLMSSEENKDLVSDATEKVSSVVEDDTLDNTFSEELKKQQQLTEEEENLHPEVSETLSTPLLDLLAREKNQLEAQLRSSVSEEKKSKEQLETVSLLTDSLLQVFVKDTVNQLQQIKKARNEKIQLSNQELLVEDQKKVPPQGLSQNLEEQSPSVPGCFLRSELEDEKEEISSPDMCPRPESPVFGASGQEELAKRLAELEISREFLSVLGDDQDWFDEDFGLSSSHKIQKNKAEETIVPLMAEPKRAPEKPCETLLAVPHTAEEVEILVHDAAEELWKWKELGHDLHSISIPAKLLGCASKGLDIESTSKRVYKQAVFDLTKEIFEEIFAEDPNLNQPVWMKPCRINSSYFRRVKNPNNLDEIKNFIATEVLKLFSLKKEPNHKTDWQKMMKFGRKKRDRVDHILVQELHEEEAQWVNYDEDELCVKMQLADGIFETLIRDTIDVLNQISEKQGRMLLV", "length": 3118, "header": "tr|E1BC48-1|E1BC48_BOVIN Isoform 1 of Centrosomal protein 350 OS=Bos taurus OX=9913 GN=CEP350 PE=4 SV=5 CANONICAL=E1BC48-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1ND11-1", "url": "https://www.uniprot.org/uniprotkb/E1BC48/entry#A0A3Q1ND11-1", "sequence": { "sequence": "MRSSRSKEVPLPNPRNSQSTDTIQDITAPWDALSQTKAALRHIENKLEVAPTSTAVFDSVMDTKKSSASATRKISRKDGRYLDDSWVNAPASKFSKSRKEKSRSPLRATTLESNVKKINRVEFRDPLVSYREVHGTPSSISPSHLESKHVYCVDVNEEKPESGNRLMCSQEDRNILCCDFESSQSSAVDDTVVRFLNDRPTIDALQNSECLIKVAAAMRSDEEKPNRTKGNENTLKSSVCTMGHNIDSKVLRLTDSSPSSTSTCNSQRLDILKRRQHDVKLEKLKERIRKQWEHSEETNGQGQNLGHIDHPVMVVNVDSSVTAKVRKVATAPPAPTYKDDSSMKEKPAEKSREKKVVKPVRKVQKVAQLSSSECKTGSSHLISTSSWRDGQKLVKKILGPAPRIEQKERRAASSDRSGRERTTKSGGHIGRAESDPRLDVSHRHRPQNSERSRSRARSENNVKKLVPSLPDNKQEENAALNKDFLPVEIRGILDDLQLDSAAQTARQETGELQNQKSSASIQAPRSHSPIKRKPDKITANEDPPVISKKRHYDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKLLLEKSLLEEPTHQHIMQETQTRPGYQPSGESDKENKVQERPPSASSSSDMSLSEPPQPLARKDLMDPSWMQPDRLSPRLHHPQPQPLVGTAGSLLSHLLNLEHVGILHKDLESILPTRKNHNMASGPLTFTPQPYLTSPTAHPDALLKSSASQYKSKLDRIEALKATAASLSSRIESEARKLAGASINYGSVWNTECDVQRTPQEDGHWTKAISPPVKEDAEDVFSARIQKMLGTCVSHATFDDDLPGVGNLSEFKKLPEMIRPHSAISNLRMRSPGPKPEGLLAQLCKRQTDSSGSDMQVCSQDKAKMSLGSSIDSVSEGPLLSEGSLSEEEGHRDEQSPLKLTEILKEKEFCAGERNAYEPIKEFQKEAEKFLPLFGPIGGTQTKGPWEELAKGSPHSVINIFTKSYKLYGKEFEDRLEGGTSASRPLNAITTPLSSISYEDDFVSSAGSGTLTERKSALEPNIGGHSLGIQEDHSSRKSAYDLSSVDVTSQHSSGAQSAASSPSSSSKGKKGKKEKIEWLDSLTGNIQNSLVDEEKVHSGSERGSHQGKKSGTSSKLSVKDYEQTLDTDSTLEEISGHSLSVSSDKGRSQKTPTSPISPSSQKLLQFDLPGTSLERSKSSIVVTPTGFKPNATFADMNLAASRTTTEMASTPGSKRFSPAGLQHRMAAELSYLSAIEESVRQLSDVERVRGVSLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALECQRQLEETRSKAAQVHAESLQQVVKSQRDMTEVLQEATCKIATQQTETARLTTNAARQICEMAELTRTHISDAITASGAPLAALYDHQRQHAPDFVKQLRTRAETDRKSQSGSLSQSKEGTLDSKHQKFSPSYDSYSESSRYKNRDRRSSSGSSRQESPSVPSSKENEKKHHGEKMESSIDEQVQTAADDSFRSDSVPSLPDEKDSTSVATEYSLKFDESMTEDEIEEKSFRSLLPSESHRRFNMEKKRGHHDDSDEETSPEKTTLSSAKELSMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIERIRQTTIKLQEKLKSAGENKLESHSDDDTKDNKAASPAPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRAEQKEIVSETESPVPSYSQLHSESSIPEELGSPAVEYIPSESIVQEHPGSPDHSIRTEDMVFSQELESSTSPSKYSPPKSCMSVSKQESSKGSHRTGGHGRLPVKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVDQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSRDLETSPTAKPQIKMLSSTSEKPKIKSLPLHRSETAKNWKSLTDSERSRGSLESIAEHVDAALTGSERSVSEKSSSAYAKRMTELDGRTEEHFQTSPILRSSRRTRAESGDSLENVPSLSLLKELNASHRILDVSGAKAEEESSQKSEIQEVEYTKLEESAIEDACSKQSRKADVFLKLDLEQGDSSEILSRKDLPLDSINVQKDLVRLAIENLHNKETKEGQSNEDISHSPNIQSEKETHVQKNIKSRDSSWSQRLLASKEISYSEDFDVSSFKKDISAELYKDNFEVASLLSLRKDSQSCREKLQATSISRSRATSFGSDDEISECLSEKSLSIHSSVHSERLLELKSPTELMKNKERSDVEHERGVTESPSLASASLTDELLDFHIGDRVLIGNVQPGTLRFKGVTSFAKGFWAGVELDKPEGNNNGTYDGIVYFVCKEKHGIFAPPQKISHIPENFDDYVDINEDEDSYSDEQYQYYNQEQKDTEGPTSDREKDTIEYFYEKSLPSVHDTEASVDKSLKVETDNIQDIPGVLEAHIHQQNSVDSLMSSEENKDLVSDATEKVSSVVEDDTLDNTFSEELKKQQQLTEEEENLHPEVSETLSTPLLDLLAREKNQLEAQLRSSVSEEKKSKEQLETVSLLTDSLLQVFVKDTVNQLQQIKKARNEKIQLSNQELLVEDQKKVPPQGLSQNLEEQSPSVPGCFLRSELEDEKEEISSPDMCPRPESPVFGASGQEELAKRLAELEISREFLSVLGDDQDWFDEDFGLSSSHKIQKNKAEETIVPLMAEPKRAPEKPCETLLAVPHTAEEVEILVHDAAEELWKWKELGHDLHSISIPAKLLGCASKGLDIESTSKRVYKQAVFDLTKEIFEEIFAEDPNLNQPVWMKPCRINSSYFRRVKNPNNLDEIKNFIATEVLKLFSLKKEPNHKTDWQKMMKFGRKKRDRVDHILVQELHEEEAQWVNYDEDELCVKMQLADGIFETLIRDTIDVLNQISEKQGRMLLV", "length": 3080, "header": "tr|A0A3Q1ND11-1|E1BC48_BOVIN Computationally mapped isoform of Centrosomal protein 350 OS=Bos taurus OX=9913 GN=CEP350 PE=4 SV=2 CANONICAL=E1BC48-1" }, "locus": { "chromosome": "16", "start_pos": 61333433, "end_pos": 61203358, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078673.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078673.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069338.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069338.2" } ] } }, { "isoform_ac": "E1BC48-1", "url": "https://www.uniprot.org/uniprotkb/E1BC48/entry#E1BC48-1", "sequence": { "sequence": "MRSSRSKEVPLPNPRNSQSTDTIQDITAPWDALSQTKAALRHIENKLEVAPTSTAVFDSVMDTKKSSASATRKISRKDGRYLDDSWVNAPASKFSKSRKEKSRSPLRATTLESNVKKINRVEFRDPLVSYREVHGTPSSISPSHLESKHVYCVDVNEEKPESGNRLMCSQEDRNILCCDFESSQSSAVDDTVVRFLNDRPTIDALQNSECLIKVAAAMRSDEEKPNRTKGNENTLKSSVCTMGHNIDSKVLRLTDSSPSSTSTCNSQRLDILKRRQHDVKLEKLKERIRKQWEHSEETNGQGQNLGHIDHPVMVVNVDSSVTAKVRKVATAPPAPTYKGFNPSETKIRTPDGKVWQEAEFQNMSRELYRDLALHFADDSSMKEKPAEKSREKKVVKPVRKVQKVAQLSSSECKTGSSHLISTSSWRDGQKLVKKILGPAPRIEQKERRAASSDRSGRERTTKSGGHIGRAESDPRLDVSHRHRPQNSERSRSRARSENNVKKLVPSLPDNKQEENAALNKDFLPVEIRGILDDLQLDSAAQTARQETGELQNQKSSASIQAPRSHSPIKRKPDKITANEDPPVISKKRHYDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKLLLEKSLLEEPTHQHIMQETQTRPGYQPSGESDKENKVQERPPSASSSSDMSLSEPPQPLARKDLMDPSWMQPDRLSPRLHHPQPQPLVGTAGSLLSHLLNLEHVGILHKDLESILPTRKNHNMASGPLTFTPQPYLTSPTAHPDALLKSSASQYKSKLDRIEALKATAASLSSRIESEARKLAGASINYGSVWNTECDVQRTPQEDGHWTKAISPPVKEDAEDVFSARIQKMLGTCVSHATFDDDLPGVGNLSEFKKLPEMIRPHSAISNLRMRSPGPKPEGLLAQLCKRQTDSSGSDMQVCSQDKAKMSLGSSIDSVSEGPLLSEGSLSEEEGHRDEQSPLKLTEILKEKEFCAGERNAYEPIKEFQKEAEKFLPLFGPIGGTQTKGPWEELAKGSPHSVINIFTKSYKLYGKEFEDRLEGGTSASRPLNAITTPLSSISYEDDFVSSAGSGTLTERKSALEPNIGGHSLGIQEDHSSRKSAYDLSSVDVTSQHSSGAQSAASSPSSSSKGKKGKKEKIEWLDSLTGNIQNSLVDEEKVHSGSERGSHQGKKSGTSSKLSVKDYEQTLDTDSTLEEISGHSLSVSSDKGRSQKTPTSPISPSSQKLLQFDLPGTSLERSKSSIVVTPTGFKPNATFADMNLAASRTTTEMASTPGSKRFSPAGLQHRMAAELSYLSAIEESVRQLSDVERVRGVSLAQQESVSLAQIIKAQQQRHERDLALLKLKAEQEALECQRQLEETRSKAAQVHAESLQQVVKSQRDMTEVLQEATCKIATQQTETARLTTNAARQICEMAELTRTHISDAITASGAPLAALYDHQRQHAPDFVKQLRTRAETDRKSQSGSLSQSKEGTLDSKHQKFSPSYDSYSESSRYKNRDRRSSSGSSRQESPSVPSSKENEKKHHGEKMESSIDEQVQTAADDSFRSDSVPSLPDEKDSTSVATEYSLKFDESMTEDEIEEKSFRSLLPSESHRRFNMEKKRGHHDDSDEETSPEKTTLSSAKELSMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIERIRQTTIKLQEKLKSAGENKLESHSDDDTKDNKAASPAPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRAEQKEIVSETESPVPSYSQLHSESSIPEELGSPAVEYIPSESIVQEHPGSPDHSIRTEDMVFSQELESSTSPSKYSPPKSCMSVSKQESSKGSHRTGGHGRLPVKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVDQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSRDLETSPTAKPQIKMLSSTSEKPKIKSLPLHRSETAKNWKSLTDSERSRGSLESIAEHVDAALTGSERSVSEKSSSAYAKRMTELDGRTEEHFQTSPILRSSRRTRAESGDSLENVPSLSLLKELNASHRILDVSGAKAEEESSQKSEIQEVEYTKLEESAIEDACSKQSRKADVFLKLDLEQGDSSEILSRKDLPLDSINVQKDLVRLAIENLHNKETKEGQSNEDISHSPNIQSEKETHVQKNIKSRDSSWSQRLLASKEISYSEDFDVSSFKKDISAELYKDNFEVASLLSLRKDSQSCREKLQATSISRSRATSFGSDDEISECLSEKSLSIHSSVHSERLLELKSPTELMKNKERSDVEHERGVTESPSLASASLTDELLDFHIGDRVLIGNVQPGTLRFKGVTSFAKGFWAGVELDKPEGNNNGTYDGIVYFVCKEKHGIFAPPQKISHIPENFDDYVDINEDEDSYSDEQYQYYNQEQKDTEGPTSDREKDTIEYFYEKSLPSVHDTEASVDKSLKVETDNIQDIPGVLEAHIHQQNSVDSLMSSEENKDLVSDATEKVSSVVEDDTLDNTFSEELKKQQQLTEEEENLHPEVSETLSTPLLDLLAREKNQLEAQLRSSVSEEKKSKEQLETVSLLTDSLLQVFVKDTVNQLQQIKKARNEKIQLSNQELLVEDQKKVPPQGLSQNLEEQSPSVPGCFLRSELEDEKEEISSPDMCPRPESPVFGASGQEELAKRLAELEISREFLSVLGDDQDWFDEDFGLSSSHKIQKNKAEETIVPLMAEPKRAPEKPCETLLAVPHTAEEVEILVHDAAEELWKWKELGHDLHSISIPAKLLGCASKGLDIESTSKRVYKQAVFDLTKEIFEEIFAEDPNLNQPVWMKPCRINSSYFRRVKNPNNLDEIKNFIATEVLKLFSLKKEPNHKTDWQKMMKFGRKKRDRVDHILVQELHEEEAQWVNYDEDELCVKMQLADGIFETLIRDTIDVLNQISEKQGRMLLV", "length": 3118, "header": "tr|E1BC48-1|E1BC48_BOVIN Isoform 1 of Centrosomal protein 350 OS=Bos taurus OX=9913 GN=CEP350 PE=4 SV=5 CANONICAL=E1BC48-1" }, "locus": { "chromosome": "16", "start_pos": 61333433, "end_pos": 61203358, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010631.8", "url": "https://www.ensembl.org/id/ENSBTAT00000010631.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010631.8", "url": "https://www.ensembl.org/id/ENSBTAP00000010631.8" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2604, "start_aa": "Thr", "end_pos": 2604, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2604", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:534896", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534896", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "E1BC48", "url": "https://www.uniprot.org/uniprotkb/E1BC48" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BC48", "url": "https://www.uniprot.org/uniprotkb/E1BC48" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "E1BC48", "url": "https://www.uniprot.org/uniprotkb/E1BC48" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "E1BC48", "url": "https://www.uniprot.org/uniprotkb/E1BC48" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "E1BC48", "url": "https://www.uniprot.org/uniprotkb/E1BC48" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "microtubule anchoring", "id": "GO:0034453", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034453", "evidence": [ { "database": "UniProtKB", "id": "E1BC48", "url": "https://www.uniprot.org/uniprotkb/E1BC48" } ], "pmid": "" }, { "name": "protein localization to centrosome", "id": "GO:0071539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071539", "evidence": [ { "database": "UniProtKB", "id": "E1BC48", "url": "https://www.uniprot.org/uniprotkb/E1BC48" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1297, "end_pos": 1299, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2238, "end_pos": 2240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 226, "end_pos": 228, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2541, "end_pos": 2543, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3006, "end_pos": 3008, "annotation": "n_glycosylation_sequon" }, { "start_pos": 362, "end_pos": 364, "annotation": "n_glycosylation_sequon" }, { "start_pos": 914, "end_pos": 916, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BC48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC48" }, { "id": "PS50245", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50245" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CAP-Gly", "eco_id": "ECO_0000259", "start_pos": 2519, "end_pos": 2561, "start_aa": "Gly", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 2604 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1297, "end_pos": 1299 }, { "start_pos": 2238, "end_pos": 2240 }, { "start_pos": 226, "end_pos": 228 }, { "start_pos": 2541, "end_pos": 2543 }, { "start_pos": 3006, "end_pos": 3008 }, { "start_pos": 362, "end_pos": 364 }, { "start_pos": 914, "end_pos": 916 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BA93-1", "uniprot_ac": "E1BA93", "uniprot_id": "E1BA93_BOVIN", "mass": { "chemical_mass": 120143.0, "monoisotopic_mass": 120143.0 }, "refseq": { "ac": "XP_015327788", "name": "synaptopodin isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327788" }, "gene_names": [ { "name": "SYNPO", "type": "recommended", "evidence": [ { "id": "E1BA93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA93" } ] }, { "name": "SYNPO", "type": "synonym", "evidence": [ { "id": "XP_015327788", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327788" } ] } ], "protein_names": [ { "name": "Synaptopodin", "type": "synonym", "evidence": [ { "id": "E1BA93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA93/entry#names_and_taxonomy" } ] }, { "name": "synaptopodin isoform X1", "type": "synonym", "evidence": [ { "id": "XP_015327788", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327788" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BA93", "url": "https://www.uniprot.org/uniprotkb/E1BA93" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SYNPO", "url": "https://www.uniprot.org/uniprotkb/E1BA93", "locus": { "chromosome": "7", "start_pos": 62027835, "end_pos": 61990291, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013744", "url": "https://www.ensembl.org/id/ENSBTAG00000013744" } ] } } ], "crossref": [ { "id": "E1BA93", "url": "https://alphafold.ebi.ac.uk/entry/E1BA93", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013744", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013744", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533531", "url": "https://www.ncbi.nlm.nih.gov/gene/533531", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR051976", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051976", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HMSRKTN", "url": "https://omabrowser.org/oma/group/HMSRKTN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BA93", "url": "https://www.orthodb.org/?gene=E1BA93", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24217", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24217", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24217:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24217:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_015327788", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327788", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RS47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RS47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RS47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RS47-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA93", "url": "https://www.uniprot.org/uniprotkb/E1BA93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA93-1", "url": "https://www.uniprot.org/uniprotkb/E1BA93-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGPHLPPLPPAPSEGGSTPCAFGVPDGSYRCLALEAEESGGEEGLQGEAGLTDLEEDQVASRSGDKTCRATQGPPQLPRALGTQPPSCSREARGVSQLDNRASQAGDPVKFRQVMTASLSPSPGPRVAQKPALGRSTSLTEKDLKEAKARSQQIAAQLTTPPSSNSRGVQLFNRRRQRVNEFTLESHGQRGPKSSQEPLRVPPASPTGHAPGLSLSSTSLPEPGPPRNPACQSADTGVPSHSMEGCSEEASLLRHLEKMASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSPPTPPPEEVHSPAADANQNLPSTGTTLVTPASNGNHSLPATDVNQNLSAAITPQSLPLSSVQQNSSEVQLPPNDVVPDFKPSTQCAGGQPQEPAVEVRSSTLLIDKVSAPPTATSTFSREVTPISSSRPLGPDFMSSSLLIDVQLGAPVVSTEQEMSGRTTATTPTKLYSEVHLTLAKPPSVVNRTARPFGIQAPGSTGQMERSPMVERRHRGEKTPVPQPPSVADRSPRPQRHVISHSPMLERRPVAQRSPALERRPLGNFTPPPTYAETLSTAPLTSGVRSPPSYSALYPSSDSKPSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEAGLEEEPFALGAEASNFQQEPAPRDRASPADAEETIPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSGHAELARCPSPTMSLPSSWKYSTNTPGGTFRVASRSPARTPPASLFHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKPSPRAASPAKPSSLDLVPSLPKAALPPSPALPRPSRSYTTTGQDGLQPTAVSPTYSSDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRSETEVRPPSRQLQALLARNIINAARRKSASPRPAGAESLRPFSPPRAPPPPPPPPPPPPRMRSPQPSRPGPAAAPGATFAPIPRSPLPAPPRPFPYRRSPTDSDVSLDSEDSGAKSPGILGYNICPRGWNGSLRLKRGNLPTEASCTT", "length": 1128, "header": "tr|E1BA93-1|E1BA93_BOVIN Isoform 1 of Synaptopodin OS=Bos taurus OX=9913 GN=SYNPO PE=3 SV=3 CANONICAL=E1BA93-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RS47-1", "url": "https://www.uniprot.org/uniprotkb/E1BA93/entry#A0AAA9RS47-1", "sequence": { "sequence": "MEGCSEEASLLRHLEKMASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSPPTPPPEEVHSPAADANQNLPSTGTTLVTPASNGNHSLPATDVNQNLSAAITPQSLPLSSVQQNSSEVQLPPNDVVPDFKPSTQCAGGQPQEPAVEVRSSTLLIDKVSAPPTATSTFSREVTPISSSRPLGPDFMSSSLLIDVQLGAPVVSTEQEMSGRTTATTPTKLYSEVHLTLAKPPSVVNRTARPFGIQAPGSTGQMERSPMVERRHRGEKTPVPQPPSVADRSPRPQRHVISHSPMLERRPVAQRSPALERRPLGNFTPPPTYAETLSTAPLTSGVRSPPSYSALYPSSDSKPSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEAGLEEEPFALGAEASNFQQEPAPRDRASPADAEETIPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSGHAELARCPSPTMSLPSSWKYSTNTPGGTFRVASRSPARTPPASLFHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKPSPRAASPAKPSSLDLVPSLPKAALPPSPALPRPSRSYTTTGQDGLQPTAVSPTYSSDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRSETEVRPPSRQLQALLARNIINAARRKSASPRPAGAESLRPFSPPRAPPPPPPPPPPPPRMRSPQPSRPGPAAAPGATFAPIPRSPLPAPPRPFPYRRSPTDSDVSLDSEDSGAKSPGILGYNICPRGWNGSLRLKRGNLPTEASCTT", "length": 885, "header": "tr|A0AAA9RS47-1|E1BA93_BOVIN Computationally mapped isoform of Synaptopodin OS=Bos taurus OX=9913 GN=SYNPO PE=3 SV=2 CANONICAL=E1BA93-1" }, "locus": { "chromosome": "7", "start_pos": 62026831, "end_pos": 62018883, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133957.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133957.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075220.2", "url": "https://www.ensembl.org/id/ENSBTAP00000075220.2" } ] } }, { "isoform_ac": "E1BA93-1", "url": "https://www.uniprot.org/uniprotkb/E1BA93/entry#E1BA93-1", "sequence": { "sequence": "MLGPHLPPLPPAPSEGGSTPCAFGVPDGSYRCLALEAEESGGEEGLQGEAGLTDLEEDQVASRSGDKTCRATQGPPQLPRALGTQPPSCSREARGVSQLDNRASQAGDPVKFRQVMTASLSPSPGPRVAQKPALGRSTSLTEKDLKEAKARSQQIAAQLTTPPSSNSRGVQLFNRRRQRVNEFTLESHGQRGPKSSQEPLRVPPASPTGHAPGLSLSSTSLPEPGPPRNPACQSADTGVPSHSMEGCSEEASLLRHLEKMASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSPPTPPPEEVHSPAADANQNLPSTGTTLVTPASNGNHSLPATDVNQNLSAAITPQSLPLSSVQQNSSEVQLPPNDVVPDFKPSTQCAGGQPQEPAVEVRSSTLLIDKVSAPPTATSTFSREVTPISSSRPLGPDFMSSSLLIDVQLGAPVVSTEQEMSGRTTATTPTKLYSEVHLTLAKPPSVVNRTARPFGIQAPGSTGQMERSPMVERRHRGEKTPVPQPPSVADRSPRPQRHVISHSPMLERRPVAQRSPALERRPLGNFTPPPTYAETLSTAPLTSGVRSPPSYSALYPSSDSKPSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEAGLEEEPFALGAEASNFQQEPAPRDRASPADAEETIPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSGHAELARCPSPTMSLPSSWKYSTNTPGGTFRVASRSPARTPPASLFHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKPSPRAASPAKPSSLDLVPSLPKAALPPSPALPRPSRSYTTTGQDGLQPTAVSPTYSSDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRSETEVRPPSRQLQALLARNIINAARRKSASPRPAGAESLRPFSPPRAPPPPPPPPPPPPRMRSPQPSRPGPAAAPGATFAPIPRSPLPAPPRPFPYRRSPTDSDVSLDSEDSGAKSPGILGYNICPRGWNGSLRLKRGNLPTEASCTT", "length": 1128, "header": "tr|E1BA93-1|E1BA93_BOVIN Isoform 1 of Synaptopodin OS=Bos taurus OX=9913 GN=SYNPO PE=3 SV=3 CANONICAL=E1BA93-1" }, "locus": { "chromosome": "7", "start_pos": 62026831, "end_pos": 61990490, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018267.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018267.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018267.4", "url": "https://www.ensembl.org/id/ENSBTAP00000018267.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 299, "start_aa": "Thr", "end_pos": 299, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr299", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 754, "start_aa": "Thr", "end_pos": 754, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr754", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 928, "start_aa": "Thr", "end_pos": 928, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr928", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YQQ2-1", "protein_name": "Synaptopodin", "gene_name": "SYNPO", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLKAPLRQESDRGDIPDPELPTGNVNNEPAAPPDCCAPSPAPQLPPTAVSPMDDPSQEWRLVKIKRVLIAPSTEPRKASLSRSSSLSEKELKEAKARSRRIVAQLTTAPGPSSKGVLLFHRRRQRVDGLTGTGTGHGTGLPLSLGAQPGDMETGEGHSSRGTLGEQEDVASRQESPTEAQQVPLSIYLKENMALAAANGVHKEKVESEVGGVQGTGDSLGTRVATPAPPESACVPKQKNGEVPSVPVVTANTPVGTASTSLGTVSMPTGTASMTMGTAGTPLGTDSVSMGTVTMPVVTANMTVRRAGTPIGMAGTPVVTASAPVVTASIPAGVAMANTAMGTASEPMVSANITTGTPSAPMVTASVPTGAASMPVGTASTHIVTTSVPMGTASSHTVAANIPMGMADAAMGTANAPMGTASPPTVTSNAPVVTSNIPTVTASTPPGTAPPATQAQSRAQSRQYYEVHLTLAKPKPVKNRTARPFGTQTPPGLSQPPERAPGTEPPPPTYAETLGSPPPLSRVRSPPTYSALYPPGEQKAPSGPSYGLAAVVPLPKTGILEESAARRGHKKSMFTFVEKPKLGPNPDLLDLVQSADIRKKQKEHGDPGAEDEPFALGAEAANFVPASASRAAQPLPVPDDAPAWSSCLKSPMVKPKPKPQPSHNLSEARGKGAELFARRQSRMEKFIIEAPSQPELLRSPSPTMSLPPSWKYDANACLSPMVSRHPTRSPSQPSKTPPASLYGNNPTENEAELSKHQPYQLQPSLFILSPSKAPARSMPPPRPSPPSTYSYPQQTSCPTSPLPPSPIWQPPTTHGAASSPFLSATGALPMTHSAGGGGAELLLASPCHGRSPRAKGGFQAPRPSYSTRNAGIEPQERRPSLPASPTWTPRLARHQGAQDGWASPVSVPELEQGPPRSPPWSERSLSPQRQDAEPRASRQMQARLARNIINAARRKSSSPKPPGPDGSRPFTPPAVGPPGLPQGCKAAAPQRARSVPAAPGSPSPSHRSPLTEGPCASPGVSRATWAEGRRLLLPPSPAGPSPTPKSPLPSPVVGARSPAKRYSSRSPTDSDVSIDSEDSGTKSPGIHSFNLCPRGWSGSLRLKAGGLPSGAHCTS", "length": 1114 }, "evidence": [ { "id": "E1BA93", "url": "https://omabrowser.org/oma/group/E1BA93/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8CC35-1", "protein_name": "Synaptopodin", "gene_name": "Synpo", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLGAHFPPPPLGASEGRAAPCTFQIPDGSYRCLALEAEESSSEDGLQGEVRLVDLEEEGTSQSRANHGTPPLSRAPAIIQPSSCHREARGGFQRSDRPSHDWDVVQARKVMTASGSSSPVPRVAQKPALGRSTSFTENDLKEAKARSQQIAAQLTTPPSSNSRGVQLFNRRRQRVNEFTLESRGQRSPKLNQEALQTGRPLSPIGHAPGPSVKPTSPSKPGSPKHPSPQSPSRGVAGHIMEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQSRETQQSSPNPPDTEVPSPAADINQNPSSPNATLTTLASSSHHSQPTADINQNPPAAITPVPQNSSQAQCSPNGTLDSKPGTLCADDGQSPVPAEEVRSSILLIDKVSAPPSAASTFSREATPLSSSGPPAADLMSSSLLIDMQPSTLVAPAEQEVPGHVAVTTPTKVYSEVHLTLAKPASVVNRTARPFGIQSPGTSQIEQSPMMGRRQFGEKAWAPPASSMADRSPQPQRHIMSRSPMVERRLLGQRSPVLERRPLGNFTPPPTYAETLSTAPVASRVRSPPSYSTLYPSSDPKPSHLKGQVAPANKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDHGEVGMEEEPFALGAEASNFQQEPIARDRASPAAAEEAVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSGHAELARCPSPTMSLPSSWKYTTNAPGGFRVASLSPARTPPASLYHGYLPENGVLRPEPTKQQPYQMRPSLYALSPVKEPAKASSRATSSRTPSRTVSPRAASPAKPSSLDLVPNLPRAGLPPSPALPRPSRSSPGLYTAPVQDSLQPTAVSPTYSSDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQVWKPSFCFK", "length": 929 }, "evidence": [ { "id": "E1BA93", "url": "https://omabrowser.org/oma/group/E1BA93/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Z327-1", "protein_name": "Synaptopodin", "gene_name": "Synpo", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLGTHFPPPPLGPSEGRAAPCTFQIPDGSYRCLALEAEESSSEDGLQGEVRLVDLEEEGTSKSRVNHGTPPLSRAPAIIQPSSCCREARGGFQHSDKPSREWDVVQARKVMTASVSSSPVPRVAQKPALGRSTSFTEKDLKEAKERSQRIAAQLTTPPSSNSRGVQLFNRRRQRVNEFTLESRGQRSPKLSQEALQTGHPSSPIGHAPGLSVNPTSPSKPGSPKHSSSQSPSRGVPGHIMEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNRETQQSSPNPPETEEVPSPAADINQNPSSPNATLTTAASNSHHNQPTADVNQNPPATITPVQQNSSETQCSPNGTLDSKPNTPSADDGQRPVPAEEVRSSILLIDKVSAPPSAASPFSREATPLSSSGPPAADLMSSSLLIGMQPSTLVASAEQEVSGHAAVTTPTKVYSEVHLTLAKPASVVNRTARPFGMQSPGTTSQIEQSPMMGRRHFGEKAWAPPASSMADRSPQPQRHIMARSPMVERRLVGQRSPVVERRPLGNFTPPPTYAETLSTAPVASQVRSPPSYSTLYPSSDPKPPHLKGQVVPANKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGMEDEPFALGAEASNFQQEPIARDRSGPAAAEETVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSGHAELARCPSPTMSLPSSWKYTTNAPGGFRVASLSPARTPPASLYHGYLPENGVLRPEPTKQQPHQMRPSLYALSPVKEPAKISSRATSSRASSRTVSPRAASPAKPSSLDLVPNLPRAGLPPSPALPRPSRSSPGLYNAPVQDSLQPTAVSPTYSSDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQVWKPSFCFK", "length": 931 }, "evidence": [ { "id": "E1BA93", "url": "https://omabrowser.org/oma/group/E1BA93/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BA93", "url": "https://www.uniprot.org/uniprotkb/E1BA93" } ], "pmid": "" }, { "name": "organelle", "id": "GO:0043226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043226", "evidence": [ { "database": "UniProtKB", "id": "E1BA93", "url": "https://www.uniprot.org/uniprotkb/E1BA93" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BA93", "url": "https://www.uniprot.org/uniprotkb/E1BA93" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BA93", "url": "https://www.uniprot.org/uniprotkb/E1BA93" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "E1BA93", "url": "https://www.uniprot.org/uniprotkb/E1BA93" } ], "pmid": "" }, { "name": "stress fiber", "id": "GO:0001725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001725", "evidence": [ { "database": "UniProtKB", "id": "E1BA93", "url": "https://www.uniprot.org/uniprotkb/E1BA93" } ], "pmid": "" }, { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "E1BA93", "url": "https://www.uniprot.org/uniprotkb/E1BA93" } ], "pmid": "" }, { "name": "spine apparatus", "id": "GO:0097444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097444", "evidence": [ { "database": "UniProtKB", "id": "E1BA93", "url": "https://www.uniprot.org/uniprotkb/E1BA93" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of actin filament bundle assembly", "id": "GO:0032233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032233", "evidence": [ { "database": "UniProtKB", "id": "E1BA93", "url": "https://www.uniprot.org/uniprotkb/E1BA93" } ], "pmid": "" }, { "name": "spine apparatus assembly", "id": "GO:1905355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905355", "evidence": [ { "database": "UniProtKB", "id": "E1BA93", "url": "https://www.uniprot.org/uniprotkb/E1BA93" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "E1BA93", "url": "https://www.uniprot.org/uniprotkb/E1BA93" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1110, "end_pos": 1112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 331, "end_pos": 333, "annotation": "n_glycosylation_sequon" }, { "start_pos": 342, "end_pos": 344, "annotation": "n_glycosylation_sequon" }, { "start_pos": 360, "end_pos": 362, "annotation": "n_glycosylation_sequon" }, { "start_pos": 480, "end_pos": 482, "annotation": "n_glycosylation_sequon" }, { "start_pos": 557, "end_pos": 559, "annotation": "n_glycosylation_sequon" }, { "start_pos": 715, "end_pos": 717, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BA93-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1128, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BA93-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BA93" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 299, 754, 928 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1110, "end_pos": 1112 }, { "start_pos": 331, "end_pos": 333 }, { "start_pos": 342, "end_pos": 344 }, { "start_pos": 360, "end_pos": 362 }, { "start_pos": 480, "end_pos": 482 }, { "start_pos": 557, "end_pos": 559 }, { "start_pos": 715, "end_pos": 717 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDC7-1", "uniprot_ac": "E1BDC7", "uniprot_id": "E1BDC7_BOVIN", "mass": { "chemical_mass": 102170.0, "monoisotopic_mass": 102170.0 }, "refseq": { "ac": "XP_005226564", "name": "synaptopodin 2-like protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226564" }, "gene_names": [ { "name": "SYNPO2L", "type": "recommended", "evidence": [ { "id": "E1BDC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDC7" } ] }, { "name": "SYNPO2L", "type": "synonym", "evidence": [ { "id": "XP_005226564", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226564" } ] } ], "protein_names": [ { "name": "Synaptopodin 2-like protein", "type": "recommended", "evidence": [ { "id": "E1BDC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDC7/entry#names_and_taxonomy" } ] }, { "name": "synaptopodin 2-like protein", "type": "synonym", "evidence": [ { "id": "XP_005226564", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226564" } ] } ], "function": [ { "annotation": "Actin-associated protein that may play a role in modulating actin-based shape.", "evidence": [ { "database": "UniProtKB", "id": "E1BDC7", "url": "https://www.uniprot.org/uniprotkb/E1BDC7#function" }, { "database": "UniProtKB", "id": "ARBA00057136", "url": "https://www.uniprot.org/uniprotkb/ARBA00057136#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDC7", "url": "https://www.uniprot.org/uniprotkb/E1BDC7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SYNPO2L", "url": "https://www.uniprot.org/uniprotkb/E1BDC7", "locus": { "chromosome": "28", "start_pos": 29626773, "end_pos": 29634765, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021132", "url": "https://www.ensembl.org/id/ENSBTAG00000021132" } ] } } ], "crossref": [ { "id": "E1BDC7", "url": "https://alphafold.ebi.ac.uk/entry/E1BDC7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021132", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021132", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10820", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10820", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "101905578", "url": "https://www.ncbi.nlm.nih.gov/gene/101905578", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051976", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051976", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101905578", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101905578", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MVQNMDG", "url": "https://omabrowser.org/oma/group/MVQNMDG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BDC7", "url": "https://www.orthodb.org/?gene=E1BDC7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24217", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24217", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24217:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24217:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005226564", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226564", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RSN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSN9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDC7", "url": "https://www.uniprot.org/uniprotkb/E1BDC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDC7-1", "url": "https://www.uniprot.org/uniprotkb/E1BDC7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAEEEVLVTLSGGAPWGFRLHGGAEQRKPLQVSKIRRRSQAGRAGLRERDQLLAINGVSCTSLSHASAMGLIDASGNQLVLTVRRVEDEGPVRSPSPGELQARSPLSPLSPEPPGAPVPQPLQPGSLLSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPAVLGPPSQGDSRVSSPSWEDGTTLQPPPAEALLLPHGPLRPGPNLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQERSVKEAKTKCRTIAALLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGLPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARPSSGTAEGRGLSEASGRGAQLFEQQRQRTASITQQPAQEVPVATLNGQGLQSPPRPQSAPPEAALLPSSPSPAPVASPRPFLPGCGTSTSAPSIFNRSARPFTPGLQGQRSGTTSVIFRPLAPKRANESLGGLSPAPPPFLSPPQGTTPVPSLTSGVPSHVPVPASPSTPRPTGPVTATSSLYIPAPNRPVTPGGAPEAPAPASGAAMTSTASIFLSSPLRPAARPEAPAPSSAAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRSGNEETKNSPNPELLSLVQNLDEKPRAGGAESGAEEDALSLGAEACNFMQPPGGRSYKTLPHVTAKTPPPMAPKTPPPTTPKTPPPVAPKPPSRGFLDGLVNGAAPSAGVPETPRLQGRGGELFAKRQSRADRYVVEAPPGPGLGPRPRSPSPTPSLPSSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPSKTQSQGPRAATKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPTSSGPPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVLSPPPPPESPRGLGTSPSSCGFQVARPRFSATRTGWQAHVWRPGAGHH", "length": 973, "header": "tr|E1BDC7-1|E1BDC7_BOVIN Isoform 1 of Synaptopodin 2-like protein OS=Bos taurus OX=9913 GN=SYNPO2L PE=3 SV=3 CANONICAL=E1BDC7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RSN9-1", "url": "https://www.uniprot.org/uniprotkb/E1BDC7/entry#A0AAA9RSN9-1", "sequence": { "sequence": "METFEPISQEPLSQASCDKAPNPVPELQDPFYAELQRAESLQERSVKEAKTKCRTIAALLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGLPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARPSSGTAEGRGLSEASGRGAQLFEQQRQRTASITQQPAQEVPVATLNGQGLQSPPRPQSAPPEAALLPSSPSPAPVASPRPFLPGCGTSTSAPSIFNRSARPFTPGLQGQRSGTTSVIFRPLAPKRANESLGGLSPAPPPFLSPPQGTTPVPSLTSGVPSHVPVPASPSTPRPTGPVTATSSLYIPAPNRPVTPGGAPEAPAPASGAAMTSTASIFLSSPLRPAARPEAPAPSSAAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRSGNEETKNSPNPELLSLVQNLDEKPRAGGAESGAEEDALSLGAEACNFMQPPGGRSYKTLPHVTAKTPPPMAPKTPPPTTPKTPPPVAPKPPSRGFLDGLVNGAAPSAGVPETPRLQGRGGELFAKRQSRADRYVVEAPPGPGLGPRPRSPSPTPSLPSSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPSKTQSQGPRAATKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPTSSGPPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVLSPPPPPESPRGLGTSPSSCGFQVARPRFSATRTGWQAHVWRPGAGHH", "length": 749, "header": "tr|A0AAA9RSN9-1|E1BDC7_BOVIN Computationally mapped isoform of Synaptopodin 2-like protein OS=Bos taurus OX=9913 GN=SYNPO2L PE=3 SV=1 CANONICAL=E1BDC7-1" }, "locus": { "chromosome": "28", "start_pos": 29630941, "end_pos": 29626776, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100489.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100489.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075680.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075680.1" } ] } }, { "isoform_ac": "E1BDC7-1", "url": "https://www.uniprot.org/uniprotkb/E1BDC7/entry#E1BDC7-1", "sequence": { "sequence": "MGAEEEVLVTLSGGAPWGFRLHGGAEQRKPLQVSKIRRRSQAGRAGLRERDQLLAINGVSCTSLSHASAMGLIDASGNQLVLTVRRVEDEGPVRSPSPGELQARSPLSPLSPEPPGAPVPQPLQPGSLLSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPAVLGPPSQGDSRVSSPSWEDGTTLQPPPAEALLLPHGPLRPGPNLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQERSVKEAKTKCRTIAALLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGLPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARPSSGTAEGRGLSEASGRGAQLFEQQRQRTASITQQPAQEVPVATLNGQGLQSPPRPQSAPPEAALLPSSPSPAPVASPRPFLPGCGTSTSAPSIFNRSARPFTPGLQGQRSGTTSVIFRPLAPKRANESLGGLSPAPPPFLSPPQGTTPVPSLTSGVPSHVPVPASPSTPRPTGPVTATSSLYIPAPNRPVTPGGAPEAPAPASGAAMTSTASIFLSSPLRPAARPEAPAPSSAAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRSGNEETKNSPNPELLSLVQNLDEKPRAGGAESGAEEDALSLGAEACNFMQPPGGRSYKTLPHVTAKTPPPMAPKTPPPTTPKTPPPVAPKPPSRGFLDGLVNGAAPSAGVPETPRLQGRGGELFAKRQSRADRYVVEAPPGPGLGPRPRSPSPTPSLPSSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPSKTQSQGPRAATKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPTSSGPPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVLSPPPPPESPRGLGTSPSSCGFQVARPRFSATRTGWQAHVWRPGAGHH", "length": 973, "header": "tr|E1BDC7-1|E1BDC7_BOVIN Isoform 1 of Synaptopodin 2-like protein OS=Bos taurus OX=9913 GN=SYNPO2L PE=3 SV=3 CANONICAL=E1BDC7-1" }, "locus": { "chromosome": "28", "start_pos": 29634566, "end_pos": 29626776, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026992.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026992.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026992.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026992.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 166, "start_aa": "Thr", "end_pos": 166, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr166", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 555, "start_aa": "Thr", "end_pos": 555, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr555", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 787, "start_aa": "Thr", "end_pos": 787, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr787", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 866, "start_aa": "Thr", "end_pos": 866, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr866", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 870, "start_aa": "Thr", "end_pos": 870, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr870", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:101905578", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101905578", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SU55-1", "protein_name": "Synaptopodin 2 like", "gene_name": "SYNPO2L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLIDASGNQLVLTVRRREDEGPVRSPSPGELQALSPLSPLSPEPPGAPVPQPLQPGSLLSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTAPGAPPDEIYLSDSPAEPAPAVLGSPSQGDSRLSSPSWEDGSTLQPPPAEALLLPRGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQERSVKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARPGSGAAEGQGPGQGGQLIEASGRGAQLFEQQRQRAASSTQELAPEGPATMLNGQGLQTPPRAQSAPPEAAVPASSPSPAPEAIPRPFLPGGGVSTPAPSIFNRSARPFTPGLQGHRPGTTSVIFRPLAPKRANESLGGLSPAPPPFLSSPQGTTPLPSFTSGVPSHVSAPGSPGTPRSLGPLTATSSLYIPAPSRPVTPGGAPEPPAPSSGAAMTSTASIFLSAPPRSAPRPEAPAPGPAAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGNEETKNSPNPELLSLVQNLDEKPRPGGGESGPEEDALSLGAEACNFMQPPGGRSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPTRGLLDGLVNGASPSAGVPEPPRLQGRGGELFAKRQSRADRYVVEATPGPGLGPRPRSPSPTPSLPSSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRAAPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPTALGPPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRAELASAPVLSPAPPPESPRGLGTSPSSCGFQVARPRFSATRTGLQAHVWRPGAGHH", "length": 909 }, "evidence": [ { "id": "E1BDC7", "url": "https://omabrowser.org/oma/group/E1BDC7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9H987-1", "protein_name": "Synaptopodin 2-like protein", "gene_name": "SYNPO2L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGAEEEVLVTLSGGAPWGFRLHGGAEQRKPLQVSKIRRRSQAGRAGLRERDQLLAINGVSCTNLSHASAMSLIDASGNQLVLTVQRLADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDADGPATQEKPRRPRRRGPTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVSSPSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDARSLTNQSDWDSPYLDMELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPMTPKTPPPVAPKPPSRGLLDGLVNGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPTPSLPPSWKYSPNIRAPPPIAYNPLLSPFFPQAARTLPKAQSQGPRATPKQGIKALDFMRHQPYQLKTAMFCFDEVPPTPGPIASGSPKTARVQEIRRFSTPAPQPTAEPLAPTVLAPRAATTLDEPIWRTELASAPVPSPAPPPEAPRGLGASPSSCGFQVARPRFSATRTGLQAHVWRPGAGHQ", "length": 977 }, "evidence": [ { "id": "E1BDC7", "url": "https://omabrowser.org/oma/group/E1BDC7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BDC7", "url": "https://www.uniprot.org/uniprotkb/E1BDC7" } ], "pmid": "" }, { "name": "organelle", "id": "GO:0043226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043226", "evidence": [ { "database": "UniProtKB", "id": "E1BDC7", "url": "https://www.uniprot.org/uniprotkb/E1BDC7" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BDC7", "url": "https://www.uniprot.org/uniprotkb/E1BDC7" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "E1BDC7", "url": "https://www.uniprot.org/uniprotkb/E1BDC7" } ], "pmid": "" }, { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "E1BDC7", "url": "https://www.uniprot.org/uniprotkb/E1BDC7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of actin filament bundle assembly", "id": "GO:0032233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032233", "evidence": [ { "database": "UniProtKB", "id": "E1BDC7", "url": "https://www.uniprot.org/uniprotkb/E1BDC7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "E1BDC7", "url": "https://www.uniprot.org/uniprotkb/E1BDC7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 348, "end_pos": 350, "annotation": "n_glycosylation_sequon" }, { "start_pos": 459, "end_pos": 461, "annotation": "n_glycosylation_sequon" }, { "start_pos": 490, "end_pos": 492, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDC7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 973, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDC7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDC7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDC7" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 6, "end_pos": 88, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 166, 555, 787, 866, 870 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 348, "end_pos": 350 }, { "start_pos": 459, "end_pos": 461 }, { "start_pos": 490, "end_pos": 492 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_o_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_o_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B7S3-1", "uniprot_ac": "E1B7S3", "uniprot_id": "E1B7S3_BOVIN", "mass": { "chemical_mass": 121179.0, "monoisotopic_mass": 121179.0 }, "refseq": { "ac": "NP_001193098", "name": "band 4.1-like protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193098" }, "gene_names": [ { "name": "EPB41L3", "type": "recommended", "evidence": [ { "id": "E1B7S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S3" } ] }, { "name": "EPB41L3", "type": "synonym", "evidence": [ { "id": "NP_001193098", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193098" } ] } ], "protein_names": [ { "name": "Protein 4.1", "type": "recommended", "evidence": [ { "id": "E1B7S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S3/entry#names_and_taxonomy" } ] }, { "name": "4.1R", "type": "synonym", "evidence": [ { "id": "E1B7S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S3/entry#names_and_taxonomy" } ] }, { "name": "Band 4.1", "type": "synonym", "evidence": [ { "id": "E1B7S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S3/entry#names_and_taxonomy" } ] }, { "name": "Erythrocyte membrane protein band 4.1", "type": "synonym", "evidence": [ { "id": "E1B7S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S3/entry#names_and_taxonomy" } ] }, { "name": "band 4.1-like protein 3", "type": "synonym", "evidence": [ { "id": "NP_001193098", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193098" } ] } ], "function": [ { "annotation": "Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.", "evidence": [ { "database": "UniProtKB", "id": "E1B7S3", "url": "https://www.uniprot.org/uniprotkb/E1B7S3#function" }, { "database": "UniProtKB", "id": "ARBA00054563", "url": "https://www.uniprot.org/uniprotkb/ARBA00054563#function" }, { "database": "UniProtKB", "id": "A0AAA9RU53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RU53#function" }, { "database": "UniProtKB", "id": "A0AAA9SIM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIM5#function" }, { "database": "UniProtKB", "id": "A0AAA9T5S5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5S5#function" }, { "database": "UniProtKB", "id": "A0AAA9THS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7S3", "url": "https://www.uniprot.org/uniprotkb/E1B7S3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EPB41L3", "url": "https://www.uniprot.org/uniprotkb/E1B7S3", "locus": { "chromosome": "24", "start_pos": 38880422, "end_pos": 39061023, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019251", "url": "https://www.ensembl.org/id/ENSBTAG00000019251" } ] } } ], "crossref": [ { "id": "E1B7S3", "url": "https://alphafold.ebi.ac.uk/entry/E1B7S3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019251", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019251", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13184", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13184", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14473", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14473", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17203", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17203", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532616", "url": "https://www.ncbi.nlm.nih.gov/gene/532616", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000798", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000798", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007477", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007477", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008379", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008379", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014847", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014847", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019747", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019747", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019748", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019748", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019749", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019749", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030691", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035963", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035963", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532616", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532616", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SSEEEXA", "url": "https://omabrowser.org/oma/group/SSEEEXA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7S3", "url": "https://www.orthodb.org/?gene=E1B7S3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23280", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23280", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23280:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23280:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04382", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04382", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05902", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05902", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08736", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08736", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09379", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09379", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09380", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09380", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6794361", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6794361", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193098", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RU53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RU53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RU53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RU53-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIM5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5S5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5S5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5S5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5S5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7S3", "url": "https://www.uniprot.org/uniprotkb/E1B7S3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7S3-1", "url": "https://www.uniprot.org/uniprotkb/E1B7S3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTESGSDSESKPEQEAEPQEAAGREGAQPGAQPGPEPAAEEQPQAPEQFEEAAAHSTPVRKEVTDKDQEFAAGPAKQLEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQIRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVDIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEVGTGQYITTKGMSQTNLITTVTPEKKAEEERDEEEDRRKKAEEATPVAAVRHEGKSPGLGTDSCPPLPPSAHRPPASPTGLRRRCKENGQPPLGVELARDSRRQHGEPASDPDSRGKPCPGDHDVALGYKPQPGRGATLFSFSLQLPGSFPSLLDDDGYLSFPNLSESALLPQSLQHYLPIRSPSLVPCFLFIFFFLLSASFSVPYALTLSFPLALCLCYLEPKAASLSASLDNDPSDSSEEETDSERTDTAADGETTATESDQEEDAELKAQELDKTQDDLMKHQTNISELKRTFLETSTDTAITNEWEKRLSTSPVRLAARQEDAPMIEPLVPEETKQTSGEKLMDGSEILSLLESARKPTEFIGAVTSTSQSWVQKTETKMESSDIETETAQQPQPPSVEKVVQETVLVEERHVMNVHASGDACYVAGDDADTATQAAPADASGAKEKEGSALTEGAKEEKGEVADKVVVEQDEMATASCEPEEEQTAAVHVSETLEQKPHFESSTVKTETISFGSVSPGEVKLEISTKEVPVVHTETKTITYESSQVDLGADLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEISPEDGED", "length": 1095, "header": "tr|E1B7S3-1|E1B7S3_BOVIN Isoform 1 of Protein 4.1 OS=Bos taurus OX=9913 GN=EPB41L3 PE=4 SV=3 CANONICAL=E1B7S3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RU53-1", "url": "https://www.uniprot.org/uniprotkb/E1B7S3/entry#A0AAA9RU53-1", "sequence": { "sequence": "MTTESGSDSESKPEQEAEPQEAAGREGAQPGAQPGPEPAAEEQPQAPEQFEEAAAHSTPVRKEVTDKDQEFAAGPAKQLEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQIRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVDIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGASVNENHEIYMKDSVSAAEVGTGQYITTKGMSQTNLITTVTPEKKAEEERDEEEDRRKKAEEATPVAAVRHEGKTDSERTDTAADGETTATETKQTSGEKLMDGSEILSLLESARKPTEFIGAVTSTSQSWVQKTETKMESSDIETETAQQPQPPSVEKVVQETVLVEERHVMNVHASGDACYVAGDDADTATQAAPADASGAKEKEGSALTEGAKEEKGEVADKVVVEQDEMATASCEPEEEQTAAVHVSETLEQKPHFESSTVKTETISFGSVSPGEVKLEISTKEVPVVHTETKTITYESSQVDLGADLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEISPEDGED", "length": 849, "header": "tr|A0AAA9RU53-1|E1B7S3_BOVIN Computationally mapped isoform of Protein 4.1 OS=Bos taurus OX=9913 GN=EPB41L3 PE=4 SV=1 CANONICAL=E1B7S3-1" }, "locus": { "chromosome": "24", "start_pos": 38973547, "end_pos": 38882742, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103956.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103956.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076663.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076663.1" } ] } }, { "isoform_ac": "A0AAA9SIM5-1", "url": "https://www.uniprot.org/uniprotkb/E1B7S3/entry#A0AAA9SIM5-1", "sequence": { "sequence": "MTTESGSDSESKPEQEAEPQEAAGREGAQPGAQPGPEPAAEEQPQAPEQFEEAAAHSTPVRKEVTDKDQEFAAGPAKQLEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQIRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVDIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGASVNENHEIYMKDSVSAAEVGTGQYITTKGMSQTNLITTVTPEKKAEEERDEEEDRRKKAEEATPVAAVRHEGKTDSERTDTAADGETTATENSLIKRIKGENVYVKHSNLMLEELDKTQDDLMKHQTNISELKRTFLETSTDTAITNEWEKRLSTSPVRLAARQEDAPMIEPLVPEEKTETKMESSDIETETAQQPQPPSVEKVVQETVLVEERHVMNVHASGDACYVAGDDADTATQAAPADASGAKEKEGSALTEGAKEEKGEVADKVVVEQDEMATASCEPEEEQTAAVHVSETLEQKPHFESSTVKTETISFGSVSPGEVKLEISTKEVPVVHTETKTITYESSQVDLGADLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEISPEDGED", "length": 894, "header": "tr|A0AAA9SIM5-1|E1B7S3_BOVIN Computationally mapped isoform of Protein 4.1 OS=Bos taurus OX=9913 GN=EPB41L3 PE=4 SV=1 CANONICAL=E1B7S3-1" }, "locus": { "chromosome": "24", "start_pos": 38973547, "end_pos": 38882742, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124990.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124990.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086100.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086100.1" } ] } }, { "isoform_ac": "A0AAA9T5S5-1", "url": "https://www.uniprot.org/uniprotkb/E1B7S3/entry#A0AAA9T5S5-1", "sequence": { "sequence": "MTTESGSDSESKPEQEAEPQEAAGREGAQPGAQPGPEPAAEEQPQAPEQFEEAAAHSTPVRKEVTDKDQEFAAGPAKQLEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQIRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVDIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGASVNENHEIYMKDSVSAAEVGTGQYITTKGMSQTNLITTVTPEKKAEEERDEEEDRRKKAEEATPVAAVRHEGKTDSERTDTAADGETTATEELDKTQDDLMKHQTNISELKRTFLETSTDTAITNEWEKRLSTSPVRLAARQEDAPMIEPLVPEETKQTSGEKLMDGSEILSLLESARKPTEFIGAVTSTSQSWVQKTETKMESSDIETETAQQPQPPSVEKVVQETVLVEERHVMNVHASGDACYVAGDDADTATQAAPADASGAKEKEGSALTEGAKEEKGEVADKVVVEQDEMATASCEPEEEQTAAVHVSETLEQKPHFESSTVKTETISFGSVSPGEVKLEISTKEVPVVHTETKTITYESSQVDLGADLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEISPEDGED", "length": 913, "header": "tr|A0AAA9T5S5-1|E1B7S3_BOVIN Computationally mapped isoform of Protein 4.1 OS=Bos taurus OX=9913 GN=EPB41L3 PE=4 SV=1 CANONICAL=E1B7S3-1" }, "locus": { "chromosome": "24", "start_pos": 38973547, "end_pos": 38882742, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090794.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090794.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094119.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094119.1" } ] } }, { "isoform_ac": "A0AAA9THS7-1", "url": "https://www.uniprot.org/uniprotkb/E1B7S3/entry#A0AAA9THS7-1", "sequence": { "sequence": "MPSFICLYLCSKSLLGFGEQSTMTTESGSDSESKPEQEAEPQEAAGREGAQPGAQPGPEPAAEEQPQAPEQFEEAAAHSTPVRKEVTDKDQEFAAGPAKQLEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQIRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVDIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGASVNENHEIYMKDSVSAAEVGTGQYITTKGMSQTNLITTVTPEKKAEEERDEEEDRRKKAEEATPVAAVRHEGKTDSERTDTAADGETTATESDQEEDAELKAQELDKTQDDLMKHQTNISELKRTFLETSTDTAITNEWEKRLSTSPVRLAARQEDAPMIEPLVPEETKQTSGEKLMDGSEILSLLESARKPTEFIGAVTSTSQSWVQKTETKMESSDIETETAQQPQPPSVEKVVQETVLVEERHVMNVHASGDACYVAGDDADTATQAAPADASGAKEKEGSALTEGAKEEKGEVADKVVVEQDEMATASCEPEEEQTAAVHVSETLEQKPHFESSTVKTETISFGSVSPGEVKLEISTKEVPVVHTETKTITYESSQVDLGADLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEISPEDGED", "length": 947, "header": "tr|A0AAA9THS7-1|E1B7S3_BOVIN Computationally mapped isoform of Protein 4.1 OS=Bos taurus OX=9913 GN=EPB41L3 PE=4 SV=1 CANONICAL=E1B7S3-1" }, "locus": { "chromosome": "24", "start_pos": 39060918, "end_pos": 38882742, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119209.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119209.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098073.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098073.1" } ] } }, { "isoform_ac": "E1B7S3-1", "url": "https://www.uniprot.org/uniprotkb/E1B7S3/entry#E1B7S3-1", "sequence": { "sequence": "MTTESGSDSESKPEQEAEPQEAAGREGAQPGAQPGPEPAAEEQPQAPEQFEEAAAHSTPVRKEVTDKDQEFAAGPAKQLEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQIRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVDIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEVGTGQYITTKGMSQTNLITTVTPEKKAEEERDEEEDRRKKAEEATPVAAVRHEGKSPGLGTDSCPPLPPSAHRPPASPTGLRRRCKENGQPPLGVELARDSRRQHGEPASDPDSRGKPCPGDHDVALGYKPQPGRGATLFSFSLQLPGSFPSLLDDDGYLSFPNLSESALLPQSLQHYLPIRSPSLVPCFLFIFFFLLSASFSVPYALTLSFPLALCLCYLEPKAASLSASLDNDPSDSSEEETDSERTDTAADGETTATESDQEEDAELKAQELDKTQDDLMKHQTNISELKRTFLETSTDTAITNEWEKRLSTSPVRLAARQEDAPMIEPLVPEETKQTSGEKLMDGSEILSLLESARKPTEFIGAVTSTSQSWVQKTETKMESSDIETETAQQPQPPSVEKVVQETVLVEERHVMNVHASGDACYVAGDDADTATQAAPADASGAKEKEGSALTEGAKEEKGEVADKVVVEQDEMATASCEPEEEQTAAVHVSETLEQKPHFESSTVKTETISFGSVSPGEVKLEISTKEVPVVHTETKTITYESSQVDLGADLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEISPEDGED", "length": 1095, "header": "tr|E1B7S3-1|E1B7S3_BOVIN Isoform 1 of Protein 4.1 OS=Bos taurus OX=9913 GN=EPB41L3 PE=4 SV=3 CANONICAL=E1B7S3-1" }, "locus": { "chromosome": "24", "start_pos": 38973547, "end_pos": 38882742, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061281.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061281.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053167.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053167.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:532616", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532616", "resource": "KEGG Pathway" }, { "id": "R-BTA-6794361", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6794361", "resource": "Reactome", "description": "Neurexins and neuroligins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7GR42-1", "protein_name": "Band 4.1-like protein 3 isoform X1", "gene_name": "Epb41l3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTTESGSDSESKPDQEAEPQEAAGPQGQPGAQPGPEPASGSSEDPPALEQFPAAAAHSTPVKREVSDKDRDFAAAAAKQLEYQQFEDDKLSQKSSSSKLSRSPLKIVKRPKSMQCKVTLLDGSDYGCDVDKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQIRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEEKVVELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGASVNETHEMYMKDSMSAAEVGTGQYATTKGISQTNLITSVTPEKKAEEEHGEEEDRRRKAEEATPVTALRHEGKSPGHGAADSCPLSPPSAHLDPASPTELRRRCKENESPLAASVLPNAEPASASDGQGKACLGDQDVAFSYRQQTGKGTTLFSFSLQLPESFPSLLDEDGYLSFPNLSETNLLPQSWQQFLPIRSPSLLPCFLFIFFFLLSASFSVPYALTLSFPLALCLCYLEPKAASLSASLDNDPSDSSEEETDSERTDTAADGETSATESDQEEDAELKAQELDKTQDELMKHQTNISELKRTFLETSTETALTNEWEKRLSTSPVRLAARQEEAPMIEPLVPEETKQSSGEKLMDGSEILSLLESARKPTEFIGGVSSTTQSWVQKLETKTESIETEVELTPHSQPLSTEKVLQETVLAEERRIESVQGSGDACHTAGDAVDTAETTPSDLHSAKGKEGCSVTEAAKEERGEEADKSVPEQEQPATVSHEEEQVAATHPSEALEQKSHFESSTVKMETVSVGSVSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGADLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEITPEDGED", "length": 1106 }, "evidence": [ { "id": "E1B7S3", "url": "https://omabrowser.org/oma/group/E1B7S3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9WV92-1", "protein_name": "Band 4.1-like protein 3", "gene_name": "Epb41l3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTTESGSDSESKPDQEAEPQEAAGPQGQAGAQPGPEPAGGNGSLNGEKQQPALEQFPEAAAHSTPVKREIGDKDRDFAAAAAKQLEYQQFEDDKLSQRSSSSKLSRSPLKIVKRPKSMQCKVTLLDGSEYGCDVDKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQIRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGNDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGASVSENHEIYMKDSVSAAEVGTGQYATTKGISQTNLITTVTPEKKAEEERVEEEDRRKKAEEATPVTALRHEGKTDSERTDTAADGETSATESDQEEDAEIKAQDLDKTQDELMKHQTNISELKRTFLETSTETALTNEWEKRLSTSPVRLAARQEDAPMIEPLVPEETKQSSGEKLMDGSEILSLLESARKPTEFIGGVSSTTQSWVQKLETKTEPVEAEVESTPHPQPLSTEKVLQETILVEERHVMSVHASGDASHTARDEVDAAESTPTDRRHTGKGKEGSSVTEAAKEQRGEEVDQSAPEQEQPATVSHEEEQASTIRTSEGLEQKSHFESSTVRVESTSVGSISPGGAKLEISTKEVPVVHTETKTITYESSQVDPGADLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEITPEDGED", "length": 929 }, "evidence": [ { "id": "E1B7S3", "url": "https://omabrowser.org/oma/group/E1B7S3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y2J2-1", "protein_name": "Band 4.1-like protein 3", "gene_name": "EPB41L3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTTESGSDSESKPDQEAEPQEAAGAQGRAGAPVPEPPKEEQQQALEQFAAAAAHSTPVRREVTDKEQEFAARAAKQLEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEVGTGQYATTKGISQTNLITTVTPEKKAEEERDEEEDKRRKGEEVTPISAIRHEGKSPGLGTDSCPLSPPSTHCAPTSPTELRRRCKENDCKLPGYEPSRAEHLPGEPALDSDGPGRPYLGDQDVAFSYRQQTGKGTTLFSFSLQLPESFPSLLDDDGYLSFPNLSETNLLPQSLQHYLPIRSPSLVPCFLFIFFFLLSASFSVPYALTLSFPLALCLCYLEPKAASLSASLDNDPSDSSEEETDSERTDTAADGETTATESDQEEDAELKAQELEKTQDDLMKHQTNISELKRTFLETSTDTAVTNEWEKRLSTSPVRLAARQEDAPMIEPLVPEETKQSSGEKLMDGSEIFSLLESARKPTEFIGGVTSTSQSWVQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEGAKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEITPEDGED", "length": 1087 }, "evidence": [ { "id": "E1B7S3", "url": "https://omabrowser.org/oma/group/E1B7S3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "E1B7S3", "url": "https://www.uniprot.org/uniprotkb/E1B7S3" } ], "pmid": "" }, { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "E1B7S3", "url": "https://www.uniprot.org/uniprotkb/E1B7S3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "E1B7S3", "url": "https://www.uniprot.org/uniprotkb/E1B7S3" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "E1B7S3", "url": "https://www.uniprot.org/uniprotkb/E1B7S3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B7S3", "url": "https://www.uniprot.org/uniprotkb/E1B7S3" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "E1B7S3", "url": "https://www.uniprot.org/uniprotkb/E1B7S3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cortical actin cytoskeleton organization", "id": "GO:0030866", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030866", "evidence": [ { "database": "UniProtKB", "id": "E1B7S3", "url": "https://www.uniprot.org/uniprotkb/E1B7S3" } ], "pmid": "" }, { "name": "actomyosin structure organization", "id": "GO:0031032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031032", "evidence": [ { "database": "UniProtKB", "id": "E1B7S3", "url": "https://www.uniprot.org/uniprotkb/E1B7S3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 260, "end_pos": 262, "annotation": "n_glycosylation_sequon" }, { "start_pos": 613, "end_pos": 615, "annotation": "n_glycosylation_sequon" }, { "start_pos": 737, "end_pos": 739, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7S3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1095, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7S3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7S3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S3" }, { "id": "PS50057", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50057" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FERM", "eco_id": "ECO_0000259", "start_pos": 112, "end_pos": 393, "start_aa": "Met", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 260, "end_pos": 262 }, { "start_pos": 613, "end_pos": 615 }, { "start_pos": 737, "end_pos": 739 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCD5-1", "uniprot_ac": "E1BCD5", "uniprot_id": "E1BCD5_BOVIN", "mass": { "chemical_mass": 222716.0, "monoisotopic_mass": 222716.0 }, "refseq": { "ac": "XP_024842994", "name": "pecanex-like protein 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842994" }, "gene_names": [ { "name": "PCNX3", "type": "recommended", "evidence": [ { "id": "E1BCD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCD5" } ] }, { "name": "PCNX3", "type": "synonym", "evidence": [ { "id": "XP_024842994", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842994" } ] }, { "name": "PCNXL3", "type": "synonym", "evidence": [ { "id": "XP_024842994", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842994" } ] } ], "protein_names": [ { "name": "Pecanex-like protein", "type": "recommended", "evidence": [ { "id": "E1BCD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCD5/entry#names_and_taxonomy" } ] }, { "name": "pecanex-like protein 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024842994", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842994" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCD5", "url": "https://www.uniprot.org/uniprotkb/E1BCD5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCNX3", "url": "https://www.uniprot.org/uniprotkb/E1BCD5", "locus": { "chromosome": "29", "start_pos": 43815656, "end_pos": 43796611, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003759", "url": "https://www.ensembl.org/id/ENSBTAG00000003759" } ] } } ], "crossref": [ { "id": "ENSBTAG00000003759", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003759", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "536942", "url": "https://www.ncbi.nlm.nih.gov/gene/536942", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007735", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007735", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QSWPHHP", "url": "https://omabrowser.org/oma/group/QSWPHHP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCD5", "url": "https://www.orthodb.org/?gene=E1BCD5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12372", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12372", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12372:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12372:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024842994", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842994", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RUK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIV4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCD5", "url": "https://www.uniprot.org/uniprotkb/E1BCD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCD5-1", "url": "https://www.uniprot.org/uniprotkb/E1BCD5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSQVLQILRQGVWASLTGGWFFDPHQSTFSNCFHLYVWIFLLTFPFLLYMVLPPSLMVAGVYCLVVAVIFATIKTVNYRLHAMFDQGEIVEKRNSTMGEPEEEPAQGDNNLPRDPGVEMTVFRKVSSTPPVRCSSQHSVFGFNQVSELLPRIEDSGPLRDIKELVREQGSNNVIVTSADREMLKLSSQEKLIGDLPQTPPGAAPDPSLPSTDSSERSPLAGDGAPWSGGSVADTPMSPLLKGSLSQELSKSFLTLTRPERALVRTSSRREQRRGAGGYQPLDRRGSGDPTPQKAGSSDSCFSGTDRETLSSFKSEKTNSTHLDSPPGGQAPEGSDTDPPSEAELPASPDAGVPSDDTLRSFDTVVGAGTPPGPAEPLLVVRPKDLALLRPSKRRPPVRRHSPATGRAPRRPLLEGRGFFEDDDTSEGSELSPASSLRSQRRYSTDSSSSTSCYSPASSRGAAGGARKRRAPHGAEEGMAVPPKRPYGTQRTPSTASAKTHARVLSMDGAGGDALRGPPAGSKAELEAQAGVELAAAEPTVLAAEARRGPAANQPGWRGELREEGALGGAAEETGKRDHSSNVRRAQAIRRRHNAGSNPTPPASVMGSPPSSLQEAQRGRAASHSRALTLPSALHFASSLLLTRAGANVHEACTFDDTSEGAVHYFYDESGVRRSYTFGLAGGGYENPVGQQGEQAANGAWDRHSHSSSFHSADVPEATGGLNLLQPRPVVLQGMQVRRVPLEIPEFDLLDQDSLHESQEQTLMEEAPPRAQHSYKYWLLPGRWTSVRYERLALLALLDRTRGLLENILGVGLSSLVAFLGYLLLLKGFFTDIWVFQFCLVIASCQYSLLKSVQPDAASPMHGHNWVIAYSRPVYFCICCLLIWLLDALGSAQPFPPVSLYGLTLFSASFFFCARDVATVFTLCFPFVFLLGLLPQVNTCLMYLLEQIDMHGFGGTAATSPLTAVFSLSRSLLAAALLYGFCLGAIKSPWPEQHVPVIFSVFCGLLVALSYHLSRQSSDPTVLWSLVRSKLFPELEERSLETARAEPPDPLPEKMRQSVREVLHSDLVMCVVIAVLTFAISASTVFIALKSVLGFVLYALAGAVGFFTHYLLPQLRKQLPWFCLSQPVLKPLEYSQYEVRGAAQVMWFEKLYAGLQCVEKYLIYPAVVLNALTVDAHTVVSHPDKFCLYCRALLMTVAGLKLLRSAFCCPPQQYLTLAFTVLLFHFDYPRLSQGFLLDYFLMSLLCSKLWDLLYKLRFVLTYIAPWQITWGSAFHAFAQPFAVPHSAMLFVQALLSALFSTPLNPLLGSAVFIMSYARPLKFWERDYNTKRVDHSNTRLVTQLDRNPGADDNNLNSIFYEHLTRSLQHTLCGDLVLGRWGNYGPGDCFVLASDYLNALVHLIEVGNGLVTFQLRGLEFRGTYCQQREVEAITEGVEEDEGCCCCEPGHLPRVLSFNAAFGQRWLAWEVTASKYVLEGYSISDNNAASMLQVFDLRKILVTYYVRSIIYYVSRSPKLEAWLSHEGIATALRPVRAPGYADSDPTFSLSVDEDYDLRLSGLSLPSFCAVHLEWIQYCASRRSQPVDQDWNSPLVTLCFGLCVLGRRALGTASHSMSASLEPFLYGLHALFKGDFRITSPRDEWVFADMDLLHRVVAPGVRMALKLHQDHFTSPDEYEEPAALYDAIAANEERLVISHEGDPAWRSAILSNTPSLLALRHVLDDASDEYKIIMLNRRHLSFRVIKVNRECVRGLWAGQQQELVFLRNRNPERGSIQNAKQALRNMINSSCDQPLGYPIYVSPLTTSLAGSHPQLRALWGGPVSLGAIARWLLRSWERLHKGCGAGCNSGGNVDDSDCGGGGGLTSLSNNPPLAQPTPENTAGAGDQPPPPGPAWGPRPSLSGSGDGRPPPLLQWPPPRLPGPSPASPALPEGPRPSRPPGPGLLSSEGPSGKWSLGGRKGLGGSDGEPASGSPKGSTPKSQAPLDLSLSPDISTEASPPRTVQDIPCLDSSAPETGTPTGALGDWPAPAEERESPAAQPLLEHQY", "length": 2042, "header": "tr|E1BCD5-1|E1BCD5_BOVIN Isoform 1 of Pecanex-like protein OS=Bos taurus OX=9913 GN=PCNX3 PE=3 SV=3 CANONICAL=E1BCD5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RUK5-1", "url": "https://www.uniprot.org/uniprotkb/E1BCD5/entry#A0AAA9RUK5-1", "sequence": { "sequence": "MGSQVLQILRQGVWASLTGGWFFDPHQSTFSNCFHLYVWIFLLTFPFLLYMVLPPSLMVAGVYCLVVAVIFATIKTVNYRLHAMFDQGEIVEKRNSTMGEPEEEPAQGDNNLPRDPGVEMTVFRKVSSTPPVRCSSQHSVFGFNQVSELLPRIEDSGPLRDIKELVREQGSNNVIVTSADREMLKLSSQEKLIGDLPQTPPGAAPDPSLPSTDSSERSPLAGDGAPWSGGSVADTPMSPLLKGSLSQELSKSFLTLTRPERALVRTSSRREQRRGAGGYQPLDRRGSGDPTPQKAGSSDSCFSGTDRETLSSFKSEKTNSTHLDSPPGGQAPEGSDTDPPSEAELPASPDAGVPSDDTLRSFDTVVGAGTPPGPAEPLLVVRPKDLALLRPSKRRPPVRRHSPATGRAPRRPLLEGRGFFEDDDTSEGSELSPASSLRSQRRYSTDSSSSTSCYSPASSRGAAGGARKRRAPHGAEEGMAVPPKRPYGTQRTPSTASAKTHARVLSMDGAGGDALRGPPAGSKAELEAQAGVELAAAEPTVLAAEARRGPAANQPGWRGELREEGALGGAAEETGKRDHSSNVRRAQAIRRRHNAGSNPTPPASVMGSPPSLQEAQRGRAASHSRALTLPSALHFASSLLLTRAGANVHEACTFDDTSEGAVHYFYDESGVRRSYTFGLAGGGYENPVGQQGEQAANGAWDRHSHSSSFHSADVPEATGGLNLLQPRPVVLQGMQVRRVPLEIPEFDLLDQDSLHESQEQTLMEEAPPRAQHSYKYWLLPGRWTSVRYERLALLALLDRTRGLLENILGVGLSSLVAFLGYLLLLKGFFTDIWVFQFCLVIASCQYSLLKSVQPDAASPMHGHNWVIAYSRPVYFCICCLLIWLLDALGSAQPFPPVSLYGLTLFSASFFFCARDVATVFTLCFPFVFLLGLLPQVNTCLMYLLEQIDMHGFGGTAATSPLTAVFSLSRSLLAAALLYGFCLGAIKSPWPEQHVPVIFSVFCGLLVALSYHLSRQSSDPTVLWSLVRSKLFPELEERSLETARAEPPDPLPEKMRQSVREVLHSDLVMCVVIAVLTFAISASTVFIALKSVLGFVLYALAGAVGFFTHYLLPQLRKQLPWFCLSQPVLKPLEYSQYEVRGAAQVMWFEKLYAGLQCVEKYLIYPAVVLNALTVDAHTVVSHPDKFCLYCRALLMTVAGLKLLRSAFCCPPQQYLTLAFTVLLFHFDYPRLSQGFLLDYFLMSLLCSKLWDLLYKLRFVLTYIAPWQITWGSAFHAFAQPFAVPHSAMLFVQALLSALFSTPLNPLLGSAVFIMSYARPLKFWERDYNTKRVDHSNTRLVTQLDRNPGADDNNLNSIFYEHLTRSLQHTLCGDLVLGRWGNYGPGDCFVLASDYLNALVHLIEVGNGLVTFQLRGLEFRGTYCQQREVEAITEGVEEDEGCCCCEPGHLPRVLSFNAAFGQRWLAWEVTASKYVLEGYSISDNNAASMLQVFDLRKILVTYYVRSIIYYVSRSPKLEAWLSHEGIATALRPVRAPGYADSDPTFSLSVDEDYDLRLSGLSLPSFCAVHLEWIQYCASRRSQPVDQDWNSPLVTLCFGLCVLGRRALGTASHSMSASLEPFLYGLHALFKGDFRITSPRDEWVFADMDLLHRVVAPGVRMALKLHQDHFTSPDEYEEPAALYDAIAANEERLVISHEGDPAWRSAILSNTPSLLALRHVLDDASDEYKIIMLNRRHLSFRVIKVNRECVRGLWAGQQQELVFLRNRNPERGSIQNAKQALRNMINSSCDQPLGYPIYVSPLTTSLAGSHPQLRALWGGPVSLGAIARWLLRSWERLHKGCGAGCNSGGNVDDSDCGGGGGLTSLSNNPPLAQPTPENTAGAGDQPPPPGPAWGPRPSLSGSGDGRPPPLLQWPPPRLPGPSPASPALPEGPRPSRPPGPGLLSSEGPSGKWSLGGRKGLGGSDGEPASGSPKGSTPKSQAPLDLSLSPDISTEASPPRTVQDIPCLDSSAPETGTPTGALGDWPAPAEERESPAAQPLLEHQY", "length": 2041, "header": "tr|A0AAA9RUK5-1|E1BCD5_BOVIN Computationally mapped isoform of Pecanex-like protein OS=Bos taurus OX=9913 GN=PCNX3 PE=3 SV=1 CANONICAL=E1BCD5-1" }, "locus": { "chromosome": "29", "start_pos": 43815200, "end_pos": 43796881, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117144.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117144.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074756.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074756.1" } ] } }, { "isoform_ac": "A0AAA9SIV4-1", "url": "https://www.uniprot.org/uniprotkb/E1BCD5/entry#A0AAA9SIV4-1", "sequence": { "sequence": "MGSQVLQILRQGVWASLTGGWFFDPHQSTFSNCFHLYVWIFLLTFPFLLYMVLPPSLMVAGVYCLVVAVIFATIKTVNYRLHAMFDQGEIVEKRNSTMGEPEEEPAQGDNNLPRDPGVEMTVFRKVSSTPPVRCSSQHSVFGFNQVSELLPRIEDSGPLRDIKELVREQGSNNVIVTSADREMLKLSSQEKLIGDLPQTPPGAAPDPSLPSTDSSERSPLAGDGAPWSGGSVADTPMSPLLKGSLSQELSKSFLTLTRPERALVRTSSRREQRRGAGGYQPLDRRGSGDPTPQKAGSSDSCFSGTDRETLSSFKSEKTNSTHLDSPPGGQAPEGSDTDPPSEAELPASPDAGVPSDDTLRSFDTVVGAGTPPGPAEPLLVVRPKDLALLRPSKRRPPVRRHSPATGRAPRRPLLEGRGFFEDDDTSEGSELSPASSLRSQRRYSTDSSSSTSCYSPASSRGAAGGARKRRAPHGAEEGMAVPPKRPYGTQRTPSTASAKTHARVLSMDGAGGDALRGPPAGSKAELEAQAGVELAAAEPTVLAAEARRGPAANQPGWRGELREEGALGGAAEETGKRDHSSNVRRAQAIRRRHNAGSNPTPPASVMGSPPSLQEAQRGRAASHSRALTLPSALHFASSLLLTRAGANVHEACTFDDTSEGAVHYFYDESGVRRSYTFGLAGGGYENPVGQQGEQAANGAWDRHSHSSSFHSADVPEATGGLNLLQPRPVVLQGMQVRRVPLEIPEEQTLMEEAPPRAQHSYKYWLLPGRWTSVRYERLALLALLDRTRGLLENILGVGLSSLVAFLGYLLLLKGFFTDIWVFQFCLVIASCQYSLLKSVQPDAASPMHGHNWVIAYSRPVYFCICCLLIWLLDALGSAQPFPPVSLYGLTLFSASFFFCARDVATVFTLCFPFVFLLGLLPQVNTCLMYLLEQIDMHGFGGTAATSPLTAVFSLSRSLLAAALLYGFCLGAIKSPWPEQHVPVIFSVFCGLLVALSYHLSRQSSDPTVLWSLVRSKLFPELEERSLETARAEPPDPLPEKMRQSVREVLHSDLVMCVVIAVLTFAISASTVFIALKSVLGFVLYALAGAVGFFTHYLLPQLRKQLPWFCLSQPVLKPLEYSQYEVRGAAQVMWFEKLYAGLQCVEKYLIYPAVVLNALTVDAHTVVSHPDKFCLYCRALLMTVAGLKLLRSAFCCPPQQYLTLAFTVLLFHFDYPRLSQGFLLDYFLMSLLCSKLWDLLYKLRFVLTYIAPWQITWGSAFHAFAQPFAVPHSAMLFVQALLSALFSTPLNPLLGSAVFIMSYARPLKFWERDYNTKRVDHSNTRLVTQLDRNPGADDNNLNSIFYEHLTRSLQHTLCGDLVLGRWGNYGPGDCFVLASDYLNALVHLIEVGNGLVTFQLRGLEFRGTYCQQREVEAITEGVEEDEGCCCCEPGHLPRVLSFNAAFGQRWLAWEVTASKYVLEGYSISDNNAASMLQVFDLRKILVTYYVRSIIYYVSRSPKLEAWLSHEGIATALRPVRAPGYADSDPTFSLSVDEDYDLRLSGLSLPSFCAVHLEWIQYCASRRSQPVDQDWNSPLVTLCFGLCVLGRRALGTASHSMSASLEPFLYGLHALFKGDFRITSPRDEWVFADMDLLHRVVAPGVRMALKLHQDHFTSPDEYEEPAALYDAIAANEERLVISHEGDPAWRSAILSNTPSLLALRHVLDDASDEYKIIMLNRRHLSFRVIKVNRECVRGLWAGQQQELVFLRNRNPERGSIQNAKQALRNMINSSCDQPLGYPIYVSPLTTSLAGSHPQLRALWGGPVSLGAIARWLLRSWERLHKGCGAGCNSGGNVDDSDCGGGGGLTSLSNNPPLAQPTPENTAGEWARPS", "length": 1871, "header": "tr|A0AAA9SIV4-1|E1BCD5_BOVIN Computationally mapped isoform of Pecanex-like protein OS=Bos taurus OX=9913 GN=PCNX3 PE=3 SV=2 CANONICAL=E1BCD5-1" }, "locus": { "chromosome": "29", "start_pos": 43814567, "end_pos": 43796881, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129005.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129005.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083856.2", "url": "https://www.ensembl.org/id/ENSBTAP00000083856.2" } ] } }, { "isoform_ac": "E1BCD5-1", "url": "https://www.uniprot.org/uniprotkb/E1BCD5/entry#E1BCD5-1", "sequence": { "sequence": "MGSQVLQILRQGVWASLTGGWFFDPHQSTFSNCFHLYVWIFLLTFPFLLYMVLPPSLMVAGVYCLVVAVIFATIKTVNYRLHAMFDQGEIVEKRNSTMGEPEEEPAQGDNNLPRDPGVEMTVFRKVSSTPPVRCSSQHSVFGFNQVSELLPRIEDSGPLRDIKELVREQGSNNVIVTSADREMLKLSSQEKLIGDLPQTPPGAAPDPSLPSTDSSERSPLAGDGAPWSGGSVADTPMSPLLKGSLSQELSKSFLTLTRPERALVRTSSRREQRRGAGGYQPLDRRGSGDPTPQKAGSSDSCFSGTDRETLSSFKSEKTNSTHLDSPPGGQAPEGSDTDPPSEAELPASPDAGVPSDDTLRSFDTVVGAGTPPGPAEPLLVVRPKDLALLRPSKRRPPVRRHSPATGRAPRRPLLEGRGFFEDDDTSEGSELSPASSLRSQRRYSTDSSSSTSCYSPASSRGAAGGARKRRAPHGAEEGMAVPPKRPYGTQRTPSTASAKTHARVLSMDGAGGDALRGPPAGSKAELEAQAGVELAAAEPTVLAAEARRGPAANQPGWRGELREEGALGGAAEETGKRDHSSNVRRAQAIRRRHNAGSNPTPPASVMGSPPSSLQEAQRGRAASHSRALTLPSALHFASSLLLTRAGANVHEACTFDDTSEGAVHYFYDESGVRRSYTFGLAGGGYENPVGQQGEQAANGAWDRHSHSSSFHSADVPEATGGLNLLQPRPVVLQGMQVRRVPLEIPEFDLLDQDSLHESQEQTLMEEAPPRAQHSYKYWLLPGRWTSVRYERLALLALLDRTRGLLENILGVGLSSLVAFLGYLLLLKGFFTDIWVFQFCLVIASCQYSLLKSVQPDAASPMHGHNWVIAYSRPVYFCICCLLIWLLDALGSAQPFPPVSLYGLTLFSASFFFCARDVATVFTLCFPFVFLLGLLPQVNTCLMYLLEQIDMHGFGGTAATSPLTAVFSLSRSLLAAALLYGFCLGAIKSPWPEQHVPVIFSVFCGLLVALSYHLSRQSSDPTVLWSLVRSKLFPELEERSLETARAEPPDPLPEKMRQSVREVLHSDLVMCVVIAVLTFAISASTVFIALKSVLGFVLYALAGAVGFFTHYLLPQLRKQLPWFCLSQPVLKPLEYSQYEVRGAAQVMWFEKLYAGLQCVEKYLIYPAVVLNALTVDAHTVVSHPDKFCLYCRALLMTVAGLKLLRSAFCCPPQQYLTLAFTVLLFHFDYPRLSQGFLLDYFLMSLLCSKLWDLLYKLRFVLTYIAPWQITWGSAFHAFAQPFAVPHSAMLFVQALLSALFSTPLNPLLGSAVFIMSYARPLKFWERDYNTKRVDHSNTRLVTQLDRNPGADDNNLNSIFYEHLTRSLQHTLCGDLVLGRWGNYGPGDCFVLASDYLNALVHLIEVGNGLVTFQLRGLEFRGTYCQQREVEAITEGVEEDEGCCCCEPGHLPRVLSFNAAFGQRWLAWEVTASKYVLEGYSISDNNAASMLQVFDLRKILVTYYVRSIIYYVSRSPKLEAWLSHEGIATALRPVRAPGYADSDPTFSLSVDEDYDLRLSGLSLPSFCAVHLEWIQYCASRRSQPVDQDWNSPLVTLCFGLCVLGRRALGTASHSMSASLEPFLYGLHALFKGDFRITSPRDEWVFADMDLLHRVVAPGVRMALKLHQDHFTSPDEYEEPAALYDAIAANEERLVISHEGDPAWRSAILSNTPSLLALRHVLDDASDEYKIIMLNRRHLSFRVIKVNRECVRGLWAGQQQELVFLRNRNPERGSIQNAKQALRNMINSSCDQPLGYPIYVSPLTTSLAGSHPQLRALWGGPVSLGAIARWLLRSWERLHKGCGAGCNSGGNVDDSDCGGGGGLTSLSNNPPLAQPTPENTAGAGDQPPPPGPAWGPRPSLSGSGDGRPPPLLQWPPPRLPGPSPASPALPEGPRPSRPPGPGLLSSEGPSGKWSLGGRKGLGGSDGEPASGSPKGSTPKSQAPLDLSLSPDISTEASPPRTVQDIPCLDSSAPETGTPTGALGDWPAPAEERESPAAQPLLEHQY", "length": 2042, "header": "tr|E1BCD5-1|E1BCD5_BOVIN Isoform 1 of Pecanex-like protein OS=Bos taurus OX=9913 GN=PCNX3 PE=3 SV=3 CANONICAL=E1BCD5-1" }, "locus": { "chromosome": "29", "start_pos": 43815200, "end_pos": 43796881, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004893.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004893.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004893.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004893.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 600, "start_aa": "Thr", "end_pos": 600, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr600", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AU25-1", "protein_name": "Pecanex-like protein", "gene_name": "Pcnx3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGSQVLQILRQGVWASLTGGWFFDPHQSTFSNCFHLYVWIFLLIFPFLLYMVLPPSLMVAGVYCLVVAVIFATIKTVNYRLHAMFDQGEIVEKRNSTMGEQEEEAAQGESSLPRDPGVEMTVFRKVSSTPPVRCSSQHSVFGFNQVSELLPRMEDSGPLRDIKELVREQGSNNVIVTSADREMLKLSSQENLIGDLPQTPPGVVPDPSLPSTDSSERSPMAGDAVPWGGSSVADTPMSPLLKGSLSQELSKSFLTLTRPDRALVRTSSRREQCRGTGGYQPLDRRGSGDPLPQKAGSSDSCFSGTDRETLSSFRSEKTNSTHLDSPPGGHAPEGSDTDPPSEAELPASPDAGVPSDDTLRSFDTVIGAGTPPGQTEPLLVVRPKDLALLRPNKRRPPMRGHSPPGRTPRRPLLEGSGFFEDEDTSEGSELSPASSLRSQRRYSTDSSSSTSCYSPESSQGAAGGPRKRRAPHGAEEGTAVPPKRPYGTQRTPSTASAKTHARVLSMDGAGGDVLRAPLAGSKAELEAQPGMELAAGEPAMLPPEARRGPAANQPGWRGELQEEGAVGGAPEETGQRECTSNVRRAQAIRRRHNAGSNPTPPASVMGSPPSSLQEAQRGRAASHSRALTLPSALHFASSLLLTRAGPNVHEASNFDDTSEGAVHYFYDESGVRRSYTFGLAGGGYENPVSQPGEQAANGAWDRHSHSSSFHSADVPEATGGLNLLQPRPVVLQGMQVRRVPLEIPEEQTLMEEAPPRAQHSYKYWFLPGRWTSVRYERLALLALLDRTRGIMENIFGVGLSSLVAFLGYLLLLKGFFTDIWVFQFCLVIASCQYSLLKVRPGSPNPQLSWGHNWVIAYSRPVYFCICCLLIWLLDALGTAQPFPPVSLYGLTLFSASFFFCARDVATVFTLCFPFVFLLGLLPQVNTCLMYLLEQIDMHGFGGTAATSPLTAVFSLTRSLLAAALLYGFCLGAIKTPWPEQHVPVLFSVFCGLLVALSYHLSRQSSDPTVLWSLVRSKLFPELEERSLETARAEPPDPLPEKMRQSVREVLHSDLVMCVVIAVLTFAISASTVFIALKSVLGFVLYALAGAVGFFTHYLLPQLRKQLPWFCLSQPVLKPLEYSQYEVRGAAQVMWFEKLYAGLQCVEKYLIYPAVVLNALTVEAHTVVNHPDKFCLYCRALLMTVAGLKLLRSAFCCPPQQYLTLAFTVLLFHFDYPRLSQGFLLDYFLMSLLCSKLWDLLYKLRFVLTYIAPWQITWGSAFHAFAQPFAVPHSAMLFLQALLSGLFSTPLNPLLGSAVFIMSYARPLKFWERDYNTKRVDHSNTRLVTQLDRNPGADDNNLNSIFYEHLTRSLQHTLCGDLVLGRWGNYGPGDCFVLASDYLNALVHLIEVGNGLVTFQLRGLEFRGTYCQQREVEAITEGVEEDEGCCCCEPGHLPRVLSFNAAFGQRWLAWEVTASKYVLEGYSISDNNAASMLQVFDLRKILVTYYVKSIIYYVSRSPKLETWLNHEGIAAALRPVRALGYADSDPTFSLSVDEDYDLRLSGLSLPSFCAVHLEWIQYCASRRSQPVDQDWNSPLVTLCFGLCVLGRRALGTASHSMSASLEPFLYGLHALFKGDFRITSPRDEWVFADMDLLHRVVAPGVRMALKLHQDHFTSPDEYEEPAALYDAIAANEERLVISHEGDPAWRSAILSNTPSLLALRHVMDDASDEYKIIMLNRRHLSFRVIKVNRECVRGLWAGQQQELVFLRNRNPERGSIQNAKQALRNMINSSCDQPLGYPIYVSPLTTSLAGSHPQLRALWGGPVSLGAIARWLLRSWERLHKGCGAGCNSGGNVDDSDCAGGGGLTSLSNNPPLAHPTPENTAGSSEQPLPPGPSWGPRPSLSGSGDGRPPPLLQWPPPRLPGPPPASPAPTEGPRPSRPPGPGLLNSEGPSGKWSLGGRKGLGGPDGEPASGSPKGGTPKSQAPLDLSLSPDVSSEASPARTTQDIPCLDSSVPESCTPSGAPGDWPVPVEERESPAAQPLLEHQY", "length": 2029 }, "evidence": [ { "id": "E1BCD5", "url": "https://omabrowser.org/oma/group/E1BCD5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RRK1-1", "protein_name": "Pecanex-like protein", "gene_name": "PCNX3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGSQVLQILRQGVWASLTGGWFFDPHQSTFSNCFHLYVWIFLLTFPFLLYMVLPPSLMVAGVYCLVVAVIFATIKTVNYRLHAMFDQGEIVEKRNSTMGDPEEEPAQGDSSLPRDPGVEMTVFRKVSSTPPVRCSSQHSVFGFNQVSELLPRMEDSGPLRDIKELVREQGSNNVIVTSADREMLKLSSQEKLIGDLPQTPPGAAPDPSLPSTDSSERSPLAGEGAPWSGSSVADTPMSPLLKGSLSQELSKSFLTLTRPDRALVRTSSRREQRRGAGGYQPLDRRGSGEPTPQKAGSSDSCFSGTDRETLSSFKSEKTNSTHLDSPPGGQAPEGSDTDPPSEAELPASPDAGVPSDDTLRSFDTVVGAGTPPGPAEPLLVVRPKDLALLRPSKRRPPLRRHSPAGRAPRRPLLEGGGFFEDDDTSEGSELSPASSLRSQRHYSTDSSSSTSCYSPESSRGAAGGPRKRRAPHGAEEGTAVPPKRPYGTQRTPSTASAKTHARVLSMDGAGGDVLRGPLAGSKAELEAQAGVELAAGEPAVLPAEARRGPAANQPGWRGELQEEGAVGGAAEETGKRDRSSSVRRTQAIRRRHNAGSNPTPPASVMGSPPSSLQEAQRGRAASHSRALTLPSALHFASSLLLTRAGATVHEACTFDDTSEGAVHYFYDESGVRRSYTFGLAGGGYENPVGQQGEQAANGAWDRHSHSSSFHSTDVPEAAGSLNLLQPRPVVLQGMQVRRVPLEIPEEQTLMEEAPPRAQHSYKYWLLPGRWTSVRYERLALLALLDRTRGLVENILGVGLSSLVAFLGYLLLLKGFFTDIWVFQFCLVIASCQYSLLKSVQPDAASPMHGHNWVIAYSRPVYFCICCLLIWLLDALGSAQPFPPVSLYGLTLFSASFFFCARDVATVFTLCFPFVFLLGLLPQVNTCLMYLLEQIDMHGFGGTAATSPLTAVFSLSRSLLAAALLYGFCLGAIKTPWPEQHVPVLFSVFCGLLVALSYHLSRQSSDPTVLWSLIRSKLFPELEERSLETARAEPPDPLPDKMRQSVREVLHSDLVMCVVIAVLTFAISASTVFIALKSVLGFVLYALAGAVGFFTHYLLPQLRKQLPWFCLSQPVLKPLEYSQYEVRGAAQVMWFEKLSAGLQCMEKYLIYPAVVLNALTVDAHTVVSHPDKFCLYCRALLMTVAGLKLLRSAFCCPPQQYLTLAFTVLLFHFDYPRLSQGFLLDYFLMSLLCSKLWDLLYKLRFVLTYIAPWQITWGSAFHAFAQPFAVPHSAMLFVQALLSALFSTPLNPLLGSAVFIMSYARPLKFWERDYNTKRVDHSNTRLVTQLDRNPGADDNNLNSIFYEHLTRSLQHTLCGDLVLGRWGNYGPGDCFVLASDYLNALVHLIEVGNGLVTFQLRGLEFRGTYCQQREVEAITEGVEEDEGCCCCEPGHLPRVLSFNAAFGQRWLAWEVTASKYVLEGYSISDNNAASMLQVFDLRKILITYYVKSIIYYVSRSPKLEAWLSHEGIATALRPVRAPGYADSDPTFSLSVDEDYDLRLSGLSLPSFCAVHLEWIQYCASRRGQPVDQDWNSPLVTLCFGLCVLGRRALGTASHSMSASLEPFLYGLHALFKGDFRITSPRDEWVFADMDLLHRVVAPGVRMALKLHQDHFTSPDEYEEPAALYDAIAANEERLVISHEGDPAWRSAILSNTPSLLALRHVLDDASDEYKIIMLNRRHLSFRVIKVNRECVRGLWAGQQQELVFLRNRNPERGSIQNAKQALRNMINSSCDQPLGYPIYVSPLTTSLAGSHPQLRALWGGPVSLGAIARWLLHSWERLHKGCGAGCNSGGNVDDSDCGGGGGGSGLTSLASNPPLAQPTPENTAGGGDQPLPPGPAWGPRPSLSGSGDGRPPPLLQWPPPRLPGPSPASPAPTEGPRPSRPPGPGLLSSEGPSGKWSLGGRKGLGGSEGEPASGSPKGSTPKSQAPLDLSLSPDINTDASPSRAAQDFPCLDGSAAESGTPTGALGDWPAPAEEQESPAAQPLLEHQY", "length": 2031 }, "evidence": [ { "id": "E1BCD5", "url": "https://omabrowser.org/oma/group/E1BCD5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8VI59-1", "protein_name": "Pecanex-like protein 3", "gene_name": "Pcnx3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSQVLQILRQGVWASLTGGWFFDPHQSTFSNCFHLYVWIFLLIFPFLLYMVLPPSLMVAGVYCLVVAVIFATIKTVNYRLHAMFDQGEIVEKRNSTMGEQEEEAAQGESSLPRDPGVEMTVFRKVSSTPPVRCSSQHSVFGFNQVSELLPRMEDSGPLRDIKELVREQGSNNVIVTSADREMLKLSSQEKLIGDLPQTPPGVVPDPSLPSTDSSERSPMAGDGVPWGGSGVADTPMSPLLKGSLSQELSKSFLTLTRPDRALVRTSSRREQCRGTGGYQPLDRRGSGDPMPQKAGSSDSCFSGTDRETLSSFKSEKTNSTHLDSPPGGHAPEGSDTDPPSEAELPASPDAGVPSDDTLRSFDTVIGAGTPPGQTEPLLVVRPKDLALLRPSKRRPPMRGHSPPGRTPRRPLLEGSGFFEDEDTSEGSELSPASSLRSQRRYSTDSSSSTSCYSPESSQGAAGGPRKRRAPHGAEEGTAVPPKRPYGTQRTPSTASAKTHARVLSMDGAGGDVLRAPLAGSKAELEAQPGMELAAGEPAVLPPEARRGPAANQPGWRGELQEEGAVGGAPEETGQRECTSNVRRAQAIRRRHNAGSNPTPPASVMGSPPSSLQEAQRGRAASHSRALTLPSALHFASSLLLTRAGPNVHEASNFDDTSEGAVHYFYDESGVRRSYTFGLAGGGYENPVSQPGEQAANGAWDRHSHSSSFHSADVPEATGGLNLLQPRPVVLQGMQVRRVPLEIPEEQTLMEEAPPRAQHSYKYWFLPGRWTSVRYERLALLALLDRTRGVMENIFGVGLSSLVAFLGYLLLLKGFFTDIWVFQFCLVIASCQYSLLKSVQPDAASPMHGHNWVIAYSRPVYFCICCLLIWLLDALGTAQPFPPVSLYGLTLFSASFFFCARDVATVFTLCFPFVFLLGLLPQVNTCLMYLLEQIDMHGFGGTAATSPLTAVFSLTRSLLAAALLYGFCLGAIKTPWPEQHVPVLFSVFCGLLVAMSYHLSRQSSDPTVLWSLVRSKLFPELEERSLETARVEPPDPLPEKMRQSVREVLHSDLVMCVVIAVLTFAVSASTVFIALKSVLGFVLYALAGAVGFFTHYLLPQLRKQLPWFCLSQPVLKPLEYSQYEVRGAAQVMWFEKLYAGLQCAEKYLIYPAVVLNALTVDAHTVVSHPDKFCLYCRALLMTVAGLKLLRSAFCCPPQQYLTLAFTVLLFHFDYPRLSQGFLLDYFLMSLLCSKLWDLLYKLRFVLTYIAPWQITWGSAFHAFAQPFAVPHSAMLFLQALLSGLFSTPLNPLLGSAVFIMSYARPLKFWERDYNTKRVDHSNTRLVTQLDRNPGADDNNLNSIFYEHLTRSLQHTLCGDLVLGRWGNYGPGDCFVLASDYLNALVHLIEVGNGLITFQLRGLEFRGTYCQQREVEAITEGVEEDEGCCCCEPGHLPRVLSFNAAFGQRWLAWEVTASKYVLEGYSISDNNAASMLQVFDLRKILVTYYVKSIIYYVSRSPKLETWLNHEGIAAALRPVRALGYADSDPTFSLSVDEDYDLRLSGLSLPSFCAVHLEWIQYCASRRSQPVDQDWNSPLVTLCFGLCVLGRRALGTASHSMSASLEPFLYGLHALFKGDFRITSPRDEWVFADMDLLHRVVAPGVRMALKLHQDHFTSPDEYEEPAALYDAIAANEERLVISHEGDPAWRSAILSNTPSLLALRHVMDDASDEYKIIMLNRRHLSFRVIKVNRECVRGLWAGQQQELVFLRNRNPERGSIQNAKQALRNMINSSCDQPLGYPIYVSPLTTSLAGSHPQLRALWGGPVSLGAIARWLLRSWERLHKGCGAGCNSGGNVDDSDCGGGGGLTSLSNHPPLAHPTPENAAGSSEQPLPPGPSWGPRPSLSGSGDGRPPPLLQWPPPRLPGPPPASPAPTEGPRPSRPSGPALLNSEGPSGKWSLGGRKGLGGPDGEPASGSPKGGTPKSQAPLDLSLSPDVSSEASPARTTQDLPCLDSSIPEGCTPSGAPGDWPVPAEERESPAAQPLLEHQY", "length": 2028 }, "evidence": [ { "id": "E1BCD5", "url": "https://omabrowser.org/oma/group/E1BCD5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H6A9-1", "protein_name": "Pecanex-like protein 3", "gene_name": "PCNX3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGSQVLQILRQGVWASLTGGWFFDPHQSTFSNCFHLYVWIFLLIFPFLLYMVLPPSLMVAGVYCLVVAVIFATIKTVNYRLHAMFDQGEIVEKRSSTMGELEEEPAQGDSNPPRDPGVEMTVFRKVSSTPPVRCSSQHSVFGFNQVSELLPRMEDSGPLRDIKELVREQGSNNVIVTSADREMLKLSSQEKLIGDLPQTPPGAVPDPSLASTDSSEPSPLAGDGAPWSGSSMADTPMSPLLKGSLSQELSKSFLTLTQPDRALVRTSSRREQRRGAGGYQPLDRRGSGEPTPQKAGSSDSCFSGTDRETLSSFKSEKTNSTHLDSPPGGPAPEGSDTDPPSEAELPASPDAGVPSDDTLRSFDTVIGAGTPPGLAEPLLVVRPKDLALLRPSKRQPPLRRHSPPGRAPRRPLLEGGGFFEDEDTSEGSELSPASSLRSQRRYSTDSSSSTSCYSPESSRGAAGGPRKRRAPHGAEEGTAVPPKRPYGTQRTPSTASAKTHARVLSMDGAGGDVLRPPLAGCKAELEAQVGVEQAASEPVVLPAEARRGPAANQPGWRGELQEEGAVGGAAEETGRRDRSSSVRRTQAIRRRHNAGSNPTPPASVMGSPPSSLQEAQRGRAASHSRALTLPSALHFASSLLLTRAGANVHEACTFDDTSEGAVHYFYDESGVRRSYTFGLAGGGYENPVGQQGEQTANGAWDRHSHSSSFHSADVPEATGGLNLLQPRPVVLQGMQVRRVPLEIPEEQTLMEEAPPRAQHSYKYWLLPGRWTSVRYERLALLALLDRTRGVLENIFGVGLSSLVAFLGYLLLLKGFFTDIWVFQFCLVIASCQYSLLKSVQPDAASPMHGHNWVIAYSRPVYFCICCLLIWLLDALGSAQPFPPVSLYGLTLFSASFFFCARDVATVFTLCFPFVFLLGLLPQVNTCLMYLLEQIDMHGFGGTAATSPLTAVFSLSRSLLAAALLYGFCLGAIKTPWPEQHVPVLFSVFCGLLVALSYHLSRQSSDPTVLWSLIRSKLFPELEERSLETARAEPPDPLPDKMRQSVREVLHSDLVMCVVIAVLTFAISASTVFIALKSVLGFVLYALAGAVGFFTHYLLPQLRKQLPWFCLSQPVLKPLEYSQYEVRGAAQVMWFEKLYAGLQCVEKYLIYPAVVLNALTVDAHTVVSHPDKYCFYCRALLMTVAGLKLLRSAFCCPPQQYLTLAFTVLLFHFDYPRLSQGFLLDYFLMSLLCSKLWDLLYKLRFVLTYIAPWQITWGSAFHAFAQPFAVPHSAMLFVQALLSGLFSTPLNPLLGSAVFIMSYARPLKFWERDYNTKRVDHSNTRLVTQLDRNPGADDNNLNSIFYEHLTRSLQHTLCGDLVLGRWGNYGPGDCFVLASDYLNALVHLIEVGNGLVTFQLRGLEFRGTYCQQREVEAITEGVEEDEGCCCCEPGHLPRVLSFNAAFGQRWLAWEVTASKYVLEGYSISDNNAASMLQVFDLRKILITYYVKSIIYYVSRSPKLEVWLSHEGITAALRPVRVPGYADSDPTFSLSVDEDYDLRLSGLSLPSFCAVHLEWIQYCASRRSQPVDQDWNSPLVTLCFGLCVLGRRALGTASHSMSASLEPFLYGLHALFKGDFRITSPRDEWVFADMDLLHRVVAPGVRMALKLHQDHFTSPDEYEEPAALYDAIAANEERLVISHEGDPAWRSAILSNTPSLLALRHVLDDASDEYKIIMLNRRHLSFRVIKVNRECVRGLWAGQQQELVFLRNRNPERGSIQNAKQALRNMINSSCDQPLGYPIYVSPLTTSLAGSHPQLRALWGGPISLGAIAHWLLRTWERLHKGCGAGCNSGGNVDDSDCSGGGGLTSLSNNPPVAHPTPENTAGNGDQPLPPGPGWGPRSSLSGSGDGRPPPLLQWPPPRLPGPPPASPIPTEGPRTSRPPGPGLLSSEGPSGKWSLGGRKGLGGSDGEPASGSPKGGTPKSQAPLDLSLSLSLSLSPDVSTEASPPRASQDIPCLDSSAPESGTPMGALGDWPAPIEERESPAAQPLLEHQY", "length": 2034 }, "evidence": [ { "id": "E1BCD5", "url": "https://omabrowser.org/oma/group/E1BCD5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BCD5", "url": "https://www.uniprot.org/uniprotkb/E1BCD5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1784, "end_pos": 1786, "annotation": "n_glycosylation_sequon" }, { "start_pos": 319, "end_pos": 321, "annotation": "n_glycosylation_sequon" }, { "start_pos": 95, "end_pos": 97, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCD5" }, { "id": "PF05041", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05041" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Pecanex C-terminal", "eco_id": "ECO_0000259", "start_pos": 1585, "end_pos": 1809, "start_aa": "Gln", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 600 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1784, "end_pos": 1786 }, { "start_pos": 319, "end_pos": 321 }, { "start_pos": 95, "end_pos": 97 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BC04-1", "uniprot_ac": "E1BC04", "uniprot_id": "E1BC04_BOVIN", "mass": { "chemical_mass": 79438.0, "monoisotopic_mass": 79438.0 }, "refseq": { "ac": "NP_001098726", "name": "consortin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098726" }, "gene_names": [ { "name": "CNST", "type": "recommended", "evidence": [ { "id": "E1BC04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC04" } ] }, { "name": "CNST", "type": "synonym", "evidence": [ { "id": "NP_001098726", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098726" } ] } ], "protein_names": [ { "name": "Consortin, connexin sorting protein", "type": "synonym", "evidence": [ { "id": "E1BC04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC04/entry#names_and_taxonomy" } ] }, { "name": "consortin", "type": "synonym", "evidence": [ { "id": "NP_001098726", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098726" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BC04", "url": "https://www.uniprot.org/uniprotkb/E1BC04" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CNST", "url": "https://www.uniprot.org/uniprotkb/E1BC04", "locus": { "chromosome": "16", "start_pos": 30695682, "end_pos": 30802322, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000511", "url": "https://www.ensembl.org/id/ENSBTAG00000000511" } ] } } ], "crossref": [ { "id": "E1BC04", "url": "https://alphafold.ebi.ac.uk/entry/E1BC04", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000511", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000511", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "541076", "url": "https://www.ncbi.nlm.nih.gov/gene/541076", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042318", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042318", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054132", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054132", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541076", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541076", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AKFCTTH", "url": "https://omabrowser.org/oma/group/AKFCTTH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BC04", "url": "https://www.orthodb.org/?gene=E1BC04", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28581", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28581", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28581:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28581:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15281", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15281", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22883", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22883", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001098726", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098726", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RXI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP38", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU23-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC04", "url": "https://www.uniprot.org/uniprotkb/E1BC04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC04-1", "url": "https://www.uniprot.org/uniprotkb/E1BC04-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDDSETPAYNLQIEPQDGCHPGDGVESKVTCLPSASDENENQLDGDGLELLTSSGSAMGKPEVLEQDSLNNNESCTPSCEVAASENSENISCESPKDGQVFLRKDHKIPGSRSPRSKRGTVKKIPQGLSSEDSTPLMQENILHVVTHAVSDEESAEVNANDQLEASKLVLQSLFSLIRGEVEQLDSRALPLCLHQIAESYFQEEDYEKAMKFIQLERLYHEQLLANLSAIQEQWETKWKTVQPHTVTPLRNSEKGFNGEDFERLAKFCATHQDPLLSKDKIAAVQKSLGRKCFTQLIVSEDPKERGATAKELESEICLGMESGKESQHKEETLESSPCCNEMVRQADPRSLPVTARKGHTEEPLCSSEATQELHAQPSESAGSRSSPHSSGNAPEDDSRLQLAQTEACQDVAETERIAKNPKVSSQSVTEPLILPGSDHIPPALISEGKYSQRKELRLPLRDASEALPTDQLENNELNELQQPDLTERDGKSPQGQADSEGSESVLCENNPVSDLSTVLPEVYMAPEEQGDKEEQVSKETDDYLNSLLGGCLKDTEDSLSYEDNQEEDSDFLQDLSPEEASYSLQENLPSDESCLSLDDLAKRIEIAEVVPAEGLVSILKKRNDSVGDRPAQMQQKPSKRRVRFQEIDDSLDQDEVGGGSCILLVLLCIVTVLLSVGGTALYCTFGDMGSPVCTDFADNVDFYYTKLLQGIAELKHWIYLS", "length": 721, "header": "tr|E1BC04-1|E1BC04_BOVIN Isoform 1 of Consortin, connexin sorting protein OS=Bos taurus OX=9913 GN=CNST PE=4 SV=1 CANONICAL=E1BC04-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXI9-1", "url": "https://www.uniprot.org/uniprotkb/E1BC04/entry#A0AAA9RXI9-1", "sequence": { "sequence": "MDDSETPAYNLQIEPQDGCHPGDGVESKVTCLPSASDENENQLDGDGLELLTSSGSAMGKPEVLEQDSLNNNESCTPSCEVAASENSENISCESPKDGQVFLRKDHKIPGSRSPRSKRGTVKKIPQDSRVLFPGGGL", "length": 137, "header": "tr|A0AAA9RXI9-1|E1BC04_BOVIN Computationally mapped isoform of Consortin, connexin sorting protein OS=Bos taurus OX=9913 GN=CNST PE=4 SV=1 CANONICAL=E1BC04-1" }, "locus": { "chromosome": "16", "start_pos": 30770646, "end_pos": 30733654, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135461.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135461.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075920.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075920.1" } ] } }, { "isoform_ac": "A0AAA9SP38-1", "url": "https://www.uniprot.org/uniprotkb/E1BC04/entry#A0AAA9SP38-1", "sequence": { "sequence": "MDDSETPAYNLQIEPQDGCHPGDGVESKVTCLPSASDENENQLDGDGLELLTSSGSAMGKPEVLEQDSLNNNESCTPSCEVAASENSENISCESPKDGQVFLRKDHKIPGSRSPRSKRGTVKKIPQGLSSEDSTPLMQENILHVVTHAVSDEESAEVNANDQLEASKLVLQSLFSLIRGEVEQLDSRALPLCLHQIAESYFQEEDYEKAMKFIQLERLYHEQLLANLSAIQEQWETKWKTVQPHTVTPLRNSEKGFNGEDFERLAKFCATHQDPLLSKDKIAAVQKSLGRKCFTQLIVSEDPKERGATAKELESEICLGMESGKESQHKEETLESSPCCNEMVRQADPRSLPVTARKGHTEEPLCSSEATQELHAQPSESAGSRSSPHSSGNAPEDDSRLQLAQTEACQDVAETERIAKNPKVSSQSVTEPLILPGSDHIPPALISEGKYSQRKELRLPLRDASEALPTDQLENNELNELQQPDLTERDGKSPQGQADSEGSESVLCENNPVSDLSTVLPEVYMAPEEQGDKEEQVSKETDDYLNSLLGGCLKDTEDSLSYEDNQEEDSDFLQDLSPEEASYSLQENLPSDESCLSLDDLAKRIEIAEVVPAEGLVSILKKRNDSVGDRPAQMQQKPSKRRVRFQEIDDSLDQDGNT", "length": 657, "header": "tr|A0AAA9SP38-1|E1BC04_BOVIN Computationally mapped isoform of Consortin, connexin sorting protein OS=Bos taurus OX=9913 GN=CNST PE=4 SV=1 CANONICAL=E1BC04-1" }, "locus": { "chromosome": "16", "start_pos": 30770646, "end_pos": 30695764, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087621.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087621.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088079.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088079.1" } ] } }, { "isoform_ac": "A0AAA9SU23-1", "url": "https://www.uniprot.org/uniprotkb/E1BC04/entry#A0AAA9SU23-1", "sequence": { "sequence": "MDDSETPAYNLQIEPQDGCHPGDGVESKVTCLPSASDENENQLDGDGLELLTSSGSAMGKPEVLEQDSLNNNESCTPSCEVAASENSENISCESPKDGQVFLRKDHKIPGSRSPRSKRGTVKKIPQGILF", "length": 130, "header": "tr|A0AAA9SU23-1|E1BC04_BOVIN Computationally mapped isoform of Consortin, connexin sorting protein OS=Bos taurus OX=9913 GN=CNST PE=4 SV=2 CANONICAL=E1BC04-1" }, "locus": { "chromosome": "16", "start_pos": 30770646, "end_pos": 30770257, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111257.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111257.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087510.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087510.2" } ] } }, { "isoform_ac": "E1BC04-1", "url": "https://www.uniprot.org/uniprotkb/E1BC04/entry#E1BC04-1", "sequence": { "sequence": "MDDSETPAYNLQIEPQDGCHPGDGVESKVTCLPSASDENENQLDGDGLELLTSSGSAMGKPEVLEQDSLNNNESCTPSCEVAASENSENISCESPKDGQVFLRKDHKIPGSRSPRSKRGTVKKIPQGLSSEDSTPLMQENILHVVTHAVSDEESAEVNANDQLEASKLVLQSLFSLIRGEVEQLDSRALPLCLHQIAESYFQEEDYEKAMKFIQLERLYHEQLLANLSAIQEQWETKWKTVQPHTVTPLRNSEKGFNGEDFERLAKFCATHQDPLLSKDKIAAVQKSLGRKCFTQLIVSEDPKERGATAKELESEICLGMESGKESQHKEETLESSPCCNEMVRQADPRSLPVTARKGHTEEPLCSSEATQELHAQPSESAGSRSSPHSSGNAPEDDSRLQLAQTEACQDVAETERIAKNPKVSSQSVTEPLILPGSDHIPPALISEGKYSQRKELRLPLRDASEALPTDQLENNELNELQQPDLTERDGKSPQGQADSEGSESVLCENNPVSDLSTVLPEVYMAPEEQGDKEEQVSKETDDYLNSLLGGCLKDTEDSLSYEDNQEEDSDFLQDLSPEEASYSLQENLPSDESCLSLDDLAKRIEIAEVVPAEGLVSILKKRNDSVGDRPAQMQQKPSKRRVRFQEIDDSLDQDEVGGGSCILLVLLCIVTVLLSVGGTALYCTFGDMGSPVCTDFADNVDFYYTKLLQGIAELKHWIYLS", "length": 721, "header": "tr|E1BC04-1|E1BC04_BOVIN Isoform 1 of Consortin, connexin sorting protein OS=Bos taurus OX=9913 GN=CNST PE=4 SV=1 CANONICAL=E1BC04-1" }, "locus": { "chromosome": "16", "start_pos": 30770646, "end_pos": 30706518, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055849.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055849.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051991.2", "url": "https://www.ensembl.org/id/ENSBTAP00000051991.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:541076", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541076", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BRF4-1", "protein_name": "Consortin, connexin sorting protein", "gene_name": "CNST", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDDRETPTYNLQREPQDGCHPGDGVESLVTCLPSASDENENQLDGDGCERLTSSDGAMGKAGVFEQDTLNNNESCSPSCEVAASENSENPSCEVPKDGQAFLGKDKEIPGKRSLKSKRGTVKKIPQGFSSGDTTHLMQENRLHEASHAVSDEEPAEVNANDQLEGPKLILQSLFSLIRGEVEQLDSRALPLFLHQIAESYFQEEDYEKAMKFIQLERLYHEQLLTNLSAIQEQWETKWKTVEPHAVTSLRNSEKGFNGEDFERLTKFCTTHQDPLLSKCKIAAVQKSLGRKCFTQLVVSEDPKERGATAKEPESETCLGMDSGKEGQHNKETRESSPCCNQVDRQADPPGLVVTAGKSHTEEPLCSTEATLELHAQPLESAGSRSGPHSAENACEDNSRLQLAHTEAGQDVAGSEGIAEDAKVSSESVIVPLILPGSDHIPPVLISEGKYSQTRRKELHLPLQDASEALPTDQLENNELTELQQPDLTDSDGKSPQRQTDSQGSENVLCENNQVSDLSTVLPEVYMAPEEQGDKDDQVSKETEDYLNSLLEGCLKDSEDSLLCEDNQEEDSDLQDLSPEEASYSLQESLPSDESSLSLDDLAKRIEIAEVVPAEGLVSILKKRNDTVGDQPAQMQQKPSKRRVRFQEIDDSLDQDEVGSGSCILLVLLCIATVFLSIGGTALYCTFGDLESPVCVDFADNVDFYYTKLLQGMAELKHWIYLS", "length": 722 }, "evidence": [ { "id": "E1BC04", "url": "https://omabrowser.org/oma/group/E1BC04/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YDI4-1", "protein_name": "Consortin, connexin sorting protein", "gene_name": "CNST", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDDREFPPNDLQIISKDSLPADYRAERLTSHLVSSADENENQLDNDGNDVLTSSRIAMGRQDEGEQDSINNNENMDSGDCTPGYKESETERRSVNVHMDPQLEEKPITEKQPGGKRSPRSKRSSSKKSKGVPSVGTTAIKEENTLVTHTDSVHSEGAVEATENSHQKEQKQTLQSLFSLLREEVEQMDSKTLPLCLHQIAETYFQEEEYEKAMKFIQLERLYHEQLLANLSSIQEQWERKWKAAVSSPVRTLRNSAKELSSEELEKLTKVCSSHQQPQAPKNKPVVAENTSESGCLLKLIGSENVKEREAAAFKSGTETCPGIRPKKEDQQPSTRPSDEKQTEEQKEAVSLSVAAGKDHMEEQHRSAESALEPHTQSTGTVGRPSPGCLSSGDAGKDNSLLLRERQISKDAEKIEETAGEPGVKFSPGPMVDALVLTDADYMPADLVSTDKDAQADKNLLRSKLVASSSEIATGQLGNSDLNQQQKRPDDGDDEESPPDRTASSTCSESSKVSEHESTARSRVCKELQRAAGQEEKVKSEEREDVYLRFLNGNIIDTEESFANLANQEEFDTVPDISPERASYNSLEALSLDDSFSSLDELARRIEIAEIAPAEGLVSILKKRDDRDGKTVAQVQQRQTKRRVRFQEMEDTFDQDEVAGGSCILLVLLCIATVFLSIGGTALYCTFGDMESPVCTEFAANMDFYYTQILQRVEELKHWIAFS", "length": 722 }, "evidence": [ { "id": "E1BC04", "url": "https://omabrowser.org/oma/group/E1BC04/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZKK3-1", "protein_name": "Consortin, connexin sorting protein", "gene_name": "Cnst", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDDSDSPTYSLQIEPQDGCHPGDSVERRVTRLPSVSDENENQLAGDGPALLTTSDGAMGRAAVSEQDSLNNNESCLSSCEAAPRDNSEGPKDDPPSLGEDTKPPGKRSPRAKRGAPKSSAPPGDGVTQMPNAASQAAGEEEAAGVNANDPPKAAALQPLFSLIRGEVEQMDSRALPLFLHQVAETYFQEEDYEKAMKFIQLERLYHEQLLANLSAIQEQWETKWKSVQPSTKKPLRNSEKGFNGEDFEQLAKICTTHQDPLLSKLKIVPVEQSPGKKGFPRVTMSDEPMERGATAKEPEIETCPGTGPSGGRHEEEPQESSPDCPQMNWQTASPDLPGTAGKAHTEAEALPNTTLELHTQSPEAAGSRSGAAAAENACEDDSCVQAPPTEDHPDVARAPKEVPPSEPVAEPFPSGDIAPPGLISGGKYSQTHRKELCLPLQDTFEALPRDQHCNSEVAKPRQPDVTASDGKSAQSQTGLETGPESALCGDRKASDVSTLCPEVCMAPEERGDREEQVSKETEDYLNSLLEGCLKDVEDSLSYESIQDDDDSDLLQDLSPEEASYSLQENLPPEESALSLDDLAKKIEIAEAIPAEGLVSILKKRNDAVGGHPAQMQQKPSKRRVRFQEIDDNLDQDEVGGGSCVLLILLCIATVFLSVGGTALYCTLGDMESPVCTDFADNVDFYYTKLLQGVAGLKHWVYLS", "length": 703 }, "evidence": [ { "id": "E1BC04", "url": "https://omabrowser.org/oma/group/E1BC04/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H7N5-1", "protein_name": "Consortin", "gene_name": "Cnst", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDDREAPTYRLQIEPQDGCHPGESVERRVTPLPSVSDENENQLDGDRPAGLTGSDSAMGRATVFEQDSLNNNESCLPPCEVAPSETAEQTPCEGPKDDQPSSGQDKKPPGKRSPRAKKGTPKKVPPGDATPLMQTSNAELQAAGEEAAGVNANDPPKAPVPELQPLFSLIRGEVEQMDSRALPLFLHQVAETYFQEEDYEKAMKFIQLERLYHEQLLANLSAIQEQWETKWKAVQPHTVPPLRNSEKGFNGEDFEQLAKICTTHQDPLLAKHKIAPVEKSLGRKCFSRVTVSEEPKERGATAKEPETETCPGMEPSRGQHEEQPQESSPSSHQMDWQAASPSLPVTAGKEPLFSTNANTQSPETARSRSGPDAAESACEDDSCLQEPPTEDHPGVAEDPKGSPPSESVTEPQLSPSGDSIPPVLISEGKYSETHRKELCLPVQGVLEALPRDQPQSSELDESQQPHLPATDGKSPHSQTDLEPGSENALCGDSKASDVRTLCPEVCMAPEEGRDKEDEVSKETEDYLNSLLEGCLKDAEESLSYEDIQDEDSDLLQDLSPEEASYSLQESLPPDESSLSLDDLAKKIEIAEAVPAEGLVSILKKRNDTIGDHPAQMQQKPAKRRVRFQEIDDSLDQDEVGSGSCILLILLCVATVFLSVGGTALYCTVGDMQSPVCTDFADNVDFYYTKLLQGVAGLKHWVYLS", "length": 704 }, "evidence": [ { "id": "E1BC04", "url": "https://omabrowser.org/oma/group/E1BC04/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6PJW8-1", "protein_name": "Consortin", "gene_name": "CNST", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDDSDTPTYYLQIEPQDGCHPGDSVERSVTCLPSASDENENQLDGDGHEHLTSSDSAMGKPQVSEQDSLNNNESCTLSCEVAAGENLQNTLCEASRDEQAFLGKDKKIPGKRSPRSKKGTAKKIPPGLFSGDIAPLMQEKVLSAVTYAVDDEEAAEVNANEQPEAPKLVLQSLFSLIRGEVEQLDSRALPLCLHQIAESYFQEEDYEKAMKFIQLERLYHEQLLANLSAIQEQWETKWKTVQPHTVTALRNSEKGFNGEDFERLTKICATHQDPLLSKHKIAAVEKSQERKCSTQLLVSEDPKEGGATTKESESKTCLGTESSKESQHTVEPLGSSPCCHQMDVQTDSPSLSVTAGKDHMEELLCSAEATLALHTQSSETAGSPSGPDSSEDACEDDSRLQLAQTEACQDVARIEGIAEDPKVFLSSKSKTEPLISPGCDRIPPALISEGKYSQAQRKELRLPLRDASEALPTDQLENNELNELQQPDLTDSDGKSPQAQADSDGSENVLCGNNQISDLGILLPEVCMAPEEKGDKDDQLNKETEDYLNSLLEGCLKDTEDSLSYEDNQDDDSDLLQDLSPEEASYSLQENLPSDESCLSLDDLAKRIEIAEVVPTEGLVSILKKRNDTVGDHPAQMQHKPSKRRVRFQEIDDSLDQDEVGGGSCILLVLLCIATVFLSVGGTALYCTFGDMESPVCTDFADNMDFYYTKLLQGVAELKHWIYLS", "length": 725 }, "evidence": [ { "id": "E1BC04", "url": "https://omabrowser.org/oma/group/E1BC04/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8CBC4-1", "protein_name": "Consortin", "gene_name": "Cnst", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDDSDPPTYSLQIEPQDGCHPGDSVERRVTRLPSVSDENENQLAGDGPAGLTTSEGAMGRATVSEQDSLNNNESFPSSCEAAPTENAENTPSEGPKDDPPSLGQDQKLPAKRSPRAKKSSPKSAPPGDAVPVMQTQNATSQAAGEEEAAGVNANDPPKAPALQPLFSLIRGEVAQMDSRALPLFLHQVAETYFQEEDYEKAMKFIQLERLYHEQLLANLSAIQEQWETKWKAVQPRTVTPLRNSEKGFNGEDFEQLAKICTTHQDPLLSKLKTAPVEPSPERKSLARAIMSEEAVGTEAAAKEPEIETCPSTDPSGDRHEEEPQESSPGCHQMEWQTASPELPGTAGKDHTEELPSSTNATLDLHTQSLETAGSRSGPAAASNACKDSSCVPAPPTEDHCGVARDPKVAPPSESVAEQKLSTGDDGALPGLISEGKYSQAHRKELCLPLQDAFEALPRDQPHSSEVAEPRQPDVTASDGKSAQSQAGLETGPESALCGDRKACDVSTLCLEVCMAPEERRDSEDRVSKETEDYLHSLLERCLKDAEDSLSYEDIQDDDSDLLQDLSPEEASYSLQEDLPPDESTLSLDDLAKKIEIAEAIPAEGLVSILKKRNDTVGSHPAQMQQKPAKRRVRFQEIDDNLEQDEVGGGSCILLILLCIATVFLSVGGTALYCTLGNIESPVCTDFADNVDFYYTKLLQGVAGLKHWVYLS", "length": 711 }, "evidence": [ { "id": "E1BC04", "url": "https://omabrowser.org/oma/group/E1BC04/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "connexin binding", "id": "GO:0071253", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071253", "evidence": [ { "database": "UniProtKB", "id": "E1BC04", "url": "https://www.uniprot.org/uniprotkb/E1BC04" } ], "pmid": "" }, { "name": "phosphatase binding", "id": "GO:0019902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019902", "evidence": [ { "database": "UniProtKB", "id": "E1BC04", "url": "https://www.uniprot.org/uniprotkb/E1BC04" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "E1BC04", "url": "https://www.uniprot.org/uniprotkb/E1BC04" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BC04", "url": "https://www.uniprot.org/uniprotkb/E1BC04" } ], "pmid": "" }, { "name": "transport vesicle", "id": "GO:0030133", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030133", "evidence": [ { "database": "UniProtKB", "id": "E1BC04", "url": "https://www.uniprot.org/uniprotkb/E1BC04" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "E1BC04", "url": "https://www.uniprot.org/uniprotkb/E1BC04" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of Golgi to plasma membrane protein transport", "id": "GO:0042998", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042998", "evidence": [ { "database": "UniProtKB", "id": "E1BC04", "url": "https://www.uniprot.org/uniprotkb/E1BC04" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 226, "end_pos": 228, "annotation": "n_glycosylation_sequon" }, { "start_pos": 623, "end_pos": 625, "annotation": "n_glycosylation_sequon" }, { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BC04-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 721, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BC04-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BC04" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BC04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC04" }, { "id": "PF15281", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15281" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Consortin C-terminal", "eco_id": "ECO_0000259", "start_pos": 608, "end_pos": 718, "start_aa": "Glu", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BC04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC04" }, { "id": "PF22883", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22883" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Consortin N-terminal", "eco_id": "ECO_0000259", "start_pos": 185, "end_pos": 236, "start_aa": "Asp", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 226, "end_pos": 228 }, { "start_pos": 623, "end_pos": 625 }, { "start_pos": 72, "end_pos": 74 }, { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B844-1", "uniprot_ac": "E1B844", "uniprot_id": "E1B844_BOVIN", "mass": { "chemical_mass": 52004.0, "monoisotopic_mass": 52004.0 }, "refseq": {}, "gene_names": [ { "name": "CTXN1", "type": "recommended", "evidence": [ { "id": "E1B844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B844" } ] }, { "name": "TIMM44", "type": "recommended", "evidence": [ { "id": "E1B844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B844" } ] }, { "name": "CTXN1", "type": "synonym", "evidence": [ { "id": "E1B844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B844" } ] } ], "protein_names": [ { "name": "Mitochondrial import inner membrane translocase subunit TIM44", "type": "recommended", "evidence": [ { "id": "E1B844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B844/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.", "evidence": [ { "database": "UniProtKB", "id": "E1B844", "url": "https://www.uniprot.org/uniprotkb/E1B844#function" }, { "database": "UniProtKB", "id": "ARBA00057148", "url": "https://www.uniprot.org/uniprotkb/ARBA00057148#function" }, { "database": "UniProtKB", "id": "A0AAA9RY35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY35#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B844", "url": "https://www.uniprot.org/uniprotkb/E1B844" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TIMM44", "url": "https://www.uniprot.org/uniprotkb/E1B844", "locus": { "chromosome": "7", "start_pos": 16680591, "end_pos": 16695710, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015567", "url": "https://www.ensembl.org/id/ENSBTAG00000015567" } ] } } ], "crossref": [ { "id": "E1B844", "url": "https://alphafold.ebi.ac.uk/entry/E1B844", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR007379", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007379", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017303", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017303", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039544", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039544", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NFQMEPF", "url": "https://omabrowser.org/oma/group/NFQMEPF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B844", "url": "https://www.orthodb.org/?gene=E1B844", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10721", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10721", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10721:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10721:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04280", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04280", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RY35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RY35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY35-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B844", "url": "https://www.uniprot.org/uniprotkb/E1B844", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B844-1", "url": "https://www.uniprot.org/uniprotkb/E1B844-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAALRAGWCRCPRRCVGSGVHLLSSHNLVPLPHGSYQLPRPSGELTLSKSYSSGSRKGFLSGLLDNIKQELAKNKEMKESIKKFRDEAKKLEESDALQEARRKYRTIESETLRTSEVIKKKLGEITGTVKESLDEVSKSDLGRKIKEGVEEAAKTAKQSAESVSKGGERLGRTAAFKALSQGVESVKKEIDESVLGQTGPYRRPERLRKRKEFAGEKFKEEKVFEANEEALGVVLHKDSKWYQQWKDFRDNNVVFNRFFEMKMKYDESDNAFIRASRVLTDKVTDLLGGLFSKTEMSEVLTEILRVDPAFDKDRFLQQCENDIIPNVLEAMISGELDILKDWCYEATYSQLAHPIQQAKALGLQFHSRILDIDHIDLAMGKMMEQGPVLIITFQAQMVMVIKNPKGEVVEGDPDKVLRMLYVWALCRDQDELNPYAAWRLLDISASSTEQGARRCEP", "length": 459, "header": "tr|E1B844-1|E1B844_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit TIM44 OS=Bos taurus OX=9913 GN=TIMM44 PE=3 SV=2 CANONICAL=E1B844-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RY35-1", "url": "https://www.uniprot.org/uniprotkb/E1B844/entry#A0AAA9RY35-1", "sequence": { "sequence": "MAAAALRAGWCRCPRRCVGSGVHLLSSHNLVPLPHGSYQLPRPSGELTLSKSYSSGSRKGFLSGLLDNIKQELAKNKEMKESIKKFRDEAKKLEESDALQEARRKYRTIESETLRTSEVIKKKLGEITGTVKESLDEVSKSDLGRKIKEGVEEAAKTAKQSAESVSKGGERLGRTAAFKALSQGVESVKKEIDESVLGQTGPYRRPERLRKRKEFAGEKFKEEKVFEANEEALGVVLHKDSKWYQQWKDFRDNNVVFNRFFEMKMKYDESDNAFIRASRVLTDKVTDLLGGLFSKTEMSEVLTEILRVDPAFDKDRFLQQCENDIIPNVLEAMISGELDILKDWCYEATYSQLAHPIQQAKALGLQFHSRILDIDHIDLAMGKMMEQGPVLIITFQAQMVMVIKNPKGEVVEGDPGARRCEP", "length": 422, "header": "tr|A0AAA9RY35-1|E1B844_BOVIN Computationally mapped isoform of Mitochondrial import inner membrane translocase subunit TIM44 OS=Bos taurus OX=9913 GN=TIMM44 PE=3 SV=1 CANONICAL=E1B844-1" }, "locus": { "chromosome": "7", "start_pos": 16695627, "end_pos": 16681601, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115136.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115136.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076147.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076147.1" } ] } }, { "isoform_ac": "E1B844-1", "url": "https://www.uniprot.org/uniprotkb/E1B844/entry#E1B844-1", "sequence": { "sequence": "MAAAALRAGWCRCPRRCVGSGVHLLSSHNLVPLPHGSYQLPRPSGELTLSKSYSSGSRKGFLSGLLDNIKQELAKNKEMKESIKKFRDEAKKLEESDALQEARRKYRTIESETLRTSEVIKKKLGEITGTVKESLDEVSKSDLGRKIKEGVEEAAKTAKQSAESVSKGGERLGRTAAFKALSQGVESVKKEIDESVLGQTGPYRRPERLRKRKEFAGEKFKEEKVFEANEEALGVVLHKDSKWYQQWKDFRDNNVVFNRFFEMKMKYDESDNAFIRASRVLTDKVTDLLGGLFSKTEMSEVLTEILRVDPAFDKDRFLQQCENDIIPNVLEAMISGELDILKDWCYEATYSQLAHPIQQAKALGLQFHSRILDIDHIDLAMGKMMEQGPVLIITFQAQMVMVIKNPKGEVVEGDPDKVLRMLYVWALCRDQDELNPYAAWRLLDISASSTEQGARRCEP", "length": 459, "header": "tr|E1B844-1|E1B844_BOVIN Isoform 1 of Mitochondrial import inner membrane translocase subunit TIM44 OS=Bos taurus OX=9913 GN=TIMM44 PE=3 SV=2 CANONICAL=E1B844-1" }, "locus": { "chromosome": "7", "start_pos": 16695627, "end_pos": 16681601, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020681.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020681.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020681.6", "url": "https://www.ensembl.org/id/ENSBTAP00000020681.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A480JTC0-1", "protein_name": "Mitochondrial import inner membrane translocase subunit TIM44", "gene_name": "TIMM44", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAAALRGGWCRCPRRCFSSGVHFLSRHNLVPLPLGTYQMPWPSGQQTLSRSYSSGNRKGFLSGLLDNIKQELAKNKEMKESIKKFRDEARKLEESDALQEARRKYRTIESETMRTGEVIRKKLGEITGTVKESLDEVSKSDLGRKIKEGVEEAAKTAKQSAESVSKGGEKLGRTAAFKALSQGVESVKKEIDESVLGQTGPYRRPERLRKRKEFAGEKFKEEKVFEANEEALGVVLHKDSKWYQQWKDFRDNNVVFNRFFEMKMKYDESDNALIRASRVLTDKVTDLLGGLFSKTEMSEVLTEILRVDPAFDKERFLQQCENDIIPNVLEAMISGELDILKDWCYEATYSQLAHPIQQAKALGLQFHSRILDIDNIDLAMGKMMEQGPVLIITFQAQLVMVIKNPKGEVVEGDPDKVLRMLYVWALCRDQDELNPYAAWRLLDISASSTEQVL", "length": 454 }, "evidence": [ { "id": "E1B844", "url": "https://omabrowser.org/oma/group/E1B844/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1NU71-1", "protein_name": "Mitochondrial import inner membrane translocase subunit TIM44", "gene_name": "TIMM44", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAAAASSCRKCLISGMWLMPRRYPVPAVHGGAVYRASRPVSEINQSRCYSSGGRKGFISGFVENIKQELAKNKEMKESIKKFRDEAKKLEESDALREARRKYKTIESETVKTSEVIKKKLEEITGTVKESLDEVSKSDIGRKIKEGVEEAAKTAKQSAESVTKGGEKLGKTAAFKAISQGVETVKKEIDESVLGQTGPYKRPERLRKRTEFSGERIKEERIFEANEEAMGMVLHKDSRWYQQWKDFKDNNVVFNRFFEMKMKYDESDNAFIRASRAVTDKVTDLIGGLFSKTEMSEVLTEILKVDPSFDKDRFLKQCERDIIPNVLEAMISGELDILKDWCYEATYSQLAHPIQQAKAMGLQFHSRILDIDNIDLAMGKMMEQGPVLIITFQAQIVMVIKNQKGEVVEGDPDKVLRMLYVWALCRDQDELNPYAAWRLLDISSSSSEQVL", "length": 451 }, "evidence": [ { "id": "E1B844", "url": "https://omabrowser.org/oma/group/E1B844/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O35094-1", "protein_name": "Mitochondrial import inner membrane translocase subunit TIM44", "gene_name": "Timm44", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAALRGGWCRCPRRCLGSGIQFLSSHNLPRGGSSYQISRPGGELTLTKSYSSGSRKGFLSGLLDNIKQELAQNKEMKESIKKFRDEAKKLEESDALQEARRKYKTIESETVRTSEAIKKKLGELTGTVKESLDEVSKSDLGRKIKEGVEEAARTAKQSAESVSKGGEKLGKTAAFKAISQGVESVKKEIDESVLGHTGTYRRPERLRKRTEFAGAKFKESKVFEANEEALGVVLHKDSKWYQQWKDFKDNNVVFNRFFEMKMKYDESDNVLIRASRALTDKVTDLLGGLFSKTEMSEVLTEILRVDPTFDKDRFLHQCETDIIPNILEAMISGELDILKDWCYEATYNQLAHSIQQAKALGLQFHSRILDISNVDLAMGKMMEQGPVLIVTFQAQLVMVIKNPKGEVFDGDPDKVLRMLYVWALCRDQEELNPYAAWRLLDISASSTEQIL", "length": 453 }, "evidence": [ { "id": "E1B844", "url": "https://omabrowser.org/oma/group/E1B844/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O35857-1", "protein_name": "Mitochondrial import inner membrane translocase subunit TIM44", "gene_name": "Timm44", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAALRGGWCRCPRRCLGSGIQFLSSHNLPHGSSYQISRPGRELTLTKSYSSGSRKGFLSGLLDNIKQELAKNKEMKESIKKFRDEAKKLEESDALQEARRKYKSIESETVRTSEAIKKKLGELTGTVKESLDEVSKSDLGRKIKEGVEEAARTAKQSAESVSKSGEKLGKTAAFKAISQGVESVKKELDESVLGQTGPYRRPERLRKRTEFAGAKFKESKVFEANEEALGVVLHKDSKWYQQWKDFKDNNVVFNRFFEMKMKYDESDNVLIRASRALTDKVTDLLGGLFSKTEMSEVLTEILRVDPTFDKDHFLHQCETDIIPNILEAMISGELDILKDWCYEATYSQLAHPIQQAKALGFQFHSRILDISNVDLAMGKMMEQGPVLIVTFQAQVVMVIKNSKGEVYDGDPDKVQRMLYVWALCRDQEELNPYAAWRLLDISASSTEQIL", "length": 452 }, "evidence": [ { "id": "E1B844", "url": "https://omabrowser.org/oma/group/E1B844/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O43615-1", "protein_name": "Mitochondrial import inner membrane translocase subunit TIM44", "gene_name": "TIMM44", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAALRSGWCRCPRRCLGSGIQFLSSHNLPHGSTYQMRRPGGELPLSKSYSSGNRKGFLSGLLDNVKQELAKNKEMKESIKKFRDEARRLEESDVLQEARRKYKTIESETVRTSEVLRKKLGELTGTVKESLHEVSKSDLGRKIKEGVEEAAKTAKQSAESVSKGGEKLGRTAAFRALSQGVESVKKEIDDSVLGQTGPYRRPQRLRKRTEFAGDKFKEEKVFEPNEEALGVVLHKDSKWYQQWKDFKENNVVFNRFFEMKMKYDESDNAFIRASRALTDKVTDLLGGLFSKTEMSEVLTEILRVDPAFDKDRFLKQCENDIIPNVLEAMISGELDILKDWCYEATYSQLAHPIQQAKALGLQFHSRILDIDNVDLAMGKMMEQGPVLIITFQAQLVMVVRNPKGEVVEGDPDKVLRMLYVWALCRDQDELNPYAAWRLLDISASSTEQIL", "length": 452 }, "evidence": [ { "id": "E1B844", "url": "https://omabrowser.org/oma/group/E1B844/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q01852-1", "protein_name": "Mitochondrial import inner membrane translocase subunit TIM44", "gene_name": "TIM44", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MHRSTFIRTSGTSSRTLTARYRSQYTGLLVARVLFSTSTTRAQGGNPRSPLQIFRDTFKKEWEKSQELQENIKTLQDASGKLGESEAYKKAREAYLKAQRGSTIVGKTLKKTGETMEHIATKAWESELGKNTRKAAAATAKKLDESFEPVRQTKIYKEVSEVIDDGESSRYGGFITKEQRRLKRERDLASGKRHRAVKSNEDAGTAVVATNIESKESFGKKVEDFKEKTVVGRSIQSLKNKLWDESENPLIVVMRKITNKVGGFFAETESSRVYSQFKLMDPTFSNESFTRHLREYIVPEILEAYVKGDVKVLKKWFSEAPFNVYAAQQKIFKEQDVYADGRILDIRGVEIVSAKLLAPQDIPVLVVGCRAQEINLYRKKKTGEIAAGDEANILMSSYAMVFTRDPEQIDDDETEGWKILEFVRGGSRQFT", "length": 431 }, "evidence": [ { "id": "E1B844", "url": "https://omabrowser.org/oma/group/E1B844/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q9VDZ7-1", "protein_name": "Mitochondrial import inner membrane translocase subunit TIM44", "gene_name": "CG117799", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MKATSCRPIPFINFRIVRYFYRPRRLNKYYDIYRIAALVRDRACLFTCQQASQNLQQQQPRFYSAPGRRAGFFSQFFDNMKAEMDKNKEIKDNIRKFREEAQKLEESDALKSARQKFNIVESEAQKSSSMLKEQLGAIKERVGDVLEDASKSHLAKKVTEELSKKARGVSDTISDTSGKLGQTSAFQAISNTTTTIKKEMDSASIENRVYRAPAKLRKRVQLVMSDSDRVVEPNTEATGMELHKDSKFYESWENFKNNNTYVNKVLDWKVKYDESENPVIRASRLLTDKVSDVMGGLFSKTELSETMTELVKIDPSFDQKDFLRDCETDIIPNILESIVRGDLEILKDWCFESTFNIIANPIKEAKKAGVYLDSKILDIENIELAMGKVMEQGPVLIITFQAQQIMCVRDQKSQVVEGDPEKVMRVHYVWVLCRDRNELNPKAAWRLMELSANSSEQFV", "length": 459 }, "evidence": [ { "id": "E1B844", "url": "https://omabrowser.org/oma/group/E1B844/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1B844", "url": "https://www.uniprot.org/uniprotkb/E1B844" } ], "pmid": "" }, { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "E1B844", "url": "https://www.uniprot.org/uniprotkb/E1B844" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "E1B844", "url": "https://www.uniprot.org/uniprotkb/E1B844" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "E1B844", "url": "https://www.uniprot.org/uniprotkb/E1B844" } ], "pmid": "" }, { "name": "TIM23 mitochondrial import inner membrane translocase complex", "id": "GO:0005744", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005744", "evidence": [ { "database": "UniProtKB", "id": "E1B844", "url": "https://www.uniprot.org/uniprotkb/E1B844" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein import into mitochondrial matrix", "id": "GO:0030150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030150", "evidence": [ { "database": "UniProtKB", "id": "E1B844", "url": "https://www.uniprot.org/uniprotkb/E1B844" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B844-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 459, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B844-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B844" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B844" }, { "id": "SM00978", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00978" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tim44-like", "eco_id": "ECO_0000259", "start_pos": 298, "end_pos": 447, "start_aa": "Met", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A7YWC8-1", "uniprot_ac": "A7YWC8", "uniprot_id": "VMAC_BOVIN", "mass": { "chemical_mass": 17813.0, "monoisotopic_mass": 17813.0 }, "refseq": { "ac": "NP_001098841", "name": "vimentin-type intermediate filament-associated coiled-coil protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098841" }, "gene_names": [ { "name": "VMAC", "type": "recommended", "evidence": [ { "id": "A7YWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWC8" } ] }, { "name": "VMAC", "type": "synonym", "evidence": [ { "id": "NP_001098841", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098841" } ] } ], "protein_names": [ { "name": "Vimentin-type intermediate filament-associated coiled-coil protein", "type": "recommended", "evidence": [ { "id": "A7YWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWC8/entry#names_and_taxonomy" } ] }, { "name": "vimentin-type IF-associated coiled-coil protein", "type": "synonym", "evidence": [ { "id": "NP_001098841", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098841" } ] }, { "name": "vimentin-type intermediate filament-associated coiled-coil protein", "type": "synonym", "evidence": [ { "id": "NP_001098841", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098841" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7YWC8", "url": "https://www.uniprot.org/uniprotkb/A7YWC8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VMAC", "url": "https://www.uniprot.org/uniprotkb/A7YWC8", "locus": { "chromosome": "7", "start_pos": 18468629, "end_pos": 18472439, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006067", "url": "https://www.ensembl.org/id/ENSBTAG00000006067" } ] } } ], "crossref": [ { "id": "A7YWC8", "url": "https://alphafold.ebi.ac.uk/entry/A7YWC8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006067", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006067", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515212", "url": "https://www.ncbi.nlm.nih.gov/gene/515212", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "bta:515212", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515212", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ERTVHGQ", "url": "https://omabrowser.org/oma/group/ERTVHGQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A7YWC8", "url": "https://www.orthodb.org/?gene=A7YWC8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "NP_001098841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098841", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RY36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RY36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY36-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7YWC8", "url": "https://www.uniprot.org/uniprotkb/A7YWC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7YWC8-1", "url": "https://www.uniprot.org/uniprotkb/A7YWC8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAPPPLQIREANAHLAAVHRRAAELEARLEAAECMVRAQAERLARHDQQLSAALDELGRAKDREIAALREQLLTSEAAVQSLQAAVRQRDKLIGQLQPRAELLQDLCRRRPPLAGLLATLAEAERLGPLPASDLLPGGPSSPLANSTGEEEGSDQLEPAVFGTTV", "length": 166, "header": "sp|A7YWC8-1|VMAC_BOVIN Isoform 1 of Vimentin-type intermediate filament-associated coiled-coil protein OS=Bos taurus OX=9913 GN=VMAC PE=2 SV=1 CANONICAL=A7YWC8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RY36-1", "url": "https://www.uniprot.org/uniprotkb/A7YWC8/entry#A0AAA9RY36-1", "sequence": { "sequence": "MSAPPPLQIREANAHLAAVHRRAAELEARLEAAECMVRAQAERLARHDQQLSAALDELGRAKDREIAALREQLLTSEAAVQSLQAAVRQRDKLIGQLQPRAELLQDLCRRRPPLAGLLATLAEAERLGPLPASDLLPGGPSSPLANSTGEEEGSDQLEPAVFGTTVKKPLTFLILMKAHNGAIFCAYTENVGLQRVTRTSAAGCHC", "length": 206, "header": "tr|A0AAA9RY36-1|VMAC_BOVIN Computationally mapped isoform of Vimentin-type intermediate filament-associated coiled-coil protein OS=Bos taurus OX=9913 GN=VMAC PE=2 SV=1 CANONICAL=A7YWC8-1" }, "locus": { "chromosome": "7", "start_pos": 18472423, "end_pos": 18468630, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121175.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121175.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078459.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078459.1" } ] } }, { "isoform_ac": "A7YWC8-1", "url": "https://www.uniprot.org/uniprotkb/A7YWC8/entry#A7YWC8-1", "sequence": { "sequence": "MSAPPPLQIREANAHLAAVHRRAAELEARLEAAECMVRAQAERLARHDQQLSAALDELGRAKDREIAALREQLLTSEAAVQSLQAAVRQRDKLIGQLQPRAELLQDLCRRRPPLAGLLATLAEAERLGPLPASDLLPGGPSSPLANSTGEEEGSDQLEPAVFGTTV", "length": 166, "header": "sp|A7YWC8-1|VMAC_BOVIN Isoform 1 of Vimentin-type intermediate filament-associated coiled-coil protein OS=Bos taurus OX=9913 GN=VMAC PE=2 SV=1 CANONICAL=A7YWC8-1" }, "locus": { "chromosome": "7", "start_pos": 18472423, "end_pos": 18470726, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007971.4", "url": "https://www.ensembl.org/id/ENSBTAT00000007971.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007971.3", "url": "https://www.ensembl.org/id/ENSBTAP00000007971.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515212", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515212", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A2R8QC89-1", "protein_name": "Vimentin-type intermediate filament-associated coiled-coil protein", "gene_name": "vmac", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSSPSPVQIREANAHLAALHRRVSELEQRLREAERTVREQAESLIRKDEQLRAATQEITEAKDKEIFFLHEKLCQSEESIHKLNQTIKEKDSLIGQLQHRCQLLDNICKSRPLLDSMLAQMAEAERMGPVSDLGKPTTNSSLTDGESNCSPSRLSNHKDFSLSEDDSDDQELDGVVFGTTV", "length": 181 }, "evidence": [ { "id": "A7YWC8", "url": "https://omabrowser.org/oma/group/A7YWC8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A5G2QMQ1-1", "protein_name": "Vimentin type intermediate filament associated coiled-coil protein", "gene_name": "VMAC", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSAPPPLQIREANAHLAAVHRRAAELEARLDAAERTVRAQAERLARHDQQLRAALDELGRAKDREIATLQEQLLTSEAAVQSLQAAVRQRDELIRQLLPRAELLQDICRRRPLLAGLLATLVEAERLGPLPASDPSHVLPGGPSSPLANSTGEEEDRDHRQPALFGTTV", "length": 169 }, "evidence": [ { "id": "A7YWC8", "url": "https://omabrowser.org/oma/group/A7YWC8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q2NL98-1", "protein_name": "Vimentin-type intermediate filament-associated coiled-coil protein", "gene_name": "VMAC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSAPPALQIREANAHLAAVHRRAAELEARLDAAERTVHAQAERLALHDQQLRAALDELGRAKDREIATLQEQLMTSEATVHSLQATVHQRDELIRQLQPRAELLQDICRRRPPLAGLLDALAEAERLGPLPASDPGHPPPGGPGPPLDNSTGEEADRDHLQPAVFGTTV", "length": 169 }, "evidence": [ { "id": "A7YWC8", "url": "https://omabrowser.org/oma/group/A7YWC8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BP01-1", "protein_name": "Vimentin-type intermediate filament-associated coiled-coil protein", "gene_name": "Vmac", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAPPPLQIREANAHLAAVHRRAAELERRLLAAERTIGAQAERLACHDQHLRAALDELGRAKDREISALQEQLLSSEATVRSLQAAVDQRDQMIQQLQPRADLLQDITRHRPPLAALLATLEEAEELGPLPASHSHRAQLLPDGPGPPLGNNMGKEEGQDDQDDQQPAVFGTTV", "length": 174 }, "evidence": [ { "id": "A7YWC8", "url": "https://omabrowser.org/oma/group/A7YWC8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A7YWC8", "url": "https://www.uniprot.org/uniprotkb/A7YWC8" } ], "pmid": "" }, { "name": "type III intermediate filament", "id": "GO:0045098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045098", "evidence": [ { "database": "UniProtKB", "id": "A7YWC8", "url": "https://www.uniprot.org/uniprotkb/A7YWC8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7YWC8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 166, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7YWC8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7YWC8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 146, "end_pos": 148 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B8U4-1", "uniprot_ac": "E1B8U4", "uniprot_id": "E1B8U4_BOVIN", "mass": { "chemical_mass": 62222.0, "monoisotopic_mass": 62222.0 }, "refseq": { "ac": "NP_001192829", "name": "membrane frizzled-related protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192829" }, "gene_names": [ { "name": "MFRP", "type": "recommended", "evidence": [ { "id": "E1B8U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8U4" } ] }, { "name": "MFRP", "type": "synonym", "evidence": [ { "id": "NP_001192829", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192829" } ] } ], "protein_names": [ { "name": "Membrane frizzled-related protein", "type": "synonym", "evidence": [ { "id": "E1B8U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8U4/entry#names_and_taxonomy" } ] }, { "name": "membrane frizzled-related protein", "type": "synonym", "evidence": [ { "id": "NP_001192829", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192829" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8U4", "url": "https://www.uniprot.org/uniprotkb/E1B8U4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MFRP", "url": "https://www.uniprot.org/uniprotkb/E1B8U4", "locus": { "chromosome": "15", "start_pos": 29922657, "end_pos": 29928236, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009748", "url": "https://www.ensembl.org/id/ENSBTAG00000009748" } ] } } ], "crossref": [ { "id": "E1B8U4", "url": "https://alphafold.ebi.ac.uk/entry/E1B8U4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009748", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009748", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00041", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00041", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00112", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00112", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07066", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07066", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "522979", "url": "https://www.ncbi.nlm.nih.gov/gene/522979", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020067", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020067", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023415", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023415", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522979", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522979", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WMCDLWR", "url": "https://omabrowser.org/oma/group/WMCDLWR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8U4", "url": "https://www.orthodb.org/?gene=E1B8U4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24251", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24251", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24251:SF30", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24251:SF30", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00057", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00057", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00431", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00431", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01392", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01392", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192829", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RZT4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZT4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZT4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8U4", "url": "https://www.uniprot.org/uniprotkb/E1B8U4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8U4-1", "url": "https://www.uniprot.org/uniprotkb/E1B8U4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKDCSDIVLCVETTELSKTEFCNPAFEPESGPPCPFPALREDADCSAPAPWHGRHPRRLQPDCRFSWLCVLLLAGLLLLLLGLLVAIILAQLQATTSPGATYHPLPSRGLATTGTTPATSTTTSQATGTPKGQPEAGVSLAPQSACGGLLPGPRGFFSSPNYPDPYPPNAHCVWHIQVATDHTIQLKIETLSTESVASCLFDRLEISPEPEGPLLRVCGRVPPPTLNTNASRLRVAFVSDSSVEGSGFHAWYQAVAPGHGSCAHEEFPCDQFVCLLRDSVCDGFANCADGSDEINCSAKFSGCGGNLTGLEGTFSAPSYLQQYPHQQLCTWHISVPAGHGIELLFHNFSLEAQDECKSDYVEVYEAHSSGALSLLDRFCGAEPPPRLISSRHQLAVLFRTDHGFSAGGFSATYRALNATESPCRPGELSCQDGGCKSPQWMCSTWRDCADDNCSSPLFPPPELACEPVQVEMCIGLSYNTTAFPNIWVGMTTQEEVVEVLRGYKSLTSLPCYQNFRRLLCGLLVPHCTPLGSVLPPCRSVCQEAERQCQSGLALLGTPWPFNCNRLPEAAGLEACAQP", "length": 578, "header": "tr|E1B8U4-1|E1B8U4_BOVIN Isoform 1 of Membrane frizzled-related protein OS=Bos taurus OX=9913 GN=MFRP PE=4 SV=2 CANONICAL=E1B8U4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZT4-1", "url": "https://www.uniprot.org/uniprotkb/E1B8U4/entry#A0AAA9RZT4-1", "sequence": { "sequence": "MKDCSDIVLCVETTELSKTEFCNPAFEPESGPPCPFPALREDADCSAPAPWHGRHPRRLQPDCRFSWLCVLLLAGLLLLLLGLLVAIILAQLQATTSPGATYHPLPSRGLATTGTTPATSTTTSQATGTPKGQPEAGVSLAPQSACGGLLPGPRGFFSSPNYPDPYPPNAHCVWHIQVATDHTIQLKIETLSTESVASCLFDRLEISPEPEGPLLRVCGRVPPPTLNTNASRLRVAFVSDSSVEGSGFHAWYQAVAPGHGSCAHEEFPCDQFVCLLRDSVCDGFANCADGSDEINCSAKFSGSVEQSRPHVSSPRATSWQCSLGQTMASALGASQPPTGPSTPQRAPVGPESCPARMEGVRVHNGCAAHGETAPMTTAAAPCSHPQSLTSLPCYQNFRRLLCGLLVPHCTPLGSVLPPCRSVCQEAERQCQSGLALLGTPWPFNCNRLPEAAGLEACAQP", "length": 460, "header": "tr|A0AAA9RZT4-1|E1B8U4_BOVIN Computationally mapped isoform of Membrane frizzled-related protein OS=Bos taurus OX=9913 GN=MFRP PE=4 SV=1 CANONICAL=E1B8U4-1" }, "locus": { "chromosome": "15", "start_pos": 29927990, "end_pos": 29923118, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093691.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093691.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075325.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075325.1" } ] } }, { "isoform_ac": "E1B8U4-1", "url": "https://www.uniprot.org/uniprotkb/E1B8U4/entry#E1B8U4-1", "sequence": { "sequence": "MKDCSDIVLCVETTELSKTEFCNPAFEPESGPPCPFPALREDADCSAPAPWHGRHPRRLQPDCRFSWLCVLLLAGLLLLLLGLLVAIILAQLQATTSPGATYHPLPSRGLATTGTTPATSTTTSQATGTPKGQPEAGVSLAPQSACGGLLPGPRGFFSSPNYPDPYPPNAHCVWHIQVATDHTIQLKIETLSTESVASCLFDRLEISPEPEGPLLRVCGRVPPPTLNTNASRLRVAFVSDSSVEGSGFHAWYQAVAPGHGSCAHEEFPCDQFVCLLRDSVCDGFANCADGSDEINCSAKFSGCGGNLTGLEGTFSAPSYLQQYPHQQLCTWHISVPAGHGIELLFHNFSLEAQDECKSDYVEVYEAHSSGALSLLDRFCGAEPPPRLISSRHQLAVLFRTDHGFSAGGFSATYRALNATESPCRPGELSCQDGGCKSPQWMCSTWRDCADDNCSSPLFPPPELACEPVQVEMCIGLSYNTTAFPNIWVGMTTQEEVVEVLRGYKSLTSLPCYQNFRRLLCGLLVPHCTPLGSVLPPCRSVCQEAERQCQSGLALLGTPWPFNCNRLPEAAGLEACAQP", "length": 578, "header": "tr|E1B8U4-1|E1B8U4_BOVIN Isoform 1 of Membrane frizzled-related protein OS=Bos taurus OX=9913 GN=MFRP PE=4 SV=2 CANONICAL=E1B8U4-1" }, "locus": { "chromosome": "15", "start_pos": 29927990, "end_pos": 29923118, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012855.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012855.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012855.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012855.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:522979", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522979", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2ME18-1", "protein_name": "Membrane frizzled-related protein", "gene_name": "Mfrp", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKDYSDVILCPEANELSKTEFCNPAFDPEAGPSCPAPALQKNASSSLKAPWHAQHLRRLQPDCHFSWLCILLLSGLLVLLLGLLVAIILAQFQATSLPRTTQSPLPTRGLAPKGGISSTTPNARTTTTTTSPATTQQQEVAMSPTHQITCGGLLHGPRGFFSSPNYPDLYPPHSHCVWHIQVATGQTIQLKIQALSIEGVPACLFDRLEIAPEPSGSLLRVCGKTPPATLNTNASHLRVSFVSDDDVEGSGFQAWYQAVAPGHWSCAQNEFRCDELLCLKHDLVCDGITNCADGSDEANCSAKNLGCGGNLTGLHGVFSTPNYPQHYPHQQLCTWYISVPMEYGIELQFHNFSLEAQAECKFDYVEVYEASSSRAFSFLGRFCGAKPPAPLISSQHQLAVIFKTDLGISSGGFLATYQAINTSESRCPWAEFSQDGGCWDLQWMCDLWRDCANDSNDNNCSSHLFPQTEPACEPVQVEMCLGLSYNTTAFPNIWVGLGTQSEVVDILRGYKSLTSLPCYQNFRRFLCGLLVPHCTPLGTVLPPCRSVCQEAEQQCQSSLALLGTPWPFNCNRLPEAASLEACSQP", "length": 585 }, "evidence": [ { "id": "E1B8U4", "url": "https://omabrowser.org/oma/group/E1B8U4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZU82-1", "protein_name": "Membrane frizzled-related protein", "gene_name": "Mfrp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKEYADVTLCPEAAELSKTEFCNPAFDLEAGPSCPPPALQKNVSSSLQGPWHVQRLRGLQPDCHFSGLCILLLSGLLLLLLGLLVAVILAQLQATSLPRTTKNPLPTRGGLTPTGVIPSTTPNTTTTTTTTPAITGRQEAAMSPTHQTTCGGLLPGPSGFFSSPNYPDLYPPHSHCVWHIQVATGQTIQLKIQVLSTESMLACLFDRLEISPAPTGPLLRMCGKTPPATVNTNTSHLRVSFVSDNDVEGSGFQAWYQAVAPGHWSCTHYEFHCDLLLCLKQDSVCDGIKDCIDGSDEANCSAKTLGCGGNLTELSGVFSTPNYPQHYPHQQLCTWYIKVPVGYRIRLEFHNFSLEEQTECKFDYVEVYEASNSGTFSSLGRFCGAEPPSHLVSSQHQLTVIFKTDLGISSGGFLATYQAINTTESGCPWADLCGPREFCQSRVRRELQRICDLWKDCANDSNDNCNSHLSPQLDLTCEPVQVEMCLGLSYNTTAFPNIWVGLATQMESLTSLPCYQTFRRFLCGLLEPRCTSLGTILPPCRSVCQEAEQQCQSSLALLGIPWPFNCNRLPVPASLEACSQP", "length": 581 }, "evidence": [ { "id": "E1B8U4", "url": "https://omabrowser.org/oma/group/E1B8U4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SAF7-1", "protein_name": "Membrane frizzled-related protein", "gene_name": "MFRP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKDCSDIILCVETTELSKTEFCNPAFEPESGLPRPPPAFREDPSGRFRAPWHGQRPRGLQPDCRFSWLCVLLLASLLLLLLGLLVAIILAQLQAASPSEAAFHLPPSRGFTTTGAPKGQLEAGMSPTPQSTCGGLLPGPRGFFNSPNYPDPYPPNTYCVWHIQVATDHAIQLKIEALSIEGVASCLFDRLEISPEPEGPLLRVCGRVPPPTLNTNASHLQVAFVSDSSVEGSGFHAWYQAVAPGHGSCAHDEFPCDQLVCLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGMLSAPIYLQQYPHHQLCTWHISVPAGHGIELQFHNFSLDTQDACKFDYVEVYETSNSGALSLLGRFCGAEPPPQRLISSYHQLAVLFRTDHGISGGGFSATYQALNATEKPCGPGELSCRDAGCKSLQWMCGLWRDCAESSGDNCSSPLFPPPELACEPVQVEMCIGLSYNTTAFPNIWVGMATQEEVVELLRGYKSLTSLPCYQNFRRLLCGLLVPHCTPLGSVLPPCRSVCQEAERQCQSGLALLGTPWPFNCNRLPEAAGLESCAQP", "length": 568 }, "evidence": [ { "id": "E1B8U4", "url": "https://omabrowser.org/oma/group/E1B8U4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8K480-1", "protein_name": "Membrane frizzled-related protein", "gene_name": "Mfrp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKDYDDVILRPEASELSKTEFCNPAFDPEAGPSCPPPALQRDVGSRLQAPWHAQRLRGLQPDCHFSWFCILLLSGLLLLLLGLLVAVILAQLQATSLPRTTKNPLLTRGLTPMGVIPSTTPNTTTTTTTTTPARTGQQEAAMSPTHQTTCGGLLPGPSGFFSSPNYPDLYPPLSHCVWHIQVAAGQTIQLKIQALSIESMLTCLFDRLEIISEPTGPLLRVCGKTPPATLNTNTSHLRVSFVSDNDVEGSGFQAWYQAVAPGHWSCAHNEFHCDLLLCLKRDSVCDGITECADGSDEANCSAKTLGCGGNLTGLYGVFSTPNYPQHYPHQQLCTWYIEVPVGYGIRLEFHNFSLEAQAECKFDYVEVYEASNLGTFSFLGRFCGAEPPLNVVSSMHQLAVIFKTDLGISSGGFLATYQAINTTESGCPWAEFCQSGGYRDLQWMCDLWKDCANDSNDNCSSHLSPQPDLTCEPVQVEMCLGLSYNTTAFPNIWVGLATQTEVTDILRGYKSLTSLPCYQTFQRFLCGLLVPRCTSLGTILPPCRSVCQAAEQQCQSSLALLGTPWPFNCNRLPVAASLEACSQP", "length": 584 }, "evidence": [ { "id": "E1B8U4", "url": "https://omabrowser.org/oma/group/E1B8U4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BY79-1", "protein_name": "Membrane frizzled-related protein", "gene_name": "MFRP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKDFSDVILCMEATESSKTEFCNPAFEPESGPPCPPPVFPEDASYSVPAPWHGRRPRGLRPDCRFSWLCVLLLSSLLLLLLGLLVAIILAQLQAAPPSGASHSPLPAGGLTTTTTTPTITTSQAAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDNCSGPLFPPPELACEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLLVPRCTPLGSVLPPCRSVCQEAEHQCQSGLALLGTPWPFNCNRLPEAADLEACAQP", "length": 579 }, "evidence": [ { "id": "E1B8U4", "url": "https://omabrowser.org/oma/group/E1B8U4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B8U4", "url": "https://www.uniprot.org/uniprotkb/E1B8U4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 229, "end_pos": 231, "annotation": "n_glycosylation_sequon" }, { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" }, { "start_pos": 306, "end_pos": 308, "annotation": "n_glycosylation_sequon" }, { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 417, "end_pos": 419, "annotation": "n_glycosylation_sequon" }, { "start_pos": 452, "end_pos": 454, "annotation": "n_glycosylation_sequon" }, { "start_pos": 479, "end_pos": 481, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8U4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 578, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8U4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8U4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8U4" }, { "id": "PS01180", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01180" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CUB", "eco_id": "ECO_0000259", "start_pos": 146, "end_pos": 255, "start_aa": "Cys", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B8U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8U4" }, { "id": "PS50038", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50038" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FZ", "eco_id": "ECO_0000259", "start_pos": 460, "end_pos": 578, "start_aa": "Pro", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 229, "end_pos": 231 }, { "start_pos": 295, "end_pos": 297 }, { "start_pos": 306, "end_pos": 308 }, { "start_pos": 347, "end_pos": 349 }, { "start_pos": 417, "end_pos": 419 }, { "start_pos": 452, "end_pos": 454 }, { "start_pos": 479, "end_pos": 481 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B828-1", "uniprot_ac": "E1B828", "uniprot_id": "E1B828_BOVIN", "mass": { "chemical_mass": 55484.0, "monoisotopic_mass": 55484.0 }, "refseq": { "ac": "NP_001179408", "name": "LEM domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179408" }, "gene_names": [ { "name": "LEMD2", "type": "recommended", "evidence": [ { "id": "E1B828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B828" } ] }, { "name": "LEMD2", "type": "synonym", "evidence": [ { "id": "NP_001179408", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179408" } ] } ], "protein_names": [ { "name": "LEM domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "E1B828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B828/entry#names_and_taxonomy" } ] }, { "name": "LEM domain containing 2", "type": "synonym", "evidence": [ { "id": "NP_001179408", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179408" } ] }, { "name": "LEM domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "NP_001179408", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179408" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B828", "url": "https://www.uniprot.org/uniprotkb/E1B828" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LEMD2", "url": "https://www.uniprot.org/uniprotkb/E1B828", "locus": { "chromosome": "23", "start_pos": 7898387, "end_pos": 7914749, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015538", "url": "https://www.ensembl.org/id/ENSBTAG00000015538" } ] } } ], "crossref": [ { "id": "E1B828", "url": "https://alphafold.ebi.ac.uk/entry/E1B828", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12941", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12941", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "518023", "url": "https://www.ncbi.nlm.nih.gov/gene/518023", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003887", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003887", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011015", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011015", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018996", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018996", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041885", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041885", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052277", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052277", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518023", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518023", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "STSWFCQ", "url": "https://omabrowser.org/oma/group/STSWFCQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B828", "url": "https://www.orthodb.org/?gene=E1B828", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13428", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13428", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13428:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13428:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03020", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03020", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09402", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09402", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179408", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S085", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S085", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S085-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S085-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U055", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U055", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U055-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U055-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B828", "url": "https://www.uniprot.org/uniprotkb/E1B828", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B828-1", "url": "https://www.uniprot.org/uniprotkb/E1B828-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGLSDLELRRELQALGFQPGPITDTTRDVYRNKLRRLRGEARLRGEERPREAARAQGEEARLREEAPLRARPAAASPRAEPWLSPAASGPVYATPGAYGDIGDPAASWSGSRGLARPAPLRRRASARGSSEEDEDGRPFGRTAPGASPGLRRWWAASPASARPPSALLGPDPRPGLRATRAGPAASARARPEAGRRLERCLSRLLLWASLGLLLVFLGILWVKMGKPSAPQEAEDNMKLLPVDCETKTDEFCQAKQKAALLELLHELYNFLAIQAGNFECGNPEKLKSKCIPVMEAQEYIANVTSSSSTKFEAALTWILSSNKDVGIWLKGEDPSELVTTVDKVVCLESSRPRMGVGCRLSRALLTAVTNLLIFFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDTLIPPQSRRRMKRVWDRAVEFLASNESRIQTESHRVAGEDMLVWRWTKPSSFSDSER", "length": 495, "header": "tr|E1B828-1|E1B828_BOVIN Isoform 1 of LEM domain-containing protein 2 OS=Bos taurus OX=9913 GN=LEMD2 PE=4 SV=1 CANONICAL=E1B828-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S085-1", "url": "https://www.uniprot.org/uniprotkb/E1B828/entry#A0AAA9S085-1", "sequence": { "sequence": "MAGLSDLELRRELQALGFQPGPITDTTRDVYRNKLRRLRGEARLRGEERPREAARAQGEEARLREEAPLRARPAAASPRAEPWLSPAASGPVYATPGAYGDIGDPAASWSGSRGLARPAPLRRRASARGSSEEDEDGRPFGRTAPGASPGLRRWWAASPASARPPSALLGPDPRPGLRATRAGPAASARARPEAGRRLERCLSRLLLWASLGLLLVFLGILWVKMGKPSAPQEAEDNMKLLPVDCETKTDEFCQAKQKAALLELLHELYNFLAIQAGNFECGNPEKLKSKCIPVMEAQEYIANVTSSSSTKFEAALTWILSSNKDVGIWLKGEDPSELVTTVDKVVCLESSRPRMGVGCRLSRALLTAVTNLLIFFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDTLIPPQSRSRCEGLGPRSQGQTSQVRTAEQPWGLDLTSPGRKPRDPTLPPESGATSGASLHPRSPLNPLLHTPPNIHCMLGVLGSGLQSDMRLGLTKG", "length": 536, "header": "tr|A0AAA9S085-1|E1B828_BOVIN Computationally mapped isoform of LEM domain-containing protein 2 OS=Bos taurus OX=9913 GN=LEMD2 PE=4 SV=1 CANONICAL=E1B828-1" }, "locus": { "chromosome": "23", "start_pos": 7914716, "end_pos": 7900359, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103340.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103340.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079256.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079256.1" } ] } }, { "isoform_ac": "A0AAA9U055-1", "url": "https://www.uniprot.org/uniprotkb/E1B828/entry#A0AAA9U055-1", "sequence": { "sequence": "MAGLSDLELRRELQALGFQPGPITDTTRDVYRNKLRRLRGEARLRGEERPREAARAQGEEARLREEAPLRARPAAASPRAEPWLSPAASGPVYATPGAYGDIGDPAASWSGSRGLARPAPLRRRASARGSSEEDEDGRPFGRTAPGASPGLRRWWAASPASARPPSALLGPDPRPGLRATRAGPAASARARPEAGRRLERCLSRLLLWASLGLLLVFLGILWVKMGKPSAPQEAEDNMKLLPVDCETKTDEFCQAKQKAALLELLHELYNFLAIQAGNFECGNPEKLKSKCIPVMEAQEYIANVTSSSSTKFEAALTWILSSNKDVGIWLKGEDPSELVTTVDKVVCLESSRPRMGVGCRLSRALLTAVTNLLIFFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIGAWPRGEGCWPPTAGPHPEQRPLSHRRGPGPLRGLGAGHGALPIRGHPARARHPDPSAEPEAHEASVGPGGGVPGLQRIPDPDGVPPRGRGRYAGVEMD", "length": 510, "header": "tr|A0AAA9U055-1|E1B828_BOVIN Computationally mapped isoform of LEM domain-containing protein 2 OS=Bos taurus OX=9913 GN=LEMD2 PE=4 SV=1 CANONICAL=E1B828-1" }, "locus": { "chromosome": "23", "start_pos": 7914716, "end_pos": 7899607, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118060.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118060.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103258.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103258.1" } ] } }, { "isoform_ac": "E1B828-1", "url": "https://www.uniprot.org/uniprotkb/E1B828/entry#E1B828-1", "sequence": { "sequence": "MAGLSDLELRRELQALGFQPGPITDTTRDVYRNKLRRLRGEARLRGEERPREAARAQGEEARLREEAPLRARPAAASPRAEPWLSPAASGPVYATPGAYGDIGDPAASWSGSRGLARPAPLRRRASARGSSEEDEDGRPFGRTAPGASPGLRRWWAASPASARPPSALLGPDPRPGLRATRAGPAASARARPEAGRRLERCLSRLLLWASLGLLLVFLGILWVKMGKPSAPQEAEDNMKLLPVDCETKTDEFCQAKQKAALLELLHELYNFLAIQAGNFECGNPEKLKSKCIPVMEAQEYIANVTSSSSTKFEAALTWILSSNKDVGIWLKGEDPSELVTTVDKVVCLESSRPRMGVGCRLSRALLTAVTNLLIFFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDTLIPPQSRRRMKRVWDRAVEFLASNESRIQTESHRVAGEDMLVWRWTKPSSFSDSER", "length": 495, "header": "tr|E1B828-1|E1B828_BOVIN Isoform 1 of LEM domain-containing protein 2 OS=Bos taurus OX=9913 GN=LEMD2 PE=4 SV=1 CANONICAL=E1B828-1" }, "locus": { "chromosome": "23", "start_pos": 7914716, "end_pos": 7899576, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020642.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020642.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020642.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020642.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 95, "start_aa": "Thr", "end_pos": 95, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr95", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:518023", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518023", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287ATT0-1", "protein_name": "LEM domain-containing protein 2", "gene_name": "LEMD2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGLSDLELRRELQALGFQPGPITDTTRDVYRNKLRRLRGEARLRGEERLREEARARGEERLREEARLRGEERLREEARLRGEERLREEARLREEAPLRARPAAASLRSEPWLSSPASGSAYAPSGAYGDLGVSPPSWSGSRGLAYSSRPAPLRRRASARGSSEEDEDSRTPDRAAPSPGHGVRRWWASAPTTARPSSALFSPDPRPGLRPTRASPTGAARARPEVGRRLERWLSRLLLWASLGLLLAFLGILWVKMGQPSAPQEARDSMKLLPVDCERKTDEFCQAKQKAALLELLHELYNFLATQAGNFECGNPEKLKSKCIPVTEAQEYIANVTSSSSAKFEAALTWILSSNKDVGIWLKGEDPSELVTTVDKVVCLESARPRMGVACRLSRALLTAATHVLIFFWCLAFLWGLLIFLRYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDTLIPPQSRRRMKRIWDRAVEFLASNESRIQTESHRVAGEDMLVWRWTKPSAFSDSER", "length": 527 }, "evidence": [ { "id": "E1B828", "url": "https://omabrowser.org/oma/group/E1B828/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6DVA0-1", "protein_name": "LEM domain-containing protein 2", "gene_name": "Lemd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGLSDLELRRELQALGFQPGPITDTTRNVYRNKLRRLRGEARLRDDERLREDAGPREDAGPRGPERQREEARLREEAPLRARPAASVLRSEPWPLSPSPPAPSAASDASGPYGNFGASASPWAASRGLSYPPHAGPGPLRRRASVRGSSEDDEDTRTPDRHAPGRGRHWWAPPSASARPHSALLGADARPGLKGSRTGSAGAGRTRPEVGRWLERCLSRLLLWASLGLLLGFLAILWVKMGKPSAPQEAEDNMKLLPVDCERKTDEFCQAKQKAALLELLHELYNFLAIQAGNFECGNPEKLKSKCIPVLEAQEYIANVTSSPSSRFKAALTWILSSNKDVGIWLKGEDPSELATTVDKVVCLESARPRMGIGCRLSRALLTAVTHVLIFFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDSLIPPQSRRRMKRVWDRAVEFLASNESRIQTESHRVAGEDMLVWRWTKPSSFSDSER", "length": 511 }, "evidence": [ { "id": "E1B828", "url": "https://omabrowser.org/oma/group/E1B828/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NC56-1", "protein_name": "LEM domain-containing protein 2", "gene_name": "LEMD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGLSDLELRRELQALGFQPGPITDTTRDVYRNKLRRLRGEARLRDEERLREEARPRGEERLREEARLREDAPLRARPAAASPRAEPWLSQPASGSAYATPGAYGDIRPSAASWVGSRGLAYPARPAQLRRRASVRGSSEEDEDARTPDRATQGPGLAARRWWAASPAPARLPSSLLGPDPRPGLRATRAGPAGAARARPEVGRRLERWLSRLLLWASLGLLLVFLGILWVKMGKPSAPQEAEDNMKLLPVDCERKTDEFCQAKQKAALLELLHELYNFLAIQAGNFECGNPENLKSKCIPVMEAQEYIANVTSSSSAKFEAALTWILSSNKDVGIWLKGEDQSELVTTVDKVVCLESAHPRMGVGCRLSRALLTAVTNVLIFFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDSLIPPQSRRRMKRVWDRAVEFLASNESRIQTESHRVAGEDMLVWRWTKPSSFSDSER", "length": 503 }, "evidence": [ { "id": "E1B828", "url": "https://omabrowser.org/oma/group/E1B828/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "E1B828", "url": "https://www.uniprot.org/uniprotkb/E1B828" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "E1B828", "url": "https://www.uniprot.org/uniprotkb/E1B828" } ], "pmid": "" }, { "name": "nuclear inner membrane", "id": "GO:0005637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005637", "evidence": [ { "database": "UniProtKB", "id": "E1B828", "url": "https://www.uniprot.org/uniprotkb/E1B828" } ], "pmid": "" }, { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "E1B828", "url": "https://www.uniprot.org/uniprotkb/E1B828" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051898", "evidence": [ { "database": "UniProtKB", "id": "E1B828", "url": "https://www.uniprot.org/uniprotkb/E1B828" } ], "pmid": "" }, { "name": "nuclear envelope organization", "id": "GO:0006998", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006998", "evidence": [ { "database": "UniProtKB", "id": "E1B828", "url": "https://www.uniprot.org/uniprotkb/E1B828" } ], "pmid": "" }, { "name": "neurogenesis", "id": "GO:0022008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022008", "evidence": [ { "database": "UniProtKB", "id": "E1B828", "url": "https://www.uniprot.org/uniprotkb/E1B828" } ], "pmid": "" }, { "name": "heart formation", "id": "GO:0060914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060914", "evidence": [ { "database": "UniProtKB", "id": "E1B828", "url": "https://www.uniprot.org/uniprotkb/E1B828" } ], "pmid": "" }, { "name": "protein localization to chromatin", "id": "GO:0071168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071168", "evidence": [ { "database": "UniProtKB", "id": "E1B828", "url": "https://www.uniprot.org/uniprotkb/E1B828" } ], "pmid": "" }, { "name": "negative regulation of BMP signaling pathway", "id": "GO:0030514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030514", "evidence": [ { "database": "UniProtKB", "id": "E1B828", "url": "https://www.uniprot.org/uniprotkb/E1B828" } ], "pmid": "" }, { "name": "skeletal muscle cell differentiation", "id": "GO:0035914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035914", "evidence": [ { "database": "UniProtKB", "id": "E1B828", "url": "https://www.uniprot.org/uniprotkb/E1B828" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "chromatin DNA binding", "id": "GO:0031490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031490", "evidence": [ { "database": "UniProtKB", "id": "E1B828", "url": "https://www.uniprot.org/uniprotkb/E1B828" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 303, "end_pos": 305, "annotation": "n_glycosylation_sequon" }, { "start_pos": 463, "end_pos": 465, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B828-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 495, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B828-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B828" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B828" }, { "id": "PS50954", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50954" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LEM", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 42, "start_aa": "Met", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 95 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 303, "end_pos": 305 }, { "start_pos": 463, "end_pos": 465 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCL9-1", "uniprot_ac": "E1BCL9", "uniprot_id": "E1BCL9_BOVIN", "mass": { "chemical_mass": 76012.0, "monoisotopic_mass": 76012.0 }, "refseq": { "ac": "XP_010807426", "name": "zinc finger protein 219", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807426" }, "gene_names": [ { "name": "ZNF219", "type": "recommended", "evidence": [ { "id": "E1BCL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCL9" } ] }, { "name": "ZNF219", "type": "synonym", "evidence": [ { "id": "XP_010807426", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807426" } ] } ], "protein_names": [ { "name": "Zinc finger protein 219", "type": "recommended", "evidence": [ { "id": "E1BCL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCL9/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 219", "type": "synonym", "evidence": [ { "id": "XP_010807426", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807426" } ] } ], "function": [ { "annotation": "Transcriptional regulator. Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3'. Binds to the HMGN1 promoter and may repress HMGN1 expression. Regulates SNCA expression in primary cortical neurons. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9. Plays a role in chondrocyte differentiation.", "evidence": [ { "database": "UniProtKB", "id": "E1BCL9", "url": "https://www.uniprot.org/uniprotkb/E1BCL9#function" }, { "database": "UniProtKB", "id": "ARBA00055818", "url": "https://www.uniprot.org/uniprotkb/ARBA00055818#function" }, { "database": "UniProtKB", "id": "A0AAA9S147", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S147#function" }, { "database": "UniProtKB", "id": "A0AAA9TG27", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG27#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCL9", "url": "https://www.uniprot.org/uniprotkb/E1BCL9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF219", "url": "https://www.uniprot.org/uniprotkb/E1BCL9", "locus": { "chromosome": "10", "start_pos": 26001853, "end_pos": 25986954, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021008", "url": "https://www.ensembl.org/id/ENSBTAG00000021008" } ] } } ], "crossref": [ { "id": "E1BCL9", "url": "https://alphafold.ebi.ac.uk/entry/E1BCL9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021008", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021008", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615493", "url": "https://www.ncbi.nlm.nih.gov/gene/615493", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615493", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615493", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EESWTRG", "url": "https://omabrowser.org/oma/group/EESWTRG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCL9", "url": "https://www.orthodb.org/?gene=E1BCL9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45925", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45925", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45925:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45925:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010807426", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807426", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S147", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S147", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S147-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S147-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG27", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG27", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG27-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG27-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCL9", "url": "https://www.uniprot.org/uniprotkb/E1BCL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCL9-1", "url": "https://www.uniprot.org/uniprotkb/E1BCL9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGSRPRAPVGHLAPSPPAFDGELDLQRYSNGPGVSAGSPGMGAVGWSESRAGERRFPCPVCGKRFRFNSILALHLRAHPGAQAFQCPHCGHRAAQRALLRSHLRTHQPERPRSPAARLLLELEERALLREARLGRPRSSGGLQATPATEGLPRPQASSSSAFRCPFCKGKFRTAAERERHLHILHRPWKCGLCSFGSSQEEELLHHSLTAHGAPERPLAATSAAPQPQPPPQPEPRSVPEPEPEPESEATPAPAPAAPEEPPAPPEFRCQVCGQSFTQSWFLKGHMRKHKASFDHACPVCGRCFKEPWFLKNHMKVHASKLGPLRAPGPGSGPARAPQPPDLGLLAYEPLGPALLLAPAPTPAERREPPSLLGYLSLRAGEARPNGEGAEPGAGRSFGSFRPLPSALPARARRHRAEEPDEEEEVVEAEEETWARSRAVGPLASLPSRPGEAPGHSAPAAGAQARSTATQEENGLLVGGARPEGGRGATGKDCPFCGKSFRSAHHLKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHLQRHHREQKSGAGPGPPPEPPPPSQRGSGQSSGAKAAPQPATWVEGRASPRPPASGGAPGSRRKPASPGRTLRNGRGGEAEPLDLSLRAGPGGEAGPGGALHRCLFCPFATGAPELMALHLQVHHSRRARGRRPPQADASPPYARAPSGETPPTPPQEGEEGPGLLRSGEAGLGGQER", "length": 716, "header": "tr|E1BCL9-1|E1BCL9_BOVIN Isoform 1 of Zinc finger protein 219 OS=Bos taurus OX=9913 GN=ZNF219 PE=3 SV=1 CANONICAL=E1BCL9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S147-1", "url": "https://www.uniprot.org/uniprotkb/E1BCL9/entry#A0AAA9S147-1", "sequence": { "sequence": "MSVRRTPIPALCEFGGSRPRAPVGHLAPSPPAFDGELDLQRYSNGPGVSAGSPGMGAVGWSESRAGERRFPCPVCGKRFRFNSILALHLRAHPGAQAFQCPHCGHRAAQRALLRSHLRTHQPERPRSPAARLLLELEERALLREARLGRPRSSGGLQATPATEGLPRPQASSSSAFRCPFCKGKFRTAAERERHLHILHRPWKCGLCSFGSSQEEELLHHSLTAHGAPERPLAATSAAPQPQPPPQPEPRSVPEPEPEPESEATPAPAPAAPEEPPAPPEFRCQVCGQSFTQSWFLKGHMRKHKASFDHACPVCGRCFKEPWFLKNHMKVHASKLGPLRAPGPGSGPARAPQPPDLGLLAYEPLGPALLLAPAPTPAERREPPSLLGYLSLRAGEARPNGEGAEPGAGRSFGSFRPLPSALPARARRHRAEEPDEEEEVVEAEEETWARSRAVGPLASLPSRPGEAPGHSAPAAGAQARSTATQEENGLLVGGARPEGGRGATGKDCPFCGKSFRSAHHLKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHLQRHHREQKSGAGPGPPPEPPPPSQRGSGQSSGAKAAPQPATWVEGRASPRPPASGGAPGSRRKPASPGRTLRNGRGGEAEPLDLSLRAGPGGEAGPGGALHRCLFCPFATGAPELMALHLQVHHSRRARGRRPPQADASPPYARAPSGETPPTPPQEGEEGPGLLRSGEAGLGGQER", "length": 729, "header": "tr|A0AAA9S147-1|E1BCL9_BOVIN Computationally mapped isoform of Zinc finger protein 219 OS=Bos taurus OX=9913 GN=ZNF219 PE=3 SV=1 CANONICAL=E1BCL9-1" }, "locus": { "chromosome": "10", "start_pos": 26000849, "end_pos": 25986988, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089839.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089839.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078699.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078699.1" } ] } }, { "isoform_ac": "A0AAA9TG27-1", "url": "https://www.uniprot.org/uniprotkb/E1BCL9/entry#A0AAA9TG27-1", "sequence": { "sequence": "MSPPQLSLLHPSLCSHFSPQGSRPRAPVGHLAPSPPAFDGELDLQRYSNGPGVSAGSPGMGAVGWSESRAGERRFPCPVCGKRFRFNSILALHLRAHPGAQAFQCPHCGHRAAQRALLRSHLRTHQPERPRSPAARLLLELEERALLREARLGRPRSSGGLQATPATEGLPRPQASSSSAFRCPFCKGKFRTAAERERHLHILHRPWKCGLCSFGSSQEEELLHHSLTAHGAPERPLAATSAAPQPQPPPQPEPRSVPEPEPEPESEATPAPAPAAPEEPPAPPEFRCQVCGQSFTQSWFLKGHMRKHKASFDHACPVCGRCFKEPWFLKNHMKVHASKLGPLRAPGPGSGPARAPQPPDLGLLAYEPLGPALLLAPAPTPAERREPPSLLGYLSLRAGEARPNGEGAEPGAGRSFGSFRPLPSALPARARRHRAEEPDEEEEVVEAEEETWARSRAVGPLASLPSRPGEAPGHSAPAAGAQARSTATQEENGLLVGGARPEGGRGATGKDCPFCGKSFRSAHHLKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHLQRHHREQKSGAGPGPPPEPPPPSQRGSGQSSGAKAAPQPATWVEGRASPRPPASGGAPGSRRKPASPGRTLRNGRGGEAEPLDLSLRAGPGGEAGPGGALHRCLFCPFATGAPELMALHLQVHHSRRARGRRPPQADASPPYARAPSGETPPTPPQEGEEGPGLLRSGEAGLGGQER", "length": 734, "header": "tr|A0AAA9TG27-1|E1BCL9_BOVIN Computationally mapped isoform of Zinc finger protein 219 OS=Bos taurus OX=9913 GN=ZNF219 PE=3 SV=1 CANONICAL=E1BCL9-1" }, "locus": { "chromosome": "10", "start_pos": 26000849, "end_pos": 25998130, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133684.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133684.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097128.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097128.1" } ] } }, { "isoform_ac": "E1BCL9-1", "url": "https://www.uniprot.org/uniprotkb/E1BCL9/entry#E1BCL9-1", "sequence": { "sequence": "MEGSRPRAPVGHLAPSPPAFDGELDLQRYSNGPGVSAGSPGMGAVGWSESRAGERRFPCPVCGKRFRFNSILALHLRAHPGAQAFQCPHCGHRAAQRALLRSHLRTHQPERPRSPAARLLLELEERALLREARLGRPRSSGGLQATPATEGLPRPQASSSSAFRCPFCKGKFRTAAERERHLHILHRPWKCGLCSFGSSQEEELLHHSLTAHGAPERPLAATSAAPQPQPPPQPEPRSVPEPEPEPESEATPAPAPAAPEEPPAPPEFRCQVCGQSFTQSWFLKGHMRKHKASFDHACPVCGRCFKEPWFLKNHMKVHASKLGPLRAPGPGSGPARAPQPPDLGLLAYEPLGPALLLAPAPTPAERREPPSLLGYLSLRAGEARPNGEGAEPGAGRSFGSFRPLPSALPARARRHRAEEPDEEEEVVEAEEETWARSRAVGPLASLPSRPGEAPGHSAPAAGAQARSTATQEENGLLVGGARPEGGRGATGKDCPFCGKSFRSAHHLKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHLQRHHREQKSGAGPGPPPEPPPPSQRGSGQSSGAKAAPQPATWVEGRASPRPPASGGAPGSRRKPASPGRTLRNGRGGEAEPLDLSLRAGPGGEAGPGGALHRCLFCPFATGAPELMALHLQVHHSRRARGRRPPQADASPPYARAPSGETPPTPPQEGEEGPGLLRSGEAGLGGQER", "length": 716, "header": "tr|E1BCL9-1|E1BCL9_BOVIN Isoform 1 of Zinc finger protein 219 OS=Bos taurus OX=9913 GN=ZNF219 PE=3 SV=1 CANONICAL=E1BCL9-1" }, "locus": { "chromosome": "10", "start_pos": 26000849, "end_pos": 25997903, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027974.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027974.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027974.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027974.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 146, "start_aa": "Thr", "end_pos": 146, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr146", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 251, "start_aa": "Thr", "end_pos": 251, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr251", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 362, "start_aa": "Thr", "end_pos": 362, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr362", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 692, "start_aa": "Thr", "end_pos": 692, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr692", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:615493", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615493", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AD89-1", "protein_name": "Zinc finger protein 219", "gene_name": "ZNF219", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEGSRPRAPGGHLAPSPPAFDGELDLQRYSNGPGVSSGSPGMGAVGWSESRAGERRFPCPVCGKRFRFNSILALHLRAHPGAQAFQCPHCGHRAAQRALLRSHLRTHQPERPRSPAARLLLELEERALLREARLGRPRSSGGLQATPATEALGRPQAPSSSAFRCPFCKGKFRTAAERERHLHILHRPWKCGLCSFGSSQEEELLHHSLTAHGAPDRPLAATSAAPQPQPPPQPEARCVPEPDPEPEREATPAPAPAAPEEPPAPPEFRCQVCGQSFTQSWFLKGHMRKHKASFDHACPVCGRCFKEPWFLKNHMKVHASKLGPLRAPGPGSGPARAPQPPDLGLLAYEPLGPALLLAPAPTPAERREPPSLLGYLSLRAGEARPNGEGAEPGAGRSFGGFRPLPSALPARARRHRTEEPEEEEEMVETEEETWARSRALGPLASLPPRPGEGSGHNAPAAGAQARSTTTQEENGLLVGGTRPEGGRGATGKDCPFCGKSFRSAHHLKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHLQRHHREQKSGAGPGPPPEPPPSSQRGSAQSSGPKPAPQPATWVEGTASPRPPSRGAAPGSRRKPASPGRTLRNGRGGEAEPLDLSLRAGPGGEAGPGGALHRCLFCPFATGAPELMALHLQVHHSRRARGRRPPQADASPPYARPPSGETPPSPPQEGEEGPGLLRSGEAGLGGQER", "length": 716 }, "evidence": [ { "id": "E1BCL9", "url": "https://omabrowser.org/oma/group/E1BCL9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6IQX8-1", "protein_name": "Zinc finger protein 219", "gene_name": "Znf219", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGSRPRILVGHLEPSPPAFDGELDLQRYSNGPGVSGTPGPGSPGMGAVGWSETRAGERRFPCPVCGKRFRFNSILALHLRAHPGAQAFQCPHCGHRAAQRALLRSHLRTHQPERPRSPAARLLLELEERALLREARLGRARSSGGMQSSPAAEGLARPQVPSSSAFRCPFCKGKFRTSAERERHLHILHRPWKCSLCSFGSSQEEELLHHSLTAHGASERPLAATSTPEPPPPPQQEPRSALEPEPEPEPRPEPDREANPAPTPAPPEEPPAPPEFRCQVCGQSFTQSWFLKGHMRKHKASFDHACPVCGRCFKEPWFLKNHMKVHTSKLGPLRAPGPGSAPARAPQPPDLSLLAYEPLGPALLLAPAPAPAERREPPSLLGYLSVRAGEVRPNGEGADPGGGRSYGGFRPLPSALPNRARRHRTEEPEEEEEVVEAEEESWARGRSLGSLTSLHPNPGEGSGQPAPAAGTQARSTATQEENGLLVGGTRSEAGRGATGKDCPFCGKSFRSAHHLKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHLQRHHREQRSSAGPGPPPEPPPPSQRGSLQPQSGAKPTQASATWVEGTASTRPPSSSTGPGSRRKPASPGRTLRNGRGGEAEPLDLSLRAGPGGEAGAGGALHRCLFCPFATGAPELMALHLQVHHSRRARGRRQPRADTSPTYVRAPSGETPPSPPLEEEGSPGLSRSGEAGLGGQER", "length": 726 }, "evidence": [ { "id": "E1BCL9", "url": "https://omabrowser.org/oma/group/E1BCL9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P2Y4-1", "protein_name": "Zinc finger protein 219", "gene_name": "ZNF219", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGSRPRAPSGHLAPSPPAFDGELDLQRYSNGPAVSAGSLGMGAVSWSESRAGERRFPCPVCGKRFRFNSILALHLRAHPGAQAFQCPHCGHRAAQRALLRSHLRTHQPERPRSPAARLLLELEERALLREARLGRARSSGGMQATPATEGLARPQAPSSSAFRCPYCKGKFRTSAERERHLHILHRPWKCGLCSFGSSQEEELLHHSLTAHGAPERPLAATSAAPPPQPQPQPPPQPEPRSVPQPEPEPEPEREATPTPAPAAPEEPPAPPEFRCQVCGQSFTQSWFLKGHMRKHKASFDHACPVCGRCFKEPWFLKNHMKVHASKLGPLRAPGPASGPARAPQPPDLGLLAYEPLGPALLLAPAPTPAERREPPSLLGYLSLRAGEGRPNGEGAEPGPGRSFGGFRPLSSALPARARRHRAEEPEEEEEVVEAEEETWARGRSLGSLASLHPRPGEGPGHSASAAGAQARSTATQEENGLLVGGTRPEGGRGATGKDCPFCGKSFRSAHHLKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHLQRHHREQRSGAGPGPPPEPPPPSQRGSAPQSGAKPSPQPATWVEGASSPRPPSSGAGPGSRRKPASPGRTLRNGRGGEAEPLDLSLRAGPGGEAGPGGALHRCLFCPFATGAPELMALHLQVHHSRRARGRRPPQADASPPYARVPSGETPPSPSQEGEEGSGLSRPGEAGLGGQER", "length": 722 }, "evidence": [ { "id": "E1BCL9", "url": "https://omabrowser.org/oma/group/E1BCL9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BCL9", "url": "https://www.uniprot.org/uniprotkb/E1BCL9" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BCL9", "url": "https://www.uniprot.org/uniprotkb/E1BCL9" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "E1BCL9", "url": "https://www.uniprot.org/uniprotkb/E1BCL9" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BCL9", "url": "https://www.uniprot.org/uniprotkb/E1BCL9" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "E1BCL9", "url": "https://www.uniprot.org/uniprotkb/E1BCL9" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BCL9", "url": "https://www.uniprot.org/uniprotkb/E1BCL9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BCL9", "url": "https://www.uniprot.org/uniprotkb/E1BCL9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BCL9", "url": "https://www.uniprot.org/uniprotkb/E1BCL9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BCL9", "url": "https://www.uniprot.org/uniprotkb/E1BCL9" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BCL9", "url": "https://www.uniprot.org/uniprotkb/E1BCL9" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "E1BCL9", "url": "https://www.uniprot.org/uniprotkb/E1BCL9" } ], "pmid": "" }, { "name": "positive regulation of chondrocyte differentiation", "id": "GO:0032332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032332", "evidence": [ { "database": "UniProtKB", "id": "E1BCL9", "url": "https://www.uniprot.org/uniprotkb/E1BCL9" } ], "pmid": "" }, { "name": "limb bud formation", "id": "GO:0060174", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060174", "evidence": [ { "database": "UniProtKB", "id": "E1BCL9", "url": "https://www.uniprot.org/uniprotkb/E1BCL9" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "E1BCL9", "url": "https://www.uniprot.org/uniprotkb/E1BCL9" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "E1BCL9", "url": "https://www.uniprot.org/uniprotkb/E1BCL9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCL9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 716, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCL9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCL9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCL9" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 57, "end_pos": 84, "start_aa": "Phe", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 146, 251, 362, 692 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B969-1", "uniprot_ac": "E1B969", "uniprot_id": "E1B969_BOVIN", "mass": { "chemical_mass": 346279.0, "monoisotopic_mass": 346279.0 }, "refseq": { "ac": "XP_002693195", "name": "protocadherin-16", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693195" }, "gene_names": [ { "name": "DCHS1", "type": "recommended", "evidence": [ { "id": "E1B969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B969" } ] }, { "name": "DCHS1", "type": "synonym", "evidence": [ { "id": "XP_002693195", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693195" } ] } ], "protein_names": [ { "name": "Protocadherin-16", "type": "recommended", "evidence": [ { "id": "E1B969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B969/entry#names_and_taxonomy" } ] }, { "name": "Protein dachsous homolog 1", "type": "synonym", "evidence": [ { "id": "E1B969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B969/entry#names_and_taxonomy" } ] }, { "name": "protocadherin-16", "type": "synonym", "evidence": [ { "id": "XP_002693195", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693195" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B969", "url": "https://www.uniprot.org/uniprotkb/E1B969" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DCHS1", "url": "https://www.uniprot.org/uniprotkb/E1B969", "locus": { "chromosome": "15", "start_pos": 46444339, "end_pos": 46407382, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015405", "url": "https://www.ensembl.org/id/ENSBTAG00000015405" } ] } } ], "crossref": [ { "id": "ENSBTAG00000015405", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015405", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515576", "url": "https://www.ncbi.nlm.nih.gov/gene/515576", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515576", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515576", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "STCQIRI", "url": "https://omabrowser.org/oma/group/STCQIRI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B969", "url": "https://www.orthodb.org/?gene=E1B969", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24025", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24025", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24025:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24025:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002693195", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693195", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S2A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2A5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2A5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2A5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B969", "url": "https://www.uniprot.org/uniprotkb/E1B969", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B969-1", "url": "https://www.uniprot.org/uniprotkb/E1B969-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQKEWATAPSCPGMQIPRPLPLLSLLMLLLLGAGAPGAWGQAGSLDLQIDEEQPAGTLIGDISAGLPAGTAAPPMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDRERRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQARAVLQIPEHTALGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGAPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAAVSESLAPGSPVLQVYASDADAGANGAVTYEINRRQSEGDGPFSIDAHTGLLRLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPRVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVARVTARDPDQGTNGQVTYSLAPGAHTRWFSIDPTSGIVTTAALLDYELEPQPQLIVVATDGGLPPLSSSATVSVVLQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGTSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFVSDENDNPPQFYPREYAASLSAQSAPGTAVLRVRAHDPDQGPHGRLSYHILAGNSPPLFALDEHSGLLTVAWPLARRASSMVQLEIGARDGGGLQAEPNARVNISIVPGTPVPPVFEQLQYVFSVPEDVAPGTSVGVVQAHNPPGRLGPVTLALSGGDPRGLFSLDGATGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPSSTAPGTLIYTLRALDPDSGVNSRVTFTLLAGGGGTFTVDPTTGHIRLMGPLGPPGGPAHELELEARDGGSPPRTSHFRLRVVVQDLGTRGLAPHFDSPTYRVDLPSGTTPGTQVLQVQARAPDGSPVTYHLAADGPGSPFGLEPQSGWLWVRAALDHEAQELYTLKVMAVSGSKAELGQQTATATVRISILNQNDHSPRLSEEPTFLAVAENQPPGTSVGRVFATDRDSGINGRLTYSLRQLSEDSKAFRIHPQTGEVTTLQTLDRERQNSYQLLVQVQDAGSPPRSTTGTVHIAVLDLNDNSPTFLQASGAAGGGLPIQVPDGVPPGTLVTTLQAKDPDEGENGTILYMLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSSSLQLLVQVLPSTRSAEPAPEPSEPDPVAPVPVVLTVTAAEGLRPGSLLGSVAPLEQAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPAWRALTVRAEGPGGAGARLLRVQVRVQDENEHAPAFARDPLALALPENPEPGATLYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRTARVSARVFVTDENDNAPVFASPSRVRLPEDHPPGPTALHVVARDPDLGEAARVSYRLAAGADGCFRLHPSTGALSVVRSLDREQRAEYVLTVVASDHGSPPRSATQLLTVSVADVNDEAPAFQQQEYSVLLRENSPPGTSLLTLQATDPDLGANGQVTYGGISGENFSLDPDTGVLTTLRALDREEQEEINLTVYARDGGSPPLLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTTLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLQIEARDGGQPALSATLLVTVTVLDANDHAPAFPVPSYSVEVPEDAPAGTLLLQLQAHDPDAGANGRVTYYLGTGAAGAFLLEPSSGELRTATTLDREQCPSYAFTVNAVDSAAAGPLSTTVPVTITVRDVNDHAPTFPTSPLRLRLPRPGPVFSTPVLPLATLRAEDRDTGANASILYRLAGTPPPGTTVDSYTGEIRVSRSPVSLSPRDRVLFIVATDLGRPARSATGVVIIGLQGESEHGPRFSRASSEAMLRENAPPGTPVVSPKAIHAGGSSGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEANPRLRLVLQAESGGAYAFSVLTLTLQDANDNAPRFLQPHYVAFLPESRPLEGPLLQVEADDLDQGPSGQISYSLAASQPARGLFHVDPATGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRLSLTGPLDFEQRDRYHLQLLAHDGPHEGQANLTVFVEDVNDNSPAFSQTLYQVMLLEHTPPGSAILSVSATDRDSGANGHVSYHLASSAEGFSIDPNNGTLFTTVGTVALGHEGPGMVDVVLEARDHGVPVRAARATVHVQLQDQNDHAPSFTLPHYRVAVTEDLPPGSTLLTLEATDADGSRSHATVDYSIVSGNRGRVFQLEPRLAEAGESDGLGPRALGCLVLLEPLDFESLTQYNLTVAATDRGQPPRSSAVPVTVSVLDVNDNPPVFTRAAYRVAVPEDTPVGAELLHVEASDADPGPHGLVRFTLSSGDPLGLFELDESSGDLRLARPLDCETQARHQLVVQASDPAGVHFALAPVTIEVQDVNDHGPAFPLSLLSTSLAENQPPGTLVTTLHAIDGDAGAFGRLHYSLLEAGPGPEGREAFALNSSTGELRARVAFDYEHTGSFQLLVGATDAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLAASSPYFGINQTTGALYLRVDSRAPGSGTGTSGGGGRTRREAPRELRLEVVARGPLPGSRSATVPVTVDITHTALGLAPDLNLLLVGAVAASLGVVVVLALAALVLGLVRARSRKAEAAPGPMSQAAPLASGSLQKLGREPPSPPPSEHLYHQTLPSYGGPGAGGPYPRGGSLDPSHSSGRGSAEAAEDDEIRMINEFPRVASVASSLAARGPDSGIQQDADGLSDTSCEPPAPDTWYKGRKAGLLLPGAGATLYREDGPPATATTFLGGCGLSPAPTGDYGFPADGKPCVAGALTAIVAGEEELRGSYNWDYLLSWCPQFQPLASVFTEIARLKDEARPCPPAPRIDPPPLITAVAHPGAKSVPPKPASTAATRAVFPPASHRSPISHEGSLSSAAMSPSFSPSLSPLAARSPVVSPFGVAQGPSASALSAESGLEPPDDTELHI", "length": 3296, "header": "tr|E1B969-1|E1B969_BOVIN Isoform 1 of Protocadherin-16 OS=Bos taurus OX=9913 GN=DCHS1 PE=4 SV=3 CANONICAL=E1B969-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2A5-1", "url": "https://www.uniprot.org/uniprotkb/E1B969/entry#A0AAA9S2A5-1", "sequence": { "sequence": "MPWHLQAKAPLMGSSYWIPSPSWVPAACPCLQLWCLCFQVKESELEPGSKLDLIQNLRSSCSWSLAWSWIPRHSWTGPAMQKEWATAPSCPGMQIPRPLPLLSLLMLLLLGAGAPGAWGQAGSLDLQIDEEQPAGTLIGDISAGLPAGTAAPPMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDRERRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQARAVLQIPEHTALGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGAPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAAVSESLAPGSPVLQVYASDADAGANGAVTYEINRRQSEGDGPFSIDAHTGLLRLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPRVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVARVTARDPDQGTNGQVTYSLAPGAHTRWFSIDPTSGIVTTAALLDYELEPQPQLIVVATDGGLPPLSSSATVSVVLQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGTSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFVSDENDNPPQFYPREYAASLSAQSAPGTAVLRVRAHDPDQGPHGRLSYHILAGNSPPLFALDEHSGLLTVAWPLARRASSMVQLEIGARDGGGLQAEPNARVNISIVPGTPVPPVFEQLQYVFSVPEDVAPGTSVGVVQAHNPPGRLGPVTLALSGGDPRGLFSLDGATGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPSSTAPGTLIYTLRALDPDSGVNSRVTFTLLAGGGGTFTVDPTTGHIRLMGPLGPPGGPAHELELEARDGGSPPRTSHFRLRVVVQDLGTRGLAPHFDSPTYRVDLPSGTTPGTQVLQVQARAPDGSPVTYHLAADGPGSPFGLEPQSGWLWVRAALDHEAQELYTLKVMAVSGSKAELGQQTATATVRISILNQNDHSPRLSEEPTFLAVAENQPPGTSVGRVFATDRDSGINGRLTYSLRQLSEDSKAFRIHPQTGEVTTLQTLDRERQNSYQLLVQVQDAGSPPRSTTGTVHIAVLDLNDNSPTFLQASGAAGGGLPIQVPDGVPPGTLVTTLQAKDPDEGENGTILYMLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSSSLQLLVQVLPSTRSAEPAPEPSEPDPVAPVPVVLTVTAAEGLRPGSLLGSVAPLEQAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPAWRALTVRAEGPGGAGARLLRVQVRVQDENEHAPAFARDPLALALPENPEPGATLYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRTARVSARVFVTDENDNAPVFASPSRVRLPEDHPPGPTALHVVARDPDLGEAARVSYRLAAGADGCFRLHPSTGALSVVRSLDREQRAEYVLTVVASDHGSPPRSATQLLTVSVADVNDEAPAFQQQEYSVLLRENSPPGTSLLTLQATDPDLGANGQVTYGGISGENFSLDPDTGVLTTLRALDREEQEEINLTVYARDGGSPPLLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTTLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLQIEARDGGQPALSATLLVTVTVLDANDHAPAFPVPSYSVEVPEDAPAGTLLLQLQAHDPDAGANGRVTYYLGTGAAGAFLLEPSSGELRTATTLDREQCPSYAFTVNAVDSAAAGPLSTTVPVTITVRDVNDHAPTFPTSPLRLRLPRPGPVFSTPVLPLATLRAEDRDTGANASILYRLAGTPPPGTTVDSYTGEIRVSRSPVSLSPRDRVLFIVATDLGRPARSATGVVIIGLQGESEHGPRFSRASSEAMLRENAPPGTPVVSPKAIHAGGSSGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEANPRLRLVLQAESGGAYAFSVLTLTLQDANDNAPRFLQPHYVAFLPESRPLEGPLLQVEADDLDQGPSGQISYSLAASQPARGLFHVDPATGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRLSLTGPLDFEQRDRYHLQLLAHDGPHEGQANLTVFVEDVNDNSPAFSQTLYQVMLLEHTPPGSAILSVSATDRDSGANGHVSYHLASSAEGFSIDPNNGTLFTTVGTVALGHEGPGMVDVVLEARDHGVPVRAARATVHVQLQDQNDHAPSFTLPHYRVAVTEDLPPGSTLLTLEATDADGSRSHATVDYSIVSGNRGRVFQLEPRLAEAGESDGLGPRALGCLVLLEPLDFESLTQYNLTVAATDRGQPPRSSAVPVTVSVLDVNDNPPVFTRAAYRVAVPEDTPVGAELLHVEASDADPGPHGLVRFTLSSGDPLGLFELDESSGDLRLARPLDCETQARHQLVVQASDPAGVHFALAPVTIEVQDVNDHGPAFPLSLLSTSLAENQPPGTLVTTLHAIDGDAGAFGRLHYSLLEAGPGPEGREAFALNSSTGELRARVAFDYEHTGSFQLLVGATDAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLAASSPYFGINQTTGALYLRVDSRAPGSGTGTSGGGGRTRREAPRELRLEVVARGPLPGSRSATVPVTVDITHTALGLAPDLNLLLVGAVAASLGVVVVLALAALVLGLVRARSRKAEAAPGPMSQAAPLASGSLQKLGREPPSPPPSEHLYHQTLPSYGGPGAGGPYPRGGSLDPSHSSGRGSAEAAEDDEIRMINEFPRVASVASSLAARGPDSGIQQDADGLSDTSCEPPAPDTWYKGRKAGLLLPGAGATLYREDGPPATATTFLGGCGLSPAPTGDYGFPADGKPCVAGALTAIVAGEEELRGSYNWDYLLSWCPQFQPLASVFTEIARLKDEARPCPPAPRIDPPPLITAVAHPGAKSVPPKPASTAATRAVFPPASHRSPISHEGSLSSAAMSPSFSPSLSPLAARSPVVSPFGVAQGPSASALSAESGLEPPDDTELHI", "length": 3375, "header": "tr|A0AAA9S2A5-1|E1B969_BOVIN Computationally mapped isoform of Protocadherin-16 OS=Bos taurus OX=9913 GN=DCHS1 PE=4 SV=1 CANONICAL=E1B969-1" }, "locus": { "chromosome": "15", "start_pos": 46443679, "end_pos": 46412991, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112550.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112550.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077829.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077829.1" } ] } }, { "isoform_ac": "E1B969-1", "url": "https://www.uniprot.org/uniprotkb/E1B969/entry#E1B969-1", "sequence": { "sequence": "MQKEWATAPSCPGMQIPRPLPLLSLLMLLLLGAGAPGAWGQAGSLDLQIDEEQPAGTLIGDISAGLPAGTAAPPMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDRERRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQARAVLQIPEHTALGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGAPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAAVSESLAPGSPVLQVYASDADAGANGAVTYEINRRQSEGDGPFSIDAHTGLLRLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPRVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVARVTARDPDQGTNGQVTYSLAPGAHTRWFSIDPTSGIVTTAALLDYELEPQPQLIVVATDGGLPPLSSSATVSVVLQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGTSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFVSDENDNPPQFYPREYAASLSAQSAPGTAVLRVRAHDPDQGPHGRLSYHILAGNSPPLFALDEHSGLLTVAWPLARRASSMVQLEIGARDGGGLQAEPNARVNISIVPGTPVPPVFEQLQYVFSVPEDVAPGTSVGVVQAHNPPGRLGPVTLALSGGDPRGLFSLDGATGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPSSTAPGTLIYTLRALDPDSGVNSRVTFTLLAGGGGTFTVDPTTGHIRLMGPLGPPGGPAHELELEARDGGSPPRTSHFRLRVVVQDLGTRGLAPHFDSPTYRVDLPSGTTPGTQVLQVQARAPDGSPVTYHLAADGPGSPFGLEPQSGWLWVRAALDHEAQELYTLKVMAVSGSKAELGQQTATATVRISILNQNDHSPRLSEEPTFLAVAENQPPGTSVGRVFATDRDSGINGRLTYSLRQLSEDSKAFRIHPQTGEVTTLQTLDRERQNSYQLLVQVQDAGSPPRSTTGTVHIAVLDLNDNSPTFLQASGAAGGGLPIQVPDGVPPGTLVTTLQAKDPDEGENGTILYMLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSSSLQLLVQVLPSTRSAEPAPEPSEPDPVAPVPVVLTVTAAEGLRPGSLLGSVAPLEQAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPAWRALTVRAEGPGGAGARLLRVQVRVQDENEHAPAFARDPLALALPENPEPGATLYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRTARVSARVFVTDENDNAPVFASPSRVRLPEDHPPGPTALHVVARDPDLGEAARVSYRLAAGADGCFRLHPSTGALSVVRSLDREQRAEYVLTVVASDHGSPPRSATQLLTVSVADVNDEAPAFQQQEYSVLLRENSPPGTSLLTLQATDPDLGANGQVTYGGISGENFSLDPDTGVLTTLRALDREEQEEINLTVYARDGGSPPLLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTTLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLQIEARDGGQPALSATLLVTVTVLDANDHAPAFPVPSYSVEVPEDAPAGTLLLQLQAHDPDAGANGRVTYYLGTGAAGAFLLEPSSGELRTATTLDREQCPSYAFTVNAVDSAAAGPLSTTVPVTITVRDVNDHAPTFPTSPLRLRLPRPGPVFSTPVLPLATLRAEDRDTGANASILYRLAGTPPPGTTVDSYTGEIRVSRSPVSLSPRDRVLFIVATDLGRPARSATGVVIIGLQGESEHGPRFSRASSEAMLRENAPPGTPVVSPKAIHAGGSSGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEANPRLRLVLQAESGGAYAFSVLTLTLQDANDNAPRFLQPHYVAFLPESRPLEGPLLQVEADDLDQGPSGQISYSLAASQPARGLFHVDPATGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRLSLTGPLDFEQRDRYHLQLLAHDGPHEGQANLTVFVEDVNDNSPAFSQTLYQVMLLEHTPPGSAILSVSATDRDSGANGHVSYHLASSAEGFSIDPNNGTLFTTVGTVALGHEGPGMVDVVLEARDHGVPVRAARATVHVQLQDQNDHAPSFTLPHYRVAVTEDLPPGSTLLTLEATDADGSRSHATVDYSIVSGNRGRVFQLEPRLAEAGESDGLGPRALGCLVLLEPLDFESLTQYNLTVAATDRGQPPRSSAVPVTVSVLDVNDNPPVFTRAAYRVAVPEDTPVGAELLHVEASDADPGPHGLVRFTLSSGDPLGLFELDESSGDLRLARPLDCETQARHQLVVQASDPAGVHFALAPVTIEVQDVNDHGPAFPLSLLSTSLAENQPPGTLVTTLHAIDGDAGAFGRLHYSLLEAGPGPEGREAFALNSSTGELRARVAFDYEHTGSFQLLVGATDAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLAASSPYFGINQTTGALYLRVDSRAPGSGTGTSGGGGRTRREAPRELRLEVVARGPLPGSRSATVPVTVDITHTALGLAPDLNLLLVGAVAASLGVVVVLALAALVLGLVRARSRKAEAAPGPMSQAAPLASGSLQKLGREPPSPPPSEHLYHQTLPSYGGPGAGGPYPRGGSLDPSHSSGRGSAEAAEDDEIRMINEFPRVASVASSLAARGPDSGIQQDADGLSDTSCEPPAPDTWYKGRKAGLLLPGAGATLYREDGPPATATTFLGGCGLSPAPTGDYGFPADGKPCVAGALTAIVAGEEELRGSYNWDYLLSWCPQFQPLASVFTEIARLKDEARPCPPAPRIDPPPLITAVAHPGAKSVPPKPASTAATRAVFPPASHRSPISHEGSLSSAAMSPSFSPSLSPLAARSPVVSPFGVAQGPSASALSAESGLEPPDDTELHI", "length": 3296, "header": "tr|E1B969-1|E1B969_BOVIN Isoform 1 of Protocadherin-16 OS=Bos taurus OX=9913 GN=DCHS1 PE=4 SV=3 CANONICAL=E1B969-1" }, "locus": { "chromosome": "15", "start_pos": 46443679, "end_pos": 46422212, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020475.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020475.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020475.4", "url": "https://www.ensembl.org/id/ENSBTAP00000020475.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1012, "start_aa": "Thr", "end_pos": 1012, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1012", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1561, "start_aa": "Thr", "end_pos": 1561, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1561", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 944, "start_aa": "Thr", "end_pos": 944, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr944", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:515576", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515576", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0X9M6-1", "protein_name": "Protocadherin-16", "gene_name": "DCHS1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEQMKGSAMLLLELLILGGLRAEKGSAVLGTLDLQIDEEQPAGTIIGDISAGLPPGTSAYMYFISAQEGSGVTTDLWIDENRGIIKTARVLDRETRDHYSFIAVTPEGITVEVNIQVNDINDHAPAFPKQHSTFQIPEHTPVGSRFPLDPAFDADSGLLNTQGYMIKGDNVGQAFRLETRRGPNGVLYLDLVVSNVLDRENRSSYSLVLEAYDGGTPPRSSQMTLDVSIQDINDNAPAFNQSRYHTLISENLKPGSSILQVFASDADEGDNGDVIYEINRRQSDPDQYFTIDSRTGVIKLNKGLDYEVRKVHELVVQARDRAVHPEVTTAFVTIHVRDYNDNQPTMTIIFLSEDGSPQISEGAQPGQYVARISVSDPDYGEYSNVNVTLEGGDGKFALTTKDNIIYLICVDQLLDREERDSYDLRVTATDSGTPPLRAESTFVLQVIDINDNPPLFDQQEYKQSIPEVVYPGSFVLQVTARDKDQGPNGEVQYSIVHSHDTHSSWFAIDPATGIITTAAPLDYEKDPQPQLTVLATDRGTPALSSSAVVLVALQDVNDNEPVFRSNFYNVSLKENTPVGTCFLQVTATDADSGLFGSLSYSLGSGIGSVVPTQFSIDKHTGHLCTTQPLDRDEGTSAYDFTITAVDGGGLNSMVYVKVFLEDINDNRPVFYPLDYAASISTQSMPGTAVLRVTAHDKDEGMHGKVTYRIVLGNSPPLFSLNKDTGVISLSWSLSGKANTLVQLVISAEDGGGLQAQPNARVNISVVEGTVSPPVFEQAQYFFTVPEDMLQGASVGAVRAQNPPGHTDDIFYSISSGDPHGYFSIDSDTGQLHTSLPLDHESQAVLILDVQARSGSPPAYSNTRVKISVSDVNDNAPTFPSPSDSILLPEATEPGTTVYTLQAEDRDNGANGQVNFELVSGGDGTFSVERSSGAVRLVGVLQYEASAAYRLSIVARDSGVPQLSSTFTLLVHVQAEHDNGPIFDTLTYRVEVREGVPVSTRFLQVRALARDAEDVTLTYHLRADGDAASFGIMSESGWLYVKSALDRETRDLYVLTVLASAGGSGSGGEARKTGTSTVRISITDENDNSPRLSEERYFFTVPENQAPGSSVGRVMASDRDAGQNSRLTYRLLQHDSNFLIHTQTGELSTKHSLDRELQSSYQLLVIVQDGGAPPRSATGTIYVTVLDENDNAPVFLHITGGQELPVQVLEEKPSGLLVASLQAKDPDEGENGTITYSLTGAWAERFTLHTATGELRTATVLRRADRAEYVFTVTASDRGMVPCTTSAIVRIQVLPSSRLLPRPDATVLTLQPLEGVRPGSVIGSVAPPDAPTRGQLTYMVVGGGGDGTFVVDSVTGEIYAARELDYEARARHTLQVSAEDTQHGYPSSRLVLVQILVQDCNDQAPTFPEDPITIVVPENAQAGSSVFTFQALDGDGVGPNSQVRYALLRQEPPGAPFHLDSRSGLLSLHQSLDREAVASFLLVVEATDQARNVSQRRSSAVTARVFVTDVNDNAPVFLSPAAVSVTEDRPTGFVALHVVAQDNDLGENGRVSYSLRAGNGDGRFHLNPSTGALSVVRALNREEVVQHNLTVVAADHGFPRRSATQLLSILVLDVNDEAPTFEKPEYEAHVMENLPAGSPVLQVLATDRDLGANGQVTYGGLSGGPFSIHPQTGLIVTTHPLDREEQEQHVLMVYAQDGGLPPNLSKATVRITVGDENDHTPQLESESCSVEVPENQSRVALYTLRATDPDGDENGRLEYRVADGDPEQDFILDPVSGVLSTARALDREQVAFYSLTVVVQDHGTPPRSATMTVNVRVLDLNDNAPGFAQASYVVEVPEDLPVGSLVLQLEAEDPDEGTNGQVTYYLGNESLGMFQIEPQSGRIRSAQELDRERQPSYSFLAKAVDSAPWEPKSAAVRVTVTVRDVNDHAPAFLHSPVTVSLSRHTPLKQVVATMRAEDRDAGANASILYRLATPNSAFSINSYTGDIQLLQPLSSLSQRQRTLFILATDLGQPALSSTGVVVIHVQEEPYRGLRFPRSTSEVVLPENAAPGTAVTSIQAVHMGGSSGRITYSIISGNEKNAFLIQPSSGAISVQDSSSLDFEASPRLRLVVQAETTASFGFMAINLNLQDVNDNLPRFQLQNYVAFIWESQSYDSPVIQVLADDLDQGMNGQVTYAINQSLPMTGLYHIDPQTGTITTAAILDREIWSQTRLVVTAMDRGTPPLVGSATLTVVVMDINDNSPTIPFPWEVRVPENMLLGTQIAQLTGNDVDSGPALSYTLVLDGDAVGTFSVLRYGGRIALTGPLDYEQRSHYSLTLRASDTRHETEANLTVIVEDMNDNAPAFSQPFYQVTLPEHTPAGSILLTMSATDMDSGSNGDITFHLAVPSLDVAIDPSNGTLFTIRPVEFDANQPTLELVVEARDRGSPSLSSWATVQLQVLDVNDHSPIFQVPHYNASVPEDLRPGTTVLTLDAGDADLSRENAGFDYTIVSGNSGNAFQVESRVAWAGGQLRTQGALVLVEPLDFEAIPVYNLTVAALDRGLPQRSTTVPVLITVQDVNDNPPVFARAEYRTAVSESTPPGTELLRLTAHDADSGPRGHVHYSISSGDQHGLFQIHESTGALCLARPLDRETQASHALVVQATDVPGGHFALVPVAIEVKDVNDNKPYFPVEVLSASMRENLPPGTLVTTLRAIDTDTGVFGELQYAVLEQPAGGPGVAEGRDAFAINSSSGELRSRLTFDYERAKAFQLLVRATDAGNASATVTVRVLVTGEDEYDPIFLSPSFSFEVPEGAHKGQSIGRVLATDEDEGADGVVLYSLAKPSPYFAINQTTGTIYLRVDSQPQAGAGRTKREPREMSFEVQARSPLPASRSASAQVTIDVTHTSFGLAPDLNLLLVAVAASLGVVVVLAAVAIVLALVRSRHRRGHEKTEGDRPLAHVQSSSLQKLGHEEPALPGAEHIYHQALPGYGGEPAGPYTRGGSLDPSHSSGRGSAEAAEDDEIRMINEYPRVASITASMQEHISARGPDSGIQQDADQLSDISCEPAALESSQWFKSKKGSGLLLPGPTSQLYREDGGGSAFLGVRCGLSVSSQPQDYTFPEDGKPSVEGSLTAIVASDEELRGSYNWDYLLNWCPQFQPLASVFTEIARLKDESSLRKPFPTKPKAEPKPRIDPPPLITSVAHPGAKSVPPKPPAGRTFPHPSSLRRSPISHEGSISSSAMSPSFSPSLSPLAARSPVVSPFGISQGPSASTISAEHSLEPSEEAELRI", "length": 3266 }, "evidence": [ { "id": "E1B969", "url": "https://omabrowser.org/oma/group/E1B969/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4ACX8-1", "protein_name": "Protocadherin-16", "gene_name": "Dchs1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQEELSVALSCPGMKSLGTLLPLLVLLGTTVPGIRGQAGSLDLQIDEEQPAGTLIGDISAGLPPGTAPPPMYFISAQEGSGVGTDLDIDEHSGVVCTARVLDRERRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQARAALQIPEHTALGTRYPLEPAHDADAGRLGTQGYALSGDGAGETFRLETRPGPGGAPVPELVIAGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGANGAVTYEINRRQSEGDGPFSIDAHTGFLKLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPRVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDVYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGTHTHWFSIDPTSGIITTAATLDYELEPQPQLIVVATDGGLPPLVSSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGASGSPPFRIDAHSGEVCTTRILDRDQGPSSFDFTVTAIDGGGLKSMVYVKVFVADENDNPPQFYPREYAASLSAQSTPGTAVLRVHAHDPDQGPHGRLSYHILAGNSPPLFALDAHSGLLTVAWPLGRRANSVVQLEIGAQDGGGLQAEPIARVNISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGVVQAHNPPGRLGPVTLTLSGGDPRGLFSLDSASGLLKTLRPLDRELLGPVLELEVRAGSGTPPVFSAARIRVLLDDVNDNSPAFPAPEDTVLLPQNTAPGTPVYTLRALDPDSGANSRVTFSLLAGGDGLFTVDPTTGHVRLMGPLGPPGGPPHELEVEAQDGGSPPRTSHFRLRVVIQDLGIHGLAPRFDSPTYRVDLPSGTTTGTQILQVQAQAPDGSPVTYHLAADGASNPFGLESQSGWLWVRAALDRESQELYTLKVMAVSGSKAELGQQTGTATVRVVILNQNDHSPRLSEEPTFLAVAENQPPGTSVGRVFATDKDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSFQLLVQVQDAGSPPRSATGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGSGSELFSLHPHTGELHTAASLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSTRMVESPDLVEADSAATVPVVLTVTAAEGLRPGSLLGSVAPQEPASMGVLTYTLVGGADPEGTFALDSASGRLYLARVLDFESGPAWRALTVRAEGPGGAGARLMRVQVRVQDENEHAPAFARDPLALALPENPEPGATLYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLIVEATDRPANASRRKATRVSARVFVTDENDNAPVFASPSRMRLPEDQPPGPAALHVVARDPDLGEAARVSYRLAAGGDGHFRLHATTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSSTQLLTVSVVDVNDEAPAFPQQEYNVILRENSPPGTSLLTLKATDPDLGANGQVTYGGVSGESFSLDPNSGVLTTLRALDREEQEEINLTVYARDRGLPPLLTHITVRVTVEDENDHSPTFGNTHLSLEVPEGQDPQTLTTLRASDPDGGLNGQLQYRILGGDPSGAFALDLTSGEFGTTRPLDREVEPAFQLQIEARDGGQPALSATLLVTVTVLDANDHAPAFPVPSYSVEVPEDAPVGTLLLQLQAHDPDEGDNGRVMYYLGAGTAGAFLLEPTSGELSTATALDREHCASYAFSVTAVDGAAAGPLSTTVPITVTVRDVNDHAPAFPTSPLRLRLPRPGPSLNKPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPAALGPRDRVLFIVATDLGRPARSATGVVIVGIQGEPERGPRFPRANNEAVLRENAPPGTPVISPKAVHSGGSNGPITYSILSGNERGIFSIQPSTGTITVQSAEGLDFETNPRLRLVLQAESGGAFAFSVLTLTLQDANDNAPRFLQPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPATGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSIGRYGGRVSLTGPLDFEQCDHYHLQLLAHDGPHEGHANLTVLVEDVNDNVPIFSQSLYQVMMLEHTPPGSAILSVSATDRDSGANGHISYHLASPAEGFSVDTNNGTLFTTVGAMALGHEGPGVVDVVLEARDHGAPGRSAQATVHVQLKDQNDHAPSFTLPHYRVAVSEDLPPGSTLLTLEAIDADGSRSHATVDYSIISGNRGRVFQLEPRLAEVGDGVGPGPQALGCLVLLEPLDFESLTQYNLTVTAADRGQPPRSSAVPVTVTVLDVNDNPPVFTRASYRVTVPEDMPVGAELLHVEASDADPGPHGLVHFTLSSGDPLGLFELDENSGALRLAHPLDCETQAQHQLVVQAADPAGTHFALVPVTVEVQDVNDHGPAFPLSLLSTSLAENQPPGTLVTTLHAMDGDAGTFGRLRYTLLEAVPGPEGREAFSLNSSTGELRARVPFDYEHTGSFRLLVGAADAGNLSASVTVSVLITGEDEYDPVFLAPSFHFQVPEGAQRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSGTATSGGGGRTRREAPRELRLEVVARGPLPGSRSATVPVTVDITHTALGLAPDLNLLLVGAVAASLGVVVVLALAALVLGLVRARSRKAEAAPGPMSQTAPIASSSLQKLGREPPSPPPSEHLYHQTLPSYGGPGAGGPYPRGGSLDPSHSSGRGSAEAAEDDEIRMINEFPRVASVASSLAARGPDSGIQQDADGLSDTSCEPPAPDTWYKGRKAGLLLPGAGATLYREEGPPATATAFLGGCGLSPAPTGDYGFPADGKPCVAGALTAIVAGEEELRGSYNWDYLLSWCPQFQPLASVFTEIARLKDEARPCPPAPRIDPPPLITAVAHPGAKSVPPKPASTAATRAIFPPASHRSPISHEGSLSSAAMSPSFSPSLSPLAARSPVVSPFGVAQGPSASALSTESGLEPPDDTELRI", "length": 3291 }, "evidence": [ { "id": "E1B969", "url": "https://omabrowser.org/oma/group/E1B969/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9PVD3-1", "protein_name": "Protocadherin-16", "gene_name": "Dchs1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQKELSVALSCPGMKSLRTLLPLLVLLGATVPGSWGQAGSLDLQIDEEQPAGTLIGDISAGLPPGTAPPPMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDRERRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQARAALQIPEHTALGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPGGAPVPELVIAGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGANGAVTYEINRRQSEGDGPFSIDAHTGFLRLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPRVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDVYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQITYSLAPGTHTHWFSIDPTSGIITTAATLDYELEPQPQLIVVATDGGLPPLVSSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGASGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAIDGGGLKSMVYVKVFVADENDNPPQFYPREYAASLSAQSTPGTAVLRVHAHDPDQGPHGRLSYHILAGNSPPLFALDAHSGLLTVAWPLGRRANSVVQLEIGAQDGGGLQAEPIARVNISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIIQAHNPPGRLGPVTLTLSGGDPRGLFSLDSPSGLLKTLRPLDRELLGPVLELEVRAGSGTPPVFAVARIRVLLDDVNDNSPAFPAPEDTVLLPQNTAPGTPIYTLRALDPDSGANSRITFNLLAGGDGLFTVDPTTGHVRLMGPLGPPGGPAHELEVEARDGGSPPRTSHFRLRVVIQDLGIHGLAPRFDSPTYRVDLPSGTTTGTQILQVQAQAPDGSPVTYHLAADGASSPFGLESQSGWLWVRTALDRESQELYTLKVMAVSGSKAELGQQTGTATVRVIILNQNDHSPRLSEEPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSFQLLVQVQDGGSPPRSATGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHTGELHTAASLVRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSTRVVESPDLIEADSAATVPVVLTVTAAEGLRPGSLLGSVAPQEPASVGVLTYTLVGGADPEGTFALDSASGRLYLARPLDFEAGPAWRALTVRAEGPGGAGARLLRVQVRVQDENEHAPTFARDPLALALPENPDPGATLYTFRASDADGPGPNSEVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLAAGGDGHFRLHATTGALSVVRPLDREQRAEHVLTVVALDHGSPPRSSTQLLTVSVVDVNDEAPAFPQQEYNVILRENSPPGTSLLTLKATDPDLGANGQVTYGGVSGESFSLDPNTGVLTTLRALDREEQEEIYLTVYARDRGLPPLLTHITVRVTVEDENDHTPTFGNTHLSLEVPEGQDPQTLTTLRASDPDGGLNGQLQYRILDGDSSGAFALDLTSGEFGTMRPLDREVEPAFQLQIEARDGGQPALSATLLVTVTVLDANDHAPVFPVPSYSVEVPEDAPVGTLLLQLQAHDPDDGDNGRVMYYLGAGTAGAFLLEPTSGELSTATALDREHCASYAFSVTAVDGAAAGPLSTTVPITITVRDVNDHAPAFPTSPLRLRLPRPGPSLNKPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPQDRVLFIVATDLGRPARSATGVVVVGIQGEPERGPRFPRTSSEAVLRENAPPGTPVISPKAVHSGGSNGPITYSILSGNERGIFSIQPSTGAITVRSAEGLDFETSPRLRLVLQAESGGAFAFSVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPATGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSIGRYGGRVSLTGPLDFEQCDHYHLQLLAHDGPHEGHANLTVLVEDVNDNVPTFSQSLYQVMMLEHTPPGSAILSVSATDRDSGANGHISYHLASPAEGFRVDPNNGTLFTTVGAMALGHEGPGVVDVVLEARDHGAPGRTAQATVHVQLKDQNDHAPSFTLPHYRVAVSEDLPPGSTLLTLEATDADGSRTHATVDYSIISGNRGRVFQLEPRLAEVGDGVGPGPQALGCLVLLEPLDFESLTQYNLTVAAADRGQPPRSSAVPVTVTVLDVNDNPPVFTRASYRVTVPEDMPVGAELLHVEASDADPGPHGLVHFTLSSGDPLGLFELDENSGALRLSRPLDCETQAQHQLVVQAADPAGTHFSLVPVTVEVQDVNDHGPAFPLSLLSTSLAENQPPGTLVTTLHAIDGDAGTFGRLRYSLLEAVPGPEGREAFSLNSSTGELRARVPFDYEHTGSFRLLVGAADAGNLSASVTVSVLITGEDEYDPVFLAPSFHFQVPEGAQRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSGTTTSGGGGRTRREAPRELRLEVVARGPLPGSRSATVPVTVDITHTALGLAPDLNLLLVGAVAASLGVVVVLALAALVLGLVRARSRKAEAAPGPMSQTAPIASSSLQKLGREPPSPPPSEHLYHQTLPSYGGPGAGGPYPRGGSLDPSHSSGRGSAEAAEDDEIRMINEFPRVASVASSLAARGPDSGIQQDADGLSDTSCEPPAPDTWYKGRKAGLLLPGAGATLYREEGPPATATAFLGGCGLSPAPAGDYGFPADGKPCVAGALTAIVAGEEELRGSYNWDYLLSWCPQFQPLASVFTEIARLKDEARPCPPAPRIDPPPLITAVAHPGAKSVPPKPASTAVARAIFPPASHRSPISHEGSLSSAAMSPSFSPSLSPLAARSPVVSPFGVAQGPSASALSTESGLEPPDDTELRI", "length": 3291 }, "evidence": [ { "id": "E1B969", "url": "https://omabrowser.org/oma/group/E1B969/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96JQ0-1", "protein_name": "Protocadherin-16", "gene_name": "DCHS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQKELGIVPSCPGMKSPRPHLLLPLLLLLLLLLGAGVPGAWGQAGSLDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSGTATSGGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTVDITHTALGLAPDLNLLLVGAVAASLGVVVVLALAALVLGLVRARSRKAEAAPGPMSQAAPLASDSLQKLGREPPSPPPSEHLYHQTLPSYGGPGAGGPYPRGGSLDPSHSSGRGSAEAAEDDEIRMINEFPRVASVASSLAARGPDSGIQQDADGLSDTSCEPPAPDTWYKGRKAGLLLPGAGATLYREEGPPATATAFLGGCGLSPAPTGDYGFPADGKPCVAGALTAIVAGEEELRGSYNWDYLLSWCPQFQPLASVFTEIARLKDEARPCPPAPRIDPPPLITAVAHPGAKSVPPKPANTAAARAIFPPASHRSPISHEGSLSSAAMSPSFSPSLSPLAARSPVVSPFGVAQGPSASALSAESGLEPPDDTELHI", "length": 3298 }, "evidence": [ { "id": "E1B969", "url": "https://omabrowser.org/oma/group/E1B969/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "mitral valve formation", "id": "GO:0003192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003192", "evidence": [ { "database": "UniProtKB", "id": "E1B969", "url": "https://www.uniprot.org/uniprotkb/E1B969" } ], "pmid": "" }, { "name": "hippo signaling", "id": "GO:0035329", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035329", "evidence": [ { "database": "UniProtKB", "id": "E1B969", "url": "https://www.uniprot.org/uniprotkb/E1B969" } ], "pmid": "" }, { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "E1B969", "url": "https://www.uniprot.org/uniprotkb/E1B969" } ], "pmid": "" }, { "name": "heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "id": "GO:0007157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007157", "evidence": [ { "database": "UniProtKB", "id": "E1B969", "url": "https://www.uniprot.org/uniprotkb/E1B969" } ], "pmid": "" }, { "name": "neurogenesis", "id": "GO:0022008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022008", "evidence": [ { "database": "UniProtKB", "id": "E1B969", "url": "https://www.uniprot.org/uniprotkb/E1B969" } ], "pmid": "" }, { "name": "cell migration involved in endocardial cushion formation", "id": "GO:0003273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003273", "evidence": [ { "database": "UniProtKB", "id": "E1B969", "url": "https://www.uniprot.org/uniprotkb/E1B969" } ], "pmid": "" }, { "name": "tissue morphogenesis", "id": "GO:0048729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048729", "evidence": [ { "database": "UniProtKB", "id": "E1B969", "url": "https://www.uniprot.org/uniprotkb/E1B969" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "E1B969", "url": "https://www.uniprot.org/uniprotkb/E1B969" } ], "pmid": "" }, { "name": "heart morphogenesis", "id": "GO:0003007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003007", "evidence": [ { "database": "UniProtKB", "id": "E1B969", "url": "https://www.uniprot.org/uniprotkb/E1B969" } ], "pmid": "" }, { "name": "mitral valve morphogenesis", "id": "GO:0003183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003183", "evidence": [ { "database": "UniProtKB", "id": "E1B969", "url": "https://www.uniprot.org/uniprotkb/E1B969" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B969", "url": "https://www.uniprot.org/uniprotkb/E1B969" } ], "pmid": "" }, { "name": "apical part of cell", "id": "GO:0045177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", "evidence": [ { "database": "UniProtKB", "id": "E1B969", "url": "https://www.uniprot.org/uniprotkb/E1B969" } ], "pmid": "" }, { "name": "catenin complex", "id": "GO:0016342", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016342", "evidence": [ { "database": "UniProtKB", "id": "E1B969", "url": "https://www.uniprot.org/uniprotkb/E1B969" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "E1B969", "url": "https://www.uniprot.org/uniprotkb/E1B969" } ], "pmid": "" }, { "name": "cadherin binding", "id": "GO:0045296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045296", "evidence": [ { "database": "UniProtKB", "id": "E1B969", "url": "https://www.uniprot.org/uniprotkb/E1B969" } ], "pmid": "" }, { "name": "beta-catenin binding", "id": "GO:0008013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013", "evidence": [ { "database": "UniProtKB", "id": "E1B969", "url": "https://www.uniprot.org/uniprotkb/E1B969" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1247, "end_pos": 1249, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1519, "end_pos": 1521, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1691, "end_pos": 1693, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1716, "end_pos": 1718, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1994, "end_pos": 1996, "annotation": "n_glycosylation_sequon" }, { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2359, "end_pos": 2361, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2426, "end_pos": 2428, "annotation": "n_glycosylation_sequon" }, { 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"https://www.ncbi.nlm.nih.gov/protein/NP_001180050" } ] }, { "name": "mitochondrial pyruvate carrier 2", "type": "synonym", "evidence": [ { "id": "NP_001180050", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180050" } ] } ], "function": [ { "annotation": "Mediates the uptake of pyruvate into mitochondria.", "evidence": [ { "database": "UniProtKB", "id": "E1BD64", "url": "https://www.uniprot.org/uniprotkb/E1BD64#function" }, { "database": "UniProtKB", "id": "RU363100", "url": "https://www.uniprot.org/uniprotkb/RU363100#function" }, { "database": "UniProtKB", "id": "A0AAA9S2D4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2D4#function" }, { "database": "UniProtKB", "id": "A0AAA9TEJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEJ2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BD64", "url": "https://www.uniprot.org/uniprotkb/E1BD64" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MPC2", "url": "https://www.uniprot.org/uniprotkb/E1BD64", "locus": { "chromosome": "3", "start_pos": 794635, "end_pos": 752398, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020968", "url": "https://www.ensembl.org/id/ENSBTAG00000020968" } ] } } ], "crossref": [ { "id": "E1BD64", "url": "https://alphafold.ebi.ac.uk/entry/E1BD64", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020968", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020968", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616718", "url": "https://www.ncbi.nlm.nih.gov/gene/616718", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005336", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005336", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616718", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616718", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PQQFAIC", "url": "https://omabrowser.org/oma/group/PQQFAIC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BD64", "url": "https://www.orthodb.org/?gene=E1BD64", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14154", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14154", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03650", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03650", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001180050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180050", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S2D4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2D4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2D4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2D4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD64", "url": "https://www.uniprot.org/uniprotkb/E1BD64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD64-1", "url": "https://www.uniprot.org/uniprotkb/E1BD64-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAAGVRGLRATYHRVLDKVELLLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGTAGASQLFRIWRYNQELKAKANK", "length": 127, "header": "tr|E1BD64-1|E1BD64_BOVIN Isoform 1 of Mitochondrial pyruvate carrier OS=Bos taurus OX=9913 GN=MPC2 PE=3 SV=2 CANONICAL=E1BD64-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2D4-1", "url": "https://www.uniprot.org/uniprotkb/E1BD64/entry#A0AAA9S2D4-1", "sequence": { "sequence": "MSAAGVRGLRATYHRVLDKVELLLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGTAGASQLFRIWSILYT", "length": 120, "header": "tr|A0AAA9S2D4-1|E1BD64_BOVIN Computationally mapped isoform of Mitochondrial pyruvate carrier OS=Bos taurus OX=9913 GN=MPC2 PE=3 SV=1 CANONICAL=E1BD64-1" }, "locus": { "chromosome": "3", "start_pos": 784241, "end_pos": 753129, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123421.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123421.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076266.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076266.1" } ] } }, { "isoform_ac": "A0AAA9TEJ2-1", "url": "https://www.uniprot.org/uniprotkb/E1BD64/entry#A0AAA9TEJ2-1", "sequence": { "sequence": "MSAAGVRGLRATYHRVLDKVELLLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGTAGASQLFRIWRRPAFDP", "length": 122, "header": "tr|A0AAA9TEJ2-1|E1BD64_BOVIN Computationally mapped isoform of Mitochondrial pyruvate carrier OS=Bos taurus OX=9913 GN=MPC2 PE=3 SV=1 CANONICAL=E1BD64-1" }, "locus": { "chromosome": "3", "start_pos": 794481, "end_pos": 753129, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128828.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128828.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095220.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095220.1" } ] } }, { "isoform_ac": "E1BD64-1", "url": "https://www.uniprot.org/uniprotkb/E1BD64/entry#E1BD64-1", "sequence": { "sequence": "MSAAGVRGLRATYHRVLDKVELLLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGTAGASQLFRIWRYNQELKAKANK", "length": 127, "header": "tr|E1BD64-1|E1BD64_BOVIN Isoform 1 of Mitochondrial pyruvate carrier OS=Bos taurus OX=9913 GN=MPC2 PE=3 SV=2 CANONICAL=E1BD64-1" }, "locus": { "chromosome": "3", "start_pos": 782824, "end_pos": 753129, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027927.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027927.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027927.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027927.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616718", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616718", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1V8M2-1", "protein_name": "Mitochondrial pyruvate carrier", "gene_name": "MPC2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSAAGARGLRATYHRVLDKVELLLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGTAGASQLFRIWRYNQELKAKANK", "length": 127 }, "evidence": [ { "id": "E1BD64", "url": "https://omabrowser.org/oma/group/E1BD64/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7JRV3-1", "protein_name": "Mitochondrial pyruvate carrier", "gene_name": "Mpc2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAAGARGLRASYHRLMDKVELLLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSTVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGSAGASQLFRIWRYNQELKAKGIKSS", "length": 129 }, "evidence": [ { "id": "E1BD64", "url": "https://omabrowser.org/oma/group/E1BD64/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1NU06-1", "protein_name": "Mitochondrial pyruvate carrier", "gene_name": "MPC2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAAVTGLRASYHRLLDRIELMLPPRFRPFYNHPAGPKTVFFWAPIMKWGLVCAGMADMTRPAEKLSTAQSAVLMATGLIWSRYSLVIIPKNWSLFAVNFFVGCAGGSQLFRIWRYNQELKAKQQEQLLQKDA", "length": 133 }, "evidence": [ { "id": "E1BD64", "url": "https://omabrowser.org/oma/group/E1BD64/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O49636-1", "protein_name": "Mitochondrial pyruvate carrier 4", "gene_name": "MPC4", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MATSKLQAIWNHPAGPKTIHFWAPTFKWGISIANIADFAKPPEKLSYPQQIAVTCTGVIWSRYSMVINPKNWNLFSVNVAMAGTGIYQLARKIKHDYATEAEPAVASE", "length": 108 }, "evidence": [ { "id": "E1BD64", "url": "https://omabrowser.org/oma/group/E1BD64/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "O95563-1", "protein_name": "Mitochondrial pyruvate carrier 2", "gene_name": "MPC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSAAGARGLRATYHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELKAKAHK", "length": 127 }, "evidence": [ { "id": "E1BD64", "url": "https://omabrowser.org/oma/group/E1BD64/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P38718-1", "protein_name": "Mitochondrial pyruvate carrier 2", "gene_name": "Mpc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAGARGLRATYHRLMDKVELLLPKKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSTVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGSAGASQLFRIWKYNQELKSKGIQ", "length": 127 }, "evidence": [ { "id": "E1BD64", "url": "https://omabrowser.org/oma/group/E1BD64/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P53311-1", "protein_name": "Mitochondrial pyruvate carrier 3", "gene_name": "MPC3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSASAFNFAFRRFWNSETGPKTVHFWAPTLKWGLVFAGLNDIKRPVEKVSGAQNLSLLATALIWTRWSFVIKPKNYLLASVNFFLGCTAGYHLTRIANFRIRNGDSFKQVIHYIIKGETPAAVAAKQTASTSMNKGVIGTNPPITH", "length": 146 }, "evidence": [ { "id": "E1BD64", "url": "https://omabrowser.org/oma/group/E1BD64/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q9D023-1", "protein_name": "Mitochondrial pyruvate carrier 2", "gene_name": "Mpc2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAGARGLRATYHRLMDKVELLLPKKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSTVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGSAGASQLFRIWRYNQELKSKGIQ", "length": 127 }, "evidence": [ { "id": "E1BD64", "url": "https://omabrowser.org/oma/group/E1BD64/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VHB1-1", "protein_name": "Mitochondrial pyruvate carrier", "gene_name": "Mpc2a", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSSTAVQPPPPVPPPPPSAVPSAGKGIHSKLYNGMIGAADKFVPAKLRPLWMHPAGPKTIFFWAPVFKWGLVAAGLSDLARPADTISVSGCAALAATGIIWSRYSLVIIPKNYSLFAVNLFVGITQVVQLARAYHYHQSQEKLKQEQQQPAVQN", "length": 154 }, "evidence": [ { "id": "E1BD64", "url": "https://omabrowser.org/oma/group/E1BD64/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "E1BD64", "url": "https://www.uniprot.org/uniprotkb/E1BD64" } ], "pmid": "" }, { "name": "mitochondrial pyruvate carrier complex", "id": "GO:7770001", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:7770001", "evidence": [ { "database": "UniProtKB", "id": "E1BD64", "url": "https://www.uniprot.org/uniprotkb/E1BD64" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "pyruvate import into mitochondria", "id": "GO:0006850", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006850", "evidence": [ { "database": "UniProtKB", "id": "E1BD64", "url": "https://www.uniprot.org/uniprotkb/E1BD64" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BD64", "url": "https://www.uniprot.org/uniprotkb/E1BD64" } ], "pmid": "" }, { "name": "pyruvate transmembrane transporter activity", "id": "GO:0050833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050833", "evidence": [ { "database": "UniProtKB", "id": "E1BD64", "url": "https://www.uniprot.org/uniprotkb/E1BD64" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BD64-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 127, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BD64-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BD64" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 93, "end_pos": 95 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"evidence": [ { "database": "UniProtKB", "id": "E1BBI6", "url": "https://www.uniprot.org/uniprotkb/E1BBI6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCNYL1", "url": "https://www.uniprot.org/uniprotkb/E1BBI6", "locus": { "chromosome": "2", "start_pos": 96036085, "end_pos": 95992817, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016297", "url": "https://www.ensembl.org/id/ENSBTAG00000016297" } ] } } ], "crossref": [ { "id": "E1BBI6", "url": "https://alphafold.ebi.ac.uk/entry/E1BBI6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016297", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016297", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20540", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20540", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538167", "url": "https://www.ncbi.nlm.nih.gov/gene/538167", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006671", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006671", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012399", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012399", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538167", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538167", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RWADAYQ", "url": "https://omabrowser.org/oma/group/RWADAYQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBI6", "url": "https://www.orthodb.org/?gene=E1BBI6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14248", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14248", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00134", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00134", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27989", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27989", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003585812", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585812", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S3M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3M2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3M2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3M2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7C9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7C9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7C9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7C9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBI6", "url": "https://www.uniprot.org/uniprotkb/E1BBI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBI6-1", "url": "https://www.uniprot.org/uniprotkb/E1BBI6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNTLTCCVSPSASPKLGRRAGPAEPDYESEVYEAAAGDAVAVAPAPATVEPTELDFGAGEGHHLQHISDREMPEDLALESNPSDHPRASTIFLSKSQTDVREKRKSNHLNHVSPGQLTKKYSSCSTIFLDDSTVSQPNLRTTIKCVTLAIYYHIKNRDANRSLDIFDERSHPLTREKVPEEYFKHDPEHKFIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPTNWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNEMERHFLELLQFNINVPASVYAKYYFDLRSLADDNNLNFLFAPLSKERAQNLEAISRLCEDKYKDLCRVAVRRSFSADNFIGIQRSNAILS", "length": 363, "header": "tr|E1BBI6-1|E1BBI6_BOVIN Isoform 1 of Cyclin Y like 1 OS=Bos taurus OX=9913 GN=CCNYL1 PE=3 SV=1 CANONICAL=E1BBI6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S3M2-1", "url": "https://www.uniprot.org/uniprotkb/E1BBI6/entry#A0AAA9S3M2-1", "sequence": { "sequence": "MGNTLTCCVSPSASPKLGRRAGPAEPDYESEVYEAAAGDAVAVAPAPATVEPTELDFGAGEGHHLQHISDREMPEDLALESNPSDHPRASTIFLSKSQTDVREKRKSNHLNHVSPGQLTKKYSSCSTIFLDDSTVSQPNLRTTIKCVTLAIYYHIKNRDANRSLDIFDERSHPLTREKVPEEYFKHDPEHKFIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPTNWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNEMERHFLELLQFNINVPASVYAKYYFDLRSLADDNNLNFLFAPLSKERAQNLEEQNKNKKLRIKMLWVSFC", "length": 343, "header": "tr|A0AAA9S3M2-1|E1BBI6_BOVIN Computationally mapped isoform of Cyclin Y like 1 OS=Bos taurus OX=9913 GN=CCNYL1 PE=3 SV=1 CANONICAL=E1BBI6-1" }, "locus": { "chromosome": "2", "start_pos": 96035081, "end_pos": 95993016, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095148.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095148.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077864.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077864.1" } ] } }, { "isoform_ac": "A0AAA9T7C9-1", "url": "https://www.uniprot.org/uniprotkb/E1BBI6/entry#A0AAA9T7C9-1", "sequence": { "sequence": "MGNTLTCCVSPSASPKLGRRAGPAEPDYESEVYEAAAGDAVAVAPAPATVEPTELDFGAGEGHHLQHISDREMPEDLALESNPSDHPRASTIFLSKSQTDVREKRKSNHLNHCDLSNILPHKEQREKVPEEYFKHDPEHKFIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPTNWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNEMERHFLELLQFNINVPASVYAKYYFDLRSLADDNNLNFLFAPLSKERAQNLEAISRLCEDKYKDLCRVAVRRSFSADNFIGIQRSNAILS", "length": 312, "header": "tr|A0AAA9T7C9-1|E1BBI6_BOVIN Computationally mapped isoform of Cyclin Y like 1 OS=Bos taurus OX=9913 GN=CCNYL1 PE=3 SV=1 CANONICAL=E1BBI6-1" }, "locus": { "chromosome": "2", "start_pos": 96027479, "end_pos": 95993016, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134221.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134221.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092512.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092512.1" } ] } }, { "isoform_ac": "E1BBI6-1", "url": "https://www.uniprot.org/uniprotkb/E1BBI6/entry#E1BBI6-1", "sequence": { "sequence": "MGNTLTCCVSPSASPKLGRRAGPAEPDYESEVYEAAAGDAVAVAPAPATVEPTELDFGAGEGHHLQHISDREMPEDLALESNPSDHPRASTIFLSKSQTDVREKRKSNHLNHVSPGQLTKKYSSCSTIFLDDSTVSQPNLRTTIKCVTLAIYYHIKNRDANRSLDIFDERSHPLTREKVPEEYFKHDPEHKFIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPTNWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNEMERHFLELLQFNINVPASVYAKYYFDLRSLADDNNLNFLFAPLSKERAQNLEAISRLCEDKYKDLCRVAVRRSFSADNFIGIQRSNAILS", "length": 363, "header": "tr|E1BBI6-1|E1BBI6_BOVIN Isoform 1 of Cyclin Y like 1 OS=Bos taurus OX=9913 GN=CCNYL1 PE=3 SV=1 CANONICAL=E1BBI6-1" }, "locus": { "chromosome": "2", "start_pos": 96027479, "end_pos": 95993016, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038209.6", "url": "https://www.ensembl.org/id/ENSBTAT00000038209.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038024.3", "url": "https://www.ensembl.org/id/ENSBTAP00000038024.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538167", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538167", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LYE0-1", "protein_name": "Cyclin Y-like 1", "gene_name": "Ccnyl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPEDLALESNPSDHPRASTIFLSKSQTDVREKRKSNHLNHVSPGQLTKKYSSCSTIFLDDSTVSQPNLRTTIKCVTLAIYYHIKNRDANRSLDIFDERSHPLTREKVPEEYFKHDPEHKFIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPTNWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNEMERHFLELLQFNINVPASVYAKYYFDLRSLADDNNLNFLFAPLSKERAQNLEAISRLCEDKYKDLCRAAMRRSLSADNFIGIQRSNAILS", "length": 291 }, "evidence": [ { "id": "E1BBI6", "url": "https://omabrowser.org/oma/group/E1BBI6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3YUJ3-1", "protein_name": "Cyclin-Y-like protein 1", "gene_name": "Ccnyl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METRIRAAQLKGRGGAFPKLGRRAGPAEPDYESEVYEAAAGDAVAVAPAPAAAVEPAELDFGAGEGHHLQHISDREMPEDLALESNPSDHPRASTIFLSKSQTDVREKRKSNHLNHVSPGQLTKKYSSCSTIFLDDSTVSQPNLRTTIKCVTLAIYYHIKNRDANRSLDIFDERSHPLTREKVPEEYFKHDPEHKFIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPTNWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNEMERHFLELLQFNINVPASVYAKYYFDLRSLADDNNLNFLFAPLSKERAQNLEAISRLCEDKYKDLCRAAMRRSLSADNFIGIQRSNAILS", "length": 367 }, "evidence": [ { "id": "E1BBI6", "url": "https://omabrowser.org/oma/group/E1BBI6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "I3L5S3-1", "protein_name": "Cyclin Y like 1", "gene_name": "CCNYL1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGNTLSCCLSPNASPKLGRRKGPVEPDYESEVCEAAAGDAVAVASAPAAVEPAELDYGAGEGHHLQHISDREMPEDLAFESNPSDHPRASTIFLSKSQTDVREKRKSNHLNHVSPGQLTKKYSSCSTIFLDDSTVSQPNLRTTIKCVTLAIYYHIKNRDADRSLDIFDERSHPLTREKVPEEYFKHDPEHKFIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPTNWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNEMERHFLELLQFNINVPSSVYAKYYFDLRSLADDNNVNFLFAPLSKERAQNLEAISRLCEDKYKDLCRAAMRRSFSADNFIGIQRSNAILS", "length": 363 }, "evidence": [ { "id": "E1BBI6", "url": "https://omabrowser.org/oma/group/E1BBI6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q08CI4-1", "protein_name": "Cyclin-Y-like protein 1", "gene_name": "ccnyl1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGNTVSCCVSPSGSPKLPRQVERLEDYQNNTDISDDTGPYLQHISDREVPDDLALESNPSDHARASTIFLSKSQTDVRDRRKSNHINHVSPGLLSKKYSSCSTIFIDDSTVSQPNLKSTIKCVTLAIYYHIKNRDSDRSLDIFDEKMHPLSREQVPDDYSRTDPEHKLIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAELDICPSNWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNEMERHFLELLQFNINVPASVYAKYYFDLRSLADDNNLSFPLEPLSNERAQKLEAISRLCEDKYKDLSRVAMRRSFSADNLVGIRRSNAVLS", "length": 339 }, "evidence": [ { "id": "E1BBI6", "url": "https://omabrowser.org/oma/group/E1BBI6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8N7R7-1", "protein_name": "Cyclin-Y-like protein 1", "gene_name": "CCNYL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGNTLTCCVSPNASPKLGRRAGSAELYCASDIYEAVSGDAVAVAPAVVEPAELDFGEGEGHHLQHISDREMPEDLALESNPSDHPRASTIFLSKSQTDVREKRKSNHLNHVSPGQLTKKYSSCSTIFLDDSTVSQPNLRTTVKCVTLAIYYHIKNRDANRSLDIFDERSHPLTREKVPEEYFKHDPEHKFIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPTNWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNEMERHFLELLQFNINVPASVYAKYYFDLRSLADDNNLNFLFAPLSKERAQNLEAISRLCEDKDLCRAAMRRSFSADNFIGIQRSKAILS", "length": 359 }, "evidence": [ { "id": "E1BBI6", "url": "https://omabrowser.org/oma/group/E1BBI6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "E1BBI6", "url": "https://www.uniprot.org/uniprotkb/E1BBI6" } ], "pmid": "" }, { "name": "cyclin-dependent protein serine/threonine kinase activator activity", "id": "GO:0061575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061575", "evidence": [ { "database": "UniProtKB", "id": "E1BBI6", "url": "https://www.uniprot.org/uniprotkb/E1BBI6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BBI6", "url": "https://www.uniprot.org/uniprotkb/E1BBI6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of canonical Wnt signaling pathway", "id": "GO:0060828", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060828", "evidence": [ { "database": "UniProtKB", "id": "E1BBI6", "url": "https://www.uniprot.org/uniprotkb/E1BBI6" } ], "pmid": "" }, { "name": "neurogenesis", "id": "GO:0022008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022008", "evidence": [ { "database": "UniProtKB", "id": "E1BBI6", "url": "https://www.uniprot.org/uniprotkb/E1BBI6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBI6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 363, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBI6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBI6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBI6" }, { "id": "SM00385", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00385" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cyclin-like", "eco_id": "ECO_0000259", "start_pos": 195, "end_pos": 280, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 161, "end_pos": 163 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A7Z026-1", "uniprot_ac": "A7Z026", "uniprot_id": "PPR37_BOVIN", "mass": { "chemical_mass": 75697.0, "monoisotopic_mass": 75697.0 }, "refseq": { "ac": "NP_001098849", "name": "protein phosphatase 1 regulatory subunit 37", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098849" }, "gene_names": [ { "name": "PPP1R37", "type": "recommended", "evidence": [ { "id": "A7Z026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z026" } ] }, { "name": "LRRC68", "type": "synonym", "evidence": [ { "id": "NP_001098849", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098849" }, { "id": "A7Z026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z026" } ] }, { "name": "PPP1R37", "type": "synonym", "evidence": [ { "id": "NP_001098849", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098849" } ] } ], "protein_names": [ { "name": "Protein phosphatase 1 regulatory subunit 37", "type": "recommended", "evidence": [ { "id": "A7Z026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z026/entry#names_and_taxonomy" } ] }, { "name": "Leucine-rich repeat-containing protein 68", "type": "synonym", "evidence": [ { "id": "A7Z026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z026/entry#names_and_taxonomy" } ] }, { "name": "leucine rich repeat containing 68", "type": "synonym", "evidence": [ { "id": "NP_001098849", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098849" } ] }, { "name": "leucine-rich repeat-containing protein 68", "type": "synonym", "evidence": [ { "id": "NP_001098849", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098849" } ] }, { "name": "protein phosphatase 1 regulatory subunit 37", "type": "synonym", "evidence": [ { "id": "NP_001098849", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098849" } ] } ], "function": [ { "annotation": "Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.", "evidence": [ { "database": "UniProtKB", "id": "A7Z026", "url": "https://www.uniprot.org/uniprotkb/A7Z026#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7Z026", "url": "https://www.uniprot.org/uniprotkb/A7Z026" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPP1R37", "url": "https://www.uniprot.org/uniprotkb/A7Z026", "locus": { "chromosome": "18", "start_pos": 52802815, "end_pos": 52764965, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018834", "url": "https://www.ensembl.org/id/ENSBTAG00000018834" } ] } } ], "crossref": [ { "id": "A7Z026", "url": "https://alphafold.ebi.ac.uk/entry/A7Z026", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018834", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018834", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00116", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00116", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "516932", "url": "https://www.ncbi.nlm.nih.gov/gene/516932", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051279", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051279", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516932", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516932", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EHELRCP", "url": "https://omabrowser.org/oma/group/EHELRCP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A7Z026", "url": "https://www.orthodb.org/?gene=A7Z026", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24112", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24112", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24112:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24112:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001098849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098849", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S3U5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3U5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7Z026", "url": "https://www.uniprot.org/uniprotkb/A7Z026", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7Z026-1", "url": "https://www.uniprot.org/uniprotkb/A7Z026-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEIPPQEAPPGPGADGEAEEAPVEAPSPGPASPPADGRLKAAAKRVTFPSDEDIVSGAVEPKDPWRHAQNVTVDEIIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRIDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDEDGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLESSSLSGRPLMLLATALKMNMTLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLATLVLWNNQLTHTGMAFLGMTLPHTHSLETLNLGHNPIGNEGVRNLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNFVLVREREEKEQRLQLSASMPEITVTEPQPDDEPREEPAAEAQENGAPGPSPGPDSDSDSDSEGEDRDEADGERAEAPCPTLVPPTDSLGPGDRSPPGCPSSPAEQRISVSSPGWGHKVFVVTRVESPPERAEPPVPPAPPGPVSPPASASPPTSPFPTPTEAASTPDPGPPEPQPPLEPPQVGPPLPNGLKPEFALALSPEPPPGPEAKVGSCGLEHELSCSKNEKELEELLLEASQESGQETL", "length": 699, "header": "sp|A7Z026-1|PPR37_BOVIN Isoform 1 of Protein phosphatase 1 regulatory subunit 37 OS=Bos taurus OX=9913 GN=PPP1R37 PE=2 SV=1 CANONICAL=A7Z026-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S3U5-1", "url": "https://www.uniprot.org/uniprotkb/A7Z026/entry#A0AAA9S3U5-1", "sequence": { "sequence": "MEIPPQEAPPGPGADGEAEEAPVEAPSPGPASPPADGRLKAAAKRVTFPSDEDIVSGAVEPKDPWRHAQNVTVDEIIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRIDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDEDGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLESSSLSGRPLMLLATALKMNMTLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLATLVLWNNQLTHTGMAFLGMTLYSKQAHRVQGLRPRLRITHSQACAQSPQEAGKPHTHSLETLNLGHNPIGNEGVRNLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNFVLVREREEKEQRLQLSASMPEITVTEPQPDDEPREEPAAEAQENGAPGPSPGPDSDSDSDSEGEDRDEADGERAEAPCPTLVPPTDSLGPGDRSPPGCPSSPAEQRISVSSPGWGHKVFVVTRVESPPERAEPPVPPAPPGPVSPPASASPPTSPFPTPTEAASTPDPGPPEPQPPLEPPQVGPPLPNGLKPEFALALSPEPPPGPEAKVGSCGLEHELSCSKNEKELEELLLEASQESGQETL", "length": 731, "header": "tr|A0AAA9S3U5-1|PPR37_BOVIN Computationally mapped isoform of Protein phosphatase 1 regulatory subunit 37 OS=Bos taurus OX=9913 GN=PPP1R37 PE=2 SV=1 CANONICAL=A7Z026-1" }, "locus": { "chromosome": "18", "start_pos": 52801955, "end_pos": 52765113, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088789.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088789.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076780.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076780.1" } ] } }, { "isoform_ac": "A7Z026-1", "url": "https://www.uniprot.org/uniprotkb/A7Z026/entry#A7Z026-1", "sequence": { "sequence": "MEIPPQEAPPGPGADGEAEEAPVEAPSPGPASPPADGRLKAAAKRVTFPSDEDIVSGAVEPKDPWRHAQNVTVDEIIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRIDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDEDGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLESSSLSGRPLMLLATALKMNMTLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLATLVLWNNQLTHTGMAFLGMTLPHTHSLETLNLGHNPIGNEGVRNLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNFVLVREREEKEQRLQLSASMPEITVTEPQPDDEPREEPAAEAQENGAPGPSPGPDSDSDSDSEGEDRDEADGERAEAPCPTLVPPTDSLGPGDRSPPGCPSSPAEQRISVSSPGWGHKVFVVTRVESPPERAEPPVPPAPPGPVSPPASASPPTSPFPTPTEAASTPDPGPPEPQPPLEPPQVGPPLPNGLKPEFALALSPEPPPGPEAKVGSCGLEHELSCSKNEKELEELLLEASQESGQETL", "length": 699, "header": "sp|A7Z026-1|PPR37_BOVIN Isoform 1 of Protein phosphatase 1 regulatory subunit 37 OS=Bos taurus OX=9913 GN=PPP1R37 PE=2 SV=1 CANONICAL=A7Z026-1" }, "locus": { "chromosome": "18", "start_pos": 52801955, "end_pos": 52765113, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025071.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025071.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025071.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025071.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 613, "start_aa": "Thr", "end_pos": 613, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr613", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [ { "start_pos": 50, "end_pos": 50, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7Z026", "url": "https://www.uniprot.org/uniprotkb/A7Z026" } ], "site_lbl": "Ser50" }, { "start_pos": 566, "end_pos": 566, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7Z026", "url": "https://www.uniprot.org/uniprotkb/A7Z026" } ], "site_lbl": "Ser566" }, { "start_pos": 56, "end_pos": 56, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7Z026", "url": "https://www.uniprot.org/uniprotkb/A7Z026" } ], "site_lbl": "Ser56" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:516932", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516932", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B2RYF1-1", "protein_name": "Protein phosphatase 1 regulatory subunit 37", "gene_name": "Ppp1r37", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEIPPQEAPPGPGADADADAEAEEAPAEAGSSSGASPPTDGRLKAAAKRVTFPSDEDIVSGAVEPKDPWRHAQNVTVDEVISAYRQACQKLNCRQIPKLLRQLQEFTDLEQRINCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDEDGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLQELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMALPHTQSLETLNLGHNPIGNEGVRNLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEPVKSFIETQKALLAEIQNGCKRNFVLVREREEKQQLQPSASMPEITITAPQPLEESGDLPAMGAQNGTPGPGPGPDSDSDSDSDREEQEEEEEDQSDQQRDEGGTDQSSSAPCPALLPSTDSLGPGDKSPPGSPSSPTEQRISVSSPGRGHKVFVVTRVESPPERPEPPVPPTSVSSPPPSPPSPPASPPSQTMDTQDPESSEAQPQTEPSQAGQPLPNGLKPEFALALAPEAPPGLEAKGSSCSLEHALHRSHGVSKLEELLLEASQEAPRDTL", "length": 710 }, "evidence": [ { "id": "A7Z026", "url": "https://omabrowser.org/oma/group/A7Z026/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O75864-1", "protein_name": "Protein phosphatase 1 regulatory subunit 37", "gene_name": "PPP1R37", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVEPKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDEDGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETPCPALVPPTDSLGPGDRSPPGSPSTPTEQRISVSSPGRGHKVFVVTRVESPPERAEPPASPTPPSPPPPPSPPASPSLPPAGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHELSCSKNEKELEELLLEASQESGQETL", "length": 691 }, "evidence": [ { "id": "A7Z026", "url": "https://omabrowser.org/oma/group/A7Z026/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q1L994-1", "protein_name": "Protein phosphatase 1 regulatory subunit 37", "gene_name": "ppp1r37", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNCEDQAVDLCKAIDLCNVSDNTISHPTPAEEILPRDGLQLMDGDQEEQDAAVLTRLKDVHLKDDALHTKNNGSIAVSADPVNGSAGDLQQSTVEEPLATKCSVGDVGDDGEMDIGVDLSLDENGVLEFEPTAQTQSEESASSCENSLISDTVIELHSQEPLEEHSVDVPSETVPAAATPVVEEAGIKHGLKRVTFPSDEDIVSGAVEPKDPWRHAQNVTVEEILNAYRQACQKLNCKPIPKVLKQTQDLKDLTQRNECLDLKGEKLDYKSCESLEEIFKRVQFKLVDLEQTNLDEDGASALFDMIEYYESATHLNISNNKHIGTRGWQAAAHMMRKTNSLQYLDARNTPLLDHSAPFVARALRISSSLTVLHLENSGISGRPLMLLATALKMNMNLRELYLAENKLNGLQDSAQLGNLLKFNYNIQILDLRNNHILDSGLAYVCEGLKEQRKGLVTLVLWNNQLTHNGMGYLAAALPFTQSLETLNLGHNAVGNEGVHKLKDGLISNRSILRLGLASTKLSCEGAVAIAEFIAESPRLLRLDMRENEIKTGGLMALSLAFKVNTSLLRLDLDREPKKETVKSFIETQRALLADIQNGCKRNFILAREKEETEQKMRLSASMAEIATEDQTHEEEEEEEASPLKKIEEETTDALKDATQESSEVSENQEPKDQESTPQDDSDSDTEDEETPTNTSLTSTSPIPIPAAADTSKTIPSTPPIASPAVISGITVTEASIVTPSSPGRCISVSSPGRGHKIFMVTRVESPPEQQQTSIAMLKSIQPSAITDIKAPSQTQNSTQPTEKSHAEKTPDAQQEDSVSTSTPSLDANIDQTQLTESVSEEEQKKAETLNNEADINEDANTGAPLPNGLKPEFALFEFEGAKPASCIMEHVSVTAELSCGQDLEELLLDASLETSRDAP", "length": 919 }, "evidence": [ { "id": "A7Z026", "url": "https://omabrowser.org/oma/group/A7Z026/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8BKR5-1", "protein_name": "Protein phosphatase 1 regulatory subunit 37", "gene_name": "Ppp1r37", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEIPPQEAPPGPGADADADAEAETEEASAEAESPTGTSPPADGRLKAAAKRVTFPSDEDIVSGAVEPKDPWRHAQNVTVDEVISAYRQACQKLNCRQIPKLLRQLQEFTDLEQRINCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDEDGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMALPHTQSLETLNLGHNPIGNEGVRNLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEPVKSFIETQKALLAEIQNGCKRNFVLVREREEKQQLQLSASMPEITITAPQPLEESGELPAVGSQNGAPRPGPGPDSDSDSDSDREEQEEEEEDQRNQQRDEGGNDQSSLASCPALIPSTDSLGPGDKSPPSSPSSPTEQRISVSSPGRGHKVFVVTRVESPPERPEPPVPPTFVSSPPPSPPSPPASPPSQTMDTQDPESSEAQPQLEPSQAGQPLPNGLKPEFALALPPEPPPGLEAKGGSCSLEHALHRSQGVSKLEELLLEASQEAPRDTL", "length": 712 }, "evidence": [ { "id": "A7Z026", "url": "https://omabrowser.org/oma/group/A7Z026/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein phosphatase inhibitor activity", "id": "GO:0004864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004864", "evidence": [ { "database": "UniProtKB", "id": "A7Z026", "url": "https://www.uniprot.org/uniprotkb/A7Z026" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 168, "end_pos": 170, "annotation": "n_glycosylation_sequon" }, { "start_pos": 246, "end_pos": 248, "annotation": "n_glycosylation_sequon" }, { "start_pos": 275, "end_pos": 277, "annotation": "n_glycosylation_sequon" }, { "start_pos": 360, "end_pos": 362, "annotation": "n_glycosylation_sequon" }, { "start_pos": 416, "end_pos": 418, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7Z026-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 699, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7Z026-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7Z026" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 613 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 50, 56, 566 ], "sequon_annotation_sites": [ { "start_pos": 168, "end_pos": 170 }, { "start_pos": 246, "end_pos": 248 }, { "start_pos": 275, "end_pos": 277 }, { "start_pos": 360, "end_pos": 362 }, { "start_pos": 416, "end_pos": 418 }, { "start_pos": 70, "end_pos": 72 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BBF8-1", "uniprot_ac": "E1BBF8", "uniprot_id": "E1BBF8_BOVIN", "mass": { "chemical_mass": 45992.0, "monoisotopic_mass": 45992.0 }, "refseq": { "ac": "NP_001179596", "name": "protein fuzzy homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179596" }, "gene_names": [ { "name": "FUZ", "type": "recommended", "evidence": [ { "id": "E1BBF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBF8" } ] }, { "name": "FUZ", "type": "synonym", "evidence": [ { "id": "NP_001179596", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179596" } ] } ], "protein_names": [ { "name": "Fuzzy planar cell polarity protein", "type": "synonym", "evidence": [ { "id": "E1BBF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBF8/entry#names_and_taxonomy" } ] }, { "name": "fuzzy homolog", "type": "synonym", "evidence": [ { "id": "NP_001179596", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179596" } ] }, { "name": "protein fuzzy homolog", "type": "synonym", "evidence": [ { "id": "NP_001179596", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179596" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBF8", "url": "https://www.uniprot.org/uniprotkb/E1BBF8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FUZ", "url": "https://www.uniprot.org/uniprotkb/E1BBF8", "locus": { "chromosome": "18", "start_pos": 56164028, "end_pos": 56170886, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019183", "url": "https://www.ensembl.org/id/ENSBTAG00000019183" } ] } } ], "crossref": [ { "id": "E1BBF8", "url": "https://alphafold.ebi.ac.uk/entry/E1BBF8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019183", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019183", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21091", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21091", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "528818", "url": "https://www.ncbi.nlm.nih.gov/gene/528818", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026069", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026069", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528818", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528818", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LDQYSCS", "url": "https://omabrowser.org/oma/group/LDQYSCS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBF8", "url": "https://www.orthodb.org/?gene=E1BBF8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13559", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13559", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13559:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13559:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF19036", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19036", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19037", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19037", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5610787", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5610787", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179596", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S4G4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4G4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1W0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1W0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1W0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1W0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBF8", "url": "https://www.uniprot.org/uniprotkb/E1BBF8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBF8-1", "url": "https://www.uniprot.org/uniprotkb/E1BBF8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGEEGTEGTIHLLCLAASSGVPLFCRSSRGGAPARQQLPFSVIGSLNGVHMFGQNLEVQLSSSRTEDTTVVWKSFHDSITLIVLSSEEGTSELRLERLLQMVFGAMVLLVGLEELTNIRNVERLKKELRASYRLIDSFLGDSELIGDLTQCVDCVVPPEGSLLQEALSGFAEAAGTAFISLVVSGRVVAATESWWRLGMPEAVLLPWLVGSLPPQAARDYPVYLPHGSPTVPHRLLTLTLLPDLELCLLCGPQPPLSQLDAQLLERWWQPLLEPLRGCLPLGTRALPAGFPLHTDILGLLLLHLELKRCLFTVEPSRDKEPSPEHRRRLLRSFYTLVTATHFPPEPGQPEEKAEEAIHRAQVARACYLVLGTEEPGTGWRLVALQLGPRRLLLLLSAQSPTYGLRGLATHTLHALTPLL", "length": 419, "header": "tr|E1BBF8-1|E1BBF8_BOVIN Isoform 1 of Fuzzy planar cell polarity protein OS=Bos taurus OX=9913 GN=FUZ PE=3 SV=1 CANONICAL=E1BBF8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4G4-1", "url": "https://www.uniprot.org/uniprotkb/E1BBF8/entry#A0AAA9S4G4-1", "sequence": { "sequence": "MGEEGTEGTIHLLCLAASSGVPLFCRSSRGGAPARQQLPFSVIGSLNGVHMFGQNLEVQLSSSRTEDTTVVWKSFHDSITLIVLSSEEGTSELRLERLLQMVFGAMVLLVGLEELTNIRNVERLKKELRASYRLIDSFLGDSELIGDLTQCVDCVVPPEGSLLQEALSGFAEAAGTAFISLVVSGRVVAATESWWRLGMPEAVLLPWLVGSLPPQAARDYPVYLPHGSPTVPHRLLTLTLLPDLELCLLCGPQPPLSQLDAQLLERWWQPLLEPLRGCLPLGTRALPAGFPLHTDILGLLLLHLELKRCLFTVEPSRDKEPSPEHRRRLLRSFYTLVTATHFPPEPGQPEEKAEEAIHRAQAQLLPTLEEVLGRHLRRLEELVDGHWEFQGAAASGSPADTQC", "length": 403, "header": "tr|A0AAA9S4G4-1|E1BBF8_BOVIN Computationally mapped isoform of Fuzzy planar cell polarity protein OS=Bos taurus OX=9913 GN=FUZ PE=3 SV=1 CANONICAL=E1BBF8-1" }, "locus": { "chromosome": "18", "start_pos": 56170722, "end_pos": 56164147, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120491.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120491.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078149.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078149.1" } ] } }, { "isoform_ac": "A0AAA9T1W0-1", "url": "https://www.uniprot.org/uniprotkb/E1BBF8/entry#A0AAA9T1W0-1", "sequence": { "sequence": "MGEEGTEGTIHLLCLAASSGVPLFCRSSRGGAPARQQLPFSVIGSLNGVHMFGQNLEVQLSSSRTEDTTVVWKSFHDSITLIVLSSEEGTSELRLERLLQMVFGAMVLLVGLEELTNIRNVERLKKELRASYRLIDSFLGDSELIGDLTQCVDCVVPPEGSLLQEALSGFAEAAGTAFISLVVSGRVVAATESWWRLGMPEAVLLPWLVGSLPPQAARDYPVYLPHGSPTVPHRLLTLTLLPDLELCLLCGPQPPLSQLDAQLLERWWQPLLEPLRGCLPLGTRALPAGFPLHTDILGLLLLHLELKRCLFTVEPSRDKEPSPEHRRRLLRSFYTLVTATHFPPAQLVKNPPTIRESWVRSLSWKDPLDKGKVTHTNILAW", "length": 381, "header": "tr|A0AAA9T1W0-1|E1BBF8_BOVIN Computationally mapped isoform of Fuzzy planar cell polarity protein OS=Bos taurus OX=9913 GN=FUZ PE=3 SV=1 CANONICAL=E1BBF8-1" }, "locus": { "chromosome": "18", "start_pos": 56170722, "end_pos": 56166601, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092901.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092901.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090546.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090546.1" } ] } }, { "isoform_ac": "A0AAA9TTZ7-1", "url": "https://www.uniprot.org/uniprotkb/E1BBF8/entry#A0AAA9TTZ7-1", "sequence": { "sequence": "MGEEGTEGTIHLLCLAASSGVPLFCRSSRGGAPARQQLPFSVIGSLNGVHMFGQNLEVQLSSSRTEDTTVVLLVGLEELTNIRNVERLKKELRASYRLIDSFLGDSELIGDLTQCVDCVVPPEGSLLQEALSGFAEAAGTAFISLVVSGRVVAATESWWRLGMPEAVLLPWLVGSLPPQAARDYPVYLPHGSPTVPHRLLTLTLLPDLELCLLCGPQPPLSQLDAQLLERWWQPLLEPLRGCLPLGTRALPAGFPLHTDILGLLLLHLELKRCLFTVEPSRDKEPSPEHRRRLLRSFYTLVTATHFPPEPGQPEEKAEEAIHRAQVARACYLVLGTEEPGTGWRLVALQLGPRRLLLLLSAQSPTYGLRGLATHTLHALTPLL", "length": 383, "header": "tr|A0AAA9TTZ7-1|E1BBF8_BOVIN Computationally mapped isoform of Fuzzy planar cell polarity protein OS=Bos taurus OX=9913 GN=FUZ PE=3 SV=1 CANONICAL=E1BBF8-1" }, "locus": { "chromosome": "18", "start_pos": 56170722, "end_pos": 56165648, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134336.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134336.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100565.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100565.1" } ] } }, { "isoform_ac": "E1BBF8-1", "url": "https://www.uniprot.org/uniprotkb/E1BBF8/entry#E1BBF8-1", "sequence": { "sequence": "MGEEGTEGTIHLLCLAASSGVPLFCRSSRGGAPARQQLPFSVIGSLNGVHMFGQNLEVQLSSSRTEDTTVVWKSFHDSITLIVLSSEEGTSELRLERLLQMVFGAMVLLVGLEELTNIRNVERLKKELRASYRLIDSFLGDSELIGDLTQCVDCVVPPEGSLLQEALSGFAEAAGTAFISLVVSGRVVAATESWWRLGMPEAVLLPWLVGSLPPQAARDYPVYLPHGSPTVPHRLLTLTLLPDLELCLLCGPQPPLSQLDAQLLERWWQPLLEPLRGCLPLGTRALPAGFPLHTDILGLLLLHLELKRCLFTVEPSRDKEPSPEHRRRLLRSFYTLVTATHFPPEPGQPEEKAEEAIHRAQVARACYLVLGTEEPGTGWRLVALQLGPRRLLLLLSAQSPTYGLRGLATHTLHALTPLL", "length": 419, "header": "tr|E1BBF8-1|E1BBF8_BOVIN Isoform 1 of Fuzzy planar cell polarity protein OS=Bos taurus OX=9913 GN=FUZ PE=3 SV=1 CANONICAL=E1BBF8-1" }, "locus": { "chromosome": "18", "start_pos": 56170722, "end_pos": 56165648, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025532.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025532.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025532.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025532.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:528818", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528818", "resource": "KEGG Pathway" }, { "id": "R-BTA-5610787", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5610787", "resource": "Reactome", "description": "Hedgehog 'off' state" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2QBZ8-1", "protein_name": "Protein fuzzy homolog isoform X1", "gene_name": "Fuz", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGDEGAGSTVHLLCLAASSGVPLFCRSSCGGAPSRQQLPFSVIGSLNGVHMFGQNLDVQLNSARTEDTTVVWKSFHDSITLIALSSEEGTSELRLERMLHMVFGAMVLIVGLEELTNIRNVERLKKELRASYCLIDSFLGNSELIGDLTQCVDCVIPPEGSFMQETLSGFAEATGTAFVSLLVSGRVVAATEGWWRLGMPEAVLLPWLVGSLPPQAARDYPVYLPHGSPTVPHRLLTLTLLRGLELCLLCGPRPPLSQLDPQLLERWWQPLLEPLRACLPLGPRVLPEGFPLHSDILGLLLLHLDLRRCLFTVEPSRNKEPSPEQRRRLLRNFYTLVATTHFSPEPGPTEKEEDEAHPAQSPRACYLVLGPGEGWRLVALQLGLRLLLLMLSPQSPTHGLRSLATHTLQALTPFL", "length": 415 }, "evidence": [ { "id": "E1BBF8", "url": "https://omabrowser.org/oma/group/E1BBF8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1RH61-1", "protein_name": "Fuzzy planar cell polarity protein", "gene_name": "FUZ", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGEEGTEGMVHLLCLAASSGVPLFCRSSRGGAPARQQLPFSVIGSLNGVHMFGQNLEVQLSSARTEDTTVVWKSFHDSITLIVLSSEEGTSELRLERLLQMVFGAMVLLVGLEELTNIRNIERLKKELRASYRLIDSFLGNSELIGDLTQCVDCVVPPEGSLLQEALSGFAEAVGTAFVSLVVSGRVVAATESWWRLGMPEAVLLLWLVGSLPPQAARDYPVYLPHGSPMVPHRLLTLTLLPGLELCLLCGPRPPLSQLDAQLLERWWQPLLDPLRACLPLGPRALPGGFPLHADILGLLLLHLELKRCLFTVELSGDKEPSPGQRRRLLRSFYTLVTATYFPPEPGQPEKVEEAVHRAQVPRACYLVSGPEEPGIGWRLVALQLGPRRLLLLLSAQSPTHGLRGLATHTLHALTPLL", "length": 418 }, "evidence": [ { "id": "E1BBF8", "url": "https://omabrowser.org/oma/group/E1BBF8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O16868-1", "protein_name": "Protein fuzzy", "gene_name": "fuz", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSIYLLCLTTNGGLPVFTRKKGECENLPFSTVASLNGFHMFFKSLGIQLEATTTSKQQPIQNQAPADAEEWTYIWRDRESITLIVCGCGVGSEQLLQTLADLVFGAIGMFITRAAEMAHATLLDRLKKDAKKYVPIVDAILEAACAGTQLLGYTDCLLAAENAQLLQCLNEFSGHCGSLFCCLVVGHRIAVATEGWWDLDTRDRELLLFLLNSSSTMQHDVPVYLPVKSPHIAYRFVSIPVASNSALCVLCGAENASFRELHAHAMSAYRNEGNLLAAAERCVPRSLPEHLEIDGNVLAIILINRHTRKSLFTRNLNQSASVKRIIVGDLQRLDILKKFFDQTMDAVHQFETQSSSNKTTLVDQYSCSDYHKCYAHMDELGNVIFLLFVAAVPSHAMRFLAQRIHANILQEKSVCW", "length": 416 }, "evidence": [ { "id": "E1BBF8", "url": "https://omabrowser.org/oma/group/E1BBF8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q3B756-1", "protein_name": "Protein fuzzy homolog", "gene_name": "Fuz", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGDDGPGSTVHLLCLAASSGVPLFCRSSSGGAPSRQQLPFSVIGSLNGVHMFGQNLDVQLNSARTEDTTVVWKNFHDSITLIALSSEEGTSELKLERMLHMVFGAMVLIVGLEELTNIRNVERLKKELRASYCLIDSFLGNSELIGDLTQCVDCVIPPEGSVMQETLSGFAEATGTAFVSLLVSGRVVAATDGWWRLGMPEAVLLPWLVGSLPPQAARDYPVYLPHGSPTVPHRLLTLTLLRGLELCLLCGPRPPLGELDPQLLERWWQPLLEPLRACLPLGPRALPDGFPLHSDILGLLLLHLELRRCLFTVEPSKDKEPSPEQRRRLLRNFYTLVATTHFPPEPGPAEKQEDTVHPAQTPRACYLVLGPGMGWQLVAVQLGLRLLLLMLSPQTPTHGLRSLATHTLQALTPLL", "length": 415 }, "evidence": [ { "id": "E1BBF8", "url": "https://omabrowser.org/oma/group/E1BBF8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3UYI6-1", "protein_name": "Protein fuzzy homolog", "gene_name": "Fuz", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGDEGPGSPVHLLCLAASSGVPLFCRSSSGGAPSRQQLPFSVIGSLNGVHMFGQNLDVQLNSARTEDTTVVWKNFHDSITLIVLSSEEGTSELRLERMLHMVFGAMVLIVGLEELTNIRNVERLKKELRASYCLIDSFLGNSELIGDLTQCVDCVIPPEGSAMQETLSGFAEATGTAFVSLLVSGRVVAATEGWWRLGMPEAVLLPWLVGSLPPQAARDYPVYLPHGSPTVPHRLLTLTLLRGLELCLLCGPRPPLGQLDPQLMERWWQPLLEPLRACLPLGPRALPEGFPLHSDILGLLLLHLELRRCLFTMEPSKDKEPSPEQRRRLLRNFYTLVATTHFPPEPGPAEKQEDTVYPAQMPRACYLVLGPGMGWQLVAVQLGLRLLLLLLSPHTPTHGLRSLATRTLQALTPLL", "length": 415 }, "evidence": [ { "id": "E1BBF8", "url": "https://omabrowser.org/oma/group/E1BBF8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BT04-1", "protein_name": "Protein fuzzy homolog", "gene_name": "FUZ", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGEEGTGGTVHLLCLAASSGVPLFCRSSRGGAPARQQLPFSVIGSLNGVHMFGQNLEVQLSSARTENTTVVWKSFHDSITLIVLSSEVGISELRLERLLQMVFGAMVLLVGLEELTNIRNVERLKKDLRASYCLIDSFLGDSELIGDLTQCVDCVIPPEGSLLQEALSGFAEAAGTTFVSLVVSGRVVAATEGWWRLGTPEAVLLPWLVGSLPPQTARDYPVYLPHGSPTVPHRLLTLTLLPSLELCLLCGPSPPLSQLYPQLLERWWQPLLDPLRACLPLGPRALPSGFPLHTDILGLLLLHLELKRCLFTVEPLGDKEPSPEQRRRLLRNFYTLVTSTHFPPEPGPPEKTEDEVYQAQLPRACYLVLGTEEPGTGVRLVALQLGLRRLLLLLSPQSPTHGLRSLATHTLHALTPLL", "length": 418 }, "evidence": [ { "id": "E1BBF8", "url": "https://omabrowser.org/oma/group/E1BBF8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "E1BBF8", "url": "https://www.uniprot.org/uniprotkb/E1BBF8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "E1BBF8", "url": "https://www.uniprot.org/uniprotkb/E1BBF8" } ], "pmid": "" }, { "name": "negative regulation of cell migration", "id": "GO:0030336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030336", "evidence": [ { "database": "UniProtKB", "id": "E1BBF8", "url": "https://www.uniprot.org/uniprotkb/E1BBF8" } ], "pmid": "" }, { "name": "neural tube closure", "id": "GO:0001843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001843", "evidence": [ { "database": "UniProtKB", "id": "E1BBF8", "url": "https://www.uniprot.org/uniprotkb/E1BBF8" } ], "pmid": "" }, { "name": "non-motile cilium assembly", "id": "GO:1905515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905515", "evidence": [ { "database": "UniProtKB", "id": "E1BBF8", "url": "https://www.uniprot.org/uniprotkb/E1BBF8" } ], "pmid": "" }, { "name": "positive regulation of cilium assembly", "id": "GO:0045724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045724", "evidence": [ { "database": "UniProtKB", "id": "E1BBF8", "url": "https://www.uniprot.org/uniprotkb/E1BBF8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBF8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 419, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBF8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBF8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBF8" }, { "id": "PF19036", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19036" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FUZ/MON1/HPS1 first Longin", "eco_id": "ECO_0000259", "start_pos": 11, "end_pos": 137, "start_aa": "His", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BBF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBF8" }, { "id": "PF19037", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19037" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FUZ/MON1/HPS1 second Longin", "eco_id": "ECO_0000259", "start_pos": 175, "end_pos": 269, "start_aa": "Gly", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BBF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBF8" }, { "id": "PF19038", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19038" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FUZ/MON1/HPS1 third Longin", "eco_id": "ECO_0000259", "start_pos": 296, "end_pos": 416, "start_aa": "Ile", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { 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"count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BBQ0-1", "uniprot_ac": "E1BBQ0", "uniprot_id": "E1BBQ0_BOVIN", "mass": { "chemical_mass": 250668.0, "monoisotopic_mass": 250668.0 }, "refseq": { "ac": "NP_001179020", "name": "kinetochore-associated protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179020" }, "gene_names": [ { "name": "KNTC1", "type": "recommended", "evidence": [ { "id": "E1BBQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0" } ] }, { "name": "KNTC1", "type": "synonym", "evidence": [ { "id": "NP_001179020", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179020" } ] } ], "protein_names": [ { "name": "Kinetochore associated 1", "type": "synonym", "evidence": [ { "id": "E1BBQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0/entry#names_and_taxonomy" } ] }, { "name": "kinetochore-associated protein 1", "type": "synonym", "evidence": [ { "id": "NP_001179020", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179020" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBQ0", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KNTC1", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0", "locus": { "chromosome": "17", "start_pos": 52854278, "end_pos": 52922614, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019278", "url": "https://www.ensembl.org/id/ENSBTAG00000019278" } ] } } ], "crossref": [ { "id": "ENSBTAG00000019278", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019278", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506353", "url": "https://www.ncbi.nlm.nih.gov/gene/506353", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052802", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052802", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055403", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055403", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055405", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055405", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506353", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506353", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FYELYLC", "url": "https://omabrowser.org/oma/group/FYELYLC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BBQ0", "url": "https://www.orthodb.org/?gene=E1BBQ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15688", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15688", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15688:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15688:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10493", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10493", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24506", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24506", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24515", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24515", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-141430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-141444", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2500257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9648025", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179020", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S4X0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4X0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4X0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4X0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBQ0", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBQ0-1", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWNDIELLTNDDTGSGYLSVGSGKEHGTALYQVDLLAKISSEKASLNPKIQACSLSDGFIIIADQSVILLDSICRSLQLHLTFDTEVDVVGLCQEGKFLLVGERSGNLHLIHVTSKLTLLTNAFVQKANDENQCTYRNLVIEKDSSSEDTYYMLLLTNNGLFYITNLQLVKIQQAIEKADFDTAKKLQGQIKSSFISTENYHTLGCLNLVAGDLASEIPVIIGGTGNCALSKWEPDSSRKGMTVKSVIDSEIIKGAKKFQLIDNLLFVLDTDNVLSLWDIYTLTPIWNWPVLHVEEFLLTTEAESPSSVTWQGITNLKLVALTTTTNKKMKNLVVCSLPAMEILYSLEVSGISSLVQTGISTDTIYLLEGIFKNDPSLSEDSVSVLALRCLTEALPENRLSRLLHKHRFAEAESFAIQFGLDVELVYKVKSNDILEKLALSSLDTSEQTKWQKLVNEAKENLHKIQDDEFVMNYCLEAQWITYETTHEMLNYAKTRLLKKEDKTVLVYSDGLKEVLRAHAKLTTFYGAFGPEKFSGSSWIEFLNNEDDLKDIFLQLREGNLVCAQYLWLRHRANFESRFDVKMLENLLNSISTPISLQKLCPWLKNDVIPFVRKTVPEGQKILAKWLEQAARNLELTDKANWPENGLQLAEVFFTAENELGLASSWSWSSLDNQNMEEVCQLRTLVNNLRELITLHRKYNCKLALSDFEKEDTTTIVFRMFDKVLAPELIPSIFQKFIRVYMHEHDLQEEELLLLYIEDLLKRCSSKFTSLFDTAWEAKAMAVIGCLSDTDLIFDAVLKIMYAAVVPWSAAVEQLVKQHLEMGHPKVKLLQESYKLMEMKKLLRGYGIREVNLLNKEIMRVVRYILKQDVPSSLEDALKVAEAYMLPKDEIYSLRIIDLIDREQGEDCVLLLRSLPLAEAKKTAERVIIWARLALQEEPDTSNEDKAWRLSVAKTSVDILKILCNSQKDNLQKKDEWEETLKQFKTVASLQENFEVFLSFEDYSKSSLVAELREQHIKAHQVAQAKHKPWRPAEPRATEEQRLSAESKLHRQALTLQVSRQQLEAELTLRALSDGNVEAALRKCRDLFKYHCNTDTGQFLFLMCQKLCHMLASGVPMTVPVGLNLPSEIHDLACQAATICSPDFVLDALELCKYTLMAVELSRQCQMDDCGILTKTSFGTHKDPYEEWSYCDFFSEDGIVLESQMVLPVIYELISSLVPLAESKRYPLDSVSLPYCFTSEGDSLMLPVINSISALLQNLQESSQWELALKFVIGSFGTCLQHSVSSFMNASLSEKLFEEAPLVKSRHVVMELKEKAVMFIRGNATTLLYKVFNCRLVDLDLALGYCTLLPQKEVFENLWKLTDKAWQNYDKILAISLVGSQLASLCQETETKFKFCELSTDARWGIRLSKLGISFQPVFRQHFLTKNDLIKALVKNIDMDTSIILEYCSTFQLDADAALQLFIETLLHNTNASQSQGDVSTGSTKQQRSKLLAKALEMVPLLTSTKDLVISLSGILHKLDPYDYEMIEVVLKVIERADEKITNININQALSLLKHLKSYRRISPPVDLEHQYMLEHVITLPSAAQTRLPFHLIFFGTAQSFWKILSTELSEESFPTLLLVSKLMKFSLDTLYVSTAKHVFEKKLKPKLLQLTQGKSSTLINKEIAKITQTIESYLLSIVNPEWAVAIAISLAQDVPEGSFKMSSLKFCLYLAERWLQNIPSQDETREKAEALLKKLHVQYRRSGTEAVLIAHKLNTAEYLRVIGKPVHLIVSLYEHPSINQRIQNSCGKDYPDIHTAAKEIAEVNEINLEKVWDMLLEKWLCPSAKPDETPSELFELQEDETLRRVLYLLLSRPVDYSSRMLFIFATSATTMLRMHQLTFAHRTRALQCLLYLADKETIESLFKKSIEEVKSYLKCITFLASFEALNIPITYELFCNSPKEGMIKGLWKNHSHEPMAVKLVTELCLEYKIYDLQLWNGLLQKLLGFNMIPYLRKVLTAISSIYPLWQVPYFGRAWQCVVQIPLLSASCPLSPSQLSDCCESLIAVLECPVSDDLDMIRVARQYVQLELPAFALACLMLMPHSEKRHQEIKNFLSSCDPQIILQQLEEHMNTGQLAGFSHQIRSLVLKNIIDKKEFGILAKTKYFPVLKSHMMNTNNITELVNYLADELSLDDASVFITEYYKHCGKPIPPGTTPCETLKMFNGS", "length": 2204, "header": "tr|E1BBQ0-1|E1BBQ0_BOVIN Isoform 1 of Kinetochore associated 1 OS=Bos taurus OX=9913 GN=KNTC1 PE=4 SV=3 CANONICAL=E1BBQ0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4X0-1", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0/entry#A0AAA9S4X0-1", "sequence": { "sequence": "MWNDIELLTNDDTGSGYLSVGSGKEHGTALYQVDLLAKISSEKASLNPKIQACSLSDGFIIIADQSVILLDSICRSLQLHLTFDTEVDVVGLCQEGKFLLVGERSGNLHLIHVTSKLTLLTNAFVQKANDENQCTYRNLVIEKDSSSEDTYYMLLLTNNGLFYITNLQLVKIQQAIEKADFDTAKKLQGQIKSSFISTENYHTLGCLNLVAGDLASEIPVIIGGTGNCALSKWEPDSSRKGMTVKSVIDSEIIKGAKKFQLIDNLLFVLDTDNVLSLWDIYTLTPIWNWPVLHVEEFLLTTEAESPSSVTWQGITNLKLVALTTTTNKKMKNLVVCSLPAMEILYSLEVSGISSLVQTGISTDTIYLLEGIFKNDPSLSEDSVSVLALRCLTEALPENRLSRLLHKHRFAEAESFAIQFGLDVELVYKVKSNDILEKLALSSLDTSEQTKWQKLVNEAKENLHKIQDDEFVMNYCLEAQWITYETTHEMLNYAKTRLLKKEDKTVLVYSDGLKEVLRAHAKLTTFYGAFGPEKFSGSSWIEFLNNEDDLKDIFLQLREGNLVCAQYLWLRHRANFESRFDVKMLENLLNSISTPISLQKLCPWLKNDVIPFVRKTVPEGQKILAKWLEQAARNLELTDKANWPENGLQLAEVFFTAENELGLASSWSWSSLDNQNMEEVCQLRTLVNNLRELITLHRKYNCKLALSDFEKEDTTTIVFRMFDKVLAPELIPSIFQKFIRVYMHEHDLQEEELLLLYIEDLLKRCSSKFTSLFDTAWEAKAMAVIGCLSDTDLIFDAVLKIMYAAVVPWSAAVEQLVKQHLEMGHPKVKLLQESYKLMEMKKLLRGYGIREVNLLNKEIMRVVRYILKQDVPSSLEDALKVAEAYMLPKDEIYSLRIIDLIDREQGEDCVLLLRSLPLAEAKKTAERVIIWARLALQEEPDTSNEDKAWRLSVAKTSVDILKILCNSQKDYSKSSLVAELREQHIKAHQVAQAKHKPWRPAEPRATEEQRLSAESKLHRQALTLQVSRQQLEAELTLRALSDGNVEAALRKCRDLFKYHCNTDTGQFLFLMCQKLCHMLASGVPMTVPVGLNLPSEIHDLACQAATICSPDFVLDALELCKYTLMAVELSRQCQMDDCGILTKTSFGTHKDPYEEWSYCDFFSEDGIVLESQMVLPVIYELISSLVPLAESKRYPLDSVSLPYCFTSEGDSLMLPVINSISALLQNLQESSQWELALKFVIGSFGTCLQHSVSSFMNASLSEKLFEEAPLVKSRHVVMELKEKAVMFIRGNATTLLYKVFNCRLVDLDLALGYCTLLPQKEVFENLWKLTDKAWQNYDKILAISLVGSQLASLCQETETKFKFCELSTDARWGIRLSKLGISFQPVFRQHFLTKNDLIKALVKNIDMDTSIILEYCSTFQLDADAALQLFIETLLHNTNASQSQGDVSTGSTKQQRSKLLAKALEMVPLLTSTKDLVISLSGILHKLDPYDYEMIEVVLKVIERADEKITNININQALSLLKHLKSYRRISPPVDLEHQYMLEHVITLPSAAQTRLPFHLIFFGTAQSFWKILSTELSEESFPTLLLVSKLMKFSLDTLYVSTAKHVFEKKLKPKLLQLTQGKSSTLINKEIAKITQTIESYLLSIVNPEWAVAIAISLAQDVPEGSFKMSSLKFCLYLAERWLQNIPSQDETREKAEALLKKLHVQYRRSGTEAVLIAHKLNTAEYLRVIGKPVHLIVSLYEHPSINQRIQNSCGKDYPDIHTAAKEIAEVNEINLEKVWDMLLEKWLCPSAKPDETPSELFELQEDETLRRVLYLLLSRPVDYSSRMLFIFATSATTMLRMHQLTFAHRTRALQCLLYLADKETIESLFKKSIEEVKSYLKCITFLASFEALNIPITYELFCNSPKEGMIKGLWKNHSHEPMAVKLVTELCLEYKIYDLQLWNGLLQKLLGFNMIPYLRKVLTAISSIYPLWQVPYFGRAWQCVVQIPLLSASCPLSPSQLSDCCESLIAVLECPVSDDLDMIRVARQYVQLELPAFALACLMLMPHSEKRHQEIKNFLSSCDPQIILQQLEEHMNTGQLAGFSHQIRSLVLKNIIDKKEFGILAKTKYFPVLKSHMMNTNNITELVNYLADELSLDDASVFITEYYKHCGKPIPPGTTPCETLKMFNGS", "length": 2171, "header": "tr|A0AAA9S4X0-1|E1BBQ0_BOVIN Computationally mapped isoform of Kinetochore associated 1 OS=Bos taurus OX=9913 GN=KNTC1 PE=4 SV=1 CANONICAL=E1BBQ0-1" }, "locus": { "chromosome": "17", "start_pos": 52922573, "end_pos": 52855713, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100916.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100916.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080982.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080982.1" } ] } }, { "isoform_ac": "E1BBQ0-1", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0/entry#E1BBQ0-1", "sequence": { "sequence": "MWNDIELLTNDDTGSGYLSVGSGKEHGTALYQVDLLAKISSEKASLNPKIQACSLSDGFIIIADQSVILLDSICRSLQLHLTFDTEVDVVGLCQEGKFLLVGERSGNLHLIHVTSKLTLLTNAFVQKANDENQCTYRNLVIEKDSSSEDTYYMLLLTNNGLFYITNLQLVKIQQAIEKADFDTAKKLQGQIKSSFISTENYHTLGCLNLVAGDLASEIPVIIGGTGNCALSKWEPDSSRKGMTVKSVIDSEIIKGAKKFQLIDNLLFVLDTDNVLSLWDIYTLTPIWNWPVLHVEEFLLTTEAESPSSVTWQGITNLKLVALTTTTNKKMKNLVVCSLPAMEILYSLEVSGISSLVQTGISTDTIYLLEGIFKNDPSLSEDSVSVLALRCLTEALPENRLSRLLHKHRFAEAESFAIQFGLDVELVYKVKSNDILEKLALSSLDTSEQTKWQKLVNEAKENLHKIQDDEFVMNYCLEAQWITYETTHEMLNYAKTRLLKKEDKTVLVYSDGLKEVLRAHAKLTTFYGAFGPEKFSGSSWIEFLNNEDDLKDIFLQLREGNLVCAQYLWLRHRANFESRFDVKMLENLLNSISTPISLQKLCPWLKNDVIPFVRKTVPEGQKILAKWLEQAARNLELTDKANWPENGLQLAEVFFTAENELGLASSWSWSSLDNQNMEEVCQLRTLVNNLRELITLHRKYNCKLALSDFEKEDTTTIVFRMFDKVLAPELIPSIFQKFIRVYMHEHDLQEEELLLLYIEDLLKRCSSKFTSLFDTAWEAKAMAVIGCLSDTDLIFDAVLKIMYAAVVPWSAAVEQLVKQHLEMGHPKVKLLQESYKLMEMKKLLRGYGIREVNLLNKEIMRVVRYILKQDVPSSLEDALKVAEAYMLPKDEIYSLRIIDLIDREQGEDCVLLLRSLPLAEAKKTAERVIIWARLALQEEPDTSNEDKAWRLSVAKTSVDILKILCNSQKDNLQKKDEWEETLKQFKTVASLQENFEVFLSFEDYSKSSLVAELREQHIKAHQVAQAKHKPWRPAEPRATEEQRLSAESKLHRQALTLQVSRQQLEAELTLRALSDGNVEAALRKCRDLFKYHCNTDTGQFLFLMCQKLCHMLASGVPMTVPVGLNLPSEIHDLACQAATICSPDFVLDALELCKYTLMAVELSRQCQMDDCGILTKTSFGTHKDPYEEWSYCDFFSEDGIVLESQMVLPVIYELISSLVPLAESKRYPLDSVSLPYCFTSEGDSLMLPVINSISALLQNLQESSQWELALKFVIGSFGTCLQHSVSSFMNASLSEKLFEEAPLVKSRHVVMELKEKAVMFIRGNATTLLYKVFNCRLVDLDLALGYCTLLPQKEVFENLWKLTDKAWQNYDKILAISLVGSQLASLCQETETKFKFCELSTDARWGIRLSKLGISFQPVFRQHFLTKNDLIKALVKNIDMDTSIILEYCSTFQLDADAALQLFIETLLHNTNASQSQGDVSTGSTKQQRSKLLAKALEMVPLLTSTKDLVISLSGILHKLDPYDYEMIEVVLKVIERADEKITNININQALSLLKHLKSYRRISPPVDLEHQYMLEHVITLPSAAQTRLPFHLIFFGTAQSFWKILSTELSEESFPTLLLVSKLMKFSLDTLYVSTAKHVFEKKLKPKLLQLTQGKSSTLINKEIAKITQTIESYLLSIVNPEWAVAIAISLAQDVPEGSFKMSSLKFCLYLAERWLQNIPSQDETREKAEALLKKLHVQYRRSGTEAVLIAHKLNTAEYLRVIGKPVHLIVSLYEHPSINQRIQNSCGKDYPDIHTAAKEIAEVNEINLEKVWDMLLEKWLCPSAKPDETPSELFELQEDETLRRVLYLLLSRPVDYSSRMLFIFATSATTMLRMHQLTFAHRTRALQCLLYLADKETIESLFKKSIEEVKSYLKCITFLASFEALNIPITYELFCNSPKEGMIKGLWKNHSHEPMAVKLVTELCLEYKIYDLQLWNGLLQKLLGFNMIPYLRKVLTAISSIYPLWQVPYFGRAWQCVVQIPLLSASCPLSPSQLSDCCESLIAVLECPVSDDLDMIRVARQYVQLELPAFALACLMLMPHSEKRHQEIKNFLSSCDPQIILQQLEEHMNTGQLAGFSHQIRSLVLKNIIDKKEFGILAKTKYFPVLKSHMMNTNNITELVNYLADELSLDDASVFITEYYKHCGKPIPPGTTPCETLKMFNGS", "length": 2204, "header": "tr|E1BBQ0-1|E1BBQ0_BOVIN Isoform 1 of Kinetochore associated 1 OS=Bos taurus OX=9913 GN=KNTC1 PE=4 SV=3 CANONICAL=E1BBQ0-1" }, "locus": { "chromosome": "17", "start_pos": 52922573, "end_pos": 52855713, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025676.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025676.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025676.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025676.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506353", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506353", "resource": "KEGG Pathway" }, { "id": "R-BTA-141430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "resource": "Reactome", "description": "Inactivation of APC/C via direct inhibition of the APC/C complex" }, { "id": "R-BTA-141444", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "resource": "Reactome", "description": "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2500257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "resource": "Reactome", "description": "Resolution of Sister Chromatid Cohesion" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" }, { "id": "R-BTA-9648025", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "resource": "Reactome", "description": "EML4 and NUDC in mitotic spindle formation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AML8-1", "protein_name": "Kinetochore associated 1", "gene_name": "KNTC1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MWSDIELLTSDDTGSGYLSVGSRKEHGTALYQVDLLAKISSEKALLNPKIQACSLSDGFIIVADQSVILLDSVCRSLQLHLVFDTEVDVVGLCQEGKFLLVGERSGNLHLIHVTSKQTLLTNAFVQKANDENQRTYRNLVIEKDGSREGTYYMLLLTNNGFFCVTNLQLVKIQQAIEKVDFDTAKKLQGQIKSSFISTENYHTLDCLNLVAGDLASEVPVIIGGTGNCAFSKWEPDASRKGMTVKNVSDAEIIQGAKKFQLIDNLLFVLDTDNVLSLWDIYTLTPIWNWPSLHIEEFLLTTEADSPSSVTWQGITNLKLVALTTTTNKKIKNLMVYSLPVMEILYSLEVSSVSSLVQRGISTDTIYLLEGICKSDPRLSEDSVSVLVLRCLTEALPENRLSRLLHKHRFAEAESFAIQFGLDVELVYKVKANDILEKLALSSLDTHEQSKWQKLVNEAKENLHKIQDDEFVVNYCLEAQWITYETTQQMLNYAKNRLLKKEDKTIPVYSDGLKEVLRAHAKLTTFYGAFGPEKFSASSWIEFLNNEDDLRDIFLQLREGNLVCAQYLWLRHRAYFETRFDVKMLENLLNSISTPVSLQKLCPWLKNDVIPFVRRTIPKGQKILAKWLEQAARNLELTDKANWPENGLQLAEVFFTAEKPNELGLASSWRWSSLDYQNTEEVCQLRTLINNLRELITLHRKYNCKLALSDFEKENTTTIVFRMFDKVLAPELISSVFEKFIRVYMREHDLQEEELLLLYIEDLLKRCSSKSTSLFDTAWEAKAMAVIGCLSDTDLIFDAVLKIMYAAVVPWSAAVEQLVKQHLEMDHPKVKLLQESYKLMEMKKLLRGYGIREVNLLNKEIMRVVRYILKQDIPSSLEDALKVAEAYMLPKDEIYSLRIIDLIDREQGEDCILLLRSMAPAEAQKTAERVIIWAQLALQEEPDNSNEDKAWRMSIAKTSVDILKVLCDIQKDNLQKKDEWEETLKEFKSVVSLQENFEVFLSFGDYNNSSLVADLREQHIKALQDAQAKCRSQRPAEPTDTQKKRLHAEAKLHRQALALQVSRQELEFELTLRALNDGNVEAALRKCRDLFKYHRKADTGELLFLTCQKLCQMLAHGIPMTIPKGLNLPSEIHDLACQAATICSPDFLLDALELCKYTLTAVELSRQCQMDDCGILMKTSLGTHKDPYEEWSYSDFFSEDGIVLESHMVLPVIYELISSLVPLAESKRYPLDSTSLPYCSISEGNSLVLPVVSSISALLQNLQESSQWELALRFVVGSFGTCLQHSMSNFMNASLSEKLFGEATLVKSRDVVMELKEKAVTFIKGNATTLLYKVFNCRLVDHDLALGYCTLLPQKAVFENLWKLIDKAWQNYDKVLAISLVGSKLASLYQETEMELKFCELSTDAQWGIRLSKLGISFQPVFRQHFLTKKDLIKALVKNIDMDTSLILEYCSTFQLDSDAALQLFIETLLHNTNASQSQGDANTESTQEQRSKLLAKAIEMVPLLRSTKDLVISLSGILHKLDPYDYEMIEVVLKVIERADEKITNININQALSLLKHLKSYRRISPPVDLEYQYMLEHVITLPSAAQIRLPFHLIFFGTAQNFWKILSTELSEESFPTLLLISKLMKFSLDTLYVSTAKHVFEKKLKPKLLLLTQAKSSTLINKEITKITQTIESYLLSIVNPEWAVAIAISLAQDVPEGSFKMSSLKFCLYLAERWLQNIPSEDETHEKAEALLKKLHIQYRRSGTEAVLIAHKLNTTEYLRMIGKPAHLIVSLYEHPSINQRIQDSSGKDYPDIHAAAKEIAEVNEINLEKVWDMLLEKWLCPSTQPGEKPSELFELQEDEALRRVLYLLLSRPIDYSSRMLFIFATSATTTLGVHQLTYAHRTRALQCLLYLADKDTIESLFKKTIEEVKSYLKSITFLASFETLNIPITYELFCNSPKEGMIKGLWKNHSHESMAVKLVTELCLEYKIYDLPLWNGLLQKLLGFNMIPYLRKVLTAISSIHSLWQVPYFSKAWQRVIQIPLLSASCPLSPSQLSDCCESLIAVLECPVSDDLDLIRVARQYVQLDLPAFALACLMLMPHSEKRHQEIKNFLGSCDPQIVLQQLEEHMNTGRLAGFSHQIRSLVLNNIIDKKEFGILAKTKYFTVLKSHMMNTNSITELVNYLANELSLDEASVFITEYYKHCGKPVPPDATPCETLKMFLNGS", "length": 2207 }, "evidence": [ { "id": "E1BBQ0", "url": "https://omabrowser.org/oma/group/E1BBQ0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6G9X6-1", "protein_name": "Kinetochore associated 1", "gene_name": "Kntc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWNNIELLTSDDTGSGFLNVGSRKESVTALYQVDLLGKISSEKTSLSPKIQACSLSDGFIIVADQSVILLDSTCRSLQLFLIFDTDVDVVGLCPEGKFLFVGERSGNFHLIYVTSKRTLFTKAFVEKAEDERTYRSLVIEKDGSNEGTYYMLLLTNNGFFYITNLQLSQIEQAIENTDLDSAKKLQGQFKCSFISTESYHSSGCLNLLASQSGKFANETSVIIGGTGSCAFSKWEPDSTKKDMSLKNFVDTDIIRGAKSFQLIDNLLFVLDTDNVLSLWDAYTLTPVWNWPSLPIEQFLLTTEADSPSSVTWQGITNLKLVTLTATTKEKMRNLIIYSLPTMEILYSLEVSSVSSLVQTGISTDTIYLLEGVHKNDPNLCEDSVSNLELRYLTEVLPENRLSRLLHKHRFADAESFAIQFGLDVELVYKVKSNDILEKLALISDKSEQSEWQQLVDEAKENLCKIQDDDFVVNFCLKAQWVTYETTQEMLSYAKTRLMKKEDRTLPACSDDFLEVLKAHAKLTTFYGAFGPEKFSGSAWVEFLNNEDDLKDIFVQLSEGNFDCAQYLWLRHRADFESKFDVKMLENLLNSISTQIPVEKLCSWFKNDVIPFVRRIVPEGQNILAKWLEQASRNLELTDKANWPENGLQLAEVFFTAEKTDKFGFSSSWHWISLKDYQNTEEVQQLRTLVSKLQELIILHRKYNCRLALSEFEKENATTVVFRMFDRVSAPELIPSVLEKFVRVYIREQNLQEEELLLLYIEDLLKRCSSKSMTLFDTAWEAKAMAVIRCLSDTDLIFDAVLKIMYKAVVPWSAAVEQLVRQHLEMDHPKVKLLQESYRLMEMKKLLRGYGIREVNLLNKEIMRVVRYILKQDIPSSLEDALKVAQGYRLSDDEIYSLRVIDLIDRDQGEDCLLLLRSLPPSEAEKTAERVIIWARLALQEEPDGSEEDKAWRISVAKTSMDILKILCDIQKDNLQKKDDAEEFLKRFKMVASLQENFEVFLPFEDYSDTGLVAGLREQYIKAQENAQAEHKFRGPPGPTPAMGTNASVKSKLHRQALVLQVSTQELEAEMALRALKDGKVAVALSKCRDLLKHYCNADTGRLLFVVCQKLCHMLADDVPMVAPVGLNLPSEIHDLTCHAVTICSPDFLLDVLELSKYTLTAVELCRQCQMDDCGILMKAAVGTHKDPYEEWSYSDFFSEDGIVLESQVVLPVIYELISSVVPLAEGKRRPLDSISLPYCSTSEGENLILPLVSSISALLRNLQESSQWELALRFVVASFGTCLQHSVSNVMSMSLSEKLLGKSTLASSRQIIMELKEKSIAFIRGSATTLLHKVFNCRLVDLDLALAYCTLLPQKDVFENLWKFIDKAWQNYDKILALSLVGSRLANLYQDVETGLRFHELSIDAKWGIRLGKLGISFQPAFRQNFLSKKDLIKALVNNIDMDTSLILEYCSTFQLDSDAALRLFIETLLRNTTSQSQGGDAPEPTQHQHSKLLQKATEMVPLLKSTKDLVISLTEILYKLDPYDYEMIEVVLKVIEQANEKITTVNINQALNLLRHLKSYRRMSPPVDLEYQYMLEHLITLPPAAQTRLPFHLILFGTAQNFWKILSSELSEESLPTLLLISKLMKFSLDTLYVSTAKHVFEKNLKPKLLKSAQARSSVMSKEVDKLVQTLESYLLSIVNPEWAVAIAISLTQEIPEGPFKMTSLKFCLYLAERWLQNIPPQDETCEKVKALQKKLYLQFRLSGTEAVLIAHKLNDQEYLRVVGKPAHLIVSLYEHPSISERLCTTSGKDYPDIHAAAKEIAEVNEINLEKIWDMLLEKWLCPSTAPGEKASEFFELEEDEVLHRVVYLLQARPIDYSSRMLFVFATSATSTLGIRQLTFAHRARALQCLLYLADKETIESLFKKPTEEMKSYLKCITFLASFETLNIPITYELFCNSPKEGMIKGLWKNHSHEPMAVRLVAELCLEYKIYDLQLWNGLLQKLLGFNMIPYLRKVLSCISSVHSLWQVPYFSKAWQRVIQIPLLSASCPLRPSQLADCCESLVAILECPVSDDLDMMGVAKQYVQLELPAFALTCLTLMPHSEKRHQQIKNFLNSCDAQIILQQLEEHMNAGQLAGLSQQIRSLVLNHVVNKKEFGILAKTKYFQLLKRHVINTDNVTELVNYLANDLSLDEASSLITEYSKHCGKPVPADTAPSEILKTFLGS", "length": 2205 }, "evidence": [ { "id": "E1BBQ0", "url": "https://omabrowser.org/oma/group/E1BBQ0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V1A857-1", "protein_name": "Kinetochore associated 1", "gene_name": "KNTC1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLVTMWNDIEILVNDDTRREQLSVCLGQECGSALYQVDSLLQITSSEKISVNPQLYACSSRDGSIIVVDRSVVLLDSTGQALQLHIQFDTNVDVVGMCQEKQFLVVGERSGNIHLVHIPSKKTLLTKILVETSSSEKTYLNLFIEKDTAVAGVYHMFILTDKGFFCIMCLPLAKTQEAINKMDMAAAMKLQGQIKTAFIATEEYHSLGCQNFVISNLANKIHMIIGGKGDYVLSKWEVDATNNLVSVRSFADSSLIKDAVKLQVLDNLLFVLDTENILSIWDVFSLTLIWDWPLIHVEEFLLTTESDSSSVMQQGLAGVKLIVMTTSTNKQMRSLMVFALPTMQQLYSLEVSIVSSLVLSGIGTDTIYFLEGIHENHQMPPEGPVSAVVMRSLTEALPENRLSRLLHKHKFTEAESFAIQFGLDVELVYKVKANTILEKLASASIGSYGQEVLLDYVNEAKENLHKIQDSQFVVDYCINAPWPLYETAQEMLNYAKVRILKKDDRTIVSPSDGTLVSLTEQVLRAQARLTTFYGAFGLEKFSGIAWTEFLNNEDVLKNILFQLEEGNLSCAQYLWLRHQADFEDTFDEKMLESLLNAIHVTVPLKELCLWLKNVVIPFLRRVVPKGQKVLAKWLEQGARNLELTDKANWPENGLQMAEIFFTSKNQDEMHLTSFGQWTPLKCSDCEEVHRLKKLVNDLQELTDLYRKYNCRLALCDFEKENTTTIVFRMFDKILAPELVPSILDKFIKPYLCEHNLQKDELLLQYIKDLLERCRTRSASVFETAWEAKAIAVTGCISDTDLKFDAVLQIMHGAVVPWSGAVEQLVKQHLEMNHVKVKLLQESYRLMEMKKLLRAYGIRDTNLLKDKEMIMRLVKYILKQDTPTSLEDALKMVEAYMLPTTEVYILRMIDLIDKERGEESLTLLKSLTTAEAEKVAERLTVWGRLVLQRKADNSEEQKTQMFMTKTLVEILKFLYKIQKDNPLKKDECEANLKTFNTLATLQEDFNIFLSVEDFGNPTLMSTLLEKHISAYETDKYPSKSRQEQTMNCKTKDGKLKNCSTESRLYRMALLLQRSEQELGTTLALRALGAGRVEDAVKICRNFYKNHCNKETGKLLFSTCQRLCHMLGGDVPMNTPEDMNLPAVIYEMACQAATICSPDLLLDSLELCKYTLAAKEIYRQCQIENYGFTAKTTCFGGDKDPYEEWTYNDFFNEDGIVLDSQIVLPVIYETISSLLPISENKLYPLDSTSLANCTFIRGQNLLLPARTPICAVLQNLMECSQCELALRLMVSSFGSCLQHGISNNMDLSLSEKLHDGNIQAETKSFLIAMKQTTASIITTSIMTLLHKVFNCRLIDQNLALGYCAILPREDMFNKLWGVINNTWQNYRKVLSVALVGAQLATQYGEAAEEKKFRELITDAEWGIQLGKFGISFETVFRQPPVRKKELIRTLVQNPEVGTDLILNYCRTFMLDSDAALQLCIETLLLKNANRNHAEDDSAEYSEKQSHYTLLARALEIIPLLKSTNDLVTSLSGILYKLDPYDYETIEIVLKVIQNADERNTSIHLNQALSLLKHLESYKRISPPVDLEHQYVSEHTIPLSPASETRLPFHLIFFRTAQCFWNIISAELSEESFPTLLLISKLMKVSLDTLHMSAAQHVFQKKLKPKIFEMRNTGYTSVVNKETTKTVQTIQSYLLSIINPEWAVAMAHKIAQEFPTGPDQIQALKFCLRLAEKWLKNTTAKDESHEKAEVLQKKLYMQYKRSATENVLITYKLNTAEYLKSIAKPANLIVLLYEHHSIDQRIQNPTGRDYPDIHMAAKEIAEINNLDMNKILNQLLNKWLCPNTLPSEKTQEIFADAQEDEELRRVIYLLQSHPMDYSSRMLFAITTSATSPIGINQLTFAHRSRALKCLLYLADTNTVESLFKKPIQKVKYFLKCFIYLAEFEVLNIPYTYESFHKSPKEGMIKGLWKNHSHEPTAVRLVTELSLEYKVYDFQLWNGLLQKLLGFNMIHYLRKVLIAITGIHSLWQIPSFSRAWRSVVLSPFLTASCPPSPKQIEECCECFVILLKCPVLADLDVIGIAKQYAQLDLPAFALGCLMLIPQSEKREQQIQAFLSTCNTETVLQQIDEHMNTGEVVAFASQIRSLILDSIINEKLYEKISKTKYFPLVKQQLMSTHRMKELVDYFANKNCIEDAAALIREYQEKYGNPTLLDKSSSDILKMYLNGPQETCVLELSSMKS", "length": 2235 }, "evidence": [ { "id": "E1BBQ0", "url": "https://omabrowser.org/oma/group/E1BBQ0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P50748-1", "protein_name": "Kinetochore-associated protein 1", "gene_name": "KNTC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWNDIELLTNDDTGSGYLSVGSRKEHGTALYQVDLLVKISSEKASLNPKIQACSLSDGFIIVADQSVILLDSICRSLQLHLVFDTEVDVVGLCQEGKFLLVGERSGNLHLIHVTSKQTLLTNAFVQKANDENRRTYQNLVIEKDGSNEGTYYMLLLTYSGFFCITNLQLLKIQQAIENVDFSTAKKLQGQIKSSFISTENYHTLGCLSLVAGDLASEVPVIIGGTGNCAFSKWEPDSSKKGMTVKNLIDAEIIKGAKKFQLIDNLLFVLDTDNVLSLWDIYTLTPVWNWPSLHVEEFLLTTEADSPSSVTWQGITNLKLIALTASANKKMKNLMVYSLPTMEILYSLEVSSVSSLVQTGISTDTIYLLEGVCKNDPKLSEDSVSVLVLRCLTEALPENRLSRLLHKHRFAEAESFAIQFGLDVELVYKVKSNHILEKLALSSVDASEQTEWQQLVDDAKENLHKIQDDEFVVNYCLKAQWITYETTQEMLNYAKTRLLKKEDKTALIYSDGLKEVLRAHAKLTTFYGAFGPEKFSGSSWIEFLNNEDDLKDIFLQLKEGNLVCAQYLWLRHRANFESRFDVKMLESLLNSMSASVSLQKLCPWFKNDVIPFVRRTVPEGQIILAKWLEQAARNLELTDKANWPENGLQLAEIFFTAEKTDELGLASSWHWISLKDYQNTEEVCQLRTLVNNLRELITLHRKYNCKLALSDFEKENTTTIVFRMFDKVLAPELIPSILEKFIRVYMREHDLQEEELLLLYIEDLLNRCSSKSTSLFETAWEAKAMAVIACLSDTDLIFDAVLKIMYAAVVPWSAAVEQLVKQHLEMDHPKVKLLQESYKLMEMKKLLRGYGIREVNLLNKEIMRVVRYILKQDVPSSLEDALKVAQAFMLSDDEIYSLRIIDLIDREQGEDCLLLLKSLPPAEAEKTAERVIIWARLALQEEPDHSKEGKAWRMSVAKTSVDILKILCDIQKDNLQKKDECEEMLKLFKEVASLQENFEVFLSFEDYSNSSLVADLREQHIKAHEVAQAKHKPGSTPEPIAAEVRSPSMESKLHRQALALQMSKQELEAELTLRALKDGNIKTALKKCSDLFKYHCNADTGKLLFLTCQKLCQMLADNVPVTVPVGLNLPSMIHDLASQAATICSPDFLLDALELCKHTLMAVELSRQCQMDDCGILMKASFGTHKDPYEEWSYSDFFSEDGIVLESQMVLPVIYELISSLVPLAESKRYPLESTSLPYCSLNEGDGLVLPVINSISALLQNLQESSQWELALRFVVGSFGTCLQHSVSNFMNATLSEKLFGETTLVKSRHVVMELKEKAVIFIRENATTLLHKVFNCRLVDLDLALGYCTLLPQKDVFENLWKLIDKAWQNYDKILAISLVGSELASLYQEIEMGLKFRELSTDAQWGIRLGKLGISFQPVFRQHFLTKKDLIKALVENIDMDTSLILEYCSTFQLDCDAVLQLFIETLLHNTNAGQGQGDASMDSAKRRHPKLLAKALEMVPLLTSTKDLVISLSGILHKLDPYDYEMIEVVLKVIERADEKITNININQALSILKHLKSYRRISPPVDLEYQYMLEHVITLPSAAQTRLPFHLIFFGTAQNFWKILSTELSEESFPTLLLISKLMKFSLDTLYVSTAKHVFEKKLKPKLLKLTQAKSSTLINKEITKITQTIESCLLSIVNPEWAVAIAISLAQDIPEGSFKISALKFCLYLAERWLQNIPSQDEKREKAEALLKKLHIQYRRSGTEAVLIAHKLNTEEYLRVIGKPAHLIVSLYEHPSINQRIQNSSGTDYPDIHAAAKEIAEVNEINLEKVWDMLLEKWLCPSTKPGEKPSELFELQEDEALRRVQYLLLSRPIDYSSRMLFVFATSTTTTLGMHQLTFAHRTRALQCLFYLADKETIESLFKKPIEEVKSYLRCITFLASFETLNIPITYELFCSSPKEGMIKGLWKNHSHESMAVRLVTELCLEYKIYDLQLWNGLLQKLLGFNMIPYLRKVLKAISSIHSLWQVPYFSKAWQRVIQIPLLSASCPLSPDQLSDCSESLIAVLECPVSGDLDLIGVARQYIQLELPAFALACLMLMPHSEKRHQQIKNFLGSCDPQVILKQLEEHMNTGQLAGFSHQIRSLILNNIINKKEFGILAKTKYFQMLKMHAMNTNNITELVNYLANDLSLDEASVLITEYSKHCGKPVPPDTAPCEILKMFLSGLS", "length": 2209 }, "evidence": [ { "id": "E1BBQ0", "url": "https://omabrowser.org/oma/group/E1BBQ0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C3Y4-1", "protein_name": "Kinetochore-associated protein 1", "gene_name": "Kntc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWNNIELLTSDDTGSGCLSVGSRKENVTALYQADLLGKISSEKTSLSPKIQAFSLSHGFIIVADQSVILLDSICRSLQLFLIFDTDVDVVGLCQEGKFLFVGERSGNFHLIYVTSKQTLFTKAFVEKALDESQRTYRNLIIEKDGSNEGTYYMLLLTNNGFFYITNLQLSQIEQAIENTDLDSAKKLQGQFKCSFISTENYHSCLSLVASQSGTFASKTSVIIGGTGSCAFSKWEPDSTKKEMSLKNFVGTDIIKGAKSFQLIDNLLFVLDTDNVLSLWDAYTLTPVWNWPSLPVEQFVLTTEADSPSSVTWQGITNLKLVTLTATAKEKMRSLIIYSLPSMETLYSLEVSSVSSLVQTGISTDTIYLLEGIHKNDPNLCEDSVSDLVLRYLTEVLPENRLSRLLHKHRFAEAESFAIQFGLDVELVYKVKSNDMLEKLALISSDKSEQSKWQQLVDEAKENLCKIQDDDFVVNFCLKAQWVTYETTQEMLSYAKTRLMKKEDRALPASSDAFMEVLKAHAKLTTFYGAFGPEKFSGSSWIEFLNNEDDLRDVFLQLSEGNFACAQYLWLRHRADFESKFDVKMLENLLNSISTQFPLENLCSWFKNEVIPFVRRIVPEGQNILAKWLEQASRNLELTDKANWPENGLQLAEVFFTAEKTDRFGFASSWHWISLDYQNTEEVRQLRTLVSKLRELIILHRKYNCKLALSDFEKENATTVVFRMFDRVSAPELIPSVLEKSVRVYIREQNLQEEELLLLYIEDLLKRCSSKSMTLFDTAWEAKAMAVIRCLSDTDLIFDAVLKIMYKAVVPWSAAVEQLVKQHLEMDHPKVKLLQESYKLMEMKKLLRGYGIREVNLLNKEIMRVIRYILKQDIPSSLEDALKVAQGYRLSDDEIYSLRIIDLIDREQGGDCLLLLKSLPAAEAEKTAERVIIWARLALQEEPDGSEEDKAWRISVAKTSVDILKILCDIRKDNLQKKDESEEFLKRFQMVASLQENFEVFLPFEDYSNTALVAGLREQYIKAQEAAQAEHKHRGPPGPTPARGTHLSIKSKLHRQALALQVSEQELEAELTLRALKDGKVVAALSKCRDLLKHYCNADTGRLLFVVCQKLCQMLADDVPMVAPGGLSLPSEIHDLACHAVTICSPDYLLDVLELSKYTLTAVELCRQCQMDDCGMLMKAALGTHKDPYEEWSFSDFFSEDGIVLESQVVLPVIYELISSVMPPAESKRHPLDSISLPYCSTSEGENRILPLVSSISALLRSLQECSQWELALRFVVGSFGTCLQHSMSNVMSISLSKQLLGKNTLANSRHIIMELKEKSITFIRENATTLLHKVFNCRVVDLDLALAYCTLLPQKDVFDNLWKFIDKAWQNYDKILALSLVGSQLANLYQDIETGLWFHELSIDAKWGIRLGKLGISFQPAFRQNFLTKKDLIKALVNNIDMDTSLILEYCSTFQLDSDAALRLFIETLLRNTSSQSQGDAAPESTKHQHSKLLAKATELVPLLKNTKDLVISLSEILYKLDPYDYEMIDVVLKVLEQANEKITSVNINQALNLLRHLKSYRRISPPVDHEYQYALEHMITLPPAAHTRLPFHLILFGTAQNFWKILSSELSEESLPTLLLIAKLMKFSLDTLYVSTAKHLFEKNLKPKLLKSAQARSSTLMSKEVDKLMQTLESYLLSIVNPEWAVAIAISLTQEVPEGPFKMSSLKFCLYLAERWLQNIPPQDETCEKAKALQKKLCLQVRLSGTEAVLIAHKLNDQEYLRVIGKPAHLIVSLYEHPSISERLCTTSGKDYPDIHTAAKEIAEVNEVNLEKIWDMLLEKWLCPSTVPSEKASEFFELEEDEVLHRVVYLLQARPVDYCSRMLFVFATSATSTLGMRQLTFAHKARALQCLLYLADKETIESLFKKPIKEMKSYLKCITFLASFETLNIPITYELFCNSPKEGMIKGLWKNHSHEPMAVRLVAELCLEYKIYDLQLWNGLLQKLLGFNMIPYLRKVLSCISSIHSLWQVPYFSKAWQRVIQIPLLSASCPLRPSQLADCCDSLVAILECPVSDDLDMMGVAKQYVQLDLPAFALTCLTLMPHSEKRHQQIKNFLNSCDARIILQQIEEHMNTGQLAGFSHQIGSLVLNHVVNKKEFGILAKTKYFQLLKCHVINTGNVTELVNYLANDFSVDEASALINEYSKHCGKPVPADAAPCEILQTFLGGS", "length": 2207 }, "evidence": [ { "id": "E1BBQ0", "url": "https://omabrowser.org/oma/group/E1BBQ0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9V9W7-1", "protein_name": "Rough deal", "gene_name": "rod", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MWSNFEASSLEDETISNIFSSRGIFQISSEEEVNKYPDVMASVQCGKMVIGIDKSLLLLEDELVAKCSFLAFGAAIEAIAISSSGNLIVCGLSDGEVHGVFIKGLLLFSVAVNLEDVSLTGGTFRSIHQLDQRFYFTCKNGSIYSLSDIDETCLETLGNMSLNENETIACEKALLEDVTIQRLSKGRSSCSVDCAVLLKRLLTGNISAENNQDDLEAQPGLVITGDQSTMNFRNAANDVTRINLPAQYGSLKQIFNLEHYIIALTDSGHLVEICPYTRTVYMCQTTQQKNLLIEDLLVMECSEDNIELLVLTKSTAEGRFIKIVEYPTLNVKNEVEVPDHAWLVRQPKCAVNLYYLAAKEVNQSSIPSVVEMMLVSETDPSDRFKKLICKGRLEEAEEFGKQFELCLQPIYEAKAKRILVELCNSNSQNVDTKFQDLLQLLSQVESKAFIKSHRMINLNSRHILERYLHEVKKRLTFEDDEEDMLEIDEQLHRLKTLAIIDPYECNTDWQKFIYDNNLVRMVKSLFNTDMPTACLIWRRHSSSILPLLNEDELRTLLGFIPSNTKPFNVVQWLRQFIPMVSNTHPSIMPFITDWSIEMTRNLQYSPHWPDIGLEFCTKILDIFEEIQFTYSDVRRQQERNVGKLRDLVNALQDLSVLKTNYNMGFTLDNYMQDSIDATALSILQHVQLDKLQRLVKNFMYPIFQEKGRQPLDVIKQYISQLVASRLSSSSWLDRAMACIELLHNEDSRLECALSVLQNAPVPWPDTLAPLIRLRASTHPLAVKINAEYEIQVIKIMKVKYGWPADSSDINLELFMMRIVKLNLPDMLDDISALTKAAPELSTSANFNCCYQMARRGQVEMAYEFFKKLNGEKNSKSAKEVVEIMANILENSSSASFESDIKVQEHLNVLELFKLFLPHVESVYERRYLVIKHRFRLRKFGILLSCSSELIPLHRRHCLLDEAIERIIERAQATLNVSAFIASEISELCTALGLPKVFGLHRICQRIGCLPLSCALAYHVVSFVDCVPANAGEFVNLALELLVQQIESAKGKNQETASSLQLINENDPLSFYLAYELLTSALLHESSRRHDLVELIKYIRVAVIHYPLDAIKSHYDGKEQAVNEHICRALDGISVALGETTINFSCALNGSFDVKTLTVPTTTKKRYSVSMFDEVEVQPIQQQPQKKSVGGRMAIVKFLARTLLLMVIETEPNNSLLMQVRNELPENTKADVESACADFFLSLEHLTKVKEHDAWYVMSQYLLDFQKQNCRTKRIINEGFITLQLRRIFRNAMGSKDVNFIELFTMLVVDSEALALLEKLSVEVKTDLQKINFLTLSAMYHEHIEDLDSVHMIRTKRLKLFYYLEFCQQDHRIKGKFNADMDNIEDLLKEFHNKQLDVQLLERMSKDFGFDYQKILITQILSILSAQELRFEVKRDTFGDEELVMLSSAQEMRDMCQPYINEINNVELFTSKLKHFIEDINIYFYELYMCVINILMYFDSAPKEMEIWMNILHFLRHKMITRRRNRPGQVETDTWLKSQRENGVMPKISRYRLPFKPIVEQPLKDILDSELNVDNCQSWFPLIQMYTALKGSKDSSQNCDYFCMSAVKNSISEYKSKNDSESWSLHPTNNAFLQSILRLVEKVNNPNKAFLILYFVSNYARDGADQVEASYECWKFVKEKGHLITDPKSREQVAKVKRRYPIQKTQHLLYVYGLTDEKLLRQVENPTELIQALYHHELILKSSKVDINALVAEIAKLHDLCLATIQYRLLQKWLALTMESAGDGTILEETFMEEQNWPEQANGAESSNSQDASENVNRAFYILSSWPKAEAVKFLVGLIFKGGSVNTSTQLQMYECYSKLNDGSNSFTNTISQRQFISIKCVHELKALGYKSNLEKFSDDHCNKIDILKMIWQRNAQNPLSLEVMANICLGFDIHLPQIWNGILKRMVMFHMVRELNALLDVLSCRPHLLHLDGLAQAWDYVLCHPLQNAVELRSFKQEEVLHKTLLRLQGCPVVHALNLLQFAQLCIVVHRPHMAASLLSFCQSSEQRQKIKKMIHSHPVENLRQQILDLEDAGILPVVLNFALKELNL", "length": 2089 }, "evidence": [ { "id": "E1BBQ0", "url": "https://omabrowser.org/oma/group/E1BBQ0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "kinetochore microtubule", "id": "GO:0005828", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005828", "evidence": [ { "database": "UniProtKB", "id": "E1BBQ0", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0" } ], "pmid": "" }, { "name": "RZZ complex", "id": "GO:1990423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990423", "evidence": [ { "database": "UniProtKB", "id": "E1BBQ0", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0" } ], "pmid": "" }, { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "E1BBQ0", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BBQ0", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BBQ0", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein localization to kinetochore involved in kinetochore assembly", "id": "GO:1903394", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903394", "evidence": [ { "database": "UniProtKB", "id": "E1BBQ0", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0" } ], "pmid": "" }, { "name": "mitotic spindle assembly checkpoint signaling", "id": "GO:0007094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007094", "evidence": [ { "database": "UniProtKB", "id": "E1BBQ0", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0" } ], "pmid": "" }, { "name": "mitotic sister chromatid segregation", "id": "GO:0000070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000070", "evidence": [ { "database": "UniProtKB", "id": "E1BBQ0", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "E1BBQ0", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1289, "end_pos": 1291, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1323, "end_pos": 1325, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1471, "end_pos": 1473, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1950, "end_pos": 1952, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2156, "end_pos": 2158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2202, "end_pos": 2204, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0" }, { "id": "PF24506", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24506" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KNTC1 N-terminal", "eco_id": "ECO_0000259", "start_pos": 18, "end_pos": 393, "start_aa": "Leu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BBQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0" }, { "id": "PF24520", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24520" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KNTC1 first ARM-repeats", "eco_id": "ECO_0000259", "start_pos": 402, "end_pos": 647, "start_aa": "Arg", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BBQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0" }, { "id": "PF24516", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24516" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KNTC1 second ARM-repeats", "eco_id": "ECO_0000259", "start_pos": 751, "end_pos": 915, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BBQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0" }, { "id": "PF24515", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24515" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KNTC1 third ARM-repeats", "eco_id": "ECO_0000259", "start_pos": 1323, "end_pos": 1532, "start_aa": "Asn", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BBQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBQ0" }, { "id": "PF10493", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10493" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RZZ complex subunit KNTC1/ROD C-terminal", "eco_id": "ECO_0000259", "start_pos": 1578, "end_pos": 2126, "start_aa": "Ile", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1289, "end_pos": 1291 }, { "start_pos": 1323, "end_pos": 1325 }, { "start_pos": 1471, "end_pos": 1473 }, { "start_pos": 1950, "end_pos": 1952 }, { "start_pos": 2156, "end_pos": 2158 }, { "start_pos": 2202, "end_pos": 2204 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B725-1", "uniprot_ac": "E1B725", "uniprot_id": "E1B725_BOVIN", "mass": { "chemical_mass": 49795.0, "monoisotopic_mass": 49795.0 }, "refseq": { "ac": "NP_001179665", "name": "alpha-galactosidase A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179665" }, "gene_names": [ { "name": "GLA", "type": "recommended", "evidence": [ { "id": "E1B725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ] }, { "name": "GLA", "type": "synonym", "evidence": [ { "id": "NP_001179665", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179665" } ] } ], "protein_names": [ { "name": "Alpha-galactosidase", "type": "recommended", "evidence": [ { "id": "E1B725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B725/entry#names_and_taxonomy" } ] }, { "name": "3.2.1.-", "type": "synonym", "evidence": [ { "id": "E1B725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B725/entry#names_and_taxonomy" } ] }, { "name": "alpha-galactosidase A", "type": "synonym", "evidence": [ { "id": "NP_001179665", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179665" } ] } ], "function": [ { "annotation": "Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome.", "evidence": [ { "database": "UniProtKB", "id": "E1B725", "url": "https://www.uniprot.org/uniprotkb/E1B725#function" }, { "database": "UniProtKB", "id": "ARBA00056170", "url": "https://www.uniprot.org/uniprotkb/ARBA00056170#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B725", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GLA", "url": "https://www.uniprot.org/uniprotkb/E1B725", "locus": { "chromosome": "X", "start_pos": 50814062, "end_pos": 50803846, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019256", "url": "https://www.ensembl.org/id/ENSBTAG00000019256" } ] } } ], "crossref": [ { "id": "E1B725", "url": "https://alphafold.ebi.ac.uk/entry/E1B725", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019256", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019256", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14792", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14792", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532742", "url": "https://www.ncbi.nlm.nih.gov/gene/532742", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000111", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000111", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002241", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002241", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013780", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013780", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035373", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035373", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532742", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532742", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MTPTMGW", "url": "https://omabrowser.org/oma/group/MTPTMGW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B725", "url": "https://www.orthodb.org/?gene=E1B725", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11452", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11452", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11452:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11452:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17450", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17450", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9840310", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9840310", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179665", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "21112", "url": "https://www.rhea-db.org/rhea/21112", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "48020", "url": "https://www.rhea-db.org/rhea/48020", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S5C7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5C7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B725", "url": "https://www.uniprot.org/uniprotkb/E1B725", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B725-1", "url": "https://www.uniprot.org/uniprotkb/E1B725-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMTATMKPVSRVLRLGCVLAFCFQVLVPYGLPRAWGLDNGLAMTPTMGWLHWERFMCNVNCQEEPDSCISEKLFLQIAEIMASDGWKDVGYEYICIDDCWMAPERDSKGRLQADPKRFPGGIHRLADYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSIQHLAEGYKQMSLALNRTGRSIVYSCEWPLYVWPIFKPNYTEIREYCNHWRNFADIYDSWESIRKTLDWTSSNQKIIVPVAGPGGWNDPDMLVIGNFGLSRDQQITQMALWAIMAAPLLMSNDLRHISPEAKALLQDKDVIAINQDRLGKQGYWLRKEDNFEMWERPLLNLAWAVAIVNLQEIGGPRSYTISVTSLGRGLACNPNCLITELLPEKRKLGIYEWTSTLKTQINPTGTVLLRLETTSSAQFSHSVVSDFL", "length": 439, "header": "tr|E1B725-1|E1B725_BOVIN Isoform 1 of Alpha-galactosidase OS=Bos taurus OX=9913 GN=GLA PE=3 SV=2 CANONICAL=E1B725-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5C7-1", "url": "https://www.uniprot.org/uniprotkb/E1B725/entry#A0AAA9S5C7-1", "sequence": { "sequence": "MKPVSRVLRLGCVLAFCFQVLVPYGLPRAWGLDNGLAMTPTMGWLHWERFMCNVNCQEEPDSCISEKLFLQIAEIMASDGWKDVGYEYICIDDCWMAPERDSKGRLQADPKRFPGGIHRLADYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSIQHLAEGYKQMSLALNRTGRSIVYSCEWPLYVWPIFKPNYTEIREYCNHWRNFADIYDSWESIRKTLDWTSSNQKIIVPVAGPGGWNDPDMEDNFEMWERPLLNLAWAVAIVNLQEIGGPRSYTISVTSLGRGLACNPNCLITELLPEKRKLGIYEWTSTLKTQINPTGTVLLRLETT", "length": 354, "header": "tr|A0AAA9S5C7-1|E1B725_BOVIN Computationally mapped isoform of Alpha-galactosidase OS=Bos taurus OX=9913 GN=GLA PE=3 SV=1 CANONICAL=E1B725-1" }, "locus": { "chromosome": "X", "start_pos": 50813482, "end_pos": 50803948, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113977.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113977.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078439.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078439.1" } ] } }, { "isoform_ac": "E1B725-1", "url": "https://www.uniprot.org/uniprotkb/E1B725/entry#E1B725-1", "sequence": { "sequence": "MMTATMKPVSRVLRLGCVLAFCFQVLVPYGLPRAWGLDNGLAMTPTMGWLHWERFMCNVNCQEEPDSCISEKLFLQIAEIMASDGWKDVGYEYICIDDCWMAPERDSKGRLQADPKRFPGGIHRLADYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSIQHLAEGYKQMSLALNRTGRSIVYSCEWPLYVWPIFKPNYTEIREYCNHWRNFADIYDSWESIRKTLDWTSSNQKIIVPVAGPGGWNDPDMLVIGNFGLSRDQQITQMALWAIMAAPLLMSNDLRHISPEAKALLQDKDVIAINQDRLGKQGYWLRKEDNFEMWERPLLNLAWAVAIVNLQEIGGPRSYTISVTSLGRGLACNPNCLITELLPEKRKLGIYEWTSTLKTQINPTGTVLLRLETTSSAQFSHSVVSDFL", "length": 439, "header": "tr|E1B725-1|E1B725_BOVIN Isoform 1 of Alpha-galactosidase OS=Bos taurus OX=9913 GN=GLA PE=3 SV=2 CANONICAL=E1B725-1" }, "locus": { "chromosome": "X", "start_pos": 50813524, "end_pos": 50803933, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025636.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025636.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025636.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025636.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:532742", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532742", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-BTA-9840310", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9840310", "resource": "Reactome", "description": "Glycosphingolipid catabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B636-1", "protein_name": "Alpha-galactosidase", "gene_name": "GLA", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTATMKPVSRVRRLGYVLPFCFLAQVLWGVPGARALNNGLARTPTMGWLHWERFMCNVDCQEDPDSCISEKLFRQIAELMASDGWKDAGYEYLCIDDCWMAPKRDSQGRLQADPKRFPGGIRRLADYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAKTFAEWGVDLLKFDGCYCDSVKHLADGYKQMSLALNRTGRSIVYSCEWPLYMQPFFKPNYTEIREYCNHWRNFADIYDSWQSIKNILDWTSSNQEKIVPVAGPGGWNDPDMLVIGNFGLSWNQEVTQMALWAIMAAPLLMSNDLRHISPKAKALLQDKDVIAINQDPLGKQGHRLRKDNNFEVWERPLLNLAWAVAMVNLQEIGGPRAYTISLTSLGQGLACNPDCLITQLLPVKRRLGFYEWTSSLKTQINPTGTVLLRLERASSTASKSFL", "length": 433 }, "evidence": [ { "id": "E1B725", "url": "https://omabrowser.org/oma/group/E1B725/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YVV2-1", "protein_name": "Alpha-galactosidase", "gene_name": "GLA", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAAAARWALVAAVVVALAVALDNGVARTPPMGWLHWERFLCGTDCAAEPDRCVSERLFTEMADVMVAEGWKEAGYEFVCIDDCWMAPTRDERGRLRADPRRFPSGIRALADYVHSKGLKLGIYSDVGNTTCAGFPGSYGHYELDAQTFASWGVDLLKFDGCNADSLELLAEGYRNMSLALNKTGRPIVYSCEWPFYLRPMQQPNYTEIKQYCNHWRNFYDVYDSWNSIKSIMEWTALHQDSIVKIAGPGGWNDPDMLVIGNFGLSWEQAVTQMAMWAIMAAPLFMSNDLRHMKPEAKWLLQNKEVIAINQDPLGKQGYRITKDKNFELWERPLSDRAYAVAVLNQQEIGGPQNFTFSLTFLGNGLACNPACCIQQILPTSRDWGVHNWVSSLSVEVNPTGTVLLKLVPL", "length": 410 }, "evidence": [ { "id": "E1B725", "url": "https://omabrowser.org/oma/group/E1B725/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0LNX9-1", "protein_name": "Alpha-galactosidase", "gene_name": "Gla", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAMKLLSGDTPLVCELALRPLALVFWSILGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDACISEQLFMQMAELMVSDGWRDAGYEYLCIDDCWMAPERDSKGRLQADPKRFPSGIKHLANYVHSKGLKLGIYADVGKKTCAGFPGSFGSYDIDAQTFADWGIDLLKFDGCHCDSVVSLANGYKYMSLALNRTGRSIVYSCEWPLYLRPFHKPNYTDIQYYCNHWRNFDDVYDSWESIKSILAWTVTHQKDIVEVAGPGGWNDPDMLVIGNFGLSWDQQVTQMALWAIMAAPLLMSNDLRQISSQAKALLQNEDVIAINQDPLGKQGYCFRKENEIEVWERPLSNLAWAVAVRNLQEIGGPRFYTIQISSLGRGLACNPGCIITQILPEKVHLGFYEWPLTLKTRINPSACPTGVNHYNW", "length": 423 }, "evidence": [ { "id": "E1B725", "url": "https://omabrowser.org/oma/group/E1B725/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1Q5G5-1", "protein_name": "Alpha-galactosidase", "gene_name": "gla", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRASIIVVIGLVCLLVPAAALDNGLALTPTMGWLHWERFMCNTDCDADPQNCIREELFMQMADVMVKEGWKDAGYEFVCIDDCWPSQQRDAQGRLQADPKRFPSGIKKLADYVHSKGLKLGIYADVGTKTCAGYPGSLGYYDIDAKTFADWGVDLLKFDGCFMPDWHQLGEGYINMSSALNQTGRSIVYSCEWPLYEWQHQQPDYEAIRKTCNHWRNYGDVYDQWTSVKSILDWTAEKQKIVVPVAGPGGWNDPDMLIIGNFGLSRDQQQTQMALWAIMAAPLLMSNDLRDICPKAKELLQNKQIIAINQDPLGKQGYRILKADSFELWERPLSGNRLAVAVMNRQEIGGPRRFTISVAIMPSWKLCNPKCNVTQIMPTYKEMGVQNLLSEVVVQVNPTGTTLLTVNPL", "length": 409 }, "evidence": [ { "id": "E1B725", "url": "https://omabrowser.org/oma/group/E1B725/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P06280-1", "protein_name": "Alpha-galactosidase A", "gene_name": "GLA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENTMQMSLKDLL", "length": 429 }, "evidence": [ { "id": "E1B725", "url": "https://omabrowser.org/oma/group/E1B725/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P51569-1", "protein_name": "Alpha-galactosidase A", "gene_name": "Gla", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKLLSRDTRLVCELALCPLALVFWSILGVRALDNGLARTPTMGWLHWERFMCNLDCQEEPDACISEQLFMQMAELMVSDGWRDAGYDYLCIDDCWMAPERDSKGRLQADPQRFPSGIKHLANYVHSKGLKLGIYADVGNKTCAGFPGSFGSYDIDAQTFADWGVDLLKFDGCHCDSVVSLENGYKYMALALNRTGRSIVYSCEWPLYLRPFHKPNYTDIQYYCNHWRNFDDVYDSWESIKNILSWTVVYQKEIVEVAGPGSWNDPDMLVIGNFGLSWDQQVTQMALWAIMAAPLLMSNDLRQISSQAKALLQNKDVIAINQDPLGKQGYCFRKENHIEVWERPLSNLAWAVAVRNLQEIGGPCPYTIQISSLGRGLACNPGCIITQLLPEKVHLGFYEWTLTLKTRVNPSGTVLFRLER", "length": 419 }, "evidence": [ { "id": "E1B725", "url": "https://omabrowser.org/oma/group/E1B725/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q55B10-1", "protein_name": "Probable alpha-galactosidase", "gene_name": "melA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MMKIAATLLATIALATVNALDNGLALTPQMGWSSWNFYACNINESVIMNTAKAMVSNGMADAGYTYVNIDDCWAGGRYPNGTVYADPTNFPNGIKYVADYIHSLGLKIGIYTDAGTETCQKRVGSYGYEANDAQTYAEWGIDYVKEDWCYATLENPQQRYQIMSQALNATGRPMFFSLCDWGYENPWTFGMSVGNSWRTTPDIKDNWDSMLSNLMAQAPITSFSGIGGFNDPDMMMVGNGGMSNTEYVSHFSLWSLLNAPLIAGCDLIDIDQETLSILTASEVIAINQDPLGVQGSLVKSYNGGLQQIWAKPLSNGARAVVLFNTDTNPATIELLWGNIWMEPSQQLSIRNLWTQTNLGTFTESYESDSLIPPHGCIMLTLTPTN", "length": 385 }, "evidence": [ { "id": "E1B725", "url": "https://omabrowser.org/oma/group/E1B725/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9FT97-1", "protein_name": "Alpha-galactosidase 1", "gene_name": "AGAL1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSRRAMVIKMPILMILISSMVMTMVESSRSVNNGHDDSEILRRHLLTNGLGVTPPMGWNSWNHFSCNIDEKMIKETADALVTTGLSKLGYNYVNIDDCWAEISRDSKGSLVPKKSTFPSGIKAVADYVHSKGLKLGIYSDAGYFTCSKTMPGSLGYEEHDAKTFAEWGIDYLKYDNCNSDGSKPTVRYPVMTRALMKSGRPIFHSLCEWGDMHPALWGSPVGNSWRTTNDIKDTWLSMISIADMNEVYAEHARPGGWNDPDMLEVGNGGMTKDEYIVHFSIWAISKAPLLLGCDIRNMTKETMEIVANKEVIAINQDPHGVQAKKVRMEGDLEVWAGPLSGYRVALLLLNRGPSRTSITALWEDIEIPANSIVEARDLWEHQTLKQKFVGNLTATVDSHACKLYVLKPVA", "length": 410 }, "evidence": [ { "id": "E1B725", "url": "https://omabrowser.org/oma/group/E1B725/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "hydrolase activity, hydrolyzing O-glycosyl compounds", "id": "GO:0004553", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004553", "evidence": [ { "database": "UniProtKB", "id": "E1B725", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ], "pmid": "" }, { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "E1B725", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "E1B725", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ], "pmid": "" }, { "name": "alpha-galactosidase activity", "id": "GO:0004557", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004557", "evidence": [ { "database": "UniProtKB", "id": "E1B725", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "E1B725", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ], "pmid": "" }, { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "E1B725", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ], "pmid": "" }, { "name": "oligosaccharide metabolic process", "id": "GO:0009311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009311", "evidence": [ { "database": "UniProtKB", "id": "E1B725", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ], "pmid": "" }, { "name": "glycoside catabolic process", "id": "GO:0016139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016139", "evidence": [ { "database": "UniProtKB", "id": "E1B725", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ], "pmid": "" }, { "name": "glycosphingolipid catabolic process", "id": "GO:0046479", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046479", "evidence": [ { "database": "UniProtKB", "id": "E1B725", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "E1B725", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1B725", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B725", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "E1B725", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1B725", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 144, "end_pos": 146, "annotation": "n_glycosylation_sequon" }, { "start_pos": 197, "end_pos": 199, "annotation": "n_glycosylation_sequon" }, { "start_pos": 220, "end_pos": 222, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21112", "name": "", "equation": "a globoside Gb3Cer (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1B725-1" ], "evidence": [ { "id": "21112", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21112" } ] }, { "id": "48020", "name": "", "equation": "a globoside Gb3Cer + H2O = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1B725-1" ], "evidence": [ { "id": "48020", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48020" } ] }, { "id": "R-BTA-1605736", "name": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [], "output_participant_list": [ "R-ALL-1605637" ], "enzyme_list": [ "E1B725-1" ], "evidence": [ { "id": "R-BTA-1605736", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1605736" } ] }, { "id": "R-BTA-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, azurophil granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O77834-1", "Q29451-1", "P07514-1", "A0JNA3-1", "Q32PF2-1", "Q3MI05-1", "F1MUP9-1", "H7BWW2-1", "Q08DD1-1", "Q2KIM0-1", "Q3ZBH0-1", "F1MU24-1", "A0AAA9U1E9-1", "A0ABI0NJH4-1", "F1N144-1", "F1N5H2-1", "P80189-1", "P46196-1", "A7YWG4-1", "E1BPI3-1", "A0AAA9SWY4-1", "A0A3Q1LUG9-1", "F1MGY9-1", "G3X757-1", "A0A3Q1NDQ7-1", "Q2KJ64-1", "Q3ZCI9-1", "E1B725-1" ], "evidence": [ { "id": "R-BTA-6798751", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798751" } ] }, { "id": "R-BTA-9841189", "name": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [], "output_participant_list": [ "R-ALL-1606573" ], "enzyme_list": [ "E1B725-1" ], "evidence": [ { "id": "R-BTA-9841189", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9841189" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1605637", "participant_name": "Gal [lysosomal lumen]", "crossref": [ { "id": "28061", "database": "ChEBI", "url": "" }, { "id": "G09546QO", "database": "GlyTouCan", "url": "" }, { "id": "4646", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "HMDB0000143", "database": "HMDB Metabolite", "url": "" }, { "id": "ZINC000000901155", "database": "ZINC", "url": "" }, { "id": "C00984", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-1606573", "participant_name": "GalCer [lysosomal lumen]", "crossref": [ { "id": "36498", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LUG9", "gene_name": "TXNDC5", "activity": [ { "ec_number": "5.3.4.1", "activity": "Catalyzes the rearrangement of -S-S- bonds in proteins.", "evidence": [ { "id": "A0A3Q1LUG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9" } ] }, { "ec_number": "5.3.4.1", "activity": "", "evidence": [ { "id": "A0A3Q1LUG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9" } ] } ] }, { "uniprot_ac": "A0A3Q1NDQ7", "gene_name": "GLB1", "activity": [ { "ec_number": "3.2.1.23", "activity": "Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.", "evidence": [ { "id": "A0A3Q1NDQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDQ7" } ] }, { "ec_number": "3.2.1.23", "activity": "", "evidence": [ { "id": "A0A3Q1NDQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDQ7" } ] } ] }, { "uniprot_ac": "A0AAA9SWY4", "gene_name": "CPPED1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] } ] }, { "uniprot_ac": "A0AAA9U1E9", "gene_name": "GALNS", "activity": [ { "ec_number": "3.1.6.4", "activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.", "evidence": [ { "id": "A0AAA9U1E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1E9" } ] }, { "ec_number": "3.1.6.4", "activity": "", "evidence": [ { "id": "A0AAA9U1E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1E9" } ] } ] }, { "uniprot_ac": "A0ABI0NJH4", "gene_name": "GNS", "activity": [ { "ec_number": "3.1.6.14", "activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.", "evidence": [ { "id": "A0ABI0NJH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJH4" } ] }, { "ec_number": "3.1.6.14", "activity": "", "evidence": [ { "id": "A0ABI0NJH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJH4" } ] } ] }, { "uniprot_ac": "A0JNA3", "gene_name": "IMPDH1", "activity": [ { "ec_number": "1.1.1.205", "activity": "IMP + NAD(+) + H2O = XMP + NADH + H(+).", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] } ] }, { "uniprot_ac": "A7YWG4", "gene_name": "GGH", "activity": [ { "ec_number": "3.4.19.9", "activity": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate.", "evidence": [ { "id": "A7YWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWG4" } ] }, { "ec_number": "3.4.19.9", "activity": "", "evidence": [ { "id": "A7YWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWG4" } ] } ] }, { "uniprot_ac": "E1B725", "gene_name": "GLA", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "E1B725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ] } ] }, { "uniprot_ac": "E1BPI3", "gene_name": "FRK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] }, { "ec_number": "2.7.10.2", "activity": "", 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"Protein Classification", "Other" ] }, { "id": "PF19037", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19037", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005225595", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225595", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S5Y8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Y8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5Y8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Y8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCH7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCH7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCH7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCH7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM55", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM55-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7M9", "url": "https://www.uniprot.org/uniprotkb/E1B7M9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7M9-1", "url": "https://www.uniprot.org/uniprotkb/E1B7M9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKCVLVATESAEVLFYWTDGEFEESLRLKFGQTENEGEKPPALEDQLSTLLAPVIISSMTMLEKLSDTYTCFSTENGNYLYVLHLFGECLFIAINGDRTEGEGDLRQKLCVLKYLFEVHFGLVTVDGQLIRKELRPPDLEQRVEVWERFQSLLWTYSRLRDQEQCFAVEAVERLIHPQLCELCIEALERHVVQAINSSPGRAGEEALHAFLLVHSKLLAFYSSHNASSLRPADLLALILLVQDLYPSESTAEDSDPQPSPRRLHRSQSIPVRQAWSSCAADPTRNSAGTETDSFSPTEEYFTPAPSPGEQSSGSTIWLDGGTPPTDSPHIQMAEDTLQTLIAHSPGPSGPRRIFLDASVKDSYCPLVPHTMYCLPLWPGISMVLLTKCPSTALALALYQLLDGFSQLEKKLKEGQEAGSALRSHPIMADLRQRMDKFVKNRGGQELQKTWLEFKTKAFSKSEPGSSLELLQACRKVKRQLCAIYRFSFLTMAPGRGGPHLPQHLQDQVQTLMQEKLADWKDFLLVKSRRNVTMVSFLEDFPGLVHFIYVDRTTGQMVAPSLSSSERTSSELGRGPLATFVKTKVWSLIRLARRYLQKGYTTLLFREGDFCCSYFLWFENDMGHKLQIMEVPVLSDDSAPVGMLGGDYYRKLLRYYSKGHPAEAVRCHELLALHLSVVPTDVLVQQAGELAQRLGEASRVHLL", "length": 702, "header": "tr|E1B7M9-1|E1B7M9_BOVIN Isoform 1 of HPS1 biosis of lysosomal organelles complex 3 subunit 1 OS=Bos taurus OX=9913 GN=HPS1 PE=4 SV=3 CANONICAL=E1B7M9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5Y8-1", "url": "https://www.uniprot.org/uniprotkb/E1B7M9/entry#A0AAA9S5Y8-1", "sequence": { "sequence": "MKCVLVATESAEVLFYWTDGEFEESLRLKFGQTENEGEKPPALEDQLSTLLAPVIISSMTMLEKLSDTYTCFSTENGNYLYVLHLFGECLFIAINGDRTEGEGDLRQKLCVLKYLFEVHFGLVTVDGQLIRKELRPPDLEQRVEVWERFQSLLWTYSRLRDQEQCFAVEAVERLIHPQLCELCIEALERHVVQAINSSPGRAGEEALHAFLLVHSKLLAFYSSHNASSLRPADLLALILLVQDLYPSESTAEDSDPQETDSFSPTEEYFTPAPSPGEQSSGSTIWLDGGTPPTDSPHIQMAEDTLQTLIAHSPGPSGPRRIFLDASVKDSYCPLVPHTMYCLPLWPGISMVLLTKCPSTALALALYQLLDGFSQLEKKLKEGQEAGSALRSHPIMADLRQRMDKFVKNRGGQELQKTWLEFKTKAFSKSEPGSSLELLQACRKVKRQLCAIYRFSFLTMAPGRGGPHLPQHLQDQVQTLMQEKLADWKDFLLVKSRRNVTMVSFLEDFPGLVHFIYVDRTTGQMVAPSLSSSERTSSELGRGPLATFVKTKVWSLIRLARRYLQKGYTTLLFREGDFCCSYFLWFENDMGHKLQIMEVPVLSDDSAPVGMLGGDYYRKLLRYYSKGHPAEAVRCHELLALHLSVVPTDVLVQQAGELAQRLGEASRVHLL", "length": 670, "header": "tr|A0AAA9S5Y8-1|E1B7M9_BOVIN Computationally mapped isoform of HPS1 biosis of lysosomal organelles complex 3 subunit 1 OS=Bos taurus OX=9913 GN=HPS1 PE=4 SV=1 CANONICAL=E1B7M9-1" }, "locus": { "chromosome": "26", "start_pos": 19515932, "end_pos": 19496721, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100995.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100995.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080635.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080635.1" } ] } }, { "isoform_ac": "A0AAA9SKT9-1", "url": "https://www.uniprot.org/uniprotkb/E1B7M9/entry#A0AAA9SKT9-1", "sequence": { "sequence": "MKCVLVATESAEVLFYWTDGEFEESLRLKFGQTENEGEKPPALEDQLSTLLAPVIISSMTMLEKLSDTYTCFSTENGNYLYVLHLAAAPGLGAACGGVGALPEPAVDLQPPAGPRAVLCRRGSTIWLDGGTPPTDSPHIQMAEDTLQTLIAHSPGPSGPRRIFLDASVKDSYCPLVPHTMYCLPLWPGISMVLLTKCPSTALALALYQLLDGFSQLEKKLKEGQEAGSALRSHPIMADLRQRMDKFVKNRGGQELQKTWLEFKTKAFSKSEPGSSLELLQACRKVKRQLCAIYRFSFLTMAPGRGGPHLPQHLQDQVQTLMQEKLADWKDFLLVKSRRNVTMVSFLEDFPGLVHFIYVDRTTGQMVAPSLSSSERTSSELGRGPLATFVKTKVWSLIRLARRYLQKGYTTLLFREGDFCCSYFLWFENDMGHKLQIMEVPVLSDDSAPVGMLGGDYYRKLLRYYSKGHPAEAVRCHELLALHLSVVPTDVLVQQAGELAQRLGEASRVHLL", "length": 511, "header": "tr|A0AAA9SKT9-1|E1B7M9_BOVIN Computationally mapped isoform of HPS1 biosis of lysosomal organelles complex 3 subunit 1 OS=Bos taurus OX=9913 GN=HPS1 PE=4 SV=1 CANONICAL=E1B7M9-1" }, "locus": { "chromosome": "26", "start_pos": 19515932, "end_pos": 19496721, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110132.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110132.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085905.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085905.1" } ] } }, { "isoform_ac": "A0AAA9TCH7-1", "url": "https://www.uniprot.org/uniprotkb/E1B7M9/entry#A0AAA9TCH7-1", "sequence": { "sequence": "MKCVLVATESAEVLFYWTDGEFEESLRLKFGQTENEGEKPPALEDQLSTLLAPVIISSMTMLEKLSDTYTCFSTENGNYLYVLHLFGECLFIAINGDRTEGEGDLRQKLCVLKYLFEVHFGLVTVDGQLIRKELRPPDLEQRVEVWERFQSLLWTYSRLRDQEQCFAVEAVERLIHPQLCELCIEALERHVVQAINSSPGRAGEEALHAFLLVHSKLLAFYSSHNASSLRPADLLALILLVQDLYPSESTAEDSDPQPSPRRLHRSQSIPVRQAWSSCAADPTRNSAGTETDSFSPTEEYFTPAPSPGEQSSGSTIWLDGGTPPTDSPHIQCPSTALALALYQLLDGFSQLEKKLKEGQEAGSALRSHPIMADLRQRMDKFVKNRGGQELQKTWLEFKTKAFSKSEPGSSLELLQACRKVKRQLCAIYRFSFLTMAPGRGGPHLPQHLQDQVQTLMQEKLADWKDFLLVKSRRNVTMVSFLEDFPGLVHFIYVDRTTGQMVAPSLSSSERTSSELGRGPLATFVKTKVWSLIRLARRYLQKGYTTLLFREGDFCCSYFLWFENDMGHKLQIMEVPVLSDDSAPVGMLGGDYYRKLLRYYSKGHPAEAVRCHELLALHLSVVPTDVLVQQAGELAQRLGEASRVHLL", "length": 646, "header": "tr|A0AAA9TCH7-1|E1B7M9_BOVIN Computationally mapped isoform of HPS1 biosis of lysosomal organelles complex 3 subunit 1 OS=Bos taurus OX=9913 GN=HPS1 PE=4 SV=1 CANONICAL=E1B7M9-1" }, "locus": { "chromosome": "26", "start_pos": 19515932, "end_pos": 19496721, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125495.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125495.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095760.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095760.1" } ] } }, { "isoform_ac": "A0AAF6DM55-1", "url": "https://www.uniprot.org/uniprotkb/E1B7M9/entry#A0AAF6DM55-1", "sequence": { "sequence": "MDCSSPGSSVHGISQMKCVLVATESAEVLFYWTDGEFEESLRLKFGQTENEGEKPPALEDQLSTLLAPVIISSMTMLEKLSDTYTCFSTENGNYLYVLHLFGECLFIAINGDRTEGEGDLRQKLCVLKYLFEVHFGLVTVDGQLIRKELRPPDLEQRVEVWERFQSLLWTYSRLRDQEQCFAVEAVERLIHPQLCELCIEALERHVVQAINSSPGRAGEEALHAFLLVHSKLLAFYSSHNASSLRPADLLALILLVQDLYPSESTAEDSDPQPSPRRLHRSQSIPVRQAWSSCAADPTRNSAGTETDSFSPTEEYFTPAPSPGEQSSGSTIWLDGGTPPTDSPHIQMAEDTLQTLIAHSPGPSGPRRIFLDASVKDSYCPLVPHTMYCLPLWPGISMVLLTKCPSTALALALYQLLDGFSQLEKKLKEGQEAGSALRSHPIMADLRQRMDKFVKNRGGQELQKTWLEFKTKAFSKSEPGSSLELLQACRKVKRQLCAIYRFSFLTMAPGRGGPHLPQHLQDQVQTLMQEKLADWKDFLLVKSRRNVTMVSFLEDFPGLVHFIYVDRTTGQMVAPSLSSSERTSSELGRGPLATFVKTKVWSLIRLARRYLQKGYTTLLFREGDFCCSYFLWFENDMGHKLQIMEVPVLSDDSAPVGMLGGDYYRKLLRYYSKGHPAEAVRCHELLALHLSVVPTDVLVQQAGELAQRLGEASRVHLL", "length": 717, "header": "tr|A0AAF6DM55-1|E1B7M9_BOVIN Computationally mapped isoform of HPS1 biosis of lysosomal organelles complex 3 subunit 1 OS=Bos taurus OX=9913 GN=HPS1 PE=4 SV=1 CANONICAL=E1B7M9-1" }, "locus": { "chromosome": "26", "start_pos": 19519468, "end_pos": 19496721, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019034.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019034.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019034.7", "url": "https://www.ensembl.org/id/ENSBTAP00000019034.7" } ] } }, { "isoform_ac": "E1B7M9-1", "url": "https://www.uniprot.org/uniprotkb/E1B7M9/entry#E1B7M9-1", "sequence": { "sequence": "MKCVLVATESAEVLFYWTDGEFEESLRLKFGQTENEGEKPPALEDQLSTLLAPVIISSMTMLEKLSDTYTCFSTENGNYLYVLHLFGECLFIAINGDRTEGEGDLRQKLCVLKYLFEVHFGLVTVDGQLIRKELRPPDLEQRVEVWERFQSLLWTYSRLRDQEQCFAVEAVERLIHPQLCELCIEALERHVVQAINSSPGRAGEEALHAFLLVHSKLLAFYSSHNASSLRPADLLALILLVQDLYPSESTAEDSDPQPSPRRLHRSQSIPVRQAWSSCAADPTRNSAGTETDSFSPTEEYFTPAPSPGEQSSGSTIWLDGGTPPTDSPHIQMAEDTLQTLIAHSPGPSGPRRIFLDASVKDSYCPLVPHTMYCLPLWPGISMVLLTKCPSTALALALYQLLDGFSQLEKKLKEGQEAGSALRSHPIMADLRQRMDKFVKNRGGQELQKTWLEFKTKAFSKSEPGSSLELLQACRKVKRQLCAIYRFSFLTMAPGRGGPHLPQHLQDQVQTLMQEKLADWKDFLLVKSRRNVTMVSFLEDFPGLVHFIYVDRTTGQMVAPSLSSSERTSSELGRGPLATFVKTKVWSLIRLARRYLQKGYTTLLFREGDFCCSYFLWFENDMGHKLQIMEVPVLSDDSAPVGMLGGDYYRKLLRYYSKGHPAEAVRCHELLALHLSVVPTDVLVQQAGELAQRLGEASRVHLL", "length": 702, "header": "tr|E1B7M9-1|E1B7M9_BOVIN Isoform 1 of HPS1 biosis of lysosomal organelles complex 3 subunit 1 OS=Bos taurus OX=9913 GN=HPS1 PE=4 SV=3 CANONICAL=E1B7M9-1" }, "locus": { "chromosome": "26", "start_pos": 19515932, "end_pos": 19496721, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056415.4", "url": "https://www.ensembl.org/id/ENSBTAT00000056415.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051727.3", "url": "https://www.ensembl.org/id/ENSBTAP00000051727.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8876198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "resource": "Reactome", "description": "RAB GEFs exchange GTP for GDP on RABs" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BFN6-1", "protein_name": "HPS1 biosis of lysosomal organelles complex 3 subunit 1", "gene_name": "HPS1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKCVLVATEGAEVLFYWTDEEFKESLRLKFGQSENEGEELPALEDQLSTLLAPVIISSMTMLEKLSDTYTCFSTENGSYLYVLQQFGECLFIAINGDHTEGEGDLRQKLCVLKYLFEVHFGLVTMDSQLIRKELRPPDLEQRVRVWEHFQSLLRTYGRLREQEQSFAVEAVERLIHPQLCELCIETLERHVVQAINSSPRRAGEEALHTFLLVHSKLLAFYSSHSASSLRPADLLALILLVQDLYPSDSTAEDSDIQPRPQMARRSESIPVQQAWSTCSADPTGRSSAGTETDNFSLPEEYFTPAPSPGERSSGETWGGVTTAGEAGMAEDTLQTLVPHSPGLSSPRRIFLDASVKENYCPMVPHTMYCLPLWPGITMVLLTKSPSTPLALVLYQLLDGFSLLEKKLKEGQEAGSALRSHPLMGDLRQRMDKFVKSRGGHELQGASLGMPLGPFPAVTSHLPALRLLQACGRVKRQLCAIYRLSFLTTAPGQGGPHLPEDLQDQVQTLMQEKLADWRDFLLVKSKRNVTMILTYLEDFPGLVHFIYVDRTTGQMVAPSLSTSERTSSELGRGPLATFVKTKVWSLIRLARRYLQKGYTTLLFREGDFYCSYFLWFENEMGHKLQIIEVPVLSDDSAPVGMLGGDYYRKLLRYYSKGHPAEAVRCHELLALHLSVIPTDVLVRQAAELARRLGEASRMPLP", "length": 700 }, "evidence": [ { "id": "E1B7M9", "url": "https://omabrowser.org/oma/group/E1B7M9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6AEI1-1", "protein_name": "HPS1, biogenesis of lysosomal organelles complex 3 subunit 1", "gene_name": "Hps1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRCVLVATEGAEVLFYWTDEEFEENLRQKFRQSENEEEELPVLEDQLNTLLAPVIISYMTMLEKLSDTYTCFSTENGDHLYVLHLFGECLFIAINGDHSENEGDLRRKLCVLKYLFEVHFGLVTVDSQLIRKELRPPDLEQRAQVWKHFQRLLGTYSRLREQEQSFAVEAVERLIHAQLCELSIETLERHVVQAVNSSPERGGEEVLHAFLLVHCKLLAFYSSHVASALRPADLLALILLVQDLQPSQGTTEEEEDGNDGPQPFPHRRPMSSQNIPVQQPRSQSTSVPTRSSKETDTDSISLPEEYFTPAPSPGEQSSGSLVWLDGGTPPSDVLQMAEDTFNGLAPHSPELPRPRRIFLDANIKENYCPLVPHTMYCLPLWPGISMVLLTKSPSTPLALILYQLLDGFSLLEKKLKEGQEAGSALRSQPFVGDLRQKMDKFIKNRVGQEIQNAWLEFKSKAFSRSEPGSSWELLQICGKLKRQLCAIYRLNFLATAPSRGGPHLPQHLQSQAQKLMKERLQDWKDFLLVKSWRNVTIVSYLEDFPGLVHFIYVDRTTGQMVAPSLSPSEKMSSELGKGPLAAFVKAKVWALIRLARRYLQKGCTTLLFQEGDFRCSYFLWFENDMGYKLQMIEVPVLSDDSVPIGVLGGDYYRKLLRYYSKSRPSEPVRCYELLTLHLSVIPTDLLVQQANQLARRLGEASRVTLP", "length": 706 }, "evidence": [ { "id": "E1B7M9", "url": "https://omabrowser.org/oma/group/E1B7M9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A9J7JH81-1", "protein_name": "Hermansky-Pudlak syndrome 1 protein isoform X1", "gene_name": "Hps1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKCVLVATEGAEVLFYWTDEEFEENLRLKFRQSENEEEELPALEDQLSTLLAPVIISSVTMLEKLSDTYTCFSTENGKHLYVLHLFGECLFIAINGDHSESEGDLRRKLCVLKYLFEVHFGLVTVDSQLIRKELRPPDLDQRARVWKHFQRLLGTYSHLREQEQSFAVEAVERLIHPQLCELSIETLERHVVQAVNSSPERGSEEALHAFLLVHCKLLAFYSSHGASTLRPADLLALILLVQDLHPTQDTTEEDDNDDSSPQSFPQRRPLSSQNIPVQQARSQSTSGPTRSSEETDTDSISLPEEYFTPAPSPGEQSSGSILWLDGGTPPTDIPQMAEGTLRGLMPHSPEPSSPQRIFLDANVKENYCPLVPHTMYCLPLWPGINMVLLTKSSSTALALVLYQLLDGFSLLEKKLKEGQEPGSALRSQPFVGDLRQKMDKFIKNRVGQEIQSSWLEFKTKAFSRSEAGSSWELLQACGKLKRQLCTIYRLSFLATAPSRGGPHLPQHLQDQAQKLMKERLLDWKDFLLVKSRRNVTMVSYLEDFPGLVHFIYVDRTTGQMVAPSLSNSEKMSSELGKGPLAAFVKAKVWALVRLARRYLQKGCTTLLFQEGDFRCSYFLWFENDMGYKLQMIEVPVLSEDSVPIGVLGGDYYRKLLRYYSKSRPSEPVRCYELLTLHLSVIPTDLLVQQASQLARRLGEASRVTLP", "length": 706 }, "evidence": [ { "id": "E1B7M9", "url": "https://omabrowser.org/oma/group/E1B7M9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O08983-1", "protein_name": "BLOC-3 complex member HPS1", "gene_name": "Hps1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKCVLVATEGAEVLFYWTDEEFAESLRLKLQQSEDEEEELPVLEDQLSTLLAPVIISSMTMLEKLSDTYTCFSTENDNHLYVLHLFGEYLFVAINGDHSESEGDLRRKLCVLKYLFEVHFGLVTVDGQLIRKELRPPDLEERARVWKHFQRLLGTYSYLRDREQSFAVEAVERLIHPQLCEQSIETLERHVVQAINASPERGGEEVLHAFLLVHCKLLAFYSGHGASTLRPADLLALILLVQDLQPSPGTTEEEEEEEDSDSPQRRPKSSQNIPVQQARSQSTSVPTRSSRETDTDSISLPEEYFTPAPSPGDQSSGSLVWLDGGTPPSDALQMAEDTPEGLASHSPELPSPRRIFLDANIKENYCPLVPHTMYCLPLWPGINMVLLTKSPSTPLALILYQLLDGFSLLEKKLKEGQEAGSALRSQPFVADLRQKMDKFIKNRVGQEIQNTWLEFKSKAFSRSEPGSSWELLQVCGKLKRQLCVIYRLSFLVTAPSRGGPHLPQHLQDRAQKLMKERLLDWKDFLLVKSRRNVTMVSYLEDFPGLVHFIYVDRTTGQMVAPSLSPNEKMSSELGKGPLAAFVKAKVWALVRLARRYLQKGCTTLLFQEGDFRCSYFLWFENDMGYKLQMIEVPVLSDDSVPIGVLGGDYYRKLLRYYSKSHPSEPVRCYELLTLHLSVIPTDLLVQQASQLARRLGEASRVTLP", "length": 704 }, "evidence": [ { "id": "E1B7M9", "url": "https://omabrowser.org/oma/group/E1B7M9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92902-1", "protein_name": "BLOC-3 complex member HPS1", "gene_name": "HPS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKCVLVATEGAEVLFYWTDQEFEESLRLKFGQSENEEEELPALEDQLSTLLAPVIISSMTMLEKLSDTYTCFSTENGNFLYVLHLFGECLFIAINGDHTESEGDLRRKLYVLKYLFEVHFGLVTVDGHLIRKELRPPDLAQRVQLWEHFQSLLWTYSRLREQEQCFAVEALERLIHPQLCELCIEALERHVIQAVNTSPERGGEEALHAFLLVHSKLLAFYSSHSASSLRPADLLALILLVQDLYPSESTAEDDIQPSPRRARSSQNIPVQQAWSPHSTGPTGGSSAETETDSFSLPEEYFTPAPSPGDQSSGSTIWLEGGTPPMDALQIAEDTLQTLVPHCPVPSGPRRIFLDANVKESYCPLVPHTMYCLPLWQGINLVLLTRSPSAPLALVLSQLMDGFSMLEKKLKEGPEPGASLRSQPLVGDLRQRMDKFVKNRGAQEIQSTWLEFKAKAFSKSEPGSSWELLQACGKLKRQLCAIYRLNFLTTAPSRGGPHLPQHLQDQVQRLMREKLTDWKDFLLVKSRRNITMVSYLEDFPGLVHFIYVDRTTGQMVAPSLNCSQKTSSELGKGPLAAFVKTKVWSLIQLARRYLQKGYTTLLFQEGDFYCSYFLWFENDMGYKLQMIEVPVLSDDSVPIGMLGGDYYRKLLRYYSKNRPTEAVRCYELLALHLSVIPTDLLVQQAGQLARRLWEASRIPLL", "length": 700 }, "evidence": [ { "id": "E1B7M9", "url": "https://omabrowser.org/oma/group/E1B7M9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "E1B7M9", "url": "https://www.uniprot.org/uniprotkb/E1B7M9" } ], "pmid": "" }, { "name": "melanosome assembly", "id": "GO:1903232", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903232", "evidence": [ { "database": "UniProtKB", "id": "E1B7M9", "url": "https://www.uniprot.org/uniprotkb/E1B7M9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "BLOC-3 complex", "id": "GO:0031085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031085", "evidence": [ { "database": "UniProtKB", "id": "E1B7M9", "url": "https://www.uniprot.org/uniprotkb/E1B7M9" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "E1B7M9", "url": "https://www.uniprot.org/uniprotkb/E1B7M9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "E1B7M9", "url": "https://www.uniprot.org/uniprotkb/E1B7M9" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "E1B7M9", "url": "https://www.uniprot.org/uniprotkb/E1B7M9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 530, "end_pos": 532, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7M9" }, { "id": "PF19038", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19038" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FUZ/MON1/HPS1 third Longin", "eco_id": "ECO_0000259", "start_pos": 542, "end_pos": 694, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 196, "end_pos": 198 }, { "start_pos": 225, "end_pos": 227 }, { "start_pos": 530, "end_pos": 532 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BAI7-1", "uniprot_ac": "E1BAI7", "uniprot_id": "E1BAI7_BOVIN", "mass": { "chemical_mass": 39528.0, "monoisotopic_mass": 39528.0 }, "refseq": { "ac": "NP_001179645", "name": "tropomodulin-2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179645" }, "gene_names": [ { "name": "TMOD2", "type": "recommended", "evidence": [ { "id": "E1BAI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAI7" } ] }, { "name": "TMOD2", "type": "synonym", "evidence": [ { "id": "NP_001179645", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179645" } ] } ], "protein_names": [ { "name": "Tropomodulin 2", "type": "synonym", "evidence": [ { "id": "E1BAI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAI7/entry#names_and_taxonomy" } ] }, { "name": "tropomodulin 2 (neuronal)", "type": "synonym", "evidence": [ { "id": "NP_001179645", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179645" } ] }, { "name": "tropomodulin-2", "type": "synonym", "evidence": [ { "id": "NP_001179645", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179645" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAI7", "url": "https://www.uniprot.org/uniprotkb/E1BAI7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMOD2", "url": "https://www.uniprot.org/uniprotkb/E1BAI7", "locus": { "chromosome": "10", "start_pos": 58560371, "end_pos": 58609729, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014011", "url": "https://www.ensembl.org/id/ENSBTAG00000014011" } ] } } ], "crossref": [ { "id": "E1BAI7", "url": "https://alphafold.ebi.ac.uk/entry/E1BAI7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014011", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014011", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532085", "url": "https://www.ncbi.nlm.nih.gov/gene/532085", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004934", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004934", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532085", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532085", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LEHQDRP", "url": "https://omabrowser.org/oma/group/LEHQDRP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAI7", "url": "https://www.orthodb.org/?gene=E1BAI7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BC32", "url": "https://www.orthodb.org/?gene=E1BC32", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10901", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10901", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10901:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10901:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03250", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03250", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27087", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27087", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-390522", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390522", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179645", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6S8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6S8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6S8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXX1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXX1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAI7", "url": "https://www.uniprot.org/uniprotkb/E1BAI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAI7-1", "url": "https://www.uniprot.org/uniprotkb/E1BAI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC32", "url": "https://www.uniprot.org/uniprotkb/E1BC32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC32-1", "url": "https://www.uniprot.org/uniprotkb/E1BC32-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALPFQKELEKYKNIDEDELLGKLSEEELKQLENVLDDLDPESALLPAGFRQKDQTQKAATGPFDREHLLMYLEKEALEQKDREDFVPFTGEKKGRVFIPKEKPIETHKEEKVTLDPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETTNTKGGKGPVRNVVKGEKVKPVFEEPPNPTNVEVSLQQMKANDPSLQEVNLNNIKNIPIPTLKEFAKALETNTHVKKFSLAATRSNDPVAIAFADMLKVNKTLKSLNIESNFITGAGILALVEALKENDTLIEIKIDNQRQQLGTAVEMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAITKNNDLVRKKRVEGDRR", "length": 351, "header": "tr|E1BAI7-1|E1BAI7_BOVIN Isoform 1 of Tropomodulin 2 OS=Bos taurus OX=9913 GN=TMOD2 PE=3 SV=2 CANONICAL=E1BAI7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6S8-1", "url": "https://www.uniprot.org/uniprotkb/E1BAI7/entry#A0AAA9S6S8-1", "sequence": { "sequence": "MALPFQKELEKYKNIDEDELLGKLSEEELKQLENVLDDLDPESALLPAGFRQKDQTQKAATGPFDREHLLMYLEKEALEQKDREDFVPFTGEKKGRVFIPKEKPIETHKEEKVTLDPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETTNTKGGKGPVRNVVKGEKVKPVFEEPPNPTNVEVSLQQMKANDPSLQEVNLNNIKNIPIPTLKEFAKALETNTHVKKFSLAATRSNDPVAIAFADMLKVNKTLKSLNIESNFITGAGILALVEALKENDTLIEIKIDNQRQQLGTAVEMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAITKNNDLVRKKRVEGDRSATYLSWIF", "length": 359, "header": "tr|A0AAA9S6S8-1|E1BAI7_BOVIN Computationally mapped isoform of Tropomodulin 2 OS=Bos taurus OX=9913 GN=TMOD2 PE=3 SV=1 CANONICAL=E1BAI7-1" }, "locus": { "chromosome": "10", "start_pos": 58593201, "end_pos": 58561839, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121985.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121985.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077866.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077866.1" } ] } }, { "isoform_ac": "A0AAA9SXX1-1", "url": "https://www.uniprot.org/uniprotkb/E1BAI7/entry#A0AAA9SXX1-1", "sequence": { "sequence": "MALPFQKELEKYKNIDEDELLGKLSEEELKQLENVLDDLDPESALLPAGFRQKDQTQKAATGPFDREHLLMYLEKEALEQKDREDFVPFTGEKKGRVFIPKEKPIETHKEEKVTLDPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETTNTKGGKGPVRNVVKGEKVKPVFEEPPNPTNVEVSLQQMKANDPSLQEVNLNNIKNIPIPTLKEFAKALETNTHVKKFSLAATRSNDPVAIAFADMLKVNKTLKSLNIESNFITGAGILALVEALKENDTLIEIKIDNQPQPTESLELLYRLQLAPVCKQQLSVLSMMSCPVPLAAEMCLPWDSGNLKGLDTM", "length": 346, "header": "tr|A0AAA9SXX1-1|E1BAI7_BOVIN Computationally mapped isoform of Tropomodulin 2 OS=Bos taurus OX=9913 GN=TMOD2 PE=3 SV=1 CANONICAL=E1BAI7-1" }, "locus": { "chromosome": "10", "start_pos": 58593201, "end_pos": 58570014, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113292.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113292.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088159.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088159.1" } ] } }, { "isoform_ac": "A0AAA9TDG7-1", "url": "https://www.uniprot.org/uniprotkb/E1BAI7/entry#A0AAA9TDG7-1", "sequence": { "sequence": "MALPFQKELEKYKNIDEDELLGKLSEEELKQLENVLDDLDPESALLPAGFRQKDQTQKAATGPFDREHLLMYLEKEALEQKDREDFVPFTGEKKGRVFIPKEKPIETHKEEKVTLDPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETTNTKGGKGPVRNVVKGEKVKPVFEEPPNPTNVEVSLQQMKANDPSLQEVNLNNIKAFADMLKVNKTLKSLNIESNFITGAGILALVEALKENDTLIEIKIDNQRQQLGTAVEMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAITKNNDLVRKKRVEGDRR", "length": 315, "header": "tr|A0AAA9TDG7-1|E1BAI7_BOVIN Computationally mapped isoform of Tropomodulin 2 OS=Bos taurus OX=9913 GN=TMOD2 PE=3 SV=1 CANONICAL=E1BAI7-1" }, "locus": { "chromosome": "10", "start_pos": 58593201, "end_pos": 58562011, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099559.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099559.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096677.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096677.1" } ] } }, { "isoform_ac": "E1BAI7-1", "url": "https://www.uniprot.org/uniprotkb/E1BAI7/entry#E1BAI7-1", "sequence": { "sequence": "MALPFQKELEKYKNIDEDELLGKLSEEELKQLENVLDDLDPESALLPAGFRQKDQTQKAATGPFDREHLLMYLEKEALEQKDREDFVPFTGEKKGRVFIPKEKPIETHKEEKVTLDPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETTNTKGGKGPVRNVVKGEKVKPVFEEPPNPTNVEVSLQQMKANDPSLQEVNLNNIKNIPIPTLKEFAKALETNTHVKKFSLAATRSNDPVAIAFADMLKVNKTLKSLNIESNFITGAGILALVEALKENDTLIEIKIDNQRQQLGTAVEMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAITKNNDLVRKKRVEGDRR", "length": 351, "header": "tr|E1BAI7-1|E1BAI7_BOVIN Isoform 1 of Tropomodulin 2 OS=Bos taurus OX=9913 GN=TMOD2 PE=3 SV=2 CANONICAL=E1BAI7-1" }, "locus": { "chromosome": "10", "start_pos": 58593201, "end_pos": 58562011, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018618.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018618.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018618.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018618.5" } ] } }, { "isoform_ac": "E1BC32-1", "url": "https://www.uniprot.org/uniprotkb/E1BAI7/entry#E1BC32-1", "sequence": { "sequence": "MALPFQKELEKYKNIDEDELLGKLSEEELKQLENVLDDLDPESALLPAGFRQKDQTQKAATGPFDREHLLMYLEKEALEQKDREDFVPFTGEKKGRVFIPKEKPIETHKEEKVTLDPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETTNTKGGKGPVRNVVKGEKVKPVFEEPPNPTNVEVSLQQMKANDPSLQEVNLNNIKNIPIPTLKEFAKALETNTHVKKFSLAATRSNDPVAIAFADMLKVNKTLKSLNIESNFITGAGILALVEALKENDTLIEIKIDNQPQPTESLELLYRLQLAPVCKQQLSVLSMMSCPVPLAAEMCLPWDSGNLKETAVGNSRGDGNCPDAGGEFQDPQVWISVYQARTTNKSGSCHHKEQ", "length": 387, "header": "tr|E1BC32-1|E1BAI7_BOVIN Computationally mapped isoform of Tropomodulin 2 OS=Bos taurus OX=9913 GN=TMOD2 PE=3 SV=4 CANONICAL=E1BAI7-1" }, "locus": { "chromosome": "10", "start_pos": 58593201, "end_pos": 58564313, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026116.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026116.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026116.7", "url": "https://www.ensembl.org/id/ENSBTAP00000026116.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:532085", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532085", "resource": "KEGG Pathway" }, { "id": "R-BTA-390522", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390522", "resource": "Reactome", "description": "Striated Muscle Contraction" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PW62-1", "protein_name": "Tropomodulin 2", "gene_name": "TMOD2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSLPFRKELEKYKNINEDEILSKLSEDELKQLEHVLDDLDPENALLPAGFRQKDQTTKPATGPFDRERLLSYLEKQALEHKDREDFVPFTGEKKGKIFIPKEKPIETRTEEKVTLDPELEEALASASDTELYDLAAVLGVHNMVNNPKFDEGGARSKDGKGSMRNVVKGEKVKPIFEEPPNPTNVEASLQRIKANDPTLVEVNLNNIKNIPIPTLKEFAKALESNVHVKTFSLAATRSNDPVAIAFADMLKVNKTLKSLNVESNFITGTGILALIDALKENESLTEIKIDNQRQQLGTAVEMEIAKMLEENSKILKFGYQFTKQGPRTRVAAAITKNNDLVRKKRVEGERQ", "length": 351 }, "evidence": [ { "id": "E1BAI7", "url": "https://omabrowser.org/oma/group/E1BAI7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A287BG70-1", "protein_name": "Tropomodulin 2", "gene_name": "TMOD2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALPFQKELEKYKNIDEDELLGKLSEEELKQLENVLDDLDPESALLPAGFRQKDQTQKAATGPFDREHLLMYLEKEALEQKDREDFVPFTGEKKGRVFIPKEKPVETRKEEKVTLDPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETTGTKGGKGPVRNVVKGEKVKPVFEEPPNPTNVEVSLQQMKANDPSLQEVNLNNIKNIPIPTLKEFAKALETNTHVKKFSLAATRSNDPVAIAFADMLKVNKTLKSLNIESNFITGAGILALVEALKENDTLTEIKIDNQRQQLGTAVEMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAITKNNDLVRKKRVEGDRR", "length": 351 }, "evidence": [ { "id": "E1BAI7", "url": "https://omabrowser.org/oma/group/E1BAI7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2QGS6-1", "protein_name": "Tropomodulin-2", "gene_name": "Tmod2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MALPFQKELEKYKNIDEDELLGKLSEEELKQLENVLDDLDPESAMLPAGFRQKDQTQKAATGPFDREHLLMYLEKEALEQKDREDFVPFTGEKKGRVFIPKEKPVEAPKEEKVTLDPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETTNGKGHKGPVRNVVKGEKAKPVFEEPPNPTNVEASLQQMKANDPSLQEVNLNNIKNIPIPTLKEFAKALETNTHVKKFSLAATRSNDPVALAFADMLKVNKTLKSLNIESNFITGAGILALVEALKENDTLTEIKIDNQRQQLGTAVEMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAITKNNDLVRKKRLEGDRR", "length": 351 }, "evidence": [ { "id": "E1BAI7", "url": "https://omabrowser.org/oma/group/E1BAI7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P70566-1", "protein_name": "Tropomodulin-2", "gene_name": "Tmod2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALPFQKGLEKYKNIDEDELLGKLSEEELKQLENVLDDLDPESATLPAGFRQKDQTQKAATGPFDREHLLMYLEKEALEQKDREDFVPFTGEKKGRVFIPKEKPVETRKEEKVTLDPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETTNGQGRKGPVRNVVKGEKAKPVFEEPPNPTNVEASLQQMKANDPSLQEVNLNNIKNIPIPTLKEFAKALETNTHVRKFSLAATRSNDPVALAFAEMLKVNKTLKSLNVESNFITGAGILALVEALRENDTLTEIKIDNQRQQLGTAVEMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAITKNNDLVRKKRVEGDRR", "length": 351 }, "evidence": [ { "id": "E1BAI7", "url": "https://omabrowser.org/oma/group/E1BAI7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9JKK7-1", "protein_name": "Tropomodulin-2", "gene_name": "Tmod2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALPFQKGLEKYKNIDEDELLGKLSEEELKQLENVLDDLDPESATLPAGFRQKDQTQKAATGPFDREHLLMYLEKEALEQKDREDFVPFTGEKKGRVFIPKEKPVETRKEEKVTLDPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETTNGEGRKGPVRNVVKGEKAKPVFEEPPNPTNVEASLQQMKANDPSLQEVNLNNIKNIPIPTLKEFAKSLETNTHVKKFSLAATRSNDPVALAFAEMLKVNKTLKSLNVESNFITGTGILALVEALRENDTLTEIKIDNQRQQLGTAVEMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAITKNNDLVRKKRVEGDRR", "length": 351 }, "evidence": [ { "id": "E1BAI7", "url": "https://omabrowser.org/oma/group/E1BAI7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NZR1-1", "protein_name": "Tropomodulin-2", "gene_name": "TMOD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALPFQKELEKYKNIDEDELLGKLSEEELKQLENVLDDLDPESAMLPAGFRQKDQTQKAATGPFDREHLLMYLEKEALEQKDREDFVPFTGEKKGRVFIPKEKPIETRKEEKVTLDPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETANNKGGKGPVRNVVKGEKVKPVFEEPPNPTNVEISLQQMKANDPSLQEVNLNNIKNIPIPTLREFAKALETNTHVKKFSLAATRSNDPVAIAFADMLKVNKTLTSLNIESNFITGTGILALVEALKENDTLTEIKIDNQRQQLGTAVEMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAITKNNDLVRKKRVEADRR", "length": 351 }, "evidence": [ { "id": "E1BAI7", "url": "https://omabrowser.org/oma/group/E1BAI7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "E1BAI7", "url": "https://www.uniprot.org/uniprotkb/E1BAI7" } ], "pmid": "" }, { "name": "tropomyosin binding", "id": "GO:0005523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005523", "evidence": [ { "database": "UniProtKB", "id": "E1BAI7", "url": "https://www.uniprot.org/uniprotkb/E1BAI7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "E1BAI7", "url": "https://www.uniprot.org/uniprotkb/E1BAI7" } ], "pmid": "" }, { "name": "striated muscle thin filament", "id": "GO:0005865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005865", "evidence": [ { "database": "UniProtKB", "id": "E1BAI7", "url": "https://www.uniprot.org/uniprotkb/E1BAI7" } ], "pmid": "" }, { "name": "myofibril", "id": "GO:0030016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030016", "evidence": [ { "database": "UniProtKB", "id": "E1BAI7", "url": "https://www.uniprot.org/uniprotkb/E1BAI7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "pointed-end actin filament capping", "id": "GO:0051694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051694", "evidence": [ { "database": "UniProtKB", "id": "E1BAI7", "url": "https://www.uniprot.org/uniprotkb/E1BAI7" } ], "pmid": "" }, { "name": "muscle contraction", "id": "GO:0006936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006936", "evidence": [ { "database": "UniProtKB", "id": "E1BAI7", "url": "https://www.uniprot.org/uniprotkb/E1BAI7" } ], "pmid": "" }, { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "E1BAI7", "url": "https://www.uniprot.org/uniprotkb/E1BAI7" } ], "pmid": "" }, { "name": "myofibril assembly", "id": "GO:0030239", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030239", "evidence": [ { "database": "UniProtKB", "id": "E1BAI7", "url": "https://www.uniprot.org/uniprotkb/E1BAI7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 281, "end_pos": 283, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAI7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 351, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAI7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAI7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 253, "end_pos": 255 }, { "start_pos": 281, "end_pos": 283 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BAQ2-1", "uniprot_ac": "E1BAQ2", "uniprot_id": "E1BAQ2_BOVIN", "mass": { "chemical_mass": 59898.0, "monoisotopic_mass": 59898.0 }, "refseq": { "ac": "XP_005214871", "name": "YTH domain-containing family protein 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214871" }, "gene_names": [ { "name": "YTHDF1", "type": "recommended", "evidence": [ { "id": "E1BAQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2" } ] }, { "name": "YTHDF1", "type": "synonym", "evidence": [ { "id": "XP_005214871", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214871" } ] } ], "protein_names": [ { "name": "YTH domain-containing family protein", "type": "recommended", "evidence": [ { "id": "E1BAQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2/entry#names_and_taxonomy" } ] }, { "name": "YTH domain-containing family protein 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005214871", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214871" } ] } ], "function": [ { "annotation": "Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ2", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2#function" }, { "database": "UniProtKB", "id": "RU369095", "url": "https://www.uniprot.org/uniprotkb/RU369095#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAQ2", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "YTHDF1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2", "locus": { "chromosome": "13", "start_pos": 54345591, "end_pos": 54332616, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010383", "url": "https://www.ensembl.org/id/ENSBTAG00000010383" } ] } } ], "crossref": [ { "id": "E1BAQ2", "url": "https://alphafold.ebi.ac.uk/entry/E1BAQ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010383", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010383", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21134", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21134", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538525", "url": "https://www.ncbi.nlm.nih.gov/gene/538525", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007275", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007275", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045168", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045168", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BAQ2", "url": "https://www.orthodb.org/?gene=E1BAQ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12357", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12357", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12357:SF65", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12357:SF65", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04146", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04146", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005214871", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214871", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S764", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S764", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S764-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S764-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAQ2", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAQ2-1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKHVGHQRGPPVQNGSLHQKDTVHDNDFEPYLSGQSNQSNSYPSMADPYLSSYYPPSIGFPYSLNEAPWSTGGDPPIPYLTTYGQLSNGDHHFVHDAVFGQPGGLGSNIYQHRFNFFPENPAFSAWGTSGSQGQQAQSSAYGNSYTYPPSSLGGTIVDGQTGFHGDTLNKAPGMNSLEQGMVGLKIGDVTTSAVKTVGSVVSSVAMTGILSGNGGTNVPLPVSKPTSWAAIASKPAKPQPKMKAKSGPAIGGALPPPPIKHNMDIGTWDNKGPVPKAPAPQQVPASSAAPQPQPAMQPLPAQPPLPAPPQHTGPQQLPQTRWVAPRSRNAAFGQTGGLGSDSNSSGGAQPSTTPSAESHPVLEKLKAAHSYNPKEFDWNLKSGRVFIIKSYSEDDVHRSIKYSLWCSTEHGNRRLDSAFRALGSKGPVYLLFSVNGSGHFCGVAEMKSPVDYGTSAGVWSQDKWKGKFDVKWIFVKDVPNSQLRHIRLENNDNKPVTNSRDTQEVPLEKARQVLRIIASYRHSTSIFDDFSHYERRQEEEEVVRKERQSRNKQ", "length": 553, "header": "tr|E1BAQ2-1|E1BAQ2_BOVIN Isoform 1 of YTH domain-containing family protein OS=Bos taurus OX=9913 GN=YTHDF1 PE=3 SV=4 CANONICAL=E1BAQ2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S764-1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2/entry#A0AAA9S764-1", "sequence": { "sequence": "MSATSVDPQRTKGQDNKVQNGSLHQKDTVHDNDFEPYLSGQSNQERQSRNKQ", "length": 52, "header": "tr|A0AAA9S764-1|E1BAQ2_BOVIN Computationally mapped isoform of YTH domain-containing family protein OS=Bos taurus OX=9913 GN=YTHDF1 PE=3 SV=1 CANONICAL=E1BAQ2-1" }, "locus": { "chromosome": "13", "start_pos": 54344254, "end_pos": 54332822, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091862.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091862.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079749.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079749.1" } ] } }, { "isoform_ac": "E1BAQ2-1", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2/entry#E1BAQ2-1", "sequence": { "sequence": "MKHVGHQRGPPVQNGSLHQKDTVHDNDFEPYLSGQSNQSNSYPSMADPYLSSYYPPSIGFPYSLNEAPWSTGGDPPIPYLTTYGQLSNGDHHFVHDAVFGQPGGLGSNIYQHRFNFFPENPAFSAWGTSGSQGQQAQSSAYGNSYTYPPSSLGGTIVDGQTGFHGDTLNKAPGMNSLEQGMVGLKIGDVTTSAVKTVGSVVSSVAMTGILSGNGGTNVPLPVSKPTSWAAIASKPAKPQPKMKAKSGPAIGGALPPPPIKHNMDIGTWDNKGPVPKAPAPQQVPASSAAPQPQPAMQPLPAQPPLPAPPQHTGPQQLPQTRWVAPRSRNAAFGQTGGLGSDSNSSGGAQPSTTPSAESHPVLEKLKAAHSYNPKEFDWNLKSGRVFIIKSYSEDDVHRSIKYSLWCSTEHGNRRLDSAFRALGSKGPVYLLFSVNGSGHFCGVAEMKSPVDYGTSAGVWSQDKWKGKFDVKWIFVKDVPNSQLRHIRLENNDNKPVTNSRDTQEVPLEKARQVLRIIASYRHSTSIFDDFSHYERRQEEEEVVRKERQSRNKQ", "length": 553, "header": "tr|E1BAQ2-1|E1BAQ2_BOVIN Isoform 1 of YTH domain-containing family protein OS=Bos taurus OX=9913 GN=YTHDF1 PE=3 SV=4 CANONICAL=E1BAQ2-1" }, "locus": { "chromosome": "13", "start_pos": 54344254, "end_pos": 54332815, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013703.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013703.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013703.7", "url": "https://www.ensembl.org/id/ENSBTAP00000013703.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "regulation of axon guidance", "id": "GO:1902667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902667", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ2", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2" } ], "pmid": "" }, { "name": "learning", "id": "GO:0007612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007612", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ2", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2" } ], "pmid": "" }, { "name": "memory", "id": "GO:0007613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007613", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ2", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2" } ], "pmid": "" }, { "name": "regulation of long-term synaptic potentiation", "id": "GO:1900271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900271", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ2", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2" } ], "pmid": "" }, { "name": "stress granule assembly", "id": "GO:0034063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034063", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ2", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2" } ], "pmid": "" }, { "name": "mRNA destabilization", "id": "GO:0061157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061157", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ2", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2" } ], "pmid": "" }, { "name": "positive regulation of translational initiation", "id": "GO:0045948", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045948", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ2", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2" } ], "pmid": "" }, { "name": "regulation of antigen processing and presentation", "id": "GO:0002577", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002577", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ2", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ2", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2" } ], "pmid": "" }, { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ2", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2" } ], "pmid": "" }, { "name": "N6-methyladenosine-containing RNA reader activity", "id": "GO:1990247", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990247", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ2", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ2", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2" } ], "pmid": "" }, { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ2", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2" } ], "pmid": "" }, { "name": "cytoplasmic stress granule", "id": "GO:0010494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010494", "evidence": [ { "database": "UniProtKB", "id": "E1BAQ2", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 14, "end_pos": 16, "annotation": "n_glycosylation_sequon" }, { "start_pos": 343, "end_pos": 345, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" }, { "start_pos": 435, "end_pos": 437, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAQ2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 553, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAQ2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAQ2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAQ2" }, { "id": "PS50882", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50882" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "YTH", "eco_id": "ECO_0000259", "start_pos": 383, "end_pos": 517, "start_aa": "Gly", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 14, "end_pos": 16 }, { "start_pos": 343, "end_pos": 345 }, { "start_pos": 37, "end_pos": 39 }, { "start_pos": 435, "end_pos": 437 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BD69-1", "uniprot_ac": "E1BD69", "uniprot_id": "E1BD69_BOVIN", "mass": { "chemical_mass": 46307.0, "monoisotopic_mass": 46307.0 }, "refseq": { "ac": "XP_002685733", "name": "XK-related protein 8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685733" }, "gene_names": [ { "name": "XKR8", "type": "recommended", "evidence": [ { "id": "E1BD69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD69" } ] }, { "name": "XKR8", "type": "synonym", "evidence": [ { "id": "XP_002685733", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685733" } ] } ], "protein_names": [ { "name": "XK-related protein", "type": "recommended", "evidence": [ { "id": "E1BD69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD69/entry#names_and_taxonomy" } ] }, { "name": "XK-related protein 8", "type": "synonym", "evidence": [ { "id": "XP_002685733", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685733" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BD69", "url": "https://www.uniprot.org/uniprotkb/E1BD69" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "XKR8", "url": "https://www.uniprot.org/uniprotkb/E1BD69", "locus": { "chromosome": "2", "start_pos": 125393008, "end_pos": 125400457, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008800", "url": "https://www.ensembl.org/id/ENSBTAG00000008800" } ] } } ], "crossref": [ { "id": "E1BD69", "url": "https://alphafold.ebi.ac.uk/entry/E1BD69", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008800", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008800", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514365", "url": "https://www.ncbi.nlm.nih.gov/gene/514365", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018629", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018629", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050895", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050895", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514365", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514365", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PKLWRPP", "url": "https://omabrowser.org/oma/group/PKLWRPP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BD69", "url": "https://www.orthodb.org/?gene=E1BD69", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16024", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16024", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16024:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16024:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09815", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09815", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002685733", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685733", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "38663", "url": "https://www.rhea-db.org/rhea/38663", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S8B4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8B4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8B4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8B4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD69", "url": "https://www.uniprot.org/uniprotkb/E1BD69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD69-1", "url": "https://www.uniprot.org/uniprotkb/E1BD69-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPWSPRAVLLRDLVLGILGTLAFLIDLGADLWAASQYVLSGRYLWAALVLALLGLASVALQLFSWIWLHSDVSSPLAPKPPGRHLALLHLLQLGYLYRCVQGLQQGLLVWRQEAPSEFDLAYADFLSLDISMLRLFETFLETTPQLTLVLAIILQSGSAEYYQWVSICTSFVGISWALLDYHRALRTCLPAKLLLGPGASVIYFLWNLLLLWPRVLVVALFSALFPRYVALHFLGLWLVFLFWVWLQGTDFMPGPHSEWLYRATVATILYFSWFNVAEGHTRGRATIHLVFLLNDSLLLVVAWATQSAWLPSGRLLQSLLPAAGVCFLLGLALRLAYYCWLHPSRRWEPDQVDGTWGLHSLEERQLLQNRRMAHLAKNFFPKARDEAVLPWKGEMNGILKAGSDPARET", "length": 409, "header": "tr|E1BD69-1|E1BD69_BOVIN Isoform 1 of XK-related protein OS=Bos taurus OX=9913 GN=XKR8 PE=3 SV=1 CANONICAL=E1BD69-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8B4-1", "url": "https://www.uniprot.org/uniprotkb/E1BD69/entry#A0AAA9S8B4-1", "sequence": { "sequence": "MLTGALGASRVLPRCVQGLQQGLLVWRQEAPSEFDLAYADFLSLDISMLRLFETFLETTPQLTLVLAIILQSGSAEYYQWVSICTSFVGISWALLDYHRALRTCLPAKLLLGPGASVIYFLWNLLLLWPRVLVVALFSALFPRYVALHFLGLWLVFLFWVWLQGTDFMPGPHSEWLYRATVATILYFSWFNVAEGHTRGRATIHLVFLLNDSLLLVVAWATQSAWLPSGRLLQSLLPAAGVCFLLGLALRLAYYCWLHPSRRWEPDQVDGTWGLHSLEERQLLQNRRMAHLAKNFFPKARDEAVLPWKGEMNGILKAGSDPARET", "length": 325, "header": "tr|A0AAA9S8B4-1|E1BD69_BOVIN Computationally mapped isoform of XK-related protein OS=Bos taurus OX=9913 GN=XKR8 PE=3 SV=1 CANONICAL=E1BD69-1" }, "locus": { "chromosome": "2", "start_pos": 125397470, "end_pos": 125394012, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128318.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128318.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079582.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079582.1" } ] } }, { "isoform_ac": "E1BD69-1", "url": "https://www.uniprot.org/uniprotkb/E1BD69/entry#E1BD69-1", "sequence": { "sequence": "MPWSPRAVLLRDLVLGILGTLAFLIDLGADLWAASQYVLSGRYLWAALVLALLGLASVALQLFSWIWLHSDVSSPLAPKPPGRHLALLHLLQLGYLYRCVQGLQQGLLVWRQEAPSEFDLAYADFLSLDISMLRLFETFLETTPQLTLVLAIILQSGSAEYYQWVSICTSFVGISWALLDYHRALRTCLPAKLLLGPGASVIYFLWNLLLLWPRVLVVALFSALFPRYVALHFLGLWLVFLFWVWLQGTDFMPGPHSEWLYRATVATILYFSWFNVAEGHTRGRATIHLVFLLNDSLLLVVAWATQSAWLPSGRLLQSLLPAAGVCFLLGLALRLAYYCWLHPSRRWEPDQVDGTWGLHSLEERQLLQNRRMAHLAKNFFPKARDEAVLPWKGEMNGILKAGSDPARET", "length": 409, "header": "tr|E1BD69-1|E1BD69_BOVIN Isoform 1 of XK-related protein OS=Bos taurus OX=9913 GN=XKR8 PE=3 SV=1 CANONICAL=E1BD69-1" }, "locus": { "chromosome": "2", "start_pos": 125400258, "end_pos": 125394012, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011592.6", "url": "https://www.ensembl.org/id/ENSBTAT00000011592.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011592.4", "url": "https://www.ensembl.org/id/ENSBTAP00000011592.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514365", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514365", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1STN1-1", "protein_name": "XK-related protein", "gene_name": "XKR8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPWSLHAVLFRDLVLGVLGTLAFLIDLGADLWAASQYVLSGRYLWAALVLALLGLASVALQFFSWVWLRTDPTGLHASQPPGQRLALLHLLQLGYLYRCVQGLQQGLLVWRQEVPSQFDLDYADFLSLDISMLRLFETFLETTPQLTLVLAIVLQSGSTEYYQWVSICTSFVGISWALLDYHRALRTCLPFKPLLGLGASAIYFLWNLLLLWPRVLVVALFSALFPRYVALHFLGLWLVLLLWVWLQGTDFMPDPCSEWLYRATVATILYFSWFNVAEGHTRGRAAIHLGFLLSDSLLIVVTWATHGAWLPSGLLLQVLLPVAGVCSLLGLALRLVYYRWLHPSCHWEPDRVDGTRGLYSLEGRRLPQNRRMVQLAKNFFPRDRDKSALPWKGEVNGVL", "length": 399 }, "evidence": [ { "id": "E1BD69", "url": "https://omabrowser.org/oma/group/E1BD69/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9H6D3-1", "protein_name": "XK-related protein 8", "gene_name": "XKR8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPWSSRGALLRDLVLGVLGTAAFLLDLGTDLWAAVQYALGGRYLWAALVLALLGLASVALQLFSWLWLRADPAGLHGSQPPRRCLALLHLLQLGYLYRCVQELRQGLLVWQQEEPSEFDLAYADFLALDISMLRLFETFLETAPQLTLVLAIMLQSGRAEYYQWVGICTSFLGISWALLDYHRALRTCLPSKPLLGLGSSVIYFLWNLLLLWPRVLAVALFSALFPSYVALHFLGLWLVLLLWVWLQGTDFMPDPSSEWLYRVTVATILYFSWFNVAEGRTRGRAIIHFAFLLSDSILLVATWVTHSSWLPSGIPLQLWLPVGCGCFFLGLALRLVYYHWLHPSCCWKPDPDQVDGARSLLSPEGYQLPQNRRMTHLAQKFFPKAKDEAASPVKG", "length": 395 }, "evidence": [ { "id": "E1BD69", "url": "https://omabrowser.org/oma/group/E1BD69/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BD69", "url": "https://www.uniprot.org/uniprotkb/E1BD69" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "E1BD69", "url": "https://www.uniprot.org/uniprotkb/E1BD69" } ], "pmid": "" }, { "name": "engulfment of apoptotic cell", "id": "GO:0043652", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043652", "evidence": [ { "database": "UniProtKB", "id": "E1BD69", "url": "https://www.uniprot.org/uniprotkb/E1BD69" } ], "pmid": "" }, { "name": "neutrophil clearance", "id": "GO:0097350", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097350", "evidence": [ { "database": "UniProtKB", "id": "E1BD69", "url": "https://www.uniprot.org/uniprotkb/E1BD69" } ], "pmid": "" }, { "name": "synapse pruning", "id": "GO:0098883", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098883", "evidence": [ { "database": "UniProtKB", "id": "E1BD69", "url": "https://www.uniprot.org/uniprotkb/E1BD69" } ], "pmid": "" }, { "name": "positive regulation of myoblast differentiation", "id": "GO:0045663", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045663", "evidence": [ { "database": "UniProtKB", "id": "E1BD69", "url": "https://www.uniprot.org/uniprotkb/E1BD69" } ], "pmid": "" }, { "name": "phosphatidylserine exposure on apoptotic cell surface", "id": "GO:0070782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070782", "evidence": [ { "database": "UniProtKB", "id": "E1BD69", "url": "https://www.uniprot.org/uniprotkb/E1BD69" } ], "pmid": "" }, { "name": "apoptotic process involved in development", "id": "GO:1902742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902742", "evidence": [ { "database": "UniProtKB", "id": "E1BD69", "url": "https://www.uniprot.org/uniprotkb/E1BD69" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phospholipid scramblase activity", "id": "GO:0017128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017128", "evidence": [ { "database": "UniProtKB", "id": "E1BD69", "url": "https://www.uniprot.org/uniprotkb/E1BD69" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 294, "end_pos": 296, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "38663", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MUP9-1" ], "evidence": [ { "id": "38663", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38663" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MUP9", "gene_name": "VAT1", "activity": [ { "ec_number": "1.6.5.5", "activity": "2 1,2-naphthoquinone + NADPH + H(+) = 2 1,2-naphthosemiquinone + NADP(+).", "evidence": [ { "id": "F1MUP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUP9" } ] }, { "ec_number": "1.6.5.5", "activity": "", "evidence": [ { "id": "F1MUP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUP9" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BD69-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 409, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BD69-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BD69" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 294, "end_pos": 296 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B8Q4-1", "uniprot_ac": "E1B8Q4", "uniprot_id": "E1B8Q4_BOVIN", "mass": { "chemical_mass": 112648.0, "monoisotopic_mass": 112648.0 }, "refseq": {}, "gene_names": [ { "name": "CHTF18", "type": "recommended", "evidence": [ { "id": "E1B8Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4" } ] } ], "protein_names": [ { "name": "Chromosome transmission fidelity protein 18 homolog", "type": "recommended", "evidence": [ { "id": "E1B8Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage.", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q4", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4#function" }, { "database": "UniProtKB", "id": "ARBA00059685", "url": "https://www.uniprot.org/uniprotkb/ARBA00059685#function" }, { "database": "UniProtKB", "id": "A0AAA9S906", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S906#function" }, { "database": "UniProtKB", "id": "A0AAA9SXJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXJ8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8Q4", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHTF18", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4", "locus": { "chromosome": "25", "start_pos": 684174, "end_pos": 669617, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019743", "url": "https://www.ensembl.org/id/ENSBTAG00000019743" } ] } } ], "crossref": [ { "id": "E1B8Q4", "url": "https://alphafold.ebi.ac.uk/entry/E1B8Q4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019743", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019743", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00009", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00009", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18140", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18140", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003959", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003959", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047854", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047854", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053016", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053016", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B8Q4", "url": "https://www.orthodb.org/?gene=E1B8Q4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46765", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46765", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46765:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46765:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00004", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00004", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-174411", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174411", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S906", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S906", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S906-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S906-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8Q4", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8Q4-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDYELELYGVEDDFDSQFAAELEVLAELEGSAALSPSRDPRPTVGRPRQTFEEAIVGGDAAIHCSPGGPPRNSKGSVRKRHLAPDIQGDRSLPPAPHIKRSRLQAVRRLNFRSEEMEEMTPPDSPTLDITPPPSPEIPDELLGEGPLDSGADAGLTQASLATRNPVLRRPPVLEDYVNVTSTGGDRAFLVLRADPVGTGVQSPFHDTGWRGRGQLDLLGMPFTSLKEKVDSERRRRLLEEAQRLSDMLCSLRSQEVEEETQPSGAPEEEPADSQDASQHCLWVDEFAPQRYTELLSDDFTNRCLLKWLKLWDLVVFGREKPVQKPRPSAEPARGGKEATASSKWKSHEQVLEEMLEAELDPSGRPRQKVALLCGPPGLGKTTLAHVIARHAGYCVVEMNASDDRSPEAFRTRIEAATQMESVLGAGGRPNCLVIDEIDGAPTAAINVLLSVLDRKGPQQAGPGGPSVPTGGGRRRRAEAGLLMRPIICICNDPFAPSLRQLKQQALLLHFPPTLPSRLMQRLQEISLRRGMRADPGALAALCEKTDNDIRACINALQFLHRRGQRELSVQAVQSTRIGLKDQRKGLFSVWQEVFQLPRAQRRRVRQDSTLRTHMLLLGDQLSGSGPLAAEAPLTTAAQRFYHILHVAMSAGEHEKVVQGLFDNFLRMRLRDSSLGAVCTALDWLAFDDLLGRAALHSQSFQLMCYLPFLLPAFHLLFASSHVPRITFPSSQQEAQNRMNQTQNLIQTLVSGITPATRSWAAPQALILDTLCLLLDILTPKLRPVSTQLYSAREKQQLASLVGTMLAYSLTYRQDRTPDGQYIYRLEPNVEEVCRFPELPARKPLTYQAKQLIAREVEVEKMRRVEASARARDGPQVDGGPPGGSGEKELQPPAPCNHKQRLECILKRAALEEQPERDFFGRVVVKRAAAPSTGGRTIVWPPQGTRPLRLTQLSGVWALQWAGATCGSASRRASPMPCGAACTSETCSRGHGEPLEPGRPPWAVLDTPTHAGRPQRVCWTL", "length": 1021, "header": "tr|E1B8Q4-1|E1B8Q4_BOVIN Isoform 1 of Chromosome transmission fidelity protein 18 homolog OS=Bos taurus OX=9913 GN=CHTF18 PE=3 SV=2 CANONICAL=E1B8Q4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S906-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4/entry#A0AAA9S906-1", "sequence": { "sequence": "MEDYELELYGVEDDFDSQFAAELEVLAELEGSAALSPSRDPRPTVGRPRQTFEEAIVGGDAAIHCSPGGPPRNSKGSVRKRHLAPDIQGDRSLPPAPHIKRSRLQAVRRLNFRSEEMEEMTPPDSPTLDITPPPSPEIPDELLGEGPLDSGADAGLTQASLATRNPVLRRPPVLEDYVNVTSTGGDRAFLVLRADPVGTGVQSPFHDTGWRGRGQLDLLGMPFTSLKEKVDSERRRRLLEEAQRLSDMLCSLRSQEVEEETQPSGAPEEEPADSQDASQHCLWVDEFAPQRYTELLSDDFTNRCLLKWLKLWDLVVFGREKPVQKPRPSAEPARGGKEATASSKWKSHEQVLEEMLEAELDPSGRPRQKVALLCGPPGLGKTTLAHVIARHAGYCVVEMNASDDRSPEAFRTRIEAATQMESVLGAGGRPNCLVIDEIDGAPTAAINVLLSVLDRKGPQQAGPGGPSVPTGGGRRRRAEAGLLMRPIICICNDPFAPSLRQLKQQALLLHFPPTLPSRLMQRLQEISLRRGMRADPGALAALCEKTDNDIRACINALQFLHRRGQRELSVQAVQSTRIGLKDQRKGLFSVWQEVFQLPRAQRRRVRQDSTLRTHMLLLGDQLSGSGPLAAEAPLTTAAQRFYHILHVAMSAGEHEKVVQGLFDNFLRMRLRDSSLGAVCTALDWLAFDDLLGRAALHSQSFQLMCYLPFLLPAFHLLFASSHVPRITFPSSQQEAQNRMNQTQNLIQTLVSGITPATRSWAAPQALILDTLCLLLDILTPKLRPERGGGLPLSRAACPQAPHLPGQAAHCPRGGSGEDAAGGGLGSGQGRPPGGWGSPGGLGGEGAAATCPMQPQAAAGVYPEESRPGGTAREGLLRSCGCQESSSPEHRARGP", "length": 894, "header": "tr|A0AAA9S906-1|E1B8Q4_BOVIN Computationally mapped isoform of Chromosome transmission fidelity protein 18 homolog OS=Bos taurus OX=9913 GN=CHTF18 PE=3 SV=1 CANONICAL=E1B8Q4-1" }, "locus": { "chromosome": "25", "start_pos": 677328, "end_pos": 669625, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119260.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119260.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082545.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082545.1" } ] } }, { "isoform_ac": "A0AAA9SXJ8-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4/entry#A0AAA9SXJ8-1", "sequence": { "sequence": "MEDYELELYGVEDDFDSQFAAELEVLAELEGSAALSPSRDPRPTVGRPRQTFEEAIVGGDAAIHCSPGGPPRNSKGSVRKRHLAPDIQGDRSLPPAPHIKRSRLQAVRRLNFRSEEMEEMTPPDSPTLDITPPPSPEIPDELLGEGPLDSGADAGLTQASLATRNPVLRRPPVLEDYVNVTSTGGDRAFLVLRADPVGTGVQSPFHDTGWRGRGQLDLLGMPFTSLKEKVDSERRRRLLEEAQRLSDMLCSLRSQEVEEETQPSGAPEEEPADSQDASQHCLWVDEFAPQRYTELLSDDFTNRCLLKWLKLWDLVVFGREKPVQKPRPSAEPARGGKEATASSKWKSHEQVLEEMLEAELDPSGRPRQKVALLCGPPGLGKTTLAHVIARHAGYCVVEMNASDDRSPEAFRTRIEAATQMESVLGAGGRPNCLVIDEIDGAPTAAINVLLSVLDRKGPQQAGPGGPSVPTGGGRRRRAEAGLLMRPIICICNDPFAPSLRQLKQQALLLHFPPTLPSRLMQRLQEISLRRGMRADPGALAALCEKTDNDIRACINALQFLHRRGQRELSVQAVQSTRIGLKDQRKGLFSVWQEVFQLPRAQRRRVRQDSTLRTHMLLLGDQLSGSGPLAAEAPLTTAAQRFYHILHVAMSAGEHEKVVQGLFDNFLRMRLRDSSLGAVCTALDWLAFDDLLGRAALHSQSFQLMCYLPFLLPAFHLLFASSHVPRITFPSSQQEAQNRMNQTQNLIQTLVSGITPATRSWAAPQALILDTLCLLLDILTPKLRPVSTQLYSAREKQQLASLVGTMLAYSLTYRQDRTPDGQYIYRLEPNVEEVCRFPELPARKPLTYQAKQLIAREVEVEKMRRVEASARARDGPQVDGGPPGGSGEKELQPPAPCNHKQRLECILKRAALEEQPERDFFGRVVVKRAAAPSTVTSLKHLESLPSAHFI", "length": 949, "header": "tr|A0AAA9SXJ8-1|E1B8Q4_BOVIN Computationally mapped isoform of Chromosome transmission fidelity protein 18 homolog OS=Bos taurus OX=9913 GN=CHTF18 PE=3 SV=1 CANONICAL=E1B8Q4-1" }, "locus": { "chromosome": "25", "start_pos": 683244, "end_pos": 669625, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098033.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098033.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091198.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091198.1" } ] } }, { "isoform_ac": "E1B8Q4-1", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4/entry#E1B8Q4-1", "sequence": { "sequence": "MEDYELELYGVEDDFDSQFAAELEVLAELEGSAALSPSRDPRPTVGRPRQTFEEAIVGGDAAIHCSPGGPPRNSKGSVRKRHLAPDIQGDRSLPPAPHIKRSRLQAVRRLNFRSEEMEEMTPPDSPTLDITPPPSPEIPDELLGEGPLDSGADAGLTQASLATRNPVLRRPPVLEDYVNVTSTGGDRAFLVLRADPVGTGVQSPFHDTGWRGRGQLDLLGMPFTSLKEKVDSERRRRLLEEAQRLSDMLCSLRSQEVEEETQPSGAPEEEPADSQDASQHCLWVDEFAPQRYTELLSDDFTNRCLLKWLKLWDLVVFGREKPVQKPRPSAEPARGGKEATASSKWKSHEQVLEEMLEAELDPSGRPRQKVALLCGPPGLGKTTLAHVIARHAGYCVVEMNASDDRSPEAFRTRIEAATQMESVLGAGGRPNCLVIDEIDGAPTAAINVLLSVLDRKGPQQAGPGGPSVPTGGGRRRRAEAGLLMRPIICICNDPFAPSLRQLKQQALLLHFPPTLPSRLMQRLQEISLRRGMRADPGALAALCEKTDNDIRACINALQFLHRRGQRELSVQAVQSTRIGLKDQRKGLFSVWQEVFQLPRAQRRRVRQDSTLRTHMLLLGDQLSGSGPLAAEAPLTTAAQRFYHILHVAMSAGEHEKVVQGLFDNFLRMRLRDSSLGAVCTALDWLAFDDLLGRAALHSQSFQLMCYLPFLLPAFHLLFASSHVPRITFPSSQQEAQNRMNQTQNLIQTLVSGITPATRSWAAPQALILDTLCLLLDILTPKLRPVSTQLYSAREKQQLASLVGTMLAYSLTYRQDRTPDGQYIYRLEPNVEEVCRFPELPARKPLTYQAKQLIAREVEVEKMRRVEASARARDGPQVDGGPPGGSGEKELQPPAPCNHKQRLECILKRAALEEQPERDFFGRVVVKRAAAPSTGGRTIVWPPQGTRPLRLTQLSGVWALQWAGATCGSASRRASPMPCGAACTSETCSRGHGEPLEPGRPPWAVLDTPTHAGRPQRVCWTL", "length": 1021, "header": "tr|E1B8Q4-1|E1B8Q4_BOVIN Isoform 1 of Chromosome transmission fidelity protein 18 homolog OS=Bos taurus OX=9913 GN=CHTF18 PE=3 SV=2 CANONICAL=E1B8Q4-1" }, "locus": { "chromosome": "25", "start_pos": 677549, "end_pos": 669625, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026311.8", "url": "https://www.ensembl.org/id/ENSBTAT00000026311.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026311.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026311.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 131, "start_aa": "Thr", "end_pos": 131, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr131", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 44, "start_aa": "Thr", "end_pos": 44, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr44", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-174411", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174411", "resource": "Reactome", "description": "Polymerase switching on the C-strand of the telomere" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q4", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q4", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q4", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4" } ], "pmid": "" }, { "name": "DNA clamp loader activity", "id": "GO:0003689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003689", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q4", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4" } ], "pmid": "" }, { "name": "single-stranded DNA helicase activity", "id": "GO:0017116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017116", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q4", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q4", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q4", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q4", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4" } ], "pmid": "" }, { "name": "Ctf18 RFC-like complex", "id": "GO:0031390", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031390", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q4", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "E1B8Q4", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" }, { "start_pos": 400, "end_pos": 402, "annotation": "n_glycosylation_sequon" }, { "start_pos": 740, "end_pos": 742, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8Q4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1021, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8Q4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8Q4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8Q4" }, { "id": "SM00382", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AAA+ ATPase", "eco_id": "ECO_0000259", "start_pos": 367, "end_pos": 525, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 44, 131 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 179, "end_pos": 181 }, { "start_pos": 400, "end_pos": 402 }, { "start_pos": 740, "end_pos": 742 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B7V8-1", "uniprot_ac": "E1B7V8", "uniprot_id": "E1B7V8_BOVIN", "mass": { "chemical_mass": 81617.0, "monoisotopic_mass": 81617.0 }, "refseq": {}, "gene_names": [ { "name": "PLEKHA4", "type": "recommended", "evidence": [ { "id": "E1B7V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7V8" } ] } ], "protein_names": [ { "name": "Pleckstrin homology domain containing A4", "type": "synonym", "evidence": [ { "id": "E1B7V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7V8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7V8", "url": "https://www.uniprot.org/uniprotkb/E1B7V8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLEKHA4", "url": "https://www.uniprot.org/uniprotkb/E1B7V8", "locus": { "chromosome": "18", "start_pos": 55447604, "end_pos": 55471334, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009177", "url": "https://www.ensembl.org/id/ENSBTAG00000009177" } ] } } ], "crossref": [ { "id": "E1B7V8", "url": "https://alphafold.ebi.ac.uk/entry/E1B7V8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009177", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009177", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13248", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13248", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510748", "url": "https://www.ncbi.nlm.nih.gov/gene/510748", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B7V8", "url": "https://www.orthodb.org/?gene=E1B7V8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12752", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12752", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12752:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12752:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25541", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25541", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1660499", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660499", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S942", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S942", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S942-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S942-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV89-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7V8", "url": "https://www.uniprot.org/uniprotkb/E1B7V8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7V8-1", "url": "https://www.uniprot.org/uniprotkb/E1B7V8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDGRPRSSLSLASSASTISSLSGLSTKDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYIIRPDGPGAPRGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDCGQPRSSARPQTGEGPGGPGGPPEVNRGTEEGRGSESPEVARLSRGRGRPGLLTPSPTADLQSGPRIRRTRSPDLFTPLSRPPSPPSLPRPRSAPARRPPPSSGDAAPSARPHTPLSRIDVRPPLDWGLQRQTLSRPPTPRRGPSSEARGGRPPRSPQHWSQEARTPVSRDAHSGTSTYLQLPPRPPGTRASMVILPGPPLDSTFHQSLETDTLLTKLCGQDRLLRRLQEEIDQRQEEKEQLEAALELTRQQLGQTTREAAAPGRAWGHQRLLQDRLVSVRATLCHLTQERERVWDTYSSLERELGTLRETLEYLLHLGSPQDRASAQQQLWMVEDTLAGLGGPQKPPSNTEPDSPSPALQGEESSERESLTESLELSSSRSPEVDWGRPPGGDRELSIPRSGIVSPRVSRASSPEGRRPTSPQPGTKVPLARPRMSAQEQLERIRRNQECGLPLPRPASPRLLTLGRTLSPARRQPDAEQKPVLGHSGAQKWLRSSGSWSSPRNTTPYLLTSEGHRERVLSLSQALAAEASQWRGMMTGGNLDCRGDPLPPAPPPRSDPTPQASSPRRSPPTANSCSTGFSPRGSGRGAGPASWEQTWDSEPAPPALTPDEGAWPLRVTLLQSSF", "length": 748, "header": "tr|E1B7V8-1|E1B7V8_BOVIN Isoform 1 of Pleckstrin homology domain containing A4 OS=Bos taurus OX=9913 GN=PLEKHA4 PE=4 SV=4 CANONICAL=E1B7V8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S942-1", "url": "https://www.uniprot.org/uniprotkb/E1B7V8/entry#A0AAA9S942-1", "sequence": { "sequence": "MEDGRPRSSLSLASSASTISSLSGLSTKKSTRAVSKVHAFGKRGNALRRDPNLPVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYIIRPDGPGAPRGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDCGQPRSSARPQTGEGPGGPGGPPEVNRGTEEGRGSESPEVARLSRGRGRPGLLTPSPTADLQSGPRIRRTRSPDLFTPLSRPPSPPSLPRPRSAPARRPPPSSGDAAPSARPHTPLSRIDVRPPLDWGLQRQTLSRPPTPRRGPSSEARGGRPPRSPQHWSQEARTPAHSGTSTYLQLPPRPPGTRASMVILPGPPLDSTFHQSLETDTLLTKLCGQDRLLRRLQEEIDQRQEEKEQLEAALELTRQQLGQTTREAAAPGRAWGHQRLLQDRLVSVRATLCHLTQERERVWDTYSSLERELGTLRETLEYLLHLGSPQDRASAQQQLWMVEDTLAGLGGPQKPPSNTEPDSPSPALQGEESSERESLTESLELSSSRSPEVDWGRPPGGDRELSIPRSGIVSPRVSRASSPEGRRPTSPQPGTKPVLGHSGAQKWLRSSGSWSSPRNTTPYLLTSEGHRERVLSLSQALAAEASQWRGMMTGGNLDCRGDPLPPAPPPRSDPTPQASSPRRSPPTANSCSTGFSPRGSGRGAGPASWEQTWDSEPAPPALTPDEGAWPLRVTLLQSSF", "length": 726, "header": "tr|A0AAA9S942-1|E1B7V8_BOVIN Computationally mapped isoform of Pleckstrin homology domain containing A4 OS=Bos taurus OX=9913 GN=PLEKHA4 PE=4 SV=1 CANONICAL=E1B7V8-1" }, "locus": { "chromosome": "18", "start_pos": 55471328, "end_pos": 55448078, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129510.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129510.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081806.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081806.1" } ] } }, { "isoform_ac": "A0AAA9SR71-1", "url": "https://www.uniprot.org/uniprotkb/E1B7V8/entry#A0AAA9SR71-1", "sequence": { "sequence": "MEDGRPRSSLSLASSASTISSLSGLSTKKSTRAVSKVHAFGKRGNALRRDPNLPVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYIIRPDGPGAPRGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDCGQPRSSARPQTGEGPGGPGGPPEVNRGTEEGRGSESPEVARLSRGRGRPGLLTPSPTADLQSGPRIRRTRSPDLFTPLSRPPSPPSLPRPRSAPARRPPPSSGDAAPSARPHTPLSRIDVRPPLDWGLQRQTLSRPPTPRRGPSSEARGGRPPRSPQHWSQEARTPPGPPLDSTFHQSLETDTLLTKLCGQDRLLRRLQEEIDQRQEEKEQLEAALELTRQQLGQTTREAAAPGRAWGHQRLLQDRLVSVRATLCHLTQERERVWDTYSSLERELGTLRETLEYLLHLGSPQDRASAQQQLWMVEDTLAGLGGPQKPPSNTEPDSPSPALQGEESSERESLTESLELSSSRSPEVDWGRPPGGDRELSIPRSGIVSPRVSRASSPEGRRPTSPQPGTKSKEHHPLFADIRRAPGASPQPLSSTGR", "length": 584, "header": "tr|A0AAA9SR71-1|E1B7V8_BOVIN Computationally mapped isoform of Pleckstrin homology domain containing A4 OS=Bos taurus OX=9913 GN=PLEKHA4 PE=4 SV=1 CANONICAL=E1B7V8-1" }, "locus": { "chromosome": "18", "start_pos": 55471328, "end_pos": 55448692, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121169.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121169.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086558.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086558.1" } ] } }, { "isoform_ac": "A0AAA9TV89-1", "url": "https://www.uniprot.org/uniprotkb/E1B7V8/entry#A0AAA9TV89-1", "sequence": { "sequence": "MEDGRPRSSLSLASSASTISSLSGLSTKKSTRAVSKVHAFGKRGNALRRDPNLPVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYIIRPDGPGAPRGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDCGQPRSSARPQTGEGPGGPGGPPEVNRGTEEGRGSESPEVARLSRGRGRPGLLTPSPTADLQSGPRIRRTRSPDLFTPLSRPPSPPSLPRPRSAPARRPPPSSGDAAPSARPHTPLSRIDVRPPLDWGLQRQTLSRPPTPRRGPSSEARGGRPPRSPQHWSQEARTPAHSGTSTYLQLPPRPPGTRASMVILPGPPLDSTFHQSLETDTLLTKLCGQDRLLRRLQEEIDQRQEEKEQLEAALELTRQQLGQTTREAAAPGRAWGHQRLLQDRLVSVRATLCHLTQERERVWDTYSSLERELGTLRETLEYLLHLGSPQDRASAQQQLWMVEDTLAGLGGPQKPPSNTEPDSPSPALQGEESSEREVPLARPRMSAQEQLERIRRNQECGLPLPRPASPRLLTLGRTLSPARRQPDAEQKPVLGHSGAQKWLRSSGSWSSPRNTTPYLLTSEGHRERVLSLSQALAAEASQWRGMMTGGNLDCRGDPLPPAPPPRSDPTPQASSPRRSPPTANSCSTGFSPRGSGRGAGPASWEQTWDSEPAPPALTPDEGAWPLRVTLLQSSF", "length": 721, "header": "tr|A0AAA9TV89-1|E1B7V8_BOVIN Computationally mapped isoform of Pleckstrin homology domain containing A4 OS=Bos taurus OX=9913 GN=PLEKHA4 PE=4 SV=1 CANONICAL=E1B7V8-1" }, "locus": { "chromosome": "18", "start_pos": 55471328, "end_pos": 55448078, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112206.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112206.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102535.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102535.1" } ] } }, { "isoform_ac": "E1B7V8-1", "url": "https://www.uniprot.org/uniprotkb/E1B7V8/entry#E1B7V8-1", "sequence": { "sequence": "MEDGRPRSSLSLASSASTISSLSGLSTKDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYIIRPDGPGAPRGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDCGQPRSSARPQTGEGPGGPGGPPEVNRGTEEGRGSESPEVARLSRGRGRPGLLTPSPTADLQSGPRIRRTRSPDLFTPLSRPPSPPSLPRPRSAPARRPPPSSGDAAPSARPHTPLSRIDVRPPLDWGLQRQTLSRPPTPRRGPSSEARGGRPPRSPQHWSQEARTPVSRDAHSGTSTYLQLPPRPPGTRASMVILPGPPLDSTFHQSLETDTLLTKLCGQDRLLRRLQEEIDQRQEEKEQLEAALELTRQQLGQTTREAAAPGRAWGHQRLLQDRLVSVRATLCHLTQERERVWDTYSSLERELGTLRETLEYLLHLGSPQDRASAQQQLWMVEDTLAGLGGPQKPPSNTEPDSPSPALQGEESSERESLTESLELSSSRSPEVDWGRPPGGDRELSIPRSGIVSPRVSRASSPEGRRPTSPQPGTKVPLARPRMSAQEQLERIRRNQECGLPLPRPASPRLLTLGRTLSPARRQPDAEQKPVLGHSGAQKWLRSSGSWSSPRNTTPYLLTSEGHRERVLSLSQALAAEASQWRGMMTGGNLDCRGDPLPPAPPPRSDPTPQASSPRRSPPTANSCSTGFSPRGSGRGAGPASWEQTWDSEPAPPALTPDEGAWPLRVTLLQSSF", "length": 748, "header": "tr|E1B7V8-1|E1B7V8_BOVIN Isoform 1 of Pleckstrin homology domain containing A4 OS=Bos taurus OX=9913 GN=PLEKHA4 PE=4 SV=4 CANONICAL=E1B7V8-1" }, "locus": { "chromosome": "18", "start_pos": 55471328, "end_pos": 55448078, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061135.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061135.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053170.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053170.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1660499", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660499", "resource": "Reactome", "description": "Synthesis of PIPs at the plasma membrane" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B7V8", "url": "https://www.uniprot.org/uniprotkb/E1B7V8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1B7V8", "url": "https://www.uniprot.org/uniprotkb/E1B7V8" } ], "pmid": "" }, { "name": "extrinsic component of cytoplasmic side of plasma membrane", "id": "GO:0031234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031234", "evidence": [ { "database": "UniProtKB", "id": "E1B7V8", "url": "https://www.uniprot.org/uniprotkb/E1B7V8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "phosphatidylinositol-4,5-bisphosphate binding", "id": "GO:0005546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", "evidence": [ { "database": "UniProtKB", "id": "E1B7V8", "url": "https://www.uniprot.org/uniprotkb/E1B7V8" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,4-bisphosphate binding", "id": "GO:0043325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043325", "evidence": [ { "database": "UniProtKB", "id": "E1B7V8", "url": "https://www.uniprot.org/uniprotkb/E1B7V8" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,5-bisphosphate binding", "id": "GO:0080025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080025", "evidence": [ { "database": "UniProtKB", "id": "E1B7V8", "url": "https://www.uniprot.org/uniprotkb/E1B7V8" } ], "pmid": "" }, { "name": "phosphatidylinositol-3-phosphate binding", "id": "GO:0032266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032266", "evidence": [ { "database": "UniProtKB", "id": "E1B7V8", "url": "https://www.uniprot.org/uniprotkb/E1B7V8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of Wnt signaling pathway, planar cell polarity pathway", "id": "GO:2000096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000096", "evidence": [ { "database": "UniProtKB", "id": "E1B7V8", "url": "https://www.uniprot.org/uniprotkb/E1B7V8" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "E1B7V8", "url": "https://www.uniprot.org/uniprotkb/E1B7V8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 627, "end_pos": 629, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7V8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 748, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7V8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7V8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7V8" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 18, "end_pos": 117, "start_aa": "Thr", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 627, "end_pos": 629 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDG6-1", "uniprot_ac": "E1BDG6", "uniprot_id": "E1BDG6_BOVIN", "mass": { "chemical_mass": 72045.0, "monoisotopic_mass": 72045.0 }, "refseq": { "ac": "XP_024836425", "name": "rab11 family-interacting protein 4 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836425" }, "gene_names": [ { "name": "RAB11FIP4", "type": "recommended", "evidence": [ { "id": "E1BDG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG6" } ] }, { "name": "RAB11FIP4", "type": "synonym", "evidence": [ { "id": "XP_024836425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836425" } ] } ], "protein_names": [ { "name": "Rab11 family-interacting protein 4", "type": "recommended", "evidence": [ { "id": "E1BDG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG6/entry#names_and_taxonomy" } ] }, { "name": "rab11 family-interacting protein 4 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024836425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836425" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDG6", "url": "https://www.uniprot.org/uniprotkb/E1BDG6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAB11FIP4", "url": "https://www.uniprot.org/uniprotkb/E1BDG6", "locus": { "chromosome": "19", "start_pos": 18500131, "end_pos": 18602788, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016972", "url": "https://www.ensembl.org/id/ENSBTAG00000016972" } ] } } ], "crossref": [ { "id": "E1BDG6", "url": "https://alphafold.ebi.ac.uk/entry/E1BDG6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016972", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016972", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100848380", "url": "https://www.ncbi.nlm.nih.gov/gene/100848380", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019018", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019018", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057316", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057316", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100848380", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848380", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR15726", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15726", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15726:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15726:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09457", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09457", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25450", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25450", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024836425", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836425", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S9J6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9J6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9J6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9J6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDG6", "url": "https://www.uniprot.org/uniprotkb/E1BDG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDG6-1", "url": "https://www.uniprot.org/uniprotkb/E1BDG6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGGAGWAGAPAALLRSVRRLREVFEVCGRDPDGFLRVERVAALGLRFGQGEEVEKLVKYLDPNDLGRINFKDFCRGVFAMKGCEELLKDVLSVESAGTLPCAPEIPDCVEQGSEVPDPTFADGELLPTEPDFFPEDEDEAMTLAPPEGPQESDMEGPMESTRSLEGPVGIPAEKDAGLGGLFLPEDKSLGHPPSVTTSDLSTHSTTSLISNEEQFEDYGEADDVDCAPSSPCPDDETRTNVYSDLGSSVSSSAGQTPRKMRHAYNSELLDVYCSQCCKKINLLNDLEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYSKLERERSTEIELLTTRVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRHNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSSSSSLGEFNARAREVELEHEVKRLKQENHKLRDQNDDLNGQILSLSLYEAKNLFATQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKIILAILDHNPSILEIKH", "length": 637, "header": "tr|E1BDG6-1|E1BDG6_BOVIN Isoform 1 of Rab11 family-interacting protein 4 OS=Bos taurus OX=9913 GN=RAB11FIP4 PE=4 SV=3 CANONICAL=E1BDG6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9J6-1", "url": "https://www.uniprot.org/uniprotkb/E1BDG6/entry#A0AAA9S9J6-1", "sequence": { "sequence": "MRTPPAPGGQGSEVPDPTFADGELLPTEPDFFPEDEDEAMTLAPPEGPQESDMEGPMESTRSLEGPVGIPAEKDAGLGGLFLPEDKSLGHPPSVTTSDLSTHSTTSLISNEEQFEDYGEADDVDCAPSSPCPDDETRTNVYSDLGSSVSSSAGQTPRKMRHAYNSELLDVYCSQCCKKINLLNDLEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYSKLERERSTEIELLTTRVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRHNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSSSSSLGEFNARAREVELEHEVKRLKQENHKLRDQNDDLNGQILSLSLYEAKNLFATQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKIILAILDHNPSILEIKH", "length": 535, "header": "tr|A0AAA9S9J6-1|E1BDG6_BOVIN Computationally mapped isoform of Rab11 family-interacting protein 4 OS=Bos taurus OX=9913 GN=RAB11FIP4 PE=4 SV=1 CANONICAL=E1BDG6-1" }, "locus": { "chromosome": "19", "start_pos": 18536120, "end_pos": 18501135, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103249.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103249.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078813.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078813.1" } ] } }, { "isoform_ac": "E1BDG6-1", "url": "https://www.uniprot.org/uniprotkb/E1BDG6/entry#E1BDG6-1", "sequence": { "sequence": "MAGGAGWAGAPAALLRSVRRLREVFEVCGRDPDGFLRVERVAALGLRFGQGEEVEKLVKYLDPNDLGRINFKDFCRGVFAMKGCEELLKDVLSVESAGTLPCAPEIPDCVEQGSEVPDPTFADGELLPTEPDFFPEDEDEAMTLAPPEGPQESDMEGPMESTRSLEGPVGIPAEKDAGLGGLFLPEDKSLGHPPSVTTSDLSTHSTTSLISNEEQFEDYGEADDVDCAPSSPCPDDETRTNVYSDLGSSVSSSAGQTPRKMRHAYNSELLDVYCSQCCKKINLLNDLEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYSKLERERSTEIELLTTRVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRHNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSSSSSLGEFNARAREVELEHEVKRLKQENHKLRDQNDDLNGQILSLSLYEAKNLFATQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKIILAILDHNPSILEIKH", "length": 637, "header": "tr|E1BDG6-1|E1BDG6_BOVIN Isoform 1 of Rab11 family-interacting protein 4 OS=Bos taurus OX=9913 GN=RAB11FIP4 PE=4 SV=3 CANONICAL=E1BDG6-1" }, "locus": { "chromosome": "19", "start_pos": 18602731, "end_pos": 18501135, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022573.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022573.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022573.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022573.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100848380", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848380", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "recycling endosome membrane", "id": "GO:0055038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055038", "evidence": [ { "database": "UniProtKB", "id": "E1BDG6", "url": "https://www.uniprot.org/uniprotkb/E1BDG6" } ], "pmid": "" }, { "name": "cleavage furrow", "id": "GO:0032154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032154", "evidence": [ { "database": "UniProtKB", "id": "E1BDG6", "url": "https://www.uniprot.org/uniprotkb/E1BDG6" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "E1BDG6", "url": "https://www.uniprot.org/uniprotkb/E1BDG6" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "E1BDG6", "url": "https://www.uniprot.org/uniprotkb/E1BDG6" } ], "pmid": "" }, { "name": "endocytic vesicle", "id": "GO:0030139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030139", "evidence": [ { "database": "UniProtKB", "id": "E1BDG6", "url": "https://www.uniprot.org/uniprotkb/E1BDG6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "E1BDG6", "url": "https://www.uniprot.org/uniprotkb/E1BDG6" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "E1BDG6", "url": "https://www.uniprot.org/uniprotkb/E1BDG6" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "E1BDG6", "url": "https://www.uniprot.org/uniprotkb/E1BDG6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "endocytic recycling", "id": "GO:0032456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032456", "evidence": [ { "database": "UniProtKB", "id": "E1BDG6", "url": "https://www.uniprot.org/uniprotkb/E1BDG6" } ], "pmid": "" }, { "name": "regulation of cytokinesis", "id": "GO:0032465", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032465", "evidence": [ { "database": "UniProtKB", "id": "E1BDG6", "url": "https://www.uniprot.org/uniprotkb/E1BDG6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 322, "end_pos": 324, "annotation": "n_glycosylation_sequon" }, { "start_pos": 356, "end_pos": 358, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDG6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 637, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDG6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDG6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG6" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 49, "end_pos": 84, "start_aa": "Gly", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BDG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG6" }, { "id": "PS51511", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51511" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FIP-RBD", "eco_id": "ECO_0000259", "start_pos": 574, "end_pos": 636, "start_aa": "Glu", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 317, "end_pos": 319 }, { "start_pos": 322, "end_pos": 324 }, { "start_pos": 356, "end_pos": 358 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDC2-1", "uniprot_ac": "E1BDC2", "uniprot_id": "E1BDC2_BOVIN", "mass": { "chemical_mass": 101599.0, "monoisotopic_mass": 101599.0 }, "refseq": { "ac": "XP_002688485", "name": "DNA polymerase nu", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688485" }, "gene_names": [ { "name": "POLN", "type": "recommended", "evidence": [ { "id": "E1BDC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDC2" } ] }, { "name": "POLN", "type": "synonym", "evidence": [ { "id": "XP_002688485", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688485" } ] } ], "protein_names": [ { "name": "DNA-directed DNA polymerase", "type": "recommended", "evidence": [ { "id": "E1BDC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDC2/entry#names_and_taxonomy" } ] }, { "name": "2.7.7.7", "type": "synonym", "evidence": [ { "id": "E1BDC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDC2/entry#names_and_taxonomy" } ] }, { "name": "DNA polymerase nu", "type": "synonym", "evidence": [ { "id": "XP_002688485", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688485" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDC2", "url": "https://www.uniprot.org/uniprotkb/E1BDC2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "POLN", "url": "https://www.uniprot.org/uniprotkb/E1BDC2", "locus": { "chromosome": "6", "start_pos": 116589660, "end_pos": 116437291, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017296", "url": "https://www.ensembl.org/id/ENSBTAG00000017296" } ] } } ], "crossref": [ { "id": "E1BDC2", "url": "https://alphafold.ebi.ac.uk/entry/E1BDC2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017296", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017296", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08638", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08638", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523362", "url": "https://www.ncbi.nlm.nih.gov/gene/523362", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002298", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002298", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523362", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523362", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RFLIMSN", "url": "https://omabrowser.org/oma/group/RFLIMSN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BDC2", "url": "https://www.orthodb.org/?gene=E1BDC2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10133", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10133", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10133:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10133:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00476", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00476", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18049", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18049", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6783310", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6783310", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002688485", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688485", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "22508", "url": "https://www.rhea-db.org/rhea/22508", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SAK0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAK0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAK0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDC2", "url": "https://www.uniprot.org/uniprotkb/E1BDC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDC2-1", "url": "https://www.uniprot.org/uniprotkb/E1BDC2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVQESAAQLSMTPKVQEYPTLKDFMKMENYEAFVGSDLCKIPLSSVAQKIMSAMHSGDLVESETWRESENTADVVDKSSVKYSVLLEDGKDQSLEKKNPNLLTSQPSGVSIKFCPESSGIRVTDQLSADQSQKGISSSAPSRCSVPQCDQQASVLQKMECKRKHLPKENNRESLNLTGNHVSCSSSSAKTSKLVILEEDAGEVETYLSSRHAKAFKTDFCDIRHLDALEQSQLIEMLKQAATLVVTLMYKDGSTQLRADQALVSSVKGIVMLLRRHPEEGSGGLAASASDSVPEDVPSDQCIYIKTERSSAWGQGQEAQHQLAENVLREVLRRKRPVICFNAKDFVRTALQLFGDDGSWKCVAGFVGLDPRIAAWLIDPSDAAPSFEDLVAKYLGNPTTLTVNSMHGNSSRKTVNQTVRAKLRVLHRLTMHLCSQLQVCGLWQLFWTLELPLIPILAVMESHRIRVNKEEMERMSALLGSRLKELEQEAHFVAGEQFLITSNHQLREILFGKLRLHLLRPQDASPATGLRRLPSTSGAELNALQDLHPLPRIILEYRQVHKIKSTFVDGLLACMKKGSVSSTWNQTGTVSGRLSAKHPNIQGISKHPIQITKPQSFKGEEDELSISPRTAFVSSEGYTFLAADFSQIELRILAHLSGDPELLKLFQESERDDVFSTLTSQWKDVSPERVTHADREQTKKVVYAVVYGAGKERLAACLGVPVREAARFLESFLQKYKKIKDFTQATVARCQQTGYVESIMGRRRPLPRIRAHDPQLRAQAERQAANFVVQGSAADLCKMAMIRIFTAMATSPTLTARLLAQIHDELLFEVEDSQVPEFTALVQGTMEALQHVPALELQLQVPLKVSLSAGRSWGHLVPLQGAPGPTNVPPSLQATSGPRPAPERRPPRLHFLPSFGP", "length": 917, "header": "tr|E1BDC2-1|E1BDC2_BOVIN Isoform 1 of DNA-directed DNA polymerase OS=Bos taurus OX=9913 GN=POLN PE=3 SV=3 CANONICAL=E1BDC2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAK0-1", "url": "https://www.uniprot.org/uniprotkb/E1BDC2/entry#A0AAA9SAK0-1", "sequence": { "sequence": "MAVQESAAQLSMTPKVQEYPTLKDFMKMENYEAFVGSDLCKIPLSSVAQKIMSAMHSGDLVESETWRESENTADVVDKSSVKYSVLLEDGKDQSLEKKNPNLLTSQPSGVSIKFCPESSGIRVTDQLSADQSQKGISSSAPSRCSVPQCDQQASVLQKMECKRKHLPKENNRESLNLTGNHVSCSSSSAKTSKLVILEEDAGEVETYLSSRHAKAFKTDFCDIRHLDALEQSQLIEMLKQAATLVVTLMYKDGSTQLRADQALVSSVKGIVMLLRRHPEEGSGGLAASASDSVPEDVPSDQCIYIKTERSSAWGQGQEAQHQLAENVLREVLRRKRPVICFNAKDFVRTALQLFGDDGSWKCVAGFVGLDPRIAAWLIDPSDAAPSFEDLVAKYLGNPTTLTVNSMHGNSSRKTVNQTVRAKLRVLHRLTMHLCSQLQVCGLWQLFWTLELPLIPILAVMESHRIRVNKEEMERMSALLGSRLKELEQEAHFVAGEQFLITSNHQLREILFGKLRLHLLRPQDASPATGLRRLPSTSGAELNALQDLHPLPRIILEYRQVHKIKSTFVDGLLACMKKGSVSSTWNQTGTVSGRLSAKHPVSQRWWSARLCVRNIQGISKHPIQITKPQSFKGEEDELSISPRTAFVSSEGYTFLAADFSQIELRILAHLSGDPELLKLFQESERDDVFSTLTSQWKDVSPERVTHADREQTKKVVYAVVYGAGKERLAACLGVPVREAARFLESFLQKYKKIKDFTQATVARCQQTGYVESIMGRRRPLPRIRAHDPQLRAQAERQAANFVVQGSAADLCKMAMIRIFTAMATSPTLTASMSPAVRTAGPLPCRRWDRGPAGTQRPFGTQGPAGAGDLCLGLPSLQSSLCPGASGALTSSGAPTSKVKDASLT", "length": 903, "header": "tr|A0AAA9SAK0-1|E1BDC2_BOVIN Computationally mapped isoform of DNA-directed DNA polymerase OS=Bos taurus OX=9913 GN=POLN PE=3 SV=2 CANONICAL=E1BDC2-1" }, "locus": { "chromosome": "6", "start_pos": 116576972, "end_pos": 116437411, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114757.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114757.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082365.2", "url": "https://www.ensembl.org/id/ENSBTAP00000082365.2" } ] } }, { "isoform_ac": "E1BDC2-1", "url": "https://www.uniprot.org/uniprotkb/E1BDC2/entry#E1BDC2-1", "sequence": { "sequence": "MAVQESAAQLSMTPKVQEYPTLKDFMKMENYEAFVGSDLCKIPLSSVAQKIMSAMHSGDLVESETWRESENTADVVDKSSVKYSVLLEDGKDQSLEKKNPNLLTSQPSGVSIKFCPESSGIRVTDQLSADQSQKGISSSAPSRCSVPQCDQQASVLQKMECKRKHLPKENNRESLNLTGNHVSCSSSSAKTSKLVILEEDAGEVETYLSSRHAKAFKTDFCDIRHLDALEQSQLIEMLKQAATLVVTLMYKDGSTQLRADQALVSSVKGIVMLLRRHPEEGSGGLAASASDSVPEDVPSDQCIYIKTERSSAWGQGQEAQHQLAENVLREVLRRKRPVICFNAKDFVRTALQLFGDDGSWKCVAGFVGLDPRIAAWLIDPSDAAPSFEDLVAKYLGNPTTLTVNSMHGNSSRKTVNQTVRAKLRVLHRLTMHLCSQLQVCGLWQLFWTLELPLIPILAVMESHRIRVNKEEMERMSALLGSRLKELEQEAHFVAGEQFLITSNHQLREILFGKLRLHLLRPQDASPATGLRRLPSTSGAELNALQDLHPLPRIILEYRQVHKIKSTFVDGLLACMKKGSVSSTWNQTGTVSGRLSAKHPNIQGISKHPIQITKPQSFKGEEDELSISPRTAFVSSEGYTFLAADFSQIELRILAHLSGDPELLKLFQESERDDVFSTLTSQWKDVSPERVTHADREQTKKVVYAVVYGAGKERLAACLGVPVREAARFLESFLQKYKKIKDFTQATVARCQQTGYVESIMGRRRPLPRIRAHDPQLRAQAERQAANFVVQGSAADLCKMAMIRIFTAMATSPTLTARLLAQIHDELLFEVEDSQVPEFTALVQGTMEALQHVPALELQLQVPLKVSLSAGRSWGHLVPLQGAPGPTNVPPSLQATSGPRPAPERRPPRLHFLPSFGP", "length": 917, "header": "tr|E1BDC2-1|E1BDC2_BOVIN Isoform 1 of DNA-directed DNA polymerase OS=Bos taurus OX=9913 GN=POLN PE=3 SV=3 CANONICAL=E1BDC2-1" }, "locus": { "chromosome": "6", "start_pos": 116589288, "end_pos": 116437411, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023023.7", "url": "https://www.ensembl.org/id/ENSBTAT00000023023.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023023.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023023.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:523362", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523362", "resource": "KEGG Pathway" }, { "id": "R-BTA-6783310", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6783310", "resource": "Reactome", "description": "Fanconi Anemia Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q7TQ07-1", "protein_name": "DNA polymerase nu", "gene_name": "Poln", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MENYEACVGFDVCEIPLSAVAQKIMSAMRSGDFMDSRNEGESTNTSKVAKKSSVHYSVLAEHEETQSLGTKNPESLITQTPRGSIELCPQPSITKLTCQLSAGQVQNSISSLGLSSYLIPQCDQEASVLPNMEHKRQHFLKENIGKEDKDNSSLKRKYITCSKSSEKASKHTALEKDTDGTESWPNSRDTRALGERLCDVRYLGDLAKAQLMDALKQAAALVVTLMYKDGSTQLSAKEALTCTVKGIVVLLKSHVGNSTLTLPAHGGALEKDFISEDHCVYIHTEHSPFWDPKQEAHSLFVRNILFWTLRCKCPVVCFNAKDFVRTVLQLYGEDGSWKHVADFVGLDPRVAAWLIDPSDTAPSFEDLVAKHLEKSITVKPSSTFREASRNTLSQNVFMNLKILYDLTMDLCSKLKAYGLWQLFCTLELPLIPILAVMENHKIPVDKEEMERTSALLGARLKELEQEAHFVAGEQFLIMSNNQLREILFGKLKLHLLSQRKHLPRTGLQNQLSTSEAMLNSLQDLHPLPKLILEYRQVHKIKSTFIDGLLAYMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIKISKPWNFKGKEEETVTISPRTLFVSSEGHTFLAADFSQIELRILAHLSGDPELLKLFQESERDDVFSTLTSQWKDIPIERVTHMDREQTKKVVYSVVYGAGKERLAACLGVTVLEATHFLERFLQKYKKIKDFAQTVIGQCHSAGYVTSILGRRRPLPRICAQDQQLRAQAERQAVNFVVQGSAADLCKLAMIRISTAVATSPTLTARLVAQIHDELLFEVEDTQVPEFAALVRRIMESLQQVQTLELQLQVPLKVNLSVGRSWGHLTPLQEILGSA", "length": 864 }, "evidence": [ { "id": "E1BDC2", "url": "https://omabrowser.org/oma/group/E1BDC2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7Z5Q5-1", "protein_name": "DNA polymerase nu", "gene_name": "POLN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MENYEALVGFDLCNTPLSSVAQKIMSAMHSGDLVDSKTWGKSTETMEVINKSSVKYSVQLEDRKTQSPEKKDLKSLRSQTSRGSAKLSPQSFSVRLTDQLSADQKQKSISSLTLSSCLIPQYNQEASVLQKKGHKRKHFLMENINNENKGSINLKRKHITYNNLSEKTSKQMALEEDTDDAEGYLNSGNSGALKKHFCDIRHLDDWAKSQLIEMLKQAAALVITVMYTDGSTQLGADQTPVSSVRGIVVLVKRQAEGGHGCPDAPACGPVLEGFVSDDPCIYIQIEHSAIWDQEQEAHQQFARNVLFQTMKCKCPVICFNAKDFVRIVLQFFGNDGSWKHVADFIGLDPRIAAWLIDPSDATPSFEDLVEKYCEKSITVKVNSTYGNSSRNIVNQNVRENLKTLYRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHLVPLQEAWGPPPGPCRTESPSNSLAAPGSPASTQPPPLHFSPSFCL", "length": 900 }, "evidence": [ { "id": "E1BDC2", "url": "https://omabrowser.org/oma/group/E1BDC2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA-directed DNA polymerase activity", "id": "GO:0003887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003887", "evidence": [ { "database": "UniProtKB", "id": "E1BDC2", "url": "https://www.uniprot.org/uniprotkb/E1BDC2" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BDC2", "url": "https://www.uniprot.org/uniprotkb/E1BDC2" } ], "pmid": "" }, { "name": "cyclin binding", "id": "GO:0030332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030332", "evidence": [ { "database": "UniProtKB", "id": "E1BDC2", "url": "https://www.uniprot.org/uniprotkb/E1BDC2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "E1BDC2", "url": "https://www.uniprot.org/uniprotkb/E1BDC2" } ], "pmid": "" }, { "name": "DNA-templated DNA replication", "id": "GO:0006261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006261", "evidence": [ { "database": "UniProtKB", "id": "E1BDC2", "url": "https://www.uniprot.org/uniprotkb/E1BDC2" } ], "pmid": "" }, { "name": "double-strand break repair", "id": "GO:0006302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006302", "evidence": [ { "database": "UniProtKB", "id": "E1BDC2", "url": "https://www.uniprot.org/uniprotkb/E1BDC2" } ], "pmid": "" }, { "name": "double-strand break repair via homologous recombination", "id": "GO:0000724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000724", "evidence": [ { "database": "UniProtKB", "id": "E1BDC2", "url": "https://www.uniprot.org/uniprotkb/E1BDC2" } ], "pmid": "" }, { "name": "interstrand cross-link repair", "id": "GO:0036297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036297", "evidence": [ { "database": "UniProtKB", "id": "E1BDC2", "url": "https://www.uniprot.org/uniprotkb/E1BDC2" } ], "pmid": "" }, { "name": "translesion synthesis", "id": "GO:0019985", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019985", "evidence": [ { "database": "UniProtKB", "id": "E1BDC2", "url": "https://www.uniprot.org/uniprotkb/E1BDC2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BDC2", "url": "https://www.uniprot.org/uniprotkb/E1BDC2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 409, "end_pos": 411, "annotation": "n_glycosylation_sequon" }, { "start_pos": 416, "end_pos": 418, "annotation": "n_glycosylation_sequon" }, { "start_pos": 585, "end_pos": 587, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "22508", "name": "", "equation": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BHH1-1", "A0A3Q1M493-1", "E1BPY8-1", "Q08DZ8-1", "Q27958-1", "E1BNZ6-1", "A0AAA9SFP0-1", "A0AAA9THK8-1", "P06526-1", "P28339-1", "Q27ID4-1", "A0AAA9STI1-1", "F1MPJ5-1", "A0AAA9RXS9-1", "E1BDI3-1", "E1BDC2-1", "F1MZ79-1", "A0ABI0NXT5-1" ], "evidence": [ { "id": "22508", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22508" } ] }, { "id": "R-BTA-6786155", "name": "POLN binds ICL-DNA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BDC2-1" ], "evidence": [ { "id": "R-BTA-6786155", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6786155" } ] }, { "id": "R-BTA-6786166", "name": "Translesion synthesis across unhooked ICL by POLN", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-ALL-5688114", "R-ALL-75165", "R-BTA-6786153" ], "enzyme_list": [ "E1BDC2-1" ], "evidence": [ { "id": "R-BTA-6786166", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6786166" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-5688114", "participant_name": "Distorted dsDNA [nucleoplasm]", "crossref": [ { "id": "61120", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-75165", "participant_name": "DNA double-strand break ends [nucleoplasm]", "crossref": [ { "id": "61120", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-BTA-6786153", "participant_name": "POLN [nucleoplasm]", "crossref": [ { "id": "XP_002688485.4", "database": "RefSeq", "url": "" }, { "id": "E1BDC2", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000023023", "database": "ENSEMBL", "url": "" }, { "id": "33129", "database": "VGNC", "url": "" }, { "id": "ENSBTAT00000023023", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000017296", "database": "ENSEMBL", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0AAA9RXS9", "gene_name": "POLK", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0AAA9RXS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXS9" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0AAA9RXS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXS9" } ] } ] }, { "uniprot_ac": "A0AAA9SFP0", "gene_name": "POLE", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0AAA9SFP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFP0" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0AAA9SFP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFP0" } ] } ] }, { "uniprot_ac": "A0AAA9STI1", "gene_name": "TERT", "activity": [ { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0AAA9STI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI1" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0AAA9STI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STI1" } ] } ] }, { "uniprot_ac": "A0AAA9THK8", "gene_name": "POLA1", "activity": [ { "ec_number": "2.7.7.7", "activity": 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Classification", "Other" ] }, { "id": "XP_005201434", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201434", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SAM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN22-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7P3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7P3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7P3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7P3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTG9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB04", "url": "https://www.uniprot.org/uniprotkb/E1BB04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB04-1", "url": "https://www.uniprot.org/uniprotkb/E1BB04-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSHVVTIEEPQAKPQVSQTRFGGKSGAWGNVSASRTYDFLYDPLFIVSSEKDHNQANIQATVIRSKLRRVPRFRTMFSSLFHYPRYSVYWSKADPVPSFISRDWKRHEQRHREALQQLAAIDASFQMPKEVYEDPDVTGKNRYKYFERPFLPFYQQMPFNVVFASTRADPYTFPPPPTKYLPIPSKYTVGTQTDYRDAEVQTDPYSPEYVVCQDSIPELLTLATLTWGRGLPAGQAEVEMIERAREKRAWEDTLPPLSDTSQFEKRRRMMNAMERKEWAFREQEIEKLQEIRLEVLKELLKKRDENQNEVNMARLNAQWSKLQEAKEAKLAQIQRKHVSAIRKLMGKGKNIEGKLERRNIIKDYCDYASQVYGPLSRLGRFPDNNSEDFVVKNHYLNTYEGLVELESCLPDFVTQPRIKPPKPKVTTTKDGFLKRAARVDRELAEVHKALLEKKNKDFEAKKPMRFLQRKPVPQPRLPTPTLEMSSNEEEDIEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTSHALQEDDRLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRVLADMFDFLSKELVRLQEERRVHALAMLAERQRRMREAEESGRRQVEQRRLQEEDQIFKEVIKVHQSTVTSYLEDIILNTEENTAEEQARAEIEKMAEEINDIAYEMESRRTQLQSEEIVAELVYSFLIPEVQKDFVKEKVRNSQRKHILAAHQIIHRHTEDMLKTHFVEQRQTPDAELLEGETEKEQNT", "length": 764, "header": "tr|E1BB04-1|E1BB04_BOVIN Isoform 1 of Cilia- and flagella-associated protein 91 OS=Bos taurus OX=9913 GN=CFAP91 PE=1 SV=3 CANONICAL=E1BB04-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAM1-1", "url": "https://www.uniprot.org/uniprotkb/E1BB04/entry#A0AAA9SAM1-1", "sequence": { "sequence": "MFSLLFAFQFYSLTLEYTDITCISQTLTNDPLFIVSSEKDHNQANIQATVIRSKLRRVPRFRTMFSSLFHYPRYSVYWSKADPVPSFISRDWKRHEQRHREALQQLAAIDASFQMPKEVYEDPDVTGKNRYKYFERPFLPFYQQMPFNVVFASTRADPYTFPPPPTKYLPIPSKYTVGTQTDYRDAEVQTDPYSPEYVVCQDSIPELLTLATLTWGRGLPAGQAEVEMIERAREKRAWEDTLPPLSDTSQFEKRRRMMNAMERKEWAFREQEIEKLQEIRLEVLKELLKKRDENQNEVNMARLNAQWSKLQEAKEAKLAQIQRKHVSAIRKLMGKGKNIEGKLERRNIIKDYCDYASQVYGPLSRLGRFPDNNSEDFVVKNHYLNTYEGLVELESCLPDFVTQPRIKPPKPKVTTTKDGFLKRAARVDRELAEVHKALLEKKNKDFEAKKPMRFLQRKPVPQPRLPTPTLEMSSNEEEDIEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTSHALQEDDRLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRVLADMFDFLSKELVRLQEERRVHALAMLAERQRRMREAEESGRRQVEQRRLQEEDQIFKEVIKVHQSTVTSYLEDIILNTEENTAEEQARAEIEKMAEEINDIAYEMESRRTQLQSEEIVAELVYSFLIPEVQKDFVKEKVRNSQRKHILAAHQIIHRHTEDMLKTHFVEQRQTPDAELLEGETEKEQNT", "length": 752, "header": "tr|A0AAA9SAM1-1|E1BB04_BOVIN Computationally mapped isoform of Cilia- and flagella-associated protein 91 OS=Bos taurus OX=9913 GN=CFAP91 PE=1 SV=1 CANONICAL=E1BB04-1" }, "locus": { "chromosome": "1", "start_pos": 64545472, "end_pos": 64462322, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116756.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116756.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083138.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083138.1" } ] } }, { "isoform_ac": "A0AAA9SN22-1", "url": "https://www.uniprot.org/uniprotkb/E1BB04/entry#A0AAA9SN22-1", "sequence": { "sequence": "MSHVVTIEEPQAKPQVSQTRFGGKSGAWGNVSASRTYDFLYDPLFIVSSEKDHNQANIQATVIRSKLRRVPRFRTMFSSLFHYPRYSVYWSKADPVPSFISRDWKRHEQRHREALQQLAAIDASFQMPKEVYEDPDVTGKNRYKYFERPFLPFYQQMPFNVVFASTRADPYTFPPPPTKYLPIPSKYTVGTQTDYRDAEVQTDPYSPEYVVCQDSIPELLTLATLTWGRGLPAGQAEVEMIERAREKRAWEDTLPPLSDTSQFEKRRRMMNAMERKEWAFREQEIEKLQEIRLEVLKELLKKRDENQNEVNMARLNAQWSKLQEAKEAKLAQIQRKHVSAIRKLMGKGKNIEGKLERRNIIKDYCDYASQVYGPLSRLGRFPDNNSEDFVVKNHYLNTYEGLVELESCLPDFVTQPRIKPPKPKVTTTKDGFLKRAARVDRELAEVHKALLEKKNKDFEAKKPMRFLQRKPVPQPRLPTPTLEMSSNEEEDIEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTSHALQEDDRLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRVLADMFDFLSKELVRLQEERRVHALAMLAERQRRMREAEESGRRQVEQRRLQEEDQIFKEVIKVHQSTVTSYLEDIILNTEENTAEEQARAEIEKMAEEINDIAYEMESREELSAEAYPGSPSDHPQAHRGHAQDAFC", "length": 712, "header": "tr|A0AAA9SN22-1|E1BB04_BOVIN Computationally mapped isoform of Cilia- and flagella-associated protein 91 OS=Bos taurus OX=9913 GN=CFAP91 PE=1 SV=1 CANONICAL=E1BB04-1" }, "locus": { "chromosome": "1", "start_pos": 64545408, "end_pos": 64451499, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133458.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133458.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086716.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086716.1" } ] } }, { "isoform_ac": "A0AAA9T7P3-1", "url": "https://www.uniprot.org/uniprotkb/E1BB04/entry#A0AAA9T7P3-1", "sequence": { "sequence": "MSNSLGNSKLVILDPLFIVSSEKDHNQANIQATVIRSKLRRVPRFRTMFSSLFHYPRYSVYWSKADPVPSFISRDWKRHEQRHREALQQLAAIDASFQMPKEVYEDPDVTGKNRYKYFERPFLPFYQQMPFNVVFASTRADPYTFPPPPTKYLPIPSKYTVGTQTDYRDAEVQTDPYSPEYVVCQDSIPELLTLATLTWGRGLPAGQAEVEMIERAREKRAWEDTLPPLSDTSQFEKRRRMMNAMERKEWAFREQEIEKLQEIRLEVLKELLKKRDENQNEVNMARLNAQWSKLQEAKEAKLAQIQRKHVSAIRKLMGKGKNIEGKLERRNIIKDYCDYASQVYGPLSRLGRFPDNNSEDFVVKNHYLNTYEGLVELESCLPDFVTQPRIKPPKPKVTTTKDGFLKRAARVDRELAEVHKALLEKKNKDFEAKKPMRFLQRKPVPQPRLPTPTLEMSSNEEEDIEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTSHALQEDDRLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRVLADMFDFLSKELVRLQEERRVHALAMLAERQRRMREAEESGRRQVEQRRLQEEDQIFKEVIKVHQSTVTSYLEDIILNTEENTAEEQARAEIEKMAEEINDIAYEMESRRTQLQSEEIVAELVYSFLIPEVQKDFVKEKVRNSQRKHILAAHQIIHRHTEDMLKTHFVEQRQTPDAELLEGETEKEQNT", "length": 736, "header": "tr|A0AAA9T7P3-1|E1BB04_BOVIN Computationally mapped isoform of Cilia- and flagella-associated protein 91 OS=Bos taurus OX=9913 GN=CFAP91 PE=1 SV=1 CANONICAL=E1BB04-1" }, "locus": { "chromosome": "1", "start_pos": 64545472, "end_pos": 64451990, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127012.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127012.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092796.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092796.1" } ] } }, { "isoform_ac": "A0AAA9TTG9-1", "url": "https://www.uniprot.org/uniprotkb/E1BB04/entry#A0AAA9TTG9-1", "sequence": { "sequence": "MSHVVTIEEPQAKPQVSQTRFGGKSGAWGNVSASRTYDFLYDPLFIVSSEKDHNQANIQATVIRSKLRRVPRFRTMFSSLFHYPRYSVYWSKADPVPSFISRDWKRHEQRHREALQQLAAIDASFQMPKEVYEDPDVTGKNRYKYFERPFLPFYQQMPFNVVFASTRADPYTFPPPPTKYLPIPSKYTVGTQTDYRDAEVQTDPYSPEYVVCQDSIPELLTLATLTWGRGLPAGQAEVEMIERAREKRAWEDTLPPLSDTSQFEKRRRMMNAMERKEWAFREQEIEKLQEIRLEVLKELLKKRDENQNEVNMARLNAQWSKLQEAKEAKLAQIQRKHVSAIRKLMGKGKNIEGKLERRNIIKDYCDYASQVYGPLSRLGRFPDNNSEDFVVKNHYLNTYEGLVELESCLPDFVTQPRIKPPKPKVTTTKDGFLKRAARVDRELAEVHKALLEKKNKDFEAKKPMRFLQRKPVPQPRLPTPTLEMSSNEEEDIEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTSHALQEDDRLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRVLADMFDFLSKELVRLQEERRVHALAMLAERQRRMREAEESGRRQVEQRRLQEEDQIFKEVIKVHQSTVTSYLEDIILNTEENTAEEQARAEIEKMAEEINDIAYEMESRRTQLQSEEIVAELVYSFLIPEVQKDFVKEKG", "length": 715, "header": "tr|A0AAA9TTG9-1|E1BB04_BOVIN Computationally mapped isoform of Cilia- and flagella-associated protein 91 OS=Bos taurus OX=9913 GN=CFAP91 PE=1 SV=1 CANONICAL=E1BB04-1" }, "locus": { "chromosome": "1", "start_pos": 64524849, "end_pos": 64451499, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094336.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094336.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101652.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101652.1" } ] } }, { "isoform_ac": "E1BB04-1", "url": "https://www.uniprot.org/uniprotkb/E1BB04/entry#E1BB04-1", "sequence": { "sequence": "MSHVVTIEEPQAKPQVSQTRFGGKSGAWGNVSASRTYDFLYDPLFIVSSEKDHNQANIQATVIRSKLRRVPRFRTMFSSLFHYPRYSVYWSKADPVPSFISRDWKRHEQRHREALQQLAAIDASFQMPKEVYEDPDVTGKNRYKYFERPFLPFYQQMPFNVVFASTRADPYTFPPPPTKYLPIPSKYTVGTQTDYRDAEVQTDPYSPEYVVCQDSIPELLTLATLTWGRGLPAGQAEVEMIERAREKRAWEDTLPPLSDTSQFEKRRRMMNAMERKEWAFREQEIEKLQEIRLEVLKELLKKRDENQNEVNMARLNAQWSKLQEAKEAKLAQIQRKHVSAIRKLMGKGKNIEGKLERRNIIKDYCDYASQVYGPLSRLGRFPDNNSEDFVVKNHYLNTYEGLVELESCLPDFVTQPRIKPPKPKVTTTKDGFLKRAARVDRELAEVHKALLEKKNKDFEAKKPMRFLQRKPVPQPRLPTPTLEMSSNEEEDIEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTSHALQEDDRLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRVLADMFDFLSKELVRLQEERRVHALAMLAERQRRMREAEESGRRQVEQRRLQEEDQIFKEVIKVHQSTVTSYLEDIILNTEENTAEEQARAEIEKMAEEINDIAYEMESRRTQLQSEEIVAELVYSFLIPEVQKDFVKEKVRNSQRKHILAAHQIIHRHTEDMLKTHFVEQRQTPDAELLEGETEKEQNT", "length": 764, "header": "tr|E1BB04-1|E1BB04_BOVIN Isoform 1 of Cilia- and flagella-associated protein 91 OS=Bos taurus OX=9913 GN=CFAP91 PE=1 SV=3 CANONICAL=E1BB04-1" }, "locus": { "chromosome": "1", "start_pos": 64545472, "end_pos": 64451499, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001703.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001703.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001703.6", "url": "https://www.ensembl.org/id/ENSBTAP00000001703.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structural diversity of axonemes across mammalian motile cilia.", "journal": "Nature", "date": "2025", "authors": "Leung Miguel Ricardo, Sun Chen, Zeng Jianwei, Anderson Jacob R, Niu Qingwei, Huang Wei, Noteborn Willem E M, Brown Alan, Zeev-Ben-Mordehai Tzviya, Zhang Rui", "evidence": [ { "database": "UniProtKB", "id": "E1BB04", "url": "https://www.uniprot.org/uniprotkb/E1BB04" } ], "reference": [ { "type": "PubMed", "id": "39743588", "url": "https://glygen.org/publication/PubMed/39743588" } ] } ], "pathway": [ { "id": "bta:100300968", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100300968", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1Q5Z7-1", "protein_name": "Cilia- and flagella-associated protein 91", "gene_name": "cfap91", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSVSVTRTFDKKNEGNKGFRQQRTYDYLYDPVYTLSADVDHGRENIRAQASLDRMRRVPEFNSMISDLPHHPQYSLRLEATDPVPGFIDRRWRGYAEQRRQALQQLTGIVSGAVTHAPNPANVTGVDRWKFFKRPLIPFAQQIPPDVVFALPKSDLLSSDGDDKRSPTPFQRSVAVQTDYRESETQTDPYSPSYLLRPGTTSPELLTLATLTWGHGLPAGLAEVEMIKRARIKRAWEATLPPLNDLSQLDKRRRMMEEMERKEWAFREQEIEKLQETRLTLLLQLLRQREEEQEEVKMERLDASFSQRQNEKEARLKKIRSDYIIAMRKLLAKRKNVEGNLEKRDIIKDYSDYGSQMYAPLARTGQTPDRNSNRSTVKSHFLSTYQGLLELEASLSPSVTLPQIKVPKPKVTKGFISRSARRDLELMKTHQALKEEKVCRVEKKPLRFLFKKEKPVPRPPTPTVEKPPEGDEERELAIIFLQKLLRGRSTQNQMFEEKERWLELIQELRTTHALQKEEQDKKEVEKQVTLALQRQRDFQIDREAQIESFTAALSGGVIVDMLDFLSKELVRLQEERRIHAFTLLAERDRRIREAEESGRRQIEERRRREEDEIFKQVVRVHQDTVDMYLEDVILTSINQTADAQAREEIHRKAEELNNITYAMEETMNSQQSEEIVAELVYRFLIPEVQKMDFRERVRHSQRRHLQAARLIISPGSTVPTEPQSPSYRASSAILNHILSQVEEVVPGNLTSRDPEPTQNTLTSHTKTEDTHNTDGKKADSAQGQL", "length": 785 }, "evidence": [ { "id": "E1BB04", "url": "https://omabrowser.org/oma/group/E1BB04/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1SPB5-1", "protein_name": "Cilia- and flagella-associated protein 91", "gene_name": "CFAP91", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSHVVTITEPQAKPQMSQTQCRGKSGTWGNVSASRTYDFLYDPLFIVSSEKDHNRANNQATLIRSKLRRVPRFRTMFSSLFHYPNHSVYWSKADPVPSFISREWKGLEERHREAFRHLAETDTSFLMPKEVYEDPDVTGKNRYKYFERPFLPFHQRVPFSVVYASTRAEPYTFPSPSTKYSPIPSKYTVSTQTDYRDGEAQTDPYSPEYVICQDSIPELLTLATLTWGRGLPAGQAEVEMIERAREKRAWEATLPPLSDTSQFEKRRRMMNAMERKEWAFREQEIEKLQEIRLEVLKELLKKRDENQNEVNMARLNAQWSKLQKVKEAKLAQIQHTHVSAIRKLMGKGKNIEGKLERRNIIKDYSDYASQVYGPLSRLGRFPDNNSEDFVVKNHYLNTYEGLVELESCLPEFVTQPRIRAPKPKVTTTKAGFLKRAARRDHELAEVHKALLDKKNKVLKTKKPMRFLQRKPVPQPRLPTPTLEMSSNEEEDIEMAVIYLQKLLRGRVIQNMMFEGKEKRLELIQELRTSQALQEDDRLVKKAEKQVTLALQRQRNLHEHKVSLFENHLAGLEGRVLADMFDFLSKELVRLQEERRVHALAMLAERQRRMREAEESGRRQVEQRRLQEEDQIFKEVIKVHQSTVTSYLEDIILNTEENTAEEQARAEIEKMAEEINDIAYEMESRRTQLQSEEIVAELVYSFLIPEVQKDFVKEKVRNAQRKHILAAHEIIHRHTEAMLEKNFFAQHQESDSKLFEGESENEQNS", "length": 764 }, "evidence": [ { "id": "E1BB04", "url": "https://omabrowser.org/oma/group/E1BB04/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q7Z4T9-7", "protein_name": "Cilia- and flagella-associated protein 91", "gene_name": "CFAP91", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSHAVTIEEPQAQPQVSQTRYRERSRAGSHISSNRAYDFLYDPLFIVSSEKDHTQANIQATLIRSRLRKVPRFKTMFSNLIHYPRYSLYWSKSDPVPPFISREWKGHKEKHREALRQLTTTDASFQMPKEVYEDPEVTGKNRYKYFERPFLPFFQQMPFNVVYAVSKAEPYTFPPTSTKHLSIPSKSTVGTQTDYRDADVQTDPYSAEYVVCQDSIPELLTLATLTWGRGLPAGQAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLLEKETQNENNS", "length": 767 }, "evidence": [ { "id": "E1BB04", "url": "https://omabrowser.org/oma/group/E1BB04/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BRC6-2", "protein_name": "Cilia- and flagella-associated protein 91", "gene_name": "Cfap91", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSQTVTIQEPRPNDQRIPYQCREVRRAKGGFANRTYDYLYDPLFIVSSERDHAQANIQATLIRSRLKKVPNFRSMFSNLFHHPRYSMYWSKTDPVPLHVTREWRGQEAKHKEVLRLQAAMDTSFQMPKEKDEDPDVSGKNRYKFFDRPFLPFLQQMPLNVVLSPVKTQPLLLTPESSKYAIIPTKSTVATQTDYRDADVQTDPYSPEYVVCQDTIPELLTLANLTWGRGLPAGQAEVEIIERAREKRAWEATLPPLNDSVQAEKRRKMMNAMERKEWAFREGEIEKLQELRLEVLKQLLKRREEDQNELNMRHLNDQWYKLQEAKEAKVAQIRHKHVSDIRKLMGKGKNIEGKLQRRDIISDYSNFASQVYGPLSRLGRFPDNNSEDFVVRNHYLNTYEGLVELESSLPDFVTQPRIKPPKPQIITTKAGFLKRTARMDYELAEVHKALVDKKNKGLEGTKSLRFLQKNPISQARLPTPSLEMTSYEEGEIEMAVIYLQKLLRGRVVQNMMFEGKEKRLELILELRTSHALQEDDKLVKKAEKQVTLALQRQRNLHEDKLSVIENHLGDLEGRVLADMFDFLSKELVRLQEERRIHAFAMLAERQRRMREAEESGRRQVEQKRLQQEDMIFKEVIKVHQSTVTSYLEDIILNTEERTAEEQARKEIEKIAEEINNIAYEMENRRTYLQSEEIVAELVYSFLIPEVQKDFVKEKVRNAQRKHILAAHEIIHSNTETMLEEQVYKELQSEDFELEEEAESLDSEVPTVSVSKTSTIKPTQDEGEG", "length": 783 }, "evidence": [ { "id": "E1BB04", "url": "https://omabrowser.org/oma/group/E1BB04/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "E1BB04", "url": "https://www.uniprot.org/uniprotkb/E1BB04" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "axonemal central apparatus assembly", "id": "GO:1904158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904158", "evidence": [ { "database": "UniProtKB", "id": "E1BB04", "url": "https://www.uniprot.org/uniprotkb/E1BB04" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "E1BB04", "url": "https://www.uniprot.org/uniprotkb/E1BB04" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 30, "end_pos": 32, "annotation": "n_glycosylation_sequon" }, { "start_pos": 384, "end_pos": 386, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BB04-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 764, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BB04-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BB04" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BB04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB04" }, { "id": "PF14738", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14738" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CFAP91", "eco_id": "ECO_0000259", "start_pos": 191, "end_pos": 343, "start_aa": "Thr", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 30, "end_pos": 32 }, { "start_pos": 384, "end_pos": 386 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": 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{ "name": "ELSPBP1", "type": "recommended", "evidence": [ { "id": "E1B9P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9P4" } ] }, { "name": "ELSPBP1", "type": "synonym", "evidence": [ { "id": "NP_001179487", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179487" } ] } ], "protein_names": [ { "name": "Epididymal sperm-binding protein 1", "type": "recommended", "evidence": [ { "id": "E1B9P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9P4/entry#names_and_taxonomy" } ] }, { "name": "Epididymal secretory protein 12", "type": "synonym", "evidence": [ { "id": "E1B9P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9P4/entry#names_and_taxonomy" } ] }, { "name": "epididymal sperm-binding protein 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001179487", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179487" } ] } ], "function": [ { "annotation": "Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity.", "evidence": [ { "database": "UniProtKB", "id": "E1B9P4", "url": "https://www.uniprot.org/uniprotkb/E1B9P4#function" }, { "database": "UniProtKB", "id": "ARBA00053061", "url": "https://www.uniprot.org/uniprotkb/ARBA00053061#function" }, { "database": "UniProtKB", "id": "A0AAA9SBR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBR6#function" }, { "database": "UniProtKB", "id": "A0AAA9SIA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA0#function" } ] }, { "annotation": "ELSPBP1 could be a tag for the recognition of dead spermatozoa during epididymal transit. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001179487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179487" }, { "database": "PubMed", "id": "22875906", "url": "https://glygen.org/publication/PubMed/22875906" } ] }, { "annotation": "The presence of BSP1 over the acrosomal region characterises spermatozoa sensitive to cryopreservation and ELSPBP1 characterises spermatozoa that are already dead at ejaculation.", "evidence": [ { "database": "RefSeq", "id": "NP_001179487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179487" }, { "database": "PubMed", "id": "22457431", "url": "https://glygen.org/publication/PubMed/22457431" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9P4", "url": "https://www.uniprot.org/uniprotkb/E1B9P4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ELSPBP1", "url": "https://www.uniprot.org/uniprotkb/E1B9P4", "locus": { "chromosome": "18", "start_pos": 54846635, "end_pos": 54816488, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016113", "url": "https://www.ensembl.org/id/ENSBTAG00000016113" } ] } } ], "crossref": [ { "id": "E1B9P4", "url": "https://alphafold.ebi.ac.uk/entry/E1B9P4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016113", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016113", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00062", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00062", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "522297", "url": "https://www.ncbi.nlm.nih.gov/gene/522297", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000562", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000562", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522297", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522297", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IFRGKSH", "url": "https://omabrowser.org/oma/group/IFRGKSH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B9P4", "url": "https://www.orthodb.org/?gene=E1B9P4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22918", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22918", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22918:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22918:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00040", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00040", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179487", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SBR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBR6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIA0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIA0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIA0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9P4", "url": "https://www.uniprot.org/uniprotkb/E1B9P4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9P4-1", "url": "https://www.uniprot.org/uniprotkb/E1B9P4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNGWPSYLLGWMAFLLYSYGTTGNKKDSCIFPFTYKGSTYFSCTRANSLSPWCSTRAIYDGRWKHCLTEDYPRCVFPFIYRGKPHNGCITDGSLFGRQWCSVTSSFDEKQQWKYCETNEYGGNSFSKPCIFPATYRNHVVSECLEDENNKLWCPTTENMDKDGKWSLCADTRISSLVPGFPCHFPFNYKNKNYFNCTNKGSKENLLWCATSYNYDRDHTWVYC", "length": 223, "header": "tr|E1B9P4-1|E1B9P4_BOVIN Isoform 1 of Epididymal sperm-binding protein 1 OS=Bos taurus OX=9913 GN=ELSPBP1 PE=3 SV=1 CANONICAL=E1B9P4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBR6-1", "url": "https://www.uniprot.org/uniprotkb/E1B9P4/entry#A0AAA9SBR6-1", "sequence": { "sequence": "MDGPVTCWGGWPSSSTPMEQLEGIFLIQGSNPASCIAGRSLPSEPPGESAHDKKDSCIFPFTYKGSTYFSCTRANSLSPWCSTRAIYDGRWKHCLTEDYPRCVFPFIYRGKPHNGCITDGSLFGRQWCSVTSSFDEKQQWKYCETNEYGGNSFSKPCIFPATYRNHVVSECLEDENNKLWCPTTENMDKDGKWSLCADTRISSLVPGFPCHFPFNYKNKNYFNCTNKGSKENLLWCATSYNYDRDHTWVYC", "length": 251, "header": "tr|A0AAA9SBR6-1|E1B9P4_BOVIN Computationally mapped isoform of Epididymal sperm-binding protein 1 OS=Bos taurus OX=9913 GN=ELSPBP1 PE=3 SV=1 CANONICAL=E1B9P4-1" }, "locus": { "chromosome": "18", "start_pos": 54846625, "end_pos": 54837600, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094528.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094528.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082837.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082837.1" } ] } }, { "isoform_ac": "A0AAA9SIA0-1", "url": "https://www.uniprot.org/uniprotkb/E1B9P4/entry#A0AAA9SIA0-1", "sequence": { "sequence": "MQASFTDSAQGIFLIQGSNPASCIAGRSLPSEPPGESAHDKKDSCIFPFTYKGSTYFSCTRANSLSPWCSTRAIYDGRWKHCLTEDYPRCVFPFIYRGKPHNGCITDGSLFGRQWCSVTSSFDEKQQWKYCETNEYGGNSFSKPCIFPATYRNHVVSECLEDENNKLWCPTTENMDKDGKWSLCADTRISSLVPGFPCHFPFNYKNKNYFNCTNKGSKENLLWCATSYNYDRDHTWVYC", "length": 239, "header": "tr|A0AAA9SIA0-1|E1B9P4_BOVIN Computationally mapped isoform of Epididymal sperm-binding protein 1 OS=Bos taurus OX=9913 GN=ELSPBP1 PE=3 SV=1 CANONICAL=E1B9P4-1" }, "locus": { "chromosome": "18", "start_pos": 54846625, "end_pos": 54837927, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133215.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133215.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083473.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083473.1" } ] } }, { "isoform_ac": "E1B9P4-1", "url": "https://www.uniprot.org/uniprotkb/E1B9P4/entry#E1B9P4-1", "sequence": { "sequence": "MNGWPSYLLGWMAFLLYSYGTTGNKKDSCIFPFTYKGSTYFSCTRANSLSPWCSTRAIYDGRWKHCLTEDYPRCVFPFIYRGKPHNGCITDGSLFGRQWCSVTSSFDEKQQWKYCETNEYGGNSFSKPCIFPATYRNHVVSECLEDENNKLWCPTTENMDKDGKWSLCADTRISSLVPGFPCHFPFNYKNKNYFNCTNKGSKENLLWCATSYNYDRDHTWVYC", "length": 223, "header": "tr|E1B9P4-1|E1B9P4_BOVIN Isoform 1 of Epididymal sperm-binding protein 1 OS=Bos taurus OX=9913 GN=ELSPBP1 PE=3 SV=1 CANONICAL=E1B9P4-1" }, "locus": { "chromosome": "18", "start_pos": 54846625, "end_pos": 54837596, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021448.5", "url": "https://www.ensembl.org/id/ENSBTAT00000021448.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021448.3", "url": "https://www.ensembl.org/id/ENSBTAP00000021448.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Binder of sperm 1 and epididymal sperm binding protein 1 are associated with different bull sperm subpopulations.", "journal": "Reproduction (Cambridge, England)", "date": "2012-06", "authors": "D'Amours Olivier, Bordeleau Louis-Jean, Frenette Gilles, Blondin Patrick, Leclerc Pierre, Sullivan Robert", "evidence": [ { "database": "RefSeq", "id": "NP_001179487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179487" } ], "reference": [ { "type": "PubMed", "id": "22457431", "url": "https://glygen.org/publication/PubMed/22457431" } ] }, { "title": "Epididymosomes transfer epididymal sperm binding protein 1 (ELSPBP1) to dead spermatozoa during epididymal transit in bovine.", "journal": "Biology of reproduction", "date": "2012-10", "authors": "D'Amours Olivier, Frenette Gilles, Bordeleau Louis-Jean, Allard Nancy, Leclerc Pierre, Blondin Patrick, Sullivan Robert", "evidence": [ { "database": "RefSeq", "id": "NP_001179487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179487" } ], "reference": [ { "type": "PubMed", "id": "22875906", "url": "https://glygen.org/publication/PubMed/22875906" } ] } ], "pathway": [ { "id": "bta:522297", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522297", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RLA2-1", "protein_name": "Epididymal sperm-binding protein 1", "gene_name": "ELSPBP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNRWSSYLLGCTAFILYSYETSGDTKDSCVFPFNYKGFTYFSCTRTNSLSPWCATRAVYDGQWKYCLIEDYPRCVFPFIYRGRSHRNCIVEGSFFGKLWCSVTSSFDEKQQWKYCEINEYGGNSFSKPCIFPSKYRNHIISECLEDESNKLWCPTTENMDMDGKWSLCADTRISSLVPGFPCHFPFNYKNKNYFNCTTKGSKENLLWCATSYNYDQDHTWVYC", "length": 223 }, "evidence": [ { "id": "E1B9P4", "url": "https://omabrowser.org/oma/group/E1B9P4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q96BH3-1", "protein_name": "Epididymal sperm-binding protein 1", "gene_name": "ELSPBP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"Protein Classification" ] }, { "id": "PF02902", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02902", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3065679", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3065679", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SDF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDF4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVH0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVH0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVH0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAI5", "url": "https://www.uniprot.org/uniprotkb/E1BAI5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAI5-1", "url": "https://www.uniprot.org/uniprotkb/E1BAI5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSGRAGGGDVRSGGPRGPPVALGTLYLWALGSRHKSATELWRRWPRQRRRQRRRQLWGLRLGVCRPPLLLGPGMYKWLIRILGTIFRFCDRPVPSARALLKRRRSNSTLFSTVDADEIPAKRPRLDCFIHQVKTSLYNAASLFGFPFQLTTKPMVTSACNGTRNVVPSGEVFSNSSSSELNDSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSLGFALSSEGYTRRPGGRRHNKGNPESSLMWRPQEQVVTEMISEEGGKGLRRPHCTVEEGVQKEEREKYQRLLERLKEGGHGNCVSPITSTHQSSQRSQMDTLKTKGWGEEQSHGVKTTQFVPKQYRVVETRGPLCSVRSEKRCSKGKISDTEKTVGIRLENECRRGLQLEPDLSEEVSARLRLGSGSNGLLRRKMSILETKEKNCSNKERDKRTDDLLELTEDMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLRNYHWLNDEVINFYMNLLVERNKRQGYPALYAFSTFFYPKLKSGGYQAVKRWTKGVSLFEQELILVPIHRKVHWSLVAIDLRKRCLKYLDSMGQKGHRICEILLQYLQDESKTKRNIDLNLLEWTHYSMKPQEIPQQLNGSDCGMFTCKYADYISRDKPITFTQHQMPLFRKKMVWEILHQQLL", "length": 663, "header": "tr|E1BAI5-1|E1BAI5_BOVIN Isoform 1 of SUMO specific peptidase 2 OS=Bos taurus OX=9913 GN=SENP2 PE=3 SV=2 CANONICAL=E1BAI5-1" }, "isoforms": [ { 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"MLSGRAGGGDVRSGGPRGPPVALGTLYLWALGSRHKSATELWRRWPRQRRRQRRRQLWGLRLGVCRPPLLLGPGMYKWLIRILGTIFRFCDRPVPSARALLKRRRSNSTLFSTVDADEIPAKRPRLDCFIHQVKTSLYNAASLFGFPFQLTTKPMVTSACNGTRNVVPSGEVFSNSSSSELNDSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSLGFALSSEGYTRRPGGRRHNKGNPESSLMWRPQEQVVTEMISEEGGKGLRRPHCTVEEGVQKEEREKYQRLLERLKEGGHGNCVSPITSTHQRCSKGKISDTEKTVGIRLENECRRGLQLEPDLSEEVSARLRLGSGSNGLLRRKMSILETKEKNCSNKERDKRTDDLLELTEDMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLRNYHWLNDEVINFYMNLLVERNKRQGYPALYAFSTFFYPKLKSGGYQAVKRWTKGVSLFEQELILVPIHRKVHWSLVAIDLRKRCLKYLDSMGQKGHRICEILLQYLQDESKTKRNIDLNLLEWTHYSMKPQEIPQQLNGSDCGMFTCKYADYISRDKPITFTQHQMPLFRKKMVWEILHQQLL", "length": 614, "header": "tr|A0AAA9TVH0-1|E1BAI5_BOVIN Computationally mapped isoform of SUMO specific peptidase 2 OS=Bos taurus OX=9913 GN=SENP2 PE=3 SV=1 CANONICAL=E1BAI5-1" }, "locus": { "chromosome": "1", "start_pos": 81621328, "end_pos": 81587522, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132330.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132330.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101411.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101411.1" } ] } }, { "isoform_ac": "E1BAI5-1", "url": "https://www.uniprot.org/uniprotkb/E1BAI5/entry#E1BAI5-1", "sequence": { "sequence": "MLSGRAGGGDVRSGGPRGPPVALGTLYLWALGSRHKSATELWRRWPRQRRRQRRRQLWGLRLGVCRPPLLLGPGMYKWLIRILGTIFRFCDRPVPSARALLKRRRSNSTLFSTVDADEIPAKRPRLDCFIHQVKTSLYNAASLFGFPFQLTTKPMVTSACNGTRNVVPSGEVFSNSSSSELNDSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSLGFALSSEGYTRRPGGRRHNKGNPESSLMWRPQEQVVTEMISEEGGKGLRRPHCTVEEGVQKEEREKYQRLLERLKEGGHGNCVSPITSTHQSSQRSQMDTLKTKGWGEEQSHGVKTTQFVPKQYRVVETRGPLCSVRSEKRCSKGKISDTEKTVGIRLENECRRGLQLEPDLSEEVSARLRLGSGSNGLLRRKMSILETKEKNCSNKERDKRTDDLLELTEDMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLRNYHWLNDEVINFYMNLLVERNKRQGYPALYAFSTFFYPKLKSGGYQAVKRWTKGVSLFEQELILVPIHRKVHWSLVAIDLRKRCLKYLDSMGQKGHRICEILLQYLQDESKTKRNIDLNLLEWTHYSMKPQEIPQQLNGSDCGMFTCKYADYISRDKPITFTQHQMPLFRKKMVWEILHQQLL", "length": 663, "header": "tr|E1BAI5-1|E1BAI5_BOVIN Isoform 1 of SUMO specific peptidase 2 OS=Bos taurus OX=9913 GN=SENP2 PE=3 SV=2 CANONICAL=E1BAI5-1" }, "locus": { "chromosome": "1", "start_pos": 81621328, "end_pos": 81587522, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002296.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002296.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002296.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002296.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-3065679", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3065679", "resource": "Reactome", "description": "SUMO is proteolytically processed" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1BAI5", "url": "https://www.uniprot.org/uniprotkb/E1BAI5" } ], "pmid": "" }, { "name": "regulation of primary metabolic process", "id": "GO:0080090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080090", "evidence": [ { "database": "UniProtKB", "id": "E1BAI5", "url": "https://www.uniprot.org/uniprotkb/E1BAI5" } ], "pmid": "" }, { "name": "regulation of macromolecule metabolic process", "id": "GO:0060255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060255", "evidence": [ { "database": "UniProtKB", "id": "E1BAI5", "url": "https://www.uniprot.org/uniprotkb/E1BAI5" } ], "pmid": "" }, { "name": "positive regulation of protein ubiquitination", "id": "GO:0031398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031398", "evidence": [ { "database": "UniProtKB", "id": "E1BAI5", "url": "https://www.uniprot.org/uniprotkb/E1BAI5" } ], "pmid": "" }, { "name": "fat cell differentiation", "id": "GO:0045444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045444", "evidence": [ { "database": "UniProtKB", "id": "E1BAI5", "url": "https://www.uniprot.org/uniprotkb/E1BAI5" } ], "pmid": "" }, { "name": "negative regulation of protein ubiquitination", "id": "GO:0031397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031397", "evidence": [ { "database": "UniProtKB", "id": "E1BAI5", "url": "https://www.uniprot.org/uniprotkb/E1BAI5" } ], "pmid": "" }, { "name": "protein destabilization", "id": "GO:0031648", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031648", "evidence": [ { "database": "UniProtKB", "id": "E1BAI5", "url": "https://www.uniprot.org/uniprotkb/E1BAI5" } ], "pmid": "" }, { "name": "protein desumoylation", "id": "GO:0016926", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016926", "evidence": [ { "database": "UniProtKB", "id": "E1BAI5", "url": "https://www.uniprot.org/uniprotkb/E1BAI5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "cysteine-type peptidase activity", "id": "GO:0008234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008234", "evidence": [ { "database": "UniProtKB", "id": "E1BAI5", "url": "https://www.uniprot.org/uniprotkb/E1BAI5" } ], "pmid": "" }, { "name": "deSUMOylase activity", "id": "GO:0016929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016929", "evidence": [ { "database": "UniProtKB", "id": "E1BAI5", "url": "https://www.uniprot.org/uniprotkb/E1BAI5" } ], "pmid": "" }, { "name": "SUMO-specific endopeptidase activity", "id": "GO:0070139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070139", "evidence": [ { "database": "UniProtKB", "id": "E1BAI5", "url": "https://www.uniprot.org/uniprotkb/E1BAI5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BAI5", "url": "https://www.uniprot.org/uniprotkb/E1BAI5" } ], "pmid": "" }, { "name": "nuclear pore", "id": "GO:0005643", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005643", "evidence": [ { "database": "UniProtKB", "id": "E1BAI5", "url": "https://www.uniprot.org/uniprotkb/E1BAI5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BAI5", "url": "https://www.uniprot.org/uniprotkb/E1BAI5" } ], "pmid": "" }, { "name": "PML body", "id": "GO:0016605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016605", "evidence": [ { "database": "UniProtKB", "id": "E1BAI5", "url": "https://www.uniprot.org/uniprotkb/E1BAI5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 182, "end_pos": 184, 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"monoisotopic_mass": 27241.0 }, "refseq": { "ac": "XP_003586472", "name": "homeobox protein BarH-like 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586472" }, "gene_names": [ { "name": "BARX1", "type": "recommended", "evidence": [ { "id": "E1B7H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H9" } ] }, { "name": "BARX1", "type": "synonym", "evidence": [ { "id": "XP_003586472", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586472" } ] } ], "protein_names": [ { "name": "BARX homeobox 1", "type": "synonym", "evidence": [ { "id": "E1B7H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H9/entry#names_and_taxonomy" } ] }, { "name": "homeobox protein BarH-like 1", "type": "synonym", "evidence": [ { "id": "XP_003586472", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586472" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": 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"XP_003586472", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586472", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SDJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7H9", "url": "https://www.uniprot.org/uniprotkb/E1B7H9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7H9-1", "url": "https://www.uniprot.org/uniprotkb/E1B7H9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQRPGEPGAARFGPPEGCADHRPHRYRSFMIEEILTEPPGPKGAAPAAAAAAAGELLKFGVQALLAARPFHSHLAVLKAEQAAVFKFPLAPLGCSGLGSALLAAGPGLPGAAGAPHLPLELQLRGKLEAPGAGEPGTKAKKGRRSRTVFTELQLMGLEKRFEKQKYLSTPDRIDLAESLGLSQLQVKTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPTSEQLTEQERAKEAEKTVEAPGEASDRSHED", "length": 254, "header": "tr|E1B7H9-1|E1B7H9_BOVIN Isoform 1 of BARX homeobox 1 OS=Bos taurus OX=9913 GN=BARX1 PE=3 SV=3 CANONICAL=E1B7H9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDJ8-1", "url": "https://www.uniprot.org/uniprotkb/E1B7H9/entry#A0AAA9SDJ8-1", "sequence": { "sequence": "MLQFPSKRGPAALSVLKAEQAAVFKFPLAPLGCSGLGSALLAAGPGLPGAAGAPHLPLELQLRGKLEAPGAGEPGTKAKKGRRSRTVFTELQLMGLEKRFEKQKYLSTPDRIDLAESLGLSQLQVKTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPTSEQLTEQERAKEAEKTVEAPGEASDRSHED", "length": 193, "header": "tr|A0AAA9SDJ8-1|E1B7H9_BOVIN Computationally mapped isoform of BARX homeobox 1 OS=Bos taurus OX=9913 GN=BARX1 PE=3 SV=1 CANONICAL=E1B7H9-1" }, "locus": { "chromosome": "8", "start_pos": 85258525, "end_pos": 85252525, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119458.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119458.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081636.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081636.1" } ] } }, { "isoform_ac": "E1B7H9-1", "url": "https://www.uniprot.org/uniprotkb/E1B7H9/entry#E1B7H9-1", "sequence": { "sequence": "MQRPGEPGAARFGPPEGCADHRPHRYRSFMIEEILTEPPGPKGAAPAAAAAAAGELLKFGVQALLAARPFHSHLAVLKAEQAAVFKFPLAPLGCSGLGSALLAAGPGLPGAAGAPHLPLELQLRGKLEAPGAGEPGTKAKKGRRSRTVFTELQLMGLEKRFEKQKYLSTPDRIDLAESLGLSQLQVKTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPTSEQLTEQERAKEAEKTVEAPGEASDRSHED", "length": 254, "header": "tr|E1B7H9-1|E1B7H9_BOVIN Isoform 1 of BARX homeobox 1 OS=Bos taurus OX=9913 GN=BARX1 PE=3 SV=3 CANONICAL=E1B7H9-1" }, "locus": { "chromosome": "8", "start_pos": 85255518, "end_pos": 85252525, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005865.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005865.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005865.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005865.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539422", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539422", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1A521-1", "protein_name": "BARX homeobox 1", "gene_name": "BARX1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQHPLELGAAHYFPAEAFPDHRSHRYRSFMIEEILTDPPDAKGAAPPGELLKFGVQALLSARPYHSHLAVLKAEPAAVFKFPLAPLGCSGLGSALLAAGSGLQGGSASPHLPLELHLRGKLEPGGPETGSKAKKGRRSRTVFTELQLMGLEKRFEKQKYLSTPDRIDLAESLGLSQLQVKTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPSSEQLSEQERARDAEKPPESLGSPAEVSQEE", "length": 247 }, "evidence": [ { "id": "E1B7H9", "url": "https://omabrowser.org/oma/group/E1B7H9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZA67-1", "protein_name": "BARX homeobox 1", "gene_name": "Barx1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQRPGEPGSARFGPPEGCADHRPHRYRSFMIEEILTEPPGPKGAAPAAAAAAAGELLKFGVQALLAARPFHSHLAVLKAEQAAVFKFPLAPLGCSGLGSALLAAGPGMPGTAGTSHLPLELQLRGKLEAAGSGEPGTKAKKGRRSRTVFTELQLMGLEKRFEKQKYLSTPDRIDLAESLGLSQLQVKTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPTSEQLTEQERAKEAEKPAETPGEPSDRSCED", "length": 254 }, "evidence": [ { "id": "E1B7H9", "url": "https://omabrowser.org/oma/group/E1B7H9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SUC6-1", "protein_name": "BARX homeobox 1", "gene_name": "BARX1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQRPGEPGAARFGPPEGCADHRPHRYRSFMIEEILTEPPGPKGAAPAAAAAAAGELLKFGVQALLAARPFHSHLAVLKAEQAAVFKFPLAPLGCSGLGSALLAAGPGLPGAAGAPHLPLELQLRGKLESSGAGEPGTKAKKGRRSRTVFTELQLMGLEKRFEKQKYLSTPDRIDLAESLGLSQLQVKTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPTSEQLTEQERAKEAEKPAEALGEAGDRSHED", "length": 254 }, "evidence": [ { "id": "E1B7H9", "url": "https://omabrowser.org/oma/group/E1B7H9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9ER42-1", "protein_name": "Homeobox protein BarH-like 1", "gene_name": "Barx1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQRPGEPGAARFGPPEGCADHRPHRYRSFMIEEILTEPPGPKGAAPAAAAAAAGELLKFGVQALLAARPFHSHLAVLKAEQAAVFKFPLAPLGCSGLGSALLAAGPGMPGPAGASHLPLELQLRGKLEAAGSGEPGAKAKKGRRSRTVFTELQLMGLEKRFEKQKYLSTPDRIDLAESLGLSQLQVKTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPTSEQLTEQERAKETEKPAETPGEPSDRNCED", "length": 254 }, "evidence": [ { "id": "E1B7H9", "url": "https://omabrowser.org/oma/group/E1B7H9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HBU1-1", "protein_name": "Homeobox protein BarH-like 1", "gene_name": "BARX1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQRPGEPGAARFGPPEGCADHRPHRYRSFMIEEILTEPPGPKGAAPAAAAAAAGELLKFGVQALLAARPFHSHLAVLKAEQAAVFKFPLAPLGCSGLSSALLAAGPGLPGAAGAPHLPLELQLRGKLEAAGPGEPGTKAKKGRRSRTVFTELQLMGLEKRFEKQKYLSTPDRIDLAESLGLSQLQVKTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPTSEQLTEQERAKDAEKPAEVPGEPSDRSRED", "length": 254 }, "evidence": [ { "id": "E1B7H9", "url": "https://omabrowser.org/oma/group/E1B7H9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1B7H9", "url": "https://www.uniprot.org/uniprotkb/E1B7H9" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1B7H9", "url": "https://www.uniprot.org/uniprotkb/E1B7H9" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "E1B7H9", "url": "https://www.uniprot.org/uniprotkb/E1B7H9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B7H9", "url": "https://www.uniprot.org/uniprotkb/E1B7H9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1B7H9", "url": "https://www.uniprot.org/uniprotkb/E1B7H9" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1B7H9", "url": "https://www.uniprot.org/uniprotkb/E1B7H9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7H9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 254, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7H9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7H9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H9" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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"UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA21" } ] } ], "protein_names": [ { "name": "Transcription factor A, mitochondrial", "type": "recommended", "evidence": [ { "id": "E1BA21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA21/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.", "evidence": [ { "database": "UniProtKB", "id": "E1BA21", "url": "https://www.uniprot.org/uniprotkb/E1BA21#function" }, { "database": "UniProtKB", "id": "ARBA00045216", "url": "https://www.uniprot.org/uniprotkb/ARBA00045216#function" }, { "database": "UniProtKB", "id": "A0AAA9T955", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T955#function" }, { "database": "UniProtKB", "id": "A0AAA9T9M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BA21", "url": "https://www.uniprot.org/uniprotkb/E1BA21" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TFAM", "url": "https://www.uniprot.org/uniprotkb/E1BA21", "locus": { "chromosome": "28", "start_pos": 45668837, "end_pos": 45689736, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003546", "url": "https://www.ensembl.org/id/ENSBTAG00000003546" } ] } } ], "crossref": [ { "id": "E1BA21", "url": "https://alphafold.ebi.ac.uk/entry/E1BA21", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003546", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003546", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21986", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21986", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21987", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21987", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR009071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050342", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050342", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051762", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051762", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YMQLAED", "url": "https://omabrowser.org/oma/group/YMQLAED/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR46318", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46318", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46318:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46318:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48112", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48112", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48112:SF36", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48112:SF36", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00505", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00505", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09011", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09011", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-163282", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163282", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9837999", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9837999", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SDP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDP9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T955", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T955", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T955-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T955-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9M5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA21", "url": "https://www.uniprot.org/uniprotkb/E1BA21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA21-1", "url": "https://www.uniprot.org/uniprotkb/E1BA21-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALLRGVWGVLNALGKSGADLCAGCGSRLRSPFSFAYVPKWFSSSLSGYPKKPMTSYVRFSKEQLPIFKAQNPDAKNSELIKKIAKLWRELPDSEKKIYEDAYRADWQVYKEEINRIQEQLTPSQMVSLEKEIMQKRLKKKALIKKRELTMLGKPKRPRSAYNIFIAERFQEARDGTSQVKLKAINENWKNLSNSQKQVYIQLAKDDKIRYYNEMKSWEEQMMEVGREDLIRRSIKYPAKNDPEKF", "length": 246, "header": "tr|E1BA21-1|E1BA21_BOVIN Isoform 1 of Transcription factor A, mitochondrial OS=Bos taurus OX=9913 GN=TFAM PE=4 SV=2 CANONICAL=E1BA21-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDP9-1", "url": "https://www.uniprot.org/uniprotkb/E1BA21/entry#A0AAA9SDP9-1", "sequence": { "sequence": "MALLRGVWGVLNALGKSGADLCAGCGSRLRSPFSFAYVPKWFSSSLSGYPKKPMTSYVRFSKEQLPIFKAQNPDAKNSELIKKIAKLWRELPDSEKKIYEDAYRADWQVYKEEINRIQEQLTPSQMVSLEKEIMQKRLKKKALIKKRVKLKAINENWKNLSNSQKQVYIQLAKDDKIRYYNEMKSWEEQMMEVGREDLIRRSIKYPAKNDPEKF", "length": 214, "header": "tr|A0AAA9SDP9-1|E1BA21_BOVIN Computationally mapped isoform of Transcription factor A, mitochondrial OS=Bos taurus OX=9913 GN=TFAM PE=4 SV=1 CANONICAL=E1BA21-1" }, "locus": { "chromosome": "28", "start_pos": 45689417, "end_pos": 45677902, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122549.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122549.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081937.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081937.1" } ] } }, { "isoform_ac": "A0AAA9SQJ6-1", "url": "https://www.uniprot.org/uniprotkb/E1BA21/entry#A0AAA9SQJ6-1", "sequence": { "sequence": "MALLRGVWGVLNALGKSGADLCAGCGSRLRSPFSFAYVPKWFSSSLSGYPKKPMTSYVRFSKEQLPIFKAQNPDAKNSELIKKIAKLWRELPDSEKKIYEDAYRADWQVYKEEINRIQEQLTPSQMVSLEKEIMQKRLKKKALIKKRVSSPIISSTCVRISAGGTATSHPRPYSDPRFRSHCQLVARTPPVGQMWKCPSSRTGALAHLSRVRRDRSALGAWPVRTAGSAPGSQEQSRSCKVKRNLTWKVAHPSGDFPPGPQNP", "length": 263, "header": "tr|A0AAA9SQJ6-1|E1BA21_BOVIN Computationally mapped isoform of Transcription factor A, mitochondrial OS=Bos taurus OX=9913 GN=TFAM PE=4 SV=1 CANONICAL=E1BA21-1" }, "locus": { "chromosome": "28", "start_pos": 45689417, "end_pos": 45669245, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126710.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126710.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088609.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088609.1" } ] } }, { "isoform_ac": "A0AAA9T955-1", "url": "https://www.uniprot.org/uniprotkb/E1BA21/entry#A0AAA9T955-1", "sequence": { "sequence": "MALLRGVWGVLNALGKSGADLCAGCGSRLRSPFSFAYVPKWFSSSLSGYPKKPMTSYVRFSKEQLPIFKAQNPDAKNSELIKKIAKLWRELPDSEKKIYEDAYRADWQVYKEEINRIQEQLTPSQMVSLEKEIMQKRLKKKALIKKRELTMLGKPKRPRSAYNIFIAERFQEARDGTSQVKLKAINENWKNLSNSQKQVQLLVPRNKADLVRLRGISPGKWLIRVETSHQDHRTHEEQG", "length": 239, "header": "tr|A0AAA9T955-1|E1BA21_BOVIN Computationally mapped isoform of Transcription factor A, mitochondrial OS=Bos taurus OX=9913 GN=TFAM PE=4 SV=1 CANONICAL=E1BA21-1" }, "locus": { "chromosome": "28", "start_pos": 45689417, "end_pos": 45669232, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104555.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104555.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093141.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093141.1" } ] } }, { "isoform_ac": "A0AAA9T9M5-1", "url": "https://www.uniprot.org/uniprotkb/E1BA21/entry#A0AAA9T9M5-1", "sequence": { "sequence": "MALLRGVWGVLNALGKSGADLCAGCGSRLRSPFSFAYVPKWFSSSLSGYPKKPMTSYVRFSKEQLPIFKAQNPDAKNSELIKKIAKLWRELPDSEKKIYEDAYRADWQVYKEEINRIQEQLTPSQMVSLEKEIMQKRLKKKALIKKRELTMLGKPKRPRSAYNIFIAERFQEARDGTSQVSSPIISSTCVRISAGGTATSHPRPYSDPRFRSHCQLVARTPPVGQMWKCPSSRTGALAHLSRVRRDRSALGAWPVRTAGSAPGSQEQSRSCKVKRNLTWKVAHPSGDFPPGPQNP", "length": 295, "header": "tr|A0AAA9T9M5-1|E1BA21_BOVIN Computationally mapped isoform of Transcription factor A, mitochondrial OS=Bos taurus OX=9913 GN=TFAM PE=4 SV=1 CANONICAL=E1BA21-1" }, "locus": { "chromosome": "28", "start_pos": 45689417, "end_pos": 45669245, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123218.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123218.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092602.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092602.1" } ] } }, { "isoform_ac": "E1BA21-1", "url": "https://www.uniprot.org/uniprotkb/E1BA21/entry#E1BA21-1", "sequence": { "sequence": "MALLRGVWGVLNALGKSGADLCAGCGSRLRSPFSFAYVPKWFSSSLSGYPKKPMTSYVRFSKEQLPIFKAQNPDAKNSELIKKIAKLWRELPDSEKKIYEDAYRADWQVYKEEINRIQEQLTPSQMVSLEKEIMQKRLKKKALIKKRELTMLGKPKRPRSAYNIFIAERFQEARDGTSQVKLKAINENWKNLSNSQKQVYIQLAKDDKIRYYNEMKSWEEQMMEVGREDLIRRSIKYPAKNDPEKF", "length": 246, "header": "tr|E1BA21-1|E1BA21_BOVIN Isoform 1 of Transcription factor A, mitochondrial OS=Bos taurus OX=9913 GN=TFAM PE=4 SV=2 CANONICAL=E1BA21-1" }, "locus": { "chromosome": "28", "start_pos": 45689417, "end_pos": 45677902, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052511.3", "url": "https://www.ensembl.org/id/ENSBTAT00000052511.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052192.2", "url": "https://www.ensembl.org/id/ENSBTAP00000052192.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-163282", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163282", "resource": "Reactome", "description": "Mitochondrial transcription initiation" }, { "id": "R-BTA-9837999", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9837999", "resource": "Reactome", "description": "Mitochondrial protein degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "P40630-1", "protein_name": "Transcription factor A, mitochondrial", "gene_name": "Tfam", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFRGMWSVLKALGRTGVEMCAGCGGRIPSSISLVCIPKCFSSMGSYPKKPMSSYLRFSTEQLPKFKAKHPDAKLSELVRKIAALWRELPEAEKKVYEADFKAEWKAYKEAVSKYKEQLTPSQLMGMEKEARQRRLKKKALVKRRELILLGKPKRPRSAYNIYVSESFQEAKDDSAQGKLKLVNEAWKNLSPEEKQAYIQLAKDDRIRYDNEMKSWEEQMAEVGRSDLIRRSVKRSGDISEH", "length": 243 }, "evidence": [ { "id": "E1BA21", "url": "https://omabrowser.org/oma/group/E1BA21/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q00059-1", "protein_name": "Transcription factor A, mitochondrial", "gene_name": "TFAM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAFLRSMWGVLSALGRSGAELCTGCGSRLRSPFSFVYLPRWFSSVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELPDSKKKIYQDAYRAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKAMTKKKELTLLGKPKRPRSAYNVYVAERFQEAKGDSPQEKLKTVKENWKNLSDSEKELYIQHAKEDETRYHNEMKSWEEQMIEVGRKDLLRRTIKKQRKYGAEEC", "length": 246 }, "evidence": [ { "id": "E1BA21", "url": "https://omabrowser.org/oma/group/E1BA21/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5D144-1", "protein_name": "Transcription factor A, mitochondrial", "gene_name": "TFAM", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALLRGVWGVLSALGKSGADLCAVCGSRLRSPFSFAYVPRWFSSTLSGFPKKPMTSYVRFSKEQLPIFKAQNPDAKNSELIKKIAELWRELPDSEKKIYEDAYRADWQVYKEEVNRIQEQLTPSQMVSLEKEIMQKRLKKKALIKKRELTMLGKPKRPRSAYNIFIAERFQEAKDGPSQVKLKTINENWKNLSSSQKQVYIQLAEDDKVRYYNEMKSWEEQMVEVGRNDLIRRSMKHSAKKDTEEC", "length": 246 }, "evidence": [ { "id": "E1BA21", "url": "https://omabrowser.org/oma/group/E1BA21/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q86BR8-1", "protein_name": "Mitochondrial transcription factor A, isoform B", "gene_name": "TFAM", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MIYTTTLMSSRGGLIGSLINKVRQVVAKDWPPSDPSRANDTDHRPLTPPRPLAAASISNTPAVPSKTLEEQLGLPPRPKKPLTPYFRFMREQRPKLKAANPQITTVEVVRQLSKNWSDADAQLKERLQAEFKRDQQIYVEERTKYDATLTEEQRAEIKQLKQDLVDAKERRQLRKRVKELGRPKKPASAFLRFIASERINTPQGDKQTYREWHQKTTAKWTRLSDSEKEVYMQESRKEMELYRKAISVWEEKMIRLGHIDVVRHGNLIDPPEPKPRKTLASKDI", "length": 284 }, "evidence": [ { "id": "E1BA21", "url": "https://omabrowser.org/oma/group/E1BA21/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q91ZW1-1", "protein_name": "Transcription factor A, mitochondrial", "gene_name": "Tfam", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALFRGMWGVLRTLGRTGVEMCAGCGGRIPSPVSLICIPKCFSSLGNYPKKPMSSYLRFSTEQLPKFKAKHPDAKVSELIRKIAAMWRELPEAEKKVYEADFKAEWKVYKEAVSKYKEQLTPSQLMGLEKEARQKRLKKKAQIKRRELILLGKPKRPRSAYNIYVSESFQEAKDESAQGKLKLVNQAWKNLSHDEKQAYIQLAKDDRIRYDNEMKSWEEQMAEVGRSDLIRRSVKRPPGDISEN", "length": 244 }, "evidence": [ { "id": "E1BA21", "url": "https://omabrowser.org/oma/group/E1BA21/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BA21", "url": "https://www.uniprot.org/uniprotkb/E1BA21" } ], "pmid": "" }, { "name": "mitochondrial transcription factor activity", "id": "GO:0034246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034246", "evidence": [ { "database": "UniProtKB", "id": "E1BA21", "url": "https://www.uniprot.org/uniprotkb/E1BA21" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BA21", "url": "https://www.uniprot.org/uniprotkb/E1BA21" } ], "pmid": "" }, { "name": "mitochondrial nucleoid", "id": "GO:0042645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042645", "evidence": [ { "database": "UniProtKB", "id": "E1BA21", "url": "https://www.uniprot.org/uniprotkb/E1BA21" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BA21", "url": "https://www.uniprot.org/uniprotkb/E1BA21" } ], "pmid": "" }, { "name": "transcription initiation at mitochondrial promoter", "id": "GO:0006391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006391", "evidence": [ { "database": "UniProtKB", "id": "E1BA21", "url": "https://www.uniprot.org/uniprotkb/E1BA21" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 191, "end_pos": 193, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BA21-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 246, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BA21-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BA21" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BA21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA21" }, { "id": "PS50118", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50118" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HMG box", "eco_id": "ECO_0000259", "start_pos": 50, "end_pos": 118, "start_aa": "Pro", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 191, "end_pos": 193 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCT7-1", "uniprot_ac": "E1BCT7", "uniprot_id": "E1BCT7_BOVIN", "mass": { "chemical_mass": 145865.0, "monoisotopic_mass": 145865.0 }, "refseq": { "ac": "NP_001193007", "name": "pre-mRNA 3' end processing protein WDR33", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193007" }, "gene_names": [ { "name": "WDR33", "type": "recommended", 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"id": "NP_001193007", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193007" } ] }, { "name": "pre-mRNA 3' end processing protein WDR33", "type": "synonym", "evidence": [ { "id": "NP_001193007", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193007" } ] } ], "function": [ { "annotation": "Essential for both cleavage and polyadenylation of pre-mRNA 3' ends.", "evidence": [ { "database": "UniProtKB", "id": "E1BCT7", "url": "https://www.uniprot.org/uniprotkb/E1BCT7#function" }, { "database": "UniProtKB", "id": "ARBA00058681", "url": "https://www.uniprot.org/uniprotkb/ARBA00058681#function" }, { "database": "UniProtKB", "id": "A0AAA9SEM8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCT7", "url": "https://www.uniprot.org/uniprotkb/E1BCT7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR33", "url": "https://www.uniprot.org/uniprotkb/E1BCT7", "locus": { "chromosome": "2", "start_pos": 4785534, "end_pos": 4676998, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005987", "url": "https://www.ensembl.org/id/ENSBTAG00000005987" } ] } } ], "crossref": [ { "id": "ENSBTAG00000005987", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005987", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "541270", "url": "https://www.ncbi.nlm.nih.gov/gene/541270", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": 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"https://www.orthodb.org/?gene=E1BCT7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22836", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22836", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22836:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22836:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-159231", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159231", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-73856", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73856", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-77595", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77595", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9770562", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770562", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193007", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SEM8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEM8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEM8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTB9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTB9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCT7", "url": "https://www.uniprot.org/uniprotkb/E1BCT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCT7-1", "url": "https://www.uniprot.org/uniprotkb/E1BCT7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATEIGSPPRFFHMPRFQHQAPRQLFYKRPDFAQQQAMQQLTFDGKRMRKAVNRKTIDYNPSVIKYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMNAVTTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMRDRYNLNLLPGMSEDGVEYDDLEPNSLAVIPGMGIPEQLKLAMEQEQMGKDESNEIEMTIPGLDWGMEEVMQKDQKKVPQKKVPYAKPIPAQFQQAWMQNKVPIPAPNEVLNDRKEDIKLEEKKKTQAEIEQEMATLQYTNPQLLEQLKIERLAQKQAEQIQPPPSSGTPLLGPQPFPGQGPMSQIPQGFQQPHPSQQLSMNMAQMGPPGPQGQFRPPGPQGQMGPQGPPLHQGGGGPQGFMGPQGPQGPPQGLPRPQDMHGPQGIQRHPGPHGPLGPQGPPGPQGNAGPQGHMGPQGPPGPQGHIGPQGPPGPQGHLGPQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLMGLNPRGMQGPPGPRENQGPAPQGMMLGHPPQEMRGPHPPSGLLGHGPQEMRGPQEMRGMQGPPPQGSMLGPPQELRGPPGSQGQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPIPFQQQKTALLGDGPRAPFNQEGQNAGPPPLIPGLGQQGAQGRIPPLNPGQGPGPNKGDSRGPPNHHMGPMSERRHEQSSGPEHGPERGPFRGSQDCRGPPDRRGPHPEFPDDFSRPDDFHPDKRFGHRLREFEGRGGPLPQEEKWRRGGPGPPFPPDHREFSEGDARGAARGPPGAWEGRRPGDDRFPRDPEDPRFRGRREESFRRGAPPRHEGRAPPRGRDGFPGPEDFGPEENFDASDETARGRDLRGRGRGTPRGGRKGLLPTPDEFPRFEGGRKPDSWDGNREPGPGHEHFRDAPRPDHPPHDGHSPASRERSSSLQGMDMASLPPRKRPWHDGPGTSEHREMDAPGGPSEDRGGKGRGGPGPSQRVPKSGRSSSLDGDHHDGYHRDEPFGGPPGSGTPSRGGRSGSNWGRGSNMNSGPPRRGASRGGGRGR", "length": 1336, "header": "tr|E1BCT7-1|E1BCT7_BOVIN Isoform 1 of pre-mRNA 3' end processing protein WDR33 OS=Bos taurus OX=9913 GN=WDR33 PE=3 SV=1 CANONICAL=E1BCT7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEM8-1", "url": "https://www.uniprot.org/uniprotkb/E1BCT7/entry#A0AAA9SEM8-1", "sequence": { "sequence": 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"length": 1282, "header": "tr|A0AAA9SEM8-1|E1BCT7_BOVIN Computationally mapped isoform of pre-mRNA 3' end processing protein WDR33 OS=Bos taurus OX=9913 GN=WDR33 PE=3 SV=1 CANONICAL=E1BCT7-1" }, "locus": { "chromosome": "2", "start_pos": 4785058, "end_pos": 4724678, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087689.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087689.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084580.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084580.1" } ] } }, { "isoform_ac": "A0AAA9TTB9-1", "url": "https://www.uniprot.org/uniprotkb/E1BCT7/entry#A0AAA9TTB9-1", "sequence": { "sequence": "MATEIGSPPRFFHMPRFQHQAPRQLFYKRPDFAQQQAMQQLTFDGKRMRKAVNRKTIDYNPSVIKYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMNAVTTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNNVKMFQAHKEAIREARFIHNIPFSVVPIVMVKLFSKCILGAEMHGFCQILGNFLHPINTIFFFVFTHSPFCWHFSEVVLSRYEPLQYVRDVLSAAFCTGFLFSFMVNNVYTLFIFITYYVREYLIPNKEFSL", "length": 325, "header": "tr|A0AAA9TTB9-1|E1BCT7_BOVIN Computationally mapped isoform of pre-mRNA 3' end processing protein WDR33 OS=Bos taurus OX=9913 GN=WDR33 PE=3 SV=1 CANONICAL=E1BCT7-1" }, "locus": { "chromosome": "2", "start_pos": 4729886, "end_pos": 4724678, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110040.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110040.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100317.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100317.1" } ] } }, { "isoform_ac": "E1BCT7-1", "url": "https://www.uniprot.org/uniprotkb/E1BCT7/entry#E1BCT7-1", "sequence": { "sequence": "MATEIGSPPRFFHMPRFQHQAPRQLFYKRPDFAQQQAMQQLTFDGKRMRKAVNRKTIDYNPSVIKYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMNAVTTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMRDRYNLNLLPGMSEDGVEYDDLEPNSLAVIPGMGIPEQLKLAMEQEQMGKDESNEIEMTIPGLDWGMEEVMQKDQKKVPQKKVPYAKPIPAQFQQAWMQNKVPIPAPNEVLNDRKEDIKLEEKKKTQAEIEQEMATLQYTNPQLLEQLKIERLAQKQAEQIQPPPSSGTPLLGPQPFPGQGPMSQIPQGFQQPHPSQQLSMNMAQMGPPGPQGQFRPPGPQGQMGPQGPPLHQGGGGPQGFMGPQGPQGPPQGLPRPQDMHGPQGIQRHPGPHGPLGPQGPPGPQGNAGPQGHMGPQGPPGPQGHIGPQGPPGPQGHLGPQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLMGLNPRGMQGPPGPRENQGPAPQGMMLGHPPQEMRGPHPPSGLLGHGPQEMRGPQEMRGMQGPPPQGSMLGPPQELRGPPGSQGQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPIPFQQQKTALLGDGPRAPFNQEGQNAGPPPLIPGLGQQGAQGRIPPLNPGQGPGPNKGDSRGPPNHHMGPMSERRHEQSSGPEHGPERGPFRGSQDCRGPPDRRGPHPEFPDDFSRPDDFHPDKRFGHRLREFEGRGGPLPQEEKWRRGGPGPPFPPDHREFSEGDARGAARGPPGAWEGRRPGDDRFPRDPEDPRFRGRREESFRRGAPPRHEGRAPPRGRDGFPGPEDFGPEENFDASDETARGRDLRGRGRGTPRGGRKGLLPTPDEFPRFEGGRKPDSWDGNREPGPGHEHFRDAPRPDHPPHDGHSPASRERSSSLQGMDMASLPPRKRPWHDGPGTSEHREMDAPGGPSEDRGGKGRGGPGPSQRVPKSGRSSSLDGDHHDGYHRDEPFGGPPGSGTPSRGGRSGSNWGRGSNMNSGPPRRGASRGGGRGR", "length": 1336, "header": "tr|E1BCT7-1|E1BCT7_BOVIN Isoform 1 of pre-mRNA 3' end processing protein WDR33 OS=Bos taurus OX=9913 GN=WDR33 PE=3 SV=1 CANONICAL=E1BCT7-1" }, "locus": { "chromosome": "2", "start_pos": 4785111, "end_pos": 4724678, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007859.5", "url": "https://www.ensembl.org/id/ENSBTAT00000007859.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007859.4", "url": "https://www.ensembl.org/id/ENSBTAP00000007859.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1302, "start_aa": "Thr", "end_pos": 1302, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1302", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:541270", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541270", "resource": "KEGG Pathway" }, { "id": "R-BTA-159231", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159231", "resource": "Reactome", "description": "Transport of Mature mRNA Derived from an Intronless Transcript" }, { "id": "R-BTA-73856", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73856", "resource": "Reactome", "description": "RNA Polymerase II Transcription Termination" }, { "id": "R-BTA-77595", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77595", "resource": "Reactome", "description": "Processing of Intronless Pre-mRNAs" }, { "id": "R-BTA-9770562", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770562", "resource": "Reactome", "description": "mRNA Polyadenylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZXY5-1", "protein_name": "pre-mRNA 3' end processing protein WDR33", "gene_name": "WDR33", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAGRGGDEARRAAGREGAGRDAGWTHFRNEIAMATEIGSPPRFFHMPRFQHQAPRQLFYKRPDFAQQQAMQQLTFDGKRMRKAVNRKTIDYNPSVIKYLENRVWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMNAVTTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMRDRYNLNLLPGMSEDGVEYDDLEPNSLAVIPGMGIPEQLKIAMEQEQMGKDESNDIEMTIPGLDWGMEEVMQKDQKKVPQKKVPYAKPIPAQFQQAWMQNKVPLPPPPEPLIDRKEDIKLEEKKKTQAEIEQEMAALQYTNPQLLEQLKIERLAQKQAEQVQPPPGGSLHGPQPFPGQGPMSQMPQGFQQPLPPQQIPMNMPQMGPPGPQGQFRPPGPQGQMGPQGPPLHQGGGGPQGFMGPQGPPGPHGPQGMPRPQDLHGHQGMQRHPGPHGPMGPPGPQGNAGPQGHLGPQGLPGSQTHLGPQGPPGPQGNLGPQGQGMQGPPGPRGMQGPLPHGMQGAPGSQGMQGPISQGPLMGLNPRGMQGPPGPRDNQGPTPQGMMMGHPQEMRGPHMQSGLLGHGPQEMRGLQGPPPQGAMLGPPQEMRGPQGQQGPPQGSMVGPQGNMQGPQGQPNPSRGPHPSQGPLPFQQQKTPLLGDGPRPPFNQDGQNPGPPPLIPGLGQQGGQGRLGPHNQGPGLNKGDSRGPPNHHMGPLSDRRHDQNSGGPDHGPERGLFRGGQEWGDGRDSRGMPDRRGPHPDFHDDFDRPDDFRDDFHPDKRFGHRLREFEGRGGPPLQDEKWRRGGPGPPFPPDHREFEGGGSNRGPPGAWEGRRPSDDRYPRDPEDARFRGRRDESFRRGGPSRHEGRGPRGRDGFPGPEDFGPDDTFDSPDENLRGRDHGARGRGRGAIRGGRKGLLPTPDEIPRFEGGRKPESWDGNREPGPRPDHPPHDGHSPANRERSSSLQGMDMASLPPRKRPWHDGPGTSDPREMDAPGGPPEERGKGRGNSGASQRAPKSARSNSLDGDHHDGFHRDEAFGGGPAGGSNPSRGGRSGSNWGRGNNMNSGQSRRGASRGGGRGR", "length": 1345 }, "evidence": [ { "id": "E1BCT7", "url": "https://omabrowser.org/oma/group/E1BCT7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3L6Y7-1", "protein_name": "pre-mRNA 3' end processing protein WDR33", "gene_name": "WDR33", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATEIGSPPRFFHMPRFQHQAPRQLFYKRPDFAQQQAMQQLTFDGKRMRKAVNRKTIDYNPSVIKYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMNAVTTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMRDRYNLNLLPGMSEDGVEYDDLEPNSLAVIPGMGIPEQLKLAMEQEQMGKDESNEIEMTIPGLDWGMEEVMQKDQKKVPQKKVPYAKPIPAQFQQAWMQNKVPIPTPNEVLNDRKEDIKLEEKKKTQAEIEQEMATLQYTNPQLLEQLKIERLAQKQAEQIQPPPSSGTPLLGPQPFPGQGPMSQIPQGFQQPHPSQQMPMNMAQMGPPGPQGQFRPPGPQGQMGPQGPPLHQGGGGPQGFMGPQGPQGPPQGLPRPQDMHGPQGMQRHPGPHGPLGPQGPPGPQGNSGPQGHMGPQGPPGPQGHIGPQGPPGPQGHLGPQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLMGLNPRGMQGPPGPRETQGPAPQGMMLGHPPQEMRGPHPPSGLLGHGPQEMRGPQEMRGMQGPPPQGSMLGPPQELRGPPGSQGQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPIPFQQQKTALLGDGPRAPFNQEGQNAGPPPLIPGLGQQGAQGRIPPLNPGQGPGPNKGDSRGPPNHHMGPMSERRHEQSGGPEHGPERGPFRGAQDCRGPPDRRGPHPDFPDDFSRPDDFHPDKRFGHRLREFEGRGGPLPQEEKWRRGGPGPPFPPDHREFSDGDGRGAARGPPGAWESRRPGDERFPRDPEDPRFRGRREESFRRGAPPRHEGRAPPRGRDGFPGPEDFGPEESFDAADEAARGRDLRGRGRGTPRGGRKGLLPTPDEFPRFEGGRKPDSWDGNRESGPGHEHFRDAPRPDHPPHDGHSPAGRERSSSLQGMDMASLPPRKRPWHDGPGTSEHREMEAPGGPSEDRGGKGRGGPGPSQRVPKSGRSSSLDGDHHDGYHRDEPFGGPPGSGTPSRGGRSGSNWGRGSNMNSGPPRRGASRGGGRGR", "length": 1336 }, "evidence": [ { "id": "E1BCT7", "url": "https://omabrowser.org/oma/group/E1BCT7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8K4P0-1", "protein_name": "pre-mRNA 3' end processing protein WDR33", "gene_name": "Wdr33", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATEIGSPPRFFHMPRFQHQAPRQLFYKRPDFAQQQAMQQLTFDGKRMRKAVNRKTIDYNPSVIKYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMNAVTTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMRDRYNLNLLPGMSEDGVEYDDLEPNSLAVIPGMGIPEQLKLAMEQEQMGKDESSEIEMTIPGLDWGMEEVMQKDQKKVPQKKVPYAKPIPAQFQQAWMQNKVPIPAPNEVLNDRKEDIKLEEKKKTQAEIEQEMATLQYTNPQLLEQLKIERLAQKQADQIQPPPSSGTPLLGPQPFSGQGPISQIPQGFQQPHPSQQMPLVPQMGPPGPQGQFRAPGPQGQMGPQGPPMHQGGGGPQGFMGPQGPQGPPQGLPRPQDMHGPQGMQRHPGPHGPLGPQGPPGPQGSSGPQGHMGPQGPPGPQGHIGPQGPPASQGHMGPQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPASQGIQGPLMGLNPRGMQGPPGPRENQGPAPQGLMIGHPPQEMRGPHPPSGLLGHGPQEMRGPQEMRGMQGPPPQGSMLGPPQELRGPSGSQGQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPIPFQQQKAPLLGDGPRAPFNQEGQSTGPPPLIPGLGQQGAQGRIPPLNPGQGPGPNKGDTRGPPNHHLGPMSERRHEQSGGPEHGPDRGPFRGGQDCRGPPDRRGSHPDFPDDFRPDDFHPDKRFGHRLREFEGRGGPLPQEEKWRRGGPGPPFPPDHREFNEGDGRGAARGPPGAWEGRRPGDDRFPRDPDDPRFRGRREESFRRGAPPRHEGRAPPRGRDNFPGPDDFGPEEGFDASDEAARGRDLRGRGRGTPRGGSRKCLLPTPDEFPRFEGGRKPDSWDGNREPGPGHEHFRDAPRPDHPPHDGHSPASRERSSSLQGMDMASLPPRKRPWHDGSGTSEHREMEAQGGPSEDRGSKGRGGPGPSQRVPKSGRSSSLDGDHHDGYHRDEPFGGPPGSSSSSRGARSGSNWGRGSNMNSGPPRRGTSRGSGRGR", "length": 1330 }, "evidence": [ { "id": "E1BCT7", "url": "https://omabrowser.org/oma/group/E1BCT7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9C0J8-1", "protein_name": "pre-mRNA 3' end processing protein WDR33", "gene_name": "WDR33", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATEIGSPPRFFHMPRFQHQAPRQLFYKRPDFAQQQAMQQLTFDGKRMRKAVNRKTIDYNPSVIKYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMNAVTTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMRDRYNLNLLPGMSEDGVEYDDLEPNSLAVIPGMGIPEQLKLAMEQEQMGKDESNEIEMTIPGLDWGMEEVMQKDQKKVPQKKVPYAKPIPAQFQQAWMQNKVPIPAPNEVLNDRKEDIKLEEKKKTQAEIEQEMATLQYTNPQLLEQLKIERLAQKQVEQIQPPPSSGTPLLGPQPFPGQGPMSQIPQGFQQPHPSQQMPMNMAQMGPPGPQGQFRPPGPQGQMGPQGPPLHQGGGGPQGFMGPQGPQGPPQGLPRPQDMHGPQGMQRHPGPHGPLGPQGPPGPQGSSGPQGHMGPQGPPGPQGHIGPQGPPGPQGHLGPQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLMGLNPRGMQGPPGPRENQGPAPQGMIMGHPPQEMRGPHPPGGLLGHGPQEMRGPQEIRGMQGPPPQGSMLGPPQELRGPPGSQSQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPIPFQQQKTPLLGDGPRAPFNQEGQSTGPPPLIPGLGQQGAQGRIPPLNPGQGPGPNKGDSRGPPNHHMGPMSERRHEQSGGPEHGPERGPFRGGQDCRGPPDRRGPHPDFPDDFSRPDDFHPDKRFGHRLREFEGRGGPLPQEEKWRRGGPGPPFPPDHREFSEGDGRGAARGPPGAWEGRRPGDERFPRDPEDPRFRGRREESFRRGAPPRHEGRAPPRGRDGFPGPEDFGPEENFDASEEAARGRDLRGRGRGTPRGGRKGLLPTPDEFPRFEGGRKPDSWDGNREPGPGHEHFRDTPRPDHPPHDGHSPASRERSSSLQGMDMASLPPRKRPWHDGPGTSEHREMEAPGGPSEDRGGKGRGGPGPAQRVPKSGRSSSLDGEHHDGYHRDEPFGGPPGSGTPSRGGRSGSNWGRGSNMNSGPPRRGASRGGGRGR", "length": 1336 }, "evidence": [ { "id": "E1BCT7", "url": "https://omabrowser.org/oma/group/E1BCT7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BCT7", "url": "https://www.uniprot.org/uniprotkb/E1BCT7" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BCT7", "url": "https://www.uniprot.org/uniprotkb/E1BCT7" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "E1BCT7", "url": "https://www.uniprot.org/uniprotkb/E1BCT7" } ], "pmid": "" }, { "name": "mRNA cleavage and polyadenylation specificity factor complex", "id": "GO:0005847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005847", "evidence": [ { "database": "UniProtKB", "id": "E1BCT7", "url": "https://www.uniprot.org/uniprotkb/E1BCT7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA 3'-end processing", "id": "GO:0031124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031124", "evidence": [ { "database": "UniProtKB", "id": "E1BCT7", "url": "https://www.uniprot.org/uniprotkb/E1BCT7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1302 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCI8-1", "uniprot_ac": "E1BCI8", "uniprot_id": "E1BCI8_BOVIN", "mass": { "chemical_mass": 121083.0, "monoisotopic_mass": 121083.0 }, "refseq": { "ac": "XP_059732799", "name": "solute carrier family 12 member 4 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059732799" }, "gene_names": [ { "name": "SLC12A4", "type": "recommended", "evidence": [ { "id": "E1BCI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCI8" } ] }, { "name": "SLC12A4", "type": "synonym", "evidence": [ { "id": "XP_059732799", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059732799" } ] } ], "protein_names": [ { "name": "Solute carrier family 12 member 4", "type": "synonym", "evidence": [ { "id": "E1BCI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCI8/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 12 member 4 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059732799", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059732799" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCI8", "url": "https://www.uniprot.org/uniprotkb/E1BCI8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC12A4", "url": "https://www.uniprot.org/uniprotkb/E1BCI8", "locus": { "chromosome": "18", "start_pos": 35425243, "end_pos": 35447064, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018045", "url": "https://www.ensembl.org/id/ENSBTAG00000018045" } ] } } ], "crossref": [ { "id": "E1BCI8", "url": "https://alphafold.ebi.ac.uk/entry/E1BCI8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018045", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018045", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533876", "url": "https://www.ncbi.nlm.nih.gov/gene/533876", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000076", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000076", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000622", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000622", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004842", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004842", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018491", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018491", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BCI8", "url": "https://www.orthodb.org/?gene=E1BCI8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11827", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11827:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00324", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00324", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03522", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03522", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-426117", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-426117", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059732799", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059732799", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "72427", "url": "https://www.rhea-db.org/rhea/72427", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SF32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF32-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCI8", "url": "https://www.uniprot.org/uniprotkb/E1BCI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCI8-1", "url": "https://www.uniprot.org/uniprotkb/E1BCI8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERADREDADGHGNHKESSPFLCPMEASRGSDYHDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGARRRAAKAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPIGTHDTSSATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDVCAKTAVVDNETVATQLWSLFCHGPNLTAESCDPYFLLNNVTEIPGIPGAAAGVLQENLWSAYLEKGEVVEKHGLPSTDALGLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIVTTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKANGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNTVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAIFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAAGTDKIQMTWTRDKYMATEPWDPSHTPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPKNSEGDENWILWWGGGQCMRSGWELLSLDALGVCRVPQLCLMG", "length": 1091, "header": "tr|E1BCI8-1|E1BCI8_BOVIN Isoform 1 of Solute carrier family 12 member 4 OS=Bos taurus OX=9913 GN=SLC12A4 PE=3 SV=2 CANONICAL=E1BCI8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SF32-1", "url": "https://www.uniprot.org/uniprotkb/E1BCI8/entry#A0AAA9SF32-1", "sequence": { "sequence": "MGDILHPGHGNHKESSPFLCPMEASRGSDYHDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGARRRAAKAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPIGTHDTSSATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDVCAKTAVVDNETVATQLWSLFCHGPNLTAESCDPYFLLNNVTEIPGIPGAAAGVLQENLWSAYLEKGEVVEKHGLPSTDALGLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIVTTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKANGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNTVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAIFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAAGTDKIQMTWTRDKYMATEPWDPSHTPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPKNSEGDENWILWWGGGQCMRSGWELLSLDALGVCRVPQLCLMG", "length": 1060, "header": "tr|A0AAA9SF32-1|E1BCI8_BOVIN Computationally mapped isoform of Solute carrier family 12 member 4 OS=Bos taurus OX=9913 GN=SLC12A4 PE=3 SV=1 CANONICAL=E1BCI8-1" }, "locus": { "chromosome": "18", "start_pos": 35445229, "end_pos": 35425846, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091229.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091229.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082214.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082214.1" } ] } }, { "isoform_ac": "E1BCI8-1", "url": "https://www.uniprot.org/uniprotkb/E1BCI8/entry#E1BCI8-1", "sequence": { "sequence": "MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERADREDADGHGNHKESSPFLCPMEASRGSDYHDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGARRRAAKAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPIGTHDTSSATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDVCAKTAVVDNETVATQLWSLFCHGPNLTAESCDPYFLLNNVTEIPGIPGAAAGVLQENLWSAYLEKGEVVEKHGLPSTDALGLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIVTTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKANGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNTVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAIFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAAGTDKIQMTWTRDKYMATEPWDPSHTPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPKNSEGDENWILWWGGGQCMRSGWELLSLDALGVCRVPQLCLMG", "length": 1091, "header": "tr|E1BCI8-1|E1BCI8_BOVIN Isoform 1 of Solute carrier family 12 member 4 OS=Bos taurus OX=9913 GN=SLC12A4 PE=3 SV=2 CANONICAL=E1BCI8-1" }, "locus": { "chromosome": "18", "start_pos": 35447004, "end_pos": 35425846, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024019.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024019.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024019.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024019.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-426117", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-426117", "resource": "Reactome", "description": "Cation-coupled Chloride cotransporters" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BCI8", "url": "https://www.uniprot.org/uniprotkb/E1BCI8" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "E1BCI8", "url": "https://www.uniprot.org/uniprotkb/E1BCI8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "potassium:chloride symporter activity", "id": "GO:0015379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015379", "evidence": [ { "database": "UniProtKB", "id": "E1BCI8", "url": "https://www.uniprot.org/uniprotkb/E1BCI8" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1BCI8", "url": "https://www.uniprot.org/uniprotkb/E1BCI8" } ], "pmid": "" }, { "name": "protein serine/threonine kinase binding", "id": "GO:0120283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120283", "evidence": [ { "database": "UniProtKB", "id": "E1BCI8", "url": "https://www.uniprot.org/uniprotkb/E1BCI8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "E1BCI8", "url": "https://www.uniprot.org/uniprotkb/E1BCI8" } ], "pmid": "" }, { "name": "cell volume homeostasis", "id": "GO:0006884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006884", "evidence": [ { "database": "UniProtKB", "id": "E1BCI8", "url": "https://www.uniprot.org/uniprotkb/E1BCI8" } ], "pmid": "" }, { "name": "chloride transmembrane transport", "id": "GO:1902476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902476", "evidence": [ { "database": "UniProtKB", "id": "E1BCI8", "url": "https://www.uniprot.org/uniprotkb/E1BCI8" } ], "pmid": "" }, { "name": "potassium ion homeostasis", "id": "GO:0055075", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055075", "evidence": [ { "database": "UniProtKB", "id": "E1BCI8", "url": "https://www.uniprot.org/uniprotkb/E1BCI8" } ], "pmid": "" }, { "name": "potassium ion import across plasma membrane", "id": "GO:1990573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990573", "evidence": [ { "database": "UniProtKB", "id": "E1BCI8", "url": "https://www.uniprot.org/uniprotkb/E1BCI8" } ], "pmid": "" }, { "name": "chloride ion homeostasis", "id": "GO:0055064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055064", "evidence": [ { "database": "UniProtKB", "id": "E1BCI8", "url": "https://www.uniprot.org/uniprotkb/E1BCI8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 312, "end_pos": 314, "annotation": "n_glycosylation_sequon" }, { "start_pos": 331, "end_pos": 333, "annotation": "n_glycosylation_sequon" }, { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 361, "end_pos": 363, "annotation": "n_glycosylation_sequon" }, { "start_pos": 439, "end_pos": 441, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "72427", "name": "", "equation": "K(+)(in) + chloride(in) = K(+)(out) + chloride(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "72427", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/72427" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCI8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1091, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCI8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCI8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCI8" }, { "id": "PF00324", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00324" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Amino acid permease/ SLC12A", "eco_id": "ECO_0000259", "start_pos": 124, "end_pos": 300, "start_aa": "Val", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BCI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCI8" }, { "id": "PF03522", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03522" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SLC12A transporter C-terminal", "eco_id": "ECO_0000259", "start_pos": 709, "end_pos": 825, "start_aa": "Pro", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 312, "end_pos": 314 }, { "start_pos": 331, "end_pos": 333 }, { "start_pos": 347, "end_pos": 349 }, { "start_pos": 361, "end_pos": 363 }, { "start_pos": 439, "end_pos": 441 }, { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { 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"count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BAP3-1", "uniprot_ac": "E1BAP3", "uniprot_id": "E1BAP3_BOVIN", "mass": { "chemical_mass": 83465.0, "monoisotopic_mass": 83465.0 }, "refseq": { "ac": "XP_015315341", "name": "sp110 nuclear body protein isoform X5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015315341" }, "gene_names": [ { "name": "SP110", "type": "recommended", "evidence": [ { "id": "E1BAP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAP3" } ] }, { "name": "SP110", "type": "synonym", "evidence": [ { "id": "XP_015315341", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015315341" } ] } ], "protein_names": [ { "name": "SP110 nuclear body protein", "type": "synonym", "evidence": [ { "id": "E1BAP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAP3/entry#names_and_taxonomy" } ] }, { "name": "sp110 nuclear body protein isoform X5", "type": "synonym", "evidence": [ { "id": "XP_015315341", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015315341" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAP3", "url": "https://www.uniprot.org/uniprotkb/E1BAP3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SP110", "url": "https://www.uniprot.org/uniprotkb/E1BAP3", "locus": { "chromosome": "2", "start_pos": 118183289, "end_pos": 118232898, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015752", "url": "https://www.ensembl.org/id/ENSBTAG00000015752" } ] } } ], "crossref": [ { "id": "E1BAP3", "url": "https://alphafold.ebi.ac.uk/entry/E1BAP3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015752", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015752", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15626", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15626", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515204", "url": "https://www.ncbi.nlm.nih.gov/gene/515204", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001487", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001487", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043563", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043563", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BAP3", "url": "https://www.orthodb.org/?gene=E1BAP3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46386", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46386", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46386:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46386:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01342", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01342", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03172", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03172", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015315341", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015315341", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SF64", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF64-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAP3", "url": "https://www.uniprot.org/uniprotkb/E1BAP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAP3-1", "url": "https://www.uniprot.org/uniprotkb/E1BAP3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTRALEKALLQHFIQQKLEIAYAINKPFPFFEGLRDNFFITERLYRESMEACENLVPLSRVVYNILTQLEKTFSLSFLKILFSQINLNEYPNLITTLNSFTRVVTSHGGWSRITTTLLEAPANPAGRSSPRTLLLPRLPCRQPLRSLPPCGPSVSERAPAQRSSEVLRELPSRTGLTMTLRETIQKGRLSPVSSDSLTPQIKDKEDTQEMPCTSSDPVPVKRDDVPEPSDPKELQEASRTLPSKKGKKRKRCIWATSKKRQQKNSHQGSKMRKQEGAGGQRQLIPVDQGAALPGHGIQKTLQGLDQVTHTEDDSIRNTKVMTRTQKRRTECAQMPKSEEISDNTSEMDEGKRSQEPPSTPPRITHGKDSMDDDSKLSLEKSPGKKRAASSGLRIQEKLQGVNQVTQKKDDSTRKSTVMTRARKAQAEGARMPAQKDKAGGGTGHLNAQRGRVSHGARTEKPKDKTIDFHSPELPVTCGEAKGILYKEKMKQGSSKKCIQNEKGVWFTPTEFEIEGKRKHSRNWKHSVFCGGKSLGKLLQNGILFCPSRKHLKTEQENSKECAVCCKGGSLLRCDTCPRFFHEDCHIPPAEAERSPWSCTFCRMKESSGNQQGLQESEVWARSMQLEEQLKCEFLLLKAYCHPQSSFFAETPCNIRDYGEPFREAMWLDLVKERLTEKVYTMAWFLRDMRLIFHNHKTFYKASDFGQVGLDLEAEFEKDLKEVLICHEVSDNSFQAHP", "length": 737, "header": "tr|E1BAP3-1|E1BAP3_BOVIN Isoform 1 of SP110 nuclear body protein OS=Bos taurus OX=9913 GN=SP110 PE=4 SV=4 CANONICAL=E1BAP3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SF64-1", "url": "https://www.uniprot.org/uniprotkb/E1BAP3/entry#A0AAA9SF64-1", "sequence": { "sequence": "MTRALEKALLQHFIQQKLEIAYAINKPFPFFEGLRDNFFITERLYRESMEACENLVPLSRVVYNILTQLEKTFSLSFLKILFSQINLNEYPNLITTLNSFTRVVTSHGGWSRITTTLLEAPANPAGRSSPRTLLLPRLPCRQPLRSLPPCGPSVSERAPAQRSSEVLRELPSRTGLTMTLRETIQKGRLSPVSSDSLTPQIKDKEDTQEMPCTSSDPVPVKRDDVPEPSDPKELQEASRTLPSKKGKKRKRCIWATSKKRQQKNSHQGSKMRKQEGAGGQRQLIPVDQGAALPGHGIQKTLQGLDQVTHTEDDSIRNTKVMTRTQKRRTECAQMPKSEEISDNTSEMDEGKRSQEPPSTPPRITHGKDSMDDDSKLSLEKSPGKKRAASSGLRIQEKLQGVNQVTQKKDDSTRKSTVMTRARKAQAEGARMPAQKDKAGGGTGHLNAQRGRVSHGARTEKPKDKTIDFHSPELPVTCGEAKGILYKEKMKQGSSKKCIQNEKGVWFTPTEFEIEGKRKHSRNWKHSVFCGGKSLGKLLQNGILFCPSRKHLKTEVNSR", "length": 558, "header": "tr|A0AAA9SF64-1|E1BAP3_BOVIN Computationally mapped isoform of SP110 nuclear body protein OS=Bos taurus OX=9913 GN=SP110 PE=4 SV=2 CANONICAL=E1BAP3-1" }, "locus": { "chromosome": "2", "start_pos": 118230749, "end_pos": 118193628, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106477.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106477.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081084.2", "url": "https://www.ensembl.org/id/ENSBTAP00000081084.2" } ] } }, { "isoform_ac": "E1BAP3-1", "url": "https://www.uniprot.org/uniprotkb/E1BAP3/entry#E1BAP3-1", "sequence": { "sequence": "MTRALEKALLQHFIQQKLEIAYAINKPFPFFEGLRDNFFITERLYRESMEACENLVPLSRVVYNILTQLEKTFSLSFLKILFSQINLNEYPNLITTLNSFTRVVTSHGGWSRITTTLLEAPANPAGRSSPRTLLLPRLPCRQPLRSLPPCGPSVSERAPAQRSSEVLRELPSRTGLTMTLRETIQKGRLSPVSSDSLTPQIKDKEDTQEMPCTSSDPVPVKRDDVPEPSDPKELQEASRTLPSKKGKKRKRCIWATSKKRQQKNSHQGSKMRKQEGAGGQRQLIPVDQGAALPGHGIQKTLQGLDQVTHTEDDSIRNTKVMTRTQKRRTECAQMPKSEEISDNTSEMDEGKRSQEPPSTPPRITHGKDSMDDDSKLSLEKSPGKKRAASSGLRIQEKLQGVNQVTQKKDDSTRKSTVMTRARKAQAEGARMPAQKDKAGGGTGHLNAQRGRVSHGARTEKPKDKTIDFHSPELPVTCGEAKGILYKEKMKQGSSKKCIQNEKGVWFTPTEFEIEGKRKHSRNWKHSVFCGGKSLGKLLQNGILFCPSRKHLKTEQENSKECAVCCKGGSLLRCDTCPRFFHEDCHIPPAEAERSPWSCTFCRMKESSGNQQGLQESEVWARSMQLEEQLKCEFLLLKAYCHPQSSFFAETPCNIRDYGEPFREAMWLDLVKERLTEKVYTMAWFLRDMRLIFHNHKTFYKASDFGQVGLDLEAEFEKDLKEVLICHEVSDNSFQAHP", "length": 737, "header": "tr|E1BAP3-1|E1BAP3_BOVIN Isoform 1 of SP110 nuclear body protein OS=Bos taurus OX=9913 GN=SP110 PE=4 SV=4 CANONICAL=E1BAP3-1" }, "locus": { "chromosome": "2", "start_pos": 118230749, "end_pos": 118183524, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020915.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020915.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020915.7", "url": "https://www.ensembl.org/id/ENSBTAP00000020915.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BAP3", "url": "https://www.uniprot.org/uniprotkb/E1BAP3" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BAP3", "url": "https://www.uniprot.org/uniprotkb/E1BAP3" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BAP3", "url": "https://www.uniprot.org/uniprotkb/E1BAP3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BAP3", "url": "https://www.uniprot.org/uniprotkb/E1BAP3" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BAP3", "url": "https://www.uniprot.org/uniprotkb/E1BAP3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BAP3", "url": "https://www.uniprot.org/uniprotkb/E1BAP3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 343, "end_pos": 345, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAP3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 737, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAP3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAP3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAP3" }, { "id": "PS51414", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51414" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HSR", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 105, "start_aa": "Met", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BAP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAP3" }, { "id": "PS50016", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50016" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PHD-type", "eco_id": "ECO_0000259", "start_pos": 558, "end_pos": 604, "start_aa": "Ser", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BAP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAP3" }, { "id": "PS50864", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50864" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAND", "eco_id": "ECO_0000259", "start_pos": 463, "end_pos": 544, "start_aa": "Asp", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 343, "end_pos": 345 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BC47-1", "uniprot_ac": "E1BC47", "uniprot_id": "E1BC47_BOVIN", "mass": { "chemical_mass": 28148.0, "monoisotopic_mass": 28148.0 }, "refseq": { "ac": "NP_001193188", "name": "cysteine-rich secretory protein 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193188" }, "gene_names": [ { "name": "CRISP1", "type": "recommended", "evidence": [ { "id": "E1BC47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC47" } ] }, { "name": "CRISP1", "type": "synonym", "evidence": [ { "id": "NP_001193188", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193188" } ] } ], "protein_names": [ { "name": "Cysteine rich secretory protein 1", "type": "synonym", "evidence": [ { "id": "E1BC47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC47/entry#names_and_taxonomy" } ] }, { "name": "cysteine-rich secretory protein 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001193188", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193188" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BC47", "url": "https://www.uniprot.org/uniprotkb/E1BC47" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CRISP1", "url": "https://www.uniprot.org/uniprotkb/E1BC47", "locus": { "chromosome": "23", "start_pos": 22527786, "end_pos": 22544257, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008085", "url": "https://www.ensembl.org/id/ENSBTAG00000008085" } ] } } ], "crossref": [ { "id": "E1BC47", "url": "https://alphafold.ebi.ac.uk/entry/E1BC47", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008085", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008085", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616774", "url": "https://www.ncbi.nlm.nih.gov/gene/616774", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003582", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003582", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018244", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018244", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042076", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042076", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616774", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616774", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YDEYTDC", "url": "https://omabrowser.org/oma/group/YDEYTDC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BC47", "url": "https://www.orthodb.org/?gene=E1BC47", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10334", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10334", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00188", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00188", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08562", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08562", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193188", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SFW1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFW1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC47", "url": "https://www.uniprot.org/uniprotkb/E1BC47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC47-1", "url": "https://www.uniprot.org/uniprotkb/E1BC47-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTMKCFLFLAIAAGCLPVLIIKTKPAKVPYDTLLTELEAVQEEIVTAHNILRRGVSPPASNMLKMNWSEEAAQNARMLSKDCELVQSNALKRRITNTFCGENMHLTSYPISWSNVIRIWYSESKYFQYGEWTLTDDDVTTDHYTQVVWATSYLIGCGMSSCHKGIHYLYICHYCHEGNDPDKKNVPYNKGSPCGDCPNNCEDKLCTNPCIYYDEYNNCNTQTQRLGCNHLSVQRLCKASCMCQTEIK", "length": 247, "header": "tr|E1BC47-1|E1BC47_BOVIN Isoform 1 of Cysteine rich secretory protein 1 OS=Bos taurus OX=9913 GN=CRISP1 PE=3 SV=1 CANONICAL=E1BC47-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFW1-1", "url": "https://www.uniprot.org/uniprotkb/E1BC47/entry#A0AAA9SFW1-1", "sequence": { "sequence": "MTMKCFLFLAIAAGCLPVLIIKTKPAKVPYDTLLTELEAVQEEIVTAHNILRRGVSPPASNMLKMNWSEEAAQNARMLSKDCELVQSNALKRRITNTFCGENMHLTSYPISWSNVIRIWYSESKYFQYGEWTLTDDDVTTDHYTQVVWATSYLIGCGMSSCHKGIHYLYICHYCHDE", "length": 177, "header": "tr|A0AAA9SFW1-1|E1BC47_BOVIN Computationally mapped isoform of Cysteine rich secretory protein 1 OS=Bos taurus OX=9913 GN=CRISP1 PE=3 SV=1 CANONICAL=E1BC47-1" }, "locus": { "chromosome": "23", "start_pos": 22544257, "end_pos": 22527910, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112488.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112488.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081356.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081356.1" } ] } }, { "isoform_ac": "E1BC47-1", "url": "https://www.uniprot.org/uniprotkb/E1BC47/entry#E1BC47-1", "sequence": { "sequence": "MTMKCFLFLAIAAGCLPVLIIKTKPAKVPYDTLLTELEAVQEEIVTAHNILRRGVSPPASNMLKMNWSEEAAQNARMLSKDCELVQSNALKRRITNTFCGENMHLTSYPISWSNVIRIWYSESKYFQYGEWTLTDDDVTTDHYTQVVWATSYLIGCGMSSCHKGIHYLYICHYCHEGNDPDKKNVPYNKGSPCGDCPNNCEDKLCTNPCIYYDEYNNCNTQTQRLGCNHLSVQRLCKASCMCQTEIK", "length": 247, "header": "tr|E1BC47-1|E1BC47_BOVIN Isoform 1 of Cysteine rich secretory protein 1 OS=Bos taurus OX=9913 GN=CRISP1 PE=3 SV=1 CANONICAL=E1BC47-1" }, "locus": { "chromosome": "23", "start_pos": 22544257, "end_pos": 22527789, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010633.5", "url": "https://www.ensembl.org/id/ENSBTAT00000010633.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010633.4", "url": "https://www.ensembl.org/id/ENSBTAP00000010633.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616774", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616774", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D0I5J9-1", "protein_name": "Cysteine rich secretory protein 1", "gene_name": "CRISP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTMKRFLFLAVASGFLPVLIVQAKPAQVPYKTLLTELATVQEEIVTVHNTFRRGVSPPASNMLKMNWSEEAAQNARMLSKDCEFVESNALKRRITNTFCGENRYLTTDPVSWSNVIRIWYSEFKYFKYGEWTLTDDDVTVEHYTQIVWATSYLIGCGLASCGKGKSAHYLYICHYCHEGNDPNKKNEPYRRGTPCGDCPDYCEDKLCTNPCLYYDEYSNCKAQTRGPGCSHVSVQQLCKASCLCHTEIK", "length": 249 }, "evidence": [ { "id": "E1BC47", "url": "https://omabrowser.org/oma/group/E1BC47/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P54107-1", "protein_name": "Cysteine-rich secretory protein 1", "gene_name": "CRISP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEIKHLLFLVAAACLLPMLSMKKKSARDQFNKLVTDLPNVQEEIVNIHNALRRRVVPPASNMLKMSWSEEAAQNARIFSKYCDMTESNPLERRLPNTFCGENMHMTSYPVSWSSVIGVWYSESTSFKHGEWTTTDDDITTDHYTQIVWATSYLIGCAIASCRQQGSPRYLYVCHYCHEGNDPETKNEPYKTGVPCEACPSNCEDKLCTNPCIYYDEYFDCDIQVHYLGCNHSTTILFCKATCLCDTEIK", "length": 249 }, "evidence": [ { "id": "E1BC47", "url": "https://omabrowser.org/oma/group/E1BC47/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1BC47", "url": "https://www.uniprot.org/uniprotkb/E1BC47" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BC47", "url": "https://www.uniprot.org/uniprotkb/E1BC47" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BC47-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 247, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BC47-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BC47" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BC47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC47" }, { "id": "PS51670", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51670" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ShKT", "eco_id": "ECO_0000259", "start_pos": 209, "end_pos": 242, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 66, "end_pos": 68 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BB01-1", "uniprot_ac": "E1BB01", "uniprot_id": "E1BB01_BOVIN", "mass": { "chemical_mass": 21722.0, "monoisotopic_mass": 21722.0 }, "refseq": {}, "gene_names": [ { "name": "MAFK", "type": "recommended", "evidence": [ { "id": "E1BB01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB01" } ] } ], "protein_names": [ { "name": "MAF bZIP transcription factor K", "type": "synonym", "evidence": [ { "id": "E1BB01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB01/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BB01", "url": "https://www.uniprot.org/uniprotkb/E1BB01" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAFK", "url": "https://www.uniprot.org/uniprotkb/E1BB01", "locus": { "chromosome": "25", "start_pos": 41405570, "end_pos": 41424658, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019303", "url": "https://www.ensembl.org/id/ENSBTAG00000019303" } ] } } ], "crossref": [ { "id": "E1BB01", "url": "https://alphafold.ebi.ac.uk/entry/E1BB01", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019303", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019303", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14717", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14717", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR004826", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004826", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008917", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008917", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024874", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024874", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BB01", "url": "https://www.orthodb.org/?gene=E1BB01", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10129", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10129", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10129:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10129:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03131", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03131", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9707616", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9707616", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9708530", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9708530", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983231", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SGL9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGL9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB01", "url": "https://www.uniprot.org/uniprotkb/E1BB01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB01-1", "url": "https://www.uniprot.org/uniprotkb/E1BB01-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGCSRLSTSGDCCRHRAARAAPAVTATISRWFCPGDCAQVMTTNPKANKALKVKKEAGENAAALSDDELVSMSVRELNQHLRGLTREEVVRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRLELDALRSKYEALQTFARTVARGPVTPTKVATTSVITIVKSAEMAASASVPFSAAS", "length": 197, "header": "tr|E1BB01-1|E1BB01_BOVIN Isoform 1 of MAF bZIP transcription factor K OS=Bos taurus OX=9913 GN=MAFK PE=3 SV=3 CANONICAL=E1BB01-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGL9-1", "url": "https://www.uniprot.org/uniprotkb/E1BB01/entry#A0AAA9SGL9-1", "sequence": { "sequence": "MHCSATISRWFCPGDCAQVMTTNPKANKALKVKKEAGENAAALSDDELVSMSVRELNQHLRGLTREEVVRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRLELDALRSKYEALQTFARTVARGPVTPTKVATTSVITIVKSAEMAASASVPFSAAS", "length": 176, "header": "tr|A0AAA9SGL9-1|E1BB01_BOVIN Computationally mapped isoform of MAF bZIP transcription factor K OS=Bos taurus OX=9913 GN=MAFK PE=3 SV=1 CANONICAL=E1BB01-1" }, "locus": { "chromosome": "25", "start_pos": 41412440, "end_pos": 41406110, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102228.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102228.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081643.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081643.1" } ] } }, { "isoform_ac": "E1BB01-1", "url": "https://www.uniprot.org/uniprotkb/E1BB01/entry#E1BB01-1", "sequence": { "sequence": "MGCSRLSTSGDCCRHRAARAAPAVTATISRWFCPGDCAQVMTTNPKANKALKVKKEAGENAAALSDDELVSMSVRELNQHLRGLTREEVVRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRLELDALRSKYEALQTFARTVARGPVTPTKVATTSVITIVKSAEMAASASVPFSAAS", "length": 197, "header": "tr|E1BB01-1|E1BB01_BOVIN Isoform 1 of MAF bZIP transcription factor K OS=Bos taurus OX=9913 GN=MAFK PE=3 SV=3 CANONICAL=E1BB01-1" }, "locus": { "chromosome": "25", "start_pos": 41414967, "end_pos": 41406110, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025702.3", "url": "https://www.ensembl.org/id/ENSBTAT00000025702.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025702.3", "url": "https://www.ensembl.org/id/ENSBTAP00000025702.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9707616", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9707616", "resource": "Reactome", "description": 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"" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "E1BB01", "url": "https://www.uniprot.org/uniprotkb/E1BB01" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BB01", "url": "https://www.uniprot.org/uniprotkb/E1BB01" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BB01", "url": "https://www.uniprot.org/uniprotkb/E1BB01" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": 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Computationally mapped isoform of Methyl-CpG binding domain protein 6 OS=Bos taurus OX=9913 GN=MBD6 PE=4 SV=1 CANONICAL=E1BBH8-1" }, "locus": { "chromosome": "5", "start_pos": 55952787, "end_pos": 55947938, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100329.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100329.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081794.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081794.1" } ] } }, { "isoform_ac": "E1BBH8-1", "url": "https://www.uniprot.org/uniprotkb/E1BBH8/entry#E1BBH8-1", "sequence": { "sequence": 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"length": 1007, "header": "tr|E1BBH8-1|E1BBH8_BOVIN Isoform 1 of Methyl-CpG binding domain protein 6 OS=Bos taurus OX=9913 GN=MBD6 PE=4 SV=2 CANONICAL=E1BBH8-1" }, "locus": { "chromosome": "5", "start_pos": 55952787, "end_pos": 55947938, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014034.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014034.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014034.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014034.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 399, "start_aa": "Thr", "end_pos": 399, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr399", "evidence": [ { "id": "", "database": 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"database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 83, "start_aa": "Thr", "end_pos": 83, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr83", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:783807", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783807", "resource": "KEGG Pathway" }, { "id": "R-BTA-5689603", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689603", "resource": "Reactome", "description": "UCH proteinases" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZCX1-1", "protein_name": "Methyl-CpG binding domain protein 6", "gene_name": "Mbd6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNGGNESSAADRAGGPAATAVPIGWQRCVREGAVYYISPSGTELSSLEQTRSYLLSDGTCKCGLECPLNVPKVFNFDPLAPVTPGGAGVGPASEEDMTKLCNHRRKAVAMATLYRSMETTCSHSSPGEGASPQMFHTVSPGPASVRPSCRVPPTTPLNGGPGSIPQEPPSVPQAFPPLTGPAGLFPPRLPDPVPSAGSSSPCFLPRGNAPSPAPPPPSAISLNAPSYNWGASLRSNLVPSDLGSPPAPHASSSPPSDSPLFHCSDALTPPPVPPSNNLPGPPGPPGSTTQPPVSSATMHLPLVLGSLGGGPTVEGPGAPPFLASSLLSAAAKAQQPQLPPPSTLQGRRPRAQAPSASHASPRPSQRRPRRPPTVLRLLEGGGPQSPRRSRPRAPAPVPQPFPLPEPSQPILPSVLSLLGLPTPGPSHSDGSFNLLGSDAHLPPPPALSSGSPPQPRHPIQPSLPGTTSGSLSSVPGAPAPPAASKAPVVPSPVLQSPCDKGLGLGAGPACPLPPLAGEEAFPFPSPEQGLALSGAGFPGMLGALPLPLSLGQPPPSPLLSHSLFGVLAGAGQPPPEPLLPPPGGPGPPLAPGEPEGPSLLVASLLSPPPSDLLPPPAPPSNLLASFLPLLALGPTAGDGEGSAEGAGGPNGEPFSGLGDLPPLLFPPLSAPPTLIALNSALLAASLDPPSGTPPQPCVLSAPQPGPPTSSVTTATTDPGASSLGKAPSNSGRPPQLLICGGGGPDCNFSTGDLSSLTSSPGTLPSLLQPPGPLLSSQLGLQLLPGGGAPPTLSEASSPLACLLQSLQIPPEQPDAPCLPPESPASALEPEPARPPLSALAPPHGSPDPPVPELLTGRGSGKRGRRGGGGLRGINGETRPGRGRKPGSRREPGRLALKWGTRGGFNGQMERSPRRTHHWQHNGELAEGGAEPKDPPLPGPHPEDLKVSPGIVRKSRRGRRRKYNPARNSSSSSRQDVTLEPSPTTRAAVPLPPRARPGRPAKNKRRKLAP", "length": 1009 }, "evidence": [ { "id": "E1BBH8", "url": "https://omabrowser.org/oma/group/E1BBH8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3TY92-1", "protein_name": "Methyl-CpG-binding domain protein 6", "gene_name": "Mbd6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNGDNASSAADRAGGPAATPVPIPIGWQRCVREGAVYYISPSGTELSSLEQTRSYLLSDGTCKCGLECPLNVPKVFNFDPLAPVTPGGAGVGPASEEDMTKLCNHRRKAVAMATLYRSMETTCSHSSPGEGASPQMFHTVSPGPPSVRPPCRAPPTTPLNGGPGSIPQDPPSVPQAFPPLTGPAGLFPPPRLPDPVPSAGSSSPCFLPRGNAPSPAPPPPPAISLNAPSYNWGASLRSNLVPSDLGSPPAPHASSSPPSDSPLFHCSDALTSPPLPPSNNPPGPPGPPGPATQPPVSSATMHLPLVLGSLGGAPAVEGPGAPPFLASSLLSAAAKAQLPPPSTLQGRRPRAQAPSAAHASPRPSQRRPRRPPTVLRLLEGGGPQTPRRTRPRAPAPVPQPFPLPEPSQPILPSVLSLLGLPTPGPSHSDGSFNLLGSDAHLPPPPALSSGSPPQPRHPIQPSLPGTTSGSLSSVPGAPAPPAASKAPVVPSPVLQSPSDGLGMGAGPACPLPPLAGGEAFPFPSPEQGLALSGAGFPGMLGALPLPLSLGQPPPSPFLSHSLFGVLAGGGQPPPEPLLPPPGGPGPPSAPGEPEGPSLLVASLLSPPPSDLLPPPSAPPSNLLASFLPLLALGPTAGDGEGSAEGAGGPNGEPFSGLGDLPPLLFPPLSAPPTLIALNSALLAASLDPPSGTPPQPCVLSAPQPGPPTSSVTTATTDPGASSLGKAPSNSGRPQLLSPLLSASLLGDLSSLASSPGALPSLLQPPGPLLSSQLGLQLLPGGGAPPALSEASSPLACLLQSLQIPPEQPDAPCLPPESPASALEPEPARPPLSALAPPHASPDPPVPELLTGRGSGKRGRRGGGGLRGINGETRPGRGRKPGSRREPGRLALKWGTRGGFNGQMERSPRRTHHWQHNGELAEGGAEPKDPPLPGTHSEDLKVPPGIVRKSRRGRRRKYNPARNSSSSRQDVTLEPSPTTRAAVPLPPRARPGRPAKNKRRKLAP", "length": 1003 }, "evidence": [ { "id": "E1BBH8", "url": "https://omabrowser.org/oma/group/E1BBH8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96DN6-1", "protein_name": "Methyl-CpG-binding domain protein 6", "gene_name": "MBD6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNGGNESSGADRAGGPVATSVPIGWQRCVREGAVLYISPSGTELSSLEQTRSYLLSDGTCKCGLECPLNVPKVFNFDPLAPVTPGGAGVGPASEEDMTKLCNHRRKAVAMATLYRSMETTCSHSSPGEGASPQMFHTVSPGPPSARPPCRVPPTTPLNGGPGSLPPEPPSVSQAFPTLAGPGGLFPPRLADPVPSGGSSSPRFLPRGNAPSPAPPPPPAISLNAPSYNWGAALRSSLVPSDLGSPPAPHASSSPPSDPPLFHCSDALTPPPLPPSNNLPAHPGPASQPPVSSATMHLPLVLGPLGGAPTVEGPGAPPFLASSLLSAAAKAQHPPLPPPSTLQGRRPRAQAPSASHSSSLRPSQRRPRRPPTVFRLLEGRGPQTPRRSRPRAPAPVPQPFSLPEPSQPILPSVLSLLGLPTPGPSHSDGSFNLLGSDAHLPPPPTLSSGSPPQPRHPIQPSLPGTTSGSLSSVPGAPAPPAASKAPVVPSPVLQSPSEGLGMGAGPACPLPPLAGGEAFPFPSPEQGLALSGAGFPGMLGALPLPLSLGQPPPSPLLNHSLFGVLTGGGGQPPPEPLLPPPGGPGPPLAPGEPEGPSLLVASLLPPPPSDLLPPPSAPPSNLLASFLPLLALGPTAGDGEGSAEGAGGPSGEPFSGLGDLSPLLFPPLSAPPTLIALNSALLAATLDPPSGTPPQPCVLSAPQPGPPTSSVTTATTDPGASSLGKAPSNSGRPPQLLSPLLGASLLGDLSSLTSSPGALPSLLQPPGPLLSGQLGLQLLPGGGAPPPLSEASSPLACLLQSLQIPPEQPEAPCLPPESPASALEPEPARPPLSALAPPHGSPDPPVPELLTGRGSGKRGRRGGGGLRGINGEARPARGRKPGSRREPGRLALKWGTRGGFNGQMERSPRRTHHWQHNGELAEGGAEPKDPPPPGPHSEDLKVPPGVVRKSRRGRRRKYNPTRNSNSSRQDITLEPSPTARAAVPLPPRARPGRPAKNKRRKLAP", "length": 1003 }, "evidence": [ { "id": "E1BBH8", "url": "https://omabrowser.org/oma/group/E1BBH8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BBH8", "url": "https://www.uniprot.org/uniprotkb/E1BBH8" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "E1BBH8", "url": "https://www.uniprot.org/uniprotkb/E1BBH8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BBH8", "url": "https://www.uniprot.org/uniprotkb/E1BBH8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BBH8", "url": "https://www.uniprot.org/uniprotkb/E1BBH8" } ], "pmid": "" }, { "name": "chromocenter", "id": "GO:0010369", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010369", "evidence": [ { "database": "UniProtKB", "id": "E1BBH8", "url": "https://www.uniprot.org/uniprotkb/E1BBH8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 968, "end_pos": 970, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBH8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1007, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBH8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBH8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBH8" }, { "id": "PS50982", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50982" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MBD", "eco_id": "ECO_0000259", "start_pos": 11, "end_pos": 81, "start_aa": "Asp", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 83, 399, 638, 695 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 }, { "start_pos": 968, "end_pos": 970 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B9T4-1", "uniprot_ac": "E1B9T4", "uniprot_id": "E1B9T4_BOVIN", "mass": { "chemical_mass": 53765.0, "monoisotopic_mass": 53765.0 }, "refseq": { "ac": "XP_002698211", "name": "archaemetzincin-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698211" }, "gene_names": [ { "name": "AMZ1", "type": "recommended", "evidence": [ { "id": "E1B9T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9T4" } ] }, { "name": "AMZ1", "type": "synonym", "evidence": [ { "id": "XP_002698211", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698211" } ] } ], "protein_names": [ { "name": "Archaelysin family metallopeptidase 1", "type": "synonym", "evidence": [ { "id": "E1B9T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9T4/entry#names_and_taxonomy" } ] }, { "name": "archaemetzincin-1", "type": "synonym", "evidence": [ { "id": "XP_002698211", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698211" } ] } ], "function": [ { "annotation": "Probable zinc metalloprotease.", "evidence": [ { "database": "UniProtKB", "id": "E1B9T4", "url": "https://www.uniprot.org/uniprotkb/E1B9T4#function" }, { "database": "UniProtKB", "id": "ARBA00024316", "url": "https://www.uniprot.org/uniprotkb/ARBA00024316#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9T4", "url": "https://www.uniprot.org/uniprotkb/E1B9T4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AMZ1", "url": "https://www.uniprot.org/uniprotkb/E1B9T4", "locus": { "chromosome": "25", "start_pos": 40636132, "end_pos": 40651687, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026194", "url": "https://www.ensembl.org/id/ENSBTAG00000026194" } ] } } ], "crossref": [ { "id": "E1B9T4", "url": "https://alphafold.ebi.ac.uk/entry/E1B9T4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000026194", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026194", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11375", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11375", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "789913", "url": "https://www.ncbi.nlm.nih.gov/gene/789913", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012962", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012962", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:789913", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789913", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LAKWEMF", "url": "https://omabrowser.org/oma/group/LAKWEMF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B9T4", "url": "https://www.orthodb.org/?gene=E1B9T4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32205", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32205", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32205:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32205:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_002698211", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698211", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SHN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9T4", "url": "https://www.uniprot.org/uniprotkb/E1B9T4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9T4-1", "url": "https://www.uniprot.org/uniprotkb/E1B9T4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLQCRPAEEFSFGPRALKDALLSTDPALRQLYTAAFSPAERLFLAEAYNPRRTLFGTLLIRTAFDWLLSRPEAPEDFQTFHAALPPRKQSLARKHIYLQPIGLSEGPAGSVLLDQLRSCTEAFFLGLQVRCLPSVAAASIHCSSRPGQDPDRLQLHTDGILSFLKSSKPGDALCVLGLTLSDLYPCEAWTFTFGTFLPGHEVGVCSFARFSGEFLPRGPSTPDLVEVEAEAAADGPEVPLQDGGQAVCFSALGMVQCCKVTCHELCHLLGLGNCRWLRCLMQGALRVDEALRRPLDLCPICLRKLQHLLGFRLVDRYKRLYAWTQAAAGTQPSPAAVGEPSVSEDTLPCSADSGLCCESDSEPGSSLSEPLSPDAWIPAGLELDAEDGLGSLAAAEGPGEALAEHGRWLAACIQALERDVSEGELERVDGAVDALAPWDLFTGRLPASRQDLPCGRDGAGLRRVLGDTFSSLRRRLSARRPSRAESPLRRQKAEDD", "length": 496, "header": "tr|E1B9T4-1|E1B9T4_BOVIN Isoform 1 of Archaelysin family metallopeptidase 1 OS=Bos taurus OX=9913 GN=AMZ1 PE=3 SV=3 CANONICAL=E1B9T4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SHN4-1", "url": "https://www.uniprot.org/uniprotkb/E1B9T4/entry#A0AAA9SHN4-1", "sequence": { "sequence": "MLQCRPAEEFSFGPRALKDALLSTDPALRQLYTAAFSPAERLFLAEAYNPRRTLFGTLLIRTAFDWLLSRPEAPEDFQTFHAALPPRKQSLARKHIYLQPIGLSEGPAGSVLLDQLRSCTEAFFLGLQVRCLPSVAAASIHCSSRPGQDPDRLQLHTDGILSFLKSSKPGDALCVLGLTLSDLYPCEAWTFTFGTFLPGHGHVPRAVSPPGPGKLPLAPVPHAGRAARGRGPAPAPGPLPHLPAQAAAPAGLQAGGQVQETLRLDTSGSRDAAEPSGGGGTVCVGGHPSLQCRLGAVL", "length": 298, "header": "tr|A0AAA9SHN4-1|E1B9T4_BOVIN Computationally mapped isoform of Archaelysin family metallopeptidase 1 OS=Bos taurus OX=9913 GN=AMZ1 PE=3 SV=1 CANONICAL=E1B9T4-1" }, "locus": { "chromosome": "25", "start_pos": 40644215, "end_pos": 40637465, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127436.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127436.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083244.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083244.1" } ] } }, { "isoform_ac": "E1B9T4-1", "url": "https://www.uniprot.org/uniprotkb/E1B9T4/entry#E1B9T4-1", "sequence": { "sequence": "MLQCRPAEEFSFGPRALKDALLSTDPALRQLYTAAFSPAERLFLAEAYNPRRTLFGTLLIRTAFDWLLSRPEAPEDFQTFHAALPPRKQSLARKHIYLQPIGLSEGPAGSVLLDQLRSCTEAFFLGLQVRCLPSVAAASIHCSSRPGQDPDRLQLHTDGILSFLKSSKPGDALCVLGLTLSDLYPCEAWTFTFGTFLPGHEVGVCSFARFSGEFLPRGPSTPDLVEVEAEAAADGPEVPLQDGGQAVCFSALGMVQCCKVTCHELCHLLGLGNCRWLRCLMQGALRVDEALRRPLDLCPICLRKLQHLLGFRLVDRYKRLYAWTQAAAGTQPSPAAVGEPSVSEDTLPCSADSGLCCESDSEPGSSLSEPLSPDAWIPAGLELDAEDGLGSLAAAEGPGEALAEHGRWLAACIQALERDVSEGELERVDGAVDALAPWDLFTGRLPASRQDLPCGRDGAGLRRVLGDTFSSLRRRLSARRPSRAESPLRRQKAEDD", "length": 496, "header": "tr|E1B9T4-1|E1B9T4_BOVIN Isoform 1 of Archaelysin family metallopeptidase 1 OS=Bos taurus OX=9913 GN=AMZ1 PE=3 SV=3 CANONICAL=E1B9T4-1" }, "locus": { "chromosome": "25", "start_pos": 40644215, "end_pos": 40637047, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037103.5", "url": "https://www.ensembl.org/id/ENSBTAT00000037103.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036942.4", "url": "https://www.ensembl.org/id/ENSBTAP00000036942.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:789913", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789913", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QFK7-1", "protein_name": "Archaelysin family metallopeptidase 1", "gene_name": "AMZ1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLQCRPAQEFSFGPRALKDALVSTDPGLRQLYAAAFSPAERLFLAEAYNPRRTLFGAPRIHTAFDWLLSRPEAPEDFETFHAALPPRKQSPARKHIYLQPIDLSEGLAGGALLYHLRSCTEAFFLGLQVRCLPSVAAASIHCSSRLSQDSDRLQLHTDGILSFLKSSKPGDACVLGLTLSDLYPCEAWTFTFGKFLPGHEVGVCSFARFSEEFLQLGPSAPDVALAEVAADGPEVPLQDTGQTVCFSALGMLQCCKVTCHELCHLLGLGSCRWLRCLMQGALSLDEALRRPLDLCPICLRKLQHILGFRLVDRYKRLYLWTQAVAGTQTGEEAAGEPSASVSEDTLPCSADSGLCCESDSEPGTSLSEPLSPDAWSHAFPAGAELEPEDGLGALAAAEGPGEALAEHGRWLAACIQALERAVTEEELARVDSAVDALARWEMFTGQLPAPRHDLPCGQDSAGLRRILGGTFSSLRRRLSARRLARAEVSPRRGKAEEN", "length": 498 }, "evidence": [ { "id": "E1B9T4", "url": "https://omabrowser.org/oma/group/E1B9T4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2LYL6-1", "protein_name": "Archaemetzincin-1", "gene_name": "Amz1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLQCRPPQEFSFGPRALKDALISRDLALKQLYTSAFSPSERLFLSEAYNPHRTLFSTLLIHSAFDWLLSRPEAPEDFETFHASLQPRKQSLARKHIYLQPIDLSEGLAGCPLLDHLRNCAEAFFLGLRVKCLPSVAAASIHCSSRPSQDTDGLQLHTDGILSFLKNNKPGDALCVLGLTLADLYPHDAWTFTFGRFLPGHEVGVCSFARFSGEFLQAGPSLPDPALLEAAADDPETLPHEGGRTLCFSALGMVQCCKVTCHELCHLLGLGSCRWLRCLLQGALSLDEAIRRPLDLCPICLRKLQHLLGFRLLERYKRLHTWTRVMVEMWSGQEAGEPSVSDDTLPFSADSGMGCESDTEPVTSPSEPVTPDAWSHVFPDGPEPGSEDGLSSLVASEVLLKLGGPIEAIEEYGQWLGACIQVLEREVAEEELVHVDAAVDAMGRWEMFTGQLPVTRQHLPCVKDNVGLRRVLGDKFFSLRRRLSSRRLAKASSSHCRWGAEN", "length": 501 }, "evidence": [ { "id": "E1B9T4", "url": "https://omabrowser.org/oma/group/E1B9T4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0ZCN5-1", "protein_name": "Archaelysin family metallopeptidase 2", "gene_name": "AMZ2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLQCKHTQEFSFGPRALKDALISTNPALQELYAKAFSRAEKLFLSEAYNPQRTLFCTLLIRTAFDWLLSHPDAPEDFETFYHAMLRRKQSFCRKHIYLQPIDLTEGPAGPSLLDSLQSCVESFFLGLRVKCLPSIPISSIHCCYRHSRDSDRVQLHADGILNFLKNNKPMDALCVLGLTLTDLYPCETWSFTFSKFLPGQEVGVCSFARFSGDFPQASCSSLNPLTHREQLSDVSKESRERTLPFSAQEMVQCCKVTCHEICHLMGLGTCRWLQCIMQGALSLDEALLRPLEPCPICLRKLQHIVGFKLVERYRKLYAWTQTVLSTWPKQEPADLSASEDVLPLSSDSGMCCENDSEAVTSLSEPLTPDVCSQALSIGPELEQDERSCSLAEVQSQPQPAGPSQPTDVIKDYELWLEMCIAALERNVSEEELARVDKAVDALARWDMFTGQLPAMKKDLPFVRDNTGLRKVLGDKFSSLRRKLSSRKLSKGESSPHRWRWEDN", "length": 503 }, "evidence": [ { "id": "E1B9T4", "url": "https://omabrowser.org/oma/group/E1B9T4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q400C9-1", "protein_name": "Archaemetzincin-1", "gene_name": "Amz1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVQCRPPQEFSFGPRALKDALISCDLALKQLYTSAFSPSERLFLSEAYNPHRTLFSTLLIHSAFDWLLSRPEAPEDFETFHASLQLRKQSLARKHIYLQPIDLSEGLAGCPLLDHLRSCAEAFFLGLRVKCLPSVASASINCCSRPARDTDGLQLHTDGILSFLKNNKPGDALCVLGLTLADLYPHDAWTFTFGRFLPGHEVGVCSFARFSGEFLQAGSSIPDSALLEAAAGGPETLPQEGGQTLCYSALGMVQCCKVTCHELCHLLGLGSCRWLRCLLQGVLSLDEALRRPLDLCPICLRKLHHLLGFRLLERYKRLHTWTRVMLEMWSGQEAGEPSVSEDTLPFSADSGMGCESDTEPVTSPSEPVTPDAWSHTFPDGPEPVSEEGLSSLAASEVLLKLGGPVDALEEYRQWLDACIQALEREVAEEELVQVDAAVDALGRWEMFTGQLPVTKQYMPCVKDNVGLRRVLGDKFSSLRRRLSSRRLAKASSSQCHWGAEN", "length": 501 }, "evidence": [ { "id": "E1B9T4", "url": "https://omabrowser.org/oma/group/E1B9T4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q400G9-1", "protein_name": "Archaemetzincin-1", "gene_name": "AMZ1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLIRTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPIDLSEEPVGSSLLHQLCSCTEAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGLTLSDLYPHEAWSFTFSKFLPGHEVGVCSFARFSGEFPKSGPSAPDLALVEAAADGPEAPLQDRGWALCFSALGMVQCCKVTCHELCHLLGLGNCRWLRCLMQGALSLDEALRRPLDLCPICLRKLQHVLGFRLIERYQRLYTWTQAVVGTWPSQEAGEPSVWEDTPPASADSGMCCESDSEPGTSVSEPLTPDAGSHTFASGPEEGLSYLAASEAPLPPGGPAEAIKEHERWLAMCIQALQREVAEEDLVQVDRAVDALDRWEMFTGQLPATRQDPPSSRDSVGLRKVLGDKFSSLRRKLSARKLARAESAPRPWDGEES", "length": 498 }, "evidence": [ { "id": "E1B9T4", "url": "https://omabrowser.org/oma/group/E1B9T4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BVF9-1", "protein_name": "Archaemetzincin-1", "gene_name": "Amz1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVQCKPPQEFSFGPRALKDALISCDLALKQMYTSAFSPSERLFLSEAYNPNRTLFSTLLIHSAYDWLLSRPEAPEDFETFHASLQLRKQSLARKHIYLQPIDLSEGLAGCPLLDHLRSCAEAFFLGLRVKCLPSVAAASINCCSRPSRDTDGLQLHTDGILSFLKNNKPGDALCVLGLTLADLYPHDAWTFTFGRFLPGHEVGVCSFARFSGEFLQAGSSVPDSALLEAAAAGGPETLPRERGRTLCFSALGMVQCCKVTCHELCHLLGLGSCRWLRCLLQGALSLDEVLRRPLDLCPICLRKLHHLLGFRLLERYKRLHAWTRVMVEIWSGQEAGEPSVSEDTLPFSADSGMGCESDTEPVTSPSEPVTPDGWSHPFPDGPEPVSEDGLGSLMASEVSLTLGGPVDAMEEYGQWLTACIQTLEREGAEEELLQVDAAVDALSRWEMFTGQLPVTKQHVPCGKDNVGLRRVLGDKFSSLRRRLSSRRFAKASSSHCRWGAEN", "length": 502 }, "evidence": [ { "id": "E1B9T4", "url": "https://omabrowser.org/oma/group/E1B9T4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metallopeptidase activity", "id": "GO:0008237", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008237", "evidence": [ { "database": "UniProtKB", "id": "E1B9T4", "url": "https://www.uniprot.org/uniprotkb/E1B9T4" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1B9T4", "url": "https://www.uniprot.org/uniprotkb/E1B9T4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1B9T4", "url": "https://www.uniprot.org/uniprotkb/E1B9T4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9T4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 496, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9T4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9T4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B965-1", "uniprot_ac": "E1B965", "uniprot_id": "E1B965_BOVIN", "mass": { "chemical_mass": 101514.0, "monoisotopic_mass": 101514.0 }, "refseq": { "ac": "XP_003587709", "name": "metabotropic glutamate receptor 4 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587709" }, "gene_names": [ { "name": "GRM4", "type": "recommended", "evidence": [ { "id": "E1B965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B965" } ] }, { "name": "GRM4", "type": "synonym", "evidence": [ { "id": "XP_003587709", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587709" } ] } ], "protein_names": [ { "name": "Glutamate metabotropic receptor 4", "type": "synonym", "evidence": [ { "id": "E1B965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B965/entry#names_and_taxonomy" } ] }, { "name": "metabotropic glutamate receptor 4 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_003587709", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587709" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B965", "url": "https://www.uniprot.org/uniprotkb/E1B965" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GRM4", "url": "https://www.uniprot.org/uniprotkb/E1B965", "locus": { "chromosome": "23", "start_pos": 8140125, "end_pos": 8244159, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013632", "url": "https://www.ensembl.org/id/ENSBTAG00000013632" } ] } } ], "crossref": [ { "id": "E1B965", "url": "https://alphafold.ebi.ac.uk/entry/E1B965", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013632", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013632", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06376", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06376", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15452", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15452", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "790333", "url": "https://www.ncbi.nlm.nih.gov/gene/790333", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017978", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017978", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038550", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038550", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050726", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050726", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:790333", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:790333", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24060", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24060", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00003", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00003", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01094", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01094", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07562", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07562", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-420499", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420499", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_003587709", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587709", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SIF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIF4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0X9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0X9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0X9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0X9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B965", "url": "https://www.uniprot.org/uniprotkb/E1B965", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B965-1", "url": "https://www.uniprot.org/uniprotkb/E1B965-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"MPGKRGWGWWWAQLPLCLLLSLSGPWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGESGVEAFMQKSREDGGVCIAQSVKIPREPKPGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARKANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNGSAEYKVIGSWTDHLHLRIERMLWPGSGQQLPRSVCSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDGYTCKACPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVAGIAATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGSFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI", "length": 912, "header": "tr|E1B965-1|E1B965_BOVIN Isoform 1 of Glutamate metabotropic receptor 4 OS=Bos taurus OX=9913 GN=GRM4 PE=3 SV=4 CANONICAL=E1B965-1" }, "locus": { "chromosome": "23", "start_pos": 8243960, "end_pos": 8141037, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018119.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018119.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018119.7", "url": "https://www.ensembl.org/id/ENSBTAP00000018119.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:790333", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:790333", "resource": "KEGG Pathway" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" }, { "id": "R-BTA-420499", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420499", "resource": "Reactome", "description": "Class 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"UniProtKB", "id": "E1BDC4", "url": "https://www.uniprot.org/uniprotkb/E1BDC4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AKNA", "url": "https://www.uniprot.org/uniprotkb/E1BDC4", "locus": { "chromosome": "8", "start_pos": 103556445, "end_pos": 103604450, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017306", "url": "https://www.ensembl.org/id/ENSBTAG00000017306" } ] } } ], "crossref": [ { "id": "ENSBTAG00000017306", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017306", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539274", "url": "https://www.ncbi.nlm.nih.gov/gene/539274", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR022150", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022150", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052655", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052655", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539274", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539274", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PHLAMTE", "url": "https://omabrowser.org/oma/group/PHLAMTE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BDC4", "url": "https://www.orthodb.org/?gene=E1BDC4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21510", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21510", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21510:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21510:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12443", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12443", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024852115", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852115", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SIZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDC4", "url": "https://www.uniprot.org/uniprotkb/E1BDC4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDC4-1", "url": "https://www.uniprot.org/uniprotkb/E1BDC4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASSGTEVHWVEPGLGKGPQRRRWAWAEKGKDADESGTRSSEEEGPFPTASSPELLEDFRQAQQCLQPLKWGQDSQPAGCQDPESGESSEAESEEEDEDSPESSNLPLSWLPQQDPQSDMTKEDPSEALQGPEVQEAGESSPRLGYETYLSSGGHGSTSPTTLDWGQPAGWVASSKQASGDKLPEHSEVNPTADFSSPRSWSSGTVSLNHPSDNLDSTWEGETDVPQPTALAETSPQSPSHHLLNPNDRTEGSVALATPTEFQGSSAPLAQSLQCPADRWRAENSSLSCPQPGGQSWKQTRTSPKPLPSRFTGSISPPNPSPRPARQDRPPPRPGATLAGHSSSDAPKYGRGRLNYPLPDFSKVGPRVKFPKDESYHPPKARSHSRLPEGPAKPLIFKSPAEIVREVLLSSGDVCPGKNPPPTHPITRVPQEFQTPEQATKLVHQLQEDYHKLLTKYAEAENTIDQLRLGAKVNLYSDPPQPSHSIHTGTMPQGTKVLSFTIPQPHSVKWYVGPAEGPQASEASGSPSAGGDPRPSSPSSMPTPGWLQEDAGGIAQDQPSVEQAQELASQASRFLTKVESFIELIHAGWLTPQDQLKVFQQLKAAHAALEEDYLKACREWHLSQQLAGSKGTPRRFDPDREVEAEIFQLGIRLDELKDLMDHNEQEPGQVGSDLALDSPPATPSPHQPTDLPSPLEQTRTSAIQTLGPEPDATSTGPHLLPMNSDLSAPSNEAEDGPLGLPAPLRHKELRVEQDFHGLLERYLSVKSLPEALRMEEEEAEGQGRTLGFDRPDPAPGKAVAPRLPTRQPPAQAERSHGVPLEETMEQMAPVKPADVCASVTRDGHLQGLGKAEEVPPGHSRPPHPRGPKSATSHQSSLASLEGSGISERLPPKSLHQAGGPPLEEPWMASPETDSGFVGSETSRVSPLTQTPEHRLSQISTPGTLVRSFTLPVPQDAASHRQTKGLPVPRRTSEPSGPRSRAQRPPSGQDSPLQQRAPSFCLERALASEMAVPGSEFKGRKRIPEPILPSATISPPPTPAPVAATPPRGPAEITSTFFLTRTGRDQAIRELQDEVSRLRLRLEDSLHQHPQGRPTRSVSSCDRPTRARERSGDSSAAWSSHYVSKSMERSSGEPGGAEQAVPAGRRRARSSSVPREEPRLSLSSESEPASPRLFSERGRTTENSPQAARDGTKGVSSTGRPNRVTFRGQYTGQEYYVLTPKTVPRSSVPVSCPHCRPPRMEDPGDAVTRDPLGPSGSETLRCPLCSQVGSPSEGDGPDSATSAPEKAATSRNAPSTSSPKQRSKRAGSPPRPPPGLWYLAVAPSAPAPPAFAYISSVPVLPYPSATVYYAPPAPTSAPSVRAAAEWPPAACSRPARGSRHSVQLDLKDLEELNKALSRAVEAAESVRSTTQHMSRSLSAELRQARSLRGSCLF", "length": 1432, "header": "tr|E1BDC4-1|E1BDC4_BOVIN Isoform 1 of AT-hook transcription factor OS=Bos taurus OX=9913 GN=AKNA PE=4 SV=3 CANONICAL=E1BDC4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIZ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BDC4/entry#A0AAA9SIZ1-1", "sequence": { "sequence": "MSAAGGARSHPTTSPGTTSQAIRELQDEVSRLRLRLEDSLHQHPQGRPTRSVSSCDRPTRARERSGDSSAAWSSHYVSKSMERSSGEPGGAEQAVPAGRRRARSSSVPREEPRLSLSSESEPASPRLFSERGRTTENSPQAARDGTKGVSSTGRPNRVTFRGQYTGQEYYVLTPKTVPRSSVPVSCPHCRPPRMEDPGDAVTRDPLGPSGSETLRCPLCSQVGSPSEGDGPDSATSAPEKAATSRNAPSTSSPKQRSKRAGSPPRPPPGLWYLAVAPSAPAPPAFAYISSVPVLPYPSATVYYAPPAPTSAPSVRAAAEWPPAACSRPARGSRHSVQLDLKDLEELNKALSRAVEAAESVRSTTQHMSRSLSAELRQARSLRGSCLF", "length": 387, "header": "tr|A0AAA9SIZ1-1|E1BDC4_BOVIN Computationally mapped isoform of AT-hook transcription factor OS=Bos taurus OX=9913 GN=AKNA PE=4 SV=1 CANONICAL=E1BDC4-1" }, "locus": { "chromosome": "8", "start_pos": 103568401, "end_pos": 103557449, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120454.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120454.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083766.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083766.1" } ] } }, { "isoform_ac": "E1BDC4-1", "url": "https://www.uniprot.org/uniprotkb/E1BDC4/entry#E1BDC4-1", "sequence": { "sequence": "MASSGTEVHWVEPGLGKGPQRRRWAWAEKGKDADESGTRSSEEEGPFPTASSPELLEDFRQAQQCLQPLKWGQDSQPAGCQDPESGESSEAESEEEDEDSPESSNLPLSWLPQQDPQSDMTKEDPSEALQGPEVQEAGESSPRLGYETYLSSGGHGSTSPTTLDWGQPAGWVASSKQASGDKLPEHSEVNPTADFSSPRSWSSGTVSLNHPSDNLDSTWEGETDVPQPTALAETSPQSPSHHLLNPNDRTEGSVALATPTEFQGSSAPLAQSLQCPADRWRAENSSLSCPQPGGQSWKQTRTSPKPLPSRFTGSISPPNPSPRPARQDRPPPRPGATLAGHSSSDAPKYGRGRLNYPLPDFSKVGPRVKFPKDESYHPPKARSHSRLPEGPAKPLIFKSPAEIVREVLLSSGDVCPGKNPPPTHPITRVPQEFQTPEQATKLVHQLQEDYHKLLTKYAEAENTIDQLRLGAKVNLYSDPPQPSHSIHTGTMPQGTKVLSFTIPQPHSVKWYVGPAEGPQASEASGSPSAGGDPRPSSPSSMPTPGWLQEDAGGIAQDQPSVEQAQELASQASRFLTKVESFIELIHAGWLTPQDQLKVFQQLKAAHAALEEDYLKACREWHLSQQLAGSKGTPRRFDPDREVEAEIFQLGIRLDELKDLMDHNEQEPGQVGSDLALDSPPATPSPHQPTDLPSPLEQTRTSAIQTLGPEPDATSTGPHLLPMNSDLSAPSNEAEDGPLGLPAPLRHKELRVEQDFHGLLERYLSVKSLPEALRMEEEEAEGQGRTLGFDRPDPAPGKAVAPRLPTRQPPAQAERSHGVPLEETMEQMAPVKPADVCASVTRDGHLQGLGKAEEVPPGHSRPPHPRGPKSATSHQSSLASLEGSGISERLPPKSLHQAGGPPLEEPWMASPETDSGFVGSETSRVSPLTQTPEHRLSQISTPGTLVRSFTLPVPQDAASHRQTKGLPVPRRTSEPSGPRSRAQRPPSGQDSPLQQRAPSFCLERALASEMAVPGSEFKGRKRIPEPILPSATISPPPTPAPVAATPPRGPAEITSTFFLTRTGRDQAIRELQDEVSRLRLRLEDSLHQHPQGRPTRSVSSCDRPTRARERSGDSSAAWSSHYVSKSMERSSGEPGGAEQAVPAGRRRARSSSVPREEPRLSLSSESEPASPRLFSERGRTTENSPQAARDGTKGVSSTGRPNRVTFRGQYTGQEYYVLTPKTVPRSSVPVSCPHCRPPRMEDPGDAVTRDPLGPSGSETLRCPLCSQVGSPSEGDGPDSATSAPEKAATSRNAPSTSSPKQRSKRAGSPPRPPPGLWYLAVAPSAPAPPAFAYISSVPVLPYPSATVYYAPPAPTSAPSVRAAAEWPPAACSRPARGSRHSVQLDLKDLEELNKALSRAVEAAESVRSTTQHMSRSLSAELRQARSLRGSCLF", "length": 1432, "header": "tr|E1BDC4-1|E1BDC4_BOVIN Isoform 1 of AT-hook transcription factor OS=Bos taurus OX=9913 GN=AKNA PE=4 SV=3 CANONICAL=E1BDC4-1" }, "locus": { "chromosome": "8", "start_pos": 103598256, "end_pos": 103557449, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023012.7", "url": "https://www.ensembl.org/id/ENSBTAT00000023012.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023012.6", "url": "https://www.ensembl.org/id/ENSBTAP00000023012.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1037, "start_aa": "Thr", "end_pos": 1037, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1037", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1044, "start_aa": "Thr", "end_pos": 1044, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1044", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1354, "start_aa": "Thr", "end_pos": 1354, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1354", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 49, "start_aa": "Thr", "end_pos": 49, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr49", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 543, "start_aa": "Thr", "end_pos": 543, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr543", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 682, "start_aa": "Thr", "end_pos": 682, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr682", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539274", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539274", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AFZ7-1", "protein_name": "AT-hook transcription factor", "gene_name": "AKNA", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGSSSPWLRWTQSELGSQEPKCWEEEEEEDDEEEDFERHMDENGVIGLGAAAAELSDPQDSGSEWGQEAAGSPIWGDGEDLDVGSPAEPCWYAQQDLTEEEEEEEEEQGSSEEDERPEGPWGTESDGDPHAETPLKAPGTTTDGGGTSGPSDSSPVPTTPPRQRRGWGRARDPNQSPQTPQQPKPSWLSPSPRRRTDTKKPKDPTDICPYGRGRLNHPLPDLSKVEARVKVGQSYRPPPSRALPARSRPHGGPLVPKSPAEIVREVLLSSGEGAPPRPSAPPGVPQELRSPRQATALVQQLQDDYHKLLTKYAEAENTIDQLRLGAKVNLYADPPCASRSAHAGTMSGGCRVMAFSIPRASAAAISTAPNPQLPVGGAPAPQPAEHGRASSQPCSPRSPLGGCPTCVGPCCCAGPRLTQTLAEQTRKFQAQVDSFEAWIRAGSSVPQEQLQWFQRLRDTQDALERAYLEAREEQSLGDTGNFDPERTVEGDIFCLGMRLEELKERLERAAPGSPAVTEGLPGTGETVGDSGAVGLPRPLRHKQLQAEEDFGDLLQQYQRLKSLPASLSLEQLSLTGSAALEEAGGTAAGDNGPGGVLSGAQSLEEGTDLETSPSPPPQRKAVPLPHAEPPHPQGTHGRLSPVTTSLPPTTSRLPLAFPEPLPSRAAPSRHSSGAGSTATQRRALKPCHQEQRMVSPETDSGFIGSESSRVSLLARTPERRPLGSGMRGVLEPPVPAPVHPQKKEAPLLPPRKALRGPYPTPGHGPPPGNSVPPSTPSPSSSPVRWAGSQGSELGPEGDGGHSDSEGGDRSCTSGHPPSGTPASPSPALVHCDLLGSRMERDRAIRALQDEVWRLRLRLEESLHRSHSYPEGRAPHTPKGRRQPAASRASFLQDSAPVGEHSPTARGRATAGGSRGRWASLPRDGTPPDLTSRSDRSPRARGDSRPGAAPSAHKRPRSPPGAASLRGQQAAERREPEPVGTAHGRADTASAGAQHRVAPPRGEPSAAPCPRCHPDRTAAGAPSVDATRPQHSSTPRSPERCPTCRAPRGDADRAAHAQRSTDGATPPEPRGRPQAVQPEQPAGCWYLAGGPPVAYLAPVPVVPYAPSLLYRPPAAPTSAPHHSRSPPLSDLEEDLDRSLSAAVAAARRARVTSRRLGRVLAAELGRARAVRGSCLF", "length": 1175 }, "evidence": [ { "id": "E1BDC4", "url": "https://omabrowser.org/oma/group/E1BDC4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZLV5-1", "protein_name": "AT-hook transcription factor", "gene_name": "Akna", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASSGTKAQWAGSNLGQGPRRRRWAWAEEQDADGRGDQGWRNKQSLPEAITPELLEDFRQAQEHLPPLEWDPDMQGSEESSAEDTEADDVSSPEGSPVPLPWLSRHSQRLGLSDEELDETPGSPEVDLAGESSTELECEDQGDLSPPVAGQEPARGWVASIKQGSNYRPSEHPEAQPSVEHSRTKSWSNATMGLGQPSDSLGSTWEGDTDVPQPDTLPEALPQSPCHNLLHPDDRNEGDVAPATPTEFRHSLAAPARNPERSAGTWGRETTSLPSSRPEDQSWKRTKASPKPLPSRFTGSVSPLSTRLGAVNKVVSQHKQGATVAGHSSSRVPKYGRGRLNYPLPDFSKVGPRVRFPKDENYRPPKSRGHNRQQGSTRPLIFKSPAEIVRDVLLSSGDTPLAKESSLAHPVTRVPQEFQTPEQATELVHQLQEDYHKLLTKYAEAENTIDQLRLGAKVHLYSDPPQPSQSFCSGSMPQGSKVLSFSIPQPRSAEWWPDPAQDSQASEATGWPFPRTDLSPSSSPSMATPGRPHQSQGIAVDQPSTGQIQALTSQASRLLAKVESFEELVLAGHLPPQDQIKSLEQLRAAHMALEAEYVQACGEEHLDPQLDASQGSPRTLNLCRELEAEIYQLGQRLEELQDHIDQTRAEPEPCGTDLQDSTPTIPFQPQPAHLPMPSGPVPPPDVQTYQEPVTTTTSPGNSCMLPMPKEVNLGIRTEGSPRGLLVPLKDRKLQAEQDFHGLLERYLSVKSLPEALRVEDEEDPEEEEEQQDHPDTLKVDGSTAAPGKTEARRASPGQHPAQAEERHRAAIQEDKEQMVSMKSSNFQPSMARNRYTPVLDTAGVAQGGTKPMPSHQSSLTSLEESRPSDLLPRKALLRAGGPHTEEPWMVSPETDSGFVGSETSIVSPFTQTPEHQISHISTPGPSAQHLTVSAPGDGTSHPKVKGPVVPRRATEAGIPRSLTQRHHSSLSSLRRGAQSCHLEETPVAKIAVPRSEFKRQKQISKQHLPSGTTSPDSAPAPTAASMPHGSAESTANLLLTRTERDQAIKDLQAEVSRLRLQLEDSLHRPRPDSPACVAPAFNCSTQTQKKLVDSSPSWGSRYGSKSTERLFGEPSGAEPAEPMGRRQVRSSSVPRDVPRLSSSESESPAPRLSSEKNRTFEEHPQAAQWGTRPLGSTKRRERVSFWGQYTGQEYHILSPKTNLKDSGTASCPHCQPIRTQDTGNAVSREPLGSSAADTLRCSLCGGVKPSAEADGPSPAPSEKNTPQKPAPSTPSLKRKKRQTDSPVRMLPGLWYLAAAPPAPAPPALAYISAPIMPYPPPTVYYATPAPTSVHTASPQPAQGPRRTRHSVQLGLNDLEELQAALREAARAAENVRSTTRQLSHSLSADLRHARSLRGSCLF", "length": 1402 }, "evidence": [ { "id": "E1BDC4", "url": "https://omabrowser.org/oma/group/E1BDC4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7Z591-1", "protein_name": "Microtubule organization protein AKNA", "gene_name": "AKNA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASSETEIRWAEPGLGKGPQRRRWAWAEDKRDVDRSSSQSWEEERLFPNATSPELLEDFRLAQQHLPPLEWDPHPQPDGHQDSESGETSGEEAEAEDVDSPASSHEPLAWLPQQGRQLDMTEEEPDGTLGSLEVEEAGESSSRLGYEAGLSLEGHGNTSPMALGHGQARGWVASGEQASGDKLSEHSEVNPSVELSPARSWSSGTVSLDHPSDSLDSTWEGETDGPQPTALAETLPEGPSHHLLSPDGRTGGSVARATPMEFQDSSAPPAQSPQHATDRWRRETTRFFCPQPKEHIWKQTKTSPKPLPSRFIGSISPLNPQPRPTRQGRPLPRQGATLAGRSSSNAPKYGRGQLNYPLPDFSKVGPRVRFPKDESYRPPKSRSHNRKPQAPARPLIFKSPAEIVQEVLLSSGEAALAKDTPPAHPITRVPQEFQTPEQATELVHQLQEDYHRLLTKYAEAENTIDQLRLGAKVNLFSDPPQPNHSIHTGMVPQGTKVLSFTIPQPRSAEWWPGPAEDPQASAASGWPSARGDLSPSSLTSMPTLGWLPENRDISEDQSSAEQTQALASQASQFLAKVESFERLIQAGRLMPQDQVKGFQRLKAAHAALEEEYLKACREQHPAQPLAGSKGTPGRFDPRRELEAEIYRLGSCLEELKEHIDQTQQEPEPPGSDSALDSTPALPCLHQPTHLPAPSGQAPMPAIKTSCPEPATTTAAASTGPCPLHVNVEVSSGNSEVEDRPQDPLARLRHKELQMEQVYHGLMERYLSVKSLPEAMRMEEEEEGEEEEEEEGGGDSLEVDGVAATPGKAEATRVLPRQCPVQAEKSHGAPLEEATEKMVSMKPPGFQASLARDGHMSGLGKAEAAPPGPGVPPHPPGTKSAASHQSSMTSLEGSGISERLPQKPLHRGGGPHLEETWMASPETDSGFVGSETSRVSPLTQTPEHRLSHISTAGTLAQPFAASVPRDGASYPKARGSLIPRRATEPSTPRSQAQRYLSSPSGPLRQRAPNFSLERTLAAEMAVPGSEFEGHKRISEQPLPNKTISPPPAPAPAAAPLPCGPTETIPSFLLTRAGRDQAICELQEEVSRLRLRLEDSLHQPLQGSPTRPASAFDRPARTRGRPADSPATWGSHYGSKSTERLPGEPRGEEQIVPPGRQRARSSSVPREVLRLSLSSESELPSLPLFSEKSKTTKDSPQAARDGKRGVGSAGWPDRVTFRGQYTGHEYHVLSPKAVPKGNGTVSCPHCRPIRTQDAGGAVTGDPLGPPPADTLQCPLCGQVGSPPEADGPGSATSGAEKATTRRKASSTPSPKQRSKQAGSSPRPPPGLWYLATAPPAPAPPAFAYISSVPIMPYPPAAVYYAPAGPTSAQPAAKWPPTASPPPARRHRHSIQLDLGDLEELNKALSRAVQAAESVRSTTRQMRSSLSADLRQAHSLRGSCLF", "length": 1439 }, "evidence": [ { "id": "E1BDC4", "url": "https://omabrowser.org/oma/group/E1BDC4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q80VW7-1", "protein_name": "Microtubule organization protein AKNA", "gene_name": "Akna", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASSGAKAQWVGPSLGQGPRRRRWAWAEEQDTDGRRDQGWGNSQSLPEAPSPELLEDFRRAQEHLPPLEWDPDMQDSEESSGEETEADDASSPEGSTVPLPWLSRSNQQLDMSEEELDEASGRPEVDLAGESCTELECEDQGDSSPPPPGQGPAKGWVTFIKQGSNYRPSEHLEAQPSVEHSRTKSWSSGTVSLRQPSDSLGSTWEGDTEVPQPSILPKALPQSPCHNFPHPGDRNGGDVAPATPTEFRDSLAAPAQNAECSAGTWGEETTSLPSSRPEDQTWKRTKTSPKPLPSRFTGSVSPLSTRLGAIKKVVPQHKQGATLAGHSSSQAPKYGRGRRLNYPLPDFSKVGPRVRFPKDENYRPPKSRGHNRQQGSTRPLIFKSPAEIVRDVLLSSGEASLAKESSLAHTITRVPQEFQTPEQATELVHQLQEDYHKLLTKYAEAENTIDQLRLGAKVHLYSDPPQPSQSFCSGSMPQGSKVLSFSIPQPRVAEWWPDPAQDPQASEATGWPFPRTDLSPSSSPGVATPGRLPQSQGIATDQPSTGQTQALTSQASRLLAKVQSFEELVLAGHLPPQDQIKSLEQLRAAHMALEAEYLQACREELLDPQLDASQGSPRTLNLCRELEAEIYHLGQRLEELQDHMDQTQRETEPCRPDLQDSTPTMSFLPQSAHLSMPSGPVSLPDGQTYQEPATTTTTSPGSSCTLPINKKLSLSIKTEESPRGLPVPLRDRTLQVEQDFHGLLERYLSVKSLPEALRDEDEDDLEEEEEEQDHQGPLEVDSPATAPGKTEAVRVPPGERPTQAEESHRDATQEDEEQMGPMKSPDFRPSMARDTYTPVLDTAEVAQRGTKAMVSHQSSLTSLEESRPSELLPRKALLRAGGPHTEEPWMVSPETDSGFVGSETSIVSPFTQTPEHRLSHVSTSGPSAQHLTASVPGDRTSHPKARGLMVPRRATETGIPRSRTQQHFSSLSSPGRGAQSCHLEETSVAKIAVPRSEFKRQKQISKQLLPSGRTSPDSAPAPTAASTPHGSAESTANLLLNRTERDQAIKDLQAEVSRLRLQLEDSLHRPHPDGPACVASAFNHSTQTQEKLGSSPSWGPHYGSKSTERLSREPNGVEPAEPMGRRRARSSSVPRDVPRLYLSSESESPAPRLSSEKSRTFEEHPEAAQWGTRPQSSSKRRERVSFRGQYTGQEYHILSPKAILKDSGTPSCPHCHPIRTQDTGSAVSRDTTRGSSAADTLRCALCGEVKSSAEADGSSSGPSEKNTPKKPSTPILKRKNRQTGSPVRMAPGLWYLAAAPPAPAPPALAYISSAPIMPYLPPTVYYAAPAPTSAQTASPQPARGPRRTRHSVQLGLNDLEELQAALREAAQAAENVRSTTRQLSRSLSADLRHARSLRGSCLF", "length": 1404 }, "evidence": [ { "id": "E1BDC4", "url": "https://omabrowser.org/oma/group/E1BDC4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BDC4", "url": "https://www.uniprot.org/uniprotkb/E1BDC4" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "E1BDC4", "url": "https://www.uniprot.org/uniprotkb/E1BDC4" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "E1BDC4", "url": "https://www.uniprot.org/uniprotkb/E1BDC4" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "E1BDC4", "url": "https://www.uniprot.org/uniprotkb/E1BDC4" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "E1BDC4", "url": "https://www.uniprot.org/uniprotkb/E1BDC4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "E1BDC4", "url": "https://www.uniprot.org/uniprotkb/E1BDC4" } ], "pmid": "" }, { "name": "regulation of inflammatory response", "id": "GO:0050727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050727", "evidence": [ { "database": "UniProtKB", "id": "E1BDC4", "url": "https://www.uniprot.org/uniprotkb/E1BDC4" } ], "pmid": "" }, { "name": "epithelial to mesenchymal transition", "id": "GO:0001837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001837", "evidence": [ { "database": "UniProtKB", "id": "E1BDC4", "url": "https://www.uniprot.org/uniprotkb/E1BDC4" } ], "pmid": "" }, { "name": "neuroblast division in subventricular zone", "id": "GO:0021849", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021849", "evidence": [ { "database": "UniProtKB", "id": "E1BDC4", "url": "https://www.uniprot.org/uniprotkb/E1BDC4" } ], "pmid": "" }, { "name": "neuroblast delamination", "id": "GO:0060234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060234", "evidence": [ { "database": "UniProtKB", "id": "E1BDC4", "url": "https://www.uniprot.org/uniprotkb/E1BDC4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 284, "end_pos": 286, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDC4" }, { "id": "PF12443", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12443" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AKNA", "eco_id": "ECO_0000259", "start_pos": 599, "end_pos": 697, "start_aa": "Phe", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 49, 543, 682, 1037, 1044, 1354 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 284, "end_pos": 286 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 6 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 6 }, { "field": "exact_o_linked_sites", "count": 6 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 6 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 6 }, { "field": "exact_o_linked_sites", "count": 6 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BAT8-1", "uniprot_ac": "E1BAT8", "uniprot_id": "E1BAT8_BOVIN", "mass": { "chemical_mass": 212581.0, "monoisotopic_mass": 212581.0 }, "refseq": { "ac": "XP_005225419", "name": "kinesin-like protein KIF20B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225419" }, "gene_names": [ { "name": "KIF20B", "type": "recommended", "evidence": [ { "id": "E1BAT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ] }, { "name": "LOC782598", "type": "recommended", "evidence": [ { "id": "E1BAT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ] }, { "name": "KIF20B", "type": "synonym", "evidence": [ { "id": "XP_005225419", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225419" } ] }, { "name": "LOC782598", "type": "synonym", "evidence": [ { "id": "E1BAT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ] }, { "name": "MPHOSPH1", "type": "synonym", "evidence": [ { "id": "XP_005225419", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225419" } ] } ], "protein_names": [ { "name": "Kinesin family member 20B", "type": "synonym", "evidence": [ { "id": "E1BAT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAT8/entry#names_and_taxonomy" } ] }, { "name": "kinesin-like protein KIF20B isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005225419", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225419" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KIF20B", "url": "https://www.uniprot.org/uniprotkb/E1BAT8", "locus": { "chromosome": "26", "start_pos": 11435642, "end_pos": 11351677, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005708", "url": "https://www.ensembl.org/id/ENSBTAG00000005708" } ] } } ], "crossref": [ { "id": "ENSBTAG00000005708", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005708", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01368", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01368", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21786", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21786", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514679", "url": "https://www.ncbi.nlm.nih.gov/gene/514679", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BAT8", "url": "https://www.orthodb.org/?gene=E1BAT8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47970", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47970", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47970:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47970:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00225", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00225", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005225419", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225419", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SJB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJB4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAT8-1", "url": "https://www.uniprot.org/uniprotkb/E1BAT8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"length": 1836, "header": "tr|E1BAT8-1|E1BAT8_BOVIN Isoform 1 of Kinesin family member 20B OS=Bos taurus OX=9913 GN=KIF20B PE=3 SV=2 CANONICAL=E1BAT8-1" }, "locus": { "chromosome": "26", "start_pos": 11435467, "end_pos": 11351777, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032984.6", "url": "https://www.ensembl.org/id/ENSBTAT00000032984.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032911.4", "url": "https://www.ensembl.org/id/ENSBTAP00000032911.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "microtubule motor activity", "id": "GO:0003777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003777", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "WW domain binding", "id": "GO:0050699", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050699", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "plus-end-directed microtubule motor activity", "id": "GO:0008574", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008574", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 14, "go_terms": [ { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "kinesin complex", "id": "GO:0005871", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005871", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "contractile ring", "id": "GO:0070938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070938", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "mitotic spindle pole", "id": "GO:0097431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097431", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "mitotic spindle midzone", "id": "GO:1990023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990023", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "microtubule-based movement", "id": "GO:0007018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007018", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "positive regulation of mitotic cytokinetic process", "id": "GO:1903438", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903438", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "positive regulation of intracellular protein transport", "id": "GO:0090316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090316", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "neuron projection morphogenesis", "id": "GO:0048812", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048812", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "regulation of establishment of cell polarity", "id": "GO:2000114", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000114", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "protein localization to microtubule", "id": "GO:0035372", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035372", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" }, { "name": "positive regulation of neuron migration", "id": "GO:2001224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001224", "evidence": [ { "database": "UniProtKB", "id": "E1BAT8", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1440, "end_pos": 1442, "annotation": 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990, "annotation": "n_glycosylation_sequon" }, { "start_pos": 992, "end_pos": 994, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAT8" }, { "id": "PS50067", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50067" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kinesin motor", "eco_id": "ECO_0000259", "start_pos": 66, "end_pos": 488, "start_aa": "Tyr", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1440, "end_pos": 1442 }, { "start_pos": 1630, "end_pos": 1632 }, { "start_pos": 1690, "end_pos": 1692 }, { "start_pos": 1736, "end_pos": 1738 }, { "start_pos": 1785, "end_pos": 1787 }, { "start_pos": 239, "end_pos": 241 }, { "start_pos": 355, "end_pos": 357 }, { "start_pos": 413, "end_pos": 415 }, { "start_pos": 464, "end_pos": 466 }, { "start_pos": 495, "end_pos": 497 }, { "start_pos": 516, "end_pos": 518 }, { "start_pos": 59, "end_pos": 61 }, { "start_pos": 816, "end_pos": 818 }, { "start_pos": 988, "end_pos": 990 }, { "start_pos": 992, "end_pos": 994 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { 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"https://www.uniprot.org/uniprotkb/E1BDA9" } ] } ], "protein_names": [ { "name": "TSPO associated protein 1", "type": "synonym", "evidence": [ { "id": "E1BDA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDA9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDA9", "url": "https://www.uniprot.org/uniprotkb/E1BDA9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSPOAP1", "url": "https://www.uniprot.org/uniprotkb/E1BDA9", "locus": { "chromosome": "19", "start_pos": 9272533, "end_pos": 9297960, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046321", "url": "https://www.ensembl.org/id/ENSBTAG00000046321" } ] } } ], "crossref": [ { "id": "E1BDA9", "url": "https://alphafold.ebi.ac.uk/entry/E1BDA9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046321", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046321", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12012", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12012", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12013", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12013", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12014", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12014", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035753", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035753", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035755", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035755", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040325", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040325", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057950", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057950", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BDA9", "url": "https://www.orthodb.org/?gene=E1BDA9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14234", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14234", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14234:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14234:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14604", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14604", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25523", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25523", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25566", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25566", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SN96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDA9", "url": "https://www.uniprot.org/uniprotkb/E1BDA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDA9-1", "url": "https://www.uniprot.org/uniprotkb/E1BDA9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQLTSLPSLGDPGNMERWALPAWQSWTPGRGGDAGGASPSMAGTPTDLRVGELRPEESSEPEGARSPGPVGGMEPGRTGTGLPSPARGALSSGPGCQRLEDPEAEAFSKGKLKMGFGDRPNLELLRAMGELQQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPMPSPGASLELCRKTLARQRARDLSETASALLAKDKQIAALQRECRELQARLTLAGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQREPPSPPRPPGPSVPARAGAPAPGAPGEATPQEDVENPAVVLGEPEKQQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLKAAQNENARLVEENSRLSGRATEKEKVEWENAELRGQLLGVTQERDSALLKSQGLQSKLESLEQVLKHMREVTQRRQQLEVEHEQARLSLQEKREEVRRLQQAQAEAQREHEGAVQLLESTLDSMQVRVRELEEQCRSQTERFSLLARELQAFRLHPGPLDLLTSALGCGAPGDSPPHPCCCSTPQPCRGSGPKDLDLPPASPGRCTPKSSETASATLAGVSRRTPAKRAESLSNSSRSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAVAEGGRGGARVQVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGSMDEDGFFEGELMDGRRGLVPSNFVERVSDDDLLASLPPELADLSHSSGPELSFLSGGGGGSSSGGQSSGGRSQPRPEDEAAGEVPSPSPPPEGLGEPPAVPYPRRLAVLKQLAHSVVLAWEPPPERVELCGYHVCVNGELRQALGSGAPPTAVLENLDLQAGPLRVSVQALTSRGGSDPLRCCLLLGARARVAPSQLRVHRLTATSAEIAWVPSNSSLAHAVYLNGEECLPARPSTYWATFCHLRPGTLYQARVEAQLPPRGSWEPGGERPEPRAATLQFTTLPAGPPDAPLDVQVEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYAVYADGQKIMEVASPTAGSVLVELAQLQLLQACRAVAVRTMSPHGESADSLPAPVPPALPEASWPARVPCACPRPGPEARPPLAPASPGLGDPSSHLRYPNPRGAQEPPGAPPASPPREMAGGSSEEPPAPVSQEQAGAAVLGASGDGKASEPVLGECVPGPATSSVAKEDTEQTAGEACLAPGTTQGALAQRLPCAQACRGGDAGSGLRPRAEEDAAELGVRPGNSLVDQGRNSDLSDIQEEEEEEEEELGVITRSFPKQVAGHSIGGQGAKPQPDPFCETDSDEEILEQILEPPLQHFRSKKLFSIPEEEEEEEEAEEEEEPGAGSASRDPGPPAPLPPGLGCDGARPRGPGLCASSPQPCRAGDRPEDPLGLVGGSSWRKGSGSPEKPPGRRRSPDLREHCSRLLSNGGGGSQAPGRAPGPARERGGPAAAEGPRAPPDAGGRARPAPSRKCPRGRAPEPEPGLASCLSPKCLEISIEYDSEDEQETGGGDMSIANSGCLGDGEAWGAAPVGRPRAPPKAGSGPHPYPYSPAWEKGEPERRGRSATGRAKEPPPRAAESGEPRGLESPGQSGSQRRRGWAPRPGSTELAPPRSPPEASLALRDLPVRVFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRWGYIPCNMVAEVAVDSPAGTQQLLQRGHLSPEVLAEGSGNGLFVYSAAHTAGPPPKPRRSKKAEWEGPAQPCAGPPALASSAGLKAPHSMVAAFDYNPRESSPNVDVEAELPFRAGDVITVFGAMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGSDREPGAAPSEGQRTRRRRVQC", "length": 1856, "header": "tr|E1BDA9-1|E1BDA9_BOVIN Isoform 1 of TSPO associated protein 1 OS=Bos taurus OX=9913 GN=TSPOAP1 PE=3 SV=4 CANONICAL=E1BDA9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SN96-1", "url": "https://www.uniprot.org/uniprotkb/E1BDA9/entry#A0AAA9SN96-1", "sequence": { "sequence": "MEQLTSLPSLGDPGNMERWALPAWQSWTPGRGGDAGGASPSMAGTPTDLRVGELRPEESSEPEGARSPGPVGGMEPGRTGTGLPSPARGALSSGPGCQRLEDPEAEAFSKGKLKMGFGDRPNLELLRAMGELQQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQREPPSPPRPPGPSVPARAGAPAPGAPGEATPQEDVENPAVVLGEPEKQQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLKAAQNENARLVEENSRLSGRATEKEKVEWENAELRGQLLGVTQERDSALLKSQGLQSKLESLEQVLKHMREVTQRRQQLEVEHEQARLSLQEKREEVRRLQQAQAEAQREHEGAVQLLESTLDSMQVRVRELEEQCRSQTERFSLLARELQAFRLHPGPLDLLTSALGCGAPGDSPPHPCCCSTPQPCRGSGPKDLDLPPASPGRCTPKSSETASATLAGVSRRTPAKRAESLSNSSRSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAVAEGGRGGARVQVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGSMDEDGFFEGELMDGRRGLVPSNFVERVSDDDLLASLPPELADLSHSSGPELSFLSGGGGGSSSGGQSSGGRSQPRPEDEAAGEVPSPSPPPEGLGEPPAVPYPRRLAVLKQLAHSVVLAWEPPPERVELCGYHVCVNGELRQALGSGAPPTAVLENLDLQAGPLRVSVQALTSRGGSDPLRCCLLLGARARVAPSQLRVHRLTATSAEIAWVPSNSSLAHAVYLNGEECLPARPSTYWATFCHLRPGTLYQARVEAQLPPRGSWEPGGERPEPRAATLQFTTLPAGPPDAPLDVQVEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYAVYADGQKIMEVASPTAGSVLVELAQLQLLQACRAVAVRTMSPHGESADSLPAPVPPALPEASWPARVPCACPRPGPEARPPLAPASPGLGDPSSHLRYPNPRGAQEPPGAPPASPPREMAGGSSEEPPAPVSQEQAGAAVLGASGDGKASEPVLGECVPGPATSSVAKEDTEQTAGEACLAPGTTQGALAQRLPCAQACRGGDAGSGLRPRAEEDAAELGVRPGNSLVDQGRNSDLSDIQEEEEEEEEELGVITRSFPKQVAGHSIGGQGAKPQPDPFCETDSDEEILEQILEPPLQHFRSKKLFSIPEEEEEEEEAEEEEEPGAGSASRDPGPPAPLPPGLGCDGARPRGPGLCASSPQPCRAGDRPEDPLGLVGGSSWRKGSGSPEKPPGRRRSPDLREHCSRLLSNGGGGSQAPGRAPGPARERGGPAAAEGPRAPPDAGGRARPAPSRKCPRGRAPEPEPGLASCLSPKCLEISIEYDSEDEQETGGGDMSIANSGCLGDGEAWGAAPVGRPRAPPKAGSGPHPYPYSPAWEKGEPERRGRSATGRAKEPPPRAAESGEPRGLESPGQSGSQRRRGWAPRPGSTELAPPRSPPEASLALRDLPVRVFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRWGYIPCNMVAEVAVDSPAGTQQLLQRGHLSPEVLAEGSGNGLFVYSAAHTAGPPPKPRRSKKAEWEGPAQPCAGPPALASSAGLKAPHSMVAAFDYNPRESSPNVDVEAELPFRAGDVITVFGAMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGSDREPGAAPSEGQRTRRRRVQC", "length": 1796, "header": "tr|A0AAA9SN96-1|E1BDA9_BOVIN Computationally mapped isoform of TSPO associated protein 1 OS=Bos taurus OX=9913 GN=TSPOAP1 PE=3 SV=1 CANONICAL=E1BDA9-1" }, "locus": { "chromosome": "19", "start_pos": 9297960, "end_pos": 9275475, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109078.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109078.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086807.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086807.1" } ] } }, { "isoform_ac": "E1BDA9-1", "url": "https://www.uniprot.org/uniprotkb/E1BDA9/entry#E1BDA9-1", "sequence": { "sequence": "MEQLTSLPSLGDPGNMERWALPAWQSWTPGRGGDAGGASPSMAGTPTDLRVGELRPEESSEPEGARSPGPVGGMEPGRTGTGLPSPARGALSSGPGCQRLEDPEAEAFSKGKLKMGFGDRPNLELLRAMGELQQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPMPSPGASLELCRKTLARQRARDLSETASALLAKDKQIAALQRECRELQARLTLAGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQREPPSPPRPPGPSVPARAGAPAPGAPGEATPQEDVENPAVVLGEPEKQQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLKAAQNENARLVEENSRLSGRATEKEKVEWENAELRGQLLGVTQERDSALLKSQGLQSKLESLEQVLKHMREVTQRRQQLEVEHEQARLSLQEKREEVRRLQQAQAEAQREHEGAVQLLESTLDSMQVRVRELEEQCRSQTERFSLLARELQAFRLHPGPLDLLTSALGCGAPGDSPPHPCCCSTPQPCRGSGPKDLDLPPASPGRCTPKSSETASATLAGVSRRTPAKRAESLSNSSRSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAVAEGGRGGARVQVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGSMDEDGFFEGELMDGRRGLVPSNFVERVSDDDLLASLPPELADLSHSSGPELSFLSGGGGGSSSGGQSSGGRSQPRPEDEAAGEVPSPSPPPEGLGEPPAVPYPRRLAVLKQLAHSVVLAWEPPPERVELCGYHVCVNGELRQALGSGAPPTAVLENLDLQAGPLRVSVQALTSRGGSDPLRCCLLLGARARVAPSQLRVHRLTATSAEIAWVPSNSSLAHAVYLNGEECLPARPSTYWATFCHLRPGTLYQARVEAQLPPRGSWEPGGERPEPRAATLQFTTLPAGPPDAPLDVQVEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYAVYADGQKIMEVASPTAGSVLVELAQLQLLQACRAVAVRTMSPHGESADSLPAPVPPALPEASWPARVPCACPRPGPEARPPLAPASPGLGDPSSHLRYPNPRGAQEPPGAPPASPPREMAGGSSEEPPAPVSQEQAGAAVLGASGDGKASEPVLGECVPGPATSSVAKEDTEQTAGEACLAPGTTQGALAQRLPCAQACRGGDAGSGLRPRAEEDAAELGVRPGNSLVDQGRNSDLSDIQEEEEEEEEELGVITRSFPKQVAGHSIGGQGAKPQPDPFCETDSDEEILEQILEPPLQHFRSKKLFSIPEEEEEEEEAEEEEEPGAGSASRDPGPPAPLPPGLGCDGARPRGPGLCASSPQPCRAGDRPEDPLGLVGGSSWRKGSGSPEKPPGRRRSPDLREHCSRLLSNGGGGSQAPGRAPGPARERGGPAAAEGPRAPPDAGGRARPAPSRKCPRGRAPEPEPGLASCLSPKCLEISIEYDSEDEQETGGGDMSIANSGCLGDGEAWGAAPVGRPRAPPKAGSGPHPYPYSPAWEKGEPERRGRSATGRAKEPPPRAAESGEPRGLESPGQSGSQRRRGWAPRPGSTELAPPRSPPEASLALRDLPVRVFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRWGYIPCNMVAEVAVDSPAGTQQLLQRGHLSPEVLAEGSGNGLFVYSAAHTAGPPPKPRRSKKAEWEGPAQPCAGPPALASSAGLKAPHSMVAAFDYNPRESSPNVDVEAELPFRAGDVITVFGAMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGSDREPGAAPSEGQRTRRRRVQC", "length": 1856, "header": "tr|E1BDA9-1|E1BDA9_BOVIN Isoform 1 of TSPO associated protein 1 OS=Bos taurus OX=9913 GN=TSPOAP1 PE=3 SV=4 CANONICAL=E1BDA9-1" }, "locus": { "chromosome": "19", "start_pos": 9297960, "end_pos": 9275475, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015433.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015433.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015433.7", "url": "https://www.ensembl.org/id/ENSBTAP00000015433.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1033, "start_aa": "Thr", "end_pos": 1033, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1033", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 620, "start_aa": "Thr", "end_pos": 620, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr620", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BDA9", "url": "https://www.uniprot.org/uniprotkb/E1BDA9" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "E1BDA9", "url": "https://www.uniprot.org/uniprotkb/E1BDA9" } ], "pmid": "" }, { "name": "calyx of Held", "id": "GO:0044305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044305", "evidence": [ { "database": "UniProtKB", "id": "E1BDA9", "url": "https://www.uniprot.org/uniprotkb/E1BDA9" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1BDA9", "url": "https://www.uniprot.org/uniprotkb/E1BDA9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of neurotransmitter secretion", "id": "GO:0046928", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046928", "evidence": [ { "database": "UniProtKB", "id": "E1BDA9", "url": "https://www.uniprot.org/uniprotkb/E1BDA9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "benzodiazepine receptor binding", "id": "GO:0030156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030156", "evidence": [ { "database": "UniProtKB", "id": "E1BDA9", "url": "https://www.uniprot.org/uniprotkb/E1BDA9" } ], "pmid": "" }, { "name": "voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels", "id": "GO:0099626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099626", "evidence": [ { "database": "UniProtKB", "id": "E1BDA9", "url": "https://www.uniprot.org/uniprotkb/E1BDA9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 604, "end_pos": 606, "annotation": "n_glycosylation_sequon" }, { "start_pos": 904, "end_pos": 906, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], 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"UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC2/entry#names_and_taxonomy" } ] }, { "name": "TSC22 domain family protein 2", "type": "synonym", "evidence": [ { "id": "NP_001137573", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137573" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCC2", "url": "https://www.uniprot.org/uniprotkb/E1BCC2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSC22D2", "url": "https://www.uniprot.org/uniprotkb/E1BCC2", "locus": { "chromosome": "1", "start_pos": 117672585, "end_pos": 117718237, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018402", "url": "https://www.ensembl.org/id/ENSBTAG00000018402" } ] } } ], "crossref": [ { "id": "E1BCC2", 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"bta:541277", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541277", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TFYQVFH", "url": "https://omabrowser.org/oma/group/TFYQVFH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCC2", "url": "https://www.orthodb.org/?gene=E1BCC2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46894", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46894", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46894:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46894:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01166", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01166", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001137573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137573", 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"MSKMPAKKKSCFQITSVTTAQVATSITEDTESLDDPDESRTEDVSSEIFDVSRATDYGPEEVCERSSSEETLNNVGDAETPGTVSPNLLLDGQLAAATAAPANGGGAISARSVAGVLASTLSPAATSVPSSGAPGAPPLTGPSATPGTAASSQPPTICSSRFRVIKLDHGSGEPYRRGRWTCMEYYERDSDSSVLTRSGDCIRHSNTFDQTAERDSGLGATGGSVVVVVASVPGAHGPDSGTDSSLTAVSQLPQSEKMSQPAPAPPQSFGVGQPQPPPPPVGGAVAPSSASLPLFPGAAAGPPQRLAAPPPSQAQGAGPPGPNGQGLPLTNVTLAQPGLAVGAATAPPPQQFAYSQPQMPPGHLLPVPPAAQSEYLQPHVAGLQPPSPAQPSSAGAAAGLAAVAGLPAGTGQNAASTGAQVMGAPSLPGEAVAPGPGPATGGPAAPGQQAGVPAAAVGGTAPSGLVPAGVGQPQAAPPPQMSGSGAPSVVPSGPLAVVPGVANVPAAAPAPSVPSVSTTSVTMPNVPAPLGQAPQLCSQPPVSRSGSSIQHVGLPLVPGTASAPTSLPQSDLSQFQTQTQPLVGQVDDTRRKSEPLPQPPLSLIAENKPVVKPPVADALANPLQLTPMNSLATSVFSIAIPVDGDEDRNPSTAFYQAFHLNTVQESKNLWDSASGGGGVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSNNDQLSQLPAQQANPGSTSQQQAVIAQPPQPTQPPQQPNVSSA", "length": 775, "header": "tr|E1BCC2-1|E1BCC2_BOVIN Isoform 1 of TSC22 domain family member 2 OS=Bos taurus OX=9913 GN=TSC22D2 PE=3 SV=1 CANONICAL=E1BCC2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQ96-1", "url": "https://www.uniprot.org/uniprotkb/E1BCC2/entry#A0AAA9SQ96-1", "sequence": { "sequence": "MSKMPAKKKSCFQITSVTTAQVATSITEDTESLDDPDESRTEDVSSEIFDVSRATDYGPEEVCERSSSEETLNNVGDAETPGTVSPNLLLDGQLAAATAAPANGGGAISARSVAGVLASTLSPAATSVPSSGAPGAPPLTGPSATPGTAASSQPPTICSSRFRVIKLDHGSGEPYRRGRWTCMEYYERDSDSSVLTRSGDCIRHSNTFDQTAERDSGLGATGGSVVVVVASVPGAHGPDSGTDSSLTAVSQLPQSEKMSQPAPAPPQSFGVGQPQPPPPPVGGAVAPSSASLPLFPGAAAGPPQRLAAPPPSQAQGAGPPGPNGQGLPLTNVTLAQPGLAVGAATAPPPQQFAYSQPQMPPGHLLPVPPAAQSEYLQPHVAGLQPPSPAQPSSAGAAAGLAAVAGLPAGTGQNAASTGAQVMGAPSLPGEAVAPGPGPATGGPAAPGQQAGVPAAAVGGTAPSGLVPAGVGQPQAAPPPQMSGSGAPSVVPSGPLAVVPGVANVPAAAPAPSVPSVSTTSVTMPNVPAPLGQAPQLCSQPPVSRSGSSIQHVGLPLVPGTASAPTSLPQSDLSQFQTQTQPLVGQVDDTRRKSEPLPQPPLSLIAENKPVVKPPVADALANPLQLTPMNSLATSVFSIAIPVDGDEDSASGGGGVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSNNDQLSQLPAQQANPGSTSQQQAVIAQPPQPTQPPQQPNVSSA", "length": 751, "header": "tr|A0AAA9SQ96-1|E1BCC2_BOVIN Computationally mapped isoform of TSC22 domain family member 2 OS=Bos taurus OX=9913 GN=TSC22D2 PE=3 SV=1 CANONICAL=E1BCC2-1" }, "locus": { "chromosome": "1", "start_pos": 117717595, "end_pos": 117674041, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098049.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098049.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087541.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087541.1" } ] } }, { "isoform_ac": "E1BCC2-1", "url": "https://www.uniprot.org/uniprotkb/E1BCC2/entry#E1BCC2-1", "sequence": { "sequence": "MSKMPAKKKSCFQITSVTTAQVATSITEDTESLDDPDESRTEDVSSEIFDVSRATDYGPEEVCERSSSEETLNNVGDAETPGTVSPNLLLDGQLAAATAAPANGGGAISARSVAGVLASTLSPAATSVPSSGAPGAPPLTGPSATPGTAASSQPPTICSSRFRVIKLDHGSGEPYRRGRWTCMEYYERDSDSSVLTRSGDCIRHSNTFDQTAERDSGLGATGGSVVVVVASVPGAHGPDSGTDSSLTAVSQLPQSEKMSQPAPAPPQSFGVGQPQPPPPPVGGAVAPSSASLPLFPGAAAGPPQRLAAPPPSQAQGAGPPGPNGQGLPLTNVTLAQPGLAVGAATAPPPQQFAYSQPQMPPGHLLPVPPAAQSEYLQPHVAGLQPPSPAQPSSAGAAAGLAAVAGLPAGTGQNAASTGAQVMGAPSLPGEAVAPGPGPATGGPAAPGQQAGVPAAAVGGTAPSGLVPAGVGQPQAAPPPQMSGSGAPSVVPSGPLAVVPGVANVPAAAPAPSVPSVSTTSVTMPNVPAPLGQAPQLCSQPPVSRSGSSIQHVGLPLVPGTASAPTSLPQSDLSQFQTQTQPLVGQVDDTRRKSEPLPQPPLSLIAENKPVVKPPVADALANPLQLTPMNSLATSVFSIAIPVDGDEDRNPSTAFYQAFHLNTVQESKNLWDSASGGGGVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSNNDQLSQLPAQQANPGSTSQQQAVIAQPPQPTQPPQQPNVSSA", "length": 775, "header": "tr|E1BCC2-1|E1BCC2_BOVIN Isoform 1 of TSC22 domain family member 2 OS=Bos taurus OX=9913 GN=TSC22D2 PE=3 SV=1 CANONICAL=E1BCC2-1" }, "locus": { "chromosome": "1", "start_pos": 117717595, "end_pos": 117674041, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024485.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024485.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024485.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024485.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 145, "start_aa": "Thr", "end_pos": 145, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr145", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 460, "start_aa": "Thr", "end_pos": 460, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr460", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 764, "start_aa": "Thr", "end_pos": 764, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr764", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:541277", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541277", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0X6N2-1", "protein_name": "TSC22 domain family member 2", "gene_name": "TSC22D2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSKMPAKKKSCFQITSVTTAQVASSITEDTESLDDPDESRTEDVSSEIFDVSRATDYGPEDVCERSSSEETLNNVGEAETPSSVSPNLLLDGQLAAAAGGGAAVPPAVAPNGGAVPKSSAVPLPAAGTGGSGAQPALPYSGPSAPAAPGTMAQTVAAACSSRFRVIKLDHGTGEPYRRGRWTCMEYYDRDSDGSGVLGRTGDCIRHSSTFEQAAQERDSGLGATGGSVVVSAVPASAHGPDSIADSSLTAVSQLLQTEKMNQASLQQPNFVIGQQQQSQQPIGGAMPQSTAQSMFSGASVANQQIMVPQQSQPQVNTQSVAQAGPNGKGIAPPSVTMGQTSIPVAQQQVQQASVPVTQPQQFAYSQSQIPPVHLLPTQPSGQSEYMQHMTIMQPQGAIQQAPAGSVPSTAASNLPVGQVTGPSPSPGGAPVMGVPAQPGEAVAQGSGIMQSGQTQAGQTAVQQPGGMVQQGIGHAGVVQQKSVTQHQMSGSSQVSGMPGAPHAVVSGVQNVPAVVPGTSVPSVSTTSVTMPNVPVTLVQSQLPSHTSVSRSTGVVQQQQQHVGHSLIQGAPNVPTNLPQSNLGQFQTPAQSVVGQIDDTRRKSEPLPQPPLSLTAEIKPLVKPPIPDTLANPLQLPASTPMNSLASSVFGISIPVDGDEDRPLLQSGKTFLNSIPAVLSACRSSAVVKIVCTPLSKSWIKVSHNRLRGDPGELFDASFPPADPLESHMNPSTAFYQAFHFNKLRESKTFWDSASGASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSNNDQLSQLSAQQANPSSTLQAQAVMAQPAQPAQPPQQPNVSSA", "length": 855 }, "evidence": [ { "id": "E1BCC2", "url": "https://omabrowser.org/oma/group/E1BCC2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZDW3-1", "protein_name": "TSC22 domain family, member 2", "gene_name": "Tsc22d2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSKMPAKKKSCFQITSVTTAQVATSITEDTESLDDPDESRTEDVSSEIFDVSRATDYGPEEVCERSSSEETLNNVGDAETPGTVSPNLILDGQLAAASAVPANGGGGVPARSVAGALSQTLAAVATSVSAPGPSSATPSQPPATCSSRFRVIKLDHGSGEPYRRGRWTCMEYYERDSDSSVLSRSGDCIRHSNTLEQTAERDSGLGATGGSVVVVVASMQGAHGLDSGTDSSLTAVSQLPPSEKMSQPTLAQPQSFSVGQPQPPPPVGGAVAPSSVSLPLFPGAATGSQPMTAATQPTQLQGAVAGGALPGPVGQGLPPPPNVNLAQPVALTAQPGPAVGSSLSQQFAYPQPPIPPGHLLPVQPSGQSEYLPPHVALQPPSPAQPLSTSASATSASAASFPLGSGQSVSSLGAQMMGASAQPSEVVAPGPVPVGQAAPCQPAGVAPAAIGGVVQPGSGLTGVGQPQSVQPPPHMGGSVQLSAVPGGPHTVVPGVPNVPAAVPVPSVPVVPTTSVTMPNVPAPLGQSQQLSGHTPVSRSSSVIQQVGPPLAQGTHSAPTSLPQSDLSQFQTQTQSLVRQIDDTRRKSEPLPQAPLSLIAENKPVVKPPVADALANPLQLTPMNSLATSVFSIAIPVDGDEDRNPSTAFYQAFHLNTFQESKSLWDSASGGGVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSNNDQLSQLPAQQANPGSTSQQQAMIAQPPQPTQPPQQPNVSSA", "length": 768 }, "evidence": [ { "id": "E1BCC2", "url": "https://omabrowser.org/oma/group/E1BCC2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9Q7M2-1", "protein_name": "TSC22 domain family protein 2", "gene_name": "Tsc22d2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSKMPAKKKSCFQITSVTTAQVATSITEDTESLDDPDESRTEDVSSEIFDVSRATDYGPEEVCERSSSEETLNNVGDAETPGTVSPNLILDGQLAAASAAPANGGGGGVSARSVAGALAQTLAAAAASVSTPGPSSATPSQPPATCSSRFRVIKLDHGSGEPYRRGRWTCMEYYERDSDSSVLTRSGDCIRHSNTLEQTAERDSGLGATGGSVVVVVASMQGAHGLDSGTDSSLTAVSQLPPSEKMSQPTLAQPQSFSVGQPQPPPPVGGAVAPSSASLPPFPGAATGPQPMTAAVQPTQLQGAVAGGALPGPVGQGLPPPPNVNLAQPVALAAQPGPAGGSSLSQQFAYPQPQIPPGHLLPMQPSGQSEYLPPHVALQPPSPAQPLSTSASATSASAASFPLGSGQSVSSLGAQMMGASAQPSEAVAPGPVPVGQAAPCQPAGVAPAALGGVVQPGSGLTGVGQPQPVQPPQQMGGSGQLPAVPGGPHTVVPGVPNVPAAVPVPSVPSVPTTSVTMPNVPAPLGQSQQLSSHTPVSRSSSVIQQVGSPLAQGTHSAPTSLPQSDLSQFQTQTQPLVGQVDDTRRKSEPLPQAPLSLIAESKPVVKPPVADALTNPLQLTPMNSLATSVFSIAIPVDGDEDRNPSTAFYQAFHLNTCQESKSLWDSASGGGVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSNNDQLSQLPAQQANPGSTSQQQAMIAQPPQPTQPPQQPNVSSA", "length": 769 }, "evidence": [ { "id": "E1BCC2", "url": "https://omabrowser.org/oma/group/E1BCC2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O75157-1", "protein_name": "TSC22 domain family protein 2", "gene_name": "TSC22D2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSKMPAKKKSCFQITSVTTAQVATSITEDTESLDDPDESRTEDVSSEIFDVSRATDYGPEEVCERSSSEETLNNVGDAETPGTVSPNLLLDGQLAAAAAAPANGGGVVSARSVSGALASTLAAAATSAPAPGAPGGPQLAGSSAGPVTAAPSQPPTTCSSRFRVIKLDHGSGEPYRRGRWTCMEYYERDSDSSVLTRSGDCIRHSSTFDQTAERDSGLGATGGSVVVVVASMQGAHGPESGTDSSLTAVSQLPPSEKMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIPPGHLLPVQPSGQSEYLQQHVAGLQPPSPAQPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGVPPATVGGVVQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLAQSQQLSSHTPVSRSSSIIQHVGLPLAPGTHSAPTSLPQSDLSQFQTQTQPLVGQVDDTRRKSEPLPQPPLSLIAENKPVVKPPVADSLANPLQLTPMNSLATSVFSIAIPVDGDEDRNPSTAFYQAFHLNTLKESKSLWDSASGGGVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSSNDQLSQLPTQQANPGSTSQQQAVIAQPPQPTQPPQQPNVSSA", "length": 780 }, "evidence": [ { "id": "E1BCC2", "url": "https://omabrowser.org/oma/group/E1BCC2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BCC2", "url": "https://www.uniprot.org/uniprotkb/E1BCC2" } ], "pmid": "" }, { "name": "negative regulation of cell cycle", "id": "GO:0045786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045786", "evidence": [ { "database": "UniProtKB", "id": "E1BCC2", "url": "https://www.uniprot.org/uniprotkb/E1BCC2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 331, "end_pos": 333, "annotation": "n_glycosylation_sequon" }, { "start_pos": 771, "end_pos": 773, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCC2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 775, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCC2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCC2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 145, 460, 764 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 331, "end_pos": 333 }, { "start_pos": 771, "end_pos": 773 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDD5-1", "uniprot_ac": "E1BDD5", "uniprot_id": "E1BDD5_BOVIN", "mass": { "chemical_mass": 127880.0, "monoisotopic_mass": 127880.0 }, "refseq": { "ac": "NP_001192519", "name": "integrin alpha-10 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192519" }, "gene_names": [ { "name": "ITGA10", "type": "recommended", "evidence": [ { "id": "E1BDD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDD5" } ] }, { "name": "ITGA10", "type": "synonym", "evidence": [ { "id": "NP_001192519", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192519" } ] } ], "protein_names": [ { "name": "Integrin subunit alpha 10", "type": "synonym", "evidence": [ { "id": "E1BDD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDD5/entry#names_and_taxonomy" } ] }, { "name": "integrin alpha-10 precursor", "type": "synonym", "evidence": [ { "id": "NP_001192519", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192519" } ] }, { "name": "integrin, alpha 10", "type": "synonym", "evidence": [ { "id": "NP_001192519", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192519" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDD5", "url": "https://www.uniprot.org/uniprotkb/E1BDD5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ITGA10", "url": "https://www.uniprot.org/uniprotkb/E1BDD5", "locus": { "chromosome": "3", "start_pos": 21477566, "end_pos": 21460349, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008373", "url": "https://www.ensembl.org/id/ENSBTAG00000008373" } ] } } ], "crossref": [ { "id": "E1BDD5", "url": "https://alphafold.ebi.ac.uk/entry/E1BDD5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008373", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008373", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01469", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01469", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506526", "url": "https://www.ncbi.nlm.nih.gov/gene/506526", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013517", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013517", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013649", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013649", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018184", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018184", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032695", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032695", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048285", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048285", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506526", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506526", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IVGAYDW", "url": "https://omabrowser.org/oma/group/IVGAYDW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BDD5", "url": "https://www.orthodb.org/?gene=E1BDD5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23220", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23220", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23220:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23220:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00092", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00092", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01839", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01839", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08441", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08441", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20805", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20805", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216083", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192519", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SRK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRK3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDD5", "url": "https://www.uniprot.org/uniprotkb/E1BDD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDD5-1", "url": "https://www.uniprot.org/uniprotkb/E1BDD5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEFPLIPHLFLPLMFLTGLCSSFNLDVHRPRLFLGPPEAEFGYSVLQHVGGGRQWMLVGAPWDGPSGDRRGDVYRCLVGGSHSAPCAKGHLGDHPLGNSSRPAVNMHLGMSLLETDGNGGFMACAPLWSRACGSSVFSSGICARVDASFRPQGSLAPTAQRCPTYMDVVIVLDGSNSIYPWSEVQTFLRRLVGRLFIDPEQIQVGLVQYGESSVHEWSLGDFRTKEEVVRAARNLSRREGRETKTAQAIMMACTEGFSQSRGGRPEAARLLVVVTDGESHDGEELPTALQACEAGRVTRYGIAVLGHYLRRQRDPSSFLREIRAIASDPDEKFFFNVTDEAALTDIVDALGDRIFGLEGSHGENESSFGLEMSQIGFSTHQLKDGILFGMVGAYDWGGSVLWLEEGRRLFPPRTALEDEFPPALQNHAAYLGYSVSSMFLRGGRRLFLSGAPRFSHRGKVIAFQLKKDGAVRVAQSLQGEQIGSYFGSELCPLDIDGDGTTDVLLVAAPMFLGPQNKETGRVYVYLVGQPSLLTLQRTLQPESPQDARFGFAMGALPDLNQDGFADVAVGAPLEDGHRGALYLYHGAQRGVRPRPAQRIAAVAMPQALSYFGRSVDGRLDLDGDDLVDVAVGAQGAAILLSSRPIVRLAPSLDVTPPAISVVQRDCKRRGQEATCLSAALCFQVTSRTPGHWDRRFHVRFTASLDEWTTAARAAFDGSGQRLSPRRLRLSVGNITCEQLHFHVLDTSDYLRPVSLSVTFALDNTTKPGPVLDEGSPTSIRKLVPFSKDCGPDNECVTDLVLQANMDIRGSRKDPFVVRGGRRKVLVSATLENKKENAYNTSLSLNFSRNLHLSSFTPQSNSPVKVECAAPTPHTRLCSVGHPVFQTGAKVTFLLEFEFSCSFLLSQVLVRLTATSSSLERNGTLRDNTAQTSAYIQYEPHLLFSSESTLHRYEVHPYGTLPVGPGPEFKTTLRVQNLGCYVVSGLIVSALLPAVAYGGNYFLSLSQVITNNASCTVQNLTEPPGPPVHPEELQHTSRLNESNTRCQVVRCHLGRLAKGTEISVGLLRLVHNEFFRRAKFKSLTVVSTFELSTEEGSVLLLTEASRWSESLLEVIQSRPVLISLWILIGSVLGGLLLLALLVFCLWKLGFFARKKIPEEEKREDKLEQ", "length": 1167, "header": "tr|E1BDD5-1|E1BDD5_BOVIN Isoform 1 of Integrin subunit alpha 10 OS=Bos taurus OX=9913 GN=ITGA10 PE=3 SV=1 CANONICAL=E1BDD5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRK3-1", "url": "https://www.uniprot.org/uniprotkb/E1BDD5/entry#A0AAA9SRK3-1", "sequence": { "sequence": "MEFPLIPHLFLPLMFLTGCPTYMDVVIVLDGSNSIYPWSEVQTFLRRLVGRLFIDPEQIQVGLVQYGESSVHEWSLGDFRTKEEVVRAARNLSRREGRETKTAQAIMMACTEGFSQSRGGRPEAARLLVVVTDGESHDGEELPTALQACEAGRVTRYGIAVLGHYLRRQRDPSSFLREIRAIASDPDEKFFFNVTDEAALTDIVDALGDRIFGLEGSHGENESSFGLEMSQIGFSTHQLKDGILFGMVGAYDWGGSVLWLEEGRRLFPPRTALEDEFPPALQNHAAYLGYSVSSMFLRGGRRLFLSGAPRFSHRGKVIAFQLKKDGAVRVAQSLQGEQIGSYFGSELCPLDIDGDGTTDVLLVAAPMFLGPQNKETGRVYVYLVGQPSLLTLQRTLQPESPQDARFGFAMGALPDLNQDGFADVAVGAPLEDGHRGALYLYHGAQRGVRPRPAQRIAAVAMPQALSYFGRSVDGRLDLDGDDLVDVAVGAQGAAILLSSRPIVRLAPSLDVTPPAISVVQRDCKRRGQEATCLSAALCFQVTSRTPGHWDRRFHVRFTASLDEWTTAARAAFDGSGQRLSPRRLRLSVGNITCEQLHFHVLDTSDYLRPVSLSVTFALDNTTKPGPVLDEGSPTSIRKLVPFSKDCGPDNECVTDLVLQANMDIRGSRKDPFVVRGGRRKVLVSATLENKKENAYNTSLSLNFSRNLHLSSFTPQSNSPVKVECAAPTPHTRLCSVGHPVFQTGAKVTFLLEFEFSCSFLLSQVLVRLTATSSSLERNGTLRDNTAQTSAYIQYEPHLLFSSESTLHRYEVHPYGTLPVGPGPEFKTTLRVQNLGCYVVSGLIVSALLPAVAYGGNYFLSLSQVITNNASCTVQNLTEPPGPPVHPEELQHTSRLNESNTRCQVVRCHLGRLAKGTEISVGLLRLVHNEFFRRAKFKSLTVVSTFELSTEEGSVLLLTEASRWSESLLEVIQSRPVLISLWILIGSVLGGLLLLALLVFCLWKLGFFARKKIPEEEKREDKLEQ", "length": 1024, "header": "tr|A0AAA9SRK3-1|E1BDD5_BOVIN Computationally mapped isoform of Integrin subunit alpha 10 OS=Bos taurus OX=9913 GN=ITGA10 PE=3 SV=1 CANONICAL=E1BDD5-1" }, "locus": { "chromosome": "3", "start_pos": 21476005, "end_pos": 21460548, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126818.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126818.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089004.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089004.1" } ] } }, { "isoform_ac": "E1BDD5-1", "url": "https://www.uniprot.org/uniprotkb/E1BDD5/entry#E1BDD5-1", "sequence": { "sequence": "MEFPLIPHLFLPLMFLTGLCSSFNLDVHRPRLFLGPPEAEFGYSVLQHVGGGRQWMLVGAPWDGPSGDRRGDVYRCLVGGSHSAPCAKGHLGDHPLGNSSRPAVNMHLGMSLLETDGNGGFMACAPLWSRACGSSVFSSGICARVDASFRPQGSLAPTAQRCPTYMDVVIVLDGSNSIYPWSEVQTFLRRLVGRLFIDPEQIQVGLVQYGESSVHEWSLGDFRTKEEVVRAARNLSRREGRETKTAQAIMMACTEGFSQSRGGRPEAARLLVVVTDGESHDGEELPTALQACEAGRVTRYGIAVLGHYLRRQRDPSSFLREIRAIASDPDEKFFFNVTDEAALTDIVDALGDRIFGLEGSHGENESSFGLEMSQIGFSTHQLKDGILFGMVGAYDWGGSVLWLEEGRRLFPPRTALEDEFPPALQNHAAYLGYSVSSMFLRGGRRLFLSGAPRFSHRGKVIAFQLKKDGAVRVAQSLQGEQIGSYFGSELCPLDIDGDGTTDVLLVAAPMFLGPQNKETGRVYVYLVGQPSLLTLQRTLQPESPQDARFGFAMGALPDLNQDGFADVAVGAPLEDGHRGALYLYHGAQRGVRPRPAQRIAAVAMPQALSYFGRSVDGRLDLDGDDLVDVAVGAQGAAILLSSRPIVRLAPSLDVTPPAISVVQRDCKRRGQEATCLSAALCFQVTSRTPGHWDRRFHVRFTASLDEWTTAARAAFDGSGQRLSPRRLRLSVGNITCEQLHFHVLDTSDYLRPVSLSVTFALDNTTKPGPVLDEGSPTSIRKLVPFSKDCGPDNECVTDLVLQANMDIRGSRKDPFVVRGGRRKVLVSATLENKKENAYNTSLSLNFSRNLHLSSFTPQSNSPVKVECAAPTPHTRLCSVGHPVFQTGAKVTFLLEFEFSCSFLLSQVLVRLTATSSSLERNGTLRDNTAQTSAYIQYEPHLLFSSESTLHRYEVHPYGTLPVGPGPEFKTTLRVQNLGCYVVSGLIVSALLPAVAYGGNYFLSLSQVITNNASCTVQNLTEPPGPPVHPEELQHTSRLNESNTRCQVVRCHLGRLAKGTEISVGLLRLVHNEFFRRAKFKSLTVVSTFELSTEEGSVLLLTEASRWSESLLEVIQSRPVLISLWILIGSVLGGLLLLALLVFCLWKLGFFARKKIPEEEKREDKLEQ", "length": 1167, "header": "tr|E1BDD5-1|E1BDD5_BOVIN Isoform 1 of Integrin subunit alpha 10 OS=Bos taurus OX=9913 GN=ITGA10 PE=3 SV=1 CANONICAL=E1BDD5-1" }, "locus": { "chromosome": "3", "start_pos": 21476005, "end_pos": 21460548, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011023.6", "url": "https://www.ensembl.org/id/ENSBTAT00000011023.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011023.3", "url": "https://www.ensembl.org/id/ENSBTAP00000011023.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506526", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506526", "resource": "KEGG Pathway" }, { "id": "R-BTA-216083", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216083", "resource": "Reactome", "description": "Integrin cell surface interactions" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LUL1-1", "protein_name": "Integrin alpha-10 isoform X2", "gene_name": "Itga10", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MARLSVPHLFLSLVLLAGLCSPFNLDEHHPRLFTGPPEAEFGYSVLQHVGGGQRWMLVGAPWDGPSGDRRGDVYRCSIGGSHSAPCAKGHLGDYQLGNSSQPAVNMHLGMSLLETHGDGGFMACAPLWSRACGSSVFSSGICAHVDASFQPRGSLAPTAQRCPTYMDVVIVLDGSNSIYPWSEVQTFLRRLVGRLFIDPEQIQVGLVQYGESPVHEWSLGDFRTKEEVVRAARNLSRREGRETRTAQAIMVACTEGFSQSRGGRPEAARLLVVVTDGESHDGEELPAALKACEAGRVTRYGIAVLGHYLRRQRDPSTFLREIRDIASDPDERFFFNVTDEAALTDIVDALGDRIFGLEGSRGENESSFGLEMSEIGFSIHRLQDGILFGMVGAYDWGGSVLWLEEGRRLFPPRTALEDEFPPALQNHAAYLGYSVSSMLLPGGRRLFLSGAPRFRHRGKVIAFQLKKDGALRVAQSLQGDQIGSYFGSELCPLDTDRDGITDVLLVAAPMFLGPQNKETGRVYVYVVGQQILLMLQGTLQPEHSQDSRFGFAMAALPDLNQDGFADVAVGAPLEDGHQGALYLYHGTQTGIRPHPTQRIAAVSMPQTLRYFGRSVDGRLDLDGDDLVDVAVGAHGAAILLSSQPIIHLLPTLDVVPPHISVVQKDCRRRGQEAACLTATLCFRVTSHTRGRWDRRFYIRFSASLDEWAAGARAAFDGSGQRLSPQQLQLSVGNVTCERLHFHVLETSDYLRPVALTVTFALDNTTKPGPVLDEGSPTSIRKLVPFSKDCGTDDECITDLVLQAHMDIRGSRKSPFVVHGGRQKLLVSATLENKKENAYNTSLSLRFSRNLHLASLTPQRAKSVRVECSVPSPHARECIVGHPVFQAGAKVTFLLEFEFSCTFLLGQVLVRLTASSSSLERNETLQDNTVQTSAFIRYEPHLMFSSESTLHRYEVHPYRTLPVGPGPEFKTTLRVQNLGCHMVSGLIISALLPAVAHGGNYFLSLSQVITSNASCTVQNLTEPPGPAVHPEELQHTSRLNGSNTQCQVVRCHLGQLAKGTEISVGLLRLVHNEFFRRAKFKSLTVVSTFKLETENGSVLQLTEASSGSESLLEVIQSRTTLISLWILIGSVLGGLLLLALLVFCLWKLGFFARKKIPKEEQTDEKLEQ", "length": 1167 }, "evidence": [ { "id": "E1BDD5", "url": "https://omabrowser.org/oma/group/E1BDD5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZW82-1", "protein_name": "Integrin subunit alpha 10", "gene_name": "Itga10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELPSIPHLFLPLALLTGLCSPFNLDEHHPRLFTGPPEAEFGYSVLQHVGGGQRWMLVGAPWDGPSGDRKGDVYRCSIGGFHSAPCTKGHLGDYQLGNSSQPAVNMHLGMSLLETDADGGFMACAPLWSRACGSSVFSSGICAHVDASFRLQGSLAPTAQRCPTYMDVVIVLDGSNSIYPWSEVQTFLRRLVGRLFIDPEQIQVGLVQYGENPVHEWSLGDFRTKEEVVRAARNLSRREGRETRTAQAIMVACTEGFSESRGGRPEAARLLVVVTDGESHDGEELPAALKACEAGRVTRYGIAVLGHYLRRQRDPSSFLREIRAIASDPDERFFFNVTDEAALTDIVDALGDRIFGLEGSRGENESSFGLEMSEIGFSIHRLQDGILFGMVGAYDWGGSVLWLEEGRRLFPPRTALEDEFPPALQNHAAYLGYSVSSMLLPGGRRLFLSGAPRFRHRGKVIAFQLKKDGVVKVTQSLQGDQIGSYFGSELCPLDTDMDGITNILLVAAPMFLGPQNKETGRIYVYVVGQQNLLMLQGTLQPDRSQDSRFGFAMAALPDLNHDGFSDVAVGAPLEDGHQGALYLYHGTQTGIRPHPTQRIAAGSMPQALRYFGRSVDGRLDLDGDDLVDVAVGAHGAAILFSSQPIIHLIPTLDVMPPHISVVQKDCKRRGQEAACLTASLCFQVKSQTPGRWDRRFHIRFSASLDEWTAGARAAFDGSGQRLSPGQLRLSVGNVTCEQLHFHALDTSDYLRPVALTVTFALDNTTKPGPVLAEGSSTSIRKLIPFSKDCGPDNECITDLVLQADMDIRGSRKSPFVVQGGRQKVLVSVTLENKKENAYNTSLSLSFSRNLHLASLTPQRAKSVKVECAVPSPHARLCIVGHPVFQAGAKVSFLLEFEFSCTFLLSQVSVRLTASSSSLERNETLQDNTAQTSAYIRYEPHLMFSSESTLHRYEVHPYRALPVGPGPEFKTTLRVQNLGCHVVSGLVVSALLPAVAHGGNYFLSLSQVISGNASCTVQNLTDPPGFPVHPEELQHTSRLNGSNTRCQAVRCHLGLLPKGTEISVGLLRLVHNEFFRRAKFKSVTVVSTFKLGTEKGSVLLLNEASQWRESHLEVIQTLPTLISLWILVGSVLGGLLLLALLVFCLWKLGFFTRKKIPKEEQSEGKLEQ", "length": 1167 }, "evidence": [ { "id": "E1BDD5", "url": "https://omabrowser.org/oma/group/E1BDD5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9Q6R1-1", "protein_name": "Integrin, alpha 10", "gene_name": "Itga10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESLSIPHLLLPLALLTGLCSSFNLDEHHPRLFTGPPEAEFGYSVLQHVGGGQRWMLVGAPWDGPSGDRRGDVYRCSIGGFHSAPCTKGHLGDYQLGNSSQPAVNMHLGMSLLETDADGGFMACAPLWSRACGSSVFSSGICARVDASFRPQGSLAPTAQRCPTYMDVVIVLDGSNSIYPWSEVQTFLRRLVGRLFIDPEQIQVGLVQYGENPVHEWSLGDFRTKEEVVRAARNLSRREGRETRTAQAIMVACTEGFSQSRGGRPEAARLLVVVTDGESHDGEELPAALKACEAGRVTRYGIAVLGHYLRRQRDPSSFLREIRAIASDPDERFFFNVTDEAALTDIVDALGDRIFGLEGSRGENESSFGLEMSEIGFSIHRLQDGILFGMVGAYDWGGSVLWLEEGRRLFPPQAALEDEFPPALQNHAAYLGYSVSSMLLPGGRRLFLSGAPRFRHRGKVIAFQLKKDGVVRVAQSLQGDQIGSYFGSELCPLDTDKDGITNILLVAAPMFLGPQNKETGRVYVYMVGQQNLLMLQGTLQPDRSQDSRFGFAMAALPDLNHDGFTDVAVGAPLEDGHRGALYLYHGTQTGIRPHPTQRIAAVSMPQALRYFGRSVDGRLDLDGDDLVDVAVGAHGAAVLFSSQPIIHLIPTLDVMPPHISVVQKDCKRRGQEAACLTAALCFQVVSQTPGRWDRRFYIRFSASLDEWTAGARAVFDGSGQRLSPRQLQLSVGNVTCEQLHFHALDTSDYLRPVALTVTFALDNTTKPGPVLAEGSSTTIRKLIPFSKDCGPDNECVTDLVLQADMDIRGSRKSPFVVQGGRQKVLVSATLENKKENAYNTSLSLSFSRNLHLASLTPQKAKSVKVECAVPSPHTRLCTVGHPVFQTGAKVSFLLEFEFSCTFLLSQVFVRLTASSSSLEMNETLQDNTAQTSAYIRYEPHLVFSSESTLHRYEVHPYRTLPMGPGPEFKTTLRVQNLGCHVVSGLVISALLPAVAHGGNYFLSLSQVISGNASCTVQNLTEPPGFPVHPEELQHASRLNGSNSRCQVVRCHLGLLAKGTEISVRLLRLVHNEFFRRAKFKSVTVVSTFKLGTEEGSVLLLNEASRSSESHLEVIQTHPTLISLWILVGSVLGGLLLLALLVFCLWKLGFFTRKKIPKEEESEEKLEQ", "length": 1167 }, "evidence": [ { "id": "E1BDD5", "url": "https://omabrowser.org/oma/group/E1BDD5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O75578-1", "protein_name": "Integrin alpha-10", "gene_name": "ITGA10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELPFVTHLFLPLVFLTGLCSPFNLDEHHPRLFPGPPEAEFGYSVLQHVGGGQRWMLVGAPWDGPSGDRRGDVYRCPVGGAHNAPCAKGHLGDYQLGNSSHPAVNMHLGMSLLETDGDGGFMACAPLWSRACGSSVFSSGICARVDASFQPQGSLAPTAQRCPTYMDVVIVLDGSNSIYPWSEVQTFLRRLVGKLFIDPEQIQVGLVQYGESPVHEWSLGDFRTKEEVVRAAKNLSRREGRETKTAQAIMVACTEGFSQSHGGRPEAARLLVVVTDGESHDGEELPAALKACEAGRVTRYGIAVLGHYLRRQRDPSSFLREIRTIASDPDERFFFNVTDEAALTDIVDALGDRIFGLEGSHAENESSFGLEMSQIGFSTHRLKDGILFGMVGAYDWGGSVLWLEGGHRLFPPRMALEDEFPPALQNHAAYLGYSVSSMLLRGGRRLFLSGAPRFRHRGKVIAFQLKKDGAVRVAQSLQGEQIGSYFGSELCPLDTDRDGTTDVLLVAAPMFLGPQNKETGRVYVYLVGQQSLLTLQGTLQPEPPQDARFGFAMGALPDLNQDGFADVAVGAPLEDGHQGALYLYHGTQSGVRPHPAQRIAAASMPHALSYFGRSVDGRLDLDGDDLVDVAVGAQGAAILLSSRPIVHLTPSLEVTPQAISVVQRDCRRRGQEAVCLTAALCFQVTSRTPGRWDHQFYMRFTASLDEWTAGARAAFDGSGQRLSPRRLRLSVGNVTCEQLHFHVLDTSDYLRPVALTVTFALDNTTKPGPVLNEGSPTSIQKLVPFSKDCGPDNECVTDLVLQVNMDIRGSRKAPFVVRGGRRKVLVSTTLENRKENAYNTSLSLIFSRNLHLASLTPQRESPIKVECAAPSAHARLCSVGHPVFQTGAKVTFLLEFEFSCSSLLSQVFVKLTASSDSLERNGTLQDNTAQTSAYIQYEPHLLFSSESTLHRYEVHPYGTLPVGPGPEFKTTLRVQNLGCYVVSGLIISALLPAVAHGGNYFLSLSQVITNNASCIVQNLTEPPGPPVHPEELQHTNRLNGSNTQCQVVRCHLGQLAKGTEVSVGLLRLVHNEFFRRAKFKSLTVVSTFELGTEEGSVLQLTEASRWSESLLEVVQTRPILISLWILIGSVLGGLLLLALLVFCLWKLGFFAHKKIPEEEKREEKLEQ", "length": 1167 }, "evidence": [ { "id": "E1BDD5", "url": "https://omabrowser.org/oma/group/E1BDD5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "E1BDD5", "url": "https://www.uniprot.org/uniprotkb/E1BDD5" } ], "pmid": "" }, { "name": "integrin-mediated signaling pathway", "id": "GO:0007229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007229", "evidence": [ { "database": "UniProtKB", "id": "E1BDD5", "url": "https://www.uniprot.org/uniprotkb/E1BDD5" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "E1BDD5", "url": "https://www.uniprot.org/uniprotkb/E1BDD5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BDD5", "url": "https://www.uniprot.org/uniprotkb/E1BDD5" } ], "pmid": "" }, { "name": "signaling receptor activity", "id": "GO:0038023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "database": "UniProtKB", "id": "E1BDD5", "url": "https://www.uniprot.org/uniprotkb/E1BDD5" } ], "pmid": "" }, { "name": "collagen binding involved in cell-matrix adhesion", "id": "GO:0098639", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098639", "evidence": [ { "database": "UniProtKB", "id": "E1BDD5", "url": "https://www.uniprot.org/uniprotkb/E1BDD5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "integrin complex", "id": "GO:0008305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008305", "evidence": [ { "database": "UniProtKB", "id": "E1BDD5", "url": "https://www.uniprot.org/uniprotkb/E1BDD5" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "E1BDD5", "url": "https://www.uniprot.org/uniprotkb/E1BDD5" } ], "pmid": "" }, { "name": "integrin alpha10-beta1 complex", "id": "GO:0034680", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034680", "evidence": [ { "database": "UniProtKB", "id": "E1BDD5", "url": "https://www.uniprot.org/uniprotkb/E1BDD5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1011, "end_pos": 1013, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1018, "end_pos": 1020, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1039, "end_pos": 1041, "annotation": "n_glycosylation_sequon" }, { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" }, { "start_pos": 336, "end_pos": 338, "annotation": "n_glycosylation_sequon" }, { "start_pos": 364, "end_pos": 366, "annotation": "n_glycosylation_sequon" }, { "start_pos": 733, "end_pos": 735, "annotation": "n_glycosylation_sequon" }, { "start_pos": 763, "end_pos": 765, "annotation": "n_glycosylation_sequon" }, { "start_pos": 839, "end_pos": 841, "annotation": "n_glycosylation_sequon" }, { "start_pos": 845, "end_pos": 847, "annotation": "n_glycosylation_sequon" }, { "start_pos": 921, "end_pos": 923, "annotation": "n_glycosylation_sequon" }, { "start_pos": 98, "end_pos": 100, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BDD5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1167, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BDD5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BDD5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BDD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDD5" }, { "id": "PS50234", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50234" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFA", "eco_id": "ECO_0000259", "start_pos": 167, "end_pos": 350, "start_aa": "Asp", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1011, "end_pos": 1013 }, { "start_pos": 1018, "end_pos": 1020 }, { "start_pos": 1039, "end_pos": 1041 }, { "start_pos": 234, 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"field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCP9-1", "uniprot_ac": "E1BCP9", "uniprot_id": "E1BCP9_BOVIN", "mass": { "chemical_mass": 73301.0, "monoisotopic_mass": 73301.0 }, "refseq": { "ac": "NP_001192931", "name": "beta-galactosidase-1-like protein precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192931" }, "gene_names": [ { "name": "GLB1L", "type": "recommended", "evidence": [ { "id": "E1BCP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCP9" } ] }, { "name": "GLB1L", "type": "synonym", "evidence": [ { "id": "NP_001192931", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192931" } ] } ], "protein_names": [ { "name": "beta-galactosidase", "type": "recommended", "evidence": [ { "id": "E1BCP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCP9/entry#names_and_taxonomy" } ] }, { "name": "3.2.1.23", "type": "synonym", "evidence": [ { "id": "E1BCP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCP9/entry#names_and_taxonomy" } ] }, { "name": "beta-galactosidase-1-like protein precursor", "type": "synonym", "evidence": [ { "id": "NP_001192931", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192931" } ] } ], "function": [ { "annotation": "Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.", "evidence": [ { "database": "UniProtKB", "id": "E1BCP9", "url": "https://www.uniprot.org/uniprotkb/E1BCP9#function" }, { "database": "UniProtKB", "id": "ARBA00002691", "url": "https://www.uniprot.org/uniprotkb/ARBA00002691#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCP9", "url": "https://www.uniprot.org/uniprotkb/E1BCP9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GLB1L", "url": "https://www.uniprot.org/uniprotkb/E1BCP9", "locus": { "chromosome": "2", "start_pos": 107186405, "end_pos": 107193108, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020611", "url": "https://www.ensembl.org/id/ENSBTAG00000020611" } ] } } ], "crossref": [ { "id": "E1BCP9", "url": "https://alphafold.ebi.ac.uk/entry/E1BCP9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020611", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020611", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532551", "url": "https://www.ncbi.nlm.nih.gov/gene/532551", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001944", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001944", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048912", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048912", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048913", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048913", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532551", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532551", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HERQYLH", "url": "https://omabrowser.org/oma/group/HERQYLH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCP9", "url": "https://www.orthodb.org/?gene=E1BCP9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23421", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23421", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01301", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01301", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21317", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21317", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21467", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21467", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2022857", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022857", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2024101", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2024101", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9840310", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9840310", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192931", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SUR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCP9", "url": "https://www.uniprot.org/uniprotkb/E1BCP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCP9-1", "url": "https://www.uniprot.org/uniprotkb/E1BCP9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPKKPLCLPFLLLPLLTLLLPQADARSFVVDRDHNRFLLDGAPFRYVSGSLHYFRVPRVLWADRLLKMRMSGLNVVQFYVPWNYHEPEPGVYNFNGSRDLFAFLKEATLANLLVILRPGPYICAEWEMGGLPAWLLRKPKIHLRTSDPDFLAAVDSWFKVLLPRIYPWLYHNGGNIISIQVENEYGSYRACDVSYMRHLAGLFRALLGDRILLFTTDGPEGLKCGSLQGLYTTVDFGPADNMTKIFGLLRKYEPRGPLVNSEYYTGWLDYWGQNHSTRSIPAVTKGLEKMLKLGASVNMYMFHGGTNFGYWNGADEKGRFLPITTSYDYDAPISEAGDPTPKLFAIRNVISKFQEVPLGPLPPPSPKMTLGPLNLHLDGNLLDFLDFLCPQGPIHSVLPMTFEAVNQVHGYMLYRTYLPHTVSEPTQLWVPNNGVHDRAYVMVDGVFQGVLERNMKHNLFLMGKIGATLDVLLENMGRLSFGSNSSDFKGLLQPPILGQTILTQWLMFPLKVDNLVKGWFPIQPLKHSHPQTPSGPTFYSTTFPILNSGGDTFLFLPGWTKGQVWINGFNLGRYWTKRGPQQTLYVPRPLLFPRGAHNRITLLELENVPPQPQIQFLDRPILNSTKHRTYVYSLSSASEPMELSGH", "length": 647, "header": "tr|E1BCP9-1|E1BCP9_BOVIN Isoform 1 of beta-galactosidase OS=Bos taurus OX=9913 GN=GLB1L PE=3 SV=1 CANONICAL=E1BCP9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUR3-1", "url": "https://www.uniprot.org/uniprotkb/E1BCP9/entry#A0AAA9SUR3-1", "sequence": { "sequence": "MAPKKPLCLPFLLLPLLTLLLPQADARSFVVDRDHNRFLLDGAPFRYVSGSLHYFRVPRVLWADRLLKMRMSGLNVVQFYVPWNYHEPEPGVYNFNGSRDLFAFLKEATLANLLVILRPGPYICAEWEMGGLPAWLLRKPKIHLRTSDPADNMTKIFGLLRKYEPRGPLVNSEYYTGWLDYWGQNHSTRSIPAVTKGLEKMLKLGASVNMYMFHGGTNFGYWNGADEKGRFLPITTSYDYDAPISEAGDPTPKLFAIRNVISKFQEVPLGPLPPPSPKMTLGPLNLHLDGNLLDFLDFLCPQGPIHSVLPMTFEAVNQVHGYMLYRTYLPHTVSEPTQLWVPNNGVHDRAYVMVDGVFQGVLERNMKHNLFLMGKIGATLDVLLENMGRLSFGSNSSDFKGLLQPPILGQTILTQWLMFPLKVDNLVKGWFPIQPLKHSHPQTPSGPTFYSTTFPILNSGGDTFLFLPGWTKGQVWINGFNLGRYWTKRGPQQTLYVPRPLLFPRGAHNRITLLELENVPPQPQIQFLDRPILNSTKHRTYVYSLSSASEPMELSGH", "length": 557, "header": "tr|A0AAA9SUR3-1|E1BCP9_BOVIN Computationally mapped isoform of beta-galactosidase OS=Bos taurus OX=9913 GN=GLB1L PE=3 SV=1 CANONICAL=E1BCP9-1" }, "locus": { "chromosome": "2", "start_pos": 107193050, "end_pos": 107186577, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096572.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096572.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086903.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086903.1" } ] } }, { "isoform_ac": "E1BCP9-1", "url": "https://www.uniprot.org/uniprotkb/E1BCP9/entry#E1BCP9-1", "sequence": { "sequence": "MAPKKPLCLPFLLLPLLTLLLPQADARSFVVDRDHNRFLLDGAPFRYVSGSLHYFRVPRVLWADRLLKMRMSGLNVVQFYVPWNYHEPEPGVYNFNGSRDLFAFLKEATLANLLVILRPGPYICAEWEMGGLPAWLLRKPKIHLRTSDPDFLAAVDSWFKVLLPRIYPWLYHNGGNIISIQVENEYGSYRACDVSYMRHLAGLFRALLGDRILLFTTDGPEGLKCGSLQGLYTTVDFGPADNMTKIFGLLRKYEPRGPLVNSEYYTGWLDYWGQNHSTRSIPAVTKGLEKMLKLGASVNMYMFHGGTNFGYWNGADEKGRFLPITTSYDYDAPISEAGDPTPKLFAIRNVISKFQEVPLGPLPPPSPKMTLGPLNLHLDGNLLDFLDFLCPQGPIHSVLPMTFEAVNQVHGYMLYRTYLPHTVSEPTQLWVPNNGVHDRAYVMVDGVFQGVLERNMKHNLFLMGKIGATLDVLLENMGRLSFGSNSSDFKGLLQPPILGQTILTQWLMFPLKVDNLVKGWFPIQPLKHSHPQTPSGPTFYSTTFPILNSGGDTFLFLPGWTKGQVWINGFNLGRYWTKRGPQQTLYVPRPLLFPRGAHNRITLLELENVPPQPQIQFLDRPILNSTKHRTYVYSLSSASEPMELSGH", "length": 647, "header": "tr|E1BCP9-1|E1BCP9_BOVIN Isoform 1 of beta-galactosidase OS=Bos taurus OX=9913 GN=GLB1L PE=3 SV=1 CANONICAL=E1BCP9-1" }, "locus": { "chromosome": "2", "start_pos": 107193050, "end_pos": 107186577, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027467.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027467.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027467.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027467.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:532551", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532551", "resource": "KEGG Pathway" }, { "id": "R-BTA-2022857", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022857", "resource": "Reactome", "description": "Keratan sulfate degradation" }, { "id": "R-BTA-2024101", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2024101", "resource": "Reactome", "description": "CS/DS degradation" }, { "id": "R-BTA-9840310", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9840310", "resource": "Reactome", "description": "Glycosphingolipid catabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZI47-1", "protein_name": "beta-galactosidase", "gene_name": "GLB1L", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGLPALGLLLAAALLRTEAAPPARSFQIDFERDCFRKDGAPFRYVSGSVHYARVPRPAWRDRLLRLYMAGLNAVQVYVPWNYHEPQPGVYDFSGDRDVEAFLDLAAELGLLVILRPGPYICAEWEMGGLPAWLLWKADIILRSSDPAYLAAVDAWLHVLLPKIKPRLYQHGGNIISVQVENEYGSYYACDLGYLQHLLGTFRALLGPEVLLFTTDGAQVEELHCGTLRGLYATIDFGPDSNVTEAFDAQRHVEPMGPLVNSEYYTGWLDYWGGPHASTSATLVAQGLADMLQLGANVNMYMFHGGTNFAYWSGADFKDQYKPVTTSYDYDAPLSEAGDPTEKLFAIRTVISKFQPLPVGPMPPPTPKYAYGRVALHKYADLLDVLDVLSPSGPIQRQFPLIFEAVKQAHGFMLYRTQLPYDILAPATLSAPPHSICDRGYVMLQKEYQGTLERDGQTELRVKGKAGDTLDVLLENMGRISFGANFSDFKGLLGNLSLDSRPLSKWLIYPLAIDAAIQQGWPHAALPKSSCRGRAGPAFYTGTFETPGIAWDTFVKFPGWSKGQLWINGFNLGRYWPRQGPQQTLFVPGSILRVGCPNNITVLELEEAPPNPFLLFLDQPLFNTTLSHSSPDKE", "length": 633 }, "evidence": [ { "id": "E1BCP9", "url": "https://omabrowser.org/oma/group/E1BCP9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B1WBS6-1", "protein_name": "beta-galactosidase", "gene_name": "Glb1l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPPDLPSLLLRLVILLLLSQAEARSFVVDRQHDRFLLDGVPFRYISGSLHYFRVPRVLWADRLLKMKLSGLNAVQFYVPWNYHEPEPGIYNFNGSRDLTAFLNEAAKANLLVILRPGPYICAEWEMGGLPSWLLRNRDIHLRTSDPAFLHAVDSWFKVLLPKIYPFLYHNGGNIISIQVENEYGSYKVCDFKYMRHLAGLFRALLGDEILLFTTDGPQGLRCGSLQGLYATVDFGPADNVTRIFSLLREYEPHGPLVNSEYYTGWLDYWGQNHSTRSTPAVARGLERILKLGASVNMYMFHGGTNFGYWNGADDKGYFLPITTSYDYDAPISEAGDPTPKLFAIQNVISKFQEIPLGPLPPPSPKMKLGPLTMSLDGNLLSFLDFLCPEGPIHSVLPLTFEAVKLDRGFMLYRTYMTYTVSEPTPLWVPNNGIHDRAYVMVDGVLKGILERSLKEELYLTGKVGTRLDILLENMGRLSFGSNHSDFKGLLEPPLLGQTVLTGWMMFPLKVDKLVKWWIPLQLMKRAQPQAPSVPAFYSAKFPALGLLGDTFLYLPGWTKGQVWINGFNLGRYWTMRGPQQTLYVPRPLLFGSSINKITLLELEDVPHDPQIQFLDKPILNSTLHWGYNYLLSEPQGSYEPIELSGH", "length": 646 }, "evidence": [ { "id": "E1BCP9", "url": "https://omabrowser.org/oma/group/E1BCP9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6UWU2-1", "protein_name": "Beta-galactosidase-1-like protein", "gene_name": "GLB1L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPKKLSCLRSLLLPLSLTLLLPQADTRSFVVDRGHDRFLLDGAPFRYVSGSLHYFRVPRVLWADRLLKMRWSGLNAIQFYVPWNYHEPQPGVYNFNGSRDLIAFLNEAALANLLVILRPGPYICAEWEMGGLPSWLLRKPEIHLRTSDPDFLAAVDSWFKVLLPKIYPWLYHNGGNIISIQVENEYGSYRACDFSYMRHLAGLFRALLGEKILLFTTDGPEGLKCGSLRGLYTTVDFGPADNMTKIFTLLRKYEPHGPLVNSEYYTGWLDYWGQNHSTRSVSAVTKGLENMLKLGASVNMYMFHGGTNFGYWNGADKKGRFLPITTSYDYDAPISEAGDPTPKLFALRDVISKFQEVPLGPLPPPSPKMMLGPVTLHLVGHLLAFLDLLCPRGPIHSILPMTFEAVKQDHGFMLYRTYMTHTIFEPTPFWVPNNGVHDRAYVMVDGVFQGVVERNMRDKLFLTGKLGSKLDILVENMGRLSFGSNSSDFKGLLKPPILGQTILTQWMMFPLKIDNLVKWWFPLQLPKWPYPQAPSGPTFYSKTFPILGSVGDTFLYLPGWTKGQVWINGFNLGRYWTKQGPQQTLYVPRFLLFPRGALNKITLLELEDVPLQPQVQFLDKPILNSTSTLHRTHINSLSADTLSASEPMELSGH", "length": 654 }, "evidence": [ { "id": "E1BCP9", "url": "https://omabrowser.org/oma/group/E1BCP9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VC60-1", "protein_name": "Beta-galactosidase-1-like protein", "gene_name": "Glb1l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPPDLPSLLLRLVVLLLLSQAEARSFVVDREHDRFLLDGVPFRYVSGSLHYFRVPPVLWADRLLKMQLSGLNAVQFYVPWNYHEPEPGIYNFNGSRDLIAFLNEAAKVNLLVILRPGPYICAEWEMGGLPSWLLRNPNIHLRTSDPAFLEAVDSWFKVLLPKIYPFLYHNGGNIISIQVENEYGSYKACDFKYMRHLAGLFRALLGDKILLFTTDGPHGLRCGSLQGLYTTIDFGPADNVTRIFSLLREYEPHGPLVNSEYYTGWLDYWGQNHSTRSSPAVAQGLEKMLKLGASVNMYMFHGGTNFGYWNGADEKGRFLPITTSYDYDAPISEAGDPTPKLFAIRNVISKFQEIPLGPLPPPSPKMKFGPLTMSLDGNLLSFLDFLCPQGPIHSVLPLTFEAVKLDHGFMLYRTYLTSPVLEPTPFWVPNNGIHDRAYVMVDGVLKGVLERSLKQELYLTGTVGTRLDILLENMGRLSFGSNHSDFKGLLEAPLLGQTILTEWMMFPLKVDKLVKWWFPLQLMKRALPQASSVPAFYSAKFPVFGLLGDTFLYLPGWTKGQVWINGFNLGRYWTMRGPQQTLYVPRLLLFGRSINKITLLELENVPHNPQVQFLDKPILNSTLHWGYNFLLSETQGSFEPMELSGH", "length": 646 }, "evidence": [ { "id": "E1BCP9", "url": "https://omabrowser.org/oma/group/E1BCP9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "E1BCP9", "url": "https://www.uniprot.org/uniprotkb/E1BCP9" } ], "pmid": "" }, { "name": "galactose catabolic process", "id": "GO:0019388", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019388", "evidence": [ { "database": "UniProtKB", "id": "E1BCP9", "url": "https://www.uniprot.org/uniprotkb/E1BCP9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "beta-galactosidase activity", "id": "GO:0004565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004565", "evidence": [ { "database": "UniProtKB", "id": "E1BCP9", "url": "https://www.uniprot.org/uniprotkb/E1BCP9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "vacuole", "id": "GO:0005773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005773", "evidence": [ { "database": "UniProtKB", "id": "E1BCP9", "url": "https://www.uniprot.org/uniprotkb/E1BCP9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 242, "end_pos": 244, "annotation": "n_glycosylation_sequon" }, { "start_pos": 275, "end_pos": 277, "annotation": "n_glycosylation_sequon" }, { "start_pos": 485, "end_pos": 487, "annotation": "n_glycosylation_sequon" }, { "start_pos": 624, "end_pos": 626, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-1605624", "name": "Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal membrane, lysosomal lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MDX6-1", "A0ABI0P643-1", "A0A3Q1NDQ7-1", "E1BCP9-1" ], "evidence": [ { "id": "R-BTA-1605624", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1605624" } ] }, { "id": "R-BTA-1606312", "name": "GLB1 hydrolyzes SapB/C:LacCer", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MDX6-1", "A0ABI0P643-1", "A0A3Q1NDQ7-1", "E1BCP9-1" ], "evidence": [ { "id": "R-BTA-1606312", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1606312" } ] }, { "id": "R-BTA-1630306", "name": "GLB1 hydrolyses a glycosaminoglycan", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [ "R-ALL-2104997" ], "output_participant_list": [], "enzyme_list": [ "F1MDX6-1", "A0ABI0P643-1", "A0A3Q1NDQ7-1", "E1BCP9-1" ], "evidence": [ { "id": "R-BTA-1630306", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1630306" } ] }, { "id": "R-BTA-2090079", "name": "GLB1 hydrolyses linker chain(2)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [ "R-ALL-2090075" ], "output_participant_list": [ "R-ALL-2090063" ], "enzyme_list": [ "F1MDX6-1", "A0ABI0P643-1", "A0A3Q1NDQ7-1", "E1BCP9-1" ], "evidence": [ { "id": "R-BTA-2090079", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2090079" } ] }, { "id": "R-BTA-9840795", "name": "Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. 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"id": "PF00014", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00014", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00092", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00092", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1442490", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1442490", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1650814", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1650814", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-186797", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-186797", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2022090", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022090", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216083", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3000178", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8948216", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948216", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SV57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV57", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV57-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T393", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T393", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T393-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T393-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAB4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB91", "url": "https://www.uniprot.org/uniprotkb/E1BB91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB91-1", "url": "https://www.uniprot.org/uniprotkb/E1BB91-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRKHRHLPLVAILCLFFSGFSFTRGQQQPDVKNGAAADIIFLVDSSWSIGKEHFQLVREFLYDVIESLAVGDNDFRFALVQFNGNPHTEFLFNTYRSKQEVLSHVSNMSYIGGSNQTGKGLAYVMQNHLTEAAGSRASDGVPQVIVVLTHGHSEDGLALPSAELKSADVNVFAIGVEDADEAALKEIASEPLNMHVFNLENYTSLHDIVGNLVACVRSSMAPERAGGTEIPKDITAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLERLSIGTQQIRVGVVQYSDEPRTMFSLNSYSTKAQVLDAVKALGFIGGELANVGLALDFVVENHFTRAGGSRAEEGVPQVLVLISAGPSSDEIRDGVVALKQASVFSFGLGAQAASKAELQHIATNDNLVFTVPEFRSLGDVQEQLLPYIVGVAQRHIVLQPPTIVTQVIEVNKRDIVFLVDGSSKLGLTNFNAIRDFIAKVIQRLEIRQDLIQVAVAQYADTVRPEFYFNTYPSKREVINAVRKMKALDGSALYTGSALDFVRNNLFTEAAGYRAAEGVPKLLVLVTGGKSLDAVSQPAQELKRSGILAFAVGNKVADQAELEEIAFDSSLVFTATEFRPAPLQGVLPGLLGPLRTLTGTTEVRVNKRDIIFLLDGSSNVGETNFPYVRDFVMNLVNSLDVGSDHIRVGLVQFSDTPVTEFSLNTYPTKSELLAHLRQMQLQGGSVLNTGAALSYVHANHFTEAGGSRIQDHVPQLLLLLTAGQSEDSYLQAANALARAGILTFCVGTSQADRAELEEIAFNPGLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLMGQFTAARDFLYKVIDELDVKPEGTRVAVAQFSDDVKVESRFDQHQNKPEILNLVKRMKLKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGKSSDRVDTPALNLKQSGVVPFILQAKNADPAELELIVPSPAFILVAESLPKIGDLQPQIVNLLKSVQNGAPAPVSVEKDVVFLIDGSEGVRSGFPLLKEFVQRVVESLDVGPDRVRVAVVQYSDRTRPEFYLNSYMDQQSVVGAIRGLTLLGGPAPNTGAALEFVLRNILVGSAGSRIAEGVPQLLIVLTADRSGDDVRGPSVVLRRGGAVPIGIGIGNADITEMQTLSFVPDFAVVIPTFRQLGTIQQVISERVTQLSREELSRLQASVTPLTTPVVSSKRDVVFLIDGSQSAGPEFQYIRTLIERLVDYLDVGFDTTRVAVIQFSDDPRVEFLLNVHSSKDEVQNAVRRLRPKGGRQVNVGGALEYVARNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVEDSAIELKQFGVAPLTIARNVDQEELVKISLSPEYVFSVNTFRELPSLEQKLLTPLTTLTAGQIQQLLASTRYPPPAVESDAADIVFLIDSSDGVKPDGIAHIRDFVIRIVRRLNVGPNKVRIGVLQFSNDVFPEFQLKTYKSQASVLDAIRRLRFKGGSPLNTGKALEFVARNYFVKSAGSRIEDGVPQHLVLFLGGKSQDDISRYSQVIKSAGIASLGVGDRNIDRTELQTITSDPRLVFTVREFRDLPSIEERMVNSFGSSGVTPAPPGVDTPSPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEGGDSIQVGLVQYNSDPTDEFFLKDFPTKQQIIDAINKVVYKGGRHANTKVGLEHLRRNHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQEASMALTQRGVKVFAVGVRNIDSEEVGKIASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDVSKACNLDVILGFDGSGDQNVFVAQKGLEPKVDTILRRISQMQKISCSGSQLPTVRVSVVALTPSGPVEAFDFAEYQPELFEKFQNMRAQHPYVLTADTLKLYQNKFRQASMDNVKVVIHFTDGVDGDLADLQRASEELRQEGVRALILVGLERVANLEQLMQLEFGRGFTYNRPLRLNLLDLDYELAEQLDNIAEKACCGIPCKCSGQRGDRGPIGSIGPKGIPGEDGYRGYPGDEGGPGERGPPGVNGTQGFQGCPGQRGVKGSRGFPGEKGELGEIGLDGLDGEDGDKGLPGTSGEKGSPGRRGDKGPKGDKGERGDVGIRGDPGNSGQDSQQRGAKGETGDIGPVVQCSPFLPVQSNLPLCGSCGGRGGSPPRSTYVGILLLQGPPGPTGPPGLIGEQGIPGPRVSLAWTLSKSGEPGDPGPKGSIGNRGPRGETGDDGRDGVGSEGRIGKKVFICRGGNPGEPGTDGPPGPKGIRGRRGNSGPPGIAGQKGDPGYPGPSGYKGSRGDSMDQCALVQSIKDKCRPLECPVFPTELAFALDTSEGVTQDRFSQMREVVLKILDDLTIAESNCPRGARVAVVTYNNEVTTEIRFADSKKKSVLLDKIKNLQVSLTSKQQSLETAMSFVARNTFKRVRSGFLMRKVAVFFSNKPTRATPQLREAVLKLSDAGITPLFLTSQEDRQLINALQINNTAVGHALVLPAGGDLTDFLKNVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDSSESTTPFQFNEMRKYIEYLVRQLDVSPDPKASQHFARVAVVQHAPYEAVDNASVPPVKVEFSLTDYGSKEKLLAFLGSRMTQLQGTRALGRAIDYTIENIFESAPNPRDLKIVVLMLTGEVQKQQLEEAQRAILQAKCKGYFFVILGIGRKVNVKELYSSASEPNDVFFKLVDKSTELNEEPLMRFGRLLPSFVSSKDAFYLSPDIRKQCDWFQADQPAKNLVQFGYKQINVPNNVTSSPTSKLVTTTKPVITTTKPITVVNLPASKPAATRPVDERPAAGRSVATKMDSARPVATKTEATKPAAAAKPAAAKPAPARPPTAARSMATRSEAPRPQAVKLAASRPGAAKPVVKAPREIHVSEVTENSAKLHWERPEPPSPYLYNLTVTSAHDQAVVLKQNLTVTDRVIGGLLPGQTYHVTVTCSLRSQVRAIYQGSFSTKKIQPPPPQTERSASSATINLVVSADRLAGSKADICKLPKDGGTCREFVLKWYYDSVTENCARFWYGGCGGNENRFNSQDECEKVCPPVPIKQPGVIAAMGT", "length": 3132, "header": "tr|E1BB91-1|E1BB91_BOVIN Isoform 1 of Collagen alpha-3(VI) chain OS=Bos taurus OX=9913 GN=COL6A3 PE=1 SV=3 CANONICAL=E1BB91-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SV57-1", "url": "https://www.uniprot.org/uniprotkb/E1BB91/entry#A0AAA9SV57-1", "sequence": { "sequence": "MRKHRHLPLVAILCLFFSGFSFTRGQQQPDVKNGAAADIIFLVDSSWSIGKEHFQLVREFLYDVIESLAVGDNDFRFALVQFNGNPHTEFLFNTYRSKQEVLSHVSNMSYIGGSNQTGKGLAYVMQNHLTEAAGSRASDGVPQVIVVLTHGHSEDGLALPSAELKSADVNVFAIGVEDADEAALKEIASEPLNMHVFNLENYTSLHDIVGNLVACVRSSMAPERAGGTEIPKDITAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLERLSIGTQQIRVGVVQYSDEPRTMFSLNSYSTKAQVLDAVKALGFIGGELANVGLALDFVVENHFTRAGGSRAEEGVPQVLVLISAGPSSDEIRDGVVALKQASVFSFGLGAQAASKAELQHIATNDNLVFTVPEFRSLGDVQEQLLPYIVGVAQRHIVLQPPTIVTQVIEVNKRDIVFLVDGSSKLGLTNFNAIRDFIAKVIQRLEIRQDLIQVAVAQYADTVRPEFYFNTYPSKREVINAVRKMKALDGSALYTGSALDFVRNNLFTEAAGYRAAEGVPKLLVLVTGGKSLDAVSQPAQELKRSGILAFAVGNKVADQAELEEIAFDSSLVFTATEFRPAPLQGVLPGLLGPLRTLTGTTEESKRDILFLFDGSANLMGQFTAARDFLYKVIDELDVKPEGTRVAVAQFSDDVKVESRFDQHQNKPEILNLVKRMKLKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGKSSDRVDTPALNLKQSGVVPFILQAKNADPAELELIVPSPAFILVAESLPKIGDLQPQIVNLLKSVQNGAPAPVSVEKDVVFLIDGSEGVRSGFPLLKEFVQRVVESLDVGPDRVRVAVVQYSDRTRPEFYLNSYMDQQSVVGAIRGLTLLGGPAPNTGAALEFVLRNILVGSAGSRIAEGVPQLLIVLTADRSGDDVRGPSVVLRRGGAVPIGIGIGNADITEMQTLSFVPDFAVVIPTFRQLGTIQQVISERVTQLSREELSRLQASVTPLTTPVVSSKRDVVFLIDGSQSAGPEFQYIRTLIERLVDYLDVGFDTTRVAVIQFSDDPRVEFLLNVHSSKDEVQNAVRRLRPKGGRQVNVGGALEYVARNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVEDSAIELKQFGVAPLTIARNVDQEELVKISLSPEYVFSVNTFRELPSLEQKLLTPLTTLTAGQIQQLLASTRYPPPAVESDAADIVFLIDSSDGVKPDGIAHIRDFVIRIVRRLNVGPNKVRIGVLQFSNDVFPEFQLKTYKSQASVLDAIRRLRFKGGSPLNTGKALEFVARNYFVKSAGSRIEDGVPQHLVLFLGGKSQDDISRYSQVIKSAGIASLGVGDRNIDRTELQTITSDPRLVFTVREFRDLPSIEERMVNSFGSSGVTPAPPGVDTPSPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEGGDSIQVGLVQYNSDPTDEFFLKDFPTKQQIIDAINKVVYKGGRHANTKVGLEHLRRNHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQEASMALTQRGVKVFAVGVRNIDSEEVGKIASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDVSKACNLDVILGFDGSGDQNVFVAQKGLEPKVDTILRRISQMQKISCSGSQLPTVRVSVVALTPSGPVEAFDFAEYQPELFEKFQNMRAQHPYVLTADTLKLYQNKFRQASMDNVKVVIHFTDGVDGDLADLQRASEELRQEGVRALILVGLERVANLEQLMQLEFGRGFTYNRPLRLNLLDLDYELAEQLDNIAEKACCGIPCKCSGQRGDRGPIGSIGPKGIPGEDGYRGYPGDEGGPGERGPPGVNGTQGFQGCPGQRGVKGSRGFPGEKGELGEIGLDGLDGEDGDKGLPGTSGEKGSPGRRGDKGPKGDKGERGDVGIRGDPGNSGQDSQQRGAKGETGDIGPVGLPGRDGVSGGPGEPGKSGGFGRRGPAGAKGNQGGPGQQGPVGEQGTRGAQGPPGPTGPPGLIGEQGIPGPRGGGGTAGAPGERGRTGPLGRKGEPGDPGPKGSIGNRGPRGETGDDGRDGVGSEGRIGKKGERGFPGYPGPKGNPGEPGTDGPPGPKGIRGRRGNSGPPGIAGQKGDPGYPGPSGYKGSRGDSMDQCALVQSIKDKCPCCYGPLECPVFPTELAFALDTSEGVTQDRFSQMREVVLKILDDLTIAESNCPRGARVAVVTYNNEVTTEIRFADSKKKSVLLDKIKNLQVSLTSKQQSLETAMSFVARNTFKRVRSGFLMRKVAVFFSNKPTRATPQLREAVLKLSDAGITPLFLTSQEDRQLINALQINNTAVGHALVLPAGGDLTDFLKNVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDSSESTTPFQFNEMRKYIEYLVRQLDVSPDPKASQHFARVAVVQHAPYEAVDNASVPPVKVEFSLTDYGSKEKLLAFLGSRMTQLQGTRALGRAIDYTIENIFESAPNPRDLKIVVLMLTGEVQKQQLEEAQRAILQAKCKGYFFVILGIGRKVNVKELYSSASEPNDVFFKLVDKSTELNEEPLMRFGRLLPSFVSSKDAFYLSPDIRKQCDWFQADQPAKNLVQFGYKQINVPNNVTSSPTSKLVTTTKPVITTTKPITVVNLPASKPAATRPVDERPAAGRSVATKMDSARPVATKTEATKPVATKTEATKTEAAKPVVTKAEAAKPTATKTEATKTEAAKLMATKTEATKPVAARPEAAKTATARPAAAAKPAAAKPAPARPPTAARSMATRSEAPRPQAVKLAASRPGAAKPVVKAPREIHVSEVTENSAKLHWERPEPPSPYLYNLTVTSAHDQAVVLKQNLTVTDRVIGGLLPGQTYHVTVTCSLRSQVRAIYQGSFSTKKIQPPPPQTERSASSATINLVVSADRLAGSKADICKLPKDGGTCREFVLKWYYDSVTENCARFWYGGCGGNENRFNSQDECEKVCPPVPIKQPGVIAAMGT", "length": 3031, "header": "tr|A0AAA9SV57-1|E1BB91_BOVIN Computationally mapped isoform of Collagen alpha-3(VI) chain OS=Bos taurus OX=9913 GN=COL6A3 PE=1 SV=1 CANONICAL=E1BB91-1" }, "locus": { "chromosome": "3", "start_pos": 116855219, "end_pos": 116782468, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132038.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132038.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090354.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090354.1" } ] } }, { "isoform_ac": "A0AAA9T393-1", "url": "https://www.uniprot.org/uniprotkb/E1BB91/entry#A0AAA9T393-1", "sequence": { "sequence": "MRKHRHLPLVAILCLFFSGFSFTRGQQQPAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLERLSIGTQQIRVGVVQYSDEPRTMFSLNSYSTKAQVLDAVKALGFIGGELANVGLALDFVVENHFTRAGGSRAEEGVPQVLVLISAGPSSDEIRDGVVALKQASVFSFGLGAQAASKAELQHIATNDNLVFTVPEFRSLGDVQEQLLPYIVGVAQRHIVLQPPTIVTQVIEVNKRDIVFLVDGSSKLGLTNFNAIRDFIAKVIQRLEIRQDLIQVAVAQYADTVRPEFYFNTYPSKREVINAVRKMKALDGSALYTGSALDFVRNNLFTEAAGYRAAEGVPKLLVLVTGGKSLDAVSQPAQELKRSGILAFAVGNKVADQAELEEIAFDSSLVFTATEFRPAPLQGVLPGLLGPLRTLTGTTEVRVNKRDIIFLLDGSSNVGETNFPYVRDFVMNLVNSLDVGSDHIRVGLVQFSDTPVTEFSLNTYPTKSELLAHLRQMQLQGGSVLNTGAALSYVHANHFTEAGGSRIQDHVPQLLLLLTAGQSEDSYLQAANALARAGILTFCVGTSQADRAELEEIAFNPGLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLMGQFTAARDFLYKVIDELDVKPEGTRVAVAQFSDDVKVESRFDQHQNKPEILNLVKRMKLKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGKSSDRVDTPALNLKQSGVVPFILQAKNADPAELELIVPSPAFILVAESLPKIGDLQPQIVNLLKSVQNGAPAPVSVEKDVVFLIDGSEGVRSGFPLLKEFVQRVVESLDVGPDRVRVAVVQYSDRTRPEFYLNSYMDQQSVVGAIRGLTLLGGPAPNTGAALEFVLRNILVGSAGSRIAEGVPQLLIVLTADRSGDDVRGPSVVLRRGGAVPIGIGIGNADITEMQTLSFVPDFAVVIPTFRQLGTIQQVISERVTQLSREELSRLQASVTPLTTPVVSSKRDVVFLIDGSQSAGPEFQYIRTLIERLVDYLDVGFDTTRVAVIQFSDDPRVEFLLNVHSSKDEVQNAVRRLRPKGGRQVNVGGALEYVARNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVEDSAIELKQFGVAPLTIARNVDQEELVKISLSPEYVFSVNTFRELPSLEQKLLTPLTTLTAGQIQQLLASTRYPPPAVESDAADIVFLIDSSDGVKPDGIAHIRDFVIRIVRRLNVGPNKVRIGVLQFSNDVFPEFQLKTYKSQASVLDAIRRLRFKGGSPLNTGKALEFVARNYFVKSAGSRIEDGVPQHLVLFLGGKSQDDISRYSQVIKSAGIASLGVGDRNIDRTELQTITSDPRLVFTVREFRDLPSIEERMVNSFGSSGVTPAPPGVDTPSPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEGGDSIQVGLVQYNSDPTDEFFLKDFPTKQQIIDAINKVVYKGGRHANTKVGLEHLRRNHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQEASMALTQRGVKVFAVGVRNIDSEEVGKIASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDVSKACNLDVILGFDGSGDQNVFVAQKGLEPKVDTILRRISQMQKISCSGSQLPTVRVSVVALTPSGPVEAFDFAEYQPELFEKFQNMRAQHPYVLTADTLKLYQNKFRQASMDNVKVVIHFTDGVDGDLADLQRASEELRQEGVRALILVGLERVANLEQLMQLEFGRGFTYNRPLRLNLLDLDYELAEQLDNIAEKACCGIPCKCSGQRGDRGPIGSIGPKGIPGEDGYRGYPGDEGGPGERGPPGVNGTQGFQGCPGQRGVKGSRGFPGEKGELGEIGLDGLDGEDGDKGLPGTSGEKGSPGRRGDKGPKGDKGERGDVGIRGDPGNSGQDSQQRGAKGETGDIGPVGLPGRDGVSGGPGEPGKSGGFGRRGPAGAKGNQGGPGQQGPVGEQGTRGAQGPPGPTGPPGLIGEQGIPGPRGGGGTAGAPGERGRTGPLGRKGEPGDPGPKGSIGNRGPRGETGDDGRDGVGSEGRIGKKGERGFPGYPGPKGNPGEPGTDGPPGPKGIRGRRGNSGPPGIAGQKGDPGYPGPSGYKGSRGDSMDQCALVQSIKDKCPCCYGPLECPVFPTELAFALDTSEGVTQDRFSQMREVVLKILDDLTIAESNCPRGARVAVVTYNNEVTTEIRFADSKKKSVLLDKIKNLQVSLTSKQQSLETAMSFVARNTFKRVRSGFLMRKVAVFFSNKPTRATPQLREAVLKLSDAGITPLFLTSQEDRQLINALQINNTAVGHALVLPAGGDLTDFLKNVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDSSESTTPFQFNEMRKYIEYLVRQLDVSPDPKASQHFARVAVVQHAPYEAVDNASVPPVKVEFSLTDYGSKEKLLAFLGSRMTQLQGTRALGRAIDYTIENIFESAPNPRDLKIVVLMLTGEVQKQQLEEAQRAILQAKCKGYFFVILGIGRKVNVKELYSSASEPNDVFFKLVDKSTELNEEPLMRFGRLLPSFVSSKDAFYLSPDIRKQCDWFQADQPAKNLVQFGYKQINVPNNVTSSPTSKLVTTTKPVITTTKPITVVNLPASKPAATRPVDERPAAGRSVATKMDSARPVATKTEATKPVATKTEATKTEAAKPVVTKAEAAKPTATKTEATKTEAAKLMATKTEATKPVAARPEAAKTATARPAAAAKPAAAKPAPARPPTAARSMATRSEAPRPQAVKLAASRPGAAKPVVKAPREIHVSEVTENSAKLHWERPEPPSPYLYNLTVTSAHDQAVVLKQNLTVTDRVIGGLLPGQTYHVTVTCSLRSQVRAIYQGSFSTKKIQPPPPQTERSASSATINLVVSADRLAGSKADICKLPKDGGTCREFVLKWYYDSVTENCARFWYGGCGGNENRFNSQDECEKVCPPVPIKQPGVIAAMGT", "length": 3025, "header": "tr|A0AAA9T393-1|E1BB91_BOVIN Computationally mapped isoform of Collagen alpha-3(VI) chain OS=Bos taurus OX=9913 GN=COL6A3 PE=1 SV=1 CANONICAL=E1BB91-1" }, "locus": { "chromosome": "3", "start_pos": 116855219, "end_pos": 116782468, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128902.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128902.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091095.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091095.1" } ] } }, { "isoform_ac": "A0AAA9TAB4-1", "url": "https://www.uniprot.org/uniprotkb/E1BB91/entry#A0AAA9TAB4-1", "sequence": { "sequence": "MRKHRHLPLVAILCLFFSGFSFTRGQQQPENYTSLHDIVGNLVACVRSSMAPERAGGTEIPKDITAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLERLSIGTQQIRVGVVQYSDEPRTMFSLNSYSTKAQVLDAVKALGFIGGELANVGLALDFVVENHFTRAGGSRAEEGVPQVLVLISAGPSSDEIRDGVVALKQASVFSFGLGAQAASKAELQHIATNDNLVFTVPEFRSLGDVQEQLLPYIVGVAQRHIVLQPPTIVTQVIEVNKRDIVFLVDGSSKLGLTNFNAIRDFIAKVIQRLEIRQDLIQVAVAQYADTVRPEFYFNTYPSKREVINAVRKMKALDGSALYTGSALDFVRNNLFTEAAGYRAAEGVPKLLVLVTGGKSLDAVSQPAQELKRSGILAFAVGNKVADQAELEEIAFDSSLVFTATEFRPAPLQGVLPGLLGPLRTLTGTTEVRVNKRDIIFLLDGSSNVGETNFPYVRDFVMNLVNSLDVGSDHIRVGLVQFSDTPVTEFSLNTYPTKSELLAHLRQMQLQGGSVLNTGAALSYVHANHFTEAGGSRIQDHVPQLLLLLTAGQSEDSYLQAANALARAGILTFCVGTSQADRAELEEIAFNPGLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLMGQFTAARDFLYKVIDELDVKPEGTRVAVAQFSDDVKVESRFDQHQNKPEILNLVKRMKLKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGKSSDRVDTPALNLKQSGVVPFILQAKNADPAELELIVPSPAFILVAESLPKIGDLQPQIVNLLKSVQNGAPAPVSVEKDVVFLIDGSEGVRSGFPLLKEFVQRVVESLDVGPDRVRVAVVQYSDRTRPEFYLNSYMDQQSVVGAIRGLTLLGGPAPNTGAALEFVLRNILVGSAGSRIAEGVPQLLIVLTADRSGDDVRGPSVVLRRGGAVPIGIGIGNADITEMQTLSFVPDFAVVIPTFRQLGTIQQVISERVTQLSREELSRLQASVTPLTTPVVSSKRDVVFLIDGSQSAGPEFQYIRTLIERLVDYLDVGFDTTRVAVIQFSDDPRVEFLLNVHSSKDEVQNAVRRLRPKGGRQVNVGGALEYVARNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVEDSAIELKQFGVAPLTIARNVDQEELVKISLSPEYVFSVNTFRELPSLEQKLLTPLTTLTAGQIQQLLASTRYPPPAVESDAADIVFLIDSSDGVKPDGIAHIRDFVIRIVRRLNVGPNKVRIGVLQFSNDVFPEFQLKTYKSQASVLDAIRRLRFKGGSPLNTGKALEFVARNYFVKSAGSRIEDGVPQHLVLFLGGKSQDDISRYSQVIKSAGIASLGVGDRNIDRTELQTITSDPRLVFTVREFRDLPSIEERMVNSFGSSGVTPAPPGVDTPSPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEGGDSIQVGLVQYNSDPTDEFFLKDFPTKQQIIDAINKVVYKGGRHANTKVGLEHLRRNHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQEASMALTQRGVKVFAVGVRNIDSEEVGKIASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDVSKACNLDVILGFDGSGDQNVFVAQKGLEPKVDTILRRISQMQKISCSGSQLPTVRVSVVALTPSGPVEAFDFAEYQPELFEKFQNMRAQHPYVLTADTLKLYQNKFRQASMDNVKVVIHFTDGVDGDLADLQRASEELRQEGVRALILVGLERVANLEQLMQLEFGRGFTYNRPLRLNLLDLDYELAEQLDNIAEKACCGIPCKCSGQRGDRGPIGSIGPKGIPGEDGYRGYPGDEGGPGERGPPGVNGTQGFQGCPGQRGVKGSRGFPGEKGELGEIGLDGLDGEDGDKGLPGTSGEKGSPGRRGDKGPKGDKGERGDVGIRGDPGNSGQDSQQRGAKGETGDIGPVGLPGRDGVSGGPGEPGKSGGFGRRGPAGAKGNQGGPGQQGPVGEQGTRGAQGPPGPTGPPGLIGEQGIPGPRGGGGTAGAPGERGRTGPLGRKGEPGDPGPKGSIGNRGPRGETGDDGRDGVGSEGRIGKKGERGFPGYPGPKGNPGEPGTDGPPGPKGIRGRRGNSGPPGIAGQKGDPGYPGPSGYKGSRGDSMDQCALVQSIKDKCPCCYGPLECPVFPTELAFALDTSEGVTQDRFSQMREVVLKILDDLTIAESNCPRGARVAVVTYNNEVTTEIRFADSKKKSVLLDKIKNLQVSLTSKQQSLETAMSFVARNTFKRVRSGFLMRKVAVFFSNKPTRATPQLREAVLKLSDAGITPLFLTSQEDRQLINALQINNTAVGHALVLPAGGDLTDFLKNVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDSSESTTPFQFNEMRKYIEYLVRQLDVSPDPKASQHFARVAVVQHAPYEAVDNASVPPVKVEFSLTDYGSKEKLLAFLGSRMTQLQGTRALGRAIDYTIENIFESAPNPRDLKIVVLMLTGEVQKQQLEEAQRAILQAKCKGYFFVILGIGRKVNVKELYSSASEPNDVFFKLVDKSTELNEEPLMRFGRLLPSFVSSKDAFYLSPDIRKQCDWFQADQPAKNLVQFGYKQINVPNNVTSSPTSKLVTTTKPVITTTKPITVVNLPASKPAATRPVDERPAAGRSVATKMDSARPVATKTEATKPVATKTEATKTEAAKPVVTKAEAAKPTATKTEATKTEAAKLMATKTEATKPVAARPEAAKTATARPAAAAKPAAAKPAPARPPTAARSMATRSEAPRPQAVKLAASRPGAAKPVVKAPREIHVSEVTENSAKLHWERPEPPSPYLYNLTVTSAHDQAVVLKQNLTVTDRVIGGLLPGQTYHVTVTCSLRSQVRAIYQGSFSTKKIQPPPPQTERSASSATINLVVSADRLAGSKADICKLPKDGGTCREFVLKWYYDSVTENCARFWYGGCGGNENRFNSQDECEKVCPPVPIKQPGVIAAMGT", "length": 3061, "header": "tr|A0AAA9TAB4-1|E1BB91_BOVIN Computationally mapped isoform of Collagen alpha-3(VI) chain OS=Bos taurus OX=9913 GN=COL6A3 PE=1 SV=1 CANONICAL=E1BB91-1" }, "locus": { "chromosome": "3", "start_pos": 116855219, "end_pos": 116782468, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118734.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118734.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094962.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094962.1" } ] } }, { "isoform_ac": "E1BB91-1", "url": "https://www.uniprot.org/uniprotkb/E1BB91/entry#E1BB91-1", "sequence": { "sequence": "MRKHRHLPLVAILCLFFSGFSFTRGQQQPDVKNGAAADIIFLVDSSWSIGKEHFQLVREFLYDVIESLAVGDNDFRFALVQFNGNPHTEFLFNTYRSKQEVLSHVSNMSYIGGSNQTGKGLAYVMQNHLTEAAGSRASDGVPQVIVVLTHGHSEDGLALPSAELKSADVNVFAIGVEDADEAALKEIASEPLNMHVFNLENYTSLHDIVGNLVACVRSSMAPERAGGTEIPKDITAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLERLSIGTQQIRVGVVQYSDEPRTMFSLNSYSTKAQVLDAVKALGFIGGELANVGLALDFVVENHFTRAGGSRAEEGVPQVLVLISAGPSSDEIRDGVVALKQASVFSFGLGAQAASKAELQHIATNDNLVFTVPEFRSLGDVQEQLLPYIVGVAQRHIVLQPPTIVTQVIEVNKRDIVFLVDGSSKLGLTNFNAIRDFIAKVIQRLEIRQDLIQVAVAQYADTVRPEFYFNTYPSKREVINAVRKMKALDGSALYTGSALDFVRNNLFTEAAGYRAAEGVPKLLVLVTGGKSLDAVSQPAQELKRSGILAFAVGNKVADQAELEEIAFDSSLVFTATEFRPAPLQGVLPGLLGPLRTLTGTTEVRVNKRDIIFLLDGSSNVGETNFPYVRDFVMNLVNSLDVGSDHIRVGLVQFSDTPVTEFSLNTYPTKSELLAHLRQMQLQGGSVLNTGAALSYVHANHFTEAGGSRIQDHVPQLLLLLTAGQSEDSYLQAANALARAGILTFCVGTSQADRAELEEIAFNPGLVYLMDDFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLMGQFTAARDFLYKVIDELDVKPEGTRVAVAQFSDDVKVESRFDQHQNKPEILNLVKRMKLKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGKSSDRVDTPALNLKQSGVVPFILQAKNADPAELELIVPSPAFILVAESLPKIGDLQPQIVNLLKSVQNGAPAPVSVEKDVVFLIDGSEGVRSGFPLLKEFVQRVVESLDVGPDRVRVAVVQYSDRTRPEFYLNSYMDQQSVVGAIRGLTLLGGPAPNTGAALEFVLRNILVGSAGSRIAEGVPQLLIVLTADRSGDDVRGPSVVLRRGGAVPIGIGIGNADITEMQTLSFVPDFAVVIPTFRQLGTIQQVISERVTQLSREELSRLQASVTPLTTPVVSSKRDVVFLIDGSQSAGPEFQYIRTLIERLVDYLDVGFDTTRVAVIQFSDDPRVEFLLNVHSSKDEVQNAVRRLRPKGGRQVNVGGALEYVARNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVEDSAIELKQFGVAPLTIARNVDQEELVKISLSPEYVFSVNTFRELPSLEQKLLTPLTTLTAGQIQQLLASTRYPPPAVESDAADIVFLIDSSDGVKPDGIAHIRDFVIRIVRRLNVGPNKVRIGVLQFSNDVFPEFQLKTYKSQASVLDAIRRLRFKGGSPLNTGKALEFVARNYFVKSAGSRIEDGVPQHLVLFLGGKSQDDISRYSQVIKSAGIASLGVGDRNIDRTELQTITSDPRLVFTVREFRDLPSIEERMVNSFGSSGVTPAPPGVDTPSPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEGGDSIQVGLVQYNSDPTDEFFLKDFPTKQQIIDAINKVVYKGGRHANTKVGLEHLRRNHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQEASMALTQRGVKVFAVGVRNIDSEEVGKIASNSATAFRVGNVQELSELSEQVLETLHDAMHETLCPGVTDVSKACNLDVILGFDGSGDQNVFVAQKGLEPKVDTILRRISQMQKISCSGSQLPTVRVSVVALTPSGPVEAFDFAEYQPELFEKFQNMRAQHPYVLTADTLKLYQNKFRQASMDNVKVVIHFTDGVDGDLADLQRASEELRQEGVRALILVGLERVANLEQLMQLEFGRGFTYNRPLRLNLLDLDYELAEQLDNIAEKACCGIPCKCSGQRGDRGPIGSIGPKGIPGEDGYRGYPGDEGGPGERGPPGVNGTQGFQGCPGQRGVKGSRGFPGEKGELGEIGLDGLDGEDGDKGLPGTSGEKGSPGRRGDKGPKGDKGERGDVGIRGDPGNSGQDSQQRGAKGETGDIGPVVQCSPFLPVQSNLPLCGSCGGRGGSPPRSTYVGILLLQGPPGPTGPPGLIGEQGIPGPRVSLAWTLSKSGEPGDPGPKGSIGNRGPRGETGDDGRDGVGSEGRIGKKVFICRGGNPGEPGTDGPPGPKGIRGRRGNSGPPGIAGQKGDPGYPGPSGYKGSRGDSMDQCALVQSIKDKCRPLECPVFPTELAFALDTSEGVTQDRFSQMREVVLKILDDLTIAESNCPRGARVAVVTYNNEVTTEIRFADSKKKSVLLDKIKNLQVSLTSKQQSLETAMSFVARNTFKRVRSGFLMRKVAVFFSNKPTRATPQLREAVLKLSDAGITPLFLTSQEDRQLINALQINNTAVGHALVLPAGGDLTDFLKNVLTCHVCLDICNIDPSCGFGSWRPSFRDRRAAGSDVDIDMAFILDSSESTTPFQFNEMRKYIEYLVRQLDVSPDPKASQHFARVAVVQHAPYEAVDNASVPPVKVEFSLTDYGSKEKLLAFLGSRMTQLQGTRALGRAIDYTIENIFESAPNPRDLKIVVLMLTGEVQKQQLEEAQRAILQAKCKGYFFVILGIGRKVNVKELYSSASEPNDVFFKLVDKSTELNEEPLMRFGRLLPSFVSSKDAFYLSPDIRKQCDWFQADQPAKNLVQFGYKQINVPNNVTSSPTSKLVTTTKPVITTTKPITVVNLPASKPAATRPVDERPAAGRSVATKMDSARPVATKTEATKPAAAAKPAAAKPAPARPPTAARSMATRSEAPRPQAVKLAASRPGAAKPVVKAPREIHVSEVTENSAKLHWERPEPPSPYLYNLTVTSAHDQAVVLKQNLTVTDRVIGGLLPGQTYHVTVTCSLRSQVRAIYQGSFSTKKIQPPPPQTERSASSATINLVVSADRLAGSKADICKLPKDGGTCREFVLKWYYDSVTENCARFWYGGCGGNENRFNSQDECEKVCPPVPIKQPGVIAAMGT", "length": 3132, "header": "tr|E1BB91-1|E1BB91_BOVIN Isoform 1 of Collagen alpha-3(VI) chain OS=Bos taurus OX=9913 GN=COL6A3 PE=1 SV=3 CANONICAL=E1BB91-1" }, "locus": { "chromosome": "3", "start_pos": 116855219, "end_pos": 116782468, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018479.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018479.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018479.7", "url": "https://www.ensembl.org/id/ENSBTAP00000018479.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1618, "start_aa": "Thr", "end_pos": 1618, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1618", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2222, "start_aa": "Thr", "end_pos": 2222, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2222", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true }, "site_seq": "N", "relation": "attached", "comment": "reported site N2387 is on non-canonical isoform A0AAA9TAB4-1 which maps to canonical isoform site E1BB91-1:2523", "icn3d_view": { "label": "iCn3D", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?bcifid=9HAN&bu=0&command=select+.F:2387;+center+selection;+zoom+selection" }, "start_pos": 2523, "start_aa": "Asn", "end_pos": 2523, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn2523", "evidence": [ { "id": "9HAN", "database": "PDB", "url": "https://www.rcsb.org/structure/9HAN" }, { "id": "9HAN", "database": "PDB", "url": "https://www.rcsb.org/structure/9HAN" }, { "id": "9HAN|F|2387", "database": "", "url": "" }, { "id": "9HAN|C|2387", "database": "", "url": "" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted", "glycoprotein_reported" ], "publication": [ { "title": "Collagen VI microfibril structure reveals mechanism for molecular assembly and clustering of inherited pathogenic mutations.", "journal": "Nat. Commun.", "date": "2025", "authors": "Dajani R., Baldock C., Roseman A.M., Becker M.H., Godwin A.R.F., Snee M.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAB4" } ], "reference": [ { "type": "PubMed", "id": "40813585", "url": "https://glygen.org/publication/PubMed/40813585" } ] } ], "pathway": [ { "id": "R-BTA-1442490", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1442490", "resource": "Reactome", "description": "Collagen degradation" }, { "id": "R-BTA-1650814", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1650814", "resource": "Reactome", "description": "Collagen biosynthesis and modifying enzymes" }, { "id": "R-BTA-186797", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-186797", "resource": "Reactome", "description": "Signaling by PDGF" }, { "id": "R-BTA-2022090", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022090", "resource": "Reactome", "description": "Assembly of collagen fibrils and other multimeric structures" }, { "id": "R-BTA-216083", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216083", "resource": "Reactome", "description": "Integrin cell surface interactions" }, { "id": "R-BTA-3000178", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3000178", "resource": "Reactome", "description": "ECM proteoglycans" }, { "id": "R-BTA-8948216", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948216", "resource": "Reactome", "description": "Collagen chain trimerization" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "E1BB91", "url": "https://www.uniprot.org/uniprotkb/E1BB91" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "E1BB91", "url": "https://www.uniprot.org/uniprotkb/E1BB91" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "collagen type VI trimer", "id": "GO:0005589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005589", "evidence": [ { "database": "UniProtKB", "id": "E1BB91", "url": "https://www.uniprot.org/uniprotkb/E1BB91" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 115, "end_pos": 117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 201, "end_pos": 203, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2078, "end_pos": 2080, "annotation": "n_glycosylation_sequon" }, { "start_pos": 250, "end_pos": 252, "annotation": 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], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "E1BBT0-1", "uniprot_ac": "E1BBT0", "uniprot_id": "E1BBT0_BOVIN", "mass": { "chemical_mass": 37510.0, "monoisotopic_mass": 37510.0 }, "refseq": { "ac": "NP_001179287", "name": "aldo-keto reductase family 1 member D1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179287" }, "gene_names": [ { "name": "AKR1D1", "type": "recommended", "evidence": [ { "id": 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"database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513855", "url": "https://www.ncbi.nlm.nih.gov/gene/513855", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020471", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020471", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036812", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036812", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513855", "url": 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"Enzyme and Pathway" ] }, { "id": "R-BTA-193807", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-193807", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179287", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SVK4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVK4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVK4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTL6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTL6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBT0", "url": "https://www.uniprot.org/uniprotkb/E1BBT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBT0-1", "url": "https://www.uniprot.org/uniprotkb/E1BBT0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHLSAVYHRIPLSDGNSIPIIGLGTYSEPKSTPKGTCATSVKIAIDTGYRHIDGAYLYQNEHEVGEAIREKIAEGKVQREDIFYCGKLWATNLDPELVRPTLERTLKDLQLDYVDLYIIEIPMAFKPGDDFYPRDENGKWLYHKSNLCATWEALEACKDAGLVKSLGVSNFNRRQLELILNKPGLKYKPVSNQVECHPYFTQPKLLKFCQQHDIVIVAYSPLGTCRNPSWVNVSSPPLLKDPFLNALGKKYNKTAAQVVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSFTEEEMKDIEALNKNIRFVEMLMWCDHPEYPFHDEY", "length": 326, "header": "tr|E1BBT0-1|E1BBT0_BOVIN Isoform 1 of Aldo-keto reductase family 1 member D1 OS=Bos taurus OX=9913 GN=AKR1D1 PE=3 SV=1 CANONICAL=E1BBT0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVK4-1", "url": "https://www.uniprot.org/uniprotkb/E1BBT0/entry#A0AAA9SVK4-1", "sequence": { "sequence": 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"MHLSAVYHRIPLSDGNSIPIIGLGTYSEPKSTPKGTCATSVKIAIDTGYRHIDGAYLYQNEHEVGEAIREKIAEGKVQREDIFYCGKLWATNLDPELVRPTLERTLKDLQLDYVDLYIIEIPMAFKPGDDFYPRDENGKWLYHKSNLCATWEALEACKDAGLVKSLGVSNFNRRQLELILNKPGLKYKPVSNQVECHPYFTQPKLLKFCQQHDIVIVAYSPLGTCRNPSWVNVSSPPLLKDPFLNALGKKYNKTAAQVVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSFTEEEMKDIEALNKNIRFVEMLIPIYRTPAGEPKMGRGRNLSLPIRLLNCGVREDS", "length": 346, "header": "tr|A0AAA9TTL6-1|E1BBT0_BOVIN Computationally mapped isoform of Aldo-keto reductase family 1 member D1 OS=Bos taurus OX=9913 GN=AKR1D1 PE=3 SV=1 CANONICAL=E1BBT0-1" }, "locus": { "chromosome": "4", "start_pos": 101839088, "end_pos": 101778335, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097504.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097504.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100417.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100417.1" } ] } }, { "isoform_ac": "E1BBT0-1", "url": "https://www.uniprot.org/uniprotkb/E1BBT0/entry#E1BBT0-1", "sequence": { "sequence": "MHLSAVYHRIPLSDGNSIPIIGLGTYSEPKSTPKGTCATSVKIAIDTGYRHIDGAYLYQNEHEVGEAIREKIAEGKVQREDIFYCGKLWATNLDPELVRPTLERTLKDLQLDYVDLYIIEIPMAFKPGDDFYPRDENGKWLYHKSNLCATWEALEACKDAGLVKSLGVSNFNRRQLELILNKPGLKYKPVSNQVECHPYFTQPKLLKFCQQHDIVIVAYSPLGTCRNPSWVNVSSPPLLKDPFLNALGKKYNKTAAQVVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSFTEEEMKDIEALNKNIRFVEMLMWCDHPEYPFHDEY", "length": 326, "header": "tr|E1BBT0-1|E1BBT0_BOVIN Isoform 1 of Aldo-keto reductase family 1 member D1 OS=Bos taurus OX=9913 GN=AKR1D1 PE=3 SV=1 CANONICAL=E1BBT0-1" }, "locus": { "chromosome": "4", "start_pos": 101828540, "end_pos": 101778335, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002172.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002172.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002172.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002172.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513855", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513855", "resource": "KEGG Pathway" }, { "id": "R-BTA-193368", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-193368", "resource": "Reactome", "description": "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" }, { "id": "R-BTA-193775", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-193775", "resource": "Reactome", "description": "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" }, { "id": "R-BTA-193807", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-193807", "resource": "Reactome", "description": "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2L9N6-1", "protein_name": "Aldo-keto reductase family 1 member D1 isoform X1", "gene_name": "Akr1d1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNLSATNHQIPLSDGNSIPVIGLGTYSDPRPVPRETYMAVKMAIDQGYRHFDGAYLYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWATDHLPERVRPALERTLQSLKLDYVDLYIIEIPMAFKPGMQEYPRDENGQWLYHKSDLCATWEALEACKDAGLVKSLGVSNFNRRQLELILNKPGLKYKPVSNQVECHPYFTQPKLLKFCQQHDIVIVAYSPLGTCRNPSWVNVSSPSLLKDKLLNSLGKRYNKTAAQIGLRFNIQRGVVVIPKSFNPQRMKENFQIFDFSLTEEEMKDIEALNKNVRFVELLMWSDHPEYPFHDEY", "length": 325 }, "evidence": [ { "id": "E1BBT0", "url": "https://omabrowser.org/oma/group/E1BBT0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1SNJ5-1", "protein_name": "Aldo-keto reductase family 1 member D1", "gene_name": "AKR1D1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MYLSAAHHRIPLNDGNSIPIIGLGTFSEPKLTPKGICGTSVKIAIDTGYRHIDGAFIYQNEHEVGEAIREKIAEGKVRREDIFYCGKLWATNLDPEMVRPALERTLKVLQLDYVDLYIIEVPMAFKPGDDNFPKDENGKWLYCKSNLCGTWEALEACKDDGLVKSLGVSNFNRRQLELILNKPGLKYKPVSNQVECHPYFTQQKLLKFCQQHDIVIIAYSPLGTSRNPSWVNVSSPPLLKDELLNSLGKKYNKTAAQVVLRFSIQRGVVVIPKSFTPERIKENFQIFDFSLTEDEMKDIEALNKNVRFVEMLMWRDHPEYPFHDEY", "length": 326 }, "evidence": [ { "id": "E1BBT0", "url": "https://omabrowser.org/oma/group/E1BBT0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P31210-1", "protein_name": "Aldo-keto reductase family 1 member D1", "gene_name": "Akr1d1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNLSTANHHIPLNDGNSIPIIGLGTYSDPRPVPGKTFIAVKTAIDEGYRHIDGAYVYRNEHEVGEAIREKVAEGKVKREEIFYCGKLWSTDHDPEMVRPALERTLQTLKLDYIDLYIIEMPMAFKPGEEFYPKDENGRVIYHKSNLCATWEALEACKDAGLVKSLGVSNFNRRQLEVILNKPGLKYKPVTNQVECHPYFTQTKLLEVSASSMTSFIVAYSPLGTCRNPLWVNVSSPPLLKDELLTSLGKKYNKTQAQIVLRFDIQRGLVVIPKSTTPERIKENFQIFDFSLTKEEMKDIEALNKNVRFVEMLMWSDHPEYPFHDEY", "length": 326 }, "evidence": [ { "id": "E1BBT0", "url": "https://omabrowser.org/oma/group/E1BBT0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P51857-1", "protein_name": "Aldo-keto reductase family 1 member D1", "gene_name": "AKR1D1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFVELLMWRDHPEYPFHDEY", "length": 326 }, "evidence": [ { "id": "E1BBT0", "url": "https://omabrowser.org/oma/group/E1BBT0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VCX1-1", "protein_name": "Aldo-keto reductase family 1 member D1", "gene_name": "Akr1d1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNLSAAHHQISLSDGNNIPLIGLGTYSDPRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFKPGKEIYPRDENGRIIYDKTNLCATWEALEACKDAGLVKSLGVSNFNRRQLELILNKPGLKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRNPSWVNVSSPPLLNDELLTSLGKKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRYVELLMWSDHPEYPFHDEY", "length": 325 }, "evidence": [ { "id": "E1BBT0", "url": "https://omabrowser.org/oma/group/E1BBT0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "E1BBT0", "url": "https://www.uniprot.org/uniprotkb/E1BBT0" } ], "pmid": "" }, { "name": "Delta4-3-oxosteroid 5beta-reductase activity", "id": "GO:0047787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047787", "evidence": [ { "database": "UniProtKB", "id": "E1BBT0", "url": "https://www.uniprot.org/uniprotkb/E1BBT0" } ], "pmid": "" }, { "name": "steroid dehydrogenase activity", "id": "GO:0016229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016229", "evidence": [ { "database": "UniProtKB", "id": "E1BBT0", "url": "https://www.uniprot.org/uniprotkb/E1BBT0" } ], "pmid": "" }, { "name": "aldose reductase (NADPH) activity", "id": "GO:0004032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004032", "evidence": [ { "database": "UniProtKB", "id": "E1BBT0", "url": "https://www.uniprot.org/uniprotkb/E1BBT0" } ], "pmid": "" }, { "name": "ketosteroid monooxygenase activity", "id": "GO:0047086", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047086", "evidence": [ { "database": "UniProtKB", "id": "E1BBT0", "url": "https://www.uniprot.org/uniprotkb/E1BBT0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BBT0", "url": "https://www.uniprot.org/uniprotkb/E1BBT0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "bile acid biosynthetic process", "id": "GO:0006699", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006699", "evidence": [ { "database": "UniProtKB", "id": "E1BBT0", "url": "https://www.uniprot.org/uniprotkb/E1BBT0" } ], "pmid": "" }, { "name": "digestion", "id": "GO:0007586", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007586", "evidence": [ { "database": "UniProtKB", "id": "E1BBT0", "url": "https://www.uniprot.org/uniprotkb/E1BBT0" } ], "pmid": "" }, { "name": "cholesterol catabolic process", "id": "GO:0006707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006707", "evidence": [ { "database": "UniProtKB", "id": "E1BBT0", "url": "https://www.uniprot.org/uniprotkb/E1BBT0" } ], "pmid": "" }, { "name": "C21-steroid hormone metabolic process", "id": "GO:0008207", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008207", "evidence": [ { "database": "UniProtKB", "id": "E1BBT0", "url": "https://www.uniprot.org/uniprotkb/E1BBT0" } ], "pmid": "" }, { "name": "androgen metabolic process", "id": "GO:0008209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008209", "evidence": [ { "database": "UniProtKB", "id": "E1BBT0", "url": "https://www.uniprot.org/uniprotkb/E1BBT0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 232, "end_pos": 234, "annotation": "n_glycosylation_sequon" }, { "start_pos": 252, "end_pos": 254, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBT0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 326, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBT0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBT0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBT0" }, { "id": "PF00248", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00248" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NADP-dependent oxidoreductase", "eco_id": "ECO_0000259", "start_pos": 21, "end_pos": 303, "start_aa": "Ile", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 232, "end_pos": 234 }, { "start_pos": 252, "end_pos": 254 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BAN3-1", "uniprot_ac": "E1BAN3", "uniprot_id": "E1BAN3_BOVIN", "mass": { "chemical_mass": 82347.0, "monoisotopic_mass": 82347.0 }, "refseq": {}, "gene_names": [ { "name": "TRPV6", "type": "recommended", "evidence": [ { "id": "E1BAN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN3" } ] } ], "protein_names": [ { "name": "Transient receptor potential cation channel subfamily V member 6", "type": "recommended", "evidence": [ { "id": "E1BAN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN3/entry#names_and_taxonomy" } ] }, { "name": "Calcium transport protein 1", "type": "synonym", "evidence": [ { "id": "E1BAN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN3/entry#names_and_taxonomy" } ] }, { "name": "Epithelial calcium channel 2", "type": "synonym", "evidence": [ { "id": "E1BAN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine. Important for normal Ca(2+) ion homeostasis in the body, including bone and skin. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.", "evidence": [ { "database": "UniProtKB", "id": "E1BAN3", "url": "https://www.uniprot.org/uniprotkb/E1BAN3#function" }, { "database": "UniProtKB", "id": "ARBA00054373", "url": "https://www.uniprot.org/uniprotkb/ARBA00054373#function" } ] }, { "annotation": "Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY85#function" }, { "database": "UniProtKB", "id": "ARBA00058261", "url": "https://www.uniprot.org/uniprotkb/ARBA00058261#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAN3", "url": "https://www.uniprot.org/uniprotkb/E1BAN3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRPV6", "url": "https://www.uniprot.org/uniprotkb/E1BAN3", "locus": { "chromosome": "4", "start_pos": 106181051, "end_pos": 106199616, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024219", "url": "https://www.ensembl.org/id/ENSBTAG00000024219" } ] } } ], "crossref": [ { "id": "E1BAN3", "url": "https://alphafold.ebi.ac.uk/entry/E1BAN3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024219", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024219", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22192", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22192", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614878", "url": "https://www.ncbi.nlm.nih.gov/gene/614878", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008344", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008344", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008345", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008345", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024862", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024862", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614878", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614878", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LCLWNKF", "url": "https://omabrowser.org/oma/group/LCLWNKF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAN3", "url": "https://www.orthodb.org/?gene=E1BAN3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10582", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10582", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10582:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10582:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3295583", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3295583", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "29671", "url": "https://www.rhea-db.org/rhea/29671", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SY85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY85-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAN3", "url": "https://www.uniprot.org/uniprotkb/E1BAN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAN3-1", "url": "https://www.uniprot.org/uniprotkb/E1BAN3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLPLPKEKGHILCLWRKLCRWFQRQEPWAQRRDEQNLLQQRRIWESPLLLAAKENDIQALSKLLKYEACDVHQKGAMGETALHVAALYDNLEAATVLMEAAPELVKEPMTSELYEGQTALHIAVMNRNVNLVKALLAHGASVSARAIGSAFRLTPHNLIYFGEHPLSFAACMGSEEIVRLLIKHGADIRAQDSLGNTVLHILVLQPNKTFACQMYNLLLSYDRRGDHLQSLDLMLNHQGLTPFKLAGVEGNTVMFQNLVQKQKYIQWTCGPLTSTLYDLTEIDSSGEELSLLELIVTSKKREARQILDQTPVKELVTLKWKRYGRPYFCVLAAMYLLYIVCFTMCCVYRPLKPRTDNETDPRDNTIWEQKPLQEAYVTHQDHLRLVGELVSIFGAVIILFIEITDIFRVGLSRVFGQTILGGPFHVLFITYSCMVLVTMVMRLTNTSGEVVPMSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFFIIFQTEDPNELGHFYSYPMALFSTFELFLTIIDGPANYDVDLPFMYSITYAAFAIIAALLMLNLLIAMMGDTHWRVAHERDELWRAQVVATTVMLEKKLPRCLWPRSGICGHKFGLGDRWFLRVEEKQDINQQRVRRYAQAFCHPGSEDDTERLWLGGPFGTHLSLLTPSVSRSTSRSSINWERLRQGTLKRELRGVVNKALEDGEGWEYQI", "length": 721, "header": "tr|E1BAN3-1|E1BAN3_BOVIN Isoform 1 of Transient receptor potential cation channel subfamily V member 6 OS=Bos taurus OX=9913 GN=TRPV6 PE=3 SV=2 CANONICAL=E1BAN3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SY85-1", "url": "https://www.uniprot.org/uniprotkb/E1BAN3/entry#A0AAA9SY85-1", "sequence": { "sequence": "MHLSWARGETKQNHACGAERSRDTLRERIWESPLLLAAKENDIQALSKLLKYEACDVHQKGAMGETALHVAALYDNLEAATVLMEAAPELVKEPMTSELYEGQTALHIAVMNRNVNLVKALLAHGASVSARAIGSAFRLTPHNLIYFGEHPLSFAACMGSEEIVRLLIKHGADIRAQDSLGNTVLHILVLQPNKTFACQMYNLLLSYDRRGDHLQSLDLMLNHQGLTPFKLAGVEGNTVMFQNLVQKQKYIQWTCGPLTSTLYDLTEIDSSGEELSLLELIVTSKKREARQILDQTPVKELVTLKWKRYGRPYFCVLAAMYLLYIVCFTMCCVYRPLKPRTDNETDPRDNTIWEQKPLQEAYVTHQDHLRLVGELVSIFGAVIILFIEITDIFRVGLSRVFGQTILGGPFHVLFITYSCMVLVTMVMRLTNTSGEVVPMSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFFIIFQTEDPNELGHFYSYPMALFSTFELFLTIIDGPANYDVDLPFMYSITYAAFAIIAALLMLNLLIAMMGDTHWRVAHERDELWRAQVVATTVMLEKKLPRCLWPRSGICGHKFGLGDRWFLRVEEKQDINQQRVRRYAQAFCHPGSEDDTERLWLGGPFGTHLSLLTPSVSRSTSRSSINWERLRQGTLKRELRGVVNKALEDGEGWEYQI", "length": 706, "header": "tr|A0AAA9SY85-1|E1BAN3_BOVIN Computationally mapped isoform of Transient receptor potential cation channel subfamily V member 6 OS=Bos taurus OX=9913 GN=TRPV6 PE=3 SV=1 CANONICAL=E1BAN3-1" }, "locus": { "chromosome": "4", "start_pos": 106198289, "end_pos": 106181421, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127182.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127182.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088288.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088288.1" } ] } }, { "isoform_ac": "E1BAN3-1", "url": "https://www.uniprot.org/uniprotkb/E1BAN3/entry#E1BAN3-1", "sequence": { "sequence": "MGLPLPKEKGHILCLWRKLCRWFQRQEPWAQRRDEQNLLQQRRIWESPLLLAAKENDIQALSKLLKYEACDVHQKGAMGETALHVAALYDNLEAATVLMEAAPELVKEPMTSELYEGQTALHIAVMNRNVNLVKALLAHGASVSARAIGSAFRLTPHNLIYFGEHPLSFAACMGSEEIVRLLIKHGADIRAQDSLGNTVLHILVLQPNKTFACQMYNLLLSYDRRGDHLQSLDLMLNHQGLTPFKLAGVEGNTVMFQNLVQKQKYIQWTCGPLTSTLYDLTEIDSSGEELSLLELIVTSKKREARQILDQTPVKELVTLKWKRYGRPYFCVLAAMYLLYIVCFTMCCVYRPLKPRTDNETDPRDNTIWEQKPLQEAYVTHQDHLRLVGELVSIFGAVIILFIEITDIFRVGLSRVFGQTILGGPFHVLFITYSCMVLVTMVMRLTNTSGEVVPMSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFFIIFQTEDPNELGHFYSYPMALFSTFELFLTIIDGPANYDVDLPFMYSITYAAFAIIAALLMLNLLIAMMGDTHWRVAHERDELWRAQVVATTVMLEKKLPRCLWPRSGICGHKFGLGDRWFLRVEEKQDINQQRVRRYAQAFCHPGSEDDTERLWLGGPFGTHLSLLTPSVSRSTSRSSINWERLRQGTLKRELRGVVNKALEDGEGWEYQI", "length": 721, "header": "tr|E1BAN3-1|E1BAN3_BOVIN Isoform 1 of Transient receptor potential cation channel subfamily V member 6 OS=Bos taurus OX=9913 GN=TRPV6 PE=3 SV=2 CANONICAL=E1BAN3-1" }, "locus": { "chromosome": "4", "start_pos": 106197650, "end_pos": 106181421, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033438.4", "url": "https://www.ensembl.org/id/ENSBTAT00000033438.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033351.4", "url": "https://www.ensembl.org/id/ENSBTAP00000033351.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614878", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614878", "resource": "KEGG Pathway" }, { "id": "R-BTA-3295583", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3295583", "resource": "Reactome", "description": "TRP channels" } ], "orthologs": [ { "uniprot_canonical_ac": "Q91WD2-1", "protein_name": "Transient receptor potential cation channel subfamily V member 6", "gene_name": "Trpv6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"https://www.ebi.ac.uk/interpro/entry/pfam/PF02862", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24694", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24694", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24695", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24695", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1483226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SZJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { 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"length": 1207, "header": "tr|A0AAA9SZJ5-1|E1B9I9_BOVIN Computationally mapped isoform of Phosphatidylinositol transfer protein membrane associated 1 OS=Bos taurus OX=9913 GN=PITPNM1 PE=3 SV=1 CANONICAL=E1B9I9-1" }, "locus": { "chromosome": "29", "start_pos": 45386038, "end_pos": 45373824, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116113.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116113.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089719.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089719.1" } ] } }, { "isoform_ac": "A0AAA9TJJ3-1", "url": "https://www.uniprot.org/uniprotkb/E1B9I9/entry#A0AAA9TJJ3-1", "sequence": { "sequence": "MLIKEYHILLPMSLDEYQVAQLYMIQKKSREESSGEGSGVEILANRPYTDGPGGSGQYTHKVYHVGSHIPGWFRALLPKAALQVEEESWNAYPYTRTRYTCPFVEKFSIEIETYYLPDGGQQPNVFNLSGAERRQRILDTIDIVRDAVAPGEYKAEEDPRLYRSAKTGRGPLADDWARTAAQTGPLMCAYKLCKVEFRYWGMQAKIEQFIHDVGLRRVMLRAHRQAWCWQDEWTELSMADIRALEEETARMLAQRMAKCNTGSEGPEAQPPGKPSSEARAGASHAGTPDGPEAPPGPDASPDASFSKQWSSSSRSSYSSQHGGGVSPQTLSEWRMQNIARDSENSSEEEFFDAHEGFSDSDEVFPKEMTKWNSNDFIDAFASPMEAEGTPDPGTEGTKDLGDGARAPRDSEGPDGDSAGELGAETCEVHALFLVLHSGSILDSGPGDADSKRADVQTLSLAFEAVTRVHFPEALGHVALRLVPCPPICAAAYALVSNLSPYSHDGDSLSRSQDHIPLAALPLLATSSSRYQGAVATVIARTNQAYAAFLRSSEGAGFCGQVVLIGDGVGGILGFDALCHSASVGTGSRSSSRRGSMNNELLSPEAGPMRDPLAEGAEGLGRASPEPSALPTQRTPSDMAGPEPEGSQNSLQAAPPATSSGEPRRASTASCPPTATSEAPDSAPCAARLDFKVSGFFLFGSPLGLVLALRKTVMPTLEVAQMRPACEQIYNLFHAADPCASRLEPLLAPKFQAIAPLAVPRYQKFPLGDGSSLLLADTLQTHSGLFLEELEMLVPSTPTSASGAFWKGNELGGDPPAQPTAPSTTSEVVKILERWWGTKRIDYSLYCPEALTAFPTVTLPHLFHASYWESADVVAFILRQVIEKERPHLTECEEPSIYSPAFPREKWQRKRTQVKIRPLHRVYIASAPWNRSPHRGPPGPLIGNVTSNHRASDTVVCEGRPQVLNGRFMYGPLDVVTLTGEKVDIYIMTQPLSGKWIHFGTEVTNSSGRLTFPVPLERALGVGVYPVRMVVRGDHTYAECCLTVVARGTEAVVFSIDGSFTASVSIMGSDPKVRAGAVDVVRHWQDAGYLIVYVTGRPDMQKHRVVAWLSQHNFPHGVVSFCDGLTHDPLRQKAMFLQSLVQEVELNFVAAYGSPKDVAVYAALGLPPSQTYIVGRAVRKLQAQCQFLSDGYVAHLGQLEAGSHPHATSGPSRAALAKSSYGGAAPVDFLRKQSQLLRSRGPSQAEREGPGTPPTTLARGKARSISLKLDSEE", "length": 1272, "header": "tr|A0AAA9TJJ3-1|E1B9I9_BOVIN Computationally mapped isoform of Phosphatidylinositol transfer protein membrane associated 1 OS=Bos taurus OX=9913 GN=PITPNM1 PE=3 SV=1 CANONICAL=E1B9I9-1" }, "locus": { "chromosome": "29", "start_pos": 45386038, "end_pos": 45373824, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092920.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092920.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096417.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096417.1" } ] } }, { "isoform_ac": "E1B9I9-1", "url": "https://www.uniprot.org/uniprotkb/E1B9I9/entry#E1B9I9-1", "sequence": { "sequence": "MLIKEYHILLPMSLDEYQVAQLYMIQKKSREESSGEGSGVEILANRPYTDGPGGSGQYTHKVYHVGSHIPGWFRALLPKAALQVEEESWNAYPYTRTRYTCPFVEKFSIEIETYYLPDGGQQPNVFNLSGAERRQRILDTIDIVRDAVAPGEYKAEEDPRLYRSAKTGRGPLADDWARTAAQTGPLMCAYKLCKVEFRYWGMQAKIEQFIHDVGLRRVMLRAHRQAWCWQDEWTELSMADIRALEEETARMLAQRMAKCNTGSEGPEAQPPGKPSSEARAGASHAGTPDGPEAPPGPDASPDASFSKQWSSSSRSSYSSQHGGGVSPQTLSEWRMQNIARDSENSSEEEFFDAHGFSDSDEVFPKEMTKWNSNDFIDAFASPMEAEGTPDPGTEGTKDLGDGARAPRDSEGPDGDSAGELGAETCEVHALFLVLHSGSILDSGPGDADSKRADVQTLSLAFEAVTRVHFPEALGHVALRLVPCPPICAAAYALVSNLSPYSHDGDSLSRSQDHIPLAALPLLATSSSRYQGAVATVIARTNQAYAAFLRSSEGAGFCGQVVLIGDGVGGILGFDALCHSASVGTGSRSSSRRGSMNNELLSPEAGPMRDPLAEGAEGLGRASPEPSALPTQRTPSDMAGPEPEGSQNSLQAAPPATSSGEPRRASTASCPPTATSEAPDSAPCAARLDFKVSGFFLFGSPLGLVLALRKTVMPTLEVAQMRPACEQIYNLFHAADPCASRLEPLLAPKFQAIAPLAVPRYQKFPLGDGSSLLLADTLQTHSGLFLEELEMLVPSTPTSASGAFWKGNELGGDPPAQPTAPSTTSEVVKILERWWGTKRIDYSLYCPEALTAFPTVTLPHLFHASYWESADVVAFILRQVIEKERPHLTECEEPSIYSPAFPREKWQRKRTQVKIRNVTSNHRASDTVVCEGRPQVLNGRFMYGPLDVVTLTGEKVDIYIMTQPLSGKWIHFGTEVTNSSGRLTFPVPLERALGVGVYPVRMVVRGDHTYAECCLTVVARGTEAVVFSIDGSFTASVSIMGSDPKVRAGAVDVVRHWQDAGYLIVYVTGRPDMQKHRVVAWLSQHNFPHGVVSFCDGLTHDPLRQKAMFLQSLVQEVELNFVAAYGSPKDVAVYAALGLPPSQTYIVGRAVRKLQAQCQFLSDGYVAHLGQLEAGSHPHATSGPSRAALAKSSYGGAAPVDFLRKQSQLLRSRGPSQAEREGPGTPPTTLARGKARSISLKLDSEE", "length": 1245, "header": "tr|E1B9I9-1|E1B9I9_BOVIN Isoform 1 of Phosphatidylinositol transfer protein membrane associated 1 OS=Bos taurus OX=9913 GN=PITPNM1 PE=3 SV=4 CANONICAL=E1B9I9-1" }, "locus": { "chromosome": "29", "start_pos": 45386038, "end_pos": 45373824, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013851.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013851.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013851.7", "url": "https://www.ensembl.org/id/ENSBTAP00000013851.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1483226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483226", "resource": "Reactome", "description": "Synthesis of PI" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 9, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1B9I9", "url": "https://www.uniprot.org/uniprotkb/E1B9I9" } ], "pmid": "" }, { "name": "phospholipid transporter activity", "id": "GO:0005548", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005548", "evidence": [ { "database": "UniProtKB", "id": "E1B9I9", "url": "https://www.uniprot.org/uniprotkb/E1B9I9" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "E1B9I9", "url": "https://www.uniprot.org/uniprotkb/E1B9I9" } ], "pmid": "" }, { "name": "receptor tyrosine kinase binding", "id": "GO:0030971", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030971", "evidence": [ { "database": "UniProtKB", "id": "E1B9I9", "url": "https://www.uniprot.org/uniprotkb/E1B9I9" } ], "pmid": "" }, { "name": "phosphatidylcholine binding", "id": "GO:0031210", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031210", "evidence": [ { "database": "UniProtKB", "id": "E1B9I9", "url": "https://www.uniprot.org/uniprotkb/E1B9I9" } ], "pmid": "" }, { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "E1B9I9", "url": "https://www.uniprot.org/uniprotkb/E1B9I9" } ], "pmid": "" }, { "name": "phosphatidic acid binding", "id": "GO:0070300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070300", "evidence": [ { "database": "UniProtKB", "id": "E1B9I9", "url": "https://www.uniprot.org/uniprotkb/E1B9I9" } ], "pmid": "" }, { "name": "phosphatidylinositol transfer activity", "id": "GO:0008526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008526", "evidence": [ { "database": "UniProtKB", "id": "E1B9I9", "url": "https://www.uniprot.org/uniprotkb/E1B9I9" } ], "pmid": "" }, { "name": "phosphatidylcholine transporter activity", "id": "GO:0008525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008525", "evidence": [ { "database": "UniProtKB", "id": "E1B9I9", "url": "https://www.uniprot.org/uniprotkb/E1B9I9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "E1B9I9", "url": "https://www.uniprot.org/uniprotkb/E1B9I9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B9I9", "url": "https://www.uniprot.org/uniprotkb/E1B9I9" } ], "pmid": "" }, { "name": "endoplasmic reticulum-plasma membrane contact site", "id": "GO:0140268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140268", "evidence": [ { "database": "UniProtKB", "id": "E1B9I9", "url": "https://www.uniprot.org/uniprotkb/E1B9I9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B9I9", "url": "https://www.uniprot.org/uniprotkb/E1B9I9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process", "id": "GO:1902633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902633", "evidence": [ { "database": "UniProtKB", "id": "E1B9I9", "url": "https://www.uniprot.org/uniprotkb/E1B9I9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 344, "end_pos": 346, "annotation": "n_glycosylation_sequon" }, { "start_pos": 496, "end_pos": 498, "annotation": "n_glycosylation_sequon" }, { "start_pos": 916, "end_pos": 918, "annotation": "n_glycosylation_sequon" }, { "start_pos": 977, "end_pos": 979, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BAF5-1", "uniprot_ac": "E1BAF5", "uniprot_id": "E1BAF5_BOVIN", "mass": { "chemical_mass": 25906.0, "monoisotopic_mass": 25906.0 }, "refseq": { "ac": "NP_001179998", "name": "brain-specific homeobox protein homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179998" }, "gene_names": [ { "name": "BSX", "type": "recommended", "evidence": [ { "id": "E1BAF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAF5" } ] }, { "name": "BSX", "type": "synonym", "evidence": [ { "id": "NP_001179998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179998" } ] } ], "protein_names": [ { "name": "Brain-specific homeobox protein homolog", "type": "recommended", "evidence": [ { "id": "E1BAF5", "database": "UniProtKB", "url": 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Is essential for normal postnatal growth and nursing. 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"https://www.ensembl.org/id/ENSBTAG00000013994" } ] } } ], "crossref": [ { "id": "E1BAF5", "url": "https://alphafold.ebi.ac.uk/entry/E1BAF5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013994", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013994", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615347", "url": "https://www.ncbi.nlm.nih.gov/gene/615347", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020479", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020479", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050848", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050848", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615347", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615347", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DLPGKHC", "url": "https://omabrowser.org/oma/group/DLPGKHC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAF5", "url": "https://www.orthodb.org/?gene=E1BAF5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24333", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24333", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24333:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24333:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179998", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SZL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZL0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAF5", "url": "https://www.uniprot.org/uniprotkb/E1BAF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAF5-1", "url": "https://www.uniprot.org/uniprotkb/E1BAF5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNLNFTSPLHPASSQRPTSFFIEDILLHKPKPLREVAPDHFTSTLASRVPLLDYGYPLMPTPTLLAPHPHHPLHKGDHHHPYFLTTSGVPVPALFPHPQHPELPGKHCRRRKARTVFSDSQLSGLEKRFEIQRYLSTPERVELATALSLSETQVKTWFQNRRMKHKKQLRKSQDEPKAPDGPESPEGSPRGPEAAPAEARLGLPAGSFVLTEPEDEVDIGDEAELGSGPHVL", "length": 232, "header": "tr|E1BAF5-1|E1BAF5_BOVIN Isoform 1 of Brain-specific homeobox protein homolog OS=Bos taurus OX=9913 GN=BSX PE=3 SV=1 CANONICAL=E1BAF5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZL0-1", "url": "https://www.uniprot.org/uniprotkb/E1BAF5/entry#A0AAA9SZL0-1", "sequence": { "sequence": "MNLNFTSPLHPASSQRPTSFFIEDILLHKPKPLREVAPDHFTSTLASRVPLLDYGYPLMPTPTLLAPHPHHPLHKGDHHHPYFLTTSGVPVPALFPHPQHPELPGKHCRRRKARTVFSDSQLSGLEKRFEIQRYLSTPERVELATALSLSETQMLFTCNLKTPGSTPSPLFSETQLAVKAQACQAPVIFLSDEKQQLCFSSLPVQGSCWTRYLDVTVRET", "length": 220, "header": "tr|A0AAA9SZL0-1|E1BAF5_BOVIN Computationally mapped isoform of Brain-specific homeobox protein homolog OS=Bos taurus OX=9913 GN=BSX PE=3 SV=1 CANONICAL=E1BAF5-1" }, "locus": { "chromosome": "15", "start_pos": 33602494, "end_pos": 33599387, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099875.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099875.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088821.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088821.1" } ] } }, { "isoform_ac": "E1BAF5-1", "url": "https://www.uniprot.org/uniprotkb/E1BAF5/entry#E1BAF5-1", "sequence": { "sequence": "MNLNFTSPLHPASSQRPTSFFIEDILLHKPKPLREVAPDHFTSTLASRVPLLDYGYPLMPTPTLLAPHPHHPLHKGDHHHPYFLTTSGVPVPALFPHPQHPELPGKHCRRRKARTVFSDSQLSGLEKRFEIQRYLSTPERVELATALSLSETQVKTWFQNRRMKHKKQLRKSQDEPKAPDGPESPEGSPRGPEAAPAEARLGLPAGSFVLTEPEDEVDIGDEAELGSGPHVL", "length": 232, "header": "tr|E1BAF5-1|E1BAF5_BOVIN Isoform 1 of Brain-specific homeobox protein homolog OS=Bos taurus OX=9913 GN=BSX PE=3 SV=1 CANONICAL=E1BAF5-1" }, "locus": { "chromosome": "15", "start_pos": 33602494, "end_pos": 33598814, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018597.4", "url": "https://www.ensembl.org/id/ENSBTAT00000018597.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018597.2", "url": "https://www.ensembl.org/id/ENSBTAP00000018597.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 61, "start_aa": "Thr", "end_pos": 61, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr61", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:615347", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615347", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A5F6-1", "protein_name": "Brain-specific homeobox protein homolog", "gene_name": "Bsx", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNLNFTSPLHPASSQRPTSFFIEDILLHKPKPLREVAPDHFASSLASRVPLLDYGYPLMPTPTLLTPHTHHPLHKGEHHHPYFLATSGMPVPALFPHPQHAELPGKHCRRRKARTVFSDSQLSGLEKRFEIQRYLSTPERVELATALSLSETQVKTWFQNRRMKHKKQLRKSQDEPKAADGPESPEGSPRAPEGAPADARLSLPAGAFVLTEPEDEVDIGDEGELSSGPHVL", "length": 232 }, "evidence": [ { "id": "E1BAF5", "url": "https://omabrowser.org/oma/group/E1BAF5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S9Q4-1", "protein_name": "Brain-specific homeobox protein homolog", "gene_name": "BSX", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNLNFTSPLHPASSQRPTSFFIEDILLHKPKPLREVAPDHFASSLASRVPLLDYGYPLMPTPTLLAPHPHHPLHKGDHHHPYFLTTSGVPVPALFPHPQHTELPGKHCRRRKARTVFSDSQLSGLEKRFEIQRYLSTPERVELATALSLSETQVKTWFQNRRMKHKKQLRKSQDEPKAPDGPESPEGSPRGAEAAPAEARLGLPAGPFVLTEPEDEVDIGDEGELGSGPHVL", "length": 232 }, "evidence": [ { "id": "E1BAF5", "url": "https://omabrowser.org/oma/group/E1BAF5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3C1V8-1", "protein_name": "Brain-specific homeobox protein homolog", "gene_name": "BSX", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNLNFTSPLHPASSQRPTSFFIEDILLHKPKPLREVAPDHFASSLASRVPLLDYGYPLMPTPTLLAPHAHHPLHKGDHHHPYFLTTSGMPVPALFPHPQHAELPGKHCRRRKARTVFSDSQLSGLEKRFEIQRYLSTPERVELATALSLSETQVKTWFQNRRMKHKKQLRKSQDEPKAPDGPESPEGSPRGSEAATAAEARLSLPAGPFVLTEPEDEVDIGDEGELGSGPHVL", "length": 233 }, "evidence": [ { "id": "E1BAF5", "url": "https://omabrowser.org/oma/group/E1BAF5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6R3Q6-1", "protein_name": "Brain-specific homeobox protein homolog", "gene_name": "bsx", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNLNYTSPVPQMPTQRSTSFFIEDILLHKPKPLREVFPSPFSNSIASRMPLLEYGYPLMPTPILAPHPHHPLHKPEHHPYFFTSGMQMPALFQHHPELPGKHCRRRKARTVFSDSQLSGLEKRFEIQRYLSTPERVELATALSLSETQVKTWFQNRRMKHKKQLRKTQDDQKTPNDVDRSLENTSESEMHEKNTDGKNGMSPDRYTLDDNEDDVDIEDDICSPEHLL", "length": 227 }, "evidence": [ { "id": "E1BAF5", "url": "https://omabrowser.org/oma/group/E1BAF5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6RFL5-1", "protein_name": "Brain-specific homeobox protein homolog", "gene_name": "BSX", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNLNFTSPVHPVPAPRPTSFFIEDILLHKPKPLREVPPEHFAGSLASRVPLLDYGYPLMPAPALLAPHPHPALHKPEHHHHHPYFLTTSGVPVPALFPHHAHAELPGKHCRRRKARTVFSDSQLSGLEKRFEIQRYLSTPERVELATALSLSETQVKTWFQNRRMKHKKQLRKSQDDPIHEENREQSSPEPELPEPAAAEPRKGPPGPFLLQDPEDEVDILEEGDILAAPHRL", "length": 233 }, "evidence": [ { "id": "E1BAF5", "url": "https://omabrowser.org/oma/group/E1BAF5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q810B3-1", "protein_name": "Brain-specific homeobox protein homolog", "gene_name": "Bsx", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNLNFTSPLHPASSQRPTSFFIEDILLHKPKPLREVAPDHFASSLASRVPLLDYGYPLMPTPTLLTPHAHHPLHKGDHHHPYFLTTSGMPVPALFPHPQHAELPGKHCRRRKARTVFSDSQLSGLEKRFEIQRYLSTPERVELATALSLSETQVKTWFQNRRMKHKKQLRKSQDEPKAADGPESPEGSPRAPEGAPADARLSLPAGAFVLTEPEDEVDIGDEGELSSGPHVL", "length": 232 }, "evidence": [ { "id": "E1BAF5", "url": "https://omabrowser.org/oma/group/E1BAF5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BAF5", "url": "https://www.uniprot.org/uniprotkb/E1BAF5" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BAF5", "url": "https://www.uniprot.org/uniprotkb/E1BAF5" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BAF5", "url": "https://www.uniprot.org/uniprotkb/E1BAF5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BAF5", "url": "https://www.uniprot.org/uniprotkb/E1BAF5" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "E1BAF5", "url": "https://www.uniprot.org/uniprotkb/E1BAF5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BAF5", "url": "https://www.uniprot.org/uniprotkb/E1BAF5" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BAF5", "url": "https://www.uniprot.org/uniprotkb/E1BAF5" } ], 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"Protein" ] }, { "id": "E1B704-1", "url": "https://www.uniprot.org/uniprotkb/E1B704-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDGEGGGPLRACAVAACVGSCGGSHGSVPSRGAGRRAGEARRGEARASRARGTMSDAGGGKKPPVEPQAGPGPGPGRAAGERGLPGSFPLVLKKLMENPPRETRLDKEKGKEKLEEDEAAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLVQNLLLPVAELEGKESASSSTASPPSSTAVFQPSETVSSTESSLEKERETPSPIDPNCVEVDVNFNPDPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL", "length": 355, "header": "tr|E1B704-1|E1B704_BOVIN Isoform 1 of TEF transcription factor, PAR bZIP family member OS=Bos taurus OX=9913 GN=TEF PE=3 SV=3 CANONICAL=E1B704-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T1C2-1", "url": "https://www.uniprot.org/uniprotkb/E1B704/entry#A0AAA9T1C2-1", "sequence": { "sequence": 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"evidence": [ { "id": "E1B704", "url": "https://omabrowser.org/oma/group/E1B704/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9JLC6-1", "protein_name": "Thyrotroph embryonic factor", "gene_name": "Tef", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDAGGGKKPPVEPQAGPGPGRAAGERGLSGSFPLVLKKLMENPPRETRLDKEKGKEKLEEDESAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAQNLLLPVAELEGKESASSSTASPPSSSTAIFQPSETVSSTESSLEKERETPSPIDPSCVEVDVNFNPDPADLVLSSVPGGELFNPRKHRFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL", "length": 301 }, "evidence": [ { "id": "E1B704", "url": "https://omabrowser.org/oma/group/E1B704/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": 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"https://www.uniprot.org/uniprotkb/E1B704" }, { "id": "PS50217", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50217" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BZIP", "eco_id": "ECO_0000259", "start_pos": 285, "end_pos": 348, "start_aa": "Asp", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B768-1", "uniprot_ac": "E1B768", "uniprot_id": "E1B768_BOVIN", "mass": { "chemical_mass": 101941.0, "monoisotopic_mass": 101941.0 }, "refseq": { "ac": "NP_001422072", "name": "leucine--tRNA ligase, mitochondrial isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422072" }, "gene_names": [ { "name": "LARS2", "type": "recommended", "evidence": [ { "id": "E1B768", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B768" } ] }, { "name": "LARS2", "type": "synonym", "evidence": [ { "id": "NP_001422072", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422072" } ] } ], "protein_names": [ { "name": "leucine--tRNA ligase", "type": "recommended", "evidence": [ { "id": "E1B768", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B768/entry#names_and_taxonomy" } ] }, { "name": "6.1.1.4", "type": "synonym", "evidence": [ { "id": "E1B768", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B768/entry#names_and_taxonomy" } ] }, { "name": "Leucyl-tRNA synthetase", "type": "synonym", "evidence": [ { "id": "E1B768", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B768/entry#names_and_taxonomy" } ] }, { "name": "leucine--tRNA ligase, mitochondrial isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001422072", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422072" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B768", "url": "https://www.uniprot.org/uniprotkb/E1B768" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LARS2", "url": "https://www.uniprot.org/uniprotkb/E1B768", "locus": { "chromosome": "22", "start_pos": 53739967, "end_pos": 53886711, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007315", "url": "https://www.ensembl.org/id/ENSBTAG00000007315" } ] } } ], "crossref": [ { "id": "E1B768", "url": "https://alphafold.ebi.ac.uk/entry/E1B768", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007315", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007315", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00812", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00812", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07958", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07958", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504609", "url": "https://www.ncbi.nlm.nih.gov/gene/504609", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002300", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002300", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002302", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002302", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009080", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009080", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013155", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013155", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025709", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GIEHACM", "url": "https://omabrowser.org/oma/group/GIEHACM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B768", "url": "https://www.orthodb.org/?gene=E1B768", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43740", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43740", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43740:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43740:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00133", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00133", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08264", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08264", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13603", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13603", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001422072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422072", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11688", "url": "https://www.rhea-db.org/rhea/11688", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T1E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1E2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1E2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1E2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B768", "url": "https://www.uniprot.org/uniprotkb/E1B768", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B768-1", "url": "https://www.uniprot.org/uniprotkb/E1B768-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGP9", "url": "https://www.uniprot.org/uniprotkb/F1MGP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGP9-1", "url": "https://www.uniprot.org/uniprotkb/F1MGP9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPSWQRLGLYACLLKRQLNDGPDVIKWGRRVIPGWSRGIYSATGEWTKEYTLQTRKDVEKWWHQRIKDQALTVSEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTQSNIRHMRKQLDQLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALAGLPEWYGIKGMQAHWIGNCVGCHLDFMLKVDGQVTGEKLSAYTATPEAVYGASHVAISPSHRLLHGHSPLKETFRKALVPGQDCLTPVTAVNMLTQQEVPVIILAKDDLEGSLDAKIGIPSTSLEDSALAQTLGLSYSEVIEETPDGTERLRGSAEFTGMKRQDAFLALTQKARRERVGGDVTSDKLKDWLVSRQRYWGTPIPMVHCPACGPVPVPLEDLPVTLPSITPLTGRGGSPLASASEWVNCSCPRCKGAATRETDTMDTFVDSAWYYFRYTDPQNTQSPFSAALADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQYLRREEVDLTGSDPVHANTGEKLEVSWEKMSKSKHNGVEPEDVVEQYGRDTVRLYVLFAAPPEKDILWDVKTDALPGVLRWQQRLWALVTRFIEARTSGKAPRPQLLSDKDKAEARRLWEYKNSVISQVTAHFTEDFSLNSAISQLMGLSSALSQASQRVVLHSPEFEDALCALMVMAAPMAPHITSELWAGLALVPQKLCAHYAWNTSVLLQAWPTVDPQFLQQPEVVQMAVLINNKACGKVPVPQHVAQDQDKVHELVLQSELGVRLLQGRSIKKAFLSPRTALINFLLQE", "length": 903, "header": "tr|E1B768-1|E1B768_BOVIN Isoform 1 of leucine--tRNA ligase OS=Bos taurus OX=9913 GN=LARS2 PE=3 SV=3 CANONICAL=E1B768-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T1E2-1", "url": "https://www.uniprot.org/uniprotkb/E1B768/entry#A0AAA9T1E2-1", "sequence": { "sequence": "MAPSWQRLGLYACLLKRQLNDGPDVIKWGRRVIPGWSRGIYSATGEWTKEYTLQTRKDVEKWWHQRIKDQALTVSEADVINPMGWDAFGLPAENAAIERNLHPESWTQSNIRHMRKQLDQLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALAGLPEWYGIKGMQAHWIGNCVGCHLDFMLKVDGQVTGEKLSAYTATPEAVYGASHVAISPSHRLLHGHSPLKETFRKALVPGQDCLTPVTAVNMLTQQEVPVIILAKDDLEGSLDAKIGIPSTSLEDSALAQTLGLSYSEVIEETPDGTERLRGSAEFTGMKRQDAFLALTQKARRERVGGDVTSDKLKDWLVSRQRYWGTPIPMVHCPACGPVPVPLEDLPVTLPSITPLTGRGGSPLASASEWVNCSCPRCKGAATRETDTMDTFVDSAWYYFRYTDPQNTQSPFSAALADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQYLRREEVDLTGSDPVHANTGEKLEVSWEKMSKSKHNGVEPEDVVEQYGRDTVRLYVLFAAPPEKDILWDVKTDALPGVLRWQQRLWALVTRFIEARTSGKAPRPQLLSDKDKAEARRLWEYKNSVISQVTAHFTEDFSLNSAISQLMGLSSALSQASQRVVLHSPEFEDALCALMVMAAPMAPHITSELWAGLALVPQKLCAHYAWNTSVLLQAWPTVDPQFLQQPEVVQMAVLINNKACGKVPVPQHVAQDQDKVHELVLQSELGVRLLQGRSIKKAFLSPRTALINFLLQE", "length": 860, "header": "tr|A0AAA9T1E2-1|E1B768_BOVIN Computationally mapped isoform of leucine--tRNA ligase OS=Bos taurus OX=9913 GN=LARS2 PE=3 SV=1 CANONICAL=E1B768-1" }, "locus": { "chromosome": "22", "start_pos": 53882367, "end_pos": 53741300, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121857.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121857.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090400.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090400.1" } ] } }, { "isoform_ac": "E1B768-1", "url": "https://www.uniprot.org/uniprotkb/E1B768/entry#E1B768-1", "sequence": { "sequence": "MAPSWQRLGLYACLLKRQLNDGPDVIKWGRRVIPGWSRGIYSATGEWTKEYTLQTRKDVEKWWHQRIKDQALTVSEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTQSNIRHMRKQLDQLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALAGLPEWYGIKGMQAHWIGNCVGCHLDFMLKVDGQVTGEKLSAYTATPEAVYGASHVAISPSHRLLHGHSPLKETFRKALVPGQDCLTPVTAVNMLTQQEVPVIILAKDDLEGSLDAKIGIPSTSLEDSALAQTLGLSYSEVIEETPDGTERLRGSAEFTGMKRQDAFLALTQKARRERVGGDVTSDKLKDWLVSRQRYWGTPIPMVHCPACGPVPVPLEDLPVTLPSITPLTGRGGSPLASASEWVNCSCPRCKGAATRETDTMDTFVDSAWYYFRYTDPQNTQSPFSAALADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQYLRREEVDLTGSDPVHANTGEKLEVSWEKMSKSKHNGVEPEDVVEQYGRDTVRLYVLFAAPPEKDILWDVKTDALPGVLRWQQRLWALVTRFIEARTSGKAPRPQLLSDKDKAEARRLWEYKNSVISQVTAHFTEDFSLNSAISQLMGLSSALSQASQRVVLHSPEFEDALCALMVMAAPMAPHITSELWAGLALVPQKLCAHYAWNTSVLLQAWPTVDPQFLQQPEVVQMAVLINNKACGKVPVPQHVAQDQDKVHELVLQSELGVRLLQGRSIKKAFLSPRTALINFLLQE", "length": 903, "header": "tr|E1B768-1|E1B768_BOVIN Isoform 1 of leucine--tRNA ligase OS=Bos taurus OX=9913 GN=LARS2 PE=3 SV=3 CANONICAL=E1B768-1" }, "locus": { "chromosome": "22", "start_pos": 53882367, "end_pos": 53741300, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054819.4", "url": "https://www.ensembl.org/id/ENSBTAT00000054819.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052354.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052354.3" } ] } }, { "isoform_ac": "F1MGP9-1", "url": "https://www.uniprot.org/uniprotkb/E1B768/entry#F1MGP9-1", "sequence": { "sequence": "MAPSWQRLGLYACLLKRQLNDGPDVIKWGRRVIPGWSRGIYSATGEWTKEYTLQTRKDVEKWWHQRIKDQALTVSEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTQSNIRHMRKQLDQLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALAGLPEWYGIKGMQAHWIGNCVGCHLDFMLKVDGQVTGEKLSAYTATPEAVYGASHVAISPSHRLLHGHSPLKETFRKALVPGQDCLTPVTAVNMLTQQEVPVIILAKDDLEGSLDAKIGIPSTSLEDSALAQTLGLSYSEVIEETPDGTERLRGSAEFTGMKRQDAFLALTQKARRERVGGDVTSDKLKDWLVSRQRYWGTPIPMVHCPACGPVPVPLEDLPVTLPSITPLTGRGGSPLASASEWVNCSCPRCKGAATRETDTMDTFVDSAWYYFRYTDPQNTQSPFSAALADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQYLRREEVDLTGSDPVHANTGEKLEVSWEKMSKSKHNGVEPEDVVEQYGRDTVRLYVLFAAPPEKDILWDVKTDALPGVLRWQQRLWALVTRFIEARTSGKAPRPQLLSDKDKAEARRLWEYKNSVISQVTAHFTEDFSLNSAISQLMGLSSALSQASQRVVLHSPEFEDALCALMVMAAPMAPHITSELWADQQQSLRQSPRAPARRPGPGQSPRTGSPERAGSQALTGAKHQEGLPLSAHRPHQLPAAGVTAGRCGPSSRSGAPARGKAQCLERLPPQGASAV", "length": 894, "header": "tr|F1MGP9-1|E1B768_BOVIN Computationally mapped isoform of leucine--tRNA ligase OS=Bos taurus OX=9913 GN=LARS2 PE=3 SV=3 CANONICAL=E1B768-1" }, "locus": { "chromosome": "22", "start_pos": 53882367, "end_pos": 53741199, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053558.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053558.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050604.3", "url": "https://www.ensembl.org/id/ENSBTAP00000050604.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2R8T0-1", "protein_name": "leucine--tRNA ligase", "gene_name": "LARS2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAPWQRLRFYAFLLQRQLNGGPDVINWGRGVIPGCSRGIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTQSNIRHMRKQLDRLGLCFSWDREITTCLPDYYRWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDTLADLPEWYGIKGMQAHWIGDCVGCHLDFALKVDGQVTEEELSAYTATPEAIYGTSHVAISPSHRLLHGCSSLKEVFQKALVPGRDCLTPVMAVNMLTQQEVPVIILAKADFEGSLDAKIGIPSTSSEDTVLAQSLGLSYSEVIETSPDGTERLSNSAEFTGMNRLDAFLALTQKARRKRVGGDVTSDKLKDWLISRQRYWGTPIPMVHCPACGPVPVPLDDLPVTLPSITSFTGKGGSPLASASEWVNCSCPRCKGAATRETDTMDTFVDSAWYYFRYTDPQNTQSPFSTALADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQYLQREEVDLTGSVPVHVKTREKLEVTWEKMSKSKHNGVDPEDVVEQYGIDTIRLYLLFAAPPEKDILWDVKTDALPGVLRWQQRLWALATRFIEARISEKVPRPQLLSNKEKAEAKKLWEYKNSVISQVTAHFTEDLSLNSVISHLMGLSSALSQASQRVVLHSPEFEDALCALMVMAAPMAPHITSELWAGLALVPRKLCPHYAWDADVLLQAWPAVDPQFLQQPDVVQMAVLINNKACGKIPVPQQVAQDQDKVYELVLQSELGIKLLQGRSIKKAFLSPRTALINFLVQE", "length": 902 }, "evidence": [ { "id": "E1B768", "url": "https://omabrowser.org/oma/group/E1B768/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I5ZU78-1", "protein_name": "leucine--tRNA ligase", "gene_name": "Lars2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASACQRLSFCVSPLKRQLVSGLPVILWERIIPGCSRSIYSATGKWTKEYTLQTRKDVEKWWHQQIKVQASKISEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVNEYGCSWRSGAKVEKKYLRQWFIKTTAYAKAMQDALADLPEWYGIKEMQAHWIGDCVGCHLDFTLKVDGQDTGEKLTAYTATPEAIYGISHVAISPSHGLLHGCSSLKTALQKALVPGRDCLTPVMAVNMLTLQEVPVVIMAKPDLEGSLDSKIGIPSTSSEDTRLAQALGLPYSEVIETSPDGTERLSGSAEFTGMTRQDAFVALTRKARGMRVGGHVTSNKLKDWLVSRQRYWGTPIPIVHCPACGPVPVPLQDLPVTLPSITSLTGRGGSPLASALEWVNCSCPRCKGSAKRETDTMDTFVDSAWYYFRYTDPHNTHSPFSSALADFWMPVDLYIGGKEHAVMHLFYARFFSHFCHRQKMVKHREPFHKLLAQGLIKGQTFHLLSGQCLKREDIDFTGPTPVCAKTKERLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWSLTTRFIEARTSGTAPQPQLLNNKEKAKARSLWEYKNAVITQVTTHFTEDFALNSVVSQLMGLSGALSQASQRLVLHSPEFEDALCALLVMAAPLAPHITSELWAGLALVPSKLCDRYAWDAGVMLQAWPTVDSQFLQKPDMVQMAVLINNKACGKIPVPQHVAQDQDKVHEFVLQSELGIKLLQGRSIRKAFLSPRTALINFLVKE", "length": 902 }, "evidence": [ { "id": "E1B768", "url": "https://omabrowser.org/oma/group/E1B768/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0YV38-1", "protein_name": "leucine--tRNA ligase", "gene_name": "LARS2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDTVALRMQSVCRRFGACSTCLNRQLNGFLGLRNRTPLPSHACIRTIYSETGRWEKNYGQETRRRVENWWFPRIKEQFCRISETDKSRPKFYVLSMFPYPSGKLHMGHVRVYTISDTVARFQKMRGMQVLNPMGWDAFGLPAENAAIEHGLHPASWTQSNIQHMREQFDALGLSFTWEREITTCLPEYYKWTQYLFLKLFESGMVYQKEALVNWDPVDQTVLANEQVDDNGCSWRSGAKVEQKYLKQWFIKTTAYAKAMFDALSDLPEWYGIKEMQANWIGDCVGCSLDFLLKVNGEVTGEKLAAYTYTPEAIYGASHLYILPSHRLLHGNSSLKEVFQREFIPGKDSLTSVTAVNLLTNQEIPVVISGKTSFENYLDTKIGIPCTSAEDAAVAKNLNISFTEVIEKLPNGLEKVINSGEFTGMTRQDALKALTQQAKNKGIGGDLMSDKLRDWLISRQRYWGTPIPVIHCRTCGTVPVPYEDLPVVLPNVTTFTGKGASPLETVPEWVNCACPRCKAEARREIDTMDTFVDSAWYYLRYTDPHNTQRPFNRDLADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDLKMTKHKEPFHKLLVQGLIKNQTFRLRTTGQYLKREEIDLTGTEPVHLKSGEKVQVTWEKMSKSKHNGIDPEELMKEYGIDTIRLYILFAAPPEQDILWDTKTDAMPGVQRWQTRLWTLVTKLIEARTSETMPNPEVLSKKQKAEARRIWEQKNLVISEVTEYFTKDHLFNAAISRLMSLSNVLHQASWPLVLHSAEYEDALATLCVMVAPMAPHIASEMWKGLAHIENKLCTHHNWGADVLHQSWPKVDPEYLQPPDVVEMSVLINNKACGKVFVPQQAARNFAEVHELVLQSELGAKHLQGRTIKKAFLSPRTALINFLVQERKR", "length": 914 }, "evidence": [ { "id": "E1B768", "url": "https://omabrowser.org/oma/group/E1B768/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HWS5-1", "protein_name": "leucine--tRNA ligase", "gene_name": "Lars2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASACQRLRFYACPLTRQLVCGPPVIQWERRTIPACARSIYSATGTWTKEYTLQTRKDVENWWHRQIKEQASRISEDDKSKPKFYVLSMFPYPSGKLHMGHIRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTQSNIKYMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVNEYGCSWRSGAKVEKKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLEFTLKVDGQDTGEKLTAYTATPEAIYGISHVAISPNHRLLHGCSSLKEPLQKVLVPGRDCLTPVMAVNMLTQQEVPIVVMAKADLEGSLDSKIGIPSTSSEDTSIAQALGLPYSEVIETSPDGTERLSGSAEFTGMTRQDAFLALTQKARGMRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPACGPVPVPLQDLPVTLPSITSFTGKGGSPLASALEWVNCPCPRCKRPARRETDTMDTFVDSAWYYLRYTDPQNTHRPFSPALANFWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGLCLKREDIDFTGPAPVCARTKEKLEVTWEKMSKSKHNGVDPEEIVAQYGIDTVRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWSLTTRFIEARTRGSAPQPQLLNNKEETKARNLWEYKNSVITQVTTHFTEDFALNSAVSQLMGLSSALLQASDRVVLHSREFEDALCALLVMAAPMAPHITSELWAGLALVPSKLCDHYAWDAGVMLQAWPTVDSEFLQQPDVVQMAILINNKAYGKISVPQQVAQDQDKVHEFVLQSELGTRLLQGRSIKKAFLSPRTALINFLVQE", "length": 903 }, "evidence": [ { "id": "E1B768", "url": "https://omabrowser.org/oma/group/E1B768/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q15031-1", "protein_name": "Leucine--tRNA ligase, mitochondrial", "gene_name": "LARS2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYTATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVILAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPHSPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGIDTIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNKEKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDALCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQMAVLINNKACGKIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFLVQD", "length": 903 }, "evidence": [ { "id": "E1B768", "url": "https://omabrowser.org/oma/group/E1B768/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54ET5-1", "protein_name": "Leucine--tRNA ligase, mitochondrial", "gene_name": "mleuS", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFNLYRSSLKNLKLPNINNNIKSNLVIRSYTTNINGNIKNDDDNNKFYSLSQFPYPSGALHMGHVRVYTISDCIARLKRMQGYDVIHPMGWDAFGLPAENAAIDKQVSPSEWTNLNISSMRDQLKLLNFQFDWDRELSTCNKEYYRWTQEIFLRLLKSGLAYRKSATVNWDPIDQTVLANEQVDAQGRSWRSNAIVEKKEMKQWFYKITSMADRLTDDLDQLPGWSDEIKNMQKEWIGRSYGHLIEFQSCAQKPLSNITVFTTRAETIYGVSFLAISPHHSEINQIRANLINDEKRLELDQYLKEIQEIKNKMGTQEDVENLKTFNTGLTFYQPITKKYIPLILSNFVHADYGTGAVMGVPSHNRSDYQVAKQQNLKLLPVLGIEREQQQQQQQQQQQQQLEIEEECYDYSNTGKLINSGQDTGIEFKEFIKRLEDQQLIKRQTNYRIHDWLISRQRYWGTPIPIIVCEKCGDVPVPSDQLPVELPIDIQFTGKGNLLNQLDHWKNVKCPCCGSQATRETDTMDTFVDSSWYFLRFLDSKNSQSIFSSELVNRFMPIDVYVGGIEHAILHLLYSRFITKFLKDQQLIDHSEPFKVLLAQGLVKSPTYRDSITNKPIHPSNVEFKTIKSNESGKSQQQTINKLTGNQVSVTIEKMSKSKLNGIDPKEIIDKYGSDTLKTYILFKAPPEKSLDWDTQGIEGCKKWLTRINVSIQSFLNQFDVIEGKEQHQHQQQQHQQPLPSSEFNEQQSKEVKDILFETHLTMNKVTESIDKHSFNTGIAALMELSNTLQKSSPQIKLTKEYYQSLRALTLMLFPFSPIFSQIHWKSLIDDLPQSCKSFYSENYSSFEQQSYGNSNDNDVFNQRWPKPTPSALVRDFNSLVIQFDGKTKGVESIPTSITDFSNFVQSNSKYLNRFKDKTIDQIFIGTTKTGNSINFTFKKK", "length": 940 }, "evidence": [ { "id": "E1B768", "url": "https://omabrowser.org/oma/group/E1B768/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8VDC0-1", "protein_name": "Probable leucine--tRNA ligase, mitochondrial", "gene_name": "Lars2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASTCQRLSFYVSPLKRQLVSRPPVILWERLIPGCSRSIYSATGKWTKEYTLQTRKDVEKWWHQQIKEQASRVSEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVNEYGCSWRSGAKVEKKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVDGEDTGEKLTAYTATPEAIYGISHVAISPSHGLLHGCSSVKKALQKALVPGRDCLTPVMAVSMLTLQEVPIVIMANPDLEGSLDSKIGIPSTSSEDTRLAQALGLPYSEVIEASPDGTERLSGSAEFTGMTRQDAFVALTRKARGMRVGGHVTSNKLKDWLISRQRYWGTPIPIVHCPACGPVPVPLQDLPVILPSIASLTGRGGSPLATALEWVNCSCPRCKGSAKRETDTMDTFVDSAWYYFRYTDPHNTQSPFGSALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQCLKKEDIDFTGPAPVCAKTKEKLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWSLTTRFIEARTSGTVPQPQLLNSKEKTKAQNLWEYKNAVIAQVTTHFTEDFALNSVVSQLMGLSSALSQASQRVVLHSPEFEDALCALLVMAAPLAPHVTSELWAGLTLVPSKLCDHYAWDSGVMLQAWPTVDSQFLQKPDMVQMAVLINNKACGKIPVPQHVAQDQDKVHELVLQSELGMKLLQGRSIKKAFLSPRTALINFLVQE", "length": 902 }, "evidence": [ { "id": "E1B768", "url": "https://omabrowser.org/oma/group/E1B768/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VZ82-1", "protein_name": "leucine--tRNA ligase", "gene_name": "LeuRS-m", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MQALRRTRPWGAVYWNSWRRLLTQSCTRNDNPELTSDVKHRIEAHWREQLSGGQFNPKDSQDKYYVLSMFPYPSGNLHMGHVRVYTIADSVARFQRMCGKNVFQPMGWDSFGLPAENAANQRGVEPASWTEQNIAQMKEQLKRLGCSFDWNHELSTCSPKYYKWTQHLFLMLHRHGLAYQNEALVNWDPVDKTVLADEQVDANGCSWRSGAKVEKKLLRQWFIRTSAYAKQLLDGLEDPTLRDWRDIINLQRHWIGECDGYAFNLLTSASGLLRVWTTHPEHLKDPHAFLVLRSNHHLSKLKGADSLSAANPFAGTTMPVVFSDEVTFPPKSDVYLAAPSFRGEDKDLWDSYGLAFTSNGKDEESLSPANWEMLRKEVLQAATRLNVGGYRVSSKLKDWLISRQRYWGTPIPIVHCQKCGAVPVPEEQLPVSLPPKDSPKEAFLCDCPKCGEKDARRETDTMDTFVDSSWYYLRYLDAQNSERIFDTALTKKFMPVDLYIGGKEHAVLHLYYARFINHFLHSCGLSPTSEPFSRLLVQGMVMGRSFRVKGSGRYVPETEVEIVNAKKNQAVLKETKEPVVMTWEKMSKSKLNGVEPSDMFNEYGTDTTRLIILADVAPTSHRNWSSATFPGILNWQKRLWLTLQDFQQAREDQTASDVVPTSEEFLAEDAKLFDARNFYVKGATFNYRHAQQLSVAISKMQGLTNSLRRTPKHVLRHGKQFERALAAQIIMLAPMAPHFASELWSKFVAIPGRLNPASQELQWSEDVLAQRWPDIDPAYNLDLSIKVNGFENCVIKVQRTHLDKVTHSDALDIAFNTESVTSYLIDKKIRTTNFVLYPGIEAILNIYVDKAKMKQKPPTTDDAEAQPQA", "length": 869 }, "evidence": [ { "id": "E1B768", "url": "https://omabrowser.org/oma/group/E1B768/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9XEA0-1", "protein_name": "Leucine--tRNA ligase, chloroplastic/mitochondrial", "gene_name": "EMB2369", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSSHHQILQIRSDPFVLSHCCRHTRLTSSLTLQSPLKQPFSCLPFRWRRSYRGGVRSSTTETHGSKKEALVSETATTSIELKRVYPFHEIEPKWQRYWEDNRIFRTPDDVDTSKPKFYVLDMFPYPSGAGLHVGHPLGYTATDILARLRRMQGYNVLHPMGWDAFGLPAEQYAIETGTHPKTTTLKNIDRFRLQLKSLGFSYDWDRELSTTEPDYYKWTQWIFLQLYKKGLAYQAEVPVNWCPALGTVLANEEVVDGVSERGGHPVIRKPMRQWMLKITAYADRLLEDLDELEWPESIKEMQRNWIGRSEGAELNFSILDGEGRETDKEITVYTTRPDTLFGATYMVVAPEHQLLSYFVTAEQKQQVEEYKDFASRKSDLERTELQKDKTGVFTGCYAKNPANGDAIPIWVADYVLASYGTGAIMAVPAHDTRDNEFALKYNIPIKWVVRNEANSSDDAKQVYPGLGIIENSSTLETGLDINQLSSKEAALKVIEWAERTGNGKKKVNYKLRDWLFARQRYWGEPIPILILDESGETIAISESELPLTLPELNDFTPTGTGEPPLSKAVSWVNTVDPSTGKPAKRETSTMPQWAGSCWYYLRFMDPKNPEALVDKEKEKYWSPVDVYVGGAEHAVLHLLYSRFWHKVLYDIGVVSTKEPFKCVINQGIILGEVQYTAWKDQEGNYVSADTEERLNEHQQVTIPEEKVIKSGDHFVLKEDPSIRLIPRVYKMSKSRGNVVNPDDVVLEYGADSLRLYEMFMGPFRDSKTWNTSGIEGVHRFLARTWRLVIGLPQSDGSFKDGTLVTDDEPTLEQLRTLHKCIAKVTEEIESTRFNTGISGMMEFVNAAYKWNNQPRGIIEPFVLLLSPYAPHMAEELWSRLGHPNSLAYESFPKANPDYLKNTTIVLPVQINGKTRGTIEVEEGCSEDDAFVLASQDDKLRKYLDGQSIKKRIYVPGKILNVILDRTNVKVTTK", "length": 973 }, "evidence": [ { "id": "E1B768", "url": "https://omabrowser.org/oma/group/E1B768/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "aminoacyl-tRNA deacylase activity", "id": "GO:0002161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002161", "evidence": [ { "database": "UniProtKB", "id": "E1B768", "url": "https://www.uniprot.org/uniprotkb/E1B768" } ], "pmid": "" }, { "name": "leucine-tRNA ligase activity", "id": "GO:0004823", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004823", "evidence": [ { "database": "UniProtKB", "id": "E1B768", "url": "https://www.uniprot.org/uniprotkb/E1B768" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1B768", "url": "https://www.uniprot.org/uniprotkb/E1B768" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "leucyl-tRNA aminoacylation", "id": "GO:0006429", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006429", "evidence": [ { "database": "UniProtKB", "id": "E1B768", "url": "https://www.uniprot.org/uniprotkb/E1B768" } ], "pmid": "" }, { "name": "mitochondrial translation", "id": "GO:0032543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032543", "evidence": [ { "database": "UniProtKB", "id": "E1B768", "url": "https://www.uniprot.org/uniprotkb/E1B768" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1B768", "url": "https://www.uniprot.org/uniprotkb/E1B768" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "E1B768", "url": "https://www.uniprot.org/uniprotkb/E1B768" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 503, "end_pos": 505, "annotation": "n_glycosylation_sequon" }, { "start_pos": 817, "end_pos": 819, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11688", "name": "", "equation": "tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1B768-1", "A0A3S5ZPT9-1" ], "evidence": [ { "id": "11688", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11688" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3S5ZPT9", "gene_name": "LARS1", "activity": [ { "ec_number": "6.1.1.4", "activity": "tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate.", "evidence": [ { "id": "A0A3S5ZPT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPT9" } ] }, { "ec_number": "6.1.1.4", "activity": "", "evidence": [ { "id": "A0A3S5ZPT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPT9" } ] } ] }, { "uniprot_ac": "E1B768", "gene_name": "LARS2", "activity": [ { "ec_number": "6.1.1.4", "activity": "tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate.", "evidence": [ { "id": "E1B768", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B768" } ] }, { "ec_number": "6.1.1.4", "activity": "", "evidence": [ { "id": "E1B768", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B768" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B768-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 903, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B768-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B768" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B768", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B768" }, { "id": "PF00133", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00133" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Aminoacyl-tRNA synthetase class Ia", "eco_id": "ECO_0000259", "start_pos": 71, "end_pos": 257, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B768", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B768" }, { "id": "PF13603", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13603" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Leucyl-tRNA synthetase editing", "eco_id": "ECO_0000259", "start_pos": 271, "end_pos": 324, "start_aa": "His", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B768", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B768" }, { "id": "PF08264", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08264" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding", "eco_id": "ECO_0000259", "start_pos": 729, "end_pos": 848, "start_aa": "Trp", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.1.1.4", "ec_name": "tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate.", "evidence": [ { "id": "6.1.1.4", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.4" }, { "id": "6.1.1.4", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.1.1.4" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 503, "end_pos": 505 }, { "start_pos": 817, "end_pos": 819 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCZ9-1", "uniprot_ac": "E1BCZ9", "uniprot_id": "E1BCZ9_BOVIN", "mass": { "chemical_mass": 123440.0, "monoisotopic_mass": 123440.0 }, "refseq": { "ac": "NP_001192960", "name": "activity-dependent neuroprotector homeobox protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192960" }, "gene_names": [ { "name": "ADNP", "type": "recommended", "evidence": [ { "id": "E1BCZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9" } ] }, { "name": "ADNP", "type": "synonym", "evidence": [ { "id": "NP_001192960", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192960" } ] } ], "protein_names": [ { "name": "Activity-dependent neuroprotector homeobox protein", "type": "recommended", "evidence": [ { "id": "E1BCZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9/entry#names_and_taxonomy" } ] }, { "name": "Activity-dependent neuroprotective protein", "type": "synonym", "evidence": [ { "id": "E1BCZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9/entry#names_and_taxonomy" } ] }, { "name": "activity-dependent neuroprotector homeobox protein", "type": "synonym", "evidence": [ { "id": "NP_001192960", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192960" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation.", "evidence": [ { "database": "UniProtKB", "id": "E1BCZ9", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9#function" }, { "database": "UniProtKB", "id": "ARBA00055046", "url": "https://www.uniprot.org/uniprotkb/ARBA00055046#function" }, { "database": "UniProtKB", "id": "A0AAA9T1U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1U8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCZ9", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ADNP", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9", "locus": { "chromosome": "13", "start_pos": 78817785, "end_pos": 78828378, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000340", "url": "https://www.ensembl.org/id/ENSBTAG00000000340" } ] } } ], "crossref": [ { "id": "E1BCZ9", "url": "https://alphafold.ebi.ac.uk/entry/E1BCZ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000340", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000340", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533757", "url": "https://www.ncbi.nlm.nih.gov/gene/533757", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038861", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038861", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045762", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045762", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533757", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533757", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PYCTFNG", "url": "https://omabrowser.org/oma/group/PYCTFNG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCZ9", "url": "https://www.orthodb.org/?gene=E1BCZ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15740", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15740", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15740:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15740:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19627", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19627", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26748", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26748", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9940465", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9940465", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192960", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192960", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T1U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1U8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1U8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1U8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCZ9", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCZ9-1", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACPFSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTFNADKKTLETHIKIFHAPNASAPSSSLSTFKDKSKSDGLKPKQADSVEQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKAGEKSLNGAVPLGTNAREESSIHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLIAPKPQEKKGMGLQSRIGSLASGNVRSLPSQQMVNRLSIPKPNVNSTGVNMMSNVHLQQNNYGVKSVGQGYGVGQSMRLGLGGNAPVSIPQQSQSVKQLLPSGNGRSYGLGSEQRTQAPARYSLQSPNAPSLSSGQLKSPSLSQSQASRVLGQSSSKPTAAATGPPPPNTSSTQKWKICTICNELFPENVYSVHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLIHGLSCPYCRSTFNDVEKMAAHMRMVHVDEEMGPKTDSTLSFDLTLQQGSHTNIHLLVTTYNLRDAPAESVAYHAQNNPPIPPKPQPKVQEKADIPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDKTNAPSRLNQSPGLAPVKRTYEQMEFPLLKKRKLDEDSDSPGFFEEKPEEPVVLALDPKGHEDDSYEARKSFLTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKKCVRDCEKYKPGVLLGFNMKELNKVKHEMDFDAEWLFENHDEKDSRVNASKTADKKLNLGKEDDSSSDSFENLEEESNGSDSPFDPVFEVEPKIPNDNPEEHIPKVISEDALESEKLDQKAEDGSKYETIHLTEEPTKLMHDASDSEVDQDDVVEWKDGASPSESGPGSQQVSDFEDNTCEMKAGTWSDESSQSEDARSSKPAAKKKATVQGDREQLKWKNSSYGKVEGFWSKDQSQWKNATENDERLSTPQIEWQNSTIDSEDGEQFDSMADGVADPMHGSLTGVKLSSQQA", "length": 1102, "header": "tr|E1BCZ9-1|E1BCZ9_BOVIN Isoform 1 of Activity-dependent neuroprotector homeobox protein OS=Bos taurus OX=9913 GN=ADNP PE=4 SV=1 CANONICAL=E1BCZ9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T1U8-1", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9/entry#A0AAA9T1U8-1", "sequence": { "sequence": "MRRTKNSTTCSRHWSAERARFSGTAPPGARGTAALTGCTCRKVRLGRRVHLDSCQPTATSSGILTAVCRENASTTSRRQKTLSKSWLTPEAQDYRTKPFCCSACPFSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTFNADKKTLETHIKIFHAPNASAPSSSLSTFKDKSKSDGLKPKQADSVEQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKAGEKSLNGAVPLGTNAREESSIHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLIAPKPQEKKGMGLQSRIGSLASGNVRSLPSQQMVNRLSIPKPNVNSTGVNMMSNVHLQQNNYGVKSVGQGYGVGQSMRLGLGGNAPVSIPQQSQSVKQLLPSGNGRSYGLGSEQRTQAPARYSLQSPNAPSLSSGQLKSPSLSQSQASRVLGQSSSKPTAAATGPPPPNTSSTQKWKICTICNELFPENVYSVHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLIHGLSCPYCRSTFNDVEKMAAHMRMVHVDEEMGPKTDSTLSFDLTLQQGSHTNIHLLVTTYNLRDAPAESVAYHAQNNPPIPPKPQPKVQEKADIPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDKTNAPSRLNQSPGLAPVKRTYEQMEFPLLKKRKLDEDSDSPGFFEEKPEEPVVLALDPKGHEDDSYEARKSFLTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKKCVRDCEKYKPGVLLGFNMKELNKVKHEMDFDAEWLFENHDEKDSRVNASKTADKKLNLGKEDDSSSDSFENLEEESNGSDSPFDPVFEVEPKIPNDNPEEHIPKVISEDALESEKLDQKAEDGSKYETIHLTEEPTKLMHDASDSEVDQDDVVEWKDGASPSESGPGSQQVSDFEDNTCEMKAGTWSDESSQSEDARSSKPAAKKKATVQGDREQLKWKNSSYGKVEGFWSKDQSQWKNATENDERLSTPQIEWQNSTIDSEDGEQFDSMADGVADPMHGSLTGVKLSSQQA", "length": 1127, "header": "tr|A0AAA9T1U8-1|E1BCZ9_BOVIN Computationally mapped isoform of Activity-dependent neuroprotector homeobox protein OS=Bos taurus OX=9913 GN=ADNP PE=4 SV=1 CANONICAL=E1BCZ9-1" }, "locus": { "chromosome": "13", "start_pos": 78823840, "end_pos": 78820129, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117612.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117612.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090530.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090530.1" } ] } }, { "isoform_ac": "E1BCZ9-1", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9/entry#E1BCZ9-1", "sequence": { "sequence": "MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACPFSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTFNADKKTLETHIKIFHAPNASAPSSSLSTFKDKSKSDGLKPKQADSVEQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKAGEKSLNGAVPLGTNAREESSIHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLIAPKPQEKKGMGLQSRIGSLASGNVRSLPSQQMVNRLSIPKPNVNSTGVNMMSNVHLQQNNYGVKSVGQGYGVGQSMRLGLGGNAPVSIPQQSQSVKQLLPSGNGRSYGLGSEQRTQAPARYSLQSPNAPSLSSGQLKSPSLSQSQASRVLGQSSSKPTAAATGPPPPNTSSTQKWKICTICNELFPENVYSVHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLIHGLSCPYCRSTFNDVEKMAAHMRMVHVDEEMGPKTDSTLSFDLTLQQGSHTNIHLLVTTYNLRDAPAESVAYHAQNNPPIPPKPQPKVQEKADIPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDKTNAPSRLNQSPGLAPVKRTYEQMEFPLLKKRKLDEDSDSPGFFEEKPEEPVVLALDPKGHEDDSYEARKSFLTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKKCVRDCEKYKPGVLLGFNMKELNKVKHEMDFDAEWLFENHDEKDSRVNASKTADKKLNLGKEDDSSSDSFENLEEESNGSDSPFDPVFEVEPKIPNDNPEEHIPKVISEDALESEKLDQKAEDGSKYETIHLTEEPTKLMHDASDSEVDQDDVVEWKDGASPSESGPGSQQVSDFEDNTCEMKAGTWSDESSQSEDARSSKPAAKKKATVQGDREQLKWKNSSYGKVEGFWSKDQSQWKNATENDERLSTPQIEWQNSTIDSEDGEQFDSMADGVADPMHGSLTGVKLSSQQA", "length": 1102, "header": "tr|E1BCZ9-1|E1BCZ9_BOVIN Isoform 1 of Activity-dependent neuroprotector homeobox protein OS=Bos taurus OX=9913 GN=ADNP PE=4 SV=1 CANONICAL=E1BCZ9-1" }, "locus": { "chromosome": "13", "start_pos": 78828371, "end_pos": 78820129, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000445.4", "url": "https://www.ensembl.org/id/ENSBTAT00000000445.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000445.2", "url": "https://www.ensembl.org/id/ENSBTAP00000000445.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:533757", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533757", "resource": "KEGG Pathway" }, { "id": "R-BTA-9940465", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9940465", "resource": "Reactome", "description": "ChAHP complex assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M3B615-1", "protein_name": "Activity-dependent neuroprotector homeobox b isoform X1", "gene_name": "adnpb", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRAHTHLCTSGRRMFQLPVNNLSSLRKARKNVKKVLGDIGLDFCKEHVDDYKDFVPNEFYLKNTTWDDVCMWDPSMTKSQDYRSKPFCCSGCTFSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTYNGNKKTLETHIRLFHMPNVVRQNTGGLHGAGVGLKDGARLEKTRDNIEQAVYYCKKCTYRDPLYNVVRKHIYREHFQHVAAPYLVRPGEKTTTPNGTTAGSGTGSTTDGGVANSMSTAIHCKRCLFVPRTYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRAKPVIMVSPKSQSEKTVGGVMPKSAVVTGVRPLSTQQLSRIVIPKGSLNSSGLLSGVHLKQGVFGLKPGATQSLSIGGQQVQLSIPQQSQTSKPQLSASLRSAVSASASTSILKIPQLNSRVQAAATTVSAVTSKKGNSVIGTSYTQKWKICTICNELFPENVYSSHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPSDTLLNHMLIHGLSCPHCRATFNDVEKMVTHMRGVHPNESVGPRTDSPLTFDLTLQQGNPKNVQLIVTTYNMRDAPEESVAFHAQNNALPPSLQGNKQVTPTIPKIPSDASGAMPVKATPQAAVPYKKDIGKTLCPLCFSILKGPISDSLAHHLRDRHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVSKTQNGRPAPSARVVQAQGAGLKRAGLANFDQTEPKRKKPDDQTGQSPSPSTEKHEEPVVFALDPKGYENESYETRKAFLTQYFNKQPYPTRREVEKLASSLWLWKSDIASHFSNRRRRCLLNCETLNTRVLMGFKMEDVLNLDHPLNFDSKCYFQNHKHDHKRRTTRFRIGRSANAILLRQKATTNGDLQQKHEMLPRVSSKALLYSNGQNAIIGSNCFDSVKSTLKSGALVNSEPISVDSDSDNEGNVQDASLTALSLSHEEPATNDKVEGSDSDVRENAHSENGYGSTDLLNETSQQDDECQSGITNKLEQSETQLTEQQV", "length": 1016 }, "evidence": [ { "id": "E1BCZ9", "url": "https://omabrowser.org/oma/group/E1BCZ9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0YNF3-1", "protein_name": "Activity dependent neuroprotector homeobox", "gene_name": "ADNP", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLATFNQILCKWGSEKVQQQLMMPRKAFLSQKEKQARARERDMLKKRRRRQDYLKRSVDPQKNAETIKWHRDDEKRRENEQVKDKDIKKRWRQDERERRKNVDAMNWRREDEKRENERETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACPFSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTFNADKKTLETHIKIFHAPNANTPSGGISTFKDKNKHDSLKPKQADSVEQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYVAKGGEKSLNGAVPLSSSTREEGSIHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLIAPKPQDKKPMGLPQRMGPLSPGSVRSLSSQQMMNRLTIPKPTLNSAGVNMMSNVHLQQNNYGVKSVPPSYVGQPGGRLSLSGNAPVSIPQQSQTMKQFSSGNGRPYALGEQRSQASARYSLQSANSTSLSSAQLKQTSLSQSQAASRVLGQSGSKSPVAATGPSSVNTSSTQKWKICTICNELFPENVYSVHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLIHGLSCPYCRSTFNDVEKMAAHMRMVHVDEEMGPKTDSTLTFDLTLQQGSLTNIHLLVTTYNLRDAPAESVAYHAQNTPPVPPKPQPKIQEKSDVPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDKGTSSSRLSQSAGVAPVKRTYEHMEFSLMKRRKMDDDDSPSAFEEKPEEPVVLALDPKGHEDDSYEARKTFLTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKKCVRDCEKYKPGVLLGFNMKELNKVKHEMDFDAEWLFENHDEKNSRVNVSKTVDKKINIEKDNESSSDSYENIEEEYNESSSPFGPHISDIGEKASPDSIAENPDDGISKEIIEENTLPSPEKSDQKQEESSKYEEMISAEEQTKLVGDVSDSEGYQDDQDDAVEWKDGASQSESGPGSQQVSDFEDNTSEVKPEVWTDESSQSEDAGSSKPTAETKGGGSESDEEQSKWKNRSYGKVEEFWAKDQSQWKNASEIEESLTNQQMEWQNSTIDSEDGDQFDSVTDGVADPMHSSLSGVELSSQQA", "length": 1231 }, "evidence": [ { "id": "E1BCZ9", "url": "https://omabrowser.org/oma/group/E1BCZ9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HEU6-1", "protein_name": "Activity-dependent neuroprotector homeobox protein", "gene_name": "Adnp", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACPFSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTFNADKKTLETHIKIFHAPNSSAPSSSLSTFKDKNKNDGLKPKQADSVEQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKAGEKSLNGAVPLGTNAREECNIHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRAKPLMLIAPKPQEKKGMGLPPRISSLTSGNVRSLPSQQMVNRLSIPKPNLNSAGVNMMSNVHLQQNNYGVKSVGQSYGVGQSVRLGLGGNAPVSIPQQSQSVKQLLPSGNGRSYGLGAEQRPPAAARYSLQTANTSLPPGQVKSPSVSQSQASRVLGQSGSKPPPAATGPPPSNHCATQKWKICTICNELFPENVYSVHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLIHGLSCPYCRSTFNDVEKMAAHMRMVHIDEEMGPKTDSTLSFDLTLQQGSHTNIHLLVTTYNLRDAPAESVAYHAQNNAPVPPKPQPKVQEKADVPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDKTNAPSRLNQSPGLAPVKRTYEQVEFPLLKKRKLEDDSDSPSCIEEKPEEPVVLALDPKGHEDDSYEARKSFLTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKKCVRDCEKYKPGVLLGFNMKELNKVKHEMDFDAEWLFENHDEKDSRVNASKTVDKKLNLGKEDDSFSDSFEHLEEESNGSGSPFDPVFEVEPKIPSDNPEEHVPKVIPEDALDSEKLDQKEEEDGSKYETVHLTEEPTKLMHDASDSEVDQDDVVEWKDGASPSVSGPGSQQISDFEDNTCEMKTGTWSDESSQSEDARSSKPASKKKATVQEDTEQLKWKNSSYGKVEGFWSKDQSQWENASENAERLPNPQIEWQNSTIDSEDGEQFDSMTDGVADPMHGSLTGVKLSSQQA", "length": 1102 }, "evidence": [ { "id": "E1BCZ9", "url": "https://omabrowser.org/oma/group/E1BCZ9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9H2P0-1", "protein_name": "Activity-dependent neuroprotector homeobox protein", "gene_name": "ADNP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACPFSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTFNADKKTLETHIKIFHAPNASAPSSSLSTFKDKNKNDGLKPKQADSVEQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKAGEKSLNGAVPLGSNAREESSIHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLIAPKPQDKKSMGLPPRIGSLASGNVRSLPSQQMVNRLSIPKPNLNSTGVNMMSSVHLQQNNYGVKSVGQGYSVGQSMRLGLGGNAPVSIPQQSQSVKQLLPSGNGRSYGLGSEQRSQAPARYSLQSANASSLSSGQLKSPSLSQSQASRVLGQSSSKPAAAATGPPPGNTSSTQKWKICTICNELFPENVYSVHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLIHGLSCPYCRSTFNDVEKMAAHMRMVHIDEEMGPKTDSTLSFDLTLQQGSHTNIHLLVTTYNLRDAPAESVAYHAQNNPPVPPKPQPKVQEKADIPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDKTNAPSRLNQSPSLAPVKRTYEQMEFPLLKKRKLDDDSDSPSFFEEKPEEPVVLALDPKGHEDDSYEARKSFLTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKKCVRDCEKYKPGVLLGFNMKELNKVKHEMDFDAEWLFENHDEKDSRVNASKTADKKLNLGKEDDSSSDSFENLEEESNESGSPFDPVFEVEPKISNDNPEEHVLKVIPEDASESEEKLDQKEDGSKYETIHLTEEPTKLMHNASDSEVDQDDVVEWKDGASPSESGPGSQQVSDFEDNTCEMKPGTWSDESSQSEDARSSKPAAKKKATMQGDREQLKWKNSSYGKVEGFWSKDQSQWKNASENDERLSNPQIEWQNSTIDSEDGEQFDNMTDGVAEPMHGSLAGVKLSSQQA", "length": 1102 }, "evidence": [ { "id": "E1BCZ9", "url": "https://omabrowser.org/oma/group/E1BCZ9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JKL8-1", "protein_name": "Activity-dependent neuroprotector homeobox protein", "gene_name": "Adnp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACPFSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTFNADKKTLETHIKIFHAPNSSAPSSSLSTFKDKNKNDGLKPKQADNVEQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKAGEKSLNGAVSLGTNAREECNIHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRAKPLMLIAPKPQEKKSMGLPPRISSLASGNVRSLPSQQMVNRLSIPKPNLNSTGVNMMSNVHLQQNNYGVKSVGQSYGVGQSVRLGLGGNAPVSIPQQSQSVKQLLPSGNGRSYGLGAEQRPPAAARYSLQTANTSSLPPGQVKSPSVSQSQASRVLGQSSSKPPPAATGPPPSNHCATQKWKICTICNELFPENVYSVHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLIHGLSCPYCRSTFNDVEKMAAHMRMVHIDEEMGPKTDSTLSFDLTLQQGSHTNIHLLVTTYNLRDAPAESVAYHAQNNAPVPPKPQPKVQEKADVPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDKTNAPSRLNQSPGLAPVKRTYEQMEFPLLKKRKLEDENDSPGCFEEKPEEPVVLALDPKGHEDDSYEARKSFLTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKKCVRDCEKYKPGVLLGFNMKELNKVKHEMDFDAEWLFENHDEKASRVNASKTVDKKLNLGKEDDSFSDSFEHLEEESNGSGGPFDPVFEVEPKIPSDNAEEPVPKVIPEGALESEKLDQKEEEDGSKYETIHLTEERAKLMHDASDSEVDQDDVVEWKDGASPSESGPGSRQVSDFEDNTCEMKPGTWSDESSQSEDARSSKPAAKKKATVQDDTEQLKWKNSSYGKVEGFWSKDQSQWENASENAERLPNPQIEWQNSTIDSEDGEQFDSMTDGVADPMHGSLTGVKLSSQQA", "length": 1103 }, "evidence": [ { "id": "E1BCZ9", "url": "https://omabrowser.org/oma/group/E1BCZ9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9Z103-1", "protein_name": "Activity-dependent neuroprotector homeobox protein", "gene_name": "Adnp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACPFSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTFNADKKTLETHIKIFHAPNSSAPSSSLSTFKDKNKNDGLKPKQADNVEQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKAGEKSLNGAVSLGTNAREECNIHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRAKPLMLIAPKPQDKKGMGLPPRISSLASGNVRSLPSQQMVNRLSIPKPNLNSTGVNMMSNVHLQQNNYGVKSVGQSYGVGQSVRLGLGGNAPVSIPQQSQSVKQLLPSGNGRSFGLGAEQRPPAAARYSLQTANTSLPPGQVKSPSVSQSQASRVLGQSSSKPPPAATGPPPSNHCATQKWKICTICNELFPENVYSVHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLIHGLSCPYCRSTFNDVEKMAAHMRMVHIDEEMGPKTDSTLSFDLTLQQGSHTNIHLLVTTYNLRDAPAESVAYHAQNNAPVPPKPQPKVQEKADVPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDKTNAPSRLNQSPGLAPVKRTYEQMEFPLLKKRKLEEDADSPSCFEEKPEEPVVLALDPKGHEDDSYEARKSFLTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKKCVRDCEKYKPGVLLGFNMKELNKVKHEMDFDAEWLFENHDEKDSRVNASKTVDKKHNLGKEDDSFSDSFEHLEEESNGSGSPFDPVFEVEPKIPSDNLEEPVPKVIPEGALESEKLDQKEEEEEEEEEDGSKYETIHLTEEPAKLMHDASDSEVDQDDVVEWKDGASPSESGPGSQQISDFEDNTCEMKPGTWSDESSQSEDARSSKPAAKKKATVQDDTEQLKWKNSSYGKVEGFWSKDQSQWENASENAERLPNPQIEWQNSTIDSEDGEQFDSMTDGVADPMHGSLTGVKLSSQQA", "length": 1108 }, "evidence": [ { "id": "E1BCZ9", "url": "https://omabrowser.org/oma/group/E1BCZ9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "E1BCZ9", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BCZ9", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "E1BCZ9", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BCZ9", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9" } ], "pmid": "" }, { "name": "beta-catenin binding", "id": "GO:0008013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013", "evidence": [ { "database": "UniProtKB", "id": "E1BCZ9", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BCZ9", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BCZ9", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "E1BCZ9", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulator complex", "id": "GO:0090575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090575", "evidence": [ { "database": "UniProtKB", "id": "E1BCZ9", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BCZ9", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BCZ9", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9" } ], "pmid": "" }, { "name": "neuron differentiation", "id": "GO:0030182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182", "evidence": [ { "database": "UniProtKB", "id": "E1BCZ9", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "E1BCZ9", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "E1BCZ9", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1030, "end_pos": 1032, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1049, "end_pos": 1051, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1066, "end_pos": 1068, "annotation": "n_glycosylation_sequon" }, { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" }, { "start_pos": 315, "end_pos": 317, "annotation": "n_glycosylation_sequon" }, { "start_pos": 439, "end_pos": 441, "annotation": "n_glycosylation_sequon" }, { "start_pos": 486, "end_pos": 488, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" }, { "start_pos": 674, "end_pos": 676, "annotation": "n_glycosylation_sequon" }, { "start_pos": 707, "end_pos": 709, "annotation": "n_glycosylation_sequon" }, { "start_pos": 857, "end_pos": 859, "annotation": "n_glycosylation_sequon" }, { "start_pos": 887, "end_pos": 889, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCZ9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1102, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCZ9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCZ9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BCZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 512, "end_pos": 540, "start_aa": "Leu", "end_aa": "Met", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BCZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCZ9" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 771, "end_pos": 814, "start_aa": "Leu", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1030, "end_pos": 1032 }, { "start_pos": 1049, "end_pos": 1051 }, { "start_pos": 1066, "end_pos": 1068 }, { "start_pos": 132, "end_pos": 134 }, { "start_pos": 315, "end_pos": 317 }, { "start_pos": 439, "end_pos": 441 }, { "start_pos": 486, "end_pos": 488 }, { "start_pos": 50, "end_pos": 52 }, { "start_pos": 674, "end_pos": 676 }, { "start_pos": 707, "end_pos": 709 }, { "start_pos": 857, "end_pos": 859 }, { "start_pos": 887, "end_pos": 889 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BD77-1", "uniprot_ac": "E1BD77", "uniprot_id": "E1BD77_BOVIN", "mass": { "chemical_mass": 272492.0, "monoisotopic_mass": 272492.0 }, "refseq": { "ac": "XP_002690489", "name": "zinc finger homeobox protein 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690489" }, "gene_names": [ { "name": "ZFHX2", "type": "recommended", "evidence": [ { "id": "E1BD77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD77" } ] }, { "name": "ZFHX2", "type": "synonym", "evidence": [ { "id": "XP_002690489", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690489" } ] } ], "protein_names": [ { "name": "Zinc finger homeobox 2", "type": "synonym", "evidence": [ { "id": "E1BD77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD77/entry#names_and_taxonomy" } ] }, { "name": "zinc finger homeobox protein 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002690489", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690489" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BD77", "url": "https://www.uniprot.org/uniprotkb/E1BD77" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZFHX2", "url": "https://www.uniprot.org/uniprotkb/E1BD77", "locus": { "chromosome": "10", "start_pos": 21424338, "end_pos": 21405142, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007053", "url": "https://www.ensembl.org/id/ENSBTAG00000007053" } ] } } ], "crossref": [ { "id": "ENSBTAG00000007053", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007053", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539758", "url": "https://www.ncbi.nlm.nih.gov/gene/539758", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003604", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003604", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051968", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051968", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539758", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539758", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PDTHLPQ", "url": "https://omabrowser.org/oma/group/PDTHLPQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BD77", "url": "https://www.orthodb.org/?gene=E1BD77", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45891", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45891", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45891:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45891:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24056", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24056", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002690489", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690489", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T3I2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3I2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD77", "url": "https://www.uniprot.org/uniprotkb/E1BD77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD77-1", "url": "https://www.uniprot.org/uniprotkb/E1BD77-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATLNLSSDTGTTPSPGHDAPSLPLDTSSPSTPSDPVTKDPPDAPSPSESMRSLEAGGQPLESGCGLVPPKEIGEPQEEPGCGGFPPKDLGVDEDKEQEEEEEGELPPVDLSDHLFFTTGGEACLVAKLFPAGDSELPLPKGFPRGEAGVKQESSLPLLAHLPPVHLTALHVQHGFDPIQGFSSSDQILSHDTSAPSPATCEGRDGAFWSYQLAPNPPGDPKDGPTGSRGGDPRALFWLCLLCRLGFSRHQAFVGHTRSHGVKLTAAQHQGLLGNPAVLQEGDEACMALLSFLEPNLPARPLERPLDNSSTVNAEANAAQTKNGPPMAEAQAPVPPMDEVMALSPPSPETTPATWDPSPTQAKESPTLAGEAGPDWFPEGHEEDGGLCPPLNQSSPASKEGGTLPALGGSPEDPGDPAQPYRLADDYSLAPSAFQGLSLSSHMSLLHSRNSCKTLKCPKCNWHYKYQQTLDVHMREKHPESNSHCSYCTAGGAHPRLARGESYNCGYKPYRCEVCNYSTTTKGNLSIHMQSDKHLANLQGFQAGPGGQGSPQEAVVPPPAGDKEPKTKSSWQCKVCSYETNISRNLRIHMTSEKHLQNVLMLHQGLPLGLPPGLVGPSPPPQAGAAPATPPDLFQYFGPQALGQPQAPLPGPGLRPDKPLEAQLLLNGFHHLGAPARKFPAPAPGSPSPDTHLPQSQLLGALSDGLPTSPPPDDSPSLKVFRCLVCQAFSTDSLELLLYHCSMGRSLPEAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTDKHAQKYQLAAHLREGGGAMGTPSPVPLGDGAPYGSVPTLHLRCNICDFESNSKEKMQLHARGAAHEENSQIYKFLLEMEGTATAGPELGLFRCLLCAWETPSRLAVLQHLRAPAHRDAQAQRRLQLLQRGPATDEGLPALQSILSFSHGQLRPRGKTPVTLLAGPPTPEKDAQSKTEQLVSEEAENKTGPLGDSANQTTAFCCPFCSFLSPESEQVRAHALSQHAVQPTFRCPLCQEQLVGRPALHFHLSHLHNVVPECVERLLLVATTVEMTLTTKVLPGPALSPLGDGPEPPSPAPEPVPSRAQAAEGPHLTPEASPDPLPEPPPPSVEAPDKPTGSPDQPPSPAQSPAPRPDAQAEEVAPPPAMAEEEEGAGGEPRPAEPAPADSRHPLTYRKTTNFALDKFLDPARPYKCTVCKESFTQKNILLVHYNSVSHLHKMKKAAIDPSGPAREAGTTPATAAATDKPFKCTVCRVSYNQSSTLEIHMRSVLHQTRSRGAKTDAKAEGPERGPEEPKEGETEGEAGPEKKGPEPGGFLSGLPFLSPPPPPLDLHRFPAPLFTPPVLPPFPLMPESLLKLQQQQLLLPFYLHDLKVGPKLALAGPAPLLSLPAAAPPPPPPPPKAELAEQEWERPPTTEEGAEAGPPSPLHPTPNEAARTAAKALLENFGFELVIQYNEGKQTVPPPPTPPPPEALGGGDKLACRACGKLFSNMLILKTHEEHVHRRFLPFEALSRYAAQFRKSYDSLYPPPAESPKPPDGPLDSPAPQLGPPFLVPEPEVGGARPPEERGRAGGRWPPEEDESARGNLPPLVPAGRRFSRTKFTEFQTQALQSFFETSAYPKDGEVERLASLLGLASRVVVVWFQNARQKARKNASDGGPAPSGGGTGGASGCRRCHATFSCVFDLVRHLKKCYDDQPADDEEEEAERGEEEEEAEDDAEEEQGPEPPAGPEGPPPEPPDREDLGQAEATKPEGKEPEGRAPPSPSPVHTCDQCALSFPNQDLLANHRRLHFLPPVQPSAAPHLLDLPMLVFGERNPLVAGTPPVPPLKRKHEDGSLSPTGSEVGVGGEGEPPRDKRLRTTILPEQLEILYRWYMQDSNPTRKMLDCISEEVGLKKRVVQVWFQNTRARERKGQFRSTPGGVPNPAVKPPITPSPAPFPKFNLLLGKADDGAGREAPKRDAPALPYPTVTPAAGPLPFLPPGKEPPTLTPEPLLPLPAPPPPCEDEGPEEPSKASPESEACSPSAGDLSDSSASSLAEPESPGAGGASGGPGGGGGVPDGMGQRRYRTQMSSLQLKIMKACYEAYRTPTMQECEVLGEEIGLPKRVIQVWFQNARAKEKKAKLQGAAVGGAGGSSESPLAAQRTDCPYCDVKYDFYVSCRGHLFSRQHLAKLKEAVRAQLKSESKCYDLAPAPEAAPAPKAPPATAPASVPLGAAPALPRLAPVLLSGPALAQPPLGSLAPFSSGPAASSGLLGLATSVLPATTVVQTAGPGCPLPQRPVPDQTKPSPAGTTDSAPGPPPEPSGDKVSGERKPVAAPTNSSADALKNLKALKATVPALLGGQFLPFPLPPAGGATPPAVFGPQLPGAYFQQLYGMKKGLFPMNPVIPQTLIGLLPNALLPPPPQAPEPTATAPPKPPELPAPREGEAGEADELLTGSPGISTVDVTHRYLCRQCKMAFDGEAPATAHQRSFCFFGRGSGGSVPAPLRVPVCTYHCLACEVLLSGREALASHLRSSAHRRKAAPPPGGPPGTATNAATAATAAVAFAKEEARLPHTDSNPKTTTTSTLLAL", "length": 2571, "header": "tr|E1BD77-1|E1BD77_BOVIN Isoform 1 of Zinc finger homeobox 2 OS=Bos taurus OX=9913 GN=ZFHX2 PE=4 SV=1 CANONICAL=E1BD77-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T3I2-1", "url": "https://www.uniprot.org/uniprotkb/E1BD77/entry#A0AAA9T3I2-1", "sequence": { "sequence": "MATLNLSSDTGTTPSPGHDAPSLPLDTSSPSTPSDPVTKDPPDAPSPSESMRSLEAGGQPLESGCGLVPPKEIGEPQEEPGCGGFPPKDLGVDEDKEQEEEEEGELPPVDLSDHLFFTTGGEACLVAKLFPAGDSELPLPKGFPRGEAGVKQESSLPLLAHLPPVHLTALHVQHGFDPIQGFSSSDQILSHDTSAPSPATCEGRDGAFWSYQLAPNPPGDPKDGPTGSRGGDPRALFWLCLLCRLGFSRHQAFVGHTRSHGVKLTAAQHQGLLGNPAVLQEGDEACMALLSFLEPNLPARPLERPLDNSSTVNAEANAAQTKNGPPMAEAQAPVPPMDEVMALSPPSPETTPATWDPSPTQAKESPTLAGEAGPDWFPEGHEEDGGLCPPLNQSSPASKEGGTLPALGGSPEDPGDPAQPYRLADDYSLAPSAFQGLSLSSHMSLLHSRNSCKTLKCPKCNWHYKYQQTLDVHMREKHPESNSHCSYCTAGGAHPRLARGESYNCGYKPYRCEVCNYSTTTKGNLSIHMQSDKHLANLQGFQAGPGGQGSPQEAVVPPPAGDKEPKTKSSWQCKVCSYETNISRNLRIHMTSEKHLQNVLMLHQGLPLGLPPGLVGPSPPPQAGAAPATPPDLFQYFGPQALGQPQAPLPGPGLRPDKPLEAQLLLNGFHHLGAPARKFPAPAPGSPSPDTHLPQSQLLGALSDGLPTSPPPDDSPSLKVFRCLVCQAFSTDSLELLLYHCSMGRSLPEAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTDKHAQKYQLAAHLREGGGAMGTPSPVPLGDGAPYGSVPTLHLRCNICDFESNSKEKMQLHARGAAHEENSQIYKFLLEMEGTATAGPELGLFRCLLCAWETPSRLAVLQHLRAPAHRDAQAQRRLQLLQRGPATDEGLPALQSILSFSHGQLRPRGKTPVTLLAGPPTPEKDAQSKTEQLVSEEAENKTGPLGDSANQTTAFCCPFCSFLSPESEQVRAHALSQHAVQPTFRCPLCQEQLVGRPALHFHLSHLHNVVPECVERLLLVATTVEMTLTTKVLPGPALSPLGDGPEPPSPAPEPVPSRAQAAAQSPAPRPDAQAEEVAPPPAMAEEEEGAGGEPRPAEPAPADSRHPLTYRKTTNFALDKFLDPARPYKCTVCKESFTQKNILLVHYNSVSHLHKMKKAAIDPSGPAREAGTTPATAAATDKPFKCTVCRVSYNQSSTLEIHMRSVLHQTRSRGAKTDAKAEGPERGPEEPKEGETEGEAGPEKKGPEPGGFLSGLPFLSPPPPPLDLHRFPAPLFTPPVLPPFPLMPESLLKLQQQQLLLPFYLHDLKVGPKLALAGPAPLLSLPAAAPPPPPPPPKAELAEQEWERPPTTEEGAEAGPPSPLHPTPNEAARTAAKALLENFGFELVIQYNEGKQTVPPPPTPPPPEALGGGDKLACRACGKLFSNMLILKTHEEHVHRRFLPFEALSRYAAQFRKSYDSLYPPPAESPKPPDGPLDSPAPQLGPPFLVPEPEVGGARPPEERGRAGGRWPPEEDESARGNLPPLVPAGRRFSRTKFTEFQTQALQSFFETSAYPKDGEVERLASLLGLASRVVVVWFQNARQKARKNASDGGPAPSGGGTGGASGCRRCHATFSCVFDLVRHLKKCYDDQPADDEEEEAERGEEEEEAEDDAEEEQGPEPPAGPEGPPPEPPDREDLGQAEATKPEGKEPEGRAPPSPSPVHTCDQCALSFPNQDLLANHRRLHFLPPVQPSAAPHLLDLPMLVFGERNPLVAGTPPVPPLKRKHEDGSLSPTGSEVGVGGEGEPPRDKRLRTTILPEQLEILYRWYMQDSNPTRKMLDCISEEVGLKKRVVQVWFQNTRARERKGQFRSTPGGVPNPAVKPPITPSPAPFPKFNLLLGKADDGAGREAPKRDAPALPYPTVTPAAGPLPFLPPGKEPPTLTPEPLLPLPAPPPPCEDEGPEEPSKASPESEACSPSAGDLSDSSASSLAEPESPGAGGASGGPGGGGGVPDGMGQRRYRTQMSSLQLKIMKACYEAYRTPTMQECEVLGEEIGLPKRVIQVWFQNARAKEKKAKLQGAAVGGAGGSSESPLAAQRTDCPYCDVKYDFYVSCRGHLFSRQHLAKLKEAVRAQLKSESKCYDLAPAPEAAPAPKAPPATAPASVPLGAAPALPRLAPVLLSGPALAQPPLGSLAPFSSGPAASSGLLGLATSVLPATTVVQTAGPGCPLPQRPVPDQTKPSPAGTTDSAPGPPPEPSGDKVSGERKPVAAPTNSSADALKNLKALKATVPALLGGQFLPFPLPPAGGATPPAVFGPQLPGAYFQQLYGMKKGLFPMNPVIPQTLIGLLPNALLPPPPQAPEPTATAPPKPPELPAPREGEAGEADELLTGSPGISTVDVTHRYLCRQCKMAFDGEAPATAHQRSFCFFGRGSGGSVPAPLRVPVCTYHCLACEVLLSGREALASHLRSSAHRRKAAPPPGGPPGTATNAATAATAAVAFAKEEARLPHTDSNPKTTTTSTLLAL", "length": 2533, "header": "tr|A0AAA9T3I2-1|E1BD77_BOVIN Computationally mapped isoform of Zinc finger homeobox 2 OS=Bos taurus OX=9913 GN=ZFHX2 PE=4 SV=1 CANONICAL=E1BD77-1" }, "locus": { "chromosome": "10", "start_pos": 21423334, "end_pos": 21410503, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103119.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103119.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092333.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092333.1" } ] } }, { "isoform_ac": "E1BD77-1", "url": "https://www.uniprot.org/uniprotkb/E1BD77/entry#E1BD77-1", "sequence": { "sequence": "MATLNLSSDTGTTPSPGHDAPSLPLDTSSPSTPSDPVTKDPPDAPSPSESMRSLEAGGQPLESGCGLVPPKEIGEPQEEPGCGGFPPKDLGVDEDKEQEEEEEGELPPVDLSDHLFFTTGGEACLVAKLFPAGDSELPLPKGFPRGEAGVKQESSLPLLAHLPPVHLTALHVQHGFDPIQGFSSSDQILSHDTSAPSPATCEGRDGAFWSYQLAPNPPGDPKDGPTGSRGGDPRALFWLCLLCRLGFSRHQAFVGHTRSHGVKLTAAQHQGLLGNPAVLQEGDEACMALLSFLEPNLPARPLERPLDNSSTVNAEANAAQTKNGPPMAEAQAPVPPMDEVMALSPPSPETTPATWDPSPTQAKESPTLAGEAGPDWFPEGHEEDGGLCPPLNQSSPASKEGGTLPALGGSPEDPGDPAQPYRLADDYSLAPSAFQGLSLSSHMSLLHSRNSCKTLKCPKCNWHYKYQQTLDVHMREKHPESNSHCSYCTAGGAHPRLARGESYNCGYKPYRCEVCNYSTTTKGNLSIHMQSDKHLANLQGFQAGPGGQGSPQEAVVPPPAGDKEPKTKSSWQCKVCSYETNISRNLRIHMTSEKHLQNVLMLHQGLPLGLPPGLVGPSPPPQAGAAPATPPDLFQYFGPQALGQPQAPLPGPGLRPDKPLEAQLLLNGFHHLGAPARKFPAPAPGSPSPDTHLPQSQLLGALSDGLPTSPPPDDSPSLKVFRCLVCQAFSTDSLELLLYHCSMGRSLPEAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTDKHAQKYQLAAHLREGGGAMGTPSPVPLGDGAPYGSVPTLHLRCNICDFESNSKEKMQLHARGAAHEENSQIYKFLLEMEGTATAGPELGLFRCLLCAWETPSRLAVLQHLRAPAHRDAQAQRRLQLLQRGPATDEGLPALQSILSFSHGQLRPRGKTPVTLLAGPPTPEKDAQSKTEQLVSEEAENKTGPLGDSANQTTAFCCPFCSFLSPESEQVRAHALSQHAVQPTFRCPLCQEQLVGRPALHFHLSHLHNVVPECVERLLLVATTVEMTLTTKVLPGPALSPLGDGPEPPSPAPEPVPSRAQAAEGPHLTPEASPDPLPEPPPPSVEAPDKPTGSPDQPPSPAQSPAPRPDAQAEEVAPPPAMAEEEEGAGGEPRPAEPAPADSRHPLTYRKTTNFALDKFLDPARPYKCTVCKESFTQKNILLVHYNSVSHLHKMKKAAIDPSGPAREAGTTPATAAATDKPFKCTVCRVSYNQSSTLEIHMRSVLHQTRSRGAKTDAKAEGPERGPEEPKEGETEGEAGPEKKGPEPGGFLSGLPFLSPPPPPLDLHRFPAPLFTPPVLPPFPLMPESLLKLQQQQLLLPFYLHDLKVGPKLALAGPAPLLSLPAAAPPPPPPPPKAELAEQEWERPPTTEEGAEAGPPSPLHPTPNEAARTAAKALLENFGFELVIQYNEGKQTVPPPPTPPPPEALGGGDKLACRACGKLFSNMLILKTHEEHVHRRFLPFEALSRYAAQFRKSYDSLYPPPAESPKPPDGPLDSPAPQLGPPFLVPEPEVGGARPPEERGRAGGRWPPEEDESARGNLPPLVPAGRRFSRTKFTEFQTQALQSFFETSAYPKDGEVERLASLLGLASRVVVVWFQNARQKARKNASDGGPAPSGGGTGGASGCRRCHATFSCVFDLVRHLKKCYDDQPADDEEEEAERGEEEEEAEDDAEEEQGPEPPAGPEGPPPEPPDREDLGQAEATKPEGKEPEGRAPPSPSPVHTCDQCALSFPNQDLLANHRRLHFLPPVQPSAAPHLLDLPMLVFGERNPLVAGTPPVPPLKRKHEDGSLSPTGSEVGVGGEGEPPRDKRLRTTILPEQLEILYRWYMQDSNPTRKMLDCISEEVGLKKRVVQVWFQNTRARERKGQFRSTPGGVPNPAVKPPITPSPAPFPKFNLLLGKADDGAGREAPKRDAPALPYPTVTPAAGPLPFLPPGKEPPTLTPEPLLPLPAPPPPCEDEGPEEPSKASPESEACSPSAGDLSDSSASSLAEPESPGAGGASGGPGGGGGVPDGMGQRRYRTQMSSLQLKIMKACYEAYRTPTMQECEVLGEEIGLPKRVIQVWFQNARAKEKKAKLQGAAVGGAGGSSESPLAAQRTDCPYCDVKYDFYVSCRGHLFSRQHLAKLKEAVRAQLKSESKCYDLAPAPEAAPAPKAPPATAPASVPLGAAPALPRLAPVLLSGPALAQPPLGSLAPFSSGPAASSGLLGLATSVLPATTVVQTAGPGCPLPQRPVPDQTKPSPAGTTDSAPGPPPEPSGDKVSGERKPVAAPTNSSADALKNLKALKATVPALLGGQFLPFPLPPAGGATPPAVFGPQLPGAYFQQLYGMKKGLFPMNPVIPQTLIGLLPNALLPPPPQAPEPTATAPPKPPELPAPREGEAGEADELLTGSPGISTVDVTHRYLCRQCKMAFDGEAPATAHQRSFCFFGRGSGGSVPAPLRVPVCTYHCLACEVLLSGREALASHLRSSAHRRKAAPPPGGPPGTATNAATAATAAVAFAKEEARLPHTDSNPKTTTTSTLLAL", "length": 2571, "header": "tr|E1BD77-1|E1BD77_BOVIN Isoform 1 of Zinc finger homeobox 2 OS=Bos taurus OX=9913 GN=ZFHX2 PE=4 SV=1 CANONICAL=E1BD77-1" }, "locus": { "chromosome": "10", "start_pos": 21423334, "end_pos": 21410503, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009273.4", "url": "https://www.ensembl.org/id/ENSBTAT00000009273.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009273.2", "url": "https://www.ensembl.org/id/ENSBTAP00000009273.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1469, "start_aa": "Thr", "end_pos": 1469, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1469", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1971, "start_aa": "Thr", "end_pos": 1971, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1971", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2356, "start_aa": "Thr", "end_pos": 2356, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2356", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 32, "start_aa": "Thr", "end_pos": 32, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr32", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 360, "start_aa": "Thr", "end_pos": 360, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr360", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 629, "start_aa": "Thr", "end_pos": 629, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr629", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 803, "start_aa": "Thr", "end_pos": 803, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr803", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 949, "start_aa": "Thr", "end_pos": 949, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr949", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539758", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539758", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZJ69-1", "protein_name": "Zinc finger homeobox 2", "gene_name": "ZFHX2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATLNSSSTACATPSPGHDALSPPLDASPPSTPSDPVTKDPPAAPSTSESMRSSEPGGQPLESGCGLIPPKEIGEPQEEPGCGGFLPKDLGVEEDREQEEEGGGLPPVDLSDHLFFTAGGEACLVARLSLPGGSELPLPKGFPWGEAGVKEEPSLPLRAHPPPAHLTALHIQHGFDPIQGFSSSDQILSHDTSVPSPATCEGRDGAFWSYQLAPNPPGDPKDGPMGSRGGDPRARFWLCLLCRLGFGSPQAFVGHTESHGVKLTAAQHQGLLGNPAMLWEGGEGCMALLSFLEPKAPARSLDNSSTVNMEASAAQTEDGPPAAEALAPVLPVEEVMALSPPSPSTTPATWNPSPTQAKELPMAAGEAGADWFPEGHEEDGGLCTPLNQSSPTSKEGGTLPAPGGSPEDPSDPPQPYRLADDYTPVPAAFQGLSLSSHMSLLHSRNSCKTLKCPKCNWHYKYQQTLDVHMREKHPESNSHCSYCSAGGAHPRLARGESYNCGYKPYRCDVCNYSTTTKGNLSIHMQSDKHLANLQGFQAGPGGQGSPPEAALPPSTGDKEPKAKSSWQCKVCSYETNISRNLRIHMTSEKHMQNVLMLHQGLPLGLPPGLVAPGAPTPAGAAPTTPPELFQYFGSQALGQPQAPLPGPGLRPDKPLEAQLLLNGFHHLGAPARKFPTPAPGSPSPDAHLPQSQLLGSLSDGLPTSPPPDDNPSLKVFRCLVCQAFSTDSLELLLYHCSVGRSLPEAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTDKHAQKYQLAAHLREGGGVTGTPSPVPLGDGAPYGSVPPLHLRCNICDFESNSKEKMQLHARGAAHEENSQIYKFLLEMEGAVAGVELGLFRCLLCAWETPSRLAVLQHLRAPAHRDAQAQRRLQLLQSGPAADEGLSALQSILSFSHGQLRTPGKAPVTPLAEPPTPEKDAQNKMEQLASEEAENKTGPPGDSANQTTVFCCPYCSFLSPESEQVRAHALSQHAVQPKYRCPLCQEQLVGRPALHFHLSHLHNVVPECVERLLLVATTVEMTLTTKVLPGPALSPLGDGPEPPAPGPEPEPSRDQAAEGLHLTLEASPDPLPEPLPPSAEAPDKPMGSPDQAPSPAPSPVPRPEAQADEVAHSATAEEEEGAGGEPRPAEPAPADSRHPLTYRKTTNFALDKFLDPARPYKCTVCKESFTQKNILLVHYNSVSHLHKMKKAAIDPSAPARGEAGAAPATAAATTDKPFKCTVCRVSYNQSSTLEIHMRSVLHQTRSRGAKTDAKAEAPERGPEEPKEGETEGEVGTEKKGPDSGGFVSGLPFLSPPPPPLDLHRFPAPLFTPPVLPPFPLVPESLLKLQQQQLLLPFYLHDLKVGPKLTLAGPAPLLSLPAAAPPPPPPPPKAELVEREWERPPQTQEGNEAGPTSPPHPTPNEAARTAAKALLENFGFELVIQYNEGKQAVPPPPTPPPPEAPGGGDKLACGACGKLFSNMLILKTHEEHVHRRFLPFEALSRYAAQFRKSYDSLYPPPAESPKPPDGSLDSPAPQLGPPFLVPEPEAGGGRPPEERSRAGGHWPPEEEESSRGNLPPLVHAGRRFSRTKFTEFQTQALQSFFETSAYPKDGEVERLASLLGLASRVVVVWFQNARQKARKNASEGGPVPSGGGAGSASGCRRCHATFSCVFDLVRHLKKCYDDQPPEEEEEETERGEEEEDVEEEDAEEERGPEAPAGPEGPSPEPPDREELSQAEAIKPGGKEPEGRAPPSPSPVHACDQCAMSFPSQDLLTSHRRLHFLPPVQPGAAPHLLDLPLLVFGERNPLVAGTPPVPGPALKRKHEDGSLSPTGSEAGGGGEGEPPRDKRLRTTILPEQLEILYRWYMQDSNPTRKMLDCISEEVGLKKRVVQVWFQNTRARERKGQFRSTPGGVPNPAVKTPITPSPAPFPKFNLLLGKVEDGAGREAPKREAPAFPCSTVTPAAGPLPFLPPGKEATTPIPEPPLPLPPPPPPSEDEGPEEPSKASPESEACSPAAGDLSDSSASSLAEPESPGAGGTSGGPGGGAGVPDGMGQRRYRTQMSSLQLKIMKACYEAYRTPTMQECEVLGEEIGLPKRVIQVWFQNARAKEKKAKLQGAAVGGAGGSSEGPLGTQRTDCPYCDIKYDFYVSCRGHLFSRQHLAKLKEAVRAQLKSESKCYDLAPAPAPEAPPATTPASVPLGAAPALPRLAPVLLSGPTLAQPPLGSLAPFSSGPAAPSGLLGLATSVLPATTVVQTAGPGCPLPQRPMPDQTNTSTAGTTDPAPGPPTEPSGDKVSGERKPAAAPTNSSTDALKNLKALKATVPALLGGQFLPFPLPPAGGATPPAVFGPQLQGAYFQQLYGMKKGLFPMNPVIPQTLIGLLPNALLQPPPQAPEPTATAPAKPPELPAPGEGEAGEADELLTGSTGISTVDVTHRYLCRQCKMAFDGEALAAAHQRSFCFFGRGSGGPLPPPLRVPICTYHCLACEVLLSGREALASHLRSSAHRRKAAPPPGGPPGTATNAATAATAAVAFAKEEARLPHTDSNPKTTTTSTLLAL", "length": 2565 }, "evidence": [ { "id": "E1BD77", "url": "https://omabrowser.org/oma/group/E1BD77/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZF41-1", "protein_name": "Zinc finger homeobox 2", "gene_name": "Zfhx2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATLSSVSSSGTIPSPGHHVPSPSPETSSSSTSDPVTKDPPDAPSTAESIRSSEPGGEHLESGRDLAPPKEIGEPRHEPGCGPIPPKDLGVSKEEKGILPLDLSNHLLFSAGGQAYLLANLSLSGGSELLLPKGFPWDEASVKEEPSLPLLAHFPSSHLTTLHIQHGFDPVQGFSSSDQILSHDTSAPSLAACEGRDGSFWSYQLVPNPTEDPKDGPMGSRRGDHRAMFWICLLCRLGFGRLQAFIGHTLSHGVKLTPAHHQGLLGSPAVLQEGHDGGMAFLSFLEPKLLTHPSPEVPDTSTVTVKTNGAQAEDGPPEADVQALVLPGEEVMALSPPSPPTALATWDPSPTQAKESPVSRGEAGPDWFPEGQEEDGGLCLPLNQSSPTSKEVAVLPAPAGSPEDTSDPPQSCRLTDDYTPAPAAFQGLSLSSHMSLLHSRNSCKTLKCPKCNWHYKYQQTLDVHMREKHPESNSHCSYCSAGGAHPRLARGESYNCGYKPYRCDVCNYSTTTKGNLSIHMQSDKHLANLQGFQAGPGGQASPPEASLPPPSIGEKEPKTKSSWQCKVCSYETNISRNLRIHMTSEKHMQNVLMLHQGLPLGLPPGLVGPGPPPPPGAAPTNPPELFQYFGPQALGQPQTSMPGPGLRPDKPLEAQLLLNGFHHLGAPARKFPTAAPGSLSPETHLPPSQLLGSSSDGLSTSPSPDDSPPLKVFRCLVCQAFSTDSLELLLYHCSIGRTLPEAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTDKHTQKYQLAAHLREGGGAMGSPSPLSLGDGTSYGGSVSPLHLRCNICDFESNSKEKMQLHARGSAHEENSQIYKFLLEMEGAEAGPEPGLYHCLLCAWDTPSRLAVLQHLRMPAHRDAQAQRRLQLLQSGPAAEEGLSALQSILSFSRGRLQTPGKAPDTPLAQPPTSEKDAQNRTEQRASEVTEDRTGPPRDSANQITVRTGVTGMMKVFCCPYCSFLSPECDQVRVHTLSQHAVQPKYRCPLCQEQLVGRPALHFHLSHLHNVVPECVEKLLLVATTVEMTFATKMLPGPTLNPVEDGLERPAPGPEPTPNRDQVADSSNLAPEASPDPPPPPEPPLAPVEGPMEPSESPQQPPSPASSPVPRPDAQVEELTPLPTMSEEEEGVMGEPRSAEPSPADSRHLTYRKTTNFALDKFLDPARPYKCTVCKESFTQKNILLVHYNSVSHLHKMKKAAIDPSCPARGEAGIPPPTTTASDKPFKCTVCRVSYNQSSTLEIHMRSVLHQTRSRGAKTDARTEGPERSQEELKEGETEGEVGTEKKGPDPSGFMSGLPFLSPPPPPLDLHRFPAPLFTPPVLPPFPLVPESLLKLQQQQLLLPFYLHDLKVGPKLALASPTPMLSLPAANPPPLPAPPKAELAEQEWERPLIAEEGTEAGPSSPPHSSPNEAARTAAKALLENFGFELVIQYNEGKQAVPPPPTPPPPESLGGGDKLACGACGKLFSNMLILKTHEEHVHRRFLPFEALSRYAAQFRKSYDSLYPPPVEPPKPPDGSLESPPQLGPPFVVPEPEVGGIHTSEERGLAGGPWPSEEEEGSRGSVVPVGRRFSRTKFTEFQTQALQSFFETSAYPKDGEVERLASLLGLASRVVVVWFQNARQKARKNACEGGPMTAGGATGGASGCRRCHATFACVFELVRHLKKCFDDQPPAEEEEAERGEEEEEVEEEEVEERNPEPAGRHGDRSPERANAEDVGQAEPTRPESKETEGKAPPSPPAHTCDQCSISFPSQDLLTTHHRLHFLPSVQPSAPSQLLDLPLLVFGERNPVVSGPSSVTGTPLKRKHDDGSLSPTGSEAGGGGEGEPPKDKRLRTTILPEQLEILYRWYMQDSNPTRKMLDCISEEVGLKKRVVQVWFQNTRARERKGQFRSTPGGVAGPAAKPTATPSPAPFPKFNLLLSKIEDETGKEAPKREAPAFPYPTVTPAAAPGPLPFLAPGKEVTAPTPEPPPPLPPSALSEDEGPEEPSKASPESEACSPSAGDLSDSSASSLAEPESPGAGGNGGGPGSGPGVPDGMGQRRYRTQMSSLQLKIMKACYEAYRTPTMQECEVLGEEIGLPKRVIQVWFQNARAKEKKAKLQGTAPAGSGGGSEGPSAAQRTDCPYCDVKYDFYVSCRGHLFSRQHLAKLKEAVRAQLKSESKCYDLAPAPETPLAPKGPPATTPASVPLGASPTLPRLAPVLLPGPTLAQPPLGSIASFNSGPAASSGLLGLATSVLPATTVVQTAGPGRPLPQRPVSNQTNSSTDPSPGPATEPSGDKVSGERKPVATLTNSSTDALKNLKALKATVPALLGGQFLPFPLPPAGGAAPPAVFGPQLQGSYFQQLYGMKKGLFPMNPVIPQTLIGLLPNALLQQPPQAPEPTATAPPKPPELPAPGEGESSEADELLTGSAGISTVDVTHRYLCRQCKMAFDGEAPATAHQRSFCFFGRGSGGSMPAPLRVPICTYHCLACEVLLSGREALASHLRSSAHRRKAAPPPGGPPITVTNSATAVPAAVAFAKEEARLPHTDPNPQTTTTSTLLAL", "length": 2568 }, "evidence": [ { "id": "E1BD77", "url": "https://omabrowser.org/oma/group/E1BD77/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q2MHN3-1", "protein_name": "Zinc finger homeobox protein 2", "gene_name": "Zfhx2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATLNSASPSGTVPSPGHNVRSPPPETSSSSTSDPVTKDPPDAPSTSESIRSSEPGGERLESGSDLDPPKEIGEPQEEPGCGHIPPKDLGVAKEEEEILPLDLSSHLFFAAGGQAYLLANLPLPRGSELSLPKGFPWDEASAKEEPSLPLLTHFPSSHLTTLHIQHGFDPIQGFSSSDQMLSHDTSAPSLAACERRDGSFWSYQLVPNPTEDPKDGPLGSRREDHRAMFWICLLCRLGFGRLQTFIGHTLSHGVKLSPAHHQGLLGSPAVLQEGHDGGMALLSFLEPKFLTRPSPEVPDTSTVTVKTNGAQAEDGPPEADGQALVLPAEEVIALSPPSPPTALATWDPSPTQAKDSPVPRGEAGPDWFPEGQEEDGGLCLPLNQSSPTSKEVAVLPAPAGSPEDTSDPPPSCRLADDYTPAPAAFQGLSLSSHMSLLHSRNSCKTLKCPKCNWHYKYQQTLDVHMREKHPESNSHCSYCSAGGAHPRLARGESYNCGYKPYRCDVCNYSTTTKGNLSIHMQSDKHLANLQGFQAGPGGQASPPEASLPPTSVGDKEPKTKSSWQCKVCSYETNISRNLRIHMTSEKHMQNVLMLHQGLPLGLPPGLVGPGPPPPPGAAPTNPPELFQYFGPQALGQPQTPMPGPGLRPDKPLEAQLLLNGFHHLGAPARKFPTAAPGSLSPETHLPPSQLLGSSSDGLPTSPSPDDSPALKVFRCLVCQAFSTDSLELLLYHCSIGRSLPEAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTDKHTQKYQLAAHLREGGGAMGTPSLLALGDGASYGSISPLHLRCNICDFESNSKEKMQLHTRGSAHEENSQIYKFLLEMEGAEAGPEPGLYHCLLCAWDTPSRLALLQHLRTPAHRDAQAQRRLQLLQNGPAAEEGLSALQSILSFSHGRLQTPGKASDTPLAQPPTSEKDAQNKTEQQASEVTEDRSGPPRDSANQITVFCCPYCSFLSPECDQVRVHTLSQHAVQPKYRCPLCQEQLVGRPALHFHLSHLHNVVPECVEKLLLVATTVEMTFATKMLPGPTLNPVEDGLDHPAPGAEPTPNRDQVAESSNLAPEVSPDPPLEPPLAPVEGSREPSESPDQPPSPAPSPAPRLDAQVEELAPLPTMSEEEEGAMGEPRSAEPTPADSRHPLTYRKTTNFALDKFLDPARPYKCTVCKESFTQKNILLVHYNSVSHLHKMKKAAIDPSGPARGEAGIPPPAATASDKPFKCTVCRVSYNQSSTLEIHMRSVLHQTRSRGAKIDARAEGAERGQEEFKEGETEGEAGTEKKGPDPGGFMSGLPFLSPPPPPLDLHRFSAPLFTPPVLPPFPLVPESLLKLQQQQLLLPFYLHDLKVGPKLALASPTPMLSLPAANPPPLPAPPKAELAEQEWERPLMAEEGTEAGPSSPTHTSPNEAARTAAKALLENFGFELVIQYNEGKQAVPPPPTPPPPESLGGGDKLACGACGKLFSNMLILKTHEEHVHRRFLPFEALSRYAAQFRKSYDSLYPPPVEPPKPPDGCLESPPQLGPPFVVPEPEVGGIHTSEERSLSGGGPWPSEEEEGSRGSLPPAVPVGRRFSRTKFTEFQTQALQSFFETSAYPKDGEVERLASLLGLASRVVVVWFQNARQKARKNACEGGPVTAGGASGGASGCRRCHATFACVFELVRHLKKCYDDQPPEEEEEAERGEEEEEVEEEEAEERNLEPAAARPGGPSPEHADGEDLSQTEPTRPESKESEGKAPPSPPVYACDQCAASFPSQDLLTTHHRLHLLPSVQPSAPPPSQLLDLPLLVFGERNPVVSGTSSVTGTPLKRKHDDGSLSPTGSEAGGGGEGEPPKDKRLRTTILPEQLEILYRWYMQDSNPTRKMLDCISEEVGLKKRVVQVWFQNTRARERKGQFRSTPGGVAGPAVKPTVPPSPAPFPKFNLLLSKIEDETGKEAPKRDAPAFPYPTVTPAVGPLPFLPPGKEAAVPTPEPPPPLPPPALSEDEGPEEPSKASPESEACSPSAGDLSDSSASSLAEPESPGAGGTSGGPGGGTGVPDSMGQRRYRTQMSSLQLKIMKACYEAYRTPTMQECEVLGEEIGLPKRVIQVWFQNARAKEKKAKLQGTAPPGSGGSSEGTSAAQRTDCPYCDVKYDFYVSCRGHLFSRQHLAKLKEAVRAQLKSESKCYDLAPAPETPLAPKGPPATTPASSVPLGASPTLPRLAPVLLPGPTLAQPPLGSIASFNSGPAASSGLLGLATSVLPATTVVQTAGPGRPLPQRPVSNQTNSSTDPTPGPATEPSGDKVSGERKPVATLPNSSTDALKNLKALKATVPALLGGQFLPFPLPPAGGAAPPAVFGPQLQGAYFQQLYGMKKGLFPMNPVIPQTLIGLLPNALLQQPPQAPEPTATAPPKPPELPASGEGESSEADELLTGSTGISTVDVTHRYLCRQCKMAFDGEAPATAHQRSFCFFGRGSGASMPAPLRVPICTYHCLACEVLLSGREALASHLRSSAHRRKAAPPPGGPPITVTNSATAVPAAVAFAKEEARLPHTDPNPKTTTTSTLLAL", "length": 2562 }, "evidence": [ { "id": "E1BD77", "url": "https://omabrowser.org/oma/group/E1BD77/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9C0A1-1", "protein_name": "Zinc finger homeobox protein 2", "gene_name": "ZFHX2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATLNSASTTGTTPSPGHNAPSLPSDTFSSSTPSDPVTKDPPAASSTSENMRSSEPGGQLLESGCGLVPPKEIGEPQEGPDCGHFPPNDPGVEKDKEQEEEEEGLPPMDLSNHLFFTAGGEAYLVAKLSLPGGSELLLPKGFPWGEAGIKEEPSLPFLAYPPPSHLTALHIQHGFDPIQGFSSSDQILSHDTSAPSPAACEERHGAFWSYQLAPNPPGDPKDGPMGNSGGNHVAVFWLCLLCRLGFSKPQAFMDHTQSHGVKLTPAQYQGLSGSPAVLQEGDEGCKALISFLEPKLPARPSSDIPLDNSSTVNMEANVAQTEDGPPEAEVQALILLDEEVMALSPPSPPTATWDPSPTQAKESPVAAGEAGPDWFPEGQEEDGGLCPPLNQSSPTSKEGGTLPAPVGSPEDPSDPPQPYRLADDYTPAPAAFQGLSLSSHMSLLHSRNSCKTLKCPKCNWHYKYQQTLDVHMREKHPESNSHCSYCSAGGAHPRLARGESYNCGYKPYRCDVCNYSTTTKGNLSIHMQSDKHLANLQGFQAGPGGQGSPPEASLPPSAGDKEPKTKSSWQCKVCSYETNISRNLRIHMTSEKHMQNVLMLHQGLPLGLPPGLMGPGPPPPPGATPTSPPELFQYFGPQALGQPQTPLAGPGLRPDKPLEAQLLLNGFHHVGAPARKFPTSAPGSLSPDAHLPPSQLLGSSSDSLPTSPPPDDSLSLKVFRCLVCQAFSTDSLELLLYHCSIGRSLPEAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTDKHAQKYQLAAHLREGGGAMGTPSPASLGDGAPYGSVSPLHLRCNICDFESNSKEKMQLHARGAAHEENSQIYKFLLDMEGAEAGAELGLYHCLLCAWETPSRLAVLQHLRTPAHRDAQAQRRLQLLQNGPTTEEGLAALQSILSFSHGQLRTPGKAPVTPLAEPPTPEKDAQNKTEQLASEETENKTGPSRDSANQTTVYCCPYCSFLSPESSQVRAHTLSQHAVQPKYRCPLCQEQLVGRPALHFHLSHLHNVVPECVEKLLLVATTVEMTFTTKVLSAPTLSPLDNGQEPPTHGPEPTPSRDQAAEGPNLTPEASPDPLPEPPLASVEVPDKPSGSPGQPPSPAPSPVPEPDAQAEDVAPPPTMAEEEEGTTGELRSAEPAPADSRHPLTYRKTTNFALDKFLDPARPYKCTVCKESFTQKNILLVHYNSVSHLHKMKKAAIDPSAPARGEAGAPPTTTAATDKPFKCTVCRVSYNQSSTLEIHMRSVLHQTRSRGTKTDSKIEGPERSQEEPKEGETEGEVGTEKKGPDTSGFISGLPFLSPPPPPLDLHRFPAPLFTPPVLPPFPLVPESLLKLQQQQLLLPFYLHDLKVGPKLTLAGPAPVLSLPAATPPPPPQPPKAELAEREWERPPMAKEGNEAGPSSPPDPLPNEAARTAAKALLENFGFELVIQYNEGKQAVPPPPTPPPPEALGGGDKLACGACGKLFSNMLILKTHEEHVHRRFLPFEALSRYAAQFRKSYDSLYPPLAEPPKPPDGSLDSPVPHLGPPFLVPEPEAGGTRAPEERSRAGGHWPIEEEESSRGNLPPLVPAGRRFSRTKFTEFQTQALQSFFETSAYPKDGEVERLASLLGLASRVVVVWFQNARQKARKNACEGGSMPTGGGTGGASGCRRCHATFSCVFELVRHLKKCYDDQTLEEEEEEAERGEEEEEVEEEEVEEEQGLEPPAGPEGPLPEPPDGEELSQAEATKAGGKEPEEKATPSPSPAHTCDQCAISFSSQDLLTSHRRLHFLPSLQPSAPPQLLDLPLLVFGERNPLVAATSPMPGPPLKRKHEDGSLSPTGSEAGGGGEGEPPRDKRLRTTILPEQLEILYRWYMQDSNPTRKMLDCISEEVGLKKRVVQVWFQNTRARERKGQFRSTPGGVPSPAVKPPATATPASLPKFNLLLGKVDDGTGREAPKREAPAFPYPTATLASGPQPFLPPGKEATTPTPEPPLPLLPPPPPSEEEGPEEPPKASPESEACSLSAGDLSDSSASSLAEPESPGAGGTSGGPGGGTGVPDGMGQRRYRTQMSSLQLKIMKACYEAYRTPTMQECEVLGEEIGLPKRVIQVWFQNARAKEKKAKLQGTAAGSTGGSSEGLLAAQRTDCPYCDVKYDFYVSCRGHLFSRQHLAKLKEAVRAQLKSESKCYDLAPAPEAPPALKAPPATTPASMPLGAAPTLPRLAPVLLSGPALAQPPLGNLAPFNSGPAASSGLLGLATSVLPTTTVVQTAGPGRPLPQRPMPDQTNTSTAGTTDPVPGPPTEPLGDKVSSERKPVAGPTSSSNDALKNLKALKTTVPALLGGQFLPFPLPPAGGTAPPAVFGPQLQGAYFQQLYGMKKGLFPMNPMIPQTLIGLLPNALLQPPPQPPEPTATAPPKPPELPAPGEGEAGEVDELLTGSTGISTVDVTHRYLCRQCKMAFDGEAPATAHQRSFCFFGRGSGGSMPPPLRVPICTYHCLACEVLLSGREALASHLRSSAHRRKAAPPQGGPPISITNAATAASAAVAFAKEEARLPHTDSNPKTTTTSTLLAL", "length": 2572 }, "evidence": [ { "id": "E1BD77", "url": "https://omabrowser.org/oma/group/E1BD77/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BD77", "url": "https://www.uniprot.org/uniprotkb/E1BD77" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BD77", "url": "https://www.uniprot.org/uniprotkb/E1BD77" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BD77", "url": "https://www.uniprot.org/uniprotkb/E1BD77" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BD77", "url": "https://www.uniprot.org/uniprotkb/E1BD77" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BD77", "url": "https://www.uniprot.org/uniprotkb/E1BD77" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BD77", "url": "https://www.uniprot.org/uniprotkb/E1BD77" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BD77", "url": "https://www.uniprot.org/uniprotkb/E1BD77" } ], "pmid": "" }, { "name": "regulation of sensory perception of pain", "id": "GO:0051930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051930", "evidence": [ { "database": "UniProtKB", "id": "E1BD77", "url": "https://www.uniprot.org/uniprotkb/E1BD77" } ], "pmid": "" }, { "name": "regulation of neuron differentiation", "id": "GO:0045664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045664", "evidence": [ { "database": "UniProtKB", "id": "E1BD77", "url": "https://www.uniprot.org/uniprotkb/E1BD77" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1260, "end_pos": 1262, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1655, "end_pos": 1657, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2320, "end_pos": 2322, "annotation": "n_glycosylation_sequon" }, { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" }, { "start_pos": 392, "end_pos": 394, "annotation": "n_glycosylation_sequon" }, { "start_pos": 516, "end_pos": 518, "annotation": "n_glycosylation_sequon" }, { "start_pos": 524, "end_pos": 526, "annotation": "n_glycosylation_sequon" }, { "start_pos": 581, "end_pos": 583, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 968, "end_pos": 970, "annotation": "n_glycosylation_sequon" }, { "start_pos": 978, "end_pos": 980, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BD77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD77" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 455, "end_pos": 483, "start_aa": "Leu", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BD77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD77" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 1595, "end_pos": 1655, "start_aa": "Ala", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 32, 360, 629, 803, 949, 1469, 1971, 2356 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1260, "end_pos": 1262 }, { "start_pos": 1655, "end_pos": 1657 }, { "start_pos": 2320, "end_pos": 2322 }, { "start_pos": 308, "end_pos": 310 }, { "start_pos": 392, "end_pos": 394 }, { "start_pos": 516, "end_pos": 518 }, { "start_pos": 524, "end_pos": 526 }, { "start_pos": 581, "end_pos": 583 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 968, "end_pos": 970 }, { "start_pos": 978, "end_pos": 980 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 8 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 8 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 8 }, { "field": "exact_o_linked_sites", "count": 8 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", 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"Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1299308", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1299308", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5576886", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5576886", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179654", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T6V0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6V0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6V0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6V0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9M4", "url": "https://www.uniprot.org/uniprotkb/E1B9M4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9M4-1", "url": "https://www.uniprot.org/uniprotkb/E1B9M4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGALRPWARYGLLAVAHLLALGLGATVLQALEGPPALRLQANLRAELATFQAEFGACLPAGALEELLGTALVAQAHGVSSLGNGSEARNWDLPSALLFTASLLTTTGYGHMAPLSAGGKAFCVAYAALGLPASLALVAALRHCLVPLLSRPGAWVATCWQLTPPRAALLQAVALGLLVVGVFVLLPALVLWDVQGNCSLLEAIYFCFSSLSTIGLGDLLPGHGSGLHPVLYHLCQFALLGYLLLGLLAMLLTVETFSELPQVRAMVKFFGSSGPVNAEDEGAILGQDELALSNMPPSAAAPAQAPAC", "length": 307, "header": "tr|E1B9M4-1|E1B9M4_BOVIN Isoform 1 of Potassium channel subfamily K member OS=Bos taurus OX=9913 GN=KCNK7 PE=3 SV=1 CANONICAL=E1B9M4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T6V0-1", "url": "https://www.uniprot.org/uniprotkb/E1B9M4/entry#A0AAA9T6V0-1", "sequence": { "sequence": "MGALRPWARYGLLAVAHLLALGLGATVLQALEGPPALRLQANLRAELATFQAEFGACLPAGALEELLGTALVAQAHGVSSLGNGSEARNWDLPSALLFTASLLTTTGYGHMAPLSAGGKAFCVAYAALGLPASLALVAALRHCLVPLLSRPGAWVATCWQLTPPRAALLQAVALGLLVVGVFVLLPALVLWDVQGNCSLLEAIYFCFSSLSTIGLGDLLPGHGSGLHPVLYHLCQFALLGESSCGGWGRGGKKTLDY", "length": 257, "header": "tr|A0AAA9T6V0-1|E1B9M4_BOVIN Computationally mapped isoform of Potassium channel subfamily K member OS=Bos taurus OX=9913 GN=KCNK7 PE=3 SV=1 CANONICAL=E1B9M4-1" }, "locus": { "chromosome": "29", "start_pos": 43777094, "end_pos": 43774835, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112125.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112125.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093628.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093628.1" } ] } }, { "isoform_ac": "E1B9M4-1", "url": "https://www.uniprot.org/uniprotkb/E1B9M4/entry#E1B9M4-1", "sequence": { "sequence": "MGALRPWARYGLLAVAHLLALGLGATVLQALEGPPALRLQANLRAELATFQAEFGACLPAGALEELLGTALVAQAHGVSSLGNGSEARNWDLPSALLFTASLLTTTGYGHMAPLSAGGKAFCVAYAALGLPASLALVAALRHCLVPLLSRPGAWVATCWQLTPPRAALLQAVALGLLVVGVFVLLPALVLWDVQGNCSLLEAIYFCFSSLSTIGLGDLLPGHGSGLHPVLYHLCQFALLGYLLLGLLAMLLTVETFSELPQVRAMVKFFGSSGPVNAEDEGAILGQDELALSNMPPSAAAPAQAPAC", "length": 307, "header": "tr|E1B9M4-1|E1B9M4_BOVIN Isoform 1 of Potassium channel subfamily K member OS=Bos taurus OX=9913 GN=KCNK7 PE=3 SV=1 CANONICAL=E1B9M4-1" }, "locus": { "chromosome": "29", "start_pos": 43777094, "end_pos": 43774475, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014309.5", "url": "https://www.ensembl.org/id/ENSBTAT00000014309.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014309.4", "url": "https://www.ensembl.org/id/ENSBTAP00000014309.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 83, "start_aa": "Asn", "end_pos": 83, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn83", "evidence": [ { "id": "E1B9M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9M4#ptm_processing" }, { "id": "PIRSR038061-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038061-1" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:532497", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532497", "resource": "KEGG Pathway" }, { "id": "R-BTA-1299308", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1299308", "resource": "Reactome", "description": "Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)" }, { "id": "R-BTA-5576886", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5576886", "resource": "Reactome", "description": "Phase 4 - resting membrane potential" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A806-1", "protein_name": "Potassium channel subfamily K member 7", "gene_name": "Kcnk7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGTLKPWARYLLLVMAHLLAMGLGAVVLQALEGPPALHLQVQLQAELAAFQAEHRACLPPEALEELLGAVLTAQAHGVSSLGNGSETSNWDLPSALLFTASILTTTGYGRMAPFSSGGKAFCVVYAALGLPASLALVAALRRCLLPVFSCPGAWVAARWQLAPAQAALLQAAGLGLLVACVFMLLPALVLWGIQGDCSLLEAIYFCFGSLSTIGLGDLLPAQGRGLHPAIYRLGQFALLAVETFSELPQVRAVVKFFGPSSSRPDEDRDGILGQDELALSTMPPDAPVKGQTIPASASQQTPAC", "length": 304 }, "evidence": [ { "id": "E1B9M4", "url": "https://omabrowser.org/oma/group/E1B9M4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RRI8-1", "protein_name": "Potassium channel subfamily K member", "gene_name": "KCNK7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGALRPWARYGLLVVGHLLALGLGAAVLQALEGPPALRLQANLRAELATFQAEYGVCLPPGALEELLGAALAAQAHGVSSLGNGSEARNWDLPSALLFTASLLTTTGYGHMAPLSAGGKAFCVLYTALGLPASLALVAALRRCLLPLLSRQGAWVAMHWQLTPARAALLQAAGLGLLVAGTFVLLPALVLWSLQGDCSLLEAIYFCFGSLSTIGLGDLLPGRGRGLHPVLYHLGQFALLGYLLLGLLAMLLAVETFSELPQVRAMVKFFGSSDPLNAEDKGGILGQDELALSTLPPPEAAAGQAPAC", "length": 307 }, "evidence": [ { "id": "E1B9M4", "url": "https://omabrowser.org/oma/group/E1B9M4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9Y2U2-1", "protein_name": "Potassium channel subfamily K member 7", "gene_name": "KCNK7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGGLRPWSRYGLLVVAHLLALGLGAVVFQALEGPPACRLQAELRAELAAFQAEHRACLPPGALEELLGTALATQAHGVSTLGNSSEGRTWDLPSALLFAASILTTTGYGHMAPLSPGGKAFCMVYAALGLPASLALVATLRHCLLPVLSRPRAWVAVHWQLSPARAALLQAVALGLLVASSFVLLPALVLWGLQGDCSLLGAVYFCFSSLSTIGLEDLLPGRGRSLHPVIYHLGQLALLGYLLLGLLAMLLAVETFSELPQVRAMGKFFRPSGPVTAEDQGGILGQDELALSTLPPAAPASGQAPAC", "length": 307 }, "evidence": [ { "id": "E1B9M4", "url": "https://omabrowser.org/oma/group/E1B9M4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z2T1-1", "protein_name": "Potassium channel subfamily K member 7", "gene_name": "Kcnk7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSLKPWARYLLLLMAHLLAMGLGAVVLQALEGPPARHLQAQVQAELASFQAEHRACLPPEALEELLGAVLRAQAHGVSSLGNSSETSNWDLPSALLFTASILTTTGYGHMAPLSSGGKAFCVVYAALGLPASLALVAALRHCLLPVFSRPGDWVAIRWQLAPAQAALLQAAGLGLLVACVFMLLPALVLWGVQGDCSLLEAIYFCFGSLSTIGLGDLLPAHGRGLHPAIYHLGQFALLGYLLLGLLAMLLAVETFSELPQVRAMVKFFGPSGSRTDEDQDGILGQDELALSTVLPDAPVLGPTTPA", "length": 307 }, "evidence": [ { "id": "E1B9M4", "url": "https://omabrowser.org/oma/group/E1B9M4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "potassium channel activity", "id": "GO:0005267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005267", "evidence": [ { "database": "UniProtKB", "id": "E1B9M4", "url": "https://www.uniprot.org/uniprotkb/E1B9M4" } ], "pmid": "" }, { "name": "outward rectifier potassium channel activity", "id": "GO:0015271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015271", "evidence": [ { "database": "UniProtKB", "id": "E1B9M4", "url": "https://www.uniprot.org/uniprotkb/E1B9M4" } ], "pmid": "" }, { "name": "potassium ion leak channel activity", "id": "GO:0022841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022841", "evidence": [ { "database": "UniProtKB", "id": "E1B9M4", "url": "https://www.uniprot.org/uniprotkb/E1B9M4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "monoatomic ion channel complex", "id": "GO:0034702", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034702", "evidence": [ { "database": "UniProtKB", "id": "E1B9M4", "url": "https://www.uniprot.org/uniprotkb/E1B9M4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B9M4", "url": "https://www.uniprot.org/uniprotkb/E1B9M4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "potassium ion transmembrane transport", "id": "GO:0071805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "evidence": [ { "database": "UniProtKB", "id": "E1B9M4", "url": "https://www.uniprot.org/uniprotkb/E1B9M4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9M4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 307, "overlap": "1.0", 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BAL2-1", "uniprot_ac": "E1BAL2", "uniprot_id": "E1BAL2_BOVIN", "mass": { "chemical_mass": 25166.0, "monoisotopic_mass": 25166.0 }, "refseq": { "ac": "NP_001192621", "name": "protein Mis18-beta", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192621" }, "gene_names": [ { "name": "OIP5", "type": "recommended", "evidence": [ { "id": "E1BAL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL2" } ] }, { "name": "OIP5", "type": "synonym", "evidence": [ { "id": "NP_001192621", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192621" } ] } ], "protein_names": [ { "name": "Opa interacting protein 5", "type": "synonym", "evidence": [ { "id": "E1BAL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL2/entry#names_and_taxonomy" } ] }, { "name": "protein Mis18-beta", "type": "synonym", "evidence": [ { "id": "NP_001192621", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192621" } ] } ], "function": [ { "annotation": "Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6Y4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y4#function" }, { 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], "crossref": [ { "id": "E1BAL2", "url": "https://alphafold.ebi.ac.uk/entry/E1BAL2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010766", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010766", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511100", "url": "https://www.ncbi.nlm.nih.gov/gene/511100", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511100", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511100", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MDIHNVP", "url": "https://omabrowser.org/oma/group/MDIHNVP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAL2", "url": "https://www.orthodb.org/?gene=E1BAL2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16431", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16431", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16431:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16431:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-606279", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-606279", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192621", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T6Y4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6Y4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIB4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAL2", "url": "https://www.uniprot.org/uniprotkb/E1BAL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAL2-1", "url": "https://www.uniprot.org/uniprotkb/E1BAL2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAARPRRHISGIAKQPQGDFCDGAKKAIDEPSFATSMEWDTQVVKGSSPVGPAGLGLEKLPSRPRLPQWLQPERCAVFQCAQCHAVLADSVHLAWDLSRSLGAVVFSRVTNNVVLEAPFLVGIEGSLKGSTYNLLFCSFCEIPIGFHLYSTHAALAALRGHFCLSSDKMVCYLLKTKAIVNASEMDIHIIPLPEKVAELKEKIMLTHTRLNSLMKILKEMPPDQSKLTN", "length": 229, "header": "tr|E1BAL2-1|E1BAL2_BOVIN Isoform 1 of Opa interacting protein 5 OS=Bos taurus OX=9913 GN=OIP5 PE=4 SV=2 CANONICAL=E1BAL2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T6Y4-1", "url": "https://www.uniprot.org/uniprotkb/E1BAL2/entry#A0AAA9T6Y4-1", "sequence": { "sequence": "MAARPRRHISGIAKQPQGDFCDGAKKAIDEPSFATSMEWDTQVVKGSSPVGPAGLGLEKLPSRPRLPQWLQPERCAVFQCAQCHAVLADSVHLAWDLSRSLGAVVFSRVTNNVVLEAPFLVGIEGSLKGSTYNLLFCSFCEIPIGFHLYSTHAALAALRGHFCLSSDKMVWNFWKVRQNNAVVDTFPACAQPLFASHSGDLVAMSVSHVILLPGDGIRNRPDLC", "length": 224, "header": "tr|A0AAA9T6Y4-1|E1BAL2_BOVIN Computationally mapped isoform of Opa interacting protein 5 OS=Bos taurus OX=9913 GN=OIP5 PE=4 SV=1 CANONICAL=E1BAL2-1" }, "locus": { "chromosome": "10", "start_pos": 36789298, "end_pos": 36785815, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134279.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134279.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092356.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092356.1" } ] } }, { "isoform_ac": "A0AAA9TIB4-1", "url": "https://www.uniprot.org/uniprotkb/E1BAL2/entry#A0AAA9TIB4-1", "sequence": { "sequence": "MAARPRRHISGIAKQPQGDFCDGAKKAIDEPSFATSMEWDTQVVKGSSPVGPAGLGLEKLPSRPRLPQWLQPERCAVFQCAQCHAVLADSVHLAWDLSRSLGAVVFSRVTNNVVLEAPFLVGIEGSLKGSTYNLLFCSFCEIPIGFHLYSTHAALAALRGHFCLSSDKMVCYLLKTKAIVNASEMDIHIIPLPEKVAELFPLGNKGTHTFWESSRY", "length": 216, "header": "tr|A0AAA9TIB4-1|E1BAL2_BOVIN Computationally mapped isoform of Opa interacting protein 5 OS=Bos taurus OX=9913 GN=OIP5 PE=4 SV=1 CANONICAL=E1BAL2-1" }, "locus": { "chromosome": "10", "start_pos": 36789298, "end_pos": 36774718, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088284.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088284.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098038.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098038.1" } ] } }, { "isoform_ac": "E1BAL2-1", "url": "https://www.uniprot.org/uniprotkb/E1BAL2/entry#E1BAL2-1", "sequence": { "sequence": "MAARPRRHISGIAKQPQGDFCDGAKKAIDEPSFATSMEWDTQVVKGSSPVGPAGLGLEKLPSRPRLPQWLQPERCAVFQCAQCHAVLADSVHLAWDLSRSLGAVVFSRVTNNVVLEAPFLVGIEGSLKGSTYNLLFCSFCEIPIGFHLYSTHAALAALRGHFCLSSDKMVCYLLKTKAIVNASEMDIHIIPLPEKVAELKEKIMLTHTRLNSLMKILKEMPPDQSKLTN", "length": 229, "header": "tr|E1BAL2-1|E1BAL2_BOVIN Isoform 1 of Opa interacting protein 5 OS=Bos taurus OX=9913 GN=OIP5 PE=4 SV=2 CANONICAL=E1BAL2-1" }, "locus": { "chromosome": "10", "start_pos": 36789298, "end_pos": 36781287, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014256.4", "url": "https://www.ensembl.org/id/ENSBTAT00000014256.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014256.4", "url": "https://www.ensembl.org/id/ENSBTAP00000014256.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511100", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511100", "resource": "KEGG Pathway" }, { "id": "R-BTA-606279", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-606279", "resource": "Reactome", "description": "Deposition of new CENPA-containing nucleosomes at the centromere" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K615-1", "protein_name": "Opa interacting protein 5", "gene_name": "Oip5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATLSPRGLPVVETQSCSGSCDTPFSSSMEWDTQVVEGFSPLGSSGSEVKASPVDLRLPAWLKPERCAVFHCASCYAVLGDTVHLAWDLSKFLGALAFSRVTNNVVLLEPLLVGIEGSLKSSTYNLLFCNSCGTPVGFHLYSTRAALAALRGHFCLSCDKMLCYLLKTKAIVNTSEMDIYNVPLPEKIAELKEKIMLMHSRLNSLLRVLKEKTPPQSDQENRTSNKQGNNTILGFIE", "length": 237 }, "evidence": [ { "id": "E1BAL2", "url": "https://omabrowser.org/oma/group/E1BAL2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A4X1USP8-1", "protein_name": "Opa interacting protein 5", "gene_name": "OIP5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAARPRRHRSCYPRQSRRDFCDGPKKATDETSLTTSMEWDTQVVKGSSPLGPAGLGPEEPPAAPRLPWWLQPERCAVFQCAHCYAVLADSVHLAWDLSRSLGAVAFSRVTNNVVLEAPFLVGIEGSLKGSTYNLLFCSSCVIPIGFHLYSTHAALAALRGHFCLSSDKMVCYLLKTKAIVNASEMDIHNLPLPEKVAELKEKIMLMHTRLNSLMKILKKVTPDQSKPVD", "length": 229 }, "evidence": [ { "id": "E1BAL2", "url": "https://omabrowser.org/oma/group/E1BAL2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A2AQ14-1", "protein_name": "Protein Mis18-beta", "gene_name": "Oip5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATLSRRSLRFLETQSRRDSCDTPFSLTSSMEWDTQVVEGFSPLGSSESKVKASPVDLRLPAWLEPERCAVFHCARCYAVLGDTLHLAWDLSRSLGALAFSKVTNNVVLLEPFLVGIEGFLKSSTYNLLFCNSCGTPVGFHLYSTHAAMAALRGHFCLSSDKMLCYLLKTNAIVNTSEMDFHNVPLPEKIAELKEKIMLMHTRLNSLTGLLKGKSPHQFKQENQQARKQHILGLTASPKIL", "length": 241 }, "evidence": [ { "id": "E1BAL2", "url": "https://omabrowser.org/oma/group/E1BAL2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E1BQA1-1", "protein_name": "Opa interacting protein 5", "gene_name": "OIP5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAVRRQLQRFFEEPQVRGTIVVERPLSSEPPPAPPPTSEVPRCYELRPEDCAVFQCRGCWAVLGDSLHLCALEEQRLGLLVCLRVTSNVLCEEALMVGLEGALMGCAYNTLSCQSCGSVVGFVLYSAFRDLAHLRGFFCFFKNSIFCYLLKSKMIIEASKVKFPAVTLKDEMEKLKESLVMAHMRVELLMKKVEQLKQNNVAENRALHHMQLH", "length": 213 }, "evidence": [ { "id": "E1BAL2", "url": "https://omabrowser.org/oma/group/E1BAL2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O43482-1", "protein_name": "Protein Mis18-beta", "gene_name": "OIP5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAQPLRHRSRCATPPRGDFCGGTERAIDQASFTTSMEWDTQVVKGSSPLGPAGLGAEEPAAGPQLPSWLQPERCAVFQCAQCHAVLADSVHLAWDLSRSLGAVVFSRVTNNVVLEAPFLVGIEGSLKGSTYNLLFCGSCGIPVGFHLYSTHAALAALRGHFCLSSDKMVCYLLKTKAIVNASEMDIQNVPLSEKIAELKEKIVLTHNRLKSLMKILSEVTPDQSKPEN", "length": 229 }, "evidence": [ { "id": "E1BAL2", "url": "https://omabrowser.org/oma/group/E1BAL2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BAL2", "url": "https://www.uniprot.org/uniprotkb/E1BAL2" } ], "pmid": "" }, { "name": "chromosome, centromeric region", "id": "GO:0000775", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000775", "evidence": [ { "database": "UniProtKB", "id": "E1BAL2", "url": "https://www.uniprot.org/uniprotkb/E1BAL2" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "E1BAL2", "url": "https://www.uniprot.org/uniprotkb/E1BAL2" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "E1BAL2", "url": "https://www.uniprot.org/uniprotkb/E1BAL2" } ], "pmid": "" }, { "name": "Cajal body", "id": "GO:0015030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015030", "evidence": [ { "database": "UniProtKB", "id": "E1BAL2", "url": "https://www.uniprot.org/uniprotkb/E1BAL2" } ], "pmid": "" }, { "name": "chromocenter", "id": "GO:0010369", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010369", "evidence": [ { "database": "UniProtKB", "id": "E1BAL2", "url": "https://www.uniprot.org/uniprotkb/E1BAL2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BAL2", "url": "https://www.uniprot.org/uniprotkb/E1BAL2" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BAL2", "url": "https://www.uniprot.org/uniprotkb/E1BAL2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "E1BAL2", "url": "https://www.uniprot.org/uniprotkb/E1BAL2" } ], "pmid": "" }, { "name": "CENP-A containing chromatin assembly", "id": "GO:0034080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034080", "evidence": [ { "database": "UniProtKB", "id": "E1BAL2", "url": "https://www.uniprot.org/uniprotkb/E1BAL2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 181, "end_pos": 183, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BAL2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 229, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BAL2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BAL2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BAL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL2" }, { "id": "PS51793", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51793" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Mis18", "eco_id": "ECO_0000259", "start_pos": 75, "end_pos": 174, "start_aa": "Cys", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 181, "end_pos": 183 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B8F2-1", "uniprot_ac": "E1B8F2", "uniprot_id": "E1B8F2_BOVIN", "mass": { "chemical_mass": 55361.0, "monoisotopic_mass": 55361.0 }, "refseq": { "ac": "NP_001192744", "name": "forkhead box protein N4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192744" }, "gene_names": [ { "name": "FOXN4", "type": "recommended", "evidence": [ { "id": "E1B8F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8F2" } ] }, { "name": "FOXN4", "type": "synonym", "evidence": [ { "id": "NP_001192744", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192744" } ] } ], "protein_names": [ { "name": "Forkhead box N4", "type": "synonym", "evidence": [ { "id": "E1B8F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8F2/entry#names_and_taxonomy" } ] }, { "name": "forkhead box protein N4", "type": "synonym", "evidence": [ { "id": "NP_001192744", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192744" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8F2", "url": "https://www.uniprot.org/uniprotkb/E1B8F2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FOXN4", "url": "https://www.uniprot.org/uniprotkb/E1B8F2", "locus": { "chromosome": "17", "start_pos": 63842782, "end_pos": 63817761, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010847", "url": "https://www.ensembl.org/id/ENSBTAG00000010847" } ] } } ], "crossref": [ { "id": "E1B8F2", "url": "https://alphafold.ebi.ac.uk/entry/E1B8F2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010847", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010847", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20057", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20057", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515612", "url": "https://www.ncbi.nlm.nih.gov/gene/515612", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030456", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030456", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047119", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047119", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515612", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515612", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QCPTSVY", "url": "https://omabrowser.org/oma/group/QCPTSVY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8F2", "url": "https://www.orthodb.org/?gene=E1B8F2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13962", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13962", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13962:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13962:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00250", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00250", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192744", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T7X9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7X9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7X9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7X9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8F2", "url": "https://www.uniprot.org/uniprotkb/E1B8F2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8F2-1", "url": "https://www.uniprot.org/uniprotkb/E1B8F2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIESDISSMMSGIIRNSGQNHHPSPQEYRLLAATCDDNLPGDLQSLSWLTAVDVPRLQQMASGRVDLGGPSAPHTHPGALARAADLHVAATPGHLLQGPPGMAPQGVLGLSPLTNHGASQMNQFAVGGQPSSSLQNPPQLYSAASQPQFPLPSGVQQCAPVGLYGSTFGARPPYPQPRMAVHSSQELHPKHYPKPIYSYSCLIAMALKNSKTGSLPVSEIYSFMKEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVENKMSGSSRKGCLWALNLARIDKMEEEMHKWKRKDLAAIHRSMANPEELDKLISDRPESCRRPGKPGEPEAPALTHATTVAMAHSCLAVSQLPPQPLMTLSLQSVPLHHQVQPQAHLAPDSPAPAQTPPLHALPDLSPSPLPHPAMGRAPVDFINISTDMNTEVDALDPSIMDFALQGNLWEEIKDEGFSLDTLGAFGDSPLGCELGASGLTPVSGGSDQSFPDLQVTGLYAAYSTPDSVATSATTSSSQYLGAPGNKPIALL", "length": 518, "header": "tr|E1B8F2-1|E1B8F2_BOVIN Isoform 1 of Forkhead box N4 OS=Bos taurus OX=9913 GN=FOXN4 PE=4 SV=3 CANONICAL=E1B8F2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T7X9-1", "url": "https://www.uniprot.org/uniprotkb/E1B8F2/entry#A0AAA9T7X9-1", "sequence": { "sequence": "MIESDISSMMSGIIRNSGQNHHPSPQEYRLLAATCDDNLPGDLQSLSWLTAVDVPRLQQMASGRVDLGGPSAPHTHPGALARAADLHVAATPGHLLQGPPGMAPQGVLGLSPLTNHGASVSATMWVGEQGRCPTGLGSPSTLRLLLSRPQQMNQFAVGGQPSSSLQNPPQLYSAASQPQFPLPSGVQQCAPVGLYGSTFGARPPYPQPRMAVHSSQELHPKHYPKPIYSYSCLIAMALKNSKTGSLPVSEIYSFMKEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVENKMSGSSRKGCLWALNLARIDKMEEEMHKWKRKDLAAIHRSMANPEELDKLISDRPESCRRPGKPGEPEAPALTHATTVAMAHSCLAVSQLPPQPLMTLSLQSVPLHHQVQPQAHLAPDSPAPAQTPPLHALPDLSPSPLPHPAMGRAPVDFINISTDMNTEVDALDPSIMDFALQGNLWEEIKDEGFSLDTLGAFGDSPLGCELGASGLTPVSGGSDQSFPDLQVTGLYAAYSTPDSVATSATTSSSQYLGAPGNKPIALL", "length": 549, "header": "tr|A0AAA9T7X9-1|E1B8F2_BOVIN Computationally mapped isoform of Forkhead box N4 OS=Bos taurus OX=9913 GN=FOXN4 PE=4 SV=1 CANONICAL=E1B8F2-1" }, "locus": { "chromosome": "17", "start_pos": 63841778, "end_pos": 63818770, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089052.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089052.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092714.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092714.1" } ] } }, { "isoform_ac": "E1B8F2-1", "url": "https://www.uniprot.org/uniprotkb/E1B8F2/entry#E1B8F2-1", "sequence": { "sequence": "MIESDISSMMSGIIRNSGQNHHPSPQEYRLLAATCDDNLPGDLQSLSWLTAVDVPRLQQMASGRVDLGGPSAPHTHPGALARAADLHVAATPGHLLQGPPGMAPQGVLGLSPLTNHGASQMNQFAVGGQPSSSLQNPPQLYSAASQPQFPLPSGVQQCAPVGLYGSTFGARPPYPQPRMAVHSSQELHPKHYPKPIYSYSCLIAMALKNSKTGSLPVSEIYSFMKEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVENKMSGSSRKGCLWALNLARIDKMEEEMHKWKRKDLAAIHRSMANPEELDKLISDRPESCRRPGKPGEPEAPALTHATTVAMAHSCLAVSQLPPQPLMTLSLQSVPLHHQVQPQAHLAPDSPAPAQTPPLHALPDLSPSPLPHPAMGRAPVDFINISTDMNTEVDALDPSIMDFALQGNLWEEIKDEGFSLDTLGAFGDSPLGCELGASGLTPVSGGSDQSFPDLQVTGLYAAYSTPDSVATSATTSSSQYLGAPGNKPIALL", "length": 518, "header": "tr|E1B8F2-1|E1B8F2_BOVIN Isoform 1 of Forkhead box N4 OS=Bos taurus OX=9913 GN=FOXN4 PE=4 SV=3 CANONICAL=E1B8F2-1" }, "locus": { "chromosome": "17", "start_pos": 63841778, "end_pos": 63818770, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014397.5", "url": "https://www.ensembl.org/id/ENSBTAT00000014397.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014397.4", "url": "https://www.ensembl.org/id/ENSBTAP00000014397.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 91, "start_aa": "Thr", "end_pos": 91, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr91", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:515612", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515612", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061I216-1", "protein_name": "Forkhead box protein N4", "gene_name": "Foxn4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MIQSDILPKMSGMIRSSGLSHHRSPQEYRLLPTMGDDDLPGDLQSLSWLTSVDVPRLQQMASGRIDLGSPSMPHPHPGSLAGAADLNVGATSHPLLRGQAAMAPRGMLGLGPRASAEQMNSFPIGGQSASPSGLQEVPQLYSPATPLQYPLPPGPQQCPPAGLYGSPFAARPSYPQAHMAVRSPQDLHPKHYPKPIYSYSCLIAMALKSSKTGSLPVSEIYSFMKEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVETKSSGSSRKGCLWALNLARIDKMEEEMHKWKRKDLAAIHRSMANPEELDKLISDRPESCRRPGKPGEPEAPMLTHATTVAMAHSCLGISQLPPKPLMTLSLQSVPLHHQVQPQTHLAPDSPAPAQTPPLHALPNLSPGPLPQPVMGRPPGDFLNISTDMNTEVDALDPSIMDFALQGNLWEEVKEDSFSLETLGAFGDSPLGCDLGAPSLTPVSGSGDQSFPDVQVTGLYAAYSTPDSMAPAVATSAQYLGTPGNKPIALL", "length": 517 }, "evidence": [ { "id": "E1B8F2", "url": "https://omabrowser.org/oma/group/E1B8F2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8I6AB90-1", "protein_name": "Forkhead box N4", "gene_name": "Foxn4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLRVGQLQRGKFKNGSSCDGRPNSRQQGASAREYPCRSAARPSPTQDPLQEMIESDIQSKMSGMIRSSGHSHHRSPQEYRFLPPAGDDDLPGDLQSLSWLTAVDVPRLQQMASGRIDLGSPSVPHPHPGAMAGVADPHVGAAPRPMLRSQTAMVPRGMLGLSPIGSYRASAEQMNQFPVGGQSSSGLQEMPQLYSPATQIQFPLPSGSQQCPPTSLYGSPFAARPPYPQAHVTVHSPQEAHPKHYPKPIYSYSCLIAMALKSSKTGSLPVSEIYSFMKEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVETKPSGSSRKGCLWALNLARIDKVEEEMHKWKRKDLAAIHRSMANPEELDKLISDRPESCRRPGKQGEPEVPVLTRATTVAMTHSCLAISQLPPKPLMTLSLQSVPLHHQVQPQAHLAPDSPAPAQTPPLHALPNLSPGPLPQPAVGRVPGDFLNISTDTNTEVDALDPSIMDFALQGNLWEEMREESFSLDTLGAFGDSPLGCDLGTPSLTPVSGSGDQPFPDVQVTGLYAAYSTVTADSVAPSVVNSAQYLGTPGNKPIALL", "length": 572 }, "evidence": [ { "id": "E1B8F2", "url": "https://omabrowser.org/oma/group/E1B8F2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A2BGM5-1", "protein_name": "Forkhead box protein N4", "gene_name": "foxn4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTVQSKLQGRGKFKKRFFRAGQQVPRPTLELSSVWLSKIFYNPEQHHNKQKMIESGITTRMSGIHENPGQSHHTSAQDYRLLTTDPSQLKDELPGDLQSLSWLTSVDVPRLQQIGGGRPDFTSSAQSSLLERQTAQLNSMTVAGGAGSAIHLQSEMQHSPLAINSMPQFSPGFPCAASVYQTAPQQVLTFTQANQQCSPGGLYGNYNSQNLFPQPRITAHSQDLQPKCFPKPIYSYSCLIAMALKNSKTGSLPVSEIYSFMKEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVENKMSGSSRKGCLWALNPAKIDKMEEEMQKWKRKDLPAIRRSMANPDELDKLITDRPESCRQKSVDPGMTRLPSCPPGQTLPLAAQMQPQPVVTLSLQCLPMHQHLQLQLQNQSRLAPSSPAPAQTPPLHTVPDMTNSSLPQHPAKQHTDFYTVHTDVNSEVDALDPSIMDFAWQGNLWEEMKDDSFNLEALGTLSNSPLRLSDCDLDTSSVTPVSSAGGLPYPDLQVTGLYSSYSAIDALSNQYMNTQGGTKPIVLL", "length": 550 }, "evidence": [ { "id": "E1B8F2", "url": "https://omabrowser.org/oma/group/E1B8F2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8K3Q3-1", "protein_name": "Forkhead box protein N4", "gene_name": "Foxn4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIESGIWSRMSEMIRSSGHSHHCSPQEYRFLPPVGDDDLPGDLQSLSWLTAVDVPRLQQMANGRIDLGSSGVTHPHPGALAGTADLHVGAAPRPLLRRSQTAVVPRGVLGLSPIGNHRASAEQMNQFPAGGQASSGLQEMPQLYSPATQIPFPLPLGSQQCPPAGLYGSPFSARPSYPQAHGAMHASQEPHPKHYPKPIYSYSCLIAMALKNSKTGSLPVSEIYSFMKEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVETKSSGSSRKGCLWALNLARIDKMEEEMHKWKRKDLAAIHRSMANPEELDKLISDRPESCRRPGKRGEPKAPMLTHATTVAMAHSCLAISQLPPKPLMTLSLQSVPLHHQLQPQAHLAPDSPAPAQTPPLHALPSLSPGPLPQPAMGRVPGDFLNINSDMNTEVDALDPSIMDFALQGNLWEEMKEDSFSLDTLEAFGDSPLGCDLGAPSLTPVSGNSDQSFPDVQVTGLYAAYSTAADGVAPSAANSAQYLGTPGNKPIALL", "length": 521 }, "evidence": [ { "id": "E1B8F2", "url": "https://omabrowser.org/oma/group/E1B8F2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96NZ1-1", "protein_name": "Forkhead box protein N4", "gene_name": "FOXN4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIESDTSSIMSGIIRNSGQNHHPSPQEYRLLATTSDDDLPGDLQSLSWLTAVDVPRLQQMASGRVDLGGPCVPHPHPGALAGVADLHVGATPSPLLHGPAGMAPRGMPGLGPITGHRDSMSQFPVGGQPSSGLQDPPHLYSPATQPQFPLPPGAQQCPPVGLYGPPFGVRPPYPQPHVAVHSSQELHPKHYPKPIYSYSCLIAMALKNSKTGSLPVSEIYSFMKEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVENKMSGSSRKGCLWALNLARIDKMEEEMHKWKRKDLAAIHRSMANPEELDKLISDRPESCRRPGKPGEPEAPVLTHATTVAVAHGCLAVSQLPPQPLMTLSLQSVPLHHQVQPQAHLAPDSPAPAQTPPLHALPDLSPSPLPHPAMGRAPVDFINISTDMNTEVDALDPSIMDFALQGNLWEEMKDEGFSLDTLGAFADSPLGCDLGASGLTPASGGSDQSFPDLQVTGLYTAYSTPDSVAASGTSSSSQYLGAQGNKPIALL", "length": 517 }, "evidence": [ { "id": "E1B8F2", "url": "https://omabrowser.org/oma/group/E1B8F2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "E1B8F2", "url": "https://www.uniprot.org/uniprotkb/E1B8F2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1B8F2", "url": "https://www.uniprot.org/uniprotkb/E1B8F2" } ], "pmid": "" }, { "name": "cis-regulatory region sequence-specific DNA binding", "id": "GO:0000987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000987", "evidence": [ { "database": "UniProtKB", "id": "E1B8F2", "url": "https://www.uniprot.org/uniprotkb/E1B8F2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "E1B8F2", "url": "https://www.uniprot.org/uniprotkb/E1B8F2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": 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"MGCTASIVLLQAFRSVVQRSCPHICRRRQEEPSHEILPLEIDDEMSRPRTLIIMQEKPRLLEPLDYETVIEELEKTYQNDPLRDLLFFPSDDFSTTTVSWDIRTLYSTVPEDAEHKAENLLVKEACKFYSSQWYVVNYKYEQYSGDIRQLPRAEYKPEKLPSHSFEVDHEDADKDEDTTSHSSSKGGGGTGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRFFQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGPPQGRRSAELTDLGLDSLDNAVTCESTPEEADSSENSLHPDFTKYLTETEETVKATRNMERLNLFSLDPDIDSLKLQKKDLLEPEFVIKPFEEKAAKRIMIICKALNLNLQGCVTENENDPTTNIEPFFVSVALYDLRDSRKISADFHVDLNHTAVRQMLLGASVAVENGNVDTVTPRQSGEPHIKGFPEEWLKFPKQAIFSVSNPHSEIVLVAKIEKVLMGNIASGAEPYIKNPDSNKYAQKILKSNRQFCSKLGKYRMPFAWAVRSVFKDNQGNVDRDSRFSPLYRQESNKISTEDLLKLVSDYRRADRISKTQTIPGSLDIAVDNIPLEHPNCVTSSFIPVKPFNVTAKPEPTVEVEEFIYDSTKYCRPYRVYKNQIYIYPKHLKYDSQKCFNKARNITVCVEFKNSDEEDARPLKCIYGKPGGPLFTSAAYTAVLHHSQNPDFSDEVKIELPTQLHEKHHILFSFHHVTCDINAKANAKKKEALETPVGYAWLPLMKDDQIASQEYNIPVATSLPPNYLSFQDSANGKHTGSDIKWVDGGKPLFKVSTFVVSTVNTQDPHVNAFFRQCQKREKDMSQSPTSNFVRSCKNLLNVEKIHAIMSFLPIILNQLFKILVQNEEDEISTTVTRVLTDIVAKCHEEQLDHSVQSYIKFVFKTTAYKERTIHEELVKNMTGLLQSNDSTTVKHVLKHSWFFFAIILKSMAQHLIDTNKIQLSRPQRFPESFQNELDNLVMSFADHMIWKNKDALEETKRANHSVARFLKRCFTFMDRGFVFKMVNNYISMFSSGDPKTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESIQELHASDMPEYSVTNEFCRKHFLIGILLREVGFALQEDQDIRHLALAVLKNLMAKHSFDDRYREPEKQAQIAGLYMPLYGMLLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFHTQSAMKHANSADTSFSKDVLNSIAAFSSIAISTVTHADSRASLASLDSNPSTTEKSSEKTDNCEKIPRPLSLIGSTLRFDKLDQAETRSLLMCFLHIMKTISEETLIAYWQRAPSPEVSDFFSILDVCLQNFRYLGKRNIIRKIAAAFKFVQSTQNNGTLKGSNPSCQTSGLLSQWMHTTSSHEGQKQHRSQTLPIIRGKNALSNPKLLQMLDNTMTSNSNEIDIVHHVDTEANIATEVCLTILDLLALFTQVHQRQLQQSECQNSMMKRVFDTYMLFFQVNQSATALKHVFASLRLFVCKFPSAFFQGPADLCGSFCYEVLKCCNHRSRSTQMEASALLYFFMRKNFEFNKQKSIVRSHLQLIKAVSQLIADAGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIAEYLKRRGYWKMEKICVPSLLLEDVHPCDSNPLLTTPSGGSMFSMGWPAFLSITPNIKEEGEMKEDSGMQDTPYNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFEKQRDFKKLSDLYYDIHRSYLKVAEVVNSEKRLFGRYYRVAFYGQGFFEEEEGKEYIYKEPKLTGLSEISQRLLKLYADKFGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDRKTDFEMHHNINRFVFETPFTLSGKKHGGVEEQCKRRTVLTTSHLFPYVKKRIQVVSQSSTELNPIEVAIDEMSKKVSELNQLCTMEEVDMIRLQLKLQGSVSVKVNAGPMAYARAFLEETNAKKYPDNQVKLLKEIFRQFADACGQALDVNERLIKEDQLEYQEELRSHYKDMLSELSAIMNEQITYRDDPSKRGVERTCSRVINKAAPSLPTVSVSPSGEV", "length": 2199, "header": "tr|E1B7C4-1|E1B7C4_BOVIN Isoform 1 of Dedicator of cytokinesis 10 OS=Bos taurus OX=9913 GN=DOCK10 PE=3 SV=3 CANONICAL=E1B7C4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TA28-1", "url": "https://www.uniprot.org/uniprotkb/E1B7C4/entry#A0AAA9TA28-1", "sequence": { "sequence": "MSFRGKVFKRDPSEFWKKRRTMRRKNQEEIHRFTSQEKPRLLEPLDYETVIEELEKTYQNDPLRDLLFFPSDDFSTTTVSWDIRTLYSTVPEDAEHKAENLLVKEACKFYSSQWYVVNYKYEQYSGDIRQLPRAEYKPEKLPSHSFEVDHEDADKDEDTTSHSSSKGGGGTGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRFFQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGPPQGRRSAELTDLGLDSLDNAVTCESTPEEADSSENSLHPDFTKYLTETEETVKATRNMERLNLFSLDPDIDSLKLQKKDLLEPEFVIKPFEEKAAKRIMIICKALNLNLQGCVTENENDPTTNIEPFFVSVALYDLRDSRKISADFHVDLNHTAVRQMLLGASVAVENGNVDTVTPRQSGEPHIKGFPEEWLKFPKQAIFSVSNPHSEIVLVAKIEKVLMGNIASGAEPYIKNPDSNKYAQKILKSNRQFCSKLGKYRMPFAWAVRSVFKDNQGNVDRDSRFSPLYRQESNKISTEDLLKLVSDYRRADRISKTQTIPGSLDIAVDNIPLEHPNCVTSSFIPVKPFNVTAKPEPTVEVEEFIYDSTKYCRPYRVYKNQIYIYPKHLKYDSQKCFNKARNITVCVEFKNSDEEDARPLKCIYGKPGGPLFTSAAYTAVLHHSQNPDFSDEVKIELPTQLHEKHHILFSFHHVTCDINAKANAKKKEALETPVGYAWLPLMKDDQIASQEYNIPVATSLPPNYLSFQDSANGKHTGSDIKWVDGGKPLFKVSTFVVSTVNTQDPHVNAFFRQCQKREKDMSQSPTSNFVRSCKNLLNVEKIHAIMSFLPIILNQLFKILVQNEEDEISTTVTRVLTDIVAKCHEEQLDHSVQSYIKFVFKTTAYKERTIHEELVKNMTGLLQSNDSTTVKHVLKHSWFFFAIILKSMAQHLIDTNKIQLSRPQRFPESFQNELDNLVMSFADHMIWKNKDALEETKRANHSVARFLKRCFTFMDRGFVFKMVNNYISMFSSGDPKTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESIQELHASDMPEYSVTNEFCRKHFLIGILLREVGFALQEDQDIRHLALAVLKNLMAKHSFDDRYREPEKQAQIAGLYMPLYGMLLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFHTQSAMKHANSADTSFSKDVLNSIAAFSSIAISTVTHADSRASLASLDSNPSTTEKSSEKTDNCEKIPRPLSLIGSTLRFDKLDQAETRSLLMCFLHIMKTISEETLIAYWQRAPSPEVSDFFSILDVCLQNFRYLGKRNIIRKIAAAFKFVQSTQNNGTLKGSNPSCQTSGLLSQWMHTTSSHEGQKQHRSQTLPIIRGKNALSNPKLLQMLDNTMTSNSNEIDIVHHVDTEANIATEVCLTILDLLALFTQVHQRQLQQSECQNSMMKRVFDTYMLFFQVNQSATALKHVFASLRLFVCKFPSAFFQGPADLCGSFCYEVLKCCNHRSRSTQMEASALLYFFMRKNFEFNKQKSIVRSHLQLIKAVSQLIADAGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIAEYLKRRGYWKMEKICVPSLLLEDVHPCDSNPLLTTPSGGSMFSMGWPAFLSITPNIKEEGEMKEDSGMQDTPYNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFEKQRDFKKLSDLYYDIHRSYLKVAEVVNSEKRLFGRYYRVAFYGQGFFEEEEGKEYIYKEPKLTGLSEISQRLLKLYADKFGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDRKTDFEMHHNINRFVFETPFTLSGKKHGGVEEQCKRRTVLTTSHLFPYVKKRIQVVSQSSTELNPIEVAIDEMSKKVSELNQLCTMEEVDMIRLQLKLQGSVSVKVNAGPMAYARAFLEETNAKKYPDNQVKLLKEIFRQFADACGQALDVNERLIKEDQLEYQEELRSHYKDMLSELSAIMNEQLCRGPCLYSFCSSVSSISLSTVSKSDYLPGRPIKARSGANLQSSN", "length": 2187, "header": "tr|A0AAA9TA28-1|E1B7C4_BOVIN Computationally mapped isoform of Dedicator of cytokinesis 10 OS=Bos taurus OX=9913 GN=DOCK10 PE=3 SV=1 CANONICAL=E1B7C4-1" }, "locus": { "chromosome": "2", "start_pos": 113056863, "end_pos": 112862654, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111880.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111880.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093730.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093730.1" } ] } }, { "isoform_ac": "A0AAA9TUF3-1", "url": "https://www.uniprot.org/uniprotkb/E1B7C4/entry#A0AAA9TUF3-1", "sequence": { "sequence": "MAGERTRRFTRSLLRPGQAAELRHSAASAAAVAVSSRQQQRQEKPRLLEPLDYETVIEELEKTYQNDPLRDLLFFPSDDFSTTTVSWDIRTLYSTVPEDAEHKAENLLVKEACKFYSSQWYVVNYKYEQYSGDIRQLPRAEYKPEKLPSHSFEVDHEDADKDEDTTSHSSSKGGGGTGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRFFQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGPPQGRRSAELTDLGLDSLDNAVTCESTPEEADSSENSLHPDFTKYLTETEETVKATRNMERLNLFSLDPDIDSLKLQKKDLLEPEFVIKPFEEKAAKRIMIICKALNLNLQGCVTENENDPTTNIEPFFVSVALYDLRDSRKISADFHVDLNHTAVRQMLLGASVAVENGNVDTVTPRQSGEPHIKGFPEEWLKFPKQAIFSVSNPHSEIVLVAKIEKVLMGNIASGAEPYIKNPDSNKYAQKILKSNRQFCSKLGKYRMPFAWAVRSVFKDNQGNVDRDSRFSPLYRQESNKISTEDLLKLVSDYRRADRISKTQTIPGSLDIAVDNIPLEHPNCVTSSFIPVKPFNVTAKPEPTVEVEEFIYDSTKYCRPYRVYKNQIYIYPKHLKYDSQKCFNKARNITVCVEFKNSDEEDARPLKCIYGKPGGPLFTSAAYTAVLHHSQNPDFSDEVKIELPTQLHEKHHILFSFHHVTCDINAKANAKKKEALETPVGYAWLPLMKDDQIASQEYNIPVATSLPPNYLSFQDSANGKHTGSDIKWVDGGKPLFKVSTFVVSTVNTQDPHVNAFFRQCQKREKDMSQSPTSNFVRSCKNLLNVEKIHAIMSFLPIILNQLFKILVQNEEDEISTTVTRVLTDIVAKCHEEQLDHSVQSYIKFVFKTTAYKERTIHEELVKNMTGLLQSNDSTTVKHVLKHSWFFFAIILKSMAQHLIDTNKIQLSRPQRFPESFQNELDNLVMSFADHMIWKNKDALEETKRANHSVARFLKRCFTFMDRGFVFKMVNNYISMFSSGDPKTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESIQELHASDMPEYSVTNEFCRKHFLIGILLREVGFALQEDQDIRHLALAVLKNLMAKHSFDDRYREPEKQAQIAGLYMPLYGMLLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFHTQSAMKHANSADTSFSKDVLNSIAAFSSIAISTVTHADSRASLASLDSNPSTTEKSSEKTDNCEKIPRPLSLIGSTLRFDKLDQAETRSLLMCFLHIMKTISEETLIAYWQRAPSPEVSDFFSILDVCLQNFRYLGKRNIIRKIAAAFKFVQSTQNNGTLKGSNPSCQTSGLLSQWMHTTSSHEGQKQHRSQTLPIIRGKNALSNPKLLQMLDNTMTSNSNEIDIVHHVDTEANIATEVCLTILDLLALFTQVHQRQLQQSECQNSMMKRVFDTYMLFFQVNQSATALKHVFASLRLFVCKFPSAFFQGPADLCGSFCYEVLKCCNHRSRSTQMEASALLYFFMRKNFEFNKQKSIVRSHLQLIKAVSQLIADAGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIAEYLKRRGYWKMEKICVPSLLLEDVHPCDSNPLLTTPSGGSMFSMGWPAFLSITPNIKEEGEMKEDSGMQDTPYNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFEKQRDFKKLSDLYYDIHRSYLKVAEVVNSEKRLFGRYYRVAFYGQGFFEEEEGKEYIYKEPKLTGLSEISQRLLKLYADKFGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDRKTDFEMHHNINRFVFETPFTLSGKKHGGVEEQCKRRTVLTTSHLFPYVKKRIQVVSQSSTELNPIEVAIDEMSKKVSELNQLCTMEEVDMIRLQLKLQGSVSVKVNAGPMAYARAFLEETNAKKYPDNQVKLLKEIFRQFADACGQALDVNERLIKEDQLEYQEELRSHYKDMLSELSAIMNEQITYRDDPSKRGVERTCSRVINKAAPSLPTVSVSPSGEV", "length": 2186, "header": "tr|A0AAA9TUF3-1|E1B7C4_BOVIN Computationally mapped isoform of Dedicator of cytokinesis 10 OS=Bos taurus OX=9913 GN=DOCK10 PE=3 SV=1 CANONICAL=E1B7C4-1" }, "locus": { "chromosome": "2", "start_pos": 113166767, "end_pos": 112862599, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088898.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088898.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100193.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100193.1" } ] } }, { "isoform_ac": "E1B7C4-1", "url": "https://www.uniprot.org/uniprotkb/E1B7C4/entry#E1B7C4-1", "sequence": { "sequence": "MGCTASIVLLQAFRSVVQRSCPHICRRRQEEPSHEILPLEIDDEMSRPRTLIIMQEKPRLLEPLDYETVIEELEKTYQNDPLRDLLFFPSDDFSTTTVSWDIRTLYSTVPEDAEHKAENLLVKEACKFYSSQWYVVNYKYEQYSGDIRQLPRAEYKPEKLPSHSFEVDHEDADKDEDTTSHSSSKGGGGTGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRFFQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGPPQGRRSAELTDLGLDSLDNAVTCESTPEEADSSENSLHPDFTKYLTETEETVKATRNMERLNLFSLDPDIDSLKLQKKDLLEPEFVIKPFEEKAAKRIMIICKALNLNLQGCVTENENDPTTNIEPFFVSVALYDLRDSRKISADFHVDLNHTAVRQMLLGASVAVENGNVDTVTPRQSGEPHIKGFPEEWLKFPKQAIFSVSNPHSEIVLVAKIEKVLMGNIASGAEPYIKNPDSNKYAQKILKSNRQFCSKLGKYRMPFAWAVRSVFKDNQGNVDRDSRFSPLYRQESNKISTEDLLKLVSDYRRADRISKTQTIPGSLDIAVDNIPLEHPNCVTSSFIPVKPFNVTAKPEPTVEVEEFIYDSTKYCRPYRVYKNQIYIYPKHLKYDSQKCFNKARNITVCVEFKNSDEEDARPLKCIYGKPGGPLFTSAAYTAVLHHSQNPDFSDEVKIELPTQLHEKHHILFSFHHVTCDINAKANAKKKEALETPVGYAWLPLMKDDQIASQEYNIPVATSLPPNYLSFQDSANGKHTGSDIKWVDGGKPLFKVSTFVVSTVNTQDPHVNAFFRQCQKREKDMSQSPTSNFVRSCKNLLNVEKIHAIMSFLPIILNQLFKILVQNEEDEISTTVTRVLTDIVAKCHEEQLDHSVQSYIKFVFKTTAYKERTIHEELVKNMTGLLQSNDSTTVKHVLKHSWFFFAIILKSMAQHLIDTNKIQLSRPQRFPESFQNELDNLVMSFADHMIWKNKDALEETKRANHSVARFLKRCFTFMDRGFVFKMVNNYISMFSSGDPKTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESIQELHASDMPEYSVTNEFCRKHFLIGILLREVGFALQEDQDIRHLALAVLKNLMAKHSFDDRYREPEKQAQIAGLYMPLYGMLLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFHTQSAMKHANSADTSFSKDVLNSIAAFSSIAISTVTHADSRASLASLDSNPSTTEKSSEKTDNCEKIPRPLSLIGSTLRFDKLDQAETRSLLMCFLHIMKTISEETLIAYWQRAPSPEVSDFFSILDVCLQNFRYLGKRNIIRKIAAAFKFVQSTQNNGTLKGSNPSCQTSGLLSQWMHTTSSHEGQKQHRSQTLPIIRGKNALSNPKLLQMLDNTMTSNSNEIDIVHHVDTEANIATEVCLTILDLLALFTQVHQRQLQQSECQNSMMKRVFDTYMLFFQVNQSATALKHVFASLRLFVCKFPSAFFQGPADLCGSFCYEVLKCCNHRSRSTQMEASALLYFFMRKNFEFNKQKSIVRSHLQLIKAVSQLIADAGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIAEYLKRRGYWKMEKICVPSLLLEDVHPCDSNPLLTTPSGGSMFSMGWPAFLSITPNIKEEGEMKEDSGMQDTPYNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFEKQRDFKKLSDLYYDIHRSYLKVAEVVNSEKRLFGRYYRVAFYGQGFFEEEEGKEYIYKEPKLTGLSEISQRLLKLYADKFGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDRKTDFEMHHNINRFVFETPFTLSGKKHGGVEEQCKRRTVLTTSHLFPYVKKRIQVVSQSSTELNPIEVAIDEMSKKVSELNQLCTMEEVDMIRLQLKLQGSVSVKVNAGPMAYARAFLEETNAKKYPDNQVKLLKEIFRQFADACGQALDVNERLIKEDQLEYQEELRSHYKDMLSELSAIMNEQITYRDDPSKRGVERTCSRVINKAAPSLPTVSVSPSGEV", "length": 2199, "header": "tr|E1B7C4-1|E1B7C4_BOVIN Isoform 1 of Dedicator of cytokinesis 10 OS=Bos taurus OX=9913 GN=DOCK10 PE=3 SV=3 CANONICAL=E1B7C4-1" }, "locus": { "chromosome": "2", "start_pos": 113100290, "end_pos": 112862599, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038166.5", "url": "https://www.ensembl.org/id/ENSBTAT00000038166.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037982.5", "url": "https://www.ensembl.org/id/ENSBTAP00000037982.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539421", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539421", "resource": "KEGG Pathway" }, { "id": "R-BTA-9013148", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" }, { "id": "R-BTA-9013404", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "resource": "Reactome", "description": "RAC2 GTPase cycle" }, { "id": "R-BTA-9013423", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "resource": "Reactome", "description": "RAC3 GTPase cycle" }, { "id": "R-BTA-983231", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983231", "resource": "Reactome", "description": "Factors involved in megakaryocyte development and platelet production" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0KZN9-1", "protein_name": "Dedicator of cytokinesis 10", "gene_name": "Dock10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGCAPSIVLLQAFRSVVQRSCPHICRRRQEEPSHEIVPLESDEEMMSRPRTLIMQEKPRLLEPLDYETVIEELEKTYRDDALQDLLFFPSDDFSTATVSWDIRTLYSTVPEEAEHRAESLLVKEACKFYSSQWYVVNYKYEQYSGDIRQLPRAEHKPEKLPSHSFEVDHEDADKDEDTTSHSSSKGGGGAGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGPLQGRKSAELAELGLDPLDNSVACECTLEETDSSENSLHPDFAKYLTETEDTVKTTRNTDRLNLFSLDPDIDTLKLQKRDLFEHEFMIKPFEEKAAKRIMIICRALNLNLQGCVTENENDPVTNIEPFFVSVALYDLRDNRKISADFHTDLNHPAVRQMLSGAPPALENGNIDPGTLRQSEEPHIKGLPEEWLKFPKQAIFSVSDPHSEIVLVAKVEKVLMGNIGSGTEPYIKNPDSNKFAQKILKSNRQFCSKLGKYRMPFAWAVRSVFKDNQGNVDRDSRFSPLYRQESNKISSEDLLRLVSDYRRADRISKMQTIPGSLDIVVDNIPLEQPNCVTSSFIPVKPFDVMAQSEPTVEVEEFIYDSTKHCRPYRVYKNQIYVYPKHLKYDSQKCFNKARNITVCIEFKNSDDDGARPMKCIYGKPGGPLFTSAAYTAVLHHSQNPDFSDEVKIELPTQLHGKHHLLFSFYHITCDINAKANAKKKEALETSVGYAWLPLMKHDQIASQEYNIPIATTLPPNYLSIQDPASAKHGGSDIKWVDGGKPLFKVSTFVVSTVNTQDPHVNAFFRQCQKREKDMSQSPTSSFVRACKNLLNVDKIHSIMSFLPIILNQLFKILVQNEEDEITGTVTRVLADIVAKCHEEQLDHSVQSYIKFVFKTRSYKERTIHEELAKNLSDLLKSNDSTIVKHVLKHSWFFFAIILKSMAQHLIDTDKIQLPRAQRFPESYQSELDNLVMGLCDHVIWKCKDALEETKRANHSVARFLKRCFTFMDRGFVFKMVNNYVSMFSSGEFKTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESIQELHASDMPEYSVTNEFCRKHFLIGILLREVGFALQEDQDIRHLALAVLKNLMAKHSFDDRYREPRKQAQIASLYMPLYGMLLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFQTQTSMKHATSVDTSFSKDVLNSIAAFSSIAISTVNHADSRASLASLDSNPSTAEKSSEKTDNCEKIPRPLSLIGSTLRFDKLDQAETRSLLMCFLHIMKTISDETLIAYWQRAPSPEVSDFFSILDVCLQNFRYLGKRNIIRKIAAAFKFVQSTQNNGTLKGSNPSCQTSGLLPQWMHTTSGHEGHKQHRSQTLPIIRGKNALSNPKLLQMLDNTMNSNSNEIDIVHHVDTEANIATEVCLTILDLLSLFTQVHQRQLQQSDCQNSLMRRVFDTYMLFFQVNQSASALKHVFASLRLFVCKFPSAFFQGPADLCGSFCYEVLKCCNHRSRLTQMEASALLYFFMRKNFEFNKQKSIVRSHLQLIKAVSQLIADAGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIAEYLKRKGYWKMEKICTPPLLPEDTHPCDSNLLLTTPGGGSMFSMGWPAFLSITPNIKEEGAMKEDSGMQDTPYNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFEKQRDFKKLSDLYYDIHRSYLKVAEVVNSEKRLFGRYYRVAFYGQAVGFFEEEEGKEYIYKEPKLTGLSEISQRLLKLYADKFGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDRKTDFEMHHNINRFVFETPFTLSGKKHGGVAEQCKRRTVLTTSHLFPYVKKRIQVISQSSTELNPIEVAIDEMSKKVSELNQLCTTEEVDMIRLQLKLQGSVSVKVNAGPMAYARAFLEETNAKKYPDNQVKLLKEIFRQFADACGQALDVNERLIKEDQLEYQEELRSHYKDMLGELSAIMNEQLCRGPCLYSFCSSVSSISLSTVSKSDYGQGRPSKVRTGATLHHTCN", "length": 2209 }, "evidence": [ { "id": "E1B7C4", "url": "https://omabrowser.org/oma/group/E1B7C4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M9PCG3-1", "protein_name": "Zizimin, isoform K", "gene_name": "Ziz", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MERKFTRGLNKLGSAVQMRENVSQLVRESAVLNKPLVVEPIDFEAFIAKNKTVIQNDPQRELLIYPTDDVSEIIMPRKQRTNAKSVADRFDPPNEAIVCPLHGPSMITNGNGHSQVSRQGSIQSNGSHHNGNGNGHTSSSSSSSLNNSNGHGQLSRKSSQCSNGSSSQKDSSYESALSSITLRSNLAQPEEVDEFADDGNAEDLVDGQPHGSRAECTRFTRQALYTYRAKNHLIHYKYNAYGGNCHDLPSISPAEELVEEIYEIDADQDRIDEQMTRSQADTITKQGYLLKGPDSASDRMFANIGNKSFKRRYCYLRQEIDGTYILELHKDEKQGEAKATIVMDFCTDVVQNPKRGRFCFELRMTTGHKSFTLAAENEQDFKDWLSKISSVLAQNRAQEEKRNASLERHPSIGSNPSPQLQPPAMDPPTFGTLKGLDQSLHPQLMKYGRETDHSIALARREQRRRLFACYQSPVKGSGSDNVEQYREHFGTRLLLTCHNLRFRLQCIPQDESSAGGVEQQVEPYITSLALFDAKANRKLSENFYFNVNEQWAAQLLPNTPVPSSVAGCGVPRKSAEGDERSTACQAPHSLFDGVSAELLRSNRQQFQQLRQCLLSVTAPHADIYLVVRIEKILQSGIAQVTEPYLKAGKDPKLGQKVYKAAKSYAQHIGHYRQPFAWAARPLFKQYSHELDVDPKREFEFSPIYRQEIPKLKDEELLKLLVDYRKPEKLSKLTIIPGSLKMQMQFLDQTTPCGLSKSLAPLSTFSPSSKQSPTVEVAEFQSQSERDAHPYTSFCNHLYVYPLSLQFDSQKLFSRARNITVVVELRDGDGEYSKPLKCIYGRPGQDLLVSQIACPVLHHNVTPTWYEEIKLRLPLGLFPEHHLLFSFYHVSCNLSKKRDANAAFETPIGYAWLPLLQKNRICLEEQQLPVAATLPVGYLSIQPLGWGKGNCGPDIQWIDNQRNLYTVGLRLDSTVLTADQHLHNFFGHCERLLEGGKTGAVPAETETCKILKAAHAIDMKSLINYLPTVLNELFTLLVHTQSEEIGLNVIRLITNIIHLISDQAKRSDLLGAYVKYVFHAPYYSQQTARQRTVHGELCRHLPYLLNPSNPDFLIVNKFMRYSSIFFDLIIKSMAQHLLATGRIRMLRNERFPKEYGDRVEQLIKALMPYITTRFEDLSEETHLLNRSLAKFVRQCLSYMDRGFVFRLIRCYMGEFSPGNPRILHEYKFNFLQEICQHEHYVPLNLPFVLNPKNRPPEMMQHFTLSEQFCRQHFLSGLLLQELKSSLNEVGHVRRHALGIFKDLLAKHELDNRYQQKGQLSRIALLYVPWLGVVMDNIHRIDDLSESGACTPNGHVYADSASYTKRLSCSSSYVFSKDSSTFGSLTSTPRSKNRLTMHCDQASPYRTSVHMKEHNYLAAIAGQPISNGISNLSLNSNTDSGHSQDTTTIGAYTNGDTDVALRNGHNRSVSVTHAQILSRCDKFSSVESKDLLLGFLFIIKHLSQEQMIGWWQNCNESETLQFLSILDLCLLQFRYVGKKSVVITTETRQGRLAKANTLPARTQPPTGLENGSQEQQPSSGTLNQTREHLLEDIDTLARNQLALYESNLATEVGMIILDCLGLYVLQFRQLLADSLVLPKVARVYLRFLQLGQSERLSKHVFAALRAFINNYAVALFKGNAMLCGQMVYELLKACDSRLVEIRHESCAVLYLLMRSNFEFSGRKALTRVHLQVIISVSQMIGNVIGLNNARFQESLSIINSYANSDKAMKGTGFPMEVKDLTRRVRTVLMATAQMQAHHMDPERLLELQYSLANSYASTPELRHTWLVTMARNHEQNGNLSEAACCHLHIAALMCEYLRLKGGCTLSWSSTAFGKISTNIPLDEQGLKLDAGAQDSQYTEQMLLEQLKLCADFLDRAERFECLGELYKLILPMYERDRSYQDLAHCYEHLTQAYNKIVEVNRSGKRMLGRFYRVVFYGLMYFEEDHAIEFVYKEPKLTSLSEISERLAKQYKEKFGADVVKMIMDSSPVKVDELDAKLAYIQVTHVIPFFSKDELDQRLNEFEQNHDVDTFMYETPFTKSGAARGSVEEQWKRKTVIKTQYSFPYVLKRIPVKSREIIELSPIEVAIDEMQSKVSELEEIILPPADVKKLQLRLQGSVAVTVNAGPLAYAHAFLDAKVVNNFSMDRVGDLKDVFRDFIVVCQKALFLNERIISADQKEYHHVLKENYEKLCQALSELLDDESFQPLGDDADSINQRNSMALFNAISGASHNSRPYFVDQNTSNSTHHHSSHINTQNSTHHS", "length": 2298 }, "evidence": [ { "id": "E1B7C4", "url": "https://omabrowser.org/oma/group/E1B7C4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q8BZN6-1", "protein_name": "Dedicator of cytokinesis protein 10", "gene_name": "Dock10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGERTRRFTRSLLRPGQAAELRHSAASAAAVAVSSRQQQRQEKPRLLDPLDYETVIEELEKTYRDDPLQDLLFFPSDDFSTATVSWDIRTLYSTVPEEAEHRAESLLVKEACKFYSSQWYVVNYKYEQYSGDIRQLPRAEHKPEKLPSHSFEVDHEDADKDEDTTSHSSSKGGGGAGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGPLQGRKSAELAELGLDPLDNCVTCECTLEETDSSENSLHPDFAKYLTETEDTVKTTRNMGRLNLFSLDPDIDTLKLQKRDSFENELMIKPFEEKAAKRIMIICRALNFNLQGCVTENEYDPVTNIEPFFVSVALYDLRDNRKISADFHVDLNHPAVRQMLSGTPPALENGNIDTGTPRQSEEPHIKGLPEEWLKFPKQAVFSVSDPHSEIVLVAKVEKVLMGNIGSGAEPYIKNPDSNKFAQKILKSNRQFCSKLGKYRMPFAWAVRSVFKDNQGNVDRDSRFSPLYRQESSKMSSEDLLKLVSDYRRADRISKMQSIPGSLDIAVDNIPLEHPNCVTSSFIPVKPFNVSAQSEPTVEVEEFIYDSTKYCRPYRVYKNQIYVYPKHLKYDSQKCFNKARNITVCIEFKNSDDDGAKPMKCIYGKPGGPLFTSSAYTAVLHHSQNPDFSDEVKIELPTQLHGKHHLLFSFYHITCDINAKANAKKKEALETSVGYAWLPLMKHDQIASQEYNIPIATTLPPNYLSIQDPTSAKHGGSDIKWVDGGKPLFKVSTFVVSTVNTQDPHVNAFFRQCQKREKDMSQSPTSSFVRACKNLLNVDKIHSIMSFLPIILNQLFKILVQNEEDEITATVTRVLADIVAKCHEEQLDHSVQSYIKFVFKTKSYKERTIHEELAKNLSDLLKSNDSTIVKHVLEHSWFFFAIILKSMAQHLIDTNKIQLPRAQRFPESYQSELDNLVMGLCDHVIWKCKEAPEETKRANHSVARFLKRCFTFMDRGFVFKMVNNYISMFSSGEFKTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESIRELHASDMPEYSVTNEFCRKHFLIGILLREVGFALQEDQDIRHLALAVLKNLMAKHSFDDRYREPRKQAQIASLYMPLYGMLLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFQTQTSMKHATSVDTSFSKDVLNSIAAFSSIAISTVNHADSRASLASLDSNPSTTEKSSEKTDNCEKIPRPLSLIGSTLRFDKLDQAETRSLLMCFLHIMKTISDETLIAYWQRAPSPEVSDFFSILDVCLQNFRYLGKRNIIRKIAAAFKFVQSTQNNGTLKGSNPSCQTSGLLSQWMHTTSGHEGHKQHRSQTLPIIRGKNALSNPKLLQMLDNSMNSNSNEIDIVHHVDTEANIATEVCLTILDLLSLFTQVHQRQLQQSDCQNSLMKRVFDTYMLFFQVNQSASALKHVFASLRLFVCKFPSAFFQGPADLCGSFCYEVLKCCNHRSRLTQMEASALLYFFMRKNFEFNKQKSIVRSHLQLIKAVSQLIADAGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIAEYLKRKGYWKMEKICTPPLLPEDTQPCDSNLLLTTPGGGSMFSMGWPAFLSITPNIKEEGAMKEDSGMQDTPYNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFEKQRDFKKLSDLYYDIHRSYLKVAEVVNSEKRLFGRYYRVAFYGQGFFEEEEGKEYIYKEPKLTGLSEISQRLLKLYADKFGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDRKTDFEMHHNINRFVFETPFTLSGKKHGGVAEQCKRRTVLTTSHLFPYVKKRIQVISQSSTELNPIEVAIDEMSRKVSELNQLCTTEEVDMIRLQLKLQGSVSVKVNAGPMAYARAFLEETNAKKYPDNQVKLLKEIFRQFADACGQALDVNERLIKEDQLEYQEELRSHYKDMLSELSAIMNEQITGRDDPAKCGVERPYTTRVTSKGTAAVPVVSISSSAEV", "length": 2187 }, "evidence": [ { "id": "E1B7C4", "url": "https://omabrowser.org/oma/group/E1B7C4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96BY6-1", "protein_name": "Dedicator of cytokinesis protein 10", "gene_name": "DOCK10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGERTRRFTRSLLRPGQAAELRHSAASAAAVAVSSRQQQRQEKPRLLEPLDYETVIEELEKTYRNDPLQDLLFFPSDDFSAATVSWDIRTLYSTVPEDAEHKAENLLVKEACKFYSSQWHVVNYKYEQYSGDIRQLPRAEYKPEKLPSHSFEIDHEDADKDEDTTSHSSSKGGGGAGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGPLQGRRSTELTDLGLDSLDNSVTCECTPEETDSSENNLHADFAKYLTETEDTVKTTRNMERLNLFSLDPDIDTLKLQKKDLLEPESVIKPFEEKAAKRIMIICKALNSNLQGCVTENENDPITNIEPFFVSVALYDLRDSRKISADFHVDLNHAAVRQMLLGASVALENGNIDTITPRQSEEPHIKGLPEEWLKFPKQAVFSVSNPHSEIVLVAKIEKVLMGNIASGAEPYIKNPDSNKYAQKILKSNRQFCSKLGKYRMPFAWAVRSVFKDNQGNVDRDSRFSPLFRQESSKISTEDLVKLVSDYRRADRISKMQTIPGSLDIAVDNVPLEHPNCVTSSFIPVKPFNMMAQTEPTVEVEEFVYDSTKYCRPYRVYKNQIYIYPKHLKYDSQKCFNKARNITVCIEFKNSDEESAKPLKCIYGKPGGPLFTSAAYTAVLHHSQNPDFSDEVKIELPTQLHEKHHILFSFYHVTCDINAKANAKKKEALETSVGYAWLPLMKHDQIASQEYNIPIATSLPPNYLSFQDSASGKHGGSDIKWVDGGKPLFKVSTFVVSTVNTQDPHVNAFFQECQKREKDMSQSPTSNFIRSCKNLLNVEKIHAIMSFLPIILNQLFKVLVQNEEDEITTTVTRVLTDIVAKCHEEQLDHSVQSYIKFVFKTRACKERTVHEELAKNVTGLLKSNDSTTVKHVLKHSWFFFAIILKSMAQHLIDTNKIQLPRPQRFPESYQNELDNLVMVLSDHVIWKYKDALEETRRANHSVARFLKRCFTFMDRGYVFKMVNNYISMFSSGDLKTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESTQELHASDMPEYSVTNEFCRKHFLIGILLREVGFALQEDQDVRHLALAVLKNLMAKHSFDDRYREPRKQAQIASLYMPLYGMLLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFQSQTAIKHANSVDTSFSKDVLNSIAAFSSIAISTVNHADSRASLASLDSNPSTNEKSSEKTDNCEKIPRPLSLIGSTLRFDKLDQAETRSLLMCFLHIMKTISYETLIAYWQRAPSPEVSDFFSILDVCLQNFRYLGKRNIIRKIAAAFKFVQSTQNNGTLKGSNPSCQTSGLLSQWMHSTSSHEGHKQHRSQTLPIIRGKNALSNPKLLQMLDNTMTSNSNEIDIVHHVDTEANIATEVCLTILDLLSLFTQTHQRQLQQCDCQNSLMKRVFDTYMLFFQVNQSATALKHVFASLRLFVCKFPSAFFQGPADLCGSFCYEVLKCCNHRSRSTQTEASALLYFFMRKNFEFNKQKSIVRSHLQLIKAVSQLIADAGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIAEYLKRKGYWKVEKICTASLLSEDTHPCDSNSLLTTPSGGSMFSMGWPAFLSITPNIKEEGAMKEDSGMQDTPYNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFEKQRDFKKLSDLYYDIHRSYLKVAEVVNSEKRLFGRYYRVAFYGQGFFEEEEGKEYIYKEPKLTGLSEISQRLLKLYADKFGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDRKTDFEMHHNINRFVFETPFTLSGKKHGGVAEQCKRRTILTTSHLFPYVKKRIQVISQSSTELNPIEVAIDEMSKKVSELNQLCTMEEVDMIRLQLKLQGSVSVKVNAGPMAYARAFLEETNAKKYPDNQVKLLKEIFRQFADACGQALDVNERLIKEDQLEYQEELRSHYKDMLSELSTVMNEQITGRDDLSKRGVDQTCTRVISKATPALPTVSISSSAEV", "length": 2186 }, "evidence": [ { "id": "E1B7C4", "url": "https://omabrowser.org/oma/group/E1B7C4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "E1B7C4", "url": "https://www.uniprot.org/uniprotkb/E1B7C4" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "E1B7C4", "url": "https://www.uniprot.org/uniprotkb/E1B7C4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "small GTPase-mediated signal transduction", "id": "GO:0007264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264", "evidence": [ { "database": "UniProtKB", "id": "E1B7C4", "url": "https://www.uniprot.org/uniprotkb/E1B7C4" } ], "pmid": "" }, { "name": "regulation of Rho protein signal transduction", "id": "GO:0035023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035023", "evidence": [ { "database": "UniProtKB", "id": "E1B7C4", "url": "https://www.uniprot.org/uniprotkb/E1B7C4" } ], "pmid": "" }, { "name": "regulation of cell migration", "id": "GO:0030334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030334", "evidence": [ { "database": "UniProtKB", "id": "E1B7C4", "url": "https://www.uniprot.org/uniprotkb/E1B7C4" } ], "pmid": "" }, { "name": "dendritic spine morphogenesis", "id": "GO:0060997", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060997", "evidence": [ { "database": "UniProtKB", "id": "E1B7C4", "url": "https://www.uniprot.org/uniprotkb/E1B7C4" } ], "pmid": "" }, { "name": "B cell homeostasis", "id": "GO:0001782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001782", "evidence": [ { "database": "UniProtKB", "id": "E1B7C4", "url": "https://www.uniprot.org/uniprotkb/E1B7C4" } ], "pmid": "" }, { "name": "marginal zone B cell differentiation", "id": "GO:0002315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002315", "evidence": [ { "database": "UniProtKB", "id": "E1B7C4", "url": "https://www.uniprot.org/uniprotkb/E1B7C4" } ], "pmid": "" }, { "name": "regulation of postsynapse assembly", "id": "GO:0150052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150052", "evidence": [ { "database": "UniProtKB", "id": "E1B7C4", "url": "https://www.uniprot.org/uniprotkb/E1B7C4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "E1B7C4", "url": "https://www.uniprot.org/uniprotkb/E1B7C4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1B7C4", "url": "https://www.uniprot.org/uniprotkb/E1B7C4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B7C4", "url": "https://www.uniprot.org/uniprotkb/E1B7C4" } ], "pmid": "" }, { "name": "dendritic spine", "id": "GO:0043197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043197", "evidence": [ { "database": "UniProtKB", "id": "E1B7C4", "url": "https://www.uniprot.org/uniprotkb/E1B7C4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1066, "end_pos": 1068, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1243, "end_pos": 1245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1417, "end_pos": 1419, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1542, "end_pos": 1544, "annotation": "n_glycosylation_sequon" }, { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" }, { "start_pos": 460, "end_pos": 462, "annotation": "n_glycosylation_sequon" }, { "start_pos": 656, "end_pos": 658, "annotation": "n_glycosylation_sequon" }, { "start_pos": 708, "end_pos": 710, "annotation": "n_glycosylation_sequon" }, { "start_pos": 983, "end_pos": 985, "annotation": "n_glycosylation_sequon" }, { "start_pos": 991, "end_pos": 993, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7C4" }, { "id": "PS51650", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51650" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2 DOCK-type", "eco_id": "ECO_0000259", "start_pos": 685, "end_pos": 863, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B7C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7C4" }, { "id": "PS51651", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51651" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DOCKER", "eco_id": "ECO_0000259", "start_pos": 1703, "end_pos": 2163, "start_aa": "Asn", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B7C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7C4" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 194, "end_pos": 303, "start_aa": "Gly", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1066, "end_pos": 1068 }, { "start_pos": 1243, "end_pos": 1245 }, { "start_pos": 1417, "end_pos": 1419 }, { "start_pos": 1542, "end_pos": 1544 }, { "start_pos": 207, "end_pos": 209 }, { "start_pos": 211, "end_pos": 213 }, { "start_pos": 460, "end_pos": 462 }, { "start_pos": 656, "end_pos": 658 }, { "start_pos": 708, "end_pos": 710 }, { "start_pos": 983, "end_pos": 985 }, { "start_pos": 991, "end_pos": 993 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B8D2-1", "uniprot_ac": "E1B8D2", "uniprot_id": "E1B8D2_BOVIN", "mass": { "chemical_mass": 92602.0, "monoisotopic_mass": 92602.0 }, "refseq": { "ac": "NP_001192428", "name": "mutS protein homolog 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192428" }, "gene_names": [ { "name": "MSH5", "type": "recommended", "evidence": [ { "id": "E1B8D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8D2" } ] }, { "name": "MSH5", "type": "synonym", "evidence": [ { "id": "NP_001192428", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192428" } ] } ], "protein_names": [ { "name": "MutS protein homolog 5", "type": "recommended", "evidence": [ { "id": "E1B8D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8D2/entry#names_and_taxonomy" } ] }, { "name": "mutS protein homolog 5", "type": "synonym", "evidence": [ { "id": "NP_001192428", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192428" } ] } ], "function": [ { "annotation": "Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis.", "evidence": [ { "database": "UniProtKB", "id": "E1B8D2", "url": "https://www.uniprot.org/uniprotkb/E1B8D2#function" }, { "database": "UniProtKB", "id": "ARBA00057350", "url": "https://www.uniprot.org/uniprotkb/ARBA00057350#function" }, { "database": "UniProtKB", "id": "A0AAA9TC87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC87#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8D2", "url": "https://www.uniprot.org/uniprotkb/E1B8D2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MSH5", "url": "https://www.uniprot.org/uniprotkb/E1B8D2", "locus": { "chromosome": "23", "start_pos": 27558176, "end_pos": 27578112, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019790", "url": "https://www.ensembl.org/id/ENSBTAG00000019790" } ] } } ], "crossref": [ { "id": "E1B8D2", "url": "https://alphafold.ebi.ac.uk/entry/E1B8D2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019790", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019790", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03281", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03281", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100139295", "url": "https://www.ncbi.nlm.nih.gov/gene/100139295", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000432", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000432", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007696", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007696", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007861", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007861", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011184", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011184", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045076", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045076", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100139295", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100139295", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CSVYFMP", "url": "https://omabrowser.org/oma/group/CSVYFMP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8D2", "url": "https://www.orthodb.org/?gene=E1B8D2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11361", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11361", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11361:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11361:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00488", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00488", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05190", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05190", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05192", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05192", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27035", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27035", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192428", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TC87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC87-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8D2", "url": "https://www.uniprot.org/uniprotkb/E1B8D2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8D2-1", "url": "https://www.uniprot.org/uniprotkb/E1B8D2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASVAATPTRTPNGPGPGEASASFPTVASDPGPREPEEEGEEEPAEIHLCVLWNSGYLGIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDEIDPRSVVTSAKQDENMTRFLGKLASQEHREPKRPEIIFLPSVDFGLEISKQRLLSGNYSFLPDSMTTTEKILFLSSIIPFDCLLMVRALGGLLKFLGRRRIGVELEDYNVSVPILGFKKFVLTNLVSIDQDTYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCRCKWGEKLLRLWFTRPTQDLGELNSRLDVIQFFLLPQNLDMAQMLHRLLGHIKNVPLILKRMTLSHTKVSDWQVLYKTVYSALGLRDACRSLPQSIQLFRDIAQEFSDDLHHIASLIGKVVDFEGSLAENRFTVLPNIDPEIDEKKRRLMGLPSFLTEVARKELENLDSRIPSCSVIYIPLIGFLLSIPRLPSMVETSDFEIEGLDFMFLSEEKLHYRSARTKELDALLGDLHCDIRDQETLLMHQLQCQVLARAAVLTRVLDLASRLDVLLALASAARDYGYSRPRYSPRLLGVRIQNGRHPLMELCARTFVPNSAECGGDAGRVKVITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGAVDAIFTRIHSCESISLGLSTFMIDLNQQVAKAVNNATERSLVLVDEFGKGTNTVDGLALLAAVIRHWLALGPTCPHVFVATNFLSLVQLQLLPRGPLVQYLTMETCEDGDDLVFFYQVCEGVARASHASHTAAQAGLPEKLIARGKQVSDLIRSGKPIKPVKELLKEKQMENCQTLVDKFLKLDLEDPSLDLDIFMSQEVLPAATTIL", "length": 832, "header": "tr|E1B8D2-1|E1B8D2_BOVIN Isoform 1 of MutS protein homolog 5 OS=Bos taurus OX=9913 GN=MSH5 PE=3 SV=2 CANONICAL=E1B8D2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TC87-1", "url": "https://www.uniprot.org/uniprotkb/E1B8D2/entry#A0AAA9TC87-1", "sequence": { "sequence": "MGPEGASKAMASVAATPTRTPNGPGPGEASASFPTVASDPGPREPEEEGEEEPAEIHLCVLWNSGYLGIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDEIDPRSVVTSAKQDENMTRFLGKLASQEHREPKRPEIIFLPSVDFGLEISKQRLLSGNYSFLPDSMTTTEKILFLSSIIPFDCLLMVRALGGLLKFLGRRRIGVELEDYNVSVPILGFKKFVLTNLVSIDQDTYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCRCKWGEKLLRLWFTRPTQDLGELNSRLDVIQFFLLPQNLDMAQMLHRLLGHIKNVPLILKRMTLSHTKVSDWQVLYKTVYSALGLRDACRSLPQSIQLFRDIAQEFSDDLHHIASLIGKVVDFEGSLAENRFTVLPNIDPEIDEKKRRLMGLPSFLTEVARKELENLDSRIPSCSVIYIPLIGFLLSIPRLPSMVETSDFEIEGLDFMFLSEEKLHYRSARTKELDALLGDLHCDIRDQETLLMHQLQCQVLARAAVLTRVLDLASRLDVLLALASAARDYGYSRPRYSPRLLGVRIQNGRHPLMELCARTFVPNSAECGGDAGRVKVITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGAVDAIFTRIHSCESISLGLSTFMIDLNQVAKAVNNATERSLVLVDEFGKGTNTVDGLALLAAVIRHWLALGPTCPHVFVATNFLSLVQLQLLPRGPLVQYLTMETCEDGDDLVFFYQVCEGVARASHASHTAAQAGLPEKLIARGKQVSDLIRSGKPIKPVKELLKEKQMENCQTLVDKFLKLDLEDPSLDLDIFMSQEVLPAATTIL", "length": 840, "header": "tr|A0AAA9TC87-1|E1B8D2_BOVIN Computationally mapped isoform of MutS protein homolog 5 OS=Bos taurus OX=9913 GN=MSH5 PE=3 SV=1 CANONICAL=E1B8D2-1" }, "locus": { "chromosome": "23", "start_pos": 27575518, "end_pos": 27558317, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123837.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123837.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094343.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094343.1" } ] } }, { "isoform_ac": "E1B8D2-1", "url": "https://www.uniprot.org/uniprotkb/E1B8D2/entry#E1B8D2-1", "sequence": { "sequence": "MASVAATPTRTPNGPGPGEASASFPTVASDPGPREPEEEGEEEPAEIHLCVLWNSGYLGIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDEIDPRSVVTSAKQDENMTRFLGKLASQEHREPKRPEIIFLPSVDFGLEISKQRLLSGNYSFLPDSMTTTEKILFLSSIIPFDCLLMVRALGGLLKFLGRRRIGVELEDYNVSVPILGFKKFVLTNLVSIDQDTYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCRCKWGEKLLRLWFTRPTQDLGELNSRLDVIQFFLLPQNLDMAQMLHRLLGHIKNVPLILKRMTLSHTKVSDWQVLYKTVYSALGLRDACRSLPQSIQLFRDIAQEFSDDLHHIASLIGKVVDFEGSLAENRFTVLPNIDPEIDEKKRRLMGLPSFLTEVARKELENLDSRIPSCSVIYIPLIGFLLSIPRLPSMVETSDFEIEGLDFMFLSEEKLHYRSARTKELDALLGDLHCDIRDQETLLMHQLQCQVLARAAVLTRVLDLASRLDVLLALASAARDYGYSRPRYSPRLLGVRIQNGRHPLMELCARTFVPNSAECGGDAGRVKVITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGAVDAIFTRIHSCESISLGLSTFMIDLNQQVAKAVNNATERSLVLVDEFGKGTNTVDGLALLAAVIRHWLALGPTCPHVFVATNFLSLVQLQLLPRGPLVQYLTMETCEDGDDLVFFYQVCEGVARASHASHTAAQAGLPEKLIARGKQVSDLIRSGKPIKPVKELLKEKQMENCQTLVDKFLKLDLEDPSLDLDIFMSQEVLPAATTIL", "length": 832, "header": "tr|E1B8D2-1|E1B8D2_BOVIN Isoform 1 of MutS protein homolog 5 OS=Bos taurus OX=9913 GN=MSH5 PE=3 SV=2 CANONICAL=E1B8D2-1" }, "locus": { "chromosome": "23", "start_pos": 27571478, "end_pos": 27558317, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026367.5", "url": "https://www.ensembl.org/id/ENSBTAT00000026367.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026367.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026367.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 697, "start_aa": "Thr", "end_pos": 697, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr697", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100139295", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100139295", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F4JEP5-1", "protein_name": "DNA mismatch repair protein MSH5", "gene_name": "MSH5", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEEMEDTETEPQVYMACIQHGRRVGVSYYDCSVRQLHVLEFWEEDCSDFTLINMVKYQAKPSIIYASTKSEESFVAALQQNDGTDETTMVKLVKSSTFSYEQAWHRLVYLRVTGMDDGLNIKERICYLSSMMDVGSEVQVRVSGGLLAILESERIVETLEQNESGSASIAIDSVMEVPLNKFLKLDAAAHEALQIFQTDKHPSHMGIGRAKEGFSVFGMMNKCATPMGRRLLRSWFMRPILDLEVLDRRLNAISFFISSVELMASLRETLKSVKDISHLLKKFNSPTSLCTSNDWTAFLKSISALLHVNKIFEVGVSESLREHMRRFNLDIIEKAGLCISTELDYVYELVIGVIDVTRSKERGYQTLVKEGFCAELDELRQIYEELPEFLQEVSAMELEHFPHLHKEKLPPCIVYIQQIGYLMCIFGEKLDETALNRLTEFEFAFSDMDGETQRFFYHTSKTRELDNLLGDIYHKILDMERAIIRDLLSHTLLFSAHLLKAVNFVAELDCILSLACVAHQNNYVRPVLTVESLLDIRNGRHVLQEMAVDTFIPNDTEINDNGRIHIITGPNYSGKSIYVKQVALIVFLSHIGSFVPADAATVGLTDRIFCAMGSKFMTAEQSTFMIDLHQVGMMLRQATSRSLCLLDEFGKGTLTEDGIGLLGGTISHFATCAEPPRVVVCTHLTELLNESCLPVSEKIKFYTMSVLRPDTESANMEEIVFLYRLIPGQTLLSYGLHCALLAGVPEEVVKRAAIVLDAFESNNNVDKLSLDKISSQDQAFKDAVDKFAELDISKGDIHAFFQDIFTS", "length": 807 }, "evidence": [ { "id": "E1B8D2", "url": "https://omabrowser.org/oma/group/E1B8D2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "O43196-1", "protein_name": "MutS protein homolog 5", "gene_name": "MSH5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASLGANPRRTPQGPRPGAASSGFPSPAPVPGPREAEEEEVEEEEELAEIHLCVLWNSGYLGIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDEINPQSVVTSAKQDENMTRFLGKLASQEHREPKRPEIIFLPSVDFGLEISKQRLLSGNYSFIPDAMTATEKILFLSSIIPFDCLLTVRALGGLLKFLGRRRIGVELEDYNVSVPILGFKKFMLTHLVNIDQDTYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCHCKWGEKLLRLWFTRPTHDLGELSSRLDVIQFFLLPQNLDMAQMLHRLLGHIKNVPLILKRMKLSHTKVSDWQVLYKTVYSALGLRDACRSLPQSIQLFRDIAQEFSDDLHHIASLIGKVVDFEGSLAENRFTVLPNIDPEIDEKKRRLMGLPSFLTEVARKELENLDSRIPSCSVIYIPLIGFLLSIPRLPSMVEASDFEINGLDFMFLSEEKLHYRSARTKELDALLGDLHCEIRDQETLLMYQLQCQVLARAAVLTRVLDLASRLDVLLALASAARDYGYSRPRYSPQVLGVRIQNGRHPLMELCARTFVPNSTECGGDKGRVKVITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGAVDAIFTRIHSCESISLGLSTFMIDLNQVAKAVNNATAQSLVLIDEFGKGTNTVDGLALLAAVLRHWLARGPTCPHIFVATNFLSLVQLQLLPQGPLVQYLTMETCEDGNDLVFFYQVCEGVAKASHASHTAAQAGLPDKLVARGKEVSDLIRSGKPIKPVKDLLKKNQMENCQTLVDKFMKLDLEDPNLDLNVFMSQEVLPAATSIL", "length": 834 }, "evidence": [ { "id": "E1B8D2", "url": "https://omabrowser.org/oma/group/E1B8D2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q12175-1", "protein_name": "MutS protein homolog 5", "gene_name": "MSH5", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSHEWLISASETMRSIGNGEGLRDKGAVVANNDGEFNEGDTNREEDSSTIFSFDFDEEIVMCIDFSGGKLGCSILDYHTKTLKAFDQDYVVNKTTISSHDLIDDADMSSNDISLLLGLLIMEANPTVCLVPARLEDWIFDYIKTKCDEINCRLELQPIKRFKKWDLLQSLQLRGHDNQTILNDILSNSKFTTTVTLGTVGCILANHEQLGEYNDSTASSNMVTGRLVQNAFEDVIHGIRYIDIRDRMVLDENTISALHIFPTAHKLGHDKMMRNGFFSVFELFNQVSSDYARRILKSWLINPLTNKKRIETRYSIIRTLLDKQNAIIFSDLSQSIKRCPDAFGFINQLRSGKSTLGTWSKVASFLEKGIAIFQLVSSLKLGSDEANILHDIKNKVDISALKECLRKVETVIDFDTSRDTKTLTINTGVDNRLDECRNIYNHLEGILLDVARETQIFLLNTMPQEDCKTTKSLEKLVNAVYIPQLGYLVTISVLMEPLLDGIPNLQWEEIFRSSENIYFKNGRVLELDETYGDIYGAISDFEIEILFSLQEQILRRKTQLTAYNILLSELEILLSFAQVSAERNYAEPQLVEDECILEIINGRHALYETFLDNYIPNSTMIDGGLFSELSWCEQNKGRIIVVTGANASGKSVYLTQNGLIVYLAQIGCFVPAERARIGIADKILTRIRTQETVYKTQSSFLLDSQQMAKSLSLATEKSLILIDEYGKGTDILDGPSLFGSIMLNMSKSEKCPRIIACTHFHELFNENVLTENIKGIKHYCTDILISQKYNLLETAHVGEDHESEGITFLFKVKEGISKQSFGIYCAKVCGLSRDIVERAEELSRMINRGDDVVQQCGNLTEKEMREFQKNQEIVKKFLSWDLDLETTTTSENLRLKLKNFLR", "length": 901 }, "evidence": [ { "id": "E1B8D2", "url": "https://omabrowser.org/oma/group/E1B8D2/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54P75-1", "protein_name": "DNA mismatch repair proteins mutS family domain-containing protein", "gene_name": "msh5", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNTHNILINNQSPIGWVDNEIPPHHIIGSNKSINENTNGISNDNIEIDNQSHSILAVFYQDLKIGVAYYDRLESNIYLCQCWEDENFSCLNSIKQLINPKVIIIPSRMPQKFIDNILRNLDDSNENNEKQTSKNTQYHYSRFSDFTFESSKNRLLNLKLSMCNTNNTTIKYTFLQNVFNFDNIEMIRAVGGLLSYLSKYILLDDFDSLDNLIINEICPITLNQYLLLDNNTLFSLQIFSNQNHPSCYSFGNSKEGLSLFGLFDKTKTTMGKKLLKTWFMRPSRNRFVIEERQNLIQFFSSQENSSLKFELLDNLKNIKDLKIILSRISSSQNPSKDFISIYKTFHYFLKIKLLIVPKNSELPFLKKLNNLYPQSLVNIYQKFESIFFFADQDDQRISIREGVDEELDQLRNVYLSMDEILTEHGELERVKFTNLTWITSFHLVYYPQLGCLICIPIEESIAIGNQINIPSLSFIFKTSSYLYFQNQKTKELDDFFGDIHNDILDIQSRIEKEVVDEIMSNSGSIIDLCNYCTQLDCILSLASCVQAYDLVKPIISTEQQEIEIQSGRHLIQEYCVTNFIPNDTQNDPTKPVVIVSGPNQSGKSIYIKQVALIVFLGQIGSYVPAKSATISLFDHIYTRISSRESNAISESSFMIDCKQIAQMTRFATSRSLLIIDEYGKGTNPLDGISLLYGLLVFLLTKSPSTPKTFICTHFYEFFELISNSTDSIFNKVLFNTMEFVIETNNNQNNNNKFLDLQSTNTTTNTKTNNNNIFNTTNKITNTNNKPNEFIPFYKLKEGISSSSFGILCAKIAGVNENVVNRAYEIMDHQKQYKTINCQNFEPISPNQSKIKKYNELLDYFENFDPNKDSFENLFSIINKYD", "length": 880 }, "evidence": [ { "id": "E1B8D2", "url": "https://omabrowser.org/oma/group/E1B8D2/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6MG62-1", "protein_name": "MutS protein homolog 5", "gene_name": "Msh5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAFRATPGRTPPGPGPGVPSASFSSPQPAMAAPGGIEEEDEEEPAEIHLCVLWSSGYLGIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDEINPQSVVTSAKQDEAMTQFLGKLASQEHREPKRPEIILLPSVDFGPEISKQRLLSGNYSFISESMTATEKILFLSSIIPFDCVLTVRALGGLLKFLSRRRVGVELEDYSVGVPILGFKKFVLTHLVSIDQDTYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCRCRWGQKLLRLWFTRPTRELRELNSRLDVIEFFLMPQNLDMAQMMHRLLSHIKNVPLILKRMKLSHTKVSDWQVLYKTVYSALGLRDACRSLPQSIQLFRDITQEFSDDLHHIASLIGKVVDFEESLAENRFTVLPNIDPEIDAKKRRLMGLPSFLTEVAQKELENLDSCIPSCSVIYIPLIGFLLSIPRLSFMVEASDFEIEGLDFMFLSEDKLHYRSARTKELDALLGDLHCEIRDQEMLLMHQLQCQVLARAPVLTRVLDLASRLDVLLALASAARDYGYSRPHYSPCIQGVRIKNGRHPLMELCARTFVPNSTDCGGDQGRVKVITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGVIDAIFTRIHSCESISLGLSTFMIDLNQVAKAVNNATEHSLVLIDEFGKGTNSVDGLALLTAVLRHWLALGPSCPHIFVATNFLSLVQLQLLPQGPLVQYLTMETCEDGNDLVFFYQLCHGVASASHASYTAAQAGLPDPLIARGKEVSDSIRSGKPVKPMHELVRRTQMENCQALVDKFLKLDLEDPSLDLDIFISQEVLPAATTIL", "length": 831 }, "evidence": [ { "id": "E1B8D2", "url": "https://omabrowser.org/oma/group/E1B8D2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9QUM7-1", "protein_name": "MutS protein homolog 5", "gene_name": "Msh5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFRATPGRTPPGPGPRSGIPSASFPSPQPPMAGPGGIEEEDEEEPAEIHLCVLWSSGYLGIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDEINPQSVVTSAKQDEAMTRFLGKLASEEHREPKGPEIILLPSVDFGPEISKQRLLSGNYSFISDSMTATEKILFLSSIIPFDCVLTVRALGGLLKFLSRRRIGVELEDYDVGVPILGFKKFVLTHLVSIDQDTYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCRCKWGQKLLRLWFTRPTRELRELNSRLDVIQFFLMPQNLDMAQMLHRLLSHIKNVPLILKRMKLSHTKVSDWQVLYKTVYSALGLRDACRSLPQSIQLFQDIAQEFSDDLHHIASLIGKVVDFEESLAENRFTVLPNIDPDIDAKKRRLIGLPSFLTEVAQKELENLDSRIPSCSVIYIPLIGFLLSIPRLPFMVEASDFEIEGLDFMFLSEDKLHYRSARTKELDTLLGDLHCEIRDQETLLMYQLQCQVLARASVLTRVLDLASRLDVLLALASAARDYGYSRPHYSPCIHGVRIRNGRHPLMELCARTFVPNSTDCGGDQGRVKVITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEIGVIDAIFTRIHSCESISLGLSTFMIDLNQVAKAVNNATEHSLVLIDEFGKGTNSVDGLALLAAVLRHWLALGPSCPHVFVATNFLSLVQLQLLPQGPLVQYLTMETCEDGEDLVFFYQLCQGVASASHASHTAAQAGLPDPLIARGKEVSDLIRSGKPIKATNELLRRNQMENCQALVDKFLKLDLEDPTLDLDIFISQEVLPAAPTIL", "length": 833 }, "evidence": [ { "id": "E1B8D2", "url": "https://omabrowser.org/oma/group/E1B8D2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1B8D2", "url": "https://www.uniprot.org/uniprotkb/E1B8D2" } ], "pmid": "" }, { "name": "mismatched DNA binding", "id": "GO:0030983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030983", "evidence": [ { "database": "UniProtKB", "id": "E1B8D2", "url": "https://www.uniprot.org/uniprotkb/E1B8D2" } ], "pmid": "" }, { "name": "ATP-dependent DNA damage sensor activity", "id": "GO:0140664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140664", "evidence": [ { "database": "UniProtKB", "id": "E1B8D2", "url": "https://www.uniprot.org/uniprotkb/E1B8D2" } ], "pmid": "" }, { "name": "double-stranded DNA binding", "id": "GO:0003690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690", "evidence": [ { "database": "UniProtKB", "id": "E1B8D2", "url": "https://www.uniprot.org/uniprotkb/E1B8D2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mismatch repair", "id": "GO:0006298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006298", "evidence": [ { "database": "UniProtKB", "id": "E1B8D2", "url": "https://www.uniprot.org/uniprotkb/E1B8D2" } ], "pmid": "" }, { "name": "meiosis I", "id": "GO:0007127", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007127", "evidence": [ { "database": "UniProtKB", "id": "E1B8D2", "url": "https://www.uniprot.org/uniprotkb/E1B8D2" } ], "pmid": "" }, { "name": "chiasma assembly", "id": "GO:0051026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051026", "evidence": [ { "database": "UniProtKB", "id": "E1B8D2", "url": "https://www.uniprot.org/uniprotkb/E1B8D2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B8D2", "url": "https://www.uniprot.org/uniprotkb/E1B8D2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 200, "end_pos": 202, "annotation": "n_glycosylation_sequon" }, { "start_pos": 591, "end_pos": 593, "annotation": "n_glycosylation_sequon" }, { "start_pos": 659, "end_pos": 661, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B8D2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 832, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B8D2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B8D2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8D2" }, { "id": "PS00486", "database": "PROSITE", "url": "https://prosite.expasy.org/PS00486" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DNA mismatch repair proteins mutS family", "eco_id": "ECO_0000259", "start_pos": 664, "end_pos": 680, "start_aa": "Ser", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 697 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 148, "end_pos": 150 }, { "start_pos": 200, "end_pos": 202 }, { "start_pos": 591, "end_pos": 593 }, { "start_pos": 659, "end_pos": 661 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BA50-1", "uniprot_ac": "E1BA50", "uniprot_id": "E1BA50_BOVIN", "mass": { "chemical_mass": 47392.0, "monoisotopic_mass": 47392.0 }, "refseq": {}, "gene_names": [ { "name": "LIPM", "type": "recommended", "evidence": [ { "id": "E1BA50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA50" } ] } ], "protein_names": [ { "name": "Lipase", "type": "recommended", "evidence": [ { "id": "E1BA50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BA50/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol. Shows a preferential hydrolysis at the sn-3 position of triacylglycerol.", "evidence": [ { "database": "UniProtKB", "id": "E1BA50", "url": "https://www.uniprot.org/uniprotkb/E1BA50#function" }, { "database": "UniProtKB", "id": "ARBA00045163", "url": "https://www.uniprot.org/uniprotkb/ARBA00045163#function" }, { "database": "UniProtKB", "id": "A0AAA9TG67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG67#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BA50", "url": "https://www.uniprot.org/uniprotkb/E1BA50" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LIPM", "url": "https://www.uniprot.org/uniprotkb/E1BA50", "locus": { "chromosome": "26", "start_pos": 10505439, "end_pos": 10469411, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013364", "url": "https://www.ensembl.org/id/ENSBTAG00000013364" } ] } } ], "crossref": [ { "id": "E1BA50", "url": "https://alphafold.ebi.ac.uk/entry/E1BA50", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013364", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013364", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GHMPTKA", "url": "https://omabrowser.org/oma/group/GHMPTKA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BA50", "url": "https://www.orthodb.org/?gene=E1BA50", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11005", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11005", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00561", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00561", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6809371", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "12044", "url": "https://www.rhea-db.org/rhea/12044", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "39931", "url": "https://www.rhea-db.org/rhea/39931", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40047", "url": "https://www.rhea-db.org/rhea/40047", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TG67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG67", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG67-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA50", "url": "https://www.uniprot.org/uniprotkb/E1BA50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA50-1", "url": "https://www.uniprot.org/uniprotkb/E1BA50-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDFVLRNEMWLLILVAHLFQRNVNSGHMRTTTVDPEAFMNISEIIQHKRYPCEEYEVLTEDGYILSVNRIPQGLVQLKKTGPRPVVLLQHGLLGDASNWISNLPNNSLGFILADAGFDVWLGNSRGNTWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTGQEKIYYVGYSQGTTMGFIAFSTMPELAQKIKMYFALAPIATIKYAKSPGTKFLLLPDMMIKGLFGKREFLYQTRFLRQFVVYLCSQVIMDQICSNIMLLLGGFNPKNMNMSRANVYVAHTPSGTSVQNILHWSQAANSGELRAFDWGSETKNLEKGNQPTPVRYKVRDMTVPTAIWTGGQDWLSNPDDVRTLLSEVTNLIYHKNIPEWAHVDFIWGLDAPHRMYNEIIHLMKQEDTSLSQGTISVSL", "length": 415, "header": "tr|E1BA50-1|E1BA50_BOVIN Isoform 1 of Lipase OS=Bos taurus OX=9913 GN=LIPM PE=3 SV=3 CANONICAL=E1BA50-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TG67-1", "url": "https://www.uniprot.org/uniprotkb/E1BA50/entry#A0AAA9TG67-1", "sequence": { "sequence": "MPKILSREWIVSYRNEMWLLILVAHLFQRNVNSGHMRTTTVDPEAFMNISEIIQHKRYPCEEYEVLTEDGYILSVNRIPQGLVQLKKTGPRPVVLLQHGLLGDASNWISNLPNNSLGFILADAGFDVWLGNSRGNTWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTGQEKIYYVGYSQGTTMGFIAFSTMPELAQKIKMYFALAPIATIKYAKSPGTKFLLLPDMMIKGLFGKREFLYQTRFLRQFVVYLCSQVIMDQICSNIMLLLGGFNPKNMNMAANSGELRAFDWGSETKNLEKGNQPTPVRYKVRDMTVPTAIWTGGQDWLSNPDDVRTLLSEVTNLIYHKNIPEWAHVDFIWGLDAPHRMYNEIIHLMKQEDTSLSQGTISVSL", "length": 399, "header": "tr|A0AAA9TG67-1|E1BA50_BOVIN Computationally mapped isoform of Lipase OS=Bos taurus OX=9913 GN=LIPM PE=3 SV=1 CANONICAL=E1BA50-1" }, "locus": { "chromosome": "26", "start_pos": 10505103, "end_pos": 10485267, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098419.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098419.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097171.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097171.1" } ] } }, { "isoform_ac": "E1BA50-1", "url": "https://www.uniprot.org/uniprotkb/E1BA50/entry#E1BA50-1", "sequence": { "sequence": "MDFVLRNEMWLLILVAHLFQRNVNSGHMRTTTVDPEAFMNISEIIQHKRYPCEEYEVLTEDGYILSVNRIPQGLVQLKKTGPRPVVLLQHGLLGDASNWISNLPNNSLGFILADAGFDVWLGNSRGNTWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTGQEKIYYVGYSQGTTMGFIAFSTMPELAQKIKMYFALAPIATIKYAKSPGTKFLLLPDMMIKGLFGKREFLYQTRFLRQFVVYLCSQVIMDQICSNIMLLLGGFNPKNMNMSRANVYVAHTPSGTSVQNILHWSQAANSGELRAFDWGSETKNLEKGNQPTPVRYKVRDMTVPTAIWTGGQDWLSNPDDVRTLLSEVTNLIYHKNIPEWAHVDFIWGLDAPHRMYNEIIHLMKQEDTSLSQGTISVSL", "length": 415, "header": "tr|E1BA50-1|E1BA50_BOVIN Isoform 1 of Lipase OS=Bos taurus OX=9913 GN=LIPM PE=3 SV=3 CANONICAL=E1BA50-1" }, "locus": { "chromosome": "26", "start_pos": 10505103, "end_pos": 10469666, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017778.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017778.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017778.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017778.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6809371", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "resource": "Reactome", "description": "Formation of the cornified envelope" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061I960-1", "protein_name": "Lipase", "gene_name": "LOC100761952", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSEILSRAWSVSHRVEIWLLILLAYLLQRNVNSGHMPTKAADPEAFMNVSEIIKHKGYPSEEYEVATEDGYILSVNRIPQGLTQLKKEGSRPVVLLQHGLLGDASNWISNLPNNSLGFILADAGFDVWMGNSRGNTWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTGQKKIYYVGYSQGTTMGFIAFSTMPELAHKIKMYFALAPIATVKYARSPGTKFLLLPDMMIKGLFGRQEFLYQTRFFRQLFIYLCGQMILDQICSNIILLLGGFNTNNMNMSRANVYVAHTPAGTSVQNILHWSQAVNSGELRAFDWGSETKNLEKCNQPTPIRYKVRDMTVPTAMWTGGQDWLSNPDDVKTLLSEVSNLIYHKNIPEWAHVDFIWGLDAPHRVYNEIIHLMKLEPNLSQGTCKVTL", "length": 422 }, "evidence": [ { "id": "E1BA50", "url": "https://omabrowser.org/oma/group/E1BA50/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A4X1V5I0-1", "protein_name": "Lipase", "gene_name": "LIPM", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSKILSREWIVSYRNEMWLLILVAYLFQRNVNSGHMPTIAVDPEAFMNISEIIQHKGYPCEEYEVATEDGYILSVNRIPQGLVQHKKTGPRPVVLLQHGLFGAASNWISNLPNNSLGFILADAGFDVWMGNSRGNTWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTGQEKIYYVGYSQGTTIGFIAFSTMPELAQKIKTYFALAPIATIKYAKSPGAKFLLLPDMMIKGLFGKKEFLYQTRFLRQFVIYLCGQVVLDQICSNIMLLLGGFNANNMNMSRVNVYVAHTPAGTSVQNILHWSQAVNSGELRAFDWGSETKNLEKSNQPTPVRYKVRDMTVPTAMWTGGQDWLSNPEDVRTLLSEVTHLIYHKNIPEWAHADFIWGLDAPHRMYNEIIHLMKQEETSLSQGTFGVSL", "length": 423 }, "evidence": [ { "id": "E1BA50", "url": "https://omabrowser.org/oma/group/E1BA50/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4AA61-1", "protein_name": "Lipase", "gene_name": "Lipm", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSEILSRAWSVSHRVEIWLLILVAYLLQRNVNSGHMPTKAADPEAFMNVSEIIKHKGYPSEEYEVATEDGYILSVNRIPRGQTQLKKEGSRPVVLLQHGLLGDASNWISNLPNNSLGFILADAGFDVWMGNSRGNTWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTGQKKIYYVGYSQGTTMGFIAFSTMPELAHKIKMYFALAPIATVKHAKSPGTKFLLLPDMMIKGLFGRQEFLYQTRFFRQLFIYLCGQMILDQICSNIILLLGGFNTNNMNMSRANVYVAHTPAGTSVQNILHWSQAVNSGELRAFDWGSETKNREKSNQPTPIRYKVRDMMVPTAMWTGGQDWLSNPDDVKTLLSEVTNLIYHKNIPEWAHVDFIWGLDAPHRVYNEIIHLMKQESSLPQGTCRVKL", "length": 422 }, "evidence": [ { "id": "E1BA50", "url": "https://omabrowser.org/oma/group/E1BA50/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5VYY2-1", "protein_name": "Lipase member M", "gene_name": "LIPM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLETLSRQWIVSHRMEMWLLILVAYMFQRNVNSVHMPTKAVDPEAFMNISEIIQHQGYPCEEYEVATEDGYILSVNRIPRGLVQPKKTGSRPVVLLQHGLVGGASNWISNLPNNSLGFILADAGFDVWMGNSRGNAWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTGQEKIYYVGYSQGTTMGFIAFSTMPELAQKIKMYFALAPIATVKHAKSPGTKFLLLPDMMIKGLFGKKEFLYQTRFLRQLVIYLCGQVILDQICSNIMLLLGGFNTNNMNMSRASVYAAHTLAGTSVQNILHWSQAVNSGELRAFDWGSETKNLEKCNQPTPVRYRVRDMTVPTAMWTGGQDWLSNPEDVKMLLSEVTNLIYHKNIPEWAHVDFIWGLDAPHRMYNEIIHLMQQEETNLSQGRCEAVL", "length": 423 }, "evidence": [ { "id": "E1BA50", "url": "https://omabrowser.org/oma/group/E1BA50/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q75JK5-1", "protein_name": "Lipase", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKLNYLISILLFLIINYSSFVSSINIFKDINIIYDHLKDDIKEIIVDATTTVNHVEYFIDIVNSNGYPCEHHSVITEDGYILGVFRIPYSYNNNQNLNNKTRQPILLQHGLLDSSITWIVNNANQSLPFILSDMGYDVWMGNNRGNTFSINHTRLDVKSREFWEFSFDDMGWYDLPSMVDYIIQVSGVDEIGYVGHSEGTMQAWISYSEIKGFDKKVPIYMGLGPVGNVSHITNVALKTMATFRIDDLFRIFGTKQFLPSPKLLRGIFISFCIDCPLCCEDVVEWLCGPHKGAFNQSRMPFVSGNEPGGTSLRNMVHFTQLVNSKQFQHYDYGVIGNLLHYGHEKPPLINVENIPPTVKIALFSGTKDELADTIDVKQLVSLLPPETILSWDIIENYAHLDFVWAIDANILVYPKILNFFNNFFNQSKS", "length": 429 }, "evidence": [ { "id": "E1BA50", "url": "https://omabrowser.org/oma/group/E1BA50/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8K2A6-1", "protein_name": "Lipase member M", "gene_name": "Lipm", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSEILSRVWTVSHRVEIWLLILVAYLLQRNVNSGHLPTKAADPEAFMNVSEIIKHKGYPSEEYEVATEDGYILSVNRIPRGQTRLKKEGSRPVVLLQHGLLGDASNWISNLPNNSLGFILADAGFDVWMGNSRGNTWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTGQKKVYYVGYSQGTTMGFIAFSTMPELAHKIKMYFALAPIATVKYARSPGTKFLLLPDMMIKVLFGRQEFLYQTRFFRQLFIYLCGQMILDQICSNIILLLGGFNTNNMNMSRANVYVAHTPAGTSVQNILHWSQAVNSGELRAFDWGSETKNQEKCNQPTPIRYKVRDMMVPTAMWTGGQDWLSNPDDVKTLLSEVTNLIYHKNIPEWAHVDFIWGLDAPQRVYNEIIHLMKQEPNLPQGTCRVKL", "length": 422 }, "evidence": [ { "id": "E1BA50", "url": "https://omabrowser.org/oma/group/E1BA50/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "E1BA50", "url": "https://www.uniprot.org/uniprotkb/E1BA50" } ], "pmid": "" }, { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "E1BA50", "url": "https://www.uniprot.org/uniprotkb/E1BA50" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "triacylglycerol lipase activity", "id": "GO:0004806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004806", "evidence": [ { "database": "UniProtKB", "id": "E1BA50", "url": "https://www.uniprot.org/uniprotkb/E1BA50" } ], "pmid": "" }, { "name": "lipase activity", "id": "GO:0016298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016298", "evidence": [ { "database": "UniProtKB", "id": "E1BA50", "url": "https://www.uniprot.org/uniprotkb/E1BA50" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 105, "end_pos": 107, "annotation": "n_glycosylation_sequon" }, { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12044", "name": "", "equation": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A5PK46-1", "A0A3Q1LV96-1", "A0A3Q1MLE6-1", "Q3SZ79-1", "E1BJQ9-1", "Q5EA42-1", "P11151-1", "P16386-1", "P30122-1", "Q29458-1", "Q2KI18-1", "F1MC21-1", "Q0P5B7-1", "A0A3Q1M7B8-1", "F6RA94-1", "G5E5T0-1", "A0A3Q1LR40-1", "A0AAA9S3G3-1", "A0ABI0NMZ2-1" ], "evidence": [ { "id": "12044", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12044" } ] }, { "id": "39931", "name": "", "equation": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29458-1" ], "evidence": [ { "id": "39931", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39931" } ] }, { "id": "40047", "name": "", "equation": "1,2,3-trioctanoylglycerol + H2O = 1,2-dioctanoyl-sn-glycerol + octanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29458-1" ], "evidence": [ { "id": "40047", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40047" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LR40", "gene_name": "LIPG", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LR40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR40" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LR40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR40" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "A0A3Q1LR40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR40" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "A0A3Q1LR40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR40" } ] } ] }, { "uniprot_ac": "A0A3Q1LV96", "gene_name": "PLB1", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] } ] }, { "uniprot_ac": "A0A3Q1M7B8", "gene_name": "PNLIPRP1", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1M7B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7B8" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "A0A3Q1M7B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7B8" } ] } ] }, { "uniprot_ac": "A0A3Q1MLE6", "gene_name": "LIPE", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "A0A3Q1MLE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLE6" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = glycerol + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1MLE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLE6" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "A0A3Q1MLE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLE6" } ] }, { "ec_number": "3.1.1.79", "activity": "", "evidence": [ { "id": "A0A3Q1MLE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLE6" } ] } ] }, { "uniprot_ac": "A0AAA9S3G3", "gene_name": "LOC100297709", "activity": [ { "ec_number": "2.3.1.51", "activity": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA.", "evidence": [ { "id": "A0AAA9S3G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3G3" } ] }, { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0AAA9S3G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3G3" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "A0AAA9S3G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3G3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "A0AAA9S3G3", "database": 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"database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B9K5", "url": "https://www.orthodb.org/?gene=E1B9K5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21292", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21292", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21292:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21292:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TIK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9K5", "url": "https://www.uniprot.org/uniprotkb/E1B9K5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9K5-1", "url": "https://www.uniprot.org/uniprotkb/E1B9K5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAERGSAAAKMPLPQTEASGPEPHRPQEPAEPHTPAQGARRASSEDAPGAGHEGSRPGLGTLRRAFSRASQRASVRAPRGDARLLRLSGRFLFGSLRRTPDNGPAGDQTGSTSEPGPACGRKGSSKAKEGVSRRSSTREGPAEAEGTSVADLISERQLLAAFEQLRHLETGLVAEKASCTFQQDPTGFARRAMDVCLHYDGLAAEIGAIVRETLGPDGVDAAALEELARVVRAEEEAHPEPPADGDFLRTPRRWRQYWEDAVRRSAEERVRQAGAGEAPGAADAAPDLARLLAELGALVRRDLQKVQREVHPAYAAAGFPAWEAYLRAFHGAVARRLQELAHDARGCEQLYVLLDWVANVYSSPDFLGSQDQALPSEPLPPLLAPEVWARLEDDYTSFLETKISSCFDGILQLEQSRWAAADAPDVLQGLYHTSLSFDVCMLVAEHVKAAGAISAELEATTLGICARALGLFLQKYEKAFLESGAVSEPNLCASINACQELRTHLLAKFPESFGELEKALGAAARAFQKQLLQGLQSAVQPLFRVLCTKAWLTQDLLQPLMDKVVAFSGLLEHMAPPLAQETLQEVHRYVVREYLEQALRPRERLRGADRRSGSQKMGLEAQAISSTFQGLGSEATWLGQAIPCVADILGETYKDDIGRHLETLIKSYPDIRRDHVLAILALRRLGRRRNQHFLRHAQALLRAAAKAGGSGAAGGRVLFEEIELSTSIDVLVTCI", "length": 735, "header": "tr|E1B9K5-1|E1B9K5_BOVIN Isoform 1 of Exocyst complex component 3-like protein 4 OS=Bos taurus OX=9913 GN=EXOC3L4 PE=3 SV=4 CANONICAL=E1B9K5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TIK5-1", "url": "https://www.uniprot.org/uniprotkb/E1B9K5/entry#A0AAA9TIK5-1", "sequence": { "sequence": "MPLPQTEASGPEPHRPQEPAEPHTPAQGARRASSEDAPGAGHEGSRPGLGTLRRAFSRASQRASVRAPRGDARLLRLSGRFLFGSLRRTPDNGPAGDQTGSTSEPGPACGRKGSSKAKEGVSRRSSTREGPAEAEGTSVADLISERQLLAAFEQLRHLETGLVAEKASCTFQQDPTGFARRAMDVCLHYDGLAAEIGAIVRETLGPDGVDAAALEELARVVRAEEEAHPEPPADGDFLRTPRRWRQYWEDAVRRSAEERVRQAGAGEAPGAADAAPDLARLLAELGALVRRDLQKVQREVHPAYAAAGFPAWEAYLRAFHGAVARRLQELAHDARGCEQLYVLLDWVANVYSSPDFLGSQDQALPSEPLPPLLAPEVWARLEDDYTSFLETKISSCFDGILQLEQSRWAAADAPDVLQGLYHTSLSFDVCMLVAEHVKAAGAISAELEATTLGICARALGLFLQKYEKAFLESGAVSEPNLCASINACQELRTHLLAKFPESFGELEKALGAAARAFQKQLLQGLQSAVQPLFRVLCTKAWLTQDLLQPLMDKVVAFSGLLEHMAPPLAQETLQEVHRYVVREYLEQALRPRERLRGADRRSGSQKMGLEAQAISSTFQGLGSEATWLGQAIPCVADILGETYKDDIGRHLETLIKSYPDIRRDHVLAILALRRLGRRRNQHFLRHAQALLRAAAKAGGSGAAGGRVLFEEIELSTSIDVLVTCI", "length": 725, "header": "tr|A0AAA9TIK5-1|E1B9K5_BOVIN Computationally mapped isoform of Exocyst complex component 3-like protein 4 OS=Bos taurus OX=9913 GN=EXOC3L4 PE=3 SV=1 CANONICAL=E1B9K5-1" }, "locus": { "chromosome": "21", "start_pos": 67772532, "end_pos": 67763709, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093006.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093006.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096738.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096738.1" } ] } }, { "isoform_ac": "E1B9K5-1", "url": "https://www.uniprot.org/uniprotkb/E1B9K5/entry#E1B9K5-1", "sequence": { "sequence": "MAERGSAAAKMPLPQTEASGPEPHRPQEPAEPHTPAQGARRASSEDAPGAGHEGSRPGLGTLRRAFSRASQRASVRAPRGDARLLRLSGRFLFGSLRRTPDNGPAGDQTGSTSEPGPACGRKGSSKAKEGVSRRSSTREGPAEAEGTSVADLISERQLLAAFEQLRHLETGLVAEKASCTFQQDPTGFARRAMDVCLHYDGLAAEIGAIVRETLGPDGVDAAALEELARVVRAEEEAHPEPPADGDFLRTPRRWRQYWEDAVRRSAEERVRQAGAGEAPGAADAAPDLARLLAELGALVRRDLQKVQREVHPAYAAAGFPAWEAYLRAFHGAVARRLQELAHDARGCEQLYVLLDWVANVYSSPDFLGSQDQALPSEPLPPLLAPEVWARLEDDYTSFLETKISSCFDGILQLEQSRWAAADAPDVLQGLYHTSLSFDVCMLVAEHVKAAGAISAELEATTLGICARALGLFLQKYEKAFLESGAVSEPNLCASINACQELRTHLLAKFPESFGELEKALGAAARAFQKQLLQGLQSAVQPLFRVLCTKAWLTQDLLQPLMDKVVAFSGLLEHMAPPLAQETLQEVHRYVVREYLEQALRPRERLRGADRRSGSQKMGLEAQAISSTFQGLGSEATWLGQAIPCVADILGETYKDDIGRHLETLIKSYPDIRRDHVLAILALRRLGRRRNQHFLRHAQALLRAAAKAGGSGAAGGRVLFEEIELSTSIDVLVTCI", "length": 735, "header": "tr|E1B9K5-1|E1B9K5_BOVIN Isoform 1 of Exocyst complex component 3-like protein 4 OS=Bos taurus OX=9913 GN=EXOC3L4 PE=3 SV=4 CANONICAL=E1B9K5-1" }, "locus": { "chromosome": "21", "start_pos": 67772532, "end_pos": 67763151, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038474.6", "url": "https://www.ensembl.org/id/ENSBTAT00000038474.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038287.6", "url": "https://www.ensembl.org/id/ENSBTAP00000038287.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:526547", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526547", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YT99-1", "protein_name": "Exocyst complex component 3 like 4", "gene_name": "EXOC3L4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSTNTKVYLRRSASEPDPATNVVEKEKMEVAPELGSPTSNDESTGFIERGMKTMLSIRKSKRKNEKEQEGTGTWRRRLLSFQFPKSSEENKTKILDGLEEIVDKAETEPTEGKPLSVMEINDLIQKKQLLEAFASIKYLEDETIAERDADKYKDNPQEFLRKTKDVDLLYTSITSMIQSIVVGTLEHHTVEESTLTSLVTLIAREEAAHPNTGTAADPGSDLLGSPRKWREKWREAVNEGTRKRVLSIPMASTEEEKAWLDLHLSFLQKHLLEDLLKIKSSVKKCYPEEYRVCEVYVEAFHNAIASHLQDLSQRPLEFNELYSLLDWVVNTYHSSMELDGQLFGQECCGNNACRSWGKNELFLGHSDLKPEVQTENLSLLLTTADWDRLNDDYITSVKGKIKSYFGNILTLEVTEKWEKEVPPEVKDNLYQSSLSLDIQTIIGEHMKLSEAISKKLKRKTLELCLAELHEFIPRFGEKFLEWNEVHDSPMFAPYFAAYINSFHDLLSGLETVFQVNTEELQKILAALTRNFRNVFLNKLRTKTQPLLKKILTKDWILAREKPNSLAVAVSQFSEHLQHTRQPLGQELLCHVHKYVVREYIVQIIKPKKKMNGEKRQQVSERIKQEVKILNNALIDHGSDSSWLLPAISHIANIIGEKRKDRIKEYVKELTQDYPDIRKEHIMAILTVRGLGFTSRRMIFQQGFHHALESPDGEDGNTLFAEIDVPAVVSCF", "length": 731 }, "evidence": [ { "id": "E1B9K5", "url": "https://omabrowser.org/oma/group/E1B9K5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0AC58H1A7-1", "protein_name": "Exocyst complex component 3-like protein 4 isoform X1", "gene_name": "exoc3l4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MYGHVGQKCHSKTIIPRRTVFGLIQLTFAIMAETVKEEVDEANEVNDLPEWHEDAKESLKNGGEHMESPVKQKSTGLMKSFRASLKKVASPMKNKKPENTNNGQSQISNAQLQPLHSPSLITGSPGQSSFRSPRTEKPPLTRTMSDSDVITLQKKGSSIRRSLGLSKKPKQEPLVTVTEAMPLSEEPKPEVADECEGQMVLELRDTYVLPEIPAMPLSVMEINKLIEMEVLEEAYVNLLSLRLELQQQRKSQNQEDCPIELVHKEKDLSLLYGTLRNKMSDIVRNSSTLPSRNKELLVYVAYIILEEEKRQDEPGAMQGWRESWRVAVRDGVRDTLKRVHLDTREQNISWLAVHLGLLGKAILEDLERVKTELVSSYPPEFNVFETYVSCHHEAVGEHLKTLLEKVTELKDYYALLDFIIHRYPSEKIMGSTSLQPEVKEDNRALPLDNDFLNQIKMKYCSRLQVDMRTSLDRVIELENEEIWKERRKPEIDEGIYSSHIDMDIWTNIKGHVQGSRRIDVTLEKEVVRSCLDELKSFPKRFESAFVESCRVFSNSSLWAEYHISYINSFSDLKEHMEGYKQSCQIQLEQVRKEIDGLTTRLRQTLMEQFKTDVKPFLRRQMTGKWFSFDEDFSQLATRIKSLSEQSKYMSPKYRQAFVNEVHFFVVKEYVSQLMKNNYSCKNRKNETAAAKITKQWEELKEIFQDMHSTLDWLHSVGNHLSQIIGCKKSDVKHNLKPLVENYPDIRRSHLSAVLYFRGIIRGREKHVILQRLAELKQSLGSSGNKEQALFSEIQASANTDCLAGTPFSCLSFIMPDR", "length": 817 }, "evidence": [ { "id": "E1B9K5", "url": "https://omabrowser.org/oma/group/E1B9K5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q17RC7-1", "protein_name": "Exocyst complex component 3-like protein 4", "gene_name": "EXOC3L4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPSPQTDTPGPELQSPKEAEEPQTPAQGSRRTSSRKEPNAHRKDGTRLGLGSLRQAFSRASQRALTQVSKEDTGLFRRSSCSLFRSFRQALNDGPATGHSQATPEVPSGVMNGVSQQASTGAASEELKPEAEGKSVADLITERQLLAAFEQLLRLETLLVAEKASRTFEQDPTAFARRAMDVCLLYDGLAAEIGAIVRETLDSDGVDAAALAELARVVSAEEEAHPSPPDDGDFLRTPRRWRQHWEEAVRRSAQERVRRPGAGWAFGEAEGASGLAQLLAELGGLVRRDLQKVRQEVQPAYAAAGFPAWEVYLRAFHSAVAQRLQELARDARGCEQLYILLDWAANVYGSPDFLGAPGLALPAEPLPPLLAPDVWARLESDYTSFLEAKIASCFDSILQLEQSHWAAAEVPEVLQGLYQAPLSMDVHMLVAEHVKAAGAISAELEATTLRICTRALGLFVPRFEKAFLASEAVSEPHLGAYINACEELRTSLLSRFPGTQEELEKPLVTATCSFQKHLLQGLQRELQPLFRVVCTRDWLTQDWLHPLMDKVVTFAGHLQRVARPRAQETLQEVHRFVVREYLARALRPRERFRGMERMHGSQKMSLDAQAISDTFQGLGSEATWLDQAIQCVAEILGETYKDDIQRHLETLIRSYPDIRRDHILAILALRRLGRQRNQHLLQHTQDLLRAAAGAAGAEAPRGRVLFEEIKVPSAMAVLITCV", "length": 722 }, "evidence": [ { "id": "E1B9K5", "url": "https://omabrowser.org/oma/group/E1B9K5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6DIA2-1", "protein_name": "Exocyst complex component 3-like protein 4", "gene_name": "Exoc3l4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPLPQTGAPGPEVKSPREPRKSQTLPVTTWKSNSMKEQSVHHGGSLRPSLGMLKQTLFRTSLRTSTHKPKEDPGLFRRSSRFLFRSLRRAIDEGLTAGHPQGPAVPEKPSKVTDGVSRQAATGTEAEDLEPQAESKSVADLITERQLVKAFEQLRYLETQLVADKTSRTFTQDPTAYARRAMDLCLHYDGMAAEIGAIVREALSSEGVDRDALAELAQVVHLEEEAHQTSQAEGDFLSTPRHWRMHWEDAVRLSAQESVQQAGAKVIPGAAEGSSDLAQLLAELGGVVRHDLQKVRLEMQPAYEATDFPVWETYLRAFHSAVAQRLQELARDARGCEQLYVLLDWAANVYGSPDFLGAPDLALPTEPLPPLLEPALWARLESDYTSFLETKITSCFDSILQLEQNRWEADEDREVLQGLYHAPLSIDVHMLVAEHVKAAGAISAELEATTLQICARALCLFVPRFEKAFLASKAVSEWYLGAYINACVELRTSLLARFPGTIKELEKPLVAATNSFQKHLLQIVQQDMQPLFKVLYTKSWLTQDTLRPLMDKVVDFAHHLEHVTPPLAQETLQEVHRFVVREYLGQVLRPHERFSGQDRLKGSNKMNLDAQAISNTFQGLGSEAKWLDQAILSVAEILGETYKDDIRRHLETLIRSYPDIRRDHILAILALRRLGRRRNQNLLQHTQDLLRAAHETRLPSHHVLFEEIEVPTSVDVLITCI", "length": 721 }, "evidence": [ { "id": "E1B9K5", "url": "https://omabrowser.org/oma/group/E1B9K5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "E1B9K5", "url": "https://www.uniprot.org/uniprotkb/E1B9K5" } ], "pmid": "" }, { "name": "exocyst localization", "id": "GO:0051601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051601", "evidence": [ { "database": "UniProtKB", "id": "E1B9K5", "url": "https://www.uniprot.org/uniprotkb/E1B9K5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "exocyst", "id": "GO:0000145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000145", "evidence": [ { "database": "UniProtKB", "id": "E1B9K5", "url": "https://www.uniprot.org/uniprotkb/E1B9K5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "SNARE binding", "id": "GO:0000149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000149", "evidence": [ { "database": "UniProtKB", "id": "E1B9K5", "url": "https://www.uniprot.org/uniprotkb/E1B9K5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B9K5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 735, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B9K5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B9K5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B982-1", "uniprot_ac": "E1B982", "uniprot_id": "E1B982_BOVIN", "mass": { "chemical_mass": 91971.0, "monoisotopic_mass": 91971.0 }, "refseq": { "ac": "XP_059737672", "name": "polyserase-2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737672" }, "gene_names": [ { "name": "PRSS36", "type": "recommended", "evidence": [ { "id": "E1B982", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B982" } ] }, { "name": "PRSS36", "type": "synonym", "evidence": [ { "id": "XP_059737672", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737672" } ] } ], "protein_names": [ { "name": "Polyserase-2", "type": "recommended", "evidence": [ { "id": "E1B982", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B982/entry#names_and_taxonomy" } ] }, { "name": "3.4.21.-", "type": "synonym", "evidence": [ { "id": "E1B982", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B982/entry#names_and_taxonomy" } ] }, { "name": "polyserase-2", "type": "synonym", "evidence": [ { "id": "XP_059737672", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737672" } ] } ], "function": [ { "annotation": "Serine protease. 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OS=Bos taurus OX=9913 GN=PRSS36 PE=4 SV=1 CANONICAL=E1B982-1" }, "locus": { "chromosome": "25", "start_pos": 27244909, "end_pos": 27236566, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127349.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127349.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096910.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096910.1" } ] } }, { "isoform_ac": "E1B982-1", "url": "https://www.uniprot.org/uniprotkb/E1B982/entry#E1B982-1", "sequence": { "sequence": 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Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.", "evidence": [ { "database": "UniProtKB", "id": "E1B847", "url": "https://www.uniprot.org/uniprotkb/E1B847#function" }, { "database": "UniProtKB", "id": "ARBA00054158", "url": "https://www.uniprot.org/uniprotkb/ARBA00054158#function" }, { "database": "UniProtKB", "id": "A0AAA9TKL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKL4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B847", "url": "https://www.uniprot.org/uniprotkb/E1B847" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAP3K1", "url": "https://www.uniprot.org/uniprotkb/E1B847", "locus": { "chromosome": "20", "start_pos": 22340163, "end_pos": 22417627, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013790", "url": "https://www.ensembl.org/id/ENSBTAG00000013790" } ] } } ], "crossref": [ { "id": "ENSBTAG00000013790", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013790", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06630", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06630", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16494", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16494", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523962", "url": "https://www.ncbi.nlm.nih.gov/gene/523962", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050538", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050538", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523962", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523962", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CHSQTIF", "url": "https://omabrowser.org/oma/group/CHSQTIF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B847", "url": "https://www.orthodb.org/?gene=E1B847", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48016", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48016", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04434", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04434", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF28295", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28295", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-166058", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2871796", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2871796", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975138", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975138", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975871", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975871", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192835", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TKL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKL4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B847", "url": "https://www.uniprot.org/uniprotkb/E1B847", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B847-1", "url": "https://www.uniprot.org/uniprotkb/E1B847-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAAGNRASSSGFPGAGAASPEAGGGRGALKASSAPAAAAGLLREAGSGGRERADWRRRQLRKVRSVELDQLPEPPLFLAASPPSSSTSPSPEPPDAAAGGSGFQPVAVPPPHGAASRGGAHPAEPAAAPDSGAQSPAGAEPGEKRTPAAEPTAAAPAGREMENKETLKGLHKMDDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPIKGDGSEINNLAAESQGEGPTSAASSTPKGRRSPSPGSSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCGRGTFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVDSPSPLRAPQQQTTQQHALAGSQRRNQEGSLTLTHYGTQQIPPSYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGSSSGSGPGAGATSGSSQTSISGDVVEACCNVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLRPVVDTILVKCADVNSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDISQAEPVEVRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTAVPHVFSKLLEMLNVSSSTHFTRMRRRLMAIADEVEIAEAIQLGVEDTLDGRHDCFLQASAPNSYPEAMDNSSFERMDHLEKPGKGLCATKLSASSEDISDRLASISVGLPNSTTMEQPKPMVQTKGRPHSQCLNASPASPHSQLMFPALSTPSSSTPSVPSGTGTDLSKQRPQGFVPCKMPSASPQTQRKFSLQFQRNCSENKDSDKLSPIFTQSRPLPSSNIHRPKPSRPTPSNTSKQGDASKNSMTLDLNSRSKCDDSFGSSSNSSNAVIPSDETVFTPVEEKCRLDVSTELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKDENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPVVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDSEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTTW", "length": 1507, "header": "tr|E1B847-1|E1B847_BOVIN Isoform 1 of Mitogen-activated protein kinase kinase kinase 1 OS=Bos taurus OX=9913 GN=MAP3K1 PE=3 SV=2 CANONICAL=E1B847-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TKL4-1", "url": "https://www.uniprot.org/uniprotkb/E1B847/entry#A0AAA9TKL4-1", "sequence": { "sequence": "MSPVVVMGETVTCILLAAGVLDSAPQPGDYFGISPVSLGCETSLVSPWILGSRMVSCLVQLKQGEFLSMDHFRCPSELLLLNKACSEGCLSVVVSRREMENKETLKGLHKMDDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPIKGDGSEINNLAAESQGEGPTSAASSTPKGRRSPSPGSSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCGRGTFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVDSPSPLRAPQQQTTQQHALAGSQRRNQEGSLTLTHYGTQQIPPSYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGSSSGSGPGAGATSGSSQTSISGDVVEACCNVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLRPVVDTILVKCADVNSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDISQAEPVEVRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTAVPHVFSKLLEMLNVSSSTHFTRMRRRLMAIADEVEIAEAIQLGVEDTLDGRHDCFLQASAPNSYPEAMDNSSFERMDHLEKPGKGLCATKLSASSEDISDRLASISVGLPNSTTMEQPKPMVQTKGRPHSQCLNASPASPHSQLMFPALSTPSSSTPSVPSGTGTDLSKQRPQGFVPCKMPSASPQTQRKFSLQFQRNCSENKDSDKLSPIFTQSRPLPSSNIHRPKPSRPTPSNTSKQGDASKNSMTLDLNSRSKCDDSFGSSSNSSNAVIPSDETVFTPVEEKCRLDVSTELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKDENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPVVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDSEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTTW", "length": 1443, "header": "tr|A0AAA9TKL4-1|E1B847_BOVIN Computationally mapped isoform of Mitogen-activated protein kinase kinase kinase 1 OS=Bos taurus OX=9913 GN=MAP3K1 PE=3 SV=1 CANONICAL=E1B847-1" }, "locus": { "chromosome": "20", "start_pos": 22399249, "end_pos": 22342584, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097816.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097816.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096807.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096807.1" } ] } }, { "isoform_ac": "E1B847-1", "url": "https://www.uniprot.org/uniprotkb/E1B847/entry#E1B847-1", "sequence": { "sequence": "MAAAAGNRASSSGFPGAGAASPEAGGGRGALKASSAPAAAAGLLREAGSGGRERADWRRRQLRKVRSVELDQLPEPPLFLAASPPSSSTSPSPEPPDAAAGGSGFQPVAVPPPHGAASRGGAHPAEPAAAPDSGAQSPAGAEPGEKRTPAAEPTAAAPAGREMENKETLKGLHKMDDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPIKGDGSEINNLAAESQGEGPTSAASSTPKGRRSPSPGSSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCGRGTFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVDSPSPLRAPQQQTTQQHALAGSQRRNQEGSLTLTHYGTQQIPPSYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGSSSGSGPGAGATSGSSQTSISGDVVEACCNVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLRPVVDTILVKCADVNSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDISQAEPVEVRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTAVPHVFSKLLEMLNVSSSTHFTRMRRRLMAIADEVEIAEAIQLGVEDTLDGRHDCFLQASAPNSYPEAMDNSSFERMDHLEKPGKGLCATKLSASSEDISDRLASISVGLPNSTTMEQPKPMVQTKGRPHSQCLNASPASPHSQLMFPALSTPSSSTPSVPSGTGTDLSKQRPQGFVPCKMPSASPQTQRKFSLQFQRNCSENKDSDKLSPIFTQSRPLPSSNIHRPKPSRPTPSNTSKQGDASKNSMTLDLNSRSKCDDSFGSSSNSSNAVIPSDETVFTPVEEKCRLDVSTELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKDENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPVVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDSEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTTW", "length": 1507, "header": "tr|E1B847-1|E1B847_BOVIN Isoform 1 of Mitogen-activated protein kinase kinase kinase 1 OS=Bos taurus OX=9913 GN=MAP3K1 PE=3 SV=2 CANONICAL=E1B847-1" }, "locus": { "chromosome": "20", "start_pos": 22417428, "end_pos": 22342584, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018325.5", "url": "https://www.ensembl.org/id/ENSBTAT00000018325.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018325.4", "url": "https://www.ensembl.org/id/ENSBTAP00000018325.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1061, "start_aa": "Thr", "end_pos": 1061, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1061", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 154, "start_aa": "Thr", "end_pos": 154, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr154", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 237, "start_aa": "Thr", "end_pos": 237, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr237", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 980, "start_aa": "Thr", "end_pos": 980, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr980", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 985, "start_aa": "Thr", "end_pos": 985, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr985", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:523962", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523962", "resource": "KEGG Pathway" }, { "id": "R-BTA-166058", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-166058", "resource": "Reactome", "description": "MyD88:MAL(TIRAP) cascade initiated on plasma membrane" }, { "id": "R-BTA-2871796", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2871796", "resource": "Reactome", "description": "FCERI mediated MAPK activation" }, { "id": "R-BTA-975138", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975138", "resource": "Reactome", "description": "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation" }, { "id": "R-BTA-975871", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975871", "resource": "Reactome", "description": "MyD88 cascade initiated on plasma membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287ABQ5-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 1", "gene_name": "MAP3K1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAAAGNRASSSGFPGAGAASPEAGGGGGALKAGSAPAAAAGLLREAGSGGRERADWRRRQLRKVRSVELDQLPEPPLFLAASPPSSSTSPSPEPADAPASGSSFQPVAVPPPHGAGSRGGAHPAEPAAAPDSGAPSTAGAEPGEKRMPAAEPPSTAAPVGREMENKETLKGLHKMDDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPIKGDGSEINNLAAESQGDGQASVASPAPKGRRSPSPGSSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETSRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCGRGTFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVDSPSSLRAAQQQTTQQHPLAGSQRRNQESNFNLTHYGTQQIPPAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGHSGSNGGSSPSAGATSGSSQTSISGDVVEACCNILSMVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLRPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEVRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTAVPHVFSKLLEMLNVSSSTHFTRMRRRLMAIADEVEIAEAIQLGIDETLDGRHDSFLQAPVPNNYPEATENSSLERTDHLEKTGKGLCATKLSASSEDISDRLASISVGLPSSATMEQPKPMVQTKGRPHSQCLNSSPLSHHSQLMFPALSTPTSSVPSVPAGTVTDVSKHRPQGFVPCKIPSASPQTQRKFSLQFQRNCSENKDSDKLSPIFTQSRPLPSSNIHRPKPSRPAPSNTSKQGDASKNSMTLDLNSSSKCDDSFGSSSNGSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKDENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTTW", "length": 1508 }, "evidence": [ { "id": "E1B847", "url": "https://omabrowser.org/oma/group/E1B847/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P53349-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 1", "gene_name": "Map3k1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAAGDRASSSGFPGAAAASPEAGGGGGGGGALQGSGAPAAGAAGLLREPGSAGRERADWRRRQLRKVRSVELDQLPEQPLFLAAASPPCPSTSPSPEPADAAAGASRFQPAAGPPPPGAASRCGSHSAELAAARDSGARSPAGAEPPSAAAPSGREMENKETLKGLHKMEDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPIKGDGSEVNNLAAEPQGEGQAGSAAPAPKGRRSPSPGSSPSGRSVKPESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETSRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCGRGAFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVESPASLRAVQQPSSPQQPVAGSQRRNQESSFNLTHFGTQQIPSAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGGSGGSLSAGAASGSSQPSISGDVVEACCSVLSIVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLRPVVDTILVKCADANSRTSQLSISTVLELCKGQAGELAVGREILKAGSIGVGGVDYVLSCILGNQAESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTAVPAVFSKLVTMLNASGSTHFTRMRRRLMAIADEVEIAEVIQLGVEDTVDGHQDSLQAVAPTSCLENSSLEHTVHREKTGKGLSATRLSASSEDISDRLAGVSVGLPSSTTTEQPKPAVQTKGRPHSQCLNSSPLSHAQLMFPAPSAPCSSAPSVPDISKHRPQAFVPCKIPSASPQTQRKFSLQFQRNCSEHRDSDQLSPVFTQSRPPPSSNIHRPKPSRPVPGSTSKLGDATKSSMTLDLGSASRCDDSFGGGGNSGNAVIPSDETVFTPVEDKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDAEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMGHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVAVRCLELQPQDRPPSRELLKHPVFRTTW", "length": 1493 }, "evidence": [ { "id": "E1B847", "url": "https://omabrowser.org/oma/group/E1B847/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q13233-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 1", "gene_name": "MAP3K1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAAGNRASSSGFPGARATSPEAGGGGGALKASSAPAAAAGLLREAGSGGRERADWRRRQLRKVRSVELDQLPEQPLFLAASPPASSTSPSPEPADAAGSGTGFQPVAVPPPHGAASRGGAHLTESVAAPDSGASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASAASPASKGRRSPSPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFNLTHYGTQQIPPAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGSSGSSPSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEMLSVSSSTHFTRMRRRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENSSPECTVHLEKTGKGLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKGRPHSQCLNSSPLSHHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNSMTLDLNSSSKCDDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTTW", "length": 1512 }, "evidence": [ { "id": "E1B847", "url": "https://omabrowser.org/oma/group/E1B847/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q62925-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 1", "gene_name": "Map3k1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAAGDRASSSGFPGAAAASPEAGGGGGALQGSGAPAAGAGLLRETGSAGRERADWRRQQLRKVRSVELDQLPEQPLFLTASPPCPSTSPSPEPADAAAGASGFQPAAGPPPPGAASRCGSHSAELAAARDSGARSPAGAEPPSAAAPSGREMENKETLKGLHKMDDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPIKGDGSEMSNLAAELQGEGQAGSAAPAPKGRRSPSPGSSPSGRSGKPESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETSRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCGRGTFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNCHTLSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVDSPTSLRGVQQPSSPQQPVAGSQRRNQESNFNLTHYGTQQIPPAYKDLAEPWIQAFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGTSGGGSGGSLSAGAASGSSQPSISGDVVEAFCSVLSIVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLRPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGVGGVDYVLSCILGNQAESNNWQELLGRLCLIDRLLLEISAEFYPHIVSTDVSQAEPVEIRYKKLLSLLAFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPPLFSKLVTMLSASGSSHFARMRRRLMAIADEVEIAEVIQLGSEDTLDGQQDSSQALAPPRYPESSSLEHTAHVEKTGKGLKATRLSASSEDISDRLAGVSVGLPSSATTEQPKPTVQTKGRPHSQCLNSSPLSPPQLMFPAISAPCSSAPSVPAGSVTDASKHRPRAFVPCKIPSASPQTQRKFSLQFQRTCSENRDSEKLSPVFTQSRPPPSSNIHRAKASRPVPGSTSKLGDASKNSMTLDLNSASQCDDSFGSGSNSGSAVIPSEETAFTPAEDKCRLDVNPELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKAESDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKANEPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGASVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTTW", "length": 1493 }, "evidence": [ { "id": "E1B847", "url": "https://omabrowser.org/oma/group/E1B847/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1B847", "url": "https://www.uniprot.org/uniprotkb/E1B847" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B847", "url": "https://www.uniprot.org/uniprotkb/E1B847" } ], "pmid": "" }, { "name": "MAP kinase kinase kinase activity", "id": "GO:0004709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004709", "evidence": [ { "database": "UniProtKB", "id": "E1B847", "url": "https://www.uniprot.org/uniprotkb/E1B847" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "E1B847", "url": "https://www.uniprot.org/uniprotkb/E1B847" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "E1B847", "url": "https://www.uniprot.org/uniprotkb/E1B847" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B847", "url": "https://www.uniprot.org/uniprotkb/E1B847" } ], "pmid": "" }, { "name": "tight junction", "id": "GO:0070160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070160", "evidence": [ { "database": "UniProtKB", "id": "E1B847", "url": "https://www.uniprot.org/uniprotkb/E1B847" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "E1B847", "url": "https://www.uniprot.org/uniprotkb/E1B847" } ], "pmid": "" }, { "name": "MAPK cascade", "id": "GO:0000165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000165", "evidence": [ { "database": "UniProtKB", "id": "E1B847", "url": "https://www.uniprot.org/uniprotkb/E1B847" } ], "pmid": "" }, { "name": "cellular response to mechanical stimulus", "id": "GO:0071260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071260", "evidence": [ { "database": "UniProtKB", "id": "E1B847", "url": "https://www.uniprot.org/uniprotkb/E1B847" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1027, "end_pos": 1029, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1064, "end_pos": 1066, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1095, "end_pos": 1097, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1124, "end_pos": 1126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1274, "end_pos": 1276, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1343, "end_pos": 1345, "annotation": "n_glycosylation_sequon" }, { "start_pos": 345, "end_pos": 347, "annotation": "n_glycosylation_sequon" }, { "start_pos": 744, "end_pos": 746, "annotation": "n_glycosylation_sequon" }, { "start_pos": 842, "end_pos": 844, "annotation": "n_glycosylation_sequon" }, { "start_pos": 899, "end_pos": 901, "annotation": "n_glycosylation_sequon" }, { "start_pos": 940, "end_pos": 942, "annotation": "n_glycosylation_sequon" }, { "start_pos": 963, "end_pos": 965, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B847", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B847" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 1238, "end_pos": 1503, "start_aa": "Trp", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B847", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B847" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 442, "end_pos": 491, "start_aa": "Cys", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B847", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B847" }, { "id": "PS50966", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50966" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SWIM-type", "eco_id": "ECO_0000259", "start_pos": 337, "end_pos": 365, "start_aa": "Tyr", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 154, 237, 980, 985, 1061 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1027, "end_pos": 1029 }, { "start_pos": 1064, "end_pos": 1066 }, { "start_pos": 1095, "end_pos": 1097 }, { "start_pos": 1124, "end_pos": 1126 }, { "start_pos": 1274, "end_pos": 1276 }, { "start_pos": 1343, "end_pos": 1345 }, { "start_pos": 345, "end_pos": 347 }, { "start_pos": 744, "end_pos": 746 }, { "start_pos": 842, "end_pos": 844 }, { "start_pos": 899, "end_pos": 901 }, { "start_pos": 940, "end_pos": 942 }, { "start_pos": 963, "end_pos": 965 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_o_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_o_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B9Z9-1", "uniprot_ac": "E1B9Z9", "uniprot_id": "E1B9Z9_BOVIN", "mass": { "chemical_mass": 117407.0, "monoisotopic_mass": 117407.0 }, "refseq": { "ac": "XP_010805365", "name": "transmembrane protease serine 9 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805365" }, "gene_names": [ { "name": "TMPRSS9", "type": "recommended", "evidence": [ { "id": "E1B9Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Z9" } ] }, { "name": "TMPRSS9", "type": "synonym", "evidence": [ { "id": "XP_010805365", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805365" } ] } ], "protein_names": [ { "name": "Transmembrane serine protease 9", "type": "synonym", "evidence": [ { "id": "E1B9Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Z9/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protease serine 9 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010805365", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805365" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9Z9", "url": "https://www.uniprot.org/uniprotkb/E1B9Z9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMPRSS9", "url": "https://www.uniprot.org/uniprotkb/E1B9Z9", "locus": { "chromosome": "7", "start_pos": 21164629, "end_pos": 21221664, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000718", "url": "https://www.ensembl.org/id/ENSBTAG00000000718" } ] } } ], "crossref": [ { "id": "E1B9Z9", "url": "https://alphafold.ebi.ac.uk/entry/E1B9Z9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000718", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000718", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00112", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00112", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "518647", "url": "https://www.ncbi.nlm.nih.gov/gene/518647", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518647", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518647", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HCFNHTR", "url": "https://omabrowser.org/oma/group/HCFNHTR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B9Z9", "url": "https://www.orthodb.org/?gene=E1B9Z9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24252", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24252", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24252:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24252:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00057", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00057", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010805365", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805365", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TLM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLM0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9Z9", "url": "https://www.uniprot.org/uniprotkb/E1B9Z9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9Z9-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Z9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPTASDLQLVPGATKDVLAADAMCCRAALSTVVATSIVLVILGVLVASLSTQGVDVEHMAELRGIRFAPSLQQETSEYYRTLTPALEMLFVSSFQETELESSCLGCTVLSYWEGNASVLVRFRLHFLLLALWTPSPGLEEQLLQRGLHARLQGLGIPLAPYGTIVSAQLTGSQKGPLTERDLKSGHCPGNVFSCGNSQCVTKVNPECDDTADCSDGSDEAHCDCGLQPGWKTAGRIVGGVEASPGEFPWQVSLRENNEHFCGAAIISARWLVSAAHCFNEFQDSPEWVAYVGTTYLSGSEASMVRARVARIITHPSYNSDTADFDVAVLELGRPLPFSRHVQPVCLPAASHIFPPRKKCLISGWGYLKENFLVKPEMLQKATVELLDQALCTSLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEESSGRFFLAGIVSWGIGCAEAQHPGVYARVTSLRDWILETIASASKPPAPTVALASTTLSTAWPTSPKSLVTDTLTKPTLAPSTMPLDLATASKPQECGARPALEKPTRIVGGLGASLGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTKVELVRAQLGTASLSGVGGSPVKVGLRRVVLHPQYNPSILDFDVAVLELARPLVFNKYVQPVCLPLAIQKFPVGRKCVISGWGNTQEGNATKPDLLQQASVGIIDHKACSALYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEETPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILATMSSHLLPTAPLPTTRMPTSSHATRTTAGLTVPEVMASTPTPWATSRVTSQPADRTTTTVTSTPRGQTPLPPAPKTTVGAQLPDCGLAPAAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGTPFLSGADGQLERVARIHKHPFYNLYTLDYDVALLELVGPVRRSRLVRPICLPEPAPRPPDGARCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPQFPGVYTRVAAVRGWIGQNIQE", "length": 1095, "header": "tr|E1B9Z9-1|E1B9Z9_BOVIN Isoform 1 of Transmembrane serine protease 9 OS=Bos taurus OX=9913 GN=TMPRSS9 PE=4 SV=2 CANONICAL=E1B9Z9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TLM0-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Z9/entry#A0AAA9TLM0-1", "sequence": { "sequence": "MEPTASDLQLVPGATKDVLAADAMCCRAALSTVVATSIVLVILGVLVASLSTQGVDVEHMAELRGIRFAPSLQQETSEYYRTLTPALEMLFVSSFQETELESSCLGCTVLSYWEGNASVLVRFRLHFLLLALWTPSPGLEEQLLQRGLHARLQGLGIPLAPYGTIVSAQLTGSQKGPLTERDLKSDCGLQPGWKTAGRIVGGVEASPGEFPWQVSLRENNEHFCGAAIISARWLVSAAHCFNEFQDSPEWVAYVGTTYLSGSEASMVRARVARIITHPSYNSDTADFDVAVLELGRPLPFSRHVQPVCLPAASHIFPPRKKCLISGWGYLKENFLVKPEMLQKATVELLDQALCTSLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEESSGRFFLAGIVSWGIGCAEAQHPGVYARVTSLRDWILETIASASKPPAPTVALASTTLSTAWPTSPKSLVTDTLTKPTLAPSTMPLDLATASKPQECGARPALEKPTRIVGGLGASLGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTKVELVRAQLGTASLSGVGGSPVKVGLRRVVLHPQYNPSILDFDVAVLELARPLVFNKYVQPVCLPLAIQKFPVGRKCVISGWGNTQEGNATKPDLLQQASVGIIDHKACSALYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEETPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILATMSSHLLPTAPLPTTRMPTSSHATRTTAGLTVPEVMASTPTPWATSRVTSQPADRTTTTVTSTPRGQTPLPPAPKTTVGAQLPDCGLAPAAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGTPFLSGADGQLERVARIHKHPFYNLYTLDYDVALLELVGPVRRSRLVRPICLPEPAPRPPDGARCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPQFPGVYTRVAAVRGWIGQNIQE", "length": 1057, "header": "tr|A0AAA9TLM0-1|E1B9Z9_BOVIN Computationally mapped isoform of Transmembrane serine protease 9 OS=Bos taurus OX=9913 GN=TMPRSS9 PE=4 SV=1 CANONICAL=E1B9Z9-1" }, "locus": { "chromosome": "7", "start_pos": 21194842, "end_pos": 21164686, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102488.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102488.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099347.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099347.1" } ] } }, { "isoform_ac": "E1B9Z9-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Z9/entry#E1B9Z9-1", "sequence": { "sequence": "MEPTASDLQLVPGATKDVLAADAMCCRAALSTVVATSIVLVILGVLVASLSTQGVDVEHMAELRGIRFAPSLQQETSEYYRTLTPALEMLFVSSFQETELESSCLGCTVLSYWEGNASVLVRFRLHFLLLALWTPSPGLEEQLLQRGLHARLQGLGIPLAPYGTIVSAQLTGSQKGPLTERDLKSGHCPGNVFSCGNSQCVTKVNPECDDTADCSDGSDEAHCDCGLQPGWKTAGRIVGGVEASPGEFPWQVSLRENNEHFCGAAIISARWLVSAAHCFNEFQDSPEWVAYVGTTYLSGSEASMVRARVARIITHPSYNSDTADFDVAVLELGRPLPFSRHVQPVCLPAASHIFPPRKKCLISGWGYLKENFLVKPEMLQKATVELLDQALCTSLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEESSGRFFLAGIVSWGIGCAEAQHPGVYARVTSLRDWILETIASASKPPAPTVALASTTLSTAWPTSPKSLVTDTLTKPTLAPSTMPLDLATASKPQECGARPALEKPTRIVGGLGASLGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTKVELVRAQLGTASLSGVGGSPVKVGLRRVVLHPQYNPSILDFDVAVLELARPLVFNKYVQPVCLPLAIQKFPVGRKCVISGWGNTQEGNATKPDLLQQASVGIIDHKACSALYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEETPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILATMSSHLLPTAPLPTTRMPTSSHATRTTAGLTVPEVMASTPTPWATSRVTSQPADRTTTTVTSTPRGQTPLPPAPKTTVGAQLPDCGLAPAAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGTPFLSGADGQLERVARIHKHPFYNLYTLDYDVALLELVGPVRRSRLVRPICLPEPAPRPPDGARCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPQFPGVYTRVAAVRGWIGQNIQE", "length": 1095, "header": "tr|E1B9Z9-1|E1B9Z9_BOVIN Isoform 1 of Transmembrane serine protease 9 OS=Bos taurus OX=9913 GN=TMPRSS9 PE=4 SV=2 CANONICAL=E1B9Z9-1" }, "locus": { "chromosome": "7", "start_pos": 21194842, "end_pos": 21164686, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000958.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000958.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000958.5", "url": "https://www.ensembl.org/id/ENSBTAP00000000958.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 479, "start_aa": "Thr", "end_pos": 479, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr479", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 808, "start_aa": "Thr", "end_pos": 808, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr808", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:518647", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518647", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1A8E4-1", "protein_name": "Transmembrane serine protease 9", "gene_name": "TMPRSS9", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDQIKPVLGRRGPRASCWKVTITATVVGGVTALYLGILLACHPAAETSFEHTVELRGITFNSSLQAENSDYYRVLTPALERLFLSSFQDSQLDWSCTGCTILGYRSGNSSVIVRFRLRFAPQDSQPLSSATEEEALRHGLAAALQEQGLSLAAFGTISSASLTAPSDVSPYRPGLKSGSCPGDMFMCHNTQCVWKENPECDGQKDCADASDEKGCDCGSRPAMQTASRIVGGTEASRGEFPWQVSLRENNEHFCGAAILTEKWLVSAAHCFTEFQDPAMWAAYAGTTSISGADSSAVKMGIARIIPHPSYNTDTADYDVAVLELKRPVTFTKYIQPVCLPHAGHHFPTNKKCLISGWGYLKEDFLVKPEFLQKATVKLLDQALCSSLYSHALTDRMLCAGYLEGKIDSCQGDSGGPLVCEEPSGKFFLAGIVSWGIGCAEARRPGVYTRVTKLRDWILDAISPFPTSITRTVPLTHPSTNSNVVTPEELSTTTSTAIPTSSPALAASKPATAPRPQECGGRPGLSKPNKIVGGTDASRGEIPWQVSLQEDSMHFCGATIIGDRWLLSAAHCFNETNPEEIEAYMGTTSLNGTDGSAVKVNVTRVIPHPLFNPMLLDFDVAVLELARPLVFNKYIQPICLPLAVQKFPVGKKCIISGWGNLQEGNVTMSESLQKASVGIIDQKTCNFLYNFSLTERMICAGFLEGKIDSCQGDSGGPLACEVTPGVFYLAGIVSWGIGCAQAKKPGVYSRITKLNDWILDTISQFPGPSTGAPSSSATARTTADILTLRPSTTATGPISETTPSEKAATTVHETSTALKSTEPAKPTQAPVVPCTSLTFRCSSNVCIGKENPECDGVVDCSNGFDESNCDCGLTTALAFSKIVGGSSAARGEWPWQVSLWLRQKEHKCGAVLIADRWLLSAAHCFDIYSDPKMWVAFLGTPFLNGNDGKMEKIFRIYKHPFYNVYSLDYDVALLELSAPVRFSSTIKPICLPDNSHIFQEGARCFITGWGSTKEGGLMTKHLQKAAVNVIGDQDCKKFYPVQISSRMVCAGFPQGTVDSCSVSVRAANGVVGWSKLMQSPHVLQEGRALPPSPAVHPTTSSSHHLLQAHPTHAVLCPSSLGQLRDAHR", "length": 1127 }, "evidence": [ { "id": "E1B9Z9", "url": "https://omabrowser.org/oma/group/E1B9Z9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P69525-1", "protein_name": "Transmembrane protease serine 9", "gene_name": "Tmprss9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPTAPDLQLVPEVTKAVSVSAPDPGPCRTAVIAVVGISMAIVTLGVLSAFFSAQGAHVEHIAELHGIRFTSSLQQENSDFYRLLTHALQTLLHFLLRALQPLSLKQEADILQKGIQARLQEQGLSLAAYGTIVSVELTGRCEGPVTERDLKSGHCPGNVFSCQNGQCVSKENPECDDRVDCSDESDEAQCDCGWQPAWRSAGRIVGGVEAAPGEFPWQVSLRENHEHFCGATIIGARWLVSAAHCFNEFQDPAQWAAQAGSVHLSGSEASAVRTRVLRIAKHPAYDADTADFDVAVLELARPLPFGRYVQPACLPAATHVFPPGKKCLISGWGYLKEDFLVKPEVLQKATVELLDQSLCSSLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYTRVTRLRDWILEVTSAADMPVVPTATPAPATPSTPWPTSPESWAPNTFAKPTAAPSPVPLHPSTTAKPQECGARPAMDKPTRIVGGISAVSGEVPWQASLKEGPRHFCGATVVGDRWLLSAAHCFNHTKVEQVQAHLGTVSLLGVGGSPVKLGLRRVALHPRYNPGILDFDVALLELAQPLVFNKYIQPVCLPLAIHKFPVGRKCMISGWGNMQEGNATKPDILQKASVGIIEQKMCGALYNFSLTDRMLCAGFLEGRVDSCQGDSGGPLACEETPGVFYLAGIVSWGIGCAQAKKPGVYARITRLKDWILKAMSSDPSSMARPHTSSTRLIPSEPPKTTAAGLIIPEATTSRLATPRATIRVTTRPLNTTLSARSTTTRGQTAAPSAPGTTIHSHLPDCGLAPPGALTRIVGGSAASLGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDIYGDPMQWAAFLGTPFLSSTEGQLERVARIYRHPFYNIYTLDYDVALLELAGPVRRSRLVRPICLPGPARPPDGARCVITGWGSLREGGSMARQLQKAAVRVLSEQTCRRFYPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGQWVLTGVTSWGYGCGRPHFPGVYTRVAAVLGWIGQNIQE", "length": 1065 }, "evidence": [ { "id": "E1B9Z9", "url": "https://omabrowser.org/oma/group/E1B9Z9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P69526-1", "protein_name": "Transmembrane protease serine 9", "gene_name": "Tmprss9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPAAPDLQPVPEVTKGVPVPTPDSGCCRAAVTTVVAISVASLTLGVLSAFLSAQGVQVEHTAQLHGVRFTSLLQQENSDFYRLLTPALQTLLHFLLRALQPLSLDQEADILQKGIQARLQGQGLSLAAYGTITSVELTGRCEGPVTERDLKSGHCPGNAFSCQNSQCVSKENPECDDRVDCSDGSDEAQCDCGWQPAWRSAGRIVGGAEAAPGEFPWQVSLRENHEHFCGATIIGARWLVSAAHCFNEFQDPAQWAAQAGSVHLSGSEASAVRARVLRIAKHPAYNADTADFDVAVLELARPLPFGRYVQPACLPAATHVFPPRKKCLISGWGYLKEDFLVKPEVLQKATVELLDQNLCSSLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGVVSWGIGCAEARRPGVYTRVTRLRDWILEVTSSADTPVVPTEAPAPITPSTPWPTSPESRVPNTTAKPTVAPTPAPLHPSTAAKPQECGARPAMDKPTRIVGGISAVSGEVPWQASLKEGSRHFCGATVVGDRWLLSAAHCFNHTKLEQVQAHLGTVSLLGVGGSPVKLGLRSVALHPRYNPGILDFDVALLELAQPLVFNKYIQPVCLPLAIHKFPVGRKCMISGWGNMQEGNATKPDILQKASVGIIEQKMCGALYNFSLTDRMLCAGFLEGRVDSCQGDSGGPLACEETPGVFYLAGIVSWGIGCAQAKKPGVYARITRLKDWILKAMSSDPSSTAHPHTSSTRLIPSQPPTTTAAGLIPEASTGRPATLRATIRVTTRPLNTTLSARSTTTRRQTPAPGTTVFSHLPDCGLAPPGALTRIVGGSAASLGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPMQWAAFLGTPFLSSTEGQLERVARIYRHPFYNIYTLDYDVALLELAGPVRRSRLVRPICLPGPTRPPEGARCVITGWGSLREGGSMARQLQKAAVRVLSEQTCRRFYPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGQWVLTGVTSWGYGCGRPHFPGVYTRVAAVLGWIGQNIRE", "length": 1061 }, "evidence": [ { "id": "E1B9Z9", "url": "https://omabrowser.org/oma/group/E1B9Z9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7Z410-1", "protein_name": "Transmembrane protease serine 9", "gene_name": "TMPRSS9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"length": 1059 }, "evidence": [ { "id": "E1B9Z9", "url": "https://omabrowser.org/oma/group/E1B9Z9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "E1B9Z9", "url": "https://www.uniprot.org/uniprotkb/E1B9Z9" } ], "pmid": "" }, { "name": "serine-type peptidase activity", "id": "GO:0008236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008236", "evidence": [ { "database": "UniProtKB", "id": "E1B9Z9", "url": "https://www.uniprot.org/uniprotkb/E1B9Z9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1B9Z9", "url": "https://www.uniprot.org/uniprotkb/E1B9Z9" } ], "pmid": "" }, { "name": "plasminogen activation", "id": "GO:0031639", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031639", "evidence": [ { "database": "UniProtKB", "id": "E1B9Z9", "url": "https://www.uniprot.org/uniprotkb/E1B9Z9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B9Z9", "url": "https://www.uniprot.org/uniprotkb/E1B9Z9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 581, "end_pos": 583, "annotation": "n_glycosylation_sequon" }, { "start_pos": 672, "end_pos": 674, "annotation": "n_glycosylation_sequon" }, { "start_pos": 697, "end_pos": 699, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], 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"E1B806-1", "uniprot_ac": "E1B806", "uniprot_id": "E1B806_BOVIN", "mass": { "chemical_mass": 23276.0, "monoisotopic_mass": 23276.0 }, "refseq": { "ac": "NP_001178053", "name": "histone deacetylase complex subunit SAP30", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178053" }, "gene_names": [ { "name": "SAP30", "type": "recommended", "evidence": [ { "id": "E1B806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B806" } ] }, { "name": "SAP30", "type": "synonym", "evidence": [ { "id": "NP_001178053", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178053" } ] } ], "protein_names": [ { "name": "Sin3A associated protein 30", "type": "synonym", "evidence": [ { "id": "E1B806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B806/entry#names_and_taxonomy" } ] }, { "name": "Sin3A-associated protein, 30kDa", "type": "synonym", "evidence": [ { "id": "NP_001178053", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178053" } ] }, { "name": "histone deacetylase complex subunit SAP30", "type": "synonym", "evidence": [ { "id": "NP_001178053", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178053" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B806", "url": "https://www.uniprot.org/uniprotkb/E1B806" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SAP30", "url": "https://www.uniprot.org/uniprotkb/E1B806", "locus": { "chromosome": "8", "start_pos": 5766825, "end_pos": 5761560, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015578", "url": "https://www.ensembl.org/id/ENSBTAG00000015578" } ] } } ], "crossref": [ { "id": "E1B806", "url": "https://alphafold.ebi.ac.uk/entry/E1B806", "database": "AlphaFoldDB", "categories": [] }, { "id": "781150", "url": "https://www.ncbi.nlm.nih.gov/gene/781150", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR024145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025718", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025718", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:781150", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781150", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DEYRICC", "url": "https://omabrowser.org/oma/group/DEYRICC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B806", "url": "https://www.orthodb.org/?gene=E1B806", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13286", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13286", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13286:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13286:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13866", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13866", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13867", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13867", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3214815", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214815", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001178053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178053", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TMK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B806", "url": "https://www.uniprot.org/uniprotkb/E1B806", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B806-1", "url": "https://www.uniprot.org/uniprotkb/E1B806-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNGFTPEDMSRGGDAAAAVAAVVAAAAAAASAGNGAGAGAGAEVPGAGAVSAAGPPGAAGPGPGQLCCLREDGERCGRAAGNASFSKRIQKSISQKKVKIELDKSARHLYICDYHKNLIQSVRNRRKRKGSDDDGGDSPVQDIDTPEVDLYQLQVNTLRRYKRHFKLPTRPGLNKAQLVEIVGCHFRSIPVNEKDTLTYFIYSVKNDKNKSDLKVDSSVH", "length": 220, "header": "tr|E1B806-1|E1B806_BOVIN Isoform 1 of Sin3A associated protein 30 OS=Bos taurus OX=9913 GN=SAP30 PE=3 SV=1 CANONICAL=E1B806-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TMK5-1", "url": "https://www.uniprot.org/uniprotkb/E1B806/entry#A0AAA9TMK5-1", "sequence": { "sequence": "PCACRQQQAGAPWSCLEDPGSELIVSAKQVRGTAETPCISREAVSAAGPPGAAGPGPGQLCCLREDGERCGRAAGNASFSKRIQKSISQKKVKIELDKSARHLYICDYHKNLIQSVRNRRKRKGSDDDGGDSPVQDIDTPEVDLYQLQVNTLRRYKRHFKLPTRPGLNKAQLVEIVGCHFRSIPVNEKDTLTYFIYSVKNDKNKSDLKVDSSVH", "length": 214, "header": "tr|A0AAA9TMK5-1|E1B806_BOVIN Computationally mapped isoform of Sin3A associated protein 30 OS=Bos taurus OX=9913 GN=SAP30 PE=3 SV=1 CANONICAL=E1B806-1" }, "locus": { "chromosome": "8", "start_pos": 5766617, "end_pos": 5761698, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108956.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108956.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097566.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097566.1" } ] } }, { "isoform_ac": "E1B806-1", "url": "https://www.uniprot.org/uniprotkb/E1B806/entry#E1B806-1", "sequence": { "sequence": "MNGFTPEDMSRGGDAAAAVAAVVAAAAAAASAGNGAGAGAGAEVPGAGAVSAAGPPGAAGPGPGQLCCLREDGERCGRAAGNASFSKRIQKSISQKKVKIELDKSARHLYICDYHKNLIQSVRNRRKRKGSDDDGGDSPVQDIDTPEVDLYQLQVNTLRRYKRHFKLPTRPGLNKAQLVEIVGCHFRSIPVNEKDTLTYFIYSVKNDKNKSDLKVDSSVH", "length": 220, "header": "tr|E1B806-1|E1B806_BOVIN Isoform 1 of Sin3A associated protein 30 OS=Bos taurus OX=9913 GN=SAP30 PE=3 SV=1 CANONICAL=E1B806-1" }, "locus": { "chromosome": "8", "start_pos": 5766617, "end_pos": 5761879, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020692.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020692.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020692.4", "url": "https://www.ensembl.org/id/ENSBTAP00000020692.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:781150", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781150", "resource": "KEGG Pathway" }, { "id": "R-BTA-3214815", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214815", "resource": "Reactome", "description": "HDACs deacetylate histones" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QT00-1", "protein_name": "Sin3A associated protein 30", "gene_name": "SAP30", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNGFTPEDISRGGDAAAAVAAVVAAAAAAAASAGNGAGAGSGAEVPGAGAVSVAGPPGAAGPGPGQLCCLREDGERCSRAAGNASFSKRIQKSISQKKVKIELDKSARHLYICDYHKNLIQSVRNRRKRKGSDDDGGDSPVQDIDTPEVDLYQLQVNTLRRYKRHFKLPTRPGLNKAQLVEIVGCHFRSIPVNEKDTLTYFIYSVKNDKNKSDLKVDSGVH", "length": 221 }, "evidence": [ { "id": "E1B806", "url": "https://omabrowser.org/oma/group/E1B806/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZC08-1", "protein_name": "Sin3A associated protein 30", "gene_name": "Sap30", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNGFTPEEMSRGGDAAAAVAAVVAAAAAAASAGNGNAAGGGAEVPGAGAVSASGPPGAAGPGPGQLCCLREDGERCGRAAGNASFSKRIQKSISQKKVKIELDKSARHLYICDYHKNLIQSVRNRRKRKGSDDDGGDSPVQDIDTPEVDLYQLQVNTLRRYKRHFKLPTRPGLNKAQLVEIVGCHFKSIPVNEKDTLTCFIYSVRNDKNKSDLKADSGVH", "length": 220 }, "evidence": [ { "id": "E1B806", "url": "https://omabrowser.org/oma/group/E1B806/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HKY1-1", "protein_name": "Histone deacetylase complex subunit SAP30", "gene_name": "Sap30", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNGFTPEEMSRSGDAAAAVAAVVAAAAAAASAGNGNAAGGGAEVPGAGAVSAAGPPGAAGPGLGQLCCLREDGERCGRAAGNASFSKRIQKSISQKKVKIELDKSARHLYICDYHKNLIQSVRNRRKRKGSDDDGGDSPVQDIDTPEVDLYQLQVNTLRRYKRHFKLPTRPGLNKAQLVEIVGCHFRSIPVNEKDTLTYFIYSVKNDKNKSDLKVDSGVH", "length": 220 }, "evidence": [ { "id": "E1B806", "url": "https://omabrowser.org/oma/group/E1B806/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O75446-1", "protein_name": "Histone deacetylase complex subunit SAP30", "gene_name": "SAP30", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNGFTPDEMSRGGDAAAAVAAVVAAAAAAASAGNGTGAGTGAEVPGAGAVSAAGPPGAAGPGPGQLCCLREDGERCGRAAGNASFSKRIQKSISQKKVKIELDKSARHLYICDYHKNLIQSVRNRRKRKGSDDDGGDSPVQDIDTPEVDLYQLQVNTLRRYKRHFKLPTRPGLNKAQLVEIVGCHFRSIPVNEKDTLTYFIYSVKNDKNKSDLKVDSGVH", "length": 220 }, "evidence": [ { "id": "E1B806", "url": "https://omabrowser.org/oma/group/E1B806/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O88574-1", "protein_name": "Histone deacetylase complex subunit SAP30", "gene_name": "Sap30", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNGFTPEEMSRGGDAAAAVAAVVAAAAAAASAGNGNAAGGGAEVPGAGAVSASGPPGAAGPGPGQLCCLREDGERCGRAAGNASFSKRIQKSISQKKVKIELDKSARHLYICDYHKNLIQSVRNRRKRKGSDDDGGDSPVQDIDTPEVDLYQLQVNTLRRYKRHFKLPTRPGLNKAQLVEIVGCHFKSIPVNEKDTLTCFIYSVRNDKNKSDLKADSGVH", "length": 220 }, "evidence": [ { "id": "E1B806", "url": "https://omabrowser.org/oma/group/E1B806/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1B806", "url": "https://www.uniprot.org/uniprotkb/E1B806" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B806", "url": "https://www.uniprot.org/uniprotkb/E1B806" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "E1B806", "url": "https://www.uniprot.org/uniprotkb/E1B806" } ], "pmid": "" }, { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "E1B806", "url": "https://www.uniprot.org/uniprotkb/E1B806" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B806", "url": "https://www.uniprot.org/uniprotkb/E1B806" } ], "pmid": "" }, { "name": "histone deacetylase complex", "id": "GO:0000118", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000118", "evidence": [ { "database": "UniProtKB", "id": "E1B806", "url": "https://www.uniprot.org/uniprotkb/E1B806" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1B806", "url": "https://www.uniprot.org/uniprotkb/E1B806" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "E1B806", "url": "https://www.uniprot.org/uniprotkb/E1B806" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "E1B806", "url": "https://www.uniprot.org/uniprotkb/E1B806" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 82, "end_pos": 84, "annotation": 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"uniprot_ac": "E1B7G0", "uniprot_id": "E1B7G0_BOVIN", "mass": { "chemical_mass": 58146.0, "monoisotopic_mass": 58146.0 }, "refseq": { "ac": "XP_005203317", "name": "interferon lambda receptor 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203317" }, "gene_names": [ { "name": "IFNLR1", "type": "recommended", "evidence": [ { "id": "E1B7G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G0" } ] }, { "name": "IFNLR1", "type": "synonym", "evidence": [ { "id": "XP_005203317", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203317" } ] }, { "name": "IL28RA", "type": "synonym", "evidence": [ { "id": "XP_005203317", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203317" } ] } ], "protein_names": [ { "name": "Interferon lambda receptor 1", "type": "recommended", "evidence": [ { "id": "E1B7G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G0/entry#names_and_taxonomy" } ] }, { "name": "Cytokine receptor class-II member 12", "type": "synonym", "evidence": [ { "id": "E1B7G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G0/entry#names_and_taxonomy" } ] }, { "name": "Cytokine receptor family 2 member 12", "type": "synonym", "evidence": [ { "id": "E1B7G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G0/entry#names_and_taxonomy" } ] }, { "name": "Interleukin-28 receptor subunit alpha", "type": "synonym", "evidence": [ { "id": "E1B7G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G0/entry#names_and_taxonomy" } ] }, { "name": "interferon lambda receptor 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005203317", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203317" } ] } ], "function": [ { "annotation": "The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.", "evidence": [ { "database": "UniProtKB", "id": "E1B7G0", "url": "https://www.uniprot.org/uniprotkb/E1B7G0#function" }, { "database": "UniProtKB", "id": "ARBA00054089", "url": "https://www.uniprot.org/uniprotkb/ARBA00054089#function" }, { "database": "UniProtKB", "id": "A0AAA9TN26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN26#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7G0", "url": "https://www.uniprot.org/uniprotkb/E1B7G0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IFNLR1", "url": "https://www.uniprot.org/uniprotkb/E1B7G0", "locus": { "chromosome": "2", "start_pos": 128741092, "end_pos": 128718373, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001101", "url": "https://www.ensembl.org/id/ENSBTAG00000001101" } ] } } ], "crossref": [ { "id": "E1B7G0", "url": "https://alphafold.ebi.ac.uk/entry/E1B7G0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001101", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001101", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616826", "url": "https://www.ncbi.nlm.nih.gov/gene/616826", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050650", "url": 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"categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8854691", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854691", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005203317", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203317", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TN26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TN26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN26-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7G0", "url": "https://www.uniprot.org/uniprotkb/E1B7G0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7G0-1", "url": "https://www.uniprot.org/uniprotkb/E1B7G0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTGARRWAPLLLCLLQSAPGRPLLAPPQNVTLLSRDFSVYLTWLPGPGNPQNVTYFVAYQSFAPPRRWRRVKKCAGTKELVCSLMCLEKQDLCNKFKGRVQAVSPSARSPWVESKFMDYFFEVEPAPPVLVFNQTEEILIVNATYQLPHCLPQPDMNYEVNFWKEGTKNKTRFPDTRHGQPVQIPLQPDTSGHHCLSARTIYFFGNPKYSEFSEPTCFFLEAPGSNWALLLLLPFLLPLLLAVAIGPVMWKTFRENPWFQQTKMPQALSFSGHRLCGATFQPGGPECLHDLIVCPQKEVTRRVRLTSRVRAPAPVQARPEKDSAEEKDGEESTDEEDLDPGVSFQPYVEPPPFLGQEPQSPGPTKAGEPWTPLVQGEGSSACSSSGRSWVSTAGSSSPWDEAGSSGYLAKKGPGQGMGREEHQKPLPPPKDSSSLGEPSKDNLSSWTSWGLSSPGLNLVPGEPPVSLRTLTFCWDSSPEDDEGEEEEEEEGWRESESEDSGAGSWGAKSLQRTEVRPLGHYLAR", "length": 524, "header": "tr|E1B7G0-1|E1B7G0_BOVIN Isoform 1 of Interferon lambda receptor 1 OS=Bos taurus OX=9913 GN=IFNLR1 PE=3 SV=3 CANONICAL=E1B7G0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TN26-1", "url": "https://www.uniprot.org/uniprotkb/E1B7G0/entry#A0AAA9TN26-1", "sequence": { "sequence": "MTGARRWAPLLLCLLQSAPGRPLLAPPQNVTLLSRDFSVYLTWLPGPGNPQNVTYFVAYQSFAPPRRWRRVKKCAGTKELVCSLMCLEKQDLCNKFKGRVQAVSPSARSPWVESKFMDYFFEVEPAPPVLVFNQTEEILIVNATYQLPHCLPQPDMNYEVNFWKEGTKNKTRFPDTRHGQPVQIPLQPDTSGHHCLSARTIYFFGNPKYSEFSEPTCFFLEAPELLRTQTLRGNLSARWPRVPAR", "length": 245, "header": "tr|A0AAA9TN26-1|E1B7G0_BOVIN Computationally mapped isoform of Interferon lambda receptor 1 OS=Bos taurus OX=9913 GN=IFNLR1 PE=3 SV=1 CANONICAL=E1B7G0-1" }, "locus": { "chromosome": "2", "start_pos": 128739385, "end_pos": 128718642, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124971.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124971.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099757.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099757.1" } ] } }, { "isoform_ac": "E1B7G0-1", "url": "https://www.uniprot.org/uniprotkb/E1B7G0/entry#E1B7G0-1", "sequence": { "sequence": "MTGARRWAPLLLCLLQSAPGRPLLAPPQNVTLLSRDFSVYLTWLPGPGNPQNVTYFVAYQSFAPPRRWRRVKKCAGTKELVCSLMCLEKQDLCNKFKGRVQAVSPSARSPWVESKFMDYFFEVEPAPPVLVFNQTEEILIVNATYQLPHCLPQPDMNYEVNFWKEGTKNKTRFPDTRHGQPVQIPLQPDTSGHHCLSARTIYFFGNPKYSEFSEPTCFFLEAPGSNWALLLLLPFLLPLLLAVAIGPVMWKTFRENPWFQQTKMPQALSFSGHRLCGATFQPGGPECLHDLIVCPQKEVTRRVRLTSRVRAPAPVQARPEKDSAEEKDGEESTDEEDLDPGVSFQPYVEPPPFLGQEPQSPGPTKAGEPWTPLVQGEGSSACSSSGRSWVSTAGSSSPWDEAGSSGYLAKKGPGQGMGREEHQKPLPPPKDSSSLGEPSKDNLSSWTSWGLSSPGLNLVPGEPPVSLRTLTFCWDSSPEDDEGEEEEEEEGWRESESEDSGAGSWGAKSLQRTEVRPLGHYLAR", "length": 524, "header": "tr|E1B7G0-1|E1B7G0_BOVIN Isoform 1 of Interferon lambda receptor 1 OS=Bos taurus OX=9913 GN=IFNLR1 PE=3 SV=3 CANONICAL=E1B7G0-1" }, "locus": { "chromosome": "2", "start_pos": 128740088, "end_pos": 128718642, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001456.6", "url": "https://www.ensembl.org/id/ENSBTAT00000001456.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001456.4", "url": "https://www.ensembl.org/id/ENSBTAP00000001456.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 364, "start_aa": "Thr", "end_pos": 364, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr364", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-449836", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-449836", "resource": "Reactome", "description": "Other interleukin signaling" }, { "id": "R-BTA-8854691", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854691", "resource": "Reactome", "description": "Interleukin-20 family signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZB58-1", "protein_name": "Interferon lambda receptor 1", "gene_name": "Ifnlr1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWRAGRWAPLLLFLMQSALGRPRLAPPRNVTLLSQNFTVYLTWLPGLGSPPNVTYFVTYKSYNNHWRRVEHCAGISTLVCPMMCLKKQDLYIKFKGRVQAASAHVKSPWVESRYLEYIFDVELAPPTLVLSQKEKILNVNATYQLPPCMPRSLELKYQVEFWKEDLRSKTLFPDTPYGQPVKIPLQQDARGRHCFSARTVYTLTHTKYSLFSEPSCIFLAAPGANRAVLAVPLLLLLLIAAAAAGTAWKKMDGNPWFQWVKMPQALDFSENRHPVATFQPSGPEFSGDLILCPQKELTIRTRPVPRVRGPATLQAGSEKDSTEDEDEDTDDDGDSIQPYLERPLFVREKLQVTEHSEADESGVDSVGSEGSSAWDSSGGSWSSTGVSSGDSSYKDEAGSSSCLDQKKPDQEPHGDGHQGPLPCLEFSEDLGTVEELLKDDLSGWRIWGTLSPKRDLAPVEPPVSLQTLTFCWDSNPEEEEEEEEEEEEEEEEEEEDWESDLKDSNTSCWDASSPQRTDVRGGMLGDYMVR", "length": 530 }, "evidence": [ { "id": "E1B7G0", "url": "https://omabrowser.org/oma/group/E1B7G0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8CGK5-1", "protein_name": "Interferon lambda receptor 1", "gene_name": "Ifnlr1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWRADRWAPLLLFLLQSALGRPRLAPPRNVTLFSQNFTVYLTWLPGLGSPPNVTYFVTYQSYIKTGWRPVEHCAGIKALVCPLMCLKKLNLYSKFKGRVQAASAHGRSPRVESRYLEYLFDVELAPPTLVLTQMEKILRVNATYQLPPCMPSLELKYQVEFWKEGLGSKTLFPDTPYGQPVQIPLQQGASRRHCLSARTVYTLIDIKYSQFSEPSCIFLEAPGDKRAVLAMPSLLLLLIAAVAAGVAWKIMKGNPWFQGVKTPRALDFSEYRYPVATFQPSGPEFSDDLILCPQKELTIRNRPAPQVRNPATLQAGPERDSTEDEDEDTDYDDDGDSVQPYLERPLFISEKPRVMEHSETDESGVDSGGPWTSPVGSDGSSAWDSSDRSWSSTGDSSYKDEVGSSSCLDRKEPDQAPCGDWLQEALPCLEFSEDLGTVEEPLKDGLSGWRISGSLSSKRDLAPVEPPVSLQTLTFCWVNNPEGEEEQEDEEEEEEEEEEEDWESEPKGSNAGCWGTSSVQRTEVRGRMLGDYLVR", "length": 535 }, "evidence": [ { "id": "E1B7G0", "url": "https://omabrowser.org/oma/group/E1B7G0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IU57-1", "protein_name": "Interferon lambda receptor 1", "gene_name": "IFNLR1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGPERWGPLLLCLLQAAPGRPRLAPPQNVTLLSQNFSVYLTWLPGLGNPQDVTYFVAYQSSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEYLDYLFEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLFPVTPHGQPVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEVPEANWAFLVLPSLLILLLVIAAGGVIWKTLMGNPWFQRAKMPRALDFSGHTHPVATFQPSRPESVNDLFLCPQKELTRGVRPTPRVRAPATQQTRWKKDLAEDEEEEDEEDTEDGVSFQPYIEPPSFLGQEHQAPGHSEAGGVDSGRPRAPLVPSEGSSAWDSSDRSWASTVDSSWDRAGSSGYLAEKGPGQGPGGDGHQESLPPPEFSKDSGFLEELPEDNLSSWATWGTLPPEPNLVPGGPPVSLQTLTFCWESSPEEEEEARESEIEDSDAGSWGAESTQRTEDRGRTLGHYMAR", "length": 520 }, "evidence": [ { "id": "E1B7G0", "url": "https://omabrowser.org/oma/group/E1B7G0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1B7G0", 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{ "database": "UniProtKB", "id": "E1B7G0", "url": "https://www.uniprot.org/uniprotkb/E1B7G0" } ], "pmid": "" }, { "name": "cytokine-mediated signaling pathway", "id": "GO:0019221", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019221", "evidence": [ { "database": "UniProtKB", "id": "E1B7G0", "url": "https://www.uniprot.org/uniprotkb/E1B7G0" } ], "pmid": "" }, { "name": "mucosal immune response", "id": "GO:0002385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002385", "evidence": [ { "database": "UniProtKB", "id": "E1B7G0", "url": "https://www.uniprot.org/uniprotkb/E1B7G0" } ], "pmid": "" }, { "name": "positive regulation of cellular respiration", "id": "GO:1901857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901857", "evidence": [ { "database": "UniProtKB", "id": "E1B7G0", "url": "https://www.uniprot.org/uniprotkb/E1B7G0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cytokine receptor activity", "id": "GO:0004896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004896", "evidence": [ { "database": "UniProtKB", "id": "E1B7G0", "url": "https://www.uniprot.org/uniprotkb/E1B7G0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" }, { "start_pos": 169, "end_pos": 171, "annotation": "n_glycosylation_sequon" }, { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" }, { "start_pos": 442, "end_pos": 444, "annotation": "n_glycosylation_sequon" }, { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7G0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 524, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": 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"species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BAA0", "url": "https://www.uniprot.org/uniprotkb/E1BAA0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDK5R2", "url": "https://www.uniprot.org/uniprotkb/E1BAA0", "locus": { "chromosome": "2", "start_pos": 106905936, "end_pos": 106898764, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031052", "url": "https://www.ensembl.org/id/ENSBTAG00000031052" } ] } } ], "crossref": [ { "id": "ENSBTAG00000031052", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031052", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "528533", "url": "https://www.ncbi.nlm.nih.gov/gene/528533", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004944", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004944", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528533", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528533", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GDFMCRR", "url": "https://omabrowser.org/oma/group/GDFMCRR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAA0", "url": "https://www.orthodb.org/?gene=E1BAA0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23401", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23401", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23401:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23401:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03261", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03261", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002685622", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685622", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TNI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNI9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAA0", "url": "https://www.uniprot.org/uniprotkb/E1BAA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAA0-1", "url": "https://www.uniprot.org/uniprotkb/E1BAA0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPAGKGGKGESRLKRPSVLISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDPPDGGGAAKPLAVPVPTVPAAAATCEPPSGSSAGVPPPGSGGGKPPPPPPPAPQAAPPVPGGSPRRVIVQASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVYLLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRLIQRLSPQMLRLNADPHFFTQVFQDLKNEGEASASAGGPPNGGAPAAPSTSSSSSAARDSCATGAKHWTMNLDR", "length": 373, "header": "tr|E1BAA0-1|E1BAA0_BOVIN Isoform 1 of Cyclin-dependent kinase 5 activator OS=Bos taurus OX=9913 GN=CDK5R2 PE=3 SV=2 CANONICAL=E1BAA0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TNI9-1", "url": "https://www.uniprot.org/uniprotkb/E1BAA0/entry#A0AAA9TNI9-1", "sequence": { "sequence": "MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPAGKGGKGESRLKRPSVLISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDPPDGGGAAKPLAVPVPTVPAAAATCEPPSGSSAGVPPPGSGGGKPPPPPPPAPQAAPPVPGGSPRRVIVQASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRLIQRLSPQMLRLNADPHFFTQVFQDLKNEGEASASAGGPPNGGAPAAPSTSSSSSAARDSCATGAKHWTMNLDR", "length": 342, "header": "tr|A0AAA9TNI9-1|E1BAA0_BOVIN Computationally mapped isoform of Cyclin-dependent kinase 5 activator OS=Bos taurus OX=9913 GN=CDK5R2 PE=3 SV=1 CANONICAL=E1BAA0-1" }, "locus": { "chromosome": "2", "start_pos": 106900175, "end_pos": 106899057, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132982.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132982.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099927.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099927.1" } ] } }, { "isoform_ac": "E1BAA0-1", "url": "https://www.uniprot.org/uniprotkb/E1BAA0/entry#E1BAA0-1", "sequence": { "sequence": "MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPAGKGGKGESRLKRPSVLISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDPPDGGGAAKPLAVPVPTVPAAAATCEPPSGSSAGVPPPGSGGGKPPPPPPPAPQAAPPVPGGSPRRVIVQASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVYLLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRLIQRLSPQMLRLNADPHFFTQVFQDLKNEGEASASAGGPPNGGAPAAPSTSSSSSAARDSCATGAKHWTMNLDR", "length": 373, "header": "tr|E1BAA0-1|E1BAA0_BOVIN Isoform 1 of Cyclin-dependent kinase 5 activator OS=Bos taurus OX=9913 GN=CDK5R2 PE=3 SV=2 CANONICAL=E1BAA0-1" }, "locus": { "chromosome": "2", "start_pos": 106904715, "end_pos": 106903597, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096799.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096799.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090625.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090625.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 127, "start_aa": "Thr", "end_pos": 127, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr127", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:528533", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528533", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZH13-1", "protein_name": "Cyclin-dependent kinase 5 activator", "gene_name": "CDK5R2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGTVLSLSPAASSGKGGGGGGLLADKAPGRLPGKGESRLKRPGVLISALTWKRLVAASAKKKKSTKKVTPKPGGGPPPGAQPDPLVVQRNRENLRKSLGGPSEGAKQGPLAVPVPTVPSAPQELHPGSGGGKPPPPPSSRASGSPRRVVVQASTGELLRCLGDFVCRRCYRLKELSPGELISWFRSVDRSLLLQGWQDQGFITPANLVFVYLLCREALRGEDIGSQAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEGDKGRFWERCLGIIQRLSAKMLRINADPHYFTQLFQDLKSEGEGGDGSKHWTISLDR", "length": 315 }, "evidence": [ { "id": "E1BAA0", "url": "https://omabrowser.org/oma/group/E1BAA0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1M491-1", "protein_name": "Cyclin-dependent kinase 5 regulatory subunit 2", "gene_name": "Cdk5r2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPAGKGGKGESRLKRPSVLISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDAPDGGGAAKPLAVPVPTVPASAATCEPPSGGSAAAPPPGSGGGKPPPPPPPAPQAAPPAPGGSPRRVIVQASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVYLLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRLIQRLSPQMLRLNADPHFFTQVFQDLKNEGEAAVSGFTGRGVGVGDDRGKCTPNFVHPFRLSAPPSFHFCPGLPLPCCGHLKVLHPGFCPVPHFSVSSSFLLSAVPLSLPVLWHSLGFTLFYLTPEPDGPPLLSPVLQHLYFHVPFPSSTHMSPLPSCLPSLSLLVSSCTP", "length": 470 }, "evidence": [ { "id": "E1BAA0", "url": "https://omabrowser.org/oma/group/E1BAA0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LCB4-1", "protein_name": "Cyclin-dependent kinase 5 activator", "gene_name": "CDK5R2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPVGKGGKGESRLKRPSVLISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDPPDGGGAAKPLAVPVPTVPTTAATCEPPSGGSAAAPQPGSGGGKPPPPPPPAPQAAPPVPGGSPRRVIVQASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVYLLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRLIQRLSPQMLRLNADPHFFTQVFQDLKNEGEAAAGSGGPPSGERPRPPPPPQLPGTAARLEPSTGL", "length": 365 }, "evidence": [ { "id": "E1BAA0", "url": "https://omabrowser.org/oma/group/E1BAA0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O35926-1", "protein_name": "Cyclin-dependent kinase 5 activator 2", "gene_name": "Cdk5r2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPAGKGGKGESRLKRPSVLISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDGPDGGGTAKPLAVPVPTVPTTAATCEPPSGGSAAAPPPGSGGGKPPPPPPPAPQAAPPAPGGSPRRVIVQASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVYLLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRLIQRLSPQMLRLNADPHFFTQVFQDLKNEGEAAASTGGPPSGSSASTTSSSSARDSCATGAKHWTMNLDR", "length": 369 }, "evidence": [ { "id": "E1BAA0", "url": "https://omabrowser.org/oma/group/E1BAA0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q13319-1", "protein_name": "Cyclin-dependent kinase 5 activator 2", "gene_name": "CDK5R2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPVGKGGKGESRLKRPSVLISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDPPDGGGTAKPLAVPVPTVPAAAATCEPPSGGSAAAQPPGSGGGKPPPPPPPAPQVAPPVPGGSPRRVIVQASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVYLLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRLIQRLSPQMLRLNADPHFFTQVFQDLKNEGEAAASGGGPPSGGAPAASSAARDSCAAGTKHWTMNLDR", "length": 367 }, "evidence": [ { "id": "E1BAA0", "url": "https://omabrowser.org/oma/group/E1BAA0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BAA0", "url": "https://www.uniprot.org/uniprotkb/E1BAA0" } ], "pmid": "" }, { "name": "protein kinase 5 complex", "id": "GO:0016533", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016533", "evidence": [ { "database": "UniProtKB", "id": "E1BAA0", "url": "https://www.uniprot.org/uniprotkb/E1BAA0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BAA0", "url": "https://www.uniprot.org/uniprotkb/E1BAA0" } ], "pmid": "" }, { "name": "growth cone", "id": "GO:0030426", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "evidence": [ { "database": "UniProtKB", "id": "E1BAA0", "url": "https://www.uniprot.org/uniprotkb/E1BAA0" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "E1BAA0", "url": "https://www.uniprot.org/uniprotkb/E1BAA0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "cyclin-dependent protein serine/threonine kinase activator activity", "id": "GO:0061575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061575", "evidence": [ { "database": "UniProtKB", "id": "E1BAA0", "url": "https://www.uniprot.org/uniprotkb/E1BAA0" } ], "pmid": "" }, { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "E1BAA0", "url": "https://www.uniprot.org/uniprotkb/E1BAA0" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "E1BAA0", "url": "https://www.uniprot.org/uniprotkb/E1BAA0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "E1BAA0", "url": "https://www.uniprot.org/uniprotkb/E1BAA0" } ], "pmid": "" }, { "name": "regulation of cytoskeleton organization", "id": "GO:0051493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051493", "evidence": [ { "database": "UniProtKB", "id": "E1BAA0", "url": "https://www.uniprot.org/uniprotkb/E1BAA0" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "E1BAA0", "url": "https://www.uniprot.org/uniprotkb/E1BAA0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 127 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A7YVD7-1", "uniprot_ac": "A7YVD7", "uniprot_id": "NDUF6_BOVIN", "mass": { "chemical_mass": 38103.0, "monoisotopic_mass": 38103.0 }, "refseq": { "ac": "NP_001098859", "name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098859" }, "gene_names": [ { "name": "NDUFAF6", "type": "recommended", "evidence": [ { "id": "A7YVD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YVD7" } ] }, { "name": "C14H8orf38", "type": "synonym", "evidence": [ { "id": "NP_001098859", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098859" } ] }, { "name": "NDUFAF6", "type": "synonym", "evidence": [ { "id": "NP_001098859", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098859" } ] } ], "protein_names": [ { "name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6", "type": "recommended", "evidence": [ { "id": "A7YVD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YVD7/entry#names_and_taxonomy" } ] }, { "name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 precursor", "type": "synonym", "evidence": [ { "id": "NP_001098859", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098859" } ] }, { "name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6", "type": "synonym", "evidence": [ { "id": "NP_001098859", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098859" } ] }, { "name": "UPF0551 protein C8orf38 homolog, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001098859", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098859" } ] } ], "function": [ { "annotation": "Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of complex I subunit MT-ND1.", "evidence": [ { "database": "UniProtKB", "id": "A7YVD7", "url": "https://www.uniprot.org/uniprotkb/A7YVD7#function" }, { "database": "UniProtKB", "id": "Q330K2", "url": "https://www.uniprot.org/uniprotkb/Q330K2#function" }, { "database": "UniProtKB", "id": "A0AAA9TPS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPS2#function" }, { "database": "UniProtKB", "id": "ARBA00056665", "url": "https://www.uniprot.org/uniprotkb/ARBA00056665#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7YVD7", "url": "https://www.uniprot.org/uniprotkb/A7YVD7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NDUFAF6", "url": "https://www.uniprot.org/uniprotkb/A7YVD7", "locus": { "chromosome": "14", "start_pos": 69265371, "end_pos": 69301594, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007570", "url": "https://www.ensembl.org/id/ENSBTAG00000007570" } ] } } ], "crossref": [ { "id": "A7YVD7", "url": "https://alphafold.ebi.ac.uk/entry/A7YVD7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007570", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007570", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "523017", "url": "https://www.ncbi.nlm.nih.gov/gene/523017", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008949", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008949", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523017", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523017", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MINAREQ", "url": "https://omabrowser.org/oma/group/MINAREQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A7YVD7", "url": "https://www.orthodb.org/?gene=A7YVD7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21181", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21181", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21181:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21181:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00494", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00494", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6799198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001098859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098859", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TPS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPS2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7YVD7", "url": "https://www.uniprot.org/uniprotkb/A7YVD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7YVD7-1", "url": "https://www.uniprot.org/uniprotkb/A7YVD7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASTLGSAWGPLRLGVPGLCRRRPPRGLWARARRLSEPVASGRSVAAGSGLGASGTDRYCLELLRKRDYEGYLCSLLLPAESRSSAFALRAFNVELAQIKDSVSEKTIGLMRMQFWKKTVDDIYSDNPPHQPVAIELWKAVRRHNLTKRWLMKIIDEREKNLDDKAYRNIQELENYAENTQSSLLYLTLEILGIKDLHADHAASHIGKAQGIVTCLRATPYHGSRRRVFLPMDICMLHGVSQEDFLRKSQDRNVRDVVYDVASQAHLHLKHARSFHRSIPVKAFPAFLQTVALEDYLKKIQQVDFDLFHPSLQRKNTLLPLSLYIQSWRKRY", "length": 333, "header": "sp|A7YVD7-1|NDUF6_BOVIN Isoform 1 of NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 OS=Bos taurus OX=9913 GN=NDUFAF6 PE=2 SV=1 CANONICAL=A7YVD7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TPS2-1", "url": "https://www.uniprot.org/uniprotkb/A7YVD7/entry#A0AAA9TPS2-1", "sequence": { "sequence": "MAASTLGSAWGPLRLGVPGLCRRRPPRGLWARARRLSEPVASGRSVAAGSGLGASGTDRYCLELLRKRDYEGYLCSLLLPAESRSSAFALRAFNVELAQIKDSVSEKTIGLMRMQFWKKTVDDIYSDNPPHQPVAIELWKAVRRHNLTKRWLMKIIDEREKNLDDKAYRNIQELENYAENTQSSLLYLTLEILGIKDLHADHAASHIGKAQGIVTCLRATPYHGSRRRVFLPMDICMLHGVSQEDFLRKSQDRNVRDVVYDVASQAHLHLKHVALEDYLKKIQQVDFDLFHPSLQRKNTLLPLS", "length": 304, "header": "tr|A0AAA9TPS2-1|NDUF6_BOVIN Computationally mapped isoform of NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 OS=Bos taurus OX=9913 GN=NDUFAF6 PE=2 SV=1 CANONICAL=A7YVD7-1" }, "locus": { "chromosome": "14", "start_pos": 69301591, "end_pos": 69266822, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115480.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115480.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099018.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099018.1" } ] } }, { "isoform_ac": "A7YVD7-1", "url": "https://www.uniprot.org/uniprotkb/A7YVD7/entry#A7YVD7-1", "sequence": { "sequence": "MAASTLGSAWGPLRLGVPGLCRRRPPRGLWARARRLSEPVASGRSVAAGSGLGASGTDRYCLELLRKRDYEGYLCSLLLPAESRSSAFALRAFNVELAQIKDSVSEKTIGLMRMQFWKKTVDDIYSDNPPHQPVAIELWKAVRRHNLTKRWLMKIIDEREKNLDDKAYRNIQELENYAENTQSSLLYLTLEILGIKDLHADHAASHIGKAQGIVTCLRATPYHGSRRRVFLPMDICMLHGVSQEDFLRKSQDRNVRDVVYDVASQAHLHLKHARSFHRSIPVKAFPAFLQTVALEDYLKKIQQVDFDLFHPSLQRKNTLLPLSLYIQSWRKRY", "length": 333, "header": "sp|A7YVD7-1|NDUF6_BOVIN Isoform 1 of NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 OS=Bos taurus OX=9913 GN=NDUFAF6 PE=2 SV=1 CANONICAL=A7YVD7-1" }, "locus": { "chromosome": "14", "start_pos": 69301591, "end_pos": 69266792, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009959.5", "url": "https://www.ensembl.org/id/ENSBTAT00000009959.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009959.4", "url": "https://www.ensembl.org/id/ENSBTAP00000009959.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:523017", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523017", "resource": "KEGG Pathway" }, { "id": "R-BTA-6799198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "resource": "Reactome", "description": "Complex I biogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PQC5-1", "protein_name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6", "gene_name": "NDUFAF6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAATAAGGLRPVSFPRLLRAVGARGGLPWPRGGRAAAAGWSRPEPGGEAQYCAELLRKRDYEGFLCSLLLPAESRTSAFALRAFNVELAQIKDSITQKTTGLMRMQFWRKAVEDIYCDNPPHQPVAVALWRAVKRHNLSKMWFMKIIDEREKNLDDRAYRNIQELETYAENTQSALFYLTLEMLGVRDVHADHAASHIGKAQGIVTCLRATPYHCARRKVFLPMDICMLHGVSQEDFIRCKQEKHVRDVIYDIASQAHIHLEHARSFSKKVPVKAYPAFYYTVALDDYLYNIRKVDFNIFHPSLQKRNTLLPLYLYIRTWKKTY", "length": 325 }, "evidence": [ { "id": "A7YVD7", "url": "https://omabrowser.org/oma/group/A7YVD7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A2AIL4-1", "protein_name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6", "gene_name": "Ndufaf6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATSMLGSVRGPRPFGLANLFHRQPPRDAWERVRRLPGPSAVRRSVAAASGPGIPGSHLYCLELLRKRDYESYLCSLLFPAECQRSASALRAFNVELAQVKDSVSEKTIGLMRMQFWKKAVEDMYCDNPPHQPVAIELWKAVKKHNLTKRWLMRIIDEREKNLDDKAYRSMQELENYAENTQGSLLYLTLEVLGVKDLHADHAASHIGKAQGIVTCLRATPYHSSRRQVFLPMDVCVQHGVSQEDFLRRNQDKNVRDVVYDIASQAHLHLKHARSFHRSVPAEAFPAFLQTVSLEDYLKKIQRVDFDIFHPSLQQKNMLLPLSLYIQSWRKRY", "length": 333 }, "evidence": [ { "id": "A7YVD7", "url": "https://omabrowser.org/oma/group/A7YVD7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZN43-1", "protein_name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6", "gene_name": "Ndufaf6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATSMLGSVPGPRPFGLAGLFRRRPPRDPWERVRRLPRLSAVRRSVAAASGPGIPDSHLYCLELLRKRDYESYLCSLLFPAECQRSASALRAFNVELAQVKDSVSEKTIGLMRMQFWRKAVEDMFCDNPPHQPVAMELWKAVKRHNLTKRWLLRIIDEREKNLDDKAYRSIRELETYAENTQSSLLYLTLEVLGVKDVHADHAASHIGKAQGIVTCLRATPYHSSRRQVFLPMDVCVQHGVSQEDFLRRNQDKNVRDVVYDIASQAHLHLKHARSFHSRVPAEAFPAFLQTVSLEDYLKKIQRVDFDIFHPSLQQKNTLLPLSLYIQSWRKRY", "length": 333 }, "evidence": [ { "id": "A7YVD7", "url": "https://omabrowser.org/oma/group/A7YVD7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RY58-1", "protein_name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6", "gene_name": "NDUFAF6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAASMLGSAWGPLRLGLPGLCRRRPPGGLWARARRLPGSAGSGRSVAAASGSGASGTDRYCMELLRKRDYEGYLCSLLFPAESRSSAFALRAFNVELAQVKDSVSEKTIGLMRMQFWKKTVDDIYCDSPPHQPVAIELWKAVKRHNLTKRWLMKIIDEREKNLDDKAYRNIQELENYAENTQSSLLYLTLEILGVKDLHADHAASHIGKAQGIVTCLRATPYHGSRRRVFLPMDICMLHGVSQEDFLRKSQDKNVRDVVYDIASQAHLHLKHARSFHKSVPAKAFPAFLQTVALEDYLKKIQQVDFDIFHPSLQQKNTLLPLSVYIQSWRKRY", "length": 333 }, "evidence": [ { "id": "A7YVD7", "url": "https://omabrowser.org/oma/group/A7YVD7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q330K2-1", "protein_name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6", "gene_name": "NDUFAF6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAASAHGSVWGPLRLGIPGLCCRRPPLGLYARMRRLPGPEVSGRSVAAASGPGAWGTDHYCLELLRKRDYEGYLCSLLLPAESRSSVFALRAFNVELAQVKDSVSEKTIGLMRMQFWKKTVEDIYCDNPPHQPVAIELWKAVKRHNLTKRWLMKIVDEREKNLDDKAYRNIKELENYAENTQSSLLYLTLEILGIKDLHADHAASHIGKAQGIVTCLRATPYHGSRRKVFLPMDICMLHGVSQEDFLRRNQDKNVRDVIYDIASQAHLHLKHARSFHKTVPVKAFPAFLQTVSLEDFLKKIQRVDFDIFHPSLQQKNTLLPLYLYIQSWRKTY", "length": 333 }, "evidence": [ { "id": "A7YVD7", "url": "https://omabrowser.org/oma/group/A7YVD7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54E48-1", "protein_name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIRNSGRILFNSLKNSNVKLINRNVIINSNIRLFSTSTNNTIKESVEKKAETISNKDNIASPSSKSIDVSDLAGNADYNFVFERIKTCDKENYINSLLISDPIARRVAYAIRAFNIETVANDHSPKSEKISRLRLSFWKDAINNIYNGKVYDQPLTRVLAQVIKEKKLTKTWFIKILNRREKDNQQVQIKDMEELEQYADDIHSSLMLLTLEGLGVKGNHDVEHCASHLGKAIGIMVLIRGTVYHLASRKTYIPVSLTTKYGINVESLYRGDPQIEKLQNAIYEMASCAKLHLDKAKQFRGKIPHPATEAFLSVSVVEDFLERLRKADFNIFEFPNTQQHPLLLIKLYKNKFFKQF", "length": 356 }, "evidence": [ { "id": "A7YVD7", "url": "https://omabrowser.org/oma/group/A7YVD7/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9SI77-1", "protein_name": "Terpenoid synthases superfamily protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MNGGGSSSLRSALSYCVQQVRNYDYHHYLCLLELPTEMRKAAFALRAFNVETARAMDVASDPKIGLMRLLWWQEAIDKLYTKKPINHPAAQALSWAISEHNISKPWLKRSVDARIRDAQREVDDIPESIAELEKYAEDTVSTLLYNTLQAGGISSTTADHAASHIGKASGLVLLLKSLPYHCTRNRHQSYIPADLAEKHGLLVKQGGRLEILLDNDSREGLSNVVFEIASVANAHLLKARELAGKVPAEAKPVLLHSVPVQVLLDSLNKVQFDVFDPRIQRGVLGVPPLLFQFKLKWYSWRAMF", "length": 304 }, "evidence": [ { "id": "A7YVD7", "url": "https://omabrowser.org/oma/group/A7YVD7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VYS5-1", "protein_name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog", "gene_name": "sicily", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MRRLVRNWNCRLLFNAKSGQEIVSHAGIHQEAKTNAIPREKKVIEADKNGYGAKHCMSLVEKYDYENYLCTLLLPRELRRAAFALRAFNVEVSRSVSGHQIEPQIAKMRLKFWHDSIDKCFEPDSQRSYVEDQPVLRELKHTVGSRKLNKVYLRRLVTARERPPTHAFESIRELEEYTEQTFSSLLLLLLEVGGVRDLNADHAASHLGKAQGIATLLRSIPLAGRQQAPCIPLEVLVLHGVSQERIIRSKSDDKGVEDCIFDVASAANTHLKLARQLHDKVPPQVRKIFLSAVATDAYLERLRRANFLLTHKSCVGRDTLLPARLFWKSLLNRF", "length": 334 }, "evidence": [ { "id": "A7YVD7", "url": "https://omabrowser.org/oma/group/A7YVD7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A7YVD7", "url": "https://www.uniprot.org/uniprotkb/A7YVD7" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A7YVD7", "url": "https://www.uniprot.org/uniprotkb/A7YVD7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "A7YVD7", "url": "https://www.uniprot.org/uniprotkb/A7YVD7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7YVD7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 333, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7YVD7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7YVD7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 146, "end_pos": 148 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B9Z2-1", "uniprot_ac": "E1B9Z2", "uniprot_id": "E1B9Z2_BOVIN", "mass": { "chemical_mass": 52586.0, "monoisotopic_mass": 52586.0 }, "refseq": {}, "gene_names": [ { "name": "LETM2", "type": "recommended", "evidence": [ { "id": "E1B9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Z2" } ] } ], "protein_names": [ { "name": "Leucine zipper and EF-hand containing transmembrane protein 2", "type": "synonym", "evidence": [ { "id": "E1B9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Z2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B9Z2", "url": "https://www.uniprot.org/uniprotkb/E1B9Z2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LETM2", "url": "https://www.uniprot.org/uniprotkb/E1B9Z2", "locus": {} } ], "crossref": [ { "id": "E1B9Z2", "url": "https://alphafold.ebi.ac.uk/entry/E1B9Z2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR033122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MAACGCN", "url": "https://omabrowser.org/oma/group/MAACGCN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B9Z2", "url": "https://www.orthodb.org/?gene=E1B9Z2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14009", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14009", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14009:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14009:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07766", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07766", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19324", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19324", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TTD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTD8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9Z2", "url": "https://www.uniprot.org/uniprotkb/E1B9Z2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9Z2-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Z2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFYSYKTVLAIARTRFPSHFVQPTSSSYSPSFAFLHLPDSHLNKTYMKNYGSKKYSHPSQSGNKVLHLRARIFQELHTSTCWLQEVPNKHQQEQTAKKPQVPSPQPTKEAGMKIKEGKRSYRQIIMDELKYYYNGFYLLWIDTKVAARMVWRLLHGQVLTRRERRRLLRTCADFFRLVPFMVFIIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQRKKMAAKLELAKFLQETITEMAKRNRAQLGDASTQFSSYVKQVQTGHKPSTKEIVQFSKLFEDQLTLEHLDRPQLVALCKLLELQSFGTNNLLRFQLLMRLKSIKADDEVIAKEGVNALSVSELQAACRARGMLSLGLTEGQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEAPKTDIPLGSPTPPESKENTAGLAPQLKETKQLMPPNHQEHLTQWVNLW", "length": 455, "header": "tr|E1B9Z2-1|E1B9Z2_BOVIN Isoform 1 of Leucine zipper and EF-hand containing transmembrane protein 2 OS=Bos taurus OX=9913 GN=LETM2 PE=4 SV=4 CANONICAL=E1B9Z2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TTD8-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Z2/entry#A0AAA9TTD8-1", "sequence": { "sequence": "MAFYSYKTVLAIARTRFPSHFVQPTSSSYSPSFAFLHLPDSHLNKTYMKNYGSKKYSHPSQSGNKVLHLRARIFQELHTSTCWLQEVPNKHQQEQTAKKPQVPSPQPTKEAGMKIKEGKRSYRQIIMDELKYYYNGFYLLWIDTKVAARMVWRLLHGQVLTRRERRRLLRTCADFFRLVPFMVFIIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQRKKMAAKLELAKFLQETITEMAKRNRAQLGDASTQFSSYVKQVQTGHKPSTKEIVQFSKLFEDQLTLEHLDRPQLVALCKLLELQSFGTNNLLRFQLLMRLKSIKADDEVIAKEGVNALSVSELQAACRARGMLSLGLTEGQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEAPKTDIPLGSPTPPESKENTAGLAPQLKETKAKSEKTTQNSKASSNGA", "length": 454, "header": "tr|A0AAA9TTD8-1|E1B9Z2_BOVIN Computationally mapped isoform of Leucine zipper and EF-hand containing transmembrane protein 2 OS=Bos taurus OX=9913 GN=LETM2 PE=4 SV=1 CANONICAL=E1B9Z2-1" }, "locus": { "chromosome": "27", "start_pos": 33544148, "end_pos": 33529809, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133398.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133398.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101966.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101966.1" } ] } }, { "isoform_ac": "E1B9Z2-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Z2/entry#E1B9Z2-1", "sequence": { "sequence": "MAFYSYKTVLAIARTRFPSHFVQPTSSSYSPSFAFLHLPDSHLNKTYMKNYGSKKYSHPSQSGNKVLHLRARIFQELHTSTCWLQEVPNKHQQEQTAKKPQVPSPQPTKEAGMKIKEGKRSYRQIIMDELKYYYNGFYLLWIDTKVAARMVWRLLHGQVLTRRERRRLLRTCADFFRLVPFMVFIIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQRKKMAAKLELAKFLQETITEMAKRNRAQLGDASTQFSSYVKQVQTGHKPSTKEIVQFSKLFEDQLTLEHLDRPQLVALCKLLELQSFGTNNLLRFQLLMRLKSIKADDEVIAKEGVNALSVSELQAACRARGMLSLGLTEGQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEAPKTDIPLGSPTPPESKENTAGLAPQLKETKQLMPPNHQEHLTQWVNLW", "length": 455, "header": "tr|E1B9Z2-1|E1B9Z2_BOVIN Isoform 1 of Leucine zipper and EF-hand containing transmembrane protein 2 OS=Bos taurus OX=9913 GN=LETM2 PE=4 SV=4 CANONICAL=E1B9Z2-1" }, "locus": { "chromosome": "27", "start_pos": 33548639, "end_pos": 33529809, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047384.6", "url": "https://www.ensembl.org/id/ENSBTAT00000047384.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044595.5", "url": "https://www.ensembl.org/id/ENSBTAP00000044595.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 418, "start_aa": "Thr", "end_pos": 418, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr418", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZAW9-1", "protein_name": "Leucine zipper and EF-hand containing transmembrane protein 2", "gene_name": "LETM2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MALRSWSALLALARPRPRPRGSQLLLHSISPCSPAIALVQLVDLHLNRTCVCPSQRQHRARPDPRLPHSAAEAVRSFHTSTRVLQEPQEQPAPSRGAAPAPTPTRGTESPVGRKSWHQTIVGELKHYYNGFHLLWIDTKVAARMVWRLLHGQVLTRRERRRLLRTCADLFRLVPFLVFIIVPFMEFLLPVFLKLFPEMLPSTFETESKKEEKQKKKLNAKLELAKFLQETIAEMAKRNKADTGQGKQFSSYVHQIRHTGHKPSTQEIVRFSKLFEDELTLEHLERPQLVALCKLLELQPIGTNNLLRFQLLLRLRTIRTDDELIAKEGVNGLSVSELQSACRARGMRSLGLSEEQLKEQLRQWLDLHLKENVPPSLLLLSRALYLIDVTPQSLPENKIGETEEVMTSIPEDQESLVDPAPIAQGRKNEEFIPRPTEKLPVSEAPIKPLQQETKLEASQSSKAGANGV", "length": 467 }, "evidence": [ { "id": "E1B9Z2", "url": "https://omabrowser.org/oma/group/E1B9Z2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q2VYF4-1", "protein_name": "LETM1 domain-containing protein LETM2, mitochondrial", "gene_name": "LETM2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVPFMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEAPKTDILVELPTFTESKENMVDLAPQLKGTKDEDFIQPPPVTSSPITPSTPISLPKGPITSSEEPTLQAKSQMTAQNSKASSKGA", "length": 491 }, "evidence": [ { "id": "E1B9Z2", "url": "https://omabrowser.org/oma/group/E1B9Z2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5PQQ5-1", "protein_name": "LETM1 domain-containing protein LETM2, mitochondrial", "gene_name": "Letm2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAFYSYNSFLAIFWTRLPGHSVHPPCSHFPPLAFFHLPDSHLRTAYMKNCGSRKYSYPGLTGNNKVHPLRTRLPQKLHTTCWLQNHPGKPQPEQIPEEPKATDPQPTKDDQTEVAEGKWSLRQKIIDEVKYYYNGFSLLWIDTKVAARIVWRLLHGQVLTRRERRRLLRTCADVFRLVPFVVFIIVPFMEFLIPVFLKLFPDMLPSTFESESKKEEKQKKMMGAKLEIAKFLQETMTEMAKRNRAKLDDDSSDSSQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLRRPQLVALCKLLELQAFGTNNLLRFQLLMTLRSIKADDEVIAKEGVKALSVSELQAACRARGMRSLGLTEEQLRQQLTEWLDLHLKENVPPSLLLLSRTFYLIDVKPKPIELPPSIETPKTNLGIPSSPPPESKEDITDPAPQLNGTKILQAKSQETSQNSKANSKGA", "length": 459 }, "evidence": [ { "id": "E1B9Z2", "url": "https://omabrowser.org/oma/group/E1B9Z2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TNU7-1", "protein_name": "LETM1 domain-containing protein LETM2, mitochondrial", "gene_name": "Letm2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFYSYNSFLAIFWTRLPGHSVYPSCSHFPSLAFLHLPDSHLRTAYIKNCGSRKYSYPSLTGNNKVHPLRTRLPQKLHTTCWLQHVPGKPQLEQTGKPKAASPQPTKEAKTETTEEKRSLRQKIVNELKYYYKGFSLLWIDTKVAARIVWRLLHGNALTRRERRRLLRTCADVFRLVPFMVFIIVPFMEFLIPVFLKLFPDMLPSTFESESKKEEKQKKTMAAKLEIAKFLQETMTEMARRNRAKLGDASSQLSSYVKQVQTGHKPSTKEIVRFSKLFKDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMTLKSIKADDEIIAKEGVKALSVSELQSACRARGMRSLGLTEEQLCQQLTGWLDLHLKENVPPSLLLLSRTFYLIDVKPKPIELPPNIETPKPNLGIPTPPPPESKENLTDSAPQLKGTKDEEFIQLPPVPSSLIAPAATISKEAILQAKSQETSQNSKADSKGA", "length": 480 }, "evidence": [ { "id": "E1B9Z2", "url": "https://omabrowser.org/oma/group/E1B9Z2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "E1B9Z2", "url": "https://www.uniprot.org/uniprotkb/E1B9Z2" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1B9Z2", "url": "https://www.uniprot.org/uniprotkb/E1B9Z2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "E1B9Z2", "url": "https://www.uniprot.org/uniprotkb/E1B9Z2" } ], "pmid": "" }, { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "E1B9Z2", "url": "https://www.uniprot.org/uniprotkb/E1B9Z2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitochondrion organization", "id": "GO:0007005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007005", "evidence": [ { "database": "UniProtKB", "id": "E1B9Z2", "url": "https://www.uniprot.org/uniprotkb/E1B9Z2" } ], "pmid": "" }, { "name": "mitochondrial calcium ion transmembrane transport", "id": "GO:0006851", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006851", "evidence": [ { "database": "UniProtKB", "id": "E1B9Z2", "url": "https://www.uniprot.org/uniprotkb/E1B9Z2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Z2" }, { "id": "PS51758", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51758" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Letm1 RBD", "eco_id": "ECO_0000259", "start_pos": 221, "end_pos": 438, "start_aa": "Lys", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 418 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 44, "end_pos": 46 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BCW0-1", "uniprot_ac": "E1BCW0", "uniprot_id": "E1BCW0_BOVIN", "mass": { "chemical_mass": 78718.0, "monoisotopic_mass": 78718.0 }, "refseq": {}, "gene_names": [ { "name": "HGFAC", "type": "recommended", "evidence": [ { "id": "E1BCW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW0" } ] } ], "protein_names": [ { "name": "Serine protease HGFAC", "type": "recommended", "evidence": [ { "id": "E1BCW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Serine protease that hydrolyzes the inactive zymogen hepatocyte growth factor (HGFsc) to an activated disulfide-linked heterodimer, then initiating hepatocyte growth factor receptor signaling pathway.", "evidence": [ { "database": "UniProtKB", "id": "E1BCW0", "url": "https://www.uniprot.org/uniprotkb/E1BCW0#function" }, { "database": "UniProtKB", "id": "ARBA00093411", "url": "https://www.uniprot.org/uniprotkb/ARBA00093411#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCW0", "url": "https://www.uniprot.org/uniprotkb/E1BCW0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HGFAC", "url": "https://www.uniprot.org/uniprotkb/E1BCW0", "locus": { "chromosome": "6", "start_pos": 115437171, "end_pos": 115444800, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017335", "url": "https://www.ensembl.org/id/ENSBTAG00000017335" } ] } } ], "crossref": [ { "id": "E1BCW0", "url": "https://alphafold.ebi.ac.uk/entry/E1BCW0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017335", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017335", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00061", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00061", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00062", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00062", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00108", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00108", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000001", 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"https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01428", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22967", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22967", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511269", "url": "https://www.ncbi.nlm.nih.gov/gene/511269", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR000850", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000850", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007858", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007858", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511269", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511269", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GHVEDDF", "url": "https://omabrowser.org/oma/group/GHVEDDF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7Q2", "url": "https://www.orthodb.org/?gene=E1B7Q2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23359", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23359", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF05186", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05186", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-499943", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-499943", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001098442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098442", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TUP6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUP6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUP6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUP6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7Q2", "url": "https://www.uniprot.org/uniprotkb/E1B7Q2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7Q2-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Q2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEEEESAAPAEKAIRIQRVFINLVDSYSSRNIGKFLSNCVVGASLEEITEEEEEDDENKSAMPEASMAKLKEGTFQIVGTVSKLDIPRPEFAVETYCGISQEDLLLRLLECDVIIYNITENPQQAEEAIWAVSALNEETSHFEKRKVFILVSTVMTWARSKPLDPDDSEVPFTEEDYRRRKQHPNFLDHINAEKMVLKFGKNVRKFATYVVAAGLQYGMEGGILHAFFKLAWLGEVPALPVFGDGTNVIPAIHVLDLAGVIQNIIDHVPKLRYLVAVDESVHTLEDFVKCISKSTGPGKIQKVPKENAFLTKDLTQENIDHLLVNLRMEALFVKENFNIRWFAQAGFVENINSILKEYKQSRRLLPIKICILGPPAVGKSSVAEVLAKYYKLHHIKLKDVISEAIAKLEAIITPKDVTEGGEEEGEEEEEEDNVEDAQELLEGIKESMDQNAGRLEDQYIIRFMKEKLKSMPCRNQGYILDGFPKTYDQAKDLFSQEDEEEEEEGRGKMFPYDKLIMPEFVCSLDASDEFLKERVMNLPESIVTGTHYSQDRFLRALSNYRDVNTEDETVLNYFDELEIHPIHIDVGRLEDAQNRLAIKQLIKEVGEPRNYGLTDEEKAEEERKAAEERLAREAMEEAEREHKEAVETAEKIARWEEWNKRLEEVKREERELLEAQSIPLRNYLMTYVMPTLMQGLNECCKVRPDDPVDFLAEYLFKNNPETQ", "length": 724, "header": "tr|E1B7Q2-1|E1B7Q2_BOVIN Isoform 1 of Adenylate kinase 7 OS=Bos taurus OX=9913 GN=AK7 PE=1 SV=2 CANONICAL=E1B7Q2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TUP6-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Q2/entry#A0AAA9TUP6-1", "sequence": { "sequence": "MAEEEESAAPAEKAIRIQRVFINLVDSYSSRNIGKFLSNCVVGASLEEITEEEEEDDENKSAMPEASMAKLKEGTFQIVGTVSKLDIPRPEFAVETYCVSPGGEG", "length": 105, "header": "tr|A0AAA9TUP6-1|E1B7Q2_BOVIN Computationally mapped isoform of Adenylate kinase 7 OS=Bos taurus OX=9913 GN=AK7 PE=1 SV=1 CANONICAL=E1B7Q2-1" }, "locus": { "chromosome": "21", "start_pos": 61282714, "end_pos": 61274545, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088788.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088788.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102353.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102353.1" } ] } }, { "isoform_ac": "E1B7Q2-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Q2/entry#E1B7Q2-1", "sequence": { "sequence": "MAEEEESAAPAEKAIRIQRVFINLVDSYSSRNIGKFLSNCVVGASLEEITEEEEEDDENKSAMPEASMAKLKEGTFQIVGTVSKLDIPRPEFAVETYCGISQEDLLLRLLECDVIIYNITENPQQAEEAIWAVSALNEETSHFEKRKVFILVSTVMTWARSKPLDPDDSEVPFTEEDYRRRKQHPNFLDHINAEKMVLKFGKNVRKFATYVVAAGLQYGMEGGILHAFFKLAWLGEVPALPVFGDGTNVIPAIHVLDLAGVIQNIIDHVPKLRYLVAVDESVHTLEDFVKCISKSTGPGKIQKVPKENAFLTKDLTQENIDHLLVNLRMEALFVKENFNIRWFAQAGFVENINSILKEYKQSRRLLPIKICILGPPAVGKSSVAEVLAKYYKLHHIKLKDVISEAIAKLEAIITPKDVTEGGEEEGEEEEEEDNVEDAQELLEGIKESMDQNAGRLEDQYIIRFMKEKLKSMPCRNQGYILDGFPKTYDQAKDLFSQEDEEEEEEGRGKMFPYDKLIMPEFVCSLDASDEFLKERVMNLPESIVTGTHYSQDRFLRALSNYRDVNTEDETVLNYFDELEIHPIHIDVGRLEDAQNRLAIKQLIKEVGEPRNYGLTDEEKAEEERKAAEERLAREAMEEAEREHKEAVETAEKIARWEEWNKRLEEVKREERELLEAQSIPLRNYLMTYVMPTLMQGLNECCKVRPDDPVDFLAEYLFKNNPETQ", "length": 724, "header": "tr|E1B7Q2-1|E1B7Q2_BOVIN Isoform 1 of Adenylate kinase 7 OS=Bos taurus OX=9913 GN=AK7 PE=1 SV=2 CANONICAL=E1B7Q2-1" }, "locus": { "chromosome": "21", "start_pos": 61342471, "end_pos": 61274545, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061550.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061550.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053188.2", "url": "https://www.ensembl.org/id/ENSBTAP00000053188.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structural diversity of axonemes across mammalian motile cilia.", "journal": "Nature", "date": "2025", "authors": "Leung Miguel Ricardo, Sun Chen, Zeng Jianwei, Anderson Jacob R, Niu Qingwei, Huang Wei, Noteborn Willem E M, Brown Alan, Zeev-Ben-Mordehai Tzviya, Zhang Rui", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q2", "url": "https://www.uniprot.org/uniprotkb/E1B7Q2" } ], "reference": [ { "type": "PubMed", "id": "39743588", "url": "https://glygen.org/publication/PubMed/39743588" } ] } ], "pathway": [ { "id": "bta:511269", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511269", "resource": "KEGG Pathway" }, { "id": "R-BTA-499943", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-499943", "resource": "Reactome", "description": "Interconversion of nucleotide di- and triphosphates" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LVX3-1", "protein_name": "Adenylate kinase 7", "gene_name": "Ak7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEEEVPATTEKVLKIQRVFINHLDTYSSGNIGKFLANCVAGASLEEIGEEEEEEDETKSAGAATEATTTKVKEGTFQIVGTLAKLESTRPDFAVETYSHGTSREDLLARLLECDVVVYNITENAQQVQEALWAVSALSEEISHFEKRKMFILLSTVMTWARSKPLDPDDSEVPFTEEDYRRRKHHPNFQDHINAEKLVLKFGKNAKKFVTYVVASGLQYGVEGGILHAFFKMAWLGEIPALPVFGDGSNCIPAIHVLDLAGVIQNVIDHVPKLHYLVAVDESVHTLEDLVKCISKNTGPGKIQKVPKENAFLTKDLTQEHLDQLLVNLRMEALFVKENFNIRWAAQTGFVENIGSILKEYKQSRGLLPIKICILGPPAVGKSSISGELVKYYKLHHIKIKDVISEAIAKLEAIVAPKESTEEEEGEEEEEEENVEDAQELLDGIKESMEQNAGRLEDQYVIRFVKEKLKSMPCKNQGYVLDGFPKTYDQAKDLFNQEDEEEEEEVRGKMFPYDKLITPEFVCNLDASDEFLKERVMNLPESVVAGTHYSQDRFLRALSNYRDINTDDETVFNYFDEIEIHPIHIDVGKLEDAQNRLAIKQLIKEIGEPRNYGLTDEEKAEVEKKAAEERLAKEAAQTAEREHKEALEMAEKIARWEEWSKRLEEVKREERELLEAQSIPLRNYLMTYVMPTLMQGLNECCKVRPEDPVDFLAEYLFKNNPEMQ", "length": 724 }, "evidence": [ { "id": "E1B7Q2", "url": "https://omabrowser.org/oma/group/E1B7Q2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1QF80-1", "protein_name": "2.7.4.3", "gene_name": "ak7b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAEKIDERPQNSRRVFINNVDAYTSKNIARFLDLCVVGASLVFAGEADVEEEDDRLHDDQAEIKDGTFQIVGTVSSQTEEKCSFIAEQYSHHTKREDLLHHLLKCDVIIYDVTQHADQIDEAQWAVSALYEEMDRFPAAKTFILVSTVLTWAMTKPADKDYPETPLTDSNYRRRKAHPNFHRHISLEKLVVKLGKTKSSRFSTYVVASGLQYGMEEHVFHLFFKMSWMGEVSHVPIFGDGSNIIPTIHINDLAGIIQNVIDHKPKVQYFVAVDDSKNTMEDIIKAITLMLGPGKTRNVSKEEIYLIQNLTQTEIDSLLVNLPIEAPYLKDNFNIQWVSETGMVQNIEQVIEEYKESRGLLPIRMCIVGPPAVGKSTIAEKICKHYNLHHIKLKEAIAEALENLELCVRTEDEENDQDDDQEFWDTLRENMNENGGRLDDQYVIRIMKDKLRTKPCMNQGFVLDGFPKTCEQAKELFTGDGEPEDLESKHATKIIPEFVFSVNATDDFLKNRVLNLPETVVEGTSYMPEQFLQRLARFRDRNVEDEMPLNYFEDLEIHPEHLEITSDNDNEYQLIIDKICKKVGKPRNYGPILEKVEEEKRRQVKERLNEQAAQRVEEERREEEEAQHRDQRWGEWSQHLVEVKRQELDLLESQSEPLRDYLMQDVMPTLTQGLIECCRLRPDDPIDFLAEYLLQNNPEA", "length": 699 }, "evidence": [ { "id": "E1B7Q2", "url": "https://omabrowser.org/oma/group/E1B7Q2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q96M32-1", "protein_name": "Adenylate kinase 7", "gene_name": "AK7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEEEETAALTEKVIRTQRVFINLLDSYSSGNIGKFLSNCVVGASLEEITEEEEEEDENKSAMLEASSTKVKEGTFQIVGTLSKPDSPRPDFAVETYSAISREDLLMRLLECDVIIYNITESSQQMEEAIWAVSALSEEVSHFEKRKLFILLSTVMTWARSKALDPEDSEVPFTEEDYRRRKSHPNFLDHINAEKMVLKFGKKARKFAAYVVAAGLQYGAEGGMLHTFFKMAWLGEIPALPVFGDGTNVIPTIHVLDLAGVIQNVIDHVPKPHYLVAVDESVHTLEDIVKCISKNTGPGKIQKIPRENAYLTKDLTQDCLDHLLVNLRMEALFVKENFNIRWAAQTGFVENINTILKEYKQSRGLMPIKICILGPPAVGKSSIAKELANYYKLHHIQLKDVISEAIAKLEAIVAPNDVGEGEEEVEEEEEEENVEDAQELLDGIKESMEQNAGQLDDQYIIRFMKEKLKSMPCRNQGYILDGFPKTYDQAKDLFNQEDEEEEDDVRGRMFPFDKLIIPEFVCALDASDEFLKERVINLPESIVAGTHYSQDRFLRALSNYRDINIDDETVFNYFDELEIHPIHIDVGKLEDAQNRLAIKQLIKEIGEPRNYGLTDEEKAEEERKAAEERLAREAAEEAEREHQEAVEMAEKIARWEEWNKRLEEVKREERELLEAQSIPLRNYLMTYVMPTLIQGLNECCNVRPEDPVDFLAEYLFKNNPEAQ", "length": 723 }, "evidence": [ { "id": "E1B7Q2", "url": "https://omabrowser.org/oma/group/E1B7Q2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "AMP kinase activity", "id": "GO:0004017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004017", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q2", "url": "https://www.uniprot.org/uniprotkb/E1B7Q2" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q2", "url": "https://www.uniprot.org/uniprotkb/E1B7Q2" } ], "pmid": "" }, { "name": "nucleoside diphosphate kinase activity", "id": "GO:0004550", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004550", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q2", "url": "https://www.uniprot.org/uniprotkb/E1B7Q2" } ], "pmid": "" }, { "name": "dCMP kinase activity", "id": "GO:0036431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036431", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q2", "url": "https://www.uniprot.org/uniprotkb/E1B7Q2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q2", "url": "https://www.uniprot.org/uniprotkb/E1B7Q2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q2", "url": "https://www.uniprot.org/uniprotkb/E1B7Q2" } ], "pmid": "" }, { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q2", "url": "https://www.uniprot.org/uniprotkb/E1B7Q2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 118, "end_pos": 120, "annotation": "n_glycosylation_sequon" }, { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7Q2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 724, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7Q2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7Q2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 118, "end_pos": 120 }, { "start_pos": 59, "end_pos": 61 } ] }, "class_list": [], 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"total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "E1BCN8-1", "uniprot_ac": "E1BCN8", "uniprot_id": "E1BCN8_BOVIN", "mass": { "chemical_mass": 38318.0, "monoisotopic_mass": 38318.0 }, "refseq": { "ac": "XP_024835966", "name": "phosphoethanolamine/phosphocholine phosphatase isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835966" }, "gene_names": [ { "name": "PHOSPHO1", "type": "recommended", "evidence": [ { "id": "E1BCN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCN8" } ] }, { "name": "PHOSPHO1", "type": "synonym", "evidence": [ { "id": "XP_024835966", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835966" } ] } ], "protein_names": [ { "name": "Phosphoethanolamine/phosphocholine phosphatase", "type": "recommended", "evidence": [ { "id": "E1BCN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCN8/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.75", "type": "synonym", "evidence": [ { "id": "E1BCN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCN8/entry#names_and_taxonomy" } ] }, { "name": "phosphoethanolamine/phosphocholine phosphatase isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024835966", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835966" } ] } ], "function": [ { "annotation": "Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization. Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix.", "evidence": [ { "database": "UniProtKB", "id": "E1BCN8", "url": "https://www.uniprot.org/uniprotkb/E1BCN8#function" }, { "database": "UniProtKB", "id": "ARBA00056980", "url": "https://www.uniprot.org/uniprotkb/ARBA00056980#function" }, { "database": "UniProtKB", "id": "A0AAA9TV92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV92#function" }, { "database": "UniProtKB", "id": "A0AAA9TW08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW08#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BCN8", "url": "https://www.uniprot.org/uniprotkb/E1BCN8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PHOSPHO1", "url": "https://www.uniprot.org/uniprotkb/E1BCN8", "locus": { "chromosome": "19", "start_pos": 37352752, "end_pos": 37344678, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000033", "url": "https://www.ensembl.org/id/ENSBTAG00000000033" } ] } } ], "crossref": [ { "id": "E1BCN8", "url": "https://alphafold.ebi.ac.uk/entry/E1BCN8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000033", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000033", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "3.1.3.75", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.75&UniProtAcc=E1BCN8", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd16418", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16418", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "524639", "url": "https://www.ncbi.nlm.nih.gov/gene/524639", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006384", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006384", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BCN8", "url": "https://www.orthodb.org/?gene=E1BCN8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20889", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20889", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20889:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20889:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06888", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06888", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1483191", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483191", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1483213", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483213", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024835966", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835966", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10492", "url": "https://www.rhea-db.org/rhea/10492", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "16089", "url": "https://www.rhea-db.org/rhea/16089", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TV92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV92-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW08-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCN8", "url": "https://www.uniprot.org/uniprotkb/E1BCN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCN8-1", "url": "https://www.uniprot.org/uniprotkb/E1BCN8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGCFPVAGLRCLSRVCRGLVREAPTSPSPTASPAARLLRTLAETPSADKFLPGNWSSMCQHLWPWPANLPLLGRLLPRPLSLAPSSSCSSLPCSQDGGMAAQGSPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLRATYREGFYNEYMQRVFQYLGDQGVRPRDLRAVYESIPLSPGMGELLQFVAKQGSCFEVILISDANTFGVESALRAAGHQGLFRRIFSNPSGPDARGLLALRPFHSHSCARCPANMCKHKVLSDYLRERAHDGVHFERLFYVGDGANDFCPVGLLAGGDVAFPRRGYPMHRLIQEAQKAEPSSFRASVVPWENAIEVRLHLQQVLKTC", "length": 348, "header": "tr|E1BCN8-1|E1BCN8_BOVIN Isoform 1 of Phosphoethanolamine/phosphocholine phosphatase OS=Bos taurus OX=9913 GN=PHOSPHO1 PE=3 SV=2 CANONICAL=E1BCN8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TV92-1", "url": "https://www.uniprot.org/uniprotkb/E1BCN8/entry#A0AAA9TV92-1", "sequence": { "sequence": "MAAQGSPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLRATYREGFYNEYMQRVFQYLGDQGVRPRDLRAVYESIPLSPGMGELLQFVAKQGSCFEVILISDANTFGVESALRAAGHQGLFRRIFSNPSGPDARGLLALRPFHSHSCARCPANMCKHKVLSDYLRERAHDGVHFERLFYVGDGANDFCPVGLLAGGDVAFPRRGYPMHRLIQEAQKAEPSSFRASVVPWENAIEVRLHLQQVLKTC", "length": 249, "header": "tr|A0AAA9TV92-1|E1BCN8_BOVIN Computationally mapped isoform of Phosphoethanolamine/phosphocholine phosphatase OS=Bos taurus OX=9913 GN=PHOSPHO1 PE=3 SV=1 CANONICAL=E1BCN8-1" }, "locus": { "chromosome": "19", "start_pos": 37350725, "end_pos": 37349979, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102424.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102424.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101320.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101320.1" } ] } }, { "isoform_ac": "A0AAA9TW08-1", "url": "https://www.uniprot.org/uniprotkb/E1BCN8/entry#A0AAA9TW08-1", "sequence": { "sequence": "MCQHLWPWPANLPLLGRLLPRPLSLAPSSSCSSLPCSQDGGMAAQGSPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLRATYREGFYNEYMQRVFQYLGDQGVRPRDLRAVYESIPLSPGMGELLQFVAKQGSCFEVILISDANTFGVESALRAAGHQGLFRRIFSNPSGPDARGLLALRPFHSHSCARCPANMCKHKVLSDYLRERAHDGVHFERLFYVGDGANDFCPVGLLAGGDVAFPRRGYPMHRLIQEAQKAEPSSFRASVVPWENAIEVRLHLQQVLKTC", "length": 290, "header": "tr|A0AAA9TW08-1|E1BCN8_BOVIN Computationally mapped isoform of Phosphoethanolamine/phosphocholine phosphatase OS=Bos taurus OX=9913 GN=PHOSPHO1 PE=3 SV=1 CANONICAL=E1BCN8-1" }, "locus": { "chromosome": "19", "start_pos": 37350725, "end_pos": 37349856, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110252.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110252.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098019.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098019.1" } ] } }, { "isoform_ac": "E1BCN8-1", "url": "https://www.uniprot.org/uniprotkb/E1BCN8/entry#E1BCN8-1", "sequence": { "sequence": "MSGCFPVAGLRCLSRVCRGLVREAPTSPSPTASPAARLLRTLAETPSADKFLPGNWSSMCQHLWPWPANLPLLGRLLPRPLSLAPSSSCSSLPCSQDGGMAAQGSPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLRATYREGFYNEYMQRVFQYLGDQGVRPRDLRAVYESIPLSPGMGELLQFVAKQGSCFEVILISDANTFGVESALRAAGHQGLFRRIFSNPSGPDARGLLALRPFHSHSCARCPANMCKHKVLSDYLRERAHDGVHFERLFYVGDGANDFCPVGLLAGGDVAFPRRGYPMHRLIQEAQKAEPSSFRASVVPWENAIEVRLHLQQVLKTC", "length": 348, "header": "tr|E1BCN8-1|E1BCN8_BOVIN Isoform 1 of Phosphoethanolamine/phosphocholine phosphatase OS=Bos taurus OX=9913 GN=PHOSPHO1 PE=3 SV=2 CANONICAL=E1BCN8-1" }, "locus": { "chromosome": "19", "start_pos": 37350725, "end_pos": 37348167, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000037.4", "url": "https://www.ensembl.org/id/ENSBTAT00000000037.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000037.3", "url": "https://www.ensembl.org/id/ENSBTAP00000000037.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 31, "start_aa": "Thr", "end_pos": 31, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr31", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-1483191", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483191", "resource": "Reactome", "description": "Synthesis of PC" }, { "id": "R-BTA-1483213", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483213", "resource": "Reactome", "description": "Synthesis of PE" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BCN8", "url": "https://www.uniprot.org/uniprotkb/E1BCN8" } ], "pmid": "" }, { "name": "phosphatase activity", "id": "GO:0016791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016791", "evidence": [ { "database": "UniProtKB", "id": "E1BCN8", "url": "https://www.uniprot.org/uniprotkb/E1BCN8" } ], "pmid": "" }, { "name": "pyrophosphatase activity", "id": "GO:0016462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016462", "evidence": [ { "database": "UniProtKB", "id": "E1BCN8", "url": "https://www.uniprot.org/uniprotkb/E1BCN8" } ], "pmid": "" }, { "name": "phosphocholine phosphatase activity", "id": "GO:0052731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052731", "evidence": [ { "database": "UniProtKB", "id": "E1BCN8", "url": "https://www.uniprot.org/uniprotkb/E1BCN8" } ], "pmid": "" }, { "name": "phosphoethanolamine phosphatase activity", "id": "GO:0052732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052732", "evidence": [ { "database": "UniProtKB", "id": "E1BCN8", "url": "https://www.uniprot.org/uniprotkb/E1BCN8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular vesicle", "id": "GO:1903561", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903561", "evidence": [ { "database": "UniProtKB", "id": "E1BCN8", "url": "https://www.uniprot.org/uniprotkb/E1BCN8" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "E1BCN8", "url": "https://www.uniprot.org/uniprotkb/E1BCN8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of bone mineralization", "id": "GO:0030500", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030500", "evidence": [ { "database": "UniProtKB", "id": "E1BCN8", "url": "https://www.uniprot.org/uniprotkb/E1BCN8" } ], "pmid": "" }, { "name": "bone mineralization involved in bone maturation", "id": "GO:0035630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035630", "evidence": [ { "database": "UniProtKB", "id": "E1BCN8", "url": "https://www.uniprot.org/uniprotkb/E1BCN8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 55, "end_pos": 57, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10492", "name": "", "equation": "phosphocholine + H2O = choline + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BCN8-1" ], "evidence": [ { "id": "10492", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10492" } ] }, { "id": "16089", "name": "", "equation": "phosphoethanolamine + H2O = ethanolamine + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P09487-1", "E1BCN8-1" ], "evidence": [ { "id": "16089", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16089" } ] }, { "id": "R-BTA-1483096", "name": "PETA is dephosphorylated to ETA by PHOSPHO1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BCN8-1" ], "evidence": [ { "id": "R-BTA-1483096", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483096" } ] }, { "id": "R-BTA-1483159", "name": "PCho is dephosphorylated to Cho by PHOSPHO1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BCN8-1" ], "evidence": [ { "id": "R-BTA-1483159", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483159" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "E1BCN8", "gene_name": "PHOSPHO1", "activity": [ { "ec_number": "3.1.3.75", "activity": "phosphocholine + H2O = choline + phosphate.", "evidence": [ { "id": "E1BCN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCN8" } ] }, { "ec_number": "3.1.3.75", "activity": "", "evidence": [ { "id": "E1BCN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCN8" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BCN8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 348, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BCN8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BCN8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "A0AAA9TV92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV92#function" }, { "id": "A0AAA9TV92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV92" }, { "id": "PIRSR031051-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR031051-3" } ], "binding_site_uniprot": 14, "amino_acid": "Ser", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 14, "end_pos": 14, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TV92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV92#function" }, { "id": "A0AAA9TV92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV92" }, { "id": "PIRSR031051-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR031051-3" } ], "binding_site_uniprot": 16, "amino_acid": "Val", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 16, "end_pos": 16, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TV92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV92#function" }, { "id": "A0AAA9TV92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV92" }, { "id": "PIRSR031051-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR031051-3" } ], "binding_site_uniprot": 185, "amino_acid": "Glu", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 185, "end_pos": 185, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TW08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW08#function" }, { "id": "A0AAA9TW08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW08" }, { "id": "PIRSR031051-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR031051-3" } ], "binding_site_uniprot": 226, "amino_acid": "Ile", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 226, "end_pos": 226, "start_aa": "Ile", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TW08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW08#function" }, { "id": "A0AAA9TW08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW08" }, { "id": "PIRSR031051-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR031051-3" } ], "binding_site_uniprot": 55, "amino_acid": "Asn", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 55, "end_pos": 55, "start_aa": "Asn", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TW08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW08#function" }, { "id": "A0AAA9TW08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW08" }, { "id": "PIRSR031051-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR031051-3" } ], "binding_site_uniprot": 57, "amino_acid": "Ser", "chebi_lig_id": "CHEBI_18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 57, "end_pos": 57, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.75", "ec_name": "phosphocholine + H2O = choline + phosphate.", "evidence": [ { "id": "3.1.3.75", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.75" }, { "id": "3.1.3.75", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.75" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 31 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 55, "end_pos": 57 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", 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"sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BC23-1", "uniprot_ac": "E1BC23", "uniprot_id": "E1BC23_BOVIN", "mass": { "chemical_mass": 78403.0, "monoisotopic_mass": 78403.0 }, "refseq": { "ac": "XP_005206997", "name": "solute carrier organic anion transporter family member 1C1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206997" }, "gene_names": [ { "name": "SLCO1C1", "type": "recommended", "evidence": [ { "id": "E1BC23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC23" } ] }, { "name": "SLCO1C1", "type": "synonym", "evidence": [ { "id": "XP_005206997", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206997" } ] } ], "protein_names": [ { "name": "Solute carrier organic anion transporter family member", "type": "recommended", "evidence": [ { "id": "E1BC23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC23/entry#names_and_taxonomy" } ] }, { "name": "solute carrier organic anion transporter family member 1C1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005206997", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206997" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BC23", "url": "https://www.uniprot.org/uniprotkb/E1BC23" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLCO1C1", "url": "https://www.uniprot.org/uniprotkb/E1BC23", "locus": { "chromosome": "5", "start_pos": 89018636, "end_pos": 89088831, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019602", "url": "https://www.ensembl.org/id/ENSBTAG00000019602" } ] } } ], "crossref": [ { "id": "E1BC23", "url": "https://alphafold.ebi.ac.uk/entry/E1BC23", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019602", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019602", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17459", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17459", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "518047", "url": "https://www.ncbi.nlm.nih.gov/gene/518047", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ISYDKHP", "url": "https://omabrowser.org/oma/group/ISYDKHP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BC23", "url": "https://www.orthodb.org/?gene=E1BC23", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11388", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11388", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11388:SF99", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11388:SF99", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03137", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03137", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07648", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07648", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-879518", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-879518", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005206997", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206997", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "71815", "url": "https://www.rhea-db.org/rhea/71815", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "71819", "url": "https://www.rhea-db.org/rhea/71819", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "73311", "url": "https://www.rhea-db.org/rhea/73311", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TWQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC23", "url": "https://www.uniprot.org/uniprotkb/E1BC23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC23-1", "url": "https://www.uniprot.org/uniprotkb/E1BC23-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDTSSKENIRLFSKNSMQPVGRLSFQTEYPSPEEKQPCCGQLKVFLGALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGIIDGSFEIGNLLVIAFVSYFGAKLHRPKIIGAGCLIMGVGTLLIAMPQFFMEHYKYERYSPVSNSTLSISPCLLDSNNSLPIPVAEKSQSKINNECQIDASSSMWVYVFLGNLLRGFGETPIQPLGIAYLDDFASQDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGSITLLAAVPFWCLPRTLPRPRSREDSSSSSEKSKFIMDDHTDYQTPPGEKAKIMEMARDFLPSLKSLFGNPVYFLYLCASTVQFNSLFGMVTYKPKYIEQQYGQSASKANFVIGLINIPAVALGIFSGGIVMKKFRISICGAAKLYLGSSVLGYLLFLSLFALGCENSDVAGLTISYQGTKPVSYHERALFSDCNSRCKCSETKWEPICGENGITYASACLAGCQTTTGSGKTTVFNNCTCVGLAASKSGNSTGMVGRCQKDNGCAKMFLYFLVIAVITSYTLSVGGIPGYILLLRCIKPQLKSFALGIYTLAVRVLAGIPSPIYFGVLIDTSCLKWGFKRCGSKGSCRLYDSNAFRHIYLGLTMMLGIMSIFLSTAVLFTLKKNYVSKHRSFRTKRERTMVSTRIRKENCTTSDHLLQPNYWPGKETQL", "length": 712, "header": "tr|E1BC23-1|E1BC23_BOVIN Isoform 1 of Solute carrier organic anion transporter family member OS=Bos taurus OX=9913 GN=SLCO1C1 PE=3 SV=3 CANONICAL=E1BC23-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TWQ0-1", "url": "https://www.uniprot.org/uniprotkb/E1BC23/entry#A0AAA9TWQ0-1", "sequence": { "sequence": "MDTSSKENIRLFSKNSMQPVGRLSFQTEYPSPEEKQPCCGQLKVFLGALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGIIDGSFEIGNLLVIAFVSYFGAKLHRPKIIGAGCLIMGVGTLLIAMPQFFMEHYKYERYSPVSNSTLSISPCLLDSNNSLPIPVAEKSQSKINNGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGSITLLAAVPFWCLPRTLPRPRSREDSSSSSEKSKFIMDDHTDYQTPPGEKAKIMEMARDFLPSLKSLFGNPVYFLYLCASTVQFNSLFGMVTYKPKYIEQQYGQSASKANFVIGLINIPAVALGIFSGGIVMKKFRISICGAAKLYLGSSVLGYLLFLSLFALGCENSDVAGLTISYQGTKPVSYHERALFSDCNSRCKCSETKWEPICGENGITYASACLAGCQTTTGSGKTTVFNNCTCVGLAASKSGNSTGMVGRCQKDNGCAKMFLYFLVIAVITSYTLSVGGIPGYILLLRCIKPQLKSFALGIYTLAVRVLAGIPSPIYFGVLIDTSCLKWGFKRCGSKGSCRLYDSNAFRHIYLGLTMMLGIMSIFLSTAVLFTLKKNYVSKHRSFRTKRERTMVSTRIRKENCTTSDHLLQPNYWPGKETQL", "length": 663, "header": "tr|A0AAA9TWQ0-1|E1BC23_BOVIN Computationally mapped isoform of Solute carrier organic anion transporter family member OS=Bos taurus OX=9913 GN=SLCO1C1 PE=3 SV=1 CANONICAL=E1BC23-1" }, "locus": { "chromosome": "5", "start_pos": 89088831, "end_pos": 89019017, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134827.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134827.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101891.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101891.1" } ] } }, { "isoform_ac": "E1BC23-1", "url": "https://www.uniprot.org/uniprotkb/E1BC23/entry#E1BC23-1", "sequence": { "sequence": "MDTSSKENIRLFSKNSMQPVGRLSFQTEYPSPEEKQPCCGQLKVFLGALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGIIDGSFEIGNLLVIAFVSYFGAKLHRPKIIGAGCLIMGVGTLLIAMPQFFMEHYKYERYSPVSNSTLSISPCLLDSNNSLPIPVAEKSQSKINNECQIDASSSMWVYVFLGNLLRGFGETPIQPLGIAYLDDFASQDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGSITLLAAVPFWCLPRTLPRPRSREDSSSSSEKSKFIMDDHTDYQTPPGEKAKIMEMARDFLPSLKSLFGNPVYFLYLCASTVQFNSLFGMVTYKPKYIEQQYGQSASKANFVIGLINIPAVALGIFSGGIVMKKFRISICGAAKLYLGSSVLGYLLFLSLFALGCENSDVAGLTISYQGTKPVSYHERALFSDCNSRCKCSETKWEPICGENGITYASACLAGCQTTTGSGKTTVFNNCTCVGLAASKSGNSTGMVGRCQKDNGCAKMFLYFLVIAVITSYTLSVGGIPGYILLLRCIKPQLKSFALGIYTLAVRVLAGIPSPIYFGVLIDTSCLKWGFKRCGSKGSCRLYDSNAFRHIYLGLTMMLGIMSIFLSTAVLFTLKKNYVSKHRSFRTKRERTMVSTRIRKENCTTSDHLLQPNYWPGKETQL", "length": 712, "header": "tr|E1BC23-1|E1BC23_BOVIN Isoform 1 of Solute carrier organic anion transporter family member OS=Bos taurus OX=9913 GN=SLCO1C1 PE=3 SV=3 CANONICAL=E1BC23-1" }, "locus": { "chromosome": "5", "start_pos": 89088831, "end_pos": 89019017, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026117.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026117.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026117.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026117.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-879518", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-879518", "resource": "Reactome", "description": "Organic anion transport by SLCO transporters" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7H6L9-1", "protein_name": "Solute carrier organic anion transporter family member", "gene_name": "Slco1c1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDTSSKKNSHLFHKTPARPVRRQSLKVGCPSPEEARPCCGELKVFLGALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGIIDGSFEIGNLLVITFVSYFGSRLHRPKIIGAGCLVMGVGTMLIAMPQFFMEKYRYEKYEKYSPSSNLTPNVSPCHLELSSLSPSSVMGKSQNKINDECEGDASSSMWVYVFLGNLLRGLGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGLLSLLAAVPFWCLPKTLPRSQGREDPGSSSEKSKFIIDDPISYQMAPGEEMKMVEMARNFLPSLKTLLRNPVYILYLCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFFIGLINIPAVALGIFSGGIVMKKFRLGVFEATKLYLGSSVFGYLLFLSLFALGCENPGVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSESKWEPMCGDNGITYVSACLAGCQSSSQSGKNIIFSNCTCVGLAAPTSGNWSGMMGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIQPQLKSFALGIYTLAVRVLAGIPAPVYFGVLIDTSCLKWGFKKCGSRGSCRLYDSHAFRHIYLGLTTLLGTVSIFLSMAVLFVLKRKYVSKHSSFITTRDKAVVSSTFRKETSVARVHVPQPKYWPGKETRL", "length": 715 }, "evidence": [ { "id": "E1BC23", "url": "https://omabrowser.org/oma/group/E1BC23/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1NQ63-1", "protein_name": "Solute carrier organic anion transporter family member", "gene_name": "SLCO1C1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEISSKENAQLFSNNAVLPVDRSSFKSESSTSKEKQSCCGGIKIFLGALSFVYFAKALSGSYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLIIVFVSYFGAKLHRPRIIGAGCLIMSAGTFLIAMPQFFMGRYQYERFPSTINSTVSISPCLQEKSQTPLSALEKSQAKVNAGCEKAGSSMWIYVFLGNLLRGIGETPIQPLGITYIDDYAIEENAALYIGCVQTLAIIGPIFGFLLGSLCAKLYVDIGFVDLDSITITHKDVQWVGAWWLGYLIAGVISVLAGIPFWFLPKHLPKPESRKDSSTSSEQSKFITQDNKEQQKSYQPQMKVAEMAKDFLPSLKNLFGNPVYSLFLCASILHFNSLIGMVTYKPKYIEQQYGQTSSKTNFVIGLINIPAVAFGIFSGGLIMKKFRINVLGAAKISLGSSFFGYLLLLSLFAMGCENSDVAGLTVSYHGTKQKVGYEQGLFSECNLGCMCSQNDWDPICGENGITYISACLAGCQASNGSGKNTVFFNCSCVGIMASPSRSSSAVMGPCQKGNECPKMFLYFLVISVITSYTLSVGGTPGYILLLRCIKPHLKSFALGIYTLAIRVLAGIPAPVYFGVAIDTTCLKWGRKRCGGRGACRLYDSSALRYVYLGLTLVLGTVSIFFSIAVLWVLRKRSALQDETLSANGERDTCVTKSRKDNFVNSDHLIQTTYWPEKETRL", "length": 710 }, "evidence": [ { "id": "E1BC23", "url": "https://omabrowser.org/oma/group/E1BC23/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9EPZ7-1", "protein_name": "Solute carrier organic anion transporter family member 1C1", "gene_name": "Slco1c1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDTSSKENAHLFHKNSAQPAGGPSFKAGYPSTEEARPCCGKLKVFLGALSFVYFAKALTEGYLKSTITQIERRFDIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGFGTMLIAVPQFFMEKYSYEKYERYSPSSNLTPNISPCYLESSSPSPRSIVGKSQNKINDECEVDTSSSMWVYVFLGNLLRGLGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGFLSLLAAVPFWCLPKTLPRSQSREDSGSSSEKSKFITDDPVNYQMAPREESMKIMEMARDFLPSLKSLFRNPVYILYLCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLLFLSLFALGCENSSVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYASACLAGCQSSSRSGKNIIFSNCTCVGFAAPKSGNWSGMMGRCQKDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLRCIQPQLKSFALGIYTLAVRVLAGIPAPVYFGVLIDTSCLKWGFKKCGSRGSCRLYDSHAFRHIYLGLTTLLGTVSVFLSTAVLLVLKKKYVSKRSSFITAREKIVMSSSVKKETCAARDHGLQPKYWPGKETRL", "length": 716 }, "evidence": [ { "id": "E1BC23", "url": "https://omabrowser.org/oma/group/E1BC23/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9ERB5-1", "protein_name": "Solute carrier organic anion transporter family member 1C1", "gene_name": "Slco1c1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDTSSKENAHLFHKNSAQPAGGPSFTVGYPSTEEARPCCGKLKVFLGALSFVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGFGTMLIAVPQFFMEKYSYEKYERYSPSSNVTPSISPCYLESSSPSPSSILGKSQNKISHECVGDSSSSMWVYVFLGNLLRGLGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGFLSLLAAVPFWCLPKTLPRSQSRENSGSTSEKSKFIDDPIHYQMAPGDDKMKIMEMAKDFLPSLKTLFRNPVYILYLCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLLFLSLFALGCENSSVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQSSSRSGKNIIFSNCTCVGFAAPKSGNWSGMMGRCQKDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLRCIQPQLKSFALGIYTLAVRVLAGIPAPVYFGVLIDTSCLKWGFKKCGSRGSCRLYDSHAFRHIYLGLTTLLGTVSVFLSMAVLFVLKKKYVSKHSSLITTREKIGMSSSIKKETCAARDRGLQPKYWPGKETRL", "length": 715 }, "evidence": [ { "id": "E1BC23", "url": "https://omabrowser.org/oma/group/E1BC23/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NYB5-1", "protein_name": "Solute carrier organic anion transporter family member 1C1", "gene_name": "SLCO1C1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDTSSKENIQLFCKTSVQPVGRPSFKTEYPSSEEKQPCCGELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYERYSPSSNSTLSISPCLLESSSQLPVSVMEKSKSKISNECEVDTSSSMWIYVFLGNLLRGIGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPRSQSREDSNSSSEKSKFIIDDHTDYQTPQGENAKIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVFRHIYLGLTVILGTVSILLSIAVLFILKKNYVSKHRSFITKRERTMVSTRFQKENYTTSDHLLQPNYWPGKETQL", "length": 712 }, "evidence": [ { "id": "E1BC23", "url": "https://omabrowser.org/oma/group/E1BC23/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "monoatomic ion transport", "id": "GO:0006811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006811", "evidence": [ { "database": "UniProtKB", "id": "E1BC23", "url": "https://www.uniprot.org/uniprotkb/E1BC23" } ], "pmid": "" }, { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "E1BC23", "url": "https://www.uniprot.org/uniprotkb/E1BC23" } ], "pmid": "" }, { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "E1BC23", "url": "https://www.uniprot.org/uniprotkb/E1BC23" } ], "pmid": "" }, { "name": "bile acid and bile salt transport", "id": "GO:0015721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015721", "evidence": [ { "database": "UniProtKB", "id": "E1BC23", "url": "https://www.uniprot.org/uniprotkb/E1BC23" } ], "pmid": "" }, { "name": "sodium-independent organic anion transport", "id": "GO:0043252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043252", "evidence": [ { "database": "UniProtKB", "id": "E1BC23", "url": "https://www.uniprot.org/uniprotkb/E1BC23" } ], "pmid": "" }, { "name": "positive regulation of thyroid hormone generation", "id": "GO:2000611", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000611", "evidence": [ { "database": "UniProtKB", "id": "E1BC23", "url": "https://www.uniprot.org/uniprotkb/E1BC23" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "E1BC23", "url": "https://www.uniprot.org/uniprotkb/E1BC23" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "bile acid transmembrane transporter activity", "id": "GO:0015125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015125", "evidence": [ { "database": "UniProtKB", "id": "E1BC23", "url": "https://www.uniprot.org/uniprotkb/E1BC23" } ], "pmid": "" }, { "name": "thyroid hormone transmembrane transporter activity", "id": "GO:0015349", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015349", "evidence": [ { "database": "UniProtKB", "id": "E1BC23", "url": "https://www.uniprot.org/uniprotkb/E1BC23" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 520, "end_pos": 522, "annotation": "n_glycosylation_sequon" }, { "start_pos": 533, "end_pos": 535, "annotation": "n_glycosylation_sequon" }, { "start_pos": 692, "end_pos": 694, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "71815", "name": "", "equation": "3,3',5'-triiodo-L-thyronine(out) = 3,3',5'-triiodo-L-thyronine(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "71815", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/71815" } ] }, { "id": "71819", "name": "", "equation": "L-thyroxine(out) = L-thyroxine(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "71819", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/71819" } ] }, { "id": "73311", "name": "", "equation": "L-thyroxine sulfate(out) = L-thyroxine sulfate(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "73311", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/73311" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BC23-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 712, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BC23-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BC23" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BC23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC23" }, { "id": "PS51465", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51465" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kazal-like", "eco_id": "ECO_0000259", "start_pos": 470, "end_pos": 525, "start_aa": "Arg", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1BC23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC23" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 45, "end_pos": 668, "start_aa": "Phe", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 146, "end_pos": 148 }, { "start_pos": 159, "end_pos": 161 }, { "start_pos": 520, "end_pos": 522 }, { "start_pos": 533, "end_pos": 535 }, { "start_pos": 692, "end_pos": 694 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BBZ1-1", "uniprot_ac": "E1BBZ1", "uniprot_id": "E1BBZ1_BOVIN", "mass": { "chemical_mass": 34981.0, "monoisotopic_mass": 34981.0 }, "refseq": {}, "gene_names": [ { "name": "MXD3", "type": "recommended", "evidence": [ { "id": "E1BBZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBZ1" } ] } ], "protein_names": [ { "name": "Max dimerization protein 3", "type": "recommended", "evidence": [ { "id": "E1BBZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBZ1/entry#names_and_taxonomy" } ] }, { "name": "Max-associated protein 3", "type": "synonym", "evidence": [ { "id": "E1BBZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBZ1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ1#function" }, { "database": "UniProtKB", "id": "ARBA00054996", "url": "https://www.uniprot.org/uniprotkb/ARBA00054996#function" }, { "database": "UniProtKB", "id": "A0AAA9TX61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX61#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BBZ1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MXD3", "url": "https://www.uniprot.org/uniprotkb/E1BBZ1", "locus": { "chromosome": "7", "start_pos": 38778841, "end_pos": 38784511, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005010", "url": "https://www.ensembl.org/id/ENSBTAG00000005010" } ] } } ], "crossref": [ { "id": "E1BBZ1", "url": "https://alphafold.ebi.ac.uk/entry/E1BBZ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005010", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005010", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18932", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18932", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BBZ1", "url": "https://www.orthodb.org/?gene=E1BBZ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11969", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11969", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11969:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11969:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TX61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TX61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX61-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBZ1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBZ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPVASNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPVHRRRKRSPQAPGALDSGRSVHNELEKRRRAQLKRCLEQLKQQMPLGADCVRYTTLSLLRRARMHIQKLEEQEQRARQLKEKLRSKQQSLRRQLEQLRGLGTVGERERLRADSLDSSGLSSERSDSDQGKCPGVEGSGGMSGPGLLTGPLPVQRSWRWTWRAWCSEVRLSCCGASAQARSTATHTVAVPGYDPHRPERPLPSAHSVPSGQSPHRASRAAWSHCWNGLKGPWCGSRCSLYPAAGSWQSHLGEGCWAPRALQGRQLGPRPPSQACL", "length": 314, "header": "tr|E1BBZ1-1|E1BBZ1_BOVIN Isoform 1 of Max dimerization protein 3 OS=Bos taurus OX=9913 GN=MXD3 PE=4 SV=2 CANONICAL=E1BBZ1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TX61-1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ1/entry#A0AAA9TX61-1", "sequence": { "sequence": "MGEGVSRPRLRGAHVQRQSPGPRVDHPPPEHHSACGLLVTSTGLETEAQKHQMIGAGSLSEAARRGTPTPARAFARGPGLKPTLARPPPAVADMEPVASNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPVHRRRKRSPQAPGALDSGRSVHNELEKRRRAQLKRCLEQLKQQMPLGADCVRYTTLSLLRRARMHIQKLEEQEQRARQLKEKLRSKQQSLRRQLEQLRGLGTVGERERLRADSLDSSGLSSERSDSDQEELEVDVESLVFGGEAELLRGFSAGQEHSYSHSGSAWL", "length": 299, "header": "tr|A0AAA9TX61-1|E1BBZ1_BOVIN Computationally mapped isoform of Max dimerization protein 3 OS=Bos taurus OX=9913 GN=MXD3 PE=4 SV=1 CANONICAL=E1BBZ1-1" }, "locus": { "chromosome": "7", "start_pos": 38784477, "end_pos": 38780095, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100621.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100621.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102939.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102939.1" } ] } }, { "isoform_ac": "E1BBZ1-1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ1/entry#E1BBZ1-1", "sequence": { "sequence": "MEPVASNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPVHRRRKRSPQAPGALDSGRSVHNELEKRRRAQLKRCLEQLKQQMPLGADCVRYTTLSLLRRARMHIQKLEEQEQRARQLKEKLRSKQQSLRRQLEQLRGLGTVGERERLRADSLDSSGLSSERSDSDQGKCPGVEGSGGMSGPGLLTGPLPVQRSWRWTWRAWCSEVRLSCCGASAQARSTATHTVAVPGYDPHRPERPLPSAHSVPSGQSPHRASRAAWSHCWNGLKGPWCGSRCSLYPAAGSWQSHLGEGCWAPRALQGRQLGPRPPSQACL", "length": 314, "header": "tr|E1BBZ1-1|E1BBZ1_BOVIN Isoform 1 of Max dimerization protein 3 OS=Bos taurus OX=9913 GN=MXD3 PE=4 SV=2 CANONICAL=E1BBZ1-1" }, "locus": { "chromosome": "7", "start_pos": 38783990, "end_pos": 38779845, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006596.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006596.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006596.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006596.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ1" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ1" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ1" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ1" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BBZ1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BBZ1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 314, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BBZ1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BBZ1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BBZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBZ1" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 57, "end_pos": 109, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B8G8-1", "uniprot_ac": "E1B8G8", "uniprot_id": "E1B8G8_BOVIN", "mass": { "chemical_mass": 153155.0, "monoisotopic_mass": 153155.0 }, "refseq": { "ac": "XP_024846118", "name": "sushi, nidogen and EGF-like domain-containing protein 1 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846118" }, "gene_names": [ { "name": "SNED1", "type": "recommended", "evidence": [ { "id": "E1B8G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8G8" } ] }, { "name": "SNED1", "type": "synonym", "evidence": [ { "id": "XP_024846118", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846118" } ] } ], "protein_names": [ { "name": "Sushi, nidogen and EGF-like domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "E1B8G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8G8/entry#names_and_taxonomy" } ] }, { "name": "sushi, nidogen and EGF-like domain-containing protein 1 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_024846118", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846118" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B8G8", "url": "https://www.uniprot.org/uniprotkb/E1B8G8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNED1", "url": "https://www.uniprot.org/uniprotkb/E1B8G8", "locus": { "chromosome": "3", "start_pos": 120324147, "end_pos": 120254325, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014132", "url": "https://www.ensembl.org/id/ENSBTAG00000014132" } ] } } ], "crossref": [ { "id": "ENSBTAG00000014132", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014132", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00033", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00033", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514207", "url": "https://www.ncbi.nlm.nih.gov/gene/514207", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003886", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003886", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013032", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013032", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035976", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035976", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B8G8", "url": "https://www.orthodb.org/?gene=E1B8G8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12916", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12916", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12916:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12916:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00008", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00008", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06119", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06119", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12661", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12661", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024846118", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846118", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TXK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8G8", "url": "https://www.uniprot.org/uniprotkb/E1B8G8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8G8-1", "url": "https://www.uniprot.org/uniprotkb/E1B8G8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRGATWALLLAAALGLGARGARGAVALADFYPFGTERGDAVTPKQDDGGSGLRPLSVLFPFFGAEHSGLYVNNNGIISFLKEVSQFTPVAFPIAKDRCVVAAFWADVDNRRAGDVYFREATDAATLRRATADVRRYFPELPGFSATWVFVATWYRVTFFGGSASSPVNTFQTVLITDGTLSFTIFNYESITWTTGTHASSGGNASGLGGIAAQAGFNAGDGQRYFSIPGSRTADMAEVETTTNVGVPGRWAFRIDDAQVRVGGCGHTTSVCQTLRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRTCHLDVNECASHPCQNGGTCTHGVNSFSCQCPAGFRGPTCETAESPCDDRECQNGGWCRAEGGAAACVCPAGYTGAACETDVDECSSDPCLNGGSCVDLVGNFTCLCAEPFEGPRCETGHHPVSDACLSGPCQNGGTCVDADQGYVCECPEGFMGLDCRERTPSSCECRNGGRCLGANSSLCQCPPGFFGLLCEFEVTATPCNMNTQCPDGGYCMEYGGSYLCVCHADHNVSHSLPSPCDSDPCFNGGSCDAHEDSYTCECPRGFHGRHCEKARPRLCSSGPCRNGGTCKEAGGEYHCDCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCMNGGTCEDLGTDFSCHCQAGYTGRRCQAEVDCGPPGEVQHATLRFNGTRLGSVALYLCDRGYSPSASSHVRVCQPQGVWSEPPQCHEIDECRSQPCLHGGSCQDRIAGYLCVCSPGREGTHCERETDKCQAQPCRNGGTCRDLPGASVCQCPPGFTGVHCETEVDACDSSPCQHGGRCENGGGAYLCVCPEGFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGRDCDKELFPPTALKVEQVEESGVSISWRPPEGPAARQLLDGYAVTYVSSDGSYRRTDFVDRGRSAHQLRALAPGRAYNVSVFSVKRNANNKNDISRPVVLLARTRPRPIEGLEVANVTASAISVRWALHRIRHATVSSVRLSIRHPEAQEEQSTDVDRSVDRFTFRALLPGRRYAIWVTALSGLGGQERPTESLASAPVHVWTRPLPPANLTAARVTATSAHVVWDAPAPGASLEAYVINVTTSQSTKSRYVPNGRLVSYTVRDLAPGRRYQLSVTAVQSTGGGQLHSEPAHLYIITSLRDSTNGRWHRDGLPQRALRTRPAPARLPELRLLNDPGAPAMPTQVPRFSELVDGRGRVRARFSGSPSKRVTVRSQPTALVQLENTDAVPTPASLALQLPERGGDKDVESKSAGAEYRADHPQGPEDDAPGNCSENPCQNGGTCVPGEDAHSCDCSPGFKGRHCELACTKVPQPCTRLFSETKSMPVWEGGVCRHVYKRVYKVHPDTCFKESCESTRTRAPDRKQSNSPTLKKS", "length": 1431, "header": "tr|E1B8G8-1|E1B8G8_BOVIN Isoform 1 of Sushi, nidogen and EGF-like domain-containing protein 1 OS=Bos taurus OX=9913 GN=SNED1 PE=4 SV=4 CANONICAL=E1B8G8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TXK5-1", "url": "https://www.uniprot.org/uniprotkb/E1B8G8/entry#A0AAA9TXK5-1", "sequence": { "sequence": "MLRGATWALLLAAALGLGARGARGAVALADFYPFGTERGDAVTPKQDDGGSGLRPLSVLFPFFGAEHSGLYVNNNGIISFLKEVSQFTPVAFPIAKDRCVVAAFWADVDNRRAGDVYFREATDAATLRRATADVRRYFPELPGFSATWVFVATWYRVTFFGGSASSPVNTFQTVLITDGTLSFTIFNYESITWTTGTHASSGGNASGLGGIAAQAGFNAGDGQRYFSIPGSRTADMAEVETTTNVGVPGRWAFRIDDAQVRVGGCGHTTSVCQTLRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRTCHLDVNECASHPCQNGGTCTHGVNSFSCQCPAGFRGPTCETAESPCDDRECQNGGWCRAEGGAAACVCPAGYTGAACETDVDECSSDPCLNGGSCVDLVGNFTCLCAEPFEGPRCETGHHPVSDACLSGPCQNGGTCVDADQGYVCECPEGFMGLDCRERTPSSCECRNGGRCLGANSSLCQCPPGFFGLLCEFEVTATPCNMNTQCPDGGYCMEYGGSYLCVCHADHNVSHSLPSPCDSDPCFNGGSCDAHEDSYTCECPRGFHGRHCEKARPRLCSSGPCRNGGTCKEAGGEYHCDCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCMNGGTCEDLGTDFSCHCQAGYTGRRCQAEVDCGPPGEVQHATLRFNGTRLGSVALYLCDRGYSPSASSHVRVCQPQGVWSEPPQCHEIDECRSQPCLHGGSCQDRIAGYLCVCSPGREGTHCERETDKCQAQPCRNGGTCRDLPGASVCQCPPGFTGVHCETEVDACDSSPCQHGGRCENGGGAYLCVCPEGFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGRDCDKELFPPTALKVEQVEESGVSISWRPPEGPAARQLLDGYAVTYVSSDGSYRRTDFVDRGRSAHQLRALAPGRAYNVSVFSVKRNANNKNDISRPVVLLARTRPRPIEGLEVANVTASAISVRWALHRIRHATVSSVRLSIRHPEAQEEQSTDVDRSVDRFTFRALLPGRRYAIWVTALSGLGGQERPTESLASAPVHVWTRPLPPANLTAARVTATSAHVVWDAPAPGASLEAYVINVTTSQSTKSRYVPNGRLVSYTVRDLAPGRRYQLSVTAVQSTGGGQLHSEPAHLYIITSLRDSTNGRWHRDGLPQRALRTRPAPARLPELRLLNDPGAPAMPTQVPRFSELVDGRGRVRARFSGSPSKRVTVRSHAPGNCSENPCQNGGTCVPGEDAHSCDCSPGFKGRHCELACTKVPQPCTRLFSETKSMPVWEGGVCRHVKQSNSPTLKKS", "length": 1352, "header": "tr|A0AAA9TXK5-1|E1B8G8_BOVIN Computationally mapped isoform of Sushi, nidogen and EGF-like domain-containing protein 1 OS=Bos taurus OX=9913 GN=SNED1 PE=4 SV=1 CANONICAL=E1B8G8-1" }, "locus": { "chromosome": "3", "start_pos": 120324143, "end_pos": 120254524, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102738.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102738.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101381.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101381.1" } ] } }, { "isoform_ac": "E1B8G8-1", "url": "https://www.uniprot.org/uniprotkb/E1B8G8/entry#E1B8G8-1", "sequence": { "sequence": "MLRGATWALLLAAALGLGARGARGAVALADFYPFGTERGDAVTPKQDDGGSGLRPLSVLFPFFGAEHSGLYVNNNGIISFLKEVSQFTPVAFPIAKDRCVVAAFWADVDNRRAGDVYFREATDAATLRRATADVRRYFPELPGFSATWVFVATWYRVTFFGGSASSPVNTFQTVLITDGTLSFTIFNYESITWTTGTHASSGGNASGLGGIAAQAGFNAGDGQRYFSIPGSRTADMAEVETTTNVGVPGRWAFRIDDAQVRVGGCGHTTSVCQTLRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRTCHLDVNECASHPCQNGGTCTHGVNSFSCQCPAGFRGPTCETAESPCDDRECQNGGWCRAEGGAAACVCPAGYTGAACETDVDECSSDPCLNGGSCVDLVGNFTCLCAEPFEGPRCETGHHPVSDACLSGPCQNGGTCVDADQGYVCECPEGFMGLDCRERTPSSCECRNGGRCLGANSSLCQCPPGFFGLLCEFEVTATPCNMNTQCPDGGYCMEYGGSYLCVCHADHNVSHSLPSPCDSDPCFNGGSCDAHEDSYTCECPRGFHGRHCEKARPRLCSSGPCRNGGTCKEAGGEYHCDCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCMNGGTCEDLGTDFSCHCQAGYTGRRCQAEVDCGPPGEVQHATLRFNGTRLGSVALYLCDRGYSPSASSHVRVCQPQGVWSEPPQCHEIDECRSQPCLHGGSCQDRIAGYLCVCSPGREGTHCERETDKCQAQPCRNGGTCRDLPGASVCQCPPGFTGVHCETEVDACDSSPCQHGGRCENGGGAYLCVCPEGFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGRDCDKELFPPTALKVEQVEESGVSISWRPPEGPAARQLLDGYAVTYVSSDGSYRRTDFVDRGRSAHQLRALAPGRAYNVSVFSVKRNANNKNDISRPVVLLARTRPRPIEGLEVANVTASAISVRWALHRIRHATVSSVRLSIRHPEAQEEQSTDVDRSVDRFTFRALLPGRRYAIWVTALSGLGGQERPTESLASAPVHVWTRPLPPANLTAARVTATSAHVVWDAPAPGASLEAYVINVTTSQSTKSRYVPNGRLVSYTVRDLAPGRRYQLSVTAVQSTGGGQLHSEPAHLYIITSLRDSTNGRWHRDGLPQRALRTRPAPARLPELRLLNDPGAPAMPTQVPRFSELVDGRGRVRARFSGSPSKRVTVRSQPTALVQLENTDAVPTPASLALQLPERGGDKDVESKSAGAEYRADHPQGPEDDAPGNCSENPCQNGGTCVPGEDAHSCDCSPGFKGRHCELACTKVPQPCTRLFSETKSMPVWEGGVCRHVYKRVYKVHPDTCFKESCESTRTRAPDRKQSNSPTLKKS", "length": 1431, "header": "tr|E1B8G8-1|E1B8G8_BOVIN Isoform 1 of Sushi, nidogen and EGF-like domain-containing protein 1 OS=Bos taurus OX=9913 GN=SNED1 PE=4 SV=4 CANONICAL=E1B8G8-1" }, "locus": { "chromosome": "3", "start_pos": 120324143, "end_pos": 120254524, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018790.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018790.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018790.7", "url": "https://www.ensembl.org/id/ENSBTAP00000018790.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1288, "start_aa": "Thr", "end_pos": 1288, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1288", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "E1B8G8", "url": "https://www.uniprot.org/uniprotkb/E1B8G8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "E1B8G8", "url": "https://www.uniprot.org/uniprotkb/E1B8G8" } ], "pmid": "" }, { "name": "Notch binding", "id": "GO:0005112", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005112", "evidence": [ { "database": "UniProtKB", "id": "E1B8G8", "url": "https://www.uniprot.org/uniprotkb/E1B8G8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell-matrix adhesion", "id": "GO:0007160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "database": "UniProtKB", "id": "E1B8G8", "url": "https://www.uniprot.org/uniprotkb/E1B8G8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1015, "end_pos": 1017, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1109, "end_pos": 1111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1139, "end_pos": 1141, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1329, "end_pos": 1331, "annotation": "n_glycosylation_sequon" }, { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 408, "end_pos": 410, "annotation": "n_glycosylation_sequon" }, { "start_pos": 484, "end_pos": 486, "annotation": "n_glycosylation_sequon" }, { "start_pos": 536, "end_pos": 538, "annotation": "n_glycosylation_sequon" }, { "start_pos": 712, "end_pos": 714, "annotation": "n_glycosylation_sequon" }, { "start_pos": 886, "end_pos": 888, "annotation": "n_glycosylation_sequon" }, { "start_pos": 977, "end_pos": 979, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B8G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8G8" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 268, "end_pos": 309, "start_aa": "Thr", "end_aa": "His", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B8G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8G8" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 908, "end_pos": 1006, "start_aa": "Pro", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B8G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8G8" }, { "id": "PS51220", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51220" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NIDO", "eco_id": "ECO_0000259", "start_pos": 103, "end_pos": 258, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B8G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8G8" }, { "id": "PS50923", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50923" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sushi", "eco_id": "ECO_0000259", "start_pos": 696, "end_pos": 753, "start_aa": "Val", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1288 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1015, "end_pos": 1017 }, { "start_pos": 1109, "end_pos": 1111 }, { "start_pos": 1139, "end_pos": 1141 }, { "start_pos": 1329, "end_pos": 1331 }, { "start_pos": 204, "end_pos": 206 }, { "start_pos": 408, "end_pos": 410 }, { "start_pos": 484, "end_pos": 486 }, { "start_pos": 536, "end_pos": 538 }, { "start_pos": 712, "end_pos": 714 }, { "start_pos": 886, "end_pos": 888 }, { "start_pos": 977, "end_pos": 979 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B7F5-1", "uniprot_ac": "E1B7F5", "uniprot_id": "E1B7F5_BOVIN", "mass": { "chemical_mass": 125290.0, "monoisotopic_mass": 125290.0 }, "refseq": { "ac": "NP_001179695", "name": "WD repeat and HMG-box DNA-binding protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179695" }, "gene_names": [ { "name": "WDHD1", "type": "recommended", "evidence": [ { "id": "E1B7F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7F5" } ] }, { "name": "WDHD1", "type": "synonym", "evidence": [ { "id": "NP_001179695", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179695" } ] } ], "protein_names": [ { "name": "WD repeat and HMG-box DNA-binding protein 1", "type": "recommended", "evidence": [ { "id": "E1B7F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7F5/entry#names_and_taxonomy" } ] }, { "name": "Acidic nucleoplasmic DNA-binding protein 1", "type": "synonym", "evidence": [ { "id": "E1B7F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7F5/entry#names_and_taxonomy" } ] }, { "name": "WD repeat and HMG-box DNA-binding protein 1", "type": "synonym", "evidence": [ { "id": "NP_001179695", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179695" } ] } ], "function": [ { "annotation": "Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork.", "evidence": [ { "database": "UniProtKB", "id": "E1B7F5", "url": "https://www.uniprot.org/uniprotkb/E1B7F5#function" }, { "database": "UniProtKB", "id": "ARBA00056293", "url": "https://www.uniprot.org/uniprotkb/ARBA00056293#function" }, { "database": "UniProtKB", "id": "A0AAA9TY65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY65#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7F5", "url": "https://www.uniprot.org/uniprotkb/E1B7F5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDHD1", "url": "https://www.uniprot.org/uniprotkb/E1B7F5", "locus": { "chromosome": "10", "start_pos": 67450966, "end_pos": 67504493, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019120", "url": "https://www.ensembl.org/id/ENSBTAG00000019120" } ] } } ], "crossref": [ { "id": "E1B7F5", "url": "https://alphafold.ebi.ac.uk/entry/E1B7F5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019120", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019120", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21993", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21993", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540681", "url": "https://www.ncbi.nlm.nih.gov/gene/540681", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022100", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022100", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055339", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055339", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057646", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057646", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540681", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540681", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RYAHTNG", "url": "https://omabrowser.org/oma/group/RYAHTNG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7F5", "url": "https://www.orthodb.org/?gene=E1B7F5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19932", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19932", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19932:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19932:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12341", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12341", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20946", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20946", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24815", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24815", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24817", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24817", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179695", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TY65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7F5", "url": "https://www.uniprot.org/uniprotkb/E1B7F5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7F5-1", "url": "https://www.uniprot.org/uniprotkb/E1B7F5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPATQKPMRYGHTEGHTDVCFDDSGSCIVTCGSDGDVRIWEDLDDDDPKSINVGEKAYSCALKNGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDCSQQKTFRGHDAPVLSLSFDPKDIFLASSSCDGSVKVWQISDQTCPISWPLLQKCNDVVNAKSICRLAWQPKSGKLLAVPVEKSVKLYKRETWSNQFDLSDDVISQTLNIVTWSPCGQYLAAGSINGLIIIWNVETKNCIERVKHEKGYAICGLSWHPTCGQIAYTDAEGNLGLLENVCDPSGKMSNRKVSSRVEKDYNDLFDGDDTSNVGDCLNDSAVKTHSFSKGIVNDEEDDDDLMLASGRPRQRSHILEDDENSVDVTMLKIGSSLFKEEEDDQGGSIHNLPVVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATHLLNTFNYTVADLSHEAVLLACESTDELASKLHCLHLSSWDSSKEWIVDMPPNEDIEAICLGQGWAAAATSSLLLRLFTIGGVQKEVFSLPGPIVSMAGHGEQLVIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGDPLPLTRKSYLVWVGFSAEGTPCYVDSEGIVRMLNRGLGHTWTPVCNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAVLSFKLPYCQTATEKGQMEEQYWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLLKMLALSCKLEREFRCVELAGLMTQNAVNLAIKYASRSRRLILAQRLGELAVEKAAELAATQAEEEEEEDFRKKLNVGYSNTSTEWSQPRLRNQVEEDTEDNGEADNTEENTEIHKHGQNPFFKSADSSDMPALKSGAVTSSSQGRINPFKVSGNSKEPAISVSSGRSTNILDTMNKSSKKSTALNRATDNEKSPVIKPLIPKPKPKQASAASFFQKRTSQADRTEEVKEENPKNSSSETPAVCPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEGMVRFKVLSSEERKAWAARAKGGTASDGAEEKKRKRVVDESQETENQEEKMKNLNLPKKQKPLDLSTNQKLSAFAFKQE", "length": 1127, "header": "tr|E1B7F5-1|E1B7F5_BOVIN Isoform 1 of WD repeat and HMG-box DNA-binding protein 1 OS=Bos taurus OX=9913 GN=WDHD1 PE=4 SV=2 CANONICAL=E1B7F5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TY65-1", "url": "https://www.uniprot.org/uniprotkb/E1B7F5/entry#A0AAA9TY65-1", "sequence": { "sequence": "MPATQKPMRYGHTEGHTDVCFDDSGSCIVTCGSDGDVRIWEDLDDDDPKSINVGEKAYSCALKNGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDCSQQKTFRGHDAPVLSLSFDPKDIFLASSSCDGSVKVWQISDQTCPISWPLLQKCNDVVNAKSICRLAWQPKSGKLLAVPVEKSVKLYKRETWSNQFDLSDDVISQTLNIVTWSPCGQYLAAGSINGLIIIWNVETKNCIERVKHEKGYAICGLSWHPTCGQIAYTDAEGNLGLLENVCDPSGKMSNRKVSSRVEKDYNDLFDGDDTSNVGDCLNDSAVKTHSFSKGIVNDEEDDDDLMLASGRPRQRSHILEDDENSVDVTMLKIGSSLFKEEEDDQGGSIHNLPVVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATHLLNTFNYTVADLSHEAVLLACESTDELASKLHCLHLSSWDSSKEWIVDMPPNEDIEAICLGQGWAAAATSSLLLRLFTIGGVQKEVFSLPGPIVSMAGHGEQLVIVYHRGTPCYVDSEGIVRMLNRGLGHTWTPVCNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAVLSFKLPYCQTATEKGQMEEQYWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLLKMLALSCKLEREFRCVELAGLMTQNAVNLAIKYASRSRRLILAQRLGELAVEKAAELAATQAEEEEEEDFRKKLNVGYSNTSTEWSQPRLRNQVEEDTEDNGEADNTEENTEIHKHGQNPFFKSADSSDMPALKSGAVTSSSQGRINPFKVSGNSKEPAISVSSGRSTNILDTMNKSSKKSTALNRATDNEKSPVIKPLIPKPKPKQASAASFFQKRTSQADRTEEVKEENPKNSSSETPAVCPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEGMVRFKVLSSEERKAWAARAKGGTASDGAEEKKRKRVVDESQETENQEEKMKNLNLPKKQKPLDLSTNQKLSAFAFKQE", "length": 1081, "header": "tr|A0AAA9TY65-1|E1B7F5_BOVIN Computationally mapped isoform of WD repeat and HMG-box DNA-binding protein 1 OS=Bos taurus OX=9913 GN=WDHD1 PE=4 SV=1 CANONICAL=E1B7F5-1" }, "locus": { "chromosome": "10", "start_pos": 67504166, "end_pos": 67451578, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105110.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105110.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102146.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102146.1" } ] } }, { "isoform_ac": "E1B7F5-1", "url": "https://www.uniprot.org/uniprotkb/E1B7F5/entry#E1B7F5-1", "sequence": { "sequence": "MPATQKPMRYGHTEGHTDVCFDDSGSCIVTCGSDGDVRIWEDLDDDDPKSINVGEKAYSCALKNGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDCSQQKTFRGHDAPVLSLSFDPKDIFLASSSCDGSVKVWQISDQTCPISWPLLQKCNDVVNAKSICRLAWQPKSGKLLAVPVEKSVKLYKRETWSNQFDLSDDVISQTLNIVTWSPCGQYLAAGSINGLIIIWNVETKNCIERVKHEKGYAICGLSWHPTCGQIAYTDAEGNLGLLENVCDPSGKMSNRKVSSRVEKDYNDLFDGDDTSNVGDCLNDSAVKTHSFSKGIVNDEEDDDDLMLASGRPRQRSHILEDDENSVDVTMLKIGSSLFKEEEDDQGGSIHNLPVVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATHLLNTFNYTVADLSHEAVLLACESTDELASKLHCLHLSSWDSSKEWIVDMPPNEDIEAICLGQGWAAAATSSLLLRLFTIGGVQKEVFSLPGPIVSMAGHGEQLVIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGDPLPLTRKSYLVWVGFSAEGTPCYVDSEGIVRMLNRGLGHTWTPVCNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAVLSFKLPYCQTATEKGQMEEQYWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLLKMLALSCKLEREFRCVELAGLMTQNAVNLAIKYASRSRRLILAQRLGELAVEKAAELAATQAEEEEEEDFRKKLNVGYSNTSTEWSQPRLRNQVEEDTEDNGEADNTEENTEIHKHGQNPFFKSADSSDMPALKSGAVTSSSQGRINPFKVSGNSKEPAISVSSGRSTNILDTMNKSSKKSTALNRATDNEKSPVIKPLIPKPKPKQASAASFFQKRTSQADRTEEVKEENPKNSSSETPAVCPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEGMVRFKVLSSEERKAWAARAKGGTASDGAEEKKRKRVVDESQETENQEEKMKNLNLPKKQKPLDLSTNQKLSAFAFKQE", "length": 1127, "header": "tr|E1B7F5-1|E1B7F5_BOVIN Isoform 1 of WD repeat and HMG-box DNA-binding protein 1 OS=Bos taurus OX=9913 GN=WDHD1 PE=4 SV=2 CANONICAL=E1B7F5-1" }, "locus": { "chromosome": "10", "start_pos": 67504166, "end_pos": 67451578, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025453.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025453.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025453.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025453.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 426, "start_aa": "Thr", "end_pos": 426, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr426", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:540681", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540681", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PDL4-1", "protein_name": "WD repeat and HMG-box DNA-binding protein 1", "gene_name": "WDHD1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPSEQKPMRYGHTEGHTDVCFDDSGSCIVTCGSDGDVRIWENLDDDDPKSINVGEKAYSCALKNGKLITAVSNNTVQIHTFPEGAPDGILTRFTMNANHVVFNSDGAKIAAGSSDFMVKVVEVADSSKQKTFRGHDAPVLSLSFDPMDIYLASASCDGSVRVWKVEDQTCVTNWLLLQKCNDVINAKSICRLAWQPGSGKLLAIPVDKVVKLYRRETWDNQVDLSDTSITQPLNVVVWSPCGQYLAAGSVNGSIVVWKVETRECTERMKHEKSYSICGLAWHPRYEQIAYTDTEGNLGLWEDIGDGKKPNDKVASTVTKDYEDLFDGDDDDYLNGDMIEPPSSPNTGANEDHGDDDDLMPTSGHPRRAIIDDDDNSLDIGMIKANSNLLEKEEDDDDQIGGFPALPTSSTQQPFYDGPRPTPRQKPFQSGSTPVHLMHRFMVWNSVGIIRCYNDEQDNAIDIEFHDTSIHHATHLPNSLNHTMADLSTEAILLACESTEELASKLHCIYFSSWDANKEWTVDMPKDEDIEAICLGQGWAACATSALLVRLFTVGGVQKEIFCLPGPVVSMAGHGEQLMVIYHRGTGFDGDQCLGVQLMELGKKKKQILHGDPLSLTKKSYLVWVGFSAEGTPCYVDSEGIVRMLNRGLGNTWIPVCNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGARFPPTLPRPAVAILPFTLPYCQVTTEKGQMEEQYWRSVVFHNYVDYLSKNGYELDENAKSQPVKEQQELLMKLFALSCKLEREFRCVELADLMTQNVVNLAIKYASRSRRLNLAQRLSEMAVEKASELATALEDEEEEEEEDFRTHLNAGYSTSATEWGRLPGRSAQQDQEMEEAEETNGYEEAEGTPEVPKQRPNPFSKAVSSAEVITPKSAVIASSSQGRVNPFKVSSNKKDPLVPSSNVLDTMSKYSKKISSSRAVNKQSSPVIKPLIPKPKSKQASAASFFQVRTPGSSEKRVGEREEKAGHEPPEVQVTAQDNTENKRPKTGFQMWLEENRANILTDNPDLNEAEVIKEGMSRFRILSSEERMVWTEKAKGGAVTDLTEDKKRKRPTAAEDEAKKNEEQKSEDSNVSKKKKPLDQATNVRLSSFAFKQS", "length": 1123 }, "evidence": [ { "id": "E1B7F5", "url": "https://omabrowser.org/oma/group/E1B7F5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZN63-1", "protein_name": "WD repeat and HMG-box DNA-binding protein 1", "gene_name": "Wdhd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPAIQKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRMWEDLDDDDPKSVNVGEKAFSCALKNGKLVTAVSNNTVQVYTFPEGAPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKVVDVMDNSQQQTFRGHDAPVLSLSFDPKDVFLASASCDGTVRVWNISDQTCAASWPVLRKSNDVVNSESICRLAWQPKTGKFLAVPVEKSVKLYRRETWSNPFDLSDSSVTQTLNIVTWSPCGQYLAAGAINGLIVVWNVETKECMERVKHEKGYAICGLAWHPTYSRICYTDVEGNLGILENVCDLSGKLSSNKVPSGVEKDYSDLFDGDDTSSAGDFLNDNAVEIPSFSKGIRNEEDDNDDLMLAADHVLGDDENSVDVTMLRNDLHREEGEDRQASSLHSLPLVKSQRPLYDGPMPTPRQKPFQPSSTPLHLTHRFMAWNSVGIIRCYNDDQDSAIDVEFHDTSIHHATHLSNAFNYTMGSLSHEAVLLACESADELASKLHCLHFSSWDSSKEWIVDMPENEDIEAICLGLGWAAAATSALLLRLFTIGGVQKEVFCLPGPVVSMAGHGEQLCIVYHRGTGFDGDQCLGVQLLELGRKKKQVLHGDPLPLTRKSYLTWLGFSAEGTPCYVDSEGCVRMLNRGLGNTWTPVCNIREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILPFKLPYCQTSTEKGQMEEQFWHSVLFHNYLDYLAENGYDYEESIKKQAVKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVHLAIKYASRSRKLILAQKLSELAAEKAAELAEIQTEEREEDFRERLNAGYSHTTTEWSQPRVRSQVEEDAEDREDTVSEGNPEPQNHVIGQNLIQSANSSDTPAMKSGAVFSSSQGRVNPFKVLVSSKEPAVSVNATRSANILDNMNKLSRKSTSFNRVANNEKSPVIKPLIPKPRCKQASAASYFQKRTSQAEKTEEVKENPKSSSSEAPAVCLQNSEVQRPKTGFQMWLEENRSHIMSDNPDISDEADIIKEGMIRFRVLSAEERKEWTNKAKGGTASDGAEAKKRKRGVSEICETEKQEEAVKENLELSKKQKALDLSTNQKLSAFAFKQE", "length": 1119 }, "evidence": [ { "id": "E1B7F5", "url": "https://omabrowser.org/oma/group/E1B7F5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SSP1-1", "protein_name": "WD repeat and HMG-box DNA-binding protein 1", "gene_name": "WDHD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPATQKPMRYGHTEGHTDVCFDDSGSCIVTCGSDGDVRIWEDLDDDDPKSINVGEKAYSCALKNGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVIFNEDGTKIAAGSSDFLVKVVDVMDCSQQKTFRGHDAPVLSLSFDPKDIFLASSSCDGSVKVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAVPVEKSVKLYRRETWSNQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLSWHPTCGQIAYTDAEGNLGLLENVCDPNGKMSGSKVSSRVERDYNDLFDGDDTGNVGDFPNDNAVETHSFSKETRNDEEDDDDLMLASGRPRQRSHILEDDENSVDVTMLKTGSSRLKEEEEDDQAGNIHSLPLITSQKPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATHLSNTLNYTVADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIVDMPPNEDIEAVCLGQGWAAAATSSLLLRLFTIGGVQKEVFSLPGPVVSMAGHGEQLIIVYHRGTGFDGDQCLGIQLLQLGKKKKQILHGDPLPLTRKSYLVWLGFSAEGTPCYVDSEGIVRMLNRGLGYTWTPICNTREHCKGKSDHYWVVGIHENPQHLRCIPCKGSRFPPTLPRPAIAVLSFKLPYCQTGTEKGQMEEQYWRSVLFHNHLDYLAKSGYEYEESTKNQAIKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVNLAIKYASRSRRLILAQKLSELAVEKAAELAAPQAEEEEEEEEDFRKKLNAGYSNTPTEWSQPRLRNRVEEDTEDTEEVDDIEEKPEIHKHRQNPFFKSADSTDVPAIKSGAVTSSSQGRINPFKVSGSSKEPANSFSSVRSTNILDNMNKSKKSALNRATNNEKSPVIKPLVPKPKSKQASAASFFQKRTSQTDKTEEIKEENTKNSSSETPAVCPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEGMVRFRVLSAEERKAWAAKAKGGIASDGAEEKKRKRVVDESHETENQEEKTKENLNLPKKQKPLNLSANQKLSAFAFKQE", "length": 1129 }, "evidence": [ { "id": "E1B7F5", "url": "https://omabrowser.org/oma/group/E1B7F5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F4JF14-1", "protein_name": "Protein ENHANCER OF LHP1 1", "gene_name": "EOL1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MKSRSLKLREAHKVGGSAAFCSILWDHKAEHFVTSSSSDPSISVHDGLSTSTLPPTILRHHQDGVTSLALSNDSTLLASGSIDHCVKLYKFPSGEFQTNITRFTLPIRVLAFNGSGSLLAAAGDDEGIKLINTFDGSIVRVLKGHKGPVTGLDFHPNGELLASIDTTGTVLCWELQNGVVSFTLKGVAPDTGFNTSIVNIPRWSPDGRTLAVPGLRNDVVMYDRFTGEKLFALRGDHLEAICYLTWAPNGKYIATSGLDKQVLLWDVDKKQDIDRHKFEERICCMSWKPNGNALSVIDAKGRYGVWESLVPSSMLSPTVGVPDIVPKKRNEILDFDDEVEEEIYRASESLDDAMGDSDDGESHHTSRKRLRKKTLIDEDVDDAYEELNDGSSLPSASEYRKKSHRGHREKQGARSGAFKGISASTKYKMQSSFQPGATPPEPGKRTFLCYNMLGCITTIEHEGNSRIETDFHDTGRGPRVSSMIDIYGFTMASINETGCVFANPCKGEKNMSVLMYRPFRSWASNSEWTMRFEGEEVKVVANGSGWVAAVTSLNLLRVFSEGGLQKHILSLDGPVVTAVGCKDHLAVVTHVSDCLPSNEQVMEFRVFNISKMTQELKGRVALTPGSRLTWIGFSEEGSLSSYDSEGVLRVFTSQYGGSWIPVFSTSKEKKQEENYWVVGLNTSSLYCIACKYAEMFPQVTPKPILTILDLSLPLASSDLGAASLENELILKQLRLYETQRKVDDMALVGVDTTALEDEAFDLEVSQDKCILRLISSCCSSDSFARASELMELLTLEKSMRAAITLVTKLKLPFLAEKFSSILEERLLEEASEAAVTNPALNPNGEVVTRVESKVQNPPASIQTSENTEAVMKSSATKLSAPTLLKKSKVSEGLKLGKEQTKKDKSDDAKIKEIKKLNLKNPVNNVNKEDKGQEKEVNQGEARRSSNPFLKSTV", "length": 953 }, "evidence": [ { "id": "E1B7F5", "url": "https://omabrowser.org/oma/group/E1B7F5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "O75717-1", "protein_name": "WD repeat and HMG-box DNA-binding protein 1", "gene_name": "WDHD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLLENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDDEDLMMASGRPRQRSHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATHLSNTLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICLGQGWAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTPICNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIATEKGQMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKKLNAGYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKSGAVTFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPIIKPLIPKPKPKQASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEAKKRKRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE", "length": 1129 }, "evidence": [ { "id": "E1B7F5", "url": "https://omabrowser.org/oma/group/E1B7F5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P59328-1", "protein_name": "WD repeat and HMG-box DNA-binding protein 1", "gene_name": "Wdhd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPATQKPMRYGHTEGHTEVCFDDSGSYIVTCGSDGDVRMWEDLDDDDPKSVNVGEKAFSCALKNGKLVTAVSNNTVQVYTFPEGVPDGILTRFTTNANHVVFNGAGNKIAAGSSDFLVKVVDVMDNSQQQTFRGHDAPVLSLSFDPKDIFLASASCDGTVRVWNISDQTCAVSWPVLQKSNDVVNAKSICRLAWQPKAGKLLAVPVEKSVKLYRRETWSNPFDLSDSSISQTLNIVTWSPCGQYLAAGAINGLIVVWNVETKDCMERVKHEKGYAICGLAWHPTCSRICYTDVEGNLGVLENVCDLSGKVSSNKVSSRVEKDYNDLFDGDDTSSAGDFLNDNAVEIPSFSKGIINEDDDNDDIMLAADHDLGDDENSVDVTMLKADLSHKEEGDDDQARSIHNLPLIRPQRPFYDGPMPTPRQKPFQSSSTPLHLSHRFMVWNSVGIIRCYNDDQDSAIDVEFHDTSIHHATHLLNAFNYTMGTLSHEAILLACESADELASKLHCLHFSSWDSSKEWMVDMPQNEDIEAICLGLGWAAAATTALLLRLFTIGGVQKEVFCLPGPVVSMAGHGEQLCIVYHRGTGFDGDQCLGVQLLELGRKKNQVLHGDPLPLTRKSYLTWLGFSAEGTPCYVDSEGCVRMLNRGLGNTWTPVCNIREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQTSTEKGQMEEQFWHSVLFHNYLDYLAKNGYDYEESIKNQAVKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVHLAIKYASRSRKLILAQKLSELAAEKAAELAETQSEEEKEEDFREKLNAGYSHTTTEWSRPRVRSQVEDAEDREDTVSEEKPESHNHGQNLFQSANSSDTPALKSGAVFSSSQGWVNPFKVVVSSKEPAVSANSTRSANILDSMNKSSRKSTSLNRMENNEKSPVIKPLTPKPRSKQASAASYFQKRTPQADKTEEVKENPKSSSSDAPAVCLQNSENQRPKTGFQMWLEENRSQILSDNPDISDETDIIKEGMIRFRVLSAEERKAWTNKAKGETASDGAEAKKRKRVVSEICETENQEETVKENLDLSKKQKALNLPANQKLSAFAFKQ", "length": 1117 }, "evidence": [ { "id": "E1B7F5", "url": "https://omabrowser.org/oma/group/E1B7F5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q01454-1", "protein_name": "DNA polymerase alpha-binding protein", "gene_name": "CTF4", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MVSVIDKLVFDFGGKTLVSLAPDNNTLCVANKNGLTKILKTNNPEEEPETLDSSKLVSSIKCYSNSHFLMTTMQGDALRYNIDSSQEELLARFALPLRDCCVIHSGKMAVFGGDDLELILLELDDETHKKHAIKIDEQVSQISYNSQMNILAVSMINGKVQIFSLTSTIPNKVHELNDYIVANSYDDTHRDKILSNMMDDIDKDNDNDLSETADPDENNVADPEFCAANRICTRVAWHPKGLHFALPCADDTVKIFSIKGYSLQKTLSTNLSSTKAHFIDLQFDPLRGTYIAAVDLNNKLTVWNWETSEIHYTREFKRKITNIAWKIQADSKTLDLVLGTWSGSIAIVQNLAESVVSNIPDQSVAESSTKHGLFVDSESDLENLEGNDDINKSDKLFSDITQEANAEDVFTQTHDGPSGLSEKRKYNFEDEEDFIDDDDGAGYISGKKPHNEHSYSRVHKTHSFPISLANTGKFRYMPFSPAGTPFGFTDRRYLTMNEVGYVSTVKNSEQYSITVSFFDVGRFREYHFEDLFGYDLCFLNEKGTLFGQSKTGQIQYRPHDSIHSNWTKIIPLQAGERITSVAATPVRVIVGTSLGYFRSFNQFGVPFAVEKTSPIVALTAQNYRVFSVHYSQFHGLSYSLSELGTSSKRYYKRECPLPMSLPNINSDMKKDANLDYYNFNPMGIKSLFFSSYGDPCIFGSDNTLLLLSKWRSPEESKWLPILDSNMEIWKMSGGKETTDIHVWPLALAYDTLNCILVKGKHIWPEFPLPLPSEMEIRMPVFVKSKLLEENKAILNKKNEIGADTEAEEGEEDKEIQIPVSMAAEEEYLRSKVLSELLTDTLENDGEMYGNENEVLAALNGAYDKALLRLFASACSDQNVEKALSLAHELKQDRALTAAVKISERAELPSLVKKINNIREARYEQQLK", "length": 927 }, "evidence": [ { "id": "E1B7F5", "url": "https://omabrowser.org/oma/group/E1B7F5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1B7F5", "url": "https://www.uniprot.org/uniprotkb/E1B7F5" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "E1B7F5", "url": "https://www.uniprot.org/uniprotkb/E1B7F5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1B7F5", "url": "https://www.uniprot.org/uniprotkb/E1B7F5" } ], "pmid": "" }, { "name": "nuclear replication fork", "id": "GO:0043596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043596", "evidence": [ { "database": "UniProtKB", "id": "E1B7F5", "url": "https://www.uniprot.org/uniprotkb/E1B7F5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated DNA replication", "id": "GO:0006261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006261", "evidence": [ { "database": "UniProtKB", "id": "E1B7F5", "url": "https://www.uniprot.org/uniprotkb/E1B7F5" } ], "pmid": "" }, { "name": "mitotic cell cycle", "id": "GO:0000278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", "evidence": [ { "database": "UniProtKB", "id": "E1B7F5", "url": "https://www.uniprot.org/uniprotkb/E1B7F5" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "E1B7F5", "url": "https://www.uniprot.org/uniprotkb/E1B7F5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1028, "end_pos": 1030, "annotation": "n_glycosylation_sequon" }, { "start_pos": 340, "end_pos": 342, "annotation": "n_glycosylation_sequon" }, { "start_pos": 485, "end_pos": 487, "annotation": "n_glycosylation_sequon" }, { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" }, { "start_pos": 845, "end_pos": 847, "annotation": "n_glycosylation_sequon" }, { "start_pos": 940, "end_pos": 942, "annotation": "n_glycosylation_sequon" }, { "start_pos": 999, "end_pos": 1001, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7F5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1127, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7F5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7F5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7F5" }, { "id": "PS50118", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50118" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HMG box", "eco_id": "ECO_0000259", "start_pos": 1014, "end_pos": 1083, "start_aa": "Asn", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 426 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1028, "end_pos": 1030 }, { "start_pos": 340, "end_pos": 342 }, { "start_pos": 485, "end_pos": 487 }, { "start_pos": 73, "end_pos": 75 }, { "start_pos": 845, "end_pos": 847 }, { "start_pos": 940, "end_pos": 942 }, { "start_pos": 999, "end_pos": 1001 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B883-1", "uniprot_ac": "E1B883", "uniprot_id": "E1B883_BOVIN", "mass": { "chemical_mass": 74515.0, "monoisotopic_mass": 74515.0 }, "refseq": {}, "gene_names": [ { "name": "RRN3", "type": "recommended", "evidence": [ { "id": "E1B883", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B883" } ] } ], "protein_names": [ { "name": "RRN3 homolog, RNA polymerase I transcription factor", "type": "synonym", "evidence": [ { "id": "E1B883", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B883/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B883", "url": "https://www.uniprot.org/uniprotkb/E1B883" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RRN3", "url": "https://www.uniprot.org/uniprotkb/E1B883", "locus": { "chromosome": "25", "start_pos": 13714338, "end_pos": 13686004, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004804", "url": "https://www.ensembl.org/id/ENSBTAG00000004804" } ] } } ], "crossref": [ { "id": "E1B883", "url": "https://alphafold.ebi.ac.uk/entry/E1B883", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004804", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004804", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR007991", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007991", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B883", "url": "https://www.orthodb.org/?gene=E1B883", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12790", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12790", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12790:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12790:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05327", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05327", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-73762", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73762", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-73772", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73772", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TYQ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYQ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYQ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYQ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B883", "url": "https://www.uniprot.org/uniprotkb/E1B883", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B883-1", "url": "https://www.uniprot.org/uniprotkb/E1B883-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPLLHTRFPGDAAASGSAVKTLGSPRTGLSDMLALENDFFSSPPRKTVRFGGTVTEVLLKYKKGETNDFELLKNQLSDPEIKDDQIINWLLEFRSSIMYLTKDFEQLINILLRLKWLNRSQTVVEEYLSFLGNLVSAQTVFLRPCLSMIASHFVPPRVVIKEGDVDVSDSDDEDENLPANFDTCHRALQIIARYVPSTPWFLMPILVEKFPFVRKSERTLECYIHNLLRISVYFPTLRHEILELVVEKLLKLDVNASRQDIEDAEETAAQTGGGADATEALFNMDEDEEADHETKADPGRLDQMVHPMAERLDILLSLLLSYIKDVCYVDGKIDNNKTKDLYRDLITIFDKLLLPTHASCHVQFFMFYLCSFKLGFAEAFLEHLWKKLQDPNNPAIIRQAAANYIGSFLARAKFIPLMFVIFHLHSESIVSVKAEEKKSPLKDSGTKAFCDVALHGPFYSACQAVFYTFVFRHKQLLSGNLKEGLRYLQSLNFERIVMSQLNPLKICLPSVVNFFAAITNKYQLVFCYTLIERNNRQMLPVIRNTAGGDSVQTCTNPLDTFFPFDPCVLKRSKKFIDPLYQIWEDMSAEELQEFKKPIKKEVVEDEEDDFLKGEVGITPSSFDAHFRSPSSSVGSPPVLYLPDQSPLVTRICD", "length": 655, "header": "tr|E1B883-1|E1B883_BOVIN Isoform 1 of RRN3 homolog, RNA polymerase I transcription factor OS=Bos taurus OX=9913 GN=RRN3 PE=3 SV=4 CANONICAL=E1B883-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TYQ4-1", "url": "https://www.uniprot.org/uniprotkb/E1B883/entry#A0AAA9TYQ4-1", "sequence": { "sequence": "MAAPLLHTRFPGDAAASGSAVKTLGSPRTGLSDMLALENDFFSSPPRKTVRFGGTVTEVLLKYKKGETNDFELLKNQLSDPEIKDDQIINWLLEFRSSIMYLTKDFEQLINILLRLKWLNRSQTVVEEYLSFLGNLVSAQTVFLRPCLSMIASHFVPPRVVIKEGDVDVSDSDDEDENLPANFDTCHRALQIIARYVPSTPWFLMPILVEKFPFVRKSERTLECYIHNLLRISVYFPTLRHEILELVVEKLLKLDVNASRQDIEDAEETAAQTGGGADATEALFNMDEDEEADHETKADPGRLDQMVHPMAERLDILLSLLLSYIKDVCYVDGKIDNNKTKDLYRDLITIFDKLLLPTHASCHVQFFMFYLCSFKLGFAEAFLEHLWKKLQDPNNPAIIRQAAANYIGSFLARAKFIPLITVKSCLDLLVNWLHVYLNNQDSGTKAFCDVALHGPFYSACQAVFYTFVFRHKQLLSGNLKEGLRYLQSLNFERIVMSQLNPLKICLPSVVNFFAAITNKYQLVFCYTLIERNNRQMLPVIRNTAGGDSVQTCTNPLDTFFPFDPCVLKRSKKFIDPLYQIWEDMSAEELQEFKKPIKKEVVEDEEDDFLKGEVGITPSSFDAHFRSPSSSL", "length": 631, "header": "tr|A0AAA9TYQ4-1|E1B883_BOVIN Computationally mapped isoform of RRN3 homolog, RNA polymerase I transcription factor OS=Bos taurus OX=9913 GN=RRN3 PE=3 SV=1 CANONICAL=E1B883-1" }, "locus": { "chromosome": "25", "start_pos": 13713974, "end_pos": 13686276, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120271.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120271.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103766.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103766.1" } ] } }, { "isoform_ac": "E1B883-1", "url": "https://www.uniprot.org/uniprotkb/E1B883/entry#E1B883-1", "sequence": { "sequence": "MAAPLLHTRFPGDAAASGSAVKTLGSPRTGLSDMLALENDFFSSPPRKTVRFGGTVTEVLLKYKKGETNDFELLKNQLSDPEIKDDQIINWLLEFRSSIMYLTKDFEQLINILLRLKWLNRSQTVVEEYLSFLGNLVSAQTVFLRPCLSMIASHFVPPRVVIKEGDVDVSDSDDEDENLPANFDTCHRALQIIARYVPSTPWFLMPILVEKFPFVRKSERTLECYIHNLLRISVYFPTLRHEILELVVEKLLKLDVNASRQDIEDAEETAAQTGGGADATEALFNMDEDEEADHETKADPGRLDQMVHPMAERLDILLSLLLSYIKDVCYVDGKIDNNKTKDLYRDLITIFDKLLLPTHASCHVQFFMFYLCSFKLGFAEAFLEHLWKKLQDPNNPAIIRQAAANYIGSFLARAKFIPLMFVIFHLHSESIVSVKAEEKKSPLKDSGTKAFCDVALHGPFYSACQAVFYTFVFRHKQLLSGNLKEGLRYLQSLNFERIVMSQLNPLKICLPSVVNFFAAITNKYQLVFCYTLIERNNRQMLPVIRNTAGGDSVQTCTNPLDTFFPFDPCVLKRSKKFIDPLYQIWEDMSAEELQEFKKPIKKEVVEDEEDDFLKGEVGITPSSFDAHFRSPSSSVGSPPVLYLPDQSPLVTRICD", "length": 655, "header": "tr|E1B883-1|E1B883_BOVIN Isoform 1 of RRN3 homolog, RNA polymerase I transcription factor OS=Bos taurus OX=9913 GN=RRN3 PE=3 SV=4 CANONICAL=E1B883-1" }, "locus": { "chromosome": "25", "start_pos": 13712511, "end_pos": 13686276, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006308.8", "url": "https://www.ensembl.org/id/ENSBTAT00000006308.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006308.7", "url": "https://www.ensembl.org/id/ENSBTAP00000006308.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-73762", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73762", "resource": "Reactome", "description": "RNA Polymerase I Transcription Initiation" }, { "id": "R-BTA-73772", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73772", "resource": "Reactome", "description": "RNA Polymerase I Promoter Escape" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "transcription initiation at RNA polymerase I promoter", "id": "GO:0006361", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006361", "evidence": [ { "database": "UniProtKB", "id": "E1B883", "url": "https://www.uniprot.org/uniprotkb/E1B883" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA polymerase I general transcription initiation factor activity", "id": "GO:0001181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001181", "evidence": [ { "database": "UniProtKB", "id": "E1B883", "url": "https://www.uniprot.org/uniprotkb/E1B883" } ], "pmid": "" }, { "name": "RNA polymerase I core binding", "id": "GO:0001042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001042", "evidence": [ { "database": "UniProtKB", "id": "E1B883", "url": "https://www.uniprot.org/uniprotkb/E1B883" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B883", "url": "https://www.uniprot.org/uniprotkb/E1B883" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" }, { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 338, "end_pos": 340, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B883-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 655, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B883-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B883" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 120, "end_pos": 122 }, { "start_pos": 257, "end_pos": 259 }, { "start_pos": 338, "end_pos": 340 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1BDA1-1", "uniprot_ac": "E1BDA1", "uniprot_id": "E1BDA1_BOVIN", "mass": { "chemical_mass": 93572.0, "monoisotopic_mass": 93572.0 }, "refseq": {}, "gene_names": [ { "name": "BRMS1", "type": "recommended", "evidence": [ { "id": "E1BDA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDA1" } ] }, { "name": "RIN1", "type": "recommended", "evidence": [ { "id": "E1BDA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDA1" } ] }, { "name": "BRMS1", "type": "synonym", "evidence": [ { "id": "E1BDA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDA1" } ] } ], "protein_names": [ { "name": "BRMS1 transcriptional repressor and anoikis regulator", "type": "synonym", "evidence": [ { "id": "E1BDA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDA1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BDA1", "url": "https://www.uniprot.org/uniprotkb/E1BDA1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RIN1", "url": "https://www.uniprot.org/uniprotkb/E1BDA1", "locus": {} } ], "crossref": [ { "id": "E1BDA1", "url": "https://alphafold.ebi.ac.uk/entry/E1BDA1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017681", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017681", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10393", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10393", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037191", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037191", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045046", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045046", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BDA1", "url": "https://www.orthodb.org/?gene=E1BDA1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21964", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21964", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23101", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23101", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23101:SF62", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23101:SF62", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02204", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02204", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08598", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08598", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23268", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23268", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6Z4R2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z4R2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z4R2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDA1", "url": "https://www.uniprot.org/uniprotkb/E1BDA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDA1-1", "url": "https://www.uniprot.org/uniprotkb/E1BDA1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVLSQSNILSLDLGLQSLSWVPLHRNSEPEIIFEGPACPGCCWSDKEVLLTTGNVSALALGAGFSESRERLEELPAMDTPREPGTGPLGTPYPASFASGHLEREKPAQDPRYDVPGAGGVQAGGSQRPGRTVSLRERLLLTRPVWLQLRANEAAALHVLRTEPPGTFLVRKSNSRQCQALCVRLPEASGPSFVSSHCIQETAEGVSLEGSELVFLDLVQLICAYCHTRDILLLPLQLPRAIRQAATHKELEAISHLGMEFWSSSLNTKAQPGPSEGPPLPRLKPRPPQELDQGTGAALCFFNPLFPGDLGHTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGTVPNQTERLPPRQLLRRESSVGYRVPGGAGPSLPPLPSLQEVDCASPSSSEEEGGVPGSQGSPATSPHLGYRRRRRPLLRSMSAAFCSLLAPERQVGRAAAALTQDRHTAVGQLVQDLLTQVRASPEPRELQAVREALSRARAMLSAELSPEKLLSPDRLEQVLEKSLHRSVLKPLRPILVARLRHRLSANSSLGRLAEGLRLARARGASAFGSHLSLPSPVEMEQVRQKLLQLLRAYSPSAQVKRLLQACKLLYTALRTQAGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPALLTGEGGYYLTSLSASLALLSGLTEAHTLPLSPSQELQRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNKLCATKFRVTHPDTFGLFLYKGQDYQRLPPGALAHRLPTAGYLVYRRAEQPETPGASPGAATGEGSGGPEAGDREEDKEGRGTGETKAKTSPRDGRGESETVAEGAEDQARGDPTQPRGPETEESQAAEE", "length": 867, "header": "tr|E1BDA1-1|E1BDA1_BOVIN Isoform 1 of BRMS1 transcriptional repressor and anoikis regulator OS=Bos taurus OX=9913 GN=RIN1 PE=3 SV=3 CANONICAL=E1BDA1-1" }, "isoforms": [ { "isoform_ac": "A0AAF6Z4R2-1", "url": "https://www.uniprot.org/uniprotkb/E1BDA1/entry#A0AAF6Z4R2-1", "sequence": { "sequence": "MPVQPPSKDTEEMEAEGDSAAEMNGEEEESEEERSGSQTESEEESSEMDEEDCERRRSECVSEMMDLEKQFSELKEKLFRERLSQLRVRLEEVGAERAPEYTEPLGGLQRSLKIRIQVAGIYKGFCLDVIRNKYECELQGAKQHLESEKLLLYDTLQGELQERIQRLEEDRQSLDISSGDRHPGGLDGHQKGEGSCVPSEEKIRWTLTLLFTARGAPWSSWHQTQDWNFPAAERQTGRPLGVCPAISPVLLQGPPLQPSLVWAPPLPSLGPEQPRPGAARGWPDGLLPPQPAHHHPLPKVALLGALPDEDMPVLSQSNILSLDLGLQSLSWVPLHRNSEPEIIFEGPACPGCCWSDKAGSLGLPSRGGSWCLPPTFQGLELKPFLGLWHDPPVSNLPCKGIRTLVESA", "length": 408, "header": "tr|A0AAF6Z4R2-1|E1BDA1_BOVIN Computationally mapped isoform of BRMS1 transcriptional repressor and anoikis regulator OS=Bos taurus OX=9913 GN=RIN1 PE=3 SV=1 CANONICAL=E1BDA1-1" }, "locus": { "chromosome": "29", "start_pos": 44393931, "end_pos": 44389671, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023526.5", "url": "https://www.ensembl.org/id/ENSBTAT00000023526.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023526.4", "url": "https://www.ensembl.org/id/ENSBTAP00000023526.4" } ] } }, { "isoform_ac": "E1BDA1-1", "url": "https://www.uniprot.org/uniprotkb/E1BDA1/entry#E1BDA1-1", "sequence": { "sequence": "MPVLSQSNILSLDLGLQSLSWVPLHRNSEPEIIFEGPACPGCCWSDKEVLLTTGNVSALALGAGFSESRERLEELPAMDTPREPGTGPLGTPYPASFASGHLEREKPAQDPRYDVPGAGGVQAGGSQRPGRTVSLRERLLLTRPVWLQLRANEAAALHVLRTEPPGTFLVRKSNSRQCQALCVRLPEASGPSFVSSHCIQETAEGVSLEGSELVFLDLVQLICAYCHTRDILLLPLQLPRAIRQAATHKELEAISHLGMEFWSSSLNTKAQPGPSEGPPLPRLKPRPPQELDQGTGAALCFFNPLFPGDLGHTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGTVPNQTERLPPRQLLRRESSVGYRVPGGAGPSLPPLPSLQEVDCASPSSSEEEGGVPGSQGSPATSPHLGYRRRRRPLLRSMSAAFCSLLAPERQVGRAAAALTQDRHTAVGQLVQDLLTQVRASPEPRELQAVREALSRARAMLSAELSPEKLLSPDRLEQVLEKSLHRSVLKPLRPILVARLRHRLSANSSLGRLAEGLRLARARGASAFGSHLSLPSPVEMEQVRQKLLQLLRAYSPSAQVKRLLQACKLLYTALRTQAGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELLEPALLTGEGGYYLTSLSASLALLSGLTEAHTLPLSPSQELQRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNKLCATKFRVTHPDTFGLFLYKGQDYQRLPPGALAHRLPTAGYLVYRRAEQPETPGASPGAATGEGSGGPEAGDREEDKEGRGTGETKAKTSPRDGRGESETVAEGAEDQARGDPTQPRGPETEESQAAEE", "length": 867, "header": "tr|E1BDA1-1|E1BDA1_BOVIN Isoform 1 of BRMS1 transcriptional repressor and anoikis regulator OS=Bos taurus OX=9913 GN=RIN1 PE=3 SV=3 CANONICAL=E1BDA1-1" }, "locus": { "chromosome": "29", "start_pos": 44389964, "end_pos": 44384100, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023514.5", "url": "https://www.ensembl.org/id/ENSBTAT00000023514.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023514.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023514.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8876198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "resource": "Reactome", "description": "RAB GEFs exchange GTP for GDP on RABs" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BDA1", "url": 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"ENSBTAP00000012291.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012291.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:532062", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532062", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LV36-1", "protein_name": "PNMA family member 8A", "gene_name": "Pnma8a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSEPMAMNLLEDWCRGMGMDIHRSLLVTGIPEHCGHAEIEETLNGVLLPLGTYRILNKMFLRQENVKAALVEVSEGVNLSSVPREFPGRGGVWRVVYRDPTQDDEFLKNLNEFLDAEGRTWEDVVRLLRLNPNPPLPNSNQPPPNWAEALGLLLGVVVQVIFYMDAAIRNREEEARAEEAAEAELMEAWASTARRRVKKEPGLGVEVGSTFKMEDRNHWKNTEDHGEPPKPLVRRAGGKIRSRRRKQKKNPKQEPICWRKPQGSNYNKSNLEAGEATATQSSEVSESAKNNKNPFVKQEETVWKKKRVWRDPNDFPRSALPTADSPGNLEDSDQDGGPENPPKKKAMTWASNRIPAPMRKKKKMSLGALSYVLVDSEATKNKTVIPKKGPGSTRSVSVPQGTQPDDALASTSRAQKTKPGGLPRVSKGECVQRWLG", "length": 436 }, "evidence": [ { "id": "A7E321", "url": "https://omabrowser.org/oma/group/A7E321/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80VM8-1", "protein_name": "Paraneoplastic antigen-like protein 8A", "gene_name": "Pnma8a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSEPVAMTLLEDWCRGMGMDIHRSLLVTGIPEYCSHAEIEETLNGVLLPLGTYRVLNKIFLRQENVKAALVEVSEGVNLSSIPREFPGRGGVWRVVCRDPTQDDDFLKNLNEFLDGEGRTWEDMVRLLKLNPNPPLPNSNQPPPNWAEALGLLLGAVVQVIFYMDAAIRSRDEEARAEEAAEAELMEAWASTARKRVKKEPGLGVEVGSAFKMEDRNYWKNTEDHGDPPKPLVRRPGGKIRSRRRKQKKNLKQEPICWRKSQGSNYNSNYNKVNLEAGEAAQSSEIPESVKSNKKPFVKQEETVWKKKRVWRDPSDLPRSALPAADSPGNLEDSDQDGGPENPAKKKAMTWASNKIPVPTRKKKKMVSLGTLSYVLLDAEATKNKTAILKKGLGARRAVSVPHDAPASTSRPQKTKLGAFPRVSKDSRKL", "length": 430 }, "evidence": [ { "id": "A7E321", "url": "https://omabrowser.org/oma/group/A7E321/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86V59-1", "protein_name": "Paraneoplastic antigen-like protein 8A", "gene_name": "PNMA8A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSKTMAMNLLEDWCRGMEVDIHRSLLVTGIPEDCGQAEIEETLNGVLSPLGPYRVLNKIFVREENVKAALIEVGEGVNLSTIPREFPGRGGVWRVVCRDPTQDAEFLKNLNEFLDAEGRTWEDVVRLLQLNHPTLSQNQHQPPENWAEALGVLLGAVVQIIFCMDAEIRSREEARAQEAAEFEEMAAWALAAGRKVKKEPGLAAEVGSALKAETPNNWNATEDQHEPTKPLVRRAGAKSRSRRKKQKKNSRQEAVPWKKPKGINSNSTANLEDPEVGDAESMAISEPIKGSRKPCVNKEELALKKPMAKCAWKGPREPPQDARAEAESPGGASESDQDGGHESPPKKKAVAWVSAKNPAPMRKKKKVSLGPVSYVLVDSEDGRKKPVMPKKGPGSRREASDQKAPRGQQPAEATASTSRGPKAKPEGSPRRATNESRKV", "length": 439 }, "evidence": [ { "id": "A7E321", "url": "https://omabrowser.org/oma/group/A7E321/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7E321-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 471, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7E321-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7E321" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 138, "end_pos": 140 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 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"NP_001181959", "name": "UPF0524 protein C3orf70 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181959" }, "gene_names": [ { "name": "C1H3orf70", "type": "synonym", "evidence": [ { "id": "NP_001181959", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181959" } ] } ], "protein_names": [ { "name": "UPF0524 protein C3orf70 homolog", "type": "recommended", "evidence": [ { "id": "A7E369", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E369/entry#names_and_taxonomy" } ] }, { "name": "UPF0524 protein C3orf70 homolog", "type": "synonym", "evidence": [ { "id": "NP_001181959", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181959" } ] } ], "function": [ { "annotation": "May play a role in neuronal and neurobehavioral development.", "evidence": [ { "database": "UniProtKB", "id": "A7E369", "url": "https://www.uniprot.org/uniprotkb/A7E369#function" }, { "database": "UniProtKB", "id": "Q1LY84", "url": "https://www.uniprot.org/uniprotkb/Q1LY84#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7E369", "url": "https://www.uniprot.org/uniprotkb/A7E369" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A7E369", "locus": {} } ], "crossref": [ { "id": "A7E369", "url": "https://alphafold.ebi.ac.uk/entry/A7E369", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005212", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005212", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615631", "url": "https://www.ncbi.nlm.nih.gov/gene/615631", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029670", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029670", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615631", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615631", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GAHKCPK", "url": "https://omabrowser.org/oma/group/GAHKCPK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A7E369", "url": "https://www.orthodb.org/?gene=A7E369", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31785", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31785", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31785:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31785:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15823", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15823", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001181959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181959", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A7E369", "url": "https://www.uniprot.org/uniprotkb/A7E369", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7E369-1", "url": "https://www.uniprot.org/uniprotkb/A7E369-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAAAAPAPERGWKSEKVDEAQALARSCAARRPDFQPCDGLSICATHSHGKCFKLHWCCHLGWCHCKYVYQPMTPVEQLPSTEIPAKPREPANTIQISVSLTEHFLKFASVFQPPLPPDSPRYCMISDLFIDNYQVKCINGKMCYVQKQPAPHSHKMSPEEVSAHDAFISKESNTPKIDHCSSPSSSEDSGINAIGAHYVESCDEDTEEGAELSSEEDYSPESSWEPDECTLLSPSQSDLEVIETIETTV", "length": 250, "header": "sp|A7E369-1|CC070_BOVIN Isoform 1 of UPF0524 protein C3orf70 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=2 CANONICAL=A7E369-1" }, "isoforms": [ { "isoform_ac": "A7E369-1", "url": "https://www.uniprot.org/uniprotkb/A7E369/entry#A7E369-1", "sequence": { "sequence": "MSAAAAPAPERGWKSEKVDEAQALARSCAARRPDFQPCDGLSICATHSHGKCFKLHWCCHLGWCHCKYVYQPMTPVEQLPSTEIPAKPREPANTIQISVSLTEHFLKFASVFQPPLPPDSPRYCMISDLFIDNYQVKCINGKMCYVQKQPAPHSHKMSPEEVSAHDAFISKESNTPKIDHCSSPSSSEDSGINAIGAHYVESCDEDTEEGAELSSEEDYSPESSWEPDECTLLSPSQSDLEVIETIETTV", "length": 250, "header": "sp|A7E369-1|CC070_BOVIN Isoform 1 of UPF0524 protein C3orf70 homolog OS=Bos taurus OX=9913 GN= PE=2 SV=2 CANONICAL=A7E369-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615631", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615631", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2UF71-1", "protein_name": "Chromosome 3 open reading frame 70", "gene_name": "C3orf70", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGAAAAKSEKLDEAQALARSCAGRPDFQPCDGLSLCATHSHGRCFRLHWCCHLGWCHCKYVYQPMTPVEQLPSTEIPVRPRESTNTIQISVSLTEHFLKFAPVFQPPLPPDSPQFCTIADLFIDNYRVKCINGKMCYVQRQPPPVPHKTKPEEVSVRNALITKESNTPKTDHCSSPSSSEDSGINAVGVHYMESCDEDTEGVAELSSEEDYSPDSSWEPDECPLLSPSQCEMEVIETIETTV", "length": 243 }, "evidence": [ { "id": "A7E369", "url": "https://omabrowser.org/oma/group/A7E369/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A4X1UIT0-1", "protein_name": "Chromosome 13 C3orf70 homolog", "gene_name": "C3orf70", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSAAAAPVSERGWKSEKVDEAQALARSCAARRPDFQPCDGLSICATHSHGKCFKLHWCCHLGWCHCKYVYQPMTPVEQLPSTEIPAKPREPTNTIQISVSLTEHFLKFASVFQPPLPPDSPRYCMISDLFIDNYQVKCINGKMCYVQKQPAPHSHKMSPEEVSAHDALISKESNTPKIDHCSSPSSSEDSGINAIGAHYVESCDEDTEEGAELSSEEDYSPESSWEPDECTLLSPSQSDLEVIETIETTV", "length": 250 }, "evidence": [ { "id": "A7E369", "url": "https://omabrowser.org/oma/group/A7E369/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6A3M1-1", "protein_name": "Similar to human chromosome 3 open reading frame 70", "gene_name": "C11h3orf70", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSAATAPERGWKSEKVDEAQALARSCAARRPDFQPCDGLSICATHSHGKCFKLHWCCHLGWCHCKYVYQPMTPVGQLPSTEIPARPREPTNTIQISVSLTEHFLKFASVFQPPLPPDSPRYCMISDLFIDNYQVKCINGKMCYVQKQPHSQKMSPEEVSAHDALISKESDTPKLGHCSSPSGSEDSGINAIGAHYVESCDEDTEEGAELSSEEDYSPESSWEPDECTLLSPSQSDLEVIETMETTV", "length": 246 }, "evidence": [ { "id": "A7E369", "url": "https://omabrowser.org/oma/group/A7E369/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A3KNX6-1", "protein_name": "UPF0524 protein C3orf70 homolog B", "gene_name": "c3orf70b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAYSGAQKALKSDKLDEAQALAKSCAGRPDFLPCDGLSICATHSHGKCFKLHWCCYLGWCHCKYVYQPMTNVAQLPSTPVPAAPSDCPDTIDLSISLTERFLRISPCFQAPPCPESPKYCNIAELFIDDYIVKRINGKMCYVQRPQAHVEPAQMNPIQKQHTEDKQIVEETVKGPKMGHCSSPSTSEDSGINALGGHFLESCEEESEEEDELSTDGHSSPGSLWDQDECTLLSPSKSMVEIIENIETTV", "length": 249 }, "evidence": [ { "id": "A7E369", "url": "https://omabrowser.org/oma/group/A7E369/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A6NLC5-1", "protein_name": "UPF0524 protein C3orf70", "gene_name": "C3orf70", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSAAASPASERGWKSEKLDEAQALARSCAARRPDFQPCDGLSICATHSHGKCFKLHWCCHLGWCHCKYMYQPMTPVEQLPSTEIPARPREPTNTIQISVSLTEHFLKFASVFQPPLPPDSPRYCMISDLFIDNYQVKCINGKMCYVQKQPAPHSHRMSPEEVSAHDALISKESNTPKIDHCSSPSSSEDSGINAIGAHYVESCDEDTEEGAELSSEEDYSPESSWEPDECTLLSPSQSDLEVIETIETTV", "length": 250 }, "evidence": [ { "id": "A7E369", "url": "https://omabrowser.org/oma/group/A7E369/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6GQU0-1", "protein_name": "UPF0524 protein C3orf70 homolog", "gene_name": "", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAATAPERGWKSEKVDEAQALARSCAARRPDFQPCDGLSICATHSHGKCFKLHWCCHLGWCHCKYVYQPMTPVEQLPSTEIPAKPREPTNTIQISVSLTEHFLKFASVFQPPLPPDSPRYCMISDLFIDNYQVKCINGKMCYVQKQQAPHSQKMSPEEVSAHDALISKESDTPKLGHCSSPSGSEDSGINAIGAHYVESCDEDTEEGAELSSEEDYSPESSWEPDECTLLSPSQSDLEVIETMETTV", "length": 248 }, "evidence": [ { "id": "A7E369", "url": "https://omabrowser.org/oma/group/A7E369/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A7E369", "url": "https://www.uniprot.org/uniprotkb/A7E369" } ], "pmid": "" }, { "name": "circadian behavior", "id": "GO:0048512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048512", "evidence": [ { "database": "UniProtKB", "id": "A7E369", "url": "https://www.uniprot.org/uniprotkb/A7E369" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7E369-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 250, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7E369-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7E369" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A7E379-1", "uniprot_ac": "A7E379", "uniprot_id": "PTPC1_BOVIN", "mass": { "chemical_mass": 89386.0, "monoisotopic_mass": 89386.0 }, "refseq": { "ac": "NP_001193525", "name": "protein tyrosine phosphatase domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193525" }, "gene_names": [ { "name": "PTPDC1", "type": "recommended", "evidence": [ { "id": "A7E379", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E379" } ] }, { "name": "PTPDC1", "type": "synonym", "evidence": [ { "id": "NP_001193525", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193525" } ] } ], "protein_names": [ { "name": "Protein tyrosine phosphatase domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A7E379", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E379/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.-", "type": "synonym", "evidence": [ { "id": "A7E379", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E379/entry#names_and_taxonomy" } ] }, { "name": "protein tyrosine phosphatase domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001193525", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193525" } ] } ], "function": [ { "annotation": "May play roles in cilia formation and/or maintenance.", "evidence": [ { "database": "UniProtKB", "id": "A7E379", "url": "https://www.uniprot.org/uniprotkb/A7E379#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7E379", "url": "https://www.uniprot.org/uniprotkb/A7E379" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTPDC1", "url": "https://www.uniprot.org/uniprotkb/A7E379", "locus": { "chromosome": "8", "start_pos": 85382672, "end_pos": 85312669, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005803", "url": "https://www.ensembl.org/id/ENSBTAG00000005803" } ] } } ], "crossref": [ { "id": "A7E379", "url": "https://alphafold.ebi.ac.uk/entry/A7E379", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd14506", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14506", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "519311", "url": "https://www.ncbi.nlm.nih.gov/gene/519311", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049573", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049573", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050561", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050561", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519311", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519311", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A7E379", "url": "https://www.orthodb.org/?gene=A7E379", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23339", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23339", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00782", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00782", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193525", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A7E379", "url": "https://www.uniprot.org/uniprotkb/A7E379", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7E379-1", "url": "https://www.uniprot.org/uniprotkb/A7E379-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQDPPRRLSAVPFLSSFFEGRRHSASDPILRLQQGRRSSAAKVLSSSSLQVMVAMSSVSCAERNPTCPERKRNSGRPTPKYTKVGERLRHVIPGHVACSMACGGKACKYENAARWSEQEQAVKGIYSSWVTDNILAMARPSTEVLEKFCIIEQFRSHGIKSIINLQRPGEHASCGNPLEQESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFALQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLIPLRNIFSCCDPKAHAVTLAQYLIRQRHLLHGYEARLLKHIPKIIHLVCKLLLDLAENRPVVTEVADIPGLSAEIEKTVSEMITRQLDKELLRHDSDASDSFTPTAVVMDFENQDVVLSSEQELDPLWKRRNVECLQPLAHLKRQLSYSDSDLKRAESLLEQGRTPWTVPAQALLCHNPRQQKHISRCYSPQSPQLDLNKETLVRNTFSFWNHTKFGVPEGLKDDGSLIFHRTSIPKEVQRSRTFSSGISDSYNPGEPVTPNSANIPKGPNSSQQKVYHCECESHGGCGPSSVAEDGETCRRPVDCGSSPKAQFLGNETQNSKYLSEVAAHMPLQSELSVEARRILAAKALANLNEIAEKEEVKKKVEMWQKELNSRDGAWERICGEKDPFILCSLMWSWVEQLKEPVITKEDMDMLVDRCADASEALFLLEKGQQQTILCVLHCIVSLQTIPADVEEAVLARAIKAFTKVNFDSENGPIVYNTLKKIFKRTLEEKRKMTKDNPEPGI", "length": 796, "header": "sp|A7E379-1|PTPC1_BOVIN Isoform 1 of Protein tyrosine phosphatase domain-containing protein 1 OS=Bos taurus OX=9913 GN=PTPDC1 PE=2 SV=2 CANONICAL=A7E379-1" }, "isoforms": [ { "isoform_ac": "A7E379-1", "url": "https://www.uniprot.org/uniprotkb/A7E379/entry#A7E379-1", "sequence": { "sequence": "MQDPPRRLSAVPFLSSFFEGRRHSASDPILRLQQGRRSSAAKVLSSSSLQVMVAMSSVSCAERNPTCPERKRNSGRPTPKYTKVGERLRHVIPGHVACSMACGGKACKYENAARWSEQEQAVKGIYSSWVTDNILAMARPSTEVLEKFCIIEQFRSHGIKSIINLQRPGEHASCGNPLEQESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFALQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLIPLRNIFSCCDPKAHAVTLAQYLIRQRHLLHGYEARLLKHIPKIIHLVCKLLLDLAENRPVVTEVADIPGLSAEIEKTVSEMITRQLDKELLRHDSDASDSFTPTAVVMDFENQDVVLSSEQELDPLWKRRNVECLQPLAHLKRQLSYSDSDLKRAESLLEQGRTPWTVPAQALLCHNPRQQKHISRCYSPQSPQLDLNKETLVRNTFSFWNHTKFGVPEGLKDDGSLIFHRTSIPKEVQRSRTFSSGISDSYNPGEPVTPNSANIPKGPNSSQQKVYHCECESHGGCGPSSVAEDGETCRRPVDCGSSPKAQFLGNETQNSKYLSEVAAHMPLQSELSVEARRILAAKALANLNEIAEKEEVKKKVEMWQKELNSRDGAWERICGEKDPFILCSLMWSWVEQLKEPVITKEDMDMLVDRCADASEALFLLEKGQQQTILCVLHCIVSLQTIPADVEEAVLARAIKAFTKVNFDSENGPIVYNTLKKIFKRTLEEKRKMTKDNPEPGI", "length": 796, "header": "sp|A7E379-1|PTPC1_BOVIN Isoform 1 of Protein tyrosine phosphatase domain-containing protein 1 OS=Bos taurus OX=9913 GN=PTPDC1 PE=2 SV=2 CANONICAL=A7E379-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 435, "end_pos": 435, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7E379", "url": "https://www.uniprot.org/uniprotkb/A7E379" } ], "site_lbl": "Ser435" }, { "start_pos": 437, "end_pos": 437, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7E379", "url": "https://www.uniprot.org/uniprotkb/A7E379" } ], "site_lbl": "Ser437" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:519311", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519311", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A7E379", "url": "https://www.uniprot.org/uniprotkb/A7E379" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A7E379", "url": "https://www.uniprot.org/uniprotkb/A7E379" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "A7E379", "url": "https://www.uniprot.org/uniprotkb/A7E379" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 500, "end_pos": 502, "annotation": "n_glycosylation_sequon" }, { "start_pos": 559, "end_pos": 561, "annotation": "n_glycosylation_sequon" }, { "start_pos": 605, "end_pos": 607, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7E379-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 796, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7E379-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7E379" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A7E379", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E379" }, { "id": "PRU00160", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00160" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tyrosine-protein phosphatase", "eco_id": "ECO_0000255", "start_pos": 126, "end_pos": 297, "start_aa": "Tyr", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 435, 437 ], "sequon_annotation_sites": [ { "start_pos": 500, "end_pos": 502 }, { "start_pos": 559, "end_pos": 561 }, { "start_pos": 605, "end_pos": 607 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A7E3C4-1", "uniprot_ac": "A7E3C4", "uniprot_id": "F187A_BOVIN", "mass": { "chemical_mass": 48434.0, "monoisotopic_mass": 48434.0 }, "refseq": { "ac": "XP_005221022", "name": "Ig-like V-type domain-containing protein FAM187A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221022" }, "gene_names": [ { "name": "FAM187A", "type": "recommended", "evidence": [ { "id": "A7E3C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3C4" } ] }, { "name": "FAM187A", "type": "synonym", "evidence": [ { "id": "XP_005221022", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221022" } ] } ], "protein_names": [ { "name": "Ig-like V-type domain-containing protein FAM187A", "type": "recommended", "evidence": [ { "id": "A7E3C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3C4/entry#names_and_taxonomy" } ] }, { "name": "Ig-like V-type domain-containing protein FAM187A", "type": "synonym", "evidence": [ { "id": "XP_005221022", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221022" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7E3C4", "url": "https://www.uniprot.org/uniprotkb/A7E3C4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM187A", "url": "https://www.uniprot.org/uniprotkb/A7E3C4", "locus": { "chromosome": "19", "start_pos": 44624544, "end_pos": 44608991, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013532", "url": "https://www.ensembl.org/id/ENSBTAG00000013532" } ] } } ], "crossref": [ { "id": "A7E3C4", "url": "https://alphafold.ebi.ac.uk/entry/A7E3C4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013532", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013532", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614821", "url": "https://www.ncbi.nlm.nih.gov/gene/614821", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039311", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039311", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614821", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614821", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AWDKDST", "url": "https://omabrowser.org/oma/group/AWDKDST/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A7E3C4", "url": "https://www.orthodb.org/?gene=A7E3C4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32178", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32178", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32178:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32178:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005221022", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221022", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A7E3C4", "url": "https://www.uniprot.org/uniprotkb/A7E3C4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7E3C4-1", "url": "https://www.uniprot.org/uniprotkb/A7E3C4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNLAHTTVLLWAWGSLQAFEIVEKENIFQRTPCPAFLMFDNAAYLTDMSFELPCPCKPEEVSAVVWYYQKHLGSSHTKVLTDFDGRVLTEAAQVRVGSDMLVRFSIRMFSLLVFRAQPEDSGLYFCGTRKGDYFYAYDVDIQSSEGMVATFKDQGQEPLEDEYHGSLRVFTTFWEWTPCDRCGVRGEQWRIGLCYLQSPDLSPRYRKILPNVVSCGSRAVPRQLRAKASDHNPELLVRSCLMPCEKKKKVQEGVMAIFNYVSKVGSRPWLPQVPIQFHQQRLGHGLIISCPGARPEHAVAWDKDHQYLYRTQYLKGVNGSMRVFIDHGNHLHIRFTQLEDRGIYYCWRQGERIAGFRLGVTSPGRYPVSFSDPETRAALGLILIGYMLITVIFISIHLCRCCCYLFRFCPNFSPRLSRPQL", "length": 421, "header": "sp|A7E3C4-1|F187A_BOVIN Isoform 1 of Ig-like V-type domain-containing protein FAM187A OS=Bos taurus OX=9913 GN=FAM187A PE=2 SV=2 CANONICAL=A7E3C4-1" }, "isoforms": [ { "isoform_ac": "A7E3C4-1", "url": "https://www.uniprot.org/uniprotkb/A7E3C4/entry#A7E3C4-1", "sequence": { "sequence": "MNLAHTTVLLWAWGSLQAFEIVEKENIFQRTPCPAFLMFDNAAYLTDMSFELPCPCKPEEVSAVVWYYQKHLGSSHTKVLTDFDGRVLTEAAQVRVGSDMLVRFSIRMFSLLVFRAQPEDSGLYFCGTRKGDYFYAYDVDIQSSEGMVATFKDQGQEPLEDEYHGSLRVFTTFWEWTPCDRCGVRGEQWRIGLCYLQSPDLSPRYRKILPNVVSCGSRAVPRQLRAKASDHNPELLVRSCLMPCEKKKKVQEGVMAIFNYVSKVGSRPWLPQVPIQFHQQRLGHGLIISCPGARPEHAVAWDKDHQYLYRTQYLKGVNGSMRVFIDHGNHLHIRFTQLEDRGIYYCWRQGERIAGFRLGVTSPGRYPVSFSDPETRAALGLILIGYMLITVIFISIHLCRCCCYLFRFCPNFSPRLSRPQL", "length": 421, "header": "sp|A7E3C4-1|F187A_BOVIN Isoform 1 of Ig-like V-type domain-containing protein FAM187A OS=Bos taurus OX=9913 GN=FAM187A PE=2 SV=2 CANONICAL=A7E3C4-1" }, "locus": { "chromosome": "19", "start_pos": 44624544, "end_pos": 44624359, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017992.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017992.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017992.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017992.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 318, "start_aa": "Asn", "end_pos": 318, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn318", "evidence": [ { "id": "A7E3C4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3C4#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:614821", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614821", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AB13-1", "protein_name": "Family with sequence similarity 187 member A", "gene_name": "FAM187A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEMGLLGAVLLLCMADVLHSFAIEEKEDIFRRMVCPAFLMFDNAAYLADMTFELPCNCKPEEVSNVVWYFQKNMGGHETTVLTDFSGNMVLDSGHIHVGSDVLKRFTIRMFSLIIFRAQVSDSGHYMCGTKKGDFFYGYDVDVQPTKHITVAFLDIGQHVQDDYTGKAFSLFTTFWDWTKCDRCGVRGEQRRIGLCYVQSARLHPRYRTVLPNVTSCGSRAVPARLQRSGRRWKPEVAVRSCMAPCPQENNPQEGVQAISNVIYKLGQKPWLPRVPTQFYRHPLGRDLVIACPGARPEHAVAWDKGSVRLYRSRYLVGVNKTMRVFIDHGNHLHIRRVRFSDRGTYFCWREGKLAAGLRLRVSYEAQRRRSLDDPETIYIIKAIGVSYVLVGAIFIGVHLCRCCSRVLRYSVRV", "length": 414 }, "evidence": [ { "id": "A7E3C4", "url": "https://omabrowser.org/oma/group/A7E3C4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7H366-1", "protein_name": "Ig-like V-type domain-containing protein FAM187A", "gene_name": "Fam187a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSLAHTTVLLWAWGSLQAFEIVEKENIFQKTPCPAFLMFDNAAYLADMSFELPCHCKPEDVSAVVWYYQKHLGSSHTTVLTDFDGRLLTEAAHVRAGSSMLVRFSIRMFSLLVFRAQPEDSGLYFCGTRKGDYFYAYDVDIQSSEGMVATFKDRGQEPLPDEYFGSLHVFTTFWEWTPCDRCGVHGEQWRLGLCYLQNPDLSPRYLKTLPDVVSCGSRAVPRKLWIRTRYHTPELLIQSCLVSCEKRNQIRKGMLTIYNYVSKMGSRPWLPQVPIQFHQQRLGHGLIISCPGARPEHAVAWDKDRQPLYRTQYLKGVNRSMRVFIDHGNHLHIRFTQLSDRGIYYCWRQGLRIAGFRLGVTSRGRYPASLSDPETRSAVELTLIGYLLITAIFVTIHVCRCCCYSFRCCPNFSTHALLQL", "length": 420 }, "evidence": [ { "id": "A7E3C4", "url": "https://omabrowser.org/oma/group/A7E3C4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1RR01-1", "protein_name": "Family with sequence similarity 187 member A", "gene_name": "FAM187A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNPAHTTVLLWVWGSLQAFEIVEKENIFQRTPCPAFLMFDNAAYLADMSFELPCHCKPEEVAAVVWYYQKHLGSSHTKVLTDFDGRVLTEAAQVRVGSDMLVRFSIRMFSLLVFRAQPEDSGLYFCGTRKGDYFYAYDVDIQSGEGMVATFKDQGQEPFADEYHGSLRVFTTFWEWTPCDRCGVRGEQWRIGLCYLQSPDLSPRYRRTLPDVVSCGSRAVPRPLRAKVSDHTPELLVRSCLVPCETTKIQKGVMAIFNYVSKVGSRPWLPQVPIQFHQQRLGHGLIISCPGARPEHAVAWDKDRQYLYRTQYLRGVNRSMRVFIDHGNHLHIRFTQLEDRGIYYCWRQGERIAGFRLGVTQRGRYPASFSDPETRAALRLTLIGYLLITAVFVTVHLCRCCCHLFRCWPDLSP", "length": 413 }, "evidence": [ { "id": "A7E3C4", "url": "https://omabrowser.org/oma/group/A7E3C4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6AXV7-1", "protein_name": "Ig-like V-type domain-containing protein FAM187A", "gene_name": "Fam187a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRLAPTTVLLWAWGSLQAFEIVEKENIFQRTPCPAFLVFDNTAYLADMSFELPCHCKPEDVSAVVWYYQKYLGSSHTTVLTDFDGRLLTEAAHVRVGSSMLARFSIRMFSLLVFRAQPEDSGLYFCGTRNGDYFYAYDVDIQSHKGMVASFRDKGQEPLPDEYYGSLHVFTTFWEWTPCDRCGVRGEQWRFGLCYLQNPNLSPRYIKTLPDVVSCGSRAVPWKLHLKTKYHTPELLIQSCLVSCKKNKMGEGILAIYNYVSKLGGRPWVPQVPIQFHQQRLGHGLIISCPGARPEHAVAWDKDSQPLYRTQYLKGVNRSMRVFIDHGNHLHIRFTQLSDRGIYYCWRQGLKIAGFRLGVTSRGRYPASLSDPETRTAVELTLIGYLLIAVVFVTIHLCRCCCQSRCCPNFSAQTLLQL", "length": 418 }, "evidence": [ { "id": "A7E3C4", "url": "https://omabrowser.org/oma/group/A7E3C4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D3R5-1", "protein_name": "Ig-like V-type domain-containing protein FAM187A", "gene_name": "Fam187a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLAHTTVLLWAWGSLQAFEIVEKESVFQRTPCPAFLVFDNAAYLADMSFELPCHCKPEDVSAVVWYYQKHLGSKRTTVLTDFDGRLLTEAAHVRVGSSMLVRFSIRMFSLLVFRAQPEDTGLYFCGTREGDYFYAYDVDIQSNKEIVASFKDMAQEPLPDEYYGALHVFTTFWEWTPCDRCGVRGEQWRFGLCYLQYPDLSPRYIKTRSAVVSCGSGAVPWKLHLQTKYHTPELQFQSCLVSCQKRNKTRKGVLAIYSYVSKLGSRPWVPQVPIQFHQQRLGHGLIISCPGARPEHAVAWDKDNQPLYRAQYLKGVNRSMRVFIDHGNHLHIRFTQLSDRGIYYCWLQGLKIAGFRLGVITRGRYPASLSDPETRTAIELTLMGYLLITIFFITIHLCRCCCQSRCCPNFSAQTLL", "length": 417 }, "evidence": [ { "id": "A7E3C4", "url": "https://omabrowser.org/oma/group/A7E3C4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A7E3C4", "url": "https://www.uniprot.org/uniprotkb/A7E3C4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" }, { "start_pos": 411, "end_pos": 413, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7E3C4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 421, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7E3C4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7E3C4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 318 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 318, "end_pos": 320 }, { "start_pos": 411, "end_pos": 413 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A7E3D8-1", "uniprot_ac": "A7E3D8", "uniprot_id": "LCA5L_BOVIN", "mass": { "chemical_mass": 76371.0, "monoisotopic_mass": 76371.0 }, "refseq": { "ac": "NP_001181997", "name": "lebercilin-like protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181997" }, "gene_names": [ { "name": "LCA5L", "type": "recommended", "evidence": [ { "id": "A7E3D8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3D8" } ] }, { "name": "LCA5L", "type": "synonym", "evidence": [ { "id": "NP_001181997", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181997" } ] } ], "protein_names": [ { "name": "Lebercilin-like protein", "type": "recommended", "evidence": [ { "id": "A7E3D8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3D8/entry#names_and_taxonomy" } ] }, { "name": "LCA5L, lebercilin like", "type": "synonym", "evidence": [ { "id": "NP_001181997", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181997" } ] }, { "name": "Leber congenital amaurosis 5-like protein", "type": "synonym", "evidence": [ { "id": "NP_001181997", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181997" }, { "id": "A7E3D8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3D8/entry#names_and_taxonomy" } ] }, { "name": "lebercilin-like protein", "type": "synonym", "evidence": [ { "id": "NP_001181997", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181997" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7E3D8", "url": "https://www.uniprot.org/uniprotkb/A7E3D8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LCA5L", "url": "https://www.uniprot.org/uniprotkb/A7E3D8", "locus": { "chromosome": "1", "start_pos": 139470703, "end_pos": 139512432, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030993", "url": "https://www.ensembl.org/id/ENSBTAG00000030993" } ] } } ], "crossref": [ { "id": "A7E3D8", "url": "https://alphafold.ebi.ac.uk/entry/A7E3D8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030993", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030993", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "781766", "url": "https://www.ncbi.nlm.nih.gov/gene/781766", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028933", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028933", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:781766", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781766", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MKHQETQ", "url": "https://omabrowser.org/oma/group/MKHQETQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A7E3D8", "url": "https://www.orthodb.org/?gene=A7E3D8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16650", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16650", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16650:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16650:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15619", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15619", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001181997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181997", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A7E3D8", "url": "https://www.uniprot.org/uniprotkb/A7E3D8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7E3D8-1", "url": "https://www.uniprot.org/uniprotkb/A7E3D8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLAGPTETNLGGHFPGTAVENGGSSSKRESSSPGFPRNSNASDKSVDYSRSRCSCRSPSSHYDYSEDFLSACSETTARNNYLEKPTVKEKKEKKKYNVSKISQLKGQKEISVRKKHSWNVPFLNSQISVAAQRRDAMIHRILSARLHKIKELKNELADLHHKAEATVIENQFLKQVQLKHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQGKERATSRKLREMDGELLRTKDALQALQKISEENNLPEREELTQRLSILTAKMEANDKKIQDLEKQLRLNNKAFTRQLTFENRKTLAAQAATKTLQMEIKHLQQKLKEKDRELEIRNIYSNRIVGNLHDKEDYPKVSSTKSVQADRRSFPFISMRHQETQKSEDVASWTTKSKKTTGNNGHKEKSIEIIHAMPPCITKLPNQEDSKRKYEDLSKEEQHLEAQPSLKNTGQQRYRTENQEKKITLVKEEQELPPKRIEVIHPEGEGGQEDDTEKYKFKRSPEISDMGDMPDKNAAPHIKIPFRQRKHYSFTEAIENLHHGLPASGGLANAGSTRYPHSTGKHHSHSEEMKLEHPAIAYEPSFAKSYRTKAKDTTFREKKSNLMEELFGSDYVLKNNQTSTTVMKEPEETLQSTKIHHLPPSQASASNAFGDSGVTVVNSIKSSSPTEGNRKIII", "length": 670, "header": "sp|A7E3D8-1|LCA5L_BOVIN Isoform 1 of Lebercilin-like protein OS=Bos taurus OX=9913 GN=LCA5L PE=2 SV=2 CANONICAL=A7E3D8-1" }, "isoforms": [ { "isoform_ac": "A7E3D8-1", "url": "https://www.uniprot.org/uniprotkb/A7E3D8/entry#A7E3D8-1", "sequence": { "sequence": "MSLAGPTETNLGGHFPGTAVENGGSSSKRESSSPGFPRNSNASDKSVDYSRSRCSCRSPSSHYDYSEDFLSACSETTARNNYLEKPTVKEKKEKKKYNVSKISQLKGQKEISVRKKHSWNVPFLNSQISVAAQRRDAMIHRILSARLHKIKELKNELADLHHKAEATVIENQFLKQVQLKHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQGKERATSRKLREMDGELLRTKDALQALQKISEENNLPEREELTQRLSILTAKMEANDKKIQDLEKQLRLNNKAFTRQLTFENRKTLAAQAATKTLQMEIKHLQQKLKEKDRELEIRNIYSNRIVGNLHDKEDYPKVSSTKSVQADRRSFPFISMRHQETQKSEDVASWTTKSKKTTGNNGHKEKSIEIIHAMPPCITKLPNQEDSKRKYEDLSKEEQHLEAQPSLKNTGQQRYRTENQEKKITLVKEEQELPPKRIEVIHPEGEGGQEDDTEKYKFKRSPEISDMGDMPDKNAAPHIKIPFRQRKHYSFTEAIENLHHGLPASGGLANAGSTRYPHSTGKHHSHSEEMKLEHPAIAYEPSFAKSYRTKAKDTTFREKKSNLMEELFGSDYVLKNNQTSTTVMKEPEETLQSTKIHHLPPSQASASNAFGDSGVTVVNSIKSSSPTEGNRKIII", "length": 670, "header": "sp|A7E3D8-1|LCA5L_BOVIN Isoform 1 of Lebercilin-like protein OS=Bos taurus OX=9913 GN=LCA5L PE=2 SV=2 CANONICAL=A7E3D8-1" }, "locus": { "chromosome": "1", "start_pos": 139496147, "end_pos": 139470706, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064834.2", "url": "https://www.ensembl.org/id/ENSBTAT00000064834.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054161.1", "url": "https://www.ensembl.org/id/ENSBTAP00000054161.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:781766", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781766", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AG60-1", "protein_name": "Lebercilin-like protein", "gene_name": "Lca5l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRLWTMSLADTTEAHTNEHFPSLALGSNRKSAEGKHSPGAGGLSRNSRASSGSVDYSRSRCSCTSLTSRYDYSEDFLSECSETAVSRHQPEQLLGKEKEKRKYNTCKFPQPKGQKDIPAEKRHIWNASFFSSQIQTIAKRRDTMTHRILSARLHKIKELKNELADIHRKLEATILENQFLKQLQLRHLKAIGTYVNSQNNLPQITVKHQNEVKNLRQLLRKSQEKERAVSRKLRETDSELLRTKDALQALQRLSEDKNLAEREELTHRLTDLTAKMEANDKKIQNLEKQLRLNNRSFSRQLAKENRKTLAAQTATKALQAEVRQLQQKLKEKDRELEIKNIYTNRILKNLHDKEDYPKVSSTKSVQADRKSLPFVNVRHQETQKSDVPFWITKDKKAKGNIVHKEKSTEINHDISYHVRKLPRQEESKRKCEANLTVLKNMPSPRVSWEQVATEQICAFHLECHSCTQTDLSKEVEHPKPQTSLETPRRPKERKEDQEKRAIPEEAEPTAKGSEVPEDAEDKALARAACDVGDAGDAGDAGDADHASDAGDVRDVVEDSEVIGAHELPGANQAGEVHGASEAGDVEPGRGRRKTPRSRKHYSFTEATENLHHGLPTSCRQASGSPHCRCRHCTGKHRSEQELRLEPAGYEPSFGKAARTRARATAFRDRKSSLMEELFGSGFAGRAGPNDGEAPSKSPQPGPQASAGNAFGDSKATVARSIQASPPEANRKTAV", "length": 734 }, "evidence": [ { "id": "A7E3D8", "url": "https://omabrowser.org/oma/group/A7E3D8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0YEA2-1", "protein_name": "Lebercilin-like protein", "gene_name": "LCA5L", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGLRLRLPGCSAAAVRPRGNGGAQRLCRKIGSPSKYVTQTIPQSTEELEAAAEAEVMTEGNAVENAEVKIIKLTILRALSVTCSETARSSRCLELSGTEEKKMQKNERKRKKKKEQQIFSQNNKGGKKLPAKKIPHEKSSFLSLQNNTISQKKNKVAQRILSARLHKIKELKNEISDLQHKLEASNLENQVLKRLLYRHSKAIGGYESSESVLPDLLTRHYSEVSALRKHLRISQEEERRASRKLRKVEAELLKAKDDLQALYKLSEDKTLAERDELYHRLSVLTEKMEVNNKRIQSLEKQLKLNNSTFSRQLANENKKAVEAGIITKNLQMEINSLHQKIKEKDRQLYIKNIYTNRLLKIPKDKGDAVSHKKSLSINTSLQADKQHFRSLQLPQYQPQETEESLVLLHEEKKASEGKNQKAKASEAYTDAQCETEKQSSKKIPKPETFSRTHKEYLKENKPLTVHTCLEFISQEERKRDLLKQKPEKAEETLLNDSVKENNQEEDAVEEKEKKSEEQLSKSGKAGSDFLTPRNRTLSKLKKQYVFSETTENLHQGLPTSGAKSTKGNLCNQRHASQDQCKEAESKVKKLFGLYEQPFSKVTKTRQKDSSTEAEGCAHTIFSERKKSLMKELFGEGGVCKDNHSCSNRRGMERKL", "length": 656 }, "evidence": [ { "id": "A7E3D8", "url": "https://omabrowser.org/oma/group/A7E3D8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O95447-1", "protein_name": "Lebercilin-like protein", "gene_name": "LCA5L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLADLTKTNIDEHFFGVALENNRRSAACKRSPGTGDFSRNSNASNKSVDYSRSQCSCGSLSSQYDYSEDFLCDCSEKAINRNYLKQPVVKEKEKKKYNVSKISQSKGQKEISVEKKHTWNASLFNSQIHMIAQRRDAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNLPQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAEREELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVEVKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQGTQKSDVPPLTTKGKKATGNIDHKEKSTEINHEIPHCVNKLPKQEDSKRKYEDLSGEEKHLEVQILLENTGRQKDKKEDQEKKNIFVKEEQELPPKIIEVIHPERESNQEDVLVREKFKRSMQRNGVDDTLGKGTAPYTKGPLRQRRHYSFTEATENLHHGLPASGGPANAGNMRYSHSTGKHLSNREEMELEHSDSGYEPSFGKSSRIKVKDTTFRDKKSSLMEELFGSGYVLKTDQSSPGVAKGSEEPLQSKESHPLPPSQASTSHAFGDSKVTVVNSIKPSSPTEGKRKIII", "length": 670 }, "evidence": [ { "id": "A7E3D8", "url": "https://omabrowser.org/oma/group/A7E3D8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C0X0-2", "protein_name": "Lebercilin-like protein", "gene_name": "Lca5l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRLWTMSLADTTEAHTNEHFPSLALGSNKKSTEGKRSPGAGGQSQNSQASNGSVDYSRSQCSCTSLTSHYDYSEDFLSDCSETAVRRLQSEKPLAKAKEKRKYNAGKLPQPRGQKDIPAEKKQFWNASLISSQIQTIAKRRDTMTHRILSARLHKIKELKNELADVHRKLEASAIENQFLKQLQLRHLKAIGKYVNSQNNLPQITAKHQNEVKNLRQLLRKSQEKERAVSRKLRETDGELLRTKDVLQALQRLSEDKNLAEREELTDRLTDLTAKMEANDKKIQNLEKQLRLNNRSYSRQLAKENRKTLAAQTATKTLQAEVRQLQQKLKEKDRELEIKNIYTNRILKNLNDKEDYPKVSSTKSVQADRKSLPSVNMRHQETQKSDVPFWITKGKRGKGNIAHKEKSTETNHDIPYYVCKLPKQEESKRKYEANLTVLKSMPSPPASWGLVATEQICAFHLECHSCTHTADLSKEVEHRKPQTSLETPRRPKENKEDQEKRAIPAEAEPTAKESEAHKDAEDKALTRAAGNAGDAGDAGDAGNDREVVGEHKVVGAQEVVGAQELPGADEADEVHGAGEAPRDVEPGRGRRKTPRKHYSFTEATENLHHGLPTSCRQVSGSPHCRCRHDMGKHRSEQELRLEPAGYEPSFGKGAGARARARARATAFRDRKSSLMEELFGAGFAGRAGSSDSEAVSKSPQTGPQASAGNAFGDSRATVAGSIQASPTEANRKTVV", "length": 735 }, "evidence": [ { "id": "A7E3D8", "url": "https://omabrowser.org/oma/group/A7E3D8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "A7E3D8", "url": "https://www.uniprot.org/uniprotkb/A7E3D8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "intraciliary transport", "id": "GO:0042073", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042073", "evidence": [ { "database": "UniProtKB", "id": "A7E3D8", "url": "https://www.uniprot.org/uniprotkb/A7E3D8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 41, "end_pos": 43, "annotation": "n_glycosylation_sequon" }, { "start_pos": 612, "end_pos": 614, "annotation": "n_glycosylation_sequon" }, { "start_pos": 98, "end_pos": 100, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7E3D8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 670, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7E3D8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7E3D8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 41, "end_pos": 43 }, { "start_pos": 612, "end_pos": 614 }, { "start_pos": 98, "end_pos": 100 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A7MB05-1", "uniprot_ac": "A7MB05", "uniprot_id": "TM215_BOVIN", "mass": { "chemical_mass": 25841.0, "monoisotopic_mass": 25841.0 }, "refseq": { "ac": "NP_001094541", "name": "transmembrane protein 215", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094541" }, "gene_names": [ { "name": "TMEM215", "type": "recommended", "evidence": [ { "id": "A7MB05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB05" } ] }, { "name": "TMEM215", "type": "synonym", "evidence": [ { "id": "NP_001094541", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094541" } ] } ], "protein_names": [ { "name": "Transmembrane protein 215", "type": "recommended", "evidence": [ { "id": "A7MB05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB05/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 215", "type": "synonym", "evidence": [ { "id": "NP_001094541", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094541" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7MB05", "url": "https://www.uniprot.org/uniprotkb/A7MB05" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM215", "url": "https://www.uniprot.org/uniprotkb/A7MB05", "locus": { "chromosome": "8", "start_pos": 11330165, "end_pos": 11335552, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013974", "url": "https://www.ensembl.org/id/ENSBTAG00000013974" } ] } } ], "crossref": [ { "id": "A7MB05", "url": "https://alphafold.ebi.ac.uk/entry/A7MB05", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013974", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013974", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510133", "url": "https://www.ncbi.nlm.nih.gov/gene/510133", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031486", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031486", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510133", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510133", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DRSDCPE", "url": "https://omabrowser.org/oma/group/DRSDCPE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A7MB05", "url": "https://www.orthodb.org/?gene=A7MB05", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31922", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31922", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31922:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31922:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15746", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15746", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001094541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094541", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A7MB05", "url": "https://www.uniprot.org/uniprotkb/A7MB05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7MB05-1", "url": "https://www.uniprot.org/uniprotkb/A7MB05-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPDDINPRTGLVVALVSVFLVFGFMFTVSGMKGETLGNIPLLAIGPAICLPGIAAIALARKTEGCTKWPENELLWVRKLPCFRKPKDKEVVELLRTPSDLESGKGSSDELAKKAGLRGKPSLQGQGELPMASSITTPTPMEEGECQSPGQSGRREETSRYLDGYCPSGSSLTYSALDAKCSAWDRSEHPEPEDSIFFVPQDSIIVCSYKQNSPYDRYCCYINQSQGRWDHETIV", "length": 235, "header": "sp|A7MB05-1|TM215_BOVIN Isoform 1 of Transmembrane protein 215 OS=Bos taurus OX=9913 GN=TMEM215 PE=2 SV=1 CANONICAL=A7MB05-1" }, "isoforms": [ { "isoform_ac": "A7MB05-1", "url": "https://www.uniprot.org/uniprotkb/A7MB05/entry#A7MB05-1", "sequence": { "sequence": "MRPDDINPRTGLVVALVSVFLVFGFMFTVSGMKGETLGNIPLLAIGPAICLPGIAAIALARKTEGCTKWPENELLWVRKLPCFRKPKDKEVVELLRTPSDLESGKGSSDELAKKAGLRGKPSLQGQGELPMASSITTPTPMEEGECQSPGQSGRREETSRYLDGYCPSGSSLTYSALDAKCSAWDRSEHPEPEDSIFFVPQDSIIVCSYKQNSPYDRYCCYINQSQGRWDHETIV", "length": 235, "header": "sp|A7MB05-1|TM215_BOVIN Isoform 1 of Transmembrane protein 215 OS=Bos taurus OX=9913 GN=TMEM215 PE=2 SV=1 CANONICAL=A7MB05-1" }, "locus": { "chromosome": "8", "start_pos": 11335139, "end_pos": 11334435, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018581.3", "url": "https://www.ensembl.org/id/ENSBTAT00000018581.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018581.2", "url": "https://www.ensembl.org/id/ENSBTAP00000018581.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510133", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510133", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XMM5-1", "protein_name": "Transmembrane protein 215", "gene_name": "TMEM215", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MARTMRPDDINPRTGLVVALVSVFLVFGFMFTVSGIKGETLGDIPLLAIGPAICLPGIAAIALTRKTDGCTKWPKNKCPCCKEIRDRDVMELLRTPSDLESGKGSCDELAKKVYQKDRRVLRGEDSVSICTTTTTTTTGECKSLIRKVDQEEMLRYLETCYPEMPGNVFVGDGSPYSALEKKSSSPSRDIAACPDVEDNIFVAPKDSIIVCSYKENSPYEKYCCYINPTGVASDQETIV", "length": 239 }, "evidence": [ { "id": "A7MB05", "url": "https://omabrowser.org/oma/group/A7MB05/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A7E1Z1-1", "protein_name": "Transmembrane protein 215", "gene_name": "Tmem215", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRPDDINPRTGLVVALVSVFLVFGFMFTVSGMKGETLGNIPLLAIGPAICLPGIAAIALARKTEGCTKWPENELLWVRKLPCFRKPKDKEVVELLRTPSDLESGKGSSDELAKKAGLRGKQLPQGPGEVPMASSVTTPTPTEEGECQSLVQSGRQEETSRYLDGYCPSASSLAYSALDAKCSAWDRSDRPEPEDSIFFVPQDSIIVCSYKQNSPYDRYCCYINQSQGRWDHETIV", "length": 235 }, "evidence": [ { "id": "A7MB05", "url": "https://omabrowser.org/oma/group/A7MB05/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZI94-1", "protein_name": "Transmembrane protein 215", "gene_name": "Tmem215", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRPDDINPRTGLVVALVSVFLVFGFMFTVSGMKGETLGNIPLLAIGPAICLPGIAAIALARKTEGCTKWPENELLWVRKLPCFRKPKDKEVVELLRTPSDLESGKGSSDELAKKAGLRGKQLPQGPGEVPMASSITTPTPTEEGECQSLVQSGRQEETSRYLDGYCPSASSLAYSALDAKCSGWDRSDRPEPEDSIFFVPQDSIIVCSYKQNSPYDRYCCYINQSQGRWDHETIV", "length": 235 }, "evidence": [ { "id": "A7MB05", "url": "https://omabrowser.org/oma/group/A7MB05/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SE71-1", "protein_name": "Transmembrane protein 215", "gene_name": "TMEM215", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRPDDINPRTGLVVALVSVFLVFGFMFTVSGMKGETLGNIPLLAIGPAICLPGIAAIALARKTEGCTKWPENELLWVRKLPCFRKPKDKEVVELLRTPSDLESGKGSSDELAKKAGLRGKPPLQGQGEVPGASSITTPTPMKEGECQSPVQSRHREETSRYLDGYCPSGSSITYSALDVKCSAWDKSECPEPEDSIFFVPQDSIIVCSYKQNSPYDRYCCYINQSQGRWDHETIV", "length": 235 }, "evidence": [ { "id": "A7MB05", "url": "https://omabrowser.org/oma/group/A7MB05/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q68D42-1", "protein_name": "Transmembrane protein 215", "gene_name": "TMEM215", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRPDDINPRTGLVVALVSVFLVFGFMFTVSGMKGETLGNIPLLAIGPAICLPGIAAIALARKTEGCTKWPENELLWVRKLPCFRKPKDKEVVELLRTPSDLESGKGSSDELAKKAGLRGKPPPQSQGEVSVASSINSPTPTEEGECQSLVQNGHQEETSRYLDGYCPSGSSLTYSALDVKCSARDRSECPEPEDSIFFVPQDSIIVCSYKQNSPYDRYCCYINQIQGRWDHETIV", "length": 235 }, "evidence": [ { "id": "A7MB05", "url": "https://omabrowser.org/oma/group/A7MB05/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A7MB05", "url": "https://www.uniprot.org/uniprotkb/A7MB05" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 223, "end_pos": 225, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7MB05-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 235, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7MB05-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7MB05" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 223, "end_pos": 225 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A7MB27-1", "uniprot_ac": "A7MB27", "uniprot_id": "RHG36_BOVIN", "mass": { "chemical_mass": 59709.0, "monoisotopic_mass": 59709.0 }, "refseq": { "ac": "NP_001095458", "name": "rho GTPase-activating protein 36 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095458" }, "gene_names": [ { "name": "ARHGAP36", "type": "recommended", "evidence": [ { "id": "A7MB27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB27" } ] }, { "name": "ARHGAP36", "type": "synonym", "evidence": [ { "id": "NP_001095458", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095458" } ] } ], "protein_names": [ { "name": "Rho GTPase-activating protein 36", "type": "recommended", "evidence": [ { "id": "A7MB27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB27/entry#names_and_taxonomy" } ] }, { "name": "rho GTPase-activating protein 36 precursor", "type": "synonym", "evidence": [ { "id": "NP_001095458", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095458" } ] }, { "name": "rho GTPase-activating protein 36", "type": "synonym", "evidence": [ { "id": "NP_001095458", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095458" } ] } ], "function": [ { "annotation": "GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.", "evidence": [ { "database": "UniProtKB", "id": "A7MB27", "url": "https://www.uniprot.org/uniprotkb/A7MB27#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7MB27", "url": "https://www.uniprot.org/uniprotkb/A7MB27" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARHGAP36", "url": "https://www.uniprot.org/uniprotkb/A7MB27", "locus": { "chromosome": "X", "start_pos": 15112740, "end_pos": 15081369, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021189", "url": "https://www.ensembl.org/id/ENSBTAG00000021189" } ] } } ], "crossref": [ { "id": "A7MB27", "url": "https://alphafold.ebi.ac.uk/entry/A7MB27", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021189", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021189", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04376", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04376", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514137", "url": "https://www.ncbi.nlm.nih.gov/gene/514137", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041852", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041852", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514137", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514137", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NTFEKWF", "url": "https://omabrowser.org/oma/group/NTFEKWF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A7MB27", "url": "https://www.orthodb.org/?gene=A7MB27", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12635", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12635", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12635:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12635:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00620", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00620", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095458", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A7MB27", "url": "https://www.uniprot.org/uniprotkb/A7MB27", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7MB27-1", "url": "https://www.uniprot.org/uniprotkb/A7MB27-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPPLLLLSALIFLVNVLGGAPGHNPNRRAKMISIHSLSELERLKLQEAAYHELVARQFLSEFKPERALPTDRSNTFEKWFLILRGQERAVSLKTFGIRLEEVLVNELTRRKQVELRATMQMQEAAGPATSGRRRGNAVQRMFGRIRRIFSGRRDEPFLPREFTRRGRRGAVSADSLAELEGGALLLQTLQLSRISFPIGQRLLGSKRKMSLNPIAKQIPHVVEACCSFIEKHGLSTVGIFTLEYSEKRVRKLREEFDQGLDVVLDDSQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLQTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKVLHKVAENCEDSIGIDGQLVSGNRMTSTNLALVFGSALLKKGASAKRESRKTRLGIDHYVASVSVVRAMIDNWDVLFQVPPHIQKQVAKRVWKSSPEALDFIRRRNLRKIQSERIKMEEDALLSDPVETSAEARAAILGQSKPFDEGSSEEPAVPPGTARSHDDEEGAGNPLILEQDRPLLRVPREKEAKTGIGYFFP", "length": 530, "header": "sp|A7MB27-1|RHG36_BOVIN Isoform 1 of Rho GTPase-activating protein 36 OS=Bos taurus OX=9913 GN=ARHGAP36 PE=2 SV=1 CANONICAL=A7MB27-1" }, "isoforms": [ { "isoform_ac": "A7MB27-1", "url": "https://www.uniprot.org/uniprotkb/A7MB27/entry#A7MB27-1", "sequence": { "sequence": "MPPLLLLSALIFLVNVLGGAPGHNPNRRAKMISIHSLSELERLKLQEAAYHELVARQFLSEFKPERALPTDRSNTFEKWFLILRGQERAVSLKTFGIRLEEVLVNELTRRKQVELRATMQMQEAAGPATSGRRRGNAVQRMFGRIRRIFSGRRDEPFLPREFTRRGRRGAVSADSLAELEGGALLLQTLQLSRISFPIGQRLLGSKRKMSLNPIAKQIPHVVEACCSFIEKHGLSTVGIFTLEYSEKRVRKLREEFDQGLDVVLDDSQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLQTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKVLHKVAENCEDSIGIDGQLVSGNRMTSTNLALVFGSALLKKGASAKRESRKTRLGIDHYVASVSVVRAMIDNWDVLFQVPPHIQKQVAKRVWKSSPEALDFIRRRNLRKIQSERIKMEEDALLSDPVETSAEARAAILGQSKPFDEGSSEEPAVPPGTARSHDDEEGAGNPLILEQDRPLLRVPREKEAKTGIGYFFP", "length": 530, "header": "sp|A7MB27-1|RHG36_BOVIN Isoform 1 of Rho GTPase-activating protein 36 OS=Bos taurus OX=9913 GN=ARHGAP36 PE=2 SV=1 CANONICAL=A7MB27-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514137", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514137", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1W2Q6M1-1", "protein_name": "Rho GTPase activating protein 36", "gene_name": "Arhgap36", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRPCPLSDKLEVSGDQDSQCWVQGAAQGVVTGGYLEQSLRGDCTEEVSCEAAGHSARVMAWMLDCLFASAFEPRPRRVCVLGGAPGQNPDRSRMDMVSIHSLSELERLKLQETAYHELVARHFLSEFKPDRVQPTDRPNTLQKWFQMLRGQDRAASLKTFGIRLEEVLVNELTRRKQRELTDNMQVEDINGSTGRRRRGNVVQRMFGRMRRFFSRRRNEPTLPREFTRRGRRGAISVDSVAELENGALLLQILQLSQLSLPIGQRLLGSKRKMSLNPIAQQIPHIVETCCKFIEKHGLSSVGIFTIEYSLRRVIELRELFDKGMDIVLDDSVNVNDVAELLKEFFREMKDSLLPDELYMSFLLTATLKPQDQVSALQLLVYLMPPCHSDTLERLLKALHKVTENCEDSIGLDGQLVPGNRMTSTNLALVFGTSLLKKGKLAKRESRKTKLGIDHYVASVNVVRAMIDNWDILFQVPPHIQKQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVDNSAEAQAAILAQSQPFDEDPEGAPDVNFGDGMNYDFEDDSDFEDEDHPDLAEVPYLDVIPNNEDTDSDADEMPGSSEEPAVPAGTARSRDKDEGAGNPPNAERPLPRVPREKEGKSGTGFFP", "length": 646 }, "evidence": [ { "id": "A7MB27", "url": "https://omabrowser.org/oma/group/A7MB27/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A5G2QJG9-1", "protein_name": "Rho GTPase-activating protein 36", "gene_name": "ARHGAP36", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MISIHSLSELERLKLQETAYHELVARHFLSEFNPERALPTDRPNTLEKWFLILRGQERAVSLKTFGIRLEEVLVNELTRRKQLELRAAMQVEEATTGRAGGRRRRRGNVVQRVFGRIRRFFSRRRDEPSLPREFTRRGRRGAVSVDSLAELEDGALLLQTLQLSKISLPIGQRLLGSKRKMSLNPIAKQIPQVVEACCSFIEKYGLSTVGIFTLEYSEERVRKLREEFDQGLDVVLDDTRNVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVLGNRMTSTNLALVFGSALLKRGQSAKRESRKTRLGIDHYVASVNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRRIQSARIKMEEDALLSDPVENSAEVRAAVLAQSKPFDEGQFPAGGQTLAEGQALAEGQALGEGQALPEGQVFAEDEPLEEDESSEEDVSVNEELVFEYLNQGIVFGEVQGLEIPNDLEIQGPHLEGIPELDEEEEEEEDDDDDDTLNFDDLPPLEDILDPDDEIPELIEIPDFEEIPYFDMVPEPEGVLYVQEIPNPGENPNHDLEEGPDFEDYQNLNLAEVPYLDVILNNEEAPVTDEIPDHADDSDDDENPDSGEDPNLEEVPALAEIPNDEASTAEEVPDHEEALEVSGISDSDEDLDFDEVPALHVVPSPEEAPGGHEVPNHEESLEVNGLSDSEEDPNLEEVPALDGVPNDEEISDTEEIPDYEETPEDNEIPGSEAESSPEEVPALHVVTSPEDVSNLDEIQNQEESSDVSGVSHHEEASEAEEIPGHREASDVSGVQDAEENPSLEEDSVEDEVTSVAPEPEDVSLLNTIPDPQPDLAVHLEEIMNVEAVPMPNSLDSKGAQNPKATQLSKKDADVTFLVDTTFLKNKSQPGQVMDSRSSSESVKTNTCFLPSMKCCKLPAPALFLMCLVKAVRLVVGWWWLLGGRPLPRFPGGVAHLV", "length": 1018 }, "evidence": [ { "id": "A7MB27", "url": "https://omabrowser.org/oma/group/A7MB27/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0AB32TYH8-1", "protein_name": "Rho GTPase-activating protein 36 isoform X1", "gene_name": "arhgap36", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVLFYMGSDKTSSVVMQPEDPVRQDMQFYYVGDHTWATMLGQSVRLQPVAIQSLSELERARLQEVALYHLERRDLDFKISIPREIRKRRKSLRRKFDSFSKEKKDRESAPKAFSIPLSQVIANDLAYKQRQDALKESRRDCLDLEASVLHFRAEKWQQNGNRPLGKTVLSPGAASSPVLELHSKPPSSAFMDNTSRTHRRGGMSVDSISDMVESQSRLLEALQLSHPNELEMKKAAGRTQAKLSLNPIYRQVPRVVERCCNHIQTYGLQTLGIFRVGSSKKRVRQLREDFDNGIDVVLDEEHSVHDVAALLKEFLRDMPDPLLPRELYRAFLHANLLRGADQLSYLQQLLYLLPPCNCDTLLRLLTLLHTVQENANSSTGPNKQEISGNKMTAANLAVIFGPNLLQKERGSERELSPQALGIEDSTAVISVTLMLIQNHQHLFMVSAELQQEVLMSLIQTDPDVIDYLLRRKLSSSSSLTVEPDSGGRRDTQSSLDSMGQSSDDLSSREPLCPLYPEHSAIGSLSSEVLLNVLHLNTNRKRSSEVPPKSIVKMRQFHSHHNLLSLTQSSSNAPSDERELQEQRQASSRHTCPEERLHFTLSRKDSGSQPQSPREKGIWVRQNSNASSTTSDDSKTPSNFWDFFTGKVSGSETIIPVVRRSPSLQNFFNDHSQSEKR", "length": 676 }, "evidence": [ { "id": "A7MB27", "url": "https://omabrowser.org/oma/group/A7MB27/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "B1AUC7-1", "protein_name": "Rho GTPase-activating protein 36", "gene_name": "Arhgap36", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAWMLDCLFASAFEPRPRRVSVLGGAPGQNSDRSMDMVSIHSLSELERLKLQETAYHELVARHFLSEFKPDRALPTDRPNTLEKWFLMLRGQDRAASLKTFGIRLEEVLVNELTRRKQRELTPTMQVEDINGSTGRRRRGNVVQRMLGRMRRFFSRRRNEPTLPREFTRRGRRGAVSADSADELENGALLLQILQLSQLSSPIGQRLLGSKRKMSLNPIAQQIPQIVETCCKFIEKHGLSSVGIFTIEYSLRRVLELRELFDKGLDIVLDDSVNVHDVAELLKEFFREMKDPLLPDDLYMSFLLTATLKPKDQVSALQLLVYLMPPCHSDTLERLLKALHKITENCEDSIGVDGQLVPGNRMTSTNLALVFGTALLKKGKLANKESRKTKLGIDHYVASVNVVRAMIDNWDILFQVPPHIQKEVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVENSAEAQAAILAQSQPFDEDPEGAPDVHEVLNDNLNYDFEDESDFEDQDHLDLAEVPYLDVIPNNEDTDSDADVIPGPSEEPAVPASTAGSPDKEEGAAGNPPNADRPLPRVPQGKKGKFATRFFP", "length": 590 }, "evidence": [ { "id": "A7MB27", "url": "https://omabrowser.org/oma/group/A7MB27/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6ZRI8-1", "protein_name": "Rho GTPase-activating protein 36", "gene_name": "ARHGAP36", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGGCIPFLKAARALCPRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELERLKLQETAYHELVARHFLSEFKPDRALPIDRPNTLDKWFLILRGQQRAVSHKTFGISLEEVLVNEFTRRKHLELTATMQVEEATGQAAGRRRGNVVRRVFGRIRRFFSRRRNEPTLPREFTRRGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSAEARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQDRPLLRVPREKEAKTGVSYFFP", "length": 547 }, "evidence": [ { "id": "A7MB27", "url": "https://omabrowser.org/oma/group/A7MB27/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A7MB27", "url": "https://www.uniprot.org/uniprotkb/A7MB27" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "A7MB27", "url": "https://www.uniprot.org/uniprotkb/A7MB27" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A7MB27", "url": "https://www.uniprot.org/uniprotkb/A7MB27" } ], "pmid": "" }, { "name": "positive regulation of intracellular signal transduction", "id": "GO:1902533", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902533", "evidence": [ { "database": "UniProtKB", "id": "A7MB27", "url": "https://www.uniprot.org/uniprotkb/A7MB27" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "A7MB27", "url": "https://www.uniprot.org/uniprotkb/A7MB27" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7MB27-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 530, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7MB27-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7MB27" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A7MB27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB27" }, { "id": "PRU00172", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00172" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rho-GAP", "eco_id": "ECO_0000255", "start_pos": 209, "end_pos": 409, "start_aa": "Met", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A7MB54-1", "uniprot_ac": "A7MB54", "uniprot_id": "HLX_BOVIN", "mass": { "chemical_mass": 50415.0, "monoisotopic_mass": 50415.0 }, "refseq": { "ac": "NP_001094567", "name": "H2.0-like homeobox protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094567" }, "gene_names": [ { "name": "HLX", "type": "recommended", "evidence": [ { "id": "A7MB54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB54" } ] }, { "name": "HLX1", "type": "synonym", "evidence": [ { "id": "NP_001094567", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094567" }, { "id": "A7MB54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB54" } ] }, { "name": "HLX", "type": "synonym", "evidence": [ { "id": "NP_001094567", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094567" } ] } ], "protein_names": [ { "name": "H2.0-like homeobox protein", "type": "recommended", "evidence": [ { "id": "A7MB54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB54/entry#names_and_taxonomy" } ] }, { "name": "H2.0-like homeobox protein", "type": "synonym", "evidence": [ { "id": "NP_001094567", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094567" } ] }, { "name": "Homeobox protein HLX1", "type": "synonym", "evidence": [ { "id": "A7MB54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB54/entry#names_and_taxonomy" } ] }, { "name": "homeobox protein HLX1", "type": "synonym", "evidence": [ { "id": "NP_001094567", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094567" } ] } ], "function": [ { "annotation": "Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A7MB54", "url": "https://www.uniprot.org/uniprotkb/A7MB54#function" }, { "database": "UniProtKB", "id": "Q61670", "url": "https://www.uniprot.org/uniprotkb/Q61670#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7MB54", "url": "https://www.uniprot.org/uniprotkb/A7MB54" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HLX", "url": "https://www.uniprot.org/uniprotkb/A7MB54", "locus": { "chromosome": "16", "start_pos": 24356593, "end_pos": 24350914, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014560", "url": "https://www.ensembl.org/id/ENSBTAG00000014560" } ] } } ], "crossref": [ { "id": "A7MB54", "url": "https://alphafold.ebi.ac.uk/entry/A7MB54", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014560", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014560", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "519165", "url": "https://www.ncbi.nlm.nih.gov/gene/519165", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020479", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020479", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052497", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052497", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519165", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519165", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VHHGGPF", "url": "https://omabrowser.org/oma/group/VHHGGPF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A7MB54", "url": "https://www.orthodb.org/?gene=A7MB54", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46808", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46808", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46808:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46808:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001094567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094567", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A7MB54", "url": "https://www.uniprot.org/uniprotkb/A7MB54", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7MB54-1", "url": "https://www.uniprot.org/uniprotkb/A7MB54-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFAAGLAPFYASNFSLWSAAYCSSAGPGGCSFPLDPAAVKKPSFCIADILHAGVGEPGATPEGLAGASAAALTAHLGSAHPHASFQAAARSPLRPTPVVAPSEVPAGFPQRLSPLSAAYHHHHPQQQQQQQQPQQQQPPPPPRAGALQPPASGSRVVPNPHQSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGGRPAGVHLPGLQPSAGQFFASLDPINEASAILSPLSSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGAPAPDGEPEERSPSRSEGEAESESSDPESLDMAPSDTERTEGTERSLHQTTVIKASAAGALLAASSGGSGGSGGGGGGGFNFGGLSSGSTTSAGSSGSHSSGGASELLPAPQPSLSSAPKSPEPVPAPLGGL", "length": 486, "header": "sp|A7MB54-1|HLX_BOVIN Isoform 1 of H2.0-like homeobox protein OS=Bos taurus OX=9913 GN=HLX PE=2 SV=1 CANONICAL=A7MB54-1" }, "isoforms": [ { "isoform_ac": "A7MB54-1", "url": "https://www.uniprot.org/uniprotkb/A7MB54/entry#A7MB54-1", "sequence": { "sequence": "MFAAGLAPFYASNFSLWSAAYCSSAGPGGCSFPLDPAAVKKPSFCIADILHAGVGEPGATPEGLAGASAAALTAHLGSAHPHASFQAAARSPLRPTPVVAPSEVPAGFPQRLSPLSAAYHHHHPQQQQQQQQPQQQQPPPPPRAGALQPPASGSRVVPNPHQSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGGRPAGVHLPGLQPSAGQFFASLDPINEASAILSPLSSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGAPAPDGEPEERSPSRSEGEAESESSDPESLDMAPSDTERTEGTERSLHQTTVIKASAAGALLAASSGGSGGSGGGGGGGFNFGGLSSGSTTSAGSSGSHSSGGASELLPAPQPSLSSAPKSPEPVPAPLGGL", "length": 486, "header": "sp|A7MB54-1|HLX_BOVIN Isoform 1 of H2.0-like homeobox protein OS=Bos taurus OX=9913 GN=HLX PE=2 SV=1 CANONICAL=A7MB54-1" }, "locus": { "chromosome": "16", "start_pos": 24356217, "end_pos": 24351367, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019352.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019352.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019352.3", "url": "https://www.ensembl.org/id/ENSBTAP00000019352.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 96, "start_aa": "Thr", "end_pos": 96, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr96", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:519165", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519165", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2R5H9-1", "protein_name": "H2.0-like homeobox protein", "gene_name": "HLX", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFAAGLAPFYAPNFSLWSAAYCSSAGPGGCSFPLDPAAVKKPSFCIADILHAGVGEPGAAPEGLAGASAAALTAHLGSAHPHASFQAAARSPLRPTPVVAPSEVPAGFPQRLSPLSAAYHHHHPQQQQQQQQPQQQQPPPPPRAGALQPPASGPRVVPNPHHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGRPAGVHLGLQPSTGQFFASLDPINEASAILSPLSSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGAVAADGEPEERSPSRSEAEAESESSDSESLDMTPSDTERTEGADRSLHPTTVIKASAAGALLAASSGGSGGSGGGGGGGGGGAAPRSCSPRPSPPSAAPPKAPSPPRRRWVASRLDKVGGDARPRRRLAALQCGMDFVPAFRWQQGQGRRREGRALMEGTHRCPRPAAHPSRSRGESSAPSTGLPAPSAHLGLDTSSSHCEVLD", "length": 556 }, "evidence": [ { "id": "A7MB54", "url": "https://omabrowser.org/oma/group/A7MB54/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Z3N7-1", "protein_name": "H2.0-like homeobox protein", "gene_name": "HLX", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MYTAGLAPFYASNFSLWSAAYCSAAGPAAGGCFPLEAAKKPSFCIADILHAGGEAAAGPADAAPGLPAAAAAALGSILPGGPFHAAASPLRPTPVVAPDTSSGAAAAAAAFPPRLSPLSAAFHPPHHHRAPQHRNPAAAAAAAAAPGGGGGTPARGPGGHTGGSAPAPASKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLSTSRQAGVHLPALQPSAGQFFASLEPINEASALLGPLNTAPRSSVQHQFQDTFPGPYAVLTKDTLPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKEPPPEPEPAAPRAVPPPAAAGEPERSPSRSDGDGDSDSSDPDSLDMAPSDTERTEGAEQSQPQAGGCRPSSSPGLPSPPPASASPEEL", "length": 430 }, "evidence": [ { "id": "A7MB54", "url": "https://omabrowser.org/oma/group/A7MB54/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0JPN1-1", "protein_name": "H2.0-like homeobox protein", "gene_name": "Hlx", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFAAGLAPFYASNFSLWSAAYCSSAGPGGCSFALDPAAVKKPSFCIADILHAGVGEPGPAAEGLVGASAALTAHLGSVHPHASFQAAARSPLRPTPVVAPSEVPAGFPQRLSPLSAAYHQHLPQQPPTQQQQPQQQPPPPPRAGSLQPPTSGTRVVPHHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGGRPTGVHLAGLQPSAGQFFASLDPISEASAILSPLSSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGVPAEGEREERSPSRSEGEAESESSDSESLDMAPSDTERTEGTERSLHQTTVIKASAAGALITASSSASGSSFSFSSSSSLGSSNGSAGSASSLGSNCSELLPSHQPSVTSGPQSPEIAQVPLAGL", "length": 476 }, "evidence": [ { "id": "A7MB54", "url": "https://omabrowser.org/oma/group/A7MB54/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q14774-1", "protein_name": "H2.0-like homeobox protein", "gene_name": "HLX", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFAAGLAPFYASNFSLWSAAYCSSAGPGGCSFPLDPAAVKKPSFCIADILHAGVGDLGAAPEGLAGASAAALTAHLGSVHPHASFQAAARSPLRPTPVVAPSEVPAGFPQRLSPLSAAYHHHHPQQQQQQQQPQQQQPPPPPRAGALQPPASGTRVVPNPHHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGGRPAGVHLSGLQPSAGQFFASLDPINEASAILSPLNSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGAPAADGEQDERSPSRSEGEAESESSDSESLDMAPSDTERTEGSERSLHQTTVIKAPVTGALITASSAGSGGSSGGGGNSFSFSSASSLSSSSTSAGCASSLGGGGASELLPATQPTASSAPKSPEPAQGALGCL", "length": 488 }, "evidence": [ { "id": "A7MB54", "url": "https://omabrowser.org/oma/group/A7MB54/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q61670-1", "protein_name": "H2.0-like homeobox protein", "gene_name": "Hlx", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFAAGLAPFYASNFSLWSAAYCSSAGPGGCSFALDPAAVKKPSFCIADILHAGVGEPGPAAEGLVGASAALTAHLGSVHPHASFQAAARSPLRPTPVVAPSEVPAGFPQRLSPLSAAFHQHLPQQSPTQQQQPQQQPPPPPRAVSLQPPTSGTRVVPHHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGGRPAGVHLAGLQPSAGQFFASLDPISEASAILSPLSSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGVPAEGEREERSPSRSEGEAESESSDSESLDMAPSDTERTEGTERSLHQTTVIKASAAGALITASSSTSGSSFSFSSTSSLGSGNTHVGSASSLGGNCSELPSAHQPSVTSSPQSPEIAQAPLAGL", "length": 476 }, "evidence": [ { "id": "A7MB54", "url": "https://omabrowser.org/oma/group/A7MB54/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A7MB54", "url": "https://www.uniprot.org/uniprotkb/A7MB54" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A7MB54", "url": "https://www.uniprot.org/uniprotkb/A7MB54" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A7MB54", "url": "https://www.uniprot.org/uniprotkb/A7MB54" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A7MB54", "url": "https://www.uniprot.org/uniprotkb/A7MB54" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A7MB54", "url": "https://www.uniprot.org/uniprotkb/A7MB54" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 13, "end_pos": 15, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7MB54-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 486, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7MB54-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7MB54" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A7MB54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB54" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Nucleotide_Binding_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000255", "start_pos": 276, "end_pos": 335, "start_aa": "Arg", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 96 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 13, "end_pos": 15 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A7MB73-1", "uniprot_ac": "A7MB73", "uniprot_id": "GT253_BOVIN", "mass": { "chemical_mass": 67466.0, "monoisotopic_mass": 67466.0 }, "refseq": { "ac": "NP_001095505", "name": "probable inactive glycosyltransferase 25 family member 3 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095505" }, "gene_names": [ { "name": "CERCAM", "type": "recommended", "evidence": [ { "id": "A7MB73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB73" } ] }, { "name": "CEECAM1", "type": "synonym", "evidence": [ { "id": "NP_001095505", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095505" }, { "id": "A7MB73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB73" } ] }, { "name": "CERCAM", "type": "synonym", "evidence": [ { "id": "NP_001095505", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095505" } ] }, { "name": "GLT25D3", "type": "synonym", "evidence": [ { "id": "A7MB73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB73" } ] } ], "protein_names": [ { "name": "Probable inactive glycosyltransferase 25 family member 3", "type": "recommended", "evidence": [ { "id": "A7MB73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB73/entry#names_and_taxonomy" } ] }, { "name": "Cerebral endothelial cell adhesion molecule", "type": "synonym", "evidence": [ { "id": "A7MB73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB73/entry#names_and_taxonomy" } ] }, { "name": "glycosyltransferase 25 family member 3", "type": "synonym", "evidence": [ { "id": "NP_001095505", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095505" } ] }, { "name": "probable inactive glycosyltransferase 25 family member 3 precursor", "type": "synonym", "evidence": [ { "id": "NP_001095505", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095505" } ] }, { "name": "probable inactive glycosyltransferase 25 family member 3", "type": "synonym", "evidence": [ { "id": "NP_001095505", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095505" } ] } ], "function": [ { "annotation": "Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferase activity in vitro.", "evidence": [ { "database": "UniProtKB", "id": "A7MB73", "url": "https://www.uniprot.org/uniprotkb/A7MB73#function" }, { "database": "UniProtKB", "id": "Q5T4B2", "url": "https://www.uniprot.org/uniprotkb/Q5T4B2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7MB73", "url": "https://www.uniprot.org/uniprotkb/A7MB73" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CERCAM", "url": "https://www.uniprot.org/uniprotkb/A7MB73", "locus": { "chromosome": "11", "start_pos": 99016877, "end_pos": 99005557, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038139", "url": "https://www.ensembl.org/id/ENSBTAG00000038139" } ] } } ], "crossref": [ { "id": "A7MB73", "url": "https://alphafold.ebi.ac.uk/entry/A7MB73", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038139", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038139", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00761", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00761", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06532", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06532", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "516122", "url": "https://www.ncbi.nlm.nih.gov/gene/516122", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002654", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002654", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050757", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050757", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516122", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516122", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VEVHVCN", "url": "https://omabrowser.org/oma/group/VEVHVCN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A7MB73", "url": "https://www.orthodb.org/?gene=A7MB73", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10730", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10730", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10730:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10730:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01755", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01755", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13704", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13704", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095505", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A7MB73", "url": "https://www.uniprot.org/uniprotkb/A7MB73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7MB73-1", "url": "https://www.uniprot.org/uniprotkb/A7MB73-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRAAPAAPLLQLLLLLGPRPEAAGVAEPPLPTVVLAILARNAEHSLPHYLGALERLDYPRARLALWCATDHNVDNTTAMLREWLAAVGDNYAAVVWRPEGEPRSYPDEEGPKHWTKERHQFLMELKQEALTFARDWGADYILFADTDNILTNNQTLRLLIEPGLPVVAPMLDSQTYYSNFWCGITPQGYYRRTADYFPTKNRQRRGCFRVPMVHSTFLVSLRAEGTGQLAFYPPHPNYTWPFDDIIVFAYACQAAGVAVHVCNEQRYGYLNVPVKSHQGLEDERVNFIHLILEALVDGPPMWASAHVSRPPKRPSKMGFDEVFVISLARRPDRRERMLTSLWEMEISGRVVDAVDGRMLNSSVMRTLGVDLLPGYQDPYSGRTLTKGEVGCFLSHYSIWEEVVTRGLAQVVVFEDDVRFESNFKGRLEQLMEEVEAEKLPWDLIYLGRKQVNPEEEAVVEGLPHLVAAGYSYWTLAYVLSLAGARKLLASQPLRRMLPVDEFLPIMFDQHPNEQYKAHFWPRDLQAFSARPLLAAPTHYAGDSEWLSDTETSSPWDDDSGRLISWTGSYKTLRGPRLDLAGGSGHSLRPHPRDEL", "length": 595, "header": "sp|A7MB73-1|GT253_BOVIN Isoform 1 of Probable inactive glycosyltransferase 25 family member 3 OS=Bos taurus OX=9913 GN=CERCAM PE=2 SV=1 CANONICAL=A7MB73-1" }, "isoforms": [ { "isoform_ac": "A7MB73-1", "url": "https://www.uniprot.org/uniprotkb/A7MB73/entry#A7MB73-1", "sequence": { "sequence": "MRAAPAAPLLQLLLLLGPRPEAAGVAEPPLPTVVLAILARNAEHSLPHYLGALERLDYPRARLALWCATDHNVDNTTAMLREWLAAVGDNYAAVVWRPEGEPRSYPDEEGPKHWTKERHQFLMELKQEALTFARDWGADYILFADTDNILTNNQTLRLLIEPGLPVVAPMLDSQTYYSNFWCGITPQGYYRRTADYFPTKNRQRRGCFRVPMVHSTFLVSLRAEGTGQLAFYPPHPNYTWPFDDIIVFAYACQAAGVAVHVCNEQRYGYLNVPVKSHQGLEDERVNFIHLILEALVDGPPMWASAHVSRPPKRPSKMGFDEVFVISLARRPDRRERMLTSLWEMEISGRVVDAVDGRMLNSSVMRTLGVDLLPGYQDPYSGRTLTKGEVGCFLSHYSIWEEVVTRGLAQVVVFEDDVRFESNFKGRLEQLMEEVEAEKLPWDLIYLGRKQVNPEEEAVVEGLPHLVAAGYSYWTLAYVLSLAGARKLLASQPLRRMLPVDEFLPIMFDQHPNEQYKAHFWPRDLQAFSARPLLAAPTHYAGDSEWLSDTETSSPWDDDSGRLISWTGSYKTLRGPRLDLAGGSGHSLRPHPRDEL", "length": 595, "header": "sp|A7MB73-1|GT253_BOVIN Isoform 1 of Probable inactive glycosyltransferase 25 family member 3 OS=Bos taurus OX=9913 GN=CERCAM PE=2 SV=1 CANONICAL=A7MB73-1" }, "locus": { "chromosome": "11", "start_pos": 99016874, "end_pos": 99005569, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004595.8", "url": "https://www.ensembl.org/id/ENSBTAT00000004595.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004595.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004595.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 153, "start_aa": "Asn", "end_pos": 153, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn153", "evidence": [ { "id": "A7MB73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB73#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 237, "start_aa": "Asn", "end_pos": 237, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn237", "evidence": [ { "id": "A7MB73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB73#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 360, "start_aa": "Asn", "end_pos": 360, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn360", "evidence": [ { "id": "A7MB73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB73#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 75, "start_aa": "Asn", "end_pos": 75, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn75", "evidence": [ { "id": "A7MB73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB73#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:516122", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516122", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AHF9-1", "protein_name": "Cerebral endothelial cell adhesion molecule", "gene_name": "CERCAM", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGPLRCAALVLLLLLLLGTGTGTGTGGSPEPPRVVLALLARNAQHSLPHCLGALESLDFPAGNIALWCATDHNSDNTTAMLQEWLQAVGSNYHSVAWKAEEGPSSYPDELSPKHWSDKRYENLMRLKQEALSYARGLRADYILFVDTDSILTNNQTLTFLMAQNKSVVAPMLDSQTFYSNFWCGITPQGFYRRTADYFPTKNRQRRGCFAVPMVYATFLIDLRKEETAQLAFYPPHPNYTWAFDDIIVFAYSCQEAGAEVHVCNQQRFGYINVPVKAHQTLEDERVNFVHLTLEAMVDGPPMQRSRHISVPPKPLTKLGFDEIFLINLVRRPDRRRRMLESLQELEITARVVDAVDGSTLNSSDIKVLGVDLLPGYYDPFSGRTLTKGEVGCFLSHYNIWKEIVSQGLERVLVFEDDVRFEVSFPARLQQLMEELEEARHDWDLIYLGRKQVNAEDEAPVEGVQNLVVAGYSYWTLAYAISLRGAQKLLAAKPLSKMLPVDEFLPIMYDKHPNEDYKRHFAPRDLQVFSAHPLLVYPTHYAGDSNWLSDTETSTIWDDDSKQTGWVGSQKTLRDPRDGGGYLRSASHDEF", "length": 590 }, "evidence": [ { "id": "A7MB73", "url": "https://omabrowser.org/oma/group/A7MB73/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A3KGW5-1", "protein_name": "Inactive glycosyltransferase 25 family member 3", "gene_name": "Cercam", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHVARLLPLLLLLGQQLRAASVTEPTLPTVVLAILARNAEHSLPHYLGALERLDYPRARLALWCATDHNMDNTTGMLREWLAAVGRDYATVVWKPEEEARSYPDEQGPKHWTKERHQFLMELRQEALAFARDWGADYILFADTDNILTNNQTLKLLIDRQLPVVAPMLDSQTYYSNFWCGITPQGYYRRTAEYFPTKNRQRQGCFRVPMVHSTFLLSLQTEETARLAFYPPHPNYSWPFDDIIVFAYACQAAGVSMHVCNDHRYGYMNVVVKPHQSLEEEKTNFIHLILEALVDGPPMLASAHVSRPPKKLSKMGFDEVFVISLARRPQRRARMLSSLWEMEISAQVVDAVDGRTLNSSILKHLGVDLLPGYQDPYSGHTLTKGEVGCFLSHYSIWEEVVARGLARVVVFEDDVRFKDNFRRRLERLMEDVLIQKLSWDLIYLGRKQVNPEEEVAVEGLPGLVVAGYSYWTLAYTLSLAGARKLLASQPLHRMLPVDEFLPVMFDRHPNDQYKAYFWPRDLQAFSARPLLASPTHYSGDAEWLSDTETSSPWDDDSGRLISQTGSQKALRGPHLHLTGSSGHSLHPHHRDEL", "length": 592 }, "evidence": [ { "id": "A7MB73", "url": "https://omabrowser.org/oma/group/A7MB73/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1RR83-1", "protein_name": "Cerebral endothelial cell adhesion molecule", "gene_name": "CERCAM", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRAAPAAPLLQLLLLLGPRLQAAGIAEPPLPTVVLVILARNAEHSLPHYLGALERLDYPRARLALWCATDHNEDSTTEMLQEWLAAVGEDYAAVVWRPEGEPRSYPDEEGPKHWTKERHQFLMELKQEALTFARDWGADYILFADTDNILTNNQTLRLLIEQQLPVVAPMLDSQTYYSNFWCGITPQGYYRRTAEYFPTKNRQRRGCFRVPMVHSTFLISLRAEGTGQLSFYPPHPNYTWPFDDIIVFAYACQAAGVSVHVCNEHRYGYMNVPVKSHQGLEDERVNFIHLLLEALVDGPPMWASAHVSRPPKRPSKMGFDEVFVISLARRPDRRERMLSSLWEMEIAGRVVDAVDGRMLNSSVMRRLGVDLLPGYQDPYSGRTLTKGEVGCFLSHYSIWEEVVAQGLAQVVVFEDDVRFESNFRGRLERLMEEVEAEKLPWDLIYLGRKQVNPEEEAAVEGLPQLVVAGYSYWTLAYVLSLAGARKLLASQPLRRMLPVDEFLPIMFDQHPNEQYKAHFWPRDLRAFSARPLLAAPTHYAGDAEWLSDTETSSPWDDDSGRLISWSGSYKTLRDPRLDLAGSSGHSLHPRPQDEL", "length": 595 }, "evidence": [ { "id": "A7MB73", "url": "https://omabrowser.org/oma/group/A7MB73/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5T4B2-1", "protein_name": "Inactive glycosyltransferase 25 family member 3", "gene_name": "CERCAM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRAARAAPLLQLLLLLGPWLEAAGVAESPLPAVVLAILARNAEHSLPHYLGALERLDYPRARMALWCATDHNVDNTTEMLQEWLAAVGDDYAAVVWRPEGEPRFYPDEEGPKHWTKERHQFLMELKQEALTFARNWGADYILFADTDNILTNNQTLRLLMGQGLPVVAPMLDSQTYYSNFWCGITPQGYYRRTAEYFPTKNRQRRGCFRVPMVHSTFLASLRAEGADQLAFYPPHPNYTWPFDDIIVFAYACQAAGVSVHVCNEHRYGYMNVPVKSHQGLEDERVNFIHLILEALVDGPRMQASAHVTRPSKRPSKIGFDEVFVISLARRPDRRERMLASLWEMEISGRVVDAVDGWMLNSSAIRNLGVDLLPGYQDPYSGRTLTKGEVGCFLSHYSIWEEVVARGLARVLVFEDDVRFESNFRGRLERLMEDVEAEKLSWDLIYLGRKQVNPEKETAVEGLPGLVVAGYSYWTLAYALRLAGARKLLASQPLRRMLPVDEFLPIMFDQHPNEQYKAHFWPRDLVAFSAQPLLAAPTHYAGDAEWLSDTETSSPWDDDSGRLISWSGSQKTLRSPRLDLTGSSGHSLQPQPRDEL", "length": 595 }, "evidence": [ { "id": "A7MB73", "url": "https://omabrowser.org/oma/group/A7MB73/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5U309-1", "protein_name": "Probable inactive glycosyltransferase 25 family member 3", "gene_name": "Cercam", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLFIIRARACGGDARSWKQPDQLHPILFTNLRLPLQLIASSAGGATDHNVDNTTGMLQEWLAAVGRDYATVVWKSEDEARSYPDEQGPKHWTRERHQFLMELKQEALAFARDWGADYILFADTDNILTNNQTLRLLIDRQLPVVAPMLDSQTYYSNFWCGITPQGYYRRTAEYFPTKNRQRQGCFRVPMVHSTFLVSLQTEETARLAFYPPHPNYTWPFDDIIVFAYACQAAGVSVHVCNDHRYGYMNVGVKPHQGLEEEKTNFIHLILEALVDGPPMMASAHVSRPPKKPSKMGFDEVFVISLARRPQRRARMLSSLWEMEISARVVDAVDGRTLNSSILKHLGVDLLPGYQDPYSGRTLTKGEVGCFLSHYSIWEEVVAKGLARVVVFEDDVRFEDNFRKRLERLMEDVLTQKLSWDLIYLGRKQVNPEEEVAVEGLPGLVVAGYSYWTLAYTLSLAGARKLLASQPLHRMLPVDEFLPVMFDRHPNDQYKAHFWPRDLQAFSARPLLASPTHYAGDTEWLSDTETSSPWDDDSGRLISWTGSQKTLRGPYLHLAGSSGHSLHPHPRDEL", "length": 572 }, "evidence": [ { "id": "A7MB73", "url": "https://omabrowser.org/oma/group/A7MB73/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "A7MB73", "url": "https://www.uniprot.org/uniprotkb/A7MB73" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A7MB73", "url": "https://www.uniprot.org/uniprotkb/A7MB73" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A7MB73", "url": "https://www.uniprot.org/uniprotkb/A7MB73" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 153, "end_pos": 155, "annotation": "n_glycosylation_sequon" }, { "start_pos": 237, "end_pos": 239, "annotation": "n_glycosylation_sequon" }, { "start_pos": 360, "end_pos": 362, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7MB73-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 595, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7MB73-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7MB73" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A7MB73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB73" }, { "id": "PRU10138", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU10138" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Prevents secretion from ER", "eco_id": "ECO_0000255", "start_pos": 592, "end_pos": 595, "start_aa": "Arg", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 75, 153, 237, 360 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 153, "end_pos": 155 }, { "start_pos": 237, "end_pos": 239 }, { "start_pos": 360, "end_pos": 362 }, { "start_pos": 75, "end_pos": 77 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 4 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_n_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 4 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_n_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A7MB75-1", "uniprot_ac": "A7MB75", "uniprot_id": "TM231_BOVIN", "mass": { "chemical_mass": 36004.0, "monoisotopic_mass": 36004.0 }, "refseq": { "ac": "NP_001094548", "name": "transmembrane protein 231", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094548" }, "gene_names": [ { "name": "TMEM231", "type": "recommended", "evidence": [ { "id": "A7MB75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB75" } ] }, { "name": "TMEM231", "type": "synonym", "evidence": [ { "id": "NP_001094548", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094548" } ] } ], "protein_names": [ { "name": "Transmembrane protein 231", "type": "recommended", "evidence": [ { "id": "A7MB75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB75/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 231", "type": "synonym", "evidence": [ { "id": "NP_001094548", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094548" } ] } ], "function": [ { "annotation": "Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A7MB75", "url": "https://www.uniprot.org/uniprotkb/A7MB75#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7MB75", "url": "https://www.uniprot.org/uniprotkb/A7MB75" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM231", "url": "https://www.uniprot.org/uniprotkb/A7MB75", "locus": { "chromosome": "18", "start_pos": 2842869, "end_pos": 2863808, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015432", "url": "https://www.ensembl.org/id/ENSBTAG00000015432" } ] } } ], "crossref": [ { "id": "A7MB75", "url": "https://alphafold.ebi.ac.uk/entry/A7MB75", "database": "AlphaFoldDB", "categories": [] }, { "id": "511832", "url": "https://www.ncbi.nlm.nih.gov/gene/511832", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019306", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019306", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511832", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511832", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PALYTRY", "url": "https://omabrowser.org/oma/group/PALYTRY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A7MB75", "url": "https://www.orthodb.org/?gene=A7MB75", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14605", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14605", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14605:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14605:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10149", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10149", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001094548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094548", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A7MB75", "url": "https://www.uniprot.org/uniprotkb/A7MB75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7MB75-1", "url": "https://www.uniprot.org/uniprotkb/A7MB75-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALYELFAHPVERGYRAGLCSKAALFLLLATALTYIPPLLVAFRSHGFWLKRSSYEEQPTVRFQHQVLLVALLGSEPGGFLAWSTFPAFNRLQEGHLRVPLVSAREEDRNQDGKMDMLHFKLELPLQSTEQVLGVQLILTFSYQLHRMSTFVMQSMAFLQSSFALPGSQLYVNGDLRLQQKQPLGYGGLDVRYNVSVINGTSPFASDYDLTRIVAAYQERNVTTILTDPSPIWLVGRAAEAPFVVNAVIRYPVEVISYLPGFWEMIKFAWIQYVSILLIFLWAFERIKRFVFQNQVVTTIPVTAMPQGELYKEHLS", "length": 316, "header": "sp|A7MB75-1|TM231_BOVIN Isoform 1 of Transmembrane protein 231 OS=Bos taurus OX=9913 GN=TMEM231 PE=2 SV=1 CANONICAL=A7MB75-1" }, "isoforms": [ { "isoform_ac": "A7MB75-1", "url": "https://www.uniprot.org/uniprotkb/A7MB75/entry#A7MB75-1", "sequence": { "sequence": "MALYELFAHPVERGYRAGLCSKAALFLLLATALTYIPPLLVAFRSHGFWLKRSSYEEQPTVRFQHQVLLVALLGSEPGGFLAWSTFPAFNRLQEGHLRVPLVSAREEDRNQDGKMDMLHFKLELPLQSTEQVLGVQLILTFSYQLHRMSTFVMQSMAFLQSSFALPGSQLYVNGDLRLQQKQPLGYGGLDVRYNVSVINGTSPFASDYDLTRIVAAYQERNVTTILTDPSPIWLVGRAAEAPFVVNAVIRYPVEVISYLPGFWEMIKFAWIQYVSILLIFLWAFERIKRFVFQNQVVTTIPVTAMPQGELYKEHLS", "length": 316, "header": "sp|A7MB75-1|TM231_BOVIN Isoform 1 of Transmembrane protein 231 OS=Bos taurus OX=9913 GN=TMEM231 PE=2 SV=1 CANONICAL=A7MB75-1" }, "locus": { "chromosome": "18", "start_pos": 2863732, "end_pos": 2844516, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020510.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020510.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020510.4", "url": "https://www.ensembl.org/id/ENSBTAP00000020510.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 194, "start_aa": "Asn", "end_pos": 194, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn194", "evidence": [ { "id": "A7MB75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB75#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 199, "start_aa": "Asn", "end_pos": 199, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn199", "evidence": [ { "id": "A7MB75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB75#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 221, "start_aa": "Asn", "end_pos": 221, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn221", "evidence": [ { "id": "A7MB75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB75#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:511832", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511832", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1NNL1-1", "protein_name": "Transmembrane protein 231", "gene_name": "TMEM231", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGVELFSHPALHTRYRAGLCSAAALALLLIAVLTYVPPLLVAYRSHGFWLKQSAYREQPTVRFRYELLFVATTGPGPGSFLAWSTFPAFNRLQEDRLRVPLLSTREEDKNQDGKMDQLHFKLELPLQPTEHVVGVQLILIFSYQLYRMSTFVMQSMAFLQFFSPVPGSQLYANGDLKLNQRQLLNHCGLDTRYNVSVVNGTSPFASDYDLKNIIAAYRDRNVTTVFSDSNPIWMTGRGANTPFIVNATIRYPVEVILYQPGFWETIKFAWIQYVSILLIFLWVFGRIKMFVFQNQVFATTPVSPVLPLSPVLSYKQHQP", "length": 320 }, "evidence": [ { "id": "A7MB75", "url": "https://omabrowser.org/oma/group/A7MB75/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S455-1", "protein_name": "Transmembrane protein 231", "gene_name": "TMEM231", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALHELFSHPVERGYRAGLCSKAALFLLLATALTYIPPLLVAFRSHGFWLKRSSYEEQPTVRFQHQVLLVALLGPEHAHGGFLAWSTFPAFNRLQGDHLRVPLVSTREEDRNQDGKMDVLHFKLELPLRSTEHVLGVQLILTFSYQLHRMSTFMMQSMAFLQASFAVPGSQLYVNGDLRLQQRQPLSYRGLDVRYNVSVINSSSPFARDYDLTHIVAAYQERNVTTILTNPNPIWLVGRAAEAPFVINAVIRYPVEVISYLPGFWEMIKFAWVQYVSILLIFLWVFERIKRFVFQNQVVTTVPVTAGSQGEPYKEHLS", "length": 318 }, "evidence": [ { "id": "A7MB75", "url": "https://omabrowser.org/oma/group/A7MB75/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3I4N6-1", "protein_name": "Transmembrane protein 231", "gene_name": "Tmem231", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MALYQLFSHPAERGYRAGLCSKAALFLLLATVLTYIPPLLVAFRSHGFWLKRSSYEEQPSVRFQHQVLLVALLGPEPGAFLAWSTFPTFNRLQGVHLRVPLVSSREEDRNQDGKMDVLHFRLELPLQATEHVLGVQLILTFSYQLHRMSTFVMQSMAFLQSSFAVPGSQLYVNGDLRLQQKQPLSYRGLDVRYNVSVINGTSPFAHDYDLTHIVAAYQERNVTTFLSDPNPVWLVGRAAEAPFVINAVIRYPVEVISYQPGFWEMIKFAWVQYVSILLIFIWVFERIKIFVFQNQVVTSIPVAVPQGELGKEHLS", "length": 315 }, "evidence": [ { "id": "A7MB75", "url": "https://omabrowser.org/oma/group/A7MB75/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q3U284-1", "protein_name": "Transmembrane protein 231", "gene_name": "Tmem231", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALYHLFSHPIERAYRAGLCSKAALFLLLTTALTYIPPLLVAFRSHGFWLKRSSYEEQPNVRFQHQVLLVALLGPEPEAFLAWSTFPTFNRLQGAHLRVPLVSSREEDRNQDGKMDVLYFKLELPLQPTEHVLGVQLILTFSYQLHRMSTFEMQSMAFLQSSFAVPGSQLYVNGDLRLQQKQPLSYRGLDIRYNVSVINGTSPFAQDYDLTHIVAAYQERNVTTVLSDPNPIWLVGRAAEAPFVIHAVIRYPTEVISYQPGFWEMIKFAWIQYVSILLIFLWVFERIKIFVFQNQVVTSIPVAVPQGEIRKEHLS", "length": 315 }, "evidence": [ { "id": "A7MB75", "url": "https://omabrowser.org/oma/group/A7MB75/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7T316-1", "protein_name": "Transmembrane protein 231", "gene_name": "tmem231", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAFYDVYAHPALIRYRTCVCTRATLFVCVVLGLTYISPLLVAYRSQGFWLKRNSYEEQPVVKFQYDLILLGVTDTTGNYLAWSTFPNFNRLIGDNLRIPEISAQEEDKNQDGKSDVLLLQISVPLKPAEQMFSVQLLLTFSYQLFRMSTVVMQTLAFIQHSSPVPGSQLFICGDLRLNQRTPLPHRGLHSTYNVSVIDGSSPFASTYDLTNIIRLYQQRNLTTHLSGVIPVWTVGRAANAPFQISAQIHYPVEMIDYRPGFWETIKFAWIQYVSVLLIFLWVFQHIQTFIFQNQVLPTITIPPFKQHRS", "length": 309 }, "evidence": [ { "id": "A7MB75", "url": "https://omabrowser.org/oma/group/A7MB75/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9H6L2-1", "protein_name": "Transmembrane protein 231", "gene_name": "TMEM231", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALYELFSHPVERSYRAGLCSKAALFLLLAAALTYIPPLLVAFRSHGFWLKRSSYEEQPTVRFQHQVLLVALLGPESDGFLAWSTFPAFNRLQGDRLRVPLVSTREEDRNQDGKTDMLHFKLELPLQSTEHVLGVQLILTFSYRLHRMATLVMQSMAFLQSSFPVPGSQLYVNGDLRLQQKQPLSCGGLDARYNISVINGTSPFAYDYDLTHIVAAYQERNVTTVLNDPNPIWLVGRAADAPFVINAIIRYPVEVISYQPGFWEMVKFAWVQYVSILLIFLWVFERIKIFVFQNQVVTTIPVTVTPRGDLCKEHLS", "length": 316 }, "evidence": [ { "id": "A7MB75", "url": "https://omabrowser.org/oma/group/A7MB75/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of protein localization", "id": "GO:0032880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032880", "evidence": [ { "database": "UniProtKB", "id": "A7MB75", "url": "https://www.uniprot.org/uniprotkb/A7MB75" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A7MB75", "url": "https://www.uniprot.org/uniprotkb/A7MB75" } ], "pmid": "" }, { "name": "smoothened signaling pathway", "id": "GO:0007224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007224", "evidence": [ { "database": "UniProtKB", "id": "A7MB75", "url": "https://www.uniprot.org/uniprotkb/A7MB75" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "MKS complex", "id": "GO:0036038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036038", "evidence": [ { "database": "UniProtKB", "id": "A7MB75", "url": "https://www.uniprot.org/uniprotkb/A7MB75" } ], "pmid": "" }, { "name": "ciliary membrane", "id": "GO:0060170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060170", "evidence": [ { "database": "UniProtKB", "id": "A7MB75", "url": "https://www.uniprot.org/uniprotkb/A7MB75" } ], "pmid": "" }, { "name": "ciliary transition zone", "id": "GO:0035869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035869", "evidence": [ { "database": "UniProtKB", "id": "A7MB75", "url": "https://www.uniprot.org/uniprotkb/A7MB75" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 199, "end_pos": 201, "annotation": "n_glycosylation_sequon" }, { "start_pos": 221, "end_pos": 223, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7MB75-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 316, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7MB75-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7MB75" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 194, 199, 221 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 194, "end_pos": 196 }, { "start_pos": 199, "end_pos": 201 }, { "start_pos": 221, "end_pos": 223 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A7MBC2-1", "uniprot_ac": "A7MBC2", "uniprot_id": "PDXD1_BOVIN", "mass": { "chemical_mass": 86615.0, "monoisotopic_mass": 86615.0 }, "refseq": { "ac": "NP_001095329", "name": "pyridoxal-dependent decarboxylase domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095329" }, "gene_names": [ { "name": "PDXDC1", "type": "recommended", "evidence": [ { "id": "A7MBC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBC2" } ] }, { "name": "PDXDC1", "type": "synonym", "evidence": [ { "id": "NP_001095329", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095329" } ] } ], "protein_names": [ { "name": "Pyridoxal-dependent decarboxylase domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A7MBC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBC2/entry#names_and_taxonomy" } ] }, { "name": "4.1.1.-", "type": "synonym", "evidence": [ { "id": "A7MBC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBC2/entry#names_and_taxonomy" } ] }, { "name": "pyridoxal-dependent decarboxylase domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001095329", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095329" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7MBC2", "url": "https://www.uniprot.org/uniprotkb/A7MBC2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PDXDC1", "url": "https://www.uniprot.org/uniprotkb/A7MBC2", "locus": { "chromosome": "25", "start_pos": 13731838, "end_pos": 13786631, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004801", "url": "https://www.ensembl.org/id/ENSBTAG00000004801" } ] } } ], "crossref": [ { "id": "A7MBC2", "url": "https://alphafold.ebi.ac.uk/entry/A7MBC2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004801", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004801", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505868", "url": "https://www.ncbi.nlm.nih.gov/gene/505868", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050477", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050477", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055102", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055102", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505868", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505868", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RLQYACR", "url": "https://omabrowser.org/oma/group/RLQYACR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A7MBC2", "url": "https://www.orthodb.org/?gene=A7MBC2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42735", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42735", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42735:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42735:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00282", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00282", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22930", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22930", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001095329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095329", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A7MBC2", "url": "https://www.uniprot.org/uniprotkb/A7MBC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7MBC2-1", "url": "https://www.uniprot.org/uniprotkb/A7MBC2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDASLEKKIADPTLAEMGKNLKEAMKMLEDSQRRTEEENGKKLLSGDIPGPLQGSGQDMVSILQLVQNLMHGDEDEQPQSTRIQNIGEQGHISLLGHSLGAYISTLDKEKLRKLTTRILSDTTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNRKPVLYLSAAARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGKLPLLLVANAGTAAVGHTDKIGRLKEVCEQYGIWLHVEGVNLATLALGYVSSSVLAATKCDSMTLTPGPWLGLPAVPAVTLYKHDDPALTLVSGLTSNKPADKLRALPLWLSLQYLGLDGIVERIKHACQLSQRLQESLKKVNHIKILVEDELSSPVVVFRFFQELPGSDPGLNAIPAPSAAASAVGRERHSCDALNRWLGEQLKQLVPMSGLTVMDLEVEGTCVRFSPLMTAAVLGTRGEDVDQLVACVQSKLPVLTCTLQLREEFKQEVEATAGLLYVDDPNWPGIGVVRYEHANDDKSSLKLDPEGEKIHAGLLKKLNELESDLTFKMGPEYKSMKSCIYIGMASDDIDISELVETIAVTAREIEEDSRLLENMTEVVRKGIQEAQVQLQKANEERLLEEGVLRQIPVVGSVLNWFSPVQASQKGRTFNLTAGSLESTEHTYVYKVQGSGVTPPQTPTGTRTKQRLPGQKPFKRSLRGSDAISETSSVGHIEDLEKMEQSSGGQEASEANSHERHPEAPAPPEAEPPGALQDGAQGLQDDRPQVEEPESLR", "length": 787, "header": "sp|A7MBC2-1|PDXD1_BOVIN Isoform 1 of Pyridoxal-dependent decarboxylase domain-containing protein 1 OS=Bos taurus OX=9913 GN=PDXDC1 PE=2 SV=1 CANONICAL=A7MBC2-1" }, "isoforms": [ { "isoform_ac": "A7MBC2-1", "url": "https://www.uniprot.org/uniprotkb/A7MBC2/entry#A7MBC2-1", "sequence": { "sequence": "MDASLEKKIADPTLAEMGKNLKEAMKMLEDSQRRTEEENGKKLLSGDIPGPLQGSGQDMVSILQLVQNLMHGDEDEQPQSTRIQNIGEQGHISLLGHSLGAYISTLDKEKLRKLTTRILSDTTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNRKPVLYLSAAARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGKLPLLLVANAGTAAVGHTDKIGRLKEVCEQYGIWLHVEGVNLATLALGYVSSSVLAATKCDSMTLTPGPWLGLPAVPAVTLYKHDDPALTLVSGLTSNKPADKLRALPLWLSLQYLGLDGIVERIKHACQLSQRLQESLKKVNHIKILVEDELSSPVVVFRFFQELPGSDPGLNAIPAPSAAASAVGRERHSCDALNRWLGEQLKQLVPMSGLTVMDLEVEGTCVRFSPLMTAAVLGTRGEDVDQLVACVQSKLPVLTCTLQLREEFKQEVEATAGLLYVDDPNWPGIGVVRYEHANDDKSSLKLDPEGEKIHAGLLKKLNELESDLTFKMGPEYKSMKSCIYIGMASDDIDISELVETIAVTAREIEEDSRLLENMTEVVRKGIQEAQVQLQKANEERLLEEGVLRQIPVVGSVLNWFSPVQASQKGRTFNLTAGSLESTEHTYVYKVQGSGVTPPQTPTGTRTKQRLPGQKPFKRSLRGSDAISETSSVGHIEDLEKMEQSSGGQEASEANSHERHPEAPAPPEAEPPGALQDGAQGLQDDRPQVEEPESLR", "length": 787, "header": "sp|A7MBC2-1|PDXD1_BOVIN Isoform 1 of Pyridoxal-dependent decarboxylase domain-containing protein 1 OS=Bos taurus OX=9913 GN=PDXDC1 PE=2 SV=1 CANONICAL=A7MBC2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 653, "end_pos": 653, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7MBC2", "url": "https://www.uniprot.org/uniprotkb/A7MBC2" } ], "site_lbl": "Ser653" }, { "start_pos": 688, "end_pos": 688, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A7MBC2", "url": "https://www.uniprot.org/uniprotkb/A7MBC2" } ], "site_lbl": "Thr688" }, { "start_pos": 692, "end_pos": 692, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A7MBC2", "url": "https://www.uniprot.org/uniprotkb/A7MBC2" } ], "site_lbl": "Thr692" }, { "start_pos": 711, "end_pos": 711, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7MBC2", "url": "https://www.uniprot.org/uniprotkb/A7MBC2" } ], "site_lbl": "Ser711" }, { "start_pos": 719, "end_pos": 719, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7MBC2", "url": "https://www.uniprot.org/uniprotkb/A7MBC2" } ], "site_lbl": "Ser719" }, { "start_pos": 723, "end_pos": 723, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7MBC2", "url": "https://www.uniprot.org/uniprotkb/A7MBC2" } ], "site_lbl": "Ser723" }, { "start_pos": 747, "end_pos": 747, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7MBC2", "url": "https://www.uniprot.org/uniprotkb/A7MBC2" } ], "site_lbl": "Ser747" }, { "start_pos": 785, "end_pos": 785, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A7MBC2", "url": "https://www.uniprot.org/uniprotkb/A7MBC2" } ], "site_lbl": "Ser785" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:505868", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505868", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K8S0-1", "protein_name": "Pyridoxal-dependent decarboxylase domain-containing protein 1", "gene_name": "Pdxdc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYTYGTTIADPTLAEMGKNLKEAMRMLENSPRRIEEESGKKPVPEDIPGPLQGSGQDMVSILQLVQNLMHGDEDEEPQSTRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSDTTLWLCRIFRYENGCAYFHEKEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPIIYLSAAARPGLGPYLCNQLGLPFPCLCRVPCNTMFGSQHQMDVAFLEKLIKDDVERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAATKCDSMTLTPGLWLGLPAVPAVTLYKHDDPALTLIAGLTSNKPADKLRALPLWLSLQYLGLDGIVGRIKHACQLSQRLQESLKKVDHIKILVEDELSSPVVVFRFFQELPTLDPAFKVAAVSNIAAAAVGRERHSCDALNRWLGEQLKQLVPQCGLTVMDLDIDGTCVRFSPLMTAEALGTRGEDVDQLITCIQSKLPVLTCTLQLREEFKKEVEGTAGLLYVDDPNWPGIGVVRYEHANDDNTSLQSDPEGEKIHTGLLKKLNELESDLTFKMGPEYKSMKSCIYIGMASDDVDVSELVETIAITAREIEENSRLLENMTEVVRKGIQEAQVQLQKANEERLLEEGVLRQIPVVGSVLNWFSPVQASQKGRSFNLTAGSLESTEYTYVYKVQGTGVTPPPTPSGTRSKQRLPGQKPFKRSLRSSDAVSETSSVSHIEDLEKVEQLPSGLEHDNLEAQCPEQPCRAADPVARQTEALQDEEDDHSQVEELERLR", "length": 783 }, "evidence": [ { "id": "A7MBC2", "url": "https://omabrowser.org/oma/group/A7MBC2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q66HY8-1", "protein_name": "Pyridoxal-dependent decarboxylase domain-containing protein 1", "gene_name": "pdxdc1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGNHLSDAMKILESGKLETEQGQEGRKMSWKEIPGPLQGDGQDVVSILQLVQNLMHGDDEEQGHRMQFVGEQGHMALLGHSLAAYISVLERERLRKLTTRILSDTTLWLCRLFRYENGSAYFHEDDREGLLKVCRLVMNTHYEDFTTEGFTALSSKHPVIYQSAACRPGLGQHLCSQLGLPLSCLCVVPCNTMFGSLHQMDVALLDKLVKDDRDSGKLPLLLIANAGTPGAGHTDKLSRLKELCVQYNMWLHVEGVNLATLVLGQVSSTVTAATKCDSMTLTPGPWLGLPAVPAVTLYRHEDPALSLAAGLTSSQPVEKLRALPLWLSLQYLGHDGIVERIKHASQLSQQLLEHLKTLASIKTSVEDELNSPVVVFRFSHENSAPSSGGSVEGSYAGERDILDAFNRWLGDQLAEQVPLSGVDVVELEDEGTCVRFSPLMTAAALGTQENDVAALVEKLAEMIPLLCCTLRLRQDFRDEVLQQASLSYIEDLNWPGLGVVRFEPRTTDLDEDKRQDRVEKINSDLLKKLMELDTDLNFSGGPEFSEEKNCIFIGIATEDLDVAELVETIMSLGRDIEESGKLFENMTEVVRKGIQEAELQLQKANEEKLMEEGVLRQIPLVSSVLNWFSPVQASVKGRTFNLAEGCLDSTEPVYSIKAQMRKEDSPDSPKANTRRFPGQKLFRRPGAGSDSISETSSVSQLEESFRETLHSQAADEAEVPQERPAHILEETAIADQRVPEGQEAESVETIR", "length": 751 }, "evidence": [ { "id": "A7MBC2", "url": "https://omabrowser.org/oma/group/A7MBC2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6P996-1", "protein_name": "Pyridoxal-dependent decarboxylase domain-containing protein 1", "gene_name": "PDXDC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDASLEKIADPTLAEMGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVSILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSDTTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSAAARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPGPWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHACQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGRERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVACIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPEGENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIEENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKGRTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSETSSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQVEGPESLR", "length": 788 }, "evidence": [ { "id": "A7MBC2", "url": "https://omabrowser.org/oma/group/A7MBC2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99K01-1", "protein_name": "Pyridoxal-dependent decarboxylase domain-containing protein 1", "gene_name": "Pdxdc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDASLEKIADPTLAEMGKNLKEAMRMLEKSPRRTEEENGKKPVSEDIPGPLQGSGQDMVSILQLVQNLMHGDEDEEPQSTRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSDTTLWLRRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSAAARPGLGQYLCNQLGLPFPCLCRVPCNTMFGSQHQMDVAFLEKLIKDDVERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAATKCDSMTLTPGLWLGLPAVPAVTLYKHDDPALTLVAGLTSNKPADKLRALPLWLSLQYLGLDGIVERIKHACHLSQRLQESLKKVDHIKILVEDELSSPVVVFRFFQELPASDSAFKAVPVSNIAPAAVGRERHSCDALNRWLGEQLKQLVPQCGLTVIDLEVDGTCVRFSPLMTAEGLGTRGEDVDQLITCIQSKLPVLTCTLQLREEFKQEVEGTAGLLYVDDPNWPGIGVVRYEHANDDDTSLKSDPEGEKIHTGLLKKLNELESDLTFKIGPEYKSMKSCIYIGMASDDVDVSELVETIAVTAREIEENSRLLENMTEVVRKGIQEAQVQLQKANEERLLEEGVLRQIPVVGSVLNWFSPVQASQKGRSFNLTAGSLESTEYTYVHKVQGTGVTPPPTPLGTRSKQRLPGQKPFKRSLRGSDAVSETSSVSHIEDLEKVEQLSSGLEHDNLEAHSPEQPPRATDLTARQTEALQNQAQHQEDDHSQVEELERLR", "length": 787 }, "evidence": [ { "id": "A7MBC2", "url": "https://omabrowser.org/oma/group/A7MBC2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VRG8-1", "protein_name": "Pyridoxal-dependent decarboxylase domain-containing protein 1", "gene_name": "Dmel\\CG1486", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSAAGRSVDDPGQSPLVDQEPDPGQSTPAVAEIAASSIRSGLAELELRSSQVLQRLENVKVSTTPESPNPVENEEEAGERVTSEDLLPAKHRVPSDILKSLEQLVSYTDSDDDPEFPLPALDDVSHLALISHSIVAYLSHLDRQQLLRVTNSISGDATRWLGTLFHFAHPASSFHADNADAVLRTVRLAIVARCPGYLEGGIPALAQPTFYISENTTPMRLHYACRQLGIPLEAIKVIPEHSQSGTMDVTLLQKQIQQDVGNNRTPLLVVADIGASLCGYVDNLLRLRDVCKAHNMWLHASGHGLAALVCAQNQGHVEEVLHSMALNLGSWLGVPSLPIVLLHRPLQNSALSAFESDPILSRRLNALSLWTSLQALGRKAIAERLHVAFQTCSILFEIASKCEGIRVLSHTPGAQTGASLSDVIQSPFDVQALFDAAAPVVAYQFDGSTTIPLGGSGSSAAAAAAERETAEGLKPLEKINNASYFDRLNSWLGQILQRDCPNFDFEVIEHPTHGSCIRYCPLELGLGEQPPSSENLESFAQSLEAHVDILRATIKHKARFIHLVECSDVLRLVPLPEWAGMGGVRFVPEGWESLLTDQAKTELNKLNIDLVEALKSTDNAFSLGEGTDGLICVRFGMVTHETEVEELLDLVVTVGKSVQENSRVLDTMSEIVKKGIEAVTADLQRESEEKLWQEGILRHVPVVGRVFNWWSPPAKESGIKGRSLNLTQGVVESTENIYKYHMQMTGATAHQLPANRSPPTPMVQTPVVAPALPPVFPTVEPVPGNGNGSGASEGTPVQSGEASGSMPAASGAAPSAAPTQNHVDHARTVSQSSAASSTVPELVAASSAINNN", "length": 852 }, "evidence": [ { "id": "A7MBC2", "url": "https://omabrowser.org/oma/group/A7MBC2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "A7MBC2", "url": "https://www.uniprot.org/uniprotkb/A7MBC2" } ], "pmid": "" }, { "name": "carboxy-lyase activity", "id": "GO:0016831", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016831", "evidence": [ { "database": "UniProtKB", "id": "A7MBC2", "url": "https://www.uniprot.org/uniprotkb/A7MBC2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "carboxylic acid metabolic process", "id": "GO:0019752", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019752", "evidence": [ { "database": "UniProtKB", "id": "A7MBC2", "url": "https://www.uniprot.org/uniprotkb/A7MBC2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 609, "end_pos": 611, "annotation": "n_glycosylation_sequon" }, { "start_pos": 665, "end_pos": 667, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7MBC2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 787, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7MBC2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7MBC2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 653, 688, 692, 711, 719, 723, 747, 785 ], "sequon_annotation_sites": [ { "start_pos": 609, "end_pos": 611 }, { "start_pos": 665, "end_pos": 667 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 8 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A7MBH3-1", "uniprot_ac": "A7MBH3", "uniprot_id": "NAIF1_BOVIN", "mass": { "chemical_mass": 35194.0, "monoisotopic_mass": 35194.0 }, "refseq": { "ac": "NP_001094544", "name": "nuclear apoptosis-inducing factor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094544" }, "gene_names": [ { "name": "NAIF1", "type": "recommended", "evidence": [ { "id": "A7MBH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBH3" } ] }, { "name": "H11C9ORF90", "type": "synonym", "evidence": [ { "id": "NP_001094544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094544" } ] }, { "name": "NAIF1", "type": "synonym", "evidence": [ { "id": "NP_001094544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094544" } ] } ], "protein_names": [ { "name": "Nuclear apoptosis-inducing factor 1", "type": "recommended", "evidence": [ { "id": "A7MBH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBH3/entry#names_and_taxonomy" } ] }, { "name": "nuclear apoptosis-inducing factor 1", "type": "synonym", "evidence": [ { "id": "NP_001094544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094544" } ] } ], "function": [ { "annotation": "Induces apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "A7MBH3", "url": "https://www.uniprot.org/uniprotkb/A7MBH3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7MBH3", "url": "https://www.uniprot.org/uniprotkb/A7MBH3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NAIF1", "url": "https://www.uniprot.org/uniprotkb/A7MBH3", "locus": { "chromosome": "11", "start_pos": 98706627, "end_pos": 98711496, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012156", "url": "https://www.ensembl.org/id/ENSBTAG00000012156" } ] } } ], "crossref": [ { "id": "A7MBH3", "url": "https://alphafold.ebi.ac.uk/entry/A7MBH3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012156", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012156", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510689", "url": "https://www.ncbi.nlm.nih.gov/gene/510689", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028002", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028002", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510689", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510689", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QQDGMIQ", "url": "https://omabrowser.org/oma/group/QQDGMIQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A7MBH3", "url": "https://www.orthodb.org/?gene=A7MBH3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23098", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23098", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23098:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23098:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13873", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13873", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001094544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094544", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A7MBH3", "url": "https://www.uniprot.org/uniprotkb/A7MBH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7MBH3-1", "url": "https://www.uniprot.org/uniprotkb/A7MBH3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVPAKKRKMNFSEREVEIIVEELELKKHLLVNHFNAGVPLAAKSAAWHGILRRVNAVATCRRELPEVKKKWSDLKTEVRRKVAQVRAAVEGGEAPGPTEEDGAGGPGTGGGSGAGGPAVAPVLLTPMQQRICNLLGEATIISLPSTAEIHPVALGPTATAAAATVTLTQIPTETTYHTLEEGVVEYCTAEAPPPLPAEAPVEMMAQHADTSVKPQALKSRIALNSAKLIQEQRVTNLHVKEIAQHLEQQNDLLQMIRRSQEVQACAQERQAQAMEGTQAALSVLIQVLRPMIKDFRRYLQSNMPNPATASEPGQVAQNGQPDSIIQ", "length": 327, "header": "sp|A7MBH3-1|NAIF1_BOVIN Isoform 1 of Nuclear apoptosis-inducing factor 1 OS=Bos taurus OX=9913 GN=NAIF1 PE=2 SV=1 CANONICAL=A7MBH3-1" }, "isoforms": [ { "isoform_ac": "A7MBH3-1", "url": "https://www.uniprot.org/uniprotkb/A7MBH3/entry#A7MBH3-1", "sequence": { "sequence": "MAVPAKKRKMNFSEREVEIIVEELELKKHLLVNHFNAGVPLAAKSAAWHGILRRVNAVATCRRELPEVKKKWSDLKTEVRRKVAQVRAAVEGGEAPGPTEEDGAGGPGTGGGSGAGGPAVAPVLLTPMQQRICNLLGEATIISLPSTAEIHPVALGPTATAAAATVTLTQIPTETTYHTLEEGVVEYCTAEAPPPLPAEAPVEMMAQHADTSVKPQALKSRIALNSAKLIQEQRVTNLHVKEIAQHLEQQNDLLQMIRRSQEVQACAQERQAQAMEGTQAALSVLIQVLRPMIKDFRRYLQSNMPNPATASEPGQVAQNGQPDSIIQ", "length": 327, "header": "sp|A7MBH3-1|NAIF1_BOVIN Isoform 1 of Nuclear apoptosis-inducing factor 1 OS=Bos taurus OX=9913 GN=NAIF1 PE=2 SV=1 CANONICAL=A7MBH3-1" }, "locus": { "chromosome": "11", "start_pos": 98711388, "end_pos": 98708470, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016123.4", "url": "https://www.ensembl.org/id/ENSBTAT00000016123.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016123.3", "url": "https://www.ensembl.org/id/ENSBTAP00000016123.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 158, "start_aa": "Thr", "end_pos": 158, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr158", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 99, "start_aa": "Thr", "end_pos": 99, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr99", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:510689", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510689", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M3B1Q7-1", "protein_name": "Nuclear apoptosis-inducing factor 1 isoform X1", "gene_name": "naif1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MASQAKKRKTNFSEREVEIIVEEMEKQKHILVNHFNAGVTHIAKNSAWMEILKRVNAVSTCQRELAEVKKKWSDLKTEVRRKVAQARAAMEGTGDCTTVPVILTSMQQRICNLLGEATIISLPAADAGTEIAVPISSAAAVTLTQSIQPATASACEIKTLEAETTYHTLEEGMVEYCTTETPVTVTAEAPVEMLTAQAECSNKPQELKSRIALNSAKLLQEHRVTNLHVREIAQHLENQNDLLQMIRRSQEAQACAQERQAQALEGTQAALLALIQMFRPALKDLRKFLQNANSTNTAAAATAAETGDGAENVPPQTEEGQ", "length": 321 }, "evidence": [ { "id": "A7MBH3", "url": "https://omabrowser.org/oma/group/A7MBH3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "M0R6C4-1", "protein_name": "Nuclear apoptosis inducing factor 1", "gene_name": "Naif1", 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"MNIRGTPDLGQPSDDPSSGGERERIRQRMKMVIGQLEDILRELKEVAKELREVVSQIDKLTSDFDFELEPDDWTTATVSSTSSSDKAGVGGPFDLGHLDFMTADILSDSWEFCSFLDISTPSDSVDCPESTRPGAGPDYQLMNGGLPVPNGPRVETPDSSSEEAFSAGPVKGQLPQRTPGTRERVRFSDKVLYHALCCDDEEGDGEEEAAEEEGGLSPEPAHTEAPAGPLKPSPAPYKPRRSPLTGRRSGPTSVPEQTRRVTRNSSTQTVSDKSTQTVLPYTATRQKAKGKN", "length": 292, "header": "sp|A7YWL5-1|INSY1_BOVIN Isoform 1 of Inhibitory synaptic factor 1 OS=Bos taurus OX=9913 GN=INSYN1 PE=2 SV=1 CANONICAL=A7YWL5-1" }, "isoforms": [ { "isoform_ac": "A7YWL5-1", "url": "https://www.uniprot.org/uniprotkb/A7YWL5/entry#A7YWL5-1", "sequence": { "sequence": "MNIRGTPDLGQPSDDPSSGGERERIRQRMKMVIGQLEDILRELKEVAKELREVVSQIDKLTSDFDFELEPDDWTTATVSSTSSSDKAGVGGPFDLGHLDFMTADILSDSWEFCSFLDISTPSDSVDCPESTRPGAGPDYQLMNGGLPVPNGPRVETPDSSSEEAFSAGPVKGQLPQRTPGTRERVRFSDKVLYHALCCDDEEGDGEEEAAEEEGGLSPEPAHTEAPAGPLKPSPAPYKPRRSPLTGRRSGPTSVPEQTRRVTRNSSTQTVSDKSTQTVLPYTATRQKAKGKN", "length": 292, "header": "sp|A7YWL5-1|INSY1_BOVIN Isoform 1 of Inhibitory synaptic factor 1 OS=Bos taurus OX=9913 GN=INSYN1 PE=2 SV=1 CANONICAL=A7YWL5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613490", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613490", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "A7YWL5", "url": "https://www.uniprot.org/uniprotkb/A7YWL5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "inhibitory postsynaptic potential", "id": "GO:0060080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060080", "evidence": [ { "database": "UniProtKB", "id": "A7YWL5", "url": "https://www.uniprot.org/uniprotkb/A7YWL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], 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"https://www.ncbi.nlm.nih.gov/protein/NP_001098853" }, { "id": "A7YWS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWS7/entry#names_and_taxonomy" } ] }, { "name": "DNA polymerase epsilon subunit 2", "type": "synonym", "evidence": [ { "id": "NP_001098853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098853" } ] }, { "name": "DNA polymerase epsilon subunit B", "type": "synonym", "evidence": [ { "id": "NP_001098853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098853" }, { "id": "A7YWS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWS7/entry#names_and_taxonomy" } ] }, { "name": "DNA-directed DNA polymerase epsilon 2", "type": "synonym", "evidence": [ { "id": "NP_001098853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098853" } ] }, { "name": "polymerase (DNA directed), epsilon 2 (p59 subunit)", "type": "synonym", "evidence": [ { "id": "NP_001098853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098853" } ] }, { "name": "polymerase (DNA directed), epsilon 2, accessory subunit", "type": "synonym", "evidence": [ { "id": "NP_001098853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098853" } ] } ], "function": [ { "annotation": "Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A7YWS7", "url": "https://www.uniprot.org/uniprotkb/A7YWS7#function" }, { "database": "UniProtKB", "id": "P56282", "url": "https://www.uniprot.org/uniprotkb/P56282#function" }, { "database": "UniProtKB", "id": "P24482", "url": "https://www.uniprot.org/uniprotkb/P24482#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7YWS7", "url": "https://www.uniprot.org/uniprotkb/A7YWS7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "POLE2", "url": "https://www.uniprot.org/uniprotkb/A7YWS7", "locus": { "chromosome": "10", "start_pos": 42673784, "end_pos": 42705622, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004931", "url": "https://www.ensembl.org/id/ENSBTAG00000004931" } ] } } ], "crossref": [ { "id": "A7YWS7", "url": "https://alphafold.ebi.ac.uk/entry/A7YWS7", "database": "AlphaFoldDB", "categories": [] }, { "id": "518653", "url": "https://www.ncbi.nlm.nih.gov/gene/518653", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024639", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024639", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518653", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518653", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A7YWS7", "url": "https://www.orthodb.org/?gene=A7YWS7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12708", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12708", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12708:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12708:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04042", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04042", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12213", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12213", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001098853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098853", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A7YWS7", "url": "https://www.uniprot.org/uniprotkb/A7YWS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7YWS7-1", "url": "https://www.uniprot.org/uniprotkb/A7YWS7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPERLRSRALSAFKLRGLMLRGEAVKYLTEALQSINEIELEDALEKIIDAVEKQPLSSNMIERSVVEAAVQECSQSVDETIDHIFNIIGAFDIPRFVYNSERKKFLPLLMTNHPAPNLFGTARDKAELFRERYTILHQRTHRHELFTPPVIGSHPDESGSKFQLKTIETLLGSTSKIGDVIVLGMITQLKEGKFFLEDPTGTIQLDLSKAQFHSGLYTESCFVLAEGWFEDQVFHVNAFGFPPTEPSSTTRAYYGNTNFFGGPSNTSVKTSAKLKQLEDENKDAMFVFISDVWLDQVEVLEKLHIMFSGYSPAPPTCFILCGNFSSAPYGKNQVQALKDSLKTLADIICGYPNIHQSSRFVFVPGPEDPGFGSILPRPPFAESITNEFRQRVPFSVFTTNPCRIQYCTQEIIVFREDLVNKMCRNCVRFPSSNLDIPNHFVKTVLSQGHLTPLPLYVCPVYWAYDYALRVYPVPDLLVIADKYDPFTLTNTECLCINPGSFPRSGFSFKVFYPSNKVVEDSKLQGF", "length": 527, "header": "sp|A7YWS7-1|DPOE2_BOVIN Isoform 1 of DNA polymerase epsilon subunit 2 OS=Bos taurus OX=9913 GN=POLE2 PE=2 SV=1 CANONICAL=A7YWS7-1" }, "isoforms": [ { "isoform_ac": "A7YWS7-1", "url": "https://www.uniprot.org/uniprotkb/A7YWS7/entry#A7YWS7-1", "sequence": { "sequence": "MAPERLRSRALSAFKLRGLMLRGEAVKYLTEALQSINEIELEDALEKIIDAVEKQPLSSNMIERSVVEAAVQECSQSVDETIDHIFNIIGAFDIPRFVYNSERKKFLPLLMTNHPAPNLFGTARDKAELFRERYTILHQRTHRHELFTPPVIGSHPDESGSKFQLKTIETLLGSTSKIGDVIVLGMITQLKEGKFFLEDPTGTIQLDLSKAQFHSGLYTESCFVLAEGWFEDQVFHVNAFGFPPTEPSSTTRAYYGNTNFFGGPSNTSVKTSAKLKQLEDENKDAMFVFISDVWLDQVEVLEKLHIMFSGYSPAPPTCFILCGNFSSAPYGKNQVQALKDSLKTLADIICGYPNIHQSSRFVFVPGPEDPGFGSILPRPPFAESITNEFRQRVPFSVFTTNPCRIQYCTQEIIVFREDLVNKMCRNCVRFPSSNLDIPNHFVKTVLSQGHLTPLPLYVCPVYWAYDYALRVYPVPDLLVIADKYDPFTLTNTECLCINPGSFPRSGFSFKVFYPSNKVVEDSKLQGF", "length": 527, "header": "sp|A7YWS7-1|DPOE2_BOVIN Isoform 1 of DNA polymerase epsilon subunit 2 OS=Bos taurus OX=9913 GN=POLE2 PE=2 SV=1 CANONICAL=A7YWS7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518653", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518653", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { 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"Ribonuclease P protein subunit p40", "type": "recommended", "evidence": [ { "id": "A7YWU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWU3/entry#names_and_taxonomy" } ] }, { "name": "RNaseP protein p40", "type": "synonym", "evidence": [ { "id": "NP_001098872", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098872" }, { "id": "A7YWU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWU3/entry#names_and_taxonomy" } ] }, { "name": "ribonuclease P protein subunit p40", "type": "synonym", "evidence": [ { "id": "NP_001098872", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098872" } ] } ], "function": [ { "annotation": "Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.", "evidence": [ { "database": "UniProtKB", "id": "A7YWU3", "url": "https://www.uniprot.org/uniprotkb/A7YWU3#function" }, { "database": "UniProtKB", "id": "O75818", "url": "https://www.uniprot.org/uniprotkb/O75818#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7YWU3", "url": "https://www.uniprot.org/uniprotkb/A7YWU3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPP40", "url": "https://www.uniprot.org/uniprotkb/A7YWU3", "locus": { "chromosome": "23", "start_pos": 49555816, "end_pos": 49546033, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003332", "url": "https://www.ensembl.org/id/ENSBTAG00000003332" } ] } } ], "crossref": [ { "id": "A7YWU3", "url": "https://alphafold.ebi.ac.uk/entry/A7YWU3", "database": "AlphaFoldDB", "categories": [] }, { "id": "531274", "url": "https://www.ncbi.nlm.nih.gov/gene/531274", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013893", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013893", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:531274", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531274", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A7YWU3", "url": "https://www.orthodb.org/?gene=A7YWU3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15396", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15396", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15396:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15396:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08584", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08584", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001098872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098872", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A7YWU3", "url": "https://www.uniprot.org/uniprotkb/A7YWU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7YWU3-1", "url": "https://www.uniprot.org/uniprotkb/A7YWU3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGFGPYYFVKGLPLYELITHEFINTFVKKGSCYALTYNTNIDEDNTVALLPNGKLILSLDKDTYEETGLQGCPSQYSGRKTMRFIVSIDLMDLSSNLDSKKYKRVSWAFKEKKPLKFDFLLAWHQTGAEGSTMMSYFSGYGIQEHQPKIALSTTPDLRCPVLRSGLLGGEPEAACSAHELFDWLGAVFSHADLNNEPYNFVSTYCCPQPSSVVAQASLCSVTGFLLPERICVLLEQLCRYFDEPKLAPWVTLSVQGFADSPVSWRESEHGFQKGGEHLYNFVIFNNRDYWLQMAVGADDDCPP", "length": 303, "header": "sp|A7YWU3-1|RPP40_BOVIN Isoform 1 of Ribonuclease P protein subunit p40 OS=Bos taurus OX=9913 GN=RPP40 PE=2 SV=2 CANONICAL=A7YWU3-1" }, "isoforms": [ { "isoform_ac": "A7YWU3-1", "url": "https://www.uniprot.org/uniprotkb/A7YWU3/entry#A7YWU3-1", "sequence": { "sequence": "MGFGPYYFVKGLPLYELITHEFINTFVKKGSCYALTYNTNIDEDNTVALLPNGKLILSLDKDTYEETGLQGCPSQYSGRKTMRFIVSIDLMDLSSNLDSKKYKRVSWAFKEKKPLKFDFLLAWHQTGAEGSTMMSYFSGYGIQEHQPKIALSTTPDLRCPVLRSGLLGGEPEAACSAHELFDWLGAVFSHADLNNEPYNFVSTYCCPQPSSVVAQASLCSVTGFLLPERICVLLEQLCRYFDEPKLAPWVTLSVQGFADSPVSWRESEHGFQKGGEHLYNFVIFNNRDYWLQMAVGADDDCPP", "length": 303, "header": "sp|A7YWU3-1|RPP40_BOVIN Isoform 1 of Ribonuclease P protein subunit p40 OS=Bos taurus OX=9913 GN=RPP40 PE=2 SV=2 CANONICAL=A7YWU3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:531274", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531274", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "multimeric ribonuclease P complex", "id": "GO:0030681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030681", "evidence": [ { "database": "UniProtKB", "id": "A7YWU3", "url": "https://www.uniprot.org/uniprotkb/A7YWU3" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A7YWU3", "url": "https://www.uniprot.org/uniprotkb/A7YWU3" } ], "pmid": "" }, { "name": "ribonuclease MRP complex", "id": "GO:0000172", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000172", "evidence": [ { "database": "UniProtKB", "id": "A7YWU3", "url": "https://www.uniprot.org/uniprotkb/A7YWU3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "id": "GO:0000447", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000447", "evidence": [ { "database": "UniProtKB", "id": "A7YWU3", "url": "https://www.uniprot.org/uniprotkb/A7YWU3" } ], "pmid": "" }, { "name": "tRNA 5'-leader removal", "id": "GO:0001682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001682", "evidence": [ { "database": "UniProtKB", "id": "A7YWU3", "url": "https://www.uniprot.org/uniprotkb/A7YWU3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ribonuclease P RNA binding", "id": "GO:0033204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033204", "evidence": [ { "database": "UniProtKB", "id": "A7YWU3", "url": "https://www.uniprot.org/uniprotkb/A7YWU3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A7YWU3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 303, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A7YWU3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A7YWU3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": 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"recommended", "evidence": [ { "id": "A7YY35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YY35" } ] }, { "name": "KIAA2012", "type": "synonym", "evidence": [ { "id": "NP_001098908", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098908" } ] } ], "protein_names": [ { "name": "Uncharacterized protein KIAA2012 homolog", "type": "recommended", "evidence": [ { "id": "A7YY35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YY35/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein KIAA2012 homolog", "type": "synonym", "evidence": [ { "id": "NP_001098908", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098908" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A7YY35", "url": "https://www.uniprot.org/uniprotkb/A7YY35" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KIAA2012", "url": "https://www.uniprot.org/uniprotkb/A7YY35", "locus": { "chromosome": "2", "start_pos": 90737262, "end_pos": 90611238, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034192", "url": "https://www.ensembl.org/id/ENSBTAG00000034192" } ] } } ], "crossref": [ { "id": "A7YY35", "url": "https://alphafold.ebi.ac.uk/entry/A7YY35", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034192", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034192", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614993", "url": "https://www.ncbi.nlm.nih.gov/gene/614993", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031440", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031440", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614993", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614993", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A7YY35", "url": "https://www.orthodb.org/?gene=A7YY35", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21937", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21937", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21937:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21937:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15709", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15709", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001098908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098908", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A7YY35", "url": "https://www.uniprot.org/uniprotkb/A7YY35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A7YY35-1", "url": "https://www.uniprot.org/uniprotkb/A7YY35-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"evidence": [ { "id": "A8E653", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A8E653/entry#names_and_taxonomy" } ] }, { "name": "Exocrine differentiation and proliferation factor-like protein", "type": "synonym", "evidence": [ { "id": "NP_001103437", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103437" }, { "id": "A8E653", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A8E653/entry#names_and_taxonomy" } ] }, { "name": "pancreatic progenitor cell differentiation and proliferation factor-like protein", "type": "synonym", "evidence": [ { "id": "NP_001103437", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103437" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A8E653", "url": "https://www.uniprot.org/uniprotkb/A8E653" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPDPFL", "url": "https://www.uniprot.org/uniprotkb/A8E653", "locus": { "chromosome": "14", "start_pos": 19986371, "end_pos": 19981881, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038286", "url": "https://www.ensembl.org/id/ENSBTAG00000038286" } ] } } ], "crossref": [ { "id": "A8E653", "url": "https://alphafold.ebi.ac.uk/entry/A8E653", "database": "AlphaFoldDB", "categories": [] }, { "id": "100126183", "url": "https://www.ncbi.nlm.nih.gov/gene/100126183", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026754", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026754", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100126183", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100126183", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A8E653", 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"length": 141, "header": "sp|A8E653-1|PDPFL_BOVIN Isoform 1 of Pancreatic progenitor cell differentiation and proliferation factor-like protein OS=Bos taurus OX=9913 GN=PPDPFL PE=2 SV=1 CANONICAL=A8E653-1" }, "isoforms": [ { "isoform_ac": "A8E653-1", "url": "https://www.uniprot.org/uniprotkb/A8E653/entry#A8E653-1", "sequence": { "sequence": "MASVPSAGCLLARNQYYRKASVSSGPSLTGPDSANFVGDDKTQLGLPKVAESTWWFKSFFQSVPVLNVKGEDQSACGGNGPGSRSKVPSGTNNHSLLQQEESQLLGEMADSGTVNRFRNSQTVKDKPRPFHGAPKDTNSPQ", "length": 141, "header": "sp|A8E653-1|PDPFL_BOVIN Isoform 1 of Pancreatic progenitor cell differentiation and proliferation factor-like protein OS=Bos taurus OX=9913 GN=PPDPFL PE=2 SV=1 CANONICAL=A8E653-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100126183", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100126183", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { 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{ "name": "SDHAF1", "type": "synonym", "evidence": [ { "id": "A8PU71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A8PU71/entry#names_and_taxonomy" } ] }, { "name": "succinate dehydrogenase assembly factor 1, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_001103912", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103912" } ] } ], "function": [ { "annotation": "Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3. Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20.", "evidence": [ { "database": "UniProtKB", "id": "A8PU71", "url": "https://www.uniprot.org/uniprotkb/A8PU71#function" }, { "database": "UniProtKB", "id": "A6NFY7", "url": "https://www.uniprot.org/uniprotkb/A6NFY7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A8PU71", "url": "https://www.uniprot.org/uniprotkb/A8PU71" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SDHAF1", "url": "https://www.uniprot.org/uniprotkb/A8PU71", "locus": { "chromosome": "18", "start_pos": 46670554, "end_pos": 46667770, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037461", "url": "https://www.ensembl.org/id/ENSBTAG00000037461" } ] } } ], "crossref": [ { "id": "A8PU71", "url": "https://alphafold.ebi.ac.uk/entry/A8PU71", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037461", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037461", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20268", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20268", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "784051", "url": "https://www.ncbi.nlm.nih.gov/gene/784051", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045295", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045295", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052687", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052687", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:784051", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784051", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MGTFVRP", "url": "https://omabrowser.org/oma/group/MGTFVRP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A8PU71", "url": "https://www.orthodb.org/?gene=A8PU71", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47046", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47046", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47046:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47046:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05347", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05347", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9854311", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9854311", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001103912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103912", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A8PU71", "url": "https://www.uniprot.org/uniprotkb/A8PU71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A8PU71-1", "url": "https://www.uniprot.org/uniprotkb/A8PU71-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRHSRLQRQVLSLYRELLRAGRGKPGAEARVRAEFRQHACLPRSDVLRIEYLYRRGRRQLQMLRSGHATAMGAFVRTRGPTEESNGAGAPGTLSGEGDDPRKPLDSMRTPKTPLDGR", "length": 118, "header": "sp|A8PU71-1|SDHF1_BOVIN Isoform 1 of Succinate dehydrogenase assembly factor 1, mitochondrial OS=Bos taurus OX=9913 GN=SDHAF1 PE=3 SV=1 CANONICAL=A8PU71-1" }, "isoforms": [ { "isoform_ac": "A8PU71-1", "url": "https://www.uniprot.org/uniprotkb/A8PU71/entry#A8PU71-1", "sequence": { "sequence": "MSRHSRLQRQVLSLYRELLRAGRGKPGAEARVRAEFRQHACLPRSDVLRIEYLYRRGRRQLQMLRSGHATAMGAFVRTRGPTEESNGAGAPGTLSGEGDDPRKPLDSMRTPKTPLDGR", "length": 118, "header": "sp|A8PU71-1|SDHF1_BOVIN Isoform 1 of Succinate dehydrogenase assembly factor 1, mitochondrial OS=Bos taurus OX=9913 GN=SDHAF1 PE=3 SV=1 CANONICAL=A8PU71-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:784051", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784051", "resource": "KEGG Pathway" }, { "id": "R-BTA-9854311", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9854311", "resource": "Reactome", "description": "Maturation of TCA enzymes and regulation of TCA cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A6NFY7-1", "protein_name": "Succinate dehydrogenase assembly factor 1, mitochondrial", "gene_name": "SDHAF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRHSRLQRQVLSLYRDLLRAGRGKPGAEARVRAEFRQHAGLPRSDVLRIEYLYRRGRRQLQLLRSGHATAMGAFVRPRAPTGEPGGVGCQPDDGDSPRNPHDSTGAPETRPDGR", "length": 115 }, "evidence": [ { "id": "A8PU71", "url": "https://omabrowser.org/oma/group/A8PU71/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "B0K036-1", "protein_name": "Succinate dehydrogenase assembly factor 1, mitochondrial", "gene_name": "Sdhaf1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRLSRLQRQVLSLYRELLRAGRGKPGAEARVRAEFRQHASLPRSDVLRIEYLYRRGRRQLQLLRSGHATAMGTFVRPRGPTEEPVDATAPGNRLDDSDALKNPCEGTGARETRSDGR", "length": 118 }, "evidence": [ { "id": "A8PU71", "url": "https://omabrowser.org/oma/group/A8PU71/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RLD9-1", "protein_name": "Succinate dehydrogenase complex assembly factor 1", "gene_name": "SDHAF1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSRHSRLQRQVLSLYRELLRAGRGKPGAEARVRAEFRQHACLPRSDVLRIEYLYRRGRRQLQLLRSGHATAMGAFVRTRDPTEESCGAEAPGTPPGEGPKRPLDSMGAPGTPSSER", "length": 116 }, "evidence": [ { "id": "A8PU71", "url": "https://omabrowser.org/oma/group/A8PU71/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3U276-1", "protein_name": "Succinate dehydrogenase assembly factor 1, mitochondrial", "gene_name": "Sdhaf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSRPSRLQRQVLSLYRELLRAGRGTPGAEARVRAEFRQHASLPRTDVLRIEYLYRRGRRQLQLLRSGHATAMGTFVRPRGPAEEPGDATAPGTRLDDGGAPKNSCEDTGARETRSDGR", "length": 118 }, "evidence": [ { "id": "A8PU71", "url": "https://omabrowser.org/oma/group/A8PU71/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A8PU71", "url": "https://www.uniprot.org/uniprotkb/A8PU71" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A8PU71", "url": "https://www.uniprot.org/uniprotkb/A8PU71" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial respiratory chain complex II assembly", "id": "GO:0034553", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034553", "evidence": [ { "database": "UniProtKB", "id": "A8PU71", "url": "https://www.uniprot.org/uniprotkb/A8PU71" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A8PU71-F1", "pdb_chain": 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"binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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{ "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A8QW39-1", "uniprot_ac": "A8QW39", "uniprot_id": "CF144_BOVIN", "mass": { "chemical_mass": 16146.0, "monoisotopic_mass": 16146.0 }, "refseq": { "ac": "NP_001103562", "name": "cilia- and flagella-associated protein 144", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103562" }, "gene_names": [ { "name": "CFAP144", "type": "recommended", "evidence": [ { "id": "A8QW39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A8QW39" } ] }, { "name": "CFAP144", "type": "synonym", "evidence": [ { "id": "NP_001103562", "database": "RefSeq", 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183 member A", "type": "synonym", "evidence": [ { "id": "NP_001103562", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103562" } ] }, { "name": "protein FAM183A", "type": "synonym", "evidence": [ { "id": "NP_001103562", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103562" } ] } ], "function": [ { "annotation": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.", "evidence": [ { "database": "UniProtKB", "id": "A8QW39", "url": "https://www.uniprot.org/uniprotkb/A8QW39#function" }, { "database": "UniProtKB", "id": "A6NL82", "url": "https://www.uniprot.org/uniprotkb/A6NL82#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A8QW39", "url": "https://www.uniprot.org/uniprotkb/A8QW39" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CFAP144", "url": "https://www.uniprot.org/uniprotkb/A8QW39", "locus": {} } ], "crossref": [ { "id": "A8QW39", "url": "https://alphafold.ebi.ac.uk/entry/A8QW39", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037555", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037555", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "782130", "url": "https://www.ncbi.nlm.nih.gov/gene/782130", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "8OTZ", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8OTZ&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9CPB", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9CPB&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR029214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782130", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782130", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SQEIGWM", "url": "https://omabrowser.org/oma/group/SQEIGWM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A8QW39", "url": "https://www.orthodb.org/?gene=A8QW39", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR33865", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33865", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33865:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33865:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00008otz", "url": "https://www.rcsb.org/structure/pdb_00008otz", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009cpb", "url": "https://www.rcsb.org/structure/pdb_00009cpb", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8OTZ", "url": "https://www.rcsb.org/structure/8OTZ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9CPB", "url": "https://www.rcsb.org/structure/9CPB", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF14886", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14886", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001103562", "url": 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"sp|A8QW39-1|CF144_BOVIN Isoform 1 of Cilia- and flagella-associated protein 144 OS=Bos taurus OX=9913 GN=CFAP144 PE=1 SV=1 CANONICAL=A8QW39-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structural specializations of the sperm tail.", "journal": "Cell", "date": "2023", "authors": "Leung Miguel Ricardo, Zeng Jianwei, Wang Xiangli, Roelofs Marc C, Huang Wei, Zenezini Chiozzi Riccardo, Hevler Johannes F, Heck Albert J R, Dutcher Susan K, Brown Alan, Zhang Rui, Zeev-Ben-Mordehai Tzviya", "evidence": [ { "database": "UniProtKB", "id": "A8QW39", "url": "https://www.uniprot.org/uniprotkb/A8QW39" } ], "reference": [ { "type": "PubMed", "id": "37327785", "url": "https://glygen.org/publication/PubMed/37327785" } ] } ], "pathway": [ { "id": "bta:782130", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782130", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3Z8P9-1", 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A8YXY3-1", "uniprot_ac": "A8YXY3", "uniprot_id": "SEP15_BOVIN", "mass": { "chemical_mass": 17975.0, "monoisotopic_mass": 17975.0 }, "refseq": { "ac": "NP_001029931", "name": "selenoprotein F precursor", "summary": "The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Nov 2016].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029931" }, "gene_names": [ { "name": "SELENOF", "type": "recommended", "evidence": [ { "id": "A8YXY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A8YXY3" } ] }, { "name": "SELENOF", "type": "synonym", "evidence": [ { "id": "NP_001029931", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029931" } ] }, { "name": "SEP15", "type": "synonym", "evidence": [ { "id": "NP_001029931", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029931" }, { "id": "A8YXY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A8YXY3" } ] } ], "protein_names": [ { "name": "Selenoprotein F", "type": "recommended", "evidence": [ { "id": "A8YXY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A8YXY3/entry#names_and_taxonomy" } ] }, { "name": "15 kDa selenoprotein", "type": "synonym", "evidence": [ { "id": "NP_001029931", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029931" } ] }, { "name": "selenoprotein F precursor", "type": "synonym", "evidence": [ { "id": "NP_001029931", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029931" } ] } ], "function": [ { "annotation": "May be involved in redox reactions associated with the formation of disulfide bonds (By similarity). May contribute to the quality control of protein folding in the endoplasmic reticulum. May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A8YXY3", "url": "https://www.uniprot.org/uniprotkb/A8YXY3#function" }, { "database": "UniProtKB", "id": "O60613", "url": "https://www.uniprot.org/uniprotkb/O60613#function" }, { "database": "UniProtKB", "id": "Q923V8", "url": "https://www.uniprot.org/uniprotkb/Q923V8#function" } ] }, { "annotation": "The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Nov 2016].", "evidence": [ { "database": "RefSeq", "id": "NP_001029931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029931" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A8YXY3", "url": "https://www.uniprot.org/uniprotkb/A8YXY3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SELENOF", "url": "https://www.uniprot.org/uniprotkb/A8YXY3", "locus": { "chromosome": "3", "start_pos": 57188980, "end_pos": 57145264, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000052268", "url": "https://www.ensembl.org/id/ENSBTAG00000052268" } ] } } ], "crossref": [ { "id": "ENSBTAG00000052268", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000052268", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614360", "url": "https://www.ncbi.nlm.nih.gov/gene/614360", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR014912", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014912", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614360", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614360", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IKPHCKQ", "url": "https://omabrowser.org/oma/group/IKPHCKQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A8YXY3", "url": "https://www.orthodb.org/?gene=A8YXY3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13077", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13077", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13077:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13077:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08806", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08806", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029931", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A8YXY3", "url": "https://www.uniprot.org/uniprotkb/A8YXY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A8YXY3-1", "url": "https://www.uniprot.org/uniprotkb/A8YXY3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAARRDGWLGPAFGLRLLLATVLQTVSALGAEFSSESCRELGFSSNLLCSSCDLLGQFNLLQLDPDCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQAFVRSDKPKLFKGLQIKYVRGSDPVLKLLDDSGNIAEELSILKWNTDSVEEFLSEKLERI", "length": 162, "header": "sp|A8YXY3-1|SEP15_BOVIN Isoform 1 of Selenoprotein F OS=Bos taurus OX=9913 GN=SELENOF PE=2 SV=2 CANONICAL=A8YXY3-1" }, "isoforms": [ { "isoform_ac": "A8YXY3-1", "url": "https://www.uniprot.org/uniprotkb/A8YXY3/entry#A8YXY3-1", "sequence": { "sequence": "MAARRDGWLGPAFGLRLLLATVLQTVSALGAEFSSESCRELGFSSNLLCSSCDLLGQFNLLQLDPDCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQAFVRSDKPKLFKGLQIKYVRGSDPVLKLLDDSGNIAEELSILKWNTDSVEEFLSEKLERI", "length": 162, "header": "sp|A8YXY3-1|SEP15_BOVIN Isoform 1 of Selenoprotein F OS=Bos taurus OX=9913 GN=SELENOF PE=2 SV=2 CANONICAL=A8YXY3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614360", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614360", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A1Z623-1", "protein_name": "Selenoprotein F", "gene_name": "SELENOF", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAEPGGWLGPALGLRLLLATALQMVSAFGAEFSSESCRELGFSSNLLCGSCDLLGQFDLLQLDPDCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQAFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLQRV", "length": 162 }, "evidence": [ { "id": "A8YXY3", "url": "https://omabrowser.org/oma/group/A8YXY3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O60613-1", "protein_name": "Selenoprotein F", "gene_name": "SELENOF", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVAMAAGPSGCLVPAFGLRLLLATVLQAVSAFGAEFSSEACRELGFSSNLLCSSCDLLGQFNLLQLDPDCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQAFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLERI", "length": 165 }, "evidence": [ { "id": "A8YXY3", "url": "https://omabrowser.org/oma/group/A8YXY3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q55FV9-1", "protein_name": "Selenoprotein F", "gene_name": "sep15", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MHIDKKIKRPPNRWSLIFLLAAIFLCILINDCQGVSSPGTSASSCHELGFTDALLCSTCKDFAEFVGDSAFGHECSICCSEESEKVKKTYQSVSLVVCQURLGAHPQIKEFINNKAKLYSKLSVKYENGANPRLTLVDSEGKKEDINIESWKLENLEEYLVQNNFN", "length": 166 }, "evidence": [ { "id": "A8YXY3", "url": "https://omabrowser.org/oma/group/A8YXY3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q802F3-1", "protein_name": "Selenoprotein F", "gene_name": "selenof", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAGEVYLLWLLPLLQGLASYGAELSSEACRELGFSSNLLCSSCELLGQFSLNQLDLPCRQCCQEEAQLENRKLYPGAILEVCGUKLGRFPQVQAFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLERI", "length": 153 }, "evidence": [ { "id": "A8YXY3", "url": "https://omabrowser.org/oma/group/A8YXY3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q923V8-1", "protein_name": "Selenoprotein F", "gene_name": "Selenof", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAGQGGWLRPALGLRLLLATAFQAVSALGAEFSSEACRELGFSSNLLCSSCDLLGQFNLLPLDPVCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQAFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLERI", "length": 162 }, "evidence": [ { "id": "A8YXY3", "url": "https://omabrowser.org/oma/group/A8YXY3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9ERR7-1", "protein_name": "Selenoprotein F", "gene_name": "Selenof", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAGQGGWLRPALGLRLLLATAFQAVSALGAEFASEACRELGFSSNLLCSSCDLLGQFNLLPLDPVCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQAFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLERI", "length": 162 }, "evidence": [ { "id": "A8YXY3", "url": "https://omabrowser.org/oma/group/A8YXY3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VVJ7-1", "protein_name": "Selenoprotein F", "gene_name": "Sep15", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MHKCAIFLLLALSCQQIQAELTAADCRALGFIKAQLMCSSCEKLDDFGLDTIKPQCKQCCTLDQQPAAQRTYAKAILEVCTCKFRAYPQIQAFIQSGRPAKFPNLQIKYVRGLDPVVKLLDASGKVQETLSITKWNTDTVEEFFETHLAKDGAGKNSYSVVEDADGDDDEDYLRTNRI", "length": 178 }, "evidence": [ { "id": "A8YXY3", "url": "https://omabrowser.org/oma/group/A8YXY3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "A8YXY3", "url": "https://www.uniprot.org/uniprotkb/A8YXY3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "A8YXY3", "url": "https://www.uniprot.org/uniprotkb/A8YXY3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "'de novo' post-translational protein folding", "id": "GO:0051084", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051084", "evidence": [ { "database": "UniProtKB", "id": "A8YXY3", "url": "https://www.uniprot.org/uniprotkb/A8YXY3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A9Q1J7" } ] }, { "name": "STELLA", "type": "synonym", "evidence": [ { "id": "A9Q1J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A9Q1J7" } ] } ], "protein_names": [ { "name": "Developmental pluripotency-associated protein 3", "type": "recommended", "evidence": [ { "id": "A9Q1J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A9Q1J7/entry#names_and_taxonomy" } ] }, { "name": "Stella-related protein", "type": "synonym", "evidence": [ { "id": "A9Q1J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A9Q1J7/entry#names_and_taxonomy" } ] }, { "name": "developmental pluripotency-associated protein 3 isoform 2", "type": "synonym", "evidence": [ { "id": "NP_001104578", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104578" } ] }, { "name": "developmental pluripotency-associated protein 3", "type": "synonym", "evidence": [ { "id": "NP_001104578", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104578" } ] }, { "name": "stella-related protein", "type": "synonym", "evidence": [ { "id": "NP_001104578", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104578" } ] }, { "name": "stella", "type": "synonym", "evidence": [ { "id": "NP_001104578", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104578" } ] } ], "function": [ { "annotation": "DPPA3 is a maternal factor important for correct epigenetic remodeling and normal embryonic development in cattle, indicating that the role of DPPA3 during early development is conserved between species.", "evidence": [ { "database": "RefSeq", "id": "NP_001104578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104578" }, { "database": "PubMed", "id": "25147917", "url": "https://glygen.org/publication/PubMed/25147917" } ] }, { "annotation": "Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis.", "evidence": [ { "database": "UniProtKB", "id": "A9Q1J7", "url": "https://www.uniprot.org/uniprotkb/A9Q1J7#function" }, { "database": "UniProtKB", "id": "Q8QZY3", "url": "https://www.uniprot.org/uniprotkb/Q8QZY3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A9Q1J7", "url": "https://www.uniprot.org/uniprotkb/A9Q1J7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DPPA3", "url": "https://www.uniprot.org/uniprotkb/A9Q1J7", "locus": { "chromosome": "5", "start_pos": 101341323, "end_pos": 101333531, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046609", "url": "https://www.ensembl.org/id/ENSBTAG00000046609" } ] } } ], "crossref": [ { "id": "A9Q1J7", "url": "https://alphafold.ebi.ac.uk/entry/A9Q1J7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046609", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046609", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616433", "url": "https://www.ncbi.nlm.nih.gov/gene/616433", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616433", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616433", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RFRCSCH", "url": "https://omabrowser.org/oma/group/RFRCSCH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A9Q1J7", "url": "https://www.orthodb.org/?gene=A9Q1J7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31577", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31577", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31577:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31577:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15549", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15549", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001104578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104578", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A9Q1J7", "url": "https://www.uniprot.org/uniprotkb/A9Q1J7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A9Q1J7-1", "url": "https://www.uniprot.org/uniprotkb/A9Q1J7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSSEDNPTWTLESLKTSIDDASQAMQVATQLSEMLATNLSNLTLNPSIKLPYLPEYPSQLTGQLPSEKTPHRRRGVRTVLSERRYRMQKLIESLRLRYAKGIPRSDSQRQLQQQEDTEIRSRVRRFQCTCSYCQFKRNPSDDNYENYYNTTYSNYAMESNES", "length": 163, "header": "sp|A9Q1J7-1|DPPA3_BOVIN Isoform 1 of Developmental pluripotency-associated protein 3 OS=Bos taurus OX=9913 GN=DPPA3 PE=2 SV=1 CANONICAL=A9Q1J7-1" }, "isoforms": [ { "isoform_ac": "A9Q1J7-1", "url": "https://www.uniprot.org/uniprotkb/A9Q1J7/entry#A9Q1J7-1", "sequence": { "sequence": "MDSSEDNPTWTLESLKTSIDDASQAMQVATQLSEMLATNLSNLTLNPSIKLPYLPEYPSQLTGQLPSEKTPHRRRGVRTVLSERRYRMQKLIESLRLRYAKGIPRSDSQRQLQQQEDTEIRSRVRRFQCTCSYCQFKRNPSDDNYENYYNTTYSNYAMESNES", "length": 163, "header": "sp|A9Q1J7-1|DPPA3_BOVIN Isoform 1 of Developmental pluripotency-associated protein 3 OS=Bos taurus OX=9913 GN=DPPA3 PE=2 SV=1 CANONICAL=A9Q1J7-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Differential regulation of abundance and deadenylation of maternal transcripts during bovine oocyte maturation in vitro and in vivo.", "journal": "BMC Dev. Biol.", "date": "2007", "authors": "Th\u00e9lie Aurore, Papillier Pascal, Pennetier Sophie, Perreau Christine, Traverso Juan Martin, Uzbekova Svetlana, Mermillod Pascal, Joly Catherine, Humblot Patrice, Dalbi\u00e8s-Tran Rozenn", "evidence": [ { "database": "UniProtKB", "id": "A9Q1J7", "url": "https://www.uniprot.org/uniprotkb/A9Q1J7" } ], "reference": [ { "type": "PubMed", "id": "17988387", "url": "https://glygen.org/publication/PubMed/17988387" } ] }, { "title": "A whole-genome assembly of the domestic cow, Bos taurus.", "journal": "Genome Biol.", "date": "2009", "authors": "Zimin Aleksey V, Delcher Arthur L, Florea Liliana, Kelley David R, Schatz Michael C, Puiu Daniela, Hanrahan Finnian, Pertea Geo, Van Tassell Curtis P, Sonstegard Tad S, Mar\u00e7ais Guillaume, Roberts Michael, Subramanian Poorani, Yorke James A, Salzberg Steven L", "evidence": [ { "database": "UniProtKB", "id": "A9Q1J7", "url": "https://www.uniprot.org/uniprotkb/A9Q1J7" } ], "reference": [ { "type": "PubMed", "id": "19393038", "url": "https://glygen.org/publication/PubMed/19393038" } ] }, { "title": "DPPA3 prevents cytosine hydroxymethylation of the maternal pronucleus and is required for normal development in bovine embryos.", "journal": "Epigenetics", "date": "2014-09", "authors": "Bakhtari Azizollah, Ross Pablo J", "evidence": [ { "database": "RefSeq", "id": "NP_001104578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104578" } ], "reference": [ { "type": "PubMed", "id": "25147917", "url": "https://glygen.org/publication/PubMed/25147917" } ] } ], "pathway": [ { "id": "bta:616433", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616433", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A9Q1J7", "url": 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{ "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "C0LMH8-1", "uniprot_ac": "C0LMH8", "uniprot_id": "C0LMH8_BOVIN", "mass": { "chemical_mass": 48685.0, "monoisotopic_mass": 48685.0 }, "refseq": { "ac": "NP_001139464", "name": "carbohydrate sulfotransferase 8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139464" }, "gene_names": [ { "name": "CHST8", "type": "recommended", "evidence": [ { "id": "C0LMH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/C0LMH8" } ] }, { "name": "CHST8", "type": "synonym", "evidence": [ { "id": "NP_001139464", "database": "RefSeq", "url": 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and healthy cows indicate an association of sequence variant g.37254017G>T of CHST8 with the development of the disease in Brown Swiss cattle.", "evidence": [ { "database": "RefSeq", "id": "NP_001139464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139464" }, { "database": "PubMed", "id": "19744145", "url": "https://glygen.org/publication/PubMed/19744145" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "C0LMH8", "url": "https://www.uniprot.org/uniprotkb/C0LMH8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHST8", "url": "https://www.uniprot.org/uniprotkb/C0LMH8", "locus": { "chromosome": "18", "start_pos": 44178263, "end_pos": 44033076, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047670", "url": "https://www.ensembl.org/id/ENSBTAG00000047670" } ] } } ], "crossref": [ { "id": "ENSBTAG00000047670", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047670", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100271926", "url": "https://www.ncbi.nlm.nih.gov/gene/100271926", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100271926", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100271926", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HIIAHDD", "url": "https://omabrowser.org/oma/group/HIIAHDD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "C0LMH8", "url": "https://www.orthodb.org/?gene=C0LMH8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12137", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12137", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12137:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12137:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03567", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03567", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-975578", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975578", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001139464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139464", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "C0LMH8", "url": "https://www.uniprot.org/uniprotkb/C0LMH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C0LMH8-1", "url": "https://www.uniprot.org/uniprotkb/C0LMH8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPRAGTMRLACMFSSILLFGAAGLLLFISLQDPTELTPHQAPGIKFSIRPQQPHNDLPPGSSQDGPFKAATERVTRDLSSRAPRGLSLRMSQDPQAQLNVGARLRPRQRRRRLLIKKMPAAAALPANSSAGTLARPAPGALDGRWARLRETQRERKRVMREACAKYRASSSRRAVTPRHVSRIFVEDRHRVLYCEVPKAGCSNWKRVLMVLAGLASSTTDIQHDTVHYGSALKRLDTFDRQGILHRLGTYTKMLFVREPFERLVSAFRDKFEHPNSYYHPVFGKAILARYRANASREALRTGSGVRFPEFVQYLLDVHRPVGMDIHWDHVSRLCSPCLIDYDFVGKFESMEDDANFFLSLIHAPRNLTFPRFKDRHSEEARTTSRITHQYFAQLSTLQRQRTYDFYYMDYLMFNYSKPFADLY", "length": 424, "header": "tr|C0LMH8-1|C0LMH8_BOVIN Isoform 1 of Carbohydrate sulfotransferase OS=Bos taurus OX=9913 GN=CHST8 PE=3 SV=1 CANONICAL=C0LMH8-1" }, "isoforms": [ { "isoform_ac": "C0LMH8-1", "url": "https://www.uniprot.org/uniprotkb/C0LMH8/entry#C0LMH8-1", "sequence": { "sequence": "MSPRAGTMRLACMFSSILLFGAAGLLLFISLQDPTELTPHQAPGIKFSIRPQQPHNDLPPGSSQDGPFKAATERVTRDLSSRAPRGLSLRMSQDPQAQLNVGARLRPRQRRRRLLIKKMPAAAALPANSSAGTLARPAPGALDGRWARLRETQRERKRVMREACAKYRASSSRRAVTPRHVSRIFVEDRHRVLYCEVPKAGCSNWKRVLMVLAGLASSTTDIQHDTVHYGSALKRLDTFDRQGILHRLGTYTKMLFVREPFERLVSAFRDKFEHPNSYYHPVFGKAILARYRANASREALRTGSGVRFPEFVQYLLDVHRPVGMDIHWDHVSRLCSPCLIDYDFVGKFESMEDDANFFLSLIHAPRNLTFPRFKDRHSEEARTTSRITHQYFAQLSTLQRQRTYDFYYMDYLMFNYSKPFADLY", "length": 424, "header": "tr|C0LMH8-1|C0LMH8_BOVIN Isoform 1 of Carbohydrate sulfotransferase OS=Bos taurus OX=9913 GN=CHST8 PE=3 SV=1 CANONICAL=C0LMH8-1" }, "locus": { "chromosome": "18", "start_pos": 44177800, "end_pos": 44104449, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064164.4", "url": "https://www.ensembl.org/id/ENSBTAT00000064164.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056551.1", "url": "https://www.ensembl.org/id/ENSBTAP00000056551.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 177, "start_aa": "Thr", "end_pos": 177, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr177", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Molecular analysis of carbohydrate N-acetylgalactosamine 4-O sulfotransferase 8 (CHST8) as a candidate gene for bovine spongiform encephalopathy susceptibility.", "journal": "Animal genetics", "date": "2010-02", "authors": "Morina R, Knorr C, Haase B, Leeb T, Seuberlich T, Zurbriggen A, Brem G, Sch\u00fctz E, Brenig B", "evidence": [ { "database": "RefSeq", "id": "NP_001139464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139464" } ], "reference": [ { "type": "PubMed", "id": "19744145", "url": "https://glygen.org/publication/PubMed/19744145" } ] } ], "pathway": [ { "id": "bta:100271926", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100271926", "resource": "KEGG Pathway" }, { "id": "R-BTA-975578", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975578", "resource": "Reactome", "description": "Reactions specific to the complex N-glycan synthesis pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZI43-1", "protein_name": "Carbohydrate sulfotransferase", "gene_name": "CHST8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPQRPGTMRLACMFSSILLFGAAGLLLFISLQDPTELAPQQVPGIKFNIRPQQPHNDLPPGSSQDGDLKAPTERVIRDWSSQTSRGLNPQVPEQPPAHLNVGARLRPRQRRRRLLIKKMPAAASLAANNSAATLVLPAHRALDGRWVSLHQSQQERKRVMREACAKYRASSSRRAVTPRHVSRIFVEDRHRVLYCEVPKAGCSNWKRVLMVLAGLASSTTDIQHNTVHYGSALKRLDTFDRQGILHRLSTYTKMLFVREPFERLVSAFRDKFEHPNSYYHPVFGKAILARYRANASREALRTGSGVRFPEFVQYLLDVHRPVGMDIHWDHVSRLCSPCLIDYDFVGKFESMEDDANFFLSLIQAPRNLTFPRFKDRHSQEARTTARITHQYFAQLSTLQRQRTYDFYYMDYLMFNYSKPFADLY", "length": 424 }, "evidence": [ { "id": "C0LMH8", "url": "https://omabrowser.org/oma/group/C0LMH8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8BQ86-1", "protein_name": "Carbohydrate sulfotransferase 8", "gene_name": "Chst8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTPRLGTMRLACMFSSILLFGAAGLLLFISLQDPIELSPQQVPGIKFSIRPQQPQHDSHLRISTEKGTRDSPSGSPRGLQLQAPDQPRPHPKAAGSPLRLRQRRRRLLIKKMPAAGTNQGNNSSETFIQPRPRTMDSRWVSLHQTQQERKRVMREACAKYRASSSRRAVTPRHVSRIFVEDRHRVLYCEVPKAGCSNWKRVLMVLAGLASSTADIQHNTVHYGSALKRLDTFDRQGIVHRLSTYTKMLFVREPFERLVSAFRDKFEHPNSYYHPVFGKAILARYRANASREALRTGSGVQFPEFVQYLLDVHRPVGMDIHWDHVSRLCSPCLIDYDFVGKFESMEDDANFFLRLIHAPGNLTFPRFKDRHSEEARTTSRITHQYFAQLSSLQRQRTYDFYYMDYLMFNYSKPFSDLY", "length": 417 }, "evidence": [ { "id": "C0LMH8", "url": "https://omabrowser.org/oma/group/C0LMH8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "sulfotransferase activity", "id": "GO:0008146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008146", "evidence": [ { "database": "UniProtKB", "id": "C0LMH8", "url": "https://www.uniprot.org/uniprotkb/C0LMH8" } ], "pmid": "" }, { "name": "dermatan 4-sulfotransferase activity", "id": "GO:0001537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001537", "evidence": [ { "database": "UniProtKB", "id": "C0LMH8", "url": "https://www.uniprot.org/uniprotkb/C0LMH8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "carbohydrate biosynthetic process", "id": "GO:0016051", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016051", "evidence": [ { "database": "UniProtKB", "id": "C0LMH8", "url": "https://www.uniprot.org/uniprotkb/C0LMH8" } ], "pmid": "" }, { "name": "hormone biosynthetic process", "id": "GO:0042446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042446", "evidence": [ { "database": "UniProtKB", "id": "C0LMH8", "url": "https://www.uniprot.org/uniprotkb/C0LMH8" } ], "pmid": "" }, { "name": "sulfur compound metabolic process", "id": "GO:0006790", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006790", "evidence": [ { "database": "UniProtKB", "id": "C0LMH8", "url": "https://www.uniprot.org/uniprotkb/C0LMH8" } ], "pmid": "" }, { "name": "proteoglycan biosynthetic process", "id": "GO:0030166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030166", "evidence": [ { "database": "UniProtKB", "id": "C0LMH8", "url": "https://www.uniprot.org/uniprotkb/C0LMH8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "C0LMH8", "url": "https://www.uniprot.org/uniprotkb/C0LMH8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 294, "end_pos": 296, "annotation": "n_glycosylation_sequon" }, { "start_pos": 367, "end_pos": 369, "annotation": "n_glycosylation_sequon" }, { "start_pos": 415, "end_pos": 417, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-6786034", "name": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "C0LMH8-1" ], "evidence": [ { "id": "R-BTA-6786034", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6786034" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "C0LMH8", "gene_name": "CHST8", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "C0LMH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/C0LMH8" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [ { "glytoucan_ac": "G00017IP", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G00230CO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G00582VL", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G00636QL", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G00740UU", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G02057LB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G04846SY", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G04893EC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G05151WT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G05377HJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G05611SB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G06216UH", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G07123BN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G08009LH", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G08070PH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G08627LE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G10235QZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G12243WN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G13849RQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G14281OH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G14695KF", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G15688CE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G15719NX", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G16058FI", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G16230QU", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G16316CS", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G16402DK", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G16943PO", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G17107VB", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G17344FG", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G18640IS", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G18806VU", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G19106CR", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G21495CG", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G21519PO", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G21695CC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G22406UE", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G23408TM", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G23614TN", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G23647WB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G24413UY", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G24812WY", "type": "N-linked", 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"go_terms": [ { "name": "protein-cysteine S-palmitoyltransferase activity", "id": "GO:0019706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019706", "evidence": [ { "database": "UniProtKB", "id": "E1B6X9", "url": "https://www.uniprot.org/uniprotkb/E1B6X9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "36683", "name": "", "equation": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3X756-1", "E1BPA5-1", "F1MVC6-1", "E1B987-1", "E1BJK1-1", "F6R785-1", "A0AAA9TDW4-1", "A0AAA9TVJ9-1", "A0AAA9TM40-1", "E1B6X9-1", "E1BKA0-1", "E1BK60-1", "Q58CU4-1", "A2VDT6-1", "A0AAF6ZH94-1", "A0AAA9RZ07-1", "Q0VC89-1", "E1BLT8-1", "G3MXF3-1", "P15103-1", "Q2HJ95-1", "Q58DA8-1", "A0A3Q1M794-1", "A0A3Q1LVW6-1", "Q58DT3-1", "A0A3Q1M403-1", "A0ABI0NXA5-1" ], "evidence": [ { "id": "36683", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36683" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LVW6", "gene_name": "ZDHHC13", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0A3Q1LVW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0A3Q1LVW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6" } ] } ] }, { "uniprot_ac": "A0A3Q1M403", "gene_name": "", "activity": [ { "ec_number": "6.3.1.2", "activity": "L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] }, { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] }, { "ec_number": "6.3.1.2", "activity": "", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] } ] }, { "uniprot_ac": "A0A3Q1M794", "gene_name": "ZDHHC3", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0A3Q1M794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M794" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0A3Q1M794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M794" } ] } ] }, { "uniprot_ac": "A0AAA9RZ07", "gene_name": "ZDHHC8", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9RZ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ07" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9RZ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ07" } ] } ] }, { "uniprot_ac": "A0AAA9TDW4", "gene_name": "ZDHHC7", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9TDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW4" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9TDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW4" } ] } ] }, { "uniprot_ac": "A0AAA9TM40", "gene_name": "ZDHHC18", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9TM40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM40" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9TM40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM40" } ] } ] }, { "uniprot_ac": "A0AAA9TVJ9", "gene_name": "ZDHHC23", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9TVJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVJ9" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9TVJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVJ9" } ] } ] }, { "uniprot_ac": "A0AAF6ZH94", "gene_name": "ZDHHC9", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAF6ZH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAF6ZH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ] } ] }, { "uniprot_ac": "A0ABI0NXA5", "gene_name": "ZDHHC15", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0ABI0NXA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXA5" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0ABI0NXA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXA5" } ] } ] }, { "uniprot_ac": "A2VDT6", "gene_name": "ZDHHC21", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A2VDT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT6" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A2VDT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT6" } ] } ] }, { "uniprot_ac": "E1B6X9", "gene_name": "ZDHHC12", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1B6X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X9" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1B6X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X9" } ] } ] }, { "uniprot_ac": "E1B987", "gene_name": "ZDHHC22", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1B987", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B987" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1B987", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B987" } ] } ] }, { "uniprot_ac": "E1BJK1", "gene_name": "ZDHHC17", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1BJK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJK1" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ 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"uniprot_ac": "F1MVC6", "gene_name": "", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "F1MVC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVC6" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "F1MVC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVC6" } ] } ] }, { "uniprot_ac": "F6R785", "gene_name": "ZDHHC1", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "F6R785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R785" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "F6R785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R785" } ] } ] }, { "uniprot_ac": "G3MXF3", "gene_name": "ZDHHC2", "activity": [ { 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Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. 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"id": "E1B6Y9", "url": "https://alphafold.ebi.ac.uk/entry/E1B6Y9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001912", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001912", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22192", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22192", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22296", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22296", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "524365", "url": "https://www.ncbi.nlm.nih.gov/gene/524365", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008344", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008344", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008346", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008346", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024862", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024862", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524365", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524365", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AYETHED", "url": "https://omabrowser.org/oma/group/AYETHED/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B6Y9", "url": "https://www.orthodb.org/?gene=E1B6Y9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10582", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10582", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10582:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10582:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3295583", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3295583", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010802928", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802928", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29671", "url": "https://www.rhea-db.org/rhea/29671", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1B6Y9", "url": "https://www.uniprot.org/uniprotkb/E1B6Y9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B6Y9-1", "url": "https://www.uniprot.org/uniprotkb/E1B6Y9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAPPSKARGLWIQLQKLLTSWLVGQQDWDQRLDEMYMLQQQKIRESPLLRAAKDNDLCVLKKLLLDRNCDFRQRGAVGETALHVAALYDNLEAAMVLMEAAPELVKEPAICEPFVGQTALHIAVMNRNVNLVKALLAQGASVSARAIGSAFRLTPHNLIYFGEHPLSFAACMGSEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYNLLLSYDRRGDHLQSLDLMLNHQGLTPFKLAGVEGNTVMFQHLMQKRKYIQWTCGPLTSTLYDLTEIDSWGEDVSFLELVVSSKKREARQILEQTPVKQLVNFKWRKYGRPYFCILGALYVLYMICFTMCCIHRPLKARSGNRTDSRDITVFQQKLLQEAYVTQQDKIRLVGELMTVIGSAIILFLEIPDIFRVGFSRYFGQTVLGGPFHVITITYSFLVLVTMVMRLTNTSGEVVPMSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLLRFCWLMAVVIVGFASAFYIIFQTEDPSALGEFYDYPMALFSTFELFLTIIDGPANYDVDLPFMYSIVYFAFAIIATLLMINLLVAMMGDTHWRVAHEQDELWRAQVVATTVMLERKMPRTLWPRSGICGYKYGLGDRWFLRVETNQDQNTLRARRYVEAFKGSDKEEGQGHPPEKRPSVTESGLLARASLALPTPSLSRTTSRSSGSHRGWEIIRRNTLGHVNLGLDLGEGDGDDRVYQL", "length": 731, "header": "tr|E1B6Y9-1|E1B6Y9_BOVIN Isoform 1 of Transient receptor potential cation channel subfamily V member 5 OS=Bos taurus OX=9913 GN=TRPV5 PE=3 SV=2 CANONICAL=E1B6Y9-1" }, "isoforms": [ { "isoform_ac": "E1B6Y9-1", "url": "https://www.uniprot.org/uniprotkb/E1B6Y9/entry#E1B6Y9-1", "sequence": { "sequence": "MGAPPSKARGLWIQLQKLLTSWLVGQQDWDQRLDEMYMLQQQKIRESPLLRAAKDNDLCVLKKLLLDRNCDFRQRGAVGETALHVAALYDNLEAAMVLMEAAPELVKEPAICEPFVGQTALHIAVMNRNVNLVKALLAQGASVSARAIGSAFRLTPHNLIYFGEHPLSFAACMGSEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYNLLLSYDRRGDHLQSLDLMLNHQGLTPFKLAGVEGNTVMFQHLMQKRKYIQWTCGPLTSTLYDLTEIDSWGEDVSFLELVVSSKKREARQILEQTPVKQLVNFKWRKYGRPYFCILGALYVLYMICFTMCCIHRPLKARSGNRTDSRDITVFQQKLLQEAYVTQQDKIRLVGELMTVIGSAIILFLEIPDIFRVGFSRYFGQTVLGGPFHVITITYSFLVLVTMVMRLTNTSGEVVPMSFALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLLRFCWLMAVVIVGFASAFYIIFQTEDPSALGEFYDYPMALFSTFELFLTIIDGPANYDVDLPFMYSIVYFAFAIIATLLMINLLVAMMGDTHWRVAHEQDELWRAQVVATTVMLERKMPRTLWPRSGICGYKYGLGDRWFLRVETNQDQNTLRARRYVEAFKGSDKEEGQGHPPEKRPSVTESGLLARASLALPTPSLSRTTSRSSGSHRGWEIIRRNTLGHVNLGLDLGEGDGDDRVYQL", "length": 731, "header": "tr|E1B6Y9-1|E1B6Y9_BOVIN Isoform 1 of Transient receptor potential cation channel subfamily V member 5 OS=Bos taurus OX=9913 GN=TRPV5 PE=3 SV=2 CANONICAL=E1B6Y9-1" }, "locus": { "chromosome": "4", "start_pos": 106246263, "end_pos": 106215589, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002485.5", "url": "https://www.ensembl.org/id/ENSBTAT00000002485.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002485.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002485.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 685, "start_aa": "Thr", "end_pos": 685, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr685", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:524365", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524365", "resource": "KEGG Pathway" }, { "id": "R-BTA-3295583", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3295583", "resource": "Reactome", "description": "TRP channels" } ], "orthologs": [ { "uniprot_canonical_ac": "F1QN56-1", "protein_name": "Transient receptor potential cation channel subfamily V member 6 isoform X1", "gene_name": "trpv6", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPPAISGEINHWWRQMRFRLQHKKGWNEMLDETFLMQTKRVNDIPLFSATKENNAACIKKLLDCSSTDIFERGELGETALHVAVMNDNFEAAVALMNGAPELINEPMTSELYHGLTALHIAVINQNPNLIWEMIKRGADVTTPRVTGMYFRKRREGLFYYGEHILAFAACVGNKDIMSMLIKAGANIRAQDSRGNTILHLLVLQPNKTTACQIFDFLLAQDAEQDSALPLDMVPNYKGLTPFKLAARDGNVVVFQHLVNRRKVVQWSLGPVSSYLYDLTEIDSRVDEHSVLEIIATSHKKEARRILELTPVRQLITLKWNLYGKHYFRSLMVIYLVYISIFTVCCINRPLKGIPENYTKAGNDHTIKIKKTFKESYQSYTDQLRLIAEIISLIGAIIILLIEIPGILAVGVKRFFGQTALGGLFHVTLISYALLVLLLCGLRVTGIQGELIPMAFSLILGWFSLVYFARGFEMLGPYVIVIQKSIFGDITKFMWLSIIFLIGSSAALWIFYMTQEPLALPQYRSFPITLFSQFEVSVGQIDLPVDHTLFTHPVVYWTHVCFSLISNVLLFNLLVAMMSDTQWRVTQERDELWRTQVVATTLMLERKLPQCLWPRLGVCGLMFGLGERWYLRVEDRNDIMAQKLKRYVDAFSKDVEAPKEEKPSKSDGEQSIAESNKEKSKKSKQYWSLIRRSIECEKEECVDCPNFKFL", "length": 709 }, "evidence": [ { "id": "E1B6Y9", "url": "https://omabrowser.org/oma/group/E1B6Y9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P69744-1", "protein_name": "Transient receptor potential cation channel subfamily V member 5", "gene_name": "Trpv5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGAKTPWIQLQKLLNWWVRDQDWNQHVDQLHMLQQKSIWESPLLRAAKENDMCTLKKLQHDQNCDFRQRGALGETALHVAALYDNLDAAIMLMEAAPYLVTESTLCEPFVGQTALHIAVMNQNVNLVRALLARGASASARATGSAFHRSSHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYNLLLSYDGGDHLKSLELVPNNQGLTPFKLAGVEGNTVMFQHLMQKRKRIQWSFGPLTSSLYDLTEIDSWGEELSFLELVVSSKKKEARQILEQTPVKELVSLKWKKYGQPYFCLLGALYIFYMVCFTTCCVYRPLKFRDANRTHVRDNTIMEQKSLQEAYVTYQDKIRLVGELVTVIGAVIILLLEIPDIFRVGASRYFGQTVLGGPFHVIIITYASLVLLTMAMRLTNVNGEVVPMSMALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLLRFCWLMAMVILGFASAFYIIFQTEDPDNLGEFSDYPTAMFSTFELFLTIIDGPANYRVDLPFMYSVTYATFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWPRSGICGCEYGLGDRWFLRVEHHQEQNPYRVLRYVEAFKSSDKEEVQEQLSEKQPSGTETGTLARGSVVLQTPPLSRTTSLSSNSHRGWEILRRNTLGHLNLGLDPGEGDGEEIYQF", "length": 723 }, "evidence": [ { "id": "E1B6Y9", "url": "https://omabrowser.org/oma/group/E1B6Y9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9JIP0-1", "protein_name": "Transient receptor potential cation channel subfamily V member 5", "gene_name": "Trpv5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGVKKPWIQLQKRLNWWVREQDWNQHVDQLHMLQQKSIWESPLLRAAKENDMCTLKRLQHDQNCDFRQRGALGETALHVAALYDNLDAAIMLMETAPYLVTESTLCEPFVGQTALHIAIMNQNVNLVRALLARGASASARATGSAFHRSSHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYNLLLSHDGGDHLKSLELVPNNQGLTPFKLAGVEGNTVMFQHLMQKRKHIQWSLGPLTSSIYDLTEIDSWGEDLSFLELVVSSKKKEARQILEQTPVKELVSLKWKKYGQPYFCLLGMLYIFYMICFTTCCVYRPLKFRDANRTHVRDNTVLEQKPLQEAYVTYQDKVRLVGELVTVIGAVVILLIEIPDIFRVGASRYFGHTVLGGPFHVIIITYASLVLLIMVMRLTSMNGEVVPISMALVLGWCSVMYFSRGFQMLGPFTIMIQKMIFGDLLRFCWLMAMVILGFASAFYIIFQTEDPESLGEFSDYPTAMFSTFELFLTIIDGPANYSVDLPFMYHLTYFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWPRSGICGCEYGLGDRWFLRVEHHQEQNPYRVLRYVEAFKSSDKEEVQEQLSEKQPSGTETGTLARGSVVLQTPPLSRTTSLSSNSHRGWEILRRNTLGHLNLGQDLGEGDGEEIYHF", "length": 723 }, "evidence": [ { "id": "E1B6Y9", "url": "https://omabrowser.org/oma/group/E1B6Y9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NQA5-1", "protein_name": "Transient receptor potential cation channel subfamily V member 5", "gene_name": "TRPV5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRHSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTVIDAPANYDVDLPFMFSIVNFAFTIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQEHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTLGHLNLGLNLSEGDGEEVYHF", "length": 729 }, "evidence": [ { "id": "E1B6Y9", "url": "https://omabrowser.org/oma/group/E1B6Y9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "calcium channel activity", "id": "GO:0005262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005262", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y9", "url": "https://www.uniprot.org/uniprotkb/E1B6Y9" } ], "pmid": "" }, { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y9", "url": "https://www.uniprot.org/uniprotkb/E1B6Y9" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y9", "url": "https://www.uniprot.org/uniprotkb/E1B6Y9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y9", "url": "https://www.uniprot.org/uniprotkb/E1B6Y9" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y9", "url": "https://www.uniprot.org/uniprotkb/E1B6Y9" } ], "pmid": "" }, { "name": "calcium channel complex", "id": "GO:0034704", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034704", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y9", "url": "https://www.uniprot.org/uniprotkb/E1B6Y9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of urine volume", "id": "GO:0035809", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035809", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y9", "url": "https://www.uniprot.org/uniprotkb/E1B6Y9" } ], "pmid": "" }, { "name": "calcium ion homeostasis", "id": "GO:0055074", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055074", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y9", "url": "https://www.uniprot.org/uniprotkb/E1B6Y9" } ], "pmid": "" }, { "name": "calcium ion import across plasma membrane", "id": "GO:0098703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098703", "evidence": [ { "database": "UniProtKB", "id": "E1B6Y9", "url": "https://www.uniprot.org/uniprotkb/E1B6Y9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" }, { "start_pos": 358, "end_pos": 360, "annotation": "n_glycosylation_sequon" }, { "start_pos": 446, "end_pos": 448, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29671", "name": "", "equation": "Ca(2+)(in) = Ca(2+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MPF0-1", "A0AAA9RSQ6-1" ], "evidence": [ { "id": "29671", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29671" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B6Y9-F1", "pdb_chain": "global", 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"start_pos": 10140041, "end_pos": 10138389, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022088.4", "url": "https://www.ensembl.org/id/ENSBTAT00000022088.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022088.2", "url": "https://www.ensembl.org/id/ENSBTAP00000022088.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 42, "start_aa": "Thr", "end_pos": 42, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr42", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:538906", 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"strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005214", "url": "https://www.ensembl.org/id/ENSBTAG00000005214" } ] } } ], "crossref": [ { "id": "E1B708", "url": "https://alphafold.ebi.ac.uk/entry/E1B708", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005214", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005214", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "518599", "url": "https://www.ncbi.nlm.nih.gov/gene/518599", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001360", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001360", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018120", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018120", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033132", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033132", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518599", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518599", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HGSNDFY", "url": "https://omabrowser.org/oma/group/HGSNDFY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B708", "url": "https://www.orthodb.org/?gene=E1B708", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10353", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10353", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10353:SF336", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10353:SF336", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00232", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00232", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179422", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13269", "url": "https://www.rhea-db.org/rhea/13269", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "14297", "url": "https://www.rhea-db.org/rhea/14297", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "43908", "url": "https://www.rhea-db.org/rhea/43908", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "59284", "url": "https://www.rhea-db.org/rhea/59284", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "59288", "url": "https://www.rhea-db.org/rhea/59288", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "59292", "url": "https://www.rhea-db.org/rhea/59292", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "70239", "url": "https://www.rhea-db.org/rhea/70239", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1B708", "url": "https://www.uniprot.org/uniprotkb/E1B708", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B708-1", "url": "https://www.uniprot.org/uniprotkb/E1B708-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKPVRVVTLCWVLLLVSRLGATRKESPEEASFYYGNFPLGFSWGVGSSAFQTEGAWDQHGKGPSIWDTFTHSGKGNVLGDETADVACNSYYKVQEDVALLRELRVSHYRFSLSWPRLLPTGVRADGVNRKGIQFYSDFIDALVKSNITPIVTLHHWDLPQLLQAKYGGWQNVSMANYFSDYANLCFEAFGDRVKHWVTFSDPRTMAEEGYETGHHAPGLKLQGTGLYKAAHHVIKAHAQAWHAYNDTWRSQQQGLVGISLNCDWGEPVDLSNPKDIEAAERYLQFCLGWFANPIYAGDYPQVMKDHIGRKSAEQGLEMSRLPVFSLQEKSYIKGTSDFLGLGHFTTRFITERSYPSGQGPSYQNDRDLVELVDPNWLDLGSKWLYSVPWGFRRLLNFAQTQYGNPLIYVTENGASQRLHCTQLCDEWRIQYLKGYTNEMLKAIKDGANVKGYTSWSLLDKFEWERGYSDRYGFYYIDFNKKNRPRYPKASVEYYKRIIIANGFPNQREVETWYFKALEICSINNRMLAAEPLLSYMQIVTEIVVPTVCTLCILIAAVLLMLLLRSLS", "length": 567, "header": "tr|E1B708-1|E1B708_BOVIN Isoform 1 of Cytosolic beta-glucosidase OS=Bos taurus OX=9913 GN=LCTL PE=3 SV=1 CANONICAL=E1B708-1" }, "isoforms": [ { "isoform_ac": "E1B708-1", "url": "https://www.uniprot.org/uniprotkb/E1B708/entry#E1B708-1", "sequence": { "sequence": "MKPVRVVTLCWVLLLVSRLGATRKESPEEASFYYGNFPLGFSWGVGSSAFQTEGAWDQHGKGPSIWDTFTHSGKGNVLGDETADVACNSYYKVQEDVALLRELRVSHYRFSLSWPRLLPTGVRADGVNRKGIQFYSDFIDALVKSNITPIVTLHHWDLPQLLQAKYGGWQNVSMANYFSDYANLCFEAFGDRVKHWVTFSDPRTMAEEGYETGHHAPGLKLQGTGLYKAAHHVIKAHAQAWHAYNDTWRSQQQGLVGISLNCDWGEPVDLSNPKDIEAAERYLQFCLGWFANPIYAGDYPQVMKDHIGRKSAEQGLEMSRLPVFSLQEKSYIKGTSDFLGLGHFTTRFITERSYPSGQGPSYQNDRDLVELVDPNWLDLGSKWLYSVPWGFRRLLNFAQTQYGNPLIYVTENGASQRLHCTQLCDEWRIQYLKGYTNEMLKAIKDGANVKGYTSWSLLDKFEWERGYSDRYGFYYIDFNKKNRPRYPKASVEYYKRIIIANGFPNQREVETWYFKALEICSINNRMLAAEPLLSYMQIVTEIVVPTVCTLCILIAAVLLMLLLRSLS", "length": 567, "header": "tr|E1B708-1|E1B708_BOVIN Isoform 1 of Cytosolic beta-glucosidase OS=Bos taurus OX=9913 GN=LCTL PE=3 SV=1 CANONICAL=E1B708-1" }, "locus": { "chromosome": "10", "start_pos": 13420411, "end_pos": 13404476, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006868.5", "url": "https://www.ensembl.org/id/ENSBTAT00000006868.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006868.4", "url": "https://www.ensembl.org/id/ENSBTAP00000006868.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:518599", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518599", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JT97-1", "protein_name": "Lactase-like protein", "gene_name": "Lctl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKPVWVVILGWILLVPRVGTAQRGPPEEASFYHGTFPPGFSWGMGSSAYQTKDAWDQDGEGPSSWDNFTHGRKGQVLGGDTADSACDSYYKLQEDIALLKELQVSHYQFSLSWPRLLPTGIRAEQVNKNEIKFYSDFIDALLRSNITPIVTLYHWELPQMLQVTYGGWQNVSMTGYFRDYADLCFEVFGDRVKHWLTFSDPRTMVEKVYETGLHTPGLRLQGTGLYMAAHHIIKAHAQAWHSYNNTWRSKQHGLVGISLDCDWGEPMDIHNPDDLEAAERYLQFCLGWFANPIYAGDYPQVMKDHIGTKSAKQGLEMSRLPTFSLQEKSYLKGTSDFLGLGHFTTRYITQRKYPSHQGPSYQNDRDLIELVDPNWPEIGSPWLYSVPWGFRRLLNFAQTQYGDPLIYVTESGAPQNLHCTQFCDEWRIQYLKGYINEMLKAIKDGVDIKGYTSRSLLDKFEWEKYGFYYIEFNVRNKPRYPKASVQYYKEIITANGFPNSQEVESWRLKALETCSINNQMLATEPLLRRMHVPSEIVVPTVCVLSILIAALLLTLLLRSHS", "length": 561 }, "evidence": [ { "id": "E1B708", "url": "https://omabrowser.org/oma/group/E1B708/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A2R8QQ58-1", "protein_name": "Cytosolic beta-glucosidase", "gene_name": "lctlb", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMLLQRVGPACHVLVLVLCLSAAEDFDWSANNHDSFYYGTFPNGFSWGAGGSAYQTEGAWDKDGKGLSIWDVFTHNKGKTFLNDTGDSSCDGYYKIKDDISLMKEMNLNHYRFSISWPRIMPTGIRSDHVNEKGVRYYDVLIDELLENKITPIVTLYHWDLPQVLQEKYGGWQNISMINYFNDFANLCFERYGDRVKHWITFNNPWSVAVEGYETGEHAPGLKLRGTGAYRAAHHIIKAHAKVWHTYDSQWRSKQKGMVGISLSGDWGEPVDITNQKDIEAAERYVQFYIGWFATPIFHGDYPQVMKDFIGRKSALQGLGTSRLPTFSSQEKSYIKGTSDFLGVGHFTTRYITQKSYPSNRGTTYFSDRDVAELVDPRWPDPGSEWLYSVPWGFRRLLNFMKTHYGNPMIYITENGVSEKMMCTELCDDWRIKYYKDYINEMLKAIRDGVNVKGYTAWSLLDKFEWDEGYSERFGLYYVDFKNQNKPRYPKASVQFYKRIIQSNGFPGQREVETWKRKATETCSTSNQLLAADPLTSHMEMVTEVVVPTVCTLCILISAVFLMFLLRKRN", "length": 570 }, "evidence": [ { "id": "E1B708", "url": "https://omabrowser.org/oma/group/E1B708/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8C2MIL7-1", "protein_name": "Lactase-like protein", "gene_name": "Lctl", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKPVWVIILVWILLVPRVGTARRGSAEEASFHYGTFPPGFSWGVGSSAYQTEGAWDQDGKGPSIWDAFTHGRKGQVLGDDTADAACDSYYKVQEDIALVKELRVSHYRFSLSWPRILPTGVRAEQVNKRGIKFYSDFIDALLKSNITPIVTLHHWDLPQMLQVTYGGWQNVSMTRYFRDYADLCFEVFGDRVKHWLTFSDPRTMVEKGYETGLHAPGLRLQGMGLYMAAHHIIKAHAQAWHSYNNTWRSKQQGMVGISLNCDWGEPVDINNPNDTEAAERYLQFCLGWFANPIYAGDYPQVMKDHIGTKSAEQGLEMSRLPTFSLQEKSYIKGTSDFLGLGHFTTRYITQRTYPSHQGPSYQNDRAVIEFVDPNWPDMGSSWLYSVPWGFRRLLNFVQTQYGHPLIYVTENGAPQKLHYTQLCDEWRIQYLKGYINEMLKAIKDGVNIKGYTSWSLLDKFEWENGYADRYGFYYVEFNVRNKPRYPKASVQYYKEIITANGFPNPREVESWRLKALETCSINNQMLATEPLLRHMRVASEIVVPTVCVLSILIAALLLTLLLRSHG", "length": 566 }, "evidence": [ { "id": "E1B708", "url": "https://omabrowser.org/oma/group/E1B708/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6UWM7-1", "protein_name": "Lactase-like protein", "gene_name": "LCTL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKPVWVATLLWMLLLVPRLGAARKGSPEEASFYYGTFPLGFSWGVGSSAYQTEGAWDQDGKGPSIWDVFTHSGKGKVLGNETADVACDGYYKVQEDIILLRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDALLSSNITPIVTLHHWDLPQLLQVKYGGWQNVSMANYFRDYANLCFEAFGDRVKHWITFSDPRAMAEKGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKAWHSYNTTWRSKQQGLVGISLNCDWGEPVDISNPKDLEAAERYLQFCLGWFANPIYAGDYPQVMKDYIGRKSAEQGLEMSRLPVFSLQEKSYIKGTSDFLGLGHFTTRYITERNYPSRQGPSYQNDRDLIELVDPNWPDLGSKWLYSVPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHCTQLCDEWRIQYLKGYINEMLKAIKDGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYPKASVQYYKKIIIANGFPNPREVESWYLKALETCSINNQMLAAEPLLSHMQMVTEIVVPTVCSLCVLITAVLLMLLLRRQS", "length": 567 }, "evidence": [ { "id": "E1B708", "url": "https://omabrowser.org/oma/group/E1B708/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8K1F9-1", "protein_name": "Lactase-like protein", "gene_name": "Lctl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKPVWVIILGWILLVPRVGTAWRGPPEEASFYYGTFPPGFSWGVGSSAYQTEGAWDEDGKGPSIWDAFTHGRKEQVLGGDTADTACDSYYKVQEDIALLKELQVSHYRFSLSWPRLLPTGVRAEQVNKRGIKFYSDFIDALLKSNITPVVTLHHWDLPQMLQVAYGGWQNVSMTRYFSDYADLCFEVFGDRVKHWLTFSDPRTMVEKGYETGLHAPGLRLQGTGLYVAAHHIIKAHAQAWHSYNNTWRSKQHGLVGISLNCDWGEPVDIDNPDDIEAAERYLQFCLGWFANPIYAGDYPQVMKDHIGTKSAEQGLEMSRLPTFSLQEKSYLKGTSDFLGLGHFTTRYITQRKYPSHQGPSYQNDRDLVELVDPNWPEMGSPWLYSVPWGFRRLLNFAQTQYGDPPIYVTESGAPQKLHCTQFCDEWRIQYLKGYINEMLKAIKDGVDIKGYTSWSLLDKFEWEKGYADKYGFYYVEFNVRNKPRYPKASVQYYKEIITASGFPNPQEVESWRLKALETCSINNQMLATEPLLRHMHVASEIVVPTVCALSILTAALMLTLLLRRRG", "length": 566 }, "evidence": [ { "id": "E1B708", "url": "https://omabrowser.org/oma/group/E1B708/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9FIW4-1", "protein_name": "Beta-glucosidase 42", "gene_name": "BGLU42", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAQKLNLLNLAVPPVTHRSNFPSTFTFGVATSAYQIEGGWNEGKKGPSIWDKFTHIEGKILDGSNGDVAVDHYHRYKEDVDLIGQLGFGAYRFSISWSRIFPDGLGTEVNEEGIAFYNDLINTLLEKGIQPYVTLYHWDLPSHLQEAIGGWTNRKIVDYFGLYADACFANFGDRVKHWITLNEPLQTSVNGHCIGIFAPGRNEKPLIEPYLVSHHQVLAHATAVSIYRSKYKESQGGQIGLSVDCEWAEPNSEKPEDKVAADRRIDFQLGWFLDPLFFGDYPASMRQKLGDNLPRFTPEEKEFMLQNSWDFLGLNHYTSRLISHVSNKEAESNFYQAQELERIVELENGDLIGERAASDWLYAVPWGIRKTLNYMSKKYNHPPIFITENGMDDEDDGSASIHDMLDDKRRVDYFKSYLANVSQAIEDGVDIKGYFAWSLLDNFEWAQGYTKRFGLVYVDYKNGLTRHPKSSAYWFMKFLKGDEENKGKKE", "length": 490 }, "evidence": [ { "id": "E1B708", "url": "https://omabrowser.org/oma/group/E1B708/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "glucosylceramidase activity", "id": "GO:0004348", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004348", "evidence": [ { "database": "UniProtKB", "id": "E1B708", "url": "https://www.uniprot.org/uniprotkb/E1B708" } ], "pmid": "" }, { "name": "beta-glucosidase activity", "id": "GO:0008422", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008422", "evidence": [ { "database": "UniProtKB", "id": "E1B708", "url": "https://www.uniprot.org/uniprotkb/E1B708" } ], "pmid": "" }, { "name": "galactosylceramidase activity", "id": "GO:0004336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004336", "evidence": [ { "database": "UniProtKB", "id": "E1B708", "url": "https://www.uniprot.org/uniprotkb/E1B708" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "E1B708", "url": "https://www.uniprot.org/uniprotkb/E1B708" } ], "pmid": "" }, { "name": "brush border", "id": "GO:0005903", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005903", "evidence": [ { "database": "UniProtKB", "id": "E1B708", "url": "https://www.uniprot.org/uniprotkb/E1B708" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "carbohydrate catabolic process", "id": "GO:0016052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016052", "evidence": [ { "database": "UniProtKB", "id": "E1B708", "url": "https://www.uniprot.org/uniprotkb/E1B708" } ], "pmid": "" }, { "name": "lens morphogenesis in camera-type eye", "id": "GO:0002089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002089", "evidence": [ { "database": "UniProtKB", "id": "E1B708", "url": "https://www.uniprot.org/uniprotkb/E1B708" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13269", "name": "", "equation": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9RY95-1", "F1MND2-1", "Q2KHZ8-1", "F1MNT6-1", "E1B708-1" ], "evidence": [ { "id": "13269", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13269" } ] }, { "id": "14297", "name": "", "equation": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9RY95-1", "Q2KHZ8-1", "F1MNT6-1", "F1MND2-1", "E1B708-1" ], "evidence": [ { "id": "14297", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14297" } ] }, { "id": "43908", "name": "", "equation": "beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O = sphing-4-enine + D-galactose", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SDL9-1", "F1MNT6-1", "E1B708-1" ], "evidence": [ { "id": "43908", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43908" } ] }, { "id": "59284", "name": "", "equation": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MNT6-1", "E1B708-1" ], "evidence": [ { "id": "59284", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/59284" } ] }, { "id": "59288", "name": "", "equation": "beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O = sphing-4-enine + D-glucose", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MNT6-1", "E1B708-1" ], "evidence": [ { "id": "59288", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/59288" } ] }, { "id": "59292", "name": "", "equation": "beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-galactose", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MNT6-1", "E1B708-1" ], "evidence": [ { "id": "59292", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/59292" } ] }, { "id": "70239", "name": "", "equation": "a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9RY95-1", "Q2KHZ8-1", "F1MNT6-1", "E1B708-1" ], "evidence": [ { "id": "70239", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70239" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9RY95", "gene_name": "GBA1", "activity": [ { "ec_number": "3.2.1.45", "activity": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose.", "evidence": [ { "id": "A0AAA9RY95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY95" } ] }, { "ec_number": "3.2.1.45", "activity": "", "evidence": [ { "id": "A0AAA9RY95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY95" } ] } ] }, { "uniprot_ac": "A0AAA9SDL9", "gene_name": "GALC", "activity": [ { "ec_number": "3.2.1.46", "activity": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose.", "evidence": [ { "id": "A0AAA9SDL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDL9" } ] }, { "ec_number": "3.2.1.46", "activity": "", "evidence": [ { "id": "A0AAA9SDL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDL9" } ] } ] }, { "uniprot_ac": "E1B708", "gene_name": "LCTL", "activity": [ { "ec_number": "3.2.1.45", "activity": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose.", "evidence": [ { "id": "E1B708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B708" } ] }, { "ec_number": "3.2.1.21", "activity": "Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.", "evidence": [ { "id": "E1B708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B708" } ] }, { "ec_number": "3.2.1.46", "activity": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose.", "evidence": [ { "id": "E1B708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B708" } ] }, { "ec_number": "3.2.1.45", "activity": "", "evidence": [ { "id": "E1B708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B708" } ] }, { "ec_number": "3.2.1.21", "activity": "", "evidence": [ { "id": "E1B708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B708" } ] }, { "ec_number": "3.2.1.46", "activity": "", "evidence": [ { "id": "E1B708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B708" } ] } ] }, { "uniprot_ac": "F1MND2", "gene_name": "GBA2", "activity": [ { "ec_number": "3.2.1.45", "activity": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose.", "evidence": [ { "id": "F1MND2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MND2" } ] }, { "ec_number": "3.2.1.45", "activity": "", "evidence": [ { "id": "F1MND2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MND2" } ] } ] }, { "uniprot_ac": "F1MNT6", "gene_name": "GBA3", "activity": [ { "ec_number": "3.2.1.45", "activity": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose.", "evidence": [ { "id": "F1MNT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNT6" } ] }, { "ec_number": "3.2.1.21", "activity": "Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.", "evidence": [ { "id": "F1MNT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNT6" } ] }, { "ec_number": "3.2.1.46", "activity": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose.", "evidence": [ { "id": "F1MNT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNT6" } ] }, { "ec_number": "3.2.1.45", "activity": "", "evidence": [ { "id": "F1MNT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNT6" } ] }, { "ec_number": "3.2.1.21", "activity": "", "evidence": [ { "id": "F1MNT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNT6" } ] }, { "ec_number": "3.2.1.46", "activity": "", "evidence": [ { "id": "F1MNT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNT6" } ] } ] }, { "uniprot_ac": "Q2KHZ8", "gene_name": "GBA1", "activity": [ { "ec_number": "3.2.1.45", "activity": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose.", "evidence": [ { "id": "Q2KHZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ8" } ] }, { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q2KHZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ8" } ] }, { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "Q2KHZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ8" } ] }, { "ec_number": "3.2.1.46", "activity": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose.", "evidence": [ { "id": "Q2KHZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ8" } ] }, { "ec_number": "3.2.1.45", "activity": "", "evidence": [ { "id": "Q2KHZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHZ8" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B708-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 567, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B708-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B708" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.2.1.45", "ec_name": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose.", "evidence": [ { "id": "3.2.1.45", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.45" }, { "id": "3.2.1.45", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.2.1.45" } ] }, { "ec_number": "3.2.1.21", "ec_name": "Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.", "evidence": [ { "id": "3.2.1.21", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.2.1.21" } ] }, { "ec_number": "3.2.1.46", "ec_name": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose.", "evidence": [ { "id": "3.2.1.46", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.46" }, { "id": "3.2.1.46", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.2.1.46" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 146, "end_pos": 148 }, { "start_pos": 171, "end_pos": 173 }, { "start_pos": 245, "end_pos": 247 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B755-1", "uniprot_ac": "E1B755", "uniprot_id": "E1B755_BOVIN", "mass": { "chemical_mass": 256757.0, "monoisotopic_mass": 256757.0 }, "refseq": { "ac": "NP_001179484", "name": "phosphatidylinositol phosphatase PTPRQ precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179484" }, "gene_names": [ { "name": "PTPRQ", "type": "recommended", "evidence": [ { "id": "E1B755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B755" } ] }, { "name": "PTPRQ", "type": "synonym", "evidence": [ { "id": "NP_001179484", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179484" } ] } ], "protein_names": [ { "name": "Phosphatidylinositol phosphatase PTPRQ", "type": "recommended", "evidence": [ { "id": "E1B755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B755/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.67", "type": "synonym", "evidence": [ { "id": "E1B755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B755/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.86", "type": "synonym", "evidence": [ { "id": "E1B755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B755/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.95", "type": "synonym", "evidence": [ { "id": "E1B755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B755/entry#names_and_taxonomy" } ] }, { "name": "Receptor-type tyrosine-protein phosphatase Q", "type": "synonym", "evidence": [ { "id": "E1B755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B755/entry#names_and_taxonomy" } ] }, { "name": "phosphatidylinositol phosphatase PTPRQ precursor", "type": "synonym", "evidence": [ { "id": "NP_001179484", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179484" } ] }, { "name": "tyrosine phosphatase receptor type Q", "type": "synonym", "evidence": [ { "id": "NP_001179484", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179484" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B755", "url": "https://www.uniprot.org/uniprotkb/E1B755" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTPRQ", "url": "https://www.uniprot.org/uniprotkb/E1B755", "locus": { "chromosome": "5", "start_pos": 10250997, "end_pos": 10019454, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026977", "url": "https://www.ensembl.org/id/ENSBTAG00000026977" } ] } } ], "crossref": [ { "id": "ENSBTAG00000026977", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026977", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14616", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14616", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "522188", "url": "https://www.ncbi.nlm.nih.gov/gene/522188", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000242", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000242", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050713", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050713", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522188", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522188", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1B755", "url": "https://www.orthodb.org/?gene=E1B755", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46957", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46957", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46957:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46957:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00102", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00102", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179484", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "25017", "url": "https://www.rhea-db.org/rhea/25017", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "25528", "url": "https://www.rhea-db.org/rhea/25528", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "32955", "url": "https://www.rhea-db.org/rhea/32955", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "39019", "url": "https://www.rhea-db.org/rhea/39019", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1B755", "url": "https://www.uniprot.org/uniprotkb/E1B755", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B755-1", "url": "https://www.uniprot.org/uniprotkb/E1B755-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDFLIIFLLLFIGTSETQADVSNAVPGTRYEVTISSISATTYSSPVSRTVATNVTKPGPPVFLAGERVGSAGILLSWNTPPNPNGRIISYIVKYKEVCPWMQATYTQVRTKPDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAFNYSAVNLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENNESFLWSTTSPSPTLGRVTPPPRTTYLSSMLSQSKISSVWKEPISFVVTHLRPYTTYLFEVSAVTTEAGYIDSTIVRTPESVPEGPPQNCLTGNITGRSFAISWDPPTVVTGKFSYRVELYGPSGRILDNSTKDLKFAFTNLTPFTVYDAYVAAETSAGIGPKSNISVFTPPEAPGAVFDLQVAEVEATEIRITWKKPRQPNGIINQYRVRVLVSETRVILEDTLLIGKDEVQYINPMAPETVSIVESMAGLFEGSAEMSSDLYSLASVIYNSHPRNYFPVRGRAEDQPSTFGTSRNQYITDIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTLEQVPSSIQVINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQMTTIDNNFLITGLKKYTRYKMRVAASTTVGESSLSEANDIFVRTPEDEPESSPQDVEVTDVTASEISLKWSPPEKPNGIIVAYEVLYRNVNSLFMKNTSTTNIILRDLKPYSLYNVSVRSYTRFGHGEQLSSVLSVRTSETVPDSAPENITYRNISSGEIELSFFPPSSPNGIIQKYTIYLMKSNGNEERTINTTSLVQNIKGLKKYTQYTIEVSASTLKGEGIRSAPINVLTEEDAPDSPPQDFSVKQLSGVMVKLSWQPPLEPNGIILYYTVYVWDRSSLKTVNVTETSLEFSDLDHNVEYNAYVTASTRFGDGEKRSNIINFRTPEGAPSDPPKDVQYSNLSSSSILLFWTPPSKPNGIIQYYSVYYRNTSGTFIQNFTLHEVNDFDNMTVSAIIDKLAIFSYYTFWVTASTSVGNGNKSSGIVHVYTDQDIPEGVVGNLTYESISSTAVNVSWGPPSQPNGLVFYYVSLSSQQTPRHVRPPLVTYERSMYFDNLDKYTDYILKVTPSTEKGFSDAYTAQLHIRTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPSENYSFVTSDNYVILEELSPFTLYSFFAAARTIKGLGPSSVLFFYTDESVPLAPPQNLTLVNYTSDLVWLKWSPSPVPGGIVKIYSLKIHEHETDTIFYKNISGFQTEAKLVGLEPVSTYSISITAFTKVGNGNQFSNVVKFTTQESVPDVVQNIQCMATSWQSASVKWDPPKKANGIITHYTITVERNATNISPQDHMYTFMKLLANTSYVFEIRASTSAGEGNEMTCNVSTLPETVPSVPMNIAFSNVQSTSATLTWMRPDSIFGYFQNYKITTQLRAKKCREWDSEDCVEHQKIQYLYEADLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTQTLPGPPDGPPENVHVVATSPFSINISWSEPTVITGPTFYLIDVKSVDSDEFNISLIKSNEENKTIEVKDLEIFTRYSVVITAFTGNISAAYVDGKSSAEIIVTTLESVPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQIHNLSIIQKTDTSVIAMLEGLKGGHTYNISVYAINSAGAGPKVQMRITMDIKAPARPKTKPTPIYDATGKLLVTSTTITIRMPICYYNDDHGPIKNVQVLVAEAGAQHDGNVTKWYDAYFNKPRPYFTNEGFPNPPCTEGKAKFSGSEEIYIIGADRACMIPGNEDKICNGPLKPKKQYLFKFRATNIMGQFTDSDYSDPVKTLSEGLSERTVEIILSVTLCILSIILLGTAVFAFARIRQKQKEGGTYSPRDAEIIDTKFKLDQLITVADLELKDERLTRLLSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASIPGSDYINASYVSGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTIRQCNFTAWPEHGVPENSAPLVHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCVLDLLSSKGNNQLICFVNYSALQKMDSLDAMEGDVELEWEETTM", "length": 2300, "header": "tr|E1B755-1|E1B755_BOVIN Isoform 1 of Phosphatidylinositol phosphatase PTPRQ OS=Bos taurus OX=9913 GN=PTPRQ PE=3 SV=4 CANONICAL=E1B755-1" }, "isoforms": [ { "isoform_ac": "E1B755-1", "url": "https://www.uniprot.org/uniprotkb/E1B755/entry#E1B755-1", "sequence": { "sequence": 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"length": 2300, "header": "tr|E1B755-1|E1B755_BOVIN Isoform 1 of Phosphatidylinositol phosphatase PTPRQ OS=Bos taurus OX=9913 GN=PTPRQ PE=3 SV=4 CANONICAL=E1B755-1" }, "locus": { "chromosome": "5", "start_pos": 10250699, "end_pos": 10019454, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048152.5", "url": "https://www.ensembl.org/id/ENSBTAT00000048152.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045240.5", "url": "https://www.ensembl.org/id/ENSBTAP00000045240.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:522188", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522188", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity", "id": "GO:0016314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016314", "evidence": [ { "database": "UniProtKB", "id": "E1B755", "url": "https://www.uniprot.org/uniprotkb/E1B755" } ], "pmid": "" }, { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "E1B755", "url": "https://www.uniprot.org/uniprotkb/E1B755" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity", "id": "GO:0052629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052629", "evidence": [ { "database": "UniProtKB", "id": "E1B755", "url": "https://www.uniprot.org/uniprotkb/E1B755" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "id": "GO:0034485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034485", "evidence": [ { "database": "UniProtKB", "id": "E1B755", "url": "https://www.uniprot.org/uniprotkb/E1B755" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "E1B755", "url": "https://www.uniprot.org/uniprotkb/E1B755" } ], "pmid": "" }, { "name": "detection of mechanical stimulus involved in sensory perception of sound", "id": "GO:0050910", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050910", "evidence": [ { "database": "UniProtKB", "id": "E1B755", "url": "https://www.uniprot.org/uniprotkb/E1B755" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "E1B755", "url": "https://www.uniprot.org/uniprotkb/E1B755" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "E1B755", "url": "https://www.uniprot.org/uniprotkb/E1B755" } ], "pmid": "" }, { "name": "basal plasma membrane", "id": "GO:0009925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009925", "evidence": [ { "database": "UniProtKB", "id": "E1B755", "url": "https://www.uniprot.org/uniprotkb/E1B755" } ], "pmid": "" }, { "name": "stereocilium base", "id": "GO:0120044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120044", "evidence": [ { "database": "UniProtKB", "id": "E1B755", "url": "https://www.uniprot.org/uniprotkb/E1B755" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1009, "end_pos": 1011, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1039, "end_pos": 1041, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1060, "end_pos": 1062, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1072, "end_pos": 1074, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1162, "end_pos": 1164, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1195, "end_pos": 1197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1249, "end_pos": 1251, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1254, "end_pos": 1256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1293, "end_pos": 1295, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1381, "end_pos": 1383, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1384, "end_pos": 1386, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1400, "end_pos": 1402, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1422, "end_pos": 1424, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1525, "end_pos": 1527, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1557, "end_pos": 1559, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1585, "end_pos": 1587, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1595, "end_pos": 1597, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1619, "end_pos": 1621, "annotation": "n_glycosylation_sequon" }, { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1648, "end_pos": 1650, "annotation": "n_glycosylation_sequon" }, { "start_pos": 168, "end_pos": 170, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1695, "end_pos": 1697, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1720, "end_pos": 1722, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1803, "end_pos": 1805, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2060, "end_pos": 2062, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2163, "end_pos": 2165, "annotation": "n_glycosylation_sequon" }, { "start_pos": 224, "end_pos": 226, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2274, "end_pos": 2276, "annotation": "n_glycosylation_sequon" }, { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 353, "end_pos": 355, "annotation": "n_glycosylation_sequon" }, { "start_pos": 364, "end_pos": 366, "annotation": "n_glycosylation_sequon" }, { "start_pos": 388, "end_pos": 390, "annotation": "n_glycosylation_sequon" }, { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" }, { "start_pos": 581, "end_pos": 583, "annotation": "n_glycosylation_sequon" }, { "start_pos": 715, "end_pos": 717, "annotation": "n_glycosylation_sequon" }, { "start_pos": 733, "end_pos": 735, "annotation": "n_glycosylation_sequon" }, { "start_pos": 767, "end_pos": 769, "annotation": "n_glycosylation_sequon" }, { "start_pos": 772, "end_pos": 774, "annotation": "n_glycosylation_sequon" }, { "start_pos": 811, "end_pos": 813, "annotation": "n_glycosylation_sequon" }, { "start_pos": 904, "end_pos": 906, "annotation": "n_glycosylation_sequon" }, { "start_pos": 961, "end_pos": 963, "annotation": "n_glycosylation_sequon" }, { "start_pos": 990, "end_pos": 992, "annotation": "n_glycosylation_sequon" }, { "start_pos": 998, "end_pos": 1000, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "25017", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9U0H6-1", "E1B755-1" ], "evidence": [ { "id": "25017", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/25017" } ] }, { "id": "25528", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BBJ7-1", "A0AAA9U0Y4-1", "E1B755-1", "E1BAU6-1", "O18964-1" ], "evidence": [ { "id": "25528", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/25528" } ] }, { "id": "32955", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1B755-1", "E1BAU6-1" ], "evidence": [ { "id": "32955", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/32955" } ] }, { "id": "39019", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A6QLT4-1", "A6QLT2-1", "E1B755-1", "O18964-1" ], "evidence": [ { "id": "39019", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39019" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9U0H6", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", 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"Protein Classification" ] }, { "id": "IPR035965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050818", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050818", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514409", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514409", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YIGQQEI", "url": "https://omabrowser.org/oma/group/YIGQQEI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B760", "url": "https://www.orthodb.org/?gene=E1B760", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10217", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10217", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10217:SF481", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10217:SF481", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00027", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00027", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13426", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13426", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1296072", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179300", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179300", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29463", "url": "https://www.rhea-db.org/rhea/29463", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1B760", "url": "https://www.uniprot.org/uniprotkb/E1B760", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B760-1", "url": "https://www.uniprot.org/uniprotkb/E1B760-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVALFLVSHKDISETKNRGGPDSWKESGGGRRRYGRAGSKGFNANRRRSRAVLYHLSGHLQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAALPFDLLHAFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQREIESSASELPEIGWLQELARRLETPYYLVGRSPAAGNSSGQSDNCSSSFGEANRTGPELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVKANADVKGLTYCVLQCLQLAGLHESLALYPEFAPRFSRGLRGELSYNLGAGGGPAEADTSSLSGDNTLMSTLEEKETDGEQGPAASPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTVPRSRLGGRGRPGRAGALQAEAGPSTHPRSLEGLRLPPVPWNVPPDLSPRVVDGIEDGCGSDQPQFSFRVRQSGPECSSSPSPGPENGLLTVPLGPSEVRNTDTLDKLRQAVMELSEQVLQMREGLQSLRQAVQLVLAPRGEGPCPAGASGLLQPLCVDTGASSCCLQPSAGSVLSGTWPHPRPGPPPLMAPWPWGPPASQSSPWPRATAFWTSTSDSEPPGSGELCPEPSTPGLPPPEEGARTGPPEPMTQAEAASTGEPPPASGGHALPWEPHSLEMVLIGCHGSGTVQWTQEEGTGV", "length": 1074, "header": "tr|E1B760-1|E1B760_BOVIN Isoform 1 of Voltage-gated inwardly rectifying potassium channel KCNH3 OS=Bos taurus OX=9913 GN=KCNH3 PE=3 SV=1 CANONICAL=E1B760-1" }, "isoforms": [ { "isoform_ac": "E1B760-1", "url": "https://www.uniprot.org/uniprotkb/E1B760/entry#E1B760-1", "sequence": { "sequence": "MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVALFLVSHKDISETKNRGGPDSWKESGGGRRRYGRAGSKGFNANRRRSRAVLYHLSGHLQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAALPFDLLHAFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQREIESSASELPEIGWLQELARRLETPYYLVGRSPAAGNSSGQSDNCSSSFGEANRTGPELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVKANADVKGLTYCVLQCLQLAGLHESLALYPEFAPRFSRGLRGELSYNLGAGGGPAEADTSSLSGDNTLMSTLEEKETDGEQGPAASPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTVPRSRLGGRGRPGRAGALQAEAGPSTHPRSLEGLRLPPVPWNVPPDLSPRVVDGIEDGCGSDQPQFSFRVRQSGPECSSSPSPGPENGLLTVPLGPSEVRNTDTLDKLRQAVMELSEQVLQMREGLQSLRQAVQLVLAPRGEGPCPAGASGLLQPLCVDTGASSCCLQPSAGSVLSGTWPHPRPGPPPLMAPWPWGPPASQSSPWPRATAFWTSTSDSEPPGSGELCPEPSTPGLPPPEEGARTGPPEPMTQAEAASTGEPPPASGGHALPWEPHSLEMVLIGCHGSGTVQWTQEEGTGV", "length": 1074, "header": "tr|E1B760-1|E1B760_BOVIN Isoform 1 of Voltage-gated inwardly rectifying potassium channel KCNH3 OS=Bos taurus OX=9913 GN=KCNH3 PE=3 SV=1 CANONICAL=E1B760-1" }, "locus": { "chromosome": "5", "start_pos": 30292817, "end_pos": 30274568, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025668.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025668.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025668.4", "url": "https://www.ensembl.org/id/ENSBTAP00000025668.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1006, "start_aa": "Thr", "end_pos": 1006, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1006", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 241, "start_aa": "Thr", "end_pos": 241, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr241", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:514409", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514409", "resource": "KEGG Pathway" }, { "id": "R-BTA-1296072", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "resource": "Reactome", "description": "Voltage gated Potassium channels" } ], "orthologs": [ { "uniprot_canonical_ac": "I3LBQ7-1", "protein_name": "Voltage-gated inwardly rectifying potassium channel KCNH3", "gene_name": "KCNH3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVALFLVSHKDISDTKNRGGPDSWKERGGGRRRYGRAGSKGFNANRRRSRAVLYHLSGHLQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAALPFDLLHAFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQREIESSASELPEIGWLQELARRLETPYYLVGRSPAVGNSSGQSDNCSSSGSEANRTGPELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASRGCLRTLSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVKANADVKGLTYCVLQCLQLAGLHESLALYPEFAPRFSRSLRGELSYNLGAGGGPAEADTSSLSGDNTLMSTLEEKETDGEQGPATSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTRPRLGGRGRPGRAAASQAEAGPPAHPRSLEGLRLPSVPWNVPPDLSPRVVDGIEDGCGSDQPKFSFRMRQSGPECSSSPSPGPENSLLTVPLGPSEVRSTDTLDKLRQAVMELSEQVLQMREGLQSLRQAVQLVLAPHGEGPCPRPSGEGPCPAGASGLLQPLCVDTGTSSYCLQPPAGSVLSGTWPHPRPGPSPLVAPWPWGPPASQSSPWPRATAFWTSTSDSEPPGSGERCPEPSTPGSPPPEDGARTGPPEPANQAEAASTGEPPPGAGGLALPWEPHSLEMVLIGCHGSGTVQWTQEEGTGV", "length": 1081 }, "evidence": [ { "id": "E1B760", "url": "https://omabrowser.org/oma/group/E1B760/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O89047-1", "protein_name": "Voltage-gated inwardly rectifying potassium channel KCNH3", "gene_name": "Kcnh3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVALFLVSHKDISETKNRGGPDNWKERGGGRRRYGRAGSKGFNANRRRSRAVLYHLSGHLQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAALPFDLLHAFKVNVYVGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQQEIENSESELPEIGWLQELARRLETPYYLVSRSPDGGNSSGQSENCSSSGGGSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPQREQVVKANADVKGLTYCVLQCLQLAGLHESLALYPEFAPRFSRGLRGELSYNLGAGGVSAEVDTSSLSGDNTLMSTLEEKETDGEQGHTISPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPSRAGVLKPEAGPSAHPRTLDGLQLPPMPWNVPPDLSPRVVDGIEDGCGSDQHKFSFRVGQSGPECSSSPSPGTESGLLTVPLVPSEARNTDTLDKLRQAVTELSEQVLQMREGLQSLRQAVQLILVPQGEGQCPRVSGEGPCPATASGLLQPLRVDTGASSYCLQPPAGSVLSGTWPHPRPGHPPPLMAPWPWGPPASQSSPWPRATALWTSTSDSEPPGSGDLCSEPSTPASPPPPEEGARTGTPAPVSQAEATSTGEPPPGSGGRALPWDPHSLEMVLIGCHGPGSVQWTQEEGTGV", "length": 1087 }, "evidence": [ { "id": "E1B760", "url": "https://omabrowser.org/oma/group/E1B760/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9ULD8-1", "protein_name": "Voltage-gated inwardly rectifying potassium channel KCNH3", "gene_name": "KCNH3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVALFLVSHKDISETKNRGGPDRWKETGGGRRRYGRARSKGFNANRRRSRAVLYHLSGHLQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAALPFDLLHAFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVKANADVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNLGAGGGSAEVDTSSLSGDNTLMSTLEEKETDGEQGPTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPGRAGALKAEAGPSAPPRALEGLRLPPMPWNVPPDLSPRVVDGIEDGCGSDQPKFSFRVGQSGPECSSSPSPGPESGLLTVPHGPSEARNTDTLDKLRQAVTELSEQVLQMREGLQSLRQAVQLVLAPHREGPCPRASGEGPCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGTWPHPRPGPPPLMAPWPWGPPASQSSPWPRATAFWTSTSDSEPPASGDLCSEPSTPASPPPSEEGARTGPAEPVSQAEATSTGEPPPGSGGLALPWDPHSLEMVLIGCHGSGTVQWTQEEGTGV", "length": 1083 }, "evidence": [ { "id": "E1B760", "url": "https://omabrowser.org/oma/group/E1B760/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9WVJ0-1", "protein_name": "Voltage-gated inwardly rectifying potassium channel KCNH3", "gene_name": "Kcnh3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVALFLVSHKDISETKNRGGPDNWKERGGGRRRYGRAGSKGFNANRRRSRAVLYHLSGHLQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAALPFDLLHAFKVNVYVGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQQEIESSESELPEIGWLQELARRLETPYYLVSRSPDGGNSSGQSENCSSSSSSSGSGGGRGSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPQREQVVKANADVKGLTYCVLQCLQLAGLHESLALYPEFAPRFSRGLRGELSYNLGAGGVSAEVDTSSLSGDNTLMSTLEEKETDGEQGHTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPSRAGVLKPEAGPSAHPRSLDGLQLPPMPWNVPPDLSPRVVDGIEDGCSSDQPKFSFRVGQSGPECSSSPSPGTESGLLTVPLGPSEARNTDTLDKLRQAVMELSEQVLQMREGLQSLRQAVQLILVPQGEGQCPRGSGEEPCPATASGLLQPLRVDTGASSYCLQPPAGSVLSGTWPHPRPGQPPPLMAPWPWGPPASQSSPWPRATALWTSTSDSEPPGSGDLCSEPSTPASPPPSEEGARTGTPAPVSQAEATSTGEPPPGPGGRALPWDPHSLEMVLIGCHGPGTVQWTQEEGTGV", "length": 1095 }, "evidence": [ { "id": "E1B760", "url": "https://omabrowser.org/oma/group/E1B760/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B760", "url": "https://www.uniprot.org/uniprotkb/E1B760" } ], "pmid": "" }, { "name": "monoatomic ion channel complex", "id": "GO:0034702", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034702", "evidence": [ { "database": "UniProtKB", "id": "E1B760", "url": "https://www.uniprot.org/uniprotkb/E1B760" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of membrane potential", "id": "GO:0042391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042391", "evidence": [ { "database": "UniProtKB", "id": "E1B760", "url": "https://www.uniprot.org/uniprotkb/E1B760" } ], "pmid": "" }, { "name": "potassium ion transmembrane transport", "id": "GO:0071805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "evidence": [ { "database": "UniProtKB", "id": "E1B760", "url": "https://www.uniprot.org/uniprotkb/E1B760" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "voltage-gated potassium channel activity", "id": "GO:0005249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005249", "evidence": [ { "database": "UniProtKB", "id": "E1B760", "url": "https://www.uniprot.org/uniprotkb/E1B760" } ], "pmid": "" }, { "name": "inward rectifier potassium channel activity", "id": "GO:0005242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005242", "evidence": [ { "database": "UniProtKB", "id": "E1B760", "url": "https://www.uniprot.org/uniprotkb/E1B760" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 421, "end_pos": 423, "annotation": "n_glycosylation_sequon" }, { "start_pos": 428, "end_pos": 430, "annotation": "n_glycosylation_sequon" }, { "start_pos": 437, "end_pos": 439, "annotation": "n_glycosylation_sequon" }, { "start_pos": 471, "end_pos": 473, "annotation": "n_glycosylation_sequon" }, { "start_pos": 500, "end_pos": 502, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29463", "name": "", "equation": "K(+)(in) = K(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35526-1" ], "evidence": [ { "id": "29463", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29463" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P35526", "gene_name": "CLIC5", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "P35526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35526" } ] } ] } ], "biomarkers": [], 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"MENTNDTTGINFILLGLLNYTQIHIFFFSVVLMTFLTSLMSNIFMIMLIRMDSRLCTPMYFLLSQLSLMDVMLVLTVVPKMVGNYLMHIRSISSAGCGAQIFLFVTLEGGECFLLAAMAYDRYVAICHPLRYPILMNQKLCLHMTAGSWLLGGVDGLMQAGVTLSFPYCHSREINHFFCEAPSLVRLACTDTMIFEFFMYICCVLMLLIPVSFILASYGLILITVLRMHSAAARKKAFATCSSHLAVVGFFYGTIIFIYMRPKSYRSVAHDKVVSAFYTIFTPVLNPLIYSVRNKEVKGALRMWLEKYFQ", "length": 310, "header": "tr|E1B767-1|E1B767_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2T54 PE=3 SV=5 CANONICAL=E1B767-1" }, "isoforms": [ { "isoform_ac": "E1B767-1", "url": "https://www.uniprot.org/uniprotkb/E1B767/entry#E1B767-1", "sequence": { "sequence": "MENTNDTTGINFILLGLLNYTQIHIFFFSVVLMTFLTSLMSNIFMIMLIRMDSRLCTPMYFLLSQLSLMDVMLVLTVVPKMVGNYLMHIRSISSAGCGAQIFLFVTLEGGECFLLAAMAYDRYVAICHPLRYPILMNQKLCLHMTAGSWLLGGVDGLMQAGVTLSFPYCHSREINHFFCEAPSLVRLACTDTMIFEFFMYICCVLMLLIPVSFILASYGLILITVLRMHSAAARKKAFATCSSHLAVVGFFYGTIIFIYMRPKSYRSVAHDKVVSAFYTIFTPVLNPLIYSVRNKEVKGALRMWLEKYFQ", "length": 310, "header": "tr|E1B767-1|E1B767_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR2T54 PE=3 SV=5 CANONICAL=E1B767-1" }, "locus": { "chromosome": "7", "start_pos": 41323316, "end_pos": 41322387, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056207.4", "url": "https://www.ensembl.org/id/ENSBTAT00000056207.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050755.4", "url": "https://www.ensembl.org/id/ENSBTAP00000050755.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518816", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518816", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "E1B767", "url": "https://www.uniprot.org/uniprotkb/E1B767" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "E1B767", "url": "https://www.uniprot.org/uniprotkb/E1B767" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B767", "url": "https://www.uniprot.org/uniprotkb/E1B767" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "E1B767", "url": "https://www.uniprot.org/uniprotkb/E1B767" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B767-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 310, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B767-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B767" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B767" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Ser", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 19, "end_pos": 21 }, { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B796-1", "uniprot_ac": "E1B796", "uniprot_id": "E1B796_BOVIN", "mass": { "chemical_mass": 68658.0, "monoisotopic_mass": 68658.0 }, "refseq": { "ac": "XP_010799030", "name": "synaptotagmin-like protein 3 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799030" }, "gene_names": [ { "name": "SYTL3", "type": "recommended", "evidence": [ { "id": "E1B796", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B796" } ] }, { "name": "SYTL3", "type": "synonym", "evidence": [ { "id": "XP_010799030", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799030" } ] } ], "protein_names": [ { "name": "Synaptotagmin-like protein 3", "type": "recommended", "evidence": [ { "id": "E1B796", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B796/entry#names_and_taxonomy" } ] }, { "name": "Exophilin-6", "type": "synonym", "evidence": [ { "id": "E1B796", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B796/entry#names_and_taxonomy" } ] }, { "name": "synaptotagmin-like protein 3 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_010799030", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799030" } ] } ], "function": [ { "annotation": "May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions.", "evidence": [ { "database": "UniProtKB", "id": "E1B796", "url": "https://www.uniprot.org/uniprotkb/E1B796#function" }, { "database": "UniProtKB", "id": "ARBA00059959", "url": "https://www.uniprot.org/uniprotkb/ARBA00059959#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B796", "url": "https://www.uniprot.org/uniprotkb/E1B796" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SYTL3", "url": "https://www.uniprot.org/uniprotkb/E1B796", "locus": { "chromosome": "9", "start_pos": 95156472, "end_pos": 95072584, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010334", "url": "https://www.ensembl.org/id/ENSBTAG00000010334" } ] } } ], "crossref": [ { "id": "E1B796", "url": "https://alphafold.ebi.ac.uk/entry/E1B796", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010334", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010334", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04020", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04020", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08392", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08392", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506884", "url": "https://www.ncbi.nlm.nih.gov/gene/506884", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010911", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010911", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043567", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043567", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506884", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506884", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RKKKCNP", "url": "https://omabrowser.org/oma/group/RKKKCNP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B796", "url": "https://www.orthodb.org/?gene=E1B796", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45716", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45716", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45716:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45716:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02318", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02318", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010799030", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799030", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B796", "url": "https://www.uniprot.org/uniprotkb/E1B796", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B796-1", "url": "https://www.uniprot.org/uniprotkb/E1B796-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQQVSLGSLQESEREAILQVLYRDREVQNTEAERIRNLKTRLQHLRWKGAKSVSQEYKEKSCARCQQTLGLLLNRGAVCQGCSHRVCSECRVFLRRTRAWKCTVCFEDRNVKIKTGDWFFEERAKKFPTEGKHETAGAKLLQSYQKLSNKISVVPPTPPPLSESQCGGGPARLQELGQFKGFNKSVENLFLSVTTHMKKLSKSQNDMTSDKQHPEMVPRQREGRPERRSQSDTAINVTTRAGTPDILKPLGPESPRRPTSPVLKQEDISSSPVLNTSFSGGLRQGSLISINSTCTEMGNFDKADVTGEIEFAIRYCLRTHSLEICIRACKNLAFGEERKKKCNPYVKTYLLPDRSSQGKRKTGVQKNTVEPTFQETLKYQVELAQLASQQLQVSVWHLGVLTRRVFLGEVIVPLATWDFEDRESQSFRWYPLRAKAEKSEDSLPTNNGELAVRAKLVLPAGPRELQEAPEGTGDEPSQNGQLCLVVLGAKNLPVRSDGTLNSFVKGCLTLPDQQRLRLKSPVLKKQACPQWKHSFIFKGVTPSQLRQSSLELTIWDQATFGVNDRFLGGARLGLKEDLPGGAHTSSQAKLQWQKVLSSPNLWTDMTLILH", "length": 611, "header": "tr|E1B796-1|E1B796_BOVIN Isoform 1 of Synaptotagmin-like protein 3 OS=Bos taurus OX=9913 GN=SYTL3 PE=4 SV=2 CANONICAL=E1B796-1" }, "isoforms": [ { "isoform_ac": "E1B796-1", "url": "https://www.uniprot.org/uniprotkb/E1B796/entry#E1B796-1", "sequence": { "sequence": "MAQQVSLGSLQESEREAILQVLYRDREVQNTEAERIRNLKTRLQHLRWKGAKSVSQEYKEKSCARCQQTLGLLLNRGAVCQGCSHRVCSECRVFLRRTRAWKCTVCFEDRNVKIKTGDWFFEERAKKFPTEGKHETAGAKLLQSYQKLSNKISVVPPTPPPLSESQCGGGPARLQELGQFKGFNKSVENLFLSVTTHMKKLSKSQNDMTSDKQHPEMVPRQREGRPERRSQSDTAINVTTRAGTPDILKPLGPESPRRPTSPVLKQEDISSSPVLNTSFSGGLRQGSLISINSTCTEMGNFDKADVTGEIEFAIRYCLRTHSLEICIRACKNLAFGEERKKKCNPYVKTYLLPDRSSQGKRKTGVQKNTVEPTFQETLKYQVELAQLASQQLQVSVWHLGVLTRRVFLGEVIVPLATWDFEDRESQSFRWYPLRAKAEKSEDSLPTNNGELAVRAKLVLPAGPRELQEAPEGTGDEPSQNGQLCLVVLGAKNLPVRSDGTLNSFVKGCLTLPDQQRLRLKSPVLKKQACPQWKHSFIFKGVTPSQLRQSSLELTIWDQATFGVNDRFLGGARLGLKEDLPGGAHTSSQAKLQWQKVLSSPNLWTDMTLILH", "length": 611, "header": "tr|E1B796-1|E1B796_BOVIN Isoform 1 of Synaptotagmin-like protein 3 OS=Bos taurus OX=9913 GN=SYTL3 PE=4 SV=2 CANONICAL=E1B796-1" }, "locus": { "chromosome": "9", "start_pos": 95155468, "end_pos": 95072783, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013647.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013647.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013647.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013647.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 158, "start_aa": "Thr", "end_pos": 158, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr158", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:506884", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506884", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XS62-1", "protein_name": "Synaptotagmin-like protein 3", "gene_name": "SYTL3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MACEFNLNFLKELEREAVLEVLYRDQRVRKTEEERIRKLKMQLHQLRWKGARNVSYEYQERSCARCQKSLGLLMNRGAVCNGCSHRVCSECRVCLNPSLWKCTVCYAHGDVKVKAGEWFFEERAKKYPDEGRHETAGAKLLKSYQKLSKISVVPPTPPPYTESTAGSNMKELGQSKSFNKSVENLFLSLTTHIKKISKSQNDMADRSLLTTDYGHNVERRRQRRSQSDTAINITSRKKSAPSLQDLFYGAQNDSEILTKRNCKQEEDITTSPTSDAVFCDGRKHGSLYSLNSTCTEYGNFGKANVTGEIEFAIRYIFKACILEICIRGCKNLAYGEEKKKKCNPYVKVYLLPDKSSRSKRKTAVKKNTVDPEFDETLKYKIESSQLGSRQLQISVWHAGALKYRVFLGEVVIPLAAWSFEDSSMESFNWYQLQSKHEKPEDNLIQYSGELLVSARLSVPAQYKNFQFERWMMEGKKDQEFSTCQLQVMIFGARNLPVLRSAGTLNSFVKGCLIISDQAELKQKSPVVKKEDCPQWKHLFVFDVTPAQLQQSCLHLTVWDQSTFGYRDHFLGGAKLGAKPSLGFTDPISPSVLQWEEVLRRPNTWMDFTLILHSNMENFKS", "length": 620 }, "evidence": [ { "id": "E1B796", "url": 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377727" }, "gene_names": [ { "name": "OR2AJ9", "type": "recommended", "evidence": [ { "id": "E1B799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B799" } ] }, { "name": "OR2AJ9", "type": "synonym", "evidence": [ { "id": "NP_001377727", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377727" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "E1B799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B799/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 2 subfamily AJ member 9", "type": "synonym", "evidence": [ { "id": "NP_001377727", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377727" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377727" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1B799", "url": "https://www.uniprot.org/uniprotkb/E1B799#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B799", "url": "https://www.uniprot.org/uniprotkb/E1B799" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR2AJ9", "url": "https://www.uniprot.org/uniprotkb/E1B799", "locus": { "chromosome": "7", "start_pos": 41682612, "end_pos": 41681668, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040033", "url": "https://www.ensembl.org/id/ENSBTAG00000040033" } ] } } ], "crossref": [ { "id": "E1B799", "url": "https://alphafold.ebi.ac.uk/entry/E1B799", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15421", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15421", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "112447515", "url": "https://www.ncbi.nlm.nih.gov/gene/112447515", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:112447515", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112447515", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IFIMSVT", "url": "https://omabrowser.org/oma/group/IFIMSVT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B799", "url": "https://www.orthodb.org/?gene=E1B799", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377727", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B799", "url": "https://www.uniprot.org/uniprotkb/E1B799", "database": "UniProtKB", "categories": [ 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"isoforms": [ { "isoform_ac": "E1B7D3-1", "url": "https://www.uniprot.org/uniprotkb/E1B7D3/entry#E1B7D3-1", "sequence": { "sequence": "MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEISRCKSAEEKKPGELKRLVESRRQQILKEFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE", "length": 488, "header": "tr|E1B7D3-1|E1B7D3_BOVIN Isoform 1 of E3 ubiquitin-protein ligase TRIM39 OS=Bos taurus OX=9913 GN=TRIM39 PE=3 SV=4 CANONICAL=E1B7D3-1" }, "locus": { "chromosome": "23", "start_pos": 28465402, "end_pos": 28456603, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010056.7", "url": 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"GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1B7D3", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1B7D3", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B7D3", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B7D3", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1B7D3", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "E1B7D3", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "E1B7D3", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "E1B7D3", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ], "pmid": "" }, { "name": "positive regulation of apoptotic signaling pathway", "id": "GO:2001235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001235", "evidence": [ { "database": "UniProtKB", "id": "E1B7D3", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "E1B7D3", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ], "pmid": "" }, { "name": "negative regulation of canonical NF-kappaB signal transduction", "id": "GO:0043124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043124", "evidence": [ { "database": "UniProtKB", "id": "E1B7D3", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "E1B7D3", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ], "pmid": "" }, { "name": "negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0032435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032435", "evidence": [ { "database": "UniProtKB", "id": "E1B7D3", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ], "pmid": "" }, { "name": "mitotic G2 DNA damage checkpoint signaling", "id": "GO:0007095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007095", "evidence": [ { "database": "UniProtKB", "id": "E1B7D3", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ], "pmid": "" }, { "name": "regulation of cell cycle G1/S phase transition", "id": "GO:1902806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902806", "evidence": [ { "database": "UniProtKB", "id": "E1B7D3", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" }, { "start_pos": 443, "end_pos": 445, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983140" } ] }, { "id": "R-BTA-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1A4I9-1", "E1BJS7-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q1JQA1-1", "Q29RQ5-1", "Q32LN5-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0AAA9RXI4-1", "Q4U5R4-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983147" } ] }, { "id": "R-BTA-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983156" } ] }, { "id": "R-BTA-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1MAR8", "gene_name": "UBE2E1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] } ] }, { "uniprot_ac": "A0A3Q1MLB6", "gene_name": "UBE2R2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] } ] }, { "uniprot_ac": "A0A3Q1MLH2", "gene_name": "RNF144B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] } ] }, { "uniprot_ac": "A0A3Q1N3G7", "gene_name": "TRIM36", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] } ] }, { "uniprot_ac": "A0AAA9RXI4", "gene_name": "MGRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] } ] }, { "uniprot_ac": "A0AAA9RXX2", "gene_name": "RBBP6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] } ] }, { "uniprot_ac": "A0AAA9RZ14", "gene_name": "ITCH", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] } ] }, { "uniprot_ac": "A0AAA9S100", "gene_name": "MKRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] } ] }, { "uniprot_ac": "A0AAA9TKS8", "gene_name": "RNF217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] } ] }, { "uniprot_ac": "A0AAA9TWH7", "gene_name": "SMURF2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] } ] }, { "uniprot_ac": "A0AAF6DMH9", "gene_name": "RNF130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] } ] }, { "uniprot_ac": "A0ABI0NWC8", "gene_name": "UBE2Q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] } ] }, { "uniprot_ac": "A0JN74", "gene_name": "TRIM11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] } ] }, { "uniprot_ac": "A1A4I9", "gene_name": "UFL1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "A1A4I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I9" } ] } ] }, { "uniprot_ac": "A3KN22", "gene_name": "UBE2M", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] } ] }, { "uniprot_ac": "A5D7F8", "gene_name": "SH3RF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] } ] }, { "uniprot_ac": "A5PJC4", "gene_name": "UBE2L6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] } ] }, { "uniprot_ac": "A5PKG6", "gene_name": "UBE4A", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] } ] }, { "uniprot_ac": "A6H795", "gene_name": "UBE2W", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] } ] }, { "uniprot_ac": "E1B782", "gene_name": "HERC2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] } ] }, { "uniprot_ac": "E1B7D3", "gene_name": "TRIM39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] } ] }, { "uniprot_ac": "E1B7G3", "gene_name": "STUB1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] } ] }, { "uniprot_ac": "E1B7Q7", "gene_name": "TRIP12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] } ] }, { "uniprot_ac": "E1B8R6", "gene_name": "ARIH2", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] } ] }, { "uniprot_ac": "E1BAV2", "gene_name": "HERC4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] } ] }, { "uniprot_ac": "E1BBN5", "gene_name": "MIB2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] } ] }, { "uniprot_ac": "E1BBY2", "gene_name": "TRIM41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] } ] }, { "uniprot_ac": "E1BCU1", "gene_name": "UBE3B", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] } ] }, { "uniprot_ac": "E1BCW1", "gene_name": "UBR2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] } ] }, { "uniprot_ac": "E1BH71", "gene_name": "DTX3L", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] } ] }, { "uniprot_ac": "E1BID7", "gene_name": "TRIM69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] } ] }, { "uniprot_ac": "E1BIP5", "gene_name": "RNF19A", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] } ] }, { "uniprot_ac": "E1BIW0", "gene_name": "UBR1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] } ] }, { "uniprot_ac": "E1BJS7", "gene_name": "TRIM71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] } ] }, { "uniprot_ac": "E1BL26", "gene_name": "RNF123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] } ] }, { "uniprot_ac": "E1BNQ6", "gene_name": "TRIM50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] } ] }, { "uniprot_ac": "E1BNY9", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] } ] }, { "uniprot_ac": "F1MBM6", "gene_name": "SIAH2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] } ] }, { "uniprot_ac": "F1MEX6", "gene_name": "RNF19B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] } ] }, { "uniprot_ac": "F1MJ10", "gene_name": "NEDD4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] } ] }, { "uniprot_ac": "F1MJS5", "gene_name": "HECTD3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] } ] }, { "uniprot_ac": "F1MLS5", "gene_name": "SMURF1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] } ] }, { "uniprot_ac": "F1MM41", "gene_name": "ZNRF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] } ] }, { "uniprot_ac": "F1MTS8", "gene_name": "LTN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] } ] }, { "uniprot_ac": "F1MWS4", "gene_name": "RNF25", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] } ] }, { "uniprot_ac": "F1MYL0", "gene_name": "RNF220", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] } ] }, { "uniprot_ac": "F1N1X8", "gene_name": "UBE2Z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] } ] }, { "uniprot_ac": "F1N3I3", "gene_name": "UBE2O", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] } ] }, { "uniprot_ac": "F1N495", "gene_name": "AREL1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] } ] }, { "uniprot_ac": "F1N5G3", "gene_name": "SIAH1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] } ] }, { "uniprot_ac": "F1N645", "gene_name": "HECW2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] } ] }, { "uniprot_ac": "F1N6G5", "gene_name": "HACE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] } ] }, { "uniprot_ac": "F1N703", "gene_name": "UBE3C", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] } ] }, { "uniprot_ac": "F1N7A0", "gene_name": "HECTD2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] } ] }, { "uniprot_ac": "P61085", "gene_name": "UBE2K", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] } ] }, { "uniprot_ac": "Q0II22", "gene_name": "RNF126", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] } ] }, { "uniprot_ac": "Q0P5K3", "gene_name": "UBE2N", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] } ] }, { "uniprot_ac": "Q17QG5", "gene_name": "UBE2G2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] } ] }, { "uniprot_ac": "Q1JQA1", "gene_name": "UBE3D", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] } ] }, { "uniprot_ac": "Q1RML1", "gene_name": "UBE2S", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] } ] }, { "uniprot_ac": "Q1RMW1", "gene_name": "UBE2F", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] } ] }, { "uniprot_ac": "Q1RMX2", "gene_name": "UBE2D2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] } ] }, { "uniprot_ac": "Q29RQ5", "gene_name": "TRIM9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] } ] }, { "uniprot_ac": "Q2T9X7", "gene_name": "UBE2E3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] } ] }, { "uniprot_ac": "Q2TA03", "gene_name": "UBE2J2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] } ] }, { "uniprot_ac": "Q2TA10", "gene_name": "UBE2D1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating 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= [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] } ] }, { "uniprot_ac": "Q32LN1", "gene_name": "UBE2H", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] } ] }, { "uniprot_ac": "Q32LN5", "gene_name": "RNF138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] } ] }, { "uniprot_ac": "Q32P99", "gene_name": "UBE2B", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] } ] }, { "uniprot_ac": "Q32PA5", "gene_name": "UBE2C", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] } ] }, { "uniprot_ac": "Q3MHP1", "gene_name": "UBE2L3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] } ] }, { "uniprot_ac": "Q4U5R4", "gene_name": "RNF114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] } ] }, { "uniprot_ac": "Q5E9J6", "gene_name": "RNF34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] } ] }, { "uniprot_ac": "Q7YRV4", "gene_name": "TRIM21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRV4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": 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gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.", "evidence": [ { "database": "UniProtKB", "id": "E1B7M7", "url": "https://www.uniprot.org/uniprotkb/E1B7M7#function" }, { "database": "UniProtKB", "id": "ARBA00002588", "url": "https://www.uniprot.org/uniprotkb/ARBA00002588#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7M7", "url": "https://www.uniprot.org/uniprotkb/E1B7M7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "INHBC", "url": "https://www.uniprot.org/uniprotkb/E1B7M7", "locus": { "chromosome": "5", "start_pos": 56010446, "end_pos": 56022009, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019084", "url": "https://www.ensembl.org/id/ENSBTAG00000019084" } ] } } ], "crossref": [ { "id": "E1B7M7", "url": "https://alphafold.ebi.ac.uk/entry/E1B7M7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019084", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019084", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19406", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19406", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "530785", "url": "https://www.ncbi.nlm.nih.gov/gene/530785", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001318", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001318", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001839", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001839", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015615", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015615", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017948", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017948", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530785", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530785", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GIDCQGG", "url": "https://omabrowser.org/oma/group/GIDCQGG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7M7", "url": "https://www.orthodb.org/?gene=E1B7M7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11848", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11848", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11848:SF130", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11848:SF130", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00019", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00019", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-209822", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-209822", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192912", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B7M7", "url": "https://www.uniprot.org/uniprotkb/E1B7M7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7M7-1", "url": "https://www.uniprot.org/uniprotkb/E1B7M7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MICSLFLAFLVLAAAMVATPRADRQCPACGEPALDVESHRELLLNLAKRSILDKLHLSQRPTLGRPVSGVALRAALHRLHGPPQGALPEADEGQEYEIISFAETGLCNTTQTRLDFHFSSDSSAGGLEVQQASLMFFVQLPPNTTCPLKVRVLELSPRDTNLTSATQHLLQVDDTGWHQLLLGPEAQTAYSQGHLALELAPEEQVDWSPVVLARAAHRPFVTARVRVGGQHRVRRRGIDCQGRSKMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCTGQCPLHVAGMPGIAASFYTSVLNLLKVNTAAGTTRGSSCCVPTVRRPLSLLYYDRDSNIVKTDIPDMVVEACGCS", "length": 352, "header": "tr|E1B7M7-1|E1B7M7_BOVIN Isoform 1 of Inhibin subunit beta C OS=Bos taurus OX=9913 GN=INHBC PE=3 SV=3 CANONICAL=E1B7M7-1" }, "isoforms": [ { "isoform_ac": "E1B7M7-1", "url": "https://www.uniprot.org/uniprotkb/E1B7M7/entry#E1B7M7-1", "sequence": { "sequence": "MICSLFLAFLVLAAAMVATPRADRQCPACGEPALDVESHRELLLNLAKRSILDKLHLSQRPTLGRPVSGVALRAALHRLHGPPQGALPEADEGQEYEIISFAETGLCNTTQTRLDFHFSSDSSAGGLEVQQASLMFFVQLPPNTTCPLKVRVLELSPRDTNLTSATQHLLQVDDTGWHQLLLGPEAQTAYSQGHLALELAPEEQVDWSPVVLARAAHRPFVTARVRVGGQHRVRRRGIDCQGRSKMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCTGQCPLHVAGMPGIAASFYTSVLNLLKVNTAAGTTRGSSCCVPTVRRPLSLLYYDRDSNIVKTDIPDMVVEACGCS", "length": 352, "header": "tr|E1B7M7-1|E1B7M7_BOVIN Isoform 1 of Inhibin subunit beta C OS=Bos taurus OX=9913 GN=INHBC PE=3 SV=3 CANONICAL=E1B7M7-1" }, "locus": { "chromosome": "5", "start_pos": 56021810, "end_pos": 56011450, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025401.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025401.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025401.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025401.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:530785", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530785", "resource": "KEGG Pathway" }, { "id": "R-BTA-209822", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-209822", "resource": "Reactome", "description": "Glycoprotein hormones" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZIJ6-1", "protein_name": "Inhibin subunit beta C", "gene_name": "INHBC", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAMISSLLLAFLFLAPATVATPQADSQCLACGGPTLDLESQRDLLLNLAKRSILDKLHLTQRPTLSRPVSRAALRTALQGLHGPPQGVLPEADRAQEYEIISFAETGLSNIDQTRLDFHFPSDRTSGSLEVQQASLMFFVQLPPNATWTLKVRVLELGPHGTNLTLATQHPLEVNNSGWHQLLLGPEAEAAYSQGHLILELVPEGQVAWNSVILDGAAHRPFVTARVRVGGKHRVRRRGIDCQGRSRMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCTGHCPLHVAGVPGIAASFHTAVLNLLKANTAAGTTGGGSCCVPTARRPLSLLYYDKDSNIVKTDIPDMVVEACGCS", "length": 354 }, "evidence": [ { "id": "E1B7M7", "url": "https://omabrowser.org/oma/group/E1B7M7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HW40-1", "protein_name": "Inhibin beta C chain", "gene_name": "Inhbc", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTSSLVLVFLLLTPATVANLQTVGPCPACWGATSDLESQRELLLDLAKKSILNKLQLSQRPTLSRPVSRAALKTALQRLRGPRQQETLMEHDQTQEYDVISFAETGLSSVNQTRLDFHFSDRMAGGIEVRQAHLMFFVQLPSNATQAMNIRVLVLRPYDTNLTLTSQYPLQVDASGWYQLLLGPEAQAACSQGHLTLELVTESQAAHRSVILGGFSHRPFVAARVRAGHKHRVHRRGIDCQRGSRMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCTGQCPLHVAGMPGISASFHTAVLNLLKANTAAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGCS", "length": 352 }, "evidence": [ { "id": "E1B7M7", "url": "https://omabrowser.org/oma/group/E1B7M7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P55103-1", "protein_name": "Inhibin beta C chain", "gene_name": "INHBC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTSSLLLAFLLLAPTTVATPRAGGQCPACGGPTLELESQRELLLDLAKRSILDKLHLTQRPTLNRPVSRAALRTALQHLHGVPQGALLEDNREQECEIISFAETGLSTINQTRLDFHFSSDRTAGDREVQQASLMFFVQLPSNTTWTLKVRVLVLGPHNTNLTLATQYLLEVDASGWHQLPLGPEAQAACSQGHLTLELVLEGQVAQSSVILGGAAHRPFVAARVRVGGKHQIHRRGIDCQGGSRMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKANTAAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGCS", "length": 352 }, "evidence": [ { "id": "E1B7M7", "url": "https://omabrowser.org/oma/group/E1B7M7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P55104-1", "protein_name": "Inhibin beta C chain", "gene_name": "Inhbc", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASSLLLALLFLTPTTVVNPKTEGPCPACWGAIFDLESQRELLLDLAKKSILDKLHLSQRPILSRPVSRGALKTALQRLRGPRRETLLEHDQRQEEYEIISFADTDLSSINQTRLEFHFSGRMASGMEVRQTRFMFFVQFPHNATQTMNIRVLVLRPYDTNLTLTSQYVVQVNASGWYQLLLGPEAQAACSQGHLTLELVPESQVAHSSLILGWFSHRPFVAAQVRVEGKHRVRRRGIDCQGASRMCCRQEFFVDFREIGWNDWIIQPEGYAMNFCTGQCPLHVAGMPGISASFHTAVLNLLKANAAAGTTGRGSCCVPTSRRPLSLLYYDRDSNIVKTDIPDMVVEACGCS", "length": 352 }, "evidence": [ { "id": "E1B7M7", "url": "https://omabrowser.org/oma/group/E1B7M7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9WUK5-1", "protein_name": "Inhibin beta C chain", "gene_name": "Inhbc", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASSLLLALLFLTLATVVNLKTDGPCPACWGATFDLESHRELLLDLAKKSILDKLHLSQRPILSRPVSREALKTALRRLRGTRAETLLEHDQRQEYEIISFADTGLSNINQTRLEFHFSDRTTGGVEVLQTRFMFFMQLPPNTTQTMNIRVLVLRPYDTNLTLTSQYMLQVDASGWYQLLLGPEAQAACSQGHLTLELVPESQLAHSSLILDGVSHRPFVAAQVRVEGKHRVRRRGINCQGLSRMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCTGQCPLHVAGMPGISASFHTAVLNLLKANTDAGTARRGSCCVPTSRRPLSLLYYDRDSNIVKTDIPDMVVEACGCS", "length": 351 }, "evidence": [ { "id": "E1B7M7", "url": "https://omabrowser.org/oma/group/E1B7M7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1B7M7", "url": "https://www.uniprot.org/uniprotkb/E1B7M7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "E1B7M7", "url": "https://www.uniprot.org/uniprotkb/E1B7M7" } ], "pmid": "" }, { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "E1B7M7", "url": "https://www.uniprot.org/uniprotkb/E1B7M7" } ], "pmid": "" }, { "name": "growth factor activity", "id": "GO:0008083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008083", "evidence": [ { "database": "UniProtKB", "id": "E1B7M7", "url": "https://www.uniprot.org/uniprotkb/E1B7M7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell surface receptor protein serine/threonine kinase signaling pathway", "id": "GO:0007178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007178", "evidence": [ { "database": "UniProtKB", "id": "E1B7M7", "url": "https://www.uniprot.org/uniprotkb/E1B7M7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 143, "end_pos": 145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7M7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 352, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7M7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7M7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7M7" }, { "id": "PS51362", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51362" } ], "ann_type": 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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"total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B7N2-1", "uniprot_ac": "E1B7N2", "uniprot_id": "E1B7N2_BOVIN", "mass": { "chemical_mass": 11777.0, "monoisotopic_mass": 11777.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Histone H4", "type": "recommended", "evidence": [ { 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Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.", "evidence": [ { "database": "UniProtKB", "id": "E1B7N2", "url": "https://www.uniprot.org/uniprotkb/E1B7N2#function" }, { "database": "UniProtKB", "id": "RU000528", "url": "https://www.uniprot.org/uniprotkb/RU000528#function" }, { "database": "UniProtKB", "id": "ARBA00002001", "url": "https://www.uniprot.org/uniprotkb/ARBA00002001#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7N2", "url": "https://www.uniprot.org/uniprotkb/E1B7N2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/E1B7N2", "locus": {} } ], "crossref": [ { "id": "E1B7N2", "url": 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"sequence": { "sequence": "MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVNRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYVLNPSSE", "length": 106, "header": "tr|E1B7N2-1|E1B7N2_BOVIN Isoform 1 of Histone H4 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=E1B7N2-1" }, "isoforms": [ { "isoform_ac": "E1B7N2-1", "url": "https://www.uniprot.org/uniprotkb/E1B7N2/entry#E1B7N2-1", "sequence": { "sequence": "MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVNRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYVLNPSSE", "length": 106, "header": "tr|E1B7N2-1|E1B7N2_BOVIN Isoform 1 of Histone H4 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=E1B7N2-1" }, "locus": { "chromosome": "6", "start_pos": 65421228, "end_pos": 65420911, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013453.4", "url": "https://www.ensembl.org/id/ENSBTAT00000013453.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013453.3", "url": "https://www.ensembl.org/id/ENSBTAP00000013453.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:619094", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:619094", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P59259-1", "protein_name": "Histone H4", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKIFLENVIRDAVTYTEHARRKTVTAMDVVYALKRQGRTLYGFGG", "length": 103 }, "evidence": [ { "id": "E1B7N2", "url": "https://omabrowser.org/oma/group/E1B7N2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P62801-1", "protein_name": "Histone H4", "gene_name": "H4-I", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG", "length": 103 }, "evidence": [ { "id": "E1B7N2", "url": "https://omabrowser.org/oma/group/E1B7N2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P62804-1", "protein_name": "Histone H4", "gene_name": "H4c16", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG", "length": 103 }, "evidence": [ { "id": "E1B7N2", "url": "https://omabrowser.org/oma/group/E1B7N2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P62805-1", "protein_name": "Histone H4", "gene_name": "H4C16", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG", "length": 103 }, "evidence": [ { "id": "E1B7N2", "url": "https://omabrowser.org/oma/group/E1B7N2/", "database": "OMA" } ], 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{ "uniprot_canonical_ac": "E1B7N3-1", "uniprot_ac": "E1B7N3", "uniprot_id": "E1B7N3_BOVIN", "mass": { "chemical_mass": 33631.0, "monoisotopic_mass": 33631.0 }, "refseq": { "ac": "XP_002685353", "name": "homeobox protein Hox-D1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685353" }, "gene_names": [ { "name": "HOXD1", "type": "recommended", "evidence": [ { "id": "E1B7N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7N3" } ] }, { "name": "HOXD1", "type": "synonym", "evidence": [ { "id": "XP_002685353", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685353" } ] } ], "protein_names": [ { "name": "Homeobox protein Hox-D1", "type": "recommended", "evidence": [ { "id": "E1B7N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7N3/entry#names_and_taxonomy" } ] }, { "name": "homeobox protein Hox-D1", "type": "synonym", "evidence": [ { "id": "XP_002685353", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685353" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7N3", "url": "https://www.uniprot.org/uniprotkb/E1B7N3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HOXD1", "url": "https://www.uniprot.org/uniprotkb/E1B7N3", "locus": { "chromosome": "2", "start_pos": 20724031, "end_pos": 20726490, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015840", "url": "https://www.ensembl.org/id/ENSBTAG00000015840" } ] } } ], "crossref": [ { "id": "E1B7N3", "url": "https://alphafold.ebi.ac.uk/entry/E1B7N3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015840", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015840", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100295780", "url": "https://www.ncbi.nlm.nih.gov/gene/100295780", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020479", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020479", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046327", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046327", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100295780", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100295780", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GPAYDFP", "url": "https://omabrowser.org/oma/group/GPAYDFP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7N3", "url": "https://www.orthodb.org/?gene=E1B7N3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45946", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45946", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45946:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45946:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002685353", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685353", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B7N3", "url": "https://www.uniprot.org/uniprotkb/E1B7N3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7N3-1", "url": "https://www.uniprot.org/uniprotkb/E1B7N3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSYLDYVSCGRDGGDLLSFASKFCRADARPVVLQPAFPLGSGDGAFVSCLPLAAARAVPSPPAAPAQPPGPAAPAYAPCPLEGAYEPGAAPVQAGGEDYGLPGSAPAYDLPCALGRPADDSGAHVHYATSAVFSGGGSFLLSGQVDYAAFGEPGPFSACLKEPTDGHSGAFQTASPAPGVYPKCASPASGLPAAFSTFEWMKVKRNAPKKSKFAEYGAATPSSAIRTNFSTKQLTELEKEFHFNKYLTRARRIEIANSLQLNDTQVKIWFQNRRMKQKKREREGLLPSATPVASFQLPISGTSPAKSGKNPGSPSQAQEPS", "length": 322, "header": "tr|E1B7N3-1|E1B7N3_BOVIN Isoform 1 of Homeobox protein Hox-D1 OS=Bos taurus OX=9913 GN=HOXD1 PE=3 SV=2 CANONICAL=E1B7N3-1" }, "isoforms": [ { "isoform_ac": "E1B7N3-1", "url": "https://www.uniprot.org/uniprotkb/E1B7N3/entry#E1B7N3-1", "sequence": { "sequence": "MSSYLDYVSCGRDGGDLLSFASKFCRADARPVVLQPAFPLGSGDGAFVSCLPLAAARAVPSPPAAPAQPPGPAAPAYAPCPLEGAYEPGAAPVQAGGEDYGLPGSAPAYDLPCALGRPADDSGAHVHYATSAVFSGGGSFLLSGQVDYAAFGEPGPFSACLKEPTDGHSGAFQTASPAPGVYPKCASPASGLPAAFSTFEWMKVKRNAPKKSKFAEYGAATPSSAIRTNFSTKQLTELEKEFHFNKYLTRARRIEIANSLQLNDTQVKIWFQNRRMKQKKREREGLLPSATPVASFQLPISGTSPAKSGKNPGSPSQAQEPS", "length": 322, "header": "tr|E1B7N3-1|E1B7N3_BOVIN Isoform 1 of Homeobox protein Hox-D1 OS=Bos taurus OX=9913 GN=HOXD1 PE=3 SV=2 CANONICAL=E1B7N3-1" }, "locus": { "chromosome": "2", "start_pos": 20726338, "end_pos": 20725035, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021043.5", "url": "https://www.ensembl.org/id/ENSBTAT00000021043.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021043.3", "url": "https://www.ensembl.org/id/ENSBTAP00000021043.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 221, "start_aa": "Thr", "end_pos": 221, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr221", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100295780", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100295780", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4ACE4-1", "protein_name": "Homeobox protein Hox-D1", "gene_name": "Hoxd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSYLEYVSCAAGGGSGGVGGDVLGFAPKFCRADARPVALQPAFPLGSGDGAFVSCLPLAAARPTPSPPVAPAQPPGPQPAASRYAPCTLEGAYERGAAPASAAEYGFLGSGPAFDFPGALGRAADDSGPHVHYATSAVFSSGGSFLLSGQVDFAAFAEPGPFPACLKEPADGHPGPFQTVSPAPGACPKPASPTSGLPAAHSTFEWMKVKRNAPKKSKLSEYGATSPSSAIRTNFSTKQLTELEKEFHFNKYLTRARRMEIANCLQLNDTQVKIWFQNRRMKQKKREREGLLATAASVASLQLPGSETSPIKSGRNLGSPSQAQEPS", "length": 328 }, "evidence": [ { "id": "E1B7N3", "url": "https://omabrowser.org/oma/group/E1B7N3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RZF8-1", "protein_name": "Homeobox protein Hox-D1", "gene_name": "HOXD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSSYLDYMSCGRGRGGGGDVLSFAPKFCRADARPVVLQPALPLGSGDGAFVSCLPLAAARAAPSPPTAPAQPPAPAPAPPAYAPCPLEGAYEPGAAPAAAGGTDFGLPGPGPAYDFPCALGRPADDGGAHVHYATSAVFSGGGSFLLSGQGDYVAFGEPGPFPACLKEPADGHSGAFQTASPALGAYPTSASPASGLPAAFSTFEWMKVKRNAPKKSKLAEYGAASPPSAIRTNFSTKQLTELEKEFHFNKYLTRARRIEIANSLQLNDTQVKIWFQNRRMKQKKREREGLLLSATPVASLQLPLSGTSPIKSGKNPGSPSQAHEPS", "length": 327 }, "evidence": [ { "id": "E1B7N3", "url": "https://omabrowser.org/oma/group/E1B7N3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q01822-1", "protein_name": "Homeobox protein Hox-D1", "gene_name": "Hoxd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSYLEYVSCAAGGGSGGVGGDVLGFAPKFCRADARPVALQPAFPLGSGDGAFVSCLPLATARPTPSPPAGPAQSPVPQPAAPRYAPCTLEGAYERGAAPASAAEYGFLGSGPAFDFPGALGRAADEGGAHVHYATSAVFSGGGSFLLSGQVDFAAFGEPGPFPACLKEPADGHPGPFQTVSPAPGACPKPASPTSSLPAAHSTFEWMKVKRNAPKKSKLSEYGATSPPSAIRTNFSTKQLTELEKEFHFNKYLTRARRIEIANCLQLNDTQVKIWFQNRRMKQKKREREGLLATAASVASIKLPRSETSPIKSGRNLGSPSQAQEPS", "length": 328 }, "evidence": [ { "id": "E1B7N3", "url": "https://omabrowser.org/oma/group/E1B7N3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9GZZ0-1", "protein_name": "Homeobox protein Hox-D1", "gene_name": "HOXD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSYLEYVSCSSSGGVGGDVLSLAPKFCRSDARPVALQPAFPLGNGDGAFVSCLPLAAARPSPSPPAAPARPSVPPPAAPQYAQCTLEGAYEPGAAPAAAAGGADYGFLGSGPAYDFPGVLGRAADDGGSHVHYATSAVFSGGGSFLLSGQVDYAAFGEPGPFPACLKASADGHPGAFQTASPAPGTYPKSVSPASGLPAAFSTFEWMKVKRNASKKGKLAEYGAASPSSAIRTNFSTKQLTELEKEFHFNKYLTRARRIEIANCLHLNDTQVKIWFQNRRMKQKKREREGLLATAIPVAPLQLPLSGTTPTKFIKNPGSPSQSQEPS", "length": 328 }, "evidence": [ { "id": "E1B7N3", "url": "https://omabrowser.org/oma/group/E1B7N3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B7N3", "url": "https://www.uniprot.org/uniprotkb/E1B7N3" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1B7N3", "url": "https://www.uniprot.org/uniprotkb/E1B7N3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1B7N3", "url": "https://www.uniprot.org/uniprotkb/E1B7N3" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1B7N3", "url": "https://www.uniprot.org/uniprotkb/E1B7N3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1B7N3", "url": "https://www.uniprot.org/uniprotkb/E1B7N3" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1B7N3", "url": "https://www.uniprot.org/uniprotkb/E1B7N3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 229, "end_pos": 231, "annotation": "n_glycosylation_sequon" }, { "start_pos": 263, "end_pos": 265, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7N3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 322, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7N3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7N3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7N3" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 221, "end_pos": 281, "start_aa": "Thr", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 221 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 229, "end_pos": 231 }, { "start_pos": 263, "end_pos": 265 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B7Q8-1", "uniprot_ac": "E1B7Q8", "uniprot_id": "E1B7Q8_BOVIN", "mass": { "chemical_mass": 63328.0, "monoisotopic_mass": 63328.0 }, "refseq": {}, "gene_names": [ { "name": "PTH2R", "type": "recommended", "evidence": [ { "id": "E1B7Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q8" } ] } ], "protein_names": [ { "name": "Parathyroid hormone 2 receptor", "type": "recommended", "evidence": [ { "id": "E1B7Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q8", "url": "https://www.uniprot.org/uniprotkb/E1B7Q8#function" }, { "database": "UniProtKB", "id": "ARBA00053481", "url": "https://www.uniprot.org/uniprotkb/ARBA00053481#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7Q8", "url": "https://www.uniprot.org/uniprotkb/E1B7Q8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTH2R", "url": "https://www.uniprot.org/uniprotkb/E1B7Q8", "locus": { "chromosome": "2", "start_pos": 96752724, "end_pos": 96667562, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011992", "url": "https://www.ensembl.org/id/ENSBTAG00000011992" } ] } } ], "crossref": [ { "id": "E1B7Q8", "url": "https://alphafold.ebi.ac.uk/entry/E1B7Q8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011992", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011992", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15982", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15982", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017981", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017981", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VDHWNKT", "url": "https://omabrowser.org/oma/group/VDHWNKT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7Q8", "url": "https://www.orthodb.org/?gene=E1B7Q8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45620", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45620", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45620:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45620:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00002", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00002", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02793", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02793", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-373080", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373080", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1B7Q8", "url": "https://www.uniprot.org/uniprotkb/E1B7Q8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7Q8-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Q8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFQFLARAGLGMAGPGASLHFWGWLLLGCCILAGAQLDSDGTITIEEQIVLVLKAKVQCELNITAQLQEGEGNCFPEWDGLICWPRGTVGKTLAVPCPPYIYDFNHKGVAFRHCNPNGTWDFMHSLNKTWSNYSDCLRFLQPDINIGKQEFFERLYVMYTIGYSVSFASLAVAILIIGYFRRLHCTRNYIHMHLFVSFMLRAASIFVKDGVVHAHIGVKELRSLILQDDLQSSIEVPAVDKSQYIGCKMAVVMFIYFLATNYYWILVEGLYLHSLIFVAFFSDTKYLWGFTLIGWGFPAAFVTVWAVARATLADARCWELSAGDIKWIYQAPILAAIGLNFILFLNTVRVLATKIWETNVVGHDTRKQYRKLAKSTLVLVLVFGVHYIVFVCLPHSFAGLGWEIRMHCELFFNSFQGFFVSIIYCYCNGEVQSEVKKLWSRWNLSVDWKRTPPCGGHRYGSVLTTLTHSTSSQSQMAASTRMGLISGKAPRKASRQPDNHMTLPGYVWSNSEQDCLPQLIHEETKESGGRQGDEIIMEESSRPLEFSTGLEGSKGETEDAL", "length": 561, "header": "tr|E1B7Q8-1|E1B7Q8_BOVIN Isoform 1 of Parathyroid hormone 2 receptor OS=Bos taurus OX=9913 GN=PTH2R PE=3 SV=2 CANONICAL=E1B7Q8-1" }, "isoforms": [ { "isoform_ac": "E1B7Q8-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Q8/entry#E1B7Q8-1", "sequence": { "sequence": "MFQFLARAGLGMAGPGASLHFWGWLLLGCCILAGAQLDSDGTITIEEQIVLVLKAKVQCELNITAQLQEGEGNCFPEWDGLICWPRGTVGKTLAVPCPPYIYDFNHKGVAFRHCNPNGTWDFMHSLNKTWSNYSDCLRFLQPDINIGKQEFFERLYVMYTIGYSVSFASLAVAILIIGYFRRLHCTRNYIHMHLFVSFMLRAASIFVKDGVVHAHIGVKELRSLILQDDLQSSIEVPAVDKSQYIGCKMAVVMFIYFLATNYYWILVEGLYLHSLIFVAFFSDTKYLWGFTLIGWGFPAAFVTVWAVARATLADARCWELSAGDIKWIYQAPILAAIGLNFILFLNTVRVLATKIWETNVVGHDTRKQYRKLAKSTLVLVLVFGVHYIVFVCLPHSFAGLGWEIRMHCELFFNSFQGFFVSIIYCYCNGEVQSEVKKLWSRWNLSVDWKRTPPCGGHRYGSVLTTLTHSTSSQSQMAASTRMGLISGKAPRKASRQPDNHMTLPGYVWSNSEQDCLPQLIHEETKESGGRQGDEIIMEESSRPLEFSTGLEGSKGETEDAL", "length": 561, "header": "tr|E1B7Q8-1|E1B7Q8_BOVIN Isoform 1 of Parathyroid hormone 2 receptor OS=Bos taurus OX=9913 GN=PTH2R PE=3 SV=2 CANONICAL=E1B7Q8-1" }, "locus": { "chromosome": "2", "start_pos": 96751780, "end_pos": 96667717, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061196.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061196.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053185.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053185.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-373080", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373080", "resource": "Reactome", "description": "Class B/2 (Secretin family receptors)" }, { "id": "R-BTA-418555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "resource": "Reactome", "description": "G alpha (s) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SST8-1", "protein_name": "Parathyroid hormone 2 receptor", "gene_name": "PTH2R", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARSGASLHLWGWVLLGGCLLAGAQLDSDGTITIEEQIVLVLKAKMQCELNITAQLQEGEGNCFPEWDGLICWPRGTVGKMSAVPCPSYIYDFNHKGVAFRHCNPNGTWDFMHGLNKTWANYSDCLRFLQPDISIGKQEFFERLYIMYTIGYSISFGSLAVAILIIGYFRRLHCTRNYIHMHLFVSFMLRAASIFVKDKVVHAHIGVKELQSLIMQGNLQSSIELPSVDKSQYIGCKIAVVMFIYFLATNYYWILVEGLYLHSLIFVAFFSDTKYLWGFTLIGWGFPAAFVTAWAAARATLADERCWELSAGDIKWIYQAPILAAIGLNFILFLNTVRVLATKIWETNAVGHDTRKQYRKLAKSTLVLVLVFGVHYIVFVCLPHSFAGLGWEIRMHCELFFNSFQGFFVSIIYCYGNGEVQSEVKKMWSRWNLSVDWKRTPPCGGHRYGSVLTTLTHSTSSQSQMAASTRSVLISGKAAKTAGPQPDSHVTLPGYVWSNSEQDCLPHLIHEEAQESNGRQGDEIPMEESSRRLDFNLDPEGGKGETEDAL", "length": 550 }, "evidence": [ { "id": "E1B7Q8", "url": "https://omabrowser.org/oma/group/E1B7Q8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P49190-1", "protein_name": "Parathyroid hormone 2 receptor", "gene_name": "PTH2R", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGLGASLHVWGWLMLGSCLLARAQLDSDGTITIEEQIVLVLKAKVQCELNITAQLQEGEGNCFPEWDGLICWPRGTVGKISAVPCPPYIYDFNHKGVAFRHCNPNGTWDFMHSLNKTWANYSDCLRFLQPDISIGKQEFFERLYVMYTVGYSISFGSLAVAILIIGYFRRLHCTRNYIHMHLFVSFMLRATSIFVKDRVVHAHIGVKELESLIMQDDPQNSIEATSVDKSQYIGCKIAVVMFIYFLATNYYWILVEGLYLHNLIFVAFFSDTKYLWGFILIGWGFPAAFVAAWAVARATLADARCWELSAGDIKWIYQAPILAAIGLNFILFLNTVRVLATKIWETNAVGHDTRKQYRKLAKSTLVLVLVFGVHYIVFVCLPHSFTGLGWEIRMHCELFFNSFQGFFVSIIYCYCNGEVQAEVKKMWSRWNLSVDWKRTPPCGSRRCGSVLTTVTHSTSSQSQVAASTRMVLISGKAAKIASRQPDSHITLPGYVWSNSEQDCLPHSFHEETKEDSGRQGDDILMEKPSRPMESNPDTEGCQGETEDVL", "length": 550 }, "evidence": [ { "id": "E1B7Q8", "url": "https://omabrowser.org/oma/group/E1B7Q8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P70555-1", "protein_name": "Parathyroid hormone 2 receptor", "gene_name": "Pth2r", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPWLEALPYICGWLILRSCLLVGAQLDSDGTITIEEQIVLVMKAKMQCELNITAQFQEGEGNCFPEWDGLICWPRGTAGKTSAMPCPSYVYDFNHKGVAFRHCTPNGTWDFIHGSNKTWANYSDCFLQPDINIGKQEFFENLYILYTVGYSISFGSLAVAILIIGYFRRLHCTRNYIHLHLFVSFMLRAXSIFVKDRVAQAHLGVEALQSLVMQGDLQNFIGGPSVDKSQYVGCKIAVVMFIYFLATNYYWILVEGLYLHNLIFVSFFSDTKYLWGFILIGWGFPAVFVVAWAVARATLADTRCWELSAGDRWIYXXPILAAIGLNFILFLNTVRVLATKIWETNAVGHDMRKQYRKLAKSTLVLVLVFGVHYIVFICQPHSFSGLWWEIRMHCELFFNSFQGFFVSIVYCYCNGEVQAEVKKTWTRWNLSIDWKKAPPCGGHRYGSVLTTVTHSTSSQSQMGPSTRLVLISSKPAKTACRQIDSHVTLPGYVWSSSEQDCQPQSTPEETKKGHGRQEDDSPVGESSRPVAFTIDTEGCKGESHPI", "length": 546 }, "evidence": [ { "id": "E1B7Q8", "url": "https://omabrowser.org/oma/group/E1B7Q8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91V95-1", "protein_name": "Parathyroid hormone 2 receptor", "gene_name": "Pth2r", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAWLETFTYICGWLILSSCLLVRAQLDSDGTITIEEQIVLVMKAKMQCELNITAQLQEGEGNCFPEWDGIICWPRGTVGKMSAVPCPPYVYDFNHKGVAFRHCTPNGTWDSIHGSNKTWANYSDCFLQPDINIGKQEFFESLYILYTVGYSISFGSLAVAILIIGYFRRLHCTRNYIHLHLFVSFMLRAMSIFVKDRVAQAHLGVEALQSLVMQGDLQNFIGGPSVDKSQYVGCKIAVVMFIYFLATNYYWILVEGLYLHNLIFVSFFSDTKYLWGFISIGWGFPAVFVVAWAVARATLADTRCWELSAGDRWIYQAPILAAIGLNFILFLNTVRVLATKIWETNAVGHDMRKQYRKLAKSTLVLVLVFGVHYIVFVCQPHSFSGLWWEIRMHCELFFNSFQGFFVSIVYCYCNGEVQAEVKKMWTRWNLSIDWKRAPPCGGQRYGSVLTTVTHSTSSQSQMGASTRLVLISGKPTKNACRQIDSHVTLPGYVWSSSEQDCQTHSPPEETKEGHRRQGDDSPVMESSRPVAFTLDTEGCKGETHPI", "length": 546 }, "evidence": [ { "id": "E1B7Q8", "url": "https://omabrowser.org/oma/group/E1B7Q8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q8", "url": "https://www.uniprot.org/uniprotkb/E1B7Q8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q8", "url": "https://www.uniprot.org/uniprotkb/E1B7Q8" } ], "pmid": "" }, { "name": "adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "id": "GO:0007188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007188", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q8", "url": "https://www.uniprot.org/uniprotkb/E1B7Q8" } ], "pmid": "" }, { "name": "positive regulation of cold-induced thermogenesis", "id": "GO:0120162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120162", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q8", "url": "https://www.uniprot.org/uniprotkb/E1B7Q8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "peptide hormone binding", "id": "GO:0017046", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017046", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q8", "url": "https://www.uniprot.org/uniprotkb/E1B7Q8" } ], "pmid": "" }, { "name": "G protein-coupled peptide receptor activity", "id": "GO:0008528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008528", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q8", "url": "https://www.uniprot.org/uniprotkb/E1B7Q8" } ], "pmid": "" }, { "name": "parathyroid hormone receptor activity", "id": "GO:0004991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004991", "evidence": [ { "database": "UniProtKB", "id": "E1B7Q8", "url": "https://www.uniprot.org/uniprotkb/E1B7Q8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" }, { "start_pos": 443, "end_pos": 445, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7Q8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 561, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7Q8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7Q8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q8" }, { "id": "PS50227", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50227" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 2 profile 1", "eco_id": "ECO_0000259", "start_pos": 58, "end_pos": 140, "start_aa": "Gln", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B7Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q8" }, { "id": "PS50261", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50261" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 2 profile 2", "eco_id": "ECO_0000259", "start_pos": 155, "end_pos": 428, "start_aa": "Leu", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 117, "end_pos": 119 }, { "start_pos": 127, "end_pos": 129 }, { "start_pos": 132, "end_pos": 134 }, { "start_pos": 443, "end_pos": 445 }, { "start_pos": 62, "end_pos": 64 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B7S1-1", "uniprot_ac": "E1B7S1", "uniprot_id": "E1B7S1_BOVIN", "mass": { "chemical_mass": 79435.0, "monoisotopic_mass": 79435.0 }, "refseq": { "ac": "XP_005205890", "name": "protein mono-ADP-ribosyltransferase PARP12 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205890" }, "gene_names": [ { "name": "PARP12", "type": "recommended", "evidence": [ { "id": "E1B7S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S1" } ] }, { "name": "PARP12", "type": "synonym", "evidence": [ { "id": "XP_005205890", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205890" } ] } ], "protein_names": [ { "name": "Poly(ADP-ribose) polymerase family member 12", "type": "synonym", "evidence": [ { "id": "E1B7S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S1/entry#names_and_taxonomy" } ] }, { "name": "protein mono-ADP-ribosyltransferase PARP12 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005205890", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205890" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7S1", "url": "https://www.uniprot.org/uniprotkb/E1B7S1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PARP12", "url": "https://www.uniprot.org/uniprotkb/E1B7S1", "locus": { "chromosome": "4", "start_pos": 103472246, "end_pos": 103518399, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016546", "url": "https://www.ensembl.org/id/ENSBTAG00000016546" } ] } } ], "crossref": [ { "id": "E1B7S1", "url": "https://alphafold.ebi.ac.uk/entry/E1B7S1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016546", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016546", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01439", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01439", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513185", "url": "https://www.ncbi.nlm.nih.gov/gene/513185", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000571", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000571", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037197", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051712", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051712", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056226", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056226", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057602", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057602", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "WKDLDNM", "url": "https://omabrowser.org/oma/group/WKDLDNM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7S1", "url": "https://www.orthodb.org/?gene=E1B7S1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45740", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45740", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45740:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45740:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00644", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00644", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02825", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02825", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23466", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23466", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24356", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24356", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25261", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25261", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005205890", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205890", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B7S1", "url": "https://www.uniprot.org/uniprotkb/E1B7S1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7S1-1", "url": "https://www.uniprot.org/uniprotkb/E1B7S1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPAALLREVTQVLCAAGGALELEELRRRVRPNVDCDVLDRLLRERGRFLVARRAAGAGAAAVERVVLAVSPLRLCSAHLGPKPGCAGLCAQLHLCKSLFYGKCKFLRDGKDCRNGHNLMSNHNVSVLKTHGLDHLNYGELCMLLFQNDPLLLPEICLHYNKGDGPYGSCSFKKHCIKLHVCQYFSQGECKFGTGCKRSHDFSNSENLEKLEKLGMRPELVSKLPSIYRNAHDIKNKSSASIRVPPPPSQSQGTSKRRDTGSVSLNTATQEESDQICLFHIWKSCSFQDKCSRVHFHLPYRWQVLDGGKWKDLHKMELIEEAYSNPARDRVRCTETSSSFLIGFLNFETMKFGATQARRLSTASSVTKPPHFILTTNWVWYWTDEFGSWQEYGRQGMDHPVTSVTSSDLEKAYLAYCASGSNPQAATLRFQAGKHSYELDFKAFIQKNVIYGTVRKVCRRPKYVSPQDVKMKQTCSINSQGLKNIPDHWDRSALPDTGFKRITVPSSSEEFQKVWSLFTSTMPLYSIQKIERVQNPALWEIYQWQKEQMQKRNGRKMVDERQLFHGTSTGLVDAICQQNFDWRVSGLHGTSYGKGSYFARDAAYSHHYSKTDSNTHTMFLARVLVGEFVRGSTAYVRPPIKEAQGNILYDSCVNSMSEPSIFVIFEKHQAYPEYVIQYTASTKPPAATPTFFSLASFFSGRQ", "length": 702, "header": "tr|E1B7S1-1|E1B7S1_BOVIN Isoform 1 of Poly(ADP-ribose) polymerase family member 12 OS=Bos taurus OX=9913 GN=PARP12 PE=3 SV=3 CANONICAL=E1B7S1-1" }, "isoforms": [ { "isoform_ac": "E1B7S1-1", "url": "https://www.uniprot.org/uniprotkb/E1B7S1/entry#E1B7S1-1", "sequence": { "sequence": "MAPAALLREVTQVLCAAGGALELEELRRRVRPNVDCDVLDRLLRERGRFLVARRAAGAGAAAVERVVLAVSPLRLCSAHLGPKPGCAGLCAQLHLCKSLFYGKCKFLRDGKDCRNGHNLMSNHNVSVLKTHGLDHLNYGELCMLLFQNDPLLLPEICLHYNKGDGPYGSCSFKKHCIKLHVCQYFSQGECKFGTGCKRSHDFSNSENLEKLEKLGMRPELVSKLPSIYRNAHDIKNKSSASIRVPPPPSQSQGTSKRRDTGSVSLNTATQEESDQICLFHIWKSCSFQDKCSRVHFHLPYRWQVLDGGKWKDLHKMELIEEAYSNPARDRVRCTETSSSFLIGFLNFETMKFGATQARRLSTASSVTKPPHFILTTNWVWYWTDEFGSWQEYGRQGMDHPVTSVTSSDLEKAYLAYCASGSNPQAATLRFQAGKHSYELDFKAFIQKNVIYGTVRKVCRRPKYVSPQDVKMKQTCSINSQGLKNIPDHWDRSALPDTGFKRITVPSSSEEFQKVWSLFTSTMPLYSIQKIERVQNPALWEIYQWQKEQMQKRNGRKMVDERQLFHGTSTGLVDAICQQNFDWRVSGLHGTSYGKGSYFARDAAYSHHYSKTDSNTHTMFLARVLVGEFVRGSTAYVRPPIKEAQGNILYDSCVNSMSEPSIFVIFEKHQAYPEYVIQYTASTKPPAATPTFFSLASFFSGRQ", "length": 702, "header": "tr|E1B7S1-1|E1B7S1_BOVIN Isoform 1 of Poly(ADP-ribose) polymerase family member 12 OS=Bos taurus OX=9913 GN=PARP12 PE=3 SV=3 CANONICAL=E1B7S1-1" }, "locus": { "chromosome": "4", "start_pos": 103518348, "end_pos": 103473050, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022006.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022006.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022006.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022006.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 688, "start_aa": "Thr", "end_pos": 688, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr688", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "D4A3V3-1", "protein_name": "Protein mono-ADP-ribosyltransferase PARP12", "gene_name": "Parp12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQAAVAVAEVTQLLCAAGGALELAELRRRLRTSLGADALERLLRDRGRFVVASREGTGPATAAAAASERVVVAVSSLRLCRAHQGPKQGCTGLCAQLHLCKFLIYGNCKFLRTGKNCRNGHNLKTDHNLSVLRTHGIDHLTYTELCQLLLQNDPSLLPDICLHYNKGDGHFGSCSFQKQCIKLHICQYFLQGECKFGTSCKRSHEFTNSENLEKLEKLGLSSDLVSRLLSTYRNAYDIKNKGSALSKVSSSPAGPQGTSERKDSSVSPGTLSQEESEQICLYHIRKSCSFQDKCHRVHFHLPYRWQFLDGGEWKDLDNMELIENAYCNPSKDRIVYTESAAGFHFDNLDFNSMKLGHTLARRLSTASSVTKPPHFILTTEWAWYWMDEFGSWQEYGRQGTGHPVTTISSSDVEKAYLSFCVPGADAQAAILKFQAGKHNYELDFKAFLQKNLVYGTVRKVCRRPKYVSPQDVQMKQSCNTKLHGTKSIPDYWDPAALPDLGFKRITLSSSSEEYQKVWNLFNRTLPFYFVQKIERIQNLGLWEVYQWQKGQMQKQNGGKEVDERQLFHGTSTNFVDAICQQNFDWRVCGLHGTSYGKGSYFARDAAYSHHYSKSDTHSHTMFLARVLVGDFVRGSTSFVRPPAKEGQSNAFYDSCVNSMSDPTIFVVFEKHQVYPEYLIQYSTSSKPPAGPSIFVALGNLFTSRQ", "length": 706 }, "evidence": [ { "id": "E1B7S1", "url": "https://omabrowser.org/oma/group/E1B7S1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SRP3-1", "protein_name": "Poly(ADP-ribose) polymerase family member 12", "gene_name": "PARP12", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAPAALLREVTQTLCAAGGSLGLEELRRRLRPGVGGDALDRLLRECGHCVVVRRAAGAGAAAVEPSVLAASPLRLCTAHLGPKPSCHGLCAQLHLCKFVLYGQCKFLRDGKECRSSHTLRSDHNMSVLKTQGVDHLDFSELTVLLLQNDPQLLPEICLHYNKGDGPYGSCSFKKQCIKLHVCQYFSQGKCKFGTGCKRSHDFSNPENLEKLEKLGMRSDLVSRLPSIYRNAHDIKNKSSPLVRVPPPPSRSQGSSERRDTGSVCPNTAPQEESDQICLYHIWKSCSFQEKCSRVHFHLPYRWQVLDGGKWKDLPKMELIEEAYSNPRRDGITCTESAGSFPIGSLKFDSMTFGGTRARRLSTASSVTKPPHFILTTEWLWYWTDELGSWQEYGRQDMEHPVTSVNSSDLEKAYLAYCTPGSDAKAAILRFQAGKHTYELDFRAFIQKNLAYGTMRKVRRRPKYVSPQDVKMKQTCSVNFQGPKSIPEHWDHSAVPDTGFKRIALHSSSEEFQKVWNLFTCTMPNHCIQKIERVQNVALWEVYQWQKGQMQKRNGGKAVDERQLFHGTSTSLVDAICQQNFDWRVNGLHGTSYGKGSYFARDAAYSHHYSKSNTKSHTMFLARVLVGEFVRGNTSFVRPPAKEGQGTVLYDSCVNSVSDPSIFVIFEKHQAYPEYVIQYTALTKPMPAASNLLSLASLFSGRQ", "length": 702 }, "evidence": [ { "id": "E1B7S1", "url": "https://omabrowser.org/oma/group/E1B7S1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8BZ20-1", "protein_name": "Protein mono-ADP-ribosyltransferase PARP12", "gene_name": "Parp12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQAAVAVAEVTQLLCAAGGALELAELRRRLRTSLGTDALERLLRDCGRFVVASRAVVAVGAGREAAAAASERLVLAVSSLRLCRAHQGPKPGCTGLCAQLHLCKFLIYGNCKFLKTGKNCRNGHNLKTDHNLSVLRTHGVDHLTYTELCQLLLQNDPSLLPDICLHYNKGDGPFGSCSFQKQCIKLHICQYFLQGECKFGTSCKRSHEFTNSESLEQLERLGLSSDLVSRLLSTYRNAYDIKNKGSALSKVSPSPAGPQGSSERKDSSGPVSPGTPSQEESEQICLYHIRKSCSFQEKCHRVHFHLPYRWQFLDGGKWKDLDNMELIEEAYSNPSKDRIVYTESAAGFHFDNLDFNSMKFGNTLARRLSTASSVTKPPHFILTTDWIWYWMDEFGSWQEYGRQGSGHPVTTISSSDVERAYLAFCAPGADAQAATLKFQAGKHNYELHFKAFLQKNLVYGTIRKVCRRPKYVSPQDVQMKQSCNTKLHGPKSIPDYWDPAALPDLGFKKITLSSSSEEYQKVWNIFNRTLPFYFVQKIERIQNMGLWEVYQWQKCQMQKQNGGKEVDERQLFHGTSANFVDAICQQNFDWRVCGLHGTSYGKGSYFARDAAYSHHYSKSDTHSHMMFLARVLVGDFVRGSTSFVRPPAKEGQSNAFYDSCVNSMSDPTIFVVFEKHQVYPEYLIQYSTSSKPPASPSIFVALGNLFTSRQ", "length": 711 }, "evidence": [ { "id": "E1B7S1", "url": "https://omabrowser.org/oma/group/E1B7S1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H0J9-1", "protein_name": "Protein mono-ADP-ribosyltransferase PARP12", "gene_name": "PARP12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQAGVVGEVTQVLCAAGGALELPELRRRLRMGLSADALERLLRQRGRFVVAVRAGGAAAAPERVVLAASPLRLCRAHQGSKPGCVGLCAQLHLCRFMVYGACKFLRAGKNCRNSHSLTTEHNLSVLRTHGVDHLSYNELCQLLFQNDPWLLPEICQHYNKGDGPHGSCAFQKQCIKLHICQYFLQGECKFGTSCKRSHDFSNSENLEKLEKLGMSSDLVSRLPTIYRNAHDIKNKSSAPSRVPPLFVPQGTSERKDSSGSVSPNTLSQEEGDQICLYHIRKSCSFQDKCHRVHFHLPYRWQFLDRGKWEDLDNMELIEEAYCNPKIERILCSESASTFHSHCLNFNAMTYGATQARRLSTASSVTKPPHFILTTDWIWYWSDEFGSWQEYGRQGTVHPVTTVSSSDVEKAYLAYCTPGSDGQAATLKFQAGKHNYELDFKAFVQKNLVYGTTKKVCRRPKYVSPQDVTTMQTCNTKFPGPKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEVYQWQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNAFYDSCVNSVSDPSIFVIFEKHQVYPEYVIQYTTSSKPSVTPSILLALGSLFSSRQ", "length": 701 }, "evidence": [ { "id": "E1B7S1", "url": "https://omabrowser.org/oma/group/E1B7S1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "NAD+-protein mono-ADP-ribosyltransferase activity", "id": "GO:1990404", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990404", "evidence": [ { "database": "UniProtKB", "id": "E1B7S1", "url": "https://www.uniprot.org/uniprotkb/E1B7S1" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B7S1", "url": "https://www.uniprot.org/uniprotkb/E1B7S1" } ], "pmid": "" }, { "name": "NAD+ poly-ADP-ribosyltransferase activity", "id": "GO:0003950", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003950", "evidence": [ { "database": "UniProtKB", "id": "E1B7S1", "url": "https://www.uniprot.org/uniprotkb/E1B7S1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein auto-ADP-ribosylation", "id": "GO:0070213", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070213", "evidence": [ { "database": "UniProtKB", "id": "E1B7S1", "url": "https://www.uniprot.org/uniprotkb/E1B7S1" } ], "pmid": "" }, { "name": "transepithelial transport", "id": "GO:0070633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070633", "evidence": [ { "database": "UniProtKB", "id": "E1B7S1", "url": "https://www.uniprot.org/uniprotkb/E1B7S1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1B7S1", "url": "https://www.uniprot.org/uniprotkb/E1B7S1" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "E1B7S1", "url": "https://www.uniprot.org/uniprotkb/E1B7S1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 236, "end_pos": 238, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7S1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 702, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7S1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7S1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1B7S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S1" }, { "id": "PS50103", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50103" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C3H1-type", "eco_id": "ECO_0000259", "start_pos": 181, "end_pos": 203, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B7S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S1" }, { "id": "PS51059", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51059" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PARP catalytic", "eco_id": "ECO_0000259", "start_pos": 485, "end_pos": 699, "start_aa": "Ile", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "E1B7S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7S1" }, { "id": "PS50918", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50918" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WWE", "eco_id": "ECO_0000259", "start_pos": 286, "end_pos": 362, "start_aa": "Ser", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 688 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 124, "end_pos": 126 }, { "start_pos": 236, "end_pos": 238 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B7T6-1", "uniprot_ac": "E1B7T6", "uniprot_id": "E1B7T6_BOVIN", "mass": { "chemical_mass": 53524.0, "monoisotopic_mass": 53524.0 }, "refseq": {}, "gene_names": [ { "name": "MFSD2B", "type": "recommended", "evidence": [ { "id": "E1B7T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7T6" } ] } ], "protein_names": [ { "name": "Sphingosine-1-phosphate transporter MFSD2B", "type": "recommended", "evidence": [ { "id": "E1B7T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7T6/entry#names_and_taxonomy" } ] }, { "name": "Major facilitator superfamily domain-containing protein 2B", "type": "synonym", "evidence": [ { "id": "E1B7T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7T6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets. Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology. Sphingosine-1-phosphate export from platelets is required for platelet aggregation and thrombus formation. Mediates the export of different sphingosine-1-phosphate (S1P) species, including S1P(d18:0) (sphinganine 1-phosphate), S1P (d18:1) (sphing-4-enine 1-phosphate) and S1P (d18:2) (sphinga-4E,14Z-dienine-1-phosphate). Release of sphingosine-1-phosphate is facilitated by a proton gradient. In contrast, cations, such as sodium, are not required to drive sphingosine-1-phosphate transport. In addition to export, also able to mediate S1P import. Does not transport lysophosphatidylcholine (LPC).", "evidence": [ { "database": "UniProtKB", "id": "E1B7T6", "url": "https://www.uniprot.org/uniprotkb/E1B7T6#function" }, { "database": "UniProtKB", "id": "ARBA00054387", "url": "https://www.uniprot.org/uniprotkb/ARBA00054387#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7T6", "url": "https://www.uniprot.org/uniprotkb/E1B7T6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MFSD2B", "url": "https://www.uniprot.org/uniprotkb/E1B7T6", "locus": { "chromosome": "11", "start_pos": 75033972, "end_pos": 75047918, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002034", "url": "https://www.ensembl.org/id/ENSBTAG00000002034" } ] } } ], "crossref": [ { "id": "E1B7T6", "url": "https://alphafold.ebi.ac.uk/entry/E1B7T6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002034", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002034", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039672", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039672", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B7T6", "url": "https://www.orthodb.org/?gene=E1B7T6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11328", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11328", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11328:SF30", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11328:SF30", "database": "PANTHER", "categories": [ "Protein 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"MAVYREAIPGPALETPSTSLEAHTSAQGSDSGAGRLSFYRKLCYGIGGVPNQVASSAIAFYLQLFLLDVAQIPAAQVSLVLFGGKVSGAAADPLAGFLINRSRRTGSGRLMPWVLGCMPFIALAYFFLWFLPPFTTLRGLWYTTLYCLFQALATFFQVPYTALTMLLTPNPKERDSATAYRMTLEMAGTLMGATVHGLIVSGAHGSHRCKEDTLPGEGAVSPNATRLYFIAATVVALTYPVCSTLLYLGVKERSDPSTPASGQGLGFLAGLGLTVRHRPYLNLVISFLFISAAVQVEQSYLVLFCTHASQLQDHVQGMVLTILVSAVLSTPMWEWVLQRFGKRMSALGICAMVPFAILLAAVPMVPVAYVVAFVSGLSIAVSLLLPWSMLPDVVDDFQLQHQHGPGLETIFYSSYVFFTKLSGAGALGISTLSLDFAGYESGACRQSEQVVVTLKVLIGAVPTSMILIGLCILMVGPTPKVPSRANSRSLGRRTSYTLA", "length": 499, "header": "tr|E1B7T6-1|E1B7T6_BOVIN Isoform 1 of Sphingosine-1-phosphate transporter MFSD2B OS=Bos taurus OX=9913 GN=MFSD2B PE=3 SV=3 CANONICAL=E1B7T6-1" }, "isoforms": [ { "isoform_ac": "E1B7T6-1", "url": "https://www.uniprot.org/uniprotkb/E1B7T6/entry#E1B7T6-1", "sequence": { "sequence": 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"https://www.ensembl.org/id/ENSBTAP00000041195.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 258, "start_aa": "Thr", "end_pos": 258, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr258", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 478, "start_aa": "Thr", "end_pos": 478, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr478", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-1660661", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660661", "resource": "Reactome", "description": "Sphingolipid de novo biosynthesis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1B7T6", "url": "https://www.uniprot.org/uniprotkb/E1B7T6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "E1B7T6", "url": "https://www.uniprot.org/uniprotkb/E1B7T6" } ], "pmid": "" }, { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "E1B7T6", "url": "https://www.uniprot.org/uniprotkb/E1B7T6" } ], "pmid": "" }, { "name": "carbohydrate transport", "id": "GO:0008643", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008643", "evidence": [ { "database": "UniProtKB", "id": "E1B7T6", "url": "https://www.uniprot.org/uniprotkb/E1B7T6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "symporter activity", "id": "GO:0015293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015293", "evidence": [ { "database": "UniProtKB", "id": "E1B7T6", "url": "https://www.uniprot.org/uniprotkb/E1B7T6" } ], "pmid": "" }, { "name": "sphingolipid transporter activity", "id": "GO:0046624", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046624", "evidence": [ { "database": "UniProtKB", "id": "E1B7T6", "url": "https://www.uniprot.org/uniprotkb/E1B7T6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 223, "end_pos": 225, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "38667", "name": "", "equation": "sphing-4-enine 1-phosphate(in) = sphing-4-enine 1-phosphate(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "38667", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38667" } ] }, { "id": "38671", "name": "", "equation": "sphinganine 1-phosphate(in) = sphinganine 1-phosphate(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "38671", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38671" } ] }, { "id": "70207", "name": "", "equation": "sphinga-4E,14Z-dienine-1-phosphate(in) = sphinga-4E,14Z-dienine-1-phosphate(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "70207", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70207" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7T6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 499, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7T6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7T6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 258, 478 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 }, { "start_pos": 223, "end_pos": 225 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B7T8-1", "uniprot_ac": "E1B7T8", "uniprot_id": "E1B7T8_BOVIN", "mass": { "chemical_mass": 35025.0, "monoisotopic_mass": 35025.0 }, "refseq": { "ac": "NP_001178259", "name": "glycine N-acyltransferase-like protein 2", "summary": "", "url": 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} ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7T8", "url": "https://www.uniprot.org/uniprotkb/E1B7T8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GLYATL2", "url": "https://www.uniprot.org/uniprotkb/E1B7T8", "locus": { "chromosome": "15", "start_pos": 82180216, "end_pos": 82192695, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030847", "url": "https://www.ensembl.org/id/ENSBTAG00000030847" } ] } } ], "crossref": [ { "id": "E1B7T8", "url": "https://alphafold.ebi.ac.uk/entry/E1B7T8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030847", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030847", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515352", "url": 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"G3MXQ9", "url": "https://www.orthodb.org/?gene=G3MXQ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15298", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15298", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15298:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15298:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06021", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06021", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08444", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08444", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-159424", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159424", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-177128", "url": 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"https://www.uniprot.org/uniprotkb/G3MXQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFVLREPQQLQILYESLEESIPESLKVYGTLFHIRNKNPFNLEVLVDAWPEYQTVVIRPQKEEMKDDLDYYTNTYHIFTKAPDKLEEVLACPQVINWEQAFQIQGCQESLGEAIQKVAASKSVQVDYLRTVLFVFEKPTLEASSGDKMDLMKLLKIPKVLEDKRKETFQNIFLDVSHARLVNEHWELGKNEKSLKYVERCLQNFAGFGVLSSEGKPISWFLTEQSCEIRMGYTFPKYRGQGHMWQMGCHSIAYFFSKKIPFYIHAAEDKEKTQQTLLSFGFKNVLCGWHQWKCTPKKYC", "length": 299, "header": "tr|E1B7T8-1|E1B7T8_BOVIN Isoform 1 of Glycine N-acyltransferase-like protein OS=Bos taurus OX=9913 GN=GLYATL2 PE=3 SV=3 CANONICAL=E1B7T8-1" }, "isoforms": [ { "isoform_ac": "E1B7T8-1", "url": "https://www.uniprot.org/uniprotkb/E1B7T8/entry#E1B7T8-1", "sequence": { "sequence": "MFVLREPQQLQILYESLEESIPESLKVYGTLFHIRNKNPFNLEVLVDAWPEYQTVVIRPQKEEMKDDLDYYTNTYHIFTKAPDKLEEVLACPQVINWEQAFQIQGCQESLGEAIQKVAASKSVQVDYLRTVLFVFEKPTLEASSGDKMDLMKLLKIPKVLEDKRKETFQNIFLDVSHARLVNEHWELGKNEKSLKYVERCLQNFAGFGVLSSEGKPISWFLTEQSCEIRMGYTFPKYRGQGHMWQMGCHSIAYFFSKKIPFYIHAAEDKEKTQQTLLSFGFKNVLCGWHQWKCTPKKYC", "length": 299, "header": "tr|E1B7T8-1|E1B7T8_BOVIN Isoform 1 of Glycine N-acyltransferase-like protein OS=Bos taurus OX=9913 GN=GLYATL2 PE=3 SV=3 CANONICAL=E1B7T8-1" }, "locus": { "chromosome": "15", "start_pos": 82187979, "end_pos": 82181220, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043617.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043617.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041176.5", "url": "https://www.ensembl.org/id/ENSBTAP00000041176.5" } ] } }, { "isoform_ac": "G3MXQ9-1", "url": "https://www.uniprot.org/uniprotkb/E1B7T8/entry#G3MXQ9-1", "sequence": { "sequence": "MFVLREPQQLQILYESLEESIPESLKVYGTLFHIRNKNPFNLEVLVDAWPEYQTVVIRPQKEMKDDLDYYTNTYHIFTKAPDKLEEVLACPQVINWEQAFQIQGCQESLGEAIQKVAASKSVQVDYLRTVLFVFEKPTLEASSGDKMDLMKLLKIPKVLEDKRKETFQNIFLDVSHARLVNEHWELGKNEKSLKYVERCLQNFAGFGVLSSEGKPISWFLTEQSCEIRMGYTFPKYRGQGHMWQMGCHSIAYFFSKKIPFYIHAAEDKEKTQQTLLSFGFKNVLCGWHQWKCTPKKYC", "length": 298, "header": "tr|G3MXQ9-1|E1B7T8_BOVIN Computationally mapped isoform of Glycine N-acyltransferase-like protein OS=Bos taurus OX=9913 GN=GLYATL2 PE=3 SV=2 CANONICAL=E1B7T8-1" }, "locus": { "chromosome": "15", "start_pos": 82187979, "end_pos": 82181220, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063894.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063894.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054327.2", "url": "https://www.ensembl.org/id/ENSBTAP00000054327.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:515352", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515352", "resource": "KEGG Pathway" }, { "id": "R-BTA-159424", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159424", "resource": "Reactome", "description": "Conjugation of carboxylic acids" }, { "id": "R-BTA-177128", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-177128", "resource": "Reactome", "description": "Conjugation of salicylate with glycine" }, { "id": "R-BTA-177135", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-177135", "resource": "Reactome", "description": "Conjugation of benzoate with glycine" }, { "id": "R-BTA-9749641", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9749641", "resource": "Reactome", "description": "Aspirin ADME" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8WU03-1", "protein_name": "Glycine N-acyltransferase-like protein 2", "gene_name": "GLYATL2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLVLHNSQKLQILYKSLEKSIPESIKVYGAIFNIKDKNPFNMEVLVDAWPDYQIVITRPQKQEMKDDQDHYTNTYHIFTKAPDKLEEVLSYSNVISWEQTLQIQGCQEGLDEAIRKVATSKSVQVDYMKTILFIPELPKKHKTSSNDKMELFEVDDDNKEGNFSNMFLDASHAGLVNEHWAFGKNERSLKYIERCLQDFLGFGVLGPEGQLVSWIVMEQSCELRMGYTVPKYRHQGNMLQIGYHLEKYLSQKEIPFYFHVADNNEKSLQALNNLGFKICPCGWHQWKCTPKKYC", "length": 294 }, "evidence": [ { "id": "E1B7T8", "url": "https://omabrowser.org/oma/group/E1B7T8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "monounsaturated fatty acid catabolic process", "id": "GO:1903965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903965", "evidence": [ { "database": "UniProtKB", "id": "E1B7T8", "url": "https://www.uniprot.org/uniprotkb/E1B7T8" } ], "pmid": "" }, { "name": "long-chain fatty acid catabolic process", "id": "GO:0042758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042758", "evidence": [ { "database": "UniProtKB", "id": "E1B7T8", "url": "https://www.uniprot.org/uniprotkb/E1B7T8" } ], "pmid": "" }, { "name": "medium-chain fatty acid catabolic process", "id": "GO:0051793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051793", "evidence": [ { "database": "UniProtKB", "id": "E1B7T8", "url": "https://www.uniprot.org/uniprotkb/E1B7T8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1B7T8", "url": "https://www.uniprot.org/uniprotkb/E1B7T8" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "E1B7T8", "url": "https://www.uniprot.org/uniprotkb/E1B7T8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "N-acyltransferase activity", "id": "GO:0016410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016410", "evidence": [ { "database": "UniProtKB", "id": "E1B7T8", "url": "https://www.uniprot.org/uniprotkb/E1B7T8" } ], "pmid": "" }, { "name": "glycine N-acyltransferase activity", "id": "GO:0047961", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047961", "evidence": [ { "database": "UniProtKB", "id": "E1B7T8", "url": "https://www.uniprot.org/uniprotkb/E1B7T8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-159566", "name": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [ "R-ALL-159564" ], "enzyme_list": [ "E1BI09-1", "A0A3Q1MPE2-1", "E1B7T8-1" ], "evidence": [ { "id": "R-BTA-159566", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159566" } ] }, { "id": "R-BTA-159574", "name": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [ "R-ALL-159572" ], "enzyme_list": [ "E1BI09-1", "A0A3Q1MPE2-1", "E1B7T8-1" ], "evidence": [ { "id": "R-BTA-159574", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159574" } ] }, { "id": "R-BTA-9750001", "name": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-9749985" ], "output_participant_list": [ "R-ALL-9750005" ], "enzyme_list": [ "E1BI09-1", "A0A3Q1MPE2-1", "E1B7T8-1" ], "evidence": [ { "id": "R-BTA-9750001", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9750001" } ] }, { "id": "R-BTA-9971063", "name": "GLYAT-like proteins transfer glycine to phenylacetyl-CoA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-177137" ], "output_participant_list": [ "R-ALL-9971077" ], "enzyme_list": [ "E1BI09-1", "A0A3Q1MPE2-1", "E1B7T8-1" ], "evidence": [ { "id": "R-BTA-9971063", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9971063" } ] }, { "id": "R-BTA-9972916", "name": "GLYAT-like proteins transfer glycine to aminobenzoyl-CoA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-9972915" ], "output_participant_list": [ "R-ALL-9972914" ], "enzyme_list": [ "E1BI09-1", "A0A3Q1MPE2-1", "E1B7T8-1" ], "evidence": [ { "id": "R-BTA-9972916", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9972916" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-159564", "participant_name": "HIPA [mitochondrial matrix]", "crossref": [ { "id": "C01586", "database": "COMPOUND", "url": "" }, { "id": "606565", "database": "ChEBI", "url": "" }, { "id": "ZINC000006344064", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-159572", "participant_name": "SUA [mitochondrial matrix]", "crossref": [ { "id": "8145924", "database": "PubChem Substance", "url": "" }, { "id": "ZINC000000125017", "database": "ZINC", "url": "" }, { "id": "9008", "database": "ChEBI", "url": "" }, { "id": "C07588", "database": "COMPOUND", "url": "" }, { "id": "HMDB0000840", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-177137", "participant_name": "phenylacetyl-CoA [mitochondrial matrix]", "crossref": [ { "id": "57390", "database": "ChEBI", "url": "" }, { "id": "ZINC000096014556", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-9749985", "participant_name": "2,5-DHB-CoA [mitochondrial matrix]", "crossref": [ { "id": "90176", "database": "ChEBI", "url": "" }, { "id": "ZINC000198019174", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-9750005", "participant_name": "gentisuric acid [mitochondrial matrix]", "crossref": [ { "id": "88742", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-9971077", "participant_name": "phenylacetyl-Gly [mitochondrial matrix]", "crossref": [ { "id": "60874", "database": "ChEBI", "url": "" }, { "id": "ZINC000000136391", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-9972914", "participant_name": "PAH [cytosol]", "crossref": [ { "id": "ZINC000000119344", "database": "ZINC", "url": "" }, { "id": "64703", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-9972915", "participant_name": "PABA-CoA [cytosol]", "crossref": [ { "id": "188497", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MPE2", "gene_name": "GLYAT", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "A0A3Q1MPE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPE2" } ] } ] }, { "uniprot_ac": "E1B7T8", "gene_name": "GLYATL2", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "E1B7T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7T8" } ] } ] }, { "uniprot_ac": "E1BI09", "gene_name": "GLYATL3", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "E1BI09", "database": "UniProtKB", "url": 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"field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B7U5-1", "uniprot_ac": "E1B7U5", "uniprot_id": "E1B7U5_BOVIN", "mass": { "chemical_mass": 35152.0, "monoisotopic_mass": 35152.0 }, "refseq": { "ac": "NP_001376932", "name": "olfactory receptor family 52 subfamily B member 3", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376932" }, "gene_names": [ { "name": "OR52B3", "type": "recommended", "evidence": [ { "id": "E1B7U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7U5" } ] }, { "name": "OR52B3", "type": "synonym", "evidence": [ { "id": "NP_001376932", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376932" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "E1B7U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7U5/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 52B4", "type": "synonym", "evidence": [ { "id": "NP_001376932", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376932" } ] }, { "name": "olfactory receptor family 52 subfamily B member 3", "type": "synonym", "evidence": [ { "id": "NP_001376932", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376932" } ] } ], "function": [ { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1B7U5", "url": "https://www.uniprot.org/uniprotkb/E1B7U5#function" }, { "database": "UniProtKB", "id": "ARBA00002936", "url": "https://www.uniprot.org/uniprotkb/ARBA00002936#function" } ] }, { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376932" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1B7U5", "url": "https://www.uniprot.org/uniprotkb/E1B7U5#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7U5", "url": "https://www.uniprot.org/uniprotkb/E1B7U5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR52B3", "url": "https://www.uniprot.org/uniprotkb/E1B7U5", "locus": { "chromosome": "15", "start_pos": 50655747, "end_pos": 50656697, "strand": "+", "evidence": 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"IPR050402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518464", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518464", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450:SF97", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450:SF97", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376932", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1B7U5", "url": "https://www.uniprot.org/uniprotkb/E1B7U5", 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"total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "E1B7Z0-1", "uniprot_ac": "E1B7Z0", "uniprot_id": "E1B7Z0_BOVIN", "mass": { "chemical_mass": 76328.0, "monoisotopic_mass": 76328.0 }, "refseq": { "ac": "NP_001179301", "name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179301" }, "gene_names": [ { "name": "TAB2", "type": "recommended", "evidence": [ { "id": "E1B7Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0" } ] }, { "name": "MAP3K7IP2", "type": "synonym", "evidence": [ { "id": "NP_001179301", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179301" } ] }, { "name": "TAB2", "type": "synonym", "evidence": [ { "id": "NP_001179301", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179301" } ] } ], "protein_names": [ { "name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "type": "recommended", "evidence": [ { "id": "E1B7Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0/entry#names_and_taxonomy" } ] }, { "name": "Mitogen-activated protein kinase kinase kinase 7-interacting protein 2", "type": "synonym", "evidence": [ { "id": "E1B7Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0/entry#names_and_taxonomy" } ] }, { "name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "type": "synonym", "evidence": [ { "id": "NP_001179301", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179301" } ] }, { "name": "TGF-beta-activated kinase 1-binding protein 2", "type": "synonym", "evidence": [ { "id": "E1B7Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0/entry#names_and_taxonomy" } ] }, { "name": "mitogen-activated protein kinase kinase kinase 7 interacting protein 2", "type": "synonym", "evidence": [ { "id": "NP_001179301", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179301" } ] } ], "function": [ { "annotation": "Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains. Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development.", "evidence": [ { "database": "UniProtKB", "id": "E1B7Z0", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0#function" }, { "database": "UniProtKB", "id": "ARBA00058038", "url": "https://www.uniprot.org/uniprotkb/ARBA00058038#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1B7Z0", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAB2", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0", "locus": { "chromosome": "9", "start_pos": 86652158, "end_pos": 86612590, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013454", "url": "https://www.ensembl.org/id/ENSBTAG00000013454" } ] } } ], "crossref": [ { "id": "E1B7Z0", "url": "https://alphafold.ebi.ac.uk/entry/E1B7Z0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013454", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013454", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14362", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14362", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540203", "url": "https://www.ncbi.nlm.nih.gov/gene/540203", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001876", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001876", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036443", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036443", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041911", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041911", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540203", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540203", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GPTFIHH", "url": "https://omabrowser.org/oma/group/GPTFIHH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B7Z0", "url": "https://www.orthodb.org/?gene=E1B7Z0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46253", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46253", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46253:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46253:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02845", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02845", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-168638", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-168638", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-202424", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202424", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2871837", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2871837", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-445989", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-445989", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-450302", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450302", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-450321", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450321", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": 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"MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDDSGISGLRNHMTSLNLDLQSQNVYHHGREGNRMNGSRTLTHSISDGQLQGGQSNNELFQQEPQTAPAQVPQGFNVFGMSSASGASNSAPHLGFHLGSKGTSNLSPQTPRFNPIMVTLAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPSGTTRQTQQHSGWVSQFNPMNPQQVYQPSQPGPWTTYPASSPLPHTSAQQPNQQGHQTSHVYMPISSPTTPQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSSSSSVNSQTLNRNQPTVYIAASPPNTDEVMSRSQPKVYISANAAAGDEQVIRNQPTLFISTNSGASAASRNMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPALAHVDRISDARKLSMGSDDAAYTQALLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSTIKTPKTQDTEDDEGAQWSCAACTFLNHPALIRCEQCEMPRHL", "length": 693, "header": "tr|E1B7Z0-1|E1B7Z0_BOVIN Isoform 1 of TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 OS=Bos taurus OX=9913 GN=TAB2 PE=4 SV=1 CANONICAL=E1B7Z0-1" }, "isoforms": [ { "isoform_ac": "E1B7Z0-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0/entry#E1B7Z0-1", "sequence": { "sequence": "MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDDSGISGLRNHMTSLNLDLQSQNVYHHGREGNRMNGSRTLTHSISDGQLQGGQSNNELFQQEPQTAPAQVPQGFNVFGMSSASGASNSAPHLGFHLGSKGTSNLSPQTPRFNPIMVTLAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPSGTTRQTQQHSGWVSQFNPMNPQQVYQPSQPGPWTTYPASSPLPHTSAQQPNQQGHQTSHVYMPISSPTTPQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSSSSSVNSQTLNRNQPTVYIAASPPNTDEVMSRSQPKVYISANAAAGDEQVIRNQPTLFISTNSGASAASRNMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPALAHVDRISDARKLSMGSDDAAYTQALLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSTIKTPKTQDTEDDEGAQWSCAACTFLNHPALIRCEQCEMPRHL", "length": 693, "header": "tr|E1B7Z0-1|E1B7Z0_BOVIN Isoform 1 of TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 OS=Bos taurus OX=9913 GN=TAB2 PE=4 SV=1 CANONICAL=E1B7Z0-1" }, "locus": { "chromosome": "9", "start_pos": 86651697, "end_pos": 86612680, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017897.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017897.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017897.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017897.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540203", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540203", "resource": "KEGG Pathway" }, { "id": "R-BTA-168638", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-168638", "resource": "Reactome", "description": "NOD1/2 Signaling Pathway" }, { "id": "R-BTA-202424", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202424", "resource": "Reactome", "description": "Downstream TCR signaling" }, { "id": "R-BTA-2871837", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2871837", "resource": "Reactome", "description": "FCERI mediated NF-kB activation" }, { "id": "R-BTA-445989", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-445989", "resource": "Reactome", "description": "TAK1-dependent IKK and NF-kappa-B activation" }, { "id": "R-BTA-450302", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450302", "resource": "Reactome", "description": "activated TAK1 mediates p38 MAPK activation" }, { "id": "R-BTA-450321", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450321", "resource": "Reactome", "description": "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" }, { "id": "R-BTA-5357956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5357956", "resource": "Reactome", "description": "TNFR1-induced NF-kappa-B signaling pathway" }, { "id": "R-BTA-5607764", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5607764", "resource": "Reactome", "description": "CLEC7A (Dectin-1) signaling" }, { "id": "R-BTA-9020702", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9020702", "resource": "Reactome", "description": "Interleukin-1 signaling" }, { "id": "R-BTA-937042", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-937042", "resource": "Reactome", "description": "IRAK2 mediated activation of TAK1 complex" }, { "id": "R-BTA-937072", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-937072", "resource": "Reactome", "description": "TRAF6-mediated induction of TAK1 complex within TLR4 complex" }, { "id": "R-BTA-9645460", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9645460", "resource": "Reactome", "description": "Alpha-protein kinase 1 signaling pathway" }, { "id": "R-BTA-975163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975163", "resource": "Reactome", "description": "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XYF8-1", "protein_name": "TGF-beta activated kinase 1 (MAP3K7) binding protein 2", "gene_name": "TAB2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MCPRFPLEFSNLLVDITEILELIGCGLKKKQKLSKENAFKLNNNNNLDACCAVLSQESTKYLYGEGDLSFSDDSAIPGLRNHMTSLNLDLQSQNVYHHGRDGRMNGSRTLAHSVSDGHLQTKQPNNELFQQEPQTAPAQVPQGFNVFGMGNTVSASNPGQHLGFHLGSKGVSNLSQQTPRFNPIMVTLAPNIQPGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITAPSGTARQTQQQAGWASQFNPMHPQQVYQPSQPSPWTTLPTSNTTPHTSSQHSTQPNQQGHQTSHVYMPISSPTTPQAPMIHSSGSAQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNSSSKLRSTGPRTSTTPSSLNSQTLSRSQPTVYISASPPNTDEVITRGQPKVYISANATTGDDQLVRNQPTLFISTNPGVSATSRNMSGQVSMGPAFIHHHPPKSRAVGNSTTATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFEPTNLLNLPDHYVEPEGIQHLTDPVLAHVDRISDARKLSMGSDDAAYTQALLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSVSQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFLGPVPPKPKDQRSIVKTPKTVPDADEDEGAQWSCTACTFLNHPALNRCEQCEMPRHF", "length": 705 }, "evidence": [ { "id": "E1B7Z0", "url": "https://omabrowser.org/oma/group/E1B7Z0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S7S1-1", "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "gene_name": "TAB2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDDSGISGLRNHMTSLNLDLQSQNVYHHGREGNRMNGSRTLTHSISDGQLQGGQSNNELFQQEPQTAPAQVPQGFNVFGMSSTSGASNSAPHLGFHLGSKGTSNLSQQTPRFNPIMVTLAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPSGTARQTQQHSGWVSQFNPMNPQQVYQPSQPGPWTTYPASNPLPHTSAQQPNQQGHQTSHVYMPISSPTTPQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNSSSKLRSSGPRTSSSSSVNSQTLNRNQPTVYIAASPPNTDEVMSRSQPKVYISANATTGDEQVIRNQPTLFISTNSGASAAARNMSGQVSMGPAFIHHHPPKSRAIGSNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISEARKLSMGSDDAAYTQALLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSSIKTPKSQDTEDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF", "length": 692 }, "evidence": [ { "id": "E1B7Z0", "url": "https://omabrowser.org/oma/group/E1B7Z0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5RFW2-1", "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "gene_name": "tab2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAQGNQQIDNQVLHHLRQKFPEVPEDVVCECVLQNKSDLAACCEYLTKVSPRFLYSEGSQSLTDLRNHMTQLNLGVSQNTHGAVQRDAVGMNGSRTLAPSVSDGPLNVPSALSEFYQPETPSVPTHTPASLSMESTRKPQPPQHLGLYQVGGKGHAPPQAPRFNPITVTLAPNTGRNTPTSLHIHGGPQSGLNSPNSIYIRPYVTQPGSTRQVQCRAQYSPTSQPAQQIYQITHPAAPQSSWSQHQTSHVYMPISSPTNTQAPSIPSAVASQAVSSSPLPSSGSSFSQYNIQNISTGPRKNQIEIKLESPQRGSGSSSLLRSSSAPRSACSSTSSSCPSSCTSLASSSGSSTPISIGGAGLSRSQPTVYISPSPPTAATAPSEDCALVPNTPRSQPKIYFSANTSADDGGGRNPPTVYISANPALQGPAGLRALGSQMSMGPAYIHHHPPKSRPSVGAGGTATSPRVVVTQPNTKYTFKITVSPNKPPSVSPGVVSPTFEPNNMLSLPADHHYAEPEISQPDPMRDKAVEPRRLSMGADDAAYTQALLVHQRARMERLWHELELKKRKLEKLKEEVNEMESDLTRRRLQRSNAFCQIPSIEEMQQLRCKNRLLQIDIDCLTKEIDLLQTRGPDFNPIAIHNFYDNLGFLGPVPPKPLKGPTKAEVSRTDAGVRVLSEPEEDDGVQWSCTACTFLNHPALNRCEECEFPRNF", "length": 711 }, "evidence": [ { "id": "E1B7Z0", "url": "https://omabrowser.org/oma/group/E1B7Z0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5U303-1", "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "gene_name": "Tab2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDESGISGLRNHMTSLNLDLQSQNVYHHGREGSRVNGSRTLTHSVSDGQLQGGQSNNELFQQEPQTAPAQVPQGFNVFGMPSTSGASNSTPHLGFHLGSKGTSNLSQQTPRFNPIMVTLAPNIQTGRSTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPSGAARQTQQHSGWVSQFNPVNPQQAYQPSQPGPWTTYPASNPLPHTSTQQPNQQGHQTSHVYMPISSPTTPQPPTVHSSASSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNSSSKLRSSGPRTASTSSLVNSQTLNRNQPTVYIAASPPSTDEMISRSQPKVYISANASTGDEQGMRNQPTLFISTNSGASAASRNMSGQVSMGPAFIHHHPPKSRVLGGNSAASPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETETIQHLTDPTLAHVDRVSEARKLSMGSDDAAYTQALLVHQKARMERLQRELEMQKKKLDKLKSEVNEMENSLTRRRLKRSNSMSQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSTIKAPKTQDTEDEEGAQWNCTACTFLNHPALIRCEQCEMPRHF", "length": 693 }, "evidence": [ { "id": "E1B7Z0", "url": "https://omabrowser.org/oma/group/E1B7Z0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99K90-1", "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "gene_name": "Tab2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDESGISGLRNHMTSLNLDLQSQNVYHHGREGSRVNGSRTLTHSVSDGQLHGGQSNNELFQQEPQTAPAQVPQGFNVFGMPSTSGASNSTPHLGFHLGSKGTSNLSQQTPRFNPIMVTLAPNIQTGRSTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPSGTARQTQQHSGWVSQFNPMNPQQAYQPSQPGPWTTYPASNPLPHTSTQQPNQQGHQTSHVYMPISSPTTPQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNSSSKLRSSGPRTASTSSLVNSQTLNRNQPTVYIAASPPNTDEMISRSQPKVYISANATAGDEQGMRNQPTLFISTNSGPSAASRNMSGQVSMGPAFIHHHPPKSRVLGGNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPALAHVDRISEARKLSMGSDDAAYTQALLVHQKARMERLQRELEMQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSTIKAPKTQDAEDEEGAQWNCTACTFLNHPALIRCEQCEMPRHF", "length": 693 }, "evidence": [ { "id": "E1B7Z0", "url": "https://omabrowser.org/oma/group/E1B7Z0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NYJ8-1", "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2", "gene_name": "TAB2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSELFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVTLAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFNPMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTLNRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASRNMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDTEDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF", "length": 693 }, "evidence": [ { "id": "E1B7Z0", "url": "https://omabrowser.org/oma/group/E1B7Z0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "E1B7Z0", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1B7Z0", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0" } ], "pmid": "" }, { "name": "ubiquitin binding", "id": "GO:0043130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130", "evidence": [ { "database": "UniProtKB", "id": "E1B7Z0", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0" } ], "pmid": "" }, { "name": "K63-linked polyubiquitin modification-dependent protein binding", "id": "GO:0070530", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070530", "evidence": [ { "database": "UniProtKB", "id": "E1B7Z0", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1B7Z0", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1B7Z0", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "E1B7Z0", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "E1B7Z0", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "E1B7Z0", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "E1B7Z0", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0" } ], "pmid": "" }, { "name": "response to lipopolysaccharide", "id": "GO:0032496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032496", "evidence": [ { "database": "UniProtKB", "id": "E1B7Z0", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0" } ], "pmid": "" }, { "name": "positive regulation of canonical NF-kappaB signal transduction", "id": "GO:0043123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "database": "UniProtKB", "id": "E1B7Z0", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0" } ], "pmid": "" }, { "name": "defense response to bacterium", "id": "GO:0042742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", "evidence": [ { "database": "UniProtKB", "id": "E1B7Z0", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0" } ], "pmid": "" }, { "name": "canonical NF-kappaB signal transduction", "id": "GO:0007249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007249", "evidence": [ { "database": "UniProtKB", "id": "E1B7Z0", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0" } ], "pmid": "" }, { "name": "non-canonical NF-kappaB signal transduction", "id": "GO:0038061", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038061", "evidence": [ { "database": "UniProtKB", "id": "E1B7Z0", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0" } ], "pmid": "" }, { "name": "regulation of MAPK cascade", "id": "GO:0043408", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043408", "evidence": [ { "database": "UniProtKB", "id": "E1B7Z0", "url": "https://www.uniprot.org/uniprotkb/E1B7Z0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 316, "end_pos": 318, "annotation": "n_glycosylation_sequon" }, { "start_pos": 336, "end_pos": 338, "annotation": "n_glycosylation_sequon" }, { "start_pos": 337, "end_pos": 339, "annotation": "n_glycosylation_sequon" }, { "start_pos": 421, "end_pos": 423, "annotation": "n_glycosylation_sequon" }, { "start_pos": 445, "end_pos": 447, "annotation": "n_glycosylation_sequon" }, { "start_pos": 571, "end_pos": 573, "annotation": "n_glycosylation_sequon" }, { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" }, { "start_pos": 98, "end_pos": 100, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1B7Z0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 693, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1B7Z0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1B7Z0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 166, "end_pos": 168 }, { "start_pos": 316, "end_pos": 318 }, { "start_pos": 336, "end_pos": 338 }, { "start_pos": 337, "end_pos": 339 }, { "start_pos": 421, "end_pos": 423 }, { "start_pos": 445, "end_pos": 447 }, { "start_pos": 571, "end_pos": 573 }, { "start_pos": 61, "end_pos": 63 }, { "start_pos": 98, "end_pos": 100 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] } ]